Radioimmunoimaging of glomus tympanicum tumors by In-111 labeled monoclonal antibody using single photon emission computed tomography.
OBJECTIVE
This study aimed to evaluate the diagnostic value of radioimmunoimaging by radionuclide-labeled monoclonal antibody F023C5 (MAb), raised originally against carcinoembryonic antigen (CEA), in patients with glomus tympanicum tumors.


METHODS
Prospective.


METHODS
Preoperative imaging versus radioactivity of removed tumor.


METHODS
Two patients with paraganglioma (glomus tympanicum).


METHODS
Diagnostic.


METHODS
Radiolabeled MAb accumulates in paraganglioma tissue. Single photon emission computed tomography (SPECT) provides improved detection of lesions.


RESULTS
SPECT using F023C5 MAb detected the abnormal accumulation of radioactivity in the middle ear region. This method detected paraganglioma less than 1 cm in diameter.


CONCLUSIONS
Successful detection of glomus tympanicum in two patients using In-111-labeled F023C5 MAb is reported. The result suggests the radioimmunoimaging using this antibody is useful for the detection of not only primary glomus tumors, but also of local recurrence and unsuspected lesion in patients with paragangliomas.
Kairemo
K J
KJ
Department of Clinical Chemistry, Helsinki University Central Hospital, Finland.
Himi
T
T
Hopsu
E V
EV
Ramsay
H A
HA
D000911:Antibodies, Monoclonal; D001932:Brain Neoplasms / Q000098:blood supply / Q000175:diagnosis*; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002533:Cerebral Angiography; D004432:Ear, Middle / Q000000981:diagnostic imaging; D005682:Gadolinium; D006801:Humans; D007204:Indium; D008279:Magnetic Resonance Imaging; D010234:Paraganglia, Nonchromaffin / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D010235:Paraganglioma / Q000175:diagnosis*; D011446:Prospective Studies; D011849:Radioactive Tracers; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
D000911:Antibodies, Monoclonal; D011849:Radioactive Tracers; D007204:Indium; D005682:Gadolinium