[Biochemical parameters in the diagnosis of nephrotoxicity of antineoplastic chemotherapy in children].
The investigation was concerned with the role of enzymouria in the assessment of nephrotoxic effects identified in 19 children with malignant solid tumors who received cisplatin polychemotherapy in a dose of 100 mg/sq.m or iphosphamide in a dose 9 g/sq.m. Chemotherapy application was followed by a persistent hyperenzymouria involving significantly higher levels of N-acetyl-beta-D-hexosaminidase, beta-glutamyl transferase and alanine aminopeptidase in the urine, as compared with basal indices. Iphosphamide treatment showed significantly higher levels of enzymouria than those in cisplatin-treated patients. Higher than normal creatinine and urea concentrations were recorded only in 2 out of 9 patients receiving iphosphamide. Enzymouria evaluation was shown to be an effective method of nephrotoxic diagnosis.
Liubimova
N V
NV
Kumykova
Zh Kh
ZhKh
Kushlinskiĭ
N E
NE
Kasumov
Ch M
ChM
Durnov
L A
LA
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000009:adverse effects; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000652:urine*; D051437:Renal Insufficiency / Q000097:blood* / Q000139:chemically induced / Q000652:urine*; D014508:Urea / Q000097:blood / Q000652:urine
D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D014508:Urea; D003404:Creatinine; D002945:Cisplatin; D007069:Ifosfamide