title: Follicular dendritic cell tumor with histiocytic characteristics and fibroblastic antigen.
abstract: A report is presented of a follicular dendritic cell (FDC) tumor arising in the lymph nodes and inguen of a 55-year-old Japanese female, who had suffered from schizophrenia for 25 years. The left submandibular lymph nodes had completely lost their normal architecture, except for the capsule, due to tumor cell infiltration. Occasional nodular structures resembling epithelioid granulomas, attributable, at least in part, to follicular involvement of tumor cells, were observed. These nodules were composed of epithelioid- or fibroblast-like tumor cells forming interwoven fascicles, to which small lymphocytes were attached. Tumor cells were also scattered in the internodular areas. For more atypical tumor cells, arranged in a sheet-like structure, were present in the inguinal specimen, the tumor cells of which expressed Ki-M4p, CD21, CD35 and other antigens known to be expressed on FDC. Furthermore, they also expressed the monocyte/macrophage antigens, alpha 1-antitrypsin, alpha 1-antichymotrypsin, lysozyme, CD14, CD33, CD68 and Mac387 and fibroblastic antigen. Ultrastructural studies demonstrated lysosomal granules as well as a few desmosomes, indicating the tumor cells possessed fibrohistiocytic and FDC characteristics.
authors.affiliation: Department of Laboratory Medicine, University of Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Masunaga
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Katata
authors.forename: T
authors.initials: T
authors.lastname: Furubayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Kanayama
authors.forename: A
authors.initials: A
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Shiroko
authors.forename: S
authors.initials: S
authors.lastname: Itoyama
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D003713:Dendritic Cells / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000276:immunology*; D006644:Histiocytes / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology* / Q000648:ultrastructure; D008207:Lymphatic Metastasis / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications
chemical_list: D015415:Biomarkers