Chemoattractant receptors.
One of the first responses in the inflammatory process is the migration of cells along gradients of specific chemical signals, the chemotactic factors. Chemotactic factors are referred to as ligands that bind to structurally specific cell surface receptors. Binding of the ligand to its receptor initiates a series of coordinated events leading to cell migration, adhesion, and activation. This review describes recent advances in structure-function relationships of chemotactic factor receptors on human leukocytes as well as potential areas for pharmacological intervention.
Perez
H D
HD
Berlex Biosciences, Richmond, California, USA.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002630:Chemotactic Factors / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D011971:Receptors, Immunologic / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
D002630:Chemotactic Factors; D011971:Receptors, Immunologic; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases