[Liver metastases from breast cancer 14 years after radical mastectomy; successful treatment with hepatic arterial infusion chemotherapy and systemic endocrine therapy--a case report].
The patient was a 73-year-old woman who was admitted to our hospital for epigastric discomfort and body weight loss. She had undergone radical right mastectomy in March 1982. Ultrasonography and computed tomography revealed multiple tumors in the liver. Three of the tumor markers (CA-125, CA 19-9, and CA 15-3) were positive. US-guided fine needle aspiration biopsy of the liver tumor showed small atypical cells with solid cell nests. Immunohistochemical tests revealed estrogen receptor was positive. We diagnosed the patient as recurrent breast cancer metastatic to liver, 14 years postoperatively. The liver tumors were successfully controlled with the combination of intra-arterial infusion chemotherapy (5-fluorouracil, epirubicin, and mitomycin C) along with systemic endocrine therapy (medroxyprogesterone acetate and fadrozole hydrochloride hydrate).
Onogawa
S
S
Dept. of Hepato-Gastroenterology, Shizuoka General Hospital.
Ito
K
K
Nishimura
K
K
Umeda
Y
Y
Kojima
K
K
Imai
R
R
Nakajima
N
N
Nakagami
K
K
Tohyama
K
K
Suzuki
M
M
Arai
K
K
Muro
H
H
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D015251:Epirubicin / Q000008:administration & dosage; D017316:Fadrozole / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008207:Lymphatic Metastasis; D015409:Mastectomy, Radical; D008525:Medroxyprogesterone / Q000008:administration & dosage; D016685:Mitomycin / Q000008:administration & dosage; D013997:Time Factors
D015251:Epirubicin; D016685:Mitomycin; D017316:Fadrozole; D008525:Medroxyprogesterone; D005472:Fluorouracil