[Ecology of influenza viruses in animals and the mechanism of emergence of new pandemic strains].
Ecological studies on influenza viruses revealed that the hemagglutinin genes are introduced into new pandemic strains from viruses circulating in migratory ducks through domestic ducks and pigs in southern China. Experimental infection of pigs with 38 avian influenza virus strains with H1-H13 hemagglutinins showed that at least one strain of each HA subtype replicated in the upper respiratory tract of pigs. Co-infection of pigs with a swine virus and with an avian virus generated reassortant viruses. The results indicate that avian viruses of any subtype can contribute genes in the generation of reassortants. Virological surveillance revealed that influenza viruses in waterfowl reservoir are perpetuated year-by-year in the frozen lake water while ducks are absent.
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Department of Disease Control, Hokkaido University Graduate School of Veterinary Medicine.
D000818:Animals; D001715:Bird Diseases / Q000635:transmission; D001717:Birds; D006734:Horse Diseases / Q000635:transmission; D006736:Horses; D006801:Humans; D007251:Influenza, Human / Q000635:transmission / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000635:transmission; D015047:Zoonoses