Effects on intraocular pressure and aqueous flow of various dose regimens of latanoprost in human eyes.
OBJECTIVE
To examine if different dose regimens of latanoprost cause a difference in daytime intraocular pressure (IOP) in normal eyes and if such changes could be attributed to an increase in aqueous flow.


METHODS
In a randomised, open, cross-over study latanoprost 50 microg/ml was instilled in one eye of 18 volunteers. Three dose regimens (one/three drops once daily or one drop twice daily) were evaluated. IOP was measured at the end of each 14-day treatment period. Aqueous flow and endothelial permeability were assessed by fluorophotometry.


RESULTS
All dose regimens reduced IOP significantly (p < 0.001). Once daily applications reduced IOP more than twice daily (p < 0.01). No statistically significant difference in aqueous flow was detected between different treatments. One drop daily increased aqueous flow compared with control eyes (p < 0.05). A similar, but not statistically significant tendency was present with the other regimens. Corneal endothelial permeability was not affected.


CONCLUSIONS
Once daily applications of latanoprost reduce IOP more effectively than twice daily in normal subjects. This cannot be explained by an increase in aqueous flow.
Lindén
C
C
Department of Ophthalmology, Umeå University, Sweden.
Alm
A
A
D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D004728:Endothelium, Corneal / Q000378:metabolism; D005260:Female; D015590:Fluorophotometry; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D010539:Permeability; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology
D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost