Radiation-associated synovial sarcoma.
We describe a case of synovial sarcoma occurring in a 36 year-old woman, 8 years after radiation therapy for Hodgkin's disease. The tumor showed histological, immunohistochemical, ultrastructural, and molecular features diagnostic of synovial sarcoma. To our knowledge, this is the first report of a fully documented case of radiation associated synovial sarcoma.
van de Rijn
M
M
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, 19104, USA.
Barr
F G
FG
Xiong
Q B
QB
Salhany
K E
KE
Fraker
D L
DL
Fisher
C
C
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008854:Microscopy, Electron; D018396:Mucin-1 / Q000032:analysis; D009381:Neoplasms, Radiation-Induced / Q000737:chemistry / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000648:ultrastructure; D010524:Peripheral Nervous System Neoplasms / Q000737:chemistry / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000648:ultrastructure; D013584:Sarcoma, Synovial / Q000737:chemistry / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000648:ultrastructure; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor; D018396:Mucin-1; D007633:Keratins