Bovine spongiform encephalopathy: is it an autoimmune disease due to bacteria showing molecular mimicry with brain antigens?
Bovine spongiform encephalopathy (BSE) could be an autoimmune disease produced following exposure of cattle to feedstuffs containing bacteria showing molecular mimicry between bacterial components and bovine tissue. Analysis of molecular sequence databases (Genbank and SwissProt) shows that three bacteria (Acinetobacter calcoaceticus,Ruminococcus albus, and Agrobacter tumefaciens) share sequences with the encephalitogenic peptide of bovine myelin, while three molecules in Escherichia coli show molecular mimicry with host-encoded prion protein. Immune responses against these bacteria at both T and B cell levels may cause neurological tissue injury resembling BSE. The role of these bacteria in BSE, if any, merits further investigation.
Ebringer
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A
Division of Life Sciences, Infection and Immunity Group and Department of Computing, King's College, Campden Hill Road, London, United Kingdom.
Thorpe
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C
Pirt
J
J
Wilson
C
C
Cunningham
P
P
Ettelaie
C
C
D000821:Animal Feed / Q000382:microbiology; D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D001921:Brain / Q000276:immunology; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000235:genetics* / Q000276:immunology; D018716:Molecular Mimicry / Q000276:immunology*; D008969:Molecular Sequence Data
D000942:Antigens, Bacterial