title: Initial experience with clozapine in Woodbridge Hospital.
abstract: OBJECTIVE
  This study was performed to evaluate the efficacy and side-effect profile of the atypical neuroleptic clozapine in local Asian patients with treatment-resistant schizophrenia.
  
  
  METHODS
  Patients were treated with 12 weeks of clozapine after undergoing a washout of all previous neuroleptics. They were assessed weekly on the Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression (CGI) and the Simpson-Angus Scale for Extrapyramidal Side-Effects.
  
  
  RESULTS
  Clinical improvement (according to criteria established a priori) at study end point was shown in 78.9% of the patients. There was no statistical difference in the incidence of the extrapyramidal side-effects at starting and end points. The mean daily dosage was 356.6 mg. The most common adverse effect was hypersalivation.
  
  
  CONCLUSIONS
  Clozapine is effective and well tolerated in local patients with treatment-resistant schizophrenia.
authors.affiliation: Institute of Mental Health/Woodbridge Hospital, Singapore.
authors.forename: K E
authors.initials: KE
authors.lastname: Wong
authors.forename: S A
authors.initials: SA
authors.lastname: Chong
authors.forename: F
authors.initials: F
authors.lastname: Ngui
authors.forename: M
authors.initials: M
authors.lastname: Winslow
authors.forename: G S
authors.initials: GS
authors.lastname: Devan
authors.forename: O K
authors.initials: OK
authors.lastname: Leong
authors.forename: C H
authors.initials: CH
authors.lastname: Choo
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D012846:Singapore; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine