[Morphological and functional correlations of the protective action of pantothenic acid in cisplatin ototoxicity (I)].
The protective effect of pantothenic acid and coenzyme A on cisplatin-induced ototoxicity in guinea pigs has been demonstrated. We studied the possible correspondence between functional disturbances studied by electrocochleography, specifically the latency of the N1 wave and morphological abnormalities on scanning electron microscopy. Statistical analysis showed no correspondence.
Martínez Martínez
M J
MJ
Facultad de Medicina, Universidad de Granada.
Fernández Cervilla
F
F
Crespo
V P
VP
Giges
M
M
Campos
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects* / Q000648:ultrastructure; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000517:prevention & control*; D010205:Pantothenic Acid / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D010205:Pantothenic Acid; D002945:Cisplatin