title: Immune response to the filaria Litomosoides sigmodontis in susceptible and resistant mice.
abstract: Comparisons were made between the immune responses evoked during the course of chronic and patient infections of Litomosoides sigmodontis in susceptible BALB/c mice and non-patent infections in resistant B10.D2 mice. Early antigen specific responses of spleen cells were weak in both mouse strains. However, by day 58 post infection a strong Th2 response, as determined by production of IL-4, IL-5 and IL-10, was observed in BALB/c mice but not in B10.D2 mice. Antibody responses seemed to appear sooner in B10.D2 than in BALB/c mice, and these differentially recognised two antigens of 15 kD and 80 kD.
authors.affiliation: Laboratoire de Biologie Parasitaire, Protistologie, Helminthologie, URA 114 associé au CNRS, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Maréchal
authors.forename: L
authors.initials: L
authors.lastname: Le Goff
authors.forename: W
authors.initials: W
authors.lastname: Hoffman
authors.forename: J
authors.initials: J
authors.lastname: Rapp
authors.forename: I P
authors.initials: IP
authors.lastname: Oswald
authors.forename: C
authors.initials: C
authors.lastname: Ombrouck
authors.forename: D W
authors.initials: DW
authors.lastname: Taylor
authors.forename: O
authors.initials: O
authors.lastname: Bain
authors.forename: G
authors.initials: G
authors.lastname: Petit
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis* / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology; D002455:Cell Division; D005260:Female; D005368:Filariasis / Q000276:immunology* / Q000469:parasitology; D005370:Filarioidea / Q000276:immunology; D007113:Immunity, Innate; D015847:Interleukin-4 / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018418:Th2 Cells / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015847:Interleukin-4