title: [A case of chronic necrotizing pulmonary aspergillosis successfully treated with combination therapy of antifungal drugs and ulinastatin].
abstract: A 64-year-old woman with a history of old tuberculosis, had a fungus ball shadow with meniscus sign in the upper right lung field on a chest X-ray film in 1991. Based on the chest X-ray findings, pulmonary aspergilloma was suspected. Because the size of the intracavitary fungus ball increased, the patient was treated with itraconazole over one year in 1995, but there was no improvement. One month later, she was admitted because of fever, hemoptysis and productive cough, and chest X-ray showed an enlargement of intracavitary mass and infiltrative shadow in the right lung. Chronic necrotizing aspergillosis was diagnosed on the basis of her clinical and radiographic features, and positive serological test. Although itraconazol and amphotericin B were given, cavity and intracavitary fungus ball shadow kept growing. Combination therapy of antifungal drugs and ulinastatin markedly improved symptoms and resulted in complete disappearance of the fungus ball on chest CT scan.
authors.affiliation: Department of Pulmonary Medicine, Seirei Hamamatsu Hospital, Shizuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Taira
authors.forename: H
authors.initials: H
authors.lastname: Katsura
authors.forename: C
authors.initials: C
authors.lastname: Kadoriku
authors.forename: I
authors.initials: I
authors.lastname: Hashimoto
authors.forename: N
authors.initials: N
authors.lastname: Sakai
authors.forename: A
authors.initials: A
authors.lastname: Chiyotani
authors.forename: I
authors.initials: I
authors.lastname: Yamawaki
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy* / Q000473:pathology; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D005260:Female; D006023:Glycoproteins / Q000008:administration & dosage*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009336:Necrosis; D014361:Trypsin Inhibitors / Q000008:administration & dosage*
chemical_list: D000935:Antifungal Agents; D006023:Glycoproteins; D014361:Trypsin Inhibitors; D000666:Amphotericin B; C028665:urinastatin