Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities.
A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.
Romero
F
F
Drug Discovery Division, PharmaMar, S.A., Spain.
Espliego
F
F
Pérez Baz
J
J
García de Quesada
T
T
Grávalos
D
D
de la Calle
F
F
Fernández-Puentes
J L
JL
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D047630:Depsipeptides; D005285:Fermentation; D007941:Leukemia P388 / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D008847:Micromonospora; D010455:Peptides; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; D010455:Peptides; C109005:thiocoraline