Progress in antisense therapeutics discovery and development.
Progress in the discovery and development of antisense therapeutics continues at a rapid pace. Detailed understanding of the pharmacokinetic, toxicological and pharmacological properties of phosphorothioate oligonucleotides is now available. Further, an ever-increasing body of information is available about new and improved chemical classes of antisense drugs that are progressing toward clinical trials.
Crooke
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Isis Pharmaceuticals Inc., Carlsbad Research Center, CA 92008, USA.
D000818:Animals; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000627:therapeutic use*; D013873:Thionucleotides / Q000737:chemistry / Q000627:therapeutic use*
D016376:Oligonucleotides, Antisense; D013873:Thionucleotides