[Effects of AEA-I on murine IL-2 and IL-6 activities in vivo].
Antitumor-I (AT-I) is known as an effective traditional Chinese medicine to be used in combination with chemotherapeutic agents against tumor. It was demonstrated that AT-I could inhibit tumor growth and modulate IL-2, IL-6 and NK cell activities. In order to improve its preparation, we got the alcohol extract from AT-I (AEA-I) by using natural pharmaceutical alcohol extract method, and compared the effect of AEA-I on cytokins with that of AT-I. The results show that AEA-I has a good positive correlation with AT-I on IL-2 and IL-6 activities of mice in vivo.
Lei
X
X
Department of Pharmacology, School of Basic Medical Sciences, Chengdu.
Chu
Y
Y
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D007376:Interleukin-2 / Q000276:immunology*; D015850:Interleukin-6 / Q000276:immunology*; D008297:Male; D008419:Materia Medica / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology
D000972:Antineoplastic Agents, Phytogenic; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D015850:Interleukin-6; D008419:Materia Medica