All roads lead to Rome? The multiple pathways of protein folding.
Recent studies have found that protein folding reactions often proceed through two or more kinetically distinct pathways. In at least some cases, the observed folding intermediates act as kinetic traps, slowing the rate at which folding is completed. These findings have important implications for understanding how proteins fold in vitro and in vivo.
Weissman
J S
JS
Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
D000818:Animals; D006801:Humans; D007700:Kinetics; D018832:Molecular Chaperones; D011487:Protein Conformation; D017510:Protein Folding
D018832:Molecular Chaperones