title: [Hemo-lymphopoietic tumors in agriculture. Case-control study in an epidemiologic area of southern Bari].
abstract: In order to evaluate the association between hemolymphoietic tumors and agriculture, we are carrying out a case-control study in the southern province of Bari (Italy). In the period 1st July 1987-30 June 1989, seventy-one incident cases of limphomes, leukemias and multiple myeloma and three fold higher number of controls (other tumors) aged more than fourteen years old were selected. A structured questionnaire was carried out to collect informations, focusing attention to the use of pesticides. For the evaluation of the exposure to specific substances a crop exposure matrix with "multiple circumstantial determinants" (crops and/or type of breeding, phytopatologies, areas and time windows) will be used. In this update a specific pesticides analysis was not conducted. Therefore, we classified as exposed farmers, farm laboures, breeders and whoever affirmed the regular use of pesticides. Up to 1st July 1995, one hundred and seventy-three subjects were contacted. Twenty-three (13%) of them refused to participate to the study, one hundred and fifteen (87%) of them, thirty-one (21%) case and one hundred and nineteen (79%) controls, were interviewed. Nineteen (61%) of cases were males, twelve (39%) of cases were exposed; seventy-two (60.5%) of controls were males, fourty-five (38%) of controls were exposed. The risk of hemolymphoietic tumors associated with exposure was null (O.R. = 1.04; I.C. 95% = 0.42-2.50); no job category (farmer, farm labourer, breeder) was statistically significant associate with cases. An association with farmer (O.R. = 4.87; I.C. 95% - 1.12-20.52) and breeder (O.R. = 4.83; I.C. = 1.19-18.11) was statistically significant if those fourteen subjects with leukemia were considered as cases. Using a logistic model (which independent variables were age, sex, information gathered directly from the subject of from relatives and smoking habit) O.R. for leukemia and farmer resulted statistically significant (O.R. = 5.38; I.C. 95% = 1.31-21.99); instead a considerable decreased O.R. was observed for leukemia and breeder (O.R. = 1.20; I.C. 95% = 0.73-2.00). These results could be subject to variation after the next data input.
authors.affiliation: Dipartimento di Medicina Interna e del Lavoro, Sez. di Medicina del Lavoro, Università degli Studi di Bari.
authors.forename: G
authors.initials: G
authors.lastname: Assennato
authors.forename: G
authors.initials: G
authors.lastname: Tria
authors.forename: L
authors.initials: L
authors.lastname: Macinagrossa
authors.forename: M
authors.initials: M
authors.lastname: Ruggieri
authors.forename: A
authors.initials: A
authors.lastname: Porro
authors.forename: L
authors.initials: L
authors.lastname: Gervasio
authors.forename: G
authors.initials: G
authors.lastname: Laccone
mesh_terms: D000368:Aged; D000382:Agricultural Workers' Diseases / Q000139:chemically induced / Q000453:epidemiology*; D002273:Carcinogens / Q000009:adverse effects; D016022:Case-Control Studies; D005260:Female; D019337:Hematologic Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D006689:Hodgkin Disease / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007938:Leukemia / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology; D016273:Occupational Exposure; D009790:Occupations; D016017:Odds Ratio; D010575:Pesticides / Q000009:adverse effects
chemical_list: D002273:Carcinogens; D010575:Pesticides