Distribution and photodynamic effect of zinc phthalocyanine disulfonate in nude mice bearing mammary carcinoma.
The distribution study of zinc phthalocyanine disulfonate (ZnPcS2) in nude mice bearing mammary carcinoma (T50/80) revealed a rapid uptake of the dye by tumor. In experimental photodynamic therapy (PDT), the tumors were exposed to laser radiation (670 nm, 100 mW/cm2, 150 J/ /cm2) after intravenous administration of ZnPcS2 in saline. The results showed the maximum tumor destruction to be achieved for the time interval between injection of the drug (2 mg/kg) and exposure to laser light of 5 min, while a significantly less damage was observed when the time interval was 24 h (p < 0.0001). The degree of damage produced by the treatment was monitored in vivo by means of noninvasive NMR-imaging and subsequently confirmed histologically.
Mosa
M
M
Institute of Biophysics, First Medical Faculty, Charles University, Prague, Czech Republic.
Zitko
M
M
Poucková
P
P
D000818:Animals; D005260:Female; D007211:Indoles / Q000493:pharmacokinetics* / Q000494:pharmacology; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009336:Necrosis; D009942:Organometallic Compounds / Q000493:pharmacokinetics* / Q000494:pharmacology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D007211:Indoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C064329:zinc phthalocyanine disulfonate