title: Optimisation of the enantiomeric separation of 12 2-aminotetralin analogues using Chiral AGP high-performance liquid chromatography by simultaneous factorial design.
abstract: A method for the simultaneous optimisation of mobile phase composition for the resolution of pairs of enantiomers of 12 2-aminotetralin analogues is presented. The selectivity necessary to discriminate between 12 analytes was obtained by using mass selective detection. The ability to examine more than a few analytes at a time extends the otherwise limited applicability of a factorial design strategy to the rapid development of chiral assays.
authors.affiliation: Pharmacia and Upjohn, Crawley, West Sussex, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Wood
authors.forename: J M
authors.initials: JM
authors.lastname: Long
authors.forename: R J
authors.initials: RJ
authors.lastname: Simmonds
authors.forename: J W
authors.initials: JW
authors.lastname: Bridges
authors.forename: D
authors.initials: D
authors.lastname: Stevenson
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D013764:Tetrahydronaphthalenes / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D013764:Tetrahydronaphthalenes; C006561:2-aminotetralin