title: Chiral resolution of flobufen by high performance liquid chromatography and capillary electrophoresis.
abstract: The enantiomeric separation of an anti-inflammatory drug flobufen was performed on various chiral columns in liquid chromatography and by reversed phase chromatography and by capillary electrophoresis with beta-cyclodextrin as a chiral selector in the mobile phase and background electrolyte, respectively. The elution order of individual enantiomers is discussed with respect to the absolute chirality of (+/-)-flobufen determined by X-ray crystallography.
authors.affiliation: Department of Analytical Chemistry, Institute of Chemical Technology, Prague, Czech Republic.
authors.forename: E
authors.initials: E
authors.lastname: Tesarvá
authors.forename: M
authors.initials: M
authors.lastname: Gilar
authors.forename: A
authors.initials: A
authors.lastname: Jegorov
authors.forename: M
authors.initials: M
authors.lastname: Uhrová
authors.forename: Z
authors.initials: Z
authors.lastname: Deyl
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification*; D002087:Butyrates / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D018360:Crystallography, X-Ray; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods*; D007202:Indicators and Reagents; D013237:Stereoisomerism; D047392:beta-Cyclodextrins
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002087:Butyrates; D003505:Cyclodextrins; D007202:Indicators and Reagents; D047392:beta-Cyclodextrins; C056474:flobufen; C031215:betadex