Antimicrobial and genotoxic activities of N-hydroxyalkyl-1, 2-benzisothiazol-3(2H)-one carbamic esters.
N-Hydroxyethyl- and N-hydroxypropyl-1,2-benzisothiazol-3(2H)-one carbamic esters were prepared in order to test their activity against representative bacterial and fungal strains. The obtained results were compared with those reported for parent alcohols and some interesting considerations were drawn. None of the studied derivatives possess genotoxic activity in the Bacillus subtilis rec-assay and Salmonella-microsome test.
Carmellino
M L
ML
Dipartimento di Chimica Farmaceutica, Università degli Studi, Pavia, Italy.
Pagani
G
G
Terreni
M
M
Pregnolato
M
M
Borgna
P
P
Pastoni
F
F
Zani
F
F
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics; D002176:Candida albicans / Q000187:drug effects; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D003016:Clostridium perfringens / Q000187:drug effects; D004269:DNA, Bacterial / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013210:Staphylococcus / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D002219:Carbamates; D004269:DNA, Bacterial; D009153:Mutagens; D013844:Thiazoles