Strain specific production of a negative regulator of IL-3 (NIL-3): difference in the negative feedback mechanism of hemopoiesis among mouse strains.
The producing cells of the negative regulator of interleukin-3 (NIL-3) were investigated. The 5-fluorouracil-treated bone marrow cells did not produce NIL-3. The bone marrow cells of stem cell-depleted W/WV mouse did not produce the NIL-3, either. The production of NIL-3 was different among mouse strains. Mice of C3H/HeN, A/J and ICR strains produced NIL-3, but the C57BL/6 mice did not produce NIL-3. These results indicate that the negative feedback mechanism of hemopoiesis is different among mouse strains. In the present study, we could not definitely identify the NIL-3 producing cells, although the present results are suggestive that the stem cells in cycle are a NIL-3 producer. Instead, we found that hemopoietic regulatory mechanisms might be different among mouse strains, especially in C57BL/6 mice.
Sugimoto
K
K
Department of Molecular and Cellular Biology, Faculty of Science, Niigata University, Japan.
Jiang
H
H
Takashita
E
E
Inoue
H
H
Kadowaki
S
S
Mori
K J
KJ
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000276:immunology*; D002453:Cell Cycle; D002460:Cell Line; D006410:Hematopoiesis / Q000276:immunology*; D007377:Interleukin-3 / Q000037:antagonists & inhibitors / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D008818:Mice, Neurologic Mutants; D013045:Species Specificity
D007377:Interleukin-3