title: Stem-cell mobilization for autografting in chronic myeloid leukemia.
abstract: In this article, the rationale for autografting in chronic myeloid leukemia is reviewed, and alternative therapeutic approaches to the use of granulocyte-colony stimulating factor and chemotherapy-mobilized peripheral blood stem cells are discussed. The data from patients treated using the original ICE (idarubicin, cytarabine, etoposide), or the shorter course mini-ICE protocols are considered, with special emphasis on those patients who received their chemotherapy regimens soon after diagnosis and prior to any treatment with interferon alpha. The appropriate design of a trial to test the value of autografting in chronic myeloid leukemia is discussed, as is the optimal timing of collections to achieve the maximal yield and purity of Ph-negative peripheral blood stem cells.
authors.affiliation: Hematology and ABMT Unit, Azienda Ospedaliera e Cliniche Universitarie Convenzionate, Ospedale San Martino, Genoa, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Carella
authors.forename: L
authors.initials: L
authors.lastname: Celesti
authors.forename: E
authors.initials: E
authors.lastname: Lerma
authors.forename: A
authors.initials: A
authors.lastname: Dejana
authors.forename: F
authors.initials: F
authors.lastname: Frassoni
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D014182:Transplantation, Autologous