[Observation of relationship between function and structure of experimental pulmonary artery hypertension in rats and inhibitory effect of garlicin and other herbal medicines].
The paper deals with the treatment of the pulmonary artery hypertention in rats caused by monocrotaline with garlicin, liqustrazine and berbamine and studies the relationship between the function and structure of pulmonary artery and pulmonary artery hypertension before and after use of hypotensive agents. The results show that there is a close relationship between the function and structure of pulmonary artery and pulmonary hypertension, and the inhibitory effect of garlicin is the strongest among the three herbal medicines. The pathogenesis is also studied.
Wang
B
B
Harbin Medical University.
Cui
S
S
Yang
B
B
Zhou
C
C
Ding
W
W
D000470:Alkaloids / Q000494:pharmacology; D000498:Allyl Compounds; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D044182:Benzylisoquinolines; D001794:Blood Pressure / Q000187:drug effects*; D004220:Disulfides / Q000494:pharmacology*; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D016686:Monocrotaline; D011651:Pulmonary Artery / Q000648:ultrastructure*; D011719:Pyrazines / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology
D000470:Alkaloids; D000498:Allyl Compounds; D000959:Antihypertensive Agents; D044182:Benzylisoquinolines; D004220:Disulfides; D011719:Pyrazines; D014665:Vasodilator Agents; C028009:diallyl disulfide; D016686:Monocrotaline; C027870:berbamine; C017953:tetramethylpyrazine