Effect of growth hormone suppression on the serum levels of ovarian and adrenal sex steroid hormones in normal women and in women with polycystic ovary syndrome.
We investigated the acute effect on the serum levels of ovarian and adrenal sex steroid hormones of the suppression of growth hormone during oral glucose tolerance test (OGTT). A standard 75 g OGTT was performed in 11 healthy women and eight women with polycystic ovary syndrome (PCOS). Another five controls were given a sham loading of oral distilled water. Blood samples were obtained immediately before and at 30-minute intervals after glucose or sham loading. Significant progressive declines in testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS) and growth hormone levels were observed during OGTT in both groups. In the PCOS and normal groups, respectively, at 120 min, testosterone levels were 75.8% and 64.4% of the baseline (0-time) value, estradiol levels were 83.4% and 83.1%, DHEAS levels were 79.3% and 79.1%, and growth hormone levels were 33.9% and 21.2%. Significant positive correlations were observed between the level of growth hormone and each of the testosterone, estradiol and DHEAS levels in both the groups. The area under the curve for growth hormone was significantly smaller in the PCOS group than in the normal group. Gonadotropins were not changed at any time during OGTT. It appears that growth hormone may modify ovarian and adrenal sex steroidogenic responses to tropic hormones directly or via local insulin-like growth factor-I. Women with PCOS may be relatively deficient in growth hormone, a deficiency which may play a role in the pathophysiology of ovulatory disturbance.
Takeuchi
T
T
Department of Obstetrics and Gynecology, Branch Hospital, Faculty of Medicine, University of Tokyo, Japan.
Kawana
T
T
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D012739:Gonadal Steroid Hormones / Q000097:blood*; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013739:Testosterone / Q000097:blood
D001786:Blood Glucose; D012739:Gonadal Steroid Hormones; D007328:Insulin; D019382:Human Growth Hormone; D013739:Testosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone