title: Protective effect of antioxidant vitamins on red blood cell lipoperoxidation induced by SO2 inhalation.
abstract: The aim of this research was to determine whether administration of antioxidant vitamins can reduce oxidant damage in erythrocytes induced by sulfur dioxide (SO2) inhalation. Meth- and sulfhemoglobin ratios, malonyldialdehyde (MDA) levels, osmotic fragility ratios and hematological parameters of a total of 28 rats were compared. SO2 was given at 10 ppm, 1 hour daily, for 45 days in a specially designed chamber. DL-alpha-Tocopherol acetate (40 mg/kg) and Na-ascorbate (200 mg/kg) treatments, initiated 3 days before SO2 exposures, were applied intraperitoneally 3 times a week for 45 days. Meth- and sulfhemoglobin ratios, MDA levels and osmotic fragility ratios were significantly higher in the SO2-treated group (p < 0.05). Significant decreases in MDA levels and osmotic fragility ratios were observed in the antioxidant-treated group (p < 0.05). SO2 inhalation resulted in higher MDA levels and osmotic fragility ratios, which can be reduced by vitamin E + C combination.
authors.affiliation: Department of Physiology, Faculty of Medicine, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Etlik
authors.forename: A
authors.initials: A
authors.lastname: Tomur
authors.forename: M
authors.initials: M
authors.lastname: Tuncer
authors.forename: A Y
authors.initials: AY
authors.lastname: Ridvanağaoğlu
authors.forename: O
authors.initials: O
authors.lastname: Andaç
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D007958:Leukocyte Count; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D008706:Methemoglobin / Q000032:analysis; D009996:Osmotic Fragility / Q000187:drug effects; D051381:Rats; D013435:Sulfhemoglobin / Q000032:analysis; D013458:Sulfur Dioxide / Q000009:adverse effects*; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D000393:Air Pollutants; D000975:Antioxidants; D014815:Vitamins; D013458:Sulfur Dioxide; D008315:Malondialdehyde; D008706:Methemoglobin; D013435:Sulfhemoglobin