Effect of low grade radiofrequency heating on arterial vasospasm in the porcine model.
Nineteen pigs were studied in order to assess the effect of low grade, radiofrequency-powered, thermal balloon angioplasty on the vasoconstrictor response of peripheral arteries. A mechanical stimulus was used to induce vasospasm. Thermal angioplasty reduced the extent of inducible vasospasm from 79% to 6% compared to nonthermal control inflations, which reduced the vasoconstrictor response from 75% to 60% (P < 0.001). Histologic studies demonstrated that the extent of myocyte necrosis was significantly greater in the thermally treated arteries than in the control vessels (P < 0.01). Thermal balloon angioplasty at 60 degrees C significantly attenuates peripheral arterial vasospasm induced by mechanical trauma in the porcine model. This paralytic effect may be related to the loss of myocytes secondary to thermal necrosis.
Mitchel
J F
JF
Department of Internal Medicine, Hartford Hospital, Connecticut 06102, USA.
McKay
R G
RG
Azrin
M A
MA
Aretz
T A
TA
Waters
D D
DD
Fram
D B
DB
D000800:Angioplasty, Balloon; D000818:Animals; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000473:pathology / Q000503:physiopathology*; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006358:Hot Temperature; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000473:pathology; D009336:Necrosis; D013552:Swine; D014661:Vasoconstriction