[Effects of xueguantong on plasma endothelin and calcitonin gene-related peptide in quail atherosis model].
This paper mainly reported the antiatherogenic mechanism of action of Xueguantong on molecular level. After being established by feeding with high fat diet for 12 weeks, the quail atherosis models were given Xueguantong for 30 days. Then, determining their plasma endothelin and calcitonin gene-related peptide (CGRP) with radioimmunoassay (RIA) and observing the effects of Xueguantong on plasma endothelin and CGRP in quail atherosis models. Results showed that the plasma endothelin increased and CGRP decreased during quail atherosis formation. The plasma endothelin was decreased (P < 0.05) and CGRP was increased (P < 0.05) by using Xueguantong. It suggested that one of antiatherogenic mechanisms of Xueguantong was decreasing the endothelin and increasing the CGRP.
Zhou
Y W
YW
Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing.
Wang
M
M
Ge
Z Y
ZY
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003370:Coturnix; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016232:Endothelins / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood
D004365:Drugs, Chinese Herbal; D016232:Endothelins; D014280:Triglycerides; D002784:Cholesterol; D015740:Calcitonin Gene-Related Peptide