title: A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus.
abstract: A herpesvirus that is related to but distinct from the Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8) was isolated from rhesus monkeys. The sequence of 10.6 kbp from virion DNA revealed the presence of an interleukin-6 homolog similar to what is present in KSHV and a closer relatedness of the DNA polymerase and glycoprotein B reading frames to those of KSHV than to those of any other herpesvirus. This rhesus monkey herpesvirus replicated lytically and to high titers in cultured rhesus monkey fibroblasts. Antibody testing revealed a high prevalence for at least 10 years in our rhesus monkey colony and a high prevalence in two other colonies that were tested. Thus, rhesus monkeys naturally harbor a virus related to KSHV, which we have called RRV, for rhesus monkey rhadinovirus.
authors.affiliation: New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Desrosiers
authors.forename: V G
authors.initials: VG
authors.lastname: Sasseville
authors.forename: S C
authors.initials: SC
authors.lastname: Czajak
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: K G
authors.initials: KG
authors.lastname: Mansfield
authors.forename: A
authors.initials: A
authors.lastname: Kaur
authors.forename: R P
authors.initials: RP
authors.lastname: Johnson
authors.forename: A A
authors.initials: AA
authors.lastname: Lackner
authors.forename: J U
authors.initials: JU
authors.lastname: Jung
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001483:Base Sequence; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D004279:DNA, Viral; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D006023:Glycoproteins / Q000235:genetics; D006564:Herpesviridae; D006566:Herpesviridae Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D019288:Herpesvirus 8, Human; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D008253:Macaca mulatta / Q000821:virology*; D008969:Molecular Sequence Data; D018144:Rhadinovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D012514:Sarcoma, Kaposi / Q000821:virology*; D014412:Tumor Virus Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D006023:Glycoproteins; D015850:Interleukin-6; D014764:Viral Proteins; D004259:DNA-Directed DNA Polymerase