Tissue injury in neutrophilic inflammation.
The exudation of neutrophils is the hallmark of a form of inflammatory response occurring after tissue colonization by invading bacteria or as an expression of various non-infectious diseases. All these diseases are characterized by a high risk of developing irreversible tissue injury. Neutrophil-endothelium interactions, activation-induced functional and structural changes of responding neutrophils, regulatory systems of neutrophil function, and oxidative-proteolytic pathways responsible for histotoxicity are reviewed here. Finally, perspectives for rational approaches to handle the development of tissue injury during neutrophilic inflammation are considered.
Dallegri
F
F
Department of Internal Medicine, University of Genova, Medical School, Italy.
Ottonello
L
L
D000893:Anti-Inflammatory Agents; D002448:Cell Adhesion; D002634:Chemotaxis, Leukocyte; D010450:Endopeptidases / Q000378:metabolism; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology* / Q000628:therapy; D009504:Neutrophils / Q000473:pathology* / Q000502:physiology; D016877:Oxidants
D000893:Anti-Inflammatory Agents; D016877:Oxidants; D010450:Endopeptidases