title: Altered skin microcirculation in patients with systemic lupus erythematosus.
abstract: Although microvasculitis is one of the more common manifestations of systemic lupus erythematosus, there is no data on the hemodynamics of the skin microcirculation in such patients. The combination of dynamic capillaroscopy measuring capillary blood cell velocity (CBV) and laser Doppler fluxmetry (LDF) was used to simultaneously evaluate the nutritional and the total skin microcirculation in the fingers of 24 consecutive patients with SLE, using normal matched subjects as controls. The nutritional skin flow, as assessed by the CBV, was significantly impaired in patients, as compared with controls, both at rest (p = 0.001) and during postocclusive reactive hyperemia (p = 0.006). By contrast, no differences were observed in total skin microcirculation, as assessed by LDF (n.s.). There was no significant correlation between hemodynamic parameters and the presence of Raynaud's phenomenon, morphological capillary changes or anticardiolipine antibodies. There was no correlation between the magnitude of the alteration of the capillary blood flow and capillary morphological abnormalities, suggesting that the microvascular damage might be caused by different pathophysiological mechanisms.
authors.affiliation: Division of Angiology and Hemostasis, University Hospital of Geneva, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Bongard
authors.forename: P A
authors.initials: PA
authors.lastname: Miescher
authors.forename: H
authors.initials: H
authors.lastname: Bounameaux
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D002196:Capillaries / Q000648:ultrastructure; D016022:Case-Control Studies; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008180:Lupus Erythematosus, Systemic / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D011928:Raynaud Disease / Q000473:pathology / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply*