title: Increased cutaneous toxicity to ionizing radiation in HIV-positive patients. Military Medical Consortium for the Advancement of Retroviral Research (MMCARR).
abstract: BACKGROUND
  There are reports of increased reactions in HIV-1+ patients to ultraviolet light sometimes in association with medication. In addition, there are also reports of increased morbidity associated with radiation therapy in HIV-1+ patients.
  
  
  METHODS
  Three HIV-1+ patients developed cutaneous toxic reactions to radiation therapy; two with Kaposi's sarcoma (KS) and one with non-Hodgkin's lymphoma.
  
  
  CONCLUSIONS
  Although the mechanisms which resulted in these reactions are not clear, they may be related to depletion of endogenous scavengers and may be accentuated by the pattern of immune dysregulation present in HIV-1 disease.
authors.affiliation: National Naval Medical Center, Bethesda, Maryland, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Smith
authors.forename: H G
authors.initials: HG
authors.lastname: Skelton
authors.forename: S
authors.initials: S
authors.lastname: Tuur
authors.forename: J
authors.initials: J
authors.lastname: Yeager
authors.forename: C
authors.initials: C
authors.lastname: Decker
authors.forename: K F
authors.initials: KF
authors.lastname: Wagner
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects; D001932:Brain Neoplasms / Q000532:radiotherapy; D016371:Cranial Irradiation; D006679:HIV Seropositivity / Q000188:drug therapy / Q000503:physiopathology*; D015497:HIV-1; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology; D016483:Lymphoma, AIDS-Related / Q000532:radiotherapy; D008297:Male; D010787:Photosensitivity Disorders / Q000209:etiology*; D011855:Radiodermatitis / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D012514:Sarcoma, Kaposi / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000532:radiotherapy; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D019380:Anti-HIV Agents