title: Persistent cortical blindness after cyclosporine leukoencephalopathy.
abstract: Cyclosporine A (CyA)-related cortical blindness is an uncommon complication of CyA therapy in patients undergoing liver transplantation. Characteristically, neurological symptoms associated with CyA treatment usually regress after cyclosporine withdrawal. We present a case of a liver transplant recipient in whom discontinuation of CyA therapy has resulted in only partial clinical improvement, and cortical blindness remains after 1 year of follow-up. The evolution of cerebral magnetic resonance imaging (MRI) findings over time in this form of CyA leukoencephalopathy is also described.
authors.affiliation: Neurology Service, Hospital Universitari La Fe, València, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Casanova
authors.forename: M
authors.initials: M
authors.lastname: Prieto
authors.forename: E
authors.initials: E
authors.lastname: Deya
authors.forename: C
authors.initials: C
authors.lastname: Gisbert
authors.forename: J
authors.initials: J
authors.lastname: Mir
authors.forename: J
authors.initials: J
authors.lastname: Berenguer
authors.forename: J J
authors.initials: JJ
authors.lastname: Vilchez
mesh_terms: D019575:Blindness, Cortical / Q000139:chemically induced*; D001927:Brain Diseases / Q000139:chemically induced*; D016572:Cyclosporine / Q000009:adverse effects*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D017093:Liver Failure / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine