title: [The history of healing; beriberi: 'kind of paralysis'].
abstract: Beriberi began to attract increasing attention in the second half of the 19th century, mostly due to the large numbers of victims among Dutch military personnel in the Netherlands East Indies. A study, carried out in Atjeh in 1886 by the Japanese Sugenoya and F. J. Cornelissen, led to the conclusion that there existed a beriberi bacillus which they could make visible in stained microscopical preparations. An extensive disinfection campaign in all barracks followed, but its benefits were a matter of debate. Inadequate nutrition in the investigators' eyes was only a predisposing factor. A.G. Vorderman (1844-1902) assumed a connection between rice feeding and beriberi in prisoners; he reported that the disease coincided with a diet of polished white rice. Beriberi could be prevented by providing the prisoners with 'red rice' (unpolished rice). However, red rice was regarded as inferior and status-lowering so that substitution of red for white rice in the rations was impossible. The concept of a 'lacking substance' (thiamine, vitamin B1) was hesitatingly accepted in the Netherlands. C. Winkler and C. Eijkman, for instance, refused until the early twenties of this century to exclude the possibility of a bacterial infection as the cause. As known, Eijkman in 1929 was awarded the Nobel prize for his contribution to vitamin research.
authors.affiliation: Vrije Universiteit, Faculteit der Geneeskunde, vakgroep Metamedica, Amsterdam.
authors.forename: A
authors.initials: A
authors.lastname: de Knecht-van Eekelen
mesh_terms: D000818:Animals; D001602:Beriberi / Q000175:diagnosis / Q000178:diet therapy / Q000266:history*; D006224:Cricetinae; D049672:History, 19th Century; D006801:Humans