title: [Studies on the metabolites of tetramethylpyrazine in human urine].
abstract: Tetramethylpyrazine (TMP), an active ingredient in Chuanxiong (Ligusticum Wallich Franch), a traditional Chinese herb, has been widely used especially in the treatment of patients with cerebral ischemic diseases in China. TMP was reported to have a short half-life time because of its rapid metabolism in the liver. In this paper we studied its metabolites in human urine with GC/MS after oral administration of TMP. Three metabolites were found in the water soluble acidic fraction of the urine and the main metabolite was identified to be 3,.5,6-trimethylpyrazinecarboxylic acid.
authors.affiliation: PUMC Hospital, CAMS, Beijing.
authors.forename: Y
authors.initials: Y
authors.lastname: Ye
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D011719:Pyrazines / Q000378:metabolism* / Q000652:urine*; D014665:Vasodilator Agents / Q000652:urine*
chemical_list: C109800:3,5,6-trimethylpyrazinecarboxylic acid; D011719:Pyrazines; D014665:Vasodilator Agents; C017953:tetramethylpyrazine