The functional transformation of cytotoxic lymphocytes into T-suppressors under the influence of two mediators.
A set of CTL-lines in the system differing in the whole H-2 complex, as well as in distinct subregions of H-2, was established. These lines were routinely tested in Cr51-release assay to insure that they retained lytic activity and antigen-specificity. The result of the interaction of CTL with H-2Kb-molecule and alpha1-thymosine was transition of CTL into a reversible state of anergy. A high concentration of alpha1-thymosine is necessary for this transition. Anergic CTL caused specific suppressor activity that is functional if transformation of CTL into T-suppressors took place.
Anfalova
T V
TV
Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russia. kazansky@paragraph.com
Galaktionov
V G
VG
Brondz
B D
BD
D000818:Animals; D017635:Clonal Anergy; D006183:H-2 Antigens / Q000494:pharmacology*; D064532:Histocompatibility Antigen H-2D; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology
D006183:H-2 Antigens; C032876:H-2Kb protein, mouse; D064532:Histocompatibility Antigen H-2D; D013947:Thymosin; D000077596:Thymalfasin