[Changes in the level of selected laboratory parameters in blood after implantation of chitosan fibers].
The tests were carried out on rats of the Wistar tribe to the peritoneal cavity of which chitosan fibres were implanted. The blood for the tests was taken in 3, 7, 14, 30 and 60 days after the implantation. In the blood hematological, biochemical and clotting system parameters were marked. Moreover they made pathomorphological tests of the tissues surrounding the implanted material and laboratory and biological tests of aqueous extracts from chitosan fibres. The shown quantitative changes in the level of the marked parameters of blood to the 14th day of observation are connected mainly with toxicity of chitosan fibres, whereas to the 30th and 60th day-with the process of biodegradation and resorption of collagenous fibres.
Szymonowicz
M
M
Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów, Katedra Chirurgii Urazowej Akademii Medycznej we Wrocławiu.
Paluch
D
D
Misterka
S
S
Staniszewska-Kuś
J
J
Majda
J
J
D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000187:drug effects; D001672:Biocompatible Materials; D001777:Blood Coagulation / Q000187:drug effects; D001786:Blood Glucose / Q000187:drug effects; D001790:Blood Physiological Phenomena / Q000187:drug effects*; D001798:Blood Proteins / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002686:Chitin / Q000031:analogs & derivatives* / Q000633:toxicity; D048271:Chitosan; D003404:Creatinine / Q000097:blood; D007958:Leukocyte Count / Q000187:drug effects; D008274:Magnesium / Q000097:blood; D011188:Potassium / Q000097:blood; D019736:Prostheses and Implants; D051381:Rats; D012964:Sodium / Q000097:blood; D014508:Urea / Q000097:blood
D001672:Biocompatible Materials; D001786:Blood Glucose; D001798:Blood Proteins; D002686:Chitin; D014508:Urea; D048271:Chitosan; D012964:Sodium; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008274:Magnesium; D011188:Potassium; D002118:Calcium