[Effect of Salvia miltiorrhiza on serum lipid peroxide, superoxide dismutase of the patients with coronary heart disease].
Twenty-four patients of coronary heart disease(CHD) were treated with Salvia miltiorrhiza (SM) and the change of SM on serum lipid peroxide (LPO), superoxide dismutase (SOD) after treatment were observed. The results were compared with that of control group consisted of 20 healthy persons, it showed that before treatment, the serum LPO of patient was significantly higher than that of control group and the SOD of patient was lower than that of healthy subjects (P < 0.01). After treated with SM, the LPO level decreased and SOD activity increased significantly. The mechanism might be correlated with the effect of SM in inhibiting platelets aggregation, reducing blood viscosity, improving myocardial ischemia and protecting cytomembrane. It suggested that SM could be regarded as a good exogenous scavenger of oxygen free radical.
Xing
Z Q
ZQ
People's Hospital of Yichun District, Jiangxi.
Zeng
X C
XC
Yi
C T
CT
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts; D027561:Salvia miltiorrhiza; D013482:Superoxide Dismutase / Q000097:blood*
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D010936:Plant Extracts; D013482:Superoxide Dismutase