Clinical drug photosensitivity. A retrospective analysis of reports to the Norwegian Adverse Drug Reactions Committee from the years 1970-1994.
Adverse drug reactions reported to the Norwegian Medicine Control Authority from 1970 to 1994 were analyzed, especially with regard to cutaneous reactions and photosensitization. In the time period, almost 13,000 unwanted side effects were reported. Of these, 799 reports involved the skin and appendages, of which 64 reports (8%) were classified as photosensitivity reactions. Tetracyclines, diuretics, antihypertensive agents, and urologicals were the drugs that most often caused photosensitivity reactions. In addition, a number of uncommon photosensitizing drugs were reported. The risk for photosensitization is discussed on the basis of experimental data and the prescription rates of these substance.
Selvaag
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Department of Dermatology, Ullevaal Hospital, University of Oslo, Norway.
D016907:Adverse Drug Reaction Reporting Systems; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000009:adverse effects; D004232:Diuretics / Q000009:adverse effects; D003875:Drug Eruptions / Q000453:epidemiology; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D006801:Humans; D009664:Norway; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D013754:Tetracyclines
D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D000959:Antihypertensive Agents; D004232:Diuretics; D013754:Tetracyclines