Recombination initiation: easy as A, B, C, D... chi?
The octameric Chi (chi) sequence is a recombination hotspot in Escherichia coli. Recent studies suggest a singular mechanism by which chi regulates not only the nuclease activity of RecBCD enzyme, but also the ability of RecBCD to promote loading of the strand exchange protein, RecA, onto chi-containing DNA.
Eggleston
A K
AK
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK.
West
S C
SC
D001665:Binding Sites; D004269:DNA, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D043211:Exodeoxyribonuclease V; D005090:Exodeoxyribonucleases / Q000378:metabolism*; D009154:Mutation; D011938:Rec A Recombinases / Q000378:metabolism*; D011995:Recombination, Genetic
D004269:DNA, Bacterial; D011938:Rec A Recombinases; D005090:Exodeoxyribonucleases; D043211:Exodeoxyribonuclease V