title: Photosensitive polyurethanes applied to the development of CHEMFET and ENFET devices for biomedical sensing.
abstract: Chemical microsensors based on ion-selective field effect transistor (ISFET) transducers with ion-selective and enzymatic membranes have been fabricated. In this case, photolithographically patterned membranes based on acrylated urethanes have been developed and applied onto the gate area of ISFET chips. Aliphatic urethane diacrylate has been used for K+ and NH+4 membranes, while a photocurable hydrogel formulation based on other type of acrylated urethane has been optimized for urea-FET sensors. Resulting potassium and ammonium sensors show similar performances to those found when PVC membranes are employed. An integrated packaging process for ISFET-based sensors has been developed giving the possibility of carrying out most of the encapsulation on wafer level. For this purpose, a photocurable polyurethane encapsulant formulation has been optimized to be microstructured by photolithography. Finally, a preliminary study of biocompatibility of photosensitive formulations containing urethane oligomers has been performed in order to examine future applications in biomedical and clinical analysis.
authors.affiliation: Centro Nacional de Microelectrónica-CSIC, Bellaterra, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Muñoz
authors.forename: C
authors.initials: C
authors.lastname: Jimenez
authors.forename: A
authors.initials: A
authors.lastname: Bratov
authors.forename: J
authors.initials: J
authors.lastname: Bartrolí
authors.forename: S
authors.initials: S
authors.lastname: Alegret
authors.forename: C
authors.initials: C
authors.lastname: Dominguez
mesh_terms: D015374:Biosensing Techniques; D004563:Electrochemistry; D007476:Ionophores; D008422:Materials Testing; D008567:Membranes, Artificial; D010777:Photochemistry; D011140:Polyurethanes; D014159:Transducers; D014173:Transistors, Electronic; D014508:Urea
chemical_list: D007476:Ionophores; D008567:Membranes, Artificial; D011140:Polyurethanes; D014508:Urea