title: Delayed hypersensitivity reaction to vancomycin.
abstract: The use of vancomycin has increased dramatically in recent years with the emergence of methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci as important hospital pathogens. A patient receiving vancomycin 1.75 g intravenously as a single daily dose developed a syndrome characterized by high fever, erythema multiforme, eosinophilia, and presumed interstitial nephritis. This delayed hypersensitivity reaction resolved with discontinuation of the drug and treatment with methylprednisolone.
authors.affiliation: Department of Critical Care Medicine, St. Vincent Hospital and University of Massachusetts Medical School, Worcester 01604, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Marik
authors.forename: N
authors.initials: N
authors.lastname: Ferris
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000503:physiopathology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000150:complications / Q000188:drug therapy; D014640:Vancomycin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin