Dosimetry of beta emitting radionuclides for use in balloon angioplasty.
The dose at varying distances from the surface of an infinite cylinder containing 90Y, 32P and 188Re respectively is calculated using published scaled point dose kernels for these three radionuclides. It is shown that all are suitable radionuclides for use in the irradiation of arteries subsequent to balloon angioplasty. All three may be used as a radioactive liquid in the angioplasty balloon, thereby simplifying the procedure and enabling a uniform radiation dose to be given to the arterial wall. It is however shown that there is a rapid reduction in dose with distance from the arterial wall which demands careful specification of the prescribed radiation dose. A similar rapid reduction with distance is also found with a central radioactive wire or with a radioactive stent containing the same radionuclides.
Fox
R A
RA
Department of Medical Physics, Royal Perth Hospital, WA. rafox@cyllene.uwa.edu.au
D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000532:radiotherapy / Q000628:therapy; D001158:Arteries / Q000293:injuries / Q000528:radiation effects; D001610:Beta Particles / Q000627:therapeutic use*; D006801:Humans; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use; D011868:Radioisotopes / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D012211:Rhenium / Q000627:therapeutic use; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
D010761:Phosphorus Radioisotopes; D011868:Radioisotopes; D015021:Yttrium Radioisotopes; D012211:Rhenium