Superoxide generation by monocytes following infection with human cytomegalovirus.
A significant level of superoxide (O2-) generation was observed in a U937-derived subclone following infection with human cytomegalovirus (HCMV). Although there were no detectable levels of viral mRNA and/or protein expression, HCMV DNA content transiently increased immediately before O2- generation. Similarly, O2- generation was also observed in peripheral blood monocytes derived from healthy donors.
Suzuki
S
S
Section of Serology, Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Kameoka
M
M
Nakaya
T
T
Kimura
T
T
Nishi
N
N
Hirai
K
K
Ikuta
K
K
D003587:Cytomegalovirus / Q000235:genetics / Q000378:metabolism; D003586:Cytomegalovirus Infections / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000821:virology; D009000:Monocytes / Q000378:metabolism* / Q000821:virology*; D012333:RNA, Messenger / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*
D004279:DNA, Viral; D012333:RNA, Messenger; D013481:Superoxides