Site-specific recombination in plane view.
Biochemists have worked long and hard on each reaction component and chemical step to reach the point of asking the question as to how protein and DNA molecules are arranged and rearranged in the process of site-specific recombination. The structures of several lambda integrase family members published recently have answered many of the questions about this process.
Yang
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W
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, 9000 Rockville Pike, Building 5, Rm B1-03, Bethesda, MD 20892, USA. Wei.Yang@nih.gov
Mizuuchi
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K
D000595:Amino Acid Sequence; D010582:Bacteriophage lambda / Q000201:enzymology; D001665:Binding Sites; D004254:DNA Nucleotidyltransferases / Q000737:chemistry / Q000378:metabolism; D019426:Integrases / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D045522:Recombinases; D011995:Recombination, Genetic; D014764:Viral Proteins
D045522:Recombinases; D014764:Viral Proteins; C045073:Cre recombinase; D004254:DNA Nucleotidyltransferases; D019426:Integrases; C115006:integron integrase IntI1