[Relationship between c-erbB2 oncoprotein expression and biologic behavior of cervical squamous cell cancer].
OBJECTIVE
To investigate the relationship between c-erbB2 oncoprotein expression and biologic behavior and prognosis of cervical squamous cell cancer.


METHODS
Immunohistochemistry was used to examine the c-erbB2 oncoprotein expression in 62 cases of cervical sequamous cell cancer, 9 cases of cervical iutraepithelical neoplasia (CIN) and 10 cases of normal epidermal tissues section of the cervix.


RESULTS
Nineteen of 62 cancers and 1 of 9 cases of CIN showed positive staining. None of normal epithelium showed positive. In cervical cancer the positive staining rate of c-erbB2 oncoprotein in grade 1, 2 and 3 was 12.5%, 27.6% and 52.9% respectively. There was a significant difference between grade 1 + 2 and grade 3 (P = 0.019). In 20 cases operated on, 3 of 6 cases with positive staining had pelvic lymph node metastasis, while only 1 of 14 cases with negative staining had metastasis (P = 0.032). The 5-year survival rate of positive staining group was significantly lower than that of negative group (31.5% Vs 74.4%, P < 0.001).


CONCLUSIONS
The c-erbB2 oncoprotein expression on cervical sequamous cell cancer was related to agressive biologic behavior and poor prognosis.
Huang
Y
Y
Cancer Hospital, Shanghai Medical University.
Yu
S
S
Shi
D
D
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D018734:Genes, erbB-2; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D002578:Uterine Cervical Dysplasia / Q000235:genetics*
D018719:Erb-b2 Receptor Tyrosine Kinases