[Effects of amiloride and glycogen depletion on post-ischemic reperfusion injury of isovolumic perfused rat hearts].
The effects of amiloride (0.5 nmol/L) and glycogen depletion were studied to find out the possible roles of Na(+)-H+ exchange of ischemia reperfusion injury in the isovolumic perfused isolated rat hearts. The data indicated that, compared to control group, both amiloride and glycogen depletion accelerated recovery of hemodynamics and reduced leakage of LDH and the formation of myocardial MDA which was accompared by a higher activity of mitochondrial GSH-Px and lesser accumulation of intracellular Na+, Ca2+. That Na(+)-H+ and Na(+)-Ca2+ exchanges might play a critical role in post-ischemic reperfusion injury is discussed.
Zhao
T C
TC
Department of Pathophysiology, Xinxiang Medical College.
Zhang
X L
XL
Shi
A Y
AY
Xu
H
H
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D006003:Glycogen / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D019831:Sodium-Calcium Exchanger / Q000502:physiology; D017923:Sodium-Hydrogen Exchangers / Q000502:physiology
D004232:Diuretics; D019831:Sodium-Calcium Exchanger; D017923:Sodium-Hydrogen Exchangers; D000584:Amiloride; D006003:Glycogen