title: Prevalence of carcinoma in situ of the testis in 207 oligozoospermic men from infertile couples: prospective study of testicular biopsies.
abstract: OBJECTIVE
  To investigate the prevalence of carcinoma in situ of the testis in a group of oligozoospermic men from infertile couples.
  
  
  METHODS
  A consecutive group of oligozoospermic men from infertile couples were offered bilateral testicular biopsy. The observed prevalence of carcinoma in situ was compared with the expected prevalence of testicular cancer in a corresponding age matched population of Danish men, assuming all untreated cases of carcinoma in situ progress to tumour stage. This calculation was based on data from the Danish Cancer Registry.
  
  
  METHODS
  207 men aged 18-50 years who had sperm density below 10 million/ml in two samples within the previous 2 years or sperm density below 20 million/ml in two samples within the previous 2 years and a history of cryptorchidism or one or two atrophic testicles (orchidometer volume less than 15 cm3), or both.
  
  
  METHODS
  Bilateral testicular biopsies.
  
  
  METHODS
  Carcinoma in situ in the biopsy specimen.
  
  
  RESULTS
  No case of carcinoma in situ was found among the 207 men. The expected number in a normal age matched population of corresponding size was 0.8.
  
  
  CONCLUSIONS
  There is no increase in risk of carcinoma in situ of the testis in moderately oligozoospermic men of couples referred because of infertility.
authors.affiliation: Universtiy Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Giwercman
authors.forename: J K
authors.initials: JK
authors.lastname: Thomsen
authors.forename: J
authors.initials: J
authors.lastname: Hertz
authors.forename: J G
authors.initials: JG
authors.lastname: Berthelsen
authors.forename: V
authors.initials: V
authors.lastname: Jensen
authors.forename: B
authors.initials: B
authors.lastname: Meinecke
authors.forename: L
authors.initials: L
authors.lastname: Thormann
authors.forename: H H
authors.initials: HH
authors.lastname: Storm
authors.forename: N E
authors.initials: NE
authors.lastname: Skakkebaek
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000473:pathology; D003718:Denmark / Q000453:epidemiology; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000453:epidemiology / Q000473:pathology; D015995:Prevalence; D011446:Prospective Studies; D013736:Testicular Neoplasms / Q000453:epidemiology* / Q000473:pathology