title: Developmental changes in NMDA receptor expression in the platyfish brain.
abstract: We have examined the distribution of the N-methyl-D-aspartate (NMDA) receptor in the brain of a freshwater teleost using an antibody against the R1 subunit of the receptor (NMDAR1). The primary site of localization was the nucleus olfactoretinalis (NOR), a significant gonadotropin releasing hormone (GnRH)-containing brain nucleus. The number of cells expressing NMDAR1 in this nucleus was dependent upon developmental stage, with pubescent and mature animals displaying significantly more stained cells than immature and senescent animals. This is the first reported observation of age- and maturity-related NMDA receptor association with GnRH-containing brain areas.
authors.affiliation: The Graduate School and University Center of the City University of New York, NY, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Flynn
authors.forename: M P
authors.initials: MP
authors.lastname: Schreibman
authors.forename: L
authors.initials: L
authors.lastname: Magliulo-Cepriano
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D003532:Cyprinodontiformes / Q000254:growth & development*; D018507:Gene Expression Regulation, Developmental; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D009928:Organ Specificity; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D016194:Receptors, N-Methyl-D-Aspartate