Novel carbocyclic nucleosides containing a cyclopentyl ring. Adenosine and uridine analogues.
cis-3-Aminomethylcyclopentylmethanol (4) was used as a precursor in the synthesis of carbocyclic nucleosides containing adenine, hypoxanthine, 8-azahypoxanthine, uracil, and 5-iodouracil bases. None of these compounds had appreciable activity against eighteen viruses in the concentration ranges tested. Two of them showed a weak cytostatic activity against three tumor lines.
Balo
C
C
Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago, Spain.
Fernández
F
F
Lens
E
E
López
C
C
Andrei
G
G
Snoeck
R
R
Balzarini
J
J
De CLercq
E
E
D000241:Adenosine / Q000031:analogs & derivatives*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014529:Uridine / Q000031:analogs & derivatives*; D014709:Vero Cells
D000998:Antiviral Agents; D009705:Nucleosides; D000241:Adenosine; D014529:Uridine