Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent.
As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE epsilon4 allele frequency was significantly increased in AD patients compared with controls. The age-adjusted odds ratio (OR) for AD in epsilon4 homozygotes was 4.83 (95% confidence interval [CI], 1.71-13.64) compared with the epsilon3/epsilon3 genotype, but the OR for AD with the epsilon3/epsilon4 genotype did not reach significance (1.20; 95% CI, 0.58-2.45). These findings suggest that the association between ApoE epsilon4 and AD is weaker in African Americans than in whites.
Sahota
A
A
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202-5111, USA.
Yang
M
M
Gao
S
S
Hui
S L
SL
Baiyewu
O
O
Gureje
O
O
Oluwole
S
S
Ogunniyi
A
A
Hall
K S
KS
Hendrie
H C
HC
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D014481:United States; D001741:Black or African American
D001057:Apolipoproteins E