[Radiotherapy of cancer of the uterine cervix and successive appearance of new malignant growth in the irradiated field].
Among the late complications of high-dosage pelvic radiotherapy for cervical cancer, anorectal and bladder malignancies are sporadically reported in the literature. In this study the possible relationships of previous radiotherapy with late appearance of neoplasms are analyzed and in particular post-radiotherapy interval, dosage and type or irradiation to the cervical area. The mechanisms or neoplastic transformation or irradiated tissues are also studied. Three clinical cases or women irradiated in the past because or cervical cancer and recently treated at our surgical Division for the appearance or four new pelvic malignancies in the irradiated field (three rectal and one bladder cancer are presented. In conclusion, the possible cause-effect relationships between previous radiotherapy and subsequent appearance of neoplasms are analyzed as well as the potential therapeutical consequences or considering these women high-risk subjects. The usefulness or recruiting women with history or previous radiotherapy for cervical cancer in a strict follow-up program (ultrasonography, cytology and endoscopy) is suggested in order to make an early diagnosis of the new pelvic malignancy with a better possibility or treatment.
Russo
F
F
Dipartimento di Chirurgia, Università degli Studi di Roma Tor Vergata.
Spina
C
C
Coscarella
G
G
Sileri
P P
PP
Arturi
A
A
Stolfi
V M
VM
D000230:Adenocarcinoma / Q000473:pathology; D018253:Adenoma, Villous / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010386:Pelvic Neoplasms / Q000556:secondary*; D011832:Radiation Injuries / Q000150:complications / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*