Serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in obese children.
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) metabolism may be disturbed in obese children. We investigated serum GH, IGF-I, IGF-binding protein-3 (IGFBP-3) levels in 42 obese and 40 non-obese healthy children aged 6-14 years. GH stimulation tests with L-dopa and insulin were performed. Serum IGF-I levels were studied by immunoradiometric assay (IRMA) and IGFBP-3 levels by radioimmunoassay (RIA). IGF-I levels were significantly higher in the obese group (p < 0.05), but IGFBP-3 levels were not different from the control group. IGF-I and IGFBP-3 levels were significantly higher in the obese pubertal children than in the obese prepubertal ones (p < 0.05). A positive linear correlation was found between body mass index (BMI) and IGF-I levels (r = 0.51, p < 0.05). These results suggest that obesity may have a considerable effect on IGF-I.
Bideci
A
A
Department of Pediatric Endocrinology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Cinaz
P
P
Hasanoglu
A
A
Elbeg
S
S
D000293:Adolescent; D001827:Body Height; D015992:Body Mass Index; D002648:Child; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D015592:Immunoradiometric Assay; D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007980:Levodopa; D008297:Male; D009765:Obesity / Q000097:blood*; D011863:Radioimmunoassay
D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D007980:Levodopa; D007334:Insulin-Like Growth Factor I