Vestibulo-ocular reflex deficits to rapid head turns following intratympanic gentamicin instillation.
The response of the vestibulo-ocular reflex following unilateral vestibular deafferentation by gentamicin ablation was studied using transient stimuli. The response to these rapid passive head turns showed a strong asymmetry with permanent, reduced gains toward the side of lesion. These gain reductions have large variation (gains of 0.26 to 0.83), which may result from preferential sparing of regularly firing afferent fibers following gentamicin ablation. Based on the size and nature of the nonlinearity, an explanation based on Ewald's second law was discounted.
Allison
R S
RS
Department of Electrical and Computer Engineering, University of Toronto, Canada.
Eizenman
M
M
Tomlinson
R D
RD
Nedzelski
J
J
Sharpe
J A
JA
D000328:Adult; D000344:Afferent Pathways / Q000502:physiology; D000368:Aged; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D019416:Head Movements; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008575:Meniere Disease / Q000628:therapy*; D008875:Middle Aged; D008959:Models, Neurological; D009412:Nerve Fibers / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D013563:Sympathectomy, Chemical / Q000009:adverse effects*; D014722:Vestibule, Labyrinth
D005839:Gentamicins