Fiber-derived butyrate and the prevention of colon cancer.
Inhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a small-molecule-mediated signaling pathway to explain the suspected anti-colon-cancer properties of fiber-derived butyrate.
Hassig
C A
CA
Howard Hughes Medical Institute, Harvard University, Department of Chemistry, Cambridge, MA 02138, USA. hassig@slsiris. harvard.edu
Tong
J K
JK
Schreiber
S L
SL
D001665:Binding Sites; D002087:Butyrates / Q000627:therapeutic use*; D020148:Butyric Acid; D003110:Colonic Neoplasms / Q000201:enzymology / Q000517:prevention & control*; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000378:metabolism; D004043:Dietary Fiber / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D050981:Erythroid-Specific DNA-Binding Factors; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects; D014407:Tumor Cells, Cultured; D015854:Up-Regulation / Q000187:drug effects
D002087:Butyrates; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D004268:DNA-Binding Proteins; D004043:Dietary Fiber; D004791:Enzyme Inhibitors; D050981:Erythroid-Specific DNA-Binding Factors; D056572:Histone Deacetylase Inhibitors; D014157:Transcription Factors; D020148:Butyric Acid