Expression of three rare fragile sites: chromosomal truncation, amplification of distal segment and telomeric renewal.
Fluorescence in situ hybridization with a telomeric probe was used to monitor telomeric renewal following breakage induced by the rare fragile sites FRA10A, FRA12A and FRA16B. Interstitial telomere-like sequences were detected only at the break sites of FRA10A.
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Department of Biology and Genetics, Medical Faculty, University of Milan, Via Viotti 3/5, I-20133 Milan, Italy.
Dalprà
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Larizza
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D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002879:Chromosomes, Human, Pair 10; D002881:Chromosomes, Human, Pair 12; D002885:Chromosomes, Human, Pair 16; D015342:DNA Probes; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D008297:Male; D016615:Telomere / Q000235:genetics*
D015342:DNA Probes