title: Intestinal disease in acquired immunodeficiency: evaluation by CT.
abstract: Intestinal symptoms affect most AIDS patients at some point in their disease. The purpose of this study was to evaluate the use of CT in this setting. A total of 339 abdominal CT exams were reviewed for signs of intestinal disease. Abdominal CT scans of 45 patients with intestinal symptoms were compared with colonoscopy and histologic data. The CT results were correlated with CD4( +) T-lymphocyte counts and patient survival. More than 14 % of all abdominal CT exams displayed signs of enteric disease. Of the 45 patients studied with both CT and colonoscopy, 35 (78 %) had signs of intestinal disease by CT. Of these 35 patients, colonoscopic signs of an intestinal lesion were found in 29 and histologic proof of disease was established in 30 cases. Colonoscopy and histology detected 8 lesions missed by CT. There were 14 cases of unspecific colitis, 15 cases of cytomegalovirus (CMV) colitis, and 4 cases of enteric tuberculosis as per biopsy. Five patients presented with Kaposi's sarcoma and 1 with a non-Hodgkin's lymphoma. Neither colonoscopic nor CT signs of intestinal disease did reliably distinguish between histologic subgroups. Specifically, CMV colitis could not be distinguished from unspecific colitis. CD4( +) T-lymphocyte counts for histologic subgroups were not significantly different, either. No colonoscopic or histologic feature predicted survival, whereas low CD4 counts and ascites on CT indicated a poor prognosis. Whereas CT detects signs of intestinal disease in most AIDS patients, these signs remain largely unspecific. Colonoscopy and biopsies provide no consistently valid standard with which to compare CT because of controversial sensitivity and specificity of these methods. The CT technique detects small bowel as well as extraintestinal disease. Therefore, CT is an important diagnostic modality in abdominal disease of immunocompromised patients.
authors.affiliation: Strahlenklinik und Poliklinik, Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität, Augustenburger Platz 1, D-13 353 Berlin, Germany.
authors.forename: F D
authors.initials: FD
authors.lastname: Knollmann
authors.forename: T
authors.initials: T
authors.lastname: Grünewald
authors.forename: A
authors.initials: A
authors.lastname: Adler
authors.forename: J
authors.initials: J
authors.lastname: Mäurer
authors.forename: R E
authors.initials: RE
authors.lastname: Hintze
authors.forename: H D
authors.initials: HD
authors.lastname: Pohle
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000368:Aged; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D007422:Intestines / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed