[Improvement in model of mesangial proliferative glomerulonephritis of rat].
To establish a model of mesangial proliferative glomerulonephritis (MsPGN), we gave Sprague-Dawley rats staphylococcal enterotoxin B (SEB) intravenously twice in different times, bovine serum albumine (BSA) through digestive tract every other day, and Freud's adjuvant subcutaneously twice in different times, respectively. The results showed that measangial cells and matrix in glomeruli of rats began to proliferate at the end of 6th week and this change became obvious at the end of 8th week. The duration of experiment was shorter than that using only SEB, and the change of pathomorphology was stable. The experiment confirms the thesis that mucosal immunization of gastroenteric tract plays an important role in the development of MsPGN.
Liu
Z
Z
Department of Pediatrics, Second Affiliated Hospital, Chengdu.
Zhou
S
S
Tan
J
J
Wang
Z
Z
Wang
Z
Z
Zhang
X
X
Yu
Y
Y
D000818:Animals; D002455:Cell Division; D004195:Disease Models, Animal; D004768:Enterotoxins; D005920:Glomerular Mesangium / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013210:Staphylococcus
D004768:Enterotoxins