title: Toxic epidermal necrolysis: an analysis of referral patterns and steroid usage.
abstract: Toxic epidermal necrolysis (TEN) is an exfoliative disorder associated with epidermal slough and systemic toxicity. As of 1986, the literature has advocated early burn center transfer and has rejected the use of steroids. We questioned whether therapy for TEN has changed to reflect these concepts. All cases of TEN referred to our tertiary burn center since 1988 were reviewed. The history was evaluated for steroid usage and timing of burn center transfer. Drug exposures, septic complications, and deaths were noted. Statistics are expressed as mean +/- SD. Fourteen cases of TEN were identified. Transfer was delayed more than 2 days in 10 (72%) instances. Mean delay was 4.4 +/- 2.7 days. Half received steroids. There were three deaths (21%). Pneumonia developed in five patients (36%), urinary tract infections developed in three (21%) patients, seven (50%) patients required intubation, and three (21%) required hemodialysis. No differences in mortality rates or infectious complications were noted in patients who received steroids or who were transferred late. Septic complications occur frequently in TEN. Delay in transfer and initiation of steroids at referring institutions are common. Early burn center referral and avoidance of steroids needs to be reiterated at the level of the referring physician.
authors.affiliation: Department of Surgery, University of Wisconsin Hospital, Madison 53792, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Engelhardt
authors.forename: M J
authors.initials: MJ
authors.lastname: Schurr
authors.forename: R B
authors.initials: RB
authors.lastname: Helgerson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002053:Burn Units; D002056:Burns / Q000150:complications* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010346:Patient Care Management / Q000592:standards; D010360:Patient Transfer / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D018805:Sepsis / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use*; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000401:mortality / Q000628:therapy
chemical_list: D013256:Steroids