Glomerulomegaly and proteinuria in a patient with idiopathic pulmonary hypertension.
Glomerulomegaly is a histologic finding present in idiopathic pulmonary hypertension, congenital cyanotic heart disease, morbid obesity associated with sleep apnea syndrome, sickle cell disease, and polycythemic states. This study examines the case of a 34-yr-old woman with idiopathic pulmonary artery hypertension who presented with nephrotic-range proteinuria. Kidney biopsy revealed enlarged glomeruli with mesangial-proliferative glomerulonephritis. A review of the pertinent literature and a discussion of the proposed pathophysiologic mechanisms leading to glomerulomegaly are presented.
Faustinella
F
F
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Uzoh
C
C
Sheikh-Hamad
D
D
Truong
L D
LD
Olivero
J J
JJ
D000328:Adult; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000209:etiology*; D009765:Obesity / Q000150:complications; D011507:Proteinuria / Q000209:etiology*