Object-recognition and spatial learning and memory in rats prenatally exposed to ethanol.
Prenatal ethanol exposure can produce cognitive and behavioral impairments. In the present study, rats from prenatal ethanol (E), pair-fed (PF), and ad libitum-fed control (C) treatment conditions were tested on the object-recognition delayed-nonmatching-to-sample (DNMS) task with nonrecurring items and on the spatial-navigation Morris water maze task. In Experiment 1, there were no significant differences among groups in object-recognition learning and memory, distractibility, or response perseveration on the DNMS task. In Experiment 2, the same rats were tested in the water maze; E rats took significantly longer to learn the task than did the PF or C rats. These data suggest that the mechanisms underlying spatial cognitive abilities are more vulnerable to the teratogenic effects of prenatal ethanol exposure than those underlying object-recognition abilities.
Kim
C K
CK
Department of Anatomy, University of British Columbia, Vancouver, Canada. ckkim@aim.salk.edu
Kalynchuk
L E
LE
Kornecook
T J
TJ
Mumby
D G
DG
Dadgar
N A
NA
Pinel
J P
JP
Weinberg
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003463:Cues; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000503:physiopathology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D009949:Orientation / Q000187:drug effects* / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology; D012931:Social Environment
D000431:Ethanol