title: [Analgesic action of microinjection of neurokinin A into the lateral reticular nucleus and nucleus raphe magnus in rats].
abstract: Using the microinjection technique, the analgesic effect of neurokinin A (NKA) microinjected into the lateral reticular nucleus (LRN) and nucleus raphe magnus (NRM) was investigated in lightly pentobarbital-anesthetized rats using tail flick latency (TFL) as an index. Microinjection of NKA (0.5 microgram/0.5 microliter) into LRN significantly increased TFL lasting for 10 min (n = 12, P < 0.001). Microinjection of the same amount of NKA into NRM also produced evident increase in TFL for 5 min (n = 13, P < 0.001). The results indicate that NKA modulates pain reaction in both LRN and NRM in rats.
authors.affiliation: Air Force Tianjin Hospital.
authors.forename: G P
authors.initials: GP
authors.lastname: Yan
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: Q E
authors.initials: QE
authors.lastname: Huang
authors.forename: W M
authors.initials: WM
authors.lastname: Chen
mesh_terms: D015667:Acupuncture Analgesia; D000818:Animals; D015671:Electroacupuncture; D008845:Microinjections; D015288:Neurokinin A / Q000494:pharmacology*; D017288:Pain Threshold; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012154:Reticular Formation / Q000502:physiology*
chemical_list: D015288:Neurokinin A