[The determination of the optimal irradiation dose in the tumor tissue-normal body tissues system].
To estimate the optimal cancerocidal dose, it is necessary to construct the mathematical models describing the probability of radiation sterilization of tumor tissue and that of a radiation-induced complication in the selected system of normal tissues or in the particular normal tissue if its radiosensitivity is higher than that of other tissues. The optimal cancerocidal dose may be estimated while solving a special emergency problem from the proposed criterion by taking into account the limited probabilities of radiation-induced complications in normal organs and tissues if they are damaged.
Klepper
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D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy; D008433:Mathematics; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000517:prevention & control*; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage