[The evaluation of the effect of venodilatation in 2 different systems of transdermal nitroglycerin release].
The aim of our study was to compare the activity of two different nitroglycerin controlled release systems (active matrix versus polyptychial matrix) on venous lower limbs circulation evaluated with strain-gauge plethysmography. Ten patients with stable coronary heart disease (M 5, F 5, mean age 65.1 +/- 4.6) were recruited and randomized to receive transdermal placebo and 5 or 10 mg of nitroglycerin carried by polyptychial or active matrix in a sequential and variable order. Five transdermal delivery systems were used with different content: placebo, nitroglycerin 5 or 10 mg on two different matrices (active matrix or polyptychial matrix). Venous strain-gauge plethysmography was performed in basal conditions and after 30, 60, 90, 120, 180, 240, 480, 1440 minutes, to evaluate the following parameters: maximal venous incremental volume at 40 and 60 mmHg (MVIV40 and MVIV60); time of maximal venous incremental volume at 60 mmHg (tMVIV60); maximal volume of outflow (MVO); time of maximal volume of outflow (tMVO); index of venous distensibility (dV/dP); index of venous tone (dP/dP); venous pressure (PV). Statistical data analysis was performed by one-way A.NO.VA and two-tailed Student's t test. The results of our study have shown that both transdermal systems, active and polyptychial matrix, are able to induce a venodilatation, but venodilatation induced by active matrix carried transdermal nitroglycerin along 24 hours is more stable and higher than that induced by polyptychial matrix carried transdermal nitroglycerin.
Cappelli
R
R
Istituto di Semeiotica Medica e Geriatria, Università, Siena.
Arrigucci
S
S
Vedovini
G
G
Bicchi
M
M
Forconi
S
S
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016503:Drug Delivery Systems / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology; D005996:Nitroglycerin / Q000008:administration & dosage*; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D005996:Nitroglycerin