[Effect of angiotensin II on the adrenal glucocorticoids secretion].
The effect of angiotensin II on adrenal cortisol secretion was studied using incubated adrenal tissues of cells preparation of guinea pig and dog. The results showed that: the cortisol secretion in guinea pigs was increased by the addition of angiotensin II in both dose-dependent and time-dependent manner at concentration > or = 10(-9) mol/L (P < 0.01). When ACTH was further added to the angiotensin primed preparation, the output of cortisol was further increased. Deprivation of free calcium largely suppressed the production of cortisol induced by angiotensin II (P < 0.05). These results suggested that angiotensin II exerts a direct effect on the secretion of adrenal cortisol, which required the presence of Ca2+ and is promoted by ACTH.
Yin
Y R
YR
Guangzhou Medical College, PLA.
Yang
G
G
D000311:Adrenal Glands / Q000166:cytology / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology; D002478:Cells, Cultured; D046508:Culture Techniques; D004285:Dogs; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male
D000804:Angiotensin II; D002216:Captopril; D002118:Calcium; D006854:Hydrocortisone