Experimental chronic compression on the spinal cord of the rabbit by ectopic bone formation in the ligamentum flavum with bone morphogenetic protein.
This study was conducted to induce chronic spinal cord compression myelopathy in rabbits. The L5 lumbar lamina was cut partially in 70 rabbits, and bone morphogenetic protein (BMP) was implanted on the ligamentum flavum in 35 of them. In the BMP group, new bone formed on the dorsal side of the spinal canal and flattened the spinal cord in an anteroposterior direction. No pathological changes were detected in the intramedullary tissues by light microscopic examination. In rabbits it is possible to induce compression of the cord by using BMP, although sufficient cord compression to induce myelopathy was not achieved.
Mimatsu
K
K
Department of Orthopaedic Surgery, School of Medicine, Nagoya University, Japan.
Kishi
S
S
Hashizume
Y
Y
D000818:Animals; D001846:Bone Development / Q000187:drug effects / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000302:isolation & purification / Q000633:toxicity*; D002908:Chronic Disease; D017843:Ligamentum Flavum / Q000473:pathology*; D009999:Ossification, Heterotopic / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits; D013116:Spinal Cord / Q000473:pathology; D013117:Spinal Cord Compression / Q000209:etiology / Q000473:pathology*
D019485:Bone Morphogenetic Proteins