title: Acute sinusitis in the rabbit: a new rhinogenic model.
abstract: The objective of this study was to create a rhinogenic model of sinusitis using an implanted foreign body in the nasal cavity of the rabbit. The study design was a prospective controlled trial of the experimental design. In this model an obstructing foreign body was placed into the nasal cavity and then impregnated with pathogenic bacteria. This model was studied histologically using whole-mount techniques. Quantitative assessment of the degree of inflammation was made for the maxillary and ethmoid sinus and for overall effect for each animal. Bacteriologic study was performed in a limited number of animals. The results indicated that a significant infection develops in about half of animals. This peaks in intensity between 1 and 2 weeks after implantation and subsequently subsides with some evidence of long-term changes present after 4 weeks. It is concluded that this is a viable and perhaps preferable animal model to study sinusitis. Further investigation is necessary to completely characterize this model.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wayne State University, Detroit, Michigan, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Marks
mesh_terms: D000208:Acute Disease; D000818:Animals; D015521:Ethmoid Sinusitis / Q000382:microbiology / Q000473:pathology*; D005547:Foreign Bodies / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D015523:Maxillary Sinusitis / Q000382:microbiology / Q000473:pathology*; D009297:Nasal Mucosa / Q000382:microbiology / Q000473:pathology; D011817:Rabbits