title: Neuropsychological deficits in asymptomatic atrial fibrillation.
abstract: OBJECTIVE
  To assess the preclinical effects on cognitive functions of nonrheumatic atrial fibrillation (NRAF) in patients with negative history for cerebrovascular disease.
  
  
  METHODS
  The study included 37 consecutive patients with chronic (n=16, mean age 65.3+/-6.6 years) or paroxysmal (n=21, mean age 58.3+/-9.5 years) NRAF and an equal number of control subjects in sinus rhythm, who were matched for age, education and presence of hypertension. A comprehensive neuropsychological battery including tests of attention, memory, language and visuospatial skills was administered.
  
  
  RESULTS
  Patients with chronic NRAF showed significantly poorer performances in tasks exploring attention and verbal memory functions, while the paroxysmal group was significantly impaired in a long-term memory task. The neuropsychological findings were confirmed excluding from both groups patients with CT evidence of cerebrovascular damage. A small subgroup of patients was also submitted to cerebral MRI.
  
  
  CONCLUSIONS
  Neurologically asymptomatic NRAF is related to a subclinical but significant impairment in attention and memory. These deficits could be produced by minor ischemic lesions due to microembolization, or by diffuse hypoxic damage due to hypoperfusion.
authors.affiliation: S. Maria Nascente Medical Research Center, Don Carlo Gnocchi Foundation, University of Milan, Milano, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Farina
authors.forename: E
authors.initials: E
authors.lastname: Magni
authors.forename: F
authors.initials: F
authors.lastname: Ambrosini
authors.forename: R
authors.initials: R
authors.lastname: Manfredini
authors.forename: A
authors.initials: A
authors.lastname: Binda
authors.forename: C
authors.initials: C
authors.lastname: Sina
authors.forename: C
authors.initials: C
authors.lastname: Mariani
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000523:psychology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000523:psychology; D002545:Brain Ischemia / Q000175:diagnosis / Q000523:psychology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000175:diagnosis / Q000523:psychology; D002542:Intracranial Embolism and Thrombosis / Q000175:diagnosis / Q000523:psychology; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000523:psychology; D009483:Neuropsychological Tests; D012307:Risk Factors; D013614:Tachycardia, Paroxysmal / Q000175:diagnosis* / Q000523:psychology