Pharmacokinetics, foreign protein immune response, cytokine release, and lymphocyte subsets in patients receiving thymoglobuline and immunosuppression.
The pharmacokinetics and immune response to the rabbit IgG of rabbit antihuman thymocyte globulin, Thymoglobuline has been characterized. A cytokine release pattern of TNF alpha and IL-6 but not IL-1 beta and IFN chi has been demonstrated with the first and not subsequent doses. An effect on lymphocyte depletion of peripheral blood with major subset suppression has been shown to last more than the 3-month observation period in patients on a regimen of quadruple sequential immunosuppression.
Guttmann
R D
RD
McGill University Centre for Clinical Immunobiology and Transplantation, Montréal, Canada.
Caudrelier
P
P
Alberici
G
G
Touraine
J L
JL
D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology / Q000378:metabolism* / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism*; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology / Q000493:pharmacokinetics* / Q000494:pharmacology; D015850:Interleukin-6 / Q000097:blood; D016030:Kidney Transplantation / Q000276:immunology; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000961:Antilymphocyte Serum; D016207:Cytokines; D007166:Immunosuppressive Agents; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha