The effect of pregnancy on cyclosporine levels in renal allograft patients.
OBJECTIVE
To assess the effects of pregnancy on cyclosporine levels in six renal allograft patients.


METHODS
Maternal demographic, laboratory, clinical, and perinatal outcome data were recorded in six pregnant women with previous renal allografts receiving cyclosporine immunosuppression. The cyclosporine and serum creatinine levels were measured before pregnancy, during each trimester, and postpartum.


RESULTS
The mean (standard deviation [SD]) maternal age was 29.1 (3.8) years. Parity ranged from 0 to 3. Mean serum creatinine levels tended to be lower during pregnancy than before or after, as did the mean cyclosporine levels. After adjusting for dose, five of six patients had declines in cyclosporine level during pregnancy. The mean (SD) gestational age at delivery was 37.5 (2.8) weeks with a mean (SD) birth weight of 2837 (538) g.


CONCLUSIONS
Pregnancy in patients with renal allografts can lead to a substantial decline in cyclosporine levels.
Thomas
A G
AG
Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, New York, USA.
Burrows
L
L
Knight
R
R
Panico
M
M
Lapinski
R
R
Lockwood
C J
CJ
D000328:Adult; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000097:blood* / Q000493:pharmacokinetics; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood* / Q000493:pharmacokinetics; D016030:Kidney Transplantation; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy / Q000378:metabolism*; D011264:Pregnancy Trimesters; D012098:Reproduction; D012189:Retrospective Studies; D014184:Transplantation, Homologous
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D003404:Creatinine