[An autoradiographic study of alpha 1-adrenoceptors in hepatic tissues in cirrhotic patients with portal hypertension].
We studied hepatic alpha 1-adrenoceptors of 8 hepatitis virus B-related cirrhotic patients with portal hypertension and 8 control surgical patients without liver disease by light radioautography. The density of alpha 1-adrenoceptors in various hepatic structures ("healthy" control vs. patients, per 10,000 microns 2) was as follows: on hypatocytes 1255.07 +/- 151.44/583.37 +/- 47.64 (P < 0.01); on intrahepatic artery walls 705.06 +/- 188.68/183.54 +/- 46.77 (P < 0.01); on intrahepatic portal walls 409.98 +/- 88.73/154.02 +/- 20.65 (P < 0.01); on hepatic venule walls 339.29 +/- 94.85/.... The decrease of density of alpha 1-adrenoceptors in cirrhotic liver tissues may be a result of the destruction of nomal hepatic structure by hepatitis virus B and the down-regulation of alpha 1-adrenoceptors.
Feng
H
H
Department of Surgery, People's Hospital, Beijing Medical University.
Leng
X
X
Xu
Q
Q
D001345:Autoradiography; D005260:Female; D006509:Hepatitis B; D006801:Humans; D006975:Hypertension, Portal / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000821:virology; D008297:Male; D008875:Middle Aged; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*
D018340:Receptors, Adrenergic, alpha-1