Molecular approaches to cancer immunotherapy.
The use of cytokines and costimulatory molecule gene-engineered tumor cells to enhance tumor immunogenicity and elicit curative responses against established tumors and tumor recurrences has become an attractive prospect. The immunotherapy data obtained in many experimental tumor systems using these engineered cells are reviewed here to provide a realistic assessment of the potential and limits of this technique.
Forni
G
G
Centro CNR di Immunogenetica ed Oncologia Sperimentale, Universita di Torino, Italy.
Cavallo
F
F
Consalvo
M
M
Allione
A
A
Dellabona
P
P
Casorati
G
G
Giovarelli
M
M
D000818:Animals; D003115:Colony-Stimulating Factors / Q000096:biosynthesis* / Q000235:genetics / Q000627:therapeutic use*; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics / Q000627:therapeutic use*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007372:Interferons / Q000096:biosynthesis / Q000627:therapeutic use; D007378:Interleukins / Q000096:biosynthesis / Q000627:therapeutic use; D009369:Neoplasms / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy*
D003115:Colony-Stimulating Factors; D016207:Cytokines; D007378:Interleukins; D007372:Interferons