[Comparison of antihypertensive and metabolic effects of lisinopril 20 mg/hydrochlorothiazide 12.5 mg fixed combination and captopril 50 mg/hydrochlorothiazide 25 mg fixed combination].
The antihypertensive and metabolic effects of lisinopril 20 mg/hydrochlorothiazide 12.5 mg in fixed combination were compared with those of captopril 50 mg/hydrochlorothiazide 25 mg in fixed combination in a double-blind clinical trial. After a 3-week placebo run-in period, two parallel groups of hypertensive patients (188 patients in total) each received one treatment once a day for 6 weeks. Blood pressure was measured with a mercury sphygmomanometer and on two occasions by 24 h ambulatory blood pressure monitoring (ABPM). Results indicate that both treatments have similar effects on casual blood pressure measurements, while ABPM recordings show that the lisinopril 20 mg/hydrochlorothiazide 12.5 mg combination is more effective during the last period of the dosing interval. Lisinopril 20 mg/hydrochlorothiazide 12.5 mg as combination antihypertensive treatment does not induce alterations in serum potassium and triglycerides.
Milon
H
H
Service de Cardiologie, Hôpital de la Croix Rousse, Lyon, France.
Baleydier
A
A
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D004232:Diuretics; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000494:pharmacology*; D017706:Lisinopril / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004232:Diuretics; D004338:Drug Combinations; D049993:Sodium Chloride Symporter Inhibitors; D014280:Triglycerides; D006852:Hydrochlorothiazide; D002216:Captopril; D017706:Lisinopril; D011188:Potassium