Relationship of transforming growth factor beta 1 to angiogenesis in gastric carcinoma.
Transforming growth factor-beta (TGF-beta) comprises a group of multifunctional regulatory proteins, whose effects include angiogenesis. The expression of TGF-beta 1 in gastric carcinomas (70 cases) has been determined and related to pathological features and microvessel count by immunohistochemical staining for TGF-beta 1 and Factor VIII related antigen. Prominent reactivity for TGF-beta 1 was associated with the depth of invasion (r = 0.2; p < 0.05) and increased microvessel count (r = 0.5; p < 0.05). Also, the microvessel count had a significant correlation with invasiveness (r = 0.34; p < 0.05) and lymph node metastasis (r = 0.28; p < 0.05). These findings indicate that TGF-beta 1 may have a role in tumor invasion and angiogenesis.
Choi
Y H
YH
Department of Pathology, College of Medicine, Hallym University, Korea. yhchoi@www.hallym.or.kr
Choi
K C
KC
Park
Y E
YE
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000098:blood supply* / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000209:etiology; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta