CSF 5-HIAA and family history of antisocial personality disorder in newborns.
OBJECTIVE
The relationship between genetic liability for antisocial behavior and CSF 5-hydroxyindoleacetic acid (5-HIAA) in newborns was explored.


METHODS
The authors assayed 5-HIAA in "leftover" CSF from 193 neurologically normal newborns and obtained family psychiatric histories of the newborns' first- and second-degree relatives.


RESULTS
Levels of 5-HIAA were significantly lower in the infants with family histories of antisocial personality disorder than in the newborns without such family histories.


CONCLUSIONS
These findings support the possibility that serotonin mediates one component of genetic liability to antisocial outcome, but the magnitude of that component may be less than what has been inferred from previously published reports.
Constantino
J N
JN
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. constantino@psychiatry.wustl.edu
Morris
J A
JA
Murphy
D L
DL
D000328:Adult; D000987:Antisocial Personality Disorder / Q000453:epidemiology / Q000235:genetics*; D005190:Family; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D007231:Infant, Newborn / Q000134:cerebrospinal fluid*; D008297:Male; D012044:Regression Analysis; D012307:Risk Factors
D006897:Hydroxyindoleacetic Acid