title: [Exposure testing with powdered gloves in 60 health care workers with latex allergy].
abstract: OBJECTIVE
  Type 1 sensitization to natural rubber latex occurs in up to 22% of health care workers. Most sensitizations are due to the use of powdered latex gloves. Work place-associated exposure tests were performed to ascertain how frequently persons who developed breathing difficulties, rhinitis/conjunctivitis or obstructive respiratory tract illness when using powdered latex gloves are allergic to latex.
  
  
  METHODS
  60 persons (48 women and 12 men; mean age 29 +/- 7 years) with type 1 sensitization to natural rubber latex were studied. The past history was obtained through a questionnaire specially designed for those with latex allergy. Diagnostic measures included prick tests with different latex allergens, measuring the concentrations of total and latex-specific IgE and exposure trials, related to the work place, with powdered vinyl and latex gloves.
  
  
  RESULTS
  The prick tests with various latex allergens produced significant skin reactions in 59 subjects, 58 had latex-specific IgE antibodies (0.47 kU/l- > 100 kU/l). Exposure tests with powdered latex gloves produced rhinitis in 55 and conjunctivitis in 38 persons, urticaria in 3 and cough in 19. Whole-body plethysmography demonstrated a significant rise in respiratory tract resistance in 13, a reduction in 1-second expiratory volume of at least 20% in 15. Abnormal values in both tests were noted in 8 subjects.
  
  
  CONCLUSIONS
  The breathing difficulty reported by all subjects was in most cases due not to bronchial obstruction but to obstructed nasal breathing. In cases with breathing difficulty on exposure to latex gloves a latex allergy should be considered as the cause. Powdered latex gloves present a danger to health care personnel and should no longer be used.
authors.affiliation: Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Ruhr-Universität Bochum. allmers@bgfa.ruhr-uni-bochum.de
authors.forename: H
authors.initials: H
authors.lastname: Allmers
authors.forename: H
authors.initials: H
authors.lastname: Huber
authors.forename: C
authors.initials: C
authors.lastname: Wirtz
authors.forename: B
authors.initials: B
authors.lastname: Kirchner
authors.forename: M
authors.initials: M
authors.lastname: Raulf-Heimsoth
authors.forename: X
authors.initials: X
authors.lastname: Baur
mesh_terms: D000328:Adult; D000336:Aerosols; D005260:Female; D017575:Gloves, Protective; D006282:Health Personnel; D006801:Humans; D007840:Latex / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis* / Q000209:etiology; D010993:Plethysmography, Whole Body; D011208:Powders; D012130:Respiratory Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D012882:Skin Tests / Q000706:statistics & numerical data; D013997:Time Factors
chemical_list: D000336:Aerosols; D007840:Latex; D011208:Powders