title: Psychological stress does not affect plasma catecholamines in subjects with cardiovascular disorder.
abstract: Whereas the effects of cardiac transplantation on the catecholamine response to physical exercise have been studied previously, the impact on psychological stress is unknown. Here, the arterial catecholamine response to the Stroop test of patients with an orthotopic heart transplant (OHT) was compared with that in subjects who had received a coronary artery bypass graft (CABG) or who were in heart failure and destined for a heart transplant (HF). Subjects were tested whilst sitting and their usual drug therapy was maintained. The Stroop test increased subjects' subjective tension but did not affect arterial concentrations of adrenaline or noradrenaline in any group of subjects. Also, the concentration of both catecholamines was significantly higher in OHT and CABG subjects than in the HF group, but their relative concentration was unaffected by cardiovascular status or stress. It is concluded that the absolute concentrations of arterial catecholamines, but not their relative concentrations, depend on clinical status. Moreover, under these test conditions, subjects with a history of cardiovascular disorder do not show the normal catecholamine response to psychological stress.
authors.affiliation: Department of Pharmacology, University College London, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Stanford
authors.forename: G
authors.initials: G
authors.lastname: Mikhail
authors.forename: P
authors.initials: P
authors.lastname: Salmon
authors.forename: D
authors.initials: D
authors.lastname: Gettins
authors.forename: S
authors.initials: S
authors.lastname: Zielinski
authors.forename: J R
authors.initials: JR
authors.lastname: Pepper
mesh_terms: D000293:Adolescent; D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood* / Q000523:psychology; D002395:Catecholamines / Q000097:blood*; D001026:Coronary Artery Bypass / Q000523:psychology; D004837:Epinephrine / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000523:psychology; D016027:Heart Transplantation / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D013315:Stress, Psychological / Q000097:blood*
chemical_list: D002395:Catecholamines; D009638:Norepinephrine; D004837:Epinephrine