title: Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene.
abstract: We have mapped the human ORFX gene to chromosome 9q34 and determined its complete gene structure. Comparison with RING3, the human MHC-linked homologue on 6p21.3, shows the two gene structures to be highly conserved but with an approximate threefold expansion in the ORFX introns. RING3 and ORFX are found to be ubiquitously expressed in human adult and foetal tissues. Evidence suggests that the two genes may have arisen from an ancient duplication in a common ancestral chromosome.
authors.affiliation: The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
authors.forename: K L
authors.initials: KL
authors.lastname: Thorpe
authors.forename: P
authors.initials: P
authors.lastname: Gorman
authors.forename: C
authors.initials: C
authors.lastname: Thomas
authors.forename: D
authors.initials: D
authors.lastname: Sheer
authors.forename: J
authors.initials: J
authors.lastname: Trowsdale
authors.forename: S
authors.initials: S
authors.lastname: Beck
mesh_terms: D000328:Adult; D001483:Base Sequence; D001665:Binding Sites; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D016384:Consensus Sequence; D017124:Conserved Sequence; D005333:Fetus; D008040:Genetic Linkage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D008285:Major Histocompatibility Complex; D016328:NF-kappa B / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis* / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics*; D014157:Transcription Factors; D014158:Transcription, Genetic; D000092468:Bromodomain Containing Proteins
chemical_list: D016328:NF-kappa B; D017346:Protein Serine-Threonine Kinases; D016601:RNA-Binding Proteins; D014157:Transcription Factors; C098415:BRD2 protein, human; D000092468:Bromodomain Containing Proteins; C109106:BRD3 protein, human