The use of biomaterials in the repair of abdominal wall defects: a comparative study between polypropylene meshes (Marlex) and a new polytetrafluoroethylene prosthesis (Dual Mesh).
In this study we compared the behaviour of the non-porous on one side ePTFE Dual Mesh prosthesis and the macroporous polypropylene mesh Marlex in the repair of abdominal wall defects in rabbits. We evaluated the degree of integration with recipient tissue, biological tolerance, adhesion formation with viscera and the biomechanical resistance of the repair zone. Our results showed good biological tolerance of both prostheses and a high degree of adhesion formation in Marlex implants. In animals with Dual Mesh implants, only loose adhesions were seen. Marlex implants induced the presence of disorganized scar tissue, while the Dual Mesh prostheses were encapsulated by organized tissue. The macrophage response was similar in both decreasing with time. The resistance to traction was higher when the reparation was done with polypropylene. We concluded that the structure of the prosthesis determines its degree of integration and the resistance to traction of the repaired zone.
Bellón
J M
JM
Department of Morphological Sciences and Surgery, University of Alcalá de Henares, Madrid, Spain.
Contreras
L A
LA
Buján
J
J
Carrera-San Martín
A
A
D000009:Abdominal Muscles / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002921:Cicatrix / Q000209:etiology; D003238:Connective Tissue / Q000473:pathology; D004867:Equipment Design; D005500:Follow-Up Studies; D005549:Foreign-Body Reaction / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010537:Peritoneum / Q000473:pathology / Q000601:surgery; D011095:Polyethylenes / Q000737:chemistry; D011126:Polypropylenes / Q000737:chemistry; D011138:Polytetrafluoroethylene / Q000737:chemistry; D011183:Postoperative Complications; D011474:Prosthesis Design; D011817:Rabbits; D013314:Stress, Mechanical; D013499:Surface Properties; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000209:etiology
D001672:Biocompatible Materials; C016674:Plastipore; D011095:Polyethylenes; D011126:Polypropylenes; D011138:Polytetrafluoroethylene