title: Revising messages traveling along the cellular information superhighway.
abstract: Cells use RNA messages to carry instructions from the genome to ribosomes about the types of proteins that should be made. These messages are generally revised by splicing before translation. Engineering ribozymes that can use splicing to repair mutant transcripts may be a useful approach to gene therapy of several genetic diseases.
authors.affiliation: Department of Experimental Surgery, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Sullenger
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D005818:Genetic Engineering; D015316:Genetic Therapy; D016678:Genome; D006801:Humans; D014176:Protein Biosynthesis; D012326:RNA Splicing / Q000502:physiology*; D016337:RNA, Catalytic / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D012333:RNA, Messenger / Q000502:physiology*; D012270:Ribosomes / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D016337:RNA, Catalytic; D012333:RNA, Messenger