T-cell signaling: the importance of receptor clustering.
T-cell receptors bound to peptide-MHC molecules undergo higher-order oligomerization in solution. This observation, the low-affinity-recognition properties of T-cell receptors, and other indications that such receptors undergo rapid, serial engagement by a single ligand suggest a dynamic clustering model of T-cell signaling.
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Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1892, USA.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D015704:CD4 Antigens; D000949:Histocompatibility Antigens Class II; D011948:Receptors, Antigen, T-Cell