title: [Fast modulation of glutamate and GABA receptor--mediate electrophysiological responses by glucocorticoid].
abstract: Fast modulation by glucocorticoid on gluatmate and GABA receptor-mediated electrophysiological responses was investigated by extracellular iontophoresis and intracellular techniques in rat hypothalamic brain slices and guinea pig coeliac ganglion preparations respectively. The results were as follows: Glucocorticoid inhibited the glutamate receptor-mediated excitatory response and potentiated the GABA receptor-mediated inhibitory response within 5 min after perfusion. All these responses are reversible after removal of the glucocorticoid. Low Ca2+ high Mg2+ medium was ineffective to block the fast modulatory effects of glucocorticoid on the gluatmate and GABA receptor-mediated responses. It appears that the latter responses are mediated through some non-genomic mechanism without an involvement of synaptic circuitry.
authors.affiliation: Department of Physiology, Second Military Medical University, Shanghai.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: B R
authors.initials: BR
authors.lastname: Xing
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Chen
mesh_terms: D000818:Animals; D004594:Electrophysiology; D005728:Ganglia, Sympathetic / Q000502:physiology; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000494:pharmacology*; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018079:Receptors, GABA / Q000187:drug effects* / Q000502:physiology; D017470:Receptors, Glutamate / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents; D018079:Receptors, GABA; D017470:Receptors, Glutamate; D006854:Hydrocortisone