title: Use of sustained release vehicles in the treatment of Meniere's disease.
abstract: Over the years, a variety of empirical regimens have evolved using intratympanic gentamicin to treat the vertigo associated with Meniere's disease. Although these regimens have been effective, their application is not without risk. Many of the problems associated with intratympanic medications could be overcome with the use of a sustained release vehicle. This article examines the role of such vehicles in the treatment of Meniere's disease and how sustained release vehicles might impact future treatment for this disabling disease.
authors.affiliation: Department of Otolaryngology, Naval Medical Center San Diego, San Diego, California 92134-5000, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Hoffer
authors.forename: B
authors.initials: B
authors.lastname: Balough
authors.forename: J
authors.initials: J
authors.lastname: Henderson
authors.forename: M
authors.initials: M
authors.lastname: DeCicco
authors.forename: D
authors.initials: D
authors.lastname: Wester
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Leary
authors.forename: R
authors.initials: R
authors.lastname: Kopke
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D006801:Humans; D008575:Meniere Disease / Q000628:therapy*; D013997:Time Factors
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D015718:Fibrin Tissue Adhesive