Previous intravenous chemotherapy does not alter response rate or survival time of patients with hepatic metastases from colorectal cancer treated by hepatic artery chemotherapy.
BACKGROUND
The present paper addressed the issue of whether pretreatment with intravenous (i.v.) chemotherapy affects response rate or survival in patients receiving hepatic artery chemotherapy (HAC).


METHODS
Case note reviews of 164 patients treated in a teaching hospital from June 1990 to July 1996 were carried out.


RESULTS
The response rate and carcino-embryonic antigen (CEA) fall in the two groups was almost identical. There was a nonsignificant survival advantage in the non-pretreatment group.


CONCLUSIONS
Previous administration of i.v. chemotherapy did not affect the CEA response of patients receiving HAC.
Morris
D L
DL
University of New South Wales Department of Surgery, St. George Hospital, Kogarah, Australia.
Zhao
J
J
Clingan
P R
PR
D000931:Antidotes / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D005472:Fluorouracil / Q000008:administration & dosage*; D006499:Hepatic Artery / Q000187:drug effects*; D006801:Humans; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000556:secondary*; D015996:Survival Rate
D000931:Antidotes; D000964:Antimetabolites, Antineoplastic; D002272:Carcinoembryonic Antigen; D002955:Leucovorin; D005472:Fluorouracil