title: Analytical methodology for biological monitoring of chromium.
abstract: Analytical aspects associated with biological and ambient monitoring are outlined with an emphasis on processing samples at very low concentrations and optimization of analytical methods. Verification of chromium determination in body fluids by means of "Round Robin" tests is discussed. In addition, an approach for indirect valency discrimination of chromium species relevant in biological monitoring is presented. Application of voltammetry for model tests is described. This is aimed at studying the reaction of hexavalent chromium in human plasma. As a result, a natural reducing capacity of plasma of up to 2 ppm chromium(VI) was detected and quantified as an individual biological index. Furthermore, the effect of ascorbic acid on the reduction of chromium(VI) in plasma is demonstrated and quantitative bases for therapy in cases of accidental intoxication are discussed.
authors.affiliation: Business Group Inorganics, Bayer AG, Leverkusen, D-51368, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Harzdorf
authors.forename: J
authors.initials: J
authors.lastname: Lewalter
mesh_terms: D000818:Animals; D002857:Chromium / Q000032:analysis*; D017608:Chromium Compounds / Q000032:analysis*; D004784:Environmental Monitoring / Q000295:instrumentation / Q000379:methods*; D006801:Humans
chemical_list: D017608:Chromium Compounds; D002857:Chromium