title: Intestinal fatty acid-binding protein variation associated with variation in the response of plasma lipoproteins to dietary fibre.
abstract: Increased dietary fibre intake is a component of prudent dietary advice, although the mechanism of its beneficial effect is unclear. Furthermore, plasma lipoprotein response to dietary fibre seems to vary both between individuals and according to the type of fibre consumed. Two common genetic variants, A54 and T54, of the intestinal fatty acid-binding protein gene (FABP2) have different in vitro binding affinities for long-chain fatty acids. We have hypothesized that variation in FABP2 would be associated with interindividual variation in the response of plasma lipoproteins to either dietary soluble or insoluble fibre. We studied 43 subjects who participated in a year-long cross-over study of the effect of insoluble and soluble fibre on plasma lipoproteins. We tested for associations between FABP2 genotypes and the response of plasma lipoproteins to dietary fibre. When compared with subjects homozygous for FABP2 A54, we found that subjects with FABP2 T54 had significantly greater decreases in plasma total and low-density lipoprotein (LDL)-cholesterol and apoB during the period when the diet was high in soluble fibre than during the period when the diet was high in insoluble fibre. Furthermore, compared with subjects with the FABP2 A54 allele, subjects with the FABP2 T54 allele had significantly lower secretion of total fecal bile acids, but this did not increase with dietary soluble fibre. Genetic variation in FABP2 may thus contribute to interindividual variation in the response of plasma lipoproteins to different dietary fibres, but the mechanism does not appear to be related to increases in fecal bile acid secretion.
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Toronto, Canada.
authors.forename: R A
authors.initials: RA
authors.lastname: Hegele
authors.forename: T M
authors.initials: TM
authors.lastname: Wolever
authors.forename: J A
authors.initials: JA
authors.lastname: Story
authors.forename: P W
authors.initials: PW
authors.lastname: Connelly
authors.forename: D J
authors.initials: DJ
authors.lastname: Jenkins
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics*; D018592:Cross-Over Studies; D004043:Dietary Fiber / Q000494:pharmacology*; D004224:Diterpenes; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005243:Feces / Q000737:chemistry; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007422:Intestines / Q000737:chemistry*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018996:Myelin P2 Protein / Q000235:genetics*; D009363:Neoplasm Proteins; D000084562:Retinyl Esters; D025521:Tumor Suppressor Proteins; D014801:Vitamin A / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D002352:Carrier Proteins; D004043:Dietary Fiber; D004224:Diterpenes; C493404:FABP2 protein, human; C107608:FABP7 protein, human; C493405:Fabp2 protein, mouse; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D008055:Lipids; D008074:Lipoproteins; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D000084562:Retinyl Esters; D025521:Tumor Suppressor Proteins; D014801:Vitamin A; C014794:retinol palmitate