The effect of alpha-trinositol on cholera toxin-induced fluid accumulation in pig (Sus scrofa domesticus) jejunum in vivo.
The effect of alpha-trinositol (D-myo-inositol-1,2,6-trisphosphate) on cholera toxin-induced fluid accumulation (i.e., net fluid secretion) was studied in the pig jejunum in vivo. Cholera toxin caused a dose-dependent fluid accumulation in control experiments. Intravenous injection of alpha-trinositol produced a reduction of the response to cholera toxin with a significant maximal inhibition of 36%. However, in high concentrations of alpha-trinositol this inhibition was absent.
Tindholdt
T T
TT
Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Hansen
M B
MB
Elbrønd
V S
VS
Makinde
M
M
Westerberg
E J
EJ
Skadhauge
E
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001826:Body Fluids / Q000378:metabolism*; D002772:Cholera Toxin / Q000037:antagonists & inhibitors*; D005260:Female; D007295:Inositol Phosphates / Q000494:pharmacology*; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism; D008954:Models, Biological; D013552:Swine / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007295:Inositol Phosphates; D002772:Cholera Toxin; C059368:atrinositol