title: [An experimental study of the cardiovascular activity of nistranol].
abstract: In concentrations of > or = 10(-5) mol/liter nistranol (11 beta-nitroxy-9 alpha-hydroxy-ethynylestradiol-diacetate) demonstrated cardiac and vascular activity in vitro. It caused concentration-dependent and reversible increase of the contractile parameters of an isolated atrial appendage of rats. A three-phase effect of nistranol on a isolated rat thoracic aorta was encountered: vasodilatation-vasoconstriction-vasodilatation. Anti-ischemic and antinecrotic effects of nistranol were noted in experimental myocardial infarction.
authors.forename: P V
authors.initials: PV
authors.lastname: Sergeev
authors.forename: A N
authors.initials: AN
authors.lastname: Karachentsev
authors.forename: S A
authors.initials: SA
authors.lastname: Isaeva
authors.forename: A Zh
authors.initials: AZh
authors.lastname: Mambetova
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002319:Cardiovascular System / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D045166:Estradiol Congeners / Q000494:pharmacology* / Q000627:therapeutic use; D004997:Ethinyl Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy; D017202:Myocardial Ischemia / Q000188:drug therapy; D051381:Rats
chemical_list: D002316:Cardiotonic Agents; D045166:Estradiol Congeners; C108508:nistranol; D004997:Ethinyl Estradiol