Site-specific recombination: synapsis and strand exchange revealed.
Recently determined crystal structures of several members of the lambda integrase family of site-specific recominases have provided insights into the cis versus trans action of active site constituents, and hte processes of synapsis and strand exchange.
Grindley
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ND
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8114, USA.
D001665:Binding Sites; D004254:DNA Nucleotidyltransferases / Q000737:chemistry / Q000378:metabolism*; D019426:Integrases / Q000737:chemistry / Q000378:metabolism*; D045522:Recombinases; D011995:Recombination, Genetic; D013329:Structure-Activity Relationship
D045522:Recombinases; D004254:DNA Nucleotidyltransferases; D019426:Integrases; C115006:integron integrase IntI1