Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism.
Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyrus in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.
Gould
E
E
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA. goulde@princeton.edu
Tanapat
P
P
Cameron
H A
HA
D000818:Animals; D000831:Animals, Newborn; D016923:Cell Death / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003345:Corticosterone / Q000494:pharmacology*; D018891:Dentate Gyrus / Q000166:cytology* / Q000187:drug effects / Q000254:growth & development; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D005260:Female; D008297:Male; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D012016:Reference Values
D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D003345:Corticosterone