title: Intraoperative monitoring of substrate delivery during aneurysm and hematoma surgery: initial experience in 16 patients.
abstract: The effects of proximal occlusion of the parent artery during aneurysm surgery in humans are not fully understood, although this method is widely used. The reduction in substrate that can be tolerated by normal and subarachnoid hemorrhage (SAH)-affected brain is unknown. Therefore, the authors measured brain oxygen tension (brain PO2), carbon dioxide tension (brain PCO2), pH, and hemoglobin oxygen (HbO2) saturation before and after temporary occlusion in 12 patients with aneurysms. The effect of removal of a traumatic intracranial hematoma on cerebral oxygenation was also studied in four severely head injured patients. A multiparameter sensor was placed in the cortex of interest and locked by means of a specially designed skull bolt. The mean arterial blood pressure, inspired O2 fraction, and end-tidal PCO2 were analyzed. Brain PO2 and HbO2 saturation data were collected every 10 seconds. Descriptive and nonparametric analyses were used to analyze the data. A wide range in baseline PO2 was seen, although a decrease from baseline in brain PO2 was found in all patients. During temporary occlusion, brain PO2 in patients with unruptured aneurysm (seven patients) dropped significantly, from 60 +/- 31 to 27 +/- 17 mm Hg (p < 0.05). In the SAH group (five patients), the brain PO2 dropped from 106 +/- 74 to 87 +/- 73 mm Hg (not significant). Removal of intracranial hematomas in four severely head injured patients resulted in a significant increase in brain PO2, from 13 +/- 9 to 34 +/- 13 mm Hg (p < 0.05). The duration of safe temporary occlusion could not be determined from this group of patients, because none developed postoperative deterioration in their neurological status. However, the data indicate that this technique is useful to detect changes in substrate delivery during intraoperative maneuvers. This study also reemphasizes the need for emergency removal of intracranial hematomas to improve substrate delivery in severely head injured patients.
authors.affiliation: Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0631, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Doppenberg
authors.forename: J C
authors.initials: JC
authors.lastname: Watson
authors.forename: W C
authors.initials: WC
authors.lastname: Broaddus
authors.forename: K L
authors.initials: KL
authors.lastname: Holloway
authors.forename: H F
authors.initials: HF
authors.lastname: Young
authors.forename: R
authors.initials: R
authors.lastname: Bullock
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000601:surgery; D001794:Blood Pressure; D001863:Bone Screws; D002245:Carbon Dioxide / Q000097:blood / Q000378:metabolism; D002536:Cerebral Arteries / Q000601:surgery*; D002540:Cerebral Cortex / Q000378:metabolism*; D003250:Constriction; D006259:Craniocerebral Trauma / Q000150:complications; D003399:Craniotomy / Q000295:instrumentation / Q000379:methods; D005260:Female; D006408:Hematoma, Subdural / Q000209:etiology / Q000601:surgery*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009460:Neurologic Examination; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood; D010101:Oxygen Consumption; D013345:Subarachnoid Hemorrhage / Q000601:surgery*; D013990:Tidal Volume; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D002245:Carbon Dioxide; D010100:Oxygen