Jerk-locked back averaging and dipole source localization of magnetoencephalographic transients in a patient with epilepsia partialis continua.
In order to localize the generator site of epileptiform discharges, we applied the techniques of jerk-locked back averaging (JBA) of magnetoencephalographic (MEG) activities and dipole source localization in a patient with epilepsia partialis continua (EPC), who showed continuous, focal myoclonic jerks in the right arm. The myoclonic discharges in the right thenar muscle were used as a trigger pulse. JBA revealed consistent EEG and MEG transients that coincided consistently and constantly preceded the myoclonic jerks. The estimated dipoles of MEG were localized in a restricted area in the left precentral area, which closely correlated with the area of epileptic discharges recorded in electrocorticography. Therefore, JBA of MEG is considered to be a useful non-invasive method for localizing the epileptogenic area in EPC.
Shigeto
H
H
Department of Clinical Neurophysiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Tobimatsu
S
S
Morioka
T
T
Yamamoto
T
T
Kobayashi
T
T
Kato
M
M
D000368:Aged; D002540:Cerebral Cortex / Q000503:physiopathology; D004562:Electrocardiography; D004569:Electroencephalography; D004576:Electromyography; D004828:Epilepsies, Partial / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male