Muscle determination: another key player in myogenesis?
The steps that commit multipotential somite cells to muscle differentiation are being elucidated. Recent results show that pax3 is an upstream regulator of myoD, one of the key genes in myogenic lineage determination.
Borycki
A G
AG
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia 19104-6058, USA.
Emerson
C P
CP
D000818:Animals; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D009124:Muscle Proteins / Q000235:genetics; D009132:Muscles / Q000196:embryology*; D017570:MyoD Protein / Q000502:physiology*; D051787:Myogenic Regulatory Factor 5; D000072041:PAX3 Transcription Factor; D051761:Paired Box Transcription Factors; D015534:Trans-Activators; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D009124:Muscle Proteins; D017570:MyoD Protein; D051787:Myogenic Regulatory Factor 5; D000072041:PAX3 Transcription Factor; D051761:Paired Box Transcription Factors; D015534:Trans-Activators; D014157:Transcription Factors; C068686:Pax3 protein, mouse