Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Kuro-o
M
M
Division of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan. kuroo@ncnaxp.ncnp.go.jp
Matsumura
Y
Y
Aizawa
H
H
Kawaguchi
H
H
Suga
T
T
Utsugi
T
T
Ohyama
Y
Y
Kurabayashi
M
M
Kaname
T
T
Kume
E
E
Iwasaki
H
H
Iida
A
A
Shiraki-Iida
T
T
Nishikawa
S
S
Nagai
R
R
Nabeshima
Y I
YI
D000375:Aging / Q000235:genetics* / Q000473:pathology; D000595:Amino Acid Sequence; D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics / Q000473:pathology; D001284:Atrophy; D002114:Calcinosis / Q000235:genetics / Q000473:pathology; D003001:Cloning, Molecular; D004646:Emphysema / Q000235:genetics; D005260:Female; D005835:Genitalia / Q000473:pathology; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D010024:Osteoporosis / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D010902:Pituitary Gland / Q000473:pathology; D017386:Sequence Homology, Amino Acid; D012867:Skin / Q000473:pathology; D013577:Syndrome; D013950:Thymus Gland / Q000473:pathology
D008565:Membrane Proteins