The enhancer shift: a model to explain the developmental control of IgH gene expression in B-lineage cells.
The roles attributed to the E mu enhancer and the downstream 3' regions acting as locus control regions (LCRs) have allowed comparisons to be drawn between regulation of the IgH locus in early and late B-cell development and other systems governed by LCR activity. Here, the importance of the IgH 3'LCR and its putative functional role in the control of IgH gene expression is evaluated and compared with the 5'LCR regulatory region of the human beta-globin locus.
Arulampalam
V
V
Dept of Biosciences, Karolinska Institute, Huddinge, Sweden. Sven.Pettersson@cbt.ki.se
Eckhardt
L
L
Pettersson
S
S
D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008957:Models, Genetic; D011401:Promoter Regions, Genetic
D007143:Immunoglobulin Heavy Chains