title: Effect of postnatal exposure to a PCB mixture in monkeys on multiple fixed interval-fixed ratio performance.
abstract: Behavioral impairment as a consequence of PCB exposure beginning in utero has been reported in both humans and animals. The present study assessed the behavioral consequences of postnatal exposure to PCBs. Male monkeys (Macaca fascicularis) were dosed from birth to 20 weeks of age with 7.5 microgram(s)/kg/day of a PCB mixture representative of the PCBs typically found in human breast milk (eight monkeys) or vehicle (four monkeys). At 4 years of age, performance under a multiple fixed interval (FI)-fixed ratio (FR) schedule of reinforcement was assessed. The FI component was more sensitive to disruption as a result of PCB exposure than was the FR component. PCB-exposed monkeys displayed shorter mean interresponse times (IRTs) than controls, particularly during the earlier sessions of the experiment. Similarly, the increase in pause time characteristic of the acquisition of typical FI performance emerged more slowly across sessions in the PCB-treated group. However, the number of short IRTs (less than 5 s) remained greater in the treated group compared to controls over the 48-session duration of the experiment. On the FR component, control monkeys decreases the mean pause time across sessions whereas the PCB-treated group did not; there were no differences between groups for absolute value of average IRT or pause time. The results of this study extend previous research in this cohort of monkeys, and provide further evidence that PCB exposure limited to the early postnatal period and resulting in environmentally relevant body burdens produces long-term behavioral effects.
authors.affiliation: Toxicology Research Division, Health Canada, Ottawa, Ontario, Canada. drice@bcad1.food.hwc.ca
authors.forename: D C
authors.initials: DC
authors.lastname: Rice
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects*; D008252:Macaca fascicularis; D008297:Male; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D012055:Reinforcement Schedule
chemical_list: D011078:Polychlorinated Biphenyls