title: Making agonists of antagonists.
abstract: Cell-surface receptors can be divided into three classes, depending on whether they transmit information by allosteric conformational change, by receptor dimerization, or by receptor aggregation. So far, only the first class of receptors has proven readily accessible to chemical techniques; this is no accident, but times are changing.
authors.affiliation: Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: B
authors.initials: B
authors.lastname: Seed
mesh_terms: D000818:Animals; D006801:Humans; D008968:Molecular Conformation; D011956:Receptors, Cell Surface / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D011956:Receptors, Cell Surface