title: Effect of muscular exercise on the concentration of uridine and purine bases in plasma--adenosine triphosphate consumption-induced pyrimidine degradation.
abstract: To identify whether muscular exercise increases the plasma concentration of uridine and of purine bases, the effect of rigorous muscular exercise was determined in five healthy men with a bicycle ergometer. Twenty-five-minute muscular exercise at 65% maximum O2 consumption increased the concentration of uridine, purine bases, and inorganicphosphate in plasma and of NH3 and lactic acid in blood. These results suggest that exercise-induced excessive adenosine triphosphate (ATP) consumption enhanced not only purine degradation but also pyrimidine degradation (uridine triphosphate [UTP]-->uridine diphosphate [UDP]-->uridine monophosphate [UMP]-->uridine) in exercising muscles.
authors.affiliation: Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Moriwaki
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: Z
authors.initials: Z
authors.lastname: Tsutsumi
authors.forename: J
authors.initials: J
authors.lastname: Yamakita
authors.forename: K
authors.initials: K
authors.lastname: Higashino
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000641:Ammonia / Q000097:blood / Q000378:metabolism; D001784:Blood Gas Analysis; D015444:Exercise / Q000502:physiology*; D006801:Humans; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000097:blood / Q000378:metabolism; D011687:Purines / Q000097:blood* / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism*; D014529:Uridine / Q000097:blood* / Q000378:metabolism
chemical_list: D010710:Phosphates; D011687:Purines; D011743:Pyrimidines; D019344:Lactic Acid; D000641:Ammonia; D000255:Adenosine Triphosphate; D014529:Uridine