P53 gene product and EGF-receptor are highly expressed in placental site trophoblastic tumor.
Immunohistochemical analysis of curettage material from a placental site trophoblastic tumor (PSTT) revealed a high expression of p53 gene products, of epidermal growth factor receptor (EGF-R) and of Ki-67 (MIB-1) proliferation associated antigen. bcl-2 was not expressed. These results show that in PSTT inactivation/dysregulation of p53 and upregulation of EGF-R and MiB-1 occurs, indicating that these factors are probably involved in tumor genesis and propagation of PSTT. The prognostic significance of the molecular genetic data, however, remains to be established.
Müller-Höcker
J
J
Pathologisches Institut, Ludwig-Maximilians-Universität, München, Germany.
Obernitz
N
N
Johannes
A
A
Löhrs
U
U
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000032:analysis; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D010928:Placental Lactogen / Q000032:analysis; D011247:Pregnancy; D018245:Trophoblastic Tumor, Placental Site / Q000737:chemistry*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D014594:Uterine Neoplasms / Q000737:chemistry*
D015415:Biomarkers; D006063:Chorionic Gonadotropin; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53; D010928:Placental Lactogen; D066246:ErbB Receptors