title: Epidermal growth factor receptor expression is associated with rapid tumor cell proliferation in renal cell carcinoma.
abstract: Epidermal growth factor receptor (EGF-r) expression and tumor cell proliferation rate have been proposed as potential prognostic parameters in renal cell carcinoma (RCC). In this study, immunohistochemical stains using antibodies to EGF-r and the cell proliferation marker Ki-67 (MIB-1) were used to study the relationship between EGF-r expression, tumor cell proliferation, and prognosis in 50 non-papillary RCC extending beyond the renal capsule (pT3). A high Ki-67 labeling index (LI) was associated with poor patient prognosis (P < .05). Thirty-eight cases (76%) expressed strong cell membrane immunoreactivity for EGF-r. There was a tendency toward a shortened survival for EGF-r-positive tumors (P = .08). Tumor growth fraction (Ki-67 LI) was significantly higher in EGF-r-positive tumors than in EGF-r-negative tumors (P < .05), suggesting that rapid tumor proliferation might be responsible for the poor prognosis associated with EGF-r-positive RCC.
authors.affiliation: Institute of Pathology, and the Department of Urology, University of Basel, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Moch
authors.forename: G
authors.initials: G
authors.lastname: Sauter
authors.forename: N
authors.initials: N
authors.lastname: Buchholz
authors.forename: T C
authors.initials: TC
authors.lastname: Gasser
authors.forename: L
authors.initials: L
authors.lastname: Bubendorf
authors.forename: F M
authors.initials: FM
authors.lastname: Waldman
authors.forename: M J
authors.initials: MJ
authors.lastname: Mihatsch
mesh_terms: D002292:Carcinoma, Renal Cell / Q000737:chemistry* / Q000175:diagnosis / Q000401:mortality; D002455:Cell Division; D066246:ErbB Receptors / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000401:mortality; D011379:Prognosis; D012044:Regression Analysis; D015996:Survival Rate
chemical_list: D019394:Ki-67 Antigen; D066246:ErbB Receptors