title: The importance of cofactors in the histologic progression of minimal and mild chronic hepatitis C.
abstract: A follow-up liver biopsy was done 9-16 years (mean 12 years) after initial biopsy in 20 untreated Swedish patients infected with hepatitis C (8 men, 12 women; mean age 30 years at initial biopsy) in whom first biopsy had been classified as chronic persistent hepatitis. A significant progression of liver damage was found when using Histology Activity Index (HAI) scoring according to Knodell (p=0.006 for total HAI score; p=0.03 for grading, i.e., sum of HAI components 1, 2, and 3; p=0.01 for staging, i.e., HAI component 4, fibrosis). Fourteen of 20 (70%) patients had increased while 6 had decreased or unchanged HAI scores on follow-up biopsy. Occasional heavy alcohol drinkers (n=6) had an increased follow-up HAI score as compared with nondrinkers (p<0.05). Eight of 14 who deteriorated on follow-up versus 0 of 6 with improved or unchanged liver histology were anti-HBc positive (p=0.04). There was no significant correlation between HCV genotype and prognosis; however, the only two patients with liver cirrhosis on follow-up had genotype 1b. In conclusion, most patients with minimal or mild chronic hepatitis C in the present study had histologic progression on the latest biopsy. Cofactors such as alcohol abuse and exposure to hepatitis B may have a greater influence than HCV alone in determining the rate of deterioration of liver disease.
authors.affiliation: Department of Infectious Diseases, Ostra University Hospital, Göteborg, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Shev
authors.forename: A P
authors.initials: AP
authors.lastname: Dhillon
authors.forename: M
authors.initials: M
authors.lastname: Lindh
authors.forename: Z
authors.initials: Z
authors.lastname: Serléus
authors.forename: R
authors.initials: R
authors.lastname: Wejstål
authors.forename: A
authors.initials: A
authors.lastname: Widell
authors.forename: G
authors.initials: G
authors.lastname: Norkrans
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000473:pathology; D001706:Biopsy; D004279:DNA, Viral / Q000032:analysis; D018450:Disease Progression; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification; D006510:Hepatitis B Antibodies / Q000097:blood; D006515:Hepatitis B virus / Q000302:isolation & purification; D006526:Hepatitis C / Q000097:blood / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D006521:Hepatitis, Chronic / Q000097:blood / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D012367:RNA, Viral