CD3-CD4+ cells with a Th2-like pattern of cytokine production in the peripheral blood of a patient with cutaneous T cell lymphoma.
A case of cutaneous T cell lymphoma associated with mild eosinophilia and rise of IgE levels is reported. A population of CD3-CD4+ cells was observed in the peripheral blood. After activation, these purified CD3-CD4+ cells showed a Th2 pattern of cytokine production, secreting higher levels of IL-5 and IL-4 and lower levels of IFN-gamma compared to the patient's and controls' CD3+CD4+ cells. Moreover, high levels of IL-5 and soluble CD30, a marker of Th2 cell activation, were detected in the patient's serum.
Brugnoni
D
D
Servizio di Immunologia Clinica, Spedali Civili, Brescia, Italy.
Airò
P
P
Tosoni
C
C
Taglietti
M
M
Lodi-Rizzini
F
F
Calzavara-Pinton
P
P
Leali
C
C
Cattaneo
R
R
D014408:Biomarkers, Tumor / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D016410:Lymphoma, T-Cell, Cutaneous / Q000097:blood*; D008875:Middle Aged; D018418:Th2 Cells
D014408:Biomarkers, Tumor; D016207:Cytokines; D007376:Interleukin-2; D015848:Interleukin-5; D015847:Interleukin-4; D007371:Interferon-gamma