Clear cell tumors of the female genital tract.
Clear cell adenocarcinomas of the vagina, cervix, endometrium, and ovaries show very similar histological features. Several other tumors and tumor-like lesions of the female genital tract may also contain clear cells and may occasionally be misinterpreted as clear cell adenocarcinomas. These conditions include microglandular hyperplasia, mesonephric hyperplasia, Arias-Stella change, smooth muscle tumors containing clear cells, dysgerminoma, yolk sac tumor, metastatic renal cell carcinoma, steroid cell tumors, hepatoid carcinomas, signet-ring-cell stromal tumors, and trophoblastic tumors. This review discusses the histological features of all of these lesions, emphasizing the morphological aspects that are essential to accurate differential diagnosis.
Matias-Guiu
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Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain.
Lerma
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Prat
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D018262:Adenocarcinoma, Clear Cell / Q000139:chemically induced / Q000473:pathology*; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000556:secondary; D003937:Diagnosis, Differential; D004054:Diethylstilbestrol / Q000009:adverse effects; D016889:Endometrial Neoplasms / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000139:chemically induced / Q000473:pathology* / Q000556:secondary; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000473:pathology; D014625:Vaginal Neoplasms / Q000139:chemically induced / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology
D004054:Diethylstilbestrol