title: [Efficacy of recombinant erythropoietin on the quality of life in patients over 60 years of age undergoing hemodialysis].
abstract: We followed for a period of six months, 54 patients of over 60 years old, submitted to hemodialitic treatment. We gave human recombinant erythropoietin, average dosage 50 UI/Kg subcutaneously on alternative days, folic acid and iron supplements together with a proteic supply of 1.2 g/Kg/die (35 Kcal/Kg). The medullary response has been monitored with hematochemical tests; blood pressure and nutritional conditions have been evaluated. Furthermore, the patients were given a questionnaire to evaluate their quality of life. At the end of the follow up, 50 patients responded positively to therapy. These patients showed an increase of RBC (from 2,789,780 +/- 259,310 to 3,313,110 +/- 472,780 p < 0.001) of HCT (from 21.86% +/- 2.16% to 27.18 +/- 2.74% p < 0.0001) and of Hb (from 7.72 +/- 1.12 g/dl to 9.28 +/- 0.98 g/dl p < 0.006). Total protein and albumin increased too. Furthermore they showed a progressive increase of "performance status". Our results confirm efficacy of erythropoietin in the treatment of anemia in elderly hemodialized patients.
authors.affiliation: Istituto Clinica Medica I, Ambulatorio di Dialisi e Plasmaferesi, Università di Roma La Sapienza.
authors.forename: G E
authors.initials: GE
authors.lastname: Russo
authors.forename: S
authors.initials: S
authors.lastname: Giusti
authors.forename: E
authors.initials: E
authors.lastname: Vitaliano
authors.forename: M S
authors.initials: MS
authors.lastname: Caramiello
authors.forename: M
authors.initials: M
authors.lastname: Maurici
authors.forename: C M
authors.initials: CM
authors.lastname: De Marco
authors.forename: M
authors.initials: M
authors.lastname: Pennacchia
authors.forename: F
authors.initials: F
authors.lastname: D'Auria
authors.forename: M
authors.initials: M
authors.lastname: Bonello
authors.forename: C
authors.initials: C
authors.lastname: Bruno
authors.forename: V
authors.initials: V
authors.lastname: Marigliano
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000523:psychology / Q000628:therapy*; D008297:Male; D011788:Quality of Life; D006435:Renal Dialysis / Q000009:adverse effects / Q000523:psychology
chemical_list: D004921:Erythropoietin