[The influence of thrombopoietin (TpO) on human erythropoiesis. In vitro studies--clinical implications].
The role of thrombopoietin (TpO) in regulations erythropoiesis is still controversial. This fact prompt us to present our own data. We found, that TpO is not able to replace erythropoietin (EpO) in stimulation of the growth of human erythroid colonies. TpO was found to be only a very weak costimulator of EpO dependent erythroid progenitors growth. This effect is however much weaker than those observed after costimulation with kit ligand or interleukin-3. The rationale for TpO application for treatment of anemia in humans seems therefore doubtful. This conclusion seems now to be supported by the results of the first trials performed in anemic patients.
Machaliński
B
B
Zakładu Patologii Komórki PAM w Szczecinie.
Marlicz
W
W
Płuciennik
E
E
Ratajczak
J
J
Ratajczak
M Z
MZ
D018952:Antigens, CD34 / Q000032:analysis; D002478:Cells, Cultured; D004912:Erythrocytes / Q000502:physiology; D004920:Erythropoiesis / Q000502:physiology*; D006021:Glycophorins / Q000032:analysis; D006801:Humans; D012016:Reference Values; D013234:Stem Cells; D013926:Thrombopoietin / Q000502:physiology*
D018952:Antigens, CD34; D006021:Glycophorins; D013926:Thrombopoietin