[Mechanism of the induction of apoptosis by influenza virus infection].
Influenza virus-infected HeLa cells show phosphatidylserine externalization, chromatin condensation, increase of membrane permeability, and inactivation of a mitochondrial enzyme(s), which are collectively referred as apoptosis. The amount of cell surface Fas and its ligand increases before the onset of apoptosis and the presence of a Fas-ligand-antagonizing antibody inhibits apoptosis. Since virus-infected cells simultaneously express Fas and Fas-ligand, it is likely that apoptosis is induced when the cells come into contact with each other. We expect that apoptotic death of influenza virus-infected cells contributes to elimination of the virus from host organism.
Matsumura
M
M
Faculty of Pharmaceutical Sciences, Kanazawa University.
Nakanishi
Y
Y
D017209:Apoptosis / Q000502:physiology*; D002478:Cells, Cultured; D006801:Humans; D007251:Influenza, Human / Q000276:immunology / Q000821:virology*; D008024:Ligands; D019014:fas Receptor / Q000235:genetics / Q000502:physiology
D008024:Ligands; D019014:fas Receptor