Strategies for the design of minor groove binders: a re-evaluation based on the emergence of site-selective carbohydrate binders.
Studies on minor groove binders provide new insights into DNA structure and recognition, information that may in the future serve as the basis for the design of synthetic binders targeted to particular minor groove sites. Carbohydrate-based minor groove binders are emerging as a particularly interesting and important class of ligands for DNA.
Kahne
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Department of Chemistry, Princeton University, NJ 08544-1009, USA.
D001665:Binding Sites; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D008024:Ligands
D002241:Carbohydrates; D008024:Ligands; D004247:DNA