[A study on changes and its mechanisms of intestinal mucosal permeability after severe burn].
The changes in the intestinal mucosal permeability were observed by quantitatively assessing plasma to luminal clearance of 99mTc-labeled DTPA, and the influence of platelet activating factor (PAF) on it was investigated. The results showed that intestinal permeability was significantly elevated after severe burn and was positively correlated with increase in PAF in the intestinal tissue (r = 0.94, P < 0.01). PAF antagonist therapy could significantly attenuate postburn intestinal mucosal permeability. It is concluded that PAF is one of the important factors causing increased intestinal permeability after severe burn.
Yu
P
P
Burn Research Institute, Southwest Hospital, Third Military Medical College, Chongqing.
Xiao
G
G
Fu
W
W
D000818:Animals; D001381:Azepines / Q000494:pharmacology; D002056:Burns / Q000378:metabolism*; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D010539:Permeability; D010972:Platelet Activating Factor / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics; D014230:Triazoles / Q000494:pharmacology
D001381:Azepines; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D014230:Triazoles; C063964:bepafant; D016284:Technetium Tc 99m Pentetate