[Immunochemical analysis of human monoclonal IGM with antibody cold agglutinin activity during Mycoplasma pneumoniae infection].
Mycoplasma pneumoniae (MP) infection is associated with the emergence of anti-I cold agglutinins of IgM isotype, rarely complicated by hemolytic anemia. The mechanism by which the autoimmune disease occurs is still considerably controversed. We describe here a case of MP infection complicated by severe autoimmune hemolytic anemia with monoclonal anti-I IgM. IgM anti-I antibodies were purified by adsorption-elution on OI+ red cells. The red blood cell antibodies were found to be tightly associated with IgG and anti-MP specificity probably as immune complexes. The significance of these results is discussed.
Ben Aïssa-Fennira
F
F
Laboratoire d'Hématologie et d'Immunopathologie, Faculté de Médecine de Tunis.
Bouguerra
A
A
Hafsia
R
R
Dellagi
D
D
Ben Ammar-el Gaaied
A
A
Dellagi
K
K
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000276:immunology*; D002648:Child; D003298:Coombs Test; D006801:Humans; D007120:Immunochemistry; D007075:Immunoglobulin M / Q000276:immunology*; D007525:Isoelectric Focusing; D008297:Male; D011019:Pneumonia, Mycoplasma / Q000150:complications* / Q000276:immunology*; D012680:Sensitivity and Specificity
D007075:Immunoglobulin M