title: [Squamous carcinoma of the esophagus with extensive pagetoid dissemination].
abstract: A case of squamous carcinoma of the esophagus with pagetoid spreading in a 59-year-old male in presented. Signs of glandular differentiation (PAS-diastase, Alcian blue) and CEA were negative in the Paget-like cells. Pagetoid spreading of squamous carcinoma and true Paget's disease are very similar histologically and very rare in the esophagus (only 6 cases reported) and they must be differentiated from each other. Paget's disease demonstrates glandular differentiation and the cells are CEA positive. The absence of glandular differentiation in the Paget-like cells of pagetoid spreading versus Paget's disease may be a good criteria to differentiate these diseases.
authors.affiliation: Servicio de Anatomía Patológica, Hospital de León.
authors.forename: D
authors.initials: D
authors.lastname: Suárez Vilela
authors.forename: F
authors.initials: F
authors.lastname: Izquierdo García
authors.forename: N
authors.initials: N
authors.lastname: Alonso Orcajo
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002299:Cardia / Q000473:pathology; D003937:Diagnosis, Differential; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004947:Esophagus / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010145:Paget Disease, Extramammary / Q000175:diagnosis*