Synthesis and antimicrobial activity of new 1-benzylbenzimidazolium chlorides.
1-Benzylbenzimidazole reacts with chloromethylalkyl ethers or sulfides or chloromethylcycloalkyl ethers to produce 3-alkoxymethyl-1-benzylbenzimidazolium or 3-alkylthiomethyl-1-benzylbenzimidazolium or 1-benzyl-3-cycloalkoxymethylbenzimidazolium chlorides in very good yields. All the 1-benzylbenimidazolium chlorides showed antimicrobial activity. The relationship between chemical structure and antimicrobial activity was analyzed by quantitative structure-activity relationships (QSAR).
Pernak
J
J
Poznań University of Technology, Poland.
Arndt
A
A
Brycki
B
B
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002712:Chlorides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D001562:Benzimidazoles; D002712:Chlorides