title: Differential effects of aging on NADPH-diaphorase and VIP neurons in cerebral cortex of rats.
abstract: Age-related changes of NADPH-diaphorase (NADPH-d) and vasoactive intestinal polypeptide (VIP) were examined in the rat brain. Aged (24 months) rats showed a significant decrease in the number of VIP-immunoreactive (IR) neurons in the cerebral cortex when compared with control (4 months) rats. However, the number of NADPH-d-positive neurons was not significantly different in the two groups. Quantitative analysis of cell areas revealed a significant shrinkage of VIP-IR neurons in the aged group, whereas no further cell shrinkage was noted for NADPH-d-positive neurons compared with the control group. These morphometric results demonstrate that NADPH-d-containing neurons are more resistant to aging than the VIP-IR neurons in the cerebral cortex of rats.
authors.affiliation: Department of Anatomy, College of Medicine, Kyunghee University, Seoul, South Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Huh
authors.forename: C
authors.initials: C
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Cho
authors.forename: W
authors.initials: W
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Ahn
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002452:Cell Count; D048429:Cell Size; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
chemical_list: D014660:Vasoactive Intestinal Peptide; D009252:NADPH Dehydrogenase