Cisplatinum and interstitial laser therapy for advanced head and neck cancer: a preclinical study.
OBJECTIVE
Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA).


METHODS
Human SCCA tumors were grown as s.c. transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300 J).


RESULTS
Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week follow-up. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone.


CONCLUSIONS
These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.
Paiva
M B
MB
Department of Surgery, UCLA School of Medicine 90095-1794, USA.
Saxton
R E
RE
VanderWerf
Q M
QM
Bell
T
T
Eshraghi
A A
AA
Graeber
I P
IP
Feyh
J
J
Castro
D J
DJ
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D053685:Laser Therapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation
D000970:Antineoplastic Agents; D002945:Cisplatin