title: Pancreatic carcinoma associated with the Leser-Trélat sign.
abstract: A case of pancreatic carcinoma associated with the Leser-Trélat sign is reported. A 53-yr-old male had complained of mild epigastric discomfort and back pain accompanied by seborrheic keratoses, which had increased in size and number over the previous 6 mo. A tumor was detected in the head of the pancreas and macroscopically curatively resected. His skin lesions diminished after surgery, but progressed again when the tumor recurred. Immunohistology for EGF showed a low level in the pancreatic carcinoma cells but a higher EGF content was recognized in the hyperkeratinized portions of the seborrheic keratoses. Of 130 underlying malignancies described in the 125 reported patients with the Leser-Trélat sign, neoplasms of the gastrointestinal tract were most common, comprising 47.7% of the total. The present case is the third case showing an association between a pancreatic carcinoma and the Leser-Trélat sign, but the first case for which the tumor of the pancreas was diagnosed in an early stage and resected surgically, as a result of the suggestive nature of this sign.
authors.affiliation: Department of Surgery, Matsusaka Chuo Hospital, Mie, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ohashi
authors.forename: N
authors.initials: N
authors.lastname: Hidaka
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D004815:Epidermal Growth Factor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D017492:Keratosis, Seborrheic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D004815:Epidermal Growth Factor