Differentiation commitment in normal hemopoiesis and leukemic transformation.
Differentiation commitment events are essential for the initiation of hemopoiesis and, in one form or another, occur continuously during adult hemopoiesis. The most studied type of differentiation commitment decision a hemopoietic cell can make involves the alternative choice of self-renewal versus the formation of progeny destined for maturation. Aberration in this commitment choice is a key abnormality necessary for the formation of a leukemic population.
Metcalf
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Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Nicola
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Robb
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D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D006410:Hematopoiesis / Q000502:physiology*; D007942:Leukemia, Experimental / Q000473:pathology / Q000503:physiopathology*; D012016:Reference Values