[Study on pharmacokinetic characteristics of tetramethylpyrazine and hemodynamics of heart blood stasis in dogs].
"Blood stasis syndrome pharmacokinetics" means the pathophysiological state of blood stasis syndrome affectes significantly the pharmacokinetic parameters. In order to provide scientific evidence for the new hypothesis, the authors studied the hemodynamic changes induced by quantitative coronary artery stenosis and pharmacokinetics of tetramethylpyrazine (TMP) in dog model with heart blood stasis (HBS) and in normal dog (for control) simultaneously. Compared with healthy dog, serum TMP concentration, drug concentration time, area under curve (AUC) and t1/2 beta in HBS dog were increased significantly (P < 0.01). The mechanism might be related with the abnormal changes in hemodynamics (indude decrease in cardiac output, left ventricular systolic pressure and coronary blood flow, etc.) caused by coronary artery stenosis.
Huang
X
X
Xijing Hospital, Fourth Military Medical University, Xi'an.
Jiang
Y P
YP
Zang
Y M
YM
D000818:Animals; D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D008297:Male; D011719:Pyrazines / Q000493:pharmacokinetics* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000493:pharmacokinetics* / Q000494:pharmacology
D011719:Pyrazines; D014665:Vasodilator Agents; C017953:tetramethylpyrazine