[The changes in TNF alpha in plasma, organs and eschar of rats after thermal injury].
The TNF alpha (Tumor Necrosis Factor-alpha) contents in the plasma, five organs (heart, lung, liver, kidney and intestine) and burned skin were measured by ELISA method in Wistar rats with 35% TBSA III degrees. The animals were divided into eight different time groups. The experiment showed that TNF alpha contents were excessively high in early stage of burn (24 hours postburn) in plasma, eschar and the five organs. The contents of TNF alpha in eschar were 27.5-86.7 times higher than that in plasma and the five organs.
Jia
X
X
Burn Center, 304 Hospital of People's Liberation Army, Beijing.
Zhu
Z
Z
Kong
Q
Q
D000818:Animals; D002056:Burns / Q000378:metabolism*; D004285:Dogs; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha