In the clutches of proteoglycans: how does heparan sulfate regulate FGF binding?
Fibroblast growth factors and their receptors bind to heparan sulfate glycosaminoglycans. This is thought to promote ligand-receptor binding and enhance signaling by promoting receptor multimerization. Synthetic mimetics designed to occupy these binding sites may provide the means to understand and to regulate FGF signaling.
Rapraeger
A C
AC
Department of Pathology, University of Wisconsin, Madison 53706, USA.
D000818:Animals; D019812:Heparan Sulfate Proteoglycans / Q000494:pharmacology*; D006801:Humans; D009844:Oligosaccharides / Q000737:chemistry; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000187:drug effects / Q000378:metabolism*
D019812:Heparan Sulfate Proteoglycans; D009844:Oligosaccharides; D017468:Receptors, Fibroblast Growth Factor; D020794:Receptor Protein-Tyrosine Kinases