[The effect of nifedipine on the microcirculation in pregnancy-induced hypertension].
OBJECTIVE
To study the effects of nifedipine on the microcirculation in pregnancy-induced hypertension (PIH).


METHODS
We observed the microcirculation in nailfold of 30 normal pregnant women and 76 cases of PIH. 20 mg nifedipine was given and nailfold microcirculation was observed after 30 minutes.


RESULTS
Nifedipine increased the velocity of blood flow, reduced the aggregation of erythrocytes, and dilated capillaries. After the administration of nifedipine, the total score of the nailfold microcirculation decreased significantly in mild and moderate PIH (P < 0.05), but no marked difference was observed in severe PIH cases (P > 0.05).


CONCLUSIONS
The disorder of the microcirculation of PIH can be improved by nifedipine.
Hao
C
C
Affiliated Hospital of Binzhou Medical College, Shandong Binzhou.
Yu
X
X
Li
F
F
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008833:Microcirculation / Q000187:drug effects; D009262:Nails / Q000098:blood supply; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy
D002121:Calcium Channel Blockers; D009543:Nifedipine