title: Malignant lymphoma involving the penis following malignant pleural mesothelioma.
abstract: A 74-year-old man who had been diagnosed with malignant mesothelioma developed malignant lymphoma of B-cell origin involving the penis. He had a history of occupational exposure to asbestos as a construction worker. The association of malignant mesothelioma with lymphoma is rare, and the possibility of asbestos exposure as a common etiology is discussed. The intense stimulation of B lymphocytes and decreased T lymphocyte activity in asbestos-exposed populations may result in development of B-cell malignancies. Though the relationship between asbestos exposure and malignant mesothelioma is firmly established, the relationship between asbestos exposure and lymphoma remains to be investigated.
authors.affiliation: Department of Internal Medicine, Yokosuka Kyosai Hospital, Kanagawa.
authors.forename: K
authors.initials: K
authors.lastname: Takabe
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukada
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: J
authors.initials: J
authors.lastname: Takagiwa
authors.forename: M
authors.initials: M
authors.lastname: Hirayama
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: H
authors.initials: H
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Akabane
authors.forename: S
authors.initials: S
authors.lastname: Takayama
authors.forename: S
authors.initials: S
authors.lastname: Aida
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001194:Asbestos / Q000009:adverse effects; D001706:Biopsy; D002273:Carcinogens / Q000009:adverse effects; D017809:Fatal Outcome; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D016273:Occupational Exposure / Q000009:adverse effects; D010412:Penile Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D010997:Pleural Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D013902:Radiography, Thoracic
chemical_list: D000970:Antineoplastic Agents; D002273:Carcinogens; D001194:Asbestos