Effects of a thromboxane A2 receptor antagonist in an animal model of inflammatory bowel disease.
OBJECTIVE
We evaluated the effects of an antagonist of the thromboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bowel disease (IBD).


METHODS
Colitis was induced by intracolonic instillation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ONO-NT-126 or vehicle alone was administered intraluminally via anus once a day. The rats were killed after 7 days for assessment of colonic damage by the colonic damage score.


CONCLUSIONS
ONO-NT-126 markedly reduced the colonic damage. Our findings suggest that the thromboxane-thromboxane receptor system plays an important role in this model of IBD and that antagonism of the thromboxane A2 receptor may prove useful for the treatment of IBD.
Taniguchi
T
T
Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan.
Tsukada
H
H
Nakamura
H
H
Kodama
M
M
Fukuda
K
K
Tominaga
M
M
Seino
Y
Y
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D003092:Colitis / Q000139:chemically induced / Q000517:prevention & control*; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000627:therapeutic use*; D007975:Leukotriene B4 / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017482:Receptors, Thromboxane / Q000037:antagonists & inhibitors*; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014302:Trinitrobenzenesulfonic Acid
D001643:Bridged Bicyclo Compounds; D005229:Fatty Acids, Monounsaturated; D017482:Receptors, Thromboxane; C067520:ONO-NT 126; D007975:Leukotriene B4; D000431:Ethanol; D013928:Thromboxane A2; D014302:Trinitrobenzenesulfonic Acid