[Prevalence of clinical manifestations of allergic reactions in HIV infection. Cross sectional study of 115 subjects].
A cross sectional survey was set up to study the relation between the prevalence of allergic-type reactions during HIV infection course. For each patient, a standardized interview about recent allergic-type manifestations (RATM), skin prick-tests to six common airborne allergens, IgE serum level were done. Among the 115 included patients, the mean CD4 lymphocyte count (CD4) was 214.7/mm3 (range: 0-1328/mm3). RATM were found in 8.8% of patients with CD4 < 50, in 30% of patients with CD4 between 51 and 200, in 36% of patients with CD4 between 201 and 350 and in 11.5% of patients with CD4 < 350 (p = 0.03). The risk of presenting RATM was 4.8 times (95% confidence interval = 1.7-13.5) higher in patients with CD4 between 51 and 350 than in other patients (p = 0.003). The proportion of positive prick-tests did not significantly vary according to the level of CD4. The increased frequency of RATM in patients with CD4 between 51 and 350/mm3 could be due to an allergic predisposition acquired during the course of HIV infection. The mechanisms explaining the reduced frequency of allergic manifestations when immunodeficiency is profound (CD4 < 50/mm3) remain to be explained.
Rancinan
C
C
Inserm U330, université de Bordeaux II, France.
Morlat
P
P
Chêne
G
G
Saillour
F
F
Guez
S
S
Lacoste
D
D
Bernard
N
N
Doutre
M S
MS
Sériès
C
C
Aubertin
J
J
Beylot
J
J
Salamon
R
R
D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000276:immunology*; D016867:Immunocompromised Host; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D015995:Prevalence; D012882:Skin Tests; D011795:Surveys and Questionnaires; D013997:Time Factors
D007073:Immunoglobulin E