Epidermal naevi associated with trichilemmal cysts and chromosomal mosaicism.
We present the case of a 29-year-old woman who has had a widespread epidermal naevus since birth, located on the left side of her body, upon which multiple trichilemmal cysts developed several years later. The karyotype of peripheral blood lymphocytes revealed chromosomal mosaicism 46, XX, t (1;9) (p36:q34). The possible pathogenic mechanisms include paracrinopathy, germinal or somatic mutation in the multipotential embryo cells, or a combination of the two.
Iglesias Zamora
M E
ME
Department of Dermatology, University Hospital, School of Medicine, University of Navarra, Pamplona, Spain.
Vázquez-Doval
F J
FJ
D000328:Adult; D004814:Epidermal Cyst / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D009030:Mosaicism; D009506:Nevus / Q000150:complications / Q000235:genetics* / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology