The effect of Padma-28, a traditional Tibetan herbal preparation, on human neutrophil function.
Human neutrophils were studied in vitro in the presence of the herbal preparation Padma-28. At concentrations higher than 0.3 mg/ml, the Padma-28 induced O2- production in unstimulated neutrophils. At lower concentrations, O2- production was inhibited in phorbol myristate acetate (PMA) stimulated cells. Lysozyme release by PMA and opsonized zymosan-stimulated cells was inhibited by Padma-28 at a concentration dependent manner. On the other hand, random and directed migration and adhesion to nylon fibers were not affected. These results suggest that Padma-28 may have anti-inflammatory activity whose mechanism remains to be elucidated.
Matzner
Y
Y
Hematology Unit, Hadassah University Hospital, Mount Scopus, Israel.
Sallon
S
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D015550:Cell Degranulation / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008516:Medicine, Chinese Traditional; D009113:Muramidase / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism; D018609:Tibet
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D013481:Superoxides; C066069:Padma 28; D009113:Muramidase