[The pharmacokinetics of Kefzol in patients with acute pancreatitis when administered intravenously and endolymphatically].
Pharmacokinetics was studied of kefsole administered by intravenous and endolymphatic routes to patients (n = 23) with acute pancreatitis. The studies made showed that intravenous route for the drug administration makes for a quicker entering of the antibiotic into the peritoneal exudate. Apart from these reasons, endolymphatic antibacterial therapy does not appear to avert the development of complications involving pus-formation/discharging in acute pancreatitis and does not seem to be essential in the complex of therapeutic measures to be applied for treating the above patients.
Pugaev
A V
AV
Bogomolova
N S
NS
Bagdasarov
V V
VV
Sirozhitdinov
K B
KB
Vinogradova
L N
LN
D000208:Acute Disease; D001202:Ascitic Fluid / Q000378:metabolism; D002437:Cefazolin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D007272:Injections, Intralymphatic; D008196:Lymph / Q000378:metabolism; D010195:Pancreatitis / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors
D002511:Cephalosporins; D002437:Cefazolin