Periodontal inflammatory and cystlike lesions in BDF1 and B6C3F1 mice.
Periodontal inflammatory and cystlike lesions were detected in aged BDF1 and B6C3F1 mice. Lesions were unilateral, single, and located in the labial region of the incisor teeth. The largest cystlike lesion deformed the skull. Histologically, the cystlike lesions were classified into three types: predominantly an inflammatory reaction, predominantly a cyst formation, and a mixed lesion. These periodontal inflammatory and cystlike lesions were pathogenetically similar and were considered sequential changes; the lesions showing both cyst formation and inflammatory reaction seemed to be intermediate along a path toward formation of large cysts. The cysts probably were derived from periodontal tissue and developed as a result of inflammatory reaction to foreign bodies, including hair. The term "murine periodontal cyst" is proposed for this lesion. Detailed pathogenetic studies on murine odontogenic cystic lesions may be warranted.
Sakura
Y
Y
Division of Pathology, Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Kanagawa, Japan.
D000818:Animals; D005260:Female; D015994:Incidence; D007180:Incisor / Q000473:pathology; D008297:Male; D051379:Mice; D009296:Nasal Cavity / Q000473:pathology; D010509:Periodontal Cyst / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D010518:Periodontitis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D012376:Rodent Diseases / Q000453:epidemiology / Q000473:pathology*