Epithelioid sarcoma producing granulocyte colony-stimulating factor.
An epithelioid sarcoma of the perineum of a 60-year-old man with widespread metastases produced leukocytosis, myeloid hyperplasia of the bone marrow, and splenomegaly. High titers of granulocyte colony-stimulating factor (G-CSF) were found in the patient's serum and primary culture medium of the tumor tissue. The tumor tissue extract contained m-RNA for G-CSF in large quantities, proving that the tumor was the source of this cytokine.
Sonobe
H
H
Department of Pathology, Kochi Medical School, Japan.
Ohtsuki
Y
Y
Ido
E
E
Furihata
M
M
Iwata
J
J
Enzan
H
H
Sugimoto
T
T
Asahi
Y
Y
Kubonishi
I
I
D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007264:Inguinal Canal; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010502:Perineum; D012509:Sarcoma / Q000737:chemistry* / Q000473:pathology* / Q000556:secondary
D016179:Granulocyte Colony-Stimulating Factor