Enhancement of the affinity of androgen receptor in the adrenal medulla of spontaneously hypertensive rats.
We investigated the alteration of tyrosine hydroxylase (TH) mRNA expression and androgen receptor in the adrenal medulla of spontaneously hypertensive rats (SHR). The TH mRNA expression in the adrenal medulla of SHR was higher than that of Wistar Kyoto rats (WKY). The testosterone increased the TH mRNA expression of SHR, but not WKY. The affinity of androgen receptor in the adrenal medulla of SHR was higher than that of WKY; however, the number of androgen receptor was not different. These results suggested that the increased binding affinity of the androgen receptor of SHR may be related to TH gene transcription in the adrenal medulla.
Kumai
T
T
Department of Pharmacology, St. Marianna University School of Medicine, Kanagawa, Japan.
Tanaka
M
M
Tateishi
T
T
Watanabe
M
M
Nakura
H
H
Kobayashi
S
S
D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D011467:Prostate / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011944:Receptors, Androgen / Q000378:metabolism*; D013223:Statistics as Topic; D013739:Testosterone / Q000097:blood / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D012333:RNA, Messenger; D011944:Receptors, Androgen; D013739:Testosterone; D014446:Tyrosine 3-Monooxygenase