Study on the detection of leprosy reactions and the effect of prednisone on various nerves, Indonesia.
This paper presents a retrospective study on the detection of the treatment of leprosy reactions in a field situation, and the effect of prednisone on the various affected nerves. Two patient cohorts were analysed. The leprosy control programme in the testing area is not backed up by a specialized referral leprosy hospital, but patients are treated on an ambulatory basis at peripheral health centres by trained multipurpose health workers supervised by the health centre doctors. For operational purposes the guidelines and procedures for reaction management in the field were adjusted and partially simplified. In both studies it appeared that the time of the occurrence of severe reactions was the same: 80% or more of the severe reactions occurred in the first year of treatment, the majority in the first few months after the start of the multidrug (MDT) treatment. One third of all reaction patients suffered from a silent neuritis. Well-instructed fieldworkers proved to be competent in detecting and treating leprosy reactions. Treatment of severe reactions with prednisone in the field situation can preserve or considerably improve the functions of the affected nerves. It is interesting that often the motor function of a nerve was found to be impaired without any loss in sensibility, which was tested using the ballpoint pen method.
Bernink
E H
EH
Provincial Department of Health, Section Communicable Diseases, Palu/Sulteng, Indonesia.
Voskens
J E
JE
D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007214:Indonesia; D007917:Leprostatic Agents / Q000627:therapeutic use; D007918:Leprosy / Q000188:drug therapy*; D010525:Peripheral Nerves / Q000187:drug effects* / Q000473:pathology; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use*; D012189:Retrospective Studies
D000893:Anti-Inflammatory Agents; D007917:Leprostatic Agents; D011241:Prednisone