title: Failure of carbazochrome sodium sulfonate (AC-17) to prevent dengue vascular permeability or shock: a randomized, controlled trial.
abstract: OBJECTIVE
  We studied the ability of carbazochrome sodium sulfonate (AC-17) to prevent capillary permeability in dengue hemorrhagic fever/dengue shock syndrome.
  
  
  METHODS
  A randomized, placebo-controlled trial in 95 children stratified by age and sex was conducted in two hospitals during 1992. AC-17 (n = 45 cases) or B vitamins as placebo (n = 50) were given as a bolus infusion and then as a continuous drip for 24 hours; a total of 300 mg of AC-17 was administered on the first 2 days and 150 mg on the third day.
  
  
  RESULTS
  The two groups were comparable in age, sex, duration of illness, and clinical manifestations. No significant difference in shock or pleural effusion was noted between the two groups. Shock developed in 8.9% (4/45) of patients in the AC-17 group and 6% (3/50) in the placebo group (p = 0.44). Pleural effusion was found at 0, 24, 48, and 72 hours after admission in 4.4%, 20%, 31.1%, and 20% in the AC-17 group and 2%, 14%, 28%, and 14% in the placebo group, respectively.
  
  
  CONCLUSIONS
  Administration of AC-17 does not prevent plasma leakage or shock in dengue hemorrhagic fever/dengue shock syndrome.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Tassniyom
authors.forename: S
authors.initials: S
authors.lastname: Vasanawathana
authors.forename: T
authors.initials: T
authors.lastname: Dhiensiri
authors.forename: A
authors.initials: A
authors.lastname: Nisalak
authors.forename: A
authors.initials: A
authors.lastname: Chirawatkul
mesh_terms: D000323:Adrenochrome / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006490:Hemostatics / Q000494:pharmacology* / Q000627:therapeutic use*; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay; D008297:Male; D019595:Severe Dengue / Q000175:diagnosis / Q000188:drug therapy* / Q000534:rehabilitation; D017211:Treatment Failure
chemical_list: D006490:Hemostatics; D000323:Adrenochrome; C073338:carbazochrome