title: Intracytoplasmic sperm injection pregnancy with fetal trisomy 9p resulting from a balanced paternal translocation.
abstract: Infertile men who carry a chromosomal translocation can be successfully treated with intracytoplasmic sperm injection (ICSI). However, such treatment carries a risk that a pregnancy with an abnormal karyotype will be induced. While in all previously published cases the outcome was favourable, we here report the first instance of a parental reciprocal translocation leading to a chromosomally unbalanced ICSI pregnancy. The fetus, one of a pair of dizygotic twins, was found to have trisomy for the short arm of chromosome 9. The parents opted for selective abortion of the affected twin.
authors.affiliation: Institute of Human Genetics, Münster, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Meschede
authors.forename: F
authors.initials: F
authors.lastname: Louwen
authors.forename: B
authors.initials: B
authors.lastname: Eiben
authors.forename: J
authors.initials: J
authors.lastname: Horst
mesh_terms: D000649:Amniocentesis; D002899:Chromosomes, Human, Pair 9; D017218:Cordocentesis; D003593:Cytoplasm; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics / Q000628:therapy*; D007621:Karyotyping; D008297:Male; D008845:Microinjections; D011247:Pregnancy; D018607:Pregnancy Reduction, Multifetal; D014178:Translocation, Genetic; D014314:Trisomy