title: Restenosis after elective coronary balloon angioplasty in patients with end stage renal disease: a case-control study using quantitative coronary angiography.
abstract: OBJECTIVE
  To assess the rate of angiographic restenosis in patients with end stage renal disease after elective coronary angioplasty.
  
  
  METHODS
  A retrospective case-control study of 20 patients with end stage renal disease and 20 sex and age matched controls without renal disease, who had undergone primarily successful coronary angioplasty. Control coronary angiography was performed regardless of worsening or renewed incidence of anginal symptoms.
  
  
  METHODS
  Group comparison of coronary morphology, as evaluated by quantitative coronary angiography, and of cardiovascular risk factors.
  
  
  RESULTS
  The rate of angiographic restenosis was 60% in patients with renal disease and 35% in controls. In patients with end stage renal disease the following differences (mean (SD) were found versus controls: raised plasma fibrinogen (483 (101) v 326 (62) mg/dl, p < 0.001); raised plasma triglyceride (269 (163) v 207 (176) mg/dl, p < 0.01); smaller diameter of the coronary reference segment (2.59 (0.87) v 2.90 (0.55) mm, p < 0.10); smaller minimum luminal diameter of the dilated stenosis (0.77 (0.46) v 0.97 (0.27) mm, p < 0.05). Discriminant analysis showed that minimum luminal diameter before angioplasty (r = -0.79) and fibrinogen (r = +0.34) had the highest statistical association with restenosis.
  
  
  CONCLUSIONS
  The high rate of angiographic restenosis in patients with end stage renal disease seems to be related to the size of the vessel dilated and to an increased prothrombotic risk, as indicated by higher fibrinogen concentrations.
authors.affiliation: Medizinische Klinik, Heinrich-Heine Universität Düsseldorf, Germany. Frank-Chris.Schoebel@uni-duesseldorf.de
authors.forename: F C
authors.initials: FC
authors.lastname: Schoebel
authors.forename: F
authors.initials: F
authors.lastname: Gradaus
authors.forename: K
authors.initials: K
authors.lastname: Ivens
authors.forename: P
authors.initials: P
authors.lastname: Heering
authors.forename: T W
authors.initials: TW
authors.lastname: Jax
authors.forename: B
authors.initials: B
authors.lastname: Grabensee
authors.forename: B E
authors.initials: BE
authors.lastname: Strauer
authors.forename: M
authors.initials: M
authors.lastname: Leschke
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy*; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides; D005340:Fibrinogen; D002784:Cholesterol