Protein conformational distortions induced by membrane interfacial interactions.
It is clear that considerable conformational distortions may occur in peripheral proteins on interaction with anionic lipid bilayers. Specific lipid interactions do occur at least in the case of cytochrome c, and each perturbation and interaction may well take place before insertion into, or translocation across, a biomembrane.
Watts
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Department of Biochemistry, University of Oxford, U.K.
D000818:Animals; D003574:Cytochrome c Group / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
D003574:Cytochrome c Group; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D011506:Proteins; C020888:1,2-dielaidoylphosphatidylethanolamine; C017251:1,2-oleoylphosphatidylcholine