title: Computerized analysis of interstitial infiltrates on chest radiographs: a new scheme based on geometric pattern features and Fourier analysis.
abstract: OBJECTIVE
  Detection of interstitial infiltrates on chest radiographs is difficult and subjective. Therefore, we developed a computerized method to provide quantitative analysis of lung texture to increase diagnostic accuracy.
  
  
  METHODS
  Two hundred chest radiographs--100 healthy and 100 abnormal with interstitial infiltrates--were digitized using a laser scanner. They were analyzed by an automated computerized scheme that uses a combination of two methods for detection of interstitial infiltrates: a lung texture analysis based on the Fourier transform and a geometric pattern feature analysis based on filtering techniques.
  
  
  RESULTS
  The overall sensitivity and specificity of the computerized scheme were 92% and 90%, respectively. The scheme achieved a sensitivity of 80% in subtle cases (n = 15) and 88% in cases with localized interstitial disease (n = 26), whereas the specificity remained unchanged. There was good correlation between the computer output and the radiologists' severity rating.
  
  
  CONCLUSIONS
  This enhanced computerized scheme exhibits high sensitivity and specificity with a large database.
authors.affiliation: Service de Radiologie, Hopital Saint-Antoine, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Monnier-Cholley
authors.forename: H
authors.initials: H
authors.lastname: MacMahon
authors.forename: S
authors.initials: S
authors.lastname: Katsuragawa
authors.forename: J
authors.initials: J
authors.lastname: Morishita
authors.forename: K
authors.initials: K
authors.lastname: Doi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005189:False Positive Reactions; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D017563:Lung Diseases, Interstitial / Q000145:classification / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D013902:Radiography, Thoracic / Q000145:classification / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity