The cytosolic phosphoprotein stathmin is expressed in the olfactory system of the adult rat.
Stathmin is a cytosolic protein expressed particularly in the developing nervous system, whose phosphorylation is correlated with the action of multiple extracellular stimuli regulating cell proliferation and differentiation. In this study, we used an antibody that specifically recognizes the carboxyterminal region of stathmin to analyze the distribution of this protein in the olfactory system of adult rats, and found a high and selective immunoreactivity in immature olfactory receptors of the olfactory neuroepithelium and in cells of the rostral migratory stream. These results reveal an expression of stathmin in regions of the adult nervous system characterized by striking structural plasticity and cell renewal, suggesting that this protein could play a role in the differentiation of newly generated cell populations.
Camoletto
P
P
Department of Animal Biology, University of Turin, Italy.
Peretto
P
P
Bonfanti
L
L
Manceau
V
V
Sobel
A
A
Fasolo
A
A
D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D003600:Cytosol / Q000737:chemistry*; D007150:Immunohistochemistry; D008868:Microtubule Proteins; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009830:Olfactory Bulb / Q000737:chemistry; D009831:Olfactory Mucosa / Q000737:chemistry; D009833:Olfactory Pathways / Q000737:chemistry*; D010750:Phosphoproteins / Q000032:analysis*; D016548:Prosencephalon / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D050777:Stathmin
D008868:Microtubule Proteins; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D050777:Stathmin