title: Bard BTA test compared with voided urine cytology in the diagnosis of recurrent bladder cancer.
abstract: OBJECTIVE
  To compare the Bard BTA (bladder tumour antigen) test with voided urine cytology (VUC) in the diagnosis of recurrent bladder cancer (BC).
  
  
  METHODS
  Urine specimens for the BTA test and VUC were collected on the same day as before cystoscopy from patients undergoing routine surveillance cystoscopy for recurrent BC. The pathologists performing VUC were blinded to the results of the BTA test.
  
  
  RESULTS
  BC was identified by cystoscopy and biopsy in 39 of 164 study participants. The overall sensitivities of the BTA test and VUC were 54 and 28%, respectively (p < 0.05). The BTA test was more sensitive than VUC for all tumour stages and grades. For > or = T2 tumours and grade 3 tumours, respectively, the difference was statistically significant (p < 0.05). The specificities of the BTA test and VUC were 92 and 97%, respectively. Both a false-positive BTA test and VUC were found to predict recurrence.
  
  
  CONCLUSIONS
  The BTA test is equal or superior to VUC in the detection of BC in patients undergoing routine surveillance for recurrent BC.
authors.affiliation: Technical University of Munich, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Leyh
authors.forename: E
authors.initials: E
authors.lastname: Mazeman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis* / Q000276:immunology / Q000652:urine; D003558:Cystoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000652:urine; D014554:Urination; D014556:Urine / Q000166:cytology*
chemical_list: D000951:Antigens, Neoplasm