title: Carquinostatin B, a new neuronal cell-protecting substance produced by Streptomyces exfoliatus.
abstract: Brain ischemia injury is elicited by the excitotoxicity of L-glutamate. Carquinostatin B was isolated from Streptomyces exfoliatus 2419-SVT2 as a potent neuroprotective substance which protests neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity. The structure of carquinostatin B was established principally by NMR studies to be a carbazole derivative with an ortho quinone function.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shin-ya
authors.forename: T
authors.initials: T
authors.lastname: Kunigami
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Furihata
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002477:Cells / Q000187:drug effects; D018698:Glutamic Acid / Q000633:toxicity; D006825:Hybridomas / Q000166:cytology; D009682:Magnetic Resonance Spectroscopy; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D002227:Carbazoles; D018696:Neuroprotective Agents; C111279:carquinostatin B; C041514:carbazole; D018698:Glutamic Acid