[Sexual and gonadal dysfunction in adrenal disorders].
Among various diseases of the adrenals, major disorders that cause sexual and gonadal disturbances are congenital adrenal hyperplasia(CAH) and Cushing's syndrome, and the others include virilizing or feminizing adrenocortical tumors. CAH was reviewed based on the recent advances in molecular genetics. The most striking discovery was steroidogenic acute regulatory protein, mutations of which produce lipoid adrenal hyperplasia that was previously attributed to P-450scc deficiency. Reversible amenorrhea or impotence is found in patients with Cushing's syndrome. Low plasma estrogen and testosterone levels are associated with female and male patients, respectively. Elevated adrenal androgen accounts for mild virilization in female patients with ACTH-dependent subtypes. The sites of action at which hypercortisolemia suppresses the hypothalamic-pituitary-gonadal axis were discussed.
Horiba
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Department of Medicine, Hirosaki University School of Medicine.
D000306:Adrenal Cortex Neoplasms / Q000150:complications; D000307:Adrenal Gland Diseases / Q000150:complications*; D000312:Adrenal Hyperplasia, Congenital / Q000150:complications; D003480:Cushing Syndrome / Q000150:complications; D012734:Disorders of Sex Development / Q000209:etiology*; D005260:Female; D006058:Gonadal Disorders / Q000209:etiology*; D006801:Humans; D008297:Male; D020018:Sexual Dysfunctions, Psychological / Q000209:etiology