[Determination of content of chlorpromazine hydrochloride in compound metamizole sodium microenema by acid-dye colorimetric method].
An acid-dye colormetric method was described for the determination of chlorpromazine hydrochloride in the compound preparation. The method was based on the reaction of chlorpromazine hydrochloride with methyl orange, to form a yellow complex, which then was extracted by chloroform and exhibited a maximum absorption at 424 nm. The optimal conditions for determination were selected by orthogonal design test. The linear range of this method was 20-120 micrograms/ml (r = 0.9997). The average recovery of the three sample solutions of different concentrations was 99.72% +/- 0.46% (n = 6). The other ingredients of preparation do not interfere with chlorpromazine determination. This method is more sensitive and accurate and can be used for quality control of this compound preparation.
Zhou
Z
Z
Department of Pharmaceutical Analysis, School of Pharmacy, Chengdu.
Wang
L
L
Peng
Y
Y
Zhang
X
X
D002746:Chlorpromazine / Q000032:analysis*; D003124:Colorimetry / Q000379:methods; D004177:Dipyrone / Q000737:chemistry*; D004338:Drug Combinations; D004733:Enema
D004338:Drug Combinations; D004177:Dipyrone; D002746:Chlorpromazine