[A study of the effects of chemotherapy with or without G-CSF on neutrophil counts and serum G-CSF levels in leukemia patients].
For studying the relation between the serum G-CSF levels and neutrophil counts, consecutive changes of G-CSF levels and neutrophil counts in 20 cases of acute leukemia receiving chemotherapy with or without administration of G-CSF were observed. The G-CSF levels were detected by ELISA. The results showed: (1) Before chemotherapy G-CSF levels were higher than normal value in acute leukemia patients. (2) Four patterns of consecutive change of serum G-CSF levels in 19 cases receiving chemotherapy alone were observed, viz curves with double peaks, single peak, V type and declining type. Different patterns of G-CSF change were accompanied with different changes of neutrophil counts. (3) Both serum G-CSF levels and neutrophil counts were elevated significantly in nine cases receiving G-CSF after chemotherapy. (4) Comparing chemotherapy with and without G-CSF treatment. The time required for neutrophil count to reach a level more than 1.5 x 10(9)/L was significantly shorter in those administering G-CSF after chemotherapy than the patients not using G-CSF. These results suggest that observation of the changes of serum G-CSF levels is helpful in judging myelosuppression and marrow recovery after chemotherapy. Administration of G-CSF is an effective method to increase the neutrophil counts and to shorten the myelosuppressive period.
Chen
S
S
Peking Union Medical Hospital, Beijing.
Zhang
Z
Z
Liu
P
P
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood* / Q000627:therapeutic use*; D006801:Humans; D007951:Leukemia, Myeloid / Q000276:immunology / Q000628:therapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology / Q000628:therapy*; D011817:Rabbits; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor