title: Contribution of immunological mechanism in a case of ochronotic arthropathy.
abstract: We have studied cell mediated and humoral response on the synovial fluid and peripheral blood of a 60-year-old man affected by ochronosis. Results showed raised percentages of CD3+, CD8+, HLA-DR+ and CD25+ T cells, presence of TNF, enhanced levels of immunoglobulins and low levels of C3 in the synovial fluid, and a higher rate of HLA-DR+ and CD25+ T lymphocytes in peripheral blood. These data suggest a possible role of immunological response the evolution of an ochronotic arthropathy.
authors.affiliation: II Medical Clinic, University of Rome, La Sapienza, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Aliberti
authors.forename: I
authors.initials: I
authors.lastname: Pulignano
authors.forename: M
authors.initials: M
authors.lastname: Proietta
authors.forename: L
authors.initials: L
authors.lastname: De Michele
authors.forename: P
authors.initials: P
authors.lastname: Corvisieri
mesh_terms: D006801:Humans; D007592:Joint Diseases / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009794:Ochronosis / Q000276:immunology*