title: CD30+ lymphocytes in chronic gingivitis from HIV-positive patients: a pilot study.
abstract: Th2 type lymphocytes are characterized by high expression of CD30 glycoprotein. Increased serum levels of CD30 and Th2 IL-4 producing T-cells are found during AIDS progression. Since HIV-positive patients are more susceptible to periodontal disease, quantitative analysis of positive cells for the CD30 receptor in chronic gingivitis of both HIV-infected and non-infected patients (NSG) would help to clarify the immunoregulation of HIV-associated periodontal diseases. The purpose of this study was to evaluate CD30+ lymphocytes in gingival biopsies from sites exhibiting chronic gingivitis on HIV-positive patients (CG-HIV) and NSG. A biotin-streptavidin amplified system was used for identification of the CD30 receptor. The results demonstrated increased proportions of Th2 cells in CG-HIV as compared to NSG. Additional studies are necessary to understand the importance of these cells to the biological activity or inactivity of the disease.
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Minas Gerais Federal University, Belo Horizonte, Brazil.
authors.forename: R S
authors.initials: RS
authors.lastname: Gomez
authors.forename: P E
authors.initials: PE
authors.lastname: de Souza
authors.forename: J E
authors.initials: JE
authors.lastname: da Costa
authors.forename: N S
authors.initials: NS
authors.lastname: Araújo
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000328:Adult; D001706:Biopsy; D001710:Biotin; D053285:CD30 Ligand; D016022:Case-Control Studies; D002908:Chronic Disease; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D005891:Gingivitis / Q000276:immunology*; D018023:HIV Seronegativity / Q000276:immunology; D006679:HIV Seropositivity / Q000276:immunology*; D006801:Humans; D007202:Indicators and Reagents; D015847:Interleukin-4 / Q000097:blood; D017730:Ki-1 Antigen / Q000032:analysis* / Q000097:blood; D008024:Ligands; D018655:Lymphocyte Count; D008562:Membrane Glycoproteins / Q000032:analysis; D008875:Middle Aged; D010865:Pilot Projects; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D019809:Streptavidin; D013601:T-Lymphocytes / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology*
chemical_list: D053285:CD30 Ligand; D007202:Indicators and Reagents; D017730:Ki-1 Antigen; D008024:Ligands; D008562:Membrane Glycoproteins; D011948:Receptors, Antigen, T-Cell; C505774:TNFSF8 protein, human; D015847:Interleukin-4; D001710:Biotin; D019809:Streptavidin