title: Penetration of teicoplanin into heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery.
abstract: Penetration of teicoplanin into serum, heart valves, and subcutaneous and muscle tissues was determined in 22 patients undergoing open-heart surgery. Each patient received 12 mg of teicoplanin per kg of body weight as a 30-min intravenous infusion preoperatively. Within 10 h, serum concentrations of teicoplanin declined from 43.1 to 2.8 microg/ml. Teicoplanin concentrations in subcutaneous tissues reached their peak of 9.2 microg/g after 2 to 3 h and decreased slowly to 2.3 microg/g after 9 to 10 h. Concentrations in muscle decreased from 8.7 microg/g to nondetectable levels. Teicoplanin concentrations in cardiac valvular tissue reached their peak of 6.1 microg/g and decreased thereafter to 1.7 microg/g. Teicoplanin concentrations in heart valves were high enough to inhibit methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci, which are known to cause postoperative wound infections and infective endocarditis.
authors.affiliation: Institute for Environmental Medicine and Hospital Epidemiology, University Hospital Freiburg, Germany.
authors.forename: U K
authors.initials: UK
authors.lastname: Frank
authors.forename: E
authors.initials: E
authors.lastname: Schmidt-Eisenlohr
authors.forename: D
authors.initials: D
authors.lastname: Mlangeni
authors.forename: M
authors.initials: M
authors.lastname: Schindler
authors.forename: A
authors.initials: A
authors.lastname: Hoh
authors.forename: F
authors.initials: F
authors.lastname: Beyersdorf
authors.forename: F D
authors.initials: FD
authors.lastname: Daschner
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D005260:Female; D006351:Heart Valves / Q000378:metabolism*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D017334:Teicoplanin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D013903:Thoracic Surgery; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin