Early changes in circulating blood volume and volume regulating humoral factors after implantation of an electrohydraulic total artificial heart.
The early changes in circulating blood volume (CBV) and volume regulating humoral factors after implantation of an electrohydraulic total artificial heart (EH-TAH) were investigated in a calf and compared with results in a sham operated control calf. CBV was measured by the dye dilution method using indocyanine green. CBV and humoral factors were periodically investigated. In the EH-TAH implanted calf, the cardiac output was estimated at 6-7 L/ min (94-109 ml/kg/min), and the aortic pressure and aerobic metabolic condition were favorable. Nevertheless, the CBV was increased to 132 and 168% of the pre-operative value (range in the control calf, 83-103%) on post operative days 4 and 8, respectively. The atrial natriuretic peptide level on days 2, 5, and 7 was 23, 170, and 240 (in the control calf, 19-61) pg/ml, respectively, and the antidiuretic hormone level was 7.3, 2.0, and 1.3 (0.5-1.3) pg/ ml, respectively. The plasma renin activity was 3.2, 3.7, and 3.1 (0.5-0.3) ng/ml/hr, respectively. The angiotensin-I and angiotensin-II levels were also increased in the EH-TAH implanted calf. It is concluded that significant water retention occurs even at sufficient cardiac output early after EH-TAH implantation. The changes in humoral factors are suggested to arise secondary to the increased CBV or other unknown factors.
Nakamura
M
M
Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
Tatsumi
E
E
Masuzawa
T
T
Taenaka
Y
Y
Nakatani
T
T
Sohn
Y
Y
Endo
S
S
Ohno
T
T
Takiura
K
K
Nishimura
T
T
Takewa
Y
Y
Wakisaka
Y
Y
Takano
H
H
D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D001810:Blood Volume / Q000502:physiology*; D002302:Cardiac Output; D002417:Cattle; D006354:Heart, Artificial / Q000009:adverse effects*; D006439:Hemodynamics; D011474:Prosthesis Design; D012083:Renin / Q000097:blood; D014667:Vasopressins / Q000097:blood
D014667:Vasopressins; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D000803:Angiotensin I; D012083:Renin