title: Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes.
abstract: Parkinson's disease (PD) patients often develop dementia, and Alzheimer's disease (AD) patients frequently develop parkinsonian signs. The apolipoprotein E epsilon4 allele is associated with increased risk and earlier onset of AD. We studied 137 unrelated white PD patients. Those with epsilon4 had the earliest onset (52.7 +/- 9.8 years), epsilon3/epsilon3 patients had an intermediate onset (56.1 +/- 11.1 years), and those with epsilon2 had the latest onset (59.1 +/- 13.4 years). The age at onset distribution for epsilon4/epsilon- was significantly earlier than for epsilon3/epsilon3 and epsilon2/epsilon3. These preliminary results suggest that apolipoprotein E genotypes modulate the age at onset of PD.
authors.affiliation: Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: S
authors.initials: S
authors.lastname: Zareparsi
authors.forename: J
authors.initials: J
authors.lastname: Kaye
authors.forename: R
authors.initials: R
authors.lastname: Camicioli
authors.forename: H
authors.initials: H
authors.lastname: Grimslid
authors.forename: B
authors.initials: B
authors.lastname: Oken
authors.forename: M
authors.initials: M
authors.lastname: Litt
authors.forename: J
authors.initials: J
authors.lastname: Nutt
authors.forename: T
authors.initials: T
authors.lastname: Bird
authors.forename: G
authors.initials: G
authors.lastname: Schellenberg
authors.forename: H
authors.initials: H
authors.lastname: Payami
mesh_terms: D017668:Age of Onset; D000368:Aged; D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E