[Aberrant p53 protein expression in oral candidal leukoplakia].
Expression of p53 protein in 17 cases of oral candidal leukoplakia (OCL) was studied by immunohistochemistry. p53 protein was identified in all 17 cases (100%) of OCL, and 78% in control cases. The number of p53 positive cells, determined as in per unit of epithelial length, were higher in OCL with epithelial dysplasia than in those without (P < 0.01). Severe dysplasia had the highest number of p53 positive cells. The mean value of p53 positive cells in OCL with simple epithelial hyperplasia was also higher than that in control group. The results indicate that aberrant p53 protein expression exists in OCL and this may be a biological marker for OCL with epithelial dysplasia.
Gao
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Y
School of Stomatology, Beijing Medical University.
D014408:Biomarkers, Tumor / Q000378:metabolism; D002180:Candidiasis, Oral / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007972:Leukoplakia, Oral / Q000378:metabolism* / Q000382:microbiology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D014408:Biomarkers, Tumor; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53