title: Changes in inflammatory mediators during orthotopic liver transplantation.
abstract: Transplantation is associated with an inflammatory rejection response. Graft reperfusion causes typical haemodynamic and biochemical responses. In this study we have investigated the relationship between these haemodynamic responses and changes in circulating inflammatory mediators after graft reperfusion in 10 consecutive patients undergoing orthotopic liver transplantation. After reperfusion, systemic vascular resistance index decreased (P = 0.011) and cardiac index increased (P = 0.038). These characteristic haemodynamic changes of the reperfusion syndrome were accompanied by global increases in cytokine concentrations. Plasma concentrations of leukotrienes decreased, while thromboxane B2 and platelet activating factor remained increased throughout. Reperfusion-mediated changes in inflammatory mediators may account for the haemodynamic disturbance.
authors.affiliation: Intensive Care Unit, St James's University Hospital, Leeds.
authors.forename: M C
authors.initials: MC
authors.lastname: Bellamy
authors.forename: H F
authors.initials: HF
authors.lastname: Galley
authors.forename: N R
authors.initials: NR
authors.lastname: Webster
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood; D005260:Female; D006439:Hemodynamics; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007432:Intraoperative Period; D015289:Leukotrienes / Q000097:blood; D016031:Liver Transplantation / Q000276:immunology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000378:metabolism; D015424:Reperfusion; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D015289:Leukotrienes; D010972:Platelet Activating Factor; D013929:Thromboxane B2