title: The effect of co-induction with midazolam upon recovery from propofol infusion anaesthesia.
abstract: Forty-eight patients undergoing day-case anaesthesia were asked to complete pre- and postoperative tests of psychomotor function in order to study the influence of co-induction with midazolam in conjunction with propofol/alfentanil anaesthesia on postoperative psychomotor recovery. The study was placebo controlled and double blind with patients receiving either 0.03 mg.kg-1 of midazolam or saline 2 min before induction of anaesthesia with propofol and alfentanil. Patients who underwent co-induction with midazolam had significantly impaired concentration and rapidity of response but improved accuracy and vigilance when compared with those who received saline. The study confirmed that co-induction with a subanaesthetic dose of midazolam reduced the induction dose of propofol by up to 50%. We conclude that co-induction with midazolam reduces psychomotor recovery in the immediate postoperative phase following propofol infusion anaesthesia.
authors.affiliation: Department of Anaesthesia, Nottingham City Hospital, UK.
authors.forename: K E
authors.initials: KE
authors.lastname: Tighe
authors.forename: J A
authors.initials: JA
authors.lastname: Warner
mesh_terms: D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000328:Adult; D000556:Ambulatory Surgical Procedures; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D011184:Postoperative Period; D015742:Propofol / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*
chemical_list: D000759:Adjuvants, Anesthesia; D018686:Anesthetics, Intravenous; D008874:Midazolam; D015742:Propofol