title: Effects of low doses of prostaglandin F2 alpha during the early luteal phase before and after implantation in beagle bitches.
abstract: Three groups of five beagle bitches were treated three times a day with natural prostaglandin F2 alpha (PGF2 alpha) at a dosage of either 20 micrograms kg-1 bodyweight (days 5-8 of metoestrus), 50 micrograms kg-1 bodyweight (days 5-11 of metoestrus) or 20 micrograms kg-1 bodyweight after detection of pregnancy (days 20-21 after ovulation) for 7 days. A dose of 20 micrograms PGF2 alpha kg-1 bodyweight administered during the early luteal stage could not induce a reliable decrease of progesterone concentrations, while injections of 50 micrograms PGF2 alpha kg-1 bodyweight beginning before implantation resulted in arrest of luteal progesterone production and prevention of nidation in all five bitches. The application of 20 micrograms PGF2 alpha kg-1 bodyweight shortly after implantation induced functional arrest of corpora lutea and led to embryonic or fetal resorption in all cases. In general, the luteolytic effect of low PGF2 alpha doses was insufficient because of the recovery of the corpora lutea seen in nearly all bitches and the prolonged process of embryonic or fetal resorption that increase the risk of uterine disease.
authors.affiliation: Department of Reproductive Medicine, School of Veterinary Medicine, Hannover, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Lange
authors.forename: A R
authors.initials: AR
authors.lastname: Günzel-Apel
authors.forename: H O
authors.initials: HO
authors.lastname: Hoppen
authors.forename: R
authors.initials: R
authors.lastname: Mischke
authors.forename: I
authors.initials: I
authors.lastname: Nolte
mesh_terms: D000028:Abortion, Induced / Q000662:veterinary*; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D015237:Dinoprost / Q000008:administration & dosage*; D004285:Dogs / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule / Q000662:veterinary; D010064:Embryo Implantation / Q000187:drug effects; D020964:Embryo Loss / Q000662:veterinary; D047108:Embryonic Development; D005260:Female; D005327:Fetal Resorption / Q000662:veterinary; D007279:Injections, Subcutaneous; D011247:Pregnancy; D011374:Progesterone / Q000097:blood
chemical_list: D011374:Progesterone; D015237:Dinoprost