title: [Immunogenetic study in Mexican couples with recurrent spontaneous abortions].
abstract: OBJECTIVE
  To study the HLA markers in Mexican couples who have suffered three or more spontaneous abortions.
  
  
  METHODS
  The study included 24 couples with recurrent abortions and 32 with normal fertility.
  
  
  METHODS
  HLA class I (A, B, C) and class II (DR, DQ) typing was done with a standard microlymphocytoxity test. The intergroup differences were evaluated by chi-square and the Fisher exact test.
  
  
  RESULTS
  The frequency of the MHC markers in the males and females of couples with abortions were not significantly different from those in fertile couples. However, the abortion couples shared class I antigens more often than expected from random mating as compared to fertile couples, specially in the HLA-B locus. We also found a significantly decreased frequency of the HLA-B7 antigen in males belonging to the abortion group.
  
  
  CONCLUSIONS
  These results suggest that HLA-B antigens may be markers for genes related to pregnancy outcome in Mexicans.
authors.affiliation: Departamento de Genética, Hospital General de México, SS, México, D.F.
authors.forename: B
authors.initials: B
authors.lastname: Silva
authors.forename: J K
authors.initials: JK
authors.lastname: Yamamoto-Furusho
authors.forename: P
authors.initials: P
authors.lastname: Grether
authors.forename: G
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: S
authors.initials: S
authors.lastname: Kofman
authors.forename: J
authors.initials: J
authors.lastname: Granados
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D005298:Fertility / Q000235:genetics / Q000276:immunology; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015793:HLA-B7 Antigen / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D006680:HLA Antigens; D015793:HLA-B7 Antigen