Hormonal response during a fenfluramine-associated panic attack.
Secretion curves for prolactin, cortisol, TSH, and GH from a 37-year old woman with dysthymia and panic disorder with agoraphobia were determined one day prior to (day I), and during a panic attack (day II) associated with an oral dose of 60 mg dl-fenfluramine, a drug known to increase anticipatory anxiety. The increased cortisol secretion observed is discussed in relation to the hormonal correlates of anxiety and the possible role of depression, dl-fenfluramine, and serotonergic receptor sensitivity.
Vieira
A H
AH
Departamento de Psiquiatria LIM-23, Faculdade de Medicina, Universidade de São Paulo, Brasil. ahgvfilh@usp.br
Ramos
R T
RT
Gentil
V
V
D000328:Adult; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects*; D006728:Hormones / Q000378:metabolism*; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D016584:Panic Disorder / Q000097:blood* / Q000139:chemically induced; D011388:Prolactin / Q000378:metabolism*; D018490:Serotonin Agents / Q000009:adverse effects*
D006728:Hormones; D018490:Serotonin Agents; D019382:Human Growth Hormone; D005277:Fenfluramine; D011388:Prolactin