[Antigenic epitopes of influenza virus specific CTL].
CTLs play an essential role in the protection to influenza virus infection. Virus specific CTLs recognize the complex of class I molecule and epitope peptide derived from viral proteins on surfaces of virus infected cells. In these 10 years great progress has been made in understanding of the process of epitope peptide production and the structure of the peptide. It has been clearly shown that proteasome and TAP are involved in the class I restricted antigen processing and epitope peptides have motifs depending on class I allele. In this article topics concerning CTL epitopes of influenza viruses are described; especially prediction and identification of epitopes are mainly discussed.
Kuroda
K
K
Department of Virology and Immunology, Osaka University of Pharmaceutical Sciences.
Hosaka
Y
Y
D000939:Epitopes / Q000276:immunology*; D009975:Orthomyxoviridae / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000939:Epitopes