title: The efficacy of interferon alpha on colchicine-resistant familial Mediterranean fever attacks: a pilot study.
abstract: About a quarter of familial Mediterranean fever (FMF) patients have recurrent painful attacks of polyserositis despite regular colchicine treatment. There is no known alternative drug for colchicine-resistant cases. We had previously observed a patient with FMF whose painful attacks disappeared during the 6 month period of interferon alpha (IFN) treatment for his chronic hepatitis B. The objective of the present study was to investigate the possible beneficial effect of IFN on these episodes. Twenty-one consecutive attacks in seven adult patients with FMF were treated at early onset with IFN, the dosage being 3-10 million I U s.c. Eighteen of the 21 attacks could be halted in a mean time of 3.05 h, while the intensity of abdominal pain remained very low. Observed side-effects were generally mild and acceptable. IFN may be a useful adjunct for the treatment of colchicine-resistant attacks in FMF patients.
authors.affiliation: Department of Internal Medicine, Dokuz Eylül University School of Medicine, Balçova, Izmir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Tunca
authors.forename: E
authors.initials: E
authors.lastname: Tankurt
authors.forename: H
authors.initials: H
authors.lastname: Akbaylar Akpinar
authors.forename: S
authors.initials: S
authors.lastname: Akar
authors.forename: N
authors.initials: N
authors.lastname: Hizli
authors.forename: O
authors.initials: O
authors.lastname: Gönen
mesh_terms: D000328:Adult; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003078:Colchicine; D004351:Drug Resistance; D010505:Familial Mediterranean Fever / Q000276:immunology / Q000628:therapy*; D005260:Female; D006074:Gout Suppressants; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage*; D007958:Leukocyte Count; D008297:Male; D010865:Pilot Projects; D010976:Platelet Count
chemical_list: D006074:Gout Suppressants; D016898:Interferon-alpha; D002097:C-Reactive Protein; D003078:Colchicine