Tyrosine phosphorylation of the herpes simplex virus type 1 regulatory protein ICP22 and a cellular protein which shares antigenic determinants with ICP22.
At least eight herpes simplex virus type 1 (HSV-1) and five HSV-2 proteins were tyrosine phosphorylated in infected cells. The first viral tyrosine phosphoprotein identified was the HSV-1 regulatory protein ICP22. Also, two novel phosphotyrosine proteins were bound by anti-ICP22 antibodies. H(R22) is a cellular protein, while the F(R10) protein is observed only in HSV-1-infected cells.
Blaho
J A
JA
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA. blaho@msvax.mssm.edu
Zong
C S
CS
Mortimer
K A
KA
D016475:3T3 Cells; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology; D002522:Chlorocebus aethiops; D000939:Epitopes / Q000276:immunology*; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000276:immunology* / Q000378:metabolism; D018258:Herpesvirus 2, Human / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D010750:Phosphoproteins / Q000276:immunology*; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000276:immunology; D011817:Rabbits; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000276:immunology; D014443:Tyrosine / Q000378:metabolism*; D014709:Vero Cells; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins
D000914:Antibodies, Viral; D000939:Epitopes; C057294:ICP22 protein, human herpesvirus 1; D017874:Immediate-Early Proteins; D010750:Phosphoproteins; D011993:Recombinant Fusion Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C078424:EUS1 protein, Equine herpesvirus 1; D019000:Phosphotyrosine; D014443:Tyrosine