title: [The effect of 3-hydroxypyridine derivatives on postischemic disorders in the autoregulatory reactions of the cerebral vessels].
abstract: Acute experiments on nembutal anesthetized rats showed improvement of cerebral blood flow autoregulation in the postischemic period under the effect of mexidol and the new 3-hydroxypyridine (3-HOP) derivatives LBK-10 and LBK-38 administered for prophylactic and therapeutic, purposes. The role of dopaminergic activity, solubility in lipids, and other factors in the mechanism of the activity of 3-HOP derivatives is analysed.
authors.forename: V E
authors.initials: VE
authors.lastname: Pogorelyĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Arl't
authors.forename: M D
authors.initials: MD
authors.lastname: Gaevyĭ
authors.forename: L D
authors.initials: LD
authors.lastname: Smirnov
authors.forename: V V
authors.initials: VV
authors.lastname: Gatsura
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000187:drug effects* / Q000503:physiopathology; D002550:Cerebral Veins / Q000187:drug effects / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006706:Homeostasis / Q000187:drug effects*; D010847:Picolines / Q000008:administration & dosage / Q000494:pharmacology*; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
chemical_list: D000975:Antioxidants; D010847:Picolines; D011725:Pyridines; C070020:emoxypine succinate; C023500:3-hydroxypyridine