title: A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.
abstract: Natural killer (NK) cell-mediated lysis is negatively regulated by killer cell inhibitory receptors specific for major histocompatibility complex (MHC) class I molecules. In this study, we characterize a novel inhibitory MHC class I receptor of the immunoglobulin-superfamily, expressed not only by subsets of NK and T cells, but also by B cells, monocytes, macrophages, and dendritic cells. This receptor, called Ig-like transcript (ILT)2, binds MHC class I molecules and delivers a negative signal that inhibits killing by NK and T cells, as well as Ca2+ mobilization in B cells and myelomonocytic cells triggered through the B cell antigen receptor and human histocompatibility leukocyte antigens (HLA)-DR, respectively. In addition, myelomonocytic cells express receptors homologous to ILT2, which are characterized by extensive polymorphism and might recognize distinct HLA class I molecules. These results suggest that diverse leukocyte lineages have adopted recognition of self-MHC class I molecules as a common strategy to control cellular activation during an immune response.
authors.affiliation: Basel Institute for Immunology, Basel CH-4005, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Colonna
authors.forename: F
authors.initials: F
authors.lastname: Navarro
authors.forename: T
authors.initials: T
authors.lastname: Bellón
authors.forename: M
authors.initials: M
authors.lastname: Llano
authors.forename: P
authors.initials: P
authors.lastname: García
authors.forename: J
authors.initials: J
authors.lastname: Samaridis
authors.forename: L
authors.initials: L
authors.lastname: Angman
authors.forename: M
authors.initials: M
authors.lastname: Cella
authors.forename: M
authors.initials: M
authors.lastname: López-Botet
mesh_terms: D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD; D002118:Calcium / Q000378:metabolism; D002461:Cell Line, Transformed; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D006680:HLA Antigens / Q000378:metabolism*; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D015471:Leukemia, Basophilic, Acute / Q000473:pathology; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism*; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D009928:Organ Specificity; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012701:Serotonin / Q000378:metabolism; D018089:Superantigens / Q000276:immunology; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D006680:HLA Antigens; D006684:HLA-DR Antigens; D047908:Intracellular Signaling Peptides and Proteins; C105299:LILRB1 protein, human; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D011971:Receptors, Immunologic; D018089:Superantigens; D012701:Serotonin; C516724:PTPN11 protein, human; C509249:PTPN6 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases; D002118:Calcium