title: [Circadian hydroxyprolinuria in the early diagnosis of nephrosclerosis in patients with chronic pyelonephritis].
abstract: The time course of daily urinary excretion of hydroxyproline (HOP) was followed up in patients with chronic pyelonephritis. Manifest hyperhydroxyprolinuria was observed in these patients at the earliest stages of nephrosclerosis, and it augmented with development of renal insufficiency. Measurements of HOP in the urine of patients with chronic pyelonephritis is proposed as an indicator reflecting the metabolic status of renal connective tissue at the early stages of nephrosclerosis. It can be used to assess the activity of the sclerotic process in the kidneys of patients with chronic pyelonephritis, predict the disease course and outcome, and, probably, to develop methods of adequate pathogenetic therapy with biochemical monitoring. The method is not invasive, sufficiently informative, and available for clinical diagnostic laboratories.
authors.forename: S B
authors.initials: SB
authors.lastname: Pavlov
mesh_terms: D002908:Chronic Disease; D002940:Circadian Rhythm; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D009400:Nephrosclerosis / Q000175:diagnosis* / Q000503:physiopathology / Q000652:urine; D011237:Predictive Value of Tests; D011704:Pyelonephritis / Q000473:pathology* / Q000503:physiopathology / Q000652:urine
chemical_list: D006909:Hydroxyproline