[A vitamin-antioxidant diet decreases the level of chromosomal damages and the frequency of gene mutations in irradiated mice].
Two different methods were used to study the effect of the antioxidant vitamins mixture (AVM) containing beta-carotene, alpha-tocopherol, ascorbic acid, rutin, and microelements zinc and selenium on mouse resistance to acute and chronic irradiation. Micronucleus test demonstrated that a daily dietary supplement of AVM reliably decreased the rate of chromosomal damage, namely, X-ray-induced micronuclei in the bone marrow polychromatophilic erythrocytes of aging mice, but did not induce micronuclei formation in the young mice. Assay for somatic mutations in the hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus showed that AVM significantly decreased the rate of genic mutations in mouse splenocytes after chronic irradiation.
Fomenko
L A
LA
Bezlepkina
T A
TA
Anoshkin
A N
AN
Gaziev
A I
AI
D000375:Aging / Q000235:genetics / Q000528:radiation effects; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002869:Chromosome Aberrations; D004032:Diet / Q000379:methods*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D014131:Trace Elements / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage*
D000975:Antioxidants; D011837:Radiation-Protective Agents; D014131:Trace Elements; D014815:Vitamins