title: Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold.
authors.affiliation: Department of Chemistry and Interdepartmental Program in Biochemistry and Molecular Biology, University of California, Santa Barbara, California 93106, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Perona
authors.forename: C S
authors.initials: CS
authors.lastname: Craik
mesh_terms: D001224:Aspartic Acid / Q000737:chemistry; D001665:Binding Sites; D002918:Chymotrypsin / Q000737:chemistry; D006639:Histidine / Q000737:chemistry; D008239:Lysine / Q000737:chemistry; D011487:Protein Conformation; D012694:Serine / Q000737:chemistry; D012697:Serine Endopeptidases / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014357:Trypsin / Q000737:chemistry
chemical_list: D001224:Aspartic Acid; D012694:Serine; D006639:Histidine; D012697:Serine Endopeptidases; D002918:Chymotrypsin; D014357:Trypsin; D008239:Lysine