title: [Hypersensitivity reactions to use of mebeverine].
abstract: Twenty-one cases of adverse reactions to mebeverine use were reported to the Inspectorate for Health Care in the Netherlands since 1978. In 12 patients (five men and seven women) this was an immunological hypersensitivity reaction. All patients recovered after drug withdrawal. The time between start and onset of symptoms varied from several minutes to 14 days. Most reactions consisted of urticaria or maculopapular rash, sometimes accompanied by fever, polyarthritis, thrombopenia or angioedema. In contradiction to the manufacturer's claims adverse reactions to the use of mebeverine do occur.
authors.affiliation: Inspectie voor de Gezondheidszorg, sectie Geneesmiddelenbewaking, Rijswijk.
authors.forename: B A
authors.initials: BA
authors.lastname: in 't Veld
authors.forename: E
authors.initials: E
authors.lastname: van Puyenbroek
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010627:Phenethylamines / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D010627:Phenethylamines; C005096:mebeverine