title: Membrane formation and cellular response on the surface of lenses implanted in rabbit eyes.
abstract: OBJECTIVE
  To study the pathogenesis of membrane formation and cellular response on the surface of posterior chamber intraocular lenses (IOLs) implanted in rabbits.
  
  
  METHODS
  Department of Histology and Embryology, Pathology, Ophthalmology. The First Military Medical University, Guangzhou, P.R. China.
  
  
  METHODS
  Thirty rabbits had extracapsular lens extraction and posterior chamber IOL implantation. The IOLs were removed 4, 7, 15, 30, and 90 days postoperatively. Membrane formation and cellular response on IOL surfaces were evaluated using light (n = 25), transmission (n = 5), and scanning electron (n = 5) microscopy.
  
  
  RESULTS
  On 30 IOLs, the incidence of cellular adhesion was 100%. Cellular components comprised macrophages, fibroblast-like cells, epithelioid cells, giant cells, ultralarge giant cells, and lymphocytes. A thin, proteinaceous film was also seen on the surface of the IOLs. The membrane of the IOL surface comprised fibrin, collagen fibrils, macrophages, fibroblast-like cells, giant cells, and fibroblasts.
  
  
  CONCLUSIONS
  The findings of this study might apply to humans because cellular elements and membranes have been reported in humans.
authors.affiliation: Department of Ophthalmology, Nanfang Hospital, First Military Medical University, Guangzhou, P.R. China.
authors.forename: F Y
authors.initials: FY
authors.lastname: Yang
authors.forename: S Z
authors.initials: SZ
authors.lastname: Li
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Liu
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure; D015726:Giant Cells / Q000378:metabolism* / Q000648:ultrastructure; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008214:Lymphocytes / Q000378:metabolism* / Q000648:ultrastructure; D008264:Macrophages / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008566:Membranes / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011817:Rabbits