title: A new concept of immune specificity emerges from a consideration of the self-nonself discrimination.
abstract: The necessity to make a Self(S)-NonSelf(NS) discrimination is the evolutionary selection pressure for specificity of the immune response. A new definition of paratopic specificity, which is heuristic and generalizable, can be derived from an understanding of this selection pressure. Specificity of the paratope is defined by a Specificity Constant, K, which is the probability that a functional change in recognition will be anti-Self. In an antigen-unselected population, K is the proportion of cells that are anti-Self. This definition is unique in that it is derived from the function upon which evolution selects, namely the effector output. This paper describes how the concept of a Specificity Constant was derived, how it is estimated, what it can be used to explain, and how it impacts on repertoire and effectiveness of response.
authors.affiliation: Conceptual Immunology Group, Salk Institute for Biological Studies, San Diego, California 92186-5800, USA.
authors.forename: M
authors.initials: M
authors.lastname: Cohn
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D006801:Humans; D018448:Models, Immunological; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D017634:Self Tolerance
chemical_list: D000906:Antibodies; D000941:Antigens; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell