title: Chemodenervation in treatment of upper eyelid retraction.
abstract: Upper-eyelid retraction is a common sign of thyroid-associated eye disease (TAED), and these patients are highly bothered by the appearance of their eyes. In this study, botulinum toxin A (BTA) was injected into the levator palpebrae superioris muscle in 8 eyes of 4 patients in an attempt to control the abnormal elevation of the upper eyelid. BTA provided control of the upper-eyelid retraction, and the cosmetically acceptable effect lasted for 3-4 months. It was concluded that BTA is an effective method of treatment in this condition. Since it has a temporary effect, it can safely be used to provide relief of symptoms related to upper-eyelid retraction during unstabilized periods of TAED, which may last as long as several years in some patients.
authors.affiliation: SB Ankara Hospital, Turkey.
authors.forename: S B
authors.initials: SB
authors.lastname: Ozkan
authors.forename: D
authors.initials: D
authors.lastname: Can
authors.forename: M F
authors.initials: MF
authors.lastname: Söylev
authors.forename: A K
authors.initials: AK
authors.lastname: Arsan
authors.forename: S
authors.initials: S
authors.lastname: Duman
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005141:Eyelid Diseases / Q000209:etiology / Q000628:therapy*; D005143:Eyelids / Q000187:drug effects / Q000294:innervation*; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000150:complications; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009121:Muscle Denervation / Q000379:methods*; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D009801:Oculomotor Muscles / Q000187:drug effects / Q000294:innervation
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A