Non-Hodgkin lymphoma and Kaposi sarcoma in an eyelid of a patient with acquired immunodeficiency syndrome. Multiple viruses in pathogenesis.
A 36-year-old patient with acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. The histopathologic examination revealed a high-grade diffuse large cell non-Hodgkin lymphoma in continuity with a Kaposi sarcoma. In situ hybridization revealed Epstein-Barr virus in the large cell lymphoma and Kaposi sarcoma-associated herpesvirus in the Kaposi sarcoma lesion. This collision tumor is an unusual presentation of 2 malignant neoplasms in a patient with acquired immunodeficiency syndrome, with in situ hybridization evidence of Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus in the lesion.
Tunc
M
M
Department of Ophthalmology, University of California, San Francisco, USA. mtunc@itsa.ucsf.edu
Simmons
M L
ML
Char
D H
DH
Herndier
B
B
D000328:Adult; D015828:Eye Infections, Viral / Q000209:etiology / Q000473:pathology; D005142:Eyelid Neoplasms / Q000473:pathology / Q000821:virology*; D006566:Herpesviridae Infections / Q000209:etiology* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D017403:In Situ Hybridization; D016483:Lymphoma, AIDS-Related / Q000473:pathology / Q000821:virology*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000473:pathology / Q000821:virology*; D008297:Male; D012333:RNA, Messenger / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D012514:Sarcoma, Kaposi / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000209:etiology* / Q000473:pathology
D012333:RNA, Messenger; D012367:RNA, Viral