title: [Preparation of galactosyl-cytochrome C and studies on its hepatic targeting property].
abstract: This paper reports the preparation of the coupling compound between thiogalactose and cytochrome C(Cyt-C). The binding tests of this compound to asialoglycoprotein receptor have also been carried out in vivo. The results show that the pharmacokinetics of this compound is in accordance with the basic characteristic of receptor induced binding. The highest uptake of liver reaches to 32.9% and at the same time the conjugate remains 78.6% the biological activity of Cyt-C. It is possibly a hepatic targeting drug or a hepatic targeting carrier.
authors.affiliation: School of Pharmacy, Chengdu.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhong
authors.forename: Y
authors.initials: Y
authors.lastname: Zou
authors.forename: C
authors.initials: C
authors.lastname: Guan
authors.forename: C
authors.initials: C
authors.lastname: Jin
mesh_terms: D000818:Animals; D037263:Asialoglycoprotein Receptor; D001212:Asialoglycoproteins / Q000378:metabolism; D002645:Chickens; D003574:Cytochrome c Group / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D045304:Cytochromes c; D004337:Drug Carriers; D005697:Galactosides / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D037263:Asialoglycoprotein Receptor; D001212:Asialoglycoproteins; D003574:Cytochrome c Group; D004337:Drug Carriers; D005697:Galactosides; D011956:Receptors, Cell Surface; C109564:galactosyl-cytochrome C; D045304:Cytochromes c