[The influence of hydrocortisone and dopamine on the behavior of fibrils and values of some sympathetic mediators in kidneys of experimental endotoxic shock].
The aim of the study was to evaluate the influence of hydrocortisone (H) and dopamine (DA) on behaviour of tissue content of DA, NA and homovanillic acid (HVA) as well as adrenergic fibers (AF) in canine kidney during endotoxic shock (ES). Above changes were considered on the background of hemodynamic, biochemical and morphologic alterations. Investigations were carried out on 5 groups of animals: I-control, II-dogs in ES without treatment, III-dogs in ES treated with H, IV-ES treated with DA, V-animals treated with H and DA. It was shown that the amount of catecholamines add AF in group II was lower than in group I. In groups of animal treated we observed bigger of well preserved AF and catecholamines, and the image similar to the one observed in control group-I was observed in group V. It appears from the study conducted that AF show active role to the course of ES, and beneficial effect of the treatment applied can be results of its influence on the function of DA, NA and AF.
Barczyk
J
J
Kliniki Chirurgii Ogólnej Akademii Medycznej w Białymstoku.
Puchalski
Z
Z
D000320:Adrenergic Fibers / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology; D006719:Homovanillic Acid / Q000032:analysis; D006854:Hydrocortisone / Q000378:metabolism* / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000294:innervation / Q000473:pathology / Q000503:physiopathology*; D009638:Norepinephrine / Q000032:analysis; D012772:Shock, Septic / Q000503:physiopathology*
D004298:Dopamine; D006854:Hydrocortisone; D009638:Norepinephrine; D006719:Homovanillic Acid