Pediatric neuro-AIDS. Update.
Vertically transmitted HIV-1 infection occurs in an immature developing organism. The maturational stage of the nervous and immune system when exposed to the direct or indirect effects of the virus is likely to be of utmost importance. Innumerable dynamic interactions occur between these two systems during development, and these undoubtedly interact in complex ways with HIV-1 variables. To care for these children and to design rational approaches for treatment and prevention, it is now critical to develop a better understanding of how HIV-1 affects the developing nervous system.
Belman
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Department of Neurology and Pediatrics, School of Medicine, State University of New York at Stony Brook, USA.
D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D000293:Adolescent; D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D018450:Disease Progression; D015658:HIV Infections / Q000151:congenital / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control / Q000635:transmission; D015497:HIV-1; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical