title: Development of a testicular haemangioma after interferon therapy for hepatic haemangiomas: a case report.
abstract: We report a 2-month-old Japanese boy presenting with large multiple haemangiomas invading his liver. He was treated with daily subcutaneous injection of interferon alfa (IFN-alpha)-2a with progressive reduction of the hepatic haemangioma. He developed a scrotal mass 2 months after discontinuation of IFN, and this mass eventually required surgical management. Resected tumour was a juvenile haemangioma. The escape of this haemangioma from IFN therapy may be correlated to the quite low level of injected IFN in testis.
  
  
  CONCLUSIONS
  IFN therapy may not be curative for testicular haemangioma although it is effective in shrinking haemangiomas of the liver and skin.
authors.affiliation: Department of Paediatrics, Sapporo Medical University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yanai
authors.forename: H
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: T
authors.initials: T
authors.lastname: Hotsubo
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Miyao
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Chiba
mesh_terms: D006391:Hemangioma / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D009919:Orchiectomy; D011859:Radiography; D011994:Recombinant Proteins; D013736:Testicular Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D013737:Testis / Q000473:pathology
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins