Paradoxical hyperfixation of hexamethylpropyleneamine oxime in cerebral infarction.
We describe four patients with cerebral infarction and 99mTc-hexamethylpropyleneamine oxime (HMPAO) hyperfixation in distributions corresponding to the infarctions seen at CT and/or MR imaging. Increased HMPAO extraction due to hyperpermeability across the blood-brain barrier and increased retention due to reduced back diffusion of the tracer probably accounted for the increased fractional fixation in infarcts seen in our patients.
Shintani
S
S
Department of Neurology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan.
Tsuruoka
S
S
Shiigai
T
T
D000368:Aged; D001812:Blood-Brain Barrier / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000097:blood / Q000000981:diagnostic imaging*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D019690:Technetium Tc 99m Exametazime / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon
D019690:Technetium Tc 99m Exametazime