title: Dobutamine stress echocardiography in the detection of coronary artery disease in a clinical practice setting.
abstract: In this prospective study, patients referred for coronary angiography for detection of disease underwent dobutamine stress echocardiography to define its value in a clinical practice setting.
  
  
  RESULTS
  Of 219 patients studied, 170 (78%) had significant coronary artery disease. The overall sensitivity and specificity of dobutamine stress echocardiography for coronary artery disease were 82 and 65%, respectively. The sensitivity was 88% for detection of triple-vessel disease, 83% for double-vessel disease, and 74% for single-vessel disease. Positive and negative predictive values for coronary artery disease were 89 and 51%, respectively. Dobutamine stress echocardiography correctly identified only 72 of 138 patients with significant stenosis of the left anterior descending coronary artery. In 219 patients, 345 of 657 major epicardial vessels had significant disease. Dobutamine stress echocardiography could only correctly identify the vessel involved in 188. Triple-vessel disease was present in 65 patients. Dobutamine stress echocardiography correctly categorised 18% (n = 12) of these. The remainder were incorrectly classified as having double-vessel disease or single-vessel disease (n = 45), or no disease at all (n = 8).
  
  
  CONCLUSIONS
  Dobutamine stress echocardiography performs well. However, lower specificity may lead to unwarranted referrals for coronary angiography, and the low NPV give false reassurance as to the absence of disease.
authors.affiliation: Cardiovascular Research Group, Mater Misericordiae Hospital, Dublin, Ireland.
authors.forename: T G
authors.initials: TG
authors.lastname: Hennessy
authors.forename: M B
authors.initials: MB
authors.lastname: Codd
authors.forename: C
authors.initials: C
authors.lastname: McCarthy
authors.forename: G
authors.initials: G
authors.lastname: Kane
authors.forename: H A
authors.initials: HA
authors.lastname: McCann
authors.forename: D D
authors.initials: DD
authors.lastname: Sugrue
mesh_terms: D000368:Aged; D002316:Cardiotonic Agents; D002932:Cineangiography; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D004280:Dobutamine; D004452:Echocardiography / Q000379:methods*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine