Identification of multiple sclerosis-associated genes.
Multiple sclerosis (MS) is a complex genetic trait. Analyses to identify genetic variants that increase susceptibility to MS have primarily focused on candidate genes, either in family linkage investigations or in association (linkage disequilibrium) studies in sporadic cases and control subjects. Most of the candidate genes considered to date either influence immune function or encode structural myelin proteins. Recently, three preliminary whole genomic surveys were completed, and they reveal multiple loci of possible genetic linkage that are worthy of further study. No convincing evidence for a single strong locus has emerged from analysis of the three studies. Linkage promises to focus the future choice of candidate genes for further investigation.
Hogancamp
W E
WE
Department of Neurology, Mayo Clinic Rochester, Minnesota 55905, USA.
Rodriguez
M
M
Weinshenker
B G
BG
D003165:Complement System Proteins / Q000235:genetics; D008040:Genetic Linkage; D016678:Genome; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D008928:Mitochondria / Q000235:genetics; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology*; D009154:Mutation; D004676:Myelin Basic Protein / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D006680:HLA Antigens; D007136:Immunoglobulins; D004676:Myelin Basic Protein; D011948:Receptors, Antigen, T-Cell; D014409:Tumor Necrosis Factor-alpha; D003165:Complement System Proteins