Imaging of Hand-Schüller-Christian syndrome by a monoclonal antibody.
OBJECTIVE
Multifocal eosinophilic granuloma (Hand-Schüller-Christian syndrome) consists of localized lesions of histiocytosis X originating from proliferating Langerhans' cells involving male children and young adults.


METHODS
The authors present the first case of multifocal eosinophilic granuloma that was imaged by Tc-99m monoclonal antibody BW250/183 recognizing NCA-95 antigen on granulocytes. A 30-year-old man had a diagnosis of histiocytosis X for 16 years.


RESULTS
All active known lesions were visualized. The previous radiotherapy fields were also accurately demonstrated as areas with no antibody accumulation. Bone marrow biopsy taken 30 hours after injection showed no infiltrations, but mild hypoplasia suggesting chronic disease was demonstrated. Retrospectively, the authors performed digital autoradiography from tissue samples and found specific targeting with the same BW250/183 antibody.


CONCLUSIONS
Their results indicate that antibody targeting is possible in multifocal eosinophilic granuloma, probably even allowing radioimmunotherapy.
Jekunen
A P
AP
Department of Oncology, Helsinki University Central Hospital, Finland.
Kairemo
K J
KJ
Paavonen
T
T
D000328:Adult; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D001842:Bone and Bones / Q000000981:diagnostic imaging; D015815:Cell Adhesion Molecules; D006098:Granulocytes / Q000276:immunology; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology; D011877:Radionuclide Imaging; D013667:Technetium
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D013667:Technetium