Prior brain injury protects death from local anaesthetic-induced convulsion.
Minor brain injury was inflicted with a small hypodermic needle at four sites from the scalp 7 days before the production of convulsion by i.p. injection of 100 mg/kg lidocaine in mice. The latency to convulsion and survival rate were significantly longer and higher, respectively, in the brain-injured group than in the sham-operated one. Thus, the results suggest that a protective mechanism develops in the injured brain against asphyxia caused by lidocaine convulsion.
Endoh
H
H
Department of Anaesthesia, Niigata City Hospital, Niigata, Japan.
Kumagai
Y
Y
Baba
H
H
Yamakura
T
T
Taga
K
K
Sato
K
K
Fukuda
S
S
Shimoji
K
K
D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D001930:Brain Injuries / Q000150:complications*; D008012:Lidocaine / Q000633:toxicity*; D008297:Male; D051379:Mice; D011930:Reaction Time / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000401:mortality*; D015996:Survival Rate
D000779:Anesthetics, Local; D008012:Lidocaine