[Mechanism of inhibitory action of sodium ferulate on liver lipid peroxidation in mice].
The study has shown that sodium ferulate (SF) significantly inhibits the rise of liver lipid peroxides MDA content, alleviates the depletion of hepatic GSH pond, and reverses the decline of GST, GSH-Px levels in ethanol treated mice. The results indicate this inhibitory action of SF is related to diminishing the generation of oxygen free radicals by stabilizing GSH and related enzyme levels.
Wu
D
D
Clinical Pharmaceutical Department, Hubei Medical University, Wuhan.
Zhang
H
H
Zhou
B
B
Cai
H
H
D000818:Animals; D003373:Coumaric Acids / Q000494:pharmacology*; D000431:Ethanol; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006519:Hepatitis, Alcoholic / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice
D003373:Coumaric Acids; D016166:Free Radical Scavengers; D000431:Ethanol; C004999:ferulic acid