Developmental signaling: notch signals Kuz it's cleaved.
Recent experiments with Kuzbanian, a disintegrin metalloprotease that is required during development for lateral inhibitory signaling, suggest that signaling molecules of the Notch family may guide cell fate only after they are activated by proteolysis, and that the proteolysis may be catalyzed by Kuzbanian.
Nye
J S
JS
Department of Molecular Pharmacology, Northwestern University, Chicago, Illinois 60611, USA.
D019483:Disintegrins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D006868:Hydrolysis; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051880:Receptors, Notch; D015398:Signal Transduction / Q000235:genetics
D019483:Disintegrins; D029721:Drosophila Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; C100953:KUZ protein, Drosophila; D008666:Metalloendopeptidases