New recommendations for poliovirus vaccination. Combination regimen captures best effects of available vaccines.
Unfortunately, wild poliovirus still exists in pockets around the world, so immigrants and travelers remain a potential source of infection. In addition, a few cases of vaccine-associated paralytic poliomyelitis are reported each year with use of oral vaccine alone. Fortunately, US physicians have three highly effective and acceptable options for poliomyelitis immunization. Physician and patient preferences may influence the choice, but the sequential parenteral-oral vaccine schedule is a reasoned balance of risks and benefits and should be promoted as the preferred regimen of routine vaccination of healthy children.
Conrad
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DA
Department of Pediatrics, University of Texas Health Science Center at San Antonio 78284-7811, USA.
Jenson
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HB
D000328:Adult; D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D011051:Poliomyelitis / Q000209:etiology / Q000517:prevention & control*; D017955:Poliovirus / Q000145:classification / Q000276:immunology; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D017410:Practice Guidelines as Topic
D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral