In-vitro photobactericidal activity of aminoacridines.
The toxicities of several aminoacridines were measured against pathogenic strains of both Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) organisms. In several cases, illumination at a light dose of 6.3 J/cm2 resulted in considerable decreases in the minimum lethal drug concentrations required, giving up to 50-fold increases in bactericidal activity. Derivatives of 9-aminoacridine (aminacrine) exhibited phototoxicity against one or more of the test organisms, but the established photosensitizing acridines proflavine and acridine orange were photobactericidal against all strains.
Wainwright
M
M
Department of Chemistry, University of Central Lancashire, Preston, UK. m.wainwright@uclan.ac.uk
Phoenix
D A
DA
Marland
J
J
Wareing
D R
DR
Bolton
F J
FJ
D000609:Aminoacridines / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008027:Light; D017319:Photosensitizing Agents / Q000494:pharmacology*
D000609:Aminoacridines; D017319:Photosensitizing Agents