title: Is fibrin glue useful in preventing dialysate leakage in children on CAPD? Preliminary results of a prospective randomized study.
abstract: Children on continuous ambulatory peritoneal dialysis (CAPD) have a higher incidence of dialysate leakage than patients receiving cycler dialysis. To date, fibrin glue has been used to treat dialysate leakage but not as a method of prevention. Therefore, we conducted a prospective study in which 20 catheters were implanted in 19 children, with each catheter randomly assigned to either the treatment group (1 mL of fibrin glue added to peritoneal cuff suture) or the control group. There was no difference in mean patient age, elapsed time between catheter implantation and first catheter usage, and albumin concentration between the two groups. Dialysate leakage was detected in 4 patients in the control group, 3 of whom underwent early initiation of dialysis, but none of the patients in the treatment group (including 4 with early dialysis) had a similar problem. In summary, these preliminary data suggest that fibrin glue may be of benefit when applied at the time of catheter implantation. Further experience is necessary before this method can be routinely recommended.
authors.affiliation: Nephrology Department, Garrahan Hospital, Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Sojo
authors.forename: L
authors.initials: L
authors.lastname: Bisigniano
authors.forename: A
authors.initials: A
authors.lastname: Turconi
authors.forename: G
authors.initials: G
authors.lastname: Falke
authors.forename: M
authors.initials: M
authors.lastname: Grosman
authors.forename: N
authors.initials: N
authors.lastname: Delgado
authors.forename: M
authors.initials: M
authors.lastname: Bailez
mesh_terms: D000293:Adolescent; D002408:Catheters, Indwelling / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D015314:Dialysis Solutions; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008297:Male; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011446:Prospective Studies
chemical_list: D015314:Dialysis Solutions; D015718:Fibrin Tissue Adhesive