title: Fever attributed to the use of hydroxyurea.
abstract: We report on three patients who developed fever after starting treatment with the anti-neoplastic agent, hydroxyurea. Fever occurred within 5 days to 3 weeks after starting treatment. In all cases the causal relationship between fever and use of hydroxyurea was demonstrated by spontaneous recovery after drug withdrawal and was confirmed by recurrence of fever after rechallenge. Other causes were excluded. Fever was accompanied by rash, gastro-intestinal and pulmonary symptoms, and arthralgia. Physicians should be aware of the fact that unexplained fever may be caused by hydroxyurea.
authors.affiliation: Drug Safety Unit, Inspectorate for Health Care, Rijswijk, Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: in 't Veld
authors.forename: A M
authors.initials: AM
authors.lastname: Slappendel
authors.forename: J
authors.initials: J
authors.lastname: Feenstra
authors.forename: C
authors.initials: C
authors.lastname: Veen
authors.forename: J
authors.initials: J
authors.lastname: van Aken
authors.forename: E A
authors.initials: EA
authors.lastname: Runhaar
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D012008:Recurrence; D013922:Thrombocytosis / Q000097:blood / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea