[Serum soluble CD8 and soluble interleukin-2-receptor levels during interferon therapy in chronic hepatitis C].
We examined the relationship between the changes of serum soluble CD8 (sCD8) and soluble interleukin-2 receptor (sIL-2R) levels and effectiveness of interferon (IFN) in patients with chronic hepatitis (CH) C. Changes in sCD8 levels were parallel with fluctuations of alanine aminotransferase (ALT) in CH patients during IFN treatment but decreases of sCD8 levels were slower than those of ALT. In IFN effective and ALT decreased patients sCD8 levels is also decreased. sIL-2R levels was increased transiently during administration of IFN in most cases. It was suggested that decrease in sCD8 levels is indicative of the effectiveness of IFN therapy.
Maekawa
H
H
Department of Clinical Laboratories, Kyorin University Hospital, Mitaka.
Ishiyama
N
N
Furuya
N
N
Nakahara
K
K
Saito
S
S
Uchimura
H
H
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016827:CD8 Antigens / Q000097:blood*; D005260:Female; D019698:Hepatitis C, Chronic / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012995:Solubility
D015415:Biomarkers; D016827:CD8 Antigens; D016898:Interferon-alpha; D015375:Receptors, Interleukin-2