Immunocytochemical and histological differences in the interrenal axis of feral brown trout, Salmo trutta, in metal-contaminated waters.
There are more CRH-like immunoreactive neurons in the preoptic nucleus and nucleus lateralis tuberis in the brain of feral brown trout, Salmo trutta, living in cadmium- and zinc-contaminated regions of the Eagle River than in fish from an uncontaminated control site. Histological analyses revealed that interrenal cells are more stimulated (exhibiting both hypertrophy and hyperplasia) in fish living in contaminated sites than interrenal cells of fish at the control site. These results suggest that the hypothalamo-pituitary-interrenal (HPI) axis of fish living in the metal-contaminated water shows evidence of chronic stimulation. We suggest that assessment of these parameters of the HPI axis may be useful indices of chronic environmental stress in trout.
Norris
D O
DO
Department of Environmental, Population, and Organismic Biology, University of Colorado, Boulder, Colorado 80309-0334, USA. norrisd@spot.colorado.edu
Felt
S B
SB
Woodling
J D
JD
Dores
R M
RM
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002104:Cadmium / Q000633:toxicity*; D003120:Colorado; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D005260:Female; D006965:Hyperplasia; D006984:Hypertrophy; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D007401:Interrenal Gland / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D014337:Trout / Q000033:anatomy & histology*; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015032:Zinc / Q000633:toxicity*
D014874:Water Pollutants, Chemical; D002104:Cadmium; D003346:Corticotropin-Releasing Hormone; D015032:Zinc