title: The measurement of R2, R2* and R2' in HIV-infected patients using the prime sequence as a measure of brain iron deposition.
abstract: Brain iron deposition was assessed at 1.5 T in the caudate nucleus, globus pallidus and frontal and parieto-occipital white matter in 28 human immunodeficiency virus (HIV)-infected patients and 15 control subjects with a new Partially Refocussed Interleaved Multi-Echo sequence by measuring 1/T2, 1/T2* and 1/T2' (i.e., R2, R2* and R2'). There were significant differences in the R2 and R2* of the caudate nucleus (p < 0.0001 and p < 0.05) and the R2, R2* and R2' of the globus pallidus (p < 0.01, p < 0.005 and p < 0.05) in HIV-infected patients compared to control subjects. There was a trend for higher values of R2, R2* and R2' in the globus pallidus and caudate nucleus in HIV-infected patients with later stage HIV disease. These results suggest that there is greater iron deposition in the basal ganglia of HIV-infected patients compared with control subjects, with a predilection for the globus pallidus. The relationship between iron deposition in the brain and various parameters of severity of HIV infection remains uncertain.
authors.affiliation: Department of Radiology at UCL Hospitals (NHS) Trust, London, UK. kathm@medphys.ucl.ac.uk
authors.forename: K A
authors.initials: KA
authors.lastname: Miszkiel
authors.forename: M N
authors.initials: MN
authors.lastname: Paley
authors.forename: I D
authors.initials: ID
authors.lastname: Wilkinson
authors.forename: M A
authors.initials: MA
authors.lastname: Hall-Craggs
authors.forename: R
authors.initials: R
authors.lastname: Ordidge
authors.forename: B E
authors.initials: BE
authors.lastname: Kendall
authors.forename: R F
authors.initials: RF
authors.lastname: Miller
authors.forename: M J
authors.initials: MJ
authors.lastname: Harrison
mesh_terms: D015526:AIDS Dementia Complex / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D001479:Basal Ganglia / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D018791:CD4 Lymphocyte Count; D002421:Caudate Nucleus / Q000378:metabolism / Q000473:pathology; D005260:Female; D005917:Globus Pallidus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D007501:Iron