Functional property, norepinephrine content and morphometric findings in human hyperplastic prostate.
BACKGROUND
Although alpha-adrenergic blockers are widely used as a treatment of benign prostatic hyperplasia (BPH), it is not clear whether contractile property of hyperplastic prostate to alpha-adrenergic agonist depends upon an area of density of smooth muscle within the respective BPH tissue.


METHODS
Functional study and quantitative morphometric analysis were performed on human prostatic specimens obtained by transurethral resection from 22 men with symptomatic BPH. Tissue norepinephrine content was also evaluated.


RESULTS
There was a linear correlation between the area of density of smooth muscle and maximum response to phenylephrine (r = 0.457, P = 0.0362). Although the area of density of smooth muscle showed a positive correlation with norepinephrine content (r = 0.437, P = 0.0471), norepinephrine content was not correlated with maximum phenylephrine response.


CONCLUSIONS
Contractile response to alpha-adrenergic agonist was directly influenced by the area of density of the smooth muscle within an individual prostate.
Ishigooka
M
M
Department of Urology, Yamagata University School of Medicine, Japan. mishigo@med.id.yamagata-u.ac.jp
Hashimoto
T
T
Suzuki
Y
Y
Ichiyanagi
O
O
Sasagawa
I
I
Aoyama
N
N
Nakada
T
T
D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism*; D011468:Prostatectomy / Q000379:methods; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D014521:Urethra
D009638:Norepinephrine