title: Sparfloxacin: potential clinical and economic impact in the treatment of respiratory infections.
abstract: Sparfloxacin is a new oral fluoroquinolone antimicrobial that is highly active against common respiratory pathogens, including multiresistant strains. It is well absorbed and has excellent penetration into upper and lower respiratory tissues. Sparfloxacin is administered once a day and does not interfere with the metabolism of other drugs. The agent is highly effective and safe in the treatment of acute sinusitis, exacerbations of chronic bronchitis, and community-acquired pneumonia. Due to its activity against multidrug-resistant respiratory pathogens, it has the potential to prevent hospitalization as well as decrease parenteral antibiotic therapy. Consequently, it may generate significant pharmacoeconomic benefits to patients and payers of medical care.
authors.affiliation: Department of Medicine, Michigan State University, East Lansing 48824, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Stein
authors.forename: D H
authors.initials: DH
authors.lastname: Havlichek
mesh_terms: D000890:Anti-Infective Agents / Q000191:economics* / Q000627:therapeutic use*; D024841:Fluoroquinolones; D006801:Humans; D015363:Quinolones / Q000191:economics* / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000191:economics*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C061363:sparfloxacin