title: Ovulation induction in a woman with premature ovarian failure resulting from a partial deletion of the X chromosome long arm, 46,X,del(X)(q22).
abstract: OBJECTIVE
  To report successful ovulation induction in a woman with premature ovarian failure (POF) resulting from a partial Xq deletion.
  
  
  METHODS
  An uncontrolled study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A 27-year-old woman with 46,X,del(X)(q22) who had hypergonadotropic secondary amenorrhea.
  
  
  METHODS
  Injections of hMG (225 IU/d) for 8 consecutive days after endogenous gonadotropin suppression with a long-acting GnRH agonist (900 micrograms/d) for 12 weeks, together with cyclic sex steroid replacement therapy.
  
  
  METHODS
  Serum concentrations of E2 and P as well as ultrasonography.
  
  
  RESULTS
  Folliculogenesis and ovulation.
  
  
  CONCLUSIONS
  Ovulation induction is possible in patients with POF caused by X chromosome aberrations.
authors.affiliation: Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: B
authors.initials: B
authors.lastname: Ishizuka
authors.forename: Y
authors.initials: Y
authors.lastname: Kudo
authors.forename: A
authors.initials: A
authors.lastname: Amemiya
authors.forename: T
authors.initials: T
authors.lastname: Ogata
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D010062:Ovulation Induction; D016649:Primary Ovarian Insufficiency / Q000000981:diagnostic imaging / Q000235:genetics* / Q000628:therapy; D011374:Progesterone / Q000097:blood; D016896:Treatment Outcome; D014463:Ultrasonography; D014960:X Chromosome
chemical_list: D011374:Progesterone; D004958:Estradiol; D008596:Menotropins