[Estimation of safety and toxicity of rho-nitrophenol sodium with a physiologically based pharmacokinetics model].
The safety and toxicity of chemicals given first to animals and finally to humans are generally estimated with a method of safe coefficient, which lacks scientific ground. To change the traditional method, we designed a physiologically based pharmacokinetics model (PBPK) for the estimation of safety and toxicity of chemicals. For example, rho-nitrophenol sodium (PNP-Na) was used. The PNP-Na pharmacokinetics in bodies of rat as well as humans were studied, and possibilities of making use of the model in the estimation of safety and toxicity of chemicals were also discussed.
Gao
Q
Q
Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo.
Kurihara
N
N
Yanagisawa
H
H
Wada
O
O
D000818:Animals; D006801:Humans; D008954:Models, Biological; D009596:Nitrophenols / Q000493:pharmacokinetics* / Q000633:toxicity; D051381:Rats
D009596:Nitrophenols; C024836:4-nitrophenol