[The effect of morphine and pentazocine on thrombocyte functional activity].
The effect of morphine (0.02 and 0.05 mg/ml) and pentazocine (0.05, 0.1, and 0.2 mg/ml) on blood platelet aggregation induced by thrombin, ADP, and epinephrine was studied. The results of the study provide evidence of the dose-dependent effect of opiates on human and rat blood platelets, and some species characteristics. Certain differences in the intensity of aggregation depending on the content of extracellular Ca2+ ions were disclosed.
Ignatov
Iu D
IuD
Petrishchev
N N
NN
Mitreĭkin
V F
VF
D000328:Adult; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D010423:Pentazocine / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013045:Species Specificity
D009294:Narcotics; D009020:Morphine; D010423:Pentazocine; D002118:Calcium