title: Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein.
abstract: The nonstructural protein (NS1 protein) of the influenza A virus binds to several types of RNAs. X-ray crystallographic analysis of the RNA-binding domain reveals a unique topology for the monomer as well as a novel six-helix structure for the dimer.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: P A
authors.initials: PA
authors.lastname: Lynch
authors.forename: C Y
authors.initials: CY
authors.lastname: Chien
authors.forename: G T
authors.initials: GT
authors.lastname: Montelione
authors.forename: R M
authors.initials: RM
authors.lastname: Krug
authors.forename: H M
authors.initials: HM
authors.lastname: Berman
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D018360:Crystallography, X-Ray; D019281:Dimerization; D009980:Influenza A virus / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D012313:RNA / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins; D012313:RNA