[2 stages in the formation of the humoral component of immunological reactivity in acantholytic pemphigus].
A study was made of the time course of the blood serum and plasma levels of large-, medium-, and small-sized CIC in patients with acantholytic pemphigus (n = 15) and healthy donors (n = 15). We could find no comparative data in the literature on blood serum and plasma CICs in acantholytic pemphigus (AP). Blood to be assayed was taken from those AP patients receiving course treatments by generally recognized techniques during AP progression, stabilization, and significant regression of the eruption. In the normal state as well as during progression and stabilization of the dermatosis manifestations large and medium CICs in plasma exceeded those in serum 1.3-2.2-fold. On the contrary, in plasma the above values got lower during the regression stage of the eruption (table). The findings available allow us to assume that there are two distinct stages in the process of formation of the humoral component of immunologic reactivity in AP.
Fedorych
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PV
D000051:Acantholysis / Q000276:immunology*; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000097:blood; D001327:Autoimmune Diseases / Q000276:immunology*; D001782:Blood Donors; D018450:Disease Progression; D006801:Humans; D010392:Pemphigus / Q000276:immunology*
D000936:Antigen-Antibody Complex