Radiochemical synovectomy.
Radiochemical synovectomies have been used for nearly fifty years for the treatment of persistent monoarticular synovitis refractory to antiinflammatory drugs, disease modifying drugs, and intraarticular corticosteroids. It is a therapeutic alternative to surgical synovectomy. There are controversies concerning safety, choice of appropriate agent, and logistics of administration. These concerns are discussed in addition to reviewing some of the more recent trials examining the efficacy of radiochemical synovectomy. It is clear that in properly selected patients this procedure is safe and beneficial.
Sholter
D
D
Davis
P
P
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000532:radiotherapy*; D006801:Humans; D007719:Knee Joint / Q000528:radiation effects*; D013256:Steroids; D013583:Synovial Membrane / Q000528:radiation effects; D013585:Synovitis / Q000532:radiotherapy*; D015021:Yttrium Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D013256:Steroids; D015021:Yttrium Radioisotopes