title: Evidence for a novel gene for familial febrile convulsions, FEB2, linked to chromosome 19p in an extended family from the Midwest.
abstract: Febrile convulsions are a common form of childhood seizure. It is estimated that between 2 and 5% of children will have a febrile convulsion before the age of 5. It has long been recognized that there is a significant genetic component for susceptibility to this type of seizure. Wallace, Berkovic and co-workers recently reported linkage of a putative autosomal dominant febrile convulsion gene to chromosome 8q13-21. We report here another autosomal dominant febrile convulsion locus on chromosome 19p. Linkage analysis in this large multi-generational family gave a maximum pairwise lod score of 4.52 with marker Mfd120 at locus D19S177. Linkage to the chromosome 8 locus was excluded in this family. Haplotype analysis using both affected and unaffected family members indicates that this febrile convulsion gene, which we call FEB2 , can be localized to an 11.7 cM, 1-2 Mb section of chromosome 19p13.3, between loci D19S591 and D19S395.
authors.affiliation: Neurogenetics/Neuropharmacology, Center for Medical Genetics and Marshfield Clinic, Marshfield, WI 54449, USA. johnsone@mfldclin.edu
authors.forename: E W
authors.initials: EW
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Dubovsky
authors.forename: S S
authors.initials: SS
authors.lastname: Rich
authors.forename: C A
authors.initials: CA
authors.lastname: O'Donovan
authors.forename: H T
authors.initials: HT
authors.lastname: Orr
authors.forename: V E
authors.initials: VE
authors.lastname: Anderson
authors.forename: A
authors.initials: A
authors.lastname: Gil-Nagel
authors.forename: P
authors.initials: P
authors.lastname: Ahmann
authors.forename: C G
authors.initials: CG
authors.lastname: Dokken
authors.forename: D T
authors.initials: DT
authors.lastname: Schneider
authors.forename: J L
authors.initials: JL
authors.lastname: Weber
mesh_terms: D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D003294:Seizures, Febrile / Q000235:genetics*; D014481:United States