title: Electron-microscopic study of MAOB-containing structures in the nucleus accumbens shell: using MAOA-deficient transgenic mice.
abstract: MAOB-containing structures in the nucleus accumbens were ultrastructurally studied for the first time, using MAOA-deficient transgenic mice and MAO enzyme histochemistry. Among the striatal structures, the nucleus accumbens, and in particular its dorsal shell, showed the strongest MAOB activity. MAOB-active cell bodies were embedded in a dense MAOB-active fiber plexus. MAOB-positive terminals formed axo-dendritic synapses which were exclusively of the asymmetric type. It is suggested that dopamine in the nucleus accumbens shell is transported into MAOB-positive fibers where it is degraded by MAOB.
authors.affiliation: Département de Médecine Expérimentale, INSERM U52, CNRS ERS 5645, Université Claude Bernard, Lyon, France. kikemoto@fujita-hu.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Ikemoto
authors.forename: K
authors.initials: K
authors.lastname: Kitahama
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: Y
authors.initials: Y
authors.lastname: Tokunaga
authors.forename: J L
authors.initials: JL
authors.lastname: Valatx
authors.forename: E
authors.initials: E
authors.lastname: De Maeyer
authors.forename: I
authors.initials: I
authors.lastname: Seif
mesh_terms: D000818:Animals; D001369:Axons / Q000201:enzymology* / Q000648:ultrastructure; D003712:Dendrites / Q000201:enzymology* / Q000648:ultrastructure; D005260:Female; D007527:Isoenzymes / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008854:Microscopy, Electron; D008995:Monoamine Oxidase / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*; D009411:Nerve Endings / Q000201:enzymology* / Q000648:ultrastructure; D009714:Nucleus Accumbens / Q000201:enzymology* / Q000648:ultrastructure; D013569:Synapses / Q000201:enzymology / Q000648:ultrastructure; D013572:Synaptic Vesicles / Q000201:enzymology / Q000648:ultrastructure
chemical_list: D007527:Isoenzymes; D008995:Monoamine Oxidase