title: Turning down the heat: new routes to inhibition of inflammatory signaling by prostaglandin H2 synthases.
abstract: Many nonsteroidal anti-inflammatory drugs act by inhibiting the cyclooxygenase activity of prostaglandin H2 synthase (PGHS), a key enzyme in the biosynthesis of prostaglandins. Gastric toxicity remains a serious problem with the current drugs, however. Recent advances in the understanding of PGHS now suggest two possible approaches to producing drugs with fewer side effects.
authors.affiliation: R.W. Johnson Pharmaceutical Research Institute, Don Mills, Ontario, Canada.
authors.forename: D G
authors.initials: DG
authors.lastname: Munroe
authors.forename: C Y
authors.initials: CY
authors.lastname: Lau
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011451:Prostaglandin-Endoperoxide Synthases