title: Multiple colon tumors. Diagnosis and follow-up of 450 patients with colorectal carcinoma.
abstract: OBJECTIVE
  Failure to diagnose synchronous tumors leads to errors in patient treatment and prognosis. The existence of metachronous tumors requires strict patient follow-up to ensure early identification of the second tumor. The present study evaluates the results obtained in the application of a structured procedure for the diagnosis and follow-up of multiple colorectal carcinoma.
  
  
  METHODS
  A structured procedure was used to follow for 5 years a group of 12 patients with multiple colorectal tumors (7 synchronous and 5 metachronous) of a series of 450 colorectal neoplasms.
  
  
  RESULTS
  Six synchronous tumors were diagnosed preoperatively and one intraoperative. Of the 5 metachronous neoplasms, 4 strictly adhered to the follow-up protocol, as a result of which the second tumor was detected at an early stage. The remaining case involved no follow-up, and the second tumor was diagnosed in an advanced stage as a result of bowel occlusion. The left colon was predominantly involved; polyps were detected in 9 cases, while two patients had 3 malignancies detected by histopathological study.
  
  
  CONCLUSIONS
  We emphasize the need for a full evaluation of the colon in all patients with colorectal carcinoma. In the case of incomplete preoperative evaluation, intraoperative colonoscopy is to be considered; if this is not feasible it should be performed one month after surgery. A structured follow-up procedure permits the early detection of these tumors, there by improving patient prognosis.
authors.affiliation: Servicio de Cirugía General y Aparato Digestivo, Hospital General Universitario, Valencia.
authors.forename: F
authors.initials: F
authors.lastname: Villalba Ferrer
authors.forename: J C
authors.initials: JC
authors.lastname: Bernal Sprekelsen
authors.forename: C A
authors.initials: CA
authors.lastname: Fuster Diana
authors.forename: J
authors.initials: J
authors.lastname: Asensi Pérez
authors.forename: A
authors.initials: A
authors.lastname: Vázquez Prado
authors.forename: M J
authors.initials: MJ
authors.lastname: García Coret
authors.forename: F
authors.initials: F
authors.lastname: Puchades Gil
authors.forename: R
authors.initials: R
authors.lastname: Trullenque Peris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000097:blood; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D016609:Neoplasms, Second Primary / Q000175:diagnosis*
chemical_list: D002272:Carcinoembryonic Antigen