Effect of Panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats.
1 The effect of pharmacological pretreatment (pyridostigmine, benactyzine and trihexyphenidyle), designated Panpal, and antidotal treatment (the oxime HI-6 plus benactyzine) in soman poisoning was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. 2 Soman poisoning caused a high decrease in respiratory rate as well as minute respiratory volume and an increase in mean arterial pressure from 30-120 min following soman challenge. Soman at sublethal dose also significantly inhibited acetylcholinesterase activity in diaphragm and various brain parts. 3 Panpal pretreatment as well as antidotal treatment were effective in improving the respiratory and circulatory function disturbed by soman without the ability to increase significantly soman-inhibited acetylcholinesterase activity in all brain parts studied. 4 The efficacy of combined Panpal pretreatment and antidotal treatment against sublethal soman poisoning was not different from the efficacy of Panpal pretreatment or antidotal treatment alone. 5 The results of this investigation suggest that Panpal pretreatment as well as antidotal treatment are able to restore respiratory and circulatory function in soman-poisoned rats without significant reactivation of brain acetylcholinesterase.
Kassa
J
J
Purkynĕ Military Medical Academy, Hradec Králové, Czech Republic.
Fusek
J
J
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001535:Benactyzine / Q000008:administration & dosage* / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000201:enzymology; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D003964:Diaphragm / Q000201:enzymology; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D010091:Oximes; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D011729:Pyridostigmine Bromide / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects*; D012999:Soman / Q000633:toxicity*; D014282:Trihexyphenidyl / Q000008:administration & dosage*
D000931:Antidotes; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D010091:Oximes; D011726:Pyridinium Compounds; D001535:Benactyzine; D014282:Trihexyphenidyl; D012999:Soman; D000110:Acetylcholinesterase; C022870:asoxime chloride; D011729:Pyridostigmine Bromide