title: Ontogenic and nutritional changes in circulating insulin-like growth factor (IGF)-I, IGF-II and IGF-binding proteins in growing ewe and ram lambs.
abstract: The ontogeny of the IGF endocrine system was investigated in 15 young lambs before and after weaning at 62 days of age. Before weaning, plasma IGF-I concentrations were higher in rams than ewes, and plasma concentrations of IGF-II and IGF-binding protein-3 (IGFBP-3) also tended to be higher in rams than in ewes. Feed intake of ewes and rams was restricted after weaning to remove sex differences in feed intake. Plasma concentrations of IGF-I and IGFBP-3 did not differ between rams and ewes at 100 days of age, but plasma IGF-II was higher in rams than in ewes at this time. Since circulating concentrations of GH were higher in rams than in ewes at 100 days of age, this implies that the restricted feed intake blocked the IGF-I and IGFBP-3 responses to GH. We conclude that sex differences in circulating IGF-I and IGFBP-3 concentrations in the growing lamb alter with age, and are not present when nutrition is restricted.
authors.affiliation: Department of Agriculture and Resource Management, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: K L
authors.initials: KL
authors.lastname: Gatford
authors.forename: K J
authors.initials: KJ
authors.lastname: Quinn
authors.forename: P E
authors.initials: PE
authors.lastname: Walton
authors.forename: P A
authors.initials: PA
authors.lastname: Grant
authors.forename: B J
authors.initials: BJ
authors.lastname: Hosking
authors.forename: A R
authors.initials: AR
authors.lastname: Egan
authors.forename: P C
authors.initials: PC
authors.lastname: Owens
mesh_terms: D000375:Aging / Q000378:metabolism; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000032:analysis / Q000378:metabolism; D008297:Male; D012737:Sex Factors; D012756:Sheep / Q000254:growth & development* / Q000378:metabolism*; D013002:Somatomedins / Q000032:analysis / Q000378:metabolism*; D014886:Weaning
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D013006:Growth Hormone