Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on neutrophil formation and function.
Work published in the past year has significantly increased our understanding of the intracellular signaling pathways that are activated following granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor binding to cell surface receptors. The involvement of nonreceptor protein tyrosine kinases, in particular the JAK2 kinase, appears to be a major signal transduction pathway involved in the response to several hemopoietic cytokines. Further data continue to accrue on the clinical role of granulocyte colony-stimulating factor, in particular in the treatment of chronic neutropenia. Increased clinical experience with colony-stimulating factors has revealed side effects that may occur with chronic use. The effects of colony-stimulating factors on neutrophil function are shown increasingly to be complex and to involve significant interactions with other proinflammatory cytokines.
Khwaja
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Department of Haematology, University College London Medical School, UK.
Linch
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DC
D000380:Agranulocytosis / Q000139:chemically induced; D000818:Animals; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects
D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor