title: The design, synthesis and transmembrane transport studies of a biomimetic sterol-based ion channel.
abstract: A model sterol-based ion channel was rationally designed and synthesized. The potential ion channel is comprised of a tartrate-derived crown ether to which six steroids are appended. Macromolecule 1a was incorporated into phospholipid vesicles and shown to facilitate the transmembrane transport of sodium and lithium ions using alkali metal NMR spectroscopy.
authors.affiliation: Department of Chemistry, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Pechulis
authors.forename: R J
authors.initials: RJ
authors.lastname: Thompson
authors.forename: J P
authors.initials: JP
authors.lastname: Fojtik
authors.forename: H M
authors.initials: HM
authors.lastname: Schwartz
authors.forename: C A
authors.initials: CA
authors.lastname: Lisek
authors.forename: L L
authors.initials: LL
authors.lastname: Frye
mesh_terms: D004988:Ethers, Cyclic / Q000737:chemistry; D007473:Ion Channels / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines / Q000737:chemistry; D013261:Sterols / Q000737:chemistry*; D013644:Tartrates / Q000737:chemistry
chemical_list: D004988:Ethers, Cyclic; D007473:Ion Channels; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D013261:Sterols; D013644:Tartrates; C029768:tartaric acid