Oxygen radicals and renal diseases.
Reactive oxygen metabolites (superoxide, hydrogen peroxide, hydroxyl radical, and hypochlorous acid) are important mediators of renal damage in acute renal failure and glomerular and tubulointerstitial diseases. The role of these oxygen metabolites in the above entities is discussed, and the effects of antioxidants and scavengers of O2 radicals are considered. The role of oxygen radicals in the regulation of gene transcription is also considered.
Klahr
S
S
Department of Internal Medicine, Washington University School of Medicine, Barnes-Jewish Hospital, St. Louis, Mo. 63110, USA. sklahr@imgate.wustl.edu
D000818:Animals; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005609:Free Radicals; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000503:physiopathology; D011507:Proteinuria / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014158:Transcription, Genetic
D016166:Free Radical Scavengers; D005609:Free Radicals; D017382:Reactive Oxygen Species