[Effect of microinjection of angiotensin II into area postrema on renal sodium excretion].
It has been known that area postrema (AP) possesses angiotensin II (A II) receptors and senses directly the change of blood A II level. The effect of microinjection of A II into the AP on renal sodium excretion was studied in the present investigation. Our experimental results show that microinjection of A II (2, 20 ng) increases GFR, RPF and UNaV (P < 0.05). These changes can be abolished by A II antagonist, saralatin and renal denervation (P < 0.05). However microinjection of A II (20 ng) into NTS produces no such changes. These results strongly suggest that the A II induced changes of renal hemodynamics and urine sodium excretion are mediated through AP.
Peng
A
A
Division of Nephrology, Huashan Hospital, Shanghai Medical University.
Lin
S Y
SY
Hao
C M
CM
Li
P
P
Zhou
J H
JH
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D005919:Glomerular Filtration Rate; D008297:Male; D008845:Microinjections; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017595:Renal Plasma Flow; D012964:Sodium / Q000652:urine*
D000804:Angiotensin II; D012964:Sodium