title: Combined heart and kidney transplantation: an effective therapeutic option--report of six cases.
abstract: Six cases of combined heart and kidney transplantation with organs from the same donor are reported. All six patients suffered from primary end-stage kidney disease, two chronic glomerulonephritis, two glomerulosclerosis, one chronic pyelonephritis and one with unknown etiology. Four patients were undergoing hemodialysis. Three patients had the diagnosis of ischemic heart disease, one dilated cardiomyopathy secondary to congenital heart disease, two idiopathic dilated cardiomyopathy. Five were males and one female. Ages ranged from 38 to 54 years. On-site or short-distance young donors with normal renal function and good cardiac function necessitating low inotropic support were selected. ABO compatibility was used exclusively. Orthotopic heart transplantation was performed first. During cardiopulmonary bypass, hemofiltration was used in four cases. Kidney transplantation was performed immediately after the closure of the chest. Diuresis was immediate in all cases. No cardiac rejection was documented at EMB. Renal function normalized within few days with no signs of kidney rejection. All six patients are alive and well with normal cardiac and renal function at a mean follow-up of 43 months. Patients and donors selection associated with a proper surgical strategy and prompt immunosuppressive therapy administration make the combined heart and kidney transplantation an effective therapeutic option.
authors.affiliation: Cardiac Surgery Division, Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Colucci
authors.forename: E
authors.initials: E
authors.lastname: Quaini
authors.forename: P
authors.initials: P
authors.lastname: Magnani
authors.forename: T
authors.initials: T
authors.lastname: Colombo
authors.forename: L
authors.initials: L
authors.lastname: De Carlis
authors.forename: M
authors.initials: M
authors.lastname: Grassi
authors.forename: M
authors.initials: M
authors.lastname: Merli
authors.forename: A
authors.initials: A
authors.lastname: Pellegrini
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000601:surgery*; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000601:surgery*; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D000017:ABO Blood-Group System; D007166:Immunosuppressive Agents