title: Treatment of penile intraepithelial neoplasia (PIN) with interferon alpha-2a, CO2 laser (vaporization) and 5-fluorouracil 5% (5-FU).
abstract: This study was undertaken to assess the effectiveness of CO2 laser (vaporization), 5-FU topical application and Interferon (IFN alpha-2a) parenterally in the therapy of penile intraepithelial neoplasia (PIN). From March 1986 to September 1991, 1,372 men, sexual partners of women with condylomata accuminata or flat or cervical intraepithelial neoplasia (CIN), were submitted to peoscopy, of 1,019 men who presented with various lesions caused by human papillomavirus (HPV)-confirmed histologically-208 were treated for PIN. The best treatment modalities irrespective of grade of lesion were found to be the combination of 5-FU plus CO2 laser vaporisation plus IFN alpha-2a (high dose) (96.15%), the combination of 5-FU plus CO2 laser vaporization (87.09%) and the combination of CO2 laser vaporization plus IFN alpha-2a (high dose) (80%). It is concluded that IFN alpha-2a (low dose) can be used as first line treatment in combination with 5-FU in patients with PIN II and as an adjuvant treatment (high dose) in patients with recurrent PIN I and PIN III.
authors.affiliation: Department of Obstetrics and Gynecology, University of Patras, Rio, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Cardamakis
authors.forename: K
authors.initials: K
authors.lastname: Relakis
authors.forename: P
authors.initials: P
authors.lastname: Ginopoulos
authors.forename: A
authors.initials: A
authors.lastname: Korantzis
authors.forename: K
authors.initials: K
authors.lastname: Metalinos
authors.forename: E
authors.initials: E
authors.lastname: Stathopoulos
authors.forename: Z
authors.initials: Z
authors.lastname: Papathanasiou
authors.forename: J
authors.initials: J
authors.lastname: Michopoulos
authors.forename: H
authors.initials: H
authors.lastname: Mantouvalos
authors.forename: I G
authors.initials: IG
authors.lastname: Kotoulas
authors.forename: V
authors.initials: V
authors.lastname: Tzingounis
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002245:Carbon Dioxide; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage; D053685:Laser Therapy; D008297:Male; D010412:Penile Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D010413:Penis / Q000473:pathology*; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D002245:Carbon Dioxide; D005472:Fluorouracil