[Lipoprotein (a) in children with end stage renal failure on maintenance hemodialysis and continuous ambulatory peritoneal dialysis].
The aim of this study was to evaluate serum lipid abnormalities, particularly lipoprotein (a) [Lp(a)] in children with end-stage renal failure undergoing chronic dialysis and to estimate the influence of treatment method on these disturbances. Studies were performed on 21 children aged +/- 14.8 years (10 girls, 11 boys) on maintenance hemodialysis and 10 children, aged 13.2 years (8 girls, 2 boys) on CAPD. Control group consisted of 27 healthy age-matched subjects. All children were tested for concentration of serum Lp(a), total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C). It was found a significantly increase in Lp(a), TG, TC, LDL-C and significantly decrease in HDL-C in all dialysed children compared to controls. CAPD patients had markedly elevated serum Lp(a) and TG compared to hemodialysed children. These results suggest that CAPD treatment may contribute to the pathogenesis of lipid abnormalities and increased risk of developing coronary heart disease.
Zwolińska
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Katedry i Kliniki Nefrologii Pediatrycznej Akademii Medycznej we Wrocawiu.
Szprynger
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D000293:Adolescent; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000209:etiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D014280:Triglycerides; D002784:Cholesterol