title: A randomized, prospective study comparing once-daily gentamicin versus thrice-daily gentamicin in the treatment of puerperal infection.
abstract: OBJECTIVE
  The efficacy, safety, and antibiotic-related charges for once-daily gentamicin with twice-daily clindamycin were compared with those of thrice-daily dosing of these antibiotics.
  
  
  METHODS
  Patients with puerperal endometritis or with chorioamnionitis in labor assessed to be at risk for endometritis were randomized to receive gentamicin 4 mg/kg intravenously every 24 hours with clindamycin 1200 mg intravenously every 12 hours (experimental arm) or gentamicin 1.33 mg/kg intravenously and clindamycin 800 mg intravenously every 8 hours (conventional dosing interval arm). Primary outcomes included cure rates, mean length of treatment, antibiotic-related charges, and nephrotoxicity. Multiple logistic regression analysis was used to control for confounding variables.
  
  
  RESULTS
  There were 135 and 137 patients randomized to the experimental and conventional interval arms, respectively. Cures were obtained in 94.1% and 87.6% of patients in the experimental and conventional arms, respectively (p = 0.06). The experimental arm had mean antibiotic charges of $250.79 versus $442.49 in the conventional arm (p < 0.0001). There was no permanent nephrotoxicity in either group.
  
  
  CONCLUSIONS
  Once-daily gentamicin dosing with twice-daily clindamycin dosing is as efficacious and safe as the thrice-daily dosing of gentamicin and clindamycin for peripartum uterine infection. The experimental regimen results in substantial cost savings. The incidence of nephrotoxicity is low.
authors.affiliation: Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte, North Carolina, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Mitra
authors.forename: M K
authors.initials: MK
authors.lastname: Whitten
authors.forename: S L
authors.initials: SL
authors.lastname: Laurent
authors.forename: W E
authors.initials: WE
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002821:Chorioamnionitis / Q000188:drug therapy; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use; D036861:Delivery, Obstetric; D004716:Endometritis / Q000188:drug therapy; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D007743:Labor, Obstetric; D016015:Logistic Models; D011247:Pregnancy; D011446:Prospective Studies; D011645:Puerperal Infection / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002981:Clindamycin