title: Decreased habituation of midlatency auditory evoked responses in Parkinson's disease.
abstract: The P1 midlatency auditory evoked potential was studied in patients with Parkinson's disease and compared to that in age-matched controls. Habituation of the potential was determined by using a two-click stimulus paradigm in which the stimuli were presented at 250-, 500-, and 1,000-ms interstimulus intervals. Results showed that habituation of the P1 potential had a statistically significant decrease at the 250-ms and 500-ms interstimulus intervals in patients with Parkinson's disease compared to normal controls. The degree of decreased habituation was found to increase with severity of the disease such that stage 5 patients showed greater decreases in habituation compared to stage 4, as did stage 4 compared to stage 3. These findings may be explained by the presence of a dysregulation of sensory processing, possibly by elements of the reticular activating system, including the pedunculopontine nucleus, in Parkinson's disease.
authors.affiliation: Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
authors.forename: C
authors.initials: C
authors.lastname: Teo
authors.forename: L
authors.initials: L
authors.lastname: Rasco
authors.forename: K
authors.initials: K
authors.lastname: al-Mefty
authors.forename: R D
authors.initials: RD
authors.lastname: Skinner
authors.forename: F A
authors.initials: FA
authors.lastname: Boop
authors.forename: E
authors.initials: E
authors.lastname: Garcia-Rill
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011619:Psychotropic Drugs / Q000009:adverse effects; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D012720:Severity of Illness Index
chemical_list: D011619:Psychotropic Drugs