title: Posttransplant eosinophilic gastroenteritis in children.
abstract: The cause of eosinophilic gastroenteropathy in older children and adults is unknown. In this report, two post-liver transplantation children treated with low-dose cyclosporine A and alternate-day low-dose prednisone are described who were administered a single bolus administration of a lympholytic dose of corticosteroids without taper and who developed intestinal symptomatology several weeks later. Histologic examination of mucosal biopsy specimens from various regions of the gastrointestinal tract showed an intense eosinophilic infiltration of the mucosa and lamina propria. The patients recovered after corticosteroid administration was tapered. Post-transplant gastroenteric eosinophilic inflammation may need to be considered in patients on immunomodulatory medications who have chronic intestinal symptomatology.
authors.affiliation: Department of Pediatrics, University of Nebraska Medical Center, Center for Human Nutrition, Omaha 68198-5160, USA.
authors.forename: A
authors.initials: A
authors.lastname: Dhawan
authors.forename: T A
authors.initials: TA
authors.lastname: Seemayer
authors.forename: C
authors.initials: C
authors.lastname: Pinsinski
authors.forename: T G
authors.initials: TG
authors.lastname: Gross
authors.forename: B W
authors.initials: BW
authors.lastname: Shaw
authors.forename: D R
authors.initials: DR
authors.lastname: Mack
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D003106:Colon / Q000473:pathology; D004802:Eosinophilia / Q000209:etiology* / Q000473:pathology; D005260:Female; D005759:Gastroenteritis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011183:Postoperative Complications
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone