title: Differentiation commitment in normal hemopoiesis and leukemic transformation.
abstract: Differentiation commitment events are essential for the initiation of hemopoiesis and, in one form or another, occur continuously during adult hemopoiesis. The most studied type of differentiation commitment decision a hemopoietic cell can make involves the alternative choice of self-renewal versus the formation of progeny destined for maturation. Aberration in this commitment choice is a key abnormality necessary for the formation of a leukemic population.
authors.affiliation: Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Metcalf
authors.forename: N A
authors.initials: NA
authors.lastname: Nicola
authors.forename: L
authors.initials: L
authors.lastname: Robb
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D006410:Hematopoiesis / Q000502:physiology*; D007942:Leukemia, Experimental / Q000473:pathology / Q000503:physiopathology*; D012016:Reference Values