title: Medial border of the perirenal space: CT and anatomic correlation.
abstract: OBJECTIVE
  To explore the mode of spread of disease between the perirenal space and the perivascular central retroperitoneum and to determine the anatomy along the medial border of the perirenal space.
  
  
  METHODS
  Anatomic dissection, injection of latex, and observation of cross sections of the abdomen were performed in nine cadavers. Attention was paid to the juncture of the central prevertebral, perivascular, and extraperitoneal regions, and the perirenal space. Anatomic findings were correlated with observations made at computed tomography (CT) in 82 patients with retroperitoneal hemorrhage (n = 24), inflammation (n = 37), and neoplasia (n = 21) involving the perirenal spaces or the central retroperitoneum.
  
  
  RESULTS
  Along most of the length of each kidney, no apparent fascia separates the perirenal space from the central retroperitoneum. At this location, septa between fat lobules form a fenestrated multitier barrier. These septa were imperceptible on CT scans obtained in healthy individuals. After injection of latex in cadavers, this potential barrier was seen. In the clinical study, spread of disease was allowed in only 38 (30%) of 128 instances of potential spread. Spread was facilitated along the renal vessels and the interlobular septa.
  
  
  CONCLUSIONS
  Beyond the kidneys, the renal fascia is closed, forming a cone superiorly and an inverted cone inferiorly. A network of interlobular septa acted as a barrier or pathway to the free spread of disease from the perirenal space to the central retroperitoneum or from the central retroperitoneum to the perirenal space.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
authors.forename: V
authors.initials: V
authors.lastname: Raptopoulos
authors.forename: P
authors.initials: P
authors.lastname: Touliopoulos
authors.forename: Q F
authors.initials: QF
authors.lastname: Lei
authors.forename: T G
authors.initials: TG
authors.lastname: Vrachliotis
authors.forename: S C
authors.initials: SC
authors.lastname: Marks
mesh_terms: D000328:Adult; D002102:Cadaver; D006470:Hemorrhage / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012186:Retroperitoneal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012187:Retroperitoneal Space / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed