title: Basal ganglia damage and impaired visual function in the newborn infant.
abstract: OBJECTIVE
  To examine the effects of early lesions in the visual pathway on visual function; and to identify early prognostic indicators of visual abnormalities.
  
  
  METHODS
  The visual function of 37 infants with perinatal brain lesions on magnetic resonance imaging was assessed using behavioural and electrophysiological variables.
  
  
  RESULTS
  Normal visual behaviour was observed in most infants with large bilateral occipital lesions, but all the infants with associated basal ganglia involvement had abnormal visual function. Visual abnormalities were also present in six infants with isolated basal ganglia lesions.
  
  
  CONCLUSIONS
  These observations suggest that basal ganglia may have an integral role in human visual development and that their presence on neonatal MRI could be an early marker of abnormal visual function.
authors.affiliation: Visual Development Unit, University College London.
authors.forename: E
authors.initials: E
authors.lastname: Mercuri
authors.forename: J
authors.initials: J
authors.lastname: Atkinson
authors.forename: O
authors.initials: O
authors.lastname: Braddick
authors.forename: S
authors.initials: S
authors.lastname: Anker
authors.forename: F
authors.initials: F
authors.lastname: Cowan
authors.forename: M
authors.initials: M
authors.lastname: Rutherford
authors.forename: J
authors.initials: J
authors.lastname: Pennock
authors.forename: L
authors.initials: L
authors.lastname: Dubowitz
mesh_terms: D001479:Basal Ganglia / Q000473:pathology*; D002545:Brain Ischemia / Q000473:pathology* / Q000503:physiopathology; D002675:Child, Preschool; D005074:Evoked Potentials, Visual; D006801:Humans; D002534:Hypoxia, Brain / Q000473:pathology* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D011379:Prognosis; D014786:Vision Disorders / Q000209:etiology*; D014787:Vision Tests; D014793:Visual Cortex / Q000473:pathology