title: Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.
abstract: A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.
authors.affiliation: Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, Baltimore, MD 21218, U.S.A.
authors.forename: G H
authors.initials: GH
authors.lastname: Posner
authors.forename: P
authors.initials: P
authors.lastname: Ploypradith
authors.forename: W
authors.initials: W
authors.lastname: Hapangama
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: J N
authors.initials: JN
authors.lastname: Cumming
authors.forename: P
authors.initials: P
authors.lastname: Dolan
authors.forename: T W
authors.initials: TW
authors.lastname: Kensler
authors.forename: D
authors.initials: D
authors.lastname: Klinedinst
authors.forename: T A
authors.initials: TA
authors.lastname: Shapiro
authors.forename: Q Y
authors.initials: QY
authors.lastname: Zheng
authors.forename: C K
authors.initials: CK
authors.lastname: Murray
authors.forename: L G
authors.initials: LG
authors.lastname: Pilkington
authors.forename: L R
authors.initials: LR
authors.lastname: Jayasinghe
authors.forename: J F
authors.initials: JF
authors.lastname: Bray
authors.forename: R
authors.initials: R
authors.lastname: Daughenbaugh
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds