Errors in clearance estimation after bolus injection and arterial sampling: nonexistence of a central compartment.
In conventional pharmacokinetics monotonic decreasing drug disposition curves are usually assumed after bolus injection. For arterial sampling starting about 1 min after dosing the resulting neglect of the initial concentration peak leads to a relative overestimation of clearance which may be approximated by the percentage of systemic drug extraction. This error can be avoided by administering the drug as a short-term infusion.
Weiss
M
M
Department of Pharmacology, Martin Luther University Halle-Wittenberg, Germany.
D001825:Body Fluid Compartments; D003198:Computer Simulation; D007275:Injections, Intravenous; D008954:Models, Biological; D010599:Pharmacokinetics