Protective effects of the lipophilic redox conjugate tocopheryl succinyl-ethyl ferulate on HIV replication.
Previously, we demonstrated that ferulate ethyl and tocopherol reduced HIV replication. In this study, we investigate whether the conjugation of both compounds (O-tocopheryl succinyl O-ethyl ferulate) can increase HIV inhibition. We show here for the first time that O-tocopheryl succinyl O-ethyl ferulate inhibits 80% of HIV replication (HIV-1 acute infection and HIV transmission), inhibits cell lipoperoxidation and prevents cellular glutathione consumption. Compared to ferulate ethyl and tocopheryl succinyl, O-tocopheryl succinyl O-ethyl ferulate inhibits more HIV replication. This may be due in part to the great increase in the lipophilicity of this compound.
Edeas
M A
MA
Département de Biochimie, Hôpital Antoine Béclère, Clamart, France.
Claise
C
C
Vergnes
L
L
Khalfoun
Y
Y
Barthelemy
S
S
Labidalle
S
S
Lindenbaum
A
A
D002109:Caffeic Acids / Q000494:pharmacology; D002460:Cell Line; D002478:Cells, Cultured; D003373:Coumaric Acids / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D016655:HIV Core Protein p24 / Q000032:analysis; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000502:physiology* / Q000821:virology*; D009000:Monocytes / Q000166:cytology; D014779:Virus Replication / Q000187:drug effects*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D002109:Caffeic Acids; D003373:Coumaric Acids; D016655:HIV Core Protein p24; C109665:O-tocopherylsuccinyl O-ethyl ferulate conjugate; D014801:Vitamin A; D014810:Vitamin E; C099085:ethyl ferulate; D005978:Glutathione