title: Protective immunity induced by vaccination with two Haemonchus contortus excretory secretory proteins in sheep.
abstract: Two excretory secretory (ES) antigens of adult Haemonchus contortus with molecular weights of 15 and 24 kDa, respectively, were evaluated as protective immunogen against haemonchosis. Sheep were vaccinated three times and subsequently challenged with 20,000 infective larvae. Vaccination induced significant reduction (> 70%) in mean faecal egg counts and abomasal worm burden compared to the non-vaccinated control group or adjuvant control group. Vaccination induced ES-specific antibodies and stimulated infiltration of mast cells in the abomasal tissue.
authors.affiliation: Utrecht University, Department of Parasitology & Tropical Veterinary Medicine, The Netherlands.
authors.forename: H D
authors.initials: HD
authors.lastname: Schallig
authors.forename: M A
authors.initials: MA
authors.lastname: van Leeuwen
authors.forename: A W
authors.initials: AW
authors.lastname: Cornelissen
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D006189:Haemonchus / Q000276:immunology*; D015801:Helminth Proteins / Q000276:immunology*; D007109:Immunity; D012756:Sheep / Q000469:parasitology*; D014611:Vaccination
chemical_list: D000947:Antigens, Helminth; D015801:Helminth Proteins