title: [Transarterial immuno-embolization therapy in patients with hepatocellular carcinoma].
abstract: Surgical resection, transcatheter arterial embolization (TAE) and percutaneous ethanol injection therapy (PEIT) are effective for hepatocellular carcinoma (HCC), but the recurrence rate is high. We have devised a new therapy of transarterial immuno-embolization (TIE) with OK-432, fibrinogen and thrombin, and 2 cases are reported. Case 1: A 78-year-old Japanese male with HCC (diameter, 4 cm in subsegment 5) received TIE. The tumor size was markedly decreased, and the patient survived for more than 3 years without recurrence. Case 2: A 61-year-old Japanese male with HCC (diameter, 4.5 cm in segment 5) received hepatic subsegmentectomy following TIE. Histological examination of resected specimens following TIE showed massive infiltration of mononuclear cells in the main tumor. Tumor recurrence had developed three times thereafter, but was effectively treated by TIE. TIE may be an effective therapy for HCC.
authors.affiliation: Dept. of Surgery 2, Osaka University Medical School.
authors.forename: H
authors.initials: H
authors.lastname: Eguchi
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Sakon
authors.forename: K
authors.initials: K
authors.lastname: Umeshita
authors.forename: H
authors.initials: H
authors.lastname: Ohzato
authors.forename: K
authors.initials: K
authors.lastname: Dono
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: T
authors.initials: T
authors.lastname: Monden
authors.forename: M
authors.initials: M
authors.lastname: Monden
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D004621:Embolization, Therapeutic; D005340:Fibrinogen / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007167:Immunotherapy; D007459:Iodized Oil / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage*; D013917:Thrombin / Q000008:administration & dosage
chemical_list: D010844:Picibanil; D007459:Iodized Oil; D005340:Fibrinogen; D013917:Thrombin