title: [Morphology and contrast enhancement of ductal carcinoma in situ in dynamic 1.0 T MR mammography].
abstract: OBJECTIVE
  The detectability with magnetic resonance mammography (MR-M) of non-invasive ductal carcinoma in situ (DCIS), its morphology, and patterns of contrast enhancement were studied.
  
  
  METHODS
  A total of 849 MR-M examinations were performed in 741 patients using a dynamic, contrast-enhanced FLASH 3D sequence at 1.0 T. Surgical breast biopsies were obtained in 332 cases. Histological work-up confirmed 164 carcinomas, including 20 DCIS.
  
  
  RESULTS
  Of 20 DCIS, 14 were correctly diagnosed by MR-M on the basis of focal increase of signal intensity. In two cases (10%), no increase of signal intensity was observed. In another three cases (15%), multifocal enhancement lead to a false-negative diagnosis. In one case (5%), DCIS was a random finding in a patient diagnosed and treated for adjacent phylloides tumour. The sensitivity of MR-M was 70%. 4 (20%) of the DCIS did not show microcalcifications at conventional mammography and were only detected at MR-M. The sensitivity of conventional mammography also amounted to 70%. However, the combination of both imaging methods increased sensitivity to 90%.
  
  
  CONCLUSIONS
  Ductal carcinoma in situ is not reliably detectable by MR-mammography alone due to lack of a uniform pattern of enhancement.
authors.affiliation: Institut für Radiologische Diagnostik, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München.
authors.forename: H
authors.initials: H
authors.lastname: Sittek
authors.forename: M
authors.initials: M
authors.lastname: Kessler
authors.forename: A F
authors.initials: AF
authors.lastname: Heuck
authors.forename: T
authors.initials: T
authors.lastname: Bredl
authors.forename: C
authors.initials: C
authors.lastname: Perlet
authors.forename: I
authors.initials: I
authors.lastname: Künzer
authors.forename: A
authors.initials: A
authors.lastname: Lebeau
authors.forename: M
authors.initials: M
authors.lastname: Untch
authors.forename: M
authors.initials: M
authors.lastname: Reiser
mesh_terms: D001706:Biopsy; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000473:pathology*; D003287:Contrast Media; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA