Pharmacological studies on Puerariae flos III: protective effects of kakkalide on ethanol-induced lethality and acute hepatic injury in mice.
Kakkalide, one of the major isoflavonoid components of Puerariae flos, has been investigated for its effect on ethanol-induced intoxication and on hepatic injury, including hyperglycaemia, in mice. Kakkalide reduced mortality associated with administration of ethanol. At doses of 100 and 200 mg kg-1 the effect of kakkalide was significant. The same dose of kakkalide prevented increased serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activity. At a dose of 200 mg kg-1 it also counteracted ethanol-induced elevation of glucose levels. These results suggest that kakkalide might be useful for counteracting the effects of alcohol and might be effective for treating hepatic injury.
Yamazaki
T
T
Tsukuba Research Institute, Ohta's Isan Co. Ltd., Ibaraki, Japan.
Nakajima
Y
Y
Niho
Y
Y
Hosono
T
T
Kurashige
T
T
Kinjo
J
J
Nohara
T
T
D000208:Acute Disease; D000818:Animals; D004187:Disaccharides / Q000627:therapeutic use*; D000431:Ethanol / Q000633:toxicity; D006027:Glycosides; D006943:Hyperglycemia / Q000139:chemically induced / Q000517:prevention & control; D007529:Isoflavones / Q000627:therapeutic use*; D008108:Liver Diseases, Alcoholic / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*
D004187:Disaccharides; D006027:Glycosides; D007529:Isoflavones; D010936:Plant Extracts; D000431:Ethanol; C108698:kakkalide