title: Percutaneous biliary drainage: clinical trial of analgesia with interpleural block.
abstract: OBJECTIVE
  To determine the analgesic efficacy and safety of interpleural block for percutaneous biliary drainage.
  
  
  METHODS
  In this double-blind study, 34 age- and sex-matched patients who were to undergo percutaneous biliary drainage because of malignant biliary obstruction were randomly assigned to the true-block group (30 mL 0.5% bupivacaine block) or placebo-block group; all had access to a patient-controlled analgesia (fentanyl) pump. Self medication, pain reports, blood pressure, heart rate, and oxygen saturation were monitored during and until 8 hours after drainage. The McGill Pain Questionnaire was administered 1 hour after biliary drainage.
  
  
  RESULTS
  Patients in the placebo group self administered statistically significantly more fentanyl than did patients in the true-block group (P = .008). Peak pain scores (10-point scale) and McGill Pain Questionnaire scores were statistically significantly higher for the placebo group patients (P = .017 and P = .001, respectively). There were no differences between groups in terms of blood pressure, heart rate, and oxygen saturation. Two patients had pneumothorax caused by the interpleural block.
  
  
  CONCLUSIONS
  Interpleural block was effective in decreasing pain and opioid requirements during and after percutaneous biliary drainage and did not compromise the cardiopulmonary status of the patient. However, the rate of pneumothorax was higher than previously reported.
authors.affiliation: Department of Radiology, University of Montreal Medical Center, Quebec, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Therasse
authors.forename: M
authors.initials: M
authors.lastname: Choinière
authors.forename: G
authors.initials: G
authors.lastname: Soulez
authors.forename: V L
authors.initials: VL
authors.lastname: Oliva
authors.forename: P
authors.initials: P
authors.lastname: Rousseau
authors.forename: F
authors.initials: F
authors.lastname: Fugère
authors.forename: D
authors.initials: D
authors.lastname: Boudreault
authors.forename: J R
authors.initials: JR
authors.lastname: Cusson
mesh_terms: D000368:Aged; D000698:Analgesia / Q000009:adverse effects / Q000379:methods; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D002045:Bupivacaine; D002779:Cholestasis / Q000628:therapy*; D004311:Double-Blind Method; D004322:Drainage / Q000379:methods*; D005260:Female; D005283:Fentanyl; D006801:Humans; D008297:Male; D009407:Nerve Block / Q000009:adverse effects / Q000379:methods; D010147:Pain Measurement; D010994:Pleura; D011030:Pneumothorax / Q000209:etiology
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D005283:Fentanyl; D002045:Bupivacaine