[Evaluation of selected parameters of connective tissue metabolism in patients with primary open angle glaucoma].
OBJECTIVE
To evaluate the plasma concentration of P I CP and P III NP as markers of the connective tissue metabolism in human with and without POAG. The mechanical properties of the collagen could be one of the common factors involved in the pathogenesis of chronic open angle glaucoma.


METHODS
P I CP and P III NP were studied in serum in 20 patients with POAG and in 10 healthy subjects using RIA method.


RESULTS
The concentration of P III NP in the blood serum was markedly increased (3.99 +/- 1.5 micrograms/l) compared with control group (2.84 +/- 0.77 micrograms/l), p < 0.05. There was not significant difference in concentration of P I CP in both groups.
Nowak
M
M
I Katedry i Zakładu Patofizjologii oraz Katedry Analityki Medycznej Slaskiej AM w Zabrzu.
Swietochowska
E
E
Buntner
B
B
Bandych-Biniszkiewicz
D
D
Pojda
S
S
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D011863:Radioimmunoassay
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; C042813:procollagen type I carboxy terminal peptide; D003094:Collagen