title: A prospective, randomized, cross-over comparison of two methods of artificial insemination by donor on the incidence of conception: intracervical insemination by straw versus cervical cap.
abstract: In a prospective, randomized study of insemination with donor semen, intracervical insemination by straw was compared with insemination using a cervical cap with an intracervical reservoir. A total of 91 patients completed 486 treatment cycles. There were no significant differences in age, parity, indication for insemination by donor, or method of cycle monitoring between women who became pregnant and those who did not conceive with either insemination method. In 236 standard intracervical insemination cycles, 14 patients became pregnant (5.9% per cycle), whereas 38 patients conceived in 250 cervical cap cycles (15.2% per cycle). Both the crude pregnancy rates and the cumulative pregnancy rates calculated by the Kaplan-Meier life-table method were significantly different (chi(2)-test, P < 0.001, and log-rank test, P < 0.005 respectively). Pregnancy rates in artificial insemination with cryopreserved donor semen may be improved by the use of a cervical cap when compared to cervical insemination by straw. The use of the cervical cap may prolong the exposure of the spermatozoa to the cervical mucus and prevent the backflow of semen into the vagina.
authors.affiliation: Department of Obstetrics and Gynaecology, O.L. Vrouwe Gasthuis, Amsterdam, The Netherlands.
authors.forename: P A
authors.initials: PA
authors.lastname: Flierman
authors.forename: H V
authors.initials: HV
authors.lastname: Hogerzeil
authors.forename: D J
authors.initials: DJ
authors.lastname: Hemrika
mesh_terms: D001831:Body Temperature; D002584:Cervix Uteri; D018592:Cross-Over Studies; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007316:Insemination, Artificial, Heterologous / Q000295:instrumentation / Q000379:methods*; D007986:Luteinizing Hormone / Q000652:urine; D008297:Male; D010061:Ovulation Detection; D017060:Patient Satisfaction; D011247:Pregnancy; D011446:Prospective Studies; D012662:Semen Preservation
chemical_list: D007986:Luteinizing Hormone