Let's get specific: the relationship between specificity and affinity.
The factors that lead to high-affinity binding are a good fit between the surfaces of the two molecules in their ground state and charge complementarity. Exactly the same factors give high specificity for a target. We argue that selection for high-affinity binding automatically leads to highly specific binding. This principle can be used to simplify screening approaches aimed at generating useful drugs.
Eaton
B E
BE
NeXstar Pharmaceuticals, Inc., Boulder, CO 80301, USA.
Gold
L
L
Zichi
D A
DA
D000818:Animals; D015195:Drug Design; D006801:Humans; D011485:Protein Binding; D011955:Receptors, Drug / Q000737:chemistry*; D013499:Surface Properties
D011955:Receptors, Drug