Induction of superoxide dismutase and catalase activity in different rat tissues and protection from UVB irradiation after topical application of Ginkgo biloba extracts.
Ginkgo biloba extract (GBE) prepared from the leaves of Ginkgo biloba with 50% diluted alcohol was found to locally induce superoxide dismutase (SOD) and catalase (CAT) enzyme activity in epidermis after topical application, and also to systemically increase the activity of both enzymes in the liver, heart and kidney of Sprague Dawley rats. Skin pretreated with 50% diluted alcohol-extracted liquid formulation was protected from exacerbation of UVB damage. Changes in the lipid structure of the skin of rats determined by ATR/FT-IR spectroscopy demonstrated penetration of active components from GBE dosage formulations.
Lin
S Y
SY
Department of Medical Research and Education, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Chang
H P
HP
D000287:Administration, Topical; D000818:Animals; D002374:Catalase / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects*; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology*; D020441:Ginkgo biloba; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects; D013482:Superoxide Dismutase / Q000378:metabolism*; D014466:Ultraviolet Rays / Q000009:adverse effects; D000096983:Ginkgo Extract
D002374:Catalase; D016166:Free Radical Scavengers; D010936:Plant Extracts; D013482:Superoxide Dismutase; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract