Proximity versus allostery: the role of regulated protein dimerization in biology.
Regulated dimerization of proteins is increasingly understood to be important in many cellular processes, including signaling, transciption and protein degradation. Organic molecules that induce dimerization may offer as much potential to regulate biological processes as those that allosterically induce conformational change.
Austin
D J
DJ
Howard Hughes Medical Institute, Department of Chemistry, Harvard University, Cambridge, MA 02138, USA.
Crabtree
G R
GR
Schreiber
S L
SL
D000818:Animals; D019281:Dimerization; D006801:Humans; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
D011506:Proteins