Intraerythrocytic 2,3-diphosphoglycerate concentration in hypertensive subjects before and following control by anti hypertensive treatment.
METHODS
We measured the 2,3-diphosphoglycerate inraerythrocytic concentration in 24 normal controls and in 24 hypertensives before and following drug therapy.


RESULTS
In hypertensives the 2,3-diphosphoglycerate concentration was higher than that of the controls (14.96 mumol/g Hb vs 13.26 mumol/g Hb respectively); the difference is statistically significant (p < 0.001). Following control of the hypertension by drug therapy, the 2,3 DPG levels in the patients studied do not seem to differ statistically from those of the controls.


CONCLUSIONS
This may be a consequence of lower cardiac output in hypertension which results to a lower tissue perfusion, leading to an increased concentration of deoxygenated haemoglobin in the vein blood. Measurement of 2,3-diphosphoglucerate may prove of value in estimating tissue perfusion in hypertension.
Kasparian
H
H
First Department of Medicine, Athens University Medical School, Greece.
Konstantopoulos
K
K
Tassiopoulos
S
S
Papadogiannis
D
D
Karadzas
N
N
Tassiopoulos
T
T
D019794:2,3-Diphosphoglycerate / Q000097:blood*; D000328:Adult; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy*; D008875:Middle Aged
D019794:2,3-Diphosphoglycerate