title: [A case of advanced hepatocellular carcinoma with portal invasion effectively treated by continuous intra-arterial chemotherapy with 5-fluorouracil].
abstract: A 79-year-old male diagnosed as advanced hepatocellular carcinoma with portal invasion was treated by continuous intra-arterial chemotherapy of 5-FU, which was continuously administered for 72 hours at a dose of 333 mg/mm/day every 2 weeks and repeated 12 times. Total dose of 5-FU was 14.4 g. Toxicity of this therapy was not recognized. Levels of AFP were reduced from 4385.6 ng/ml to 11.9 for 6 months. No tumor was recognized on CT scan at 6 months after starting this therapy, after 15 months of this therapy, the patient is alive and disease-free. Given the above results, continuous intra-arterial administration of this 5-FU therapy may be effective for patients with hepatocellular carcinoma.
authors.affiliation: Dept. of Surgical Oncology, Hiroshima University.
authors.forename: A
authors.initials: A
authors.lastname: Sawamura
authors.forename: R
authors.initials: R
authors.lastname: Kim
authors.forename: I
authors.initials: I
authors.lastname: Takashima
authors.forename: E
authors.initials: E
authors.lastname: Miyahara
authors.forename: K
authors.initials: K
authors.lastname: Aogi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Noma
authors.forename: J
authors.initials: J
authors.lastname: Hihara
authors.forename: T
authors.initials: T
authors.lastname: Toge
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D011168:Portal System / Q000473:pathology*; D019043:Vascular Neoplasms / Q000473:pathology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil