title: Proteins unfold in steps.
abstract: I present results from an experiment on the dynamics of folding of a globular protein (bovine serum albumin). Employing a micro-mechanical technique, I perform the measurements on very few molecules (1-100). I observed a sequence of steps in time for both unfolding and refolding. The overall characteristic time of the process is thus built up of waiting times between successive steps. The pattern of steps is reproducible, demonstrating the existence of deterministic pathways for folding and unfolding. Certain symmetries in the patterns of steps may reflect the architecture of the protein's structure.
authors.affiliation: Center for Chaos and Turbulence Studies, Niels Bohr Institute, Blegdamsvej 17, 2100 Copenhagen O, Denmark. zocchi@nbi.dk
authors.forename: G
authors.initials: G
authors.lastname: Zocchi
mesh_terms: D017510:Protein Folding; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D012710:Serum Albumin, Bovine