[Combined effects of high temperature and carbon monoxide on heat stress protein levels in rat brain and viscera].
Combined effects of high temperature and carbon monoxide (CO) on the amounts of heat stress protein 60 (HSP 60) and 70 (HSP 70) in rat brain and viscera were studied by western dot blot technique. Results showed that (1) amounts of HSP 60 in rat brain, spleen and kidney, as well as its rectal temperature, increased with CO concentrations, while those in heart decreased; and both of them showed synergistic effects on those in spleen and kidney, antagonistic ones in brain and liver, and synergistic ones of lowering them in heart; (2) amounts of HSP 70 changed with CO concentrations in five rat viscera, with synergism in brain, and antagonism in other organs; and (3) amounts of HSP 60 and 70 in most rat viscera and their body temperature were the most sensitive to 693.6 mg/m3 of CO.
Chen
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National Key Laboratory of Molecular Oncology Tumor Institute, Chinese Academy of Medical Sciences, Beijing.
Chen
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Pan
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D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000378:metabolism*; D002248:Carbon Monoxide / Q000009:adverse effects*; D018834:Chaperonin 60 / Q000378:metabolism*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006358:Hot Temperature; D007668:Kidney / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism; D013696:Temperature
D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins; D002248:Carbon Monoxide