title: Single-lung transplantation in a patient with cystic fibrosis and an asymmetric thorax.
abstract: We report metachronous single-lung transplantation for cystic fibrosis after contralateral pneumonectomy. Kyphoscoliosis and mediastinal shift required careful donor-lung sizing with computed tomography and was not dependent on typical parameters. Severe reperfusion injury was treated with nitric oxide, C1-esterase inhibitor, and continuous venovenous hemodialysis. The patient was extubated on the fifth postoperative day and is alive and well. We conclude that single-lung transplantation after contralateral pneumonectomy for patients with cystic fibrosis and an asymmetric chest and evident lung volume mismatch may be an acceptable functional therapeutic option.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Essen University Medical School, Germany.
authors.forename: J A
authors.initials: JA
authors.lastname: Piotrowski
authors.forename: F H
authors.initials: FH
authors.lastname: Splittgerber
authors.forename: T J
authors.initials: TJ
authors.lastname: Donovan
authors.forename: F
authors.initials: F
authors.lastname: Ratjen
authors.forename: H R
authors.initials: HR
authors.lastname: Zerkowski
mesh_terms: D002648:Child; D003550:Cystic Fibrosis / Q000150:complications / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007738:Kyphosis / Q000150:complications; D016040:Lung Transplantation; D008297:Male; D011013:Pneumonectomy; D015427:Reperfusion Injury / Q000628:therapy; D012600:Scoliosis / Q000150:complications; D013909:Thorax / Q000473:pathology*