Sesame oil in injectable gold: two drugs in one?
To investigate the potential anti-inflammatory effects of sesame oil, which is present in the injectable gold preparation Auromyose, the synthesis of tumour necrosis factor alpha (TNF-alpha), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) by in vitro stimulated blood cells was measured before, during and after 12 weeks of dietary supplementation with 18 g of sesame oil daily in 11 healthy male volunteers. Neither TNF-alpha, PGE2 nor LTB4 production levels showed statistically significant changes during the 12 weeks of dietary supplementation with sesame oil. These results do not suggest an anti-inflammatory effect of sesame oil as present in injectable gold preparations which are used in the treatment of rheumatoid arthritis.
ten Wolde
S
S
Department of Rheumatology, University Hospital Leiden, The Netherlands.
Engels
F
F
Miltenburg
A M
AM
Kuijpers
E A
EA
Struijk-Wielinga
G I
GI
Dijkmans
B A
BA
D000293:Adolescent; D000328:Adult; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000178:diet therapy* / Q000188:drug therapy*; D002478:Cells, Cultured; D015232:Dinoprostone / Q000097:blood; D004338:Drug Combinations; D006046:Gold / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007273:Injections, Intramuscular; D007962:Leukocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D007975:Leukotriene B4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012715:Sesame Oil / Q000008:administration & dosage* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018501:Antirheumatic Agents; D004338:Drug Combinations; D014409:Tumor Necrosis Factor-alpha; D007975:Leukotriene B4; D006046:Gold; D012715:Sesame Oil; D015232:Dinoprostone