[Estrogen therapy in women with postmenopausal osteoporosis].
BACKGROUND
The effects of estrogen-therapy on bone mineral density and the incidence of fractures in 132 women with postmenopausal osteoporosis have been studied.


METHODS
The patients were randomly assigned to receive placebo or estrogens (0.15 or 0.3 or 0.625 mg) for 64 months. Bone mineral density of the lumbar spine was measured by dual-energy X-ray absorptiometry with the use of Hologic QR-1000 densitometers, in all women.


RESULTS
A significant increase in bone mineral density was observed in women receiving estrogens, whereas in those receiving placebo there was a decrease in bone mineral density.
Zarcone
R
R
Istituto di Ostetricia e Ginecologia, II Università degli Studi, Napoli.
Carfora
E
E
Sergio
F
F
Bellini
P
P
Longo
M
M
Tartaglia
E
E
Tomasillo
G
G
D000368:Aged; D015519:Bone Density; D002113:Calcification, Physiologic / Q000187:drug effects; D003720:Densitometry; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D005598:Fractures, Spontaneous / Q000517:prevention & control; D006801:Humans; D008161:Lumbosacral Region / Q000293:injuries; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D010919:Placebos; D012307:Risk Factors
D004966:Estrogens, Conjugated (USP); D010919:Placebos