Differential effects of aging on NADPH-diaphorase and VIP neurons in cerebral cortex of rats.
Age-related changes of NADPH-diaphorase (NADPH-d) and vasoactive intestinal polypeptide (VIP) were examined in the rat brain. Aged (24 months) rats showed a significant decrease in the number of VIP-immunoreactive (IR) neurons in the cerebral cortex when compared with control (4 months) rats. However, the number of NADPH-d-positive neurons was not significantly different in the two groups. Quantitative analysis of cell areas revealed a significant shrinkage of VIP-IR neurons in the aged group, whereas no further cell shrinkage was noted for NADPH-d-positive neurons compared with the control group. These morphometric results demonstrate that NADPH-d-containing neurons are more resistant to aging than the VIP-IR neurons in the cerebral cortex of rats.
Huh
Y
Y
Department of Anatomy, College of Medicine, Kyunghee University, Seoul, South Korea.
Kim
C
C
Cho
J
J
Lee
W
W
Kim
J
J
Ahn
H
H
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002452:Cell Count; D048429:Cell Size; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D014660:Vasoactive Intestinal Peptide; D009252:NADPH Dehydrogenase