[The effect of Essentiale and riboxin on the immunomodulating properties of the erythrocytes in a toxic liver lesion].
D-galactosamine (DGA) increases the erythrocyte content of malonic dialdehyde (MDA) and the degree of peroxide hemolysis (DPH) of the erythrocytes, and reduces the 2,3-diphosphoglycerate (DPG) and ATP content. DGA induces the appearance of immunosuppressive properties in light erythrocytes. Essentiale (2 mg/kg) reduces the MDA content and DPH in the heavy erythrocytes and induces the appearance of immunostimulating properties in them. Riboxine (2 mg/kg) reduces the content of DPG and ATP in the light erythrocytes and prevents the appearance of immunosuppressive properties in them. Injection of 2 mg/kg of Essentiale or riboxine does not affect the development of the immune response induced by sheep erythrocytes in DGA poisoned rats. Combined injection of the compounds in a dose of 1 mg/kg intensifies the immune response of the poisoned animals.
Uteshev
B S
BS
Konoplia
E N
EN
Laskova
I L
IL
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D005688:Galactosamine / Q000506:poisoning; D007114:Immunization; D007290:Inosine Diphosphate / Q000494:pharmacology / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D010713:Phosphatidylcholines / Q000494:pharmacology / Q000627:therapeutic use*; D011041:Poisoning / Q000097:blood / Q000188:drug therapy / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar
D000276:Adjuvants, Immunologic; D010713:Phosphatidylcholines; C011246:essential 303 forte; D005688:Galactosamine; D007290:Inosine Diphosphate