Simulation of cough in man by magnetic stimulation of the thoracic nerve roots.
Normal cough requires abdominal muscle contraction. We have previously reported contraction of the abdominal muscles elicited by a single percutaneous magnetic stimulation of the thoracic nerve roots. We hypothesized that paired magnetic twitches could generate sufficient tension in the abdominal muscles to simulate cough. Therefore, six normal subjects were stimulated at the T10 intervertebral level in the seated position. We measured the gastric pressure elicited by paired magnetic stimuli (pTw Pga) with interstimulus intervals in the range of 10 ms (100 Hz) to 999 ms (1 Hz). In the second part of the study we evaluated paired stimuli (at the frequency found to produce the greatest response) using a valve to simulate the function of the glottis; the valve was arranged such that it opened once mouth pressure exceeded a predetermined threshold. Mean pTw Pga during stimulation for the 6 subjects was 74 cm H2O (range, 30-109), and mean peak flow was 209 L/min (range, 128-345 L/min). These values were increased if the subject took a prior inspiration or had previously made a vigorous expiratory effort. Comparable values for a maximal natural cough were 212 cm H2O and 649 L/min. We conclude that paired magnetic thoracic nerve root stimulation produces gastric pressure and expiratory flow of an order of magnitude comparable to a natural cough.
Kyroussis
D
D
Department of Thoracic Medicine, King's College School of Medicine, London, United Kingdom.
Polkey
M I
MI
Mills
G H
GH
Hughes
P D
PD
Moxham
J
J
Green
M
M
D000009:Abdominal Muscles / Q000294:innervation / Q000503:physiopathology; D000328:Adult; D003371:Cough / Q000503:physiopathology*; D006801:Humans; D008280:Magnetics; D008297:Male; D009119:Muscle Contraction; D010812:Physical Stimulation; D011312:Pressure; D012123:Pulmonary Ventilation; D013126:Spinal Nerve Roots / Q000503:physiopathology*; D013270:Stomach / Q000503:physiopathology