Improved oral bioavailability of the hypocholesterolemic DMP 565 in dogs following oral dosing in oil and glycol solutions.
Burcham
D L
DL
Drug metabolism and Pharmacokinetics Section, DuPont Merck Pharmaceutical Company, Newark, DE 19714, USA.
Maurin
M B
MB
Hausner
E A
EA
Huang
S M
SM
D000284:Administration, Oral; D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004285:Dogs; D006207:Half-Life; D007269:Injections, Intra-Arterial; D008297:Male; D011092:Polyethylene Glycols; D012450:Safflower Oil; D013261:Sterols / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*
D000924:Anticholesteremic Agents; C110089:DMP-565; D013261:Sterols; D011092:Polyethylene Glycols; D012450:Safflower Oil