[Current therapeutic methods in primary sclerosing cholangitis].
The authors synthesize the main etiopathogenetic, physiopathologic and clinic findings of CSP and describe the pharmacs employed in the treatment of disease: corticosteroids, cyclosporin, penicillamine, colchicine, tacrolimus, metotrexate, hydrophylic bile salts. They outline the poor or none therapeutic activity of the majority of these and stress the improvement of some clinical parameters after prolonged use of hydrophilic bile salts. However none of the used pharmacs can stop the pathologic course of the disease. At the end authors remember the usefulness of liposoluble vitamins to prevent carential syndromes.
Raffa
S
S
Manzi
P
P
Sottili
S
S
Grassi
M
M
D001424:Bacterial Infections / Q000150:complications*; D001660:Biliary Tract Diseases / Q000382:microbiology*; D015209:Cholangitis, Sclerosing / Q000188:drug therapy* / Q000209:etiology; D003078:Colchicine / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D007154:Immune System Diseases / Q000150:complications; D008727:Methotrexate / Q000627:therapeutic use; D010396:Penicillamine / Q000627:therapeutic use
D016572:Cyclosporine; D010396:Penicillamine; D003078:Colchicine; D008727:Methotrexate