title: Are pleural fluid parameters related to the development of residual pleural thickening in tuberculosis?
abstract: OBJECTIVE
  Identification of predictive factors for the development of residual pleural thickening (RPT).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  A 1,500-bed tertiary hospital.
  
  
  METHODS
  Patients with pleural tuberculosis diagnosed between December 1991 and February 1995 in our Respiratory Disease Service.
  
  
  METHODS
  The clinical and radiologic characteristics, and measurements of microbiological and biochemical parameters and markers in pleural fluid were studied. RPT was defined in a posteroanterior chest radiograph as a pleural space of >2 mm measured in the lower lateral chest at the level of an imaginary line intersecting the diaphragmatic dome.
  
  
  RESULTS
  In 56 patients studied, 11 (19.6%) had RPT 10 mm and 24 (42.8%) had RPT >2 mm. The pleural fluid of patients with RPT 10 mm had a significantly lower glucose concentration and pH and higher lysozyme and tumor necrosis factor-alpha levels than the other patients. The pleural fluid of patients with RPT >2 mm showed no significant differences.
  
  
  CONCLUSIONS
  The development of RPT 10 mm was related to higher concentrations of lysozyme and tumor necrosis factor-alpha and lower glucose concentration and pH in pleural fluid compared with development of lower measurements of RPT.
authors.affiliation: Respiratory Disease Service, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: de Pablo
authors.forename: V
authors.initials: V
authors.lastname: Villena
authors.forename: J
authors.initials: J
authors.lastname: Echave-Sustaeta
authors.forename: A L
authors.initials: AL
authors.lastname: Encuentra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D015415:Biomarkers; D005122:Exudates and Transudates / Q000166:cytology / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000378:metabolism*; D015588:Observer Variation; D010994:Pleura / Q000000981:diagnostic imaging; D010996:Pleural Effusion / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D011859:Radiography; D011863:Radioimmunoassay; D012189:Retrospective Studies; D013907:Thoracostomy; D014396:Tuberculosis, Pleural / Q000150:complications*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D000995:Antitubercular Agents; D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D009113:Muramidase; D005947:Glucose