[Dynamic change of beta 2-microglobulin in hemodialysis].
In order to study the dynamic clearance of total beta 2-microglobulin in the body, two-compartment theory and perturbation solution were applied in our study. Based on the rate of formation of beta 2-microglobulin in the body and the mode of transmission and mass transfer resistance of solute, the concept of week clearance index of beta 2-microglobulin (R value) was suggested. Its theoretical value is more than 40%. Thirty-two patients undergoing dialysis with high-efficiency dialyzer were studied and data were processed in a computer. The results showed that when R value was more than 40%, the clinical manifestation of amyloidosis carpal tunnel syndrome induced by increase of beta 2-microglobulin was alleviated obviously. It makes up for the limitation of KT/V or TA Curea that were used only to estimate adequate dialysis of small molecules. It is shown that the concept of week cleacance index of beta 2-microglobulin improves the estimation of adequate dialysis.
Jiang
A
A
Second Hospital of Tianjin Medical University.
Qi
W
W
Zhang
F
F
D000328:Adult; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D001613:beta 2-Microglobulin / Q000096:biosynthesis*
D001613:beta 2-Microglobulin