title: [An autopsy case of severe tuberculosis associated with anal fistula and intestinal perforation].
abstract: A 55 year-old man was admitted to the department of the gastroenterology of the hospital because of severe weakness and appetite loss for the past one month. In the last two months, he has been suffering from recurrent fistula of the anus. He left his symptoms without therapy. A gastric ulcer was found out with gastric endoscopy. At the same time, chest X-ray film showed bilateral abnormal shadows, which were suspected of severe pulmonary tuberculosis by a chest physician. After the admission, the patient immediately developed respiratory failure. Both sputa and discharge from anal fistula were positive for acid fast bacillus. Despite of anti-tuberculosis therapy and mechanical ventilation, he died of respiratory failure. At the autopsy, severe pulmonary tuberculosis, tuberculous fistula of the anus, intestinal tuberculosis with perforation, miliary tuberculosis and peptic ulcer of the stomach were defined. We suspected that the extensive disease caused by hematogeneous spread and the late diagnosis of tuberculosis was owing to patient's delay.
authors.affiliation: Department of the Respiratory Medicine, Showa General Hospital, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Iwase
authors.forename: S
authors.initials: S
authors.lastname: Shiota
authors.forename: Y
authors.initials: Y
authors.lastname: Nakaya
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: S
authors.initials: S
authors.lastname: Aoki
authors.forename: R
authors.initials: R
authors.lastname: Matsuoka
authors.forename: T
authors.initials: T
authors.lastname: Nagayama
mesh_terms: D017809:Fatal Outcome; D006801:Humans; D007077:Ileal Diseases / Q000473:pathology*; D007416:Intestinal Perforation / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012003:Rectal Fistula / Q000473:pathology*; D014385:Tuberculosis, Gastrointestinal / Q000473:pathology*; D014397:Tuberculosis, Pulmonary / Q000473:pathology*