[A study on the effect of emodin on smooth muscle cell proliferation].
By using smooth muscle cell (SMC) culture in vitro and H3-TdR incorporation technique, we tested the effect of Emodin on SMC proliferation in three groups: (1) Normal rabbit iliac artery, (2) atherosclerotic rabbit iliac artery, (3) atherosclerotic rabbit iliac artery after PTA. These data indicated: Emodin has antiproliferative effect on SMC, which is dose dependent; it blocks the transition of SMC cycle from G0 to S. In PTA group it exerts a more significant proliferative effect than in the normal one. This is a the first report of Emodin's effect on SMC proliferation, it implies that the drug may be used clinically to prevent restenosis after PTCA.
Guo
D
D
Cardiology Department, People's Hospital, Beijing Medical University.
Xu
C
C
Chen
Y
Y
D000800:Angioplasty, Balloon / Q000009:adverse effects; D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology* / Q000628:therapy; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004642:Emodin / Q000494:pharmacology*; D007083:Iliac Artery; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D011817:Rabbits
D004247:DNA; D004642:Emodin