L-Myc overexpression and detection of auto-antibodies against L-Myc in both the serum and pleural effusion from a patient with non-small cell lung cancer.
Non-small cell lung cancer patient was found to have auto-antibodies against L-Myc in both the serum and pleural effusion. The titer of anti-L-Myc antibodies was higher in the pleural effusion than in the serum. Overexpression of L-Myc without DNA amplification was observed in the tumor cells. L-Myc antigen was not detected in either the serum or the pleural effusion. Anti-nuclear antibodies were also detected in both the serum and pleural effusion, although this patient did not have collagen-vascular disease.
Yamamoto
A
A
Third Department of Internal Medicine, Tokushima University School of Medicine.
Shimizu
E
E
Sumitomo
K
K
Shinohara
A
A
Namikawa
O
O
Uehara
H
H
Sone
S
S
D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D014408:Biomarkers, Tumor; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015342:DNA Probes / Q000737:chemistry; D004273:DNA, Neoplasm / Q000276:immunology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016066:Pleural Effusion, Malignant / Q000097:blood / Q000276:immunology*; D016271:Proto-Oncogene Proteins c-myc / Q000276:immunology* / Q000378:metabolism*
D001323:Autoantibodies; D014408:Biomarkers, Tumor; D015342:DNA Probes; D004273:DNA, Neoplasm; D016271:Proto-Oncogene Proteins c-myc