title: Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.
authors.affiliation: Department of Chemistry, Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Hagen
authors.forename: J V
authors.initials: JV
authors.lastname: Prasad
authors.forename: F E
authors.initials: FE
authors.lastname: Boyer
authors.forename: J M
authors.initials: JM
authors.lastname: Domagala
authors.forename: E L
authors.initials: EL
authors.lastname: Ellsworth
authors.forename: C
authors.initials: C
authors.lastname: Gajda
authors.forename: H W
authors.initials: HW
authors.lastname: Hamilton
authors.forename: L J
authors.initials: LJ
authors.lastname: Markoski
authors.forename: B A
authors.initials: BA
authors.lastname: Steinbaugh
authors.forename: B D
authors.initials: BD
authors.lastname: Tait
authors.forename: E A
authors.initials: EA
authors.lastname: Lunney
authors.forename: P J
authors.initials: PJ
authors.lastname: Tummino
authors.forename: D
authors.initials: D
authors.lastname: Ferguson
authors.forename: D
authors.initials: D
authors.lastname: Hupe
authors.forename: C
authors.initials: C
authors.lastname: Nouhan
authors.forename: S J
authors.initials: SJ
authors.lastname: Gracheck
authors.forename: J M
authors.initials: JM
authors.lastname: Saunders
authors.forename: S
authors.initials: S
authors.lastname: VanderRoest
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D051379:Mice; D011753:Pyrones / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D011753:Pyrones