Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp.
A related group of compounds belonging to the antimycin class of antibiotics was found in culture broth produced by a Streptomyces species. The group includes known antimycins A1, A2, A3 and A4, and new antimycins A7 and A8. These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 microM against the substrate magnesium citrate. The structures of the new antimycins were determined by spectroscopic analyses.
Barrow
C J
CJ
Sterling Winthrop Pharmaceuticals Research Division, Malvern, PA 19355, USA.
Oleynek
J J
JJ
Marinelli
V
V
Sun
H H
HH
Kaplita
P
P
Sedlock
D M
DM
Gillum
A M
AM
Chadwick
C C
CC
Cooper
R
R
D001275:ATP Citrate (pro-S)-Lyase / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000968:Antimycin A / Q000031:analogs & derivatives*; D005285:Fermentation; D015394:Molecular Structure; D013302:Streptomyces; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000968:Antimycin A; D001275:ATP Citrate (pro-S)-Lyase