Induction of apoptosis by herpes simplex virus type 1.
Although herpes simplex virus type 1 (HSV-1) does not induce apoptosis in infected HEp-2 cells, in the presence of cycloheximide infection induced apoptosis with characteristic morphological changes as well as endonucleosomal DNA cleavage. The induction of apoptosis without de novo protein synthesis suggests that a structural protein of the HSV-1 virion is responsible for the observed apoptosis.
Koyama
A H
AH
Department of Virology, School of Medicine, The University of Tokushima, Japan. koyama@basic.med.tokushima-u.ac.jp
Adachi
A
A
D017209:Apoptosis; D002460:Cell Line; D006561:Herpes Simplex / Q000473:pathology*; D018259:Herpesvirus 1, Human / Q000502:physiology; D006801:Humans; D015678:Viral Structural Proteins / Q000502:physiology*
D015678:Viral Structural Proteins