title: Liver regulation of acid-base balance.
abstract: Traditionally, lungs and kidneys have been viewed as the sole and principal organs involved in systemic acid-base homeostasis in mammals, but this view is not entirely compatible with basic principles of chemistry. Recent conceptual developments point to a role for the liver in pH homeostasis in addition to the well-established role of lungs and kidneys. Hepatic and renal nitrogen metabolism are linked by an interorgan glutamine flux, which couples both renal ammoniagenesis and hepatic ureogenesis to systemic acid-base regulation. Hepatic urea synthesis is a major pathway for the removal of metabolically generated bicarbonate. A structural-functional organization in the liver acinus uncouples urea cycle flux control from the vital need to maintain ammonium homeostasis. There is a sensitive and complex control of bicarbonate disposal via hepatic ureogenesis by the extracellular acid-base status, suggestive of a feedback control loop between acid-base status and the rate of bicarbonate elimination, i.e., a hepatic bicarbonate-homeostatic response. Some pathophysiological implications arising from the pH-stat function of the liver are discussed.
authors.affiliation: Medizinische Universitätsklinik Freiburg, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Häussinger
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001692:Biological Transport; D005246:Feedback; D006706:Homeostasis; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000502:physiology*; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D001639:Bicarbonates