title: The respiratory burst oxidase.
abstract: The respiratory burst oxidase catalyzes the production of O2- by activated phagocytes and B lymphocytes. Activation is accomplished by any number of signal transduction pathways, and involves protein kinase C, MAP kinase, or both, and perhaps lipid-mediated pathways. Failure of O2- production is characteristic of chronic granulomatous disease, an inherited disorder of phagocyte function. A number of new mutations responsible for chronic granulomatous disease have been reported. O2- production is also altered in other diseases, most notably certain hematologic malignancies.
authors.affiliation: Scripps Research Institute, La Jolla, California, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Babior
mesh_terms: D004789:Enzyme Activation; D006105:Granulomatous Disease, Chronic / Q000201:enzymology*; D006801:Humans; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D019255:NADPH Oxidases; D010100:Oxygen / Q000097:blood
chemical_list: D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; C022709:superoxide-forming enzyme; D010100:Oxygen