title: Evolutionary history of the 11p15 human mucin gene family.
abstract: The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. In contrast, little information is available concerning MUC6. These Cys-subdomains contain 10 cysteine residues that have a highly conserved position. We present here a coherent probable evolutionary history of this human gene family after comparison of the nucleotide sequences of these Cys-subdomains. The three MUC loci MUC2, MUC5AC, and MUC5B may have evolved from a common ancestral gene by two successive duplications. Moreover, we can postulate that MUC5AC and MUC5B have evolved in a concerted manner, while MUC2 has evolved separately.
authors.affiliation: INSERM U377 Laboratoire Gérard Biserte, place de Verdun, 59045 Lille Cedex, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Desseyn
authors.forename: M P
authors.initials: MP
authors.lastname: Buisine
authors.forename: N
authors.initials: N
authors.lastname: Porchet
authors.forename: J P
authors.initials: JP
authors.lastname: Aubert
authors.forename: P
authors.initials: P
authors.lastname: Degand
authors.forename: A
authors.initials: A
authors.lastname: Laine
mesh_terms: D001483:Base Sequence; D002880:Chromosomes, Human, Pair 11; D017124:Conserved Sequence; D019143:Evolution, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D055271:Mucin 5AC; D055262:Mucin-2; D055257:Mucin-5B; D009077:Mucins / Q000235:genetics*
chemical_list: C524625:MUC2 protein, human; C524678:MUC5AC protein, human; C524578:MUC5B protein, human; D055271:Mucin 5AC; D055262:Mucin-2; D055257:Mucin-5B; D009077:Mucins