[A case of polyneuropathy with B-CLL and HTLV-I associated myelopathy (HAM)].
We report a case of polyneuropathy associated with chronic B lymphoid leukemia (B-CLL) and HAM. A 65-year-old man had an initial onset with polyneuropathy, then myelopathy appeared. High HTLV-I antibody and anti-ganglioside antibodies were observed. The biopsy examination of the sural nerve showed mainly demyelinated changes. Muscle weakness gradually improved after cyclophosphamide therapy. Anti-ganglioside antibodies were also decreased in titer. This case suggested that the production of antiganglioside antibodies and the occurrence of polyneuropathy might be caused by both factors of HTLV-I infected T cells and B cell tumors.
Akamatsu
M M
MM
Department of Neurology, Kinki University School of Medicine.
Mitsui
Y
Y
Kihara
M
M
Ohtsuka
K
K
Takahashi
M
M
D000368:Aged; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D015493:Paraparesis, Tropical Spastic / Q000150:complications*; D011115:Polyneuropathies / Q000209:etiology*