Errors of homeostasis and deregulated apoptosis.
Apoptosis research has accelerated with the discovery of genes within a common cell death pathway and evidence for their inter-relationship. Breakthroughs include insights into the mechanism of action of the Bcl-2 family, caspases and their targets, and death receptor complexes. Deregulation of apoptosis is evident in tumors and viral infection, as well as in autoimmune disease, immunodeficiency, neurodegeneration, and infertility.
Rinkenberger
J L
JL
Department of Anatomy, University of California, San Francisco 94143-0750, USA. rinken@itsa.ucsf.edu
Korsmeyer
S J
SJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001327:Autoimmune Diseases / Q000473:pathology / Q000503:physiopathology; D003546:Cysteine Endopeptidases / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007246:Infertility; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology; D009410:Nerve Degeneration / Q000473:pathology / Q000503:physiopathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology; D014777:Virus Diseases / Q000473:pathology / Q000503:physiopathology
D019253:Proto-Oncogene Proteins c-bcl-2; D011956:Receptors, Cell Surface; D003546:Cysteine Endopeptidases