title: DTPA aerosol in ventilation/perfusion scintigraphy for diagnosing pulmonary embolism.
abstract: The use of lung scintigraphy in evaluating suspected pulmonary embolism (PE) is controversial. Several diagnostic methods have been described for lung scans, of which the most widely applied uses 99mTc-MAA for perfusion, 133Xe for ventilation and PIOPED diagnostic criteria. This study evaluates the accuracy of lung scintigraphy using an alternative ventilation agent, 99mTc-diethylenetriamine pentacetic acid (DTPA) aerosol, and specific criteria.
  
  
  METHODS
  Diagnostic criteria for DTPA aerosol ventilation were prospectively applied to 5017 patients over a 9-yr period. Lung scan interpretations were analyzed for frequency of occurrence, and results were compared to those of angiography in 455 patients.
  
  
  RESULTS
  Scans were interpreted as normal, low or high probability in 79% of patients and as either indeterminate or medium probability in 21% of patients. Three patients had normal scans and negative angiography. In patients with low-probability scans, 111 angiograms were performed: 103 (93%) were negative, and 8 (7%) were positive. In patients with indeterminate scans, 114 angiograms were performed: 85 (75%) were negative, and 29 (25%) were positive. In patients with medium-probability scans, 149 angiograms were performed: 86 (58%) were negative, and 63 (42%) were positive. In patients with high-probability scans, 78 angiograms were performed: 6 (8%) were negative, and 72 (92%) were positive.
  
  
  CONCLUSIONS
  These results indicate that lung scintigraphy using DTPA aerosol and our criteria is accurate in diagnosing and stratifying risk of pulmonary embolic disease. Compared with 133Xe and PIOPED criteria, DTPA ventilation and our criteria reduced the false-negative rate in low-probability scans (7% versus 16%, p < 0.005) and decreased the fraction of intermediate-probability scans (21 % versus 39%, p < 0.01).
authors.affiliation: Division of Nuclear Medicine, University of Colorado Health Sciences Center, Denver 80226, USA.
authors.forename: N P
authors.initials: NP
authors.lastname: Trujillo
authors.forename: J P
authors.initials: JP
authors.lastname: Pratt
authors.forename: S
authors.initials: S
authors.lastname: Talusani
authors.forename: R A
authors.initials: RA
authors.lastname: Quaife
authors.forename: D
authors.initials: D
authors.lastname: Kumpe
authors.forename: J L
authors.initials: JL
authors.lastname: Lear
mesh_terms: D000336:Aerosols; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging* / Q000453:epidemiology; D011859:Radiography; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D014692:Ventilation-Perfusion Ratio; D014980:Xenon Radioisotopes
chemical_list: D000336:Aerosols; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; D014980:Xenon Radioisotopes; D016284:Technetium Tc 99m Pentetate