[Effect of arginine vasopressin (AVP) inhibitor in the inhibition of the peritumoral edema].
We investigated the effect of RU599 Arginine Vasopressin (AVP) inhibitor on peritumoral edema of Wistar rats implanted with C6 glioma. C6 glioma was implanted into the right caudoputamen of 3 week-old rat's brain. Five weeks after the implantation, the changes of the brain water contents were measured by the dry-weight method. RU599 (1 mg/ml/kg body weight) was administered into Wistar rats via the tail vein every one hour (total 4 times), and the same dose of saline was used as control. Rats were sacrificed 1 hour after the last administration, and the brain of each rat was divided into 3 parts such as the anterior part without a tumor, the middle part with a tumor and the posterior part without a tumor. After that each part was separated into the right and left parts. The tumor was removed from the brain. The water contents of the brain were increased in the area around the tumor and the contralateral cerebral hemisphere excluding the anterior part. RU599 could reduce the increased water contents significantly in all areas except in the tumor itself and the area surrounding the tumor. Tumor-origin brain edema includes not only localized one but also diffuse one in the brain, and this study suggests RU599 has an effect of inhibiting the diffuse brain edema.
Hamada
H
H
Department of Neurosurgery, Nippon Medical School, Tokyo, Japan.
Takahashi
H
H
Teramoto
A
A
Yoshii
T
T
D000818:Animals; D001127:Arginine Vasopressin / Q000037:antagonists & inhibitors*; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D001932:Brain Neoplasms / Q000150:complications*; D005260:Female; D005910:Glioma / Q000150:complications; D007189:Indans / Q000627:therapeutic use*; D009578:Nitrobenzenes / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D007189:Indans; D009578:Nitrobenzenes; C110135:RU 599; D001127:Arginine Vasopressin