title: Hemodynamic and humoral conditions in stepwise reduction of pulmonary blood flow during venoarterial bypass in awake goats.
abstract: The effects of reduced pulmonary arterial blood flow (PAF) during venoarterial bypass (VAB) on hemodynamic and humoral conditions were investigated in a series of experiments in a chronic animal model. A biventricular bypass system was installed in five adult goats weighing 49.8 +/- 1.1 kg. Two weeks later, the extracorporeal circuitry was changed to VAB without anesthesia. The PAF was reduced stepwise from 100% to 50, 25, 10, and 0% of total systemic flow. The mean aortic pressure and systemic vascular resistance decreased from 110 +/- 14 to 66 +/- 3 mmHg and from 1,288 +/- 77 to 740 +/- 73 dyne.sec/cm5, respectively, in proportion to the decrease in PAF from 100 to 0%. The prostaglandin E2 concentration increased from 1.5 +/- 0.6 to 8.8 +/- 0.6 pg/ml following the decrease in PAF from 100 to 0%. The renin-angiotensin system increased in proportion to the decrease in PAF. In contrast, the epinephrine and norepinephrine concentrations (60 +/- 10 and 227 +/- 80 pg/ml, respectively, at 100% PAF) did not change appreciably even at 10% PAF, but were markedly elevated to 335 +/- 117 and 2,088 +/- 1,503 pg/ml at 0% PAF. The antidiuretic hormone level similarly changed. In conclusion, decrease in PAF during VAB exerts significant effects on hemodynamics in a proportional manner and on vasoactive humoral factors in a diverse manner.
authors.affiliation: Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takewa
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: K
authors.initials: K
authors.lastname: Eya
authors.forename: T
authors.initials: T
authors.lastname: Nakatani
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: Y S
authors.initials: YS
authors.lastname: Sohn
authors.forename: T
authors.initials: T
authors.lastname: Masuzawa
authors.forename: Y
authors.initials: Y
authors.lastname: Wakisaka
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: H
authors.initials: H
authors.lastname: Takano
authors.forename: S
authors.initials: S
authors.lastname: Kitamura
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002395:Catecholamines / Q000097:blood; D005112:Extracorporeal Circulation / Q000009:adverse effects; D006041:Goats; D006439:Hemodynamics; D008955:Models, Cardiovascular; D010100:Oxygen / Q000097:blood; D011453:Prostaglandins / Q000097:blood; D011652:Pulmonary Circulation / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology
chemical_list: D002395:Catecholamines; D011453:Prostaglandins; D002245:Carbon Dioxide; D010100:Oxygen