P2-reactive T cells in inflammatory demyelination of the peripheral nerve.
Lewis rats immunized with P2 protein, a 14.5-kDa protein of the peripheral nerve myelin, develop experimental allergic neuritis, a paralytic disorder with clinical, histologic, and electrophysiologic features similar to those of human Guillain-Barré syndrome (GBS). T cells reactive to P2 protein or a peptide corresponding to 53-78 residues of the protein can transfer the disease to naive animals. The mechanisms by which these T cells induce demyelination are not well understood; however, they may induce inflammation and demyelination in the nerves by production of Th1 cytokines. Th2 cytokines may lead to suppression of the inflammation and eventual recovery. There is no conclusive evidence that P2 protein plays a role in the pathogenesis of GBS, with or without association with Campylobacter jejuni; however, studies of the immunopathogenesis of P2 protein-induced experimental allergic neuritis are important for understanding the pathogenesis of inflammatory demyelination in the peripheral nerves, the hallmark of GBS.
Rostami
A M
AM
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
D019264:Adoptive Transfer; D000818:Animals; D002169:Campylobacter Infections / Q000276:immunology; D016123:Campylobacter jejuni / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003711:Demyelinating Diseases; D004195:Disease Models, Animal; D006801:Humans; D018996:Myelin P2 Protein / Q000276:immunology*; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000276:immunology* / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines; D018996:Myelin P2 Protein