[Serum adrenaline and noradrenaline levels in cirrhosis patients with portal hypertension].
High Pressure Liquid chromatography was used to measure serum adrenaline (E) and noradrenaline (NE) concentrations in 38 portal hypertensive patients, 28 idiopathic hypertensive patients, and 34 controls, respectively. It was found that peripheral E in portal hypertensive patients and controls was 57.5 +/- 37.4 pg/ml and 23.5 +/- 11.2 pg/ml respectively (P < 0.01), and peripheral NE was 451.1 +/- 381.2 pg/ml and 183.0 +/- 83.3 pg/ml (P < 0.01). Compared with controls, peripheral E and NE in idiopathic hypertensive patients were also significantly increased (54.9 +/- 39.9 pg/ml vs. 23.6 +/- 11.2 pg/ml, P < 0.01, and 524.3 +/- 219.9 pg/ml vs. 183.0 +/- 83.3 pg/ml, P < 0.01). E and NE in superior vena cava (SVC), portal vein, and peripheral artery in portal hypertensive patients were also increased, but only the elevation of E in SVC was significant (207.2 +/- 55.4 pg/ml vs. 83.7 +/- 46.7 pg/ml, P < 0.05). Our results reveal significant metabolic disorders of E and NE in portal hypertensive patients, which may play an important role in the pathogenesis of portal hypertension.
Zhu
J
J
Department of Surgery, People's Hospital, Beijing Medical University.
Du
R
R
Leng
X
X
D000328:Adult; D000368:Aged; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006509:Hepatitis B; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*
D009638:Norepinephrine; D004837:Epinephrine