Treatment of canine pyoderma with co-amoxyclav: a comparison of two dose rates.
The efficacy of oral co-amoxyclav, administered twice daily for up to 12 weeks either at the manufacturer's dose rate of 12.5 mg/kg or at 25.0 mg/kg, in curing the lesions of canine folliculitis, furunculosis and cellulitis was compared in a blind study. A total of 97 dogs entered the trial and 67 completed it. There was no significant difference in the rate of cure or the duration of therapy. The lesions of folliculitis were cured in 91.5 per cent of cases, in a mean period of 25.3 days. Furunculosis and cellulitis were cured respectively in 87.5 per cent and 60.0 per cent of the dogs, in mean periods of 37.6 and 44.7 days. The standard dose rate was very effective in folliculitis and furunculosis and there was no benefit in doubling the dose. Too few cases of cellulitis were treated to provide a reliable dose comparison.
Lloyd
D H
DH
Dermatology Unit, Royal Veterinary College, North Mymms, Hatfield.
Carlotti
D N
DN
Koch
H J
HJ
Van den Broek
A H
AH
D000658:Amoxicillin / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy / Q000662:veterinary; D002481:Cellulitis / Q000188:drug therapy / Q000662:veterinary; D019818:Clavulanic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000008:administration & dosage* / Q000494:pharmacology; D005667:Furunculosis / Q000188:drug therapy / Q000662:veterinary; D010406:Penicillins / Q000008:administration & dosage* / Q000494:pharmacology; D011711:Pyoderma / Q000188:drug therapy / Q000662:veterinary*; D011897:Random Allocation; D016037:Single-Blind Method; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D010406:Penicillins; D019818:Clavulanic Acid; D000658:Amoxicillin