title: Ileocecal segment transposition does not alter whole gut transit in humans.
abstract: OBJECTIVE
  We have recently described a reservoir for rectal replacement after total mesorectal excision for rectal carcinoma. The ileocecal segment with its intact extrinsic nerve and blood supply is placed between the ascending colon and the anal canal. This reconstruction has been shown to provide good defecation quality and anorectal function. Whether gastric emptying and small as well as large bowel transit are affected by this transposition remains unclear. Our aim was to quantify whole gut transit in such patients and compare it with that of a matched group of controls.
  
  
  METHODS
  Gastric emptying rates and small intestinal and colonic transit times were assessed scintigraphically in 12 patients aged 46 to 87 years with ileocecal reservoir reconstruction after total mesorectal excision and compared to a sex-matched group of asymptomatic healthy volunteers of similar age. Gastric emptying rates and small intestinal and colonic transit times were calculated as described previously. Data were compared using Wilcoxon's signed rank test for gastric emptying rates and small bowel transit or by analysis of variance for colonic transit; p < 0.05 was considered significant.
  
  
  RESULTS
  Gastric time for half of the meal (T50) was 161 +/- 16 minutes for patients and 201 +/- 22 for the controls. Small bowel transit time was 150 +/- 15 minutes for patients and 177 +/- 22 for the controls. Geometric center at 6 hours was 1.53 +/- 0.13 for patients and 1.27 +/- 0.16 for the controls. Geometric center at 24 hours was 2.96 +/- 0.23 for patients and 2.57 +/- 0.25 for the controls. Data are mean +/- SEM.
  
  
  CONCLUSIONS
  Gastric emptying rates and small bowel transit and colonic transit times (expressed as geometric center at 6 and 24 hours) were similar in patients with ileocecal reservoir reconstruction and in a sex- and age-matched group of healthy controls. We conclude that the transposition of an ileocecal segment with intact extrinsic neurovascular supply between the sigmoid colon and the anal canal does not alter whole gut transit, not even in any of the presumably key regions.
authors.affiliation: Division of Gastroenterology, University Hospital, Basel, Switzerland.
authors.forename: L P
authors.initials: LP
authors.lastname: Degen
authors.forename: M O
authors.initials: MO
authors.lastname: von Flüe
authors.forename: A
authors.initials: A
authors.lastname: Collet
authors.forename: C
authors.initials: C
authors.lastname: Hamel
authors.forename: C
authors.initials: C
authors.lastname: Beglinger
authors.forename: F
authors.initials: F
authors.lastname: Harder
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005746:Gastric Emptying; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D016737:Proctocolectomy, Restorative; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000601:surgery*; D012737:Sex Factors