title: The CD40 pathway in allograft rejection, acceptance, and tolerance.
abstract: The CD40 pathway plays a critical role at many levels of the sensitization and effector phases of allograft rejection. In addition to the important signaling role of this pathway for T cell help and effector function, recent evidence suggests that the CD40 pathway can directly co-stimulate T cells, independently of its effect on the B7-CD28 pathway.
authors.affiliation: Emory University, Atlanta, GA 30322, USA. clarsen@emory.org
authors.forename: C P
authors.initials: CP
authors.lastname: Larsen
authors.forename: T C
authors.initials: TC
authors.lastname: Pearson
mesh_terms: D019013:CD40 Antigens; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007108:Immune Tolerance; D016377:Organ Transplantation; D015398:Signal Transduction; D014184:Transplantation, Homologous
chemical_list: D019013:CD40 Antigens