Stress ulcer prophylaxis: the case for a selective approach.
Although stress-related mucosal damage is common (and potentially serious) in critically ill patients, the risk of clinically significant gastrointestinal bleeding appears to be confined to patients with certain factors: mechanical ventilation, coagulopathy, multiple trauma, increased intracranial pressure, and multiorgan dysfunction. Because prophylactic therapy also poses risks, we advocate reserving it for patients in these high-risk groups.
Bobek
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MB
PharmD, Department of Pharmacy, Cleveland Clinic Foundation, OH 44195, USA.
Arroliga
A C
AC
D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology / Q000517:prevention & control*; D011379:Prognosis; D013312:Stress, Physiological / Q000150:complications*
D000897:Anti-Ulcer Agents