title: The treatment and prevention of obesity: a systematic review of the literature.
abstract: OBJECTIVE
  To determine the effectiveness of interventions designed to prevent and treat obesity, and maintain weight loss.
  
  
  METHODS
  A systematic review of randomised controlled trials.
  
  
  METHODS
  Overweight and obese adults and children.
  
  
  METHODS
  Post-intervention changes in weight, fat content and fat distribution, measured relative to baseline.
  
  
  RESULTS
  For obese children, family therapy and lifestyle modification appear to be effective in prevention and treatment, respectively. The effectiveness of interventions to prevent and treat obesity in adults remains unclear, although behavioural therapy and multicomponent strategies may be useful. Continued therapist contact appears to be useful for maintaining weight loss. Pharmacological interventions appear to be effective for up to 9 months, after which regain occurs. Surgery appears to be effective for the morbidly obese and gastric bypass is more effective than gastroplasty. In general, the methodological quality of studies was poor.
  
  
  CONCLUSIONS
  Due to problems with methodological quality, it is recommended that research findings indicative of promising interventions are replicated.
authors.affiliation: NHS Centre for Reviews and Dissemination, University of York, Heslington.
authors.forename: A M
authors.initials: AM
authors.lastname: Glenny
authors.forename: S
authors.initials: S
authors.lastname: O'Meara
authors.forename: A
authors.initials: A
authors.lastname: Melville
authors.forename: T A
authors.initials: TA
authors.lastname: Sheldon
authors.forename: C
authors.initials: C
authors.lastname: Wilson
mesh_terms: D000293:Adolescent; D000328:Adult; D001067:Appetite Depressants / Q000627:therapeutic use; D001521:Behavior Therapy; D002648:Child; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D015444:Exercise; D005196:Family Therapy; D005260:Female; D015390:Gastric Bypass; D015391:Gastroplasty; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000517:prevention & control* / Q000628:therapy*; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D001067:Appetite Depressants