[A case-control study of childhood leukemia].
A 1:1 matched case-control study was conducted to investigate the etiological factors of childhood leukemia. It was found that there were five risk factors: (1) children living in the environmental pollution area, OR (95% CI) = 2.84 (1.14-7.10); (2) exposure to extreme low frequency electronmagnetic field (ELF), OR (95% CI) = 2.01 (1.18-3.42); (3) history of postnatal X-ray exposure, OR (95% CI) = 4.53 (1.68-12.21); (4) history of taking chloramphenicol, OR (95% CI) = 3.60 (1.62-8.01); (5) history of taking, antipyretic or analgesic drugs, OR (95% CI) = 1.93 (1.09-3.42). A protective factor was also discovered. Mothers often eating fish, pork and other meat foods, OR (95% CI) = 0.33 (0.18-0.59). The analysis of the population attributable risk showed that 91% of the childhood leukemia cases might attribute to these five risk factors. The interaction among these etiological factors was estimated. Results showed that there was a positive interaction between the X-ray exposure and chloramphenicol on additive model, the relative excess risk due to interaction (RERI) of childhood leukemia was 3.04.
Lu
J C
JC
Guangzhou Medical College.
Shi
L Y
LY
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D002701:Chloramphenicol / Q000009:adverse effects; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000209:etiology; D016015:Logistic Models; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D012494:Sampling Studies; D014965:X-Rays / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D002701:Chloramphenicol