A CTD function linking transcription to splicing.
Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.
Corden
J L
JL
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jeff_corden@qmail.bs.jhu.edu
Patturajan
M
M
D000818:Animals; D006801:Humans; D012319:RNA Polymerase II / Q000737:chemistry / Q000235:genetics*; D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing; D014158:Transcription, Genetic
D012322:RNA Precursors; D012319:RNA Polymerase II