title: Comparative studies of ivermectin and moxidectin in the control of naturally acquired cyathostome infections in horses.
abstract: The control of naturally acquired cyathostome infections in horses by treatments with ivermectin and moxidectin was evaluated in three field studies. In a first study the efficacy of both drugs was assessed in a faecal egg count reduction test. Both ivermectin and moxidectin demonstrated efficacies greater than 99 per cent for up to 60 days after treatment. In a second study, the period required for strongyle eggs to reappear was estimated in horses treated either with ivermectin or moxidectin. For the horses treated with ivermectin the period varied between 10 and approximately 13 weeks, and for moxidectin between 22 and approximately 24 weeks. With both drugs strongyle eggs started to reappear in the faeces significantly earlier in foals and young horses than in adults. In a third study, two prophylactic dosing schemes involving three ivermectin treatments at intervals of eight weeks, and two moxidectin treatments 12 weeks apart, were found to be highly effective in controlling strongyle infections of horses on pasture.
authors.affiliation: Department of Parasitology, University of Gent, Merelheke, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Demeulenaere
authors.forename: J
authors.initials: J
authors.lastname: Vercruysse
authors.forename: P
authors.initials: P
authors.lastname: Dorny
authors.forename: E
authors.initials: E
authors.lastname: Claerebout
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005260:Female; D006736:Horses; D007559:Ivermectin / Q000627:therapeutic use*; D018942:Macrolides / Q000627:therapeutic use; D008297:Male; D010270:Parasite Egg Count; D013319:Strongyle Infections, Equine / Q000188:drug therapy*; D013320:Strongyloidea
chemical_list: D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D018942:Macrolides; D007559:Ivermectin; C027837:moxidectin