title: Persistent high MR signal of the posterior pituitary gland in central diabetes insipidus.
abstract: We describe three cases of central diabetes insipidus, each with a different pathogenesis, in which unexpected hyperintensity of the posterior pituitary gland was seen on T1-weighted MR images obtained at the time of presentation. In the first case (idiopathic), the posterior pituitary signal persisted more than 10 years; in the second case (Langerhans cell histiocytosis), the signal disappeared within 3 months, despite early specific chemotherapy with etoposide; and in the third case (transient), the posterior signal disappeared within 1 year, but it was documented at the time of spontaneous reversal of polyuria and polydipsia.
authors.affiliation: Department of Pediatrics, University, IRCCS Policlinico S. Matteo, Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Maghnie
authors.forename: E
authors.initials: E
authors.lastname: Genovese
authors.forename: S
authors.initials: S
authors.lastname: Bernasconi
authors.forename: S
authors.initials: S
authors.lastname: Binda
authors.forename: M
authors.initials: M
authors.lastname: Aricò
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003919:Diabetes Insipidus / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D010903:Pituitary Gland, Anterior / Q000473:pathology; D010904:Pituitary Gland, Posterior / Q000473:pathology*; D014882:Water-Electrolyte Balance / Q000502:physiology