DHFR gene point mutation as a predictor of Plasmodium falciparum resistance to cycloguanil in malaria cases from Africa imported to France.
Durand
R
R
Centre National de Référence pour la Chimiosensibilité du Paludisme, Hôpital Bichat-Claude Bernard, Paris, France. rjdurand@worldnet.fr
Ramiliarisoa
O
O
Sécardin
Y
Y
Eldin de Pécoulas
P
P
Basco
L K
LK
Le Bras
J
J
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D001216:Asparagine; D004351:Drug Resistance / Q000235:genetics; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics*; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D002727:Proguanil; D012694:Serine; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D014195:Travel; D014227:Triazines / Q000627:therapeutic use*
D000962:Antimalarials; D014227:Triazines; C026009:cycloguanil; D012694:Serine; D001216:Asparagine; D013762:Tetrahydrofolate Dehydrogenase; D002727:Proguanil