Competitive inhibition of swine kidney copper amine oxidase by drugs: amiloride, clonidine, and gabexate mesylate.
Competitive inhibition of swine kidney copper amine oxidase by diuretic, antihypertensive, and anticoagulant drugs, amiloride, clonidine, and gabexate mesylate, respectively, is reported. The affinity of these compounds for swine kidney copper amine oxidase is similar to that observed for inhibitor binding to nitric oxide synthase and trypsin-like serine proteinases. This finding suggests that amiloride, clonidine, and gabexate mesylate should be administrated under careful control, since enzyme cross-inhibition may occur also in vivo.
Federico
R
R
Department of Biology, Third University of Rome, Italy.
Angelini
R
R
Ercolini
L
L
Venturini
G
G
Mattevi
A
A
Ascenzi
P
P
D000376:Agmatine / Q000378:metabolism; D000584:Amiloride / Q000378:metabolism / Q000494:pharmacology*; D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D002384:Catalysis; D003000:Clonidine / Q000378:metabolism / Q000494:pharmacology*; D016670:Gabexate / Q000378:metabolism / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D010084:Oxidation-Reduction; D011700:Putrescine / Q000378:metabolism; D013552:Swine
D016670:Gabexate; D000376:Agmatine; D000584:Amiloride; D006631:Amine Oxidase (Copper-Containing); D003000:Clonidine; D011700:Putrescine