title: Clinical antecedents of neurologic and audiologic abnormalities in survivors of neonatal extracorporeal membrane oxygenation.
abstract: Extracorporeal membrane oxygenation is an effective rescue treatment for severe cardiorespiratory failure in term or near term neonates, although cerebral palsy, mental retardation, and sensorineural hearing loss are observed in 10 to 20% of survivors. The objective of the present study was to identify potential risk factors that may explain the neurologic and audiologic sequelae noted in 19% of 181 survivors of neonatal extracorporeal membrane oxygenation from our hospital. Our results suggest the following findings in survivors of severe cardiorespiratory failure treated with neonatal extracorporeal membrane oxygenation: (1) hypotension or the need for cardiopulmonary resuscitation before extracorporeal membrane oxygenation significantly increases the risk of spastic cerebral palsy, (2) profound hypocarbia before extracorporeal membrane oxygenation is associated with a significantly increased risk of hearing loss, (3) mental retardation in the absence of spastic cerebral palsy is unexplained except when due to abnormal fetal brain development, and (4) hypoxemia in the absence of hypotension does not increase the risk of neurologic or audiologic sequelae.
authors.affiliation: Department of Pediatrics, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Graziani
authors.forename: S
authors.initials: S
authors.lastname: Baumgart
authors.forename: S
authors.initials: S
authors.lastname: Desai
authors.forename: C
authors.initials: C
authors.lastname: Stanley
authors.forename: M
authors.initials: M
authors.lastname: Gringlas
authors.forename: A R
authors.initials: AR
authors.lastname: Spitzer
mesh_terms: D001921:Brain / Q000254:growth & development; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects; D002547:Cerebral Palsy / Q000209:etiology*; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D007022:Hypotension / Q000150:complications; D000860:Hypoxia; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000209:etiology*; D008297:Male; D012307:Risk Factors; D016896:Treatment Outcome