title: [Clinical view of toxoplasmosis in children--personal observations].
abstract: In this work we presented our own experience with recognized and treated toxoplasmosis among children. Treated cases were observed over several years afterwards. We analyzed the frequency and character of clinical changes, evaluated the validity of serological screening and the effectiveness of treatment. The largest age group treated were children 13 months to 5 years old. 13 children had the congenital and 12 the acquired form. The most cases occurred in the nodal, ocular and ocular-cranial forms. Thus, the most common symptoms were enlarged lymphatic nodes, strabismus, febrile seizures, intracranial calcifications. In the acquired forms of the illness a distinct correlation between treatment and the decrease antibody levels, the clinical pictures showed stagnation. The fall in antibody levels occurred earlier with intermediate immunofluorescence than with ELISA method. Among 20 children associated 30-day treatment was implemented (Daraprim, Rovamycine, Biseptol), among 4 with Fansidar and Rovamycine for 2-3 weeks. Few complications occurred at the end of or after treatment and did not require treatment/intervention. Usually it was leukopenia and thrombocytopenia. Long time observation allows to state that both therapeutic models prevent renewal of illness and can be recommended for further use.
authors.affiliation: Oddziału Dzieciecego Szpitala Miejskiego w Gdyni.
authors.forename: D
authors.initials: D
authors.lastname: Czarnecka-Rudnik
authors.forename: F
authors.initials: F
authors.lastname: Stanek-Bazylko
mesh_terms: D000293:Adolescent; D000890:Anti-Infective Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008403:Mass Screening; D011739:Pyrimethamine / Q000008:administration & dosage; D012698:Serologic Tests; D015572:Spiramycin / Q000008:administration & dosage; D013413:Sulfadoxine / Q000008:administration & dosage; D014123:Toxoplasmosis / Q000175:diagnosis* / Q000188:drug therapy*; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis / Q000628:therapy; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D015572:Spiramycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013413:Sulfadoxine; D011739:Pyrimethamine