Organochlorine pesticide exposure and thyroid function: a study in human subjects.
We examined the serum levels of thyroxine and thyroid stimulating hormone in 103 rural subjects with respect to blood levels of organochlorine pesticide and occupation. We found that 24.3% of study subjects had depleted thyroxine levels in association with significantly lower organochlorine pesticide residues in blood. Sex, nutritional status, thyromegaly, or handling of pesticides in the course of work were not found to be factors contributing to depleted thyroxine levels.
Srivastava
A K
AK
Epidemiology Division, Industrial Toxicology Research Centre, Lucknow, India.
Gupta
B N
BN
Bihari
V
V
Mathur
N
N
Pangtey
B S
BS
Bharti
R S
RS
Godbole
M M
MM
D000328:Adult; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007194:India; D007306:Insecticides / Q000009:adverse effects* / Q000097:blood; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D012423:Rural Health; D013959:Thyroid Diseases / Q000097:blood / Q000139:chemically induced*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D013972:Thyrotropin; D013974:Thyroxine