title: Characterization of myomodulin-related peptides from the pulmonate snail Helix aspersa.
abstract: Three myomodulin-related peptides--pQLSMLRLamide, PMSMLRLamide, and SLGMLRLamide--have been purified and sequenced from extracts of whole snails. The level of immunoreactive myomodulin was shown by HPLC and RIA to be widely distributed among 26 different snail tissues, with the highest levels (higher even than those in the central ganglia) occurring in certain male reproductive organs. Synthetic pQLSMLRLamide modified either the spontaneous rhythmic activity or the resting tone of several isolated muscular organs: the aorta, ventricle, upper gut, epiphallus, flagellum, and spermatheca; but the retractor muscles of the pharynx, penis, and tentacle were unaffected.
authors.affiliation: Whitney Laboratory, University of Florida, St. Augustine 32086-8623, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Greenberg
authors.forename: K E
authors.initials: KE
authors.lastname: Doble
authors.forename: W
authors.initials: W
authors.lastname: Lesser
authors.forename: T D
authors.initials: TD
authors.lastname: Lee
authors.forename: N A
authors.initials: NA
authors.lastname: Pennell
authors.forename: C G
authors.initials: CG
authors.lastname: Morgan
authors.forename: D A
authors.initials: DA
authors.lastname: Price
mesh_terms: D000818:Animals; D006372:Helix, Snails / Q000737:chemistry*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009479:Neuropeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011863:Radioimmunoassay; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014018:Tissue Distribution
chemical_list: D009479:Neuropeptides; C053302:myomodulin