title: [Immunohistochemical studies of nonsecreting pancreatic islet cell tumors secreting many hormones].
abstract: To observe the distribution of multiple hormones in nonsecreting islet cell tumors of the pancreas and to study their histogenesis, 9 pancreas nonsecreting islet cell tumor cases were studies using 12 kinds of antisera. The results showed that 4 cases were positive for insulin, 6 for glucagon, 1 for gastrin, 6 for somatostatin, 1 for gastrin 5 for calcitonin, 7 for neurotensin, 4 for ACTH, 3 for TSH, 5 for FSH and 2 for LH. It is therefore confirmed that these tumors synthesize and secrete peptide hormones and glycoprotein hormones. We believe that these endocrine cells originate from primitive multipotential stem cells.
authors.affiliation: Department of Pathology, Qingdao Municipal Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: L
authors.initials: L
authors.lastname: Chen
mesh_terms: D007516:Adenoma, Islet Cell / Q000737:chemistry*; D000293:Adolescent; D000328:Adult; D002116:Calcitonin / Q000032:analysis; D005260:Female; D005640:Follicle Stimulating Hormone / Q000032:analysis; D005934:Glucagon / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007328:Insulin / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000737:chemistry*
chemical_list: D007328:Insulin; D005640:Follicle Stimulating Hormone; D002116:Calcitonin; D005934:Glucagon