title: Salicylate and quinine affect the central nervous system.
abstract: Spontaneous local field potential (LFP) spindle frequencies in cat primary auditory cortex (AI) were estimated from the LFP-trigger autocorrelogram before and after application of sodium salicylate and quinine sulfate. A significant decrease (from 8.7 Hz to 7.6 Hz) was observed. The best modulation frequencies for 251 single units recorded in AI response to periodic click train stimulation also decreased (from 10 Hz to 8.6 Hz) after application of these tinnitus-inducing drugs. The results strongly suggest a central effect of salicylates and quinine in addition to their peripheral ototoxic effects.
authors.affiliation: Department of Psychology, The University of Calgary, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Kenmochi
authors.forename: J J
authors.initials: JJ
authors.lastname: Eggermont
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D001303:Auditory Cortex / Q000187:drug effects* / Q000503:physiopathology; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects* / Q000503:physiopathology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D034381:Hearing Loss / Q000139:chemically induced; D011803:Quinine / Q000633:toxicity*; D012980:Sodium Salicylate / Q000633:toxicity*; D014012:Tinnitus / Q000139:chemically induced
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011803:Quinine; D012980:Sodium Salicylate