title: Renal oncocytoma with t(5;12;11), der(1)1;8) and add(19): "true" oncocytoma or chromophobe adenoma?
abstract: Renal oncocytomas reveal a considerable (cyto)genetic heterogeneity. At least 2 genetic subsets are currently recognized, characterized by (1) translocations involving breakpoint 11q13 and (2) the combined loss of chromosomes 1 and X/Y. We present a case of oncocytoma revealing a 3-way translocation involving breakpoint 11q13, a der(1)t(1;8) and an add(19). The der(1) resulted in loss of chromosome 1 sequences. Using fluorescence in situ hybridization, the 11q13 breakpoint of the present case proved to be slightly different from the one observed previously in 3 cases of renal oncocytoma. Whether the 11q13 breakpoint observed in our case resides in or near another gene remains to be elucidated.
authors.affiliation: Department of Medical Genetics, University of Groningen, The Netherlands. T.Dijkhuizen@med.rug.nl
authors.forename: T
authors.initials: T
authors.lastname: Dijkhuizen
authors.forename: E
authors.initials: E
authors.lastname: van den Berg
authors.forename: S
authors.initials: S
authors.lastname: Störkel
authors.forename: B
authors.initials: B
authors.lastname: de Vries
authors.forename: A Y
authors.initials: AY
authors.lastname: van der Veen
authors.forename: M
authors.initials: M
authors.lastname: Wilbrink
authors.forename: A
authors.initials: A
authors.lastname: Geurts van Kessel
authors.forename: B
authors.initials: B
authors.lastname: de Jong
mesh_terms: D018249:Adenoma, Oxyphilic / Q000235:genetics*; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic / Q000235:genetics*