title: Local delivery of an amino bisphosphonate prevents the resorptive phase of alveolar bone following mucoperiosteal flap surgery in rats.
abstract: Mucoperiosteal flaps are used to access the bone and root surface in a wide range of periodontal procedures and in implant surgery. We have demonstrated that the mucoperiosteal surgical flap of the rat mandible produces a transient burst of alveolar bone resorption similar to the clinical observations in humans. This resorptive activity, when coupled with local irritation factors, may cause confined alveolar bone loss. Recently, we have demonstrated that an amino bisphosphonate, which is used in preventing systemic bone resorption in osteoporosis and other bone diseases, reduces alveolar bone resorption in the rat model when administered systemically. In this study we evaluated the effect of local delivery of the amino bisphosphonate on bone resorption associated with mucoperiosteal flaps. Following mucoperiosteal flap elevation in the premolar and molar region of the rat mandible, a surgical pellet soaked with amino bisphosphonate was locally applied on the exposed bone surface and covered by flap. The results show that local delivery of amino bisphosphonate reduces significantly alveolar bone resorption activated by mucoperiosteal flap surgery. This study suggests that local application of amino bisphosphonate can be used as an adjunct in therapy for reducing bone resorption following surgery.
authors.affiliation: Department of Prosthodontics, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Yaffe
authors.forename: M
authors.initials: M
authors.lastname: Iztkovich
authors.forename: Y
authors.initials: Y
authors.lastname: Earon
authors.forename: I
authors.initials: I
authors.lastname: Alt
authors.forename: R
authors.initials: R
authors.lastname: Lilov
authors.forename: I
authors.initials: I
authors.lastname: Binderman
mesh_terms: D000287:Administration, Topical; D019386:Alendronate / Q000008:administration & dosage / Q000627:therapeutic use*; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D001847:Bone Diseases / Q000517:prevention & control; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003757:Dental Implantation / Q000009:adverse effects; D007091:Image Processing, Computer-Assisted; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D008852:Microradiography; D010012:Osteogenesis; D010024:Osteoporosis / Q000517:prevention & control; D010510:Periodontal Diseases / Q000601:surgery; D011183:Postoperative Complications; D051381:Rats; D017208:Rats, Wistar; D013524:Surgical Flaps / Q000009:adverse effects*; D014092:Tooth Root / Q000601:surgery
chemical_list: D019386:Alendronate