title: The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer.
abstract: OBJECTIVE
  To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF-RI) as a potential biochemical marker in women with cervical cancer.
  
  
  METHODS
  A prospective, case-controlled study.
  
  
  METHODS
  Seventy-one women with cervical cancer and 33 women with myoma were enrolled in this study.
  
  
  METHODS
  Pre-operative serum levels of sTNF-RI were measured with a standard enzyme-linked immunosorbent assay utilising murine monoclonal antibody against sTNF-RI.
  
  
  METHODS
  All data in both groups were evaluated and correlated with the pre-operative serum levels of sTNF-RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression.
  
  
  RESULTS
  The mean serum level of sTNF-RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF-RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF-RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF-RI and tumour size (r = -0.622, P < 0.0001).
  
  
  CONCLUSIONS
  Decreased pre-operative serum levels of sTNF-RI are observed in women with cervical cancer. The results do not support that the use of sTNF-RI as a biochemical marker for cervical cancer.
authors.affiliation: Department of Obstetrics and Gynaecology, College of Medicine and the Hospital, National Taiwan University, Taipei, ROC.
authors.forename: B C
authors.initials: BC
authors.lastname: Sheu
authors.forename: H H
authors.initials: HH
authors.lastname: Lin
authors.forename: D Y
authors.initials: DY
authors.lastname: Chang
authors.forename: H N
authors.initials: HN
authors.lastname: Ho
authors.forename: S C
authors.initials: SC
authors.lastname: Huang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000175:diagnosis*; D008875:Middle Aged; D011446:Prospective Studies; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000175:diagnosis; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D018124:Receptors, Tumor Necrosis Factor