title: The technetium white cell scan as an initial imaging investigation for evaluating suspected childhood inflammatory bowel disease.
abstract: BACKGROUND
  The technetium white cell scan (WCS) may be a useful investigation for patients with inflammatory bowel disease (IBD). In a retrospective study we assessed the use of the WCS as an initial imaging investigation in evaluating children with suspected IBD.
  
  
  METHODS
  Over a 3-year period, 60 WCS were performed on 55 patients (25 boys, median age 12.1 years, age range 1.5-18 years) with known or suspected IBD. There were two clinical groups: those with previously diagnosed IBD (histologically and radiologically) and in clinical relapse (13 patients), and newly presenting patients with suspected IBD (42 patients).
  
  
  RESULTS
  Eighteen scans were performed on the 13 patients presenting with relapse. Seventeen were positive and one patient, subsequently shown to have an inactive stricture, had a negative scan. Seven of the 42 newly presenting patients had abnormal scans, confirmed to be due to IBD by a combination of histology and barium examinations. Of the remaining 35 scans, three were abnormal and 32 were normal. None of these patients were subsequently proven to have IBD. These results show that in detecting active IBD, a positive WCS has a 100% sensitivity (24/24) and a 91% specificity (32/35) in the diagnosis of IBD.
  
  
  CONCLUSIONS
  Our results show that the WCS is very useful as an initial imaging investigation in evaluating patients with suspected IBD to select patients for further investigation.
authors.affiliation: Department of Child Health, University Hospital of Wales, Cardiff, United Kingdom.
authors.forename: D B
authors.initials: DB
authors.lastname: Shah
authors.forename: M
authors.initials: M
authors.lastname: Cosgrove
authors.forename: J I
authors.initials: JI
authors.lastname: Rees
authors.forename: H R
authors.initials: HR
authors.lastname: Jenkins
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging*; D007553:Isotope Labeling; D007962:Leukocytes; D008297:Male; D011877:Radionuclide Imaging; D012008:Recurrence; D012189:Retrospective Studies; D019690:Technetium Tc 99m Exametazime
chemical_list: D019690:Technetium Tc 99m Exametazime