The leukocyte beta 1 integrins.
We summarize publications appearing in the past year on the blood cell beta 1 integrins VLA-1 through -6, including characterization of their ligand interactions, activation epitopes, signaling mechanisms, cellular distribution, and in vivo relevance. These studies extend our understanding of the beta 1 integrins, and continue to underscore their importance in leukocyte biology, which derives from their central role in mechanisms of cellular adhesion, growth, and differentiation.
Hemler
M E
ME
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Lobb
R R
RR
D000818:Animals; D000939:Epitopes; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D019012:Integrin beta1 / Q000097:blood*; D016023:Integrins / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism*; D015398:Signal Transduction; D013950:Thymus Gland / Q000502:physiology
D000939:Epitopes; D019012:Integrin beta1; D016023:Integrins