title: Tailored augmentation of the lower esophageal sphincter in experimental antireflux operations.
abstract: BACKGROUND
  Modern upper GI function studies allow for the detection of several pathophysiological factors that contribute to gastroesophageal reflux disease. The information obtained can lead to therapeutic consequences in patients with an indication for a surgical intervention, i.e., an individualized choice of antireflux procedure according to the existing pathophysiologic defect.
  
  
  METHODS
  In an experimental study on mini-pigs the mechanical effect of four standardized antireflux operations (anterior and posterior 180 degrees hemifundoplication, Nissen-DeMeester and Nissen-Rossetti 360 degrees fundoplication) on the lower esophageal sphincter (LES) was investigated. It was the aim of the study to objectively determine the extent of changes in pressure and length parameters at the LES according to the performed antireflux procedure.
  
  
  RESULTS
  It could be demonstrated that different degrees of fundic wrap formation lead to a proportional mechanical effect at the LES according to the size of this wrap.
  
  
  CONCLUSIONS
  Choosing a distinct type of fundoplication will allow for a tailored augmentation of the LES according to the individual functional defect.
authors.affiliation: Department of Surgery, University of Würzburg, Josef-Schneider-Str. 2, D-97080 Würzburg, Germany.
authors.forename: S M
authors.initials: SM
authors.lastname: Freys
authors.forename: K H
authors.initials: KH
authors.lastname: Fuchs
authors.forename: J
authors.initials: J
authors.lastname: Heimbucher
authors.forename: A
authors.initials: A
authors.lastname: Thiede
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D016145:Endoscopy, Digestive System; D004943:Esophagogastric Junction / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D004947:Esophagus / Q000601:surgery; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000601:surgery*; D010535:Laparoscopy; D008365:Manometry; D011312:Pressure; D013536:Suture Techniques; D013552:Swine; D013556:Swine, Miniature