Synthesis and antibacterial activities of new 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octan-2,4-dione moiety.
The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octane-2,4-dione moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bateria are determined and the effect of substituent on the bicyclic ring as well as stereoisomerism was investigated.
Nam
K H
KH
Division of Applied Science, Korea Institute of Science and Technology, Seoul, Korea.
Oh
C H
CH
Ham
Y W
YW
Lee
K S
KS
Cho
J H
JH
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D015780:Carbapenems