Advances in understanding the biology and function of the G-CSF receptor.
G-CSF is the major growth factor involved in the production of neutrophilic granulocytes. G-CSF exerts its function via the activation of a membrane receptor that belongs to the super-family of hematopoietin receptors, also referred to as class I cytokine receptors. In this review we summarize the current knowledge of the function of the G-CSF receptor in normal granulopoiesis, as well as in some patients with severe congenital neutropenia and acute myeloblastic leukemia, diseases characterized by disturbed myeloid maturation.
de Koning
J P
JP
Institute of Hematology, Erasmus University, Rotterdam, The Netherlands.
Touw
I P
IP
D000818:Animals; D006410:Hematopoiesis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D009503:Neutropenia / Q000151:congenital / Q000378:metabolism*; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000235:genetics / Q000378:metabolism*
D016188:Receptors, Granulocyte Colony-Stimulating Factor