Use of a five-compartment closed model to describe the effects of ethanol inhalation on the transport and elimination of injected pyruvate in the rat.
A five-compartment closed model was established using the system of differential equations. The completely analytical solution of a five-compartment closed model was found using the Laplace transform. 2-[14C]Pyruvate kinetics were studied in rats without and with inhalation of vaporized ethanol, and were modelled by the five-compartment closed model, i.e. injected site, blood, eliminated 14CO2 in air, eliminated 14C in urine and faeces. The kinetic parameters were estimated using the analytical solution of the five-compartment closed model to fit eliminated 14CO2, and 14C in urine and faeces simultaneously. The compartmental analysis showed that the inhalation of vaporized ethanol can increase 2-[14C]pyruvate trans-membrane, trans-tissue processes and oxidation rate. The model developed is useful for general pharmacokinetic and toxicokinetic analysis as well as for studies on ethanol.
Wu
G
G
Department of Biochemistry, Faculty of Biology, Odessa State University, Ukraine.
D000280:Administration, Inhalation; D000818:Animals; D001702:Biopharmaceutics; D002245:Carbon Dioxide / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D008433:Mathematics; D008956:Models, Chemical; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats
D002250:Carbon Radioisotopes; D011773:Pyruvates; D002245:Carbon Dioxide; D000431:Ethanol