[Allergic contact dermatitis to nickel: modification of receptor expression on peripheral lymphocytes of women after oral provocation tests (preliminary data)].
Blood lymphocyte subset evaluation was performed before after oral challenge with 10 mg of Ni, in 9 healthy women and in 15 allergic to Ni. Following challenge, 7 allergic showed a flare up of eczema and/or urticaria. In the controls, CD4+ lymphocytes were modified 24 hours after Ni challenge: CD4+/CD44RO- "virgin" cells were reduced while CD4+/CD45RO+ "memory" cells increased. The allergic women, not sensitive to oral Ni, showed an increase of B lymphocytes after the test. On the contrary, the oral Ni reacting patients presented a reduction of monocytes 4 hours after Ni ingestion and marked reduction (ranging from 20 to 50%) of T and B lymphocytes after 24 hours. These significant T and B lymphocytes changes suggest a migration of the cells in peripheral tissues, likely skin and GUT mucosa.
Di Gioacchino
M
M
Immunologia Clinica ed Allergologia, Centro di Medicina del Lavoro ed Ergoftalmologia, Università G. D'Annunzio. Chieti.
Andreassi
M
M
Boscolo
P
P
Cervone
M
M
Bavazzano
P
P
Gravante
M
M
Pavone
G
G
Cavallucci
E
E
Ramondo
S
S
Schiappoli
M
M
Verna
N
N
Masci
S
S
Amerio
P
P
Giuliano
G
G
D000284:Administration, Oral; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000145:classification / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology; D004485:Eczema / Q000139:chemically induced* / Q000276:immunology; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D017493:Leukocyte Common Antigens / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D018655:Lymphocyte Count; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D009532:Nickel / Q000008:administration & dosage / Q000009:adverse effects* / Q000652:urine; D016176:T-Lymphocyte Subsets / Q000276:immunology; D015854:Up-Regulation; D014581:Urticaria / Q000139:chemically induced* / Q000276:immunology
D009532:Nickel; D017493:Leukocyte Common Antigens