title: Effects of uni- and bilateral phrenicotomy on active and passive respiratory mechanics in rats.
abstract: Eighteen spontaneously breathing anesthetized rats were selected to belong to three groups: control (C), unilateral (U), and bilateral phrenicotomy (B). Eight days after surgery, the passive and active mechanical properties of the respiratory system, the shape of the occlusion pressure wave, the decay of inspiratory muscle activity during expiration and control of breathing were analysed. Passive and active elastances increased significantly from C to U and from U to B. Passive and active time constants decreased either in uni- or bilateral phrenicotomies. Passive and active resistances remained unaltered. The intensity of respiratory drive increased from C to U and B. In conclusion, uni- and bilateral phrenicotomies increase the elastic load of the respiratory system, because of both its passive and active components, which raised the respiratory neuromuscular drive of the remaining muscles. Consequently, minute ventilation remained unchanged. The higher frequency was allowed for, by a shorter time constant of the respiratory system and by a faster decay of post-inspiratory muscle activity.
authors.affiliation: Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, Brazil.
authors.forename: P R
authors.initials: PR
authors.lastname: Rocco
authors.forename: D S
authors.initials: DS
authors.lastname: Faffe
authors.forename: M
authors.initials: M
authors.lastname: Feijóo
authors.forename: S L
authors.initials: SL
authors.lastname: Menezes
authors.forename: F P
authors.initials: FP
authors.lastname: Vasconcellos
authors.forename: W A
authors.initials: WA
authors.lastname: Zin
mesh_terms: D000399:Air Pressure; D000818:Animals; D007839:Functional Laterality / Q000502:physiology; D005652:Functional Residual Capacity / Q000502:physiology; D010791:Phrenic Nerve / Q000502:physiology*; D051381:Rats; D012121:Respiration, Artificial; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000502:physiology; D014132:Trachea / Q000502:physiology