title: Role and regulation of phospholipase D activity in normal and cancer cells.
abstract: PLD is regulated by the small GTP binding proteins Rho and Arf, though predominantly by the latter. The PA product of PLD activation is an activator of Rho-regulated actin stress fibre formation and in invasive cells of MMP-9 synthesis and activation. Together this may explain the increased invasion of cells in response to PA.
authors.affiliation: Institute for Cancer Studies, University of Birmingham, U.K.
authors.forename: M J
authors.initials: MJ
authors.lastname: Wakelam
authors.forename: A
authors.initials: A
authors.lastname: Martin
authors.forename: M N
authors.initials: MN
authors.lastname: Hodgkin
authors.forename: F
authors.initials: F
authors.lastname: Brown
authors.forename: T R
authors.initials: TR
authors.lastname: Pettitt
authors.forename: M J
authors.initials: MJ
authors.lastname: Cross
authors.forename: P G
authors.initials: PG
authors.lastname: De Takats
authors.forename: J L
authors.initials: JL
authors.lastname: Reynolds
mesh_terms: D020727:ADP-Ribosylation Factors; D000199:Actins / Q000378:metabolism; D015153:Blotting, Western; D002462:Cell Membrane / Q000201:enzymology; D002465:Cell Movement / Q000502:physiology; D004492:Edetic Acid / Q000494:pharmacology; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000378:metabolism* / Q000494:pharmacology; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism; D018922:HL-60 Cells; D006801:Humans; D008055:Lipids / Q000032:analysis; D008666:Metalloendopeptidases / Q000378:metabolism; D010712:Phosphatidic Acids / Q000378:metabolism / Q000494:pharmacology; D010739:Phospholipase D / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein
chemical_list: D000199:Actins; D008055:Lipids; D010712:Phosphatidic Acids; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D004492:Edetic Acid; D010739:Phospholipase D; D008666:Metalloendopeptidases; D019204:GTP-Binding Proteins; D020727:ADP-Ribosylation Factors; D020742:rhoA GTP-Binding Protein