Vitamins and monothiols efficacy in the restoration of adenosine nucleotide degradation enzymes altered during methylmercury intoxication.
Male albino mice were intoxicated with a daily dose of 1 mg/kg of methylmercury chloride (MMC) for 7 days, and were treated thereafter with glutathione, N-acetyl-DL-homocysteine thiolactone, vitamin B complex, and vitamin E, either alone or in combinations, for the next 7 days. The animals were sacrificed on the eighth day, with the exception of one group that was kept without toxic exposure for an additional 7 days and sacrificed on the fifteenth day. Brain, spinal cord, kidney, and liver of the animals were examined for changes in adenosine deaminase and 5' nucleotidase. We found a severe inhibition of these enzymes during MMC intoxication and significant recovery during monothiols and vitamins administration, indicating the effectiveness of these agents in methylmercury detoxication.
Sood
P P
PP
Department of Bioscience, Saurashtra University, Rajkot, India.
Bapu
C
C
Vijayalakshmi
K
K
D015720:5'-Nucleotidase / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D005978:Glutathione / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008767:Methylmercury Compounds / Q000378:metabolism / Q000633:toxicity*; D051379:Mice; D013116:Spinal Cord / Q000187:drug effects* / Q000201:enzymology; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology; D014803:Vitamin B Complex / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*
D008767:Methylmercury Compounds; D013438:Sulfhydryl Compounds; D013876:Thiophenes; D014815:Vitamins; D014803:Vitamin B Complex; D014810:Vitamin E; C000486:citiolone; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase; D005978:Glutathione