title: Allergic nephropathy associated with norfloxacin and ciprofloxacin therapy. Report of two cases and review of the literature.
abstract: Allergic nephropathy associated with quinolone antibiotics has been reported in an increasing number of cases. The mechanism might be a hypersensitivity reaction. Norfloxacin has been incriminated previously as a cause once only, with acute interstitial nephritis (AIN) as the histopathological finding. Ciprofloxacin-associated nephropathy has been reported in 28 cases, with AIN as the main histopathological finding. This report describes a second case of AIN associated with norfloxacin treatment and another ciprofloxacin-associated renal interstitial drug adverse reaction. Clinicians should be aware of quinolone-associated AIN, which is a rare but potentially dangerous renal complication.
authors.affiliation: Department of Internal Medicine, Eksjö County Hospital, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Hadimeri
authors.forename: G
authors.initials: G
authors.lastname: Almroth
authors.forename: K
authors.initials: K
authors.lastname: Cederbrant
authors.forename: S
authors.initials: S
authors.lastname: Eneström
authors.forename: P
authors.initials: P
authors.lastname: Hultman
authors.forename: A
authors.initials: A
authors.lastname: Lindell
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D009643:Norfloxacin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D009643:Norfloxacin