[Experimental morphological study of posttraumatic proliferative vitreoretinopathy prevention by cell adhesion peptide Arg-Gly-Asp-Ser].
Proliferative vitreoretinopathy (PVR) was induced in 25 rabbits by injection of autologous adenosine phosphate-activated platelets in the vitreous. Injury to the internal interface retinal membrane as a result of adhesion of aggregated platelets to it, followed by the formation of an epiretinal membrane, underlies the morphogenesis of experimental PVR. Proliferative processes in the retina were paralleled by destructive atrophic changes in it, which might be due to active physiological substances released in the course of aggregation. The development of PVR was inhibited by a synthetic peptide of cell adhesion with Arg-Gly-Asp-Ser amino acid sequence, which was injected simultaneously with autologous activated platelets. Possible receptor mechanisms underlying the phenomenon of inhibition of the proliferative process in the retina of experimental animals are discussed.
Khoroshilova-Maslova
I P
IP
NII of Eyes Diseases, Moscow.
Babizhaev
M A
MA
Kiseleva
O A
OA
Ilatovskaia
L V
LV
D000818:Animals; D004195:Disease Models, Animal; D019773:Epiretinal Membrane / Q000473:pathology / Q000517:prevention & control; D005131:Eye Injuries / Q000150:complications*; D009842:Oligopeptides / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D018630:Vitreoretinopathy, Proliferative / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D014822:Vitreous Body / Q000473:pathology
D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; C046617:arginyl-glycyl-aspartyl-serine