[Changes of superoxide dismutase and lipid peroxide in lung tissue of rats after intratracheal injection of crocidolite and benzo(a) pyrene].
Wistar rats were divided into 4 groups: control group, Cro group, B(a) p group and Cro plus B(a) p group. Samples of lung tissue were collected 90, 180, 270, 360 and 540 days after the third time of intratracheal. The superoxide dismutase (SOD) activity, the level of lipid peroxide (LPO) and the ratio of SOD/LPO were observed. The results indicated that there was a synergistic action of Cro. and B(a) p.
Yang
Q
Q
Department of Pneumoconiosis, Chengdu.
Luo
S
S
Liu
X
X
Zhan
C
C
D000818:Animals; D017638:Asbestos, Crocidolite; D001564:Benzo(a)pyrene; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D007267:Injections; D008054:Lipid Peroxides / Q000378:metabolism*; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*
D008054:Lipid Peroxides; D017638:Asbestos, Crocidolite; D001564:Benzo(a)pyrene; D013482:Superoxide Dismutase