[Effects of melatonin and diazepam on the eye movement and postural muscle tone in decerebrate cats].
We studied the effects of melatonin and diazepam on eye movement and muscle activity in decerebrate cats, and results were compared with those obtained from carbachol injection into the pontine reticular formation which was supposed to be a model of REM sleep. In precollicular postmammillary decerebrate cats, the horizontal eye movement and the activity of bilateral triceps surae muscles were recorded under three conditions: (1) microinjection of carbachol into the rostral pontine reticular formation; (2) intravenous administration melatonin; and (3) diazepam. Both rapid eye movement and reduction of muscle activity were induced by carbachol injection, while only reduction of muscle activity was induced by diazepam administration. Neither rapid eye movement nor reduction of muscle activity was induced by melatonin administration in this animal preparation. From these results, we speculated that the inhibitory effect of diazepam on muscle tonus was not manifested through activation of the brainstem REM generating system. It is known that the melatonin receptors are located in several sites of central nervous system, such as suprachiasmatic nucleus, and not in the brainstem and spinal cord. The present results of melatonin administration may support this fact in view of behavioral aspects.
Tanaka
H
H
Department of Pediatrics, Asahikawa Habilitation Center for Disabled Children, Japan.
Takakusaki
K
K
Oki
J
J
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002415:Cats; D003655:Decerebrate State; D003975:Diazepam / Q000494:pharmacology*; D005133:Eye Movements / Q000187:drug effects*; D008550:Melatonin / Q000494:pharmacology*; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009129:Muscle Tonus / Q000187:drug effects*; D011187:Posture; D012895:Sleep, REM / Q000502:physiology
D009125:Muscle Relaxants, Central; D002217:Carbachol; D008550:Melatonin; D003975:Diazepam