Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome.
The study was conducted to assess leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome (PCOS). Twenty-two women with PCOS and 19 control healthy women were included in the study, divided into obese and non-obese groups. Leptin was determined using Linco Research radio-immunoassay while insulin sensitivity was calculated from intravenous glucose tolerance tests with frequent blood sampling using MINMOD analysis. Significantly higher basal leptin levels were found in obese compared to non-obese PCOS (31.76 +/- 3.06 vs. 10.42 +/- 2.31 ng/ml; p < 0.05) as well as in obese in comparison to non-obese controls (29.16 +/- 5.06 vs 8.51 +/- 0.88 ng/ml; p < 0.05). A negative correlation was found between insulin sensitivity and leptin levels in both obese (r = -0.2480; p > 0.05) and non-obese PCOS groups (r = -0.4620; p > 0.05). In conclusion, high serum leptin, insulin and testosterone levels together with reduced insulin sensitivity were found in obese PCOS women, suggesting that high leptin levels could be a characteristic of the obese PCOS phenotype.
Micić
D
D
Institute of Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Beograd, Yugoslavia.
Macut
D
D
Popović
V
V
Sumarac-Dumanović
M
M
Kendereski
A
A
Colić
M
M
Dieguez
C
C
Casanueva
F F
FF
D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin; D009765:Obesity / Q000097:blood / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications*; D011506:Proteins / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
D007328:Insulin; D020738:Leptin; D011506:Proteins; D013739:Testosterone