title: Continuous ambulatory radionuclide monitoring of left ventricular function: effect of body position during ergometer exercise.
abstract: We assessed the reliability of a continuous ambulatory radionuclide monitoring system (the VEST system, Capintec, Inc., Ramsey, NJ) for measurement of left ventricular performance during exercise in the upright and supine positions.
  
  
  METHODS
  Sixteen healthy male volunteers (aged 32-46 yr; mean age 37 +/- 4 yr) were studied. All volunteers underwent ergometer exercise testing in both the upright and supine positions, and left ventricular performance was determined with the VEST system.
  
  
  RESULTS
  The resting heart rate, systolic blood pressure, pressure rate product, relative end-diastolic volume, relative end-systolic volume and left ventricular ejection fraction (LVEF) all showed no differences between the upright and supine positions. At peak exercise, the heart rate, systolic blood pressure and pressure rate product showed no differences between the upright and supine positions. In the upright position at peak exercise the relative end-diastolic volume was increased (83% +/- 9% to 91% +/- 11%, p < 0.001); the relative end-systolic volume remained unchanged (34% +/- 3% to 33% +/- 15%), and LVEF was significantly increased from 58% +/- 6% to 66% +/- 11% (p < 0.01). In the supine position at peak exercise, the relative end-diastolic volume remained unchanged (85% +/- 5 to 83% +/- 7%), the relative end-systolic volume was increased (35% +/- 5% to 43% +/- 13%, p < 0.01), and LVEF was decreased from 58% +/- 5% to 48% +/- 17% (p < 0.01). These results indicated inferior data collection by the VEST system in the supine position.
  
  
  CONCLUSIONS
  Since the detector of the VEST system may be too small, the data collection is impaired during exercise in the supine position by shifting the heart with deep respiration. The VEST system is very useful for determining left ventricular performance when applied in the sitting or upright position. However, in the supine position during exercise, the use of the VEST system should be avoided because it might indicate an artifactual deterioration of left ventricular performance.
authors.affiliation: Second Department of Internal Medicine, Kyorin University School of Medicine, Mitaka-city, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mizuno
authors.forename: A
authors.initials: A
authors.lastname: Yanagisawa
authors.forename: T
authors.initials: T
authors.lastname: Shigeyama
authors.forename: M
authors.initials: M
authors.lastname: Taya
authors.forename: A
authors.initials: A
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Shimoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Tahara
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D000328:Adult; D005080:Exercise Test; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000379:methods; D011187:Posture; D015635:Radionuclide Ventriculography / Q000295:instrumentation*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D016683:Supine Position; D013668:Technetium Tc 99m Aggregated Albumin; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin