Experimental model of neuropathological changes characteristic for Alzheimer's disease.
Data suggest that either proteolytically cleaved fragments of the full-length beta-amyloid precursor protein or the entire beta-amyloid precursor protein molecule are accumulated extracellularly and intracellularly in rat brain after cardiac arrest with survival time from 3 hours to 12 months. Direct evidence that precursors for fragments of the full-length beta-amyloid precursor protein can cross the blood-brain barrier and enter the brain parenchyma from the circulation is provided for the first time.
Pluta
R
R
Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warszawa.
D000544:Alzheimer Disease / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000032:analysis; D000818:Animals; D001057:Apolipoproteins E / Q000032:analysis; D001812:Blood-Brain Barrier; D002545:Brain Ischemia / Q000473:pathology; D002199:Capillary Permeability; D004195:Disease Models, Animal; D005260:Female; D051381:Rats; D017208:Rats, Wistar
D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E