title: Beyond the wobble: the rule of conjugates.
abstract: A reexamination of the genetic code suggests a rule of conjugates which captures the observed quartet degeneracies without exception. Adenine is the conjugate of cytosine and uracil is the conjugate of guanine. Further analysis reveals that the rule of conjugates is a macrolevel manifestation of the molecular-level hydrogen-bonding and base-stacking interactions at the decoding site. This new perspective is of significance to evolutionary discussions of nucleic acid bases, genetic code, and interactions involving RNAs.
authors.forename: B
authors.initials: B
authors.lastname: Jayaram
mesh_terms: D000225:Adenine; D003596:Cytosine; D005815:Genetic Code; D006147:Guanine; D014176:Protein Biosynthesis; D014498:Uracil
chemical_list: D014498:Uracil; D006147:Guanine; D003596:Cytosine; D000225:Adenine