title: Morphometric analysis of pediatric and nonhyperplastic prostate glands: evidence that BPH is not a unique stromal process.
abstract: BACKGROUND
  Although quantitative morphometry of benign prostatic hyperplasia (BPH) has been described, there is a paucity of information on the morphometry of the nonhyperplastic prostate. This study determines the histologic composition of prostates obtained from males, ages 2 days to 40 years, in order to provide insights into the morphometry of the "normal" gland.
  
  
  METHODS
  The histologic composition of 45 prostates was obtained from autopsies of males with age groups stratified to reflect the neonatal, childhood, peripubertal, adolescent, and young adult periods. Double immunoenzymatic staining and computer image analysis were used to determine the mean area densities of the smooth muscle (SM), connective tissue (CT), glandular epithelium (E), and lumen (L).
  
  
  RESULTS
  A progressive decrease in SM area density throughout childhood, prepuberty, and puberty was seen. The density of SM significantly increased following puberty and throughout adolescence and early adulthood. There was a concomitant increase in CT from the neonatal period throughout childhood, prepuberty, and puberty, and a decrease after puberty and throughout adolescence and early adulthood. Since the changes in SM and CT were inversely related, the percent contribution of the stromal compartment to the total gland remained constant.
  
  
  CONCLUSIONS
  The stromal to epithelial ratio remains constant from birth to age 40 in nonhyperplastic glands and is similar to the ratios in asymptomatic and symptomatic BPH tissues.
authors.affiliation: Department of Urology, New York University School of Medicine, New York 10016, USA.
authors.forename: E
authors.initials: E
authors.lastname: Shapiro
authors.forename: V
authors.initials: V
authors.lastname: Hartanto
authors.forename: E J
authors.initials: EJ
authors.lastname: Perlman
authors.forename: R
authors.initials: R
authors.lastname: Tang
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Lepor
mesh_terms: D000293:Adolescent; D000328:Adult; D001344:Autopsy; D002648:Child; D002675:Child, Preschool; D003238:Connective Tissue / Q000033:anatomy & histology / Q000473:pathology; D004848:Epithelium / Q000033:anatomy & histology / Q000473:pathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009130:Muscle, Smooth / Q000033:anatomy & histology / Q000473:pathology; D011467:Prostate / Q000033:anatomy & histology* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000473:pathology*