[Hypolipidemic action of soy fiber and its effects on platelet aggregation and coagulation time in rats].
In order to lay a scientific basis for the development and use of soy bean, six per cent of soy fiber (SF) and pure cellulose were added to normal feed containing 1% of cholesterol and 0.2% bile salt, to feed SD rats, as compared with a control group of rats fed only with the normal feed, to study the effects of fibers on blood lipid concentration, platelet aggregation and clotting time. Results showed SF could not only significantly lower serum total cholesterol (TC), LDL-C and atherosclerotic index, and increase the ratio of HDL-L/TC, but also significantly lower serum fibrinogen (FB) and platelet aggregation, prolong clotting time (P < 0.01). NO such effects were observed in rats fed with pure cellulose. The authors believed that hypolipidemic effect of SF was achieved by lowering LDL-C in animals with hyperlipemia, and lowering of blood lipid and FB were major reasons to make animals fed with SF-added feed lower their platelet aggregation and prolong their clotting time.
Wang
C
C
Department of Life Science, Shanxi University, Taiyuan.
Zhao
L
L
Chen
Y
Y
D000818:Animals; D004043:Dietary Fiber / Q000627:therapeutic use*; D005340:Fibrinogen / Q000378:metabolism; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy*; D008297:Male; D010974:Platelet Aggregation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max / Q000737:chemistry*; D014914:Whole Blood Coagulation Time
D004043:Dietary Fiber; D005340:Fibrinogen