Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens.
Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.
Herold
B C
BC
Section of Pediatric Infectious Diseases, University of Chicago, Illinois 60637-1470, USA. bherold@midway.uchicago.edu
Siston
A
A
Bremer
J
J
Kirkpatrick
R
R
Wilbanks
G
G
Fugedi
P
P
Peto
C
C
Cooper
M
M
D001422:Bacterial Adhesion / Q000187:drug effects; D002241:Carbohydrates / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000517:prevention & control; D002692:Chlamydia trachomatis; D005260:Female; D006069:Gonorrhea / Q000517:prevention & control; D015658:HIV Infections / Q000517:prevention & control; D006367:HeLa Cells / Q000187:drug effects / Q000382:microbiology; D006561:Herpes Simplex / Q000517:prevention & control; D006801:Humans; D009344:Neisseria gonorrhoeae; D015231:Sexually Transmitted Diseases, Bacterial / Q000382:microbiology / Q000517:prevention & control*; D015229:Sexually Transmitted Diseases, Viral / Q000517:prevention & control* / Q000821:virology; D013431:Sulfates / Q000627:therapeutic use*
D002241:Carbohydrates; D013431:Sulfates