Synthesis and properties of some aminoalkanolic derivatives of xanthone.
A series of appropriate aminoalkanolic derivatives of xanthone III-VIII was synthesized and evaluated as potential antiarrhythmic agents. They were also tested for the effect on the cardiovascular system. The structure of the synthesized compounds was verified by IR 1H NMR, 13C NMR and mass spectral data.
Marona
H
H
Department of Chemical Technology of Drugs, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Szneler
E
E
Filipek
B
B
Sapa
J
J
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D004837:Epinephrine; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D044004:Xanthones
D000889:Anti-Arrhythmia Agents; D014966:Xanthenes; D044004:Xanthones; C009689:xanthone; D004837:Epinephrine