title: Five-year follow-up of asymptomatic patients with negative fecal occult blood test results in whom clinically significant colorectal pathology was detected.
abstract: OBJECTIVE
  To determine from a 5-yr longitudinal study (a) rate of compliance with follow-up, (b) number of new clinically significant colorectal lesions discovered by sigmoidoscopy or colonoscopy at later examination, (c) number and causes of deaths, and (d) rate of diagnosis of new cancers among 36 asymptomatic patients with negative fecal occult blood tests in whom clinically significant colorectal lesions were found initially by 60-cm flexible sigmoidoscope.
  
  
  METHODS
  For the 36 patients, medical records were reviewed throughout the 5-yr study period. These records included pathology reports, results from 60-cm sigmoidoscopy and colonoscopy examinations, and notations from visits to health facilities for reasons other than colorectal examinations.
  
  
  RESULTS
  Seventy-one clinically significant lesions were removed during the 5-yr period; 58 were discovered by sigmoidoscopy and 13 by colonoscopy. Also, during the 5-yr period, noncolorectal cancer was diagnosed in six patients, and two patients died of cardiac disease.
  
  
  CONCLUSIONS
  Patients who have clinically significant colorectal pathology found by 60-cm sigmoidoscope have a high prevalence of lesions beyond the view of this instrument. Therefore, colonoscopy should be performed when sigmoidoscopy shows clinically significant pathology. Because subsequent examinations show a high incidence of new lesions, rescreening is indicated.
authors.affiliation: Department of Family Medicine, University of Southern California School of Medicine, Los Angeles, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Cauffman
authors.forename: R A
authors.initials: RA
authors.lastname: Forsyth
authors.forename: F X
authors.initials: FX
authors.lastname: Lapsys
authors.forename: V
authors.initials: V
authors.lastname: Clark
mesh_terms: D000368:Aged; D003113:Colonoscopy / Q000706:statistics & numerical data; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D005188:False Negative Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009780:Occult Blood; D010349:Patient Compliance; D013997:Time Factors