title: [Central nervous system lesions in the early stages of HIV infection].
abstract: Early HIV-1 invasion of the central nervous system has been demonstrated by many cerebrospinal fluid studies; however, most HIV-1 carriers remain neurologically unimpaired during the so-called "asymptomatic" period lasting from seroconversion to symptomatic AIDS. Therefore, very few neuropathological studies have been conducted in the early pre-AIDS stages, and the natural history of central nervous system changes in HIV-1 infection remains poorly understood. Examination of brains of asymptomatic HIV-1 positive individuals who died accidentally and of rare cases with acute fatal encephalopathy revealing HIV infection, and comparison with experimental simian immunodeficiency virus and feline immunodeficiency virus infections suggest that, invasion of the CNS by HIV-1 occurs at the time of primary infection and induces an immunological process in the central nervous system. This includes an inflammatory T-cell reaction with vasculitis and leptomeningitis, and immune activation of brain parenchyma with increased number of microglial cells, upregulation of major histocompatibility complex class II antigens and local production of cytokines. Myelin pallor and gliosis of the white matter are usually found and are likely to be the consequence of opening of the blood-brain barrier due to vasculitis; direct damage to oligodendrocytes by cytokines may also be involved. These white matter changes may explain, at least partly, the early cerebral atrophy observed, by magnetic resonance imaging, in asymptomatic HIV-1 carriers. In contrast, cortical damage seems to be a late event in the course of HIV-1 infection. There is no significant neuronal loss at the early stages of the disease, no accompanying increase in glial fibrillary acid protein staining in the cortex, and only exceptional neuronal apoptosis. Although HIV-1 proviral DNA may be demonstrated in a number of brains, viral replication remains very low during the asymptomatic stage of HIV-1 infection. This makes it likely that, although opening of the blood brain barrier may facilitate viral entry into the brain, specific immune responses including both neutralising antibodies and cytotoxic T-lymphocytes, continuously inhibit viral replication at this stage.
authors.affiliation: Laboratoire d'Anatomie Pathologique et de Médecine Légale, Hôpital Raymond-Poincaré, Faculté de Médecine Paris-Ouest, Garches, France.
authors.forename: L
authors.initials: L
authors.lastname: Wingertsmann
authors.forename: F
authors.initials: F
authors.lastname: Chrétien
authors.forename: F J
authors.initials: FJ
authors.lastname: Authier
authors.forename: F
authors.initials: F
authors.lastname: Paraire
authors.forename: M
authors.initials: M
authors.lastname: Durigon
authors.forename: F
authors.initials: F
authors.lastname: Gray
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology*; D000818:Animals; D002415:Cats; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology*; D015658:HIV Infections / Q000276:immunology / Q000473:pathology*; D006679:HIV Seropositivity / Q000276:immunology / Q000473:pathology*; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D014779:Virus Replication