Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.
The adipose cell is now known to play a complex role in energy homeostasis, storing energy and signaling to other tissues concerning the state of energy balance. The past several years have seen an explosive increase in our knowledge of the transcriptional basis of adipocyte differentiation. This review describes the role of peroxisome proliferator-activated receptor gamma in this process, and describes how other transcription factors may affect adipogenesis by modulating PPARgamma amount or activity. Furthermore, PPARgamma and other adipogenic transcription factors provide a focus for beginning to understand how various hormones and metabolites influence the development of this tissue in vivo.
Spiegelman
B M
BM
Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. Bruce_Spiegelman@dfci.harvard.edu
D000273:Adipose Tissue / Q000502:physiology*; D002001:Adipose Tissue, Brown / Q000502:physiology; D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology; D003920:Diabetes Mellitus / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology; D009765:Obesity / Q000503:physiopathology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D007328:Insulin; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D017871:Calcium-Calmodulin-Dependent Protein Kinases