The regulation of motor control: an evaluation of the role of dopamine receptors in the substantia nigra.
The importance of the nigrostriatal dopaminergic pathway in motor control is widely accepted and it is generally believed that the motor symptoms of Parkinson's disease result solely from reduced release of dopamine from terminals in the striatum. Over recent years there has been a growing body of evidence which suggests that dendritic dopamine release in the substantia nigra is of importance in the regulation of neuronal activity and behaviour. This evidence is reviewed together with a description of our recent findings that show nigral dopamine receptors are essential for the maintenance of normal muscle tone. It is concluded that current views of the basal ganglia circuitry involved in motor control need to be re-evaluated to take into account these recent reports. A scheme is suggested to explain how dopamine mechanisms in the substantia nigra regulate motor activity.
Crocker
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AD
Department of Clinical Pharmacology, Flinders University of South Australia, Australia.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001345:Autoradiography; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004576:Electromyography; D008297:Male; D009068:Movement / Q000187:drug effects / Q000502:physiology*; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D011804:Quinolines; D011954:Receptors, Dopamine; C000470:EEDQ; D001058:Apomorphine; D004298:Dopamine