title: Synthesis and antimicrobial activity of new 1-benzylbenzimidazolium chlorides.
abstract: 1-Benzylbenzimidazole reacts with chloromethylalkyl ethers or sulfides or chloromethylcycloalkyl ethers to produce 3-alkoxymethyl-1-benzylbenzimidazolium or 3-alkylthiomethyl-1-benzylbenzimidazolium or 1-benzyl-3-cycloalkoxymethylbenzimidazolium chlorides in very good yields. All the 1-benzylbenimidazolium chlorides showed antimicrobial activity. The relationship between chemical structure and antimicrobial activity was analyzed by quantitative structure-activity relationships (QSAR).
authors.affiliation: Poznań University of Technology, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Pernak
authors.forename: A
authors.initials: A
authors.lastname: Arndt
authors.forename: B
authors.initials: B
authors.lastname: Brycki
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002712:Chlorides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D001562:Benzimidazoles; D002712:Chlorides