Prevalence of carcinoma in situ of the testis in 207 oligozoospermic men from infertile couples: prospective study of testicular biopsies.
OBJECTIVE
To investigate the prevalence of carcinoma in situ of the testis in a group of oligozoospermic men from infertile couples.


METHODS
A consecutive group of oligozoospermic men from infertile couples were offered bilateral testicular biopsy. The observed prevalence of carcinoma in situ was compared with the expected prevalence of testicular cancer in a corresponding age matched population of Danish men, assuming all untreated cases of carcinoma in situ progress to tumour stage. This calculation was based on data from the Danish Cancer Registry.


METHODS
207 men aged 18-50 years who had sperm density below 10 million/ml in two samples within the previous 2 years or sperm density below 20 million/ml in two samples within the previous 2 years and a history of cryptorchidism or one or two atrophic testicles (orchidometer volume less than 15 cm3), or both.


METHODS
Bilateral testicular biopsies.


METHODS
Carcinoma in situ in the biopsy specimen.


RESULTS
No case of carcinoma in situ was found among the 207 men. The expected number in a normal age matched population of corresponding size was 0.8.


CONCLUSIONS
There is no increase in risk of carcinoma in situ of the testis in moderately oligozoospermic men of couples referred because of infertility.
Giwercman
A
A
Universtiy Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
Thomsen
J K
JK
Hertz
J
J
Berthelsen
J G
JG
Jensen
V
V
Meinecke
B
B
Thormann
L
L
Storm
H H
HH
Skakkebaek
N E
NE
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000473:pathology; D003718:Denmark / Q000453:epidemiology; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000453:epidemiology / Q000473:pathology; D015995:Prevalence; D011446:Prospective Studies; D013736:Testicular Neoplasms / Q000453:epidemiology* / Q000473:pathology