title: Cholescintigraphy in the evaluation of bile flow after Roux-en-Y hepatico-jejunostomy and hepatico-antrostomy in infants with choledochal cysts.
abstract: BACKGROUND
  The study tests the hypothesis that stasis of bile in the Roux-en-Y hepatico-jejunostomy (RYJS) loop might facilitate biliary reflux and cause cholangitis, whereas quicker transit times in hepatico-antrostomy (HAST) might prevent cholangitis.
  
  
  METHODS
  Cholescintigraphy was performed using Tc99m-trimethyl-Br-IDA in seven RYJS patients and in five HAST patients.
  
  
  RESULTS
  The time to peak (Tmax) within the RYJS loop occurred between 18 and 50 min postinjection in all patients and the mean transit time (MTT) ranged between 42 and 69 min in 5/7 patients. Prolonged clearance of the tracer from the liver was seen in 2/7 RYJS patients, in whom the MTT was 77 and 240 min, respectively. In the HAST group, the Tmax within the anastomosed antrum occurred between 5 and 33 min postinjection, and the MTT ranged between 42 and 44 min in 2/5 patients. Protracted tracer uptake in the liver in one patient and localised tracer retention in the left hepatic bile ducts in 2/5 patients caused prolonged MTTs. Recurrent cholangitis and diarrhoea occurred in 4/7 RYJS patients, but in none of the HAST patients. Elevated gastrin levels after RYJS contrasted sharply to normal gastrin levels after HAST.
  
  
  CONCLUSIONS
  The findings on cholescintigraphy did not differ significantly between RYJS and HAST and provided no explanation for the distinctly different postoperative clinical course of both surgical methods. Nevertheless, we consider cholescintigraphy to be an efficient and cost-effective diagnostic modality for evaluation of the surgical outcome as regards biliary flow.
authors.affiliation: Department of Radiology, Division of Nuclear Medicine, University Hospital, Graz, Austria.
authors.forename: R M
authors.initials: RM
authors.lastname: Aigner
authors.forename: G F
authors.initials: GF
authors.lastname: Fueger
authors.forename: G
authors.initials: G
authors.lastname: Schimpl
authors.forename: H
authors.initials: H
authors.lastname: Sauer
authors.forename: R
authors.initials: R
authors.lastname: Nicoletti
mesh_terms: D000713:Anastomosis, Roux-en-Y; D000814:Aniline Compounds; D001646:Bile / Q000000981:diagnostic imaging* / Q000378:metabolism; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D015529:Choledochal Cyst / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005998:Glycine; D006801:Humans; D007098:Imino Acids; D007582:Jejunostomy; D008099:Liver / Q000601:surgery*; D008297:Male; D015609:Organotechnetium Compounds; D011184:Postoperative Period; D011706:Pyloric Antrum / Q000601:surgery; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013997:Time Factors
chemical_list: D000814:Aniline Compounds; D007098:Imino Acids; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C034837:technetium Tc 99m mebrofenin; D005998:Glycine