Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles.
The antiviral activity of a new class of N,N,N',N",NA'''-pentakis (omega-aminoalkyl) tetraazamacrocycles was evaluated in primary duck hepatocyte cultures infected with the duck hepatitis B virus (DHBV). Three of the four tested compounds were able to selectively inhibit DHBV replication by acting at an early step of the hepadnavirus infection but were associated with significant toxicity.
Hantz
O
O
Unité de Recherche sur les Hépatites, le SIDA et les Rétrovirus Humains, Institut National de la Santé et de la Recherche Médicale U271, Lyon, France. hantz@lyon151.inserm.fr
Borel
C
C
Trabaud
C
C
Zoulim
F
F
Dessolin
J
J
Camplo
M
M
Vlieghe
P
P
Bouygues
M
M
Trepo
C
C
Kraus
J L
JL
D000998:Antiviral Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004279:DNA, Viral / Q000187:drug effects; D015611:Hepatitis B Virus, Duck / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D001372:Aza Compounds; D004279:DNA, Viral; D006571:Heterocyclic Compounds