title: The effect of alpha-trinositol on cholera toxin-induced fluid accumulation in pig (Sus scrofa domesticus) jejunum in vivo.
abstract: The effect of alpha-trinositol (D-myo-inositol-1,2,6-trisphosphate) on cholera toxin-induced fluid accumulation (i.e., net fluid secretion) was studied in the pig jejunum in vivo. Cholera toxin caused a dose-dependent fluid accumulation in control experiments. Intravenous injection of alpha-trinositol produced a reduction of the response to cholera toxin with a significant maximal inhibition of 36%. However, in high concentrations of alpha-trinositol this inhibition was absent.
authors.affiliation: Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
authors.forename: T T
authors.initials: TT
authors.lastname: Tindholdt
authors.forename: M B
authors.initials: MB
authors.lastname: Hansen
authors.forename: V S
authors.initials: VS
authors.lastname: Elbrønd
authors.forename: M
authors.initials: M
authors.lastname: Makinde
authors.forename: E J
authors.initials: EJ
authors.lastname: Westerberg
authors.forename: E
authors.initials: E
authors.lastname: Skadhauge
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001826:Body Fluids / Q000378:metabolism*; D002772:Cholera Toxin / Q000037:antagonists & inhibitors*; D005260:Female; D007295:Inositol Phosphates / Q000494:pharmacology*; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism; D008954:Models, Biological; D013552:Swine / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007295:Inositol Phosphates; D002772:Cholera Toxin; C059368:atrinositol