'Ovarian-type' stroma of pancreatic mucinous cystic tumor expresses smooth muscle phenotype.
'Ovarian-type' stroma of nine mucinous cystic tumors (MCT) of the pancreas, six cystadenomas and three cystadenocarcinomas, were studied immunohistochemically. Most of the spindle cells of the 'ovarian-type' stroma were positive for smooth muscle actin and desmin, but were negative for S-100 protein, cytochrome P450 19 and CD34. Similar stroma with smooth muscle differentiation has been described in hepatobiliary MCT. Embryologic similarity between the pancreas and liver suggests a closely related origin of MCT in both organs.
Fukushima
N
N
Mukai
K
K
D000199:Actins / Q000032:analysis; D000328:Adult; D003536:Cystadenocarcinoma / Q000737:chemistry / Q000473:pathology*; D003537:Cystadenoma / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology*; D012737:Sex Factors; D017154:Stromal Cells / Q000473:pathology
D000199:Actins