Blood bank leukocyte infusions as remission induction therapy in a case of acute lymphoblastic leukemia.
A 15-year-old female with pre-pre B ALL in third relapse was treated with administration of eight blood bank leukocyte concentrates per day for 5 days. The total number of mononuclear cells per kilogram of weight was 4.89 x 10(8). On the fifth day of infusions the patient was in complete remission (CR), asymptomatic and with a normal CBC. No secondary effects were found. The patient remained in CR without treatment for 10 weeks before relapsing again. The possibility of reaching a short-lived, clinically relevant response, using blood bank leukocyte infusions, is a promising new approach for the treatment of leukemia.
Borbolla
J R
JR
Hematology Department, Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico City, Mexico.
López
M A
MA
Alvarado
M
M
Guzman
L
L
DeDiego
J
J
Trueba
E
E
González
M
M
Anaya
I
I
D000293:Adolescent; D001771:Blood Banks; D002051:Burkitt Lymphoma / Q000276:immunology / Q000628:therapy*; D005260:Female; D006087:Graft vs Host Reaction / Q000276:immunology; D006801:Humans; D016219:Immunotherapy, Adoptive; D017708:Leukocyte Transfusion