[The effect of acute and chronic cadmium and gamma radiation exposures on micronucleus formation in mouse bone marrow cells].
It was shown using micronucleus test that Cd chloride in drinking water (5 mg Cd2+/1, 32 days) does not induce cytogenetic damages in mouse bone marrow cells and does not affect the yield of micronuclei (MN) after chronic gamma-irradiation (1 Gy), whereas Cd chloride injection (1 mg Cd2+/kg body wt) leads to an increase in the number of MN. At the same time, both acute and chronic Cd2+ treatment decrease the number of MN induced by acute irradiation. The protective effect of Cd2+ is supposed to be due to activation of repair processes or metallothionein induction.
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D000222:Adaptation, Physiological / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects* / Q000648:ultrastructure; D019256:Cadmium Chloride / Q000633:toxicity*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D048629:Micronuclei, Chromosome-Defective / Q000000981:diagnostic imaging* / Q000187:drug effects*; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D011859:Radiography; D013997:Time Factors
D009153:Mutagens; D019256:Cadmium Chloride