title: Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia.
authors.affiliation: Neurological and Urological Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Meyer
authors.forename: R J
authors.initials: RJ
authors.lastname: Altenbach
authors.forename: F Z
authors.initials: FZ
authors.lastname: Basha
authors.forename: W A
authors.initials: WA
authors.lastname: Carroll
authors.forename: I
authors.initials: I
authors.lastname: Drizin
authors.forename: S W
authors.initials: SW
authors.lastname: Elmore
authors.forename: P P
authors.initials: PP
authors.lastname: Ehrlich
authors.forename: S A
authors.initials: SA
authors.lastname: Lebold
authors.forename: K
authors.initials: K
authors.lastname: Tietje
authors.forename: K B
authors.initials: KB
authors.lastname: Sippy
authors.forename: M D
authors.initials: MD
authors.lastname: Wendt
authors.forename: D J
authors.initials: DJ
authors.lastname: Plata
authors.forename: F
authors.initials: F
authors.lastname: Plagge
authors.forename: S A
authors.initials: SA
authors.lastname: Buckner
authors.forename: M E
authors.initials: ME
authors.lastname: Brune
authors.forename: A A
authors.initials: AA
authors.lastname: Hancock
authors.forename: J F
authors.initials: JF
authors.lastname: Kerwin
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D004285:Dogs; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D054833:Isoindoles; D008297:Male; D008956:Models, Chemical; D011224:Prazosin / Q000031:analogs & derivatives / Q000627:therapeutic use; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000627:therapeutic use; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1; D013449:Sulfonamides / Q000627:therapeutic use; D000077409:Tamsulosin
chemical_list: C108685:A 131701; C547713:ADRA1A protein, human; D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D007211:Indoles; D054833:Isoindoles; D011744:Pyrimidinones; D018340:Receptors, Adrenergic, alpha-1; D013449:Sulfonamides; C041226:Terazosin; D000077409:Tamsulosin; D011224:Prazosin