title: Near-total laryngectomy for treatment of advanced laryngeal cancer.
abstract: BACKGROUND
  In order to assess whether near-total laryngectomy (NTL) could successfully reach the cure and preserve the voice in advanced laryngeal cancer, we studied 28 patients with T3/T4 squamous cell carcinoma of the larynx treated with NTL in our institution.
  
  
  METHODS
  A retrospective analysis has been carried out from 1990 through 1994. We classified 24 patients as Stage III and 4 patients as Stage IV. All patients had lateral neck dissection. Survival was analyzed under the Kaplan-Meier method.
  
  
  RESULTS
  Twenty-six patients achieved voice preservation. Two patients in the bilateral neck dissection group had a metastatic lymph node on the opposite side. No patient had local recurrence. Three patients died of the disease, and 1 patient was salvaged with neck dissection. Three-year disease-free survival was 85%.
  
  
  CONCLUSIONS
  This technique is useful in the treatment of selected cases of advanced laryngeal cancer and achieves local control of the lesion in all cases. The survival is comparable with that of patients submitted to total laryngectomy, regarding the extent of lesion. Voice preservation can be achieved in most cases.
authors.affiliation: Head and Neck Service, Hospital do Cancer, National Cancer Institute/INCA, Rio de Janeiro, Brazil.
authors.forename: R A
authors.initials: RA
authors.lastname: Lima
authors.forename: E Q
authors.initials: EQ
authors.lastname: Freitas
authors.forename: J
authors.initials: J
authors.lastname: Kligerman
authors.forename: F P
authors.initials: FP
authors.lastname: Paiva
authors.forename: F L
authors.initials: FL
authors.lastname: Dias
authors.forename: M M
authors.initials: MM
authors.lastname: Barbosa
authors.forename: G M
authors.initials: GM
authors.lastname: Sa
authors.forename: J R
authors.initials: JR
authors.lastname: Soares
mesh_terms: D000206:Actuarial Analysis; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D013997:Time Factors