title: [Interaction of soda lime and halogenated anesthetics].
abstract: The increased use of soda lime for low flow anaesthesia leads to some problems related to the interaction with halogenated agents. These agents may be absorbed by soda lime or degradated according to their water content. Halothane and enflurane, in contact with soda lime, produce some metabolites, but their concentration is low when compared to their own lethal concentration. Sevoflurane degradates to four compounds. Compound A may reach a value between 13.3-42.1 ppm in the inspired fraction: these values are 50-100 times lower than the toxic concentrations. Isoflurane and desflurane are degradable at very low extent. Some case reports of unexpected high carboxyhemoglobin levels during anaesthesia indicate the possibility of CO production from soda lime and baralyme when halogenated agents are used. This reaction occurs only with anaesthetics containing CHF2-moiety (isoflurane, enflurane and desflurane) and when some specific factors make soda lime or baralyme completely dry. Low flow anaesthesia preserves the moisture content of the soda lime and protects from carbon monoxide production, by increasing water content in the circle.
authors.affiliation: Istituto Scientifico H San Raffaele, Cattedra di Anestesiologia e Rianimazione, Università degli Studi, Milano.
authors.forename: G
authors.initials: G
authors.lastname: Torri
authors.forename: C
authors.initials: C
authors.lastname: Montani
authors.forename: C
authors.initials: C
authors.lastname: Tommasino
mesh_terms: D000042:Absorption; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics*; D017610:Calcium Compounds / Q000493:pharmacokinetics*; D002245:Carbon Dioxide / Q000493:pharmacokinetics; D002248:Carbon Monoxide / Q000378:metabolism; D000077335:Desflurane; D004347:Drug Interactions; D004987:Ethers / Q000493:pharmacokinetics; D007530:Isoflurane / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D008738:Methyl Ethers; D010087:Oxides / Q000493:pharmacokinetics*; D000077149:Sevoflurane; D012972:Sodium Hydroxide / Q000493:pharmacokinetics*
chemical_list: D018685:Anesthetics, Inhalation; D017610:Calcium Compounds; D004987:Ethers; D008738:Methyl Ethers; D010087:Oxides; D002245:Carbon Dioxide; D000077149:Sevoflurane; C004569:soda lime; D012972:Sodium Hydroxide; D002248:Carbon Monoxide; D000077335:Desflurane; D007530:Isoflurane