Spontaneous regression of granulomatous mycosis fungoides in an HIV positive patient.
The development of mycosis fungoides in HIV-positive patients is uncommon. We describe the granulomatous type of mycosis fungoides in an HIV-positive patient whose cutaneous lesions regressed without treatment. In addition to HIV seropositivity and mycosis fungoides, he had a long history of pulmonary sarcoidosis. Immunophenotyping of the cutaneous lymphoid infiltrates revealed a predominance of CD4+ T cells, and monoclonality was demonstrated by T-cell gene rearrangement studies. The regression of mycosis fungoides in this patient was associated with a falling peripheral blood CD4 T-cell count.
Sorrells
T
T
Department of Pathology, Naval Medical Center, Portsmouth, Virginia, USA.
Pratt
L
L
Newton
J
J
Graham
S
S
Ryan
M
M
D000328:Adult; D001706:Biopsy; D018791:CD4 Lymphocyte Count; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008297:Male; D009182:Mycosis Fungoides / Q000276:immunology* / Q000473:pathology; D012075:Remission, Spontaneous; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology