[Comparative studies of airway deposition of 99mTc-DTPA aerosol particles among 4 different nebulizers by pulmonary scintillation method].
The inhalation therapy is one of the important treatment of bronchial asthma. The effectiveness of the therapy, however, is different depending on the size of particles produced by each inhalation equipment. Therefore, we have tried to clarify the relationship between the size of inhaled particles and the deposition rate in the lung by using different types of equipment. Four different equipments, Nishou, Pari-Boy, Pari-Master and Atom Soniclizer 905 were used. 99mTc-DTPA was dissolved in physiological saline and was inhaled for evaluation of "deposition" rate in the lung. The deposition rates by Nishou, Pari-Boy, Pari-Master and Atom Soniclizer 905 were 10.4 +/- 5.8%, 27.5 +/- 14.5%, 28.5 +/- 6.5%, and 31.1 +/- 6.8%, respectively. Most of 99mTc-DTPA inhaled was observed in oral cavity. The deposition in the lung by Nishou was significantly reduced compared to other three nebulizers. Those three were evaluated as appropriate equipments for the treatment. The average size of particles in an airsol by those three equipments was less than 5 microns. The study suggests that the size of "particles" in an airsol is very important factor for the inhalation therapy.
Yamaguchi
H
H
Department of Pediatrics, Saitama Medical School.
Shiigai
N
N
Mitsubayashi
K
K
Oosika
E
E
Okada
F
F
Mitsubayashi
T
T
Sasaki
N
N
Iseya
O
O
Miyamae
T
T
Suzuki
I
I
Akasaka
T
T
D000328:Adult; D000336:Aerosols; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers / Q000592:standards*; D010316:Particle Size; D011877:Radionuclide Imaging; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics*
D000336:Aerosols; D016284:Technetium Tc 99m Pentetate