Efficacy of two commercial products for altering urine drug test results.
OBJECTIVE
We have become aware of several commercial products that, when orally ingested, will purportedly not only eliminate "toxins" from a person's system, but will also correct any urinary imbalances caused by excessive water consumption.


METHODS
Unblinded study of one volunteer subject, tested weekly x 4 for 24-hour urine elimination of test drug under conditions of control, control plus 1200 mL water, Quick Flush', and Eliminator.


RESULTS
Each of the treatment protocols studied caused reductions of drug or metabolite concentrations as measured by gas chromatography-mass spectrometry in urine specimens collected up to 24 hours after ingestion of amphetamine, 9-carboxy-11-nor-delta-9-THC, benzoylecgonine, or codeine, yet the radioimmunoassay screening results demonstrated very little effect. Water alone was approximately as effective as the two commercial products in reducing the metabolite level. None of the treatment protocols employed in this study altered urinary pH, specific gravity, or creatinine concentration outside the normally accepted physiological range.


CONCLUSIONS
Attempts to conceal drug abuse by water dilution are most likely to play a substantial role when concentrations are at or near the detection threshold for a particular assay such as the terminal stages of drug eliminations.
Coleman
D E
DE
Chemical Toxicology Institute Foster City, California 94404, USA.
Baselt
R C
RC
D000661:Amphetamine / Q000652:urine; D003042:Cocaine / Q000031:analogs & derivatives / Q000652:urine; D003061:Codeine / Q000652:urine; D003404:Creatinine / Q000652:urine; D013759:Dronabinol / Q000652:urine; D004335:Drug and Narcotic Control / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013287:Illicit Drugs / Q000652:urine*; D008297:Male; D011863:Radioimmunoassay; D015813:Substance Abuse Detection / Q000379:methods; D019966:Substance-Related Disorders / Q000652:urine*; D016482:Urinalysis / Q000379:methods*
D013287:Illicit Drugs; C005618:benzoylecgonine; D013759:Dronabinol; D003404:Creatinine; D000661:Amphetamine; D003042:Cocaine; D003061:Codeine