title: [Structure and function of influenza virus NS1 and NS2 proteins].
abstract: This review discusses the structure and function of the influenza virus NS1 and NS2 proteins. The NS1 is a phosphoprotein and has two nuclear localization signals. In the nucleus, the NS1 interferes with the splicing as well as the nuclear export of cellular mRNAs. In the later time of the infection, the NS1 is present in the cytoplasm and associates with the polysomes. The NS1 binds to the 5'UTR of some viral mRNAs and stimulates translation. The NS2 is a phosphoprotein and binds to the nucleoporin yRip1 and Rab/hRip as well as the M1 protein which associates with the vRNPs. Therefore, the NS2 protein plays an important role in the nuclear export of the vRNPs. Improved technique to genetically manipulate influenza virus allowed us to rescue NS1 and NS2 mutants which are useful for further study.
authors.affiliation: Department of Biochemistry, Kanazawa University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Enami
mesh_terms: D015967:Gene Expression Regulation, Viral; D009975:Orthomyxoviridae / Q000737:chemistry* / Q000502:physiology*; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000502:physiology*
chemical_list: C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins