title: Preparation, antimicrobial evaluation, and mutagenicity of [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl]methanols , [5-tert-butyl-2-methylaminophenyl]-[1-methyl-5-nitro-1H-2-imidazo lyl]me thanol, and [2-hydroxyaryl]-[1-methyl-5-nitro-1H-2-imidazolyl] ketones.
abstract: Efficient preparations of the titled compounds are described, their antimicrobial activity and mutagenic properties being evaluated. Some of the studied compounds are nonmutagenic and present a MIC as low as some of the usual standards in the field.
authors.affiliation: Department of Chemistry, Universitat Autònoma de Barcelona, Spain.
authors.forename: Y
authors.initials: Y
authors.lastname: Arredondo
authors.forename: M
authors.initials: M
authors.lastname: Moreno-Mañas
authors.forename: R
authors.initials: R
authors.lastname: Pleixats
authors.forename: C
authors.initials: C
authors.lastname: Palacín
authors.forename: M M
authors.initials: MM
authors.lastname: Raga
authors.forename: J M
authors.initials: JM
authors.lastname: Castelló
authors.forename: J A
authors.initials: JA
authors.lastname: Ortiz
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology*; D000432:Methanol / Q000031:analogs & derivatives*; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D007659:Ketones; D009593:Nitroimidazoles; D000432:Methanol