title: Changes in structural and functional properties of rat intestinal brush border membrane during starvation.
abstract: Changes in surface area of microvilli, fluidity of brush border membrane and transport of L-amino acids through intestinal epithelial cells were studied in wellfed and starved (2,4 and 6 days) rats. The surface area of microvilli per unit area of intestinal epithelial cells increased during starvation. Studies with fluoroprobes - pyrene, 1-anilinonaphthalene-8-sulphonate and 1,6-diphenyl-1,3,5-hexatriene, showed increased fluidity of brush border membrane on progressive starvation. Transport of five amino acids representing five different transport systems was studied during starvation in everted intestinal sleeves. Transport of L-proline, glycine and L-glutamic acid which represent imino, glycine and acidic systems respectively increased significantly in Na+-dependent pathway whereas transport of L-lysine representing basic system increased significantly in Na+-independent pathway during starvation.
authors.affiliation: Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: A A
authors.initials: AA
authors.lastname: Waheed
authors.forename: P D
authors.initials: PD
authors.lastname: Gupta
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D001835:Body Weight; D007422:Intestines / Q000502:physiology / Q000648:ultrastructure*; D008297:Male; D008560:Membrane Fluidity; D008871:Microvilli / Q000502:physiology / Q000648:ultrastructure; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013217:Starvation
chemical_list: D000596:Amino Acids