title: Current issues in living donor nephrectomy.
abstract: Of 96 consecutive renal transplants in 2 years, 50 (52%) were living donor grafts. Donor demographics, treatment plans, length of stay (LOS), charges, and complications were reviewed. Donors included 27 women and 23 men aged 22 to 61 (mean 42.2) years; 33 were living related and 17 living unrelated donors. Racial distribution included 1 Hispanic, 2 Asian, 8 black, and 39 white donors. Pretransplant evaluation defined renal anatomy and function (minimal creatinine clearance 75 cc/min). Hospital admission occurred the morning of donation. Nephrectomy under general anesthesia entailed an anterior flank, extra-retroperitoneal approach (no rib resection); and postoperative epidural pain control was standard. Progressive early ambulation and pulmonary self-care optimized recovery. The 50 donors were hospitalized for 2 (n = 7), 3 (n = 18), 4 (n = 15), 5 (n = 6), and 6-8 (n = 4) days (mean LOS: 3.74 +/- 0.17, range 2-8 days). The mean charge for donor hospitalization was $15,415 +/- $397 (range $10,808-$29,579). One major intraoperative hemorrhage required transfusion; 1 patient was readmitted for wound drainage and pneumonia treated medically. While 40 of 50 patients (80%) were hospitalized for 4 days or less, there was no readmission because of short hospital stay. One early graft loss (3 days) occurred from technical problems; all others gained excellent life sustaining function. Three additional kidneys failed from rejection, noncompliance, and systemic coagulopathy. One recipient died at 8 months (CVA) with normal renal function. Current strategies for successful living kidney donation are thorough patient and family education, ambulatory preoperative testing, morning of surgery admission, and discharge planning beginning before hospitalization. Excellent outcomes may be accompanied by a brief LOS, epidural pain management, and liberal use of willing and healthy related and unrelated living donors.
authors.affiliation: Department of Surgery, University of Florida Health Science Center, Jacksonville, USA.
authors.forename: K W
authors.initials: KW
authors.lastname: Jones
authors.forename: T G
authors.initials: TG
authors.lastname: Peters
authors.forename: R K
authors.initials: RK
authors.lastname: Charlton
authors.forename: B J
authors.initials: BJ
authors.lastname: Lenz
authors.forename: G W
authors.initials: GW
authors.lastname: Walker
authors.forename: S
authors.initials: S
authors.lastname: Repper
authors.forename: M J
authors.initials: MJ
authors.lastname: Crews
authors.forename: L E
authors.initials: LE
authors.lastname: Antonucci
authors.forename: E J
authors.initials: EJ
authors.lastname: Peters
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural; D000768:Anesthesia, General; D044466:Asian People; D044383:Black People; D016063:Blood Loss, Surgical; D003404:Creatinine / Q000652:urine; D004322:Drainage; D004434:Early Ambulation; D005260:Female; D006085:Graft Survival; D017722:Hospital Charges; D006760:Hospitalization / Q000191:economics; D006801:Humans; D007431:Intraoperative Complications; D007668:Kidney / Q000033:anatomy & histology / Q000502:physiology; D016030:Kidney Transplantation; D007902:Length of Stay; D019520:Living Donors; D008168:Lung / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects / Q000191:economics / Q000379:methods; D010149:Postoperative Pain / Q000517:prevention & control; D010343:Patient Admission; D010347:Patient Care Planning; D010359:Patient Readmission; D011014:Pneumonia / Q000188:drug therapy; D011183:Postoperative Complications; D012648:Self Care; D013530:Surgical Wound Infection / Q000601:surgery; D016896:Treatment Outcome; D044465:White People
chemical_list: D003404:Creatinine