title: Cladribine (2-CDA) given as subcutaneous bolus injections is active in pretreated Waldenström's macroglobulinaemia. Swiss Group for Clinical Cancer Research (SAKK).
abstract: Clinical trials with intravenous cladribine infusions in pretreated patients with Waldenström's macroglobulinaemia have shown a response rate of 40%. Our pharmacokinetic studies revealed that the bioavailability of subcutaneous cladribine is complete but that the concentration-time profile is very different from intravenous administration. We designed this phase II multi-institutional trial to study the activity and toxicity of cladribine given as s.c. bolus injections in patients with symptomatic Waldenström's macroglobulinaemia. Between May 1993 and October 1995, 25 patients were accrued: male/female 18/7, median age 65 years (range 44-85). All except one patient had been pretreated with more than one regimen (median 2, range 0-10). 18 patients had progressed under previous therapy and six were in relapse. All patients received cladribine for a total dose of 0.5 mg/kg per cycle as s.c. bolus injections divided over 5 d at > or = 4 week intervals, for a maximum of six cycles. All 25 patients were evaluable for toxicity and response. A total of 67 cycles were administered (median 3 cycles, range 1-6). Overall response rate including disease stabilization which had been progressive under previous therapy was 68%. 10 patients (40%, 95% CI 21-61%) achieved a partial remission. Seven responders had been progressive under previous therapy. Maximum responses were reached no later than the third cycle. Median time to treatment failure and remission duration were 4.4 (range 0.5-33) and 8 months (5-29), respectively. Four patients (16%) suffered from infections W.H.O. grade > or = 2 (pneumonia grade 2, Staphylococcus septicaemia grade 3, viral encephalitis and pneumonia, both grade 4 with complete resolution). No other severe adverse events were observed. Cladribine given as s.c. 5 d bolus injections was found to be active in pretreated Waldenström's macroglobulinaemia and resulted in durable remissions.
authors.affiliation: Institute of Medical Oncology, Inselspital, Berne, Switzerland.
authors.forename: D C
authors.initials: DC
authors.lastname: Betticher
authors.forename: S F
authors.initials: SF
authors.lastname: Hsu Schmitz
authors.forename: D
authors.initials: D
authors.lastname: Ratschiller
authors.forename: A
authors.initials: A
authors.lastname: von Rohr
authors.forename: T
authors.initials: T
authors.lastname: Egger
authors.forename: P
authors.initials: P
authors.lastname: Pugin
authors.forename: M
authors.initials: M
authors.lastname: Stalder
authors.forename: U
authors.initials: U
authors.lastname: Hess
authors.forename: M F
authors.initials: MF
authors.lastname: Fey
authors.forename: T
authors.initials: T
authors.lastname: Cerny
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017338:Cladribine / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D009894:Opportunistic Infections / Q000150:complications; D013921:Thrombocytopenia / Q000139:chemically induced; D016896:Treatment Outcome; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D017338:Cladribine