The HLA A1-B8 haplotype extends 6 Mb beyond HLA-A: associations between HLA-A, B, F and 15 microsatellite markers.
Allele frequencies for HLA-A, B and F and 15 microsatellite markers located from 100 kb telomeric to HLA-A to 6 Mb telomeric have been determined in a group of 60 blood donors. Linkage disequilibrium analysis revealed significant haplotype associations even after correction for the number of comparisons made. The HLA-A1, B8 haplotype extends as far as D6S276 (6.0 Mb telomeric to HLA-A). It is important to realize that this common haplotype extends beyond the HLA region, especially when evaluating haplotype associations with particular disorders.
Worwood
M
M
Department of Haematology, University of Wales College of Medicine, Cardiff, United Kingdom. Worwood@Cardiff.ac.uk
Raha Chowdhury
R
R
Robson
K J
KJ
Pointon
J
J
Shearman
J D
JD
Darke
C
C
D015415:Biomarkers; D004276:DNA, Satellite / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*
D015415:Biomarkers; D004276:DNA, Satellite; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; C062341:HLA-F antigens; D015395:Histocompatibility Antigens Class I