[Chronic eosinophilic pneumonia associated with high concentrations of interleukin-5, -6, and granulocyte colony stimulating factor in serum and in pleural fluid].
A 44-year-old Japanese man who had suffered from bronchial asthma since childhood was given the diagnosis of chronic eosinophilic pneumonia because of his symptoms, chest roentgenographic findings, and the results of a transbronchial lung biopsy. At the time of the onset of the disease, the pleural effusion contained 73% eosinophils. Symptoms were relieved and the laboratory findings returned forward normal after a short course of high-dose corticosteroids. The concentrations of IL-5, IL-6, and G-CSF in pleural fluid and in serum were very high; the concentrations of these cytokines were 3 times to 35 times higher in pleural fluid than in serum. In contrast, no IL-3 or GM-CSF was detected in any of these samples. The precise etiology of chronic eosinophilic pneumonia is still unclear, but this case suggests that inappropriate production of IL-5, IL-6 and G-CSF in the lung play a pivotal role in this disease. Inhibition of the production of these cytokines may be another therapeutic approach to this disease.
Ino-oka
N
N
Sendai City Medical Center, Sendai Open Hospital, Japan.
Inoue
A
A
Shindoh
Y
Y
Suzuki
T
T
Konishi
K
K
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002908:Chronic Disease; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D015848:Interleukin-5 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D010996:Pleural Effusion / Q000737:chemistry*; D011239:Prednisolone / Q000008:administration & dosage; D011657:Pulmonary Eosinophilia / Q000188:drug therapy / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D015848:Interleukin-5; D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor; D011239:Prednisolone