title: [Organic personality disorder: response to carbamazepine].
abstract: Organic Personality Disorder is a clinical diagnosis included in ICD-10 classification and also, under a different name, in DSM-IV. Many different treatments have been proposed to improve this condition, carbamazepine being one of them. A case report is presented of a 28 years old patient who, six years before, had suffered a severe brain injury in a car accident. From then on, an intensification of previous personality traits could be observed besides sexual exhibitionism, promiscuity, aggressive episodes, suspiciousness and low impulse control. A chaotic socio-familial situation induced two psychiatric admissions. The patient was initially treated with neuroleptics, benzodiazepines and antidepressants, with no response. Treatment with carbamazepine was then started, reaching a dose of 1,200 mg/day and maintaining plasma levels of 8.8 mcg/ml. After two months of this treatment a marked improvement was observed with absence of exhibitionistic behavior and aggressive episodes, a tendency towards normalization of mood and anxiety, stabilization of his social and family relationships and starting some paid work.
authors.affiliation: Servicio de Psiquiatría, Hospital de Basurto, Bilbao.
authors.forename: P
authors.initials: P
authors.lastname: Muñoz
authors.forename: M A
authors.initials: MA
authors.lastname: González Torres
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000188:drug therapy*; D010554:Personality Disorders / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D002220:Carbamazepine