title: Recurrence rates of excised keloids treated with postoperative triamcinolone acetonide injections or interferon alfa-2b injections.
abstract: BACKGROUND
  Keloids that are surgically removed commonly recur within the excision sites.
  
  
  OBJECTIVE
  Our purpose was to determine whether postsurgical adjunctive therapy reduces such recurrences.
  
  
  METHODS
  We determined the rate of recurrence after excision alone (n = 43) and postoperative injection with triamcinolone acetonide (TAC; n = 65) or interferon alfa-2b (IFN-alpha 2b; n = 16).
  
  
  RESULTS
  Of lesions excised without postoperative injections, 51.1% (22 of 43) recurred; 58.4% of TAC-treated lesions (38 of 65) recurred and 18.7% of IFN-alpha 2b-treated lesions (3 of 16) recurred (p = 0.025).
  
  
  CONCLUSIONS
  Postoperative TAC injections do not reduce the number of keloid recurrences. However, injection of keloid excision sites with IFN-alpha 2b offers a therapeutic advantage over keloid excision.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL 33136, USA.
authors.forename: B
authors.initials: B
authors.lastname: Berman
authors.forename: F
authors.initials: F
authors.lastname: Flores
mesh_terms: D000293:Adolescent; D000328:Adult; D017024:Chemotherapy, Adjuvant; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D007627:Keloid / Q000188:drug therapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011994:Recombinant Proteins; D012008:Recurrence; D012189:Retrospective Studies; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D014222:Triamcinolone Acetonide