Synaptic relationships between corticocuneate terminals and glycine-immunoreactive neurons in the rat cuneate nucleus.
The present study describes the ultrastructural synaptic relationships between corticocuneate terminals (CCTs) and glycine-immunoreactive (glycine-IR) neurons in the cuneate nucleus of rats using anterograde tract-tracing of wheatgerm agglutinin conjugated with horseradish peroxidase (WGA-HRP) and anti-glycine immunoperoxidase labeling methods. The HRP-labeled CCTs made axodendritic synapses preferentially in the ventral part of the cuneate nucleus near the obex. In a total of 182 CCTs surveyed, 14 of them made direct synaptic contacts with immunoperoxidase-labeled glycine-IR dendrites. The present results suggest that cortical modulation on the sensory transmission of cuneate nucleus may be mediated through glycine-IR neurons.
Lue
J H
JH
Department of Anatomy, College of Medicine, National Taiwan University, Taipei, R.O.C.
Lai
S M
SM
Wang
T J
TJ
Shieh
J Y
JY
Wen
C Y
CY
D000818:Animals; D001370:Axonal Transport; D002540:Cerebral Cortex / Q000502:physiology* / Q000648:ultrastructure; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D005727:Ganglia, Spinal / Q000502:physiology; D005998:Glycine / Q000032:analysis*; D007124:Immunoenzyme Techniques; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology* / Q000648:ultrastructure; D008959:Models, Neurological; D009411:Nerve Endings / Q000502:physiology* / Q000648:ultrastructure; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D013116:Spinal Cord / Q000502:physiology; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure*; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D005998:Glycine