[Studies on the metabolites of tetramethylpyrazine in human urine].
Tetramethylpyrazine (TMP), an active ingredient in Chuanxiong (Ligusticum Wallich Franch), a traditional Chinese herb, has been widely used especially in the treatment of patients with cerebral ischemic diseases in China. TMP was reported to have a short half-life time because of its rapid metabolism in the liver. In this paper we studied its metabolites in human urine with GC/MS after oral administration of TMP. Three metabolites were found in the water soluble acidic fraction of the urine and the main metabolite was identified to be 3,.5,6-trimethylpyrazinecarboxylic acid.
Ye
Y
Y
PUMC Hospital, CAMS, Beijing.
Wang
S
S
Jiang
J
J
D000328:Adult; D006801:Humans; D008297:Male; D011719:Pyrazines / Q000378:metabolism* / Q000652:urine*; D014665:Vasodilator Agents / Q000652:urine*
C109800:3,5,6-trimethylpyrazinecarboxylic acid; D011719:Pyrazines; D014665:Vasodilator Agents; C017953:tetramethylpyrazine