Myositis associated with graft-versus-host disease.
A polymyositis syndrome has been described as a rare complication in patients who develop chronic graft-versus-host disease after allogeneic bone marrow transplantation. Chronic graft-versus-host disease is a cellular immune-mediated donor bone marrow versus patient rejection reaction, which may also lead to an autoimmune pathologic process. Chronic graft-versus-host disease-related polymyositis appears to be very similar to idiopathic myositis in its clinicopathologic presentation; chronic graft-versus-host disease-related myositis responds well to prednisone but cyclosporine may be an important component of second-line therapy due to its efficacy in controlling underlying chronic graft-versus-host disease.
Parker
P M
PM
Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010-3000, USA.
Openshaw
H
H
Forman
S J
SJ
D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003937:Diagnosis, Differential; D006086:Graft vs Host Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D009220:Myositis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*