title: Wegener's granulomatosis and ANCA syndromes.
abstract: The nervous system is involved in approximately 25% of patients with classical Wegener's granulomatosis. The spectrum of this disease has been broadened with the discovery of the anti-neutrophil cytoplasmic antibodies, which are found in diseases sharing many clinical features. The ANCA testing may indicate a common mode of pathogenesis. The definitive diagnostic marker is histological, and that forms the best guide to specific therapy.
authors.affiliation: Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
authors.forename: I A
authors.initials: IA
authors.lastname: Jaffe
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000477:Alkylating Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D011379:Prognosis; D012008:Recurrence; D013420:Sulfamethoxazole / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000477:Alkylating Agents; D000890:Anti-Infective Agents; D019268:Antibodies, Antineutrophil Cytoplasmic; D000964:Antimetabolites, Antineoplastic; D003520:Cyclophosphamide; D013420:Sulfamethoxazole; D008727:Methotrexate