title: Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid.
abstract: Two children developed multiorgan dysfunction with disseminated intravascular coagulation 9 days after lamotrigine was added to their antiepileptic therapy, which included valproic acid. During the episodes, rhabdomyolysis was detected in one of them, while being seizure-free, suggesting that this adverse reaction may involve muscular tissue.
authors.affiliation: Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: D S
authors.initials: DS
authors.lastname: Chattergoon
authors.forename: M A
authors.initials: MA
authors.lastname: McGuigan
authors.forename: G
authors.initials: G
authors.lastname: Koren
authors.forename: P
authors.initials: P
authors.lastname: Hwang
authors.forename: S
authors.initials: S
authors.lastname: Ito
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D009102:Multiple Organ Failure / Q000139:chemically induced*; D014227:Triazines / Q000009:adverse effects*; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000077213:Lamotrigine