Ovulation induction in a woman with premature ovarian failure resulting from a partial deletion of the X chromosome long arm, 46,X,del(X)(q22).
OBJECTIVE
To report successful ovulation induction in a woman with premature ovarian failure (POF) resulting from a partial Xq deletion.


METHODS
An uncontrolled study.


METHODS
University hospital.


METHODS
A 27-year-old woman with 46,X,del(X)(q22) who had hypergonadotropic secondary amenorrhea.


METHODS
Injections of hMG (225 IU/d) for 8 consecutive days after endogenous gonadotropin suppression with a long-acting GnRH agonist (900 micrograms/d) for 12 weeks, together with cyclic sex steroid replacement therapy.


METHODS
Serum concentrations of E2 and P as well as ultrasonography.


RESULTS
Folliculogenesis and ovulation.


CONCLUSIONS
Ovulation induction is possible in patients with POF caused by X chromosome aberrations.
Ishizuka
B
B
Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kawasaki, Japan.
Kudo
Y
Y
Amemiya
A
A
Ogata
T
T
D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D010062:Ovulation Induction; D016649:Primary Ovarian Insufficiency / Q000000981:diagnostic imaging / Q000235:genetics* / Q000628:therapy; D011374:Progesterone / Q000097:blood; D016896:Treatment Outcome; D014463:Ultrasonography; D014960:X Chromosome
D011374:Progesterone; D004958:Estradiol; D008596:Menotropins