title: Effects of quinapril on coronary blood flow in coronary artery disease patients with endothelial dysfunction. TREND Investigators. Trial on Reversing Endothelial Dysfunction.
abstract: This pilot study evaluates the effects of quinapril, an angiotensin-converting enzyme inhibitor with high tissue-binding affinity, on microvascular endothelial function in patients with mild (<40% narrowing) coronary artery disease and epicardial endothelial dysfunction. Patients randomized to quinapril had a trend suggesting an increase in endothelium-dependent coronary blood flow response.
authors.affiliation: Department of Medicine, University of Florida, Gainesville 32610-0277, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Schlaifer
authors.forename: T J
authors.initials: TJ
authors.lastname: Wargovich
authors.forename: B
authors.initials: B
authors.lastname: O'Neill
authors.forename: G B
authors.initials: GB
authors.lastname: Mancini
authors.forename: H E
authors.initials: HE
authors.lastname: Haber
authors.forename: B
authors.initials: B
authors.lastname: Pitt
authors.forename: C J
authors.initials: CJ
authors.lastname: Pepine
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000241:Adenosine / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology; D010865:Pilot Projects; D000077583:Quinapril; D044005:Tetrahydroisoquinolines; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D014665:Vasodilator Agents; D005996:Nitroglycerin; D000241:Adenosine; D000109:Acetylcholine; D000077583:Quinapril