Overexpression of A-myb induces basic fibroblast growth factor-dependent proliferation of chicken neuroretina cells.
A-Myb behaves similarly to c-Myb in chicken neuroretina cells in its ability to induce fibroblast-like differentiation, to promote growth in the presence of basic fibroblast growth factor (bFGF), and to induce Pax-6 and mim-1 expression. The one difference between c-Myb and A-Myb in these cells is that the former but not the latter protein causes colony formation in soft agar in the presence of bFGF.
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CNRS EP560, Institut Pasteur de Lille, France.
Plaza
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Klempnauer
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Saule
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D000123:Acetyltransferases; D000818:Animals; D030161:Avian Proteins; D002455:Cell Division; D002460:Cell Line; D002645:Chickens; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics; D005136:Eye Proteins; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D015870:Gene Expression; D018398:Homeodomain Proteins; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011401:Promoter Regions, Genetic; D014176:Protein Biosynthesis; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D020598:Proto-Oncogene Proteins c-myb; D012097:Repressor Proteins; D015534:Trans-Activators / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism
C490284:A-MYB protein, chicken; D030161:Avian Proteins; D004268:DNA-Binding Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D012097:Repressor Proteins; D015534:Trans-Activators; D016222:Fibroblast Growth Factor 2; D000123:Acetyltransferases; C077509:mim-1 protein, Gallus gallus