Plasma adrenomedullin levels in patients with hepatic cirrhosis.
OBJECTIVE
The role of adrenomedullin in cirrhosis is at present unknown. The aim of this study was to investigate plasma levels of adrenomedullin in cirrhosis.


METHODS
We measured plasma adrenomedullin concentrations using radioimmunoassay in 43 patients with cirrhosis (17 in Child-Pugh's class A, 13 in Child-Pugh's class B, and 13 in Child-Pugh's class C) and compared these values with those in 24 age-matched healthy subjects. Renal function, plasma cyclic adenosine monophosphate (cAMP) concentration, plasma renin activity, and plasma aldosterone concentration were measured in each patient.


RESULTS
Plasma adrenomedullin levels were increased significantly in patients with cirrhosis compared with healthy subjects. In addition, plasma adrenomedullin values were higher in patients with cirrhosis and ascites than in those without ascites. Moreover, plasma adrenomedullin levels increased in relation to the severity of cirrhosis. Significant positive correlations also were found between adrenomedullin and cAMP concentrations and plasma renin activity or plasma aldosterone concentrations.


CONCLUSIONS
Plasma adrenomedullin is increased in patients with cirrhosis compared with healthy subjects. The increase in plasma adrenomedullin levels is related at least in part to the severity of cirrhosis and may contribute to the arteriolar vasodilation in patients with cirrhosis. These effects are related in part to a cAMP-dependent pathway.
Fábrega
E
E
Gastroenterology and Hepatology Unit, Faculty of Medicine, University Hospital Marqués de Valdecilla, Santander, Spain.
Casafont
F
F
Crespo
J
J
de la Peña
J
J
San Miguel
G
G
de las Heras
G
G
García-Unzueta
M T
MT
Amado
J A
JA
Pons-Romero
F
F
D053607:Adrenomedullin; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D001201:Ascites / Q000150:complications; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood; D012709:Serum Albumin / Q000032:analysis
D010455:Peptides; D012709:Serum Albumin; D053607:Adrenomedullin; D000450:Aldosterone; D012083:Renin