A closer view of an oncoprotein-tumor suppressor interaction.
The cellular response to DNA damage is coordinated by the p53 protein. Mdm2, an oncoprotein, inhibits p53 and promotes p53 degradation. A recent high-resolution structure of the Mdm2-p53 complex may aid the design of small molecules to disrupt this interaction, for use in investigating the interaction further and for designing anticancer drugs.
Shair
M D
MD
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. shair@chemistry.harvard.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D004249:DNA Damage; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D009363:Neoplasm Proteins / Q000737:chemistry / Q000494:pharmacology*; D009687:Nuclear Proteins; D011487:Protein Conformation; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000494:pharmacology*; D051736:Proto-Oncogene Proteins c-mdm2; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors* / Q000235:genetics
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2