Polyenylphosphatidylcholine decreases alcoholic hyperlipemia without affecting the alcohol-induced rise of HDL-cholesterol.
In ethanol-fed rats, supplementation of the diet with soybean polyenylphosphatidylcholine (3 g/liter for 21 days) markedly decreased postprandial VLDL-triglycerides and both VLDL- and LDL-cholesterol levels, whereas it maintained high levels of HDL-cholesterol, compared to an equivalent intake of choline and polyunsaturated fatty acids. By contrast, there were no changes in the serum lipoproteins of the pair-fed controls. The prevention of alcoholic hypertriglyceridemia was associated with marked attenuation of the alcoholic fatty liver and it occurred despite a slight increase in fat absorption. Thus, the administration of polyenylphosphatidylcholine not only attenuates the hepatotoxicity of ethanol, but also increases the HDL/LDL cholesterol ratio, which may be beneficial for the prevention of atherosclerosis and coronary heart disease.
Navder
K P
KP
Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center, New York 10468, USA.
Baraona
E
E
Lieber
C S
CS
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood*; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity*; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced* / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008074:Lipoproteins / Q000097:blood; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D010713:Phosphatidylcholines; D014280:Triglycerides; C005152:lipostabil; D000431:Ethanol