Comparisons of prolonged sevoflurane, isoflurane, and halothane anaesthesia combined with nitrous oxide in spontaneously breathing cats.
The clinical, cardiopulmonary, haematologic, and serum biochemical effects of sevoflurane, isoflurane and halothane anaesthesia with 66% nitrous oxide, were compared in healthy, premedicated cats breathing spontaneously during 6 h of anaesthesia. Recovery time from anaesthesia with sevoflurane-nitrous oxide was more rapid than that with halothane-nitrous oxide, but it does not differ from that with isoflurane-nitrous oxide. The degree of respiratory acidosis with sevoflurane-nitrous oxide anaesthesia was similar to that with isoflurane-nitrous oxide and was less than that with halothane-nitrous oxide. There were no significant differences among the groups in the heart rate, arterial pressures, haematological and serum biochemical values. The three anaesthetic regimens induced a similar degree of hyperglycemia during anaesthesia. Serum biochemical examination did not reveal apparent hepatic or renal injuries after each anaesthesia. Time-related increases in respiration rate and arterial carbon dioxide partial pressure were observed during prolonged halothane-nitrous oxide anaesthesia. No significant time-related changes in cardiopulmonary variables were observed during either sevoflurane- or isoflurane-nitrous oxide anaesthesia. Therefore, sevoflurane-nitrous oxide may be used as an effective and safe anaesthetic combination similar to isoflurane-nitrous oxide for long-term anaesthesia in healthy cats.
Hikasa
Y
Y
Department of Veterinary Medicine, Faculty of Agriculture, Tottori University.
Yoshikai
T
T
Takase
K
K
Ogasawara
S
S
D000769:Anesthesia, Inhalation / Q000379:methods / Q000662:veterinary; D019162:Anesthetics, Combined / Q000008:administration & dosage / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002415:Cats / Q000502:physiology*; D004987:Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006221:Halothane / Q000008:administration & dosage / Q000494:pharmacology*; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008738:Methyl Ethers; D009609:Nitrous Oxide / Q000008:administration & dosage / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D000077149:Sevoflurane
D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D009609:Nitrous Oxide; D006221:Halothane