Myocardial ventricular mass related to coronary artery distribution in human hearts.
This prospective study of 120 autopsy collected human hearts correlates the "Right Ventricle/Left Ventricle" free walls mass ratio and the ventricular mass fraction supplied by the right coronary ("Right Coronary/Ventricular Weight"). Different coloured gel injected through both coronary artery's capillary beds allowed ventricular myocardium separation to obtain the weights. In hearts without hypertrophy, mean +/- standard deviation of the "Right Ventricle/Left Ventricle" mass ratio was 0.54 +/- 0.09 for males and 0.62 +/- 0.23 for females; "Right Coronary/Ventricular Weight" mass ratios were 0.39 +/- 0.08 and 0.39 +/- 0.04, respectively. Mean +/- standard deviation of the "Right Ventricle/Left Ventricle" and "Right Coronary/Ventricular Weight" ratios were 0.37 +/- 0.05 and 0.36 +/- 0.10, respectively in hearts with "Left Ventricle Hypertrophy"; 0.56 +/- 0.07 and 0.38 +/- 0.11 in hearts "Without Hypertrophy"; 0.54 +/- 0.08 and 0.39 +/- 0.08 in hearts with "Biventricular Hypertrophy"; 0.89 +/- 0.16 and 0.49 +/- 0.06 in hearts with "Right Ventricle Hypertrophy". Means and variances are narrower for the "Right Coronary/Ventricular Weight" than that observed for the "Right Ventricle/Left Ventricle" mass ratio. It is due to the special double coronary arrangement in which every artery irrigates both ventricles. These results suggest that the usual pattern of the human coronary arteries' anatomy acts as a buffer for the ventricular mass distribution to be irrigated by both arteries in hypertrophy.
de Oliveira
J A
JA
Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002102:Cadaver; D003331:Coronary Vessels / Q000033:anatomy & histology* / Q000473:pathology; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000473:pathology*; D017380:Hypertrophy, Right Ventricular / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011446:Prospective Studies; D012016:Reference Values; D012737:Sex Factors