Laboratory studies in cross-species lung transplantation.
The lack of sufficient suitable human donor lungs for the many patients requiring pulmonary transplantation as life-saving therapy for end-stage lung diseases has generated extensive interest in cross-species lung transplantation. Ethical concerns and those of animal rights advocates have prompted studies of nonprimate species as potential solid organ donors for humans. This paper provides an overview of some of the laboratory studies of cross-species pulmonary transplantation performed over the past 20 years and focuses, in particular, on more recent work (from our laboratory and others) in the area of porcine-to-primate pulmonary xenotransplantation.
Kamholz
S L
SL
Department of Medicine, State University of New York Health Science Center at Brooklyn 11203-2098, USA.
Brewer
R J
RJ
Grijalva
G
G
Burack
J
J
Del Rio
M J
MJ
Vaynblatt
M
M
Lawson
N
N
Squinto
S
S
Fodor
W L
WL
Norin
A J
AJ
D000818:Animals; D030801:Animals, Genetically Modified; D018957:CD59 Antigens / Q000276:immunology; D004195:Disease Models, Animal; D006085:Graft Survival; D006801:Humans; D016040:Lung Transplantation / Q000276:immunology* / Q000379:methods / Q000473:pathology; D010215:Papio; D012131:Respiratory Insufficiency / Q000601:surgery; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology* / Q000379:methods / Q000473:pathology
D018957:CD59 Antigens