title: Effect of temperature on the solubility of desflurane, sevoflurane, enflurane and halothane in blood.
abstract: We have investigated the effect of temperature on the blood-gas solubility of desflurane, sevoflurane, enflurane and halothane. Blood was equilibrated with gas mixtures of known composition in open cuvette or closed flask tonometers over a temperature range of 29-39 degrees C, and the concentration of each anaesthetic in blood was measured at 37 degrees C by repeated headspace analysis using a gas chromatograph. Solubility increased by 5.4% of the solubility at 37 degrees C for each degree that equilibration temperature was reduced. This result was true for all anaesthetics in all blood samples, and is in keeping with results for other volatile anaesthetics.
authors.affiliation: Department of Anaesthesia, Hammersmith Hospital, London.
authors.forename: G G
authors.initials: GG
authors.lastname: Lockwood
authors.forename: S M
authors.initials: SM
authors.lastname: Sapsed-Byrne
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
mesh_terms: D018685:Anesthetics, Inhalation / Q000097:blood*; D000077335:Desflurane; D004737:Enflurane / Q000097:blood; D004987:Ethers / Q000097:blood; D006221:Halothane / Q000097:blood; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives / Q000097:blood; D008738:Methyl Ethers; D010313:Partial Pressure; D000077149:Sevoflurane; D012995:Solubility; D013696:Temperature
chemical_list: D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D004737:Enflurane; D000077335:Desflurane; D007530:Isoflurane; D006221:Halothane