title: CDP-diacylglycerol synthase from mammalian tissues.
abstract: CDP-diacylglycerol resides at the branch point of glycerolipid biosynthesis as precursor of both the phosphoinositides and phosphatidylglycerol. The discovery of the phosphoinositide signal transduction pathway and the recognition of its prominent role in intracellular communication has focused new attention on CDP-diacylglycerol synthase. As a rate-limiting step in this pathway, it is a likely target for regulation. Exploration of this possibility will be facilitated by the recent cloning of mammalian CDP-DAG synthase.
authors.affiliation: Neuroscience Laboratory, University of Michigan, Ann Arbor 48104-1687, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Heacock
authors.forename: B W
authors.initials: BW
authors.lastname: Agranoff
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D002798:Diacylglycerol Cholinephosphotransferase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation; D013379:Substrate Specificity
chemical_list: D002798:Diacylglycerol Cholinephosphotransferase