title: Peripheral retinal neovascularization and retinal vascular occlusion associated with activated protein C resistance.
abstract: OBJECTIVE
  To describe a patient with peripheral retinal neovascularization and vascular occlusion associated with activated protein C resistance.
  
  
  METHODS
  Case report. A 63-year-old woman was examined for acute loss of vision in both eyes. She was noted to have macular edema in both eyes as well as a macular branch vein occlusion in the right eye and a central retinal vein occlusion in the left eye. Peripheral retinal neovascularization was present in both eyes.
  
  
  RESULTS
  Extensive systemic evaluation disclosed a heterozygous state for the factor V Leiden indicating activated protein C resistance.
  
  
  CONCLUSIONS
  Activated protein C resistance may be associated with peripheral retinal neovascularization.
authors.affiliation: Wake Forest University Eye Center, Winston-Salem, NC 27157-1033, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Greven
authors.forename: A B
authors.initials: AB
authors.lastname: Wall
mesh_terms: D004789:Enzyme Activation; D005165:Factor V / Q000235:genetics; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics; D011486:Protein C / Q000378:metabolism*; D015356:Retinal Artery Occlusion / Q000201:enzymology* / Q000235:genetics; D015861:Retinal Neovascularization / Q000201:enzymology* / Q000235:genetics; D012170:Retinal Vein Occlusion / Q000201:enzymology* / Q000235:genetics
chemical_list: D011486:Protein C; C095381:factor V Leiden; D005165:Factor V