[The functional and biochemical characteristics of the development of the tubulointerstitial component in corrosive sublimate-induced nephropathy].
The experiments on 85 non-inbred rat males modelling proximal nephron section impairment--sublimate nephropathy--showed the existence of two pathogenetic mechanisms of TIC development: elevated level in the renal cortex of vasoconstrictive, collagen synthesis stimulating hormone angiotensin 2; weak fibrinolytic activity in the renal papilla underlying fibrin deposit in this renal zone followed by fibrin transformation in collagen.
Rogovyĭ
Iu E
IuE
D000804:Angiotensin II / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005342:Fibrinolysis / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008627:Mercuric Chloride; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D013997:Time Factors
D000804:Angiotensin II; D008627:Mercuric Chloride