[The neurobiological bases of epileptogenesis in the developing brain].
The basics of neurophysiological, neurochemical and molecular mechanisms of epileptogenesis in early ontogeny are discussed. The role of developmental neuropathology, synaptogenesis; the role of glutamatergic and GABA-ergic transmitter systems are summarized. The candidates of genes in the childhood epilepsies, developmental changes in the expression of genes of voltage-gated ionic channels and receptor genes are reviewed.
Chepurnov
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Chepurnova
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D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development*; D004195:Disease Models, Animal; D004827:Epilepsy / Q000196:embryology / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D018846:Excitatory Amino Acids / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology; D006801:Humans; D007696:Kindling, Neurologic / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D009474:Neurons / Q000502:physiology; D017470:Receptors, Glutamate / Q000235:genetics / Q000502:physiology; D013569:Synapses / Q000502:physiology
D018846:Excitatory Amino Acids; D017470:Receptors, Glutamate