Iodised rapeseed oil for eradication of severe endemic goitre.
Iodised oil is traditionally based on the fatty acids (FAs) of the poppyseed, an expensive commodity. An equipotent but cheaper vehicle would be welcome. Iodination of rapeseed oil yields a product (Brassiodol) with a total iodine content of 376 mg/mL. Brassiodol has been compared with the poppyseed-based Lipiodol in two villages in Chad in the west African goitre belt. A 2 mL dose of Brassiodol is followed by urinary spillover of half the ingested iodine. The other half undergoes tissue sequestration and slow release, allowing protection against iodine deficiency for 9 months and regression of stage I/II goitre for longer than was achieved with Lipiodol. The prolonged protection offered by Brassiodol can be attributed to its unique lipid profile. The urinary output argues that 1 mL should not be exceeded, and at that dose the cost would be only 20 US cents per person per year.
Ingenbleek
Y
Y
Laboratory, Faculty of Pharmacy, University Louis Pasteur, Strasbourg, France.
Jung
L
L
Férard
G
G
Bordet
F
F
Goncalves
A M
AM
Dechoux
L
L
D000328:Adult; D001937:Brassica; D002596:Chad; D005227:Fatty Acids / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated; D005260:Female; D006043:Goiter, Endemic / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007455:Iodine / Q000172:deficiency / Q000652:urine; D007459:Iodized Oil / Q000627:therapeutic use*; D008297:Male; D010938:Plant Oils / Q000378:metabolism / Q000627:therapeutic use*; D000074262:Rapeseed Oil; D013963:Thyroid Hormones / Q000097:blood
D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil; D013963:Thyroid Hormones; C109370:brassiodol; D007459:Iodized Oil; D007455:Iodine