title: Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters?
abstract: The overexpression of specific transport proteins in the membrane of many cancer cells renders these cells resistant to many therapeutic drugs. Some lipid-modified cysteine compounds inhibit one drug-transporting protein, indicating the potential of developing such compounds as therapeutic agents.
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham NC 27710-3686, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Hurwitz
authors.forename: P J
authors.initials: PJ
authors.lastname: Casey
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D003545:Cysteine / Q000378:metabolism*; D018432:Drug Resistance, Multiple; D006801:Humans; D008024:Ligands; D017368:Protein Prenylation
chemical_list: D018528:ATP-Binding Cassette Transporters; D008024:Ligands; D003545:Cysteine