[The relationship of vascular changes and immune status disorders in patients with diabetes mellitus type 1].
Immunologic status was studied in 86 patients with type-I diabetes mellitus before and after treatment with decarise, thymaline and T-activin. With the aid of ECG, phonocardiogramme, apex cardiogramme, oscillogramme, there has been calculated index of vitality of the myocardium reflecting the subendocardial bloodflow. The principal parameters characterising bodily immune status (absolute number of T- and B-lymphocytes), T-suppressors counts as well as those of circulating immune complexes (CIC) were compared to the values for subendocardial bloodflow (end-diastolic pressure, index of vitality of the myocardium). There has been established strong inverse relation between the absolute numbers of T-, B-lymphocytes, and CIC, end-diastolic pressure and index of vitality of the myocardium, this being regarded as evidence in confirmation of the guarding role of the former and damaging one of the latter (CIC) under vascular pathology in diabetes mellitus.
Garagan
S F
SF
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D003925:Diabetic Angiopathies / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007111:Immunity, Cellular / Q000187:drug effects; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged
D000276:Adjuvants, Immunologic; D007004:Hypoglycemic Agents; D007328:Insulin