[Reactive oxygen species produced by the addition of sepiolite and vermiculite (expanded or not) to suspensions of human polymorphonuclear phagocytes and bovine alveolar macrophages].
We have studied a sample of commercial sepiolite and two samples of commercial vermiculite, which are clay minerals advised to replace asbestos. We have in vitro tested their abilities to produce reacting oxygen species (ROS) after they have been added to suspension of human polymorphonuclear leukocytes and bovine alveolar macrophages. The behaviour of sepiolite and vermiculite have been compared with those of asbestos fibres given by Unione Internationale contre le Cancer (UICC) and with kaolin and illite. Sepiolite was not able to induce ROS production, while vermiculite was able to induce a relevant ROS generation, even if the values were always lower than that obtained from chrysotile. Kaolin was able to generate a high ROS production.
Amati
M
M
Clinica di Medicina del Lavoro, Università di Ancona, Ospedale Regionale di Torrette AN.
Visonà
I
I
Valentino
M
M
Scancarello
G
G
Governa
M
M
D000328:Adult; D000538:Aluminum Silicates / Q000494:pharmacology*; D000818:Animals; D001194:Asbestos / Q000494:pharmacology; D017638:Asbestos, Crocidolite / Q000494:pharmacology; D017632:Asbestos, Serpentine / Q000494:pharmacology; D002417:Cattle; D002478:Cells, Cultured; D006801:Humans; D007616:Kaolin / Q000494:pharmacology; D008163:Luminescent Measurements; D008262:Macrophage Activation / Q000187:drug effects*; D016676:Macrophages, Alveolar / Q000187:drug effects*; D017633:Magnesium Silicates / Q000494:pharmacology*; D008903:Minerals / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016897:Respiratory Burst / Q000187:drug effects*
D000538:Aluminum Silicates; D017632:Asbestos, Serpentine; D017633:Magnesium Silicates; D008903:Minerals; D017382:Reactive Oxygen Species; D017638:Asbestos, Crocidolite; C099089:illite; C003760:vermiculite; D001194:Asbestos; D007616:Kaolin; C001671:magnesium trisilicate