The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer.
OBJECTIVE
To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF-RI) as a potential biochemical marker in women with cervical cancer.


METHODS
A prospective, case-controlled study.


METHODS
Seventy-one women with cervical cancer and 33 women with myoma were enrolled in this study.


METHODS
Pre-operative serum levels of sTNF-RI were measured with a standard enzyme-linked immunosorbent assay utilising murine monoclonal antibody against sTNF-RI.


METHODS
All data in both groups were evaluated and correlated with the pre-operative serum levels of sTNF-RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression.


RESULTS
The mean serum level of sTNF-RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF-RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF-RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF-RI and tumour size (r = -0.622, P < 0.0001).


CONCLUSIONS
Decreased pre-operative serum levels of sTNF-RI are observed in women with cervical cancer. The results do not support that the use of sTNF-RI as a biochemical marker for cervical cancer.
Sheu
B C
BC
Department of Obstetrics and Gynaecology, College of Medicine and the Hospital, National Taiwan University, Taipei, ROC.
Lin
H H
HH
Chang
D Y
DY
Ho
H N
HN
Huang
S C
SC
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000175:diagnosis*; D008875:Middle Aged; D011446:Prospective Studies; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000175:diagnosis; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D018124:Receptors, Tumor Necrosis Factor