CGP 42112A abolishes facilitation of recognition caused by angiotensin II and angiotensin II(3-7) in rats.
The role of the angiotensin AT2 receptors in some behavioural effects of angiotensin II (Ang II) and its 3-7 fragment [Ang II(3-7)], using their selective antagonist CGP 42112A, was assessed. Ang II and Ang II(3-7), given intracerebroventricularly (icv) at the dose of 1 nmole each, substantially improved object recognition memory and enhanced apomorphine (1 mg/kg) stereotypy. Pre-treatment of rats with CGP 42112A (2 micrograms), per se ineffective in all tests, abolished activity of both peptides. None of the treatments significantly changed behaviour of rats in open field. The results point to the considerable involvement of the AT2 angiotensin receptors in the improvement of recognition memory caused by Ang II and Ang II(3-7).
Braszko
J J
JJ
Department of Pharmacology, Medical Academy of Białystok, Poland.
Kułakowska
A
A
Winnicka
M M
MM
Karwowska-Polecka
W
W
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology*; D010364:Pattern Recognition, Visual / Q000187:drug effects* / Q000502:physiology*; D010446:Peptide Fragments / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D009842:Oligopeptides; D010446:Peptide Fragments; D000804:Angiotensin II; C069545:angiotensin II (3-7); C060894:CGP 42112A