The effects of haloperidol on visual search, eye movements and psychomotor performance.
The effects of single doses of haloperidol (2, 4 and 6 mg) were compared with lorazepam 2.5 mg and placebo in 15 healthy subjects. Visual search strategy was measured, along with a range of psychomotor and eye movement tests. Patients with Parkinson's disease have been shown to exhibit a shift from parallel to serial processing in visual search, but we demonstrated that this does not occur following administration of either haloperidol or lorazepam. Haloperidol was detected by visual analogue rating scales and peak saccadic velocity, the latter being the more sensitive measure. Haloperidol had no statistically significant effect on smooth pursuit position error, velocity error or saccadic intrusions. Digit symbol substitution performance was clearly diminished by haloperidol, but there was no effect on the continuous attention test. Lorazepam decreased performance in all tests apart from saccadic latency.
Lynch
G
G
Holywell Hospital, Antrim, UK.
King
D J
DJ
Green
J F
JF
Byth
W
W
Wilson-Davis
K
K
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects; D018592:Cross-Over Studies; D018492:Dopamine Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D005133:Eye Movements / Q000187:drug effects*; D018757:GABA Modulators / Q000494:pharmacology; D006220:Haloperidol / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D011698:Pursuit, Smooth / Q000187:drug effects; D012438:Saccades / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects*
D018492:Dopamine Antagonists; D018757:GABA Modulators; D006220:Haloperidol; D008140:Lorazepam