title: Effect of ocular perfusion pressure on retinal function in the rabbit.
abstract: The electroretinogram (ERG) vs perfusion pressure relation was studied in anesthetized rabbits during mechanically induced changes in mean arterial pressure (MAP). After 1 hr of dark adaptation, ERGs were obtained at perfusion pressures from 10 to 95 mmHg with each pressure held for 30-60 sec, and at three levels from 15 to 75 mmHg with each pressure held for 5 min. The slopes of the b-wave amplitude vs perfusion pressure data were not significantly different from zero during either the brief or longer manipulations of perfusion pressure. However, the b-wave was nearly extinguished 5 min after death. The results indicate that the rabbit ERG is maintained over a wide range of perfusion pressure.
authors.affiliation: Department of Ophthalmology, University of Texas Health Science Center, San Antonio 78284, USA. harrisonj@uthscsa.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Harrison
authors.forename: J W
authors.initials: JW
authors.lastname: Kiel
authors.forename: S
authors.initials: S
authors.lastname: Smith
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002829:Choroid / Q000098:blood supply; D003623:Dark Adaptation / Q000502:physiology; D004596:Electroretinography; D005123:Eye / Q000098:blood supply*; D007429:Intraocular Pressure / Q000502:physiology; D011817:Rabbits; D012039:Regional Blood Flow; D012160:Retina / Q000502:physiology