[Results after an in vitro fertilization pregnancy. French National Register on In Vitro Fertilization].
For this analysis, all the oocyte recoveries realised between 1989, January 1st and 1995, December 31th and collected by the French national register on IVF (FIVNAT) were included. Three groups were constituted, depending on the existence of a previous birth (group 1, n = 8,615), or of a previous failed pregnancy (spontaneous abortion or ectopic pregnancy, group 2, n = 8,539), both obtained by IVF, or no previous IVF pregnancy (group 3, n = 139,843). In this last group, women and men were of younger age (respectively 33.3 +/- 4.7 vs 35.1 +/- 3.9 for group 1 and 34.3 +/- 4.5 for group 2, p < 0.001, and 35.2 +/- 5.9 vs 37.0 +/- 5.1 for group 1 and 36.1 +/- 5.6 for group 2, p < 0.001). Overall results were lower in the group 3. The average number of embryos was 3.7 +/- 3.7 compared to 4.4 +/- 3.8, p < 0.001 for the two other groups. The fertilization rates was at 47.3 +/- 33.2% in group 3, compared to 55.5 +/- 30.5 in group 1 and 55.6 +/- 30.4 in group 2 (p < 0.001). Finally, the per recovery pregnancy rates were respectively 17.9%, 28.0%, 25.0% (p < 0.001). In group 3, infertility origin was less often due to a tubal disease (53.2% vs 65.6% in group 1 and 66.6% in group 2, p < 0.001). On the opposite, an isolated male origin was more frequent (respectively 19.9%, 11.0% and 12.2%) (p < 0.001). In group 3, compared with those with secondary infertility, women with primary infertility were younger (32.6 +/- 4.6 vs 34.7 +/- 4.6, p < 0.001), had more oocytes (8.9 +/- 5.7 vs 8.1 +/- 5.4, p < 0.001), but less embryos (3.6 +/- 3.7 vs 3.9 +/- 3.7, p < 0.001), a decreased fertilization rate (44.8 +/- 33.4 vs 51.6 +/- 32.6, p < 0.001) and a decreased pregnancy rate (17.3% vs 18.9%, p < 0.01). Infertility was more often of male origin (23.6% vs 11.7%, p < 0.001).
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D005602:France; D006801:Humans; D008297:Male; D008423:Maternal Age; D010298:Parity; D010331:Paternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D012042:Registries