Genetics of stroke.
Stroke is a very common cause of death and disability. Several lines of evidence point to stroke as a polygenic multifactoral phenotype and there are also a number of well studied single gene Mendelian stroke conditions. Rat models have identified several chromosomal sites linked to stroke, and this together with other background information provides a strategy for both cross-sectional and gene scanning approach to defining the genetics of human stroke.
Carter
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Medical Genetics Unit, St George's Hospital Medical School, London, UK.
D000818:Animals; D002561:Cerebrovascular Disorders / Q000235:genetics*; D006801:Humans; D051381:Rats