[Immunohistochemical localization of MUC 1 and keratin 14 in the invasive regions of malignant eyelid tumors].
The distributional patterns of MUC 1 (the mucin whose cDNA was first cloned) and Keratin 14 (K14) in the invasive regions of malignant eyelid tumors were immunohistochemically examined by comparing with other histochemical markers. The MUC 1-positive tumor cells were detected in several serial, small, invasive tumor masses in the deep subepithelial region of the low differentiated carcinoma. They were also continuously detected in the border region between accumulated lymphocytes including T cells and tumor masses of the sebaceous carcinoma. On the other hand, K14-positive tumor cells were detected in the marginal regions of large tumor masses or those with smooth edges, some of which overlapped the distribution of MUC 1-positive cells in the tissues of undifferentiated carcinoma, squamous cell carcinoma, and sebaceous carcinoma. In general, MUC 1 may be expressed in the invasive tumor cells, whereas K14 may be expressed in the marginal cells of the stable, proliferating tumor masses.
Uehara
F
F
Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan.
Ohba
N
N
Yonezawa
S
S
Sato
E
E
D018266:Adenocarcinoma, Sebaceous / Q000737:chemistry / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology; D005142:Eyelid Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053547:Keratin-14; D007633:Keratins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis*; D009077:Mucins / Q000032:analysis*; D009361:Neoplasm Invasiveness
C507540:KRT14 protein, human; D053547:Keratin-14; D018396:Mucin-1; D009077:Mucins; D007633:Keratins