title: Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction.
abstract: Primarily, our objectives were to compare system A amino acid transporter activity in the microvillous plasma membrane (MVM) of placentas from normally grown (appropriate for gestational age, AGA) and intrauterine growth-restricted (IUGR) fetuses delivered during the third trimester, as a whole and in relation to the severity of IUGR. Ten AGA and 16 IUGR pregnancies were studied at the time of elective cesarean section performed between 28 and 40 wk of gestation. Severity of IUGR pregnancies was assessed primarily by Doppler velocimetry and fetal heart rate monitoring. Placental MVM vesicles were prepared, and system A activity in these was measured. The transporter activity was significantly lower in IUGR compared with AGA pregnancies. Within the IUGR group system A activity was only significantly lower, compared with AGA, in cases that presented with a reduction in umbilical blood flow. We conclude that placental MVM system A activity is lower in IUGR compared with AGA pregnancies delivered during the third trimester. System A activity is related to the severity of IUGR.
authors.affiliation: Department of Child Health, University of Manchester, St. Mary's Hospital, United Kingdom.
authors.forename: J D
authors.initials: JD
authors.lastname: Glazier
authors.forename: I
authors.initials: I
authors.lastname: Cetin
authors.forename: G
authors.initials: G
authors.lastname: Perugino
authors.forename: S
authors.initials: S
authors.lastname: Ronzoni
authors.forename: A M
authors.initials: AM
authors.lastname: Grey
authors.forename: D
authors.initials: D
authors.lastname: Mahendran
authors.forename: A M
authors.initials: AM
authors.lastname: Marconi
authors.forename: G
authors.initials: G
authors.lastname: Pardi
authors.forename: C P
authors.initials: CP
authors.lastname: Sibley
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D026905:Amino Acid Transport Systems; D002245:Carbon Dioxide / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D005260:Female; D005315:Fetal Diseases / Q000503:physiopathology*; D005317:Fetal Growth Retardation / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008871:Microvilli / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D009929:Organ Size; D010100:Oxygen / Q000378:metabolism; D010313:Partial Pressure; D010920:Placenta / Q000378:metabolism*; D010929:Placentation; D011247:Pregnancy; D012720:Severity of Illness Index; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism; D014469:Umbilical Arteries / Q000502:physiology; D014471:Umbilical Veins / Q000502:physiology
chemical_list: D026905:Amino Acid Transport Systems; D002352:Carrier Proteins; D017923:Sodium-Hydrogen Exchangers; D002245:Carbon Dioxide; D000469:Alkaline Phosphatase; D010100:Oxygen