[A model of the depressive syndrome in rats induced by the neurotoxin MPTP and autoantibodies to serotonin and dopamine].
Induction of autoantibodies to serotonin and dopamine in blood serum was demonstrated in a new rat model of experimental depression-like syndrome induced by intraperitoneal injection of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 20 mg/kg daily for 12 days). The level and frequency of detection of antibodies to serotonin within 2 and 3 weeks after MPTP withdrawal did not differ, and the level and frequency of detection of antibodies to dopamine were significantly reduced within 3 weeks as compared with 2 weeks after the MPTP withdrawal. In is suggested that disturbances in neuroimmune interactions play an important part in development of depressive states.
Vetrilé
L A
LA
Krupina
N A
NA
Basharova
L A
LA
Kryzhanovskiĭ
G N
GN
Evseev
V A
VA
Orlova
I N
IN
Iordanskaia
T E
TE
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000704:Analysis of Variance; D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000187:drug effects*; D003866:Depressive Disorder / Q000139:chemically induced* / Q000276:immunology; D004195:Disease Models, Animal; D004298:Dopamine / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D008297:Male; D009498:Neurotoxins; D051381:Rats; D017208:Rats, Wistar / Q000276:immunology*; D012701:Serotonin / Q000276:immunology*; D013997:Time Factors
D001323:Autoantibodies; D009498:Neurotoxins; D012701:Serotonin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine