Association of cholinesterases with amyloid in extracellular neurofibrillary tangles.
Double-labeling techniques conclusively demonstrated that extracellular neurofibrillary tangles immunoreactive for beta protein were also positive for cholinesterases. Ultrastructurally, cholinesterases decorated bundles of amyloid-like filaments, which appeared intermingled with straight filaments and cellular processes. A lighter labeling of esterases was also seen over most straight filaments. These observations extend the consistent association of cholinesterases with fibrillary beta-amyloid protein to a new location in neurofibrillary tangles.
Cebrián
J L
JL
Department of Morphology, School of Medicine, Autónoma University, Madrid, Spain.
Morán
M A
MA
Gómez-Ramos
P
P
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002802:Cholinesterases / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D008854:Microscopy, Electron; D016874:Neurofibrillary Tangles / Q000378:metabolism* / Q000473:pathology; D012016:Reference Values
D016229:Amyloid beta-Peptides; D002802:Cholinesterases