title: [A model of the depressive syndrome in rats induced by the neurotoxin MPTP and autoantibodies to serotonin and dopamine].
abstract: Induction of autoantibodies to serotonin and dopamine in blood serum was demonstrated in a new rat model of experimental depression-like syndrome induced by intraperitoneal injection of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 20 mg/kg daily for 12 days). The level and frequency of detection of antibodies to serotonin within 2 and 3 weeks after MPTP withdrawal did not differ, and the level and frequency of detection of antibodies to dopamine were significantly reduced within 3 weeks as compared with 2 weeks after the MPTP withdrawal. In is suggested that disturbances in neuroimmune interactions play an important part in development of depressive states.
authors.forename: L A
authors.initials: LA
authors.lastname: Vetrilé
authors.forename: N A
authors.initials: NA
authors.lastname: Krupina
authors.forename: L A
authors.initials: LA
authors.lastname: Basharova
authors.forename: G N
authors.initials: GN
authors.lastname: Kryzhanovskiĭ
authors.forename: V A
authors.initials: VA
authors.lastname: Evseev
authors.forename: I N
authors.initials: IN
authors.lastname: Orlova
authors.forename: T E
authors.initials: TE
authors.lastname: Iordanskaia
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000704:Analysis of Variance; D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000187:drug effects*; D003866:Depressive Disorder / Q000139:chemically induced* / Q000276:immunology; D004195:Disease Models, Animal; D004298:Dopamine / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D008297:Male; D009498:Neurotoxins; D051381:Rats; D017208:Rats, Wistar / Q000276:immunology*; D012701:Serotonin / Q000276:immunology*; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D009498:Neurotoxins; D012701:Serotonin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine