Efficacy of CDDP and AGM-1470 chemotherapy against lung metastasis in rat osteosarcoma depends on the timing of combined administration.
The efficacy of combination therapy with cis-diammine-dichloroplatinum (II) (CDDP) and o-(chloroacetyl-carbamoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line, previously established in our laboratory, with a high potential for metastasis. Tumor-bearing male Fischer 344 rats were administered CDDP (2.5 mg/kg) together with, or after discontinuation of, AGM-1470 treatment (10 mg/kg/body weight/week). When CDDP was administered three days after discontinuation of AGM-1470 the most pronounced antimetastatic effects were observed, although the antitumor effect was approximately the same.
Morishita
T
T
Department of Orthopedic Surgery, Nara Medical University, Japan.
Mii
Y
Y
Miyauchi
Y
Y
Miura
S
S
Honoki
K
K
Aoki
M
M
Kido
A
A
Tamai
S
S
Tsutsumi
M
M
Konishi
Y
Y
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage*; D003510:Cyclohexanes; D062109:Dermatologic Surgical Procedures; D004334:Drug Administration Schedule; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008175:Lung Neoplasms / Q000098:blood supply / Q000517:prevention & control / Q000556:secondary*; D008297:Male; D009368:Neoplasm Transplantation; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D012516:Osteosarcoma / Q000098:blood supply / Q000188:drug therapy / Q000517:prevention & control / Q000556:secondary*; D051381:Rats; D011916:Rats, Inbred F344; D012074:Remission Induction; D012717:Sesquiterpenes / Q000008:administration & dosage*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D003510:Cyclohexanes; D012717:Sesquiterpenes; D002945:Cisplatin; D000077609:O-(Chloroacetylcarbamoyl)fumagillol