title: Differential modulation of short and long latency sensory responses in the SI cortex by IL-6.
abstract: The effects of topical application of interleukin-6 (IL-6) on the short and long latency evoked unit responses of the neurones in the primary somatosensory (SI) cortex were determined quantitatively in anaesthetized rats. IL-6 (0.01, 0.1, 1.0 units) significantly suppressed (-15.13 +/- 3.4%) short latency afferent sensory responses, while it induced profound facilitation (+464.74 +/- 132.7%) of long latency responses in a dose-dependent manner. IL-6-induced afferent modulations fully recovered by 60 min after drug administration. In control experiments, saline solution containing 0.2% bovine serum albumin, used as a vehicle, did not affect afferent sensory transmission. Implications of these results are discussed with reference to the different somatosensory functions of short and long latency response components in the SI cortex.
authors.affiliation: Department of Physiology, College of Medicine, Chunchon Sacred Heart Hospital, Kangwon-do, Korea.
authors.forename: H C
authors.initials: HC
authors.lastname: Shin
authors.forename: S
authors.initials: S
authors.lastname: Oh
authors.forename: S C
authors.initials: SC
authors.lastname: Jung
authors.forename: J
authors.initials: J
authors.lastname: Park
authors.forename: C K
authors.initials: CK
authors.lastname: Won
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects; D015850:Interleukin-6 / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology; D013003:Somatosensory Cortex / Q000166:cytology / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D015850:Interleukin-6; D011994:Recombinant Proteins