[Studies on glutamate and GABA receptor expressed in amphibian oocytes after injection of carp retina mRNA].
Using voltage clamp and perfusion technique, the types and characteristics of amino acid receptors of carp (Carassius carassius) retinas were studied by expressed response of amphibian oocytes previous injected with the retinal mRNA. The results were as follows: (1) Glu receptor: Diazoxide could potentiated KA induced depolarization, suggesting that some of the retinal Glu receptors may be AMPA-preferring subtype. (2) GABA receptor: Bicuculine could greatly suppress the GABA induced inward rapid current, while GABAB agonist baclofen was without effect. This suggests that the most of retinal GABA receptors may be GABAA type.
Bao
Y D
YD
Laboratory of Retina Research, Shanghai Institute of Physiology, Chinese Academy of Sciences.
Zhu
H
H
Zhu
X
X
D000818:Animals; D002347:Carps; D009865:Oocytes / Q000378:metabolism*; D018408:Patch-Clamp Techniques; D012333:RNA, Messenger / Q000494:pharmacology*; D018079:Receptors, GABA / Q000096:biosynthesis*; D017470:Receptors, Glutamate / Q000096:biosynthesis* / Q000145:classification; D012160:Retina / Q000378:metabolism*; D014982:Xenopus laevis
D012333:RNA, Messenger; D018079:Receptors, GABA; D017470:Receptors, Glutamate