Effects of calcium on left ventricular function early after cardiopulmonary bypass.
OBJECTIVE
Evaluation of the effects of intravenous CaCl2 on systolic and diastolic function early after separation from cardiopulmonary bypass (CPB) DESIGN: Prospective study


METHODS
University hospital


METHODS
Twenty patients scheduled for elective coronary artery surgery


METHODS
Left ventricular (LV) pressures were measured with fluid-filled catheters. Data were digitally recorded during pressure elevation induced by tilt-up of the legs. Transgastric short-axis echocardiographic views of the LV were simultaneously recorded on videotape. Measurements were obtained before the start of CPB, 10 minutes after termination of CPB, after intravenous administration of CaCl2, 5 mg/kg, and 10 minutes later.


RESULTS
Systolic function was evaluated with the slope (Ees, mmHg/mL) of the systolic pressure-volume relation. Diastolic function was evaluated with the chamber stiffness constant (Kc, mmHg/mL) of the diastolic pressure-volume relation. CaCl2 increased Ees from 2.62 +/- 0.46 to 5.58 +/- 0.61 (mean +/- SD), but induced diastolic dysfunction with an increase in Kc from 0.011 +/- 0.006 to 0.019 +/- 0.007. These changes were transient and had disappeared within 10 minutes after administration of CaCl2.


CONCLUSIONS
CaCl2 early after CPB transiently improved systolic function at the expense of an increase in ventricular stiffness, suggesting temporary diastolic dysfunction.
DeHert
S G
SG
Department of Anesthesiology, University Hospital Antwerp, University of Antwerp, Belgium.
Ten Broecke
P W
PW
De Mulder
P A
PA
Rodrigus
I E
IE
Haenen
L R
LR
Boeckxstaens
C J
CJ
Vermeyen
K M
KM
Gillebert
T C
TC
Moulijn
A C
AC
D000328:Adult; D000368:Aged; D002118:Calcium / Q000494:pharmacology*; D002315:Cardiopulmonary Bypass; D003971:Diastole / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013318:Stroke Volume / Q000187:drug effects; D013599:Systole / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects*
D002118:Calcium