Alzheimer's disease: risk and protection.
Only four risk factors for Alzheimer's disease can be regarded as confirmed--old age, family history of dementia, apo-E genotype and Down syndrome. Other disputed risk factors with some supporting evidence include ethnic group, head trauma and aluminium in drinking water. Possible protection factors, such as anti-inflammatory drugs, oestrogen replacement therapy and a high education level, are of great interest because they suggest possible preventive action.
Jorm
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National Health and Medical Research Centre Psychiatric Epidemiology Research Centre, Australian National University, Canberra, ACT. Anthony.Jorm@anu.edu.au
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000535:Aluminum / Q000506:poisoning; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001057:Apolipoproteins E / Q000235:genetics; D006259:Craniocerebral Trauma / Q000453:epidemiology; D004314:Down Syndrome / Q000453:epidemiology; D004522:Educational Status; D015914:Estrogen Replacement Therapy; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D007360:Intelligence; D008297:Male; D015995:Prevalence; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001057:Apolipoproteins E; D000535:Aluminum