title: Dietary selenium- and vitamin E-induced alterations in some rabbit tissues.
abstract: The present study was designed to investigate and compare the effects of dietary selenium (Se) and vitamin E on some physiological parameters and histological changes in liver, heart, and skin tissues, as well as the blood parameters and the related enzymes. Both sex young rabbits were fed with deficient (9.8 micrograms/kg diet), adequate (225 micrograms/kg diet), and rich (4.2 mg/kg diet) Se and vitamin E diets for 12-15 wk for this purpose. As the plasma Se levels and the erythrocyte glutathione (GSH) peroxidase activity decreased (79.8 +/- 9.4 ng/mL and 2.0 +/- 0.3 U/g Hb, respectively) in the deficient group, these values increased (100.4 +/- 2.7 ng/mL and 14.5 +/- 4.3 U/g Hb) in the rich group significantly with respect to the control group. The other antioxidant enzyme activities and the related element levels did not change significantly in either one of the experimental groups. Although the platelet counts of the two experimental groups were not different from the control values, the collagen and the adenosine diphosphate (ADP) stimulated platelet aggregation rate and intensity increased in the deficient group (p < 0.05) and decreased very significantly (p < 0.001) in the rich group. In both of the experimental groups, as the percentage values of the neutrophils decreased, the lymphocytes and the eosinophils increased significantly. According to the light microscopic investigations, the observed lesions of considerable intensity within the tissues that elicit cell degenerations were more pronounced in the animals fed with the rich diet than in those fed with the deficient diet. The deficiency as well as toxicity of Se and the deficiency of vitamin E caused several alterations in the physiological functions of the tissues, and these alterations were supported by the histological lesions within these tissues.
authors.affiliation: Department of Biophysics, Faculty of Medicine Ankara University, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Turan
authors.forename: N
authors.initials: N
authors.lastname: Zaloglu
authors.forename: E
authors.initials: E
authors.lastname: Koc
authors.forename: Y
authors.initials: Y
authors.lastname: Saran
authors.forename: N
authors.initials: N
authors.lastname: Akkas
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D004032:Diet; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006321:Heart / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000502:physiology; D008297:Male; D011817:Rabbits; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000172:deficiency / Q000494:pharmacology*; D012879:Skin Physiological Phenomena / Q000187:drug effects; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000097:blood / Q000503:physiopathology
chemical_list: D014810:Vitamin E; D005979:Glutathione Peroxidase; D012643:Selenium