title: Chromosome 8 tetrasomies and pentasomies--a clonal abnormality closely associated with acute monocytic leukaemia.
abstract: We report four cases of polysomy 8 (one tetrasomy and three pentasomies) observed in acute monocytic leukemia (FAB M4 and M5). Three of them showed a rearrangement of 11q23 identified by conventional cytogenetic analysis and/or chromosome painting. Our cases as well as a review of the literature, suggest that polysomy 8 is preferentially associated with monocytic differentiation (24/31). These polysomies have been observed in 21 de novo leukemias and in 10 secondary hematological disorders. A 11q23 rearrangement has been detected in 9 out of 32 patients, by conventional cytogenetic techniques in 7 and by FISH in 2. We suggest that these cases should be analysed by FISH and molecular studies in order to detect a rearrangement of MLL/11q23. Monocytic differentiation is often associated with a change of the MLL gene and the polysomy 8 might be a particular clonal evolution secondary to 11q23 abnormality.
authors.affiliation: Laboratoire de Cytologie & Cytogénétique and Service d'Hématologie CHU, Brest, France. Michel.Lessard@Univ-brest.fr
authors.forename: M
authors.initials: M
authors.lastname: Lessard
authors.forename: A
authors.initials: A
authors.lastname: Herry
authors.forename: C
authors.initials: C
authors.lastname: Berthou
authors.forename: M C
authors.initials: MC
authors.lastname: Léglise
authors.forename: J F
authors.initials: JF
authors.lastname: Abgrall
authors.forename: I
authors.initials: I
authors.lastname: Luquet
authors.forename: N
authors.initials: N
authors.lastname: Dastugue
authors.forename: E
authors.initials: E
authors.lastname: Duchayne
authors.forename: F
authors.initials: F
authors.lastname: Rigal-Huguet
authors.forename: M
authors.initials: M
authors.lastname: Lafage
authors.forename: D
authors.initials: D
authors.lastname: Sainty
authors.forename: J
authors.initials: J
authors.lastname: Reiffers
authors.forename: P
authors.initials: P
authors.lastname: Bernard
mesh_terms: D000293:Adolescent; D000368:Aged; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged