Cultured allogeneic keratinocyte sheets accelerate healing compared to Op-site treatment of donor sites in burns.
Donor site treatment is a crucial issue in the treatment of extensive burns. In this single-blind, randomized study treatment of donor sites with a polyurethane dressing, Op-Site (Smith & Nephew, York, U.K.) is compared to treatment with allogeneic cultured keratinocyte sheets. Results show a mean healing time of 6.7 days with use of cultured keratinocyte sheets compared to mean healing time of 13.6 days with Op-Site treatment. Also, improvement in the comfort of patients as the result of less exudate formation and pain attenuation was noted.
Duinslaeger
L A
LA
Burn Center Brussels and Military Hospital, Belgium.
Verbeken
G
G
Vanhalle
S
S
Vanderkelen
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009779:Occlusive Dressings; D010146:Pain / Q000517:prevention & control; D011140:Polyurethanes / Q000627:therapeutic use*; D011446:Prospective Studies; D016038:Skin Transplantation / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014945:Wound Healing
D011140:Polyurethanes