The published DNA sequence of human cytomegalovirus strain AD169 lacks 929 base pairs affecting genes UL42 and UL43.
Compared with the published DNA sequence (M. S. Chee, et al. Curr. Top. Microbiol. Immunol. 154:125-170, 1990), most isolates of human cytomegalovirus strain AD169 contain an additional 929 bp after nucleotide 54612. This results in a changed reading frame for the 5'-terminal 50 codons of gene UL42 and expansion of gene UL43 (a US22 family member) from 187 (3'-truncated) to 423 (full-length) codons. The UL42 and UL43 gene products are nonessential for growth in culture.
Dargan
D J
DJ
MRC Virology Unit, University of Glasgow, United Kingdom. d.dargan@vir.gla.ac.uk
Jamieson
F E
FE
MacLean
J
J
Dolan
A
A
Addison
C
C
McGeoch
D J
DJ
D000595:Amino Acid Sequence; D001482:Base Composition; D001483:Base Sequence; D003587:Cytomegalovirus / Q000235:genetics* / Q000302:isolation & purification; D004279:DNA, Viral; D015246:Deoxyribonuclease EcoRI / Q000378:metabolism; D017353:Gene Deletion; D005814:Genes, Viral; D016679:Genome, Viral; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D015183:Restriction Mapping; D017384:Sequence Deletion; D014764:Viral Proteins / Q000235:genetics*
D004279:DNA, Viral; D014764:Viral Proteins; D015246:Deoxyribonuclease EcoRI