[Inotropic effect of novel cardiotonic agent, vesnarinone--tests on anaesthetized dogs].
We studied the positive inotropic effect of the novel cardiotonic agent, vesnarinone on open chest and intact anaesthetized dogs hearts. The results indicate that vesnarinone has a dose-effect relationship on increasing the contractile force, LV dp/dt max and stroke volume, and it shortens the ejection time 21%. No effect on blood pressure and heart rate was noted. Vesnarione is more effective than amrinone in terms of positive inotropic effect.
Han
W
W
Department of Pharmacology, School of Pharmacy, Chengdu.
Wu
Y
Y
Zhang
Z
Z
Yang
Z
Z
Cai
G
G
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011719:Pyrazines; D011804:Quinolines / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013318:Stroke Volume / Q000187:drug effects
D002316:Cardiotonic Agents; D011719:Pyrazines; D011804:Quinolines; C041667:vesnarinone