Pivotal role of interleukin-8 in the acute respiratory distress syndrome and cerebral reperfusion injury.
Neutrophil recruitment is one of the hallmarks of acute inflammation. A potent neutrophil chemotactic and activating factor, interleukin-8 (IL-8), has been demonstrated to be elevated in body fluids in various human diseases and experimental animal models. Recent investigations on animal disease models using blocking antibodies to IL-8 have revealed the essential involvement of IL-8 in acute inflammation. We previously reported that the administration of a neutralizing antibody against IL-8 prevented the neutrophil infiltration and neutrophil-mediated tissue injury in several animal studies. In addition, we have recently demonstrated that anti-IL-8 treatment is also effective in prevention of two models that are very relevant to clinical situations: cerebral reperfusion injury and endotoxemia-induced acute respiratory distress syndrome-like lung injury. These results further support the hypothesis that IL-8 has a pivotal role and is a novel target for therapeutic intervention in neutrophil-mediated injury.
Matsumoto
T
T
Department of Neurosurgery, School of Medicine, Cancer Research Institute, Kanazawa University, Japan.
Yokoi
K
K
Mukaida
N
N
Harada
A
A
Yamashita
J
J
Watanabe
Y
Y
Matsushima
K
K
D000818:Animals; D001921:Brain / Q000098:blood supply; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology*; D006801:Humans; D016209:Interleukin-8 / Q000502:physiology*; D015427:Reperfusion Injury / Q000473:pathology*; D012128:Respiratory Distress Syndrome / Q000473:pathology*
D016209:Interleukin-8