Clinical, morphologic, and biochemical characteristics of Chediak-Higashi syndrome in fifty-six Japanese black cattle.
OBJECTIVE
To characterize Chediak-Higashi syndrome (C-HS) in Japanese Black cattle.


METHODS
56 of 200 cattle with a bleeding disorder and giant granules in leukocytes.


METHODS
Clinical observation, CBC, hemostatic screening test, platelet aggregometry, electron microscopy, platelet constituent analysis, and ophthalmoscopic examination were done.


RESULTS
Affected Japanese Black cattle had increased bleeding tendency and abnormal granules in their leukocytes. Susceptibility to infection was not increased. Cutaneous albinism was evident in 6 new-born calves, but not in most affected cattle. In all affected cattle, the tapetal fundus was pale and the nontapetal fundus was almost devoid of pigment. By electron microscopy, a remarkable decrease in the number of dense granules in platelets was observed. Functionally, collagen-induced platelet aggregation was markedly reduced.


CONCLUSIONS
This bleeding disorder was diagnosed as C-HS. With regard to susceptibility to infection, albinism, and mortality, clinical manifestations of C-HS in Japanese Black cattle were moderate, compared with C-HS in human beings and Hereford cattle.


CONCLUSIONS
Because an autosomal recessive mode of inheritance was documented and recessive homozygotes could be easily detected, C-HS in Japanese Black cattle can be controlled.
Ogawa
H
H
Department of Veterinary Surgery, Faculty of Agriculture, Miyazaki University, Japan.
Tu
C H
CH
Kagamizono
H
H
Soki
K
K
Inoue
Y
Y
Akatsuka
H
H
Nagata
S
S
Wada
T
T
Ikeya
M
M
Makimura
S
S
Uchida
K
K
Yamaguchi
R
R
Otsuka
H
H
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D002609:Chediak-Higashi Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary*; D003094:Collagen / Q000494:pharmacology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D005654:Fundus Oculi; D006487:Hemostasis; D006720:Homozygote; D007564:Japan / Q000453:epidemiology; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D008854:Microscopy, Electron / Q000379:methods / Q000662:veterinary; D009887:Ophthalmoscopy / Q000379:methods / Q000662:veterinary; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects / Q000662:veterinary
D000244:Adenosine Diphosphate; D003094:Collagen