title: Splenic artery aneurysms in liver transplant patients. Liver Transplant Group.
abstract: OBJECTIVE
  The purpose of the study was to investigate the incidence of and risk factors for splenic artery aneurysms in liver transplant patients.
  
  
  METHODS
  Medical records and the pre- and 1-year postoperative angiograms of 337 liver transplant patients were reviewed to assess the presence and characteristics of these aneurysms.
  
  
  RESULTS
  Forty-five patients with aneurysms were identified (13%): 41 cases in 242 adult patients (17%) and four (4%) in 95 children (p<0.01). The female-to-male ratio was 2:1. The majority of the aneurysms (87%) were located in the distal third of the splenic artery and the majority (87%) of the patients presented multiple aneurysms. In patients without portal hypertension no aneurysms were identified, whereas in 16% of the patients with portal hypertension aneurysms were found (p<0.001). In adult patients the incidence of splenic artery aneurysms was significantly higher in patients with parenchymal diseases than in patients with cholestatic diseases (p<0.0001). Two patients (4%) died due to rupture of the aneurysms. Control angiographies, 1 year after liver transplantation, showed no changes in size and number of the aneurysms, and no new aneurysms were identified.
  
  
  CONCLUSIONS
  The incidence of splenic artery aneurysms in liver transplant patients is 13%. They are generally multiple and located in the distal third of the splenic artery. The incidence is higher in women and in patients with parenchymal liver disease and portal hypertension. The incidence of rupture was 4%.
authors.affiliation: Department of Surgery, University Hospital Groningen, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Kóbori
authors.forename: M J
authors.initials: MJ
authors.lastname: van der Kolk
authors.forename: K P
authors.initials: KP
authors.lastname: de Jong
authors.forename: P M
authors.initials: PM
authors.lastname: Peeters
authors.forename: I J
authors.initials: IJ
authors.lastname: Klompmaker
authors.forename: T
authors.initials: T
authors.lastname: Kok
authors.forename: E B
authors.initials: EB
authors.lastname: Haagsma
authors.forename: M J
authors.initials: MJ
authors.lastname: Slooff
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000783:Aneurysm / Q000453:epidemiology* / Q000473:pathology; D000792:Angiography; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000150:complications*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology* / Q000473:pathology; D012307:Risk Factors; D012737:Sex Factors; D013157:Splenic Artery / Q000503:physiopathology*