Survival trees with time-dependent covariates: application to estimating changes in the incubation period of AIDS.
Tree-structured methods for exploratory data analysis have previously been extended to right-censored survival data. We further extend these methods to allow for truncation and time-dependent covariates. We apply the new methods to a data set on incubation times of acquired immunodeficiency syndrome (AIDS), using calendar time as a time-dependent covariate. Contrary to expectation, we find that rates of progression to AIDS appear to be faster after August 1989 than before.
Bacchetti
P
P
Department of Epidemiology and Biostatistics, University of California, San Francisco 94143-0840, USA. peter@biostat.ucsf.edu
Segal
M R
MR
D000328:Adult; D018450:Disease Progression; D006679:HIV Seropositivity / Q000453:epidemiology*; D006801:Humans; D008297:Male; D015233:Models, Statistical; D009426:Netherlands / Q000453:epidemiology; D009518:New York / Q000453:epidemiology; D012495:San Francisco / Q000453:epidemiology; D016019:Survival Analysis; D013997:Time Factors; D017735:Virus Latency