Genetic pathways to colorectal cancer.
The first known cancer family would be described today as having hereditary nonpolyposis colorectal cancer, in which, as in familial adenomatous polyposis, the emergence of a malignancy requires a seemingly unlikely sequence of somatic mutations, superimposed on a risk-conveying inheritance. Events identified in the inherited syndromes are proving crucial in learning precisely how nonfamilial tumors develop
Boland
C R
CR
Department of Medicine, University of California, San Diego, USA.
D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D017491:Genes, APC / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D008967:Molecular Biology