Functional organization of cotransmission systems: lessons from small nervous systems.
Small invertebrate nervous systems allow one to ask a series of questions concerning the functional roles of cotransmitters. This review outlines some of the implications of cotransmission for target selectivity in complex neuropils. We suggest the possibility that a unique constellation of cotransmitters in individual identified modulatory neurons allows a specificity of action even when peptides may act over an extended distance, and when individual modulatory substances may be released from several modulatory neurons.
Marder
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E
Volen Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA.
Christie
A E
AE
Kilman
V L
VL
D000818:Animals; D007448:Invertebrates / Q000502:physiology*; D009424:Nervous System Physiological Phenomena; D018377:Neurotransmitter Agents / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D014018:Tissue Distribution
D018377:Neurotransmitter Agents