title: [A trial of the use of rulid, sumamed and makropen in the combined treatment of generalized periodontitis at a stage of exacerbation].
abstract: In vitro study of the antibacterial activity of macrolide antibiotics azitromycin (sumamed), midicamycin (macropen), roxitromycin (rulide), and erythromycin demonstrated their high activity towards clinical strains of bacteroids, fusobacteria, peptostreptococci, streptococci, and corynebacteria. These antibiotics were effective in the treatment of 62 adult patients with severe and moderate generalized periodontitis. Rulide and sumamed were the most effective, macropen and erythromycin were inferior to them.
authors.forename: V N
authors.initials: VN
authors.lastname: Tsarev
authors.forename: L A
authors.initials: LA
authors.lastname: Dmitrieva
authors.forename: N A
authors.initials: NA
authors.lastname: Filatova
authors.forename: A E
authors.initials: AE
authors.lastname: Romanov
authors.forename: N O
authors.initials: NO
authors.lastname: Chekhova
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use*; D002908:Chronic Disease; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use; D006801:Humans; D007933:Leucomycins / Q000627:therapeutic use*; D008875:Middle Aged; D009761:Nystatin / Q000627:therapeutic use; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology; D015575:Roxithromycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007933:Leucomycins; D009761:Nystatin; D015575:Roxithromycin; D004917:Erythromycin; D017963:Azithromycin; C026483:midecamycin