title: Vasopressin-induced amber-like skin necrosis.
abstract: Case reports about vasopressin-induced cutaneous necrosis are not frequent. Here we report a further case, of which skin manifestations included not only mottling, cyanosis, ecchymosis, bullae and gangrene, but also amber-like change in focal areas. Besides, intermittent paling of the skin with or without deep pain sensation of the limbs over non-injection sites was observed that might be a warning sign of impending skin necrosis. Based on the literature about vasopressin-induced skin necrosis we discuss the possible role of coagulation enhancement of this molecule.
authors.affiliation: Department of Dermatology, Tri-Service General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: R Y
authors.initials: RY
authors.lastname: Lin
authors.forename: S L
authors.initials: SL
authors.lastname: Du
authors.forename: H S
authors.initials: HS
authors.lastname: Yeh
authors.forename: W M
authors.initials: WM
authors.lastname: Wang
mesh_terms: D004932:Esophageal and Gastric Varices / Q000188:drug therapy; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D014667:Vasopressins / Q000009:adverse effects*
chemical_list: D006490:Hemostatics; D014667:Vasopressins