title: Memory and intellectual deficits do not decline with age in schizophrenia.
abstract: Cognitive deficits in schizophrenia are reported to be more consistent with a static encephalopathy than a dementing disorder. This study investigates memory and intellectual decline in 62 chronic schizophrenic subjects using the Wechsler Adult Intelligence Scale-Revised (WAIS-R), the Rivermead Behavioural Memory Test and the National Adult Reading Test (NART) in a cross-sectional study using five age cohorts (18-29, 30-39, 40-49, 50-59 and 60-69 years of age) and then by two cohorts (young: 18-39; older: 40-69). A second method of investigating intellectual decline was implemented by estimating the discrepancy score between WAIS-R (current IQ) and NART (premorbid IQ) for each subject. No significant differences were found in WAIS-R Full Scale. Verbal and Performance IQ and memory functioning across the five age cohorts (and when using two age groups). A significant difference in test scores was found using the Picture Completion and Digit Symbol subtests of the WAIS-R. The differences were not related to age or duration of illness. No significant difference in scores were evident in the remaining WAIS-R subtests. These results support previous findings that schizophrenia is more consistent with a static encephalopathy than a dementing disorder and that intellectual and memory function does not markedly decline with age.
authors.affiliation: Sub-Department of Clinical Health Psychology, University College London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Mockler
authors.forename: J
authors.initials: J
authors.lastname: Riordan
authors.forename: T
authors.initials: T
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000503:physiopathology*; D015988:Cohort Effect; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011932:Reading; D012044:Regression Analysis; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014888:Wechsler Scales