Genetics of histocompatibility.
Molecular studies of the major histocompatibility complex region, its genes, and its products are progressing in a number of different directions, and this progress is becoming of increasing interest not only to immunologists but also to geneticists and clinicians. Here I select only certain aspects of this field, stressing the biological importance of a few recent developments. This review concentrates on two topics of clinical importance and where important recent progress is reported: the "revolution" of HLA genotyping for histocompatibility matching in transplantation and the elucidation of a genetic disease of gene regulation, primary major histocompatibility complex class II deficiency (or bare lymphocyte syndrome).
Mach
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Department of Genetics and Microbiology, University of Geneva Medical School, Switzerland.
D000818:Animals; D017951:Antigen Presentation / Q000235:genetics; D014644:Genetic Variation; D006650:Histocompatibility Testing; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D014180:Transplantation