title: Bath PUVA--an investigation of the distribution of trioxsalen (TMP) and 8-methoxypsoralen (8-MOP) in bathwater.
abstract: Trioxsalen (TMP) bath PUVA avoids the side effects of nausea and headache associated with oral 8-methoxypsoralen (8-MOP) treatment and allows shorter irradiation times that can be advantageous in some patients. However we noted that a number of patients developed unusual patterns of phototoxic burning. We thought that this was related to an uneven distribution of the TMP in the bathwater and for this reason, a study of bath water TMP concentrations achieved using different TMP preparations was undertaken. The distribution of 8-MOP in an 8-MOP bath was also measured for comparison. Our results confirm that an uneven distribution of TMP is achieved using TMP capsules or suspension and would explain our observed patterns of burning. With an ethanolic solution of TMP, or the commercial equivalent Tripsor, or with Puvasoralen-8 (an 8-MOP preparation), a homogeneous psoralen distribution is achieved, and they are therefore preferable for use in bath PUVA.
authors.affiliation: Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Wainwright
authors.forename: T M
authors.initials: TM
authors.lastname: MacLeod
authors.forename: J
authors.initials: J
authors.lastname: Ferguson
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D001494:Baths; D002214:Capsules; D000431:Ethanol / Q000008:administration & dosage; D006261:Headache / Q000517:prevention & control; D006801:Humans; D008730:Methoxsalen / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis*; D009325:Nausea / Q000517:prevention & control; D011701:PUVA Therapy; D010787:Photosensitivity Disorders / Q000139:chemically induced; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis*; D011829:Radiation Dosage; D012997:Solvents / Q000008:administration & dosage; D013535:Suspensions; D013997:Time Factors; D014307:Trioxsalen / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis*; D014867:Water / Q000032:analysis*
chemical_list: D002214:Capsules; D017319:Photosensitizing Agents; D012997:Solvents; D013535:Suspensions; D014867:Water; D000431:Ethanol; D008730:Methoxsalen; D014307:Trioxsalen