Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia.
Prevertebral sympathetic ganglia develop markedly enlarged argyrophilic neurites as a function of age, gender and diabetes. Immunolocalization studies demonstrate their preferential labeling with antisera to highly phosphorylated 200 kDa neurofilament (NF-H) epitopes, NPY, peripherin and synapsin I, but not to hypophosphorylated NF-M and NF-H or MAP-2. The immunophenotype of dystrophic neurites in conjunction with the results of histochemical and ultrastructural studies are consistent with the terminal axonal and/or synaptic origin of neuritic dystrophy in the sympathetic ganglia of aged and diabetic human subjects.
Schmidt
R E
RE
Department of Pathology, Division of Neuropathology, Washington University School of Medicine, Saint Louis, MO 63110, USA. reschmidt@pathology.wustl.edu
Beaudet
L N
LN
Plurad
S B
SB
Dorsey
D A
DA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001369:Axons / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure*; D003920:Diabetes Mellitus / Q000473:pathology*; D005455:Fluorescent Antibody Technique; D005725:Ganglia, Autonomic / Q000473:pathology*; D005728:Ganglia, Sympathetic / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016501:Neurites / Q000378:metabolism; D016900:Neurofilament Proteins / Q000378:metabolism; D010766:Phosphorylation
D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins