title: Insulinotropic action of 1,2,3-Tri(methylsuccinyl)glycerol ester.
abstract: A novel ester of succinic acid, 1,2,3-tri(methylsuccinyl)glycerol ester (3SMG), was found to stimulate insulin release from rat pancreatic islets. In the presence of 7 mM d-glucose, a 10 microM concentration of 3SMG was sufficient to cause a significant increase in insulin output. The ester mimicked the effect of other nutrient secretagogues in enhancing the synthesis of islet peptides, with a preferential action on proinsulin as distinct from nonhormonal peptides, in decreasing 86Rb outflow from prelabeled islets, and in stimulating Ca2+ inflow into the islet cells. It is proposed, therefore, that 3SMG displays the attributes suitable for stimulation or potentiation of insulin release in noninsulin-dependent diabetes, without requiring administration in large amounts and, hence, without the risk of excessive hepatic gluconeogenesis.
authors.affiliation: Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium.
authors.forename: W J
authors.initials: WJ
authors.lastname: Malaisse
authors.forename: L
authors.initials: L
authors.lastname: Ladrière
authors.forename: A
authors.initials: A
authors.lastname: Laghmich
authors.forename: K
authors.initials: K
authors.lastname: Louchami
authors.forename: H
authors.initials: H
authors.lastname: Jijakli
authors.forename: C
authors.initials: C
authors.lastname: Viñambres
authors.forename: M L
authors.initials: ML
authors.lastname: Villanueva-Peñacarrillo
authors.forename: I
authors.initials: I
authors.lastname: Valverde
authors.forename: F
authors.initials: F
authors.lastname: Björkling
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004952:Esters / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010649:Phenylalanine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012414:Rubidium Radioisotopes / Q000378:metabolism; D013386:Succinates / Q000494:pharmacology*
chemical_list: C109543:1,2,3-tri(methylsuccinyl)glycerol ester; D004952:Esters; D007328:Insulin; D012414:Rubidium Radioisotopes; D013386:Succinates; D010649:Phenylalanine; D002118:Calcium