title: A novel RNA-binding motif in influenza A virus non-structural protein 1.
abstract: The solution NMR structure of the RNA-binding domain from influenza virus non-structural protein 1 exhibits a novel dimeric six-helical protein fold. Distributions of basic residues and conserved salt bridges of dimeric NS1(1-73) suggest that the face containing antiparallel helices 2 and 2' forms a novel arginine-rich nucleic acid binding motif.
authors.forename: C Y
authors.initials: CY
authors.lastname: Chien
authors.forename: R
authors.initials: R
authors.lastname: Tejero
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: D E
authors.initials: DE
authors.lastname: Zimmerman
authors.forename: C B
authors.initials: CB
authors.lastname: Ríos
authors.forename: R M
authors.initials: RM
authors.lastname: Krug
authors.forename: G T
authors.initials: GT
authors.lastname: Montelione
mesh_terms: D001665:Binding Sites; D019281:Dimerization; D009980:Influenza A virus / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D012313:RNA / Q000378:metabolism*; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins; D012313:RNA