title: Interferon therapy for Japanese hemophiliacs with chronic hepatitis C.
abstract: Eight Japanese hemophiliacs with chronic hepatitis C (CHC) received interferon (IFN) therapy and four of them (50%) responded completely. Non-responders included 3 double-infected patients: 1 with hepatitis B virus (HBV) and 2 with human immunodeficiency virus-1 (HIV-1). In one of the patients with HIV-1 double infection, the absolute number of CD4+ lymphocytes decreased during IFN therapy. These findings suggest that hemophiliac patients with CHC can respond well to IFN therapy, but in patients who are double-infected with HBV and HIV-1, the indication of IFN therapy should be considered seriously.
authors.affiliation: Department of Pediatrics, Haga Red Cross Hospital, Tochigi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: T
authors.initials: T
authors.lastname: Meguro
authors.forename: S
authors.initials: S
authors.lastname: Takayama
authors.forename: K
authors.initials: K
authors.lastname: Yamada
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015658:HIV Infections / Q000150:complications; D015497:HIV-1; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000628:therapy*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome
chemical_list: D016899:Interferon-beta