Aortic dissection in a patient receiving chemotherapy for Hodgkin's disease--a case report.
Cancer chemotherapy is associated with a wide range of vascular toxicities, which may be related to endothelial cell damage by these agents. The authors describe a patient with Hodgkin's disease who developed an atypical aortic dissection while receiving MOPP/ABV chemotherapy (nitrogen mustard, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine). They would place aortic dissection on the list of potential vascular complications associated with antineoplastic agents.
Golden
M A
MA
Department of Surgery, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Vaughn
D J
DJ
Crooks
G W
GW
Holland
G A
GA
Bavaria
J E
JE
D000328:Adult; D000784:Aortic Dissection / Q000139:chemically induced* / Q000175:diagnosis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001011:Aorta / Q000473:pathology; D001014:Aortic Aneurysm / Q000139:chemically induced* / Q000175:diagnosis; D001027:Aortography; D001761:Bleomycin / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects; D011241:Prednisone / Q000009:adverse effects; D011344:Procarbazine / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000009:adverse effects; D014750:Vincristine / Q000009:adverse effects
D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014747:Vinblastine; D004317:Doxorubicin; D011241:Prednisone