title: ["State-of-the-art" chemotherapy for small-cell lung cancer].
abstract: A combination of etoposide and cisplatin (EP) is the current standard chemotherapy for small-cell lung cancer (SCLC). A combined modality-treatment of EP and thoracic irradiation has been established as the standard therapy for limited disease (LD)-SCLC. To improve further the results of treatment for SCLC, it is necessary to reconsider a new non-cross resistant alternating chemotherapy including promising new agents in LD-SCLC. A new maintenance chemotherapy with new agents should also be studied again. In extensive disease (ED)-SCLC, there were few long-term survivors in spite of aggressive chemotherapy. It is important to develop a new combination chemotherapy including new agents (irinotecan, topotecan, paclitaxel, docetaxel, and gemcitabine).
authors.affiliation: Dept. of Respiratory Medicine, Osaka City General Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Negoro
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018288:Carcinoma, Small Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077143:Docetaxel; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives; D043823:Taxoids; D019772:Topotecan / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage; D000093542:Gemcitabine
chemical_list: D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; D014750:Vincristine; D005047:Etoposide; D000077146:Irinotecan; D019772:Topotecan; D004317:Doxorubicin; D003520:Cyclophosphamide; D017239:Paclitaxel; D002945:Cisplatin; D002166:Camptothecin; D000093542:Gemcitabine