title: Mycobacteremia in patients with the acquired immunodeficiency syndrome.
abstract: BACKGROUND
  Bacillemia is a key event in the pathogenesis of tuberculosis. Although current evidence indicates that Mycobacterium tuberculosis bacteremia is rare in patients seronegative for the human immunodeficiency virus, it has been increasingly reported in patients with the acquired immunodeficiency syndrome (AIDS).
  
  
  OBJECTIVE
  To determine clinical and laboratory characteristics of patients with AIDS and tuberculosis with and without bacillemia.
  
  
  METHODS
  Fifty patients with AIDS with clinical suspicion of disseminated mycobacterial disease were prospectively selected. Three consecutive blood samples were collected for culture using a standardized protocol.
  
  
  RESULTS
  Mycobacterium was isolated from any body site in 42 patients (84%). Bacillemia was detected in 30 (71.4%) of these 42 patients: 11 (28.2%) caused by Mycobacterium avium-intracellulare complex and 19 (71.8%) caused by M tuberculosis. Blood culture was the only method used to confirm the diagnosis in 5 (15%) of the 33 tuberculosis cases. Tuberculosis in patients with AIDS developed with nonspecific insidious symptoms, a remarkable elevated alkaline phosphatase level, and without the classic miliary radiological pattern. We could demonstrate 2 previously unrevealed clinical characteristics of bacteremic tuberculosis in patients with AIDS: a shift to the left in the white blood cell count and abdominal lymph node enlargement. In patients with tuberculosis, the in-hospital mortality rate was higher among patients with bacillemia, although the posttreatment survival rate was comparable.
  
  
  CONCLUSIONS
  Blood culture is a valuable tool to confirm the clinical diagnosis of disseminated tuberculosis in patients with AIDS and can distinguish patients with characteristic clinical findings and outcome. Abdominal ultrasonography may be an additional helpful tool to identify these patients.
authors.affiliation: Evandro Chagas Hospital, Rio de Janeiro, Brazil.
authors.forename: B
authors.initials: B
authors.lastname: Grinsztejn
authors.forename: F C
authors.initials: FC
authors.lastname: Fandinho
authors.forename: V G
authors.initials: VG
authors.lastname: Veloso
authors.forename: E C
authors.initials: EC
authors.lastname: João
authors.forename: M C
authors.initials: MC
authors.lastname: Lourenço
authors.forename: S A
authors.initials: SA
authors.lastname: Nogueira
authors.forename: L S
authors.initials: LS
authors.lastname: Fonseca
authors.forename: E
authors.initials: E
authors.lastname: Werneck-Barroso
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000328:Adult; D016470:Bacteremia / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D015269:Mycobacterium avium Complex / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000000981:diagnostic imaging / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D011446:Prospective Studies; D011859:Radiography; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging / Q000382:microbiology