title: Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice.
abstract: Ampullosporin (I; Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol) was isolated from the mycelium of Sepedonium ampullosporum as a new 15-membered peptaibol-type antibiotic. The structure was determined by mass spectrometric and two-dimensional NMR experiments. Ampullosporin displays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructiva, causes hypothermia and decreased spontaneous locomotor activity in mice in dosages > 1 mg/kg.
authors.affiliation: Hans-Knöll-Institute of Natural Products Research, Jena, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Ritzau
authors.forename: S
authors.initials: S
authors.lastname: Heinze
authors.forename: K
authors.initials: K
authors.lastname: Dornberger
authors.forename: A
authors.initials: A
authors.lastname: Berg
authors.forename: W
authors.initials: W
authors.lastname: Fleck
authors.forename: B
authors.initials: B
authors.lastname: Schlegel
authors.forename: A
authors.initials: A
authors.lastname: Härtl
authors.forename: U
authors.initials: U
authors.lastname: Gräfe
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi; D015394:Molecular Structure; D054848:Peptaibols; D010455:Peptides
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054848:Peptaibols; D010455:Peptides; C109004:ampullosporin