Daily energy requirements in heart failure patients.
Diminished body cell mass in heart failure patients contributes to poor prognosis and decreased quality of life. The level of daily energy intake needed to maintain body cell mass and optimal physiological function in heart failure patients is unknown. Thus, we examined daily energy expenditure in free-living heart failure patients to estimate daily energy requirements. Daily energy expenditure (doubly labeled water) and its components (resting and physical activity energy expenditures) were measured in 26 heart failure patients (25 men and one woman aged 69 +/- 7 years) and 50 healthy controls (48 men and two women aged 69 +/- 6 years). Resting energy expenditure was measured by indirect calorimetry; physical activity energy expenditure from the difference between daily and resting energy expenditure; body composition by dual-energy x-ray absorptiometry; leisure time physical activity from a questionnaire; and peak oxygen consumption ([peak VO2] n = 16 heart failure patients) from a treadmill test to exhaustion. Plasma markers of nutritional status were also considered. Daily energy expenditure was 17% lower (2,110 +/- 500 v 2,543 +/- 449 kcal/d) and physical activity energy expenditure 54% lower (333 +/- 345 v 728 +/- 374 kcal/d) in heart failure patients compared with healthy controls. Daily energy expenditure was related to physical activity energy expenditure (r = .79, P < .01), resting energy expenditure (r = .63, P < .01), leisure time physical activity (r = .63, P < .01), and peak VO2 (r = .58, P < .01) in heart failure patients. Stepwise regression analysis showed that daily energy requirements in heart failure patients were best estimated by a combination of resting energy expenditure and reported leisure time physical activity (total R2 = 61%; standard error of the estimate, +/- 333 kcal/d). Daily energy requirements predicted from equations derived in healthy elderly were inaccurate when applied to heart failure patients, deviating -10% to +30% from measured daily energy expenditure. We conclude that despite low levels of activity, markers of physical activity predicted daily energy needs in heart failure patients. We provide a new equation to estimate energy needs in free-living heart failure patients based on measurements of daily energy expenditure.
Toth
M J
MJ
Department of Medicine, University of Maryland, Baltimore, USA.
Gottlieb
S S
SS
Fisher
M L
ML
Poehlman
E T
ET
D015502:Absorptiometry, Photon; D002153:Calorimetry, Indirect; D015331:Cohort Studies; D017666:Deuterium Oxide; D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D015444:Exercise / Q000502:physiology; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D012016:Reference Values; D012044:Regression Analysis
D017666:Deuterium Oxide