title: Acute affect of mitral calve replacement on extravascular lung water in patients receiving colloid or crystalloid priming of cardiopulmonary bypass.
abstract: Despite numerous studies on extravascular lung water (EVLW) in patients undergoing coronary artery bypass surgery, few data are available on the perioperative time course of EVLW in patients undergoing mitral valve replacement for mitral valve insufficiency (MVI). We have investigated 26 patients undergoing elective mitral valve replacement in order to determine the influence of the preoperative degree of mitral valve insufficiency (degree III or IV) and the effect of different priming solutions for cardiopulmonary bypass. Crystalloid priming with Ringer's lactate was compared with human albumin priming solution. Measurement of EVLW was performed using the thermo-dye dilution technique, before and 1, 6 and 24 h after surgery. Before operation, EVLW is increased significantly in patients with MVI degree IV (MVI-degree IV) compared with patients with degree III (MVI-degree III) and patients undergoing coronary artery bypass surgery. During the postoperative time course a significant decrease in EVLW was observed in patients with MVI-degree IV whereas in patients with MVI-degree III the amount of EVLW did not change. However, compared with patients undergoing coronary artery bypass surgery, EVLW remained above normal in both groups. There was no interaction between the type of priming solution and the postoperative time course of EVLW, and no differences in respiratory variables or duration of mechanical ventilation were observed between groups.
authors.affiliation: Zentrum Anaesthesiologie, Rettungs- und Intensivmedizin der Universität Göttingen, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Buhre
authors.forename: A
authors.initials: A
authors.lastname: Hoeft
authors.forename: B
authors.initials: B
authors.lastname: Schorn
authors.forename: A
authors.initials: A
authors.lastname: Weyland
authors.forename: M
authors.initials: M
authors.lastname: Scholz
authors.forename: H
authors.initials: H
authors.lastname: Sonntag
mesh_terms: D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass; D015633:Extravascular Lung Water / Q000187:drug effects; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D019918:Heart Valve Prosthesis Implantation; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007552:Isotonic Solutions / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000503:physiopathology / Q000601:surgery; D011184:Postoperative Period; D015532:Rehydration Solutions / Q000494:pharmacology; D000077325:Ringer's Lactate; D012709:Serum Albumin / Q000494:pharmacology
chemical_list: D007552:Isotonic Solutions; D015532:Rehydration Solutions; D000077325:Ringer's Lactate; D012709:Serum Albumin