title: [Effect of rhG-CSF on platelets using in vitro bleeding time and transcranial Doppler examination].
abstract: There is experimental evidence for recombinant human granulocyte colony-stimulating factor (rhG-CSF)-induced stimulation of hemostaseologic parameters including platelets. Using the closure time of the in vitro bleeding test (IVBT, Thrombostat 4000, VDG, Seeon) and different hemostaseologic parameters, our results are suggestive of a directly or indirectly induced in vivo stimulation of platelets following rhG-CSF stimulation in healthy stem cell donors. According to the negative transcranial Doppler microembolic monitoring of the middle cerebral artery, there is no evidence for clinically silent cerebral microembolism supporting a prothrombotic state facilitating the formation of arterial thrombi with subsequent cerebral embolization.
authors.affiliation: Klinik für Hämatologie, Onkologie, Heinrich-Heine-Universität Düsseldorf, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Söhngen
authors.forename: M
authors.initials: M
authors.lastname: Siebler
authors.forename: S
authors.initials: S
authors.lastname: Wienen
authors.forename: G
authors.initials: G
authors.lastname: Kobbe
authors.forename: K
authors.initials: K
authors.lastname: Hollmig
authors.forename: P
authors.initials: P
authors.lastname: Schneider
authors.forename: C
authors.initials: C
authors.lastname: Boogen
authors.forename: A
authors.initials: A
authors.lastname: Heyll
authors.forename: W
authors.initials: W
authors.lastname: Schneider
mesh_terms: D000293:Adolescent; D000328:Adult; D001760:Bleeding Time; D001782:Blood Donors; D001792:Blood Platelets / Q000187:drug effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000097:blood* / Q000000981:diagnostic imaging; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D010979:Platelet Function Tests; D011994:Recombinant Proteins; D012307:Risk Factors; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor