title: Acid-sensing by carotid body is inhibited by blockers of voltage-sensitive Ca2+ channels.
abstract: The membrane potential hypothesis that the responses to hypercapnia of carotid chemosensory activity is mediated by voltage-gated Ca2+ channels was investigated by measuring directly the chemosensory output from rat and cat carotid bodies, perfused and superfused in vitro. We found that the inorganic and organic blockers of voltage-gated Ca2+ channels suppressed the hypercapnic responses, thereby supporting the membrane potential hypothesis.
authors.affiliation: University of Pennsylvania, School of Medicine, Department of Physiology, Philadelphia 19104-6085, USA.
authors.forename: A
authors.initials: A
authors.lastname: Roy
authors.forename: C
authors.initials: C
authors.lastname: Rozanov
authors.forename: R
authors.initials: R
authors.lastname: Iturriaga
authors.forename: A
authors.initials: A
authors.lastname: Mokashi
authors.forename: S
authors.initials: S
authors.lastname: Lahiri
mesh_terms: D000143:Acids / Q000378:metabolism*; D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000502:physiology*; D002344:Carotid Body / Q000187:drug effects* / Q000502:physiology*; D002415:Cats; D002628:Chemoreceptor Cells / Q000187:drug effects* / Q000473:pathology*; D004594:Electrophysiology; D005260:Female; D006935:Hypercapnia / Q000503:physiopathology; D015640:Ion Channel Gating / Q000502:physiology; D008297:Male; D008564:Membrane Potentials; D009543:Nifedipine / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000143:Acids; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D002104:Cadmium; D014700:Verapamil; D009543:Nifedipine