title: Cone ERG subnormality to red flash in central retinal vein occlusion: a predictor of ocular neovascularisation?
abstract: In patients with unilateral central retinal vein occlusion (CRVO), we retrospectively examined whether cone electroretinogram (ERG) subnormality to red flash (ratio of the b-wave amplitude in the CRVO eye to that in the normal fellow eye < 1) found at the time of diagnosis of the CRVO was a predictor of later ocular neovascularisation. Ganzfeld ERG cone and rod responses had initially been obtained in a consecutive series of 21 patients with unilateral CRVO. Patients were re-evaluated 6-55 months later to determine whether ocular neovascularisation had developed. Of the 21 CRVO eyes, 6 (29%) were subnormal to red in the affected compared with the normal fellow eye. At follow-up, all 6 (100%) patients had developed ocular neovascularisation compared with 1 (7%) of the 15 patients who were supernormal to red (p = 0.00013). Cone ERG subnormality to red flash in CRVO eyes compared with normal fellow eyes may be a predictor of later development of ocular neovascularisation.
authors.affiliation: UMDNJ-New Jersey Medical School, Department of Ophthalmology, Newark 07103-2499, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Roy
authors.forename: C J
authors.initials: CJ
authors.lastname: Mackay
authors.forename: P
authors.initials: P
authors.lastname: Gouras
mesh_terms: D000221:Adaptation, Ocular / Q000502:physiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003116:Color; D004596:Electroretinography; D005123:Eye / Q000098:blood supply*; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D010775:Photic Stimulation; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology* / Q000528:radiation effects; D012170:Retinal Vein Occlusion / Q000503:physiopathology*; D012189:Retrospective Studies