title: The effects of imidazoacridinones, new antineoplastic agents, on the human erythrocyte membrane.
abstract: In the present study, the interactions of imidazoacridinones, C-1311 and C-1371 with human erythrocyte membranes were examined by electron spin resonance spectroscopy (ESR). It was observed that both compounds C-1311 and C-1371 preferentially bind to proteins producing the conformational changes of erythrocyte membrane skeletal proteins.
authors.affiliation: Department of Thermobiology, University of Lódź, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Jóźwiak
authors.forename: M
authors.initials: M
authors.lastname: Pacholska
authors.forename: A
authors.initials: A
authors.lastname: Szwarocka
mesh_terms: D000609:Aminoacridines / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008560:Membrane Fluidity / Q000187:drug effects; D011487:Protein Conformation / Q000187:drug effects; D013696:Temperature
chemical_list: D000609:Aminoacridines; D000970:Antineoplastic Agents; C110046:C 1371; D003598:Cytoskeletal Proteins; C098965:C 1311