Effect of acadesine on myocardial ischaemia in patients with coronary artery disease.
Acadesine, an adenosine regulating agent, attenuates the adverse effects of ischaemia on ventricular function in animals. This study examined its influence on pacing-induced ischaemia in 47 patients undergoing coronary angiography. After 15 min of recovery from control pacing, an infusion of acadesine (5, 10, 20, 50 mg/kg i.v.) was commenced and after a further 15 min the protocol was repeated with the infusion continued. At higher doses, minor beneficial effects on ejection fraction and myocardial lactate metabolism were observed. Haemodynamics were unaffected. Systemic lactate rose in relation to acadesine, up to 60% (P < 0.001 versus placebo). The data may indicate that acadesine stimulates anaerobic glycolysis in man.
de Jonge
R
R
Cardiochemical Laboratory, Thoraxcentre EE2371, COEUR, Erasmus University, Rotterdam, The Netherlands.
Macleod
D C
DC
Suryapranata
H
H
van Es
G A
GA
Friedman
J
J
Serruys
P W
PW
de Jong
J W
JW
D000328:Adult; D000368:Aged; D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006328:Cardiac Catheterization; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D012263:Ribonucleosides / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000187:drug effects
D012263:Ribonucleosides; D019344:Lactic Acid; D000620:Aminoimidazole Carboxamide; C011651:acadesine