title: Searching for migraine genes: exclusion of 290 cM out of the whole human genome.
abstract: A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (1p36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the chi 2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.
authors.affiliation: Laboratorio di Neurogenetica, Università di Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Monari
authors.forename: M
authors.initials: M
authors.lastname: Mochi
authors.forename: M L
authors.initials: ML
authors.lastname: Valentino
authors.forename: C
authors.initials: C
authors.lastname: Arnaldi
authors.forename: P
authors.initials: P
authors.lastname: Cortelli
authors.forename: A
authors.initials: A
authors.lastname: De Monte
authors.forename: G
authors.initials: G
authors.lastname: Pierangeli
authors.forename: G
authors.initials: G
authors.lastname: Prologo
authors.forename: C
authors.initials: C
authors.lastname: Scapoli
authors.forename: S
authors.initials: S
authors.lastname: Soriani
authors.forename: P
authors.initials: P
authors.lastname: Montagna
mesh_terms: D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis / Q000235:genetics; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D011985:Receptors, Serotonin / Q000235:genetics
chemical_list: D011985:Receptors, Serotonin; D004247:DNA