GLP-1 (7-36) amide: effects on glucose transport and metabolism in rat adipose tissue.
In rat adipocytes, GLP-1 (7-36) amide induced an increment in 2-deoxy-glucose uptake, which was additive to that of insulin. Furthermore, in rat fat, GLP-1 (7-36) amide provoked a rise in glycogen synthesis, glucose oxidation and utilization and lipogenesis, the increments being lower than those obtained with insulin. These data support the idea that GLP-1 exerts insulin-like effects on glucose metabolism in rat adipose tissue, as it does in rat hepatocytes and skeletal muscle, although with a lower potency than that of insulin.
Perea
A
A
Department of Metabolism, Nutrition and Hormones, Foundación Jiménez Díaz, Madrid, Spain.
Viñambres
C
C
Clemente
F
F
Villanueva-Peñacarrillo
M L
ML
Valverde
I
I
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003847:Deoxyglucose / Q000378:metabolism; D005934:Glucagon; D052216:Glucagon-Like Peptide 1; D004763:Glucagon-Like Peptides; D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000096:biosynthesis; D007328:Insulin / Q000494:pharmacology; D008055:Lipids / Q000096:biosynthesis; D008297:Male; D010084:Oxidation-Reduction; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D007328:Insulin; D008055:Lipids; D010446:Peptide Fragments; C055453:glucagon-like peptide 1 (7-36)amide; D004763:Glucagon-Like Peptides; D052216:Glucagon-Like Peptide 1; D006003:Glycogen; D005934:Glucagon; D003847:Deoxyglucose; D005947:Glucose