Effects of an acute exposure to lindane (gamma-hexachlorocyclohexane) on brain and liver carbohydrate metabolism of rainbow trout.
The capacity of carbohydrate and ketone bodies metabolism in brain and liver was evaluated in rainbow trout control and exposed to lindane (0.05 mg.L-1) for 12 hr. The results obtained demonstrate the existence of changes in several parameters of brain carbohydrate metabolism due to lindane treatment. Thus, increased plasma glucose levels are reflected in brain by the mobilization of glycogen stores and increased lactate levels probably reflecting an increased anaerobic use. Also, ketone bodies appear to be used under this stressful condition. In liver, the main results obtained suggest that glycogen stores are being mobilized to be probably used as glucose in pathways other than glycolysis.
Soengas
J L
JL
Facultade de Ciencias, Universidade de Vigo, Vigo, 36200, Spain.
Strong
E F
EF
Aldegunde
M
M
Andrés
M D
MD
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D050260:Carbohydrate Metabolism; D006003:Glycogen / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D007657:Ketone Bodies / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D017683:Oncorhynchus
D001786:Blood Glucose; D007306:Insecticides; D007657:Ketone Bodies; D001556:Hexachlorocyclohexane; D006003:Glycogen