Differential effects of somatostatin analogues on proliferation of murine colonic cancer cells in vitro.
The effects of somatostatin analogues octreotide (SMS 201-995), ASS-51 and ASS-52 on [3H]-thymidine incorporation into DNA of the murine colon 38 cancer cells in vitro were investigated. It was found that SMS 201-995 and ASS-51 inhibited the tritiated thymidine incorporation in a dose-dependent manner. In contrast, analogue ASS-52 in spite of a very similar structure to ASS-51, which differed from the latter only by one CH2OH group, was devoid of remarkable antiproliferative activity. These results indicate that slight modification of the molecule of somatostatin analogues may deeply influence their antiproliferative activity.
Pawlikowski
M
M
Department of Experimental Endocrinology, Institute of Endocrinology, Medical University of Lodz, Poland.
Kunert-Radek
J
J
Winczyk
K
K
D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms; D051379:Mice; D008969:Molecular Sequence Data; D015282:Octreotide / Q000737:chemistry / Q000494:pharmacology*; D013004:Somatostatin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D013936:Thymidine / Q000493:pharmacokinetics; D014316:Tritium; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D014316:Tritium; C083586:ASS 51; C083587:ASS 52; D013004:Somatostatin; D015282:Octreotide; D013936:Thymidine