Increased S100beta in the cerebrospinal fluid of patients with frontotemporal dementia.
Levels of S100beta, a calcium-binding protein found in astrocytes, were measured using a sandwich ELISA in the cerebrospinal fluid (CSF) of patients with frontotemporal dementia and Alzheimer's disease and compared with controls. Mean CSF S100beta concentrations were significantly raised in patients with frontotemporal dementia when compared with healthy controls (0.49 +/- 0.28 vs. 0.22 +/- 0.08 ng/ml, P < 0.001). There was no correlation between age at disease onset, disease severity or length of illness. The increased concentration of CSF S100beta seen in frontotemporal dementia may reflect the marked astrocytosis seen in this condition.
Green
A J
AJ
Department of Neuroimmunology, National Hospital for Neurology and Neurosurgery, London, UK. agreen@ion.ucl.ac.uk
Harvey
R J
RJ
Thompson
E J
EJ
Rossor
M N
MN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D001253:Astrocytes / Q000473:pathology; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000473:pathology; D003704:Dementia / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors; D012189:Retrospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000134:cerebrospinal fluid*; D013702:Temporal Lobe / Q000473:pathology
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins