Preparation, antimicrobial evaluation, and mutagenicity of [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols , [5-tert-butyl-2-methylaminophenyl]-[1-methyl-5-nitro-1H-2-imidazo lyl]me thanol, and [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl] ketones.
Efficient preparations of the titled compounds are described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are nonmutagenic and present a MIC as low as some of the usual standards in the field.
Arredondo
Y
Y
Department of Chemistry, Universitat Autònoma de Barcelona, Spain.
Moreno-Mañas
M
M
Pleixats
R
R
Palacín
C
C
Raga
M M
MM
Castelló
J M
JM
Ortiz
J A
JA
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology*; D000432:Methanol / Q000031:analogs & derivatives*; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D007659:Ketones; D009593:Nitroimidazoles; D000432:Methanol