[Influence of difuracil (PAP-49) on normal intestinal microflora of rabbits. In vitro and in vivo experiments].
The influence of difuracil (PAP-49), a novel nitrofuran, on saprotrophic and normal digestive tract microflora was studied in vitro and in vivo by comparison with that of furazolidone. It was shown that the minimum inhibitory concentration of both the drugs ranged from 0.01 to 1.56 micrograms/ml. The experiments on rabbits with the use of the drugs in doses of 5 and 10 mg/ kg body weight revealed that unlike furazolidone difuracil induced no noticable qualitative or quantitative changes in the intestinal microflora composition.
Terekhov
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D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000633:toxicity*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005664:Furazolidone / Q000633:toxicity; D007422:Intestines / Q000187:drug effects* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D009581:Nitrofurans / Q000008:administration & dosage / Q000633:toxicity; D011817:Rabbits
D000900:Anti-Bacterial Agents; D003470:Culture Media; D009581:Nitrofurans; C095288:difuracil; D005664:Furazolidone