title: Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli.
abstract: Quinolonyl-beta-lactam antimicrobial agents (QLAs) contain quinolones chemically linked to beta-lactams, although the impact of linkage is poorly understood. Genetically defined Escherichia coli strains were used to determine structure-activity characteristics of three quinolone-penem QLAs. Results suggest that the leaving group resulting from beta-lactam hydrolysis may not be free quinolone.
authors.affiliation: Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA. antone@creighton.edu
authors.forename: A F
authors.initials: AF
authors.lastname: Ehrhardt
authors.forename: C C
authors.initials: CC
authors.lastname: Sanders
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents