Follicular mucinosis associated with scarring alopecia, oligoclonal T-cell receptor V beta expansion, and Staphylococcus aureus: when does follicular mucinosis become mycosis fungoides?
A diagnosis of alopecia mucinosa, occurring as a single scalp lesion, was made in a 40-year-old white woman who had a history of trauma. Follicular mucinosis, Staphylococcus aureus, and oligoclonal expansion of the T-cell receptor V beta chain genes 6 and 7 were present in the skin. Epidermotropic T-cell skin diseases with oligoclonal T-cell proliferations may be the result of HLA- and cytokine-determined reaction patterns to persistent antigens.
Jackow
C M
CM
Department of Dermatology, University of Texas Medical School, Houston 77030, USA.
Papadopoulos
E
E
Nelson
B
B
Tschen
J A
JA
Heatherington
G
G
Duvic
M
M
D000328:Adult; D000505:Alopecia / Q000209:etiology* / Q000473:pathology; D001706:Biopsy; D002921:Cicatrix / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D000507:Mucinosis, Follicular / Q000175:diagnosis* / Q000382:microbiology; D009182:Mycosis Fungoides / Q000276:immunology / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000276:immunology / Q000473:pathology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012535:Scalp / Q000293:injuries / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013601:T-Lymphocytes / Q000473:pathology
D011948:Receptors, Antigen, T-Cell