title: Novel carbocyclic nucleosides containing a cyclopentyl ring. Adenosine and uridine analogues.
abstract: cis-3-Aminomethylcyclopentylmethanol (4) was used as a precursor in the synthesis of carbocyclic nucleosides containing adenine, hypoxanthine, 8-azahypoxanthine, uracil, and 5-iodouracil bases. None of these compounds had appreciable activity against eighteen viruses in the concentration ranges tested. Two of them showed a weak cytostatic activity against three tumor lines.
authors.affiliation: Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Balo
authors.forename: F
authors.initials: F
authors.lastname: Fernández
authors.forename: E
authors.initials: E
authors.lastname: Lens
authors.forename: C
authors.initials: C
authors.lastname: López
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De CLercq
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014529:Uridine / Q000031:analogs & derivatives*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D000241:Adenosine; D014529:Uridine