Effect of muscular exercise on the concentration of uridine and purine bases in plasma--adenosine triphosphate consumption-induced pyrimidine degradation.
To identify whether muscular exercise increases the plasma concentration of uridine and of purine bases, the effect of rigorous muscular exercise was determined in five healthy men with a bicycle ergometer. Twenty-five-minute muscular exercise at 65% maximum O2 consumption increased the concentration of uridine, purine bases, and inorganicphosphate in plasma and of NH3 and lactic acid in blood. These results suggest that exercise-induced excessive adenosine triphosphate (ATP) consumption enhanced not only purine degradation but also pyrimidine degradation (uridine triphosphate [UTP]-->uridine diphosphate [UDP]-->uridine monophosphate [UMP]-->uridine) in exercising muscles.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Moriwaki
Y
Y
Takahashi
S
S
Tsutsumi
Z
Z
Yamakita
J
J
Higashino
K
K
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000641:Ammonia / Q000097:blood / Q000378:metabolism; D001784:Blood Gas Analysis; D015444:Exercise / Q000502:physiology*; D006801:Humans; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000097:blood / Q000378:metabolism; D011687:Purines / Q000097:blood* / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism*; D014529:Uridine / Q000097:blood* / Q000378:metabolism
D010710:Phosphates; D011687:Purines; D011743:Pyrimidines; D019344:Lactic Acid; D000641:Ammonia; D000255:Adenosine Triphosphate; D014529:Uridine