Electron-microscopic study of MAOB-containing structures in the nucleus accumbens shell: using MAOA-deficient transgenic mice.
MAOB-containing structures in the nucleus accumbens were ultrastructurally studied for the first time, using MAOA-deficient transgenic mice and MAO enzyme histochemistry. Among the striatal structures, the nucleus accumbens, and in particular its dorsal shell, showed the strongest MAOB activity. MAOB-active cell bodies were embedded in a dense MAOB-active fiber plexus. MAOB-positive terminals formed axo-dendritic synapses which were exclusively of the asymmetric type. It is suggested that dopamine in the nucleus accumbens shell is transported into MAOB-positive fibers where it is degraded by MAOB.
Ikemoto
K
K
Département de Médecine Expérimentale, INSERM U52, CNRS ERS 5645, Université Claude Bernard, Lyon, France. kikemoto@fujita-hu.ac.jp
Kitahama
K
K
Maeda
T
T
Tokunaga
Y
Y
Valatx
J L
JL
De Maeyer
E
E
Seif
I
I
D000818:Animals; D001369:Axons / Q000201:enzymology* / Q000648:ultrastructure; D003712:Dendrites / Q000201:enzymology* / Q000648:ultrastructure; D005260:Female; D007527:Isoenzymes / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008854:Microscopy, Electron; D008995:Monoamine Oxidase / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D009411:Nerve Endings / Q000201:enzymology* / Q000648:ultrastructure; D009714:Nucleus Accumbens / Q000201:enzymology* / Q000648:ultrastructure; D013569:Synapses / Q000201:enzymology / Q000648:ultrastructure; D013572:Synaptic Vesicles / Q000201:enzymology / Q000648:ultrastructure
D007527:Isoenzymes; D008995:Monoamine Oxidase