title: C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.
abstract: The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.
authors.forename: J
authors.initials: J
authors.lastname: Brandsen
authors.forename: S
authors.initials: S
authors.lastname: Werten
authors.forename: P C
authors.initials: PC
authors.lastname: van der Vliet
authors.forename: M
authors.initials: M
authors.lastname: Meisterernst
authors.forename: J
authors.initials: J
authors.lastname: Kroon
authors.forename: P
authors.initials: P
authors.lastname: Gros
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D018360:Crystallography, X-Ray; D004277:DNA, Single-Stranded / Q000378:metabolism*; D019281:Dimerization; D006801:Humans; D017874:Immediate-Early Proteins; D008565:Membrane Proteins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D012097:Repressor Proteins; D015534:Trans-Activators / Q000737:chemistry*
chemical_list: D004277:DNA, Single-Stranded; C490043:IFRD2 protein, human; D017874:Immediate-Early Proteins; D008565:Membrane Proteins; D012097:Repressor Proteins; D015534:Trans-Activators