The effects of a fluoroquinolone on the growth and development of infants.
Growth and development were monitored for up to 42 months in nine neonates to whom ciprofloxacin, a fluoroquinolone, was given in the neonatal period at a dosage of 20 mg/kg/day. Ciprofloxacin was used only as a ¿life-saving' therapy in cases of sepsis produced by bacterial agents resistant to other antibiotics. Two other groups of nine neonates, matched by birth weight and gestational age, were studied as controls: one group with sepsis, which was effectively treated with cefotaxime and a group of healthy neonates. No statistically significant differences in growth and development between the groups were found during follow-up for 42 months. No osteoarticular problems or joint deformities were observed in the ciprofloxacin group. Ciprofloxacin appears to provide a therapeutic option as a ¿life-saving' therapy for newborns with sepsis produced by multiply resistant organisms.
Gürpinar
A N
AN
Department of Paediatric Surgery, Uludağ University Faculty of Medicine, Bursa, Turkey.
Balkan
E
E
Kiliç
N
N
Kiriştioğlu
I
I
Doğruyol
H
H
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001827:Body Height / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002439:Cefotaxime / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006128:Growth / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007596:Joints / Q000187:drug effects / Q000502:physiology; D008297:Male; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology; D012720:Severity of Illness Index; D012886:Skull / Q000187:drug effects / Q000502:physiology
D000890:Anti-Infective Agents; D002511:Cephalosporins; D002939:Ciprofloxacin; D002439:Cefotaxime