title: Molecular evolution of RNA in vitro.
abstract: Experimental studies of RNA evolution in vitro are reviewed in the context of Eigen's 1971 theory and its subsequent extensions. Current research activity and future prospects for using automated molecular biology techniques for in vitro evolution experiments are surveyed.
authors.affiliation: Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
authors.forename: C K
authors.initials: CK
authors.lastname: Biebricher
authors.forename: W C
authors.initials: WC
authors.lastname: Gardiner
mesh_terms: D019143:Evolution, Molecular; D012313:RNA / Q000235:genetics*
chemical_list: D012313:RNA