Effect of lidocaine administration on the enkephalin-degrading aminopeptidase activities in discrete areas of the rat brain.
1. The levels of three aminopeptidase activities involved in the degradation of enkephalins (soluble, M and MII) in several rat brain areas were studied after lidocaine administration. 2. Soluble aminopeptidase activity showed decreases in the frontal cortex and in the pituitary gland after treatment. 3. No significant changes in the complete membrane-bound aminopeptidase activity were appreciated in any other of the brain areas. 4. However, decreases of the membrane-bound puromycin-insensitive aminopeptidase activity in the frontal cortex, the hippocampus and the thalamus, after lidocaine administration, were observed.
de Gandarias
J M
JM
Department of Physiology, Medical School, University of the Basque Country, Bilbao, Spain.
Irazusta
J
J
Fernández
D
D
Varona
A
A
Gil
J
J
Casis
L
L
D000626:Aminopeptidases / Q000378:metabolism*; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D004745:Enkephalins / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D007700:Kinetics; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008566:Membranes / Q000187:drug effects / Q000201:enzymology; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013788:Thalamus / Q000187:drug effects / Q000201:enzymology
D000779:Anesthetics, Local; D004745:Enkephalins; D011691:Puromycin; D008012:Lidocaine; D000626:Aminopeptidases