title: Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients.
abstract: Fifty-six resetting trials were conducted across the subjective day in 43 young men using a three-cycle bright-light (approximately 10,000 lx). The phase-response curve (PRC) to these trials was assessed for the presence of a "dead zone" of photic insensitivity and was compared with another three-cycle PRC that had used a background of approximately 150 lx. To assess possible transients after the light stimulus, the trials were divided into 43 steady-state trials, which occurred after several baseline days, and 13 consecutive trials, which occurred immediately after a previous resetting trial. We found that 1) bright light induces phase shifts throughout subjective day with no apparent dead zone; 2) there is no evidence of transients in constant routine assessments of the fitted temperature minimum 1-2 days after completion of the resetting stimulus; and 3) the timing of background room light modulates the resetting response to bright light. These data indicate that the human circadian pacemaker is sensitive to light at virtually all circadian phases, implying that the entire 24-h pattern of light exposure contributes to entrainment.
authors.affiliation: Division of Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Jewett
authors.forename: D W
authors.initials: DW
authors.lastname: Rimmer
authors.forename: J F
authors.initials: JF
authors.lastname: Duffy
authors.forename: E B
authors.initials: EB
authors.lastname: Klerman
authors.forename: R E
authors.initials: RE
authors.lastname: Kronauer
authors.forename: C A
authors.initials: CA
authors.lastname: Czeisler
mesh_terms: D000328:Adult; D001683:Biological Clocks / Q000502:physiology*; D001831:Body Temperature; D002940:Circadian Rhythm / Q000502:physiology*; D003463:Cues; D006801:Humans; D008027:Light; D008029:Lighting; D008297:Male; D012890:Sleep; D013995:Time; D014851:Wakefulness