[Effects of ginkgo plus on hypoxic pulmonary hypertension in rats].
We examined the effects of Ginkgo Plus on the pulmonary hemodynamics and right ventricular hypertrophy in rats exposed to isobaric chronic hypoxia. The rats treated with chronic hypoxia developed pulmonary hypertension and right ventricular hypertrophy. Ginkgo Plus reduced significantly the hypoxia-induced increase of mean pulmonary arterial pressure and pulmonary vascular resistance as well as the ratio of right ventricular weight vs left ventricular plus septal weights. The results suggested that Ginkgo Plus could relieve the hypoxic pulmonary hypertension.
Cheng
D
D
Department of Internal Medicine, First Affiliated Hospital, Chengdu.
Chen
W
W
Yang
X
X
Xiao
X
X
Xu
D
D
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006976:Hypertension, Pulmonary / Q000503:physiopathology* / Q000517:prevention & control; D017380:Hypertrophy, Right Ventricular / Q000503:physiopathology* / Q000517:prevention & control; D000860:Hypoxia / Q000150:complications; D008297:Male; D011651:Pulmonary Artery / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014655:Vascular Resistance / Q000187:drug effects
D004365:Drugs, Chinese Herbal