Are serum progesterone levels predictive of recurrent miscarriage in future pregnancies?
OBJECTIVE
To examine the predictive value of midluteal serum P as a marker of a luteal phase defect (LPD) in future pregnancies of recurrent aborters.


METHODS
Prospective analysis.


METHODS
Nagoya City University Hospital.


METHODS
One hundred ninety-seven women with a history of two consecutive first trimester abortions, none of whom had any other medical problems or an identifiable cause of recurrent miscarriages, such as uterine anomalies or evidence of antiphospholipid antibodies. None of the study subjects received any medication for miscarriage or infertility.


METHODS
A midluteal phase single serum P level < 10 ng/mL was used as the criterion for a potential LPD: those whose subsequent pregnancy was successful and those in which failure was the end result.


RESULTS
Of the 197 patients, 46 (23.4%) demonstrated LPD without other endocrine abnormalities and 38 (19.3%) recurrent aborters suffered another abortion, with figures for LPD-negative and LPD-positive patients of 20.5% (31/151) and 15.2% (7/46), respectively. There was no statistically significant difference between the two groups.


CONCLUSIONS
Progesterone, E2, and the P/E2 ratio may not predict future pregnancy loss in recurrent aborters.
Ogasawara
M
M
Department of Obstetrics and Gynecology, Nagoya City University Medical School, Japan.
Kajiura
S
S
Katano
K
K
Aoyama
T
T
Aoki
K
K
D000026:Abortion, Habitual / Q000097:blood / Q000175:diagnosis*; D000328:Adult; D002869:Chromosome Aberrations; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000097:blood*; D011446:Prospective Studies; D012016:Reference Values
D011374:Progesterone; D004958:Estradiol