Nocardicyclins A and B: new anthracycline antibiotics produced by Nocardia pseudobrasiliensis.
Nocardicyclins A (1) and B (2), new anthracycline antibiotics have been isolated from the mycelial cake of Nocardia pseudobrasiliensis IFM 0624 (JCM 9894). The molecular formulae of 1 and 2 have been determined as C30H35NO11 and C32H37NO12, respectively, and the structures were characterized by 1- and 8-methoxyl groups, a 10-carbonyl group and a novel carbon-methylated aminosugar constituent. Nocardicyclin A (1) exerts cytotoxic activity against L1210 and P388 leukemia. Nocardicyclins A (1) and B (2) are active against Gram-positive bacteria including Mycobacterium spp. and Nocardia spp., but inactive against Gram-negative bacteria.
Tanaka
Y
Y
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Gräfe
U
U
Yazawa
K
K
Mikami
Y
Y
Ritzau
M
M
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009615:Nocardia / Q000737:chemistry / Q000378:metabolism*
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C109702:nocardicyclin A; C109703:nocardicyclin B