title: Synthesis and antibacterial evaluation of [1,3]benzothiazino[3,2-a]quinoline- and [3,1]benzothiazino[1,2-a]quinoline-6-carboxylic acid derivatives.
abstract: A series of [1,3]benzothiazino[3,2-a]quinoline- (5) and [3,1]benzothiazino[1,2-a]quinoline-6-carboxylic acids (10) were synthesized and evaluated for their in vitro antibacterial activity. The activity is discussed in terms of their structural features revealed by molecular orbital correlation.
authors.affiliation: Istituto di Chimica e Tecnologia del Farmaco, Università di Perugia, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Cecchetti
authors.forename: G
authors.initials: G
authors.lastname: Cruciani
authors.forename: E
authors.initials: E
authors.lastname: Filipponi
authors.forename: A
authors.initials: A
authors.lastname: Fravolini
authors.forename: O
authors.initials: O
authors.lastname: Tabarrini
authors.forename: T
authors.initials: T
authors.lastname: Xin
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D013843:Thiazines