[The effect of the iontophoretic application of acetylcholine to the neurons of the rabbit motor cortex on the functioning of the intracortical connections].
The multiunit activity of the neurons in the motor cortex was recorded in 8 rabbits under conditions of acetylcholine (or physiological saline) iontophoretic application. Crosscorrelation analysis of pulse trains was carried out. It was found out that acetylcholine activated the intracortical connections. Its application led to an increase in intensity of permanently existing short-latency interneuronal connections (i.e. the stable ones). Moreover, it led to a formation of the long-latency unstable connections. However, the obtained data do not suggests that acetylcholine promotes the formation of new short-latency connections between neurons. The modulatory influence of acetylcholine is discussed on the network activity of cortical neurons.
Khokhlova
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D000109:Acetylcholine / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D016009:Chi-Square Distribution; D007478:Iontophoresis; D008839:Microelectrodes; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology
D000109:Acetylcholine