title: [Biochemical parameters in the diagnosis of nephrotoxicity of antineoplastic chemotherapy in children].
abstract: The investigation was concerned with the role of enzymouria in the assessment of nephrotoxic effects identified in 19 children with malignant solid tumors who received cisplatin polychemotherapy in a dose of 100 mg/sq.m or iphosphamide in a dose 9 g/sq.m. Chemotherapy application was followed by a persistent hyperenzymouria involving significantly higher levels of N-acetyl-beta-D-hexosaminidase, beta-glutamyl transferase and alanine aminopeptidase in the urine, as compared with basal indices. Iphosphamide treatment showed significantly higher levels of enzymouria than those in cisplatin-treated patients. Higher than normal creatinine and urea concentrations were recorded only in 2 out of 9 patients receiving iphosphamide. Enzymouria evaluation was shown to be an effective method of nephrotoxic diagnosis.
authors.forename: N V
authors.initials: NV
authors.lastname: Liubimova
authors.forename: Zh Kh
authors.initials: ZhKh
authors.lastname: Kumykova
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskiĭ
authors.forename: Ch M
authors.initials: ChM
authors.lastname: Kasumov
authors.forename: L A
authors.initials: LA
authors.lastname: Durnov
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000009:adverse effects; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000652:urine*; D051437:Renal Insufficiency / Q000097:blood* / Q000139:chemically induced / Q000652:urine*; D014508:Urea / Q000097:blood / Q000652:urine
chemical_list: D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D014508:Urea; D003404:Creatinine; D002945:Cisplatin; D007069:Ifosfamide