The DNA polymerase alpha-primase complex couples DNA replication, cell-cycle progression and DNA-damage response.
The highly conserved DNA polymerase alpha-primase complex (pol-prism) is the only eukaryotic DNA polymerase that can initiate DNA synthesis de novo. It is required both for the initiation of DNA replication at chromosomal origins and for the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. The dual role of pol-prim makes it a likely target for mechanisms that control cell-cycle S-phase entry and progression.
Foiani
M
M
Dipartimento di Genetica e di Biologia dei Microrganismi, Università degli Studi di Milano, Italy. foianim@imiucca.csi.unimi.it
Lucchini
G
G
Plevani
P
P
D000818:Animals; D002453:Cell Cycle; D004249:DNA Damage; D019915:DNA Primase / Q000378:metabolism*; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D006801:Humans
D019915:DNA Primase; D004259:DNA-Directed DNA Polymerase