Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa.
Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.
Köhler
T
T
Department of Genetics and Microbiology, Centre Médical Universitaire, Geneva, Switzerland. Thilo.Kohler@medecine.unige.ch
Michea-Hamzehpour
M
M
Plesiat
P
P
Kahr
A L
AL
Pechere
J C
JC
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000235:genetics; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D024841:Fluoroquinolones