[Expression of c-erbB-2 oncogene and mutation of p53 gene in myoepithelioma and myoepithelial carcinoma].
Expression of c-erbB-2 oncogene and mutant p53 protein were detected immunohistochemically in 14 cases of myoepithelioma and 6 cases of myoepithelial carcinoma of the salivary gland. Five of the 6 myoepithelial carcinomas and nine of the 14 myoepitheliomas were overexpression of c-erbB-2 oncoprotein. The salivary ductal epithelial cells near tumors were overexpression of c-erbB-2 oncoprotein. These results indicate that c-erbB-2 may be an initial oncogene during the histogenesis of myoepithelial tumors. The p53 protein was positive in five cases of the 6 myoepithelial carcinoma, whereas all myoepitheliomas were negative. The results indicate that the mutant p53 gene may play an important role in the carcinogenesis of myoepithelial carcinoma.
Wang
J
J
Hebei Medical University, Shijiazhuang.
Dong
F
F
Wang
X
X
D002277:Carcinoma / Q000235:genetics*; D015870:Gene Expression; D018734:Genes, erbB-2; D016158:Genes, p53; D006801:Humans; D009154:Mutation; D009208:Myoepithelioma / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D012468:Salivary Gland Neoplasms / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53