title: [Effects of inflammatory mediators on the release of CGRP from isolated mesenteric arterial bed of rat].
abstract: The purpose of the present study was to observe whether inflammatory mediators, such as: Prostaglandin E2 (PGE2), Bradykinin (BK), Histamine (HIS), Platelet active factor (PAF) and 5-hydroxytryptamine (5-HT), directly triggered the release of CGRP from perivascular nerves in isolated rat mesenteric arterial bed. The results showed that PGE2 (1-100 mumol/L) and BK (5-10 mumol/L) caused time- and concentration-dependent CGRP release, but HIS, PAF and 5-HT did not show significant effects. Our data indicate that PGE2 and BK are the major inflammatory mediators in triggering the release of CGRP from the perivascular CGRP-containing nerve.
authors.affiliation: Third Hospital, Beijing Medical University.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Wu
authors.forename: Y M
authors.initials: YM
authors.lastname: Tang
authors.forename: Q D
authors.initials: QD
authors.lastname: Han
authors.forename: X
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D015232:Dinoprostone / Q000494:pharmacology; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000494:pharmacology*; D008297:Male; D008638:Mesenteric Arteries / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018836:Inflammation Mediators; D015740:Calcitonin Gene-Related Peptide; D015232:Dinoprostone; D001920:Bradykinin