Signaling mechanistics: aluminum fluoride for molecule of the year.
Recent three-dimensional structures of phosphoryl transfer enzymes in their aluminum fluoride bound state and corresponding biochemical data have shown how diverse biological problems can be investigated using this small inorganic molecule.
Wittinghofer
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Max-Planck-Institut für Molekulare Physiologie, Rheinlanddamm 201, 44139 Dortmund, Germany.
D017607:Aluminum Compounds / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D005459:Fluorides / Q000737:chemistry / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D015335:Molecular Probes / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D017607:Aluminum Compounds; D015335:Molecular Probes; D019204:GTP-Binding Proteins; D005459:Fluorides; C032311:aluminum fluoride