title: The tumor suppressor protein p16INK4a.
abstract: The tumor suppressor protein p16INK4a (inhibitor of CDK4) is one of the most direct links between cell-cycle control and cancer. The p16INK4a gene is frequently inactivated in human tumors, and inheritance of mutant alleles results in susceptibility to several types of cancer. p16INK4a is part of a cell-cycle regulatory pathway that converges in the tumor suppressor protein Rb. The mechanisms that regulate p16INK4a are starting to be characterized.
authors.affiliation: Department of Immunology and Oncology, Centro Nacional de Biotecnología, CSIC, Madrid, Spain. mserrano@cnb.uam.es
authors.forename: M
authors.initials: M
authors.lastname: Serrano
mesh_terms: D000483:Alleles; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D019942:Genes, p16; D006801:Humans; D008322:Mammals; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology*; D011506:Proteins / Q000235:genetics; D016160:Retinoblastoma Protein / Q000502:physiology; D025803:Tumor Suppressor Protein p14ARF
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D011506:Proteins; D016160:Retinoblastoma Protein; D025803:Tumor Suppressor Protein p14ARF; D018844:Cyclin-Dependent Kinases