[Experimental study of Salvia miltiorrhiza on prevention of restenosis after angioplasty].
For evaluating the possibility of Salvia miltiorrhiza (SM) on the prevention of arterial restenosis after angioplasty, we investigated the effect of SM on the intimal thickening of air-injured carotid artery of rats. The results showed that the maximal intimal thickness of the injured arteries was much thinner in the treatment group than that in the control group, indicated that SM could prevent experimental restenosis in rat model. Furthermore, we examined the effect of SM on the proliferation of the isolated rabbit arterial smooth muscle cells (SMC) cultivated in vitro. The results showed that SM inhibited the 3H-TdR take-up and proliferation of SMC in a dose-dependent manner. The study raised the possibility that SM could be used to prevent arterial restenosis after angioplasty.
Zhou
X M
XM
Cardiology Department, Tongji Hospital, Tongji Medical University, Wuhan.
Lu
Z Y
ZY
Wang
D W
DW
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D016893:Carotid Stenosis / Q000473:pathology / Q000517:prevention & control* / Q000628:therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010936:Plant Extracts; D011817:Rabbits; D051381:Rats; D012008:Recurrence; D027561:Salvia miltiorrhiza; D017539:Tunica Intima / Q000473:pathology; D014665:Vasodilator Agents / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D014665:Vasodilator Agents