[The effect of anisodamine hydrochloride on globin chain synthesis in anemic mice].
We treated anemic mice with Anisodamine hydrochloride followed by Hb electrophoresis and detection of globin chain synthesis rate. We found that the synthesis of their globin chains remarkably increased and would last for approximately 10 days, While the results did not show any generation of fetal Hb, possible effect of the drug might come from the raising of alpha and beta globin chains of the adult mice.
Yang
K
K
Institute of Basic Medical Sciences, CAMS, Beijing.
Kang
W
W
Liang
C
C
D000740:Anemia / Q000378:metabolism*; D000818:Animals; D005914:Globins / Q000096:biosynthesis*; D051379:Mice; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D017086:beta-Thalassemia / Q000378:metabolism
D012991:Solanaceous Alkaloids; C003922:anisodamine; D005914:Globins