title: Parapapillary chorioretinal atrophy in patients with ocular hypertension. I. An evaluation as a predictive factor for the development of glaucomatous damage.
abstract: OBJECTIVE
  To determine whether parapapillary chorioretinal atrophy is a risk factor for the development of glaucomatous optic disc or visual field damage.
  
  
  METHODS
  The initial morphometric parameters of the optic disc and parapapillary atrophy were retrospectively investigated in 350 eyes of 175 patients with ocular hypertension. The prognostic value of parapapillary atrophy at the baseline examination and its relationship with known risk factors for the development of glaucomatous damage were analyzed by multivariate analysis.
  
  
  RESULTS
  Visual field loss, optic disc damage, or both were detected in 98 eyes of 53 patients during the follow-up period of at least 10 years. By univariate analysis, the presence of parapapillary atrophy, as well as higher parapapillary atrophy area-disc area, zone beta area-disc area, and parapapillary atrophy length-disc circumference ratios, at the baseline examination was associated with the conversion to glaucoma. In addition, higher intraocular pressure, larger vertical cup-disc ratio, and smaller neural rim area-disc area ratio at the baseline examination were associated with subsequent glaucomatous optic nerve damage. In a multivariate regression model adjusted for other factors, intraocular pressure (relative risk, 1.19), neural rim area-disc area ratio (relative risk, 0.72), and zone beta area-disc area ratio (relative risk, 1.32) were found to be associated with the development of optic disc damage, visual field damage, or both.
  
  
  CONCLUSIONS
  The presence and the size of parapapillary atrophy are related to the development of subsequent optic disc or visual field damage in patients with ocular hypertension.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Mo 63110, USA.
authors.forename: G
authors.initials: G
authors.lastname: Tezel
authors.forename: A E
authors.initials: AE
authors.lastname: Kolker
authors.forename: M A
authors.initials: MA
authors.lastname: Kass
authors.forename: M B
authors.initials: MB
authors.lastname: Wax
authors.forename: M
authors.initials: M
authors.lastname: Gordon
authors.forename: K D
authors.initials: KD
authors.lastname: Siegmund
mesh_terms: D002829:Choroid / Q000473:pathology*; D005260:Female; D005901:Glaucoma / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009798:Ocular Hypertension / Q000150:complications*; D009896:Optic Atrophy / Q000150:complications* / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D011379:Prognosis; D012160:Retina / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D014786:Vision Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D014794:Visual Fields / Q000502:physiology