Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights.
OBJECTIVE
To analyse lymphocyte chromosomes from astronauts of MIR and EUROMIR missions.


METHODS
Peripheral lymphocytes from seven astronauts before and after space flights were cultured and analysed for structural chromosomal aberrations.


RESULTS
Chromosome-type but not chromatid-type aberrations were significantly elevated after space flights when compared to pre-flight values. In one astronaut two rogue cells were found.


CONCLUSIONS
Overall the frequencies of aberrations were found to be correlated with estimated absorbed cosmic radiation doses.
Obe
G
G
Department of Genetics, Universität GH Essen, Germany.
Johannes
I
I
Johannes
C
C
Hallman
K
K
Reitz
G
G
Facius
R
R
D018480:Astronauts; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D011829:Radiation Dosage; D013026:Space Flight