Decreased habituation of midlatency auditory evoked responses in Parkinson's disease.
The P1 midlatency auditory evoked potential was studied in patients with Parkinson's disease and compared to that in age-matched controls. Habituation of the potential was determined by using a two-click stimulus paradigm in which the stimuli were presented at 250-, 500-, and 1,000-ms interstimulus intervals. Results showed that habituation of the P1 potential had a statistically significant decrease at the 250-ms and 500-ms interstimulus intervals in patients with Parkinson's disease compared to normal controls. The degree of decreased habituation was found to increase with severity of the disease such that stage 5 patients showed greater decreases in habituation compared to stage 4, as did stage 4 compared to stage 3. These findings may be explained by the presence of a dysregulation of sensory processing, possibly by elements of the reticular activating system, including the pedunculopontine nucleus, in Parkinson's disease.
Teo
C
C
Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Rasco
L
L
al-Mefty
K
K
Skinner
R D
RD
Boop
F A
FA
Garcia-Rill
E
E
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011619:Psychotropic Drugs / Q000009:adverse effects; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D012720:Severity of Illness Index
D011619:Psychotropic Drugs