[Transplantation of human primary in-situ and invasive breast carcinoma in nude mice].
In order to establish nude mice model of early and advanced breast cancers, 15 in-situ breast carcinomas and 31 invasive breast carcinomoas were transplanted in 155 nude mice subcutaneously. A slow-release pellet of 17-beta estradiol was also implanted subcutaneously. During ten months of observation, the in-situ breast cancer tissue eventually did not grow. Light microscopy showed that the implants kept the structure of in-situ carcinoma without invasion. Of 31 invasive carcinomas, only one diagnosed pathologically as multifocal dedifferentiated ductal carcinoma grew well and was serially passaged. It was estrogen- and progesterone-receptor negative, p53 protein negative and c-erbB-2 protein positive. Its DNA ploidy was near tetraploidy.
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Hubei Cancer Institute, Wuhan.
Andersen
J A
JA
D000328:Adult; D000818:Animals; D001943:Breast Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D002278:Carcinoma in Situ / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011123:Polyploidy; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis
D004273:DNA, Neoplasm; D018719:Erb-b2 Receptor Tyrosine Kinases