Assessment of regional cortical blood flow following traumatic lesion of the brain.
A brain tissue necrosis from trauma gradually expands during the subsequent 24 h. Among others, deterioration of perifocal blood flow could be involved in the secondary extinction of initially viable brain tissue. A highly standardized freezing lesion was made in cerebral cortex of rats for frequent measurements of regional cortical blood flow with high spatial resolution by laser Doppler scanning flowmetry. Following trauma a profound decrease in cerebral blood flow was found, not only in the lesion proper but also in the perifocal and distant brain areas, which would support a role of ischemia in the secondary lesion growth. Further studies, however, are required, particularly on whether therapeutic improvement of perifocal flow is affecting expansion of the traumatic tissue necrosis.
Eriskat
J
J
Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Federal Republic of Germany.
Plesnila
N
N
Stoffel
M
M
Baethmann
A
A
D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005069:Evaluation Studies as Topic; D017078:Laser-Doppler Flowmetry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley