[Possible mechanism of the analgesic effect of interleukin-2 in central nervous system].
The monoclonal antibody against IL-2R (Tac) could not block the analgesic effect of IL-2, and IL-2 mutant that could not bind to beta subunit of IL-2 receptor still had capability of increasing the pain threshold of rats. All these facts suggest that the analgesic effect of IL-2 in CNS is not mediated through the IL-2 receptor, and that the immune and analgesic effects of IL-2 are mediated through different receptor mechanisms. It is suggested that there are common antigenic determinants and similar structure between IL-2 and endogenous opioid peptides (EOP). This implies that the analgesic effect of IL-2 might be mediated by interaction between IL-2 and opioid receptors in CNS. Using radioimmunoassay the contents of EOP of different nuclei were measured at different times after injecting IL-2 into the lateral ventricle of rats. The results suggested that the analgesic effect of IL-2 may be related to beta-EP and LEK in arcuate hypothalamic nucleus, paraventricular hypothalamic nucleus and locus ceruleus.
Jiang
C L
CL
Department of Neurobiology, Second Military Medical University, Shanghai.
Xu
D
D
You
Z D
ZD
Wang
A J
AJ
Song
C Y
CY
Wang
C H
CH
Liu
X Y
XY
Lu
C L
CL
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004743:Enkephalin, Leucine / Q000502:physiology; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D018847:Opioid Peptides / Q000502:physiology; D017288:Pain Threshold; D051381:Rats; D017207:Rats, Sprague-Dawley; D011957:Receptors, Opioid / Q000502:physiology*
D018712:Analgesics, Non-Narcotic; D007376:Interleukin-2; D018847:Opioid Peptides; D011957:Receptors, Opioid; D004743:Enkephalin, Leucine