title: Spinal cord compression in prostate cancer: treatment outcome and prognostic factors.
abstract: OBJECTIVE
  Spinal cord compression (SCC) is an important complication of metastatic prostate cancer. We have analysed patients treated at the Royal Marsden Hospital to assess treatment outcome and prognostic factors in this patients group.
  
  
  METHODS
  We performed retrospective analysis of 69 patients with spinal cord compression and prostate cancer treated at the Royal Marsden Hospital.
  
  
  RESULTS
  At presentation 40 (58%) patients were non-ambulant and 52% were catheterised. Diagnosis was established by myelography in 42% and magnetic resonance imaging (MRI) in 47% of patients. MRI detected significantly more patients with multiple sites of compression (51 versus 7%, P < 0.001). SCC was present at the initial diagnosis of prostatic cancer in 13 patients and 17 patients had received no hormone treatment prior to diagnosis. Following treatment 36 (52%) patients had a functional improvement of motor power with 25/40 (63%) non-ambulant patients becoming ambulant. Seventy-seven percent of patients who had eventual improvement had some improvement in power within 7 days. On multivariate analysis a single level of compression, no previous hormone therapy and a young age (<65 years) predicted for better outcome. When these factors were included an increased radiation dose (>30 Gy) or the addition of surgery did not improve the functional outcome. Following initial recovery; there was a 45% risk of developing a further episode of cord compression at the same or new site by 2 years with a median time to progression of 236 days (range 47-1215 days). The median survival was 115 days (range 5-2016 days) with 25% of patients surviving for 2 years. Patients with no prior hormone therapy had a median survival of 627 days (range 46-1516 days). Other predictors of improved survival on multivariate analysis were a single site of compression and a haemoglobin over 12 g.
  
  
  CONCLUSIONS
  Treatment of SCC in prostate cancer results in improved motor function in the majority of patients. Long-term survival is possible, especially in good performance status patients with no prior hormone treatment. Survivors remain at high risk of subsequent neurological relapse. An early improvement in motor power is a strong predictor of subsequent functional improvement. MRI detects additional sites of asymptomatic SCC which makes it the investigation of choice.
authors.affiliation: Department of Academic Radiotherapy and Oncology, Royal Marsden NHS Trust and Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Huddart
authors.forename: B
authors.initials: B
authors.lastname: Rajan
authors.forename: M
authors.initials: M
authors.lastname: Law
authors.forename: L
authors.initials: L
authors.lastname: Meyer
authors.forename: D P
authors.initials: DP
authors.lastname: Dearnaley
mesh_terms: D000368:Aged; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009192:Myelography; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000150:complications*; D012189:Retrospective Studies; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000209:etiology* / Q000532:radiotherapy*; D016896:Treatment Outcome