Lipid, lipoprotein, and apolipoprotein profiles in active and sedentary men with tetraplegia.
OBJECTIVE
To investigate whether the risk profile of coronary heart disease (CHD) is more favorable in physically active men with tetraplegia compared with sedentary men with tetraplegia.


METHODS
Using a cross-sectional design, the lipid and (apo)lipoprotein concentrations of 11 active and 13 sedentary men with tetraplegia were compared. Regression analysis was applied to investigate the influence of subject characteristics and behavioral factors on the risk profile of CHD.


METHODS
Total plasma cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, apolipoprotein-A1 (ApoA1), and apolipoprotein-B (ApoB) concentrations were determined. Low-density lipoprotein cholesterol (LDL-C) and the ratios TC/HDL-C, LDL-C/HDL-C, ApoA1/ApoB, and HDL-C/ApoA1 were calculated.


RESULTS
A significantly higher HDL-C and ApoA1/ApoB and lower TC/HDL-C were found in the active group. Age and body mass index were important determinants of the lipids and (apo)lipoproteins. Sport activity was the only significant determinant of HDL-C.


CONCLUSIONS
Results suggest a positive influence of sport activity on HDL-C in men with tetraplegia, which may reduce the risk of CHD.
Dallmeijer
A J
AJ
Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit Amsterdam, The Netherlands.
Hopman
M T
MT
van der Woude
L H
LH
D000203:Activities of Daily Living; D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D003430:Cross-Sectional Studies; D015444:Exercise; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011782:Quadriplegia / Q000378:metabolism* / Q000534:rehabilitation*; D012044:Regression Analysis; D012307:Risk Factors
D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins