title: Estimating the daily dialysate drain volume required in CAPD for a target peritoneal creatinine clearance by body water and peritoneal transport characteristics.
abstract: Stepwise logistic regression performed in 324 clearance studies in 194 patients identified daily drain volume normalized by body water (DV/V) and peritoneal solute transport type as the predictors of peritoneal creatinine clearance (CCrp) in continuous ambulatory peritoneal dialysis (CAPD). Solution of the regression model for DV/V provided DV/V values predicted to provide a desired CCrp at different probabilities. The ability of the predicted DV/V to detect desired CCrp values was tested in a new set of 359 clearance studies in 217 CAPD patients who had a peritoneal equilibration test within 12 months of the clearance study. No patient with low transport had a CCrp exceeding 54 L/1.73 m2 weekly. The following DV/V values detected CCr > or = 54 L/1.73 m2 weekly with a probability of at least 80%: for low-average transport, 0.406 L/L per 24 hours; for high-average transport, 0.339 L/L per 24 hours; for high transport, 0.241 L/L per 24 hours. Corresponding DV/V values for a CCrp of 60 L/1.73 m2 weekly were as follows: for high-average transport, 0.351 L/L per 24 hours; for high transport, 0.271 L/L per 24 hours. For high-average transport, maximal body surface area (BSA) estimates allowing a CCrp of 60 L/1.73 m2 weekly at a CAPD schedule of four daily exchanges with 3-L exchange volume and 1.5 L/24 hour ultrafiltration volume, and with the specified DV/V values were 2.03 m2 in women and 1.77 m2 in men. Corresponding BSA estimates for high peritoneal solute transport were 2.58 m2 in women and 2.21 m2 in men. The delivered dose of CAPD, expressed as DV/V, required to achieve a target CCrp can be calculated from multivariate statistical models taking into account the peritoneal solute transport type. Multiplication of the required DV/V by V provides an estimate of the required daily exchange volume. Maximal BSA estimates allowing a target CCrp can be calculated for each gender and peritoneal solute transport type.
authors.affiliation: Toronto Hospital, Ontario, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Rao
authors.forename: A H
authors.initials: AH
authors.lastname: Tzamaloukas
authors.forename: G H
authors.initials: GH
authors.lastname: Murata
authors.forename: B
authors.initials: B
authors.lastname: Piraino
authors.forename: D
authors.initials: D
authors.lastname: Malhotra
authors.forename: J
authors.initials: J
authors.lastname: Bernardini
authors.forename: D G
authors.initials: DG
authors.lastname: Oreopoulos
mesh_terms: D001692:Biological Transport; D001830:Body Surface Area; D001834:Body Water / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism*; D015314:Dialysis Solutions; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods; D010537:Peritoneum / Q000378:metabolism*; D014508:Urea / Q000378:metabolism
chemical_list: D015314:Dialysis Solutions; D014508:Urea; D003404:Creatinine