title: Chemical kindling induced by pentylenetetrazol changes cholecystokinin mRNA and peptide levels in rat frontal cortex.
abstract: Kindling model is useful to study the mechanism of learning and memory. Cholecystokinin (CCK) mRNA and CCK-like immunoreactivity (CCK-LI) levels in the hippocampus and frontal cortex of chemically kindled rats were determined at different time points. In the frontal cortex, chronic treatment with pentylenetetrazol (PTZ) (40 mg/kg per day for 8 days) increased CCK mRNA level at 7 days, and decreased CCK-LI level at 2 and 7 days after the last injection. However, neither CCK mRNA nor CCK-LI levels in the hippocampus changed. These results suggest that PTZ-induced kindling increases CCK mRNA expression and CCK-LI release in the frontal cortex.
authors.affiliation: Research and Development Department, Dainabot Co. Ltd., Chiba, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: T
authors.initials: T
authors.lastname: Chikuma
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Kato
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000235:genetics*; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009479:Neuropeptides / Q000378:metabolism*; D010433:Pentylenetetrazole; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009479:Neuropeptides; D012333:RNA, Messenger; D002766:Cholecystokinin; D010433:Pentylenetetrazole