Dissociable effects of cingulate and medial frontal cortex lesions on stimulus-reward learning using a novel Pavlovian autoshaping procedure for the rat: implications for the neurobiology of emotion.
The effects of quinolinic acid-induced lesions of the anterior cingulate, posterior cingulate, and medial frontal cortices on stimulus-reward learning were investigated with a novel Pavlovian autoshaping procedure in an apparatus allowing the automated presentation of computer-graphic stimuli to rats (T. J. Bussey, J. L. Muir, & T. W. Robbins, 1994). White vertical rectangles were presented on the left or the right of a computer screen. One of these conditioned stimuli (the CS+) was always followed by the presentation of a sucrose pellet; the other, the CS-, was never followed by reward. With training, rats came to approach the CS+ more often than the CS-. Anterior cingulate cortex-lesioned rats failed to demonstrate normal discriminated approach, making significantly more approaches to the CS- than did sham-operated controls. Medial frontal cortex-lesioned rats acquired the task normally but had longer overall approach latencies. Posterior cingulate cortex lesions did not affect acquisition.
Bussey
T J
TJ
Department of Experimental Psychology, University of Cambridge, England.
Everitt
B J
BJ
Robbins
T W
TW
D000818:Animals; D001143:Arousal / Q000502:physiology*; D001245:Association Learning / Q000502:physiology; D001931:Brain Mapping; D003214:Conditioning, Classical / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D006179:Gyrus Cinguli / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000502:physiology; D009042:Motivation; D009949:Orientation / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology; D051381:Rats; D011930:Reaction Time / Q000502:physiology