[State of the art: treatment of malignant pleural and pericardial effusions].
Symptomatic malignant pleural effusions should be treated systemic chemotherapy in chemo-sensitive tumors such as small cell lung cancer, breast cancer, lymphoma, or ovarian cancer. In other non-chemo-sensitive malignancies including non-small cell lung cancer, water-sealed tube drainage and pleurodesis is the standard treatment of choice in most of the cases. Drugs for instillation should be blomycin or OK-432 if commercially available. Instead of the former standard drug tetracycline, doxycycline has been frequently used. As we have no randomized trials, this drug awaits phase III trials. Talc slurry has been accepted and counted as one of the standard choices in the western countries, however, it usually needs general anesthesia and adverse effects are not negligible. As we have little experience on this modality, it should not be considered as a standard treatment. Other antitumor drugs instillation, thoraco-abdominal shunting, and pleuro-pneumonectomy should be considered experimental because of the lack of randomized trials. Symptomatic pericardial malignant effusion or cardiac tamponade is an oncologic emergency. We had better to treat the patient immediately by pericardiocentesis under the cardiac echographic guidance. It should be reserved to solve in randomized trials that the best method would be pericardiocentesis alone, percutaneous continuous drainage, pericardial fenestration, or pericardio-thoraco fenestration. Instillation of drug like doxycycline, OK-432, or bleomycin, lacks phase III comparison and it should be categorized as experimental.
Saka
H
H
First Dept. of Internal Medicine, Nagoya University School of Medicine.
Shimokata
K
K
D000970:Antineoplastic Agents / Q000008:administration & dosage; D001761:Bleomycin / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000150:complications; D018288:Carcinoma, Small Cell / Q000150:complications; D004322:Drainage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications; D010490:Pericardial Effusion / Q000188:drug therapy / Q000628:therapy*; D010844:Picibanil / Q000008:administration & dosage; D016066:Pleural Effusion, Malignant / Q000188:drug therapy / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic
D000970:Antineoplastic Agents; D001761:Bleomycin; D010844:Picibanil