The genetic basis of head and neck carcinoma.
Research over the past few years has pointed to a genetic basis for numerous cancers. Efforts in this regard are ongoing in squamous carcinoma of the head and neck. Today surgeons and residents in training need to stay up to date on molecular biology and the genetic sequences that are necessary to form a malignancy. In addition, these changes offer diagnosticians and therapists novel ways both to diagnose and treat malignancies. An evolution in molecular genetics, tumor virology, and tumor biology has led to our understanding of how malignancies arise. There are two pathways of cancer production: the activation of an oncogene or the mutation of a tumor suppressor gene. This review discusses the interaction of these genetic changes in the development of squamous carcinoma of the head and neck, their relationship to tobacco and alcohol use, as well as methods to detect the presence of malignancy and novel techniques that may be used to treat malignancies in the future.
Saunders
J R
JR
Milton J. Dance, Jr., Head and Neck Rehabilitation Center, Greater Baltimore Medical Center, Maryland, USA.
D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009857:Oncogenes; D012907:Smoking