Vanadium-mediated oxidation of NADH is enhanced by aluminium and inhibited by vitamin E and some copper (II) complexes.
The effect of aluminium on vanadium-mediated oxidation of NADH was examined. The oxidation of NADH was enhanced in the presence of aluminium. The effect was concentration dependent. Vitamin E and copper (II) complexes with superoxide dismutase (SOD)-like activities containing isobutyric acid hydrazine were tested for their effect on the vanadium-mediated oxidation of NADH. The stimulatory effect of aluminium was decreased upon addition of different concentrations of vitamin E and copper (II) complexes. These results indicate that the biological toxicity of aluminium may be attributed to its enhancement of the production of superoxide radicals (O2.-) in association with the accumulation of other trace elements such as vanadium.
Abou-Seif
M A
MA
Chemistry Department, Faculty of Science, Mansoura University, Egypt.
D017607:Aluminum Compounds / Q000737:chemistry* / Q000633:toxicity; D003300:Copper / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D009243:NAD / Q000737:chemistry*; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry*; D017968:Vanadium Compounds / Q000737:chemistry* / Q000633:toxicity; D014810:Vitamin E / Q000737:chemistry*
D017607:Aluminum Compounds; D016166:Free Radical Scavengers; D017968:Vanadium Compounds; D009243:NAD; D013481:Superoxides; D014810:Vitamin E; D003300:Copper; D013482:Superoxide Dismutase