Inhibition of xylazine induced uterine contractility by clenbuterol and nifedipine.
A study was undertaken in order to determine the effects of xylazine on uterine contractility in goats premedicated with clenbuterol or nifedipine. These drugs inhibit uterine activity by acting as potent tocolytic or uterine relaxant agents. A balloon-tipped catheter was inserted under sedation and local anaesthesia on to a uterine horn in 15 cycling goats in order to record intrauterine pressure changes. Three groups of five goats were used: group I was treated with an intravenous dose of 0.1 mg kg-1 of xylazine. Groups II and III were pretreated with 4 micrograms kg-1 of clenbuterol and 80 micrograms kg-1 of nifedipine, respectively, before administrating the same dose of zylazine. Xylazine increased the frequency and intensity of uterine contractions significantly and the value of the area under the contraction curves was significantly higher than that observed under basal conditions i.e. before drug treatment. In goats premedicated with clenbuterol or nifedipine, the uterotonic effects of xylazine (2858 +/- 217 versus basal contractility: 1241 +/- 173 mm2.5 min-1, P < 0.05) were inhibited for the 30 minutes recording period. These data indicate that clenbuterol and nifedipine can be used as potent tocolytic agents in order to prevent the uterine side effects of xylazine.
Perez
R
R
Facultad de Medicina Veterinaria, Universidad de Concepcion, Chile.
Garcia
M
M
Arias
P
P
Gallardo
M
M
Valenzuela
S
S
Rudolph
M I
MI
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D002976:Clenbuterol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006041:Goats / Q000502:physiology*; D009543:Nifedipine / Q000494:pharmacology*; D013997:Time Factors; D015149:Tocolytic Agents / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology; D014599:Uterus / Q000187:drug effects / Q000502:physiology; D014991:Xylazine / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D015149:Tocolytic Agents; D014991:Xylazine; D009543:Nifedipine; D002976:Clenbuterol