title: L-Myc overexpression and detection of auto-antibodies against L-Myc in both the serum and pleural effusion from a patient with non-small cell lung cancer.
abstract: Non-small cell lung cancer patient was found to have auto-antibodies against L-Myc in both the serum and pleural effusion. The titer of anti-L-Myc antibodies was higher in the pleural effusion than in the serum. Overexpression of L-Myc without DNA amplification was observed in the tumor cells. L-Myc antigen was not detected in either the serum or the pleural effusion. Anti-nuclear antibodies were also detected in both the serum and pleural effusion, although this patient did not have collagen-vascular disease.
authors.affiliation: Third Department of Internal Medicine, Tokushima University School of Medicine.
authors.forename: A
authors.initials: A
authors.lastname: Yamamoto
authors.forename: E
authors.initials: E
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Sumitomo
authors.forename: A
authors.initials: A
authors.lastname: Shinohara
authors.forename: O
authors.initials: O
authors.lastname: Namikawa
authors.forename: H
authors.initials: H
authors.lastname: Uehara
authors.forename: S
authors.initials: S
authors.lastname: Sone
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D014408:Biomarkers, Tumor; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015342:DNA Probes / Q000737:chemistry; D004273:DNA, Neoplasm / Q000276:immunology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016066:Pleural Effusion, Malignant / Q000097:blood / Q000276:immunology*; D016271:Proto-Oncogene Proteins c-myc / Q000276:immunology* / Q000378:metabolism*
chemical_list: D001323:Autoantibodies; D014408:Biomarkers, Tumor; D015342:DNA Probes; D004273:DNA, Neoplasm; D016271:Proto-Oncogene Proteins c-myc