Recovery of PdiTwitch following the induction of diaphragm fatigue in normal subjects.
Low frequency diaphragm fatigue (LFF) may play a major role in the pathogenesis of ventilatory failure; however, recovery from LFF is not well studied. We measured transdiaphragmatic twitch pressure (PdiT) at FRC (using a reduction of PdiT as an index of LFF) and maximum transdiaphragmatic pressure (Pdimax) before and after the induction of diaphragm fatigue in seven normal subjects, age 31 +/- 3 yr (mean +/- SD). Fatigue was induced by breathing through an inspiratory resistive load. PdiT produced by bilateral transcutaneous supramaximal electrophrenic stimulation was measured at baseline, 15, 30 min, 1, 2, 3, 4 h, and then 1 to 3 times between hour 20-25 post-fatigue. Pdimax estimated by twitch occlusion was measured at baseline, 30 min, 2-3, and 20-25 h post-fatigue. Pre-fatigue values (mean +/- SE) were: PdiT 23.6 +/- 2.5 cm H2O. The mean +/- SD time to fatigue was 25.3 +/- 12.3 min. Post-fatigue PdiT was reduced to 50%, and by 3 h was 72% of the initial value; 100% by 25 h. Pdimax was reduced to 75% post-fatigue, but recovered to 87% by 3 h, and 100% by 25 h. We concluded that recovery of PdiT and Pdimax in normal subjects starts to occur within the first few hours following diaphragm fatigue, and is complete by 25 h.
Travaline
J M
JM
Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA. trav@astro.ocis.temple.edu
Sudarshan
S
S
Criner
G J
GJ
D000200:Action Potentials; D000328:Adult; D003964:Diaphragm / Q000502:physiology* / Q000503:physiopathology; D004558:Electric Stimulation; D004576:Electromyography; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D018763:Muscle Fatigue / Q000502:physiology*; D009126:Muscle Relaxation; D011312:Pressure; D012131:Respiratory Insufficiency / Q000503:physiopathology; D013997:Time Factors