Acute ischemic stroke therapy. A clinical overview.
Acute ischemic stroke therapy has two basic therapies, dissolving the intravascular occlusion by thrombolytic therapy and protecting the brain from the harmfull cellular, and metabolic consequences ofischemic injury by neuroprotective therapy. It seems most likely that the methods that will be used to treat the acute ischemic stroke patient will be multiple, likely a combination of thrombolytic therapy for early reperfusion and neuroprotective therapy for maintaining vitality. In the last decade, a number of advances in the field of imaging and pharmacology have been made which should provide meaningful improvement for the management of acute ischemic stroke patients in the near future. This update summarizes recent clinical trials and emphasizes the question of risk versus benefit for the acute ischemic stroke therapies being developed.
Onal
M Z
MZ
Department of Neurology, Akdeniz Universitesi Araştirma Hastahanesi, Antalya, Turkey. onal@med.akdeniz.edu.tr
Fisher
M
M
D000208:Acute Disease; D002545:Brain Ischemia / Q000188:drug therapy / Q000628:therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D004359:Drug Therapy, Combination; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D015912:Thrombolytic Therapy / Q000379:methods / Q000592:standards / Q000639:trends*; D013997:Time Factors
D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents