Localized q-space imaging of the mouse brain.
Localized q-space imaging was used to obtain water displacement profiles from mouse brain. These profiles take the form of unidirectional diffusive displacement probability distributions. Two groups of mice were studied, a normal group and a group in which surgery had been performed to produce a unilateral reduction in the supply of blood to the forebrain. q-Space measurements were made both in vivo and postmortem. The displacement profiles were characterized using the summary parameter prob[d < 10], which is the proportion of water molecules that undergo a net diffusive displacement that is less than +/-10 microm, during the diffusion period (50 ms). The range of prob[d < 10] values in the normal group was 0.71 to 0.77 in vivo compared with 0.78 to 0.87 in the impaired hemisphere of the surgically treated group. An increase in prob[d < 10] occurred postmortem to yield values in the range 0.79 to 0.81 and 0.80 to 0.89 in the normal and surgically treated group, respectively. These observations are consistent with the diffusion-weighted image intensity changes that occur after a period of ischemia.
King
M D
MD
Royal College of Surgeons Unit of Biophysics, Institute of Child Health, London, UK.
Houseman
J
J
Gadian
D G
DG
Connelly
A
A
D000818:Animals; D001923:Brain Chemistry; D002545:Brain Ischemia / Q000378:metabolism; D002560:Cerebrovascular Circulation; D004058:Diffusion; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D014867:Water / Q000032:analysis
D014867:Water