[An experimental study of regional spontaneous portasystemic shunt in cirrhotic rats].
CCl4 induced splenic portasystemic shunt (SPSS) was measured in 11 CCl4-induced cirrhotic rats and 10 controls, and mesenteric shunt (MPSS) was measured in 11 controls. 125I labeled albumin microspheres was used as nuclear markers for measurement of shunting rate. It was found that, portal resistance, free portal pressure, wedged hepatic venous pressure, portahepatic venous pressure gradient were all elevated markedly in cirrhotic rats, while the volume of portal flow had no significant difference between the two groups. SPSS and MPSS were higher remarkably those that in the normal controls, and SPSS was greater than MPSS significantly. It suggested that splenogastric venous bed is the main area for compensatory shunt and also the dangerous site of bleeding. Portaazygous disconnection is the operation of choice for control of bleeding. However it could impair the mechanism of spontaneous shunting compensation seriously. Disconnection operation combined with splenorenal shunt seems to be a reseasonable consideration.
Huang
Y
Y
Department of Surgery, First Hospital, Beijing Medical University.
Fan
L
L
D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D006439:Hemodynamics; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D008642:Mesenteric Veins / Q000503:physiopathology; D011169:Portal Vein / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013162:Splenic Vein / Q000503:physiopathology