Intrinsic control of stem cell fate.
Efforts to expand the number of stem cells ex vivo are based on the assumption that the self-renewal properties of stem cells are subject to extrinsic control. Although loss of stem cell properties ex vivo has been well-documented, conclusive evidence for a gain of stem cell function in vitro has not been forthcoming. In this short discussion paper, some issues related to the self-renewal of stem cells in relation to future experimental strategies are presented.
Lansdorp
P M
PM
Terry Fox Laboratory, British Columbia Cancer Agency, Department of Medicine, University of British Columbia, Vancouver, Canada.
D000818:Animals; D006410:Hematopoiesis / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D051379:Mice