Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats.
1. Dietary docosahexaenoic acid (DHA) suppressed the age-dependent increase in systolic blood pressure and prolonged the average survival time of stroke-prone spontaneously hypertensive rats (SHRSP). 2. Dietary DHA (1% and 5% in diets) altered the circadian rhythm of SHRSP, causing significant increases in ambulatory activity during the dark period. At the onset of stroke, desynchronization with light and dark phases and new biological rhythms were noted in all of the control SHRSP (DHA 0%). DHA treated SHRSP did not show such behavioral changes. 3. These effects were accompanied by the increase of DHA and the decrease of AA levels in plasma and brain cortex. 4. It was concluded that dietary DHA suppresses the development of hypertension and stroke-related behavioral changes, resulting in prolongation of the SHRSP's life span.
Minami
M
M
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
Kimura
S
S
Endo
T
T
Hamaue
N
N
Hirafuji
M
M
Monma
Y
Y
Togashi
H
H
Yoshioka
M
M
Saito
H
H
Watanabe
S
S
Kobayashi
T
T
Okuyama
H
H
D000375:Aging / Q000502:physiology; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002423:Cause of Death; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000523:psychology*; D002940:Circadian Rhythm / Q000187:drug effects; D004032:Diet; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D008017:Life Expectancy; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors
D008055:Lipids; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid