title: Absence of toxicity of oats in patients with dermatitis herpetiformis.
abstract: BACKGROUND
  People with gluten sensitivity should avoid foods containing wheat, rye, and barley, but there has been debate about whether they should avoid oats. Although patients with celiac disease have recently been shown to tolerate oats, less is known about the effects of oats on patients with dermatitis herpetiformis.
  
  
  METHODS
  We studied seven men and three women (mean age, 58 years) with biopsy-confirmed dermatitis herpetiformis. They had followed a strict gluten-free diet for a mean of 15.8 years, which controlled their rash and enteropathy. The patients added oats that were not contaminated with gluten to their diets for 12 weeks (mean [+/-SD] daily intake, 62.5+/-10.8 g).
  
  
  RESULTS
  None of the patients had any adverse effects. Serologic tests for antigliadin, antireticulin, and antiendomysial antibodies were negative before oats were introduced into the diet and after they were discontinued. Villous architecture remained normal: the mean (+/-SE) ratio of the height of villi to the depth of crypts was 3.59+/-0.11 before the diet and 3.71+/-0.09 afterward (normal, 3 to 5), and the mean enterocyte heights were 31.36+/-0.58 microm and 31.75+/-44 microm, respectively (normal range, 29 to 34). Duodenal intraepithelial lymphocyte counts all remained within normal limits (mean, 13.8+/-1.03 per 100 enterocytes before the diet and 14.2+/-1.2 per 100 enterocytes afterward; normal range, 10 to 30). Dermal IgA showed no significant changes.
  
  
  CONCLUSIONS
  Patients with dermatitis herpetiformis can include moderate amounts of oats in their gluten-free diets without deleterious effects to the skin or intestine.
authors.affiliation: Department of Dermatology, St. Mary's Hospital, London, United Kingdom.
authors.forename: C M
authors.initials: CM
authors.lastname: Hardman
authors.forename: J J
authors.initials: JJ
authors.lastname: Garioch
authors.forename: J N
authors.initials: JN
authors.lastname: Leonard
authors.forename: H J
authors.initials: HJ
authors.lastname: Thomas
authors.forename: M M
authors.initials: MM
authors.lastname: Walker
authors.forename: J E
authors.initials: JE
authors.lastname: Lortan
authors.forename: A
authors.initials: A
authors.lastname: Lister
authors.forename: L
authors.initials: L
authors.lastname: Fry
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D018554:Avena / Q000009:adverse effects*; D003874:Dermatitis Herpetiformis / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D004032:Diet; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007422:Intestines / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D005983:Glutens