Changing concepts in fibrinolysis.
New advances in molecular biology have prompted reevaluation of traditional concepts in fibrinolysis. Identification of novel cell surface activation receptors as well as a series of plasminogen/apolipoprotein(a) homologues suggests new potential mechanisms for controlled generation of the multifunctional protease plasmin.
Hajjar
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Department of Pediatrics, Cornell University Medical College, New York, NY 10021, USA.
D000818:Animals; D030801:Animals, Genetically Modified; D017306:Annexin A2 / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D005337:Fibrin / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology*; D024243:HMGB1 Protein; D006609:High Mobility Group Proteins / Q000502:physiology; D006801:Humans; D018082:Kringles; D011956:Receptors, Cell Surface / Q000502:physiology
D017306:Annexin A2; D002352:Carrier Proteins; D024243:HMGB1 Protein; D006609:High Mobility Group Proteins; D011956:Receptors, Cell Surface; D005337:Fibrin