[T-cell receptor gene rearrangement analysis of midline malignant reticulosis: a PCR study of 14 cases].
Using PCR method, we analyzed the gene rearrangement of T-cell receptor chain (TCR-beta) in 14 cases of midline malignant reticulosis (MMR). Our results showed that there were non-germline, monoclonal rearrangements of TCR-beta in 12 of 14 cases of MMR (85.7%). In contrast, the same rearrangement pattern was found only in 6 of 10 cases of lymph node based T-cell lymphoma. The cases of reactive lymphoid hyperplasia were of a polyclonal rearrangement pattern. This study suggests that MMR is a monoclonal T-cell neoplasm and PCR method is a rapid, facilitated and useful method for the detection of clonalities of T-cell proliferations.
Li
G
G
Department of Pathology, First Affiliated Hospital, Chengdu.
Liu
W
W
Yang
X
X
Li
F
F
D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D016399:Lymphoma, T-Cell / Q000235:genetics*; D016133:Polymerase Chain Reaction