Gene silencing: cosuppression at a distance.
When a plant carries a transgenic copy of an endogenous gene, both genes may be silenced. This 'cosuppression' can occur not only within individual cells, but also in distant cells through an agent that apparently moves through the plant's phloem.
Smyth
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Department of Genetics and Developmental Biology, Monash University, Clayton, Melbourne, Victoria 3168, Australia. david.smyth@sci.monash.edu.au
D000818:Animals; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D010942:Plant Viruses / Q000235:genetics; D010947:Plants, Toxic; D012323:RNA Processing, Post-Transcriptional; D013489:Suppression, Genetic; D014026:Nicotiana / Q000201:enzymology / Q000235:genetics; D019076:Transgenes