The effect of cyclosporine A and amlodipine on the activity of gamma-glutamyl transpeptidase in mouse cerebral cortex.
The effect of cyclosporine A (CsA) and dihydropyridine calcium channel blocker (CCB) amlodipine on gamma-glutamyl transpeptidase (GGT; EC 2.3.2.2) activity in mouse cerebral cortex was investigated. Mice received amlodipine (0.07 mg kg-1), CsA (10, 20 and 40 mg kg-1) and CsA in the above doses combined with amlodipine (0.07 mg kg-1) once daily, intraperitoneally for 5 days. The control group received saline. Amlodipine decreased GGT activity when compared to the control group. GGT activity in the cerebral cortex was decreased after treatment with CsA (20 and 40 mg kg-1), but was not changed after treatment with CsA in the 10 mg kg-1 dose as compared to the control group. CsA in doses of 20 and 40 mg kg-1, combined with amlodipine, increased GGT activity as compared to the control group groups received the same doses of CsA without amlodipine and received only amlodipine. However, CsA in the 10 mg kg-1 dose combined with amlodipine decreased GGT activity when compared to the control group, but did not show any statistical difference when compared to the groups treated only with amlodipine or CsA in the same doses. These results suggest that CsA and amlodipine may modulate GGT activity in mouse cerebral cortex.
Maj
J G
JG
Department of Clinical Biochemistry and Environmental Toxicology, School of Medicine, Lublin, Poland.
Tomaszewski
J J
JJ
D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000201:enzymology*; D016572:Cyclosporine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D005723:gamma-Glutamyltransferase / Q000187:drug effects* / Q000378:metabolism*
D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D017311:Amlodipine; D016572:Cyclosporine; D005723:gamma-Glutamyltransferase