title: Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp.
abstract: A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 microM against the substrate magnesium citrate. The structures of the new antimycins were determined by spectroscopic analyses.
authors.affiliation: Sterling Winthrop Pharmaceuticals Research Division, Malvern, PA 19355, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Barrow
authors.forename: J J
authors.initials: JJ
authors.lastname: Oleynek
authors.forename: V
authors.initials: V
authors.lastname: Marinelli
authors.forename: H H
authors.initials: HH
authors.lastname: Sun
authors.forename: P
authors.initials: P
authors.lastname: Kaplita
authors.forename: D M
authors.initials: DM
authors.lastname: Sedlock
authors.forename: A M
authors.initials: AM
authors.lastname: Gillum
authors.forename: C C
authors.initials: CC
authors.lastname: Chadwick
authors.forename: R
authors.initials: R
authors.lastname: Cooper
mesh_terms: D001275:ATP Citrate (pro-S)-Lyase / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000968:Antimycin A / Q000031:analogs & derivatives*; D005285:Fermentation; D015394:Molecular Structure; D013302:Streptomyces; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000968:Antimycin A; D001275:ATP Citrate (pro-S)-Lyase