title: [Monoarthritis of the knee as an isolated manifestation of paracoccidioidomycosis].
abstract: Osteoarthritis in paracoccidioidomycosis has been rarely reported. The present case describes a 36-"year"-old woman, with chronic monoarthritis in the knee lasting 4 years. The diagnosis was achieved only after synovial biopsy, by anatomopathological examination showing granulomatous reaction with a large number of the characteristic "pilot wheel"Paracoccidioides brasiliensis yeast cells. Specific therapy, initially with ketoconazole and followed by cotrimoxazole led to complete functional recovery of the compromised joint. No other affected site was detected by various propaedeutic methods, including computed axial tomography of the thorax and abdomen. The authors emphasize the rarity of the case and discuss its possible pathophysiology.
authors.affiliation: Centro de Ciências Biomédicas, Universidade Federal de Uberlândia, MG.
authors.forename: M T
authors.initials: MT
authors.lastname: Silvestre
authors.forename: M S
authors.initials: MS
authors.lastname: Ferreira
authors.forename: A S
authors.initials: AS
authors.lastname: Borges
authors.forename: A
authors.initials: A
authors.lastname: Rocha
authors.forename: G M
authors.initials: GM
authors.lastname: de Souza
authors.forename: S A
authors.initials: SA
authors.lastname: Nishioka
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage; D007719:Knee Joint / Q000382:microbiology; D008875:Middle Aged; D010228:Paracoccidioides / Q000302:isolation & purification; D010229:Paracoccidioidomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D013583:Synovial Membrane / Q000382:microbiology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D007654:Ketoconazole