[Inhibitory effect of substance P of caudate nucleus on gastric motility via substantia nigra and dorsal vagal nucleus mediated by vagus nerve].
Effects of lesion of bilateral hypothalamus (LH), substantia nigra and dorsal vagal nucleus as well as their efferent pathway on the inhibition of gastric myoelectric fast wave and gastric motility due to injection of substance P (SP) to caudate nucleus were studied in rats. The experimental results showed that this induced inhibition was independent of the presence of intact LH but abolished by lesioning substantia nigra, dorsal vagal nucleus or vagus nerve. Depletion of sympathetic transmitter by reserpine did not affect the occurrence of the inhibition. Thus, it appears that the gastric inhibitory effect of caudate nucleus SP is mediated via substantia nigra and dorsal vagal nucleus to vagus nerve.
Jing
H
H
Department of Physiology, Dalian Medical University.
Zhang
J
J
Lin
K W
KW
D000818:Animals; D002421:Caudate Nucleus / Q000502:physiology*; D004525:Efferent Pathways / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology*; D008297:Male; D016065:Myoelectric Complex, Migrating; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000502:physiology; D013373:Substance P / Q000494:pharmacology*; D013378:Substantia Nigra / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology*
D013373:Substance P