Successful pregnancy after allogeneic bone marrow transplant with embryos isolated before transplant.
RESULTS
Autologous embryos from in vitro-fertilized ova were successfully implanted in a 29-year-old woman, 2 years after successful allogeneic bone marrow transplant (BMT) for chronic myeloid leukemia (CML). A second pregnancy, similarly initiated, is in progress at 4 years posttransplant.


CONCLUSIONS
Our experience offers a fertility-salvaging technique to some women after cytotoxic therapy, where time permits ovarian hyperstimulation before the need for definitive myeloblative therapy of their malignancy, and where the risk of subsequent infertility is high.
Lipton
J H
JH
Department of Medicine, Princess Margaret Hospital and University of Toronto, Ontario, Canada. jeffrey_lipton@pmh.toronto.on.ca
Virro
M
M
Solow
H
H
D000328:Adult; D016026:Bone Marrow Transplantation; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008297:Male; D011184:Postoperative Period; D011247:Pregnancy