title: Incidence of risk of thromboembolism during treatment high-grade gliomas: a prospective study.
abstract: A prospective study of a series of 77 patients on adjuvant radiochemotherapy following surgery for high-grade gliomas was conducted to evaluate the risk of deep vein thrombosis and identify risk factors. We found a 20.8% risk of deep vein thrombosis at 12 months (standard error = 4.8%) and a 31.7% risk (standard error = 7.4%) at 24 months (Kaplan-Meier method). Twenty patients (26%) developed deep vein thrombosis with a maximum incidence within the first 7 months after surgery when chemotherapy was still being administered, often with corticosteroids. The risk factors identified were histology (glioblastoma versus anaplastic astrocytoma, P = 0.032, log rank test; 0.0485 L-ratio) and the presence of paresis (P = 0.010, log rank test; 0.0161 L-ratio). A borderline tendency was found for an association between the deep vein thrombosis site and the side of paresis (P = 0.103, Fisher's exact test). Four patients (5%) had massive pulmonary embolism, which was fatal in 3 (4%).
authors.affiliation: Dept. of Medical Oncology, Azienda Ospedaliera, Padova, Italy.
authors.forename: A A
authors.initials: AA
authors.lastname: Brandes
authors.forename: E
authors.initials: E
authors.lastname: Scelzi
authors.forename: G
authors.initials: G
authors.lastname: Salmistraro
authors.forename: M
authors.initials: M
authors.lastname: Ermani
authors.forename: C
authors.initials: C
authors.lastname: Carollo
authors.forename: F
authors.initials: F
authors.lastname: Berti
authors.forename: P
authors.initials: P
authors.lastname: Zampieri
authors.forename: C
authors.initials: C
authors.lastname: Baiocchi
authors.forename: M V
authors.initials: MV
authors.lastname: Fiorentino
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D005910:Glioma / Q000601:surgery / Q000628:therapy*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010291:Paresis / Q000150:complications; D011446:Prospective Studies; D012307:Risk Factors; D013923:Thromboembolism / Q000209:etiology* / Q000517:prevention & control
chemical_list: D005343:Fibrinolytic Agents; C006871:calcium heparin; D006493:Heparin