Minor histocompatibility antigens.
The existence of transplantation antigens, in addition to those encoded by genes in the MHC, has been known for over half a century. The molecular identification of these additional minor histocompatibility (H) antigens lagged behind that of their MHC counterparts, largely because minor H antigens are recognised by T cells and not by antibodies. In the past year, however, new minor H antigens have been identified at both the genetic and protein level and include Uty, a second novel gene encoding a male-specific epitope in mice, a novel autosomal gene encoding each of the H-13 alleles of mice, and a second male-specific epitope encoded by the SMCY gene.
Simpson
E
E
Transplantation Biology Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK. vtikerpa@rpms.ac.uk
Roopenian
D
D
D000818:Animals; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology; D051379:Mice; D015778:Minor Histocompatibility Antigens; D013601:T-Lymphocytes / Q000276:immunology
D015778:Minor Histocompatibility Antigens