[Hepatoid adenocarcinoma of the stomach. Case report and review of the literature].
Hepatoid adenocarcinoma of the stomach is an uncommon gastric tumor. A throughout search of the literature revealed only 86 cases: the first case was reported by Bourreille et al in 1970. We describe a patient with primary gastric adenocarcinoma with high serum alpha-fetoprotein (AFP) levels (7000 ng/ml). Histologically foci strongly resembling hepatocellular carcinoma with hyaline globules were noted. Immunoreactivity for alpha-fetoprotein (AFP), a1 antitrypsin and CEA also indicate hepatocellular differentiation. This case provides informations on the DNA content and Ki67 expression of this unusual and aggressive variant of gastric adenocarcinoma.
Antonini
C
C
Servizio di Anatomia e Istologia patologica, ULSS 10 Veneto Orientale Ospedale di S. Donà di Piave, Venezia.
Forgiarini
O
O
Chiara
A
A
Briani
G
G
Sacchi
G
G
D000230:Adenocarcinoma / Q000097:blood / Q000737:chemistry / Q000473:pathology*; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002454:Cell Differentiation; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D013274:Stomach Neoplasms / Q000097:blood / Q000737:chemistry / Q000473:pathology*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D004273:DNA, Neoplasm; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D000515:alpha 1-Antitrypsin; D000509:alpha-Fetoproteins