The effect of chronic stress on hepatic and gastric lipid peroxidation in long-term depletion of glutathione in rats.
The effect of chronic stress (immobilization and cold) on hepatic and gastric thiobarbituric acid reactive substances (TBARS) and vitamin C levels were investigated in rats having long-term depletion of glutathione (GSH) by applying buthionine sulfoximine (BSO). GSH and vitamin C levels decreased and TBARS levels increased in the liver and stomach of rats subjected to stress. Long-term BSO administration along with stress caused no additional changes in these parameters. These results may indicate that long-term glutathione depletion did not potentiate stress-induced hepatic and gastric lipid peroxidation.
Seçkin
S
S
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
Alptekin
N
N
Doğru-Abbasoğlu
S
S
Koçak-Toker
N
N
Toker
G
G
Uysal
M
M
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D019328:Buthionine Sulfoximine / Q000494:pharmacology; D002908:Chronic Disease; D003080:Cold Temperature; D005753:Gastric Mucosa / Q000378:metabolism*; D005978:Glutathione / Q000172:deficiency* / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
D000963:Antimetabolites; D017392:Thiobarbituric Acid Reactive Substances; D019328:Buthionine Sulfoximine; D005978:Glutathione