[Do mitochondria play a role in aging?].
Ageing is an unavoidable and complex phenomenon which may be a price to pay to evolution. Thus genetics appear to play a predominant role besides environmental factors. Energetic metabolism slowly declines with ageing supporting a possible active role of mitochondria, the power supply of the cells, to this process. Mitochondrial DNA alterations appear during the mid-life and in degenerative diseases such as in Parkinson's and Alzheimer's; they include large scale deletions and point mutations. Since the respiratory chain plays a major role in the generation of superoxide anions which are converted into hydroxyl radicals that may impair lipids, proteins and DNA function in mitochondria, this vicious cycle may result from both an altered control of mitochondrial biogenesis dependent from the nucleus, and/or from a lack of repair and accumulation of somatic mitochondrial DNA mutations.
Lestienne
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Unité 298 INSERM, CHU d'Angers.
D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D005544:Forecasting; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism
D004272:DNA, Mitochondrial; D005609:Free Radicals