Chromosomal analysis to assess radiation dose.
This brief account of dosimetry based on cytogenetic assays reviews the sensitivity of the method and the speed with which a dose estimate can be obtained. The usefulness of chromosome studies to physicians is also discussed. Medical uses include confirming triage category for highly irradiated subjects and providing evidence for nonuniform exposure or other reasons for the presence of surviving functional stem cells. Such information can assist in medical management decisions, especially regarding transplantation of marrow or stem cells and treatment with growth factors. For subjects exposed to zero or low doses, cytogenetic studies can provide useful information for assisting physicians in counseling.
Lloyd
D C
DC
National Radiological Protection Board, Didcot, Oxon, UK.
D016026:Bone Marrow Transplantation; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000528:radiation effects*; D016001:Confidence Intervals; D004781:Environmental Exposure; D005720:Gamma Rays; D006133:Growth Substances / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D011210:Power Plants; D011832:Radiation Injuries / Q000628:therapy; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000379:methods*; D012680:Sensitivity and Specificity; D014455:Ukraine
D006133:Growth Substances