Role of poly(ADP-ribose) synthetase activation in the suppression of cellular energetics in response to nitric oxide and peroxynitrite.
Szabó
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Children's Hospital Medical Center, Division of Critical Care, Cincinnati, OH 45229, USA.
D000818:Animals; D004249:DNA Damage; D003920:Diabetes Mellitus / Q000503:physiopathology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D004789:Enzyme Activation; D006801:Humans; D017665:Hydroxyl Radical / Q000378:metabolism; D007249:Inflammation; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008954:Models, Biological; D009566:Nitrates / Q000494:pharmacology*; D009569:Nitric Oxide / Q000494:pharmacology*; D016877:Oxidants / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D015427:Reperfusion Injury / Q000503:physiopathology; D012769:Shock / Q000503:physiopathology
D009566:Nitrates; D016877:Oxidants; C039642:peroxynitric acid; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D011065:Poly(ADP-ribose) Polymerases