Oxidative damage during hemodialysis using a vitamin-E-modified dialysis membrane: a preliminary characterization.
A comparison of the oxyradical exposure during hemodialysis (HD) carried out with vitamin-E-modified cellulose (CL-E) or conventional membranes, studying red blood cell (RBC) and plasma lipoperoxidation and RBC glutathione metabolism, was done. In this preliminary characterization of a new and original approach to the prevention of free radical damage in HD, the results obtained indicate that lipoperoxidation in plasma and RBC is decreased and therefore oxidative damage can be significantly decreased using CL-E dialysis membranes instead of conventional membranes.
Buoncristiani
U
U
Nephrology and Dialysis Unit, R. Silvestrini Hospital, Perugia, Italy.
Galli
F
F
Rovidati
S
S
Albertini
M C
MC
Campus
G
G
Canestrari
F
F
D000368:Aged; D000975:Antioxidants / Q000494:pharmacology; D002482:Cellulose; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D006435:Renal Dialysis / Q000009:adverse effects*; D014511:Uremia / Q000097:blood / Q000628:therapy; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D005609:Free Radicals; D006454:Hemoglobins; D008567:Membranes, Artificial; D014810:Vitamin E; D002482:Cellulose; D005978:Glutathione