title: [Cutaneous B-cell lymphoma with aggressive clinical presentation: apropos of a case].
abstract: A patient with an atypical clinical presentation of cutaneous B-cell lymphoma is reported. He showed a rapidly growing tumour with areas of skin necrosis, haemorrhage, ulceration and suppuration in his upper back. There were involvement of contiguous anatomic site and extracutaneous spread. The histology showed diffuse lymphoid infiltration of the dermis. The cell morphology was that of a monotonous population of centroblasts. Treatment with CHOP and radiotherapy provided long-term complete remission. This case illustrates that primary cutaneous B-cell lymphoma may behave as a high-grade malignancy. Vigorous treatment with chemotherapy and radiotherapy is recommended in such cases.
authors.affiliation: Servicio de Hematología-Hemoterapia, Hospital Lluís Alcanyís, Xàtiva, Valencia, España.
authors.forename: E
authors.initials: E
authors.lastname: Grau
authors.forename: E
authors.initials: E
authors.lastname: Real
authors.forename: M
authors.initials: M
authors.lastname: Perella
authors.forename: J
authors.initials: J
authors.lastname: Escandon
authors.forename: E
authors.initials: E
authors.lastname: Pastor
authors.forename: A
authors.initials: A
authors.lastname: Gómez
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D012883:Skin Ulcer / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone