title: Risks for bacteremia and urinary tract infections in young febrile children with bronchiolitis.
abstract: OBJECTIVE
  To compare the risks for bacteremia and urinary tract injections (UTI) in young febrile children with and without bronchiolitis.
  
  
  METHODS
  A prospective cohort study.
  
  
  METHODS
  The emergency departments of 3 pediatric referral hospitals.
  
  
  METHODS
  A convenience sample of 432 previously healthy febrile patients aged 24 months or younger. Patients were divided into groups, based on the presence (n = 163, bronchiolitis group) or absence (n = 269, control group) of wheezing and/or retractions on examination. Blood cultures were obtained from all patients, and urine cultures were obtained from female patients, and male patients aged 6 months or younger. Chest radiographs were obtained on patients with lower respiratory tract signs, and those with lobar pneumonias were excluded (7 wheezing and 8 nonwheezing patients), leaving 156 patients with bronchiolitis and 261 control patients.
  
  
  METHODS
  Growth of any bacterial pathogens from the blood or 10(4) colony-forming units per milliliter or more from the urine.
  
  
  RESULTS
  None of the 156 patients with bronchiolitis had bacteremia (95% confidence interval, 0%-1.9%) vs 2.7% of the 261 controls (95% confidence interval, 1.1%-5.4%; P = .049); 1.9% of the patients with bronchiolitis had UTI vs 13.6% of the controls (odds ratio, 0.12; 95% confidence interval, 0.02-0.55; P = .001). None of the subset of patients with bronchiolitis aged 2 months or younger (n = 36) had bacteremia or UTI; however, there were not enough of these younger patients to make statistically conclusive comparisons.
  
  
  CONCLUSIONS
  Previously healthy febrile children aged 24 months or younger with bronchiolitis are unlikely to have bacteremia or UTI. Therefore, routine cultures of the blood and urine in these patients are unnecessary. More data are needed regarding the subset of febrile infants aged 2 months or younger with bronchiolitis.
authors.affiliation: nkuppermann@ucdavis.edu
authors.forename: N
authors.initials: N
authors.lastname: Kuppermann
authors.forename: D E
authors.initials: DE
authors.lastname: Bank
authors.forename: E A
authors.initials: EA
authors.lastname: Walton
authors.forename: M O
authors.initials: MO
authors.lastname: Senac
authors.forename: I
authors.initials: I
authors.lastname: McCaslin
mesh_terms: D016470:Bacteremia / Q000175:diagnosis* / Q000382:microbiology*; D001988:Bronchiolitis / Q000097:blood* / Q000652:urine*; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005334:Fever / Q000150:complications* / Q000382:microbiology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D001936:Moraxella catarrhalis / Q000302:isolation & purification; D011446:Prospective Studies; D012307:Risk Factors; D012477:Salmonella enteritidis / Q000302:isolation & purification; D013292:Streptococcus agalactiae / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000150:complications* / Q000175:diagnosis*