title: Signaling in unicellular eukaryotes.
abstract: Aspects of intercellular and intracellular signaling systems in cell survival, proliferation, differentiation, chemosensory behavior, and programmed cell death in free-living unicellular eukaryotes have been reviewed. Comparisons have been made with both bacteria and metazoa. The central organisms were flagellates (Trypanosoma, Leishmania, and Crithidia), slime molds (Dictyostelium), yeast cells (Saccharomyces cerevisiae), and ciliates (Paramecium, Euplotes, and Tetrahymena). There are two novel aspects in this review. First, cellular responses are viewed in an evolutionary perspective, rather than from the more prevailing one, in which the unicellular eukaryotes are seen by the mammalian organisms. Second, results obtained with cell cultures in minimal, chemically defined nutrient media at low cell densities where intercellular signaling is strongly reduced are discussed. These results shed light on control mechanisms and their cooperation inside the living cell. Intracellular systems have many common features in unicellular and multicellular organisms.
authors.affiliation: Department of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Denmark.
authors.forename: S T
authors.initials: ST
authors.lastname: Christensen
authors.forename: V
authors.initials: V
authors.lastname: Leick
authors.forename: L
authors.initials: L
authors.lastname: Rasmussen
authors.forename: D N
authors.initials: DN
authors.lastname: Wheatley
mesh_terms: D000818:Animals; D004023:Dictyostelium / Q000502:physiology; D056890:Eukaryota / Q000502:physiology; D005057:Eukaryotic Cells / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000502:physiology; D015398:Signal Transduction