title: Treatment of early AIDS dementia in intravenous drug users: high versus low dose peptide T.
abstract: This placebo-controlled, double blind, cross-over study tested the efficacy of two different doses of Peptide T in the treatment of nine intravenous drug users with early AIDS dementia who were also receiving methadone and AZT. Subjects received Peptide T doses of either 15 or 1.5 mg daily for four weeks. Neuropsychological performance improved in four of five patients treated with the high dose, but at the lower dose, three of four patients showed no improvement on Peptide T when compared with placebo. When subjects who received the high dose were compared with those who received the low dose, a significant dose effect was found only during the active phase of the trial even after correction for differences in level of functioning at baseline.
authors.affiliation: Department of Psychiatry, VA Connecticut (Psychiatry 116A), West Haven, CT 06516, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Kosten
authors.forename: M I
authors.initials: MI
authors.lastname: Rosen
authors.forename: T L
authors.initials: TL
authors.lastname: McMahon
authors.forename: T P
authors.initials: TP
authors.lastname: Bridge
authors.forename: S S
authors.initials: SS
authors.lastname: O'Malley
authors.forename: R
authors.initials: R
authors.lastname: Pearsall
authors.forename: P G
authors.initials: PG
authors.lastname: O'Connor
mesh_terms: D015526:AIDS Dementia Complex / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D000328:Adult; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015717:Peptide T / Q000008:administration & dosage* / Q000627:therapeutic use*; D015819:Substance Abuse, Intravenous / Q000150:complications*
chemical_list: D015717:Peptide T