[Postpartum myoglobin blood monitoring in newborns. Correlations with renal function in the first 48 hours of life].
BACKGROUND
Myoglobin is a muscular tissue protein, and it is a very early damage index. As the newborn "thin mass" is less than that of the adult and knowing the renal dynamics of this protein clearance, the authors have analyzed the correlation between myoglobinemia and transitory renal failure, which is frequently present in newborns with fetal distress.


METHODS
We examined a random population of 56 newborns (33 eutocic deliveries 14 caeserotomy, 9 various degrees of fetal distress) to which, after having had the parents' informed consent, the microsamples pattern was fixed at 0, 6, 12, 24, 48 hours from birth at the same time of ordinary exams to gauge: myoglobin with nephelometric method, CPK, creatininemia, azotemia and transaminase. The same exams were camed out on the mother at the beginning of labor and after delivery.


RESULTS
We found that the placenta is not permeable to mother myoglobin, at the sixth hour from birth we have the highest value, while CPK is lower to increase, myoglobinemia associated with myoglobin variations.


CONCLUSIONS
Myoglobinemia might be monitored to prevent distressed newborns from transitory renal tubular defect, justifying forced diuresis and urinary alkalosis.
Rizzardi
R
R
Servizio Anestesia e Rianimazione, USSL 58, Ospedale Uboldo, Cernusco SN, (Milano).
Castelli
S
S
Porta
C
C
Vitali
F
F
Minerva
M
M
Della Marta
M E
ME
Raimondi
M
M
D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000502:physiology*; D008991:Monitoring, Physiologic; D009211:Myoglobin / Q000097:blood*
D009211:Myoglobin