Synthesis and antimicrobial screening of some novel thiazoles, dithiazoles and thiazolylpyridines.
Several thiazolines 2a-c, and 4-thiazolidinones 3a-c were synthesized through the reaction of the cyanoacetic acid hydrazide derivatives 1a-c with phenacyl bromides or chloroacetic acid, respectively. The dithiazoles 4a, b were obtained from 2a, b through their reaction with sulphur and phenyl isothiocyanate. The dithiazoles 6a, b were prepared from 4a through its reaction with dimethyl sulphate followed by reaction of the produced 2-methylthiothiazolium salt 5 with either malononitrile or ethyl cyanoacetate. The thiazolyl-pyridines 7a, b and 8a, b were obtained from 2a, b through their reaction with arylidene malonitrile and arylidene ethyl cyanoacetate, respectively. The prepared compounds were screened for their antibacterial and antifungal activities in vitro. Some of them showed weak effects.
Fahmy
H T
HT
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011725:Pyridines; D013844:Thiazoles