title: Protein synthesis- and fucosylation-dependent mechanisms in corticosterone facilitation of long-term memory in the chick.
abstract: Long-term memory formation for a passive avoidance task in day-old chicks, which requires a late phase of glycoprotein fucosylation (5-8 hr posttraining), is dependent on a corticosterone action in the brain. In addition, corticosterone enhances late-phase fucosylation. In this study, the authors explored (a) to what extent the memory-facilitating action of corticosterone is dependent on protein fucosylation and (b) whether a protein synthesis mechanism might be involved in the steroid effects on memory and late-phase fucosylation. A combination of psychopharmacological and biochemical experiments, including the fucosylation inhibitor 2-deoxygalactose (2-DG), the protein synthesis inhibitor anisomycin (ANI), and radiolabeled fucose, indicated that the late phase of glycoprotein synthesis involved in the memory-facilitating effect of corticosterone occurs on newly synthesized proteins.
authors.affiliation: Behavior Research Group, Open University, Milton Keynes, United Kingdom. csandi@cu.uned.es
authors.forename: C
authors.initials: C
authors.lastname: Sandi
authors.forename: S P
authors.initials: SP
authors.lastname: Rose
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001931:Brain Mapping; D002645:Chickens / Q000502:physiology*; D003345:Corticosterone / Q000502:physiology*; D005643:Fucose / Q000378:metabolism* / Q000494:pharmacology; D007267:Injections; D008562:Membrane Glycoproteins; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D018992:Myelin-Associated Glycoprotein / Q000096:biosynthesis*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011499:Protein Processing, Post-Translational / Q000187:drug effects / Q000502:physiology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology*; D014158:Transcription, Genetic / Q000187:drug effects / Q000502:physiology
chemical_list: D008562:Membrane Glycoproteins; D018992:Myelin-Associated Glycoprotein; D009419:Nerve Tissue Proteins; D011500:Protein Synthesis Inhibitors; D005643:Fucose; D000841:Anisomycin; D003345:Corticosterone