title: Quantitative study of ductal breast cancer--patient targeted prognosis: an exploration of case base reasoning.
abstract: Current analytic methodologies allow the extraction, even from small tumor masses, of extensive information on the biologic characteristics of malignant lesions, such as tumor aggressivity, metastatic potential, drug resistance, and host interactions. Clinical practice now offers a wide range of therapeutic strategies. Information technological advances offer the opportunity to refer to very large data bases of patient anamnestic data, response to treatment and clinical outcome. There is a need to formulate therapy and prognosis for each individual case. Case based reasoning is a knowledge based methodology where the outcome for complex situations can be predicted by referring to a large data base of cases of known outcomes. The preliminary data obtained from this study suggest that case based reasoning may offer a promising approach to individual targeted prognosis.
authors.affiliation: Istituto di Anatomia Patologica, Università di Verona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Mariuzzi
authors.forename: A
authors.initials: A
authors.lastname: Mombello
authors.forename: L
authors.initials: L
authors.lastname: Mariuzzi
authors.forename: P W
authors.initials: PW
authors.lastname: Hamilton
authors.forename: J E
authors.initials: JE
authors.lastname: Weber
authors.forename: D
authors.initials: D
authors.lastname: Thompson
authors.forename: P H
authors.initials: PH
authors.lastname: Bartels
mesh_terms: D001943:Breast Neoplasms / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology; D018270:Carcinoma, Ductal, Breast / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology; D019090:Case Management; D002466:Cell Nucleolus / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D003627:Data Interpretation, Statistical; D003657:Decision Making; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016247:Information Storage and Retrieval; D007558:Italy / Q000453:epidemiology; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D016896:Treatment Outcome
chemical_list: D018809:Proliferating Cell Nuclear Antigen