title: Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
abstract: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
authors.affiliation: Division of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan. kuroo@ncnaxp.ncnp.go.jp
authors.forename: M
authors.initials: M
authors.lastname: Kuro-o
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumura
authors.forename: H
authors.initials: H
authors.lastname: Aizawa
authors.forename: H
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: T
authors.initials: T
authors.lastname: Suga
authors.forename: T
authors.initials: T
authors.lastname: Utsugi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohyama
authors.forename: M
authors.initials: M
authors.lastname: Kurabayashi
authors.forename: T
authors.initials: T
authors.lastname: Kaname
authors.forename: E
authors.initials: E
authors.lastname: Kume
authors.forename: H
authors.initials: H
authors.lastname: Iwasaki
authors.forename: A
authors.initials: A
authors.lastname: Iida
authors.forename: T
authors.initials: T
authors.lastname: Shiraki-Iida
authors.forename: S
authors.initials: S
authors.lastname: Nishikawa
authors.forename: R
authors.initials: R
authors.lastname: Nagai
authors.forename: Y I
authors.initials: YI
authors.lastname: Nabeshima
mesh_terms: D000375:Aging / Q000235:genetics* / Q000473:pathology; D000595:Amino Acid Sequence; D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics / Q000473:pathology; D001284:Atrophy; D002114:Calcinosis / Q000235:genetics / Q000473:pathology; D003001:Cloning, Molecular; D004646:Emphysema / Q000235:genetics; D005260:Female; D005835:Genitalia / Q000473:pathology; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D010024:Osteoporosis / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D010902:Pituitary Gland / Q000473:pathology; D017386:Sequence Homology, Amino Acid; D012867:Skin / Q000473:pathology; D013577:Syndrome; D013950:Thymus Gland / Q000473:pathology
chemical_list: D008565:Membrane Proteins