title: Neurological manifestations of primary Sjögren's syndrome in Japanese patients.
abstract: The neurological manifestations of twenty-one Japanese patients with Sjögren's syndrome (SjS) were evaluated. All patients were women, and sixteen of the twenty-one cases (76%) demonstrated objective abnormal neurological symptoms, the most frequently observed of which was trigeminal neuropathy (50%). Multiple mononeuropathy was seen in almost one-third of the examined cases (31%). Central nervous system (CNS) involvement was observed in three cases (14%). All of these values differed greatly from those previously reported. Therefore, this study revealed characteristic features of Japanese SjS and also implied the existence of different immunopathological mechanisms associated with SjS in Japanese patients.
authors.affiliation: Department of Neurology, Hokkaido University School of Medicine, Sapporo.
authors.forename: Y
authors.initials: Y
authors.lastname: Tajima
authors.forename: Y
authors.initials: Y
authors.lastname: Mito
authors.forename: Y
authors.initials: Y
authors.lastname: Owada
authors.forename: E
authors.initials: E
authors.lastname: Tsukishima
authors.forename: F
authors.initials: F
authors.lastname: Moriwaka
authors.forename: K
authors.initials: K
authors.lastname: Tashiro
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D007564:Japan; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis; D013116:Spinal Cord / Q000473:pathology; D013497:Sural Nerve / Q000648:ultrastructure; D014277:Trigeminal Neuralgia / Q000175:diagnosis / Q000209:etiology