Targeting the glycosaminoglycan-binding sites on proteins.
Sulfated glycosaminoglycans bind to a wide variety of proteins, and in so doing have important roles in diverse biological processes. Selective mimics or inhibitors of protein-glycosaminoglycan interactions could have broad application in biology and medicine.
Lander
A D
AD
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA.
D000818:Animals; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
D006025:Glycosaminoglycans; D011956:Receptors, Cell Surface; C086020:glycosaminoglycan receptor