[The effect of the dioxin-containing herbicide 2,4-D on the hormonal status of experimental animals].
The article presents studies of hormonal state in rats under daily or 20-day peroral administration of variable doses of 2,4-D herbicide containing dioxine. Changed levels of thyroid hormones, insulin, cortisol, testosterone and estradiol appeared to be divergent and dose-dependent, proving direct toxic effects of the herbicide in endocrine organs, altered hormonal effects in target organs and disorders of peripheral hormonal metabolism.
Gil'manov
A Zh
AZh
Galimov
Sh N
ShN
Kamilov
F Kh
FKh
Davletov
E G
EG
Shchepanskiĭ
V O
VO
D015084:2,4-Dichlorophenoxyacetic Acid / Q000506:poisoning*; D000208:Acute Disease; D000818:Animals; D004147:Dioxins / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D004702:Endocrine Glands / Q000737:chemistry / Q000187:drug effects; D006540:Herbicides / Q000506:poisoning*; D006728:Hormones / Q000032:analysis*; D007928:Lethal Dose 50; D008297:Male; D011041:Poisoning / Q000378:metabolism; D051381:Rats
D004147:Dioxins; D006540:Herbicides; D006728:Hormones; D015084:2,4-Dichlorophenoxyacetic Acid