title: [Hypercholesteremia and hyperfibrinogenemia in sudden deafness].
abstract: BACKGROUND
  The pathogenesis of sudden hearing loss has not been elucidated as yet. Insufficient perfusion of the cochlea due to an increased blood viscosity, microthrombosis, or altered vasomotion are assumed. Hypercholesterolemia and hyperfibrinogenemia are frequently observed in patients with sudden sensorineural hearing loss. The aim of this study was to investigate the incidence of hypercholesterolemia and hyperfibrinogenemia in patients suffering from sudden hearing loss compared to normal controls. In an intervention study the impact of drastic lowering of plasma cholesterol and fibrinogen by a selective extracorporal apheresis was studied.
  
  
  METHODS
  In a case-control study of 23 patients suffering from sudden hearing loss, plasma cholesterol and fibrinogen levels as well as erythrocyte aggregation and plasma viscosity were determined. Seven sudden hearing loss patients from this group were treated with H.E.L.P. apheresis, an extracorporal procedure removing fibrinogen and idl-cholesterol from plasma.
  
  
  RESULTS
  Plasma fibrinogen and cholesterol levels were higher in sudden hearing loss patients, leading to significantly elevated values of erythrocyte aggregation and plasmaviscosity. Six out of the seven patients treated with a single H.E.L.P. apheresis immediately showed an improvement of auditory thresholds.
  
  
  CONCLUSIONS
  We conclude that hyperfibrinogenemia and hypercholesterolemia may contribute to the clinical event of sudden hearing loss. Our study shows for the first time that acute and drastic removal of plasma fibrinogen and low density lipoproteins can be an effective clinical tool in the treatment of patients with sudden hearing loss.
authors.affiliation: Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke, Ludwig-Maximilians-Universität München.
authors.forename: M
authors.initials: M
authors.lastname: Suckfüll
authors.forename: J
authors.initials: J
authors.lastname: Thiery
authors.forename: C
authors.initials: C
authors.lastname: Wimmer
authors.forename: K
authors.initials: K
authors.lastname: Mees
authors.forename: K
authors.initials: K
authors.lastname: Schorn
mesh_terms: D000328:Adult; D000368:Aged; D001309:Auditory Threshold / Q000502:physiology; D001809:Blood Viscosity / Q000502:physiology; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D003051:Cochlea / Q000098:blood supply; D004903:Erythrocyte Aggregation / Q000502:physiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D003639:Hearing Loss, Sudden / Q000097:blood / Q000209:etiology* / Q000628:therapy; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D016896:Treatment Outcome
chemical_list: D008078:Cholesterol, LDL; D005340:Fibrinogen