CD8+ cell-mediated immune responses: relation to disease resistance and susceptibility in lentivirus-infected primates.
Immune responses mediated by CD8+ lymphocytes have been correlated with protection from HIV infection and disease progression in humans and nonhuman primates. The CD8+ cell population is heterogeneous in terms of biological function and phenotype. We have undertaken a review of the current state of knowledge of subtypes of CD8+ cells and their role in immune responses directed to HIV and related primate lentiviruses. Differences in the pathogenesis of lentivirus infections in various primate hosts were examined and the possible roles of the various subpopulations of CD8+ lymphocytes in the resistance and/or susceptibility to lentivirus-related disease were compared.
Buijs
L
L
Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands.
Bogers
W M
WM
Eichberg
J W
JW
Heeney
J L
JL
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology / Q000662:veterinary / Q000821:virology; D015658:HIV Infections / Q000276:immunology* / Q000662:veterinary; D007111:Immunity, Cellular / Q000502:physiology*; D007113:Immunity, Innate; D016180:Lentivirus Infections / Q000276:immunology* / Q000662:veterinary; D017958:Lentiviruses, Primate; D016131:Lymphocyte Subsets / Q000276:immunology; D011323:Primates / Q000276:immunology / Q000821:virology