title: Early changes in circulating blood volume and volume regulating humoral factors after implantation of an electrohydraulic total artificial heart.
abstract: The early changes in circulating blood volume (CBV) and volume regulating humoral factors after implantation of an electrohydraulic total artificial heart (EH-TAH) were investigated in a calf and compared with results in a sham operated control calf. CBV was measured by the dye dilution method using indocyanine green. CBV and humoral factors were periodically investigated. In the EH-TAH implanted calf, the cardiac output was estimated at 6-7 L/ min (94-109 ml/kg/min), and the aortic pressure and aerobic metabolic condition were favorable. Nevertheless, the CBV was increased to 132 and 168% of the pre-operative value (range in the control calf, 83-103%) on post operative days 4 and 8, respectively. The atrial natriuretic peptide level on days 2, 5, and 7 was 23, 170, and 240 (in the control calf, 19-61) pg/ml, respectively, and the antidiuretic hormone level was 7.3, 2.0, and 1.3 (0.5-1.3) pg/ ml, respectively. The plasma renin activity was 3.2, 3.7, and 3.1 (0.5-0.3) ng/ml/hr, respectively. The angiotensin-I and angiotensin-II levels were also increased in the EH-TAH implanted calf. It is concluded that significant water retention occurs even at sufficient cardiac output early after EH-TAH implantation. The changes in humoral factors are suggested to arise secondary to the increased CBV or other unknown factors.
authors.affiliation: Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: T
authors.initials: T
authors.lastname: Masuzawa
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: T
authors.initials: T
authors.lastname: Nakatani
authors.forename: Y
authors.initials: Y
authors.lastname: Sohn
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Takiura
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: Y
authors.initials: Y
authors.lastname: Takewa
authors.forename: Y
authors.initials: Y
authors.lastname: Wakisaka
authors.forename: H
authors.initials: H
authors.lastname: Takano
mesh_terms: D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D001810:Blood Volume / Q000502:physiology*; D002302:Cardiac Output; D002417:Cattle; D006354:Heart, Artificial / Q000009:adverse effects*; D006439:Hemodynamics; D011474:Prosthesis Design; D012083:Renin / Q000097:blood; D014667:Vasopressins / Q000097:blood
chemical_list: D014667:Vasopressins; D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D000803:Angiotensin I; D012083:Renin