Activity of liver proteases in experimental methanol intoxication.
Intoxication of rats with methanol (1.5 and 3.0 g/kg body weight) led to a significant, time- and dose-dependent decrease in the activities of cathepsins A, B and C, while the activity of cathepsin D was unaffected. The decrease was associated with a different partial release of individual cathepsins to the post-lysosomal fraction.
Skrzydlewska
E
E
Department of Instrumental Analysis, Medical Academy, Białystok, Poland.
Skrzydlewski
Z
Z
Worowski
K
K
D000818:Animals; D002403:Cathepsins / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D010450:Endopeptidases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D000432:Methanol / Q000506:poisoning*; D051381:Rats; D017208:Rats, Wistar
D002403:Cathepsins; D010450:Endopeptidases; D000432:Methanol