[Significance of argyrophil staining for nucleolar organizer regions (AgNORs) to pathologic diagnosis of prostatic adenocarcinoma].
Argyrophil staining method for nucleolar organizer regions (AgNORs) was used in 7 patients with well-differentiated prostatic adenocarcinoma (PAC) and tissue-surrounded adenocarcinoma (TSC) and 20 patients with prostatic hyperplasia (PH). The mean count of AgNORs of PAC was 4.322 +/- 0.269, and the mean area of nucleolus 6.236 +/- 2.199 microns2 its largest diameter was 2.1 microns and its size and shape showed some deformity. The mean count of AgNORs of tissue-surrounded PAC and PH was 1.820 +/- 0.683 and 2.284 +/- 0.383 respectively. The mean area of their nucleolus was 1.892 +/- 0.146 microns2 and 1.673 +/- 0.216 microns2. The largest diameter was the same 1.1 microns. Statistically, there was highly significant between PH and TSC (P > 0.05). The study revealed that the changes of size of nucleolus and AgNORs count are significant in pathologic diagnosis and differential diagnosis of PAC.
Cao
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Nanhai City Hospital, Guangdong.
D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology*; D016622:Silver Staining