Mechanisms of cycloheximide-induced apoptosis in liver cells.
Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo, inducing c-myc, c-fos, c-jun and p53 genes and accumulation of sphingosine, a toxic product of the sphingomyelin cycle. These data support the hypothesis that continuous synthesis of labile protective proteins is required to restrain apoptosis in liver; sphingosine might be important in mediating cycloheximide-induced apoptosis as an endogenous modulator of protein kinase C activity.
Alessenko
A V
AV
Institute of Biochemical Physics RAS, Moscow, Russia. aless@center.chph.ras.ru
Boikov PYa
Filippova
G N
GN
Khrenov
A V
AV
Loginov
A S
AS
Makarieva
E D
ED
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003513:Cycloheximide / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008854:Microscopy, Electron; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D011500:Protein Synthesis Inhibitors; D003513:Cycloheximide