[The effect of phospholipid liposomes on atherosclerosis and serum lipid in rabbits].
In order to study the effect of oral phospholipid liposomes on regression of atherosclerosis process, serum total cholesterol triglyceride, lipoprotein cholesterol and atherosclerotic lesion on the aorta wall in different groups of 20 New Zealand rabbits were observed. Results showed that phospholipid liposomes could obviously increase high density lipoprorein cholesterol concentration and decrease serum total cholesterol triglyceride and very low density lipoprorein cholesterol concentration. Phospholipid liposomes could also reduce the size of atherosclerotic lesion on the aortic wall. In comparision with the results observed in phospholipid group, there was significant difference (P < 0.05, P < 0.01 or P < 0.001). It suggested that oral phospholipid liposomes could effectively regress atherosclerotic lesion on the arterial wall and regulate serum lipid to reduce cholesterol deposit on the arterial wall in experimental rabbits. It might provide some experimental basis for human being to prevent and treat atherosclerosis.
He
Y
Y
Department of Cardiology, General Hospital of Beijing Command.
Xu
N
N
Liu
X
X
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D008055:Lipids / Q000097:blood*; D008081:Liposomes; D010743:Phospholipids / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D008055:Lipids; D008081:Liposomes; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol