title: Propofol anesthesia and rational opioid selection: determination of optimal EC50-EC95 propofol-opioid concentrations that assure adequate anesthesia and a rapid return of consciousness.
authors.affiliation: Department of Anaesthesiology, University Hospital Leiden, The Netherlands. Jvuyk@anst.azl.nl
authors.forename: J
authors.initials: J
authors.lastname: Vuyk
authors.forename: M J
authors.initials: MJ
authors.lastname: Mertens
authors.forename: E
authors.initials: E
authors.lastname: Olofsen
authors.forename: A G
authors.initials: AG
authors.lastname: Burm
authors.forename: J G
authors.initials: JG
authors.lastname: Bovill
mesh_terms: D015760:Alfentanil / Q000493:pharmacokinetics / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000493:pharmacokinetics / Q000494:pharmacology*; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics / Q000494:pharmacology*; D003198:Computer Simulation; D004347:Drug Interactions; D005283:Fentanyl / Q000493:pharmacokinetics / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D011336:Probability; D015742:Propofol / Q000493:pharmacokinetics / Q000494:pharmacology*; D017409:Sufentanil / Q000493:pharmacokinetics / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D015760:Alfentanil; D017409:Sufentanil; D005283:Fentanyl; D015742:Propofol