title: dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp.
abstract: Decapentaplegic (Dpp) is a Drosophila member of the Transforming Growth Factor-beta (TGF-beta)/Bone Morphogenetic Protein (BMP) superfamily of growth factors. Dpp serves as a classical morphogen, where concentration gradients of this secreted factor control patterning over many cell dimensions. Regulating the level of Dpp signaling is therefore critical to its function during development. One type of molecule proposed to modulate growth factor signaling at the cell surface are integral membrane proteoglycans. We show here that division abnormally delayed (dally), a Drosophila member of the glypican family of integral membrane proteoglycans is required for normal Dpp signaling during development, affecting cellular responses to this morphogen. Ectopic expression of dally+ can alter the patterning activity of Dpp, suggesting a role for dally+ in modulating Dpp signaling strength. These findings support a role for members of the glypican family in controlling TGF-beta/BMP activity in vivo by affecting signaling at the cell surface.
authors.affiliation: Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Jackson
authors.forename: H
authors.initials: H
authors.lastname: Nakato
authors.forename: M
authors.initials: M
authors.lastname: Sugiura
authors.forename: A
authors.initials: A
authors.lastname: Jannuzi
authors.forename: R
authors.initials: R
authors.lastname: Oakes
authors.forename: V
authors.initials: V
authors.lastname: Kaluza
authors.forename: C
authors.initials: C
authors.lastname: Golden
authors.forename: S B
authors.initials: SB
authors.lastname: Selleck
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D004330:Drosophila / Q000166:cytology / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D019476:Insect Proteins / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics*; D011509:Proteoglycans / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics
chemical_list: D029721:Drosophila Proteins; D019476:Insect Proteins; D008562:Membrane Glycoproteins; D011509:Proteoglycans; D016212:Transforming Growth Factor beta; C098128:dally protein, Drosophila; C064196:dpp protein, Drosophila