title: Selective defect of baroreflex blood pressure buffering with intact cardioinhibition in a woman with familial aniridia.
abstract: We report a symptomatic failure of the baroreceptor blood pressure (BP) buffering mechanism in a woman with familial aniridia. Her baseline BP oscillated at 0.1 Hz, the frequency of Mayer waves, with increased amplitude on standing without orthostatic hypotension. Although sudomotor function was normal, cutaneous thermoregulatory function and BP response to Valsalva's maneuver were abnormal. The defective BP buffer mechanism suggests Mayer waves could be a sympathetic mediated cardiovascular resonance. Baroreceptor cardioinhibition was intact. We presume that the lesion is in the rostral aspect of the dorsal medulla oblongata.
authors.affiliation: Peripheral Nerve and Autonomic Unit, Southern General Hospital, Glasgow, U.K.
authors.forename: P O
authors.initials: PO
authors.lastname: Julu
authors.forename: M O
authors.initials: MO
authors.lastname: McCarron
authors.forename: S
authors.initials: S
authors.lastname: Hansen
authors.forename: A
authors.initials: A
authors.lastname: Barnes
authors.forename: G A
authors.initials: GA
authors.lastname: Jamal
authors.forename: J P
authors.initials: JP
authors.lastname: Ballantyne
mesh_terms: D000328:Adult; D015783:Aniridia / Q000235:genetics* / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000503:physiopathology; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014636:Valsalva Maneuver