[Psychobiological approach to personality disorders].
Current categorical classifications of the personality disorders are based on psychological perspectives. Consequently, biological research using these models has been unsuccessful since the nosological categories do not come out from the psychobiological systems underlying personality psychopathology. By contrast, biological research on dimensional models of personality has been more useful. All dimensional models agree on a neurotic-inhibitory dimension and an exploratory dimension of personality but they differ on other primary traits like dependence, emotionality or impulsiveness. However, gathering together all biological data support the existence of five biological axes of personality: a cognitive axis, a mood axis, an anxious-inhibitory axis, an exploratory axis and a action-control axis.


CONCLUSIONS
Considering these biological axes is bringing a new perspective on the classification of personality disorder and gives way to new pharmacological therapeutic options.
Carrasco
J L
JL
Departamento de Psiquiatría, Universidad de Salamanca. jlcp@gugu.usal.es
D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D010554:Personality Disorders / Q000145:classification* / Q000188:drug therapy; D012702:Serotonin Antagonists / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
D000929:Antidepressive Agents, Tricyclic; D001569:Benzodiazepines; D018377:Neurotransmitter Agents; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors