[The dual role of tumor necrosis factor (TNF) during a malarial attack].
The roles of the various factors implicated in the pathogenesis of severe malaria are not well understood. Tumor necrosis factor (TNF), a cytokine produced mainly by macrophages, seems to play a crucial role in both the host's defence against the parasite and the development of severe complications. This review investigates the dual role of TNF in acute malaria, summarizing current knowledge of the beneficial and detrimental effects of this molecule. Recent work has suggested a possible explanation for this dualism, involving a complex interaction between TNF and its soluble receptors.
Brandts
C H
CH
Laboratoire de recherches, Hôpital Albert-Schweitzer, Lambaréné, Gabon.
Mordmüller
B G
BG
Lehman
L G
LG
Kremsner
P G
PG
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D006801:Humans; D008264:Macrophages / Q000502:physiology; D008288:Malaria / Q000503:physiopathology* / Q000517:prevention & control; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects / Q000502:physiology* / Q000627:therapeutic use
D000962:Antimalarials; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha