title: Anosognosia: examining the disconnection hypothesis.
abstract: OBJECTIVE
  To test the hypothesis that anosognosia for hemiparesis results from intrahemispheric disconnection.
  
  
  METHODS
  Using right carotid barbiturate injection as a model for anosognosia for hemiparesis, systematic attempts were made to modify deficit awareness by providing the left hemisphere with explicit information regarding left upper extremity function.
  
  
  RESULTS
  Experimental interventions failed to modify deficit awareness in 19 of 32 patients. In those patients who discovered their weakness, attempted movement of the weak limb seems more important than explicit observation of the extremity by the left hemisphere.
  
  
  CONCLUSIONS
  The results fail to support Geschwind's disconnection hypothesis for anosognosia for hemiparesis.
authors.affiliation: Department of Neurology, University of New Mexico, Albuquerque, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Adair
authors.forename: R L
authors.initials: RL
authors.lastname: Schwartz
authors.forename: D L
authors.initials: DL
authors.lastname: Na
authors.forename: E
authors.initials: E
authors.lastname: Fennell
authors.forename: R L
authors.initials: RL
authors.lastname: Gilmore
authors.forename: K M
authors.initials: KM
authors.lastname: Heilman
mesh_terms: D000328:Adult; D000377:Agnosia / Q000209:etiology*; D001463:Barbiturates / Q000008:administration & dosage / Q000494:pharmacology; D002339:Carotid Arteries; D005260:Female; D007839:Functional Laterality; D006429:Hemiplegia / Q000175:diagnosis*; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D010775:Photic Stimulation
chemical_list: D001463:Barbiturates