title: Insulinoma: a review of current management.
abstract: Insulinomas are a relatively rare tumour which occur predominantly in the pancreas. The majority of the tumours are benign, but have profound effects upon the patient. The diagnosis of insulinoma is often elusive, and the management may involve demanding surgery with a significant morbidity. In this review article, all clinical aspects of insulinomas are examined. Particular emphasis is placed on the myriad modes of presentation, and the methods used to localise the tumour pre-operatively. Medical, as well as surgical treatments are discussed and their role in the management of both malignant and benign tumours. Despite potential difficulties encountered in managing patients with this tumour, a large majority may be either cured or achieve useful palliation.
authors.affiliation: Department of Surgery, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
authors.forename: R D
authors.initials: RD
authors.lastname: Bliss
authors.forename: P B
authors.initials: PB
authors.lastname: Carter
authors.forename: T W
authors.initials: TW
authors.lastname: Lennard
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D011379:Prognosis; D015996:Survival Rate