Effects of angiotensin II on biogenic monoamine uptake in the brain of nonhypoxic and hypoxic mice.
The effects of angiotensin II (ATII) administered intacerebroventricularly (i.c.v.) at a dose of 0.5 microgram per mouse on dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT) high-affinity uptake in mouse forebrain during hypoxia (asphyxic and hemic) were studied. The influence of hypoxia on biogenic monoamine uptake was also investigated. It was found that DA uptake increased, NA uptake decreased and 5-HT uptake was unchanged after asphyxic hypoxia. Hemic hypoxia had no effect on biogenic monoamine uptake. ATII did not affect uptake of biogenic monoamines in normoxic mice after asphyxic and hemic hypoxia. The results suggest that ATII increases the susceptibility of animals to hypoxia through alterations in the brain high-affinity monoamine uptake.
Stancheva
S
S
Radioisotope Laboratory, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Georgiev
V
V
Alova
L
L
Opitz
M
M
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000493:pharmacokinetics*; D000860:Hypoxia / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009638:Norepinephrine / Q000493:pharmacokinetics*; D012701:Serotonin / Q000493:pharmacokinetics*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine