title: [The value of CA125 and LDH assays in assisting diagnosis of epithelial ovarian carcinoma].
abstract: 40 first-treated cases of epithelial ovarian cancer, 13 cases of cervical cancer, 13 cases of corpus cancer and 50 cases of benign tumor were included in this study from Jan. 1991 through May 1992 to evaluate the significance of the blood CA125, LDH, CR and SA levels in assisting diagnosis of epithelical ovarian cancer. The CA125 levels of the 40 canses of ovarian cancer were higher than those of cervical cancer and corpus cancer (P < 0.05); the SS, PLR and AC of CA125 in ovarian cancer were higher than those of LDH, SA and CR (P < 0.05); the SS of CA125 in ovarian cancer was higher than that of LDH isoenzyme (P < 0.05). The results show that CA125 may be the best tumor marker in assisting ovarian cancer; CA125 is more informative than LDH, CR and SA; when CA125 is used incombination with other tumor markers, SS, SP, NPV and PPV can be greatly raised.
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chengdu.
authors.forename: M
authors.initials: M
authors.lastname: Qie
authors.forename: Z
authors.initials: Z
authors.lastname: Peng
authors.forename: Z
authors.initials: Z
authors.lastname: Cao
authors.forename: Q
authors.initials: Q
authors.lastname: Tang
authors.forename: B
authors.initials: B
authors.lastname: He
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D018394:CA-125 Antigen / Q000032:analysis*; D002277:Carcinoma / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase