title: Prevalence of infection with dengue virus among international travelers.
abstract: BACKGROUND
  Dengue has been recognized as a potential hazard to tourists. A prospective, controlled study in the outpatient clinic of a German infectious disease clinic was conducted to assess the prevalence of dengue virus infection among international travelers.
  
  
  METHODS
  Serum samples from 130 patients with signs or recent history clinically compatible with dengue (fever, headache, muscle and joint pain, or rash), 95 matched controls with diarrhea, and 26 patients who never visited a country endemic for dengue were investigated.
  
  
  RESULTS
  Nine (6.9%) of the 130 patients with compatible symptoms and 1 (1%) of the 95 controls with diarrhea developed rising antibody titers against dengue virus. Of these 10 patients with probable dengue infection, 6 had been to Thailand, 2 to Malaysia, and 1 each to Indonesia and Brazil.
  
  
  CONCLUSIONS
  Infection with dengue virus appears to be a realistic threat to travelers to Southeast Asia. Symptoms commonly associated with dengue, such as fever, myalgia, arthralgia, and vomiting, can be helpful for diagnosis when present, but the absence of typical symptoms does not exclude infection.
authors.affiliation: Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Jelinek
authors.forename: G
authors.initials: G
authors.lastname: Dobler
authors.forename: M
authors.initials: M
authors.lastname: Hölscher
authors.forename: T
authors.initials: T
authors.lastname: Löscher
authors.forename: H D
authors.initials: HD
authors.lastname: Nothdurft
mesh_terms: D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D003715:Dengue / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D014195:Travel / Q000706:statistics & numerical data*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G