[The receptor destroying enzyme of influenza viruses. The role of the receptor destroying enzyme on the budding and the release of influenza viruses from the host cells].
Influenza viruses encode two envelope glycoproteins, neuraminidase(NA) and hemagglutinin (HA), for which high resolution crystal structures are available. HA mediates attachment of the virus to the host cells and fusion with the endosomal membrane. NA (EC 3.2.1.18; sialidase, acyl neuraminylhydrolase) catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates and is presumably responsible for the elution of progeny virus. NA also cleaves a terminal sialic acid from the cellular receptors, and thus is described as a receptor-destroying enzyme. In this paper, recent advances on the structure and function of the influenza virus neuraminidase are described.
Suzuki
Y
Y
Department of Biochemistry, University of Shizuoka School of Pharmaceutical Sciences.
D015707:HN Protein; D009439:Neuraminidase / Q000502:physiology*; D009975:Orthomyxoviridae / Q000201:enzymology* / Q000502:physiology; D011991:Receptors, Virus / Q000378:metabolism*
D015707:HN Protein; D011991:Receptors, Virus; D009439:Neuraminidase