title: Development: morphogen gradients and mesodermal patterning.
abstract: Activin has long-range effects in Xenopus development, inducing the mesodermally expressed brachyury gene up to 10 cell diameters from a localised source. Recent experiments show that activin diffuses through tissues to establish a morphogen gradient, and that the long-range effects are a direct result of activin signalling.
authors.affiliation: Department of Anatomy and Developmental Biology, University College London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Dale
mesh_terms: D028341:Activins; D000818:Animals; D019521:Body Patterning / Q000187:drug effects / Q000235:genetics*; D006133:Growth Substances / Q000502:physiology*; D007265:Inhibins / Q000502:physiology; D008648:Mesoderm / Q000187:drug effects / Q000502:physiology*; D014981:Xenopus / Q000196:embryology* / Q000235:genetics*
chemical_list: D006133:Growth Substances; D028341:Activins; D007265:Inhibins