The CD40 pathway in allograft rejection, acceptance, and tolerance.
The CD40 pathway plays a critical role at many levels of the sensitization and effector phases of allograft rejection. In addition to the important signaling role of this pathway for T cell help and effector function, recent evidence suggests that the CD40 pathway can directly co-stimulate T cells, independently of its effect on the B7-CD28 pathway.
Larsen
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CP
Emory University, Atlanta, GA 30322, USA. clarsen@emory.org
Pearson
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TC
D019013:CD40 Antigens; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007108:Immune Tolerance; D016377:Organ Transplantation; D015398:Signal Transduction; D014184:Transplantation, Homologous
D019013:CD40 Antigens