title: Mantle cell lymphomas: characteristics, natural history and prognostic factors of 45 cases.
abstract: We reviewed 77 cases considered as lymphocytic lymphomas of intermediate differentiation or diffuse centrocytic lymphomas. Forty-five cases were diagnosed as mantle cell lymphoma (MCL). The architectural pattern was diffuse in 95%, 8 cases presented large blastoid cells and CD5 positivity was observed in 28/34 cases. Of 20 cases studied, 8 presented a t(11;14)(q13;q32). Patient characteristics were: median age 59 years, B symptoms in 38%, 87% stages III-IV, bone marrow involvement in 67% with peripheral leukemic cells in 24%. Forty-four patients were treated with chemotherapy and 7 received radiotherapy. The complete response (CR) rate was 58%. Of the 26 CR, 19 relapsed at a median of 15 months. Disease-free survival was 42% and overall survival was 73% at 3 years. In a univariate analysis, overall survival was related to liver and bone marrow involvement, the presence of peripheral lymphomatous cells and achieving a complete response.
authors.affiliation: Department of Medicine, Institute Gustave Roussy, Villejuif, France.
authors.forename: D
authors.initials: D
authors.lastname: Decaudin
authors.forename: J
authors.initials: J
authors.lastname: Bosq
authors.forename: J N
authors.initials: JN
authors.lastname: Munck
authors.forename: C
authors.initials: C
authors.lastname: Bayle
authors.forename: S
authors.initials: S
authors.lastname: Koscielny
authors.forename: S
authors.initials: S
authors.lastname: Boudjemaa
authors.forename: A
authors.initials: A
authors.lastname: Bennaceur
authors.forename: A M
authors.initials: AM
authors.lastname: Venuat
authors.forename: P
authors.initials: P
authors.lastname: Naccache
authors.forename: B
authors.initials: B
authors.lastname: Bendahmane
authors.forename: V
authors.initials: V
authors.lastname: Ribrag
authors.forename: P
authors.initials: P
authors.lastname: Carde
authors.forename: J L
authors.initials: JL
authors.lastname: Pico
authors.forename: M
authors.initials: M
authors.lastname: Hayat
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis