[The changes of glucocorticoid receptor and beta-adrenoreceptor of lung tissues in SD rat asthma models and the effects of antiasthmatics on them].
OBJECTIVE
To observe the changes of glucocorticoid receptor (GR) and beta-adrenoreceptor (beta-AR) of lung tissue and the effects of oral procaterol, salbutamol and intraperitoneal (i.p.) or inhaled (i.h.) dexamethasone (Dex).


METHODS
The GR or beta-AR were determined by using 3H-dexamethasone and 3H-Dihydroalprenolol as ligand respectively, in groups of rat asthma models at 1, 3, 7, 14th day and groups received antiasthmatics on the 7th day after daily consecutive challenges.


RESULTS
The GR Bmax of asthma groups increased significantly after the first challenge, but decreased since the third day to a lower level than that of healthy control. The KD also decreased significantly since the third day. The beta-AR Bmax of asthma group gradually decreased to a significant low level on the 14th day. The Dex i.p. group had the lowest GR Bmax and the Dex i.h. group had the highest beta-AR Bmax among the treated. In the procaterol and salbutamol group, there had no decrease of GR Bmax compared with that of controls.


CONCLUSIONS
The GR and beta-AR levels of lung tissues changed after daily challenges. The GC played a down-regulation role on GR and an up-regulation role on beta-AR in lung tissues. The Dex i.h. had more advantages than Dex i.p. in terms of GR and beta-AR regulations.
Lü
G
G
304th Hospital of PLA, Beijing.
Cui
D
D
Guo
Y
Y
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001249:Asthma / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D008168:Lung / Q000378:metabolism; D008297:Male; D017265:Procaterol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
D000318:Adrenergic beta-Agonists; D005938:Glucocorticoids; D011943:Receptors, Adrenergic, beta; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D017265:Procaterol