title: A computing system for the clinical and experimental investigation of cerebrovascular reactivity.
abstract: We present a computing system for the recording and on-line analysis of analogue signals derived from bedside cerebrovascular monitors in different pathophysiological conditions. These include arterial blood pressure and oxygen saturation, end-tidal carbon dioxide concentration, cerebral blood flow velocities using transcranial Doppler ultrasonography, and concentration changes in cerebral oxy- and deoxyhaemoglobin from near infrared spectroscopy. Configuration and analysis adopts arithmetic expressions of different signal processing functions, various statistical properties for each signal, frequency spectrum analysis using fast Fourier transformation, and correlation/cross-correlation. The software offers off-line analysis of non-invasive tests of cerebrovascular reactivity. Several examples of clinical assessment of cerebrovascular reactivity are presented, including cerebral haemodynamic stress tests which employ carbon dioxide, acetazolamide, the breath holding test, leg cuff inflation and deflation, and transient carotid artery compression. Application within the experimental setting with induced haemorrhagic hypotension can also be used.
authors.affiliation: MRC Cambridge Centre for Brain Repair, Addenbrooke's Hospital, University of Cambridge, U.K.
authors.forename: P
authors.initials: P
authors.lastname: Smielewski
authors.forename: M
authors.initials: M
authors.lastname: Czosnyka
authors.forename: W
authors.initials: W
authors.lastname: Zabolotny
authors.forename: P
authors.initials: P
authors.lastname: Kirkpatrick
authors.forename: H
authors.initials: H
authors.lastname: Richards
authors.forename: J D
authors.initials: JD
authors.lastname: Pickard
mesh_terms: D002318:Cardiovascular Diseases / Q000503:physiopathology; D003936:Diagnosis, Computer-Assisted; D006439:Hemodynamics; D006801:Humans; D019095:Point-of-Care Systems; D012984:Software