title: Tyrosine kinases: modular signaling enzymes with tunable specificities.
abstract: Cytoplasmic tyrosine kinases are composed of modular domains; one (SH1) has catalytic activity, the other two (SH2 and SH3) do not. Kinase specificity is largely determined by the binding preferences of the SH2 domain. Attaching the SH1 domain to a new SH2 domain, via protein-protein association or mutation, can thus dramatically change kinase function.
authors.affiliation: Department of Chemistry, Princeton University, NJ 08544, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Shokat
mesh_terms: D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D013379:Substrate Specificity; D018909:src Homology Domains / Q000235:genetics / Q000502:physiology
chemical_list: D011505:Protein-Tyrosine Kinases