title: Short-term effect of portal vein arterialization on hepatic protein synthesis and endotoxaemia after extended hepatectomy in dogs.
abstract: To assess the effect of partial portal arterialization on the remaining liver after usually lethal extended hepatectomy, 30 mongrel dogs underwent 84% partial hepatectomy and were divided into three groups as follows: group 1, 84% partial hepatectomy (n = 10); group 2, 84% partial hepatectomy and splenectomy (n = 10); group 3, 84% partial hepatectomy and splenectomy and splenic artery-vein (A-V) shunt (n = 10). Another five dogs were pre-operatively killed normal controls. Portal vein flow (PVF) decreased to about 60% in groups 1 and 2, but PVF in group 3 was maintained at the pre-operative level. Oxygen saturation of portal vein blood increased markedly, to between 83% (group 1) and 88% (group 3). Portal vein pressure (PVP) increased in groups 1 and 2 by 1.6 to 1.7 times the pre-operative value, but no significant difference in PVP, serum aspartate aminotransferase (AST) and arterial ketone body ratio was found between the three groups. Plasma endotoxin levels after 84% partial hepatectomy were significantly lower in group 3 than in groups 1 and 2. Both of hepatocellular and secretory protein synthesis were enhanced in group 3 compared with the other two groups. These results suggest that partial portal arterialization using a splenic A-V shunt might bring about a beneficial effect on remaining liver function after extended hepatectomy.
authors.affiliation: First Department of Surgery, School of Medicine, Chiba University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ogata
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: S
authors.initials: S
authors.lastname: Ohtawa
authors.forename: M
authors.initials: M
authors.lastname: Ohtsuka
authors.forename: N
authors.initials: N
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D004285:Dogs; D004731:Endotoxins / Q000097:blood*; D006498:Hepatectomy; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D011169:Portal Vein / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D014176:Protein Biosynthesis; D012039:Regional Blood Flow / Q000502:physiology; D013154:Spleen / Q000098:blood supply; D013997:Time Factors
chemical_list: D004731:Endotoxins; D001219:Aspartate Aminotransferases; D007930:Leucine; D010100:Oxygen