Host-versus-graft disease in mice after the induction of neonatal transplantation tolerance by two different methods.
Newborn A mice were injected either with a single i.v. dose (Group A) or with repeated doses of (B10 x A)F1 semiallogeneic spleen cells (SSC) (Group B). A similar degree of partial transplantation tolerance (TT) to B10 skin allografts was revealed in both groups. No signs of acute, rapidly fatal host-versus-graft disease (HVGD) (anemia, leukocytosis, severe thrombocytopenia, hepatic infarcts, gastrointestinal bleedings) were found, rather a chronic HVGD developed [moderate thrombocytopenia, autoimmune antithymocyte antibodies (ATA)] in both groups. The mortality due to lymphoproliferative disorders (LPD) was significantly higher in Group A. Thus, repeated perinatal injections of (B10 x A)F1 SSC into A mice did not increase the tolerogenic and the LPD-inducing effect either, and they did not elicit acute HVGD in contrast to observations in other F1 donor-recipient combinations [1]. Consequently, the development of acute HVGD depends on immunogenetic factors and not on the repeated administration of SSC.
Pipis
J
J
Department of Experimental Surgery, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Jánossy
T
T
Modok
S
S
Ocsovszki
I
I
Hidvégi
Z
Z
Horváth
G
G
Végh
P
P
Benner
R
R
D000208:Acute Disease; D000740:Anemia / Q000209:etiology; D000818:Animals; D000831:Animals, Newborn; D000961:Antilymphocyte Serum / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D017690:Cell Transplantation; D002908:Chronic Disease; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006789:Host vs Graft Reaction / Q000276:immunology*; D007108:Immune Tolerance; D007238:Infarction / Q000209:etiology; D007964:Leukocytosis / Q000209:etiology; D008099:Liver / Q000098:blood supply; D008232:Lymphoproliferative Disorders / Q000209:etiology; D051379:Mice; D008805:Mice, Inbred A; D008815:Mice, Inbred Strains; D016038:Skin Transplantation / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D015996:Survival Rate; D013921:Thrombocytopenia / Q000209:etiology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D001323:Autoantibodies