Primary non-Hodgkin's lymphoma of the lacrimal sac: a case report and a review of the literature.
BACKGROUND
Primary non-Hodgkin's lymphoma of the lacrimal sac is extremely rare, with most reported cases representing secondary involvement of a systemic malignancy.


METHODS
The clinical record of a 70-year-old female who presented with epiphora and swelling of the lacrimal sac area is described. A review of the literature of patients with primary lacrimal sac lymphoma also is presented.


RESULTS
Computed tomography demonstrated a lacrimal sac mass involving the nasolacrimal canal. Histopathologic examination of a biopsy specimen revealed a diffuse large cell lymphoma. Using immunohistologic staining, the tumor was a B-cell type, similar to those described in the literature. The patient was treated with 50 gray of irradiation and chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone. The patient remained free of lymphoma 26 months after initial treatment. An ocular examination was unremarkable except for epiphora.


CONCLUSIONS
Radiotherapy and/or chemotherapy can treat localized lymphoma of the lacrimal sac successfully.
Nakamura
K
K
Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Uehara
S
S
Omagari
J
J
Kunitake
N
N
Kimura
M
M
Makino
Y
Y
Ishigami
K
K
Masuda
K
K
D000368:Aged; D005134:Eye Neoplasms / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D007765:Lacrimal Apparatus / Q000000981:diagnostic imaging / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000628:therapy; D011859:Radiography