A novel adipocyte long chain fatty acid transport protein.
Uptake of long chain fatty acids (LCFAs) is a critical function of eukaryotic cells. In the past, a diffusional mechanism has been proposed for passage of these hydrophobic molecules across the plasma membrane. I have recently used an expression cloning strategy to identify a novel integral plasma membrane fatty acid transport protein (FATP), which functions as an LCFA transporter. FATP may play a pivotal role in alterations of cellular metabolism which occur in several pathophysiologic states.
Schaffer
J E
JE
Washington University School of Medicine, 660 South Euclid Avenue, Box 8086, St. Louis, MO 63110, USA.
D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D050612:Fatty Acid Transport Proteins; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins
D002352:Carrier Proteins; D050612:Fatty Acid Transport Proteins; D005227:Fatty Acids; D008565:Membrane Proteins; D026901:Membrane Transport Proteins