Non-surgical treatment of abdominal aortic aneurysms.
Percutaneous placement of an endovascular stent, with and without coils, in the treatment of large AAA in animal models is feasible, safe and effective. The covered stent sealed off AAA immediately after stent placement, however, it interrupted blood flow into arteries in the area covered by the stent. The uncovered stent prevented further expansion of the aneurysm and also significantly decreased the incidence of rupture. The long-term patency of branch arteries by the uncovered stent supported the possibility of safely using this approach in humans. Furthermore, either covered stent or uncovered stent with additional coils have the potential for treatment of acute aneurysm rupture or leaking. Most importantly, the aneurysm lumen in our model was gradually replaced by collagen after stent placement which further reduces the risk of aneurysm rupture: and this healing process was enhanced by the addition of coils. If proven safe and effective for humans as well, this technique has the potential for substantially reducing the morbidity and mortality associated with AAA.
Ruiz
C E
CE
Department of Medicine, Loma Linda University Medical Center & Children's Hospital, Loma Linda University School of Medicine 92354-0200, USA.
Zhang
H P
HP
Whittaker
P
P
D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000628:therapy*; D019917:Blood Vessel Prosthesis Implantation; D004195:Disease Models, Animal; D004285:Dogs; D005240:Feasibility Studies; D006801:Humans; D015607:Stents