Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein.
The nonstructural protein (NS1 protein) of the influenza A virus binds to several types of RNAs. X-ray crystallographic analysis of the RNA-binding domain reveals a unique topology for the monomer as well as a novel six-helix structure for the dimer.
Liu
J
J
Lynch
P A
PA
Chien
C Y
CY
Montelione
G T
GT
Krug
R M
RM
Berman
H M
HM
D000595:Amino Acid Sequence; D001665:Binding Sites; D018360:Crystallography, X-Ray; D019281:Dimerization; D009980:Influenza A virus / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D012313:RNA / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000378:metabolism
C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins; D012313:RNA