title: Hydrogels in endovascular embolization. VI. Toxicity tests of poly(2-hydroxyethyl methacrylate) particles on cell cultures.
abstract: Cytotoxicity of poly(2-hydroxyethyl methacrylate) [poly(HEMA)] hydrogel spherical particles, prepared by radical suspension polymerization and designed for endovascular occlusion, was studied in vitro on cell cultures. Testing methods included a direct contact test and extraction test. No inhibition of growth of cells surrounding the poly(HEMA) beads and a very low inhibition of cell viability, only in concentrated extracts in long-term contact, were observed. As a result, poly(HEMA) beads can be considered non-toxic.
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
authors.forename: D
authors.initials: D
authors.lastname: Horák
authors.forename: M
authors.initials: M
authors.lastname: Cervinka
authors.forename: V
authors.initials: V
authors.lastname: Půza
mesh_terms: D001672:Biocompatible Materials / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D011102:Polyhydroxyethyl Methacrylate / Q000633:toxicity*
chemical_list: D001672:Biocompatible Materials; D011102:Polyhydroxyethyl Methacrylate