Evolving methods in genetic epidemiology. IV. Approaches to non-Mendelian inheritance.
From this overview it can be concluded that the understanding of the biologic properties and the development of analytic tools to identify repeat sequence mutations, genomic imprinting effects, and mitochondrial mutations are only beginning. Development of approaches to identify such phenomena as modifying effects or genetic components of complex traits is a new area of research. Not mentioned here are the ways in which locating a gene with such properties (i.e., linkage analysis) would be affected if such properties were not accounted for, or how to alter such analyses to obtain full information. Again, this is an exciting new area of research that will continue to motivate epidemiologists and geneticists. Hopefully, we have learned a lesson from the earlier conclusions of the studies on myotonic dystrophy: keep an open mind and never assume that the "geneticist should know best about behavior of genes".
Sherman
S L
SL
Department of Genetics, Emory University, Atlanta, GA 30322, USA.
D004812:Epidemiologic Methods; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D006801:Humans