title: Dialysis membrane adsorption during CRRT.
abstract: Experimental and clinical studies have suggested that dialysis membrane biocompatibility may influence the morbidity and mortality of patients with acute renal failure. Complement activation by dialysis membranes may also prolong the recovery from acute renal failure. In this article, we review the concept of dialysis membrane adsorption, with particular attention to adsorption/inhibition of factor D, a highly specific serine protease of the alternative pathway of complement. The adsorptive properties of some dialysis membranes may be useful during continuous renal replacement therapies (CRRT) in critically ill patients.
authors.affiliation: Renal Unit, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Swinford
authors.forename: S
authors.initials: S
authors.lastname: Baid
authors.forename: M
authors.initials: M
authors.lastname: Pascual
mesh_terms: D058186:Acute Kidney Injury / Q000276:immunology / Q000628:therapy*; D001672:Biocompatible Materials; D011416:Complement Factor D / Q000378:metabolism; D006440:Hemofiltration; D006801:Humans; D008567:Membranes, Artificial; D006435:Renal Dialysis
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; C493488:CFD protein, human; D011416:Complement Factor D