[Clinical and experimental study of danfukang granule in treating cholecystitis and cholelithiasis].
In order to evaluate the clinical effect of Danfukang Granule (DFKG) in treating cholecystitis and cholelithiasis, 200 patients were treated with DFKG and observed with ultrasonography before and after treatment. Results showed 48 cases (24%) among the 200 patients were cured, 76 (38%) were marked effective, 70(35%) were improved and 6 (3%) ineffective, the effective rate being 97%. The lithagogue rate of cholelithiasis patients with diameter of gallstone < 0.5 cm, or those with sandy stone was 62%. In 50 post-operative patients received DFKG treatment, 28 (56%) were cured, 18 (36%) marked effective, 2 (4%) improved and 2 (4%) were ineffective, the total effective rate being 96%, while in the other 50 cases did not receive DFKG, the numbers were 8 (16%), 12(24%), 15 (30%), 15 (30%) and 70% respectively. The difference of total effective rate between the two groups were significant (analyzed by chi 2 test, P < 0.05). Experimental study-showed that the flow of hepatic bile in experimental group of guinea-pig was 3.7 +/- 0.4 ml/h, which was significantly higher than that of control group (2.7 +/- 0.1 ml/h), P < 0.05. The bile stone formation rate in experimental group was 32.4%, which was markedly lower than that of control group (93.8%), P < 0.01, suggesting the bile stone formed in experimental guinea-pigs could be evacuated by the rinsing effect of DFKG.
Niu
S K
SK
First Affiliated Hospital of Shanxi Medical College, Taiyuan.
Wang
J T
JT
Li
Z Z
ZZ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D002764:Cholecystitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002769:Cholelithiasis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D014463:Ultrasonography
D002756:Cholagogues and Choleretics; D004365:Drugs, Chinese Herbal