title: A synthetic approach to benanomicin A. 2. Synthesis of the substituted 5,6-dihydrobenzo[a]naphthacenequinone.
abstract: The key intermediate tri-substituted alpha-tetralone (8) has been synthesized, either via tandem Michael addition-Dieckmann condensation reaction between dienolate and methyl crotonate in a low yield or via Barton's radical decarboxylation of diester (9) without 4-dimethylaminopyridine in 75% yield, and applied to the synthesis of the substituted 5,6-dihydrobenzo[a]naphthacenequinone.
authors.affiliation: Institute of Microbial Chemistry, M. C. R. F., Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishizuka
authors.forename: S
authors.initials: S
authors.lastname: Hirosawa
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: D
authors.initials: D
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D000095643:Pradimicins and Benanomicins
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C056805:benanomicin A; D000095643:Pradimicins and Benanomicins