Facilitation of AVP(4-8) on gene expression of BDNF and NGF in rat brain.
In situ hybridization and Northern blot assay were used to evaluate the effects of exogenous AVP(4-8) on the transcription of mRNAs for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) in the adult rat brain. NGF and BDNF expression was found to be significantly enhanced by AVP(4-8) administration in the cerebral cortex and hippocampus, but NT-3 expression was not changed. In the same conditions, behavior-active arginine-vasopressin (AVP) showed a small effect and its behavior-inactive homologue, oxytocin did not. Our results suggest that selective regulation of neurotrophin gene expression by the peptides may be responsible for its memory-enhancing function.
Zhou
A W
AW
Shanghai Institute of Biochemistry, Chinese Academy of Sciences, People's Republic of China.
Li
W X
WX
Guo
J
J
Du
Y C
YC
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015152:Blotting, Northern; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis* / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D017403:In Situ Hybridization; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D020933:Neurotrophin 3; D010446:Peptide Fragments / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D016372:RNA, Antisense / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D014158:Transcription, Genetic
D019208:Brain-Derived Neurotrophic Factor; D018076:DNA, Complementary; D009414:Nerve Growth Factors; D020933:Neurotrophin 3; D010446:Peptide Fragments; D016372:RNA, Antisense; D012333:RNA, Messenger; D001127:Arginine Vasopressin; C052436:argipressin (4-9), (3-1')-disulfide Cys(6)-; D011761:Pyrrolidonecarboxylic Acid