The regional pattern of D4 gene expression in human brain.
Using a competitive reverse transcription-polymerase chain reaction (RT-PCR) assay levels of D4 gene expression have been determined in 16 regions obtained from a single control brain. Relatively high levels of expression were detected in the prefrontal and temporolimbic structures whilst low levels were detected in striatal regions. This pattern correlates with the reported distribution of the D4 receptor.
Mulcrone
J
J
Department Psychological Medicine, Institute of Psychiatry, London, UK. spkljam@mail.iop.bpmf.ac.uk
Kerwin
R W
RW
D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods*; D015870:Gene Expression; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D011954:Receptors, Dopamine / Q000235:genetics*; D014158:Transcription, Genetic
D011954:Receptors, Dopamine