PLAB, a novel placental bone morphogenetic protein.
Bone morphogenetic proteins (BMP) constitute a sub-group of the large transforming growth factor-beta (TGF-beta) family. They play important roles in the embryonic development of multiple structures and in adult bone modeling. We have recently isolated a novel member of the BMP family from placenta, termed PLAB. PLAB is expressed highly in placenta, but can be found upon stringent analysis in low levels in most other tissues. At the amino acid level, PLAB is most closely related to BMP-8/OP-2, another member of the BMP family. Like TGF-beta, PLAB inhibits the proliferation of primitive hematopoietic progenitors. The high expression of PLAB by placenta raises the possibility that it may be a mediator of placental control of embryonic development.
Hromas
R
R
Department of Medicine and the Walther Oncology Center, Indiana University Medical Center, Indianapolis 46202, USA. robert_hromas@iucc.iupui.edu
Hufford
M
M
Sutton
J
J
Xu
D
D
Li
Y
Y
Lu
L
L
D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019485:Bone Morphogenetic Proteins / Q000235:genetics* / Q000502:physiology; D016207:Cytokines; D018076:DNA, Complementary; D055436:Growth Differentiation Factor 15; D051379:Mice; D008969:Molecular Sequence Data; D010920:Placenta / Q000378:metabolism*; D011257:Pregnancy Proteins / Q000235:genetics* / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D016212:Transforming Growth Factor beta / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D016207:Cytokines; D018076:DNA, Complementary; C526141:Gdf15 protein, mouse; D055436:Growth Differentiation Factor 15; D011257:Pregnancy Proteins; D016212:Transforming Growth Factor beta