title: Nephrotic syndrome after liver transplantation in a patient with hepatitis C virus-associated glomerulonephritis.
abstract: In recent years, hepatitis C virus infection has been reported to be typically associated with membranoproliferative glomerulonephritis and less frequently with membranous nephropathy. Treatment of hepatitis C with interferon-alpha can reduce viremia and improve renal disease. After liver transplantation for hepatitis C virus-associated liver failure, standard immunosuppressive protocols result in a significant increase in hepatitis C viremia. In this report we describe a patient with end-stage liver disease and biopsy-proven hepatitis C-associated glomerulonephritis who underwent liver transplantation. Within 1 month after transplantation, he developed a severe nephrotic syndrome that paralleled a marked increase in viremia. We discuss the possible pathogenic relationship between hepatitis C virus infection and the nephrotic syndrome that followed liver transplantation.
authors.affiliation: Transplantation Unit, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: M
authors.initials: M
authors.lastname: Pascual
authors.forename: R
authors.initials: R
authors.lastname: Thadhani
authors.forename: R T
authors.initials: RT
authors.lastname: Chung
authors.forename: W W
authors.initials: WW
authors.lastname: Williams
authors.forename: S
authors.initials: S
authors.lastname: Meehan
authors.forename: N
authors.initials: N
authors.lastname: Tolkoff-Rubin
authors.forename: R
authors.initials: R
authors.lastname: Colvin
authors.forename: A B
authors.initials: AB
authors.lastname: Cosimi
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000821:virology; D016174:Hepacivirus / Q000302:isolation & purification; D006526:Hepatitis C / Q000150:complications* / Q000601:surgery / Q000628:therapy; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation / Q000502:physiology; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology*; D011183:Postoperative Complications; D011507:Proteinuria; D012367:RNA, Viral / Q000097:blood; D012086:Reoperation; D013997:Time Factors; D014766:Viremia / Q000150:complications*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D012367:RNA, Viral; D004656:Enalapril; D003404:Creatinine