Cracking the carbohydrate code for selectin recognition.
Selectins are central in the inflammatory response; the discovery that they bind to carbohydrate ligands has galvanized carbohydrate chemists to search for inhibitors of the process. Recent progress in identifying and analyzing physiological selectin counter-receptors suggests new approaches to the design of ligands that bind to specific selectins.
Bertozzi
C R
CR
Department of Chemistry, University of California, Berkeley 94720, USA.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002241:Carbohydrates / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D008024:Ligands; D019007:P-Selectin / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D002241:Carbohydrates; D008024:Ligands; D019007:P-Selectin