[Immunohistochemical study of endothelin-1 in adrenal tumors].
10 cases of aldosteronoma, 10 cases of pheochromocytoma and 10 cases of adrenocortical adenoma and hyperplasia were studied by using immunohistochemical staining for ET-1. All of the tumors were stained positivily for ET-1, ranging from weak diffuse (+) staining to moderate staining (++). In aldosteronomas ET-1 receptro may be down-regulated and ET-1 may play a paracrine role in regulating catecholamine in pheochromocytoma.
Yang
D
D
PUMC Hospital, CAMS, Beijing.
Zeng
Z
Z
Gu
J
J
Chen
J
J
Wang
Y
Y
D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000737:chemistry / Q000378:metabolism; D000310:Adrenal Gland Neoplasms / Q000737:chemistry*; D018246:Adrenocortical Adenoma / Q000737:chemistry; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000378:metabolism; D019332:Endothelin-1 / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000737:chemistry
D019332:Endothelin-1; D000450:Aldosterone