Gastrin-releasing peptide1-27, unlike bombesin, does not reduce sham feeding in rats.
We compared the potencies of systemic administration of bombesin (BN) and its mammalian homologue gastrin-releasing peptide (GRP) to decrease sham feeding in rats. Bombesin (at doses of 8, 16 and 32 micrograms/kg, intraperitoneally) inhibited sham feeding by 37% (p < 0.001), 58% (p < 0.001) and 65% (p < 0.001), respectively, confirming previous results. Gastrin-releasing peptide (16, 32, and 64 micrograms/kg) failed to affect sham feeding. Bombesin (16 micrograms/kg) and gastrin-releasing peptide (32 micrograms/kg) inhibited real feeding by 64% (p < 0.001) and 44% (p < 0.004), respectively. Pregastric food stimulation is not sufficient for the inhibitory action of GRP.
Smith
J
J
Department of Psychiatry, Cornell University Medical College, NY, USA.
Perez
S
S
Rushing
P A
PA
Smith
G P
GP
Gibbs
J
J
D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D019886:Gastrin-Releasing Peptide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D019886:Gastrin-Releasing Peptide; D001839:Bombesin