Effect of topically applied sulphur mustard on guinea pig liver.
The study revealed that topically applied sulphur mustard, which is a potent blistering agent with mutagenic and carcinogenic properties, is also hepatotoxic. It produces severe steatosis and other pathological alterations, accompanied by biochemical changes. There is a significant rise in the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT) after exposure. The liver injury appeared to peak on the third day. Recovery at the ultrastructural level could be noticed on the sixth day but was far from complete because the gross pathological changes were still severe.
Chauhan
R S
RS
Defence Research and Development Establishment, Gwalior, India.
Murty
L V
LV
D000287:Administration, Topical; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D009151:Mustard Gas / Q000008:administration & dosage / Q000633:toxicity*; D015388:Organelles / Q000187:drug effects / Q000648:ultrastructure
D002273:Carcinogens; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D009151:Mustard Gas