title: Bi-dimensional scaling map (BDS-Map): an approach for building large genetic maps.
abstract: BACKGROUND
  The approaches usually used for building large genetic maps consist of dividing the marker set into linkage groups and provide local orders that can be tested by multi-point linkage analysis. To deal with the limitations of these approaches, a strategy taking the marker set into account globally is defined.
  
  
  RESULTS
  The paper presents a new approach called 'Bi-Dimensional Scaling Map (BDS-Map) for inferring marker orders and distances in genetic maps based on the use of an additional dimension orthogonal to the map into which markers are projected. Dynamical forces based on a two-point analysis are applied to tend to optimize the marker locations in space. The efficiency of the approach is exemplified on real data (16 and 70 markers on chromosomes 6 and 2, respectively) and simulated data (50 maps of 70 markers).
authors.affiliation: Centre de Bioinformatique, INSERM U 155, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Goldberg
authors.forename: P
authors.initials: P
authors.lastname: Ferrand
authors.forename: N Q
authors.initials: NQ
authors.lastname: Nguyen
authors.forename: J F
authors.initials: JF
authors.lastname: Boisvieux
authors.forename: S
authors.initials: S
authors.lastname: Hazout
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D003196:Computer Graphics; D003628:Database Management Systems; D008040:Genetic Linkage; D005819:Genetic Markers; D011381:Programming Languages; D012984:Software; D014584:User-Computer Interface
chemical_list: D005819:Genetic Markers