title: Early cognitive and motor symptoms in identified carriers of the gene for Huntington disease.
abstract: OBJECTIVE
  To study early motor and cognitive symptoms in Huntington disease.
  
  
  METHODS
  A follow-up cohort study after a DNA test procedure in which gene carriers and noncarriers were identified among people genetically at risk for Huntington disease.
  
  
  METHODS
  Leiden University Medical Center, Department of Neurology, Leiden, the Netherlands, in cooperation with the Clinical Genetics Center Leiden and the Department of Medical Psychology and Psychotherapy, Erasmus University Rotterdam, Rotterdam, the Netherlands.
  
  
  METHODS
  Thirty-three individuals: 9 unaffected gene carriers, 6 gene carriers with motor symptoms, and 18 noncarriers of the gene for Huntington disease.
  
  
  METHODS
  A neuropsychologic examination covering a broad area of cognitive functioning, reaction time procedures, and motor tasks.
  
  
  RESULTS
  The neuropsychologic assessment showed no significant differences between presymptomatic gene carriers and noncarriers. Three motor tasks differentiated between these 2 groups on a liberal .05 P level (analysis of variance followed by the Student test). The affected gene carriers performed less well than the presymptomatic gene carriers and the noncarriers in 10 motor tasks and 7 cognitive tasks. These differences were significant at P < .05.
  
  
  CONCLUSIONS
  Motor symptoms play a more prominent and unequivocal role than cognitive symptoms in early stages of Huntington disease.
authors.affiliation: Department of Neurology, Leiden University Medical Centre, The Netherlands.
authors.forename: G M
authors.initials: GM
authors.lastname: de Boo
authors.forename: A
authors.initials: A
authors.lastname: Tibben
authors.forename: J B
authors.initials: JB
authors.lastname: Lanser
authors.forename: A
authors.initials: A
authors.lastname: Jennekens-Schinkel
authors.forename: J
authors.initials: J
authors.lastname: Hermans
authors.forename: A
authors.initials: A
authors.lastname: Maat-Kievit
authors.forename: R A
authors.initials: RA
authors.lastname: Roos
mesh_terms: D000328:Adult; D003071:Cognition; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006579:Heterozygote; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009068:Movement; D009483:Neuropsychological Tests; D011597:Psychomotor Performance