Neuronal specification: generating diversity in the spinal cord.
Graded Sonic hedgehog signaling may generate neuronal diversity in the ventral spinal cord in two steps: the creation of a generic population of ventral progenitors, followed by the Pax6-dependent generation of distinct subpopulations within these ventral progenitors.
Pituello
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Centre de Biologie du Développement, UMR-CNRS 5547 affiliée à I'INSERM, Université P. Sabatier, Toulouse, France.
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D053823:Hedgehog Proteins; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D011506:Proteins / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D015534:Trans-Activators
D053823:Hedgehog Proteins; D011506:Proteins; D015534:Trans-Activators