title: [Sodium saccharin effect on the mice large intestine].
abstract: Sodium saccharin has found to be a tumoral promoter in the rat's bladder epithelium, property not demonstrated in humans. Nevertheless, at present there's no references on the possible alterations produced by sodium saccharin in the epithelium of the mice colon. In this work we describe the alterations produced by low doses of sodium saccharin in the epithelium of the mice colon. The changer produced by sodium saccharin consist in pleomorphic microvill with variations of form, length diameter and curvature and demonstrate by transmission electron microscopy.
authors.affiliation: Departmento Biomédico, Facultad de Medicina, Universidad de Tucumán.
authors.forename: G
authors.initials: G
authors.lastname: Torres de Mercau
authors.forename: N
authors.initials: N
authors.lastname: Riviera de Martínez Villa
authors.forename: H
authors.initials: H
authors.lastname: Vitalone
authors.forename: G
authors.initials: G
authors.lastname: Mercau
authors.forename: S
authors.initials: S
authors.lastname: Gamundi
authors.forename: N
authors.initials: N
authors.lastname: Martínez Riera
authors.forename: N
authors.initials: N
authors.lastname: Soria
mesh_terms: D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000473:pathology; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008871:Microvilli; D012439:Saccharin / Q000009:adverse effects*; D012964:Sodium; D013549:Sweetening Agents / Q000009:adverse effects*
chemical_list: D013549:Sweetening Agents; D012964:Sodium; D012439:Saccharin