title: Salmonella infection increases porcine antibacterial peptide concentrations in serum.
abstract: PR-39 is a multifunctional neutrophil peptide involved in host defense and inflammation. To investigate the involvement of PR-39 in a Salmonella choleraesuis infection, a PR-39 enzyme immunoassay was developed. The concentrations of PR-39 in serum were 13.6 +/- 1.9 ng/ml before challenge and increased (P < 0.01) threefold by 10 to 14 days postinfection. Peripheral blood neutrophil counts paralleled the changes in the concentrations of PR-39 in serum, both returned to basal values by 4 weeks postinfection. These findings suggest that the concentrations of serum PR-39 reflect the involvement of this antibacterial peptide in the host's response to an S. choleraesuis infection.
authors.affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USA.
authors.forename: G
authors.initials: G
authors.lastname: Zhang
authors.forename: C R
authors.initials: CR
authors.lastname: Ross
authors.forename: S S
authors.initials: SS
authors.lastname: Dritz
authors.forename: J C
authors.initials: JC
authors.lastname: Nietfeld
authors.forename: F
authors.initials: F
authors.lastname: Blecha
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood*; D023181:Antimicrobial Cationic Peptides; D001770:Blood Bactericidal Activity; D004797:Enzyme-Linked Immunosorbent Assay; D006041:Goats; D051379:Mice; D008807:Mice, Inbred BALB C; D018375:Neutrophil Activation / Q000187:drug effects / Q000502:physiology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010455:Peptides / Q000097:blood*; D012481:Salmonella Infections, Animal / Q000097:blood* / Q000276:immunology; D013268:Stimulation, Chemical; D013552:Swine; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; C072212:PR 39; D013755:Tetradecanoylphorbol Acetate