title: Allogeneic bone marrow transplantation for leukemia.
abstract: Allogeneic bone marrow transplantation cures some persons with acute lymphoblastic leukemia, acute myeloblastic leukemia, and chronic myelogenous leukemia. Considerable data suggest that most cures result from immune-mediated antileukemia effects of the transplant rather than intensive pretransplantation chemotherapy and radiation. The mechanism of these immune-mediated effects, termed graft-versus-leukemia, is unknown. In the past 25 years more than 20,000 allogeneic transplantations were performed worldwide in persons with leukemia. Here we review single- and multicenter studies and analyses of the International Bone Marrow Transplant Registry on results of allografts for leukemia.
authors.affiliation: University of Parma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Butturini
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002986:Clinical Trials as Topic; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000276:immunology / Q000628:therapy*; D015337:Multicenter Studies as Topic; D017063:Outcome Assessment, Health Care
chemical_list: D000970:Antineoplastic Agents