Infectious disease as an evolutionary paradigm.
The basic principles of genetics and evolution apply equally to human hosts and to emerging infections, in which foodborne outbreaks play an important and growing role. However, we are dealing with a very complicated coevolutionary process in which infectious agent outcomes range from mutual annihilation to mutual integration and resynthesis of a new species. In our race against microbial evolution, new molecular biology tools will help us study the past; education and a global public health perspective will help us deal better with the future.
Lederberg
J
J
Sackler Foundation Scholar, Rockefeller University, New York, New York 10021-6399, USA. Lederberg@mail.rockefeller.edu
D000818:Animals; D001419:Bacteria / Q000235:genetics; D019143:Evolution, Molecular; D014644:Genetic Variation; D006266:Health Education; D006801:Humans; D007239:Infections / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D010271:Parasites / Q000235:genetics; D014780:Viruses / Q000235:genetics