title: Determination of the distribution of malathion in rats following various routes of administration by whole-body electronic autoradiography.
abstract: The distribution of [14C]-malathion, an organophosphorus pesticide, in rats after intravenous, oral and dermal administration was carried out using electronic autoradiography of whole body sections of treated animals. The study indicated that a major difference in the disposition of [14C]-malathion occurred following various routes of administration to rats. Following intravenous administration, the liver and kidney accumulated extremely high levels of the chemical. After oral administration, [14C]-malathion absorption from the stomach was slow and its excretion followed mostly the fecal route. Dermal application of [14C]-malathion may represent a high risk for exposure to the organophosphorus pesticide where the entire skin, not only the site of application, may act as reservoir for the compound.
authors.affiliation: Department of Chemistry, Texas Southern University, Houston 77004, USA. mahmoud-saleh@classic.msn.com
authors.forename: M A
authors.initials: MA
authors.lastname: Saleh
authors.forename: A E
authors.initials: AE
authors.lastname: Ahmed
authors.forename: A
authors.initials: A
authors.lastname: Kamel
authors.forename: C
authors.initials: C
authors.lastname: Dary
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography / Q000379:methods*; D004582:Electronics, Medical; D007275:Injections, Intravenous; D007306:Insecticides / Q000493:pharmacokinetics*; D008294:Malathion / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D007306:Insecticides; D008294:Malathion