Analysis of a cDNA sequence encoding a novel member of the snake venom metalloproteinase, disintegrin-like, cysteine-rich (MDC) protein family from Agkistrodon contortrix laticinctus.
In this paper, we present a cDNA sequence encoding a full-length precursor form of a new member (ACLD) of the metalloproteinase-disintegrin-like protein family from the venom glands of Agkistrodon contortrix laticinctus (broad-banded copperhead) snake. Comparison of the deduced amino acid sequence of ACLD with those of other members of the metalloproteinase-disintegrin protein family from both mammalian and snake venom origin suggests that some conserved residues may be involved in processing of the disintegrin domain.
Selistre de Araujo
H S
HS
Departamento de Ciências Fisiológicas, Universidade Federal de Sao Carlos, SP, Brazil. hsaraujo@power.ufscar.br
de Souza
D H
DH
Ownby
C L
CL
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D003435:Crotalid Venoms / Q000737:chemistry* / Q000235:genetics; D003545:Cysteine / Q000737:chemistry* / Q000235:genetics; D018076:DNA, Complementary / Q000032:analysis* / Q000302:isolation & purification; D019483:Disintegrins / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D011498:Protein Precursors / Q000737:chemistry / Q000235:genetics; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid
C031442:Agkistrodon venoms; D003435:Crotalid Venoms; D018076:DNA, Complementary; D019483:Disintegrins; D011498:Protein Precursors; D008666:Metalloendopeptidases; D003545:Cysteine