title: [Influence of bitumen on burn wounds and their surrounding skin in guinea-pigs].
abstract: This study assessed the topical effects of bitumen on burn wounds and their surrounding skin in guinea-pigs. It consisted of three different experiments. The bitumen used in this experiment was a soft tar produced by Daye Steel Plant. The first experiment showed that the skin of the bitumen group marked pathological changes under both light and electron microscopes. The second experiment suggested that healing of the burn wounds of bitumen group was delayed, and less hair follicle counts and a lower intradermal thickness were found as compared with the other groups. The third experiment indicated that the wound edges had been seriously destroyed by bitumen, leading to enlargement of the size of the ulcers, and hypertrophy of scar occurred after healing. It is concluded that bitumen, especially the soft coal tar, has more errosive, irritating and destructive effects, therefore in bitumen burns the bitumen must be immediately and entirely removed from burn wounds.
authors.affiliation: Department of Bitumen Burn Research, Huangshi 2nd Hospital, Huangshi.
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: W
authors.initials: W
authors.lastname: Mo
authors.forename: J
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002057:Burns, Chemical / Q000503:physiopathology*; D017439:Cicatrix, Hypertrophic / Q000139:chemically induced*; D006168:Guinea Pigs; D006838:Hydrocarbons / Q000009:adverse effects*; D008297:Male; D014945:Wound Healing
chemical_list: D006838:Hydrocarbons; C006647:asphalt