Sesquiterpenoids of the drimane class from a sponge of the genus Dysidea.
Ten sesquiterpenoids, including seven new ones, have been isolated from an undescribed sponge of the genus Dysidea. Compounds 1-8 are sesquiterpenoids of the drimane class, while 9 and 10 are 12-norsesquiterpenoids of the same structural class. The structures of novel compounds have been determined by combined spectroscopic methods. These compounds exhibited moderate antimicrobial and enzyme inhibitory (Na+/K(+)-ATPase and PLA2) activities.
Paul
V J
VJ
Marine Laboratory, University of Guam, Korea.
Seo
Y
Y
Cho
K W
KW
Rho
J R
JR
Shin
J
J
Bergquist
P R
PR
D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013056:Spectrophotometry, Ultraviolet
D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D012717:Sesquiterpenes; D010741:Phospholipases A; D054467:Phospholipases A2; D000254:Sodium-Potassium-Exchanging ATPase