title: [Structure-function relationship of the influenza virus RNA polymerase subunits].
abstract: Influenza virus RNA polymerase with the subunit structure PB1-PB2-PA is involved in both transcription and replication of the RNA genome. PB1 is the catalytic subunit and binds both to PB2 in its N-terminus and to PA in its C-terminus. PB2 is required for priming with cap and binds to PB1 in its N-terminus. PA is required for cRNA-->vRNA synthesis of genome replication and binds to PB1 in its C-terminus. Therefore, PB1 is the core subunit not only for RNA polymerase activity but also complex formation of the enzyme. Protease activity is identified in the N-terminal region of PA, but its role on viral proliferation remains unknown.
authors.affiliation: Department of Virology, Kurume University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Toyoda
mesh_terms: D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000502:physiology*; D009975:Orthomyxoviridae / Q000201:enzymology*; D013329:Structure-Activity Relationship
chemical_list: D012321:DNA-Directed RNA Polymerases