A novel cell cycle-dependent antinuclear antibody in a patient with a monoclonal gammopathy of unknown significance.
A patient with a monoclonal gammopathy, an erosive polyarthritis and a spastic paraparesis of both legs revealed a high titer of antinuclear antibodies with an immunofluorescence pattern hitherto unknown. A pleomorphic staining pattern of unsynchronized cells suggested a cell cycle-dependent autoantigen. Cell cycle-dependency of the antigen was confirmed by staining tissue sections, serum-starvation of tissue culture cells and mitogen-stimulation of peripheral blood lymphocytes. The antinuclear antibody does not belong to the paraprotein fraction of the serum immunoglobulins.
Zuber
M
M
University of Saarland Medical Center, Internal Medicine I, Homburg D-66421, Germany.
Pfreundschuh
M
M
Sörensen
H
H
D016475:3T3 Cells; D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood*; D001168:Arthritis / Q000150:complications / Q000276:immunology; D002453:Cell Cycle; D002467:Cell Nucleus / Q000276:immunology / Q000648:ultrastructure; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D015493:Paraparesis, Tropical Spastic / Q000150:complications / Q000276:immunology; D010265:Paraproteinemias / Q000097:blood / Q000150:complications / Q000276:immunology*; D051381:Rats; D014407:Tumor Cells, Cultured
D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains