title: Measurement of synovial lining volume by magnetic resonance imaging of the knee in chronic synovitis.
abstract: OBJECTIVE
  Current methods of monitoring chronic synovitis in a single joint rely on clinical examination derived indices, such as the detection of synovial thickening. This study aimed to develop a reproducible method for quantifying the volume of synovial lining in chronic synovitis using contrast enhanced magnetic resonance (MR) imaging.
  
  
  METHODS
  The knees of 18 patients with chronic synovitis were examined (34 studies). A 2D T1 weighted FLASH sequence was used to evaluate the temporal enhancement of synovial structures after intravenous contrast. Synovial lining volume was calculated from subtraction of pre and post-enhancement 3D T1 weighted MP RAGE images with thresholding and pixel counting. Eleven patients were examined before and after intra-articular glucocorticoid (mean interval 14 weeks) and MR data compared with changes in clinical examination derived indices of disease activity.
  
  
  RESULTS
  Synovial lining volume varied from 52-267 ml. The coefficient of variation in volume calculation was 3.5% for a single observer and was 3.8% for two observers. Synovial lining volume was quantified in all patients where synovial lining thickening could not be detected clinically. A decrease in synovial lining volume of > 40% was associated with an improvement in synovial lining thickening, detected clinically. Decreases in synovial lining volume were quantified by MR in two of three patients where changes in clinical examination derived indices were inconsistent.
  
  
  CONCLUSIONS
  A reproducible method of estimating the volume of synovial lining in patients with chronic synovitis has been developed. MR measurement of synovial lining volume may quantify changes in chronic synovitis that remain unidentified by clinical measures.
authors.affiliation: Department of Medicine, University College London.
authors.forename: G
authors.initials: G
authors.lastname: Clunie
authors.forename: M A
authors.initials: MA
authors.lastname: Hall-Craggs
authors.forename: M N
authors.initials: MN
authors.lastname: Paley
authors.forename: A
authors.initials: A
authors.lastname: King
authors.forename: I D
authors.initials: ID
authors.lastname: Wilkinson
authors.forename: P J
authors.initials: PJ
authors.lastname: Ell
authors.forename: J C
authors.initials: JC
authors.lastname: Edwards
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007090:Image Interpretation, Computer-Assisted; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000473:pathology*; D013585:Synovitis / Q000473:pathology*