title: Relationship between seminal LDH-C4 and spermatozoa with acrosome anomalies.
abstract: Lactate dehydrogenase C4 (LDH-C4), the specific isozyme of LDH produced by germ cells, was assessed in the seminal plasma of 55 patients to test a potential link between LDH-C4 and the count per ml of spermatozoa with acrosome anomalies. A simple regression curve shows a statistically significant positive correlation between seminal LDH-C4 concentrations and count per ml of spermatozoa with acrosome anomalies (r = + 0.640, P < 0.0001). No correlation was found between seminal LDH-C4 concentrations and sperm motility. Though seminal LDH-C4 thus seems to be a poor indirect marker of energy produced by spermatozoa, in contrast, this LDH isozyme may be a useful indirect marker of acrosome anomalies.
authors.affiliation: Laboratoire de Biochimie, Biologie de la Reproduction, Centre Hospitalier Général, Chartres, France.
authors.forename: A
authors.initials: A
authors.lastname: Laudat
authors.forename: P
authors.initials: P
authors.lastname: Foucault
authors.forename: A M
authors.initials: AM
authors.lastname: Palluel
mesh_terms: D000177:Acrosome / Q000201:enzymology*; D000328:Adult; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008297:Male; D012661:Semen / Q000201:enzymology*; D012680:Sensitivity and Specificity; D013081:Sperm Motility; D013094:Spermatozoa / Q000002:abnormalities* / Q000201:enzymology*
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase