Immunoresponses of humanized SCID mice to human lung cancer cells.
HuPBL-SCID mice were used to explore how they would response to human tumor cells of 801/MLC. Living 801/MLC cells appeared to be fetal to the the mice due to the production of human TNF. The huPBL-SCID mice did not generate any noticeable amount of specific human immunoglobulin either by single immunization with living 801/MLC cells or by repeated immunization with irradiated 801/MLC cells. Our preliminary experiments with huPBL-SCID mice showed that such chimeras would be a very useful models for tumor immunological researches.
Chen
L
L
Institute of Basic Medical Sciences, CAMS & PUMC, Beijing.
Wang
S
S
Zhang
Y
Y
Wang
S
S
D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007136:Immunoglobulins / Q000097:blood; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D018183:Transplantation Chimera / Q000276:immunology*; D014407:Tumor Cells, Cultured / Q000528:radiation effects; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007136:Immunoglobulins; D014409:Tumor Necrosis Factor-alpha