Cerebral hemodynamics and metabolism during infant cardiac surgery. Mechanisms of injury and strategies for protection.
There is an established link between congenital heart disease and acquired brain injury, which relates to the dependence of the nervous system on a consistent and responsive supply of oxygen and glucose. The advances in the field of infant cardiac surgery have presented new and different challenges to the arena of child neurology. This review provides an overview of the mechanisms of neurologic injury and cerebral hemodynamics and metabolism during cardiac surgery. This review discusses current and future strategies for the management of children with congenital heart disease.
du Plessis
A J
AJ
Department of Neurology, Children's Hospital, Boston, MA 02115, USA.
D000137:Acid-Base Imbalance / Q000517:prevention & control; D001921:Brain / Q000378:metabolism; D001930:Brain Injuries / Q000209:etiology / Q000517:prevention & control; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000379:methods / Q000639:trends; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000379:methods; D006330:Heart Defects, Congenital / Q000150:complications / Q000601:surgery*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000379:methods; D002534:Hypoxia, Brain / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D007223:Infant; D016343:Monitoring, Intraoperative / Q000379:methods; D018696:Neuroprotective Agents / Q000627:therapeutic use; D015424:Reperfusion / Q000379:methods; D015427:Reperfusion Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control
D018696:Neuroprotective Agents