title: Renal reserve is normal in adults born with unilateral renal agenesis and is not related to hyperfiltration or renal failure.
abstract: This study was carried out to examine the renal hemodynamic response in adult patients with single kidneys born with unilateral renal agenesis. A group of 21 patients with unilateral renal agenesis were divided into three groups according to their glomerular filtration rate (GFR): 112 +/- 3 ml/min x 1.73 m2 in group A, 68 +/- 3.2 ml/min x 1.73 m2 in group B, and 40.7 +/- 3.3 ml/min x 1.73 m2 in group C. Mean arterial blood pressure was significantly higher in the patients of group C who were also proteinuric. The renal hemodynamic response to an oral protein load (2 g/kg of protein as beefsteak) was normal in all groups and unrelated to hyperfiltration or to renal failure and proteinuria. The study indicates that in patients with renal agenesis, the hemodynamic response to a protein challenge is similar to that of kidney donors, renal transplant recipients and uninephrectomized patients. The paper also demonstrates that the renal response to a protein challenge is inadequate to identify patients with renal agenesis who are at risk of developing renal disease. Finally, in renal agenesis with renal disease, creatinine clearance overestimated the GFR by an average of 32.7%.
authors.affiliation: Chair of Nephrology, Second University of Naples, Italy.
authors.forename: N G
authors.initials: NG
authors.lastname: De Santo
authors.forename: P
authors.initials: P
authors.lastname: Anastasio
authors.forename: L
authors.initials: L
authors.lastname: Spitali
authors.forename: D
authors.initials: D
authors.lastname: Santoro
authors.forename: D
authors.initials: D
authors.lastname: Capodicasa
authors.forename: E
authors.initials: E
authors.lastname: Cirillo
authors.forename: G
authors.initials: G
authors.lastname: Capasso
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007668:Kidney / Q000002:abnormalities*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D051437:Renal Insufficiency / Q000150:complications* / Q000503:physiopathology
chemical_list: D007328:Insulin; D003404:Creatinine