Epithelial cell growth and differentiation. V. Transcriptional regulation, development, and neoplasia of the intestinal epithelium.
Coordination of gene transcription is a critical regulatory step in orchestrating developmental, differentiation, and adaptation processes in the mammalian intestinal epithelium. An understanding of the regulatory network of nuclear proteins that direct transcriptional initiation of intestinal genes will provide insight into the mechanisms of normal development and differentiation as well as disease processes such as neoplasia.
Traber
P G
PG
Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA.
D000818:Animals; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000254:growth & development* / Q000473:pathology; D007414:Intestinal Neoplasms / Q000473:pathology / Q000503:physiopathology*; D008322:Mammals; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D014158:Transcription, Genetic