In vitro activities of an investigational quinolone, glycylcycline, glycopeptide, streptogramin, and oxazolidinone tested alone and in combinations against vancomycin-resistant Enterococcus faecium.
We evaluated the in vitro activities of clinafloxacin, CL331,002, LY333328, quinupristin dalfopristin, and eperezolid (formerly known as U-100,592) against four strains of enterococci. All regimens tested resulted in the growth inhibition of each isolate. Against the three clinafloxacin-susceptible strains, clinafloxacin tested alone was the most active treatment, decreasing the bacterial inoculum by more than 3 log10 CFU/ml after 24 h in time-kill curve studies.
Mercier
R C
RC
Department of Pharmacy Services, Detroit Receiving Hospital/University Health Center, College of Pharmacy and Allied Health Professions, Wayne State University, Michigan 48201, USA.
Penzak
S R
SR
Rybak
M J
MJ
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D016984:Enterococcus faecium / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014640:Vancomycin / Q000494:pharmacology
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004338:Drug Combinations; D014640:Vancomycin