title: Increased pulmonary flow velocities in oversized homografts in patients after the Ross procedure.
abstract: OBJECTIVE
  Between September 1991 and July 1996, 60 patients (mean age 29.8 +/- 9 years; range 5-57) underwent aortic root replacement with pulmonary autograft, a viable biologic and nondegenerating substitute. The pulmonary root was replaced with cryopreserved homografts from cardiac transplant recipients. The aim of this study was to evaluate differences in early valve function of viable and cryopreserved allografts.
  
  
  METHODS
  All patients had Doppler echocardiographic examinations preoperatively, at discharge from hospital and 54 patients at 1 year follow-up. We measured aortic and pulmonary peak flow velocities with continuous and pulsed-wave Doppler, and graded aortic and pulmonary insufficiency (AI, PI) with color Doppler flow (grade 0-IV). Intraoperatively, the diameters of the pulmonary root and the pulmonary homograft were measured with standard valve probes and matched to body surface area.
  
  
  RESULTS
  Pulmonary peak flow velocity (PVmax) increased significantly from preoperative 0.87 +/- 0.11 m/s to 1.30 +/- 0.34 m/s postoperatively (P < 0.001). The implanted homografts (mean 25.9 +/- 2.4 mm) were larger than their native pulmonary diameter (mean 23.3 +/- 1.8 mm) in all patients. Homograft size matched for body surface area (BSA) did not correlate with increased PVmax. There was a significant increase of PVmax at follow-up (FU) since discharge, also (1.83 +/- 0.53 m/s; P < 0.001). Pulsed-wave Doppler demonstrates that increase of PVmax is located directly at the homograft leaflets and not at the anastomoses. Aortic peak flow velocities (AVmax) were normal postoperatively and at FU (post = 1.35 +/- 0.35 m/s; FU = 1.17 +/- 0.27 m/s). There was no significant change in AI or PI since discharge (AI FU = 0.8 +/- 0.4; PI FU = 0.7 +/- 0.5). Eight patients with fever and symptoms diagnosed as post-pericardiotomy syndrome had significantly higher PVmax at FU (PVmax = 2.41 +/- 0.40 m/s; P < 0.02).
  
  
  CONCLUSIONS
  The Ross procedure leads to normal AVmax but significant increase of PVmax even in oversized cryopreserved homografts immediately after surgery. Further increase of PVmax without changes in AVmax in the first year demonstrates that changes in flow velocities are valve related and not due to increase in cardiac output. Further investigations will be necessary to determine whether this observation is due to valve rejection or early leaflet degeneration and treatment with immunosuppressive therapy is warranted.
authors.affiliation: Department of Surgery, University of Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Moidl
authors.forename: P
authors.initials: P
authors.lastname: Simon
authors.forename: N
authors.initials: N
authors.lastname: Kupilik
authors.forename: O
authors.initials: O
authors.lastname: Chevtchik
authors.forename: N
authors.initials: N
authors.lastname: Heinrich
authors.forename: A
authors.initials: A
authors.lastname: Moritz
authors.forename: E
authors.initials: E
authors.lastname: Wolner
authors.forename: G
authors.initials: G
authors.lastname: Laufer
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D001783:Blood Flow Velocity; D015925:Cryopreservation; D015150:Echocardiography, Doppler; D005260:Female; D006084:Graft Rejection; D006801:Humans; D008297:Male; D011651:Pulmonary Artery / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000502:physiology; D011664:Pulmonary Valve / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000637:transplantation*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014694:Ventricular Outflow Obstruction / Q000601:surgery