[Clinical importance of p53 gene mutation and PCNA expression in ureteral and renal pelvic cancers].
In order to know the clinical importance of p53 gene mutation and PCNA expression in ureteral and renal pelvic cancers, research was carried out with immunohistochemistry S-P method in 45 cases. Mutant p53 nuclear staining was positive in 24 cases (53.3%) and correlated with PCNA expression, being higher in clinical stages T3 and T4 than in T1 + T2. They also correlated with the grade of cell differentiation, being higher in G3 than in G1 + G2.
Kong
C
C
Department of Urology, First Affiliated Hospital, China Medical University, Shenyang.
Liu
T
T
Zhang
M
M
D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000401:mortality; D007682:Kidney Pelvis; D009154:Mutation; D009364:Neoplasm Recurrence, Local; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D015996:Survival Rate; D014516:Ureteral Neoplasms / Q000235:genetics* / Q000401:mortality
D018809:Proliferating Cell Nuclear Antigen