title: IMGT, the International ImMunoGeneTics database.
abstract: IMGT, the international ImMunoGeneTics database, is an integrated database specialising in Immunoglobulins (Ig), T cell Receptors (TcR) and Major Histocompatibility Complex (MHC) of all vertebrate species, created by Marie-Paule Lefranc, CNRS, Montpellier II University, Montpellier, France (lefranc@ligm.crbm.cnrs-mop.fr). IMGT includes three databases: LIGM-DB (for Ig and TcR), MHC/HLA-DB and PRIMER-DB (the last two in development). IMGT comprises expertly annotated sequences and alignment tables. LIGM-DB contains more than 23 000 Immunoglobulin and T cell Receptor sequences from 78 species. MHC/HLA-DB contains Class I and Class II Human Leucocyte Antigen alignment tables. An IMGT tool, DNAPLOT, developed for Ig, TcR and MHC sequence alignments, is also available. IMGT works in close collaboration with the EMBL database. IMGT goals are to establish a common data access to all immunogenetics data, including nucleotide and protein sequences, oligonucleotide primers, gene maps and other genetic data of Ig, TcR and MHC molecules, and to provide a graphical user friendly data access. IMGT has important implications in medical research (repertoire in autoimmune diseases, AIDS, leukemias, lymphomas), therapeutical approaches (antibody engineering), genome diversity and genome evolution studies. IMGT is freely available at http://imgt.cnusc.fr:8104
authors.affiliation: Laboratoire d'ImmunoGénétique Moléculaire, LIGM, UMR 5535 (CNRS, Université Montpellier II), 1919 route de Mende, 34293 Montpellier Cedex 5, France. lefranc.ligm.crbm.cnrs-mop.fr
authors.forename: M P
authors.initials: MP
authors.lastname: Lefranc
authors.forename: V
authors.initials: V
authors.lastname: Giudicelli
authors.forename: C
authors.initials: C
authors.lastname: Busin
authors.forename: J
authors.initials: J
authors.lastname: Bodmer
authors.forename: W
authors.initials: W
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Bontrop
authors.forename: M
authors.initials: M
authors.lastname: Lemaitre
authors.forename: A
authors.initials: A
authors.lastname: Malik
authors.forename: D
authors.initials: D
authors.lastname: Chaume
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003195:Computer Communication Networks; D016208:Databases, Factual; D006801:Humans; D007125:Immunogenetics; D008969:Molecular Sequence Data; D016415:Sequence Alignment