title: Methotrexate use in psoriasis and psoriatic arthritis.
abstract: Methotrexate is an extremely effective drug in the treatment of psoriasis and psoriatic arthritis. In addition, it possesses a very high benefit-to-toxicity ratio compared with other therapies and immunosuppressive agents used in these disorders. Fortunately, most adverse events related to methotrexate are mild, but serious and life-threatening reactions, particularly liver toxicity, may occur. Careful monitoring is essential to prevent most undesirable side effects.
authors.affiliation: Department of Medicine, Louisiana State University School of Medicine at New Orleans, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Cuellar
authors.forename: L R
authors.initials: LR
authors.lastname: Espinoza
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D016903:Drug Monitoring; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000473:pathology; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate