[A study of CD23 expression and regulation in the patients with asthma].
To study the pathogenesis of asthma, we examined the CD23 expression on peripheral blood mononuclear cells (PBMC) from 25 healthy donors and 28 asthmatic patients with APAAP test. The results demonstrated that CD23 antigen expressed strongly on PBMC from patients and their PBMC correlated positively with their IgE level (r = 0.78 P < 0.01). We investigated the regulation of CD23 expression by IL-4 and IFN-gamma in vitro, the results demonstrated that IFN-gamma could inhibit spontaneous and IL-4 induced expression of CD23. It was suggested that the analysis of the percentage of positive CD23 expression is useful for making diagnosis and assessing severity of asthma and is of significance in elucidating the pathogenesis of the asthma.
Fu
Z
Z
First Affiliated Hospital, Lanzhou Medical College.
Xing
Z
Z
D000328:Adult; D001249:Asthma / Q000276:immunology*; D002478:Cells, Cultured; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007371:Interferon-gamma / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008875:Middle Aged; D017455:Receptors, IgE / Q000096:biosynthesis*
D017455:Receptors, IgE; D007073:Immunoglobulin E; D007371:Interferon-gamma