Direct chiral resolution of tiaprofenic acid in pharmaceutical formulations by capillary zone electrophoresis using cyclodextrins as chiral selector.
Capillary zone electrophoresis (CZE) was used for the enantiomeric separation of (R,S)-tiaprofenic acid ([R,S]-Tia) in a pharmaceutical formulation employing an acetate buffer at pH 4.5 and 2,3,6-tri-O-methyl-beta-cyclodextrin (tri-OMe-beta-CD) as the chiral selector. The effect of the concentration of trimethylated-beta-cyclodextrin in the presence of carboxymethylated-beta-cyclodextrin (CM-beta-CD) on enantiomeric resolution of (R,S)-Tia and (R,S)-5-benzoyl-alpha-methyl-3-thiopheneacetic acid (3-isomer of tiaprofenic acid, 3-Tia) was investigated at pH 4, 4.5, and 5.
Aturki
Z
Z
Istituto di Cromatografia del C.N.R., Area della Ricerca di Roma, Italy.
Camera
E
E
La Torre
F
F
Fanali
S
S
D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods*; D011422:Propionates / Q000032:analysis* / Q000737:chemistry / Q000493:pharmacokinetics
D003505:Cyclodextrins; D011422:Propionates; C021270:tiaprofenic acid