title: Cat carotid body chemosensory responses to non-hypoxic stimuli are inhibited by sodium nitroprusside in situ and in vitro.
abstract: We studied the effects of sodium nitroprusside, a nitric oxide donor, on the chemosensory responses to cyanide and nicotine in the cat carotid body. In situ, sodium nitroprusside infusion reduced the cyanide-evoked responses in a dose-dependent manner. In vitro, Tyrode containing nitroprusside reversibly reduced the cyanide- (by 59%) and nicotine-induced (by 45%) chemosensory responses. The present results suggest that chemosensory responses induced by cyanide and nicotine are reduced by increased nitric oxide content, similarly to the hypoxic chemosensory responses.
authors.affiliation: Laboratorio de Neurobiología, Facultad de Ciencias, Universidad de Chile, Santiago. jalcayag@codon.ciencias.uchile.cl
authors.forename: J
authors.initials: J
authors.lastname: Alcayaga
authors.forename: R
authors.initials: R
authors.lastname: Iturriaga
authors.forename: J
authors.initials: J
authors.lastname: Ramirez
authors.forename: R
authors.initials: R
authors.lastname: Readi
authors.forename: C
authors.initials: C
authors.lastname: Quezada
authors.forename: P
authors.initials: P
authors.lastname: Salinas
mesh_terms: D000818:Animals; D002344:Carotid Body / Q000187:drug effects*; D002415:Cats; D002628:Chemoreceptor Cells / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005731:Ganglionic Stimulants / Q000494:pharmacology; D000860:Hypoxia; D008297:Male; D009538:Nicotine / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology*; D012966:Sodium Cyanide / Q000494:pharmacology
chemical_list: D005731:Ganglionic Stimulants; D009599:Nitroprusside; D009569:Nitric Oxide; D009538:Nicotine; D012966:Sodium Cyanide