[Effect of late revascularization of the responsible artery after infarction on left ventricular function and remodeling].
The effects of late angioplasty of the culprit artery after myocardial infarction on the decisive prognostic factors of left ventricular function and remodeling are not well known. When the culprit artery is narrowed but patent, angioplasty leads to improvement in segmental contractility and global left ventricular function: it does not seem to influence left ventricular end-diastolic volume. When the artery remains occluded, global and regional left ventricular function is also improved when the recanalised artery remains patent. Moreover, restoration of satisfactory artery patency prevents ventricular remodeling whereas in failed angioplasty or reocclusion, there is a progressive increase in left ventricular volume. However, these results observed in unselected patients could be improved: it would seem that the different beneficial effects only occur when there is residual myocardial viability; in the absence of signs of myocardial viability, the ventricular effects of limitations of angioplasty (incidence of restenosis or reocclusion in this specific context, lower primary success rate in complete arterial occlusion) explain the negativity of rare randomised studies comparing the outcome of left ventricular function depending on whether a conventional attitude or systematic revascularisation of the culprit artery is adopted.
Danchin
N
N
Service de cardiologie, CHU Nancy-Brabois.
Angioi
M
M
Marie
P Y
PY
Grentzinger
A
A
Karcher
G
G
Juillière
Y
Y
Bertrand
A
A
Cherrier
F
F
D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D006439:Hemodynamics; D006801:Humans; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000150:complications* / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome; D016277:Ventricular Function, Left