[The treated effects of nimodipine on calcium of erythrocyte in experimental hypoxic-ischemic encephalopathy].
An animal model of hypoxic-ischemic encephalopathy (HIE) in newborn pigs was set up to study the histopathological changes of brain injury by light- and electron-microscopy, the changes in total calcium content and calcium iron of RBC, and the effects of two different doses of Nimodipine on HIE. Sixty-one newborn pigs were randomly divided into seven groups, the normal control group (n = 9); the HIE 1-hour group (n = 8) and 24-hour group (n = 8); HIE+ Nimodipine (1 microgram/kg.min-1) 1-hour group (n = 8) and 24-hour group (n = 8). The results showed that these were apparent brain edema, hematencephalon, neuron necrosis, and intracellular body degeneration in the HIE 1-hour group. The levels of RBC TCa and RBC Cai2+ in the HIE 1-hour group were significantly higher than those in the normal control group (P < 0.01). The brain tissues in all groups treated with Nimodipine showed histopathological betterment Compared with the HIE groups. The levels of RBC TCa and RBC Cai2+ in the Nimodipine treatment groups were significantly lower than those in HIE groups (P < 0.01) and were close to the levels in the normal control group (P < 0.05). The authors suggested that early application of Nimodipine in case of postnatal asphyxia might protect the newborn from severe hypoxicischemic brain lesions.
Jiang
J
J
Department of Pediatrics, Second Affiliated Hospital, Chengdu.
Yao
Y
Y
Li
W
W
Mu
D
D
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy*; D002118:Calcium / Q000097:blood*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D000860:Hypoxia / Q000150:complications*; D008297:Male; D009553:Nimodipine / Q000627:therapeutic use*; D011897:Random Allocation; D013552:Swine
D002121:Calcium Channel Blockers; D009553:Nimodipine; D002118:Calcium