Chemopreventive effects of sandalwood oil on skin papillomas in mice.
The essential oil, emulsion or paste of sandalwood (Santalum album L) has been used in India as an ayurvedic medicinal agent for the treatment of inflammatory and eruptive skin diseases. In this investigation, the chemopreventive effects of sandalwood oil (5% in acetone, w/v) on 7,12-dimethylbenz(a)anthracene-(DMBA)-initiated and 12-O-tetradecanoyl phorbol-13-acetate(TPA)-promoted skin papillomas, and TPA-induced ornithine decarboxylase (ODC) activity in CD1 mice were studied. Sandalwood oil treatment significantly decreased papilloma incidence by 67%, multiplicity by 96%, and TPA-induced ODC activity by 70%. This oil could be an effective chemopreventive agent against skin cancer.
Dwivedi
C
C
College of Pharmacy, South Dakota State University, Brookings 57007-0099, USA.
Abu-Ghazaleh
A
A
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D018890:Chemoprevention; D016009:Chi-Square Distribution; D003374:Coumarins / Q000627:therapeutic use*; D004195:Disease Models, Animal; D015994:Incidence; D051379:Mice; D008815:Mice, Inbred Strains; D016017:Odds Ratio; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010212:Papilloma / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D010938:Plant Oils / Q000627:therapeutic use*; D012016:Reference Values; D012717:Sesquiterpenes / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*; D015996:Survival Rate
D003374:Coumarins; D010938:Plant Oils; D012717:Sesquiterpenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D009955:Ornithine Decarboxylase; C076763:sandalwood oil