title: [The correction of the vaginal microflora in patients with a papillomavirus infection associated with cervical intraepithelial neoplasia by using the new bacterial preparation Zhlemik].
abstract: The microbiological study of vaginal microflora in 40 patients of the reproductive age (20-30 years) with papilloma virus infection in association with cervical intraepithelial neoplasia of the uterine neck revealed dysbiotic disturbances in vaginal microflora, manifested by a decrease in the isolation rate and amount of lacto- and bifidobacteria and by excessive growth of opportunistic microorganisms. The 10-day course of corrective therapy with the new bacterial preparation "Zhlemik" was carried out. Group 1 (81 women) received the preparation intravaginally on a tampon, group 2 (19 patients) received the preparation in the form of vaginal suppositories. The results of this treatment were indicative of a high sanative effect of the preparation irrespective of the method of its application. This was demonstrated by the results of the bacteriological study made after bacterial correction: the amount of the Lactobacillus was restored, and they could be isolated from all patients; the level of contamination of the cervicovaginal niche with opportunistic microbial strains considerably decreased. The positive clinical effect after bacterial therapy with "Zhlemik" was observed in 93-95% of cases, depending on the form of its application.
authors.forename: V M
authors.initials: VM
authors.lastname: Korshunov
authors.forename: L I
authors.initials: LI
authors.lastname: Kafarskaia
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Bagirova
authors.forename: O V
authors.initials: OV
authors.lastname: Korshunova
authors.forename: G N
authors.initials: GN
authors.lastname: Minkina
authors.forename: I B
authors.initials: IB
authors.lastname: Manukhin
mesh_terms: D000328:Adult; D001419:Bacteria / Q000302:isolation & purification; D001430:Bacteriocins / Q000627:therapeutic use*; D003218:Condylomata Acuminata / Q000382:microbiology / Q000628:therapy; D005260:Female; D006801:Humans; D007778:Lactobacillus; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000382:microbiology / Q000628:therapy*; D012074:Remission Induction; D014412:Tumor Virus Infections / Q000382:microbiology / Q000628:therapy*; D002577:Uterine Cervical Diseases / Q000382:microbiology / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000382:microbiology / Q000628:therapy*; D014621:Vagina / Q000382:microbiology*; D002578:Uterine Cervical Dysplasia / Q000382:microbiology / Q000628:therapy*
chemical_list: D001430:Bacteriocins; C066526:zhlemik