Transcription control: repressed repeats express themselves.
Multi-copy transgenes are poorly expressed in plants, Drosophila and mammals; this repression is relieved by reducing copy number, leading to chromatin remodeling and transcriptional activation. Host defense mechanisms monitor repeated sequences in the genome, modulating their chromatin packaging and functional capabilities.
Wolffe
A P
AP
Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892-5431, USA. awlme@helix.nih.gov
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D005786:Gene Expression Regulation; D006801:Humans; D019476:Insect Proteins / Q000378:metabolism; D063150:Polycomb Repressive Complex 1; D012091:Repetitive Sequences, Nucleic Acid; D012097:Repressor Proteins / Q000378:metabolism; D014158:Transcription, Genetic; D014162:Transfection; D019076:Transgenes
D029721:Drosophila Proteins; D019476:Insect Proteins; C066770:Pc protein, Drosophila; D012097:Repressor Proteins; D063150:Polycomb Repressive Complex 1