Recovery from metabolic bone disease in a girl with vitamin D deficiency rickets associated with primary hyperparathyroidism.
We describe a 13 year-old Ethiopian girl with vitamin D deficiency rickets. Hypercalcemia, increased serum alkaline phosphatase and PTH levels, together with low serum levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D suggested the co-existence of primary hyperparathyroidism. The surgical removal of a parathyroid adenoma led to bone healing and normalization of blood chemistry. We conclude that vitamin D deficiency masked the hyperparathyroidism and hypercalcemia, while excess PTH secretion delayed the cure of rickets until successful parathyroidectomy had been carried out.
Luboshitzky
R
R
Endocrine Institute, Central Emek Hospital, Afula, Israel.
Hardoff
R
R
D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000627:therapeutic use; D004872:Ergocalciferols / Q000627:therapeutic use; D005002:Ethiopia; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000175:diagnosis; D006961:Hyperparathyroidism / Q000150:complications* / Q000175:diagnosis; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D016105:Parathyroidectomy; D012279:Rickets / Q000175:diagnosis / Q000209:etiology*; D014808:Vitamin D Deficiency / Q000150:complications* / Q000175:diagnosis
D004872:Ergocalciferols; D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase; D002118:Calcium