Megaesophagus in rats.
The objective of this study was to determine whether myenteric denervation of the abdominal esophagus using benzalkonium chloride (BAC) leads to esophageal achalasia with changes of the muscle propria and epithelial cell proliferation. The treatment led to megaesophagus 3 months after BAC application. Denervation of the esophagus induced muscle hypertrophy and increased epithelial cell proliferation. The imbalance of the neurotransmitters may play a role in these morphokinetic changes.
Febrônio
L H
LH
Department of Morphology, Faculty of Medicine of Ribeirão Preto, SP, Brazil.
Britto-Garcia
S
S
de Oliveira
J S
JS
Zucoloto
S
S
D000818:Animals; D001548:Benzalkonium Compounds / Q000008:administration & dosage; D004195:Disease Models, Animal; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D004931:Esophageal Achalasia / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D007263:Infusions, Parenteral; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000473:pathology; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001548:Benzalkonium Compounds