Acute promyelocytic leukemia in a HIV seropositive patient.
Acute myeloid leukemia (AML) is infrequent in patients with human immunodeficiency virus (HIV) infection. Among AML, acute promyelocytic leukemia (APL) has been rarely described in such patients, with only one case being published. We report a 30 years-old intravenous drug abuser HIV-infected male with APL who attained complete clinical, morphological, and molecular remission after differentiation therapy with all-trans-retinoic acid (ATRA) followed by intensive chemotherapy. The results of treatment in this patient and in other AML published cases suggest that therapy for AML should not be modified because of HIV infection if patients have an adequate performance status.
Calvo
R
R
Hematology Department, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma of Barcelona, Spain.
Ribera
J M
JM
Battle
M
M
Sancho
J M
JM
Granada
I
I
Flores
A
A
Millá
F
F
Feliu
E
E
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000097:blood / Q000150:complications; D006679:HIV Seropositivity / Q000097:blood / Q000150:complications*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000188:drug therapy* / Q000821:virology*; D008297:Male; D019966:Substance-Related Disorders; D014212:Tretinoin / Q000627:therapeutic use
D000970:Antineoplastic Agents; D014212:Tretinoin