title: [The neurobiological bases of epileptogenesis in the developing brain].
abstract: The basics of neurophysiological, neurochemical and molecular mechanisms of epileptogenesis in early ontogeny are discussed. The role of developmental neuropathology, synaptogenesis; the role of glutamatergic and GABA-ergic transmitter systems are summarized. The candidates of genes in the childhood epilepsies, developmental changes in the expression of genes of voltage-gated ionic channels and receptor genes are reviewed.
authors.forename: S A
authors.initials: SA
authors.lastname: Chepurnov
authors.forename: N E
authors.initials: NE
authors.lastname: Chepurnova
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000196:embryology / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D018846:Excitatory Amino Acids / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology; D006801:Humans; D007696:Kindling, Neurologic / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D009474:Neurons / Q000502:physiology; D017470:Receptors, Glutamate / Q000235:genetics / Q000502:physiology; D013569:Synapses / Q000502:physiology
chemical_list: D018846:Excitatory Amino Acids; D017470:Receptors, Glutamate