Pathogenesis and host defense in pulmonary infections.
The development of pneumonia typically results from an overwhelming bacterial inoculum or a breakdown in the integrity of the host's pulmonary defense mechanisms. Augmentation of pulmonary defenses is one means of reducing the incidence, morbidity, and mortality from pneumonia. Strategies to enhance pulmonary or systemic defenses are actively being investigated. Selected established and investigational measures enhancing host defense mechanisms against various pathogens are reviewed.
Mason
C M
CM
Louisiana State University Medical Center, New Orleans, USA.
Kolls
J K
JK
Nelson
S
S
D006801:Humans; D008168:Lung / Q000276:immunology; D018410:Pneumonia, Bacterial / Q000209:etiology / Q000276:immunology / Q000517:prevention & control; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology