Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.
A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.
Posner
G H
GH
Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, U.S.A.
Ploypradith
P
P
Hapangama
W
W
Wang
D
D
Cumming
J N
JN
Dolan
P
P
Kensler
T W
TW
Klinedinst
D
D
Shapiro
T A
TA
Zheng
Q Y
QY
Murray
C K
CK
Pilkington
L G
LG
Jayasinghe
L R
LR
Bray
J F
JF
Daughenbaugh
R
R
D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured
D000962:Antimalarials; D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds