title: Neuroleptic intolerance.
abstract: This article reviews antipsychotic medication side effects, especially those that require the physician to discontinue or the patient to be noncompliant with otherwise useful medication. They include such common problems as extrapyramidal syndromes (dystonia, akathisia, drug-induced Parkinsonism, tardive dyskinesia), sedation, weight gain, and sexual dysfunction, as well as less frequent concerns, such as seizures, neuroleptic malignant syndrome, agranulocytosis, torsade de pointes, hepatitis, and dermatological and ophthalmological syndrome. The adverse events associated with some of the new antipsychotic drugs are included. Available information about individual susceptibility to side effects is addressed by syndrome.
authors.affiliation: Portland VA Medical Ctr., OR 97207, USA.
authors.forename: T E
authors.initials: TE
authors.lastname: Hansen
authors.forename: D E
authors.initials: DE
authors.lastname: Casey
authors.forename: W F
authors.initials: WF
authors.lastname: Hoffman
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D006801:Humans; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D010349:Patient Compliance; D012559:Schizophrenia / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced; D016171:Torsades de Pointes / Q000139:chemically induced
chemical_list: D014150:Antipsychotic Agents