Expression of P-glycoprotein in inner ear capillary endothelial cells of the guinea pig with special reference to blood-inner ear barrier.
Expression of P-glycoprotein (P-gp) was detected immunohistochemically in the guinea pig inner ear using mouse anti-P-gp monoclonal antibody C219. P-gp was found only in the capillary endothelial cells of the cochlea and vestibule. The pattern of P-gp immunostaining in the inner ear was similar to that of the brain. The present investigation suggested that P-gp expression in inner ear capillary endothelial cells might play an important role in the blood-inner ear barrier by acting as an extrusion pump.
Saito
T
T
Department of Otolaryngology, Fukui Medical School, Japan.
Zhang
Z J
ZJ
Tsuzuki
H
H
Ohtsubo
T
T
Yamada
T
T
Yamamoto
T
T
Saito
H
H
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000818:Animals; D002199:Capillary Permeability; D007758:Ear, Inner / Q000098:blood supply*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006168:Guinea Pigs; D007150:Immunohistochemistry
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1