[Effect of magnesium on postischemic reperfused myocardial mitochondria].
Isovolumic rat heart preparations were exposed to low flow ischemia (0.2 ml/min) for 60 min, followed by 30 min of reperfusion. The concentration of Mg2+ was maintained 1.2 mmol/L throughout the study in group 2, while increased to 15 mmol/L or depleted to zero during ischemia only in group 3 and group 1 respectively. High concentration Mg2+ showed a significantly protective effect on Ca-ATPase activity and synthesis ability of ATP in myocardial mitochondria, and decreased its calcium overload. Thus it appears that high concentration Mg2+ infusion may partially reverse postischemic reperfusion injury to heart.
Xu
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Department of Pathophysiology, Beijing Medical University.
Shi
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D000818:Animals; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000252:Calcium-Transporting ATPases; D008274:Magnesium; D002118:Calcium