Circulating aggregated platelets, number of platelets per aggregate and platelet size in chronic dialysis patients.
The accelerated arteriosclerosis of chronic dialysis patients is multifactorial. Both non-uremic patients with atherosclerosis and uremic patients have functional platelet abnormalities. Our aim was to study platelet function in chronic dialysis patients and to correlate the findings with the presence of cardiovascular morbidity. Fifty-three chronic dialysis patients were examined. The presence of risk factors for cardiovascular disease (CVD) was recorded, and the patients were examined for the presence of ischemic heart disease, peripheral vascular disease and cerebrovascular accident. The parameters of platelet function, which were examined with the modified Wu and Hoak method, included platelet number, percentage of totally, reversibly and irreversibly aggregated platelets, average number of platelets per aggregate and percentage of large platelets. Significant differences were found between totally aggregated platelets, reversibly and irreversibly aggregated platelets, the percentage of large platelets (p < 0.0001) and the average number of platelets per aggregate (p < 0.001) in dialysis patients compared with control persons. There was no difference between the 2 groups in platelet count. No differences were found between hemodialysis and peritoneal dialysis groups, and the duration of dialysis treatment had no effect. We conclude that platelet abnormalities evident in chronic dialysis patients are a part of the multifactorial etiology of advanced CVD and may predispose dialysis patients to CVD.
Winkler
J
J
Institute of Hypertension and Kidney Diseases, Rabin Medical Center, Petah Tikva, Israel.
Fuchs
J
J
Morduchowicz
G
G
Boner
G
G
Sulkiss
J
J
Weinberger
I
I
D001161:Arteriosclerosis / Q000473:pathology; D001792:Blood Platelets / Q000648:ultrastructure*; D002318:Cardiovascular Diseases / Q000150:complications / Q000401:mortality; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000502:physiology*; D010976:Platelet Count; D010979:Platelet Function Tests; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors