title: Human endometrial cancers contain follicle-stimulating hormone receptors: a preliminary study.
abstract: In order to investigate whether human endometrial cancers contain follicle-stimulating hormone (FSH) receptors, cancer fragments were collected at hysterectomy in six post-menopausal women affected by histologically confirmed endometrial malignancy. Cryostat sections were prepared for in situ binding investigation. Positive endometrial glandular cells were registered in all cancers; 125I-FSH binding sites seemed to increase with the increasing tumor grade. Our data demonstrated for the first time that human endometrial cancers contain specific FSH receptors.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Florence, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Noci
authors.forename: P
authors.initials: P
authors.lastname: Borri
authors.forename: G L
authors.initials: GL
authors.lastname: Taddei
authors.forename: D
authors.initials: D
authors.lastname: Moncini
authors.forename: T
authors.initials: T
authors.lastname: Barni
authors.forename: G B
authors.initials: GB
authors.lastname: Vannelli
mesh_terms: D000368:Aged; D001345:Autoradiography; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000601:surgery; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007044:Hysterectomy; D007457:Iodine Radioisotopes; D008875:Middle Aged; D017698:Postmenopause; D011962:Receptors, FSH / Q000032:analysis*
chemical_list: D007457:Iodine Radioisotopes; D011962:Receptors, FSH; D005640:Follicle Stimulating Hormone