[The therapeutic efficacy and the effect of gidazepam and fenazepam on the psychophysiological status and on the performance of operators with mental disorders at a neurotic level].
The effect of placebo and gidazepam on the state, psychophysiological predictors of the quality of the operator's performance and its results in individuals with neurotic reactions was studied (test dose 20 mg 7-day course, 40 mg daily, 24 individuals), as well as the effect of gidazepam and phenazepam (42 individuals with neurotic and neurosis-like states; gidazepam test doses 20 and 50 mg, 14-day course, 40 and 100 mg daily; phenazepam test doses 0.5 and 1 mg, 14-day course, daily dose 2 mg). The generally accepted methods of clinical and psychophysiological examination were applied. Gidazepam in the doses under study did not yield to phenazepam in therapeutic activity. A single and a course administration of gidazepam improved the parameters of the psychophysiological state and the efficacy of the operator performance in patients with neurotic reactions and in those with neurotic and neurosis-like states. This makes it possible, whenever necessary, to recommend this drug for the treatment of the indicated disorders in the working operators.
Neznamov
G G
GG
Morozov
I S
IS
Barchukov
V G
VG
Teleshova
E S
ES
Siuniakov
S A
SA
Zhirov
E N
EN
Tkachev
A E
AE
Belyĭ
Iu N
IuN
Kolotilinskaia
N V
NV
Safarova
T P
TP
Barannikov
A S
AS
Chernyĭ
A V
AV
Shestopalov
S S
SS
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008889:Military Personnel / Q000523:psychology*; D009497:Neurotic Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D011597:Psychomotor Performance / Q000187:drug effects*; D011599:Psychopathology; D011603:Psychophysiology; D012426:Russia; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; C077010:gidazepam