Prospects for adoptive T cell therapy.
Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte defined tumor antigens, several antigens have been identified and characterized for suitability as target antigens for immunotherapy. The development of innovative strategies to generate T cells targeting these antigens and lessons learned from clinical trials of adoptive immunotherapy of viral diseases should facilitate the design of clinical trials for specific adoptive immunotherapy of cancer.
Yee
C
C
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
Riddell
S R
SR
Greenberg
P D
PD
D000951:Antigens, Neoplasm / Q000235:genetics / Q000276:immunology*; D005544:Forecasting; D006801:Humans; D016219:Immunotherapy, Adoptive; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*
D000951:Antigens, Neoplasm