[Regulation of epinephrine on melatonin receptor of the young mouse thymus].
The melatonin binding sites in membrane preparations of the young mouse thymus were studies using [125I] iodomelatonin as the radioligand. Effect of epinephrine (E) on melatonin receptor (MR) of young mouse thymus were investigated.


RESULTS
(1) E had inhibitory effect on MR of mouse thymus; (2) Propranolol could reverse the inhibitory effect of E but phentolamin could not; (3) cAMP had inhibitory effect on MR. These results indicate that E has the inhibitory effect on MR of the mouse thymus and the effect was mediated by beta-adrenergic receptor.
Zhao
Y
Y
Department of Neurology, Chang Zheng Hospital, Second Military Medical University, Shanghai.
Liu
Z M
ZM
Pang
S F
SF
D000818:Animals; D000831:Animals, Newborn; D000242:Cyclic AMP / Q000494:pharmacology; D004837:Epinephrine / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D044094:Receptors, Melatonin; D013950:Thymus Gland / Q000378:metabolism*
D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin; D011433:Propranolol; D000242:Cyclic AMP; D004837:Epinephrine; D010646:Phentolamine