[The effect of the glycoside strophanthin K on the ultrastructure of the cardiomyocytes in the pro-oxidant zone of the myocardium in rats with experimental heart failure].
The effect of the cardiotonic strophanthin K on the ultrastructure of cardiomyocytes in the "pro-oxidant zone" in hypercatecholemia was studied in Wistar rats with experimental cardiac insufficiency (ECI). In ECI two differently directed processes, compensatory and degenerative, develop in the "pro-oxidant zone". After administration of strophanthin K the degenerative processes in the "pro-oxidant zone" increased: the number of degenerated cardiomyocytes was 41.9 +/- 1.4% in ECI and 85.35 +/- 3.4% after strophanthin administration (p > 0.99).
Chernysh
I N
IN
Sadovnikov
V B
VB
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D006321:Heart / Q000187:drug effects*; D006333:Heart Failure / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D013328:Strophanthins / Q000494:pharmacology* / Q000627:therapeutic use
D002316:Cardiotonic Agents; D013328:Strophanthins; C029082:strophanthin K