title: Prior brain injury protects death from local anaesthetic-induced convulsion.
abstract: Minor brain injury was inflicted with a small hypodermic needle at four sites from the scalp 7 days before the production of convulsion by i.p. injection of 100 mg/kg lidocaine in mice. The latency to convulsion and survival rate were significantly longer and higher, respectively, in the brain-injured group than in the sham-operated one. Thus, the results suggest that a protective mechanism develops in the injured brain against asphyxia caused by lidocaine convulsion.
authors.affiliation: Department of Anaesthesia, Niigata City Hospital, Niigata, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Endoh
authors.forename: Y
authors.initials: Y
authors.lastname: Kumagai
authors.forename: H
authors.initials: H
authors.lastname: Baba
authors.forename: T
authors.initials: T
authors.lastname: Yamakura
authors.forename: K
authors.initials: K
authors.lastname: Taga
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Fukuda
authors.forename: K
authors.initials: K
authors.lastname: Shimoji
mesh_terms: D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D001930:Brain Injuries / Q000150:complications*; D008012:Lidocaine / Q000633:toxicity*; D008297:Male; D051379:Mice; D011930:Reaction Time / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000401:mortality*; D015996:Survival Rate
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine