title: Comparison of carprofen and flunixin meglumine as adjunctive therapy in bovine respiratory disease.
abstract: In an open, controlled, multi-centre clinical field trial, seven 'naturally occurring' outbreaks of acute febrile (rectal temperature > or = 39.5 degrees C) respiratory disease in housed calves were treated with a single antimicrobial agent, and either the non-steroidal anti-inflammatory drug (NSAID) carprofen (n = 95) or flunixin meglumine (n = 92) on an alternate basis. Carprofen was administered as a single subcutaneous injection at a mean dosage of 1.4 mg kg-1 (range 1.2 to 1.9 mg kg-1) body weight on the first day and flunixin meglumine by intravenous injection at a mean dosage of 2.0 mg kg-1 (range 1.2 to 2.6 mg kg-1) body weight on the first 3 consecutive days. All calves were examined clinically immediately prior to initial treatment and on three occasions up to 1 week after the end of treatment. There were no statically significant differences between NSAID groups in reduction of clinical parameters between examinations, or in overall efficacy. This trial demonstrated that a single dose of carprofen was equally effective as three daily doses of flunixin meglumine as adjunctive therapy to antimicrobial treatment in acute respiratory disease in calves.
authors.affiliation: Grampian Pharmaceuticals Limited, Research Division, Cumbria, UK.
authors.forename: T V
authors.initials: TV
authors.lastname: Balmer
authors.forename: P
authors.initials: P
authors.lastname: Williams
authors.forename: I E
authors.initials: IE
authors.lastname: Selman
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001835:Body Weight / Q000502:physiology; D002227:Carbazoles / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D003002:Clonixin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004196:Disease Outbreaks / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005334:Fever / Q000503:physiopathology / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008171:Lung Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D012119:Respiration / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; C014558:flunixin meglumine; C007005:carprofen; D003002:Clonixin