[Analgesic action of microinjection of neurokinin A into the lateral reticular nucleus and nucleus raphe magnus in rats].
Using the microinjection technique, the analgesic effect of neurokinin A (NKA) microinjected into the lateral reticular nucleus (LRN) and nucleus raphe magnus (NRM) was investigated in lightly pentobarbital-anesthetized rats using tail flick latency (TFL) as an index. Microinjection of NKA (0.5 microgram/0.5 microliter) into LRN significantly increased TFL lasting for 10 min (n = 12, P < 0.001). Microinjection of the same amount of NKA into NRM also produced evident increase in TFL for 5 min (n = 13, P < 0.001). The results indicate that NKA modulates pain reaction in both LRN and NRM in rats.
Yan
G P
GP
Air Force Tianjin Hospital.
Zhao
Y
Y
Huang
Q E
QE
Chen
W M
WM
D015667:Acupuncture Analgesia; D000818:Animals; D015671:Electroacupuncture; D008845:Microinjections; D015288:Neurokinin A / Q000494:pharmacology*; D017288:Pain Threshold; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012154:Reticular Formation / Q000502:physiology*
D015288:Neurokinin A