title: Improvements in mechanical bowel preparation for elective colorectal surgery.
abstract: OBJECTIVE
  This study was undertaken to determine whether a mechanical bowel preparation with 2 liters of polyethylene glycol solution combined with a laxative (Group A) increases the acceptability of bowel preparation and reduces discomfort compared with 4 liters of polyethylene glycol solution (Group B).
  
  
  METHODS
  One hundred patients undergoing an elective colorectal resection were included in a prospective, randomized study. Acceptability (nausea, vomiting, abdominal cramps, discomfort from insertion of the nasogastric tube, and anal discomfort) was assessed using visual analog scales. Efficacy of bowel lavage was scored intraoperatively by a blinded surgeon.
  
  
  RESULTS
  Overall acceptability was 5.1 +/- 2.8 in Group A patients and 5.6 +/- 2.6 in Group B patients (P = 0.5). The incidence and visual analog score for nausea, vomiting, anal discomfort, and cramps were not different between groups. Excellent efficacy of bowel preparation was shown in 94 percent of patients in Group A and 84 percent of patients in Group B (P = 0.5). The incidence of septic complications was 2 percent in Group A patients and 12 percent in Group B patients (P = 0.06).
  
  
  CONCLUSIONS
  Because the acceptability of both cleansing regimens were not different, 2 liters of polyethylene glycol plus Prepacol should be preferred because the amount of fluid administered to clean the bowel is reduced and the nasogastric tube can always be avoided.
authors.affiliation: Department of Surgery, Charité, Humboldt University of Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Gründel
authors.forename: W
authors.initials: W
authors.lastname: Schwenk
authors.forename: B
authors.initials: B
authors.lastname: Böhm
authors.forename: J M
authors.initials: JM
authors.lastname: Müller
mesh_terms: D000368:Aged; D001726:Bisacodyl / Q000008:administration & dosage* / Q000009:adverse effects; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D003106:Colon / Q000601:surgery*; D004359:Drug Therapy, Combination; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D007239:Infections / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D010710:Phosphates / Q000008:administration & dosage* / Q000009:adverse effects; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D011183:Postoperative Complications; D011446:Prospective Studies; D012007:Rectum / Q000601:surgery*; D016037:Single-Blind Method; D012996:Solutions
chemical_list: D002400:Cathartics; D010710:Phosphates; D012996:Solutions; C063635:prepacol; D001726:Bisacodyl; D011092:Polyethylene Glycols