Relationship between antibody to cytotoxin and Helicobacter pylori infection.
Broth culture supernatants from 14 (34%) out of the 41 H. pylori strains tested, induced vacuolization in Intestine 407 cells in titers ranging from 1:2 to 1:64. 20% of H. pylori strains isolated from children and 42% of strains isolated from adults expressed vacuolating activity. Serum antibody to cytotoxin produced by H. pylori was detected with a neutralization assay. Anticytotoxic antibodies were present in all sera from patients infected with cytotoxic H. pylori strains. The toxin-neutralizing activity of sera from individuals infected with H. pylori suggests that the cytotoxin is produced in vivo.
Gościniak
G
G
Department of Microbiology, University of Medicine, Wrocław, Poland.
Przondo-Mordarska
A
A
Poniewierka
E
E
Iwańczak
B
B
Bilska
A
A
D000328:Adult; D000917:Antibody Formation; D001427:Bacterial Toxins / Q000276:immunology*; D002648:Child; D005756:Gastritis / Q000382:microbiology; D016481:Helicobacter Infections / Q000097:blood / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D009500:Neutralization Tests
D001427:Bacterial Toxins