title: Enterocytozoon bieneusi in AIDS: symptomatic relief and parasite changes after furazolidone.
abstract: OBJECTIVE
  To investigate changes in morphology of the developmental stages of Enterocytozoon bieneusi and symptomatic relief observed in AIDS patients after treatment with furazolidone.
  
  
  METHODS
  Six AIDS patients with symptomatic E bieneusi infection of the small intestine were treated with a course of furazolidone. All patients had a weekly monitoring of parasite shedding in stool by light microscopy during and after treatment. At the end of the treatment, duodenal biopsy specimens obtained from three patients were studied by transmission electron microscopy by two pathologists who were unaware of the patients' treatment.
  
  
  RESULTS
  All patients showed both clinical and parasitological response with transient clearance or decrease of spore shedding in stool. After treatment, alterations in faecal spores were observed in all patients by light microscopy, and ultrastructural changes in E bieneusi at all stages of the life cycle were demonstrated in biopsy specimens of the three patients who underwent post-treatment endoscopy.
  
  
  CONCLUSIONS
  The clinical benefit seen after treatment with furazolidone in six AIDS patients with E bieneusi intestinal infection may be due to damage to the developmental stages causing a partial inhibition to reproduction of the parasite.
authors.affiliation: Infectious Diseases Unit, Careggi Hospital, Florence, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Dionisio
authors.forename: L I
authors.initials: LI
authors.lastname: Manneschi
authors.forename: S
authors.initials: S
authors.lastname: Di Lollo
authors.forename: A
authors.initials: A
authors.lastname: Orsi
authors.forename: G
authors.initials: G
authors.lastname: Sterrantino
authors.forename: M
authors.initials: M
authors.lastname: Meli
authors.forename: M
authors.initials: M
authors.lastname: Gabbrielli
authors.forename: A
authors.initials: A
authors.lastname: Tani
authors.forename: A
authors.initials: A
authors.lastname: Papucci
authors.forename: F
authors.initials: F
authors.lastname: Leoncini
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005664:Furazolidone / Q000627:therapeutic use*; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D008297:Male; D016816:Microsporida / Q000302:isolation & purification*; D016881:Microsporidiosis / Q000188:drug therapy*; D013170:Spores
chemical_list: D000900:Anti-Bacterial Agents; D005664:Furazolidone