title: Acquired hypophysitis in adolescence.
abstract: Lymphocytic and granulomatous hypophysitis are rare causes of anterior pituitary dysfunction, diabetes insipidus and hyperprolactinemia. The clinical, radiographic, and laboratory features of hypophysitis in two adolescent girls are presented along with a review of the medical literature. These subjects represent the youngest cases of autoimmune (lymphocytic) and granulomatous hypophysitis reported to date. While hypophysitis remains an unusual cause of pituitary dysfunction, it may also occur in early adolescence.
authors.affiliation: Department of Pediatrics, Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: Heinze
authors.forename: B B
authors.initials: BB
authors.lastname: Bercu
mesh_terms: D000293:Adolescent; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000628:therapy; D002648:Child; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008279:Magnetic Resonance Imaging; D010900:Pituitary Diseases / Q000209:etiology* / Q000276:immunology* / Q000628:therapy; D014057:Tomography, X-Ray Computed