[Morphological studies of the adrenal zona glomerulosa cells and the thyroid and pituitary glands in streptozocin-induced experimental diabetic rats].
Changes in pathological morphology in the adrenal glomerulosa, the thyroid and pituitary glands in streptozotocin-induced experimental diabetic rats were studied by histologic, ultrastructural examination and morphometry. Experimental diabetes provoked atrophy and retrograde degeneration of organelles in the adrenal zona glomerulosa cells and the thyroid follicular epithelium. In the pituitary of diabetic rats, organelles in thyrotrophs were the same as the controls in morphometry, but TSH release was impaired. These studies indicate that pathological changes in the zone glomerulsa cells and the thyroid of diabetic rats appear to be responsible for the impaired function of these two glands. Moreover, reduced TSH release in the pituitary glands is also associated with impaired function of the thyroid gland.
Liu
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Department of Internal Medicine, First Affiliated Hospital, Chongqing University of Medical Sciences.
Shu
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D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000648:ultrastructure*; D013972:Thyrotropin / Q000378:metabolism; D015384:Zona Glomerulosa / Q000648:ultrastructure*
D013972:Thyrotropin