Comparative aspects of chloride-dependent amino acid transport across the brush-border membrane of mammalian small intestine.
Chloride-dependent amino acid transport has been described in several tissues. This article briefly reviews the evidence of cotransport of chloride and amino acids across the brush-border membrane of rabbit distal ileum. On the basis of amino acid carriers described in the rabbit and the surveys of chloride-dependence reported, a comparison of amino acid carriers in the mammalian small intestine is performed. Additional characteristics of the carriers in the different species are included in the discussion when necessary. From this comparison the rabbit distal ileum and the pig small intestine emerge as the best models of amino acid transport in the human small intestine.
Munck
L K
LK
Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark.
D000596:Amino Acids / Q000493:pharmacokinetics*; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002712:Chlorides / Q000502:physiology*; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism* / Q000648:ultrastructure; D008322:Mammals / Q000378:metabolism*; D008871:Microvilli / Q000378:metabolism
D000596:Amino Acids; D002712:Chlorides