Antimycobacterial activity of some 2,3-dianilinoquinoxaline derivatives.
The antimycobacterial activity of 2,3-dianilinoquinoxaline derivatives was studied and the substances were found to be mostly wide-spectrum antimycobacterial agents. Replacement of one nitrogen atom in the heterocycle for oxygen or sulfur was usually accompanied by loss of activity. The model structure for the study was the wide-spectrum antimycobacterial drug clofazimine.
Waisser
K
K
Department of Inorganic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.
Beckert
R
R
Slosáfrek
M
M
Janota
J
J
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002991:Clofazimine / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011810:Quinoxalines; D002991:Clofazimine