[Effect of microinjection of neurotensin into hypothalamic paraventricular nucleus on gastric acid secretion in rats].
Effects of microinjection of neurotensin (NT) into the hypothalamic paraventricular nucleus (PVN) on gastric acid secretion were investigated in urethane-anesthetized rats. The results were as follows: NT microinjection into PVN produced a dose-dependent decrease in gastric acid output (GAO); this inhibitory effect of NT was completely blocked by icv pretreatment with the alpha-adrenergic receptor antagonist phentolamine or after bilateral cervical vagotomy, suggesting that the effect may be related with activation of alpha-adrenergic receptors in the nucleus and mediated by vagal nerves.
Han
X H
XH
Department of Physiology, Qingdao Medical College.
Chen
J J
JJ
Chen
L
L
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D008845:Microinjections; D009496:Neurotensin / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014628:Vagotomy
D000317:Adrenergic alpha-Antagonists; D009496:Neurotensin; D010646:Phentolamine