[Effects of wound wet dressing with cerium nitrate on cell-mediated immunity after severe burn].
Suppression of cell-mediated immunity (CM) and lowering of survival rate follow major thermal injury are associated with absorption of burn toxin. Wistar rats received 30% full-thickness burn, and were then treated with early burn excision or wet dressing of cerium nitrate for the wound. At day 14 postburn, both survival rates and peripheral blood Th/Ts rate were monitored. It was found that both excision and cerium nitrate could prevent marked lowering of survival rate and Th/Ts ratio were monitored. It was found that both excision and cerium nitrate could prevent markly lowering of survival rates and Th/Ts ratio induced by severe burn. This indicated that CE, in the early postburn days, may replace early burn excision to prevent the suppression of CMI following severe burn.
Fang
Y
Y
Burn Center, Changhai Hospital, Second Military Medical University, Shanghai.
Chen
Y
Y
Wei
D
D
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000276:immunology; D016516:CD4-CD8 Ratio; D002563:Cerium / Q000627:therapeutic use*; D007111:Immunity, Cellular; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016176:T-Lymphocyte Subsets
D000891:Anti-Infective Agents, Local; C032786:cerium nitrate; D002563:Cerium