A case of fatal hemolytic disease of the newborn associated with-D-/-D-phenotype.
-D- is a rare haplotype that determines D without C, c, E or e, and exalted D activity. The extremely rare homozygote propositi (-D-/-D-) are usually ascertained through their immune antibodies, anti-Rh17 (Hro), which react with red cells of all common Rh phenotypes. The authors experienced the first case in Korea of a woman with -D- phenotype. She had a history of spontaneous abortion, therapeutic termination and red cell transfusion, and at her third pregnancy she delivered a baby with severe hemolytic disease of the newborn. In spite of intensive medical intervention, the baby died of hydrops fetalis. An immune antibody to high incidence Rh antigen, namely anti-Rh17(Hro), was demonstrated in the woman's serum. A family study revealed that the -D- gene complex was present in all its members and one of the woman's sisters was also -D- homozygote. In the serum of this sister, anti-Rh17(Hro) was also present.
Han
K S
KS
Department of Clinical Pathology, Seoul National University College of Medicine, Korea.
Kim
H C
HC
Han
K S
KS
Shim
W S
WS
D004899:Erythroblastosis, Fetal / Q000097:blood / Q000235:genetics* / Q000276:immunology; D017809:Fatal Outcome; D005260:Female; D006239:Haplotypes; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis*; D010375:Pedigree; D010641:Phenotype; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System / Q000235:genetics*
D007518:Isoantibodies; C033242:RH-antibodies; D012204:Rh-Hr Blood-Group System