[Effects of hydrogen sulfide containing gas condensate on the hepatic microsomal monooxygenase system].
Chronic action of different xenobiotics which form a part of condensed hydrogen sulphide-containing gas causes substantial changes in the activity of xenobiotic metabolic enzymes, which is suggestive of the damaged hepatic microsomal monooxygenase system. As the rate of biotransformation becomes higher, there are increases in the activity of microsomal monooxygenases and in the generation of active oxygen forms and hydrogen peroxide, by impairing antiradical and antiperoxide mechanisms. The experimentally used concentration of substances as constituents of condensed gas corresponds to the maximum acceptable air concentration of in the working area of gas-refining plants, but the functional features of the body's detoxifying system--the hepatic monooxygenase system should be taken into account while developing preventive measures of occupational diseases.
Boev
V M
VM
Nikonorov
A A
AA
Perepelkin
S V
SV
Filippov
V K
VK
D000395:Air Pollutants, Occupational / Q000493:pharmacokinetics*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003580:Cytochromes / Q000378:metabolism; D006862:Hydrogen Sulfide / Q000493:pharmacokinetics*; D008658:Inactivation, Metabolic; D015227:Lipid Peroxidation; D008297:Male; D008452:Maximum Allowable Concentration; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
D000395:Air Pollutants, Occupational; D003580:Cytochromes; D017382:Reactive Oxygen Species; C013464:cytochrome P420; D003577:Cytochrome P-450 Enzyme System; D006862:Hydrogen Sulfide