A leiomyoma of the iris documented by immunohistochemistry and electron microscopy.
OBJECTIVE
To report an iris leiomyoma documented in accordance with today's stricter diagnostic criteria.


METHODS
Light microscopy, immunohistochemistry and electron microscopy were performed on the 3 mm ball-like, greyish-white vascularized tumour of the iris, close to the sphincter pupillae.


RESULTS
Light microscopy of the extirpated neoplasm showed the characteristic appearance of a leiomyoma with densely packed spindle-shaped cells, with oval nuclei and granular cytoplasm. On electron microscopic examination the tumour exhibited the characteristic features of a smooth muscle neoplasm. The immunohistochemistry was consistent with a myogenic tumour because the tumour cells were positive for smooth muscle actin and desmin, but negative for S-100 and melanin.


CONCLUSIONS
The case illustrated the necessity of performing ancillary procedures such as electron microscopy and immunohistochemistry to substantiate a correct, although rare diagnosis.
Eide
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University Eye Department, The National Hospital, Rikshospitalet, University of Oslo, Norway.
Farstad
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IN
Røger
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D000199:Actins / Q000378:metabolism; D000328:Adult; D003893:Desmin / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D015811:Iris Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure*; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008543:Melanins / Q000378:metabolism; D008854:Microscopy, Electron; D009418:S100 Proteins / Q000378:metabolism
D000199:Actins; D003893:Desmin; D008543:Melanins; D009418:S100 Proteins