Prospects for intravascular gene therapy.
The goal of this review is to provide an overview of gene delivery systems and candidate genes currently being evaluated for genetic strategies in vascular gene therapy. We will discuss treatment strategies that have been shown by in vivo model systems to be efficacious in promoting neovascularization of ischemic tissue or limiting post-interventional restenosis by inhibiting smooth muscle cell proliferation and/or encouraging re-endothelialization.
Smith
R C
RC
Division of Cardiovascular Research, St. Elizabeth's Medical Center, Boston, Massachusetts 02135, USA.
Walsh
K
K
D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D014652:Vascular Diseases / Q000235:genetics* / Q000628:therapy*