A graphical method for detecting recombination in phylogenetic data sets.
Current phylogenetic tree reconstruction methods assume that there is a single underlying tree topology for all sites along the sequence. The presence of mosaic sequences due to recombination violates this assumption and will cause phylogenetic methods to give misleading results due to the imposition of a single tree topology on all sites. The detection of mosaic sequences caused by recombination is therefore an important first step in phylogenetic analysis. A graphical method for the detection of recombination, based on the least squares method of phylogenetic estimation, is presented here. This method locates putative recombination breakpoints by moving a window along the sequence. The performance of the method is assessed by simulation and by its application to a real data set.
McGuire
G
G
Department of Mathematics and Statistics, University of Edinburgh, Scotland. grainne@bioss.sari.ac.uk
Wright
F
F
Prentice
M J
MJ
D003198:Computer Simulation; D004269:DNA, Bacterial / Q000235:genetics; D016208:Databases, Factual; D004926:Escherichia coli / Q000235:genetics; D019143:Evolution, Molecular; D016018:Least-Squares Analysis; D008957:Models, Genetic; D009030:Mosaicism; D009343:Neisseria / Q000235:genetics; D010802:Phylogeny; D011995:Recombination, Genetic
D004269:DNA, Bacterial