title: Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
abstract: Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel.
authors.affiliation: Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam.
authors.forename: J
authors.initials: J
authors.lastname: van Asperen
authors.forename: O
authors.initials: O
authors.lastname: van Tellingen
authors.forename: A
authors.initials: A
authors.lastname: Sparreboom
authors.forename: A H
authors.initials: AH
authors.lastname: Schinkel
authors.forename: P
authors.initials: P
authors.lastname: Borst
authors.forename: W J
authors.initials: WJ
authors.lastname: Nooijen
authors.forename: J H
authors.initials: JH
authors.lastname: Beijnen
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D003524:Cyclosporins / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D017239:Paclitaxel / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D003524:Cyclosporins; D004338:Drug Combinations; D017239:Paclitaxel; C070272:valspodar