Sodium, blood pressure, and arterial distensibility in insulin-dependent diabetes mellitus.
We investigated 24-hour ambulatory blood pressure and arterial distensibility, a marker of biophysical vessel wall properties, in 32 normoalbuminuric type I diabetic patients and 32 healthy control subjects on diets containing 50 mmol and 200 mmol sodium per day. The increase in daytime diastolic blood pressure from 50 to 200 mmol sodium was significantly higher in the diabetic patients than in the control subjects (2.3+/-4.9 versus 0.2+/-3.7 mm Hg, P<.05). On a high sodium regimen, femoral artery distensibility was decreased in the diabetic patients compared with the control subjects (19.2+/-7.6 versus 24.1+/-9.3 10[-3]/kPa, P<.05). Angiotensin-converting enzyme inhibition in the diabetic patients on a high sodium diet decreased daytime diastolic blood pressure and increased femoral artery distensibility. The blood pressure decrease in response to angiotensin-converting enzyme inhibition correlated significantly with the blood pressure increase to sodium (for 24-hour systolic and diastolic blood pressure, r=.72, P<.001 and r=.76, P<.001). In addition, we found that in the diabetic patients on a high sodium diet, the renal blood flow response to exogenous angiotensin II was not bimodally distributed, as is the case in essential hypertension, in which a subgroup of the patients are characterized by sodium sensitivity of the blood pressure and an abnormal renal blood flow response to exogenous angiotensin II ("nonmodulator phenotype"). These results show that blood pressure in insulindependent diabetes mellitus is sodium sensitive, but that this is not related to the nonmodulator phenotype, and suggest that in IDDM a relatively high sodium intake may be a factor that predisposes to the development of diabetic vascular disease.
Lambert
J
J
Department of Internal Medicine, Academisch Ziekenhuis Vrije Universiteit, Armsterdam, The Netherlands.
Pijpers
R
R
van Ittersum
F J
FJ
Comans
E F
EF
Aarsen
M
M
Pieper
E J
EJ
Donker
A J
AJ
Stehouwer
C D
CD
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D001794:Blood Pressure / Q000502:physiology*; D003187:Compliance; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003971:Diastole; D004039:Diet, Sodium-Restricted; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D008297:Male; D012016:Reference Values; D012079:Renal Circulation / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors