title: A comparison of sevoflurane and isoflurane for short-term anesthesia in polecats (Mustela eversmanni).
abstract: Twenty-four Siberian polecats (Mustela eversmanni) from 12 litters were anesthetized with either inhaled sevoflurane or isoflurane. With 7% delivered sevoflurane and 5% delivered isoflurane, time to loss of righting reflex (mean +/- SE) with sevoflurane (1.9 +/- 0.1 min) was significantly shorter compared with isoflurane (2.6 +/- 0.1 min). During maintenance at a light plane of anesthesia, systolic arterial pressure was significantly higher with sevoflurane (83 +/- 2 mm Hg) compared with isoflurane (66 +/- 2 mm Hg), and heart rate was significantly lower with sevoflurane (191 +/- 3 beats/min) compared with isoflurane (204 +/- 3 beats/min). There was no difference in respiratory rate jugular venous pH, pCO3, HCO3-, base excess, or recovery of righting reflex. Induction of anesthesia is more rapid and blood pressure is better maintained with sevoflurane compared with isoflurane; therefore, sevoflurane may be less stressful and safer. Inhaled sevoflurane should be an appropriate anesthetic for black-footed ferrets (Mustela nigripes) in laboratory and field conditions.
authors.affiliation: Department of Clinical Sciences, Colorado State University, Fort Collins 80523, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Gaynor
authors.forename: J
authors.initials: J
authors.lastname: Wimsatt
authors.forename: C
authors.initials: C
authors.lastname: Mallinckrodt
authors.forename: D
authors.initials: D
authors.lastname: Biggins
mesh_terms: D000704:Analysis of Variance; D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D002335:Carnivora / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004987:Ethers; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D007530:Isoflurane; D016014:Linear Models; D008297:Male; D008738:Methyl Ethers; D011897:Random Allocation; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D000077149:Sevoflurane; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane