title: [A pathological study of goat multiple organ failure model].
abstract: We succeeded in replication a standardized goat model of multiple organ failure (MOF). In the experimentation, the animals were monitored and supported with facilities pertaining to a human intensive care unit, with constant infusion of LPS into portal vein following trauma and hemorrhagic shock. The main organs of MOF goats were observated by the light microscopy and electronmicroscopy, including the lungs, hearts, livers, kidneys, intestines and spleens. The results showed that there were some areas of spotty and mass necrosis in the organ parenchyma with inflammatory cell infiltration. Our studies suggested that once the clinical multiple organ failure, severe pathological changs occur in organs.
authors.affiliation: 304th Hospital of People's Liberation Army, Beijing.
authors.forename: J
authors.initials: J
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: S
authors.initials: S
authors.lastname: Hu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006041:Goats; D008297:Male; D009102:Multiple Organ Failure / Q000473:pathology*; D014781:Viscera / Q000473:pathology