Ideas crystallized on immunoglobulin superfamily-integrin interactions.
Interactions between immunoglobulin superfamily (IgSF) members and integrins are central to lymphocyte homing, leukocyte emigration into tissues at inflammatory sites, and in cell-cell interactions that lead to immune responses. Recent X-ray crystal structures reveal that the interaction of a divalent cation found in the integrin structure with an acidic residue from the IgSF partner may be important in binding.
de Fougerolles
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Wellcome Trust Immunology Unit, University of Cambridge School of Clinical Medicine, UK.
Springer
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D000818:Animals; D002450:Cell Communication / Q000502:physiology; D018360:Crystallography, X-Ray; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry*; D016023:Integrins / Q000737:chemistry*; D008968:Molecular Conformation
D007136:Immunoglobulins; D016023:Integrins