Immunohistochemical detection of the melanocortin 1 receptor in human testis, ovary and placenta using specific monoclonal antibody.
We describe the immunohistochemical detection of the melanocortin 1 receptor (MC1R) protein in human gonadal tissues using a specific monoclonal antibody. The MC1R was found to be present in Leydig's cells in testis, in lutein cells in the corpus luteum and in the nucleus of the trophoblastic cells of the placenta. Though it has been speculated earlier that MC1R is present in gonadal tissues, this is the first report demonstrating the presence of MC1R protein in these cells.
Thörnwall
M
M
Department of Pharmaceutical Bioscience, Biomedical Centre, University Hospital, Uppsala, Sweden.
Dimitriou
A
A
Xu
X
X
Larsson
E
E
Chhajlani
V
V
D000911:Antibodies, Monoclonal; D002467:Cell Nucleus / Q000737:chemistry; D005260:Female; D006066:Gonads / Q000737:chemistry* / Q000166:cytology; D006801:Humans; D007150:Immunohistochemistry; D007985:Leydig Cells / Q000737:chemistry; D008184:Luteal Cells / Q000737:chemistry; D008297:Male; D010920:Placenta / Q000737:chemistry* / Q000166:cytology; D018043:Receptors, Corticotropin / Q000032:analysis* / Q000276:immunology; D044101:Receptors, Melanocortin; D014327:Trophoblasts / Q000737:chemistry
D000911:Antibodies, Monoclonal; D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin