[Expression of p53 gene in oral squamous cell carcinoma and its relations with clinical and pathological parameters and prognosis of patients].
One hundred and eleven cases of oral squamous cell carcinoma (OSCC) were examined for overexpression of p53 protein by using immunohistochemical technique. Association of p53 protein overexpression with clinical and pathological parameters as well as prognosis of patients were also analyzed, p53 protein overexpression was commonly observed (69.4%) in the OSCC patients and might be used as a marker of carcinogenesis of OSCC. The level of p53 protein overexpression was correlated with the decreased three and/or five-year survival rate of OSCC. The presence of p53 was not correlated with patient's sex and age, site and size of tumor, degree of differentiation, node status or clinical stage of OSCC. Single factor COX proportional hazards regression model analysis indicated that there was no significant relationship between p53 overexpression and prognosis of OSCC. Multivariable COX model analysis failed to establish effective life function or risk rate function. This showed that all the parameters analyzed in this study as well as p53 overexpression were not significant or effective risk factors to predict prognosis of OSCC patients.
Mao
C
C
PUMC Hospital, CAMS, Beijing.
Lu
Y
Y
Lai
Q
Q
Xia
Y
Y
Yang
C
C
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D016158:Genes, p53; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D016159:Tumor Suppressor Protein p53