Paternal age effect of YY aneuploidy in human sperm, as assessed by fluorescence in situ hybridization.
Sperm samples were collected from 18 healthy men of various ages. Multicolor FISH was performed on each sample, using probes for the sex chromosomes and chromosome 1. A minimum of 10,000 sperm per donor was analyzed. The Pearson correlation coefficient was used to determine if there was an association between donor age and disomy frequency for the sex chromosomes.
Kinakin
B
B
Department of Medical Genetics, University of Calgary, Alberta, Canada.
Rademaker
A
A
Martin
R
R
D000328:Adult; D000782:Aneuploidy; D004171:Diploidy; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D010331:Paternal Age; D013094:Spermatozoa / Q000648:ultrastructure*; D014960:X Chromosome; D014998:Y Chromosome