Charged with meaning: the structure and mechanism of phosphoprotein phosphatases.
Many phosphatases require two metal ions for catalysis. New structural information on two serine/threonine phosphatases offers insight into how the metals contribute to catalysis. A comparison with the structures of protein tyrosine phosphatases, which do not use metal ions, shows that the only similarity at the active site is that of charge.
Taylor
W P
WP
Department of Chemistry, Indiana University, Bloomington 47405, USA.
Widlanski
T S
TS
D001665:Binding Sites; D002384:Catalysis; D008670:Metals / Q000737:chemistry* / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation
D008670:Metals; D010749:Phosphoprotein Phosphatases