title: Dynamic characterization of a new accelerated heart valve tester.
abstract: This paper presents a new accelerated prosthetic heart valve tester prototype that incorporates a camshaft and poppet valves. A three element Windkessel system is used to mimic the afterload of the human systemic circulation. The device is capable of testing eight valves simultaneously at a rate up to 1,250 cycles/min, while the flow rate, the pressure, and the valve loading can be monitored and adjusted individually. The tester was characterized and calibrated using a set of eight Carpentier-Edwards bioprostheses at a flow rate varying between 3 and 5 L/min. The experiment was carried out with the pressure difference across the closed heart valve maintained between 140 and 190 mmHg. Smooth and complete opening and closing of the valve leaflets was achieved at all cycling rates. This confirms that the velocity profiles approaching the test valves were uniform, an important factor that allows the test valves to open and close synchronously each time.
authors.affiliation: Department of Biomedical Engineering, University of Miami, Coral Gables, Florida 33124, USA.
authors.forename: F
authors.initials: F
authors.lastname: Menzler
authors.forename: A D
authors.initials: AD
authors.lastname: Haubold
authors.forename: N H
authors.initials: NH
authors.lastname: Hwang
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering / Q000295:instrumentation; D001705:Bioprosthesis / Q000009:adverse effects; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D011312:Pressure