title: Progress in antisense therapeutics discovery and development.
abstract: Progress in the discovery and development of antisense therapeutics continues at a rapid pace. Detailed understanding of the pharmacokinetic, toxicological and pharmacological properties of phosphorothioate oligonucleotides is now available. Further, an ever-increasing body of information is available about new and improved chemical classes of antisense drugs that are progressing toward clinical trials.
authors.affiliation: Isis Pharmaceuticals Inc., Carlsbad Research Center, CA 92008, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Crooke
mesh_terms: D000818:Animals; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000627:therapeutic use*; D013873:Thionucleotides / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D016376:Oligonucleotides, Antisense; D013873:Thionucleotides