title: Antinociceptive effect of some amaryllidaceae plants in mice.
abstract: The antinociceptive effects of ethanolic extracts of Pancratium maritimum L., Narcissus tazetta subspecies tazetta and Leucojum aestivum L. bulbs have been investigated in mice using the p-benzoquinone-induced abdominal constriction and hot-plate tests. In the p-benzoquinone-induced abdominal constriction test the ethanolic extracts of P. maritimum (300, 600 or 1200 mg kg-1, s.c.) and N. tazetta subsp. tazetta (5, 50, 100 or 200 mg kg-1, s.c.) caused dose-dependent inhibition of abdominal constrictions whereas a fluctuating response was obtained from ethanolic extracts of L aestivum (2.5-500 mg kg-1, s.c.). In the hot-plate test P. maritimum and L. aestivum caused a significant increase of latency only at the highest concentrations used (1200 mg kg-1 and 500 mg kg-1, i.p., respectively). However, at these concentrations they also caused significant toxic effects. In contrast with P. maritimum and L. aestivum, N. tazetta subsp. tazetta (5-500 mg kg-1, i.p.) extracts had no antinociceptive effect in this test. These findings indicate that the antinociceptive effect of Amaryllidaceae plants differs depending on the model of nociception investigated.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Cakici
authors.forename: H Y
authors.initials: HY
authors.lastname: Ulug
authors.forename: S
authors.initials: S
authors.lastname: Inci
authors.forename: B
authors.initials: B
authors.lastname: Tunçtan
authors.forename: N
authors.initials: N
authors.lastname: Abacioglu
authors.forename: I
authors.initials: I
authors.lastname: Kanzik
authors.forename: B
authors.initials: B
authors.lastname: Sener
mesh_terms: D000005:Abdomen; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000431:Ethanol / Q000737:chemistry; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D000431:Ethanol