title: Failure of low dosage thrombolytic therapy with streptokinase to treat heparin-induced thrombocytopenic-thrombotic syndrome.
abstract: We report the case of a 58-year-old man affected by thrombocytopenic-thrombotic syndrome induced by therapy with subcutaneous unfractionated heparin for superficial phlebitis of the left inferior limb. Thrombolytic therapy with low-dosage streptokinase, reported as successful in a previous case described by other authors, was inefficacious and the patient's outcome was unfavourable. Thrombocytopenic-thrombotic syndrome may be a dreadful and often deadly consequence of heparin therapy, and its treatment needs investigation, owing to currently broadening use of anticoagulant treatment with both unfractionated and low molecular weight heparins.
authors.forename: C
authors.initials: C
authors.lastname: Rusconi
authors.forename: C
authors.initials: C
authors.lastname: Oneglia
authors.forename: T
authors.initials: T
authors.lastname: Sabatini
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D017809:Fatal Outcome; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000188:drug therapy*; D013300:Streptokinase / Q000008:administration & dosage*; D013924:Thrombophlebitis / Q000188:drug therapy; D017211:Treatment Failure
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D006493:Heparin; D013300:Streptokinase