title: [Dynamic computerized tomography of the bone marrow of normal and pathologic vertebrae].
abstract: OBJECTIVE
  The contrast medium dynamics of normal and abnormal bone marrow was examined by CT.
  
  
  METHODS
  Standardised sections of lumbar vertebrae were obtained after intravenous injection of 80 ml Ultravist 370 and time-density curves of the marrow spaces were calculated in 38 patients.
  
  
  RESULTS
  Time-density curves of patients with normal bone marrow differed significantly from those with proliferative bone marrow diseases in respect of maximal density and uptake at 120 and 240 seconds. Patients treated by radiation showed reduced uptake.
  
  
  CONCLUSIONS
  Variations in the time-density curves between normal and abnormal bone marrow provided evidence of different perfusion and uptake of the contrast medium in the extracellular space of the bone marrow. Further investigation will be necessary to determine whether dynamic CT is able to document the effect of radiotherapy or chemotherapy on malignant bone marrow infiltration.
authors.affiliation: Strahlenklinik und Poliklinik im Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin.
authors.forename: C
authors.initials: C
authors.lastname: Stroszczynski
authors.forename: N
authors.initials: N
authors.lastname: Hosten
authors.forename: H
authors.initials: H
authors.lastname: Amthauer
authors.forename: J
authors.initials: J
authors.lastname: Ricke
authors.forename: T
authors.initials: T
authors.lastname: Ehrenstein
authors.forename: H
authors.initials: H
authors.lastname: Schedel
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D001855:Bone Marrow Diseases / Q000000981:diagnostic imaging*; D019046:Bone Marrow Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D003287:Contrast Media / Q000008:administration & dosage; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008223:Lymphoma / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide