Mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Its binding motif for alpha 4 beta 7 and role in experimental colitis.
The integrin alpha 4 beta 7 and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) are molecules involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract. These molecules may play a complementary and significant role in animal models of colitis. We have investigated the structural interaction between alpha 4 beta 7 and MAdCAM-1. Site-directed mutagenesis studies of the MAdCAM-1 molecule has led to the identification of the amino acid residue (LDT) in the loop between beta strands C and D of the Ig-superfamily-like folds being involved in the adhesive and cell activation functions of MAdCAM-1 with alpha 4 beta 7.
Fong
S
S
Department of Immunology, Genentech, Inc., San Francisco, CA 94080-4990, USA. fong.sherman@gene.com
Jones
S
S
Renz
M E
ME
Chiu
H H
HH
Ryan
A M
AM
Presta
L G
LG
Jackson
D
D
D000595:Amino Acid Sequence; D000818:Animals; D015815:Cell Adhesion Molecules; D003092:Colitis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D016023:Integrins / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D008969:Molecular Sequence Data; D009088:Mucoproteins / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D016297:Mutagenesis, Site-Directed; D016201:Receptors, Lymphocyte Homing / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D013329:Structure-Activity Relationship
D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins; C504265:MADCAM1 protein, human; D009088:Mucoproteins; D016201:Receptors, Lymphocyte Homing; C071777:integrin alpha4beta7