Role of a single amino acid at the amino terminus of the simian virus 5 F2 subunit in syncytium formation.
The fusion (F) protein of simian virus 5 (strain W3A) induced extensive cell fusion in BHK cells when expressed alone, while that of strain WR did not. Mutational analysis demonstrated that the fusing activity can be transferred to the WR F protein by a proline residue at position 22 of subunit W3A F2.
Ito
M
M
Department of Microbiology, Mie University School of Medicine, Tsu, Japan.
Nishio
M
M
Kawano
M
M
Kusagawa
S
S
Komada
H
H
Ito
Y
Y
Tsurudome
M
M
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D015726:Giant Cells; D015707:HN Protein / Q000378:metabolism; D000882:Haplorhini / Q000821:virology; D011392:Proline; D018108:Respirovirus / Q000378:metabolism*; D014760:Viral Fusion Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
D015707:HN Protein; D014760:Viral Fusion Proteins; D011392:Proline