Cardiovascular and plasma catecholamine response to static exercise in normotensive blacks and whites.
OBJECTIVE
The objectives of the present study were (1) to evaluate the pressor response to an isometric handgrip exercise in normotensive black and white males; (2) to measure plasma catecholamine levels pre- and post-exercise, as an index of sympathetic nervous system activity; and (3) to quantify the pressor response to bolus intravenous injections of phenylephrine (an alpha-specific agonist).


METHODS
Cardiovascular and catecholamine responses to an isometric handgrip exercise (3 minutes at 30% MVC) were measured in 15 normotensive blacks and whites. In another phase of the study, pressor responses to bolus injections of phenylephrine were assessed to evaluate alpha-adrenergic sensitivity.


RESULTS
The blood pressure in the blacks increased from 119/69 to 160/120 mm HG during isometric exercise, while in the whites it increased from 118/67 to 153/110 mm HG. The blacks exhibited a greater diastolic blood pressure reactivity, as evidenced by a significant race x time interaction (p < 0.05). The heart rate responses were not significantly different between the two groups. The plasma levels of norepinephrine were similar at rest, but were 25% lower in the blacks than in the whites following isometric exercise (p < 0.01). Black subjects also demonstrated an increased pressor response to intravenous injections of phenylephrine at rest (p < 0.05).


CONCLUSIONS
The enhanced vascular sensitivity to norepinephrine may have contributed to the greater exercise pressor response in the blacks.
Duey
W J
WJ
Exercise Science Unit, University of Tennessee-Knoxville, USA.
Bassett
D R
DR
Walker
A J
AJ
Torok
D J
DJ
Howley
E T
ET
Ely
D
D
Pease
M O
MO
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000328:Adult; D044383:Black People; D001794:Blood Pressure / Q000502:physiology*; D004837:Epinephrine / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D018737:Hand Strength; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D010656:Phenylephrine / Q000494:pharmacology; D012016:Reference Values; D013564:Sympathetic Nervous System / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000097:blood*; D044465:White People
D000316:Adrenergic alpha-Agonists; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D009638:Norepinephrine; D004837:Epinephrine