Determination of the distribution of malathion in rats following various routes of administration by whole-body electronic autoradiography.
The distribution of [14C]-malathion, an organophosphorus pesticide, in rats after intravenous, oral and dermal administration was carried out using electronic autoradiography of whole body sections of treated animals. The study indicated that a major difference in the disposition of [14C]-malathion occurred following various routes of administration to rats. Following intravenous administration, the liver and kidney accumulated extremely high levels of the chemical. After oral administration, [14C]-malathion absorption from the stomach was slow and its excretion followed mostly the fecal route. Dermal application of [14C]-malathion may represent a high risk for exposure to the organophosphorus pesticide where the entire skin, not only the site of application, may act as reservoir for the compound.
Saleh
M A
MA
Department of Chemistry, Texas Southern University, Houston 77004, USA. mahmoud-saleh@classic.msn.com
Ahmed
A E
AE
Kamel
A
A
Dary
C
C
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography / Q000379:methods*; D004582:Electronics, Medical; D007275:Injections, Intravenous; D007306:Insecticides / Q000493:pharmacokinetics*; D008294:Malathion / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D007306:Insecticides; D008294:Malathion