Ribozymes, recognition and evolution.
Precision in the recognition and orientation of substrate is important in the selectivity of catalysis by natural enzymes. Several new ribozyme species have been evolved using in vitro selection/mutagenesis which make use of precise substrate recognition to catalyze a variety of reactions.
Iverson
B L
BL
Department of Chemistry and Biochemistry, University of Texas, Austin 78712, USA.
D000818:Animals; D005075:Biological Evolution; D002384:Catalysis; D006801:Humans; D012313:RNA / Q000096:biosynthesis; D016337:RNA, Catalytic / Q000502:physiology*
D016337:RNA, Catalytic; D012313:RNA