Chiral resolution of flobufen by high performance liquid chromatography and capillary electrophoresis.
The enantiomeric separation of an anti-inflammatory drug flobufen was performed on various chiral columns in liquid chromatography and by reversed phase chromatography and by capillary electrophoresis with beta-cyclodextrin as a chiral selector in the mobile phase and background electrolyte, respectively. The elution order of individual enantiomers is discussed with respect to the absolute chirality of (+/-)-flobufen determined by X-ray crystallography.
Tesarvá
E
E
Department of Analytical Chemistry, Institute of Chemical Technology, Prague, Czech Republic.
Gilar
M
M
Jegorov
A
A
Uhrová
M
M
Deyl
Z
Z
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification*; D002087:Butyrates / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D018360:Crystallography, X-Ray; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods*; D007202:Indicators and Reagents; D013237:Stereoisomerism; D047392:beta-Cyclodextrins
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002087:Butyrates; D003505:Cyclodextrins; D007202:Indicators and Reagents; D047392:beta-Cyclodextrins; C056474:flobufen; C031215:betadex