title: CD3-CD4+ cells with a Th2-like pattern of cytokine production in the peripheral blood of a patient with cutaneous T cell lymphoma.
abstract: A case of cutaneous T cell lymphoma associated with mild eosinophilia and rise of IgE levels is reported. A population of CD3-CD4+ cells was observed in the peripheral blood. After activation, these purified CD3-CD4+ cells showed a Th2 pattern of cytokine production, secreting higher levels of IL-5 and IL-4 and lower levels of IFN-gamma compared to the patient's and controls' CD3+CD4+ cells. Moreover, high levels of IL-5 and soluble CD30, a marker of Th2 cell activation, were detected in the patient's serum.
authors.affiliation: Servizio di Immunologia Clinica, Spedali Civili, Brescia, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Brugnoni
authors.forename: P
authors.initials: P
authors.lastname: Airò
authors.forename: C
authors.initials: C
authors.lastname: Tosoni
authors.forename: M
authors.initials: M
authors.lastname: Taglietti
authors.forename: F
authors.initials: F
authors.lastname: Lodi-Rizzini
authors.forename: P
authors.initials: P
authors.lastname: Calzavara-Pinton
authors.forename: C
authors.initials: C
authors.lastname: Leali
authors.forename: R
authors.initials: R
authors.lastname: Cattaneo
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D016410:Lymphoma, T-Cell, Cutaneous / Q000097:blood*; D008875:Middle Aged; D018418:Th2 Cells
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines; D007376:Interleukin-2; D015848:Interleukin-5; D015847:Interleukin-4; D007371:Interferon-gamma