title: Effect of respiratory rate on respiratory patterns in patients with chronic obstructive pulmonary disease.
abstract: We enrolled 22 patients with chronic obstructive pulmonary disease (COPD) and 20 normal subjects as controls. Using a hot-wire flow meter, we obtained tidal volume (VT), duty ratio (Ti/Ttot), and mean inspiratory flow (VT/Ti) as measures of respiratory pattern at two different respiratory rates; 0.5 Hz and 1.5 Hz. At 0.5 Hz, there were significant differences in Ti/Ttot and VT/Ti. At 1.5 Hz, patients with COPD had significantly lower values of VT and VT/Ti. Furthermore, we calculated the change ratios from 0.5 Hz to 1.5 Hz in these parameters as new parameters of respiratory pattern change by respiratory rate. VT0.5/1.5 and VT/Ti0.5/1.5 significantly correlated with FEV1.0/FVC. The findings suggest that the parameters of the respiratory pattern may change depending on respiratory rates, and that the ratios of those parameters obtained at two different rates could be helpful in diagnosing airflow obstruction.
authors.affiliation: Division of Respiratory Disease, Institute of Clinical Medicine, University of Tsukuba, Ibaraki.
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Homma
authors.forename: H
authors.initials: H
authors.lastname: Aoki
authors.forename: M
authors.initials: M
authors.lastname: Sumi
authors.forename: I
authors.initials: I
authors.lastname: Ohtsu
authors.forename: S
authors.initials: S
authors.lastname: Tomioka
authors.forename: M
authors.initials: M
authors.lastname: Hagiya
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D012119:Respiration / Q000502:physiology*; D012129:Respiratory Function Tests; D013990:Tidal Volume; D014057:Tomography, X-Ray Computed