Glucose transporter Glut 5 expression in microglial cells.
Glut 5 is a member of a family of facilitative glucose transporter proteins that are involved in the transportation of glucose and/or fructose across plasma membranes. Glut 5 is one of three isoforms expressed in brain. Using immunocytochemical and immunoblotting techniques in formalin fixed tissue, we have shown that Glut 5 is exclusively expressed in microglial cells of the human and rat brain. Our data demonstrate that unlike other microglial markers, Glut 5 can be used as a microglial marker in formalin fixed tissue.
Payne
J
J
Pathology Department, Albert Einstein College of Medicine, Bronx, New York 1046, USA.
Maher
F
F
Simpson
I
I
Mattice
L
L
Davies
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D002675:Child, Preschool; D005947:Glucose / Q000378:metabolism*; D051296:Glucose Transporter Type 5; D006801:Humans; D017628:Microglia / Q000166:cytology / Q000378:metabolism*; D008875:Middle Aged; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins / Q000096:biosynthesis*; D051381:Rats
D051296:Glucose Transporter Type 5; D009004:Monosaccharide Transport Proteins; D005947:Glucose