title: Association of carotid arterial distensibility with Doppler indices of left ventricular filling in 50-year-old subjects.
abstract: Doppler indices of left ventricular diastolic filling are associated with various cardiac and extracardiac factors. Afterload is one of the extracardiac factors influencing left ventricular diastolic filling. The distensibility of the great arteries is one of the components of afterload. In this study, the relation between Doppler indices of left ventricular filling and the distensibility of the common carotid arteries was investigated. We studied 237 subjects at 50 years of age with Doppler echocardiography and ultrasound examination of the common carotid arteries. The following Doppler indices of left ventricular filling were studied: peak early diastolic velocity E-wave, peak atrial diastolic velocity A-wave and early to atrial peak velocity ratio, E/A. Carotid arterial characteristics were: distensibility coefficient, carotid arterial diameter change in systole and fractional change in the carotid arterial diameter. The relation between Doppler indices of left ventricular filling and carotid arterial characteristics was assessed by univariate and multivariate regression analysis. There was a significant univariate, positive association between E/A ratio and carotid arterial distensibility (r = 0.27, P < 0.001), carotid arterial systolic diameter change (r = 0.19, P < 0.005) and fractional change of the carotid arterial diameter (r = 0.20, P < 0.005). In multivariate analysis, E/A ratio was independently associated with carotid arterial distensibility (P < 0.005), after adjusting for heart rate, body mass index and gender. Decreased carotid arterial distensibility was associated with a reduction in E/A ratio, suggesting that arterial distensibility may have an effect on left ventricular diastolic filling or that changes in the arterial elastic properties are associated with corresponding structural changes in the left ventricle.
authors.affiliation: Department of Clinical Physiology, Central Hospital, Västerås, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Kangro
authors.forename: T
authors.initials: T
authors.lastname: Jonason
authors.forename: E
authors.initials: E
authors.lastname: Henriksen
authors.forename: I
authors.initials: I
authors.lastname: Ringqvist
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002339:Carotid Arteries / Q000000981:diagnostic imaging* / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012907:Smoking / Q000503:physiopathology; D013548:Sweden; D014280:Triglycerides / Q000097:blood; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D014280:Triglycerides; D002784:Cholesterol