title: Periurethral collagen injection for male and female sphincteric incontinence: indications, techniques, and result.
abstract: Intrinsic sphincter deficiency is characterized by a poorly functioning intrinsic urethral sphincter, which leaks urine at relatively low pressures. Patients with this sort of incontinence are candidates for collagen implant therapy. Collagen is injected in the region of the bladder neck with success, depending on the precise placement of the collagen. There is generally a need to implant more collagen into men. The percentage of patients showing improvement in their incontinence after therapy is 58-100%. Over time the collagen is absorbed and there is a need to repeat the treatment. Collagen increases the abdominal leak-point pressure without reducing the flow rate or increasing the residual volume. Treatment failure does not prevent the performance of other procedures.
authors.affiliation: Division of Urology, University of Texas, Medical School at Houston 77030, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: McGuire
authors.forename: S F
authors.initials: SF
authors.lastname: English
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000628:therapy; D011468:Prostatectomy; D019736:Prostheses and Implants; D014521:Urethra; D001743:Urinary Bladder; D014550:Urinary Incontinence, Stress / Q000209:etiology / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; C048470:glutaraldehyde-cross-linked collagen; D003094:Collagen