[Effect of yuxintong capsule on plasma endothelin and serum nitric oxide in acute myocardial ischemia dogs].
Effect of Yuxintong (YXT) capsule on plasma endothelin(ET), serum nitric oxide (NO) and creatine phosphokinase (CPK) activity in experimental acute myocardial ischemia dogs were observed. The results indicated that in acute myocardial ischemia dogs, the serum CPK activity and plasma ET level increased and serum NO level decreased significantly. In comparing with control, YXT not only could reduce significantly the increased plasma ET content and serum CPK activity, but also increase markedly the producing and releasing of NO, P < 0.05-0.001. Therefore, it could protect the myocardia from ischemic damage, the efficacy of YXT was positively dose dependent.
Lei
Y
Y
Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing.
Liu
J X
JX
Zhou
Y W
YW
D000818:Animals; D002214:Capsules; D003402:Creatine Kinase / Q000097:blood; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016232:Endothelins / Q000097:blood*; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D009569:Nitric Oxide; D003402:Creatine Kinase