The importance of oxidative stress in apoptosis.
In vitro studies have shown that apoptosis can be triggered by many distinct and different stimuli including exposure to physical and chemical agents or by the removal of growth factors. Free radicals and oxidative stress have been implicated in apoptosis, although there is much uncertainty regarding their importance. This review aims to address much of the existing ambiguity.
Clutton
S
S
MRC Radiation and Genome Stability Unit, Harwell, UK.
D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D017382:Reactive Oxygen Species / Q000502:physiology
D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species