HLA class I specific inhibitory receptors.
All human natural killer cells and some memory T cells express HLA class I receptors, so-called natural killer cell receptors (NKRs), a receptor class that in the past few years has been shown to include several members of the immunoglobulin superfamily and the C-type lectin CD94-NKG2A complex. NKR ligand mediated cross-linking leads to the recruitment and activation of a tyrosine phosphatase involved in downregulating the phosphorylation of effector molecules involved in cell triggering. Thus, NKR engagement leads to the inhibition of different NK and T cell functions.
Moretta
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Dipartimento di Scienze Biomediche e Biotecnologie, Università di Brescia, Genova, Italy. Moretta@sirio.cba.unige.it
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D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007694:Killer Cells, Natural / Q000276:immunology*; D011971:Receptors, Immunologic
D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic