title: Synthesis and antibacterial activities of new 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octan-2,4-dione moiety.
abstract: The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octane-2,4-dione moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bateria are determined and the effect of substituent on the bicyclic ring as well as stereoisomerism was investigated.
authors.affiliation: Division of Applied Science, Korea Institute of Science and Technology, Seoul, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Nam
authors.forename: C H
authors.initials: CH
authors.lastname: Oh
authors.forename: Y W
authors.initials: YW
authors.lastname: Ham
authors.forename: K S
authors.initials: KS
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Cho
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D015780:Carbapenems