Interleukin-2 production by human pre-implantation embryos.
The study was conducted to determine whether pre-implantation embryos secrete interleukin-2. Conditioned media of 27 embryos derived from women during in vitro fertilization (IVF) cycles were analyzed for interleukin-2 concentration. The results showed that conditioned embryo medium from the two pronuclei stage to 24 hours later contains interleukin-2. Endometrial large granular lymphocytes, which are probably involved in placentation, replicate in response to interleukin-2. It may therefore be speculated that interleukin-2 secreted by human embryos may modulate the function and replication of large granular lymphocytes.
Orvieto
R
R
Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel.
Bar-Hava
I
I
Schwartz
A
A
Shelef
M
M
Ben-Rafael
Z
Z
D001755:Blastocyst / Q000378:metabolism*; D017077:Culture Media, Conditioned; D046508:Culture Techniques; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D011247:Pregnancy
D017077:Culture Media, Conditioned; D007376:Interleukin-2