Calcium and signal transduction in granulocytes.
During activation, blood cells experience changes in intracellular free calcium levels ([Ca2+]i) that are associated with signal transduction events. In granulocytic cells, changes in [Ca2+]i have been associated with multiple functions, including activation of cellular kinases and phosphatases, degranulation, phagosome-lysosome fusion, regulation of cytoskeletal binding proteins, transcriptional control, and modulation of surface receptors. This review discusses the general role played by [Ca2+]i in granulocytic leukocyte signal transduction, with a special emphasis on recent developments in the field of calcium signaling to and from integrins and the regulation of cell adhesion and motility by [Ca2+]i.
Mandeville
J T
JT
Columbia University College of Physicians and Surgeons, New York, NY, USA.
Maxfield
F R
FR
D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002465:Cell Movement; D006098:Granulocytes / Q000502:physiology*; D016023:Integrins / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction
D016023:Integrins; D011956:Receptors, Cell Surface; D010744:Phosphoric Monoester Hydrolases; D002118:Calcium