Application of capillary electrophoresis in clinical chemistry--developments from preliminary trials to routine analysis.
Since instruments performing capillary electrophoresis (CE) became commercially available in the late 1980s, information on this relatively new analytical technique has been increasing almost exponentially. At the beginning of the last decade, fundamental discoveries in the field were made mainly in the laboratories of analytical chemists; but now, this separation science is giving increasing impact to the laboratories of clinical chemists. This paper briefly reviews the history, instrumentation, different modes and theory of CE, and the prominent fields of its applications in clinical chemistry.
Lehmann
R
R
Medizinische Klinik und Poliklinik, Universität Tübingen, Innere Medizin Abt. IV. Endokrinologie, Pathobiochemie und Klimische Chemie, Germany.
Liebich
H M
HM
Voelter
W
W
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis; D002624:Chemistry, Clinical / Q000295:instrumentation / Q000379:methods*; D003955:Diagnostic Tests, Routine / Q000295:instrumentation / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D006728:Hormones / Q000032:analysis; D006801:Humans; D009479:Neuropeptides / Q000032:analysis; D010455:Peptides / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis; D011506:Proteins / Q000032:analysis; D014815:Vitamins / Q000032:analysis
D000596:Amino Acids; D001679:Biogenic Amines; D006728:Hormones; D009479:Neuropeptides; D010455:Peptides; D004364:Pharmaceutical Preparations; D011506:Proteins; D014815:Vitamins