[G-CSF and all-trans retinoic acid-induced leukocytosis].
During the treatment with all-trans retinoic acid (ATRA) for acute promyelocytic leukemia (APL), leukocytosis occured in 33%-75% of the treated cases. ELISA method was used in detecting levels of serum granulocyle colony-stimulating factor (G-CSF) in 47 cases of APL during treatment with ATRA. It was found that the peak of increased serum G-CSF level occurred on the 9th day, and WBC number was highest on the 11th day. After ATRA treatment, both serum G-CSF level and WBC number increased in 68.1% of the cases. In 19.2% of the cases treated, serum G-CSF level was increased but without obvious change in WBC number, and the reverse was true in 12.7% of the cases. Serum G-CSF level was statistically correlated to the number of WBC, promyelocytes and its late stage by Spearman rank correlation analysis.
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Shanghai Second Medical University Shanghai Ruijin Hospital, Laborotory of Cellularbiology, Shanghai Institute of Hematology.
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000188:drug therapy*; D007958:Leukocyte Count; D007964:Leukocytosis / Q000097:blood / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D014212:Tretinoin / Q000009:adverse effects*
D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor; D014212:Tretinoin