The association between Apo E genotype and depressive symptoms in elderly African-American subjects.
In this study of 138 elderly subjects (112 without and 26 with dementia) obtained from a community sample of elderly African-American subjects, there were no significant differences in mean Geriatric Depression Scale scores by Apo E epsilon 4 status for dementia or nondementia subjects. Three subjects received a diagnosis of major depressive disorder. None of these subjects were Apo E epsilon 4-positive. These results do not support an association between depressive symptoms and Apo E allele status in this elderly African-American population.
Class
C A
CA
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202, USA.
Unverzagt
F W
FW
Gao
S
S
Sahota
A
A
Hall
K S
KS
Hendrie
H C
HC
D000368:Aged; D000375:Aging; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology*; D005838:Genotype; D006801:Humans; D001741:Black or African American
D001057:Apolipoproteins E