Anti-epiligrin (laminin 5) cicatricial pemphigoid and lung carcinoma: coincidence or association?
Anti-epiligrin cicatricial pemphigoid (CP) is a rare subset of CP in which patients have IgG autoantibodies directed against the dermal side of skin split by 1 mol/L NaCl. The antibodies react against epitopes in the lowermost portions of the lamina lucida, and immunoprecipitate epiligrin (laminin 5) in human keratinocyte extracts. We report a patient with this uncommon form of CP, who, following an 8-year period of well-controlled disease, experienced a severe flare in symptoms coincident with development of lung carcinoma. This raises the possibility of an association, in this case, between anti-epiligrin CP and lung carcinoma.
Gibson
G E
GE
Department of Dermatology, Mayo Clinic, Rochester, MN 55901, USA.
Daoud
M S
MS
Pittelkow
M R
MR
D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D018287:Carcinoma, Large Cell / Q000150:complications* / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology*; D003229:Conjunctival Diseases / Q000209:etiology* / Q000276:immunology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010390:Pemphigoid, Benign Mucous Membrane / Q000150:complications* / Q000276:immunology; D000097794:Kalinin
D001323:Autoantibodies; D015815:Cell Adhesion Molecules; D000097794:Kalinin