C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.
The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.
Brandsen
J
J
Werten
S
S
van der Vliet
P C
PC
Meisterernst
M
M
Kroon
J
J
Gros
P
P
D000595:Amino Acid Sequence; D001665:Binding Sites; D018360:Crystallography, X-Ray; D004277:DNA, Single-Stranded / Q000378:metabolism*; D019281:Dimerization; D006801:Humans; D017874:Immediate-Early Proteins; D008565:Membrane Proteins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D012097:Repressor Proteins; D015534:Trans-Activators / Q000737:chemistry*
D004277:DNA, Single-Stranded; C490043:IFRD2 protein, human; D017874:Immediate-Early Proteins; D008565:Membrane Proteins; D012097:Repressor Proteins; D015534:Trans-Activators