title: Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells.
abstract: Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B.
authors.affiliation: Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minnesota 55404, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Lokensgard
authors.forename: G
authors.initials: G
authors.lastname: Gekker
authors.forename: S
authors.initials: S
authors.lastname: Hu
authors.forename: A F
authors.initials: AF
authors.lastname: Arthur
authors.forename: C C
authors.initials: CC
authors.lastname: Chao
authors.forename: P K
authors.initials: PK
authors.lastname: Peterson
mesh_terms: D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000821:virology*; D002478:Cells, Cultured; D003975:Diazepam / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D016328:NF-kappa B / Q000187:drug effects
chemical_list: D014151:Anti-Anxiety Agents; D000956:Antigens, Viral; D016328:NF-kappa B; D003975:Diazepam