[Clinical significance of plasma alpha-granule membrane protein-140 in blood stasis of primary glomerular disease].
Plasma alpha-granule membrane protein 140(GMP-140) was determined in 53 patients of primary glomerular disease (PGD) with or without blood stasis. At the same time, the relationships between plasma GMP-140 and hyperlipoidemia and hypertension were investigated. Results showed that plasma GMP-140 in PGD patients was higher than that of normal control subjects, P < 0.01, platelet of patients was in a high activated status. The elevation was more significant in patient with blood stasis than in those without blood stasis, P < 0.01. Among the patients with blood stasis, plasma GMP-140 level in those with Qi-Deficiency was higher than that without Qi-Deficiency (P < 0.05). The above-mentioned results suggested that GMP-140 was an objective indicator for blood stasis of PGD patients. Deficiency of Qi could enhance platelet activation so as to aggravate the tendency of blood stasis. It was in accordance with the traditional Chinese medicine theory of "Qi-Deficiency induces blood stasis". Hyperlipoidemia and hypertension showed close relationship with abnormal increase of GMP-140, suggesting they play important roles in induction of hypercoagulability and blood stasis in PGD patients.
Li
X M
XM
Huashan Hospital, Shanghai Medical University.
Shi
S Z
SZ
Niu
H Z
HZ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005921:Glomerulonephritis / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood; D019007:P-Selectin / Q000378:metabolism*; D015539:Platelet Activation; D019413:Qi
D019007:P-Selectin