Immunohistochemical analysis of growth factor expression and localization in gastric coronary vein of cirrhotic patients.
This study was designed to investigate the expression and localization of PDGF, bFGF, EGF, and TGF alpha in gastric coronary vein of cirrhotic (n = 30) and non-cirrhotic patients (n = 10) using immunohistochemical technique. The strongly positive immunostaining rate were 93%, 89%, 70% and 68% respectively in cirrhotic patients. The immunostaining was negative in non-cirrhotic patients. The damage to endothelium, hypertrophy and hyperplasia of vascular smooth muscle cells and vascular remodeling were seen in gastric coronary vein of cirrhotic patients. These results suggested that gastric coronary vein could produce growth factor during cirrhosis, the growth factor can act on the vascular function and/or structure via autocrine-paracrine mechanism.
Yang
Z
Z
Department of Surgery, Tongji Hospital, Tongji Medical University, Wuhan.
Tian
L
L
Peng
L
L
Qiu
F
F
D000328:Adult; D004730:Endothelium, Vascular / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000096:biosynthesis; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis; D006801:Humans; D006975:Hypertension, Portal / Q000378:metabolism*; D007150:Immunohistochemistry; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis*; D013270:Stomach / Q000098:blood supply*; D016211:Transforming Growth Factor alpha / Q000096:biosynthesis
D010982:Platelet-Derived Growth Factor; D016211:Transforming Growth Factor alpha; D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor