[Renin-angiotension system--stress hormone response system].
Angiotensin II (A II) was significantly increased in both acutely and chronically stressed animals as found in brain, heart, blood vessels and adrenal glands. After running a race, the plasma A II contents of sportsmen similar to cortisol increased markedly too. In the chronical stress-hypertensive animals, the contents of circulating A II and tissue A II were increased quite lastingly. It was also found that the high concentration of A II may stimulate the adrenal gland secreting glucosteroid, and increase of tissue A II may be faciliated by the activation of beta adrenergic receptors. On basis of the above finding, we tend to assume that A II is a stress hormone and the renin angiotension system (RAS) is a stress hormone responses system. Morever there exists a close relation between RAS and two classic stress hormone response systems, i.e. the hypothalamus-pituitary-adrenal cortex system and the sympathetic-adrenal medulla system.
Wan
Y
Y
Department of Physiology, Hubei Medical University, Wuhan.
Yang
G
G
Wan
S X
SX
Yang
B
B
Ying
Y R
YR
Xi
Z X
ZX
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*; D012420:Running / Q000502:physiology; D013312:Stress, Physiological / Q000378:metabolism*
D000804:Angiotensin II; D006854:Hydrocortisone