Sialadenitis in IQI/Jic mice: a new animal model of Sjögren's syndrome.
Focal infiltration of lymphocytes with parenchymal destruction was noted in both salivary and lacrimal glands of IQI/Jic mice. The sialadenitis was found in more than 80% of female mice at all ages examined. The lesion progressed after 6 months and became more prominent with age. In contrast, male mice had slight and stable salivary lesions independent of age, though the incidence increased with age. Infiltrating lymphocytes consisted of both T and B cells. The dominant lymphocytes in small foci were CD4+ cells, but the majority of infiltrating cells were B cells (B220+), followed by CD4+ T cells in larger lesions. The ductual epithelium in the foci aberrantly expressed MHC class II antigen. Eight of 24 15-month-old female mice with sialadenitis produced speckled-type IgG antinuclear autoantibody. These findings are similar to those in patients with Sjögren's syndrome. IQI/Jic mice could be a novel animal model of Sjören's syndrome.
Saegusa
J
J
Laboratory of Experimental Toxicology, National Institute of Industrial Health, Kawasaki, Japan.
Kubota
H
H
D000375:Aging / Q000473:pathology; D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D015704:CD4 Antigens / Q000032:analysis; D002465:Cell Movement / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry / Q000379:methods / Q000662:veterinary; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007765:Lacrimal Apparatus / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012469:Salivary Glands / Q000276:immunology / Q000473:pathology; D012720:Severity of Illness Index; D012727:Sex Characteristics; D012793:Sialadenitis / Q000276:immunology / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000276:immunology / Q000473:pathology*; D013047:Specific Pathogen-Free Organisms; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D000974:Antibodies, Antinuclear; D015704:CD4 Antigens; D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G