Can prenylcysteines be exploited as ligands for mammalian multidrug-resistance transporters?
The overexpression of specific transport proteins in the membrane of many cancer cells renders these cells resistant to many therapeutic drugs. Some lipid-modified cysteine compounds inhibit one drug-transporting protein, indicating the potential of developing such compounds as therapeutic agents.
Hurwitz
L M
LM
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham NC 27710-3686, USA.
Casey
P J
PJ
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D003545:Cysteine / Q000378:metabolism*; D018432:Drug Resistance, Multiple; D006801:Humans; D008024:Ligands; D017368:Protein Prenylation
D018528:ATP-Binding Cassette Transporters; D008024:Ligands; D003545:Cysteine