Abnormalities of apolipoprotein E in the acquired immunodeficiency syndrome.
Given the important role of apolipoprotein E (apoE) in triglyceride metabolism, we analyzed plasma levels and degree of sialylation of apoE in subjects with the acquired immunodeficiency syndrome (AIDS), a disorder accompanied by hypertriglyceridemia. Levels of apoE were significantly increased (1.84-fold) and correlated with plasma triglycerides (r = .663, P < .001) in AIDS. Subjects with AIDS and the apoE3/E2 phenotype showed the most prominent increases in both plasma triglyceride and apoE levels (3.4 and 2.2-fold over controls). Additionally, apoE from subjects with AIDS showed an increased amount of sialylation, compared with controls (34% increase in apoE3/E3 subjects). Increased sialylation correlated with the increase in apoE levels. In contrast, there was no increase in sialylation of apo C-III in AIDS. Thus, triglyceride levels in AIDS are influenced by apoE subtype and subjects with AIDS show changes in apoE structure.
Grunfeld
C
C
Department of Medicine, University of California, San Francisco, USA.
Doerrler
W
W
Pang
M
M
Jensen
P
P
Weisgraber
K H
KH
Feingold
K R
KR
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000150:complications; D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood* / Q000235:genetics; D015153:Blotting, Western; D002784:Cholesterol / Q000097:blood; D004591:Electrophoresis, Polyacrylamide Gel; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications; D007525:Isoelectric Focusing; D019158:N-Acetylneuraminic Acid / Q000097:blood; D014280:Triglycerides / Q000097:blood
D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; D001057:Apolipoproteins E; D014280:Triglycerides; D002784:Cholesterol; D019158:N-Acetylneuraminic Acid