[Immunogenetic study in Mexican couples with recurrent spontaneous abortions].
OBJECTIVE
To study the HLA markers in Mexican couples who have suffered three or more spontaneous abortions.


METHODS
The study included 24 couples with recurrent abortions and 32 with normal fertility.


METHODS
HLA class I (A, B, C) and class II (DR, DQ) typing was done with a standard microlymphocytoxity test. The intergroup differences were evaluated by chi-square and the Fisher exact test.


RESULTS
The frequency of the MHC markers in the males and females of couples with abortions were not significantly different from those in fertile couples. However, the abortion couples shared class I antigens more often than expected from random mating as compared to fertile couples, specially in the HLA-B locus. We also found a significantly decreased frequency of the HLA-B7 antigen in males belonging to the abortion group.


CONCLUSIONS
These results suggest that HLA-B antigens may be markers for genes related to pregnancy outcome in Mexicans.
Silva
B
B
Departamento de Genética, Hospital General de México, SS, México, D.F.
Yamamoto-Furusho
J K
JK
Grether
P
P
Vargas-Alarcón
G
G
Kofman
S
S
Granados
J
J
D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D005298:Fertility / Q000235:genetics / Q000276:immunology; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015793:HLA-B7 Antigen / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome
D006680:HLA Antigens; D015793:HLA-B7 Antigen