title: Intubating conditions using cisatracurium after induction of anaesthesia with thiopentone.
abstract: We studied tracheal intubation conditions produced by the muscle relaxant, cisatracurium, following induction of anaesthesia with fentanyl (2 micrograms.kg-1) and thiopentone (6 mg.kg-1). Sixty patients were randomly assigned to receive cisatracurium in a single bolus dose of either 0.15 or 0.20 mg.kg-1. Tracheal intubation was commenced 120 s after injection of the relaxant. The mean (SD) time taken to achieve intubation was significantly shorter in the 0.20 mg.kg-1 group (137 (16) s) than the 0.15 mg.kg-1 group (149 (12) s; p < 0.05). The intubating conditions were better after the larger dose. Our results suggest that when anaesthesia is induced using thiopentone, a dose of 0.20 mg.kg-1 of cisatracurium is recommended to ensure satisfactory intubating conditions.
authors.affiliation: Department of Anaesthetics, Henri Mondor Hospital, Creteil, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Rimaniol
authors.forename: Y
authors.initials: Y
authors.lastname: Kersuzan
authors.forename: P
authors.initials: P
authors.lastname: Duvaldestin
mesh_terms: D000328:Adult; D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D001279:Atracurium / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005283:Fentanyl; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D007536:Isomerism; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D013874:Thiopental; D013997:Time Factors
chemical_list: D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; D013874:Thiopental; D005283:Fentanyl