Multiple testing to establish superiority/equivalence of a new treatment compared with kappa standard treatments.
In this paper we develop multiple hypotheses testing procedures to compare a new treatment with a set of standard treatments in a clinical trial. The aim is to classify the new treatment with respect to each of the standards, by specifying those to which the new treatment is superior, those to which the new treatment is equivalent and those to which one can establish neither superiority nor equivalence. We propose several stepwise procedures and compare them with respect to their familywise error rates and power. The step-down methods SD1 and SD2 test for superiority first, followed by tests for equivalence for those comparisons where we cannot establish superiority. The step-up methods SU1 and SU2 test for equivalence first, followed by tests for superiority for those comparisons where we can establish at least equivalence. The methods SD3 and SU3 apply the tests for superiority and equivalence in pairs. All the methods require that we specify a threshold value delta > 0 in advance for defining equivalence. In applications where it is not possible to specify a value delta, we can use the method SD1 by testing for superiority first, followed by one-sided confidence limits on the efficacy differences for those comparisons where we cannot establish superiority.
Dunnett
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Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario, Canada.
Tamhane
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D002986:Clinical Trials as Topic; D003198:Computer Simulation; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D003955:Diagnostic Tests, Routine; D004358:Drug Therapy / Q000592:standards; D005069:Evaluation Studies as Topic; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D015233:Models, Statistical; D015999:Multivariate Analysis; D016032:Randomized Controlled Trials as Topic; D013223:Statistics as Topic; D013300:Streptokinase / Q000627:therapeutic use
D006493:Heparin; D013300:Streptokinase