The role of H. pylori infection in the pathophysiology of duodenal ulcer disease.
The discovery of H. pylori infection and the recognition of its effects on gastric physiology has significantly advanced our understanding of the pathophysiology of ulcer disease, In DU patients H. pylori gastritis is mainly confined to the antral mucosa. It stimulates increased release of gastrin by the antral mucosa and this is accompanied by high acid output by the oxyntic mucosa. This high acid response to gastrin stimulation by the oxyntic mucosa in DU patients is due to the combination of a high parietal cell mass and the fact that the function of these parietal cells is not impaired by any body gastritis. The increased acid secretion results in an increased duodenal acid load with the development of gastric metaplasia within the duodenal bulb and then actual ulceration. The reason why only some subjects develop this antral predominant pattern of H. pylori gastritis and associated acid hypersecretion is unclear but may be explained by a premorbid high acid output protecting the oxyntic mucosa form H. pylori gastritis.
McColl
K E
KE
Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK.
el-Omar
E M
EM
Gillen
D
D
D004381:Duodenal Ulcer / Q000378:metabolism / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism / Q000503:physiopathology; D005755:Gastrins / Q000097:blood / Q000378:metabolism; D016481:Helicobacter Infections / Q000378:metabolism / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D011706:Pyloric Antrum / Q000378:metabolism
D005755:Gastrins