title: Plasma levels of diethylcarbamazine and their effects on implanted microfilariae of Brugia pahangi in rats.
abstract: Plasma level of diethylcarbamazine (DEC) was measured by using gas chromatography and was compared to the changes of microfilaremia after an intraperitoneal injection with 200 mg/kg of DEC in rats. The microfilaremia was induced artificially by an intravenous implantation with 2 x 10(5) Brugia pahangi microfilariae (mf) 1 day before DEC treatment. The rats treated with DEC showed a rapid and significant decrease in mf number in the circulation within 30 min, continued for 4 hr, and then increased rapidly. DEC seemed to cause transient but significant suppression of microfilaremia of B. pahangi in rats directly.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Agriculture, Miyazaki University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Horii
authors.forename: Y
authors.initials: Y
authors.lastname: Aoki
mesh_terms: D000818:Animals; D017179:Brugia pahangi / Q000187:drug effects* / Q000302:isolation & purification; D002849:Chromatography, Gas / Q000379:methods / Q000662:veterinary; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005368:Filariasis / Q000188:drug therapy / Q000662:veterinary*; D005369:Filaricides / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal / Q000379:methods / Q000662:veterinary; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D005369:Filaricides; D004049:Diethylcarbamazine