[Observations on signet cell invasion and metastasis in extra-mammary Paget's disease].
In order to evaluate the level of cell differentiation in extramammary Paget's disease (EMPD) and the relation with prognosis, the pathologic morphology of 20 EMPD cases were reviewed. We found two marked features of the invasive and metastatic Paget's cells: first, the Pagat cells were usually of signet ring shape; second, the cells formed gland-like structures. These features can be regarded as low differentiation and important risk factors for invasion and metastasis in EMPD.
Xu
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Department of Pathology, General Hospital of the PLA, Beijing.
Li
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N
Li
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W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005834:Genital Neoplasms, Male / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010145:Paget Disease, Extramammary / Q000473:pathology*; D010412:Penile Neoplasms / Q000473:pathology*; D012611:Scrotum; D014846:Vulvar Neoplasms / Q000473:pathology*