title: In-vitro photobactericidal activity of aminoacridines.
abstract: The toxicities of several aminoacridines were measured against pathogenic strains of both Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) organisms. In several cases, illumination at a light dose of 6.3 J/cm2 resulted in considerable decreases in the minimum lethal drug concentrations required, giving up to 50-fold increases in bactericidal activity. Derivatives of 9-aminoacridine (aminacrine) exhibited phototoxicity against one or more of the test organisms, but the established photosensitizing acridines proflavine and acridine orange were photobactericidal against all strains.
authors.affiliation: Department of Chemistry, University of Central Lancashire, Preston, UK. m.wainwright@uclan.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Wainwright
authors.forename: D A
authors.initials: DA
authors.lastname: Phoenix
authors.forename: J
authors.initials: J
authors.lastname: Marland
authors.forename: D R
authors.initials: DR
authors.lastname: Wareing
authors.forename: F J
authors.initials: FJ
authors.lastname: Bolton
mesh_terms: D000609:Aminoacridines / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008027:Light; D017319:Photosensitizing Agents / Q000494:pharmacology*
chemical_list: D000609:Aminoacridines; D017319:Photosensitizing Agents