[Meningitis after acute Borrelia burgdorferi infection in HIV infection].
METHODS
A 39-year-old HIV positive patient developed myalgia, headache and cough 4 weeks after a tick bite. His temperature was 37.4 degrees C and a circular pale erythema was noted over the left lower leg.


METHODS
C-reactive protein was raised to 120 mg/l, white blood cell count was 5860/microliter, CD4-lymphocyte count 250/microliter. The chest radiogram showed pneumonitic infiltration in the left lower lobe. There were IgM antibodies against Borrelia burgdorferi.


METHODS
Left lower lobe pneumonia and chronic erythema migrans were diagnosed and he was given oral azithromycin (500 mg on the first day and 250 mg for 4 days). The pneumonia cleared up, but 2 weeks later he developed symptoms of meningitis (496 cells per microliter, 87% lymphocytes, positive Borrelia burgdorferi antibody titer), which quickly and lastingly responded to ceftriaxon (2 g daily by brief infusion for 14 days).


CONCLUSIONS
This immune-compromised HIV-infected patient developed disseminated borreliosis with CNS involvement 2 weeks after the occurrence of chronic erythema migrans. The initial treatment of the latter with azithromycin was unable to prevent the meningitis. It is unlikely that there was a causal connection between the borreliosis and the pneumonia.
Dudle
G
G
Abteilung Infektionskrankheiten und Spitalhygiene, Universitätsspital Zürich.
Opravil
M
M
Lüthy
R
R
Weber
R
R
D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D017963:Azithromycin / Q000627:therapeutic use; D015748:Borrelia burgdorferi Group; D002443:Ceftriaxone / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D007075:Immunoglobulin M / Q000097:blood; D007299:Insect Bites and Stings; D008193:Lyme Disease / Q000150:complications* / Q000175:diagnosis; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology; D013987:Ticks
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D002511:Cephalosporins; D007075:Immunoglobulin M; D002443:Ceftriaxone; D017963:Azithromycin