Ifosfamide-induced alteration of technetium-99m-DMSA renal parenchymal imaging.
Renal cortical imaging with 99mTc-dimercaptosuccinic acid (DMSA) has become the imaging test of choice for the diagnosis of acute pyelonephritis. An unusual uptake pattern was observed in a child receiving chemotherapy for a bladder rhabdomyosarcoma. Chemotherapy from ifosfamide produces a specific pattern of injury to the renal tubule that alters uptake of DMSA.
Morrison
S C
SC
Department of Radiology, University Hospitals of Cleveland, Ohio, USA.
O'Donnell
J K
JK
D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects*; D007223:Infant; D007674:Kidney Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D007684:Kidney Tubules / Q000187:drug effects*; D011704:Pyelonephritis / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D018233:Rhabdomyosarcoma, Embryonal / Q000188:drug therapy; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D018906:Antineoplastic Agents, Alkylating; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D007069:Ifosfamide