New DNA minor-groove binding molecules with high sequence-selectivities and binding affinities.
New DNA minor-groove binding molecules with high binding affinities and sequence-selectivities are described. The effects of structural changes in ligands with a three-ring backbone on their DNA-binding properties have been studied. Of a pool of eight potential ligands, two showed binding affinities and sequence-selectivities rivaling distamycin. The two best ligands share a common structural motif that involves a para-di-substituted benzene ring flanked by two meta-di-substituted benzene rings.
Gong
B
B
Department of Chemistry, University of Toledo, Ohio 43606, USA. bgong@uoft03.utoledo.edu
Yan
Y
Y
D000818:Animals; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism; D004996:Ethidium / Q000378:metabolism; D006860:Hydrogen Bonding; D008024:Ligands; D015394:Molecular Structure; D010671:Phenylurea Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D010795:Phthalic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D011089:Polydeoxyribonucleotides / Q000378:metabolism; D013950:Thymus Gland / Q000737:chemistry
D001549:Benzamides; D001555:Benzene Derivatives; D004279:DNA, Viral; D008024:Ligands; D010671:Phenylurea Compounds; D010795:Phthalic Acids; D011089:Polydeoxyribonucleotides; C019530:poly(dC-dG); C084838:polydeoxyadenylic acid-polythymidylic acid; D004247:DNA; D004996:Ethidium