title: Localization of hepatocyte growth factor and tubulointerstitial lesions in IgA nephropathy.
abstract: To investigate the relationship between localization of hepatocyte growth factor (HGF) and tubulointerstitial lesions (TILs) in the cortical area of renal biopsy specimens, a clinicopathological study was performed in 35 patients with IgA nephropathy. HGF was detected by an enzyme-antibody method and TILs were assessed semiquantitatively by light microscopy. HGF was observed mainly on epithelial cells in the tubules, but not in the glomeruli. Fourteen patients had biopsies that were positive for HGF. There was a correlation between HGF positivity and histological damage, the TIL grade, and several clinical parameters determined at biopsy. Thus, HGF is related to TILs in IgA nephropathy, and may be a factor in the exacerbation of this disease.
authors.affiliation: Second Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima City, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Yorioka
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Xue-Feng
authors.forename: T
authors.initials: T
authors.lastname: Nishiki
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Yamakido
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005355:Fibrosis; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D017228:Hepatocyte Growth Factor / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007672:Kidney Cortex / Q000378:metabolism* / Q000648:ultrastructure; D007684:Kidney Tubules / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D010784:Photomicrography
chemical_list: D017228:Hepatocyte Growth Factor