title: [Efficacy of nasal bi-level positive airway pressure ventilation in a patient with olivo-ponto-cerebellar atrophy suffering from sleep apnea syndrome].
abstract: Sleep apnea with neuromuscular disorders has been successfully treated with bi-level positive airway pressure ventilation (BiPAP), which, unlike continuous positive airway pressure ventilation (CPAP), creates pressure difference between expiratory and inspiratory phases. Hence if the respiration of patients stops longer than a pre-set duration, BiPAP can automatically force them to breath through a nasal mask. We report a 60-year-old woman with olivo-ponto-cerebellar atrophy (OPCA), whose mixed-type sleep apnea was difficult to treat with conventional CPAP. We therefore tried BiPAP on this patient at night. Nocturnal CO2 retention was nearly resolved, and unexpectedly daytime PaCO2 was also corrected with marked improvement of daytime somnolence. BiPAP is totally non-invasive, and may be one of the most effective treatments in patients with OPCA suffering from sleep apnea.
authors.affiliation: Department of Neurology, Neurological Institute, Tokyo Women's Medical College.
authors.forename: M
authors.initials: M
authors.lastname: Iijima
authors.forename: K
authors.initials: K
authors.lastname: Ota
authors.forename: M
authors.initials: M
authors.lastname: Ubano
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Iwata
mesh_terms: D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000209:etiology / Q000628:therapy; D007385:Intermittent Positive-Pressure Ventilation / Q000295:instrumentation; D008875:Middle Aged; D009849:Olivopontocerebellar Atrophies / Q000150:complications*; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000628:therapy*