title: The accuracy of peripheral skeletal assessment at the radius in estimating femoral bone density as measured by dual-energy X-ray absorptiometry: a comparative study of single-photon absorptiometry and computed tomography.
abstract: OBJECTIVE
  One of the latest developments in bone densitometry is peripheral quantitative computed tomography (pQCT), a method which allows the separate determination of cortical and trabecular bone mineral density (BMD) in the peripheral skeleton. This study was designed to compare the relative abilities of single-photon absorptiometry (SPA) and pQCT to reflect BMD of the proximal femur as measured by dual-energy X-ray absorptiometry (DXA), an established predictor of osteoporotic hip fracture risk.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  A well-defined community-based sample of 129 skeletally healthy women aged 70-87 years.
  
  
  METHODS
  Radial BMD by SPA and pQCT and femoral BMD by DXA. Univariate and multivariate regression analyses were performed relating the DXA measurements at the femoral neck and the trochanteric region with the values of SPA and pQCT.
  
  
  RESULTS
  Approximately 38% of the variance in femoral neck BMD could be explained by BMD of the midradius assessed by SPA, in contrast to only 18-27% by pQCT. At the trochanter, 32% of BMD could be predicted by SPA as compared to 19-26% by pQCT. Moreover, according to multiple regression, prediction of femoral BMD by SPA was not enhanced by performing pQCT.
  
  
  CONCLUSIONS
  Radial pQCT has little value as a screening tool to identify elderly women with low femoral BMD. Additional research is needed to determine whether or not pQCT will enhance fracture prediction beyond that obtainable from a density measurement by SPA.
authors.affiliation: Department of Internal Medicine, Katholieke Universiteit Leuven, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Boonen
authors.forename: X
authors.initials: X
authors.lastname: Cheng
authors.forename: P H
authors.initials: PH
authors.lastname: Nicholson
authors.forename: G
authors.initials: G
authors.lastname: Verbeke
authors.forename: P
authors.initials: P
authors.lastname: Broos
authors.forename: J
authors.initials: J
authors.lastname: Dequeker
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D003430:Cross-Sectional Studies; D005260:Female; D005269:Femur / Q000502:physiology*; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D011884:Radius / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed