An 11-month-old with anti-glomerular basement membrane disease.
Anti-glomerular basement membrane antibody disease is an autoimmune disease that has rarely been described in children, and no cases have previously been described in a patient younger than 2.5 years of age. We report an 11-month-old infant girl who developed anti-glomerular basement membrane disease and progressed to end-stage renal disease and eventual renal transplantation. Although it has been suggested that this disease does not occur in infants, the possibility of anti-glomerular basement membrane disease must be considered in the differential diagnosis of acute renal failure and glomerulonephritis in an infant. The characteristic linear pattern of immunofluorescent studies for Immunoglobulin (Ig) G is important in suggesting the diagnosis, which can be confirmed by serologic testing for antibody titers.
Bigler
S A
SA
Department of Pathology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
Parry
W M
WM
Fitzwater
D S
DS
Baliga
R
R
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation; D010530:Peritoneal Dialysis; D010956:Plasmapheresis