title: [Problems in evaluating the long-term effect of antihypertensive drugs: once again: the trough/peak ratio].
abstract: For the description of the duration of the antihypertensive effect of a drug the term "trough/peak ratio" was introduced. For many drugs corresponding values were published. Because of different methodologies used these values can not be compared directly. Therefore the pharmacokinetic half-life of a drug is-at least today-the more reliable parameter.
authors.forename: G
authors.initials: G
authors.lastname: Hitzenberger
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents