Extracellular changes of taurine in the peri-infarct zone: effect of lubeluzole.
Lubeluzole is a neuroprotective compound that has been shown to stereoselectively rescue sensorimotor function and reduce infarct size in a photochemical stroke model in rats. Tissue swelling, which occurs in the peri-infarct zone, is accompanied by a compensatory taurine release. Therefore, using a microdialysis technique, we aimed at measuring changes of extracellular concentrations of taurine in the peri-infarct zone and the effects of lubeluzole and its R-isomer. Lubeluzole blocked the increase of taurine in tissue immediately surrounding a photochemically induced thrombotic neocortical infarct. By contrast, the R-isomer was completely inactive. We hypothesize that lubeluzole may reduce osmoregulatory stress in peri-infarct tissue.
Scheller
D
D
Janseen-Cilag GmbH, Drug Discovery, Neuss, Federal Republic of Germany.
de Ryck
M
M
Clincke
G
G
Tegtmeier
F
F
D000818:Animals; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D013654:Taurine / Q000378:metabolism*; D013844:Thiazoles / Q000627:therapeutic use*
D018696:Neuroprotective Agents; D010880:Piperidines; D013844:Thiazoles; D013654:Taurine; C097722:lubeluzole