Carbimazole induced agranulocytosis: rescue with human recombinant granulocyte colony stimulating factor.
We report on a 25 yr old woman with primary autoimmune hyperthyroidism who was treated with carbimazole. Forty-three days later she developed agranulocytosis (64 x 10(6)/l). With 4 days treatment with recombinant human Granulocyte Colony Stimulating factor the granulocyte count rose to normal--4,350 cells x 10(6)/l. This is considerably faster than the rate of spontaneous recovery which usually takes one to 2 weeks.
O'Hare
J A
JA
Department of Medicine, Limerick Regional General Hospital, Dooradoyle.
Azher
T
T
D000284:Administration, Oral; D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000628:therapy; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002231:Carbimazole / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D011994:Recombinant Proteins; D013971:Thyrotoxicosis / Q000188:drug therapy*
D013956:Antithyroid Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D002231:Carbimazole