title: Long-term efficiency of home nasal mask ventilation in patients with diffuse bronchiectasis and severe chronic respiratory failure: a case-control study.
abstract: The aim of this study was to evaluate long-term efficacy and tolerance of nasal mask ventilation (NMV) in a comparative case-control study. Fourteen patients with diffuse bronchiectasis and severe chronic respiratory failure (CRF), treated by long-term oxygen-therapy (LTO) and NMV, were case matched with 14 patients with diffuse bronchiectasis and severe CRF treated with only LTO. Patients and control subjects were compared based on the following parameters: blood gases, FEV1, vital capacity, hospitalizations, and survival. Symptoms, Karnofsky function score, and clinical evolution were also monitored in patients. Three subgroups may be identified according to outcome: two early deaths (subgroup 1), six patients with initial improvement and subsequent deterioration (subgroup 2), and six patients whose conditions remained improved for >2 years (subgroup 3). PaO2 decrease slope was slighter in this last subgroup than subgroup 2. The days of hospitalization were significantly reduced after institution of NMV in the patient group. Comparison between patients and control subjects did not show any difference on PaO2 evolution and on the overall median survival (46 and 40 months in NMV and control group, respectively). Long-term tolerance and compliance remained satisfactory for 11 patients. These results suggest that NMV is feasible as a long-term home treatment in patients with diffuse bronchiectasis. Although our results may have failed to prove a long-term efficiency on the course of blood gases and survival, a beneficial effect is observed with reduction of hospitalizations and improvement of functional status. This study warrants further investigation, in a prospective series, with a larger number of patients.
authors.affiliation: Service de Pneumologie CHU de Rouen and Etudes et Recherches en Pneumologie de l'Université de Rouen, France. muir@chu-rouen.fr
authors.forename: D
authors.initials: D
authors.lastname: Benhamou
authors.forename: J F
authors.initials: JF
authors.lastname: Muir
authors.forename: C
authors.initials: C
authors.lastname: Raspaud
authors.forename: A
authors.initials: A
authors.lastname: Cuvelier
authors.forename: C
authors.initials: C
authors.lastname: Girault
authors.forename: F
authors.initials: F
authors.lastname: Portier
authors.forename: J F
authors.initials: JF
authors.lastname: Menard
mesh_terms: D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D001987:Bronchiectasis / Q000097:blood / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016022:Case-Control Studies; D002908:Chronic Disease; D005500:Follow-Up Studies; D005540:Forced Expiratory Flow Rates; D006760:Hospitalization; D006801:Humans; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy / Q000295:instrumentation / Q000379:methods*; D011379:Prognosis; D012131:Respiratory Insufficiency / Q000097:blood / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome