[Influence of neuronal excitation and inhibition of rostral ventrolateral medulla on the effect of electroacupuncture of "Neiguan" acupoint].
Experiments were performed on 44 rabbits anesthetized with a mixture of urethane and chloralose. The effects of microinjection of glutamate and glycine in bilateral rostral ventrolateral medulla (rVLM) on the reaction of electroacupuncture (EA) of "Neiguan" acupoint (PC 6) after myocardial ischemia by ligature of the left ventricular branch of coronary artery were observed. Results showed that (1) EA could significantly promote the recovery of ECG ST-segments, mean blood pressure (MBP), left ventricular pressure (LVP) and the maximum rising rate of LVP (dp/dt max); (2) Glutamate could enhance the effects of EA on MBP, LVP and dp/dt max to a certain extent; (3) The effects of EA could be weakened significantly by glycine. It suggests that EA-induced improvement of the cardiovascular function can be strengthened further in some degree when neurons of rVLM are excited and weakened pronouncedly while the neurons are inhibited. Therefore, rVLM participates in the regulatory process of EA on functional activity of the heart.
Liu
J
J
Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing.
Chen
S
S
Cao
Q
Q
Zhang
J
J
D015669:Acupuncture Points; D000818:Animals; D001794:Blood Pressure; D015671:Electroacupuncture; D005260:Female; D005971:Glutamates / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D008845:Microinjections; D017202:Myocardial Ischemia / Q000503:physiopathology; D011817:Rabbits; D016277:Ventricular Function, Left
D005971:Glutamates; D005998:Glycine