Carquinostatin B, a new neuronal cell-protecting substance produced by Streptomyces exfoliatus.
Brain ischemia injury is elicited by the excitotoxicity of L-glutamate. Carquinostatin B was isolated from Streptomyces exfoliatus 2419-SVT2 as a potent neuroprotective substance which protests neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity. The structure of carquinostatin B was established principally by NMR studies to be a carbazole derivative with an ortho quinone function.
Shin-ya
K
K
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Kunigami
T
T
Kim
J S
JS
Furihata
K
K
Hayakawa
Y
Y
Seto
H
H
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002477:Cells / Q000187:drug effects; D018698:Glutamic Acid / Q000633:toxicity; D006825:Hybridomas / Q000166:cytology; D009682:Magnetic Resonance Spectroscopy; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
D000975:Antioxidants; D002227:Carbazoles; D018696:Neuroprotective Agents; C111279:carquinostatin B; C041514:carbazole; D018698:Glutamic Acid