Is stimulation of class-1 phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.
In summary, it is still unclear which type of PI 3-kinase is involved in the activation of glycogen synthase. However, there is a strong body of evidence to suggest class-1 PI 3-kinase activity is necessary for insulin stimulation of glucose transport and a growing body of evidence to suggest that insulin stimulation of this class of PI 3-kinase is sufficient to stimulate glucose transport. However, the mechanism by which PI 3-kinase lipid products stimulate glucose transport is still not clear.
Shepherd
P R
PR
Department of Biochemistry, University College London, U.K.
Siddle
K
K
Navé
B T
BT
D000818:Animals; D001692:Biological Transport; D004789:Enzyme Activation; D005947:Glucose / Q000378:metabolism*; D006006:Glycogen Synthase / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology* / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000145:classification / Q000378:metabolism*
D007328:Insulin; D006006:Glycogen Synthase; D019869:Phosphatidylinositol 3-Kinases; D005947:Glucose