title: Successful treatment of disseminated central nervous aspergillosis in a patient with acute myeloblastic leukemia.
abstract: Invasive opportunistic mycoses are common complications in patients suffering from hematological disorders. Brain abscesses in the immunocompromised host are known to be most frequently caused by fungi of the Aspergillus species and are often associated with concomitant pulmonary disease. As the penetration of the currently available antifungal agents into the brain tissue is limited, only very few patients have been described to survive this life-threatening condition. We report the case of a 62 year old female patient who presented with multiple aspergillus brain abscesses during prolonged neutropenia following induction chemotherapy for acute myeloblastic leukemia and was successfully treated with high dose (8 mg/kg/day) liposomal amphotericin B.
authors.affiliation: Department of Hematology/Oncology, University of Freiburg Medical Center, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Mahlknecht
authors.forename: F
authors.initials: F
authors.lastname: von Lintig
authors.forename: R
authors.initials: R
authors.lastname: Mertelsmann
authors.forename: A
authors.initials: A
authors.lastname: Lindemann
authors.forename: M
authors.initials: M
authors.lastname: Lübbert
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy*; D001922:Brain Abscess / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008081:Liposomes; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B