Adrenocortical adenoma--an unusual presentation with hypersecretion of oestradiol, androgens and cortisol.
We describe a 6 year-old boy who presented with bilateral gynaecomastia, pseudoprecocious puberty and facial features suggestive of Cushing's syndrome. The underlying pathology was a right adrenocortical adenoma which was secreting oestradiol, androgens and cortisol. All the biochemical abnormalities normalised within one week of right adrenalectomy. To our knowledge this combination of hormones produced by an adrenocortical adenoma is particularly unusual.
Balakumar
T
T
Division of Paediatric Endocrinology, St. Bartholomew's Hospital, London, U.K.
Perry
L A
LA
Savage
M O
MO
D000236:Adenoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D000315:Adrenalectomy; D000728:Androgens / Q000378:metabolism*; D002675:Child, Preschool; D004958:Estradiol / Q000378:metabolism*; D006177:Gynecomastia / Q000209:etiology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D011629:Puberty, Precocious / Q000209:etiology
D000728:Androgens; D004958:Estradiol; D006854:Hydrocortisone