title: Basaloid-squamous cell carcinoma of the floor of the mouth: characterization of a cell line.
abstract: Since it was first described in 1986, basaloid-squamous cell carcinoma (BSC) has been considered a distinct variant of squamous cell carcinoma that occurs in a variety of anatomic sites, including the head and neck region. We report the characterization of the first cell line established from a basaloid-squamous cell carcinoma of the floor of the mouth. The cell line exhibited a highly invasive capacity, indicating that BSC has very aggressive behavior. This cell line may be a useful model for elucidation of the biological characteristics of BSC.
authors.affiliation: Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Abiko
authors.forename: K
authors.initials: K
authors.lastname: Okumura
authors.forename: T
authors.initials: T
authors.lastname: Ohuchi
authors.forename: T
authors.initials: T
authors.lastname: Konishi
authors.forename: M
authors.initials: M
authors.lastname: Kanazawa
authors.forename: T
authors.initials: T
authors.lastname: Kaku
mesh_terms: D000199:Actins / Q000032:analysis; D001695:Biology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D002455:Cell Division; D002465:Cell Movement; D002469:Cell Separation; D003470:Culture Media; D004727:Endothelium / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor / Q000473:pathology*; D009062:Mouth Neoplasms / Q000473:pathology*; D018396:Mucin-1 / Q000032:analysis; D009361:Neoplasm Invasiveness; D009418:S100 Proteins / Q000032:analysis; D014062:Tongue Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
chemical_list: D000199:Actins; D003470:Culture Media; D018396:Mucin-1; D009418:S100 Proteins; D007633:Keratins