title: Seizures, ventricular tachycardia, and rhabdomyolysis as a result of ingestion of venlafaxine and lamotrigine.
abstract: Few cases of overdoses have been described involving venlafaxine, lamotrigine, or a combination of the two agents. We describe a combined venlafaxine and lamotrigine ingestion in a patient presenting with a seizure, ventricular tachycardia, and rhabdomyolysis. We conclude that patients with overdoses that involve venlafaxine can exhibit severe cardiac effects in addition to seizures, especially if venlafaxine is combined with other agents.
authors.affiliation: Department of Nephrology, Rush Presbyterian St. Luke's Medical Center, Chicago, IL, USA.
authors.forename: C
authors.initials: C
authors.lastname: Peano
authors.forename: J B
authors.initials: JB
authors.lastname: Leikin
authors.forename: P K
authors.initials: PK
authors.lastname: Hanashiro
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000506:poisoning*; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D003511:Cyclohexanols / Q000506:poisoning*; D004562:Electrocardiography / Q000187:drug effects; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced*; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D013406:Suicide, Attempted; D017180:Tachycardia, Ventricular / Q000139:chemically induced*; D014227:Triazines / Q000506:poisoning*; D000069470:Venlafaxine Hydrochloride
chemical_list: D000927:Anticonvulsants; D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D014227:Triazines; D000069470:Venlafaxine Hydrochloride; D000077213:Lamotrigine