Hedgehog signalling: Ci complex cuts and clasps.
Hedgehog (Hh) signalling in Drosophila inhibits partial proteolysis of the transcription factor Cubitus interruptus (Ci), and the ability of a complex containing Ci and the kinesin-related protein Costal-2 to bind microtubules. These changes are proposed to turn Ci from a repressor to an activator of Hh-target genes.
Kalderon
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Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004330:Drosophila / Q000378:metabolism*; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins / Q000378:metabolism*; D016547:Kinesins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C092937:ci protein, Drosophila; C107452:cos protein, Drosophila; C077245:hh protein, Drosophila; C085770:fu protein, Drosophila; D017346:Protein Serine-Threonine Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D016547:Kinesins