title: [Physiology and pathophysiology of the endothelin system in cardiovascular diseases].
abstract: The endothelins are a family of potent vasoconstrictors and mitogenic agents. Since the isolation of ET-1 in 1988 the worldwide scientific research interest has mushroomed, resulting in considerable knowledge about molecular biology, biochemistry and pharmacological actions of these peptides. A body of evidence has parallelly emerged pointing to their role in some physiological phenomena as well as in the pathophysiology of cardiovascular disease. The future therapeutic use of anti-endothelin strategies may offer clinical benefit in many of these conditions.
authors.affiliation: Abteilung Angiologie, Medizinische Hochschule Hannover.
authors.forename: I
authors.initials: I
authors.lastname: Wieczorek
authors.forename: H J
authors.initials: HJ
authors.lastname: Kruse
authors.forename: A
authors.initials: A
authors.lastname: Creutzig
mesh_terms: D002318:Cardiovascular Diseases / Q000503:physiopathology*; D019332:Endothelin-1 / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D017466:Receptors, Endothelin / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology*
chemical_list: D019332:Endothelin-1; D017466:Receptors, Endothelin