[Effects of inflammatory mediators on the release of CGRP from isolated mesenteric arterial bed of rat].
The purpose of the present study was to observe whether inflammatory mediators, such as: Prostaglandin E2 (PGE2), Bradykinin (BK), Histamine (HIS), Platelet active factor (PAF) and 5-hydroxytryptamine (5-HT), directly triggered the release of CGRP from perivascular nerves in isolated rat mesenteric arterial bed. The results showed that PGE2 (1-100 mumol/L) and BK (5-10 mumol/L) caused time- and concentration-dependent CGRP release, but HIS, PAF and 5-HT did not show significant effects. Our data indicate that PGE2 and BK are the major inflammatory mediators in triggering the release of CGRP from the perivascular CGRP-containing nerve.
Wu
Z X
ZX
Third Hospital, Beijing Medical University.
Tang
Y M
YM
Han
Q D
QD
Wang
X
X
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D015232:Dinoprostone / Q000494:pharmacology; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000494:pharmacology*; D008297:Male; D008638:Mesenteric Arteries / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D018836:Inflammation Mediators; D015740:Calcitonin Gene-Related Peptide; D015232:Dinoprostone; D001920:Bradykinin