title: Wave-speed-determined flow limitation at peak flow in normal and asthmatic subjects.
abstract: The purpose of this study was to examine whether peak expiratory flow is determined by the wave-speed flow-limiting mechanism. We examined 17 healthy subjects and 11 subjects with stable asthma, the latter treated with inhaled bronchodilators and corticosteroids. We used an esophageal balloon and a Pitot-static probe positioned at five locations between the right lower lobe and midtrachea to obtain dynamic area-transmural pressure (A-Ptm) curves as described (O. F. Pedersen, B. Thiessen, and S. Lyager. J. Appl. Physiol. 52: 357-369, 1982). From these curves we obtained cross-sectional area (A) and airway compliance (Caw = dA/dPtm) at PEF, calculated flow at wave speed (Vws = A[A/(Caw*rho)0.5], where rho is density) and speed index is (SI = V/Vws). In 13 of 15 healthy and in 4 of 10 asthmatic subjects, who could produce satisfactory curves, SI at PEF was > 0.9 at one or more measured positions. Alveolar pressure continued to increase after PEF was achieved, suggesting flow limitation somewhere in the airway in all of these subjects. We conclude that wave speed is reached in central airways at PEF in most subjects, but it cannot be excluded that wave speed is also reached in more peripheral airways.
authors.affiliation: Department of Environmental and Occupational Medicine, University of Aarhus, Denmark. ofp@mil.aau.dk
authors.forename: O F
authors.initials: OF
authors.lastname: Pedersen
authors.forename: H J
authors.initials: HJ
authors.lastname: Brackel
authors.forename: J M
authors.initials: JM
authors.lastname: Bogaard
authors.forename: K F
authors.initials: KF
authors.lastname: Kerrebijn
mesh_terms: D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D005260:Female; D006801:Humans; D008170:Lung Compliance / Q000502:physiology; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000502:physiology; D011650:Pulmonary Alveoli / Q000502:physiology; D012044:Regression Analysis; D012129:Respiratory Function Tests; D013147:Spirometry; D014797:Vital Capacity / Q000502:physiology