title: MR assessment of red marrow distribution and composition in the proximal femur: correlation with clinical and laboratory parameters.
abstract: OBJECTIVE
  To correlate the MR appearance of the proximal femur marrow with clinical and blood parameters.
  
  
  METHODS
  The proportion of the femoral neck surface area occupied by red marrow was determined on T1-weighted magnetic resonance (MR) images of the hip in a series of 120 subjects, aged from 15 to 75 years, with ten females and ten males per decade, and correlated with clinical data. This parameter and the bulk T1 values of femoral red marrow were determined in 30 other subjects 25-46 years of age and correlated with their blood parameters.
  
  
  RESULTS
  In the series of 120 subjects, the proportion of red marrow surface area decreased with age (P < 10(-4)) and was higher in female than male subjects (P < 10(-4)). Within each decade, the proportion of red marrow surface area was higher in females than in males between 25 and 65 years but neither before 25 nor after 65 years. In the series of 30 subjects, the proportion of red marrow surface area and bulk T1 values of femoral red marrow were significantly negatively correlated with hemoglobin blood levels but not with blood cell counts.
  
  
  CONCLUSIONS
  The MR appearance of proximal femur red marrow is influenced by age and sex. A relationship with hemoglobin blood level is demonstrated.
authors.affiliation: Department of Radiology and Medical Imaging, University Hospital St. Luc, Brussels, Belgium.
authors.forename: B C
authors.initials: BC
authors.lastname: Vande Berg
authors.forename: F E
authors.initials: FE
authors.lastname: Lecouvet
authors.forename: P
authors.initials: P
authors.lastname: Moysan
authors.forename: B
authors.initials: B
authors.lastname: Maldague
authors.forename: J
authors.initials: J
authors.lastname: Jamart
authors.forename: J
authors.initials: J
authors.lastname: Malghem
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology; D001772:Blood Cell Count; D001853:Bone Marrow / Q000033:anatomy & histology*; D005260:Female; D005269:Femur / Q000033:anatomy & histology*; D006454:Hemoglobins; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012737:Sex Factors
chemical_list: D006454:Hemoglobins