title: Combined effects of a simultaneous exposure to noise and toluene on hearing function.
abstract: To study the combined effects of noise and toluene on auditory function, three experimental groups of Long-Evans adult rats were used. The first group was exposed to toluene (2000 ppm, 6 h/day, 5 days/week, 4 weeks), the second group to an octave band of noise centered at 8 kHz (92 dB SPL), and the last group to a simultaneous exposure to toluene and noise. Auditory function was tested by recording brainstem (inferior colliculus) auditory-evoked potentials. The auditory deficit induced by the combined exposure exceeded the summated losses caused by toluene alone and by noise alone within the range (2-32 kHz) of test frequencies. The nature of the cochlear damage induced by noise alone (injured stereocilia) or by toluene alone (outer hair cells loss) is different.
authors.affiliation: Institut National de Recherche et de Sécurité (I.N.R.S.), Vandoeuvre, France.
authors.forename: R
authors.initials: R
authors.lastname: Lataye
authors.forename: P
authors.initials: P
authors.lastname: Campo
mesh_terms: D000818:Animals; D001299:Audiometry; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology; D003051:Cochlea / Q000473:pathology / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000502:physiology; D006317:Hearing Loss, Noise-Induced / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology*; D007245:Inferior Colliculi / Q000473:pathology / Q000503:physiopathology; D019570:Inhalation Exposure; D008297:Male; D008855:Microscopy, Electron, Scanning; D009622:Noise / Q000009:adverse effects*; D051381:Rats; D014050:Toluene / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D014050:Toluene