Skin necrosis secondary to low-molecular weight heparin in a patient with antiphospholipid antibody syndrome.
Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites. It occasionally accompanies the heparin-associated thrombocytopenia and thrombosis syndrome. We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.
Gibson
G E
GE
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Gibson
L E
LE
Drage
L A
LA
Garrett
C R
CR
Gertz
M A
MA
D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000628:therapy; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009336:Necrosis; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000150:complications / Q000188:drug therapy
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight