[Effects of AT-I on murine cytokins productions and NK cell activity in vivo].
Antitumor-I (AT-I) is a traditional Chinese medicine, which known to be combined with chemotherapeutic agent on antitumor effects. In this paper, the effections of AT-I on interleukin-2 (IL-2) and interleukin-6 (IL-6) was detected and NK cell activity were observed in normal and tumor-bearing BALB/c mice in vivo. The results showed that AT-I could enhance IL-2 and IL-6 production in normal mice, and IL-2 product in tumor-bearing mice. The results suggest that AT-I at a appropriate dose could modulate immunofunctions, so known as a biological response modifier (BRM).
Lei
X
X
Department of Pharmacology, School of Basic Medical Sciences, Chengdu.
Chu
Y
Y
D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007155:Immunologic Factors / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008419:Materia Medica / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D007155:Immunologic Factors; D007376:Interleukin-2; D015850:Interleukin-6; D008419:Materia Medica