[The pharmacological correction of respiratory musculature fatigue].
The effect of drugs (ATP, dibasol, corglycon, prednisolone, pyracetam, ethymysol, and aminophylline) on contractility of the diaphragm and the parameters of external respiration in inspiratory fatigue was studied. Total bioelectric activity of the diaphragm, transdiaphragmatic pressure, respiratory rate, tidal volume, and duty cycle were recorded in 160 anesthetized cats. Administration of the drugs under study normalized to a different measure the parameters of external respiration and improved contractility of the diaphragm in inspiratory fatigue. Aminophylline, pyracetam, corglycon, and ATP possessed the highest activity.
Vinogradova
I A
IA
Shevchenko
A I
AI
D000818:Animals; D002415:Cats; D004353:Drug Evaluation, Preclinical; D004576:Electromyography / Q000187:drug effects; D018763:Muscle Fatigue / Q000187:drug effects*; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000503:physiopathology; D015656:Respiratory Mechanics / Q000187:drug effects; D012132:Respiratory Muscles / Q000187:drug effects* / Q000503:physiopathology; D019141:Respiratory System Agents / Q000494:pharmacology / Q000627:therapeutic use*; D013147:Spirometry
D019141:Respiratory System Agents