[Measuring ionized calcium (Ca2+) transport during intermittent peritoneal dialysis (IPD)].
The aim of studies was an evaluation of dialysate/plasma ratio and peritoneal balance of Ca2+ during IPD performed using 1.5 g% glucose and 1.75 mmol/l Ca2+ dialysis solution. Net ultrafiltration rate and EPBF were simultaneously examined. Studies were carried out using dialysis solution without any drugs except heparin (n = 10) and with intraperitoneal administration of sodium nitroprusside (n = 11), chlorpromazine (n = 10) and isoprenaline hydrochloride (n = 10) in the doses of 5, 2.5 and 0.5 mg/l of dialysis solution, respectively. During IPD conducted with 1.75 mmol/l Ca2+ dialysis solution, in 2-7% of patients hypercalcaemia (Ca2+ > 1.5 mmol/l) was present. It was promoted by Ca2+ absorption from dialysis solution to blood, observed in all patients. Chlorpromazine but not sodium nitroprusside or isoprenaline hydrochloride influenced significantly peritoneal transfer of Ca2+, decreasing its absorption from the peritoneal cavity. Chlorpromazine-induced changes in peritoneal transfer of Ca2+ were not a result of the drug influence on EPBF, which was not significantly different in patients dialysed without and with drugs. Ultrafiltration rate induced by 1.5 g% glucose dialysis solution did not exert significant influence on Ca2+ transport.
Grzegorzewska
A
A
Kliniki Nefrologii Instytutu Chorób Wewnetrznych Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu.
Chalama
B
B
Mariak
I
I
Kupsz
J
J
D000042:Absorption / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D002746:Chlorpromazine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007274:Injections, Intraperitoneal; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000008:administration & dosage; D010530:Peritoneal Dialysis; D014462:Ultrafiltration
D009599:Nitroprusside; D007545:Isoproterenol; D002118:Calcium; D002746:Chlorpromazine