title: Comparison of T2-weighted and fluid-attenuated inversion-recovery fast spin-echo MR sequences in intracerebral AIDS-associated disease.
abstract: OBJECTIVE
  To compare the value of fast fluid-attenuated inversion-recovery (FLAIR) with T2-weighted fast spin-echo MR imaging in the detection of acquired immunodeficiency virus (AIDS)-related lesions of the brain.
  
  
  METHODS
  Forty-four human immunodeficiency virus (HIV)-positive patients were examined with both sequences on either a 1.0-T or a 1.5-T MR system. The number, size, location, and conspicuity of the lesions were evaluated by two independent observers. Contrast ratios between lesions and normal brain/cerebrospinal fluid were determined, and contrast-to-noise ratios were calculated.
  
  
  RESULTS
  FLAIR was found to be superior to T2-weighted fast spin-echo in detection of small lesions and of lesions located in cortical/subcortical regions and deep white matter. The two techniques were equal in delineation of lesions larger than 2 cm and for lesions located in the basal ganglia and posterior fossa. In 24 patients, more lesions were detected with the FLAIR fast spin-echo technique. Lesion/cerebrospinal fluid contrast ratios and contrast-to-noise ratios were significantly higher for the FLAIR fast spin-echo sequences than for the T2-weighted fast spin-echo sequences.
  
  
  CONCLUSIONS
  FLAIR allows early detection of small lesions in subcortical and cortical locations, especially in HIV encephalitis. Because of its improved lesion detection rate and greater overall lesion conspicuity, we believe FLAIR is useful in the evaluation of subtle changes in the brains of AIDS patients with central nervous system disease, and could even replace the T2-weighted fast spin-echo technique.
authors.affiliation: Department of Radiology, University of Vienna, Austria.
authors.forename: M M
authors.initials: MM
authors.lastname: Thurnher
authors.forename: S A
authors.initials: SA
authors.lastname: Thurnher
authors.forename: D
authors.initials: D
authors.lastname: Fleischmann
authors.forename: A
authors.initials: A
authors.lastname: Steuer
authors.forename: A
authors.initials: A
authors.lastname: Rieger
authors.forename: T
authors.initials: T
authors.lastname: Helbich
authors.forename: S
authors.initials: S
authors.lastname: Trattnig
authors.forename: E
authors.initials: E
authors.lastname: Schindler
authors.forename: K
authors.initials: K
authors.lastname: Hittmair
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis*; D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006679:HIV Seropositivity / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012680:Sensitivity and Specificity