Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study.
OBJECTIVE
To evaluate the effect of low-dose aspirin use in oocyte donation recipients with an endometrial thickness of < 8 mm.


METHODS
A prospective, randomized study.


METHODS
An oocyte donation program in a private infertility practice.


METHODS
Twenty-eight recipients undergoing oocyte donation who failed to develop an endometrial thickness of at least 8 mm in a previous evaluation cycle.


METHODS
Fifteen recipients received low-dose aspirin (81 mg/d) in addition to standard hormone replacement for an oocyte donation cycle. The remaining 13 recipients did not receive aspirin.


METHODS
Clinical pregnancy rates, delivery rates, implantation rates, and change in endometrial thickness were compared in the aspirin and nonaspirin groups.


RESULTS
There was no demonstrable increase in endometrial thickness in the aspirin-treated group. However, there was a statistically significant increase in implantation rates in the aspirin-treated group (24% versus 9%) and in implantation rates and clinical pregnancy rates in the aspirin-treated group when the final endometrial thickness was < 8 mm.


CONCLUSIONS
Low-dose aspirin therapy improves implantation rates in oocyte donation recipients with a thin endometrium.
Weckstein
L N
LN
Reproductive Science Center of the Bay Area Fertility and Gynecology Medical Group, San Ramon, California, USA.
Jacobson
A
A
Galen
D
D
Hampton
K
K
Hammel
J
J
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000473:pathology*; D018587:Oocyte Donation; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011446:Prospective Studies
D001241:Aspirin