Effect of ocular perfusion pressure on retinal function in the rabbit.
The electroretinogram (ERG) vs perfusion pressure relation was studied in anesthetized rabbits during mechanically induced changes in mean arterial pressure (MAP). After 1 hr of dark adaptation, ERGs were obtained at perfusion pressures from 10 to 95 mmHg with each pressure held for 30-60 sec, and at three levels from 15 to 75 mmHg with each pressure held for 5 min. The slopes of the b-wave amplitude vs perfusion pressure data were not significantly different from zero during either the brief or longer manipulations of perfusion pressure. However, the b-wave was nearly extinguished 5 min after death. The results indicate that the rabbit ERG is maintained over a wide range of perfusion pressure.
Harrison
J M
JM
Department of Ophthalmology, University of Texas Health Science Center, San Antonio 78284, USA. harrisonj@uthscsa.edu
Kiel
J W
JW
Smith
S
S
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002829:Choroid / Q000098:blood supply; D003623:Dark Adaptation / Q000502:physiology; D004596:Electroretinography; D005123:Eye / Q000098:blood supply*; D007429:Intraocular Pressure / Q000502:physiology; D011817:Rabbits; D012039:Regional Blood Flow; D012160:Retina / Q000502:physiology