Transplantation biology.
A variety of hemopoietic tissues are now being used as a source of stem cells for clinical transplantation. These tissues all have different biological properties, which are not yet fully understood, as well as particular clinical applications, advantages, and disadvantages. The development of protocols for the manipulation of stem cells prior to infusion into patients will, it is hoped, lead to the further improvement of stem cell replacement therapy including the use of stem cells as vectors for expressing transduced genes. Success in these efforts will depend on an improved understanding of the biological principles underlying hemopoietic stem cell transplantation.
Gordon
M Y
MY
Leukaemia Research Fund Centre, Institute of Cancer Research, London, UK.
D005312:Fetal Blood / Q000166:cytology; D015316:Genetic Therapy; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D010920:Placenta / Q000098:blood supply
D016298:Hematopoietic Cell Growth Factors