title: MR findings in hereditary isolated growth hormone deficiency.
abstract: OBJECTIVE
  To describe the MR characteristics by which patients with hereditary isolated growth hormone deficiency (GHD) can be distinguished from patients with other types of GHD.
  
  
  METHODS
  A total of 51 patients with GHD were examined prospectively with MR imaging. On the basis of familial occurrence of GHD and genetic analysis, 10 patients met the criteria for hereditary deficiency. In each case, the height of the pituitary gland, the presence and location of the posterior neurohypophysis, and the completeness of the stalk were recorded. The findings in the hereditary group were compared with those in the rest of the patients.
  
  
  RESULTS
  In all 10 patients with hereditary GHD, the adenohypophysis, the neurohypophysis, and the stalk were normal. Of the other 41 patients, the height of the gland was normal in three (7%), the neurohypophysis was abnormal in all, and the stalk was truncated in all but two patients (95%).
  
  
  CONCLUSIONS
  The subgroup of patients with hereditary GHD exhibited an anatomically normal pituitary-hypothalamic region. This is in contrast to the majority of patients with idiopathic GHD. MR imaging can contribute to the classification of patients with GHD.
authors.affiliation: Department of Imaging, Schneider Children's Medical Center of Israel, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University.
authors.forename: L
authors.initials: L
authors.lastname: Kornreich
authors.forename: G
authors.initials: G
authors.lastname: Horev
authors.forename: L
authors.initials: L
authors.lastname: Lazar
authors.forename: Z
authors.initials: Z
authors.lastname: Josefsberg
authors.forename: A
authors.initials: A
authors.lastname: Pertzelan
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004393:Dwarfism, Pituitary / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007031:Hypothalamus / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000473:pathology; D011446:Prospective Studies
chemical_list: D019382:Human Growth Hormone