title: Helicobacter pylori infection and gastric secretion in duodenal and gastric ulcer patients--the effect of eradication after one year.
abstract: The mechanism by which Helicobacter pylori (Hp) predisposes to duodenal and gastric ulcers remains still unclear. It is possible that Hp infection impaires gastric secretion. Evaluation of gastric acid and mucus secretion before and after Hp eradication would let to estimate the influence of Hp infection on gastric secretion. To evaluate the effect of Hp infection on gastric acid and gastric mucous secretion before and one year after Hp eradication. We examined 28 Hp positive peptic ulcer disease patients (10-gastric ulcer GU, 18-duodenal ulcer DU) before and one year after antibacterial treatment. Gastric acid output was examined basely (BAO) and in response to pentagastrin (6 micrograms/kg) (MAO) using Kay's standard method. Some components of gastric mucus as fucose, galactose, hexosamines and sialic acid were measured using calorimetric methods basaly and after pentagastrin stimulation. Plasma gastrin concentration was measured in 20 patients (6-GU, 14-DU) by radioimmunoassay before and one year after eradication. Hp status was determined by rapid urease test (CLO) and histology (Giemsa stain). One year after Hp successful eradication gastric acid secretion was significantly reduced-BAO: 3,31 vs 1,474 mmol/h; MAO: 19,63 vs 14,85 mmol/h, p < 0.05. Plasma gastrin concentration decreased significantly from 9,783 to 6,017 pmol/I, p < 0.05. In patients with ineffective eradication we did not observe any significant changes in gastric acid secretion. An evident, but not statistically significant, decrease of sialic acid output in eradicated patients was noted. The study has shown the significant influence of Hp infection on gastric acid secretion. Those results support the hypothesis that increased gastric acid secretion may be one of the pathogenic mechanism of Hp infection inducing mucosal damage.
authors.affiliation: Department of Gastroenterology, Medical Academy in Białystok, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Laszewicz
authors.forename: A
authors.initials: A
authors.lastname: Zaremba-Woroniecka
authors.forename: A
authors.initials: A
authors.lastname: Gabryelewicz
mesh_terms: D000293:Adolescent; D000328:Adult; D004381:Duodenal Ulcer / Q000097:blood / Q000378:metabolism*; D005260:Female; D005643:Fucose / Q000032:analysis; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D016481:Helicobacter Infections / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000737:chemistry; D019158:N-Acetylneuraminic Acid / Q000032:analysis; D013276:Stomach Ulcer / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005755:Gastrins; D005643:Fucose; D019158:N-Acetylneuraminic Acid