Intracameral urokinase for dissolution of fibrin or blood clots after glaucoma surgery.
OBJECTIVE
To report the use of intracameral urokinase for dissolving fibrin or blood clots after glaucoma surgery.


METHODS
Four eyes of four patients who had undergone glaucoma surgery developed an anterior chamber fibrin or blood clot and increased intraocular pressure. Urokinase was injected into the anterior chamber in each patient to dissolve the clot.


RESULTS
In all cases, urokinase injection resulted in reduction of intraocular pressure. No adverse effects of urokinase injection were detected during the short follow-up period.


CONCLUSIONS
Urokinase may be a safe, inexpensive, and convenient alternative to tissue plasminogen activator for dissolving fibrin or blood clots after glaucoma surgery. Additional studies are warranted to evaluate the long-term safety of intracameral injection.
WuDunn
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Department of Ophthalmology, Indiana University, Indianapolis 46202, USA. dwudunn@iupui.edu
D000368:Aged; D000867:Anterior Chamber / Q000187:drug effects*; D005337:Fibrin / Q000187:drug effects*; D005342:Fibrinolysis / Q000187:drug effects*; D015355:Glaucoma, Neovascular / Q000601:surgery; D006801:Humans; D006988:Hyphema / Q000188:drug therapy*; D007267:Injections; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
D005337:Fibrin; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator