Structural studies of natural product biosynthetic proteins.
The first high-resolution structures of key proteins involved in the biosynthesis of several natural product classes are now appearing. In some cases, they have resulted in a significantly improved mechanistic understanding of the often complex processes catalyzed by these enzymes, and they have also opened the way for more rational efforts to modify the products made.
Townsend
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Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA. townsend@jhunix.hcf.jhu.edu
D000818:Animals; D018360:Crystallography, X-Ray; D009097:Multienzyme Complexes / Q000096:biosynthesis / Q000737:chemistry; D010088:Oxidoreductases / Q000096:biosynthesis / Q000737:chemistry; D010406:Penicillins / Q000096:biosynthesis; D014176:Protein Biosynthesis; D011506:Proteins / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism
D009097:Multienzyme Complexes; D010406:Penicillins; D011506:Proteins; D013729:Terpenes; D010088:Oxidoreductases; C038370:isopenicillin N synthetase