title: Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus.
abstract: IGF-I has been shown to enhance neuronal survival and inhibit apoptosis. IGF-I immunoreactivity was examined in the Alzheimer's disease and normal post-mortem human hippocampus and temporal cortex to determine whether IGF-I protein levels are altered in response to neurodegeneration. IGF-I immunoreactivity was induced in a subpopulation of GFAP-immunopositive astroglia in the Alzheimer's disease temporal cortex. These observations raise the possibility that IGF-I has a neuroprotective role in the Alzheimer's disease brain.
authors.affiliation: Department of Pharmacology, Faculty of Medicine and Health Science, University of Auckland, New Zealand.
authors.forename: B
authors.initials: B
authors.lastname: Connor
authors.forename: E J
authors.initials: EJ
authors.lastname: Beilharz
authors.forename: C
authors.initials: C
authors.lastname: Williams
authors.forename: B
authors.initials: B
authors.lastname: Synek
authors.forename: P D
authors.initials: PD
authors.lastname: Gluckman
authors.forename: R L
authors.initials: RL
authors.lastname: Faull
authors.forename: M
authors.initials: M
authors.lastname: Dragunow
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D000911:Antibodies, Monoclonal; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D003429:Cross Reactions; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D012016:Reference Values; D013702:Temporal Lobe / Q000166:cytology / Q000378:metabolism / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D005904:Glial Fibrillary Acidic Protein; D007334:Insulin-Like Growth Factor I