Time-dependent interactions between iboga agents and cocaine.
The purpose of this study was to clarify the effects of iboga agents on cocaine-induced hyperactivity. Both inhibition and enhancement of cocaine-induced activity by ibogaine have been reported. In the present study, rats were treated with either ibogaine (40 mg/kg, i.p.), noribogaine (40 mg/kg, i.p.), 18-methoxycoronaridine (40 mg/kg, i.p.), or saline, 1 or 19 h prior to the administration of cocaine (20 mg/kg, i.p.) or saline. Motor activity was monitored thereafter for 3 h. All three iboga agents had acute inhibitory effects and delayed potentiating effects on cocaine-induced hyperactivity. These time-dependent effects, which could not be attributed to the motor activity induced by the iboga agents alone, account for divergent results reported in the literature.
Maisonneuve
I M
IM
Department of Pharmacology and Neuroscience, Albany Medical College, NY 12208, USA. maison@ccgateway.amc.edu
Visker
K E
KE
Mann
G L
GL
Bandarage
U K
UK
Kuehne
M E
ME
Glick
S D
SD
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D007050:Ibogaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D009294:Narcotics; D007050:Ibogaine; C094385:noribogaine; D003042:Cocaine; C103345:18-methoxycoronaridine