Sustained diurnal blood pressure reduction in SHR with ramipril assessed by telemetric monitoring.
Subchronic bolus administration of the angiotensin-converting-enzyme inhibitor ramipril caused a dose-dependent (0.1 to 10 mg.kg-1.d-1), yet each in his own way 24-hour sustained, reduction in arterial blood pressure in conscious unrestrained spontaneously hypertensive rats with telemetric recording, and 0.01 mg.kg-1.d-1 was a no-effect dose. This was accompanied by dose-dependent attenuation of heart rate lowering during periods of low locomotor activity. Neither effect persisted for more than a few days after cessation of the medication with full restoration of pretreatment levels. No dosage altered the circadian rhythm of blood pressure, heart rate and locomotor activity of the rats.
Becker
R H
RH
Hoechst Marion Roussel DG Cardiovascular, Frankfurt/Main, Germany.
Baldes
L
L
Fürst
U
U
Schulze
K J
KJ
D000704:Analysis of Variance; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D005069:Evaluation Studies as Topic; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017257:Ramipril / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D011918:Rats, Inbred SHR; D012084:Renin-Angiotensin System / Q000187:drug effects; D013686:Telemetry
D000959:Antihypertensive Agents; D017257:Ramipril