[Carcinoma of small neuroendocrine cells in major salivary glands. Presentation of two clinical cases and literature review].
To date, only 45 cases of oat cell carcinoma of the major salivary glands have been reported in the literature, which represents less than 1% of primary malignant tumors of the parotid glands. Two subtypes exist: ductal and neuroendocrine. We report two new cases of neuroendocrine oat cell carcinoma of the parotid gland which were treated by surgery associated with radiation therapy and chemotherapy. The literature review showed a predominance of males (61.7%), age 50-70 years, and location in parotid gland (83%). Treatment consists of radical surgery of the tumor associated with radiation therapy and chemotherapy. The prognosis is poor, with survivals at one, three and five years of 77.7%, 40.7%, and 29.6%, respectively, although this is better than the prognosis for other sites.
Frade González
C
C
Servicio de ORL, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela (La Coruña).
Lozano Ramírez
A
A
Cajade Frías
J
J
Mínguez Beltrán
I
I
Martín Martín
C
C
Labella Caballero
T
T
D000368:Aged; D018288:Carcinoma, Small Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology*