title: Iodised rapeseed oil for eradication of severe endemic goitre.
abstract: Iodised oil is traditionally based on the fatty acids (FAs) of the poppyseed, an expensive commodity. An equipotent but cheaper vehicle would be welcome. Iodination of rapeseed oil yields a product (Brassiodol) with a total iodine content of 376 mg/mL. Brassiodol has been compared with the poppyseed-based Lipiodol in two villages in Chad in the west African goitre belt. A 2 mL dose of Brassiodol is followed by urinary spillover of half the ingested iodine. The other half undergoes tissue sequestration and slow release, allowing protection against iodine deficiency for 9 months and regression of stage I/II goitre for longer than was achieved with Lipiodol. The prolonged protection offered by Brassiodol can be attributed to its unique lipid profile. The urinary output argues that 1 mL should not be exceeded, and at that dose the cost would be only 20 US cents per person per year.
authors.affiliation: Laboratory, Faculty of Pharmacy, University Louis Pasteur, Strasbourg, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Ingenbleek
authors.forename: L
authors.initials: L
authors.lastname: Jung
authors.forename: G
authors.initials: G
authors.lastname: Férard
authors.forename: F
authors.initials: F
authors.lastname: Bordet
authors.forename: A M
authors.initials: AM
authors.lastname: Goncalves
authors.forename: L
authors.initials: L
authors.lastname: Dechoux
mesh_terms: D000328:Adult; D001937:Brassica; D002596:Chad; D005227:Fatty Acids / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated; D005260:Female; D006043:Goiter, Endemic / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007455:Iodine / Q000172:deficiency / Q000652:urine; D007459:Iodized Oil / Q000627:therapeutic use*; D008297:Male; D010938:Plant Oils / Q000378:metabolism / Q000627:therapeutic use*; D000074262:Rapeseed Oil; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; D000074262:Rapeseed Oil; D013963:Thyroid Hormones; C109370:brassiodol; D007459:Iodized Oil; D007455:Iodine