The design, synthesis and transmembrane transport studies of a biomimetic sterol-based ion channel.
A model sterol-based ion channel was rationally designed and synthesized. The potential ion channel is comprised of a tartrate-derived crown ether to which six steroids are appended. Macromolecule 1a was incorporated into phospholipid vesicles and shown to facilitate the transmembrane transport of sodium and lithium ions using alkali metal NMR spectroscopy.
Pechulis
A D
AD
Department of Chemistry, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Thompson
R J
RJ
Fojtik
J P
JP
Schwartz
H M
HM
Lisek
C A
CA
Frye
L L
LL
D004988:Ethers, Cyclic / Q000737:chemistry; D007473:Ion Channels / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines / Q000737:chemistry; D013261:Sterols / Q000737:chemistry*; D013644:Tartrates / Q000737:chemistry
D004988:Ethers, Cyclic; D007473:Ion Channels; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D013261:Sterols; D013644:Tartrates; C029768:tartaric acid