title: HIV infection increases the risk of squamous intra-epithelial lesions in women with HPV infection: an analysis of HPV genotypes. DIANAIDS Collaborative Study Group.
abstract: We assessed the association between different HPV genotypes, HIV infection, and cervical squamous intra-epithelial lesions (SIL) in 236 women with known HIV serostatus enrolled in a longitudinal multicentric study in Italy. Of these women, 135 were HIV-infected, and were not markedly different from HIV-negative women with regard to demographic characteristics, sexual practices, smoking, or intravenous drug use. We obtained 232 cervical smears suitable for cytological examination and HPV-genotype analysis (134 from HIV-positive women and 98 from HIV-negative women). For 86 HIV-positive and 89 HIV-negative women, the smears appeared normal at cytomorphological analysis. Cytological dysplasia of varying degrees was detected in 48 smears from HIV-positive women and in 9 from HIV-negative women. HPV prevalence, assessed using polymerase-chain-reaction analysis, did not significantly differ between HIV-positive and HIV-negative women. The prevalence of HPV-associated SIL was much greater among HIV-infected women. The most frequently detected genotypes in both groups were HPV 16 and HPV 18. The prevalence of HPV 16 among HIV-positive women was similar to that for HIV-negative women; this was also true for HPV 18. However, in the HIV-positive group, most of these genotypes were associated with SIL. HIV-positive women showed a wider spectrum of genotypes, including non-oncogenic and rare types. An association between SIL and HIV infection was confirmed for all HPV genotype classes.
authors.affiliation: Virology Centre, S. Camillo Hospital, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cappiello
authors.forename: A R
authors.initials: AR
authors.lastname: Garbuglia
authors.forename: R
authors.initials: R
authors.lastname: Salvi
authors.forename: G
authors.initials: G
authors.lastname: Rezza
authors.forename: M
authors.initials: M
authors.lastname: Giuliani
authors.forename: P
authors.initials: P
authors.lastname: Pezzotti
authors.forename: B
authors.initials: B
authors.lastname: Suligoi
authors.forename: M
authors.initials: M
authors.lastname: Branca
authors.forename: G
authors.initials: G
authors.lastname: Migliore
authors.forename: D
authors.initials: D
authors.lastname: Formigoni Pomponi
authors.forename: C
authors.initials: C
authors.lastname: D'Ubaldo
authors.forename: G
authors.initials: G
authors.lastname: Ippolito
authors.forename: G
authors.initials: G
authors.lastname: Giacomini
authors.forename: A
authors.initials: A
authors.lastname: Benedetto
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007558:Italy; D008137:Longitudinal Studies; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D015819:Substance Abuse, Intravenous; D014412:Tumor Virus Infections / Q000150:complications* / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology; D014626:Vaginal Smears