Role and regulation of phospholipase D activity in normal and cancer cells.
PLD is regulated by the small GTP binding proteins Rho and Arf, though predominantly by the latter. The PA product of PLD activation is an activator of Rho-regulated actin stress fibre formation and in invasive cells of MMP-9 synthesis and activation. Together this may explain the increased invasion of cells in response to PA.
Wakelam
M J
MJ
Institute for Cancer Studies, University of Birmingham, U.K.
Martin
A
A
Hodgkin
M N
MN
Brown
F
F
Pettitt
T R
TR
Cross
M J
MJ
De Takats
P G
PG
Reynolds
J L
JL
D020727:ADP-Ribosylation Factors; D000199:Actins / Q000378:metabolism; D015153:Blotting, Western; D002462:Cell Membrane / Q000201:enzymology; D002465:Cell Movement / Q000502:physiology; D004492:Edetic Acid / Q000494:pharmacology; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000378:metabolism* / Q000494:pharmacology; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism; D018922:HL-60 Cells; D006801:Humans; D008055:Lipids / Q000032:analysis; D008666:Metalloendopeptidases / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism / Q000494:pharmacology; D010739:Phospholipase D / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein
D000199:Actins; D008055:Lipids; D010712:Phosphatidic Acids; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D004492:Edetic Acid; D010739:Phospholipase D; D008666:Metalloendopeptidases; D019204:GTP-Binding Proteins; D020727:ADP-Ribosylation Factors; D020742:rhoA GTP-Binding Protein