title: Ovarian cancer risk and history of selected medical conditions linked with female hormones.
abstract: To investigate the role of selected medical conditions on the risk of ovarian cancer, we analysed data from a case-control study. Cases were 971 women below the age of 75 years with histologically confirmed epithelial ovarian cancer, admitted to a network of hospitals including the major teaching and general hospitals in the greater Milan area. Controls were 2758 women admitted to the same network of hospitals for acute, non-gynaecological, non-hormone related, non-neoplastic conditions. Obesity/severe overweight were inversely associated with the risk of ovarian cancer (multivariate relative risk, RR, 0.66, 95% confidence interval, CI, 0.52-0.85). Hyperlipidaemia was also inversely related to ovarian cancer risk, (RR 0.64, 95% CI 0.45-0.89). No relationship emerged between ovarian cancer risk and diabetes (RR 0.80, 95% CI 0.54-1.19), hypertension (RR 0.85, 95% CI 0.68-1.06), thyroid diseases (RR 0.89, 95% CI 0.63-1.13) and cholelithiasis (RR 0.86, 95% CI 0.66-1.12). A decreased frequency of ovarian cancer was seen in women with a history of uterine leiomyomas (RR 0.66, 95% CI 0.47-0.92) and benign ovarian cysts (RR 0.69, 95% CI 0.41-1.13).
authors.affiliation: Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Parazzini
authors.forename: S
authors.initials: S
authors.lastname: Moroni
authors.forename: C
authors.initials: C
authors.lastname: La Vecchia
authors.forename: E
authors.initials: E
authors.lastname: Negri
authors.forename: D
authors.initials: D
authors.lastname: dal Pino
authors.forename: G
authors.initials: G
authors.lastname: Bolis
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002769:Cholelithiasis / Q000150:complications; D048909:Diabetes Complications; D005260:Female; D006728:Hormones / Q000502:physiology*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010051:Ovarian Neoplasms / Q000209:etiology*; D012307:Risk Factors; D013959:Thyroid Diseases / Q000150:complications
chemical_list: D006728:Hormones