Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: the profound effect of polarity on antiviral activity.
Hagen
S E
SE
Department of Chemistry, Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105, USA.
Prasad
J V
JV
Boyer
F E
FE
Domagala
J M
JM
Ellsworth
E L
EL
Gajda
C
C
Hamilton
H W
HW
Markoski
L J
LJ
Steinbaugh
B A
BA
Tait
B D
BD
Lunney
E A
EA
Tummino
P J
PJ
Ferguson
D
D
Hupe
D
D
Nouhan
C
C
Gracheck
S J
SJ
Saunders
J M
JM
VanderRoest
S
S
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D051379:Mice; D011753:Pyrones / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D011753:Pyrones