[The embryotoxic action of fragment C-I-6 of human interleukin-2].
The peptide C-I-6 is a modified fragment (sequence 59-72) of human interleukin-2 and stimulates regeneration of hepatic cells and tissues. Study of the possible embryotoxic and teratogenic properties of C-I-6 showed that in some cases it induces the following statistically significant changes: reduces the number of viable fetus, increases the occurrence of hydronephrosis and the number of external and internal hematomas, increases the weight and size of the embryo. It is concluded that intraperitoneal administration of C-I-6 causes a mild embryotoxic and teratogenic effect in rats.
Sukhareva
N N
NN
Sadovnikov
V B
VB
Mikhaleva
I I
II
Onoprienko
L V
LV
D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000633:toxicity*; D008297:Male; D010446:Peptide Fragments / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013047:Specific Pathogen-Free Organisms; D013723:Teratogens / Q000633:toxicity*; D013997:Time Factors
D007376:Interleukin-2; D010446:Peptide Fragments; D013723:Teratogens; C108495:peptide C-I-6