title: Effect of atrazine administration on spontaneous and evoked cerebellar activity in the rat.
abstract: The effect of atrazine oral administration on cerebellar forelimb projection area was studied in rats in vivo. Rats acutely treated with atrazine (100 mg kg-1, BW) showed a significant decrease in spontaneous Purkinje cell firing rate. Atrazine also decreased the cerebellar potentials evoked by electrical stimulation of the ipsilateral radial nerve, affecting mostly the response to climbing fiber input. These results demonstrate that atrazine exerts a toxic action on central nervous system. The effects on the cerebellar somatosensory cortex could be responsible for motor disorders frequently observed in animals intoxicated with atrazine.
authors.affiliation: Department of Biomedical Science, Section of Human Physiology, University of Sassari, Italy.
authors.forename: M V
authors.initials: MV
authors.lastname: Podda
authors.forename: F
authors.initials: F
authors.lastname: Deriu
authors.forename: A
authors.initials: A
authors.lastname: Solinas
authors.forename: M P
authors.initials: MP
authors.lastname: Demontis
authors.forename: M V
authors.initials: MV
authors.lastname: Varoni
authors.forename: A
authors.initials: A
authors.lastname: Spissu
authors.forename: V
authors.initials: V
authors.lastname: Anania
authors.forename: E
authors.initials: E
authors.lastname: Tolu
mesh_terms: D000818:Animals; D001280:Atrazine / Q000494:pharmacology*; D002531:Cerebellum / Q000187:drug effects* / Q000502:physiology; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects*; D006540:Herbicides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006540:Herbicides; D001280:Atrazine