[Soluble interleukin-2 receptor in patients with urinary bladder cancer].
Soluble interleukin-2 receptor (sIL-2R) levels in the serum and the effect of the sIL-2R on the natural killer cell factor (NKCF) activity were studied in 31 patients with transitional cell cancer of the urinary bladder. The results showed that serum levels of sIL-2R in the patients were significantly higher than those of controls. sIL-2R level correlated with the stage of the disease. Furthermore, sIL-2R was able to suppress NKCF activity. The results suggest that the sIL-2R may reflect the status of anti-tumor immunity.
Wen
R
R
Department of Urology, Affiliated Hospital of Xuzhou Medical College.
Xie
S
S
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D018664:Interleukin-12 / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015375:Receptors, Interleukin-2 / Q000097:blood*; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000473:pathology
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D018664:Interleukin-12