title: [Lung cancer in the province of Trieste].
abstract: In our study we analyzed a file of 756 males with lung cancer and an equal number of controls matched by sex, age and year of death. All the subjects were resident in the Trieste area, died between 1979-81 and 1985-86 and underwent autopsy at the Istitute of Pathological Anatomy of the University of Trieste. The aim of the research was to analyze and quantify the risk to develop lung cancer in those exposed to asbestos, and well-recognized carcinogens (list A of I.A.R.C.) or suspected (list B). We have also analyzed the relative risk (R.R.) for lung cancer among those subjects with environmental exposure to air pollution in industrial and urban areas. The study was set up in the Trieste province, a geographic area which is particularly suitable for epidemiological studies. We have demonstrated on excess of risk for males exposed to asbestos (R.R. = 1.99) and to other well known carcinogens (R.R. = 2.28). The capability in differentiating the relative risk of smoking and professional exposure to oncogenetic substances allowed us to detect an excess of risk for people living in industrial and urban areas, when compared to those living in rural and peripheral areas.
authors.affiliation: Istituto di Anatomia e Istologia Patologica, Università degli Studi di Trieste.
authors.forename: L
authors.initials: L
authors.lastname: Di Bonito
authors.forename: L
authors.initials: L
authors.lastname: Giarelli
authors.forename: G
authors.initials: G
authors.lastname: Stanta
authors.forename: F
authors.initials: F
authors.lastname: Cavallieri
authors.forename: F
authors.initials: F
authors.lastname: Zanconati
authors.forename: P
authors.initials: P
authors.lastname: Peruzzo
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects; D000397:Air Pollution / Q000009:adverse effects; D001194:Asbestos / Q000009:adverse effects; D001195:Asbestosis / Q000150:complications; D002273:Carcinogens / Q000009:adverse effects; D016022:Case-Control Studies; D004781:Environmental Exposure; D006801:Humans; D007221:Industry; D007558:Italy / Q000453:epidemiology; D008175:Lung Neoplasms / Q000209:etiology / Q000401:mortality*; D008297:Male; D016273:Occupational Exposure; D012189:Retrospective Studies; D012306:Risk; D012424:Rural Population; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D014505:Urban Population
chemical_list: D000395:Air Pollutants, Occupational; D002273:Carcinogens; D001194:Asbestos