title: Effect of dietary selenium on the response of stressed and unstressed chickens to Escherichia coli challenge and antigen.
abstract: Selenium was added to the feed of White Leghorn type chickens 1 day prior to challenge with either Escherichia coli or sheep erythrocyte antigen. The incidence of death or lesions was reduced from 86% to 21% at the optimal dose of selenium (0.4 mg/kg resulting in feed concentration of 0.45 mg/kg). After the chickens were stressed by chilling, selenium was ineffective against E. coli. Dietary additions of selenium between 0.1 and 0.8 mg/kg resulted in an antibody titer increase from 2.2 to 3.9 to the log2 against sheep erythrocytes (SRBC). Following chilling, antibody titer response was reduced from 4.9 to 2.4 to the log2. This titer reduction could be prevented with dietary additions of selenium between 0.1 and 1.2 mg/kg. The effects of a nitrofuran and selenium were additive against E. coli challenge infection.
authors.affiliation: Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.
authors.forename: C T
authors.initials: CT
authors.lastname: Larsen
authors.forename: F W
authors.initials: FW
authors.lastname: Pierson
authors.forename: W B
authors.initials: WB
authors.lastname: Gross
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000941:Antigens / Q000276:immunology; D002645:Chickens; D004032:Diet; D004198:Disease Susceptibility; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli / Q000472:pathogenicity*; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D012756:Sheep; D013312:Stress, Physiological / Q000276:immunology*
chemical_list: D000941:Antigens; D012643:Selenium