title: The correlation between prostate-specific antigen and age. Analysis of prostate-specific antigen values from 4,846 Turkish men with symptomatic benign prostatic hyperplasia.
abstract: OBJECTIVE
  To analyze serum prostate-specific antigen (PSA) levels of men proven to have benign prostatic hyperplasia (BPH) and to document any correlation between PSA, age and resected or enucleated prostate tissue.
  
  
  METHODS
  Serum PSA values, age and weight of specimens of 4,846 men who underwent prostatectomy in the Ankara region between January 1, 1991, and December 24, 1995, were reviewed retrospectively.
  
  
  RESULTS
  Serum PSA values correlated directly with age (Pearson's r = 0.45, p < 0.00001). The mean PSA values of men in each decade of age differed significantly (p < 0.0001) from all other decades. However, the correlation between the weight of the prostatectomy specimen and age or PSA did not reach statistical significance.
  
  
  CONCLUSIONS
  The effect of age on PSA is evident in men with symptoms of BPH. The existence of symptomatic BPH should also be considered together with age when interpreting PSA levels.
authors.affiliation: Urology Clinic of the Ministry of Health, Ankara Hospital, Turkey.
authors.forename: M C
authors.initials: MC
authors.lastname: Uygur
authors.forename: D
authors.initials: D
authors.lastname: Erol
authors.forename: M
authors.initials: M
authors.lastname: Cetinkaya
authors.forename: Y
authors.initials: Y
authors.lastname: Güngen
authors.forename: Y
authors.initials: Y
authors.lastname: Laleli
authors.forename: U
authors.initials: U
authors.lastname: Altuğ
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000000981:diagnostic imaging; D012016:Reference Values; D012189:Retrospective Studies; D014421:Turkey; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen