Acute lymphoblastic leukemia with isolated adrenocorticotropic hormone deficiency.
A 57-year-old female was admitted to our hospital because of Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). On admission, disturbance of consciousness and hyponatremia were recognized. The patient's endocrinological data showed low levels of adrenocorticotropic hormone (ACTH) (less than 5 pg/ml) and cortisol (5.9 microg/dl). Other anterior pituitary hormones were normal. Plasma ACTH and cortisol did not respond to the corticotropin releasing factor (CRF) test. A diagnosis of isolated ACTH deficiency was made. This is a rare case of isolated ACTH deficiency complicated with hematological malignancies.
Yamaguchi
H
H
Department of Internal Medicine, Nippon Medical School, Sendagi, Tokyo.
Nakamura
H
H
Mamiya
Y
Y
Yamamoto
Y
Y
Tajika
K
K
Sugihara
H
H
Gomi
S
S
Inokuchi
K
K
Hasegawa
S
S
Shibazaki
T
T
Dan
K
K
Wakabayashi
I
I
D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000150:complications / Q000188:drug therapy; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D005938:Glucocorticoids; D014750:Vincristine; D004317:Doxorubicin; D000324:Adrenocorticotropic Hormone; D011239:Prednisolone