Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents.
Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats. Adenosinergic agents such as adenosine (50, 100 mg/kg), 2-choloroadenosine (1, 2 mg/kg), carbamazepine (20, 80 mg/kg), N6-cyclohexyladenosine (1, 2 mg/kg) and dipyridamole (10, 20 mg/kg) produced theophylline-sensitive protective effects as they dose-dependently prolonged the latencies for onset of forelimb clonus with rearing. Pretreatment with Ro 5-4864 (20 mg/kg i.p.) did not offer any protection. These results indicate the possible involvement of adenosinergic mechanism in preventing lithium-pilocarpine-induced SE and mortality.
George
B
B
Pharmacology Division, Panjab University, Chandigarh, India.
Kulkarni
S K
SK
D015762:2-Chloroadenosine / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D002220:Carbamazepine / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008094:Lithium / Q000008:administration & dosage*; D008297:Male; D010862:Pilocarpine / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality; D013806:Theophylline / Q000494:pharmacology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology
D000927:Anticonvulsants; D014665:Vasodilator Agents; D010862:Pilocarpine; D015762:2-Chloroadenosine; D002220:Carbamazepine; C027513:N(6)-cyclohexyladenosine; D004176:Dipyridamole; D008094:Lithium; D013806:Theophylline; D000241:Adenosine