Measurement of suberythema UVA radiation effects on skin by 31P magnetic resonance spectroscopy.
31P magnetic resonance spectroscopy (MRS) scans were obtained from the same anatomical location in four healthy Caucasian individuals before and after 1/2 MED UVA radiation. Suberythema UVA radiation induced in skin production of phosphomonoesters, phosphodiesters, and also depleted phosphocreatine and adenosine triphosphate (ATP). This data seems to indicate that 31P MRS is a sensitive enough technique to detect UVA induced changes in skin phosphometabolites. Furthermore, this data also appears to indicate that suberythema UVA radiation and dexamethasone induce in skin nearly identical pharmacodynamic effect.
Zemtsov
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Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Muncie, USA.
D000255:Adenosine Triphosphate / Q000032:analysis / Q000378:metabolism; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004890:Erythema / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010755:Organophosphates / Q000032:analysis / Q000378:metabolism; D010710:Phosphates / Q000032:analysis / Q000378:metabolism*; D010725:Phosphocreatine / Q000032:analysis / Q000378:metabolism; D010759:Phosphorus Isotopes; D010865:Pilot Projects; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays; D044465:White People
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D010755:Organophosphates; D010710:Phosphates; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D003907:Dexamethasone; D000255:Adenosine Triphosphate