Excitotoxic lesions of the prefrontal cortex reduce dopamine D1-like receptors in the ventral tegmental area.
Ventral mesencephalic dopamine D1-like receptors were quantified in brains of male rats ten days after unilateral microinjections of ibotenic acid (2 or 10 microg/microl) or its vehicle into the medial prefrontal cortex. The density of dopamine D1-like receptors was reduced by more than 40% in the ipsilateral ventral tegmental area (both doses) and by 15% (low dose) and 44% (high dose) in the contralateral side; no significant reduction was observed in the substantia nigra. These results suggest that a significant number of ventral tegmental D1-like receptors are localized on afferent terminals from the medial prefrontal cortex.
Dewar
K M
KM
Centre de recherche Fernand-Seguin, Hôpital Louis-H. Lafontaine, Montreal, Québec, Canada. dewark@ere.umontreal.ca
Rompré
P P
PP
Stewart
J
J
Warren
R A
RA
D000818:Animals; D001345:Autoradiography; D018690:Excitatory Amino Acid Agonists; D007839:Functional Laterality; D007051:Ibotenic Acid; D007276:Injections, Intraventricular; D008297:Male; D017397:Prefrontal Cortex / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism; D017557:Ventral Tegmental Area / Q000378:metabolism*
D018690:Excitatory Amino Acid Agonists; D017447:Receptors, Dopamine D1; D007051:Ibotenic Acid