Craniopharyngiomas in two consanguineous siblings: case report.
OBJECTIVE
We describe a double case of craniopharyngioma in consanguineous siblings, suggesting the disease is sometimes genetic.


METHODS
Two typical adamantine craniopharyngiomas were observed in two consanguineous siblings. The brother and the sister, whose parents were first cousins, developed the tumors at the same age.


METHODS
The male patient was operated on using a frontopterional approach, and the tumor was completely resected. The patient remained free from recurrence 9 years after surgery. His older sister died after tumor removal was attempted at another institution.


CONCLUSIONS
To our knowledge, such a connection has never been reported in the literature. It suggests that craniopharyngioma, which is usually sporadic, can also be transmitted in an autosomal recessive manner.
Boch
A L
AL
Service de Neurochirurgie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
van Effenterre
R
R
Kujas
M
M
D000293:Adolescent; D002648:Child; D003241:Consanguinity; D003397:Craniopharyngioma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D006579:Heterozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009679:Nuclear Family; D010375:Pedigree; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D011336:Probability; D018570:Risk Assessment