Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells.
Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B.
Lokensgard
J R
JR
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minnesota 55404, USA.
Gekker
G
G
Hu
S
S
Arthur
A F
AF
Chao
C C
CC
Peterson
P K
PK
D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000821:virology*; D002478:Cells, Cultured; D003975:Diazepam / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D016328:NF-kappa B / Q000187:drug effects
D014151:Anti-Anxiety Agents; D000956:Antigens, Viral; D016328:NF-kappa B; D003975:Diazepam