title: Cognitive deficits in patients suffering from chronic fatigue syndrome, acute infective illness or depression.
abstract: BACKGROUND
  Patients with chronic fatigue syndrome (CFS) report neuro-psychological symptoms as a characteristic feature. We sought to assess cognitive performance in patients with CFS, and compare cognitive performance and subjective workload experience of these patients with that of two disease comparison groups (non-melancholic depression and acute infection) and healthy controls.
  
  
  METHODS
  A computerized performance battery employed to assess cognitive functioning included tests of continuous attention, response speed, performance accuracy and memory. Severity of mood disturbance and subjective fatigue were assessed by questionnaire.
  
  
  RESULTS
  All patient groups demonstrated increased errors and slower reaction times, and gave higher workload ratings than healthy controls. Patients with CFS and non-melancholic depression had more severe deficits than patients with acute infection. All patient groups reported more severe mood disturbance and fatigue than healthy controls, but patients with CFS and those with acute infection reported less severe mood disturbance than patients with depression.
  
  
  CONCLUSIONS
  As all patients demonstrated similar deficits in attention and response speed, it is possible that common pathophysiological processes are involved. The differences in severity of mood disturbance, however, suggest that the pathophysiological processes in patients with CFS and acute infection are not simply secondary to depressed mood.
authors.affiliation: Inflammation Research Unit, School of Pathology, University of New South Wales, Sydney, Australia. u.vollmer-conna@unsw.edu.au
authors.forename: U
authors.initials: U
authors.lastname: Vollmer-Conna
authors.forename: D
authors.initials: D
authors.lastname: Wakefield
authors.forename: A
authors.initials: A
authors.lastname: Lloyd
authors.forename: I
authors.initials: I
authors.lastname: Hickie
authors.forename: J
authors.initials: J
authors.lastname: Lemon
authors.forename: K D
authors.initials: KD
authors.lastname: Bird
authors.forename: R F
authors.initials: RF
authors.lastname: Westbrook
mesh_terms: D000208:Acute Disease; D000328:Adult; D000339:Affect; D003072:Cognition Disorders / Q000209:etiology*; D003657:Decision Making; D003866:Depressive Disorder / Q000150:complications* / Q000523:psychology; D015673:Fatigue Syndrome, Chronic / Q000150:complications* / Q000523:psychology; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications* / Q000523:psychology; D008297:Male; D011581:Psychological Tests; D016526:Workload