title: Whey deionization method of infant formula affects plasma lipids.
abstract: BACKGROUND
  Casein has proved to be hypercholesterolemic. According to results of previous studies, the casein-to-whey ratio in infant formula influences plasma lipid profile. This study explored whether different methods of whey deionization also affect levels of plasma lipids.
  
  
  METHODS
  Two types of a whey-predominant (whey 60%:casein 40%) formula which differed only in the methods used for whey deionization (ultrafiltration or electrodialysis), were fed to healthy newborn infants for 60 days, using a prospective, double-blind, randomized design. Formulas were otherwise identical in composition.
  
  
  RESULTS
  Groups were similar in gestational age, gender, birth weight, and growth parameters. Evaluation of fasting plasma levels after 60 days revealed significantly higher values of total cholesterol (p < 0.001) and low-density lipoprotein cholesterol (p < 0.001) in infants fed ultrafiltrated whey compared with the same values in infants fed electrodialyzed whey. Plasma levels in the two groups of very low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides revealed no statistically significant differences.
  
  
  CONCLUSIONS
  Plasma lipid profile in infancy is influenced by dietary protein, not only by the casein-to-whey ratio, but also by the method of whey deionization.
authors.affiliation: Pediatric Gastroenterology and Nutrition Unit, Soroka Medical Center, Beer-Sheva, Israel.
authors.forename: Z
authors.initials: Z
authors.lastname: Weizman
authors.forename: C
authors.initials: C
authors.lastname: Ursacha
authors.forename: S
authors.initials: S
authors.lastname: Shany
authors.forename: D
authors.initials: D
authors.lastname: Leader
authors.forename: C
authors.initials: C
authors.lastname: Zegerman
mesh_terms: D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003956:Dialysis; D004311:Double-Blind Method; D004563:Electrochemistry; D005260:Female; D005511:Food Handling / Q000379:methods*; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000009:adverse effects* / Q000032:analysis; D007231:Infant, Newborn; D007477:Ions; D008055:Lipids / Q000097:blood*; D008297:Male; D008894:Milk Proteins / Q000737:chemistry*; D011446:Prospective Studies; D014462:Ultrafiltration; D000067816:Whey Proteins
chemical_list: D008078:Cholesterol, LDL; D007477:Ions; D008055:Lipids; D008894:Milk Proteins; D000067816:Whey Proteins; D002784:Cholesterol