title: Intraoperative radiation therapy combined with limited lymph node resection in gastric cancer: an alternative to extended dissection?
abstract: OBJECTIVE
  To describe the results of a series of 63 Western patients presenting with gastric adenocarcinoma and treated with surgery and intraoperative radiation therapy (IORT) over a 8-year period and to discuss the role of IORT when combined with limited lymph node dissection.
  
  
  METHODS
  From 1986 to 1993, 63 patients with gastric adenocarcinoma have been operated in the department of radiation oncology of the Hospices Civils de Lyon. The stage was: I in 17, II in 11, IIIA in 9, IIIB in 20, and IV in 6. The lymph node dissection was considered to be limited in 56 patients and extended in 7. The IORT dose ranged from 12 to 23 Gy (median: 15). Thirty patients also underwent a postoperative external beam irradiation with a standard dose of 44-46 Gy.
  
  
  RESULTS
  The postoperative mortality rate was 4.8%. The 5-year overall survival in the entire series was 47% and was 82, 55, 78, 20, and 0% in Stages I, II, IIIA, IIIB, and IV, respectively. Loco-regional relapse occurred in 15 of 63 patients and metastases in 15 of 63.
  
  
  CONCLUSIONS
  In Western patients treated by gastrectomy for adenocarcinoma of the stomach, IORT combined with limited lymph node dissection may provide overall survival similar to that observed after gastrectomy with extended lymph node dissection but with less postoperative mortality.
authors.affiliation: Service de Radiothérapie-Oncologie, Centre Hospitalier Lyon Sud and Université Claude Bernard, Pierre Bénite, France.
authors.forename: R
authors.initials: R
authors.lastname: Coquard
authors.forename: L
authors.initials: L
authors.lastname: Ayzac
authors.forename: F N
authors.initials: FN
authors.lastname: Gilly
authors.forename: F P
authors.initials: FP
authors.lastname: Rocher
authors.forename: P
authors.initials: P
authors.lastname: Romestaing
authors.forename: I
authors.initials: I
authors.lastname: Sentenac
authors.forename: Y
authors.initials: Y
authors.lastname: Francois
authors.forename: J
authors.initials: J
authors.lastname: Vignal
authors.forename: G
authors.initials: G
authors.lastname: Braillon
authors.forename: J P
authors.initials: JP
authors.lastname: Gerard
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012008:Recurrence; D013274:Stomach Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*