The effect of histamine on ion transport in porcine jejunum.
Histamine is present in the gastrointestinal tract, and is an important mediator in gastrointestinal type I hypersensitivity reactions. The effect of histamine on ion transport in "stripped" porcine jejunal preparations was investigated. Histamine caused a transient increase in short-circuit current (SCC), which seemed to be concentration dependent. A maximum response was obtained at 0.1 mM. The histamine response was attenuated (44.8%) by the neuronal conduction blocker, tetrodotoxin (TTX), indicating that enteric neurotransmitters are involved. The neurokinin-1 antagonist, CP 99,994, did not alter the response to histamine (0.1 mM). Thus, tachykinins acting at NK-1 receptors do not seem to be involved in the histamine response.
Thorbøll
J E
JE
Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Skadhauge
E
E
D000818:Animals; D006632:Histamine / Q000494:pharmacology*; D017136:Ion Transport / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism; D010880:Piperidines / Q000494:pharmacology; D013237:Stereoisomerism; D013552:Swine / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology
D010880:Piperidines; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine; D013779:Tetrodotoxin; D006632:Histamine