Composite mantle-cell lymphoma and plasmacytoma.
We report a case of a composite lymphoma comprising both mande cell lymphoma and a plasmacytoma. The two components were morphologically and immunohistochemically quite distinct. These properties, coupled with both direct and indirect molecular genetic evidence, suggest that these were two separate tumours occurring together by chance or by unknown oncogenic mechanisms, rather than clonally linked lymphomas.
Cachia
A R
AR
Department of Tissue Pathology, Institute of Clinical Pathology & Medical Research, Westmead Hospital, Australia.
Diss
T C
TC
Isaacson
P G
PG
D015415:Biomarkers / Q000032:analysis*; D001706:Biopsy; D019938:Cyclin D1 / Q000032:analysis; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000737:chemistry / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction
D015415:Biomarkers; D007143:Immunoglobulin Heavy Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D019938:Cyclin D1