A novel RNA-binding motif in influenza A virus non-structural protein 1.
The solution NMR structure of the RNA-binding domain from influenza virus non-structural protein 1 exhibits a novel dimeric six-helical protein fold. Distributions of basic residues and conserved salt bridges of dimeric NS1(1-73) suggest that the face containing antiparallel helices 2 and 2' forms a novel arginine-rich nucleic acid binding motif.
Chien
C Y
CY
Tejero
R
R
Huang
Y
Y
Zimmerman
D E
DE
Ríos
C B
CB
Krug
R M
RM
Montelione
G T
GT
D001665:Binding Sites; D019281:Dimerization; D009980:Influenza A virus / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D012313:RNA / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000378:metabolism
C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins; D012313:RNA