[The value of determining guanine deaminase in diagnosis of hepatic diseases].
We determined the Guanine Deaminase (GD) activity of 200 patients with different diseases. It was found that GD activity of hepatic patients is higher than that of health adults, while the GD activity of other patients is in the normal range. There is a linear correlation between GD activity and ALT in patients with chronic hepatitis, billiary obstruction, and between GD activity and total bilirubin in patients with chronic active hepatitis, biliary obstruction and liver cirrhosis. Moreover, the GD activity of patients positive for anti-HCV is significantly increased. So GD activity in serum is a specific and sensitive index to estimating hepatic functions and can be used in the diagnosis of acute and chronic hepatitis, cirrhosis of liver, and C virus hepatitis.
Li
P
P
Department of Laboratory Medicine, First Affiliated Hospital, Chengdu.
Xu
S
S
Gao
B
B
Cao
F
F
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D004796:Clinical Enzyme Tests; D006148:Guanine Deaminase / Q000097:blood*; D006526:Hepatitis C / Q000175:diagnosis / Q000201:enzymology; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000201:enzymology; D008107:Liver Diseases / Q000175:diagnosis* / Q000201:enzymology
D000410:Alanine Transaminase; D006148:Guanine Deaminase; D001663:Bilirubin