[Effects of injectio reduqing on plasma IL-8 and nitric oxide levels in rabbits with endotoxin induced disseminated intravascular coagulation].
Experiments were performed for investigating the effects of Injectio Reduqing (RDQ) on plasma interleukin-8 (IL-8), NO2-/NO3-, complement 5a(C5a) and polymorphonuclear neutrophilic leukocyte (PMN) Chemotaxis Index (CI) in rabbits with endotoxin-induced disseminated intravascular coagulation (DIC). The results showed that plasma IL-8, NO2-/NO3-, C5a and CI levels of PMN increased markedly in model group, which were confirmed pathologically with obvious damage of tissues or organs. While in RDQ group the abov-mentioned parameters and damage of tissues or organs were reduced significantly (P < 0.01). The results suggested that the IL-8 and NO might be involved in pathogenesis of endotoxin-induced DIC, and RDQ could be used in preventing or treating DIC through mechanism of regulation of cytokines network.
Yang
G
G
Institute of Integrated Traditional and Western Medicine, Tongji Medical University, Wuhan.
Li
M Z
MZ
Zhang
Y P
YP
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000139:chemically induced / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D016209:Interleukin-8 / Q000097:blood*; D008070:Lipopolysaccharides; D008297:Male; D009504:Neutrophils / Q000502:physiology; D009569:Nitric Oxide / Q000097:blood*; D011817:Rabbits
D004365:Drugs, Chinese Herbal; D016209:Interleukin-8; D008070:Lipopolysaccharides; D009569:Nitric Oxide