Assessment of possible protective roles of selenium, zinc, and cis-stilbene oxide against acute T-2 toxin poisoning: a preliminary report.
The efficacy of two free radical scavengers, selenium and zinc, and a microsomal epoxide hydrolase-inducing agent, cis-stilbene oxide on the acute toxicity of T-2 toxin, a potent cytotoxic trichothecene, was investigated. Mice were pretreated daily for 3 consecutive days with either zinc sulfate (4.4 mg/kg, intraperitoneally [i.p.]), sodium selenite (1, 2, and 3 mg/kg i.p.) or cis-stilbene oxide (50 mg/kg i.p.). A full 24-hr after the final dosing with these agents, mice were given T-2 toxin (2, 2.5, or 3 mg/kg i.p.). The acute lethal toxicity of T-2 toxin (2.5 mg/kg) was reduced by administration of only sodium selenite (3 mg/kg) and cis-stilbene oxide (50 mg/kg). No significant effect on weight gain was observed.
Yazdanpanah
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H
Department of Pharmacology and Toxicology, School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran. hrasekh@neda.net
Roshanzamir
F
F
Shafaghi
B
B
Faizi
M
M
Elhami
M
M
Rasekh
H R
HR
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004851:Epoxide Hydrolases / Q000378:metabolism; D016166:Free Radical Scavengers / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000201:enzymology; D011041:Poisoning / Q000517:prevention & control; D012643:Selenium / Q000627:therapeutic use*; D013267:Stilbenes / Q000627:therapeutic use*; D013605:T-2 Toxin / Q000633:toxicity*; D015032:Zinc / Q000627:therapeutic use*
D016166:Free Radical Scavengers; D013267:Stilbenes; D004851:Epoxide Hydrolases; D012643:Selenium; D013605:T-2 Toxin; D015032:Zinc; C025906:stilbene oxide