title: Cocaine dependence. A clinical syndrome requiring neuroprotection.
abstract: Cocaine use has increased the frequency of medical complications among younger individuals. Neurological and neurovascular complications include strokes, seizures, transient ischemic attacks, and headaches. Subclinical deficits in cerebral perfusion and EEG have been noted in this population. Although these subclinical deficits may be an indication of increased risk of medical complications, the prophalactic treatment of cocaine abusers with neuroprotective agents has not yet been advocated. Blood flow of the anterior and medial cerebral arteries was measured by transcranial Doppler sonography in cocaine abusers (n = 70) and control subjects (n = 20) to determine whether cocaine abusers might have reduced cerebral blood flow in large cerebral arteries. Blood flow was measured within three days of and again about 28 days after admission of subjects to an inpatient research ward to determine whether blood flow improved with monitored abstinence. The mean, systolic, and diastolic velocities as well as the Pulsatility Index (PI) in both arteries differed between the control and cocaine abusers (p < 0.05). After about a month of abstinence, blood flow for the cocaine-dependent subjects increased. These preliminary findings suggest that blood flow is reduced in cocaine abusers and that there is a slight improvement with abstinence. Further research is needed to determine whether blood flow in abstinent cocaine abusers can be increased by pharmacological manipulations.
authors.affiliation: Molecular Neuropsychiatry Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA.
authors.forename: R I
authors.initials: RI
authors.lastname: Herning
authors.forename: D E
authors.initials: DE
authors.lastname: King
authors.forename: W
authors.initials: W
authors.lastname: Better
authors.forename: J L
authors.initials: JL
authors.lastname: Cadet
mesh_terms: D000328:Adult; D002536:Cerebral Arteries / Q000502:physiology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D003042:Cocaine; D003710:Demography; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D011674:Pulse; D012016:Reference Values; D012039:Regional Blood Flow; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013577:Syndrome; D013599:Systole; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D003042:Cocaine