Assignment of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) between D3S3118 and GCT4B10 on the short arm of chromosome 3 by somatic cell hybrid analysis.
We have determined the chromosomal location of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) to the short arm of chromosome 3 using somatic cell hybrids. PCR-based analysis of a 'monochromosomal' hybrid panel identified the presence of the TNNC1 gene on human chromosome 3 and subsequent analysis of the Genebridge4 radiation hybrid panel located the gene between D3S3118 (7.3cR) and GCT4B10 (4.2cR) with a lod score of > 3.0.
Townsend
P J
PJ
Imperial College School of Medicine, National Heart and Lung Institute, London.
Yacoub
M H
MH
Barton
P J
PJ
D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005796:Genes / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008126:Lod Score; D019209:Troponin C / Q000235:genetics*
D019209:Troponin C