Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice.
Ampullosporin (I; Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol) was isolated from the mycelium of Sepedonium ampullosporum as a new 15-membered peptaibol-type antibiotic. The structure was determined by mass spectrometric and two-dimensional NMR experiments. Ampullosporin displays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructiva, causes hypothermia and decreased spontaneous locomotor activity in mice in dosages > 1 mg/kg.
Ritzau
M
M
Hans-Knöll-Institute of Natural Products Research, Jena, Germany.
Heinze
S
S
Dornberger
K
K
Berg
A
A
Fleck
W
W
Schlegel
B
B
Härtl
A
A
Gräfe
U
U
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi; D015394:Molecular Structure; D054848:Peptaibols; D010455:Peptides
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054848:Peptaibols; D010455:Peptides; C109004:ampullosporin