[Identification of the origin of 7q+ marker chromosome in a mental retard patient].
The present chromosome-specific and chromosome-band-specific probe pools constructed by the technique of human chromosome microdissection and PCR were taken as painting probes. Using the forward chromosome painting and chromosome screening method, we had identified a chromosome additional fragment of a 7 q+ marker chromosome in a patient originated from 3 q 26-->3 qter, and ascertained the patient's karyotype was 46, XX, -7, + der (7) t (7;3) (7 pter-->7 q 32::3 q 26-->3 qter). Applying this strategy, we can identify the origin of marker chromosomes fastly and effectively.
Fu
J J
JJ
Hunan Medical University, State Key Laboratory of Medical Genetics, Changsha.
Xia
J H
JH
Long
Z G
ZG
Yang
Y
Y
Pan
Q
Q
Liao
X D
XD
Xia
X
X
Chen
S X
SX
D002648:Child; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D014178:Translocation, Genetic