[The mechanisms of the interaction of sex hormones with serum albumin and gamma-globulins studied by the methods of equilibrium dialysis and fluorescence quenching].
The molecular mechanisms of sex hormones (testosterone, progesterone, 17 beta-estradiol) binding with human serum albumin and gamma-globulins were studied. According to the data of equilibrium dialysis, all the sex hormones under study bind with the blood plasma proteins, mainly with the serum albumin. In interaction of the sex hormones with serum albumin and gamma globulins, conformation changes of the proteins occur increasing their molecular affinity.
Karachentsev
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AN
Mel'chenko
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IA
D003956:Dialysis; D004347:Drug Interactions; D004958:Estradiol / Q000097:blood*; D006801:Humans; D011374:Progesterone / Q000097:blood*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013739:Testosterone / Q000097:blood*; D005719:gamma-Globulins / Q000378:metabolism*
D012709:Serum Albumin; D005719:gamma-Globulins; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol