title: Histological evaluation of destructive monoarthropathy in mixed connective tissue disease.
abstract: The synovium from a patient with mixed connective tissue disease and destructive ankle monoarthritis was studied in detail to determine its immunohistological characteristics. Fibrinoid necrotic tissue on the surface of the synovium, multi-layered lining cells, increased numbers of capillaries, interstitial edema, infiltration of macrophages, relatively small numbers of lympho-plasma cells and polymorphonuclear leukocytes, scattered bone fragments, and multinucleated giant cells were observed. Many cells in the lining and sublining area were positive for CD68 and MAC387. Lower layers of increased lining cells which had a spindle shape were positively stained with anti-HLA-DR antibody. The small arteries in the deeper part of the synovium revealed obstruction or highly stenotic change. These findings suggest that obstructive circulatory disturbance due to endothelial injury might influence the progression of arthritis.
authors.affiliation: Division of Clinical Immunology, International Medical Center of Japan, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fujinami
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Okawa-Takatsuji
authors.forename: L
authors.initials: L
authors.lastname: Kotajima
authors.forename: M
authors.initials: M
authors.lastname: Kinoshita
authors.forename: M
authors.initials: M
authors.lastname: Sumiya
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Himeno
authors.forename: S
authors.initials: S
authors.lastname: Aotsuka
mesh_terms: D000328:Adult; D000843:Ankle Joint / Q000000981:diagnostic imaging / Q000473:pathology*; D015703:Antigens, CD / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology; D001168:Arthritis / Q000150:complications / Q000276:immunology / Q000473:pathology*; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D008264:Macrophages / Q000276:immunology; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D011859:Radiography; D013583:Synovial Membrane / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D013585:Synovitis / Q000150:complications / Q000276:immunology / Q000473:pathology; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D006684:HLA-DR Antigens; C067980:CD68 antigen, human; D000097382:CD68 Molecule