Synthesis and antibacterial evaluation of [1,3]benzothiazino[3,2-a]quinoline- and [3,1]benzothiazino[1,2-a]quinoline-6-carboxylic acid derivatives.
A series of [1,3]benzothiazino[3,2-a]quinoline- (5) and [3,1]benzothiazino[1,2-a]quinoline-6-carboxylic acids (10) were synthesized and evaluated for their in vitro antibacterial activity. The activity is discussed in terms of their structural features revealed by molecular orbital correlation.
Cecchetti
V
V
Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy.
Cruciani
G
G
Filipponi
E
E
Fravolini
A
A
Tabarrini
O
O
Xin
T
T
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D042462:4-Quinolones; D000890:Anti-Infective Agents; D013843:Thiazines