title: IgM, IgG and IgA class enterobacterial antibodies in serum and synovial fluid in patients with ankylosing spondylitis and rheumatoid arthritis.
abstract: IgM, IgG and IgA class antibodies against three Klebsiella pneumoniae capsular types, Escherichia coli and Proteus mirabilis, as well as total immunoglobulin concentrations, were measured by enzyme immunoassay and radial immunodiffusion technique, respectively, in paired serum and synovial fluid samples from eight patients with ankylosing spondylitis and 10 with rheumatoid arthritis. No clear evidence for intra-articular antibody production against any of the studied microbes was found.
authors.affiliation: National Public Health Institute, Turku, Finland.
authors.forename: O
authors.initials: O
authors.lastname: Mäki-Ikola
authors.forename: M
authors.initials: M
authors.lastname: Penttinen
authors.forename: R
authors.initials: R
authors.lastname: Von Essen
authors.forename: C
authors.initials: C
authors.lastname: Gripenberg-Lerche
authors.forename: H
authors.initials: H
authors.lastname: Isomäki
authors.forename: K
authors.initials: K
authors.lastname: Granfors
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis* / Q000096:biosynthesis / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D004755:Enterobacteriaceae / Q000276:immunology*; D004756:Enterobacteriaceae Infections / Q000097:blood / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis / Q000096:biosynthesis / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis / Q000097:blood; D007075:Immunoglobulin M / Q000032:analysis / Q000096:biosynthesis / Q000097:blood; D007136:Immunoglobulins / Q000032:analysis* / Q000096:biosynthesis / Q000097:blood; D007711:Klebsiella pneumoniae / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011513:Proteus mirabilis / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000276:immunology*; D013582:Synovial Fluid / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins