title: Diagnosis of endolymphatic hydrops by low-frequency masking.
abstract: Low-frequency masking is a new method for the diagnosis of endolymphatic hydrops. A short acoustic stimulus and a low-frequency masker tone are applied to the same ear in an adjustable phase relationship. We recorded phase-dependent masked thresholds from normal-hearing subjects, and patients with Ménière's disease and sensory hearing loss without vertigo. In normal hearing, there is a mean maximal difference in masking (modulation depth) of 28 dB between the phase delays of 0 degree and 270 degrees. In patients with sensory hearing loss without vertigo, modulation depth is reduced due to recruitment. In Ménière cases, the phase dependence may be totally absent and varies as the disease progresses. Therefore, repeated measurements of masking are required: patients and subjects with normal hearing were tested for a period of 1 year. Also, modulation depth is significantly reduced in the contralateral nonsymptomatic ears of Ménière patients. The results indicate that low-frequency masking is a quick, noninvasive and relevant method for the diagnosis of endolymphatic hydrops.
authors.affiliation: ENT Department, Virchow Hospital, Humboldt University, Berlin, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Mrowinski
authors.forename: G
authors.initials: G
authors.lastname: Scholz
authors.forename: S
authors.initials: S
authors.lastname: Krompass
authors.forename: K
authors.initials: K
authors.lastname: Nubel
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D001309:Auditory Threshold / Q000502:physiology; D001933:Brain Stem / Q000503:physiopathology; D003937:Diagnosis, Differential; D018159:Endolymphatic Hydrops / Q000175:diagnosis* / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D010470:Perceptual Masking / Q000502:physiology*; D010898:Pitch Perception / Q000502:physiology*