CD30+ lymphocytes in chronic gingivitis from HIV-positive patients: a pilot study.
Th2 type lymphocytes are characterized by high expression of CD30 glycoprotein. Increased serum levels of CD30 and Th2 IL-4 producing T-cells are found during AIDS progression. Since HIV-positive patients are more susceptible to periodontal disease, quantitative analysis of positive cells for the CD30 receptor in chronic gingivitis of both HIV-infected and non-infected patients (NSG) would help to clarify the immunoregulation of HIV-associated periodontal diseases. The purpose of this study was to evaluate CD30+ lymphocytes in gingival biopsies from sites exhibiting chronic gingivitis on HIV-positive patients (CG-HIV) and NSG. A biotin-streptavidin amplified system was used for identification of the CD30 receptor. The results demonstrated increased proportions of Th2 cells in CG-HIV as compared to NSG. Additional studies are necessary to understand the importance of these cells to the biological activity or inactivity of the disease.
Gomez
R S
RS
Department of Oral Surgery and Pathology, School of Dentistry, Minas Gerais Federal University, Belo Horizonte, Brazil.
de Souza
P E
PE
da Costa
J E
JE
Araújo
N S
NS
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000328:Adult; D001706:Biopsy; D001710:Biotin; D053285:CD30 Ligand; D016022:Case-Control Studies; D002908:Chronic Disease; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D005891:Gingivitis / Q000276:immunology*; D018023:HIV Seronegativity / Q000276:immunology; D006679:HIV Seropositivity / Q000276:immunology*; D006801:Humans; D007202:Indicators and Reagents; D015847:Interleukin-4 / Q000097:blood; D017730:Ki-1 Antigen / Q000032:analysis* / Q000097:blood; D008024:Ligands; D018655:Lymphocyte Count; D008562:Membrane Glycoproteins / Q000032:analysis; D008875:Middle Aged; D010865:Pilot Projects; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D019809:Streptavidin; D013601:T-Lymphocytes / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology*
D053285:CD30 Ligand; D007202:Indicators and Reagents; D017730:Ki-1 Antigen; D008024:Ligands; D008562:Membrane Glycoproteins; D011948:Receptors, Antigen, T-Cell; C505774:TNFSF8 protein, human; D015847:Interleukin-4; D001710:Biotin; D019809:Streptavidin