[Cholecystokinin-octapeptide (CCK-8) reverses experimental endotoxin shock].
The effects of CCK-8 on the mean arterial pressure (MAP), blood components and path-morphological changes during endotoxin shock (endotoxin, 8 mg/kg b.w.iv.) in rats, as well as on the 24 h mortality rate (MR) of the lead-sensitized rats in endotoxin shock (endotoxin 1 microgram/100 g b.w.iv.) were observed. The results showed that injection of CCK in ES rats led to an increase in MAP, and a reduction of hematocrit and platelet as well as white cell count; the mortality rate decreased and the lesion in main organs lessened. It is suggested that release of endogenous CCK has important protective action during endotoxin shock.
Ling
Y L
YL
Institute of Basic Medicine, Hebei Medical University, Shijiazhuang.
Huang
S S
SS
Wang
L F
LF
Zhang
J L
JL
Wan
M
M
Hao
R L
RL
D000818:Animals; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D006400:Hematocrit; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012772:Shock, Septic / Q000097:blood* / Q000473:pathology; D012844:Sincalide / Q000494:pharmacology*
D004731:Endotoxins; D012844:Sincalide