title: Studies on the oxygen transport in the clinical association between Hb-S and Hb-C.
abstract: The whole blood oxygen affinity of a Negro carrier of SC disease was found to be characterized by some right-shifted p50 and clearly increased Bohr effect, whereas the isolated and purified Hb-S and Hb-C exhibited slight deficiencies mainly of the Bohr effect. The right-shifted p50 from whole blood can be easily explained by the mild anemia with a parallel increase of 2,3-diphosphoglycerate (DPG), whereas the functional discrepancies between whole blood function and that of the purified Hb-S and C could be due, at least in part, to the presence in vivo of consistent amounts of hybrid Hb tetramers of the type alpha alpha beta S beta C. Unfortunately, the mechanism promoting the formation (or dissolution) of hybrids are fundamentally unknown; so, either their presence and functional properties are very difficult to be explored.
authors.affiliation: Università degli Studi, Torino, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ricco
authors.forename: O
authors.initials: O
authors.lastname: David
authors.forename: M I
authors.initials: MI
authors.lastname: Parodi
authors.forename: S
authors.initials: S
authors.lastname: Bosio
authors.forename: P
authors.initials: P
authors.lastname: Scaravaglio
authors.forename: E
authors.initials: E
authors.lastname: Rabino-Massa
mesh_terms: D000328:Adult; D005260:Female; D006444:Hemoglobin C / Q000378:metabolism*; D006450:Hemoglobin SC Disease / Q000097:blood; D006451:Hemoglobin, Sickle / Q000378:metabolism*; D006801:Humans; D010100:Oxygen / Q000097:blood*
chemical_list: D006451:Hemoglobin, Sickle; D006444:Hemoglobin C; D010100:Oxygen