title: Effects of catechols on free radical formation by chemotherapeutic agents (adriamycin, farmorubicin, and mitomycin).
abstract: The aim of the present study was to investigate the effects of biologically important catechols on the cytotoxicity of adriamycin, farmorubicin, and mitomycin C with respect to hydroxyl radical production. Catecholamines (adrenalin, noradrenaline, dopamine) and DOPA enhance the generation of hydroxyl radicals by chemotherapeutic antibiotics. Measures were done using a deoxyribose assay, in presence of the Co(II) + H2O2 system. Catalase and hydroxyl radical scavengers (mannitol, thiourea, cysteine, glutathione, L-lactic dehydrogenase) inhibited the deoxyribose damage caused by the drugs.
authors.affiliation: Department of Phytopharmacy and Ecotoxicology, University of Avignon, Versailles, France.
authors.forename: M
authors.initials: M
authors.lastname: Bounias
authors.forename: J
authors.initials: J
authors.lastname: Kladny
authors.forename: I
authors.initials: I
authors.lastname: Kruk
authors.forename: T
authors.initials: T
authors.lastname: Michalska
authors.forename: K
authors.initials: K
authors.lastname: Lichszteld
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology; D002395:Catecholamines / Q000737:chemistry*; D003855:Deoxyribose / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry* / Q000494:pharmacology; D015251:Epirubicin / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry*; D016685:Mitomycin / Q000737:chemistry* / Q000494:pharmacology; D016877:Oxidants
chemical_list: D000903:Antibiotics, Antineoplastic; D002395:Catecholamines; D016877:Oxidants; D017665:Hydroxyl Radical; D015251:Epirubicin; D016685:Mitomycin; D003855:Deoxyribose; D004317:Doxorubicin