title: [Incidence of lesions described by magnetic resonance imaging in the clarification of focal epilepsy of frontal and temporal origin].
abstract: OBJECTIVE
  Today, MRI is an integral part of the presurgical evaluation of patients suffering from partial epilepsy. These patients frequently show focal morphological abnormalities with potential epileptogenic character and surgical resection of these lesions is associated with superior postsurgical outcome as to seizure frequency. Apart from easily detectable defects, such as post-traumatic lesions or cerebral infarction, as wide variety of mainly small abnormalities can be detected using MRI.
  
  
  METHODS
  In this study, 484 patients suffering from partial epilepsy of temporal or frontal onset were evaluated for the incidence of different lesions in this population.
  
  
  RESULTS
  All lesions found were included without evaluating their potential epileptogenicity, which remains to be proven using other procedures (EEG, SPECT, PET, etc.). Involvement of the hippocampal formation was a major finding in temporal lobe epilepsy, which could be detected as sclerosis (T2w-images), atrophy (T2w-TSE or T1w-IR-images) or both (15%). In addition and in declining frequency various tumors (14%), post-traumatic lesion (-5%), and focal cortical dysplasia or other disturbances of cortical integrity (-4%) were found. These lesions are detectable with best contrast on different sequences. As a consequence it is suggested to acquire sequences in 3 dimensions including a T1w-SE, two (coronal and axial) double-echo-SE sequences and similarly two T1w-IR-sequences. The application of contrast media can be restricted to special questions, derived either from the first imaging results or from the patients history.
  
  
  CONCLUSIONS
  Using qualitative data for interpretation, the sensitivity as to the detection of any focal pathology of a recent-generation MRI in this population was 75%, with 79% for temporal lobe epilepsies and 67% for frontal lobe epilepsies. Quantitative measurements of hippocampal volume or signal seem to be able to increase the sensitivity of the method.
authors.affiliation: Klinik und Poliklinik für Nuklearmedizin, Rheinischen Friedrich-Wilhelms Universität Bonn, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Menzel
authors.forename: F
authors.initials: F
authors.lastname: Grünwald
authors.forename: B
authors.initials: B
authors.lastname: Ostertun
authors.forename: L
authors.initials: L
authors.lastname: Solymosi
authors.forename: A
authors.initials: A
authors.lastname: Bockisch
authors.forename: J
authors.initials: J
authors.lastname: Gieseke
authors.forename: H
authors.initials: H
authors.lastname: Schild
authors.forename: C E
authors.initials: CE
authors.lastname: Elger
authors.forename: H J
authors.initials: HJ
authors.lastname: Biersack
mesh_terms: D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D002540:Cerebral Cortex / Q000473:pathology; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis* / Q000209:etiology; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000209:etiology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D012598:Sclerosis