Occurrence of ras mutations in human lung cancer. Minireview.
Members of ras family of oncogenes, when activated by a point mutation, have been implicated in many types of human cancers. In several types of human solid tumors, point mutations of the K-ras gene are relatively frequent. Among lung cancers, a subset of non-small cell lung carcinomas, mostly adenocarcinomas, contains activated K-ras. The examination of K-ras mutations in samples obtained for diagnostic reasons, such as bronchial biopsies or bronchoalveolar lavage fluid, may be used as a supplement in the early diagnosis of lung adenocarcinoma.
Vachtenheim
J
J
Laboratory of Molecular Biology, University Hospital, Bulovka, Czech Republic.
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D011905:Genes, ras; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009154:Mutation
D004273:DNA, Neoplasm