Transdermal iontophoresis of salmon calcitonin can reproduce the hypocalcemic effect of intravenous administration.
Salmon calcitonin (sCt) was administered by transdermal iontophoresis in rabbits, using a new drug reservoir assembled directly on the skin, based on a dry disc containing sCt to be dissolved at the application site. The hypocalcemic effect was taken as a measure of the pharmacodynamic response. In rabbits, the results obtained show that salmon calcitonin skin penetration by iontophoresis, using pulsatile current of 0.8 mA/cm2 on a reservoir containing 100 IU/Kg of sCt, was governed by the quantity of electric charge applied, mimicking the hypocalcemic response of 10 IU/Kg intravenous administration.
Santi
P
P
Dipartimento Farmaceutico, Università di Parma, Italy.
Volpato
N M
NM
Bettini
R
R
Catellani
P L
PL
Massimo
G
G
Colombo
P
P
D000279:Administration, Cutaneous; D000818:Animals; D002116:Calcitonin / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000494:pharmacology; D002118:Calcium / Q000097:blood; D006996:Hypocalcemia / Q000139:chemically induced*; D007478:Iontophoresis; D011817:Rabbits; D012474:Salmon
C028815:salmon calcitonin; D002116:Calcitonin; D002118:Calcium