title: Functional organization of cotransmission systems: lessons from small nervous systems.
abstract: Small invertebrate nervous systems allow one to ask a series of questions concerning the functional roles of cotransmitters. This review outlines some of the implications of cotransmission for target selectivity in complex neuropils. We suggest the possibility that a unique constellation of cotransmitters in individual identified modulatory neurons allows a specificity of action even when peptides may act over an extended distance, and when individual modulatory substances may be released from several modulatory neurons.
authors.affiliation: Volen Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA.
authors.forename: E
authors.initials: E
authors.lastname: Marder
authors.forename: A E
authors.initials: AE
authors.lastname: Christie
authors.forename: V L
authors.initials: VL
authors.lastname: Kilman
mesh_terms: D000818:Animals; D007448:Invertebrates / Q000502:physiology*; D009424:Nervous System Physiological Phenomena; D018377:Neurotransmitter Agents / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D014018:Tissue Distribution
chemical_list: D018377:Neurotransmitter Agents