[A case report of preoperative intra-arterial infusion chemotherapy for pancreatic head carcinoma].
Intra-arterial infusion chemotherapy was given preoperatively to one patient with pancreatic head adenocarcinoma, in order to prevent local failure after surgery. Under an angiographic procedure, a catheter was placed in the gastroduodenal artery after embolizing the right gastric artery and gastroepiploic artery. Before surgery, 5-fluorouracil (250 mg/day) had been continuously infused for 2 weeks and bolus infusion of methotrexate (25 mg) with 5 micrograms of angiotensin-II had been performed every 3 days. As a results, the maximum diameter of the pancreatic tumor decreased from 3 cm to 2 cm on the CT-Scan. An extended pancreatoduodenectomy with portal vein reconstruction was performed. In histologic study, degenerative tumor cells were shown not only in the primary tumor but also in the extrapancreatic perineural invasion.
Ohigashi
H
H
Dept. of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases.
Ishikawa
O
O
Sasaki
Y
Y
Nakano
H
H
Nakamori
S
S
Kameyama
M
M
Hiratsuka
M
M
Kabuto
T
T
Furukawa
H
H
Yasuda
T
T
Imaoka
S
S
Fujita
M
M
Kuroda
C
C
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000804:Angiotensin II / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D005472:Fluorouracil; D008727:Methotrexate