title: Charged with meaning: the structure and mechanism of phosphoprotein phosphatases.
abstract: Many phosphatases require two metal ions for catalysis. New structural information on two serine/threonine phosphatases offers insight into how the metals contribute to catalysis. A comparison with the structures of protein tyrosine phosphatases, which do not use metal ions, shows that the only similarity at the active site is that of charge.
authors.affiliation: Department of Chemistry, Indiana University, Bloomington 47405, USA.
authors.forename: W P
authors.initials: WP
authors.lastname: Taylor
authors.forename: T S
authors.initials: TS
authors.lastname: Widlanski
mesh_terms: D001665:Binding Sites; D002384:Catalysis; D008670:Metals / Q000737:chemistry* / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D008670:Metals; D010749:Phosphoprotein Phosphatases