[Genetic risk after high dose radioiodine therapy with regard to gonadal dose].
OBJECTIVE
The genetic risk for the offspring of patients treated with high doses of radioiodine was to be assessed with special regard to the gonadal dose caused by diagnostic and therapeutic procedures.


METHODS
41 young females (aged between 19 and 39 years) and four young males (aged 26 to 36 years) treated with radioiodine because of a thyroid carcinoma were interviewed by use of a questionnaire. The course of pregnancy and birth history could be documented as well as the congenital and developmental conditions of 56 children.


RESULTS
The amount of radioactivity applied for therapy and whole body scans ranged over 4.144 and 35.15 GBq 1-131; the individual gonadal dose was calculated based on the MIRD model and ranged over 0.2 and 2.2 Sv (0.51 Sv at a mean). The period of time between the last radioiodine application and confinement was at least 9 months, not exceeding 14 years. As to the course of pregnancy and birth two early abortions, one extrauterine gravidity and one premature birth due to an insufficiency of the placenta were stated. In one case a chromosomal translocation 7/14 occurred as a genetic defect which lead to an interruption. The children's development was unconspicuous except of two cases of neurodermatitis as well as multiple allergies and an early closure of the anterior fontanelle in one child each.


CONCLUSIONS
Although the genetic risk is supposed to increase with the gonadal dose achieved (doubling dose 1 Sv) and the increased risk of any congenital anomaly was calculated as about 13% at a mean in our patients, the rate of genetic determined diseases was not elevated (1.8% or 1/57). Thus, no increase of genetic defects or congenital malformations was reported in a total of 408 children described in the literature and in our group.
Ehrenheim
C
C
Abteilung Nuklearmedizin und spezielle Biophysik, Medizinischen Hochschule Hannover, Deutschland.
Hauswirth
C
C
Fitschen
J
J
Martin
E
E
Oetting
G
G
Hundeshagen
H
H
D000022:Abortion, Spontaneous; D000328:Adult; D002869:Chromosome Aberrations / Q000453:epidemiology*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007234:Infant, Premature; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008962:Models, Theoretical; D010053:Ovary / Q000528:radiation effects*; D010927:Placental Insufficiency; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011271:Pregnancy, Ectopic; D011879:Radiotherapy Dosage; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013737:Testis / Q000528:radiation effects*; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D013997:Time Factors; D014178:Translocation, Genetic
D007457:Iodine Radioisotopes