title: Influence of maternal infections with viral agents or Toxoplasma gondii during pregnancy on fetal IgE production.
abstract: The importance of maternal infections with Toxoplasma gondii, cytomegalovirus (CMV), Parvovirus B19, respiratory syncytial virus (RSV), and influenza A and B on fetal IgE synthesis was studied in 153 pregnant women. No case of specific IgM activity or viral DNA in cord blood, indicating a congenital infection, was found. From gestational week 15 to delivery, maternal IgG-Ab seroconversion to Parvovirus B19, RSV, influenza A, or influenza B occurred in 47 women. At delivery, serologic signs of past infection with T. gondii were observed in 29 (19%) women, and the corresponding figure for CMV was 117 (77%). The number of women with positive IgG seroconversion during pregnancy or positive IgG-Ab activity toward the studied infectious agents at delivery did not differ significantly among infants with an increased (> or = 1.3 kU/l; n = 51) or with an undetectable (< 0.1 kU/l; n = 102) cord-blood IgE level. These results show that genetic and other environmental factors probably have a greater influence on fetal IgE synthesis than do maternal infections during pregnancy.
authors.affiliation: Sach's Children's Hospital, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Lilja
authors.forename: M
authors.initials: M
authors.lastname: Forsgren
authors.forename: S G
authors.initials: SG
authors.lastname: Johansson
authors.forename: E
authors.initials: E
authors.lastname: Kusoffsky
authors.forename: H
authors.initials: H
authors.lastname: Oman
mesh_terms: D000293:Adolescent; D000328:Adult; D000913:Antibodies, Protozoan / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D003586:Cytomegalovirus Infections / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis / Q000302:isolation & purification; D005260:Female; D005312:Fetal Blood / Q000276:immunology / Q000821:virology; D005333:Fetus / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications; D007073:Immunoglobulin E / Q000378:metabolism*; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis; D007231:Infant, Newborn; D009980:Influenza A virus / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000276:immunology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000276:immunology*; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology; D014123:Toxoplasmosis / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E