Direct HPLC separation of beta-aminoester enantiomers on totally synthetic chiral stationary phases.
The direct separation of beta-aminoester enantiomers by HPLC on synthetic chiral stationary phases based on a pi-acidic derivative of trans 1,2-diaminocyclohexane as selector is described. The application of different columns containing the stationary phase with opposite configurations and in the racemic form to the determination of enantiomeric excess in chemically impure samples is demonstrated.
Gasparrini
F
F
Dipartimento di Studi di Chimica e Technologia delle Sostanze Biologicamente Attive, Università La Sapienza, Roma, Italy.
D'Acquarica
I
I
Villani
C
C
Cimarelli
C
C
Palmieri
G
G
D000596:Amino Acids / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003514:Cyclohexylamines; D004952:Esters / Q000302:isolation & purification*; D013237:Stereoisomerism
D000596:Amino Acids; D003514:Cyclohexylamines; D004952:Esters; C030435:1,2-cyclohexanediamine