title: Skin necrosis secondary to low-molecular weight heparin in a patient with antiphospholipid antibody syndrome.
abstract: Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites. It occasionally accompanies the heparin-associated thrombocytopenia and thrombosis syndrome. We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Gibson
authors.forename: L E
authors.initials: LE
authors.lastname: Gibson
authors.forename: L A
authors.initials: LA
authors.lastname: Drage
authors.forename: C R
authors.initials: CR
authors.lastname: Garrett
authors.forename: M A
authors.initials: MA
authors.lastname: Gertz
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000628:therapy; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009336:Necrosis; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000150:complications / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight