Induction of matrix metalloproteinases following brain injury in rats.
Matrix metalloproteinases (MMPs) are important in various pathophysiological processes related with the tissue remodeling. We planned the experiments to determine whether MMPs participate in disruption and repair of the tissue following brain injury. We have studied induction of MMP-9, a 92 kilodalton (kDa) gelatinase, in traumatic brain tissue, which may be produced by brain residual cells. We speculate that MMP-9 plays a role in post-traumatic brain edema formation.
Shibayama
M
M
Department of Neurosurgery, Nagoya University School of Medicine, Japan.
Kuchiwaki
H
H
Inao
S
S
Ichimi
K
K
Yoshida
J
J
Hamaguchi
M
M
D000818:Animals; D001930:Brain Injuries / Q000201:enzymology*; D017364:Collagenases / Q000096:biosynthesis*; D004591:Electrophoresis, Polyacrylamide Gel; D004790:Enzyme Induction; D008297:Male; D020780:Matrix Metalloproteinase 9; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats
D017364:Collagenases; D020780:Matrix Metalloproteinase 9