title: Deprenyl stimulates the release of luteinizing hormone from the pituitary in vitro.
abstract: The direct effects of deprenyl on the pituitary were investigated by measuring the release of luteinizing hormone (LH) from the pituitary glands of male Sprague-Dawley rats in vitro. Basal release of LH was determined by incubating the pituitaries in Krebs-Ringer Henseleit (KRH) solution with 0, 0.1, 1, or 10 mM of deprenyl for 1 h. In the control group, LH release was not different in pre- and posttreatment periods. In contrast, in the 10 mM group, LH release increased by 436% (p<0.01). Incubation of pituitaries with 0.1 or 1 mM deprenyl did not alter LH release. It is concluded that deprenyl a monoamine oxidase inhibitor, can also act directly on the pituitary.
authors.affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: MohanKumar
authors.forename: S M
authors.initials: SM
authors.lastname: MohanKumar
authors.forename: S K
authors.initials: SK
authors.lastname: Quadri
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D012642:Selegiline / Q000494:pharmacology*
chemical_list: D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D007986:Luteinizing Hormone