P53 role in DNA repair and tumorigenesis.
The p53 oncosuppressor is the gene which has been found to be most frequently altered in human cancers. How the p53 gene contributes to tumor induction and progression is presently being investigated by numerous researchers whose specialties range from basic science to clinics. This is a brief overview of the hypotheses on p53 role in tumorigenesis and the possible use of p53 analyses in tumor prognosis and therapy.
Soddu
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Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Rome, Italy.
Sacchi
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D004260:DNA Repair / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D016159:Tumor Suppressor Protein p53