Human endometrial cancers contain follicle-stimulating hormone receptors: a preliminary study.
In order to investigate whether human endometrial cancers contain follicle-stimulating hormone (FSH) receptors, cancer fragments were collected at hysterectomy in six post-menopausal women affected by histologically confirmed endometrial malignancy. Cryostat sections were prepared for in situ binding investigation. Positive endometrial glandular cells were registered in all cancers; 125I-FSH binding sites seemed to increase with the increasing tumor grade. Our data demonstrated for the first time that human endometrial cancers contain specific FSH receptors.
Noci
I
I
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Florence, Italy.
Borri
P
P
Taddei
G L
GL
Moncini
D
D
Barni
T
T
Vannelli
G B
GB
D000368:Aged; D001345:Autoradiography; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000601:surgery; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007044:Hysterectomy; D007457:Iodine Radioisotopes; D008875:Middle Aged; D017698:Postmenopause; D011962:Receptors, FSH / Q000032:analysis*
D007457:Iodine Radioisotopes; D011962:Receptors, FSH; D005640:Follicle Stimulating Hormone