[Determination of the proliferative activity of the cervix uteri epithelium in papillomavirus infection].
The results of examinations of 35 patients aged 17 to 42 years who had abnormalities in the cervix uteri were analyzed. Colposcopy detected an atypical epithelium in 100% of cases. To verify the diagnosis, biopsy specimens from the cervix uteri were morphologically studied prior to and following treatment. Before treatment, there was a slight proliferative activity of the epithelium in 45% of cases and its high proliferative activity in 15% in uncomplicated papilloma viral infection (PVI). A follow-up of complicated PVI indicated increases in the expression of a proliferative nuclear antigen (PVA) with higher dysplasia: a moderate response in 75% of D3 + PVI cases and a higher response in 60% of preinvasive cancers. Analysis of PCNA-immunological reactivity of biopsy specimens taken after treatment estimates the efficiency of the chosen complex of treatments: there was a negative result of immunohistochemical responses.
Manukhin
I B
IB
Frank
G A
GA
Minkina
G N
GN
Simonova
T V
TV
Kulagina
L A
LA
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002455:Cell Division; D002584:Cervix Uteri / Q000473:pathology*; D003127:Colposcopy; D003218:Condylomata Acuminata / Q000175:diagnosis* / Q000628:therapy; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011230:Precancerous Conditions / Q000175:diagnosis; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002577:Uterine Cervical Diseases / Q000175:diagnosis* / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis