title: Capillary electrophoresis enantioseparation of noncharged and anionic chiral compounds using anionic cyclodextrin derivatives as chiral selectors.
abstract: The electrophoretic profiles of anionic cyclodextrin derivatives were studied in benzoic acid and phosphate buffers. All anionic derivatives studied exhibited a multicomponent profile. The mobilities of beta-cyclodextrin (beta-CD) sulfates do not depend substantially on the pH. Carboxymethyl ether of beta-cyclodextrin (CM-beta-CD) possesses marked self-mobility at pH 4.5, and as a result, it separates a number of neutral analytes at this pH. Sulfated beta-CD derivatives also exhibit chiral recognition abilities toward neutral compounds, and additionally, the anionic sulfobutyl ether of beta-cyclodextrin (SBE-beta-CD) successfully resolves the chiral solutes warfarin and acenocoumarol also in the anionic form.
authors.affiliation: Department of Chemistry, Tbilisi State University, Republic of Georgia.
authors.forename: B
authors.initials: B
authors.lastname: Chankvetadze
authors.forename: G
authors.initials: G
authors.lastname: Endresz
authors.forename: G
authors.initials: G
authors.lastname: Blaschke
mesh_terms: D000838:Anions; D003505:Cyclodextrins / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D019075:Electrophoresis, Capillary / Q000379:methods*; D055672:Static Electricity
chemical_list: D000838:Anions; D003505:Cyclodextrins