Inactivation of human viruses by povidone-iodine in comparison with other antiseptics.
Inactivation of a range of viruses, such as adeno-, mumps, rota-, polio- (types 1 and 3), coxsackie-, rhino-, herpes simplex, rubella, measles, influenza and human immunodeficiency viruses, by povidone-iodine (PVP-I) and other commercially available antiseptics in Japan was studied in accordance with the standardized protocol in vitro. In these experiments, antiseptics such as PVP-I solution, PVP-I gargle, PVP-I cream, chlorhexidine gluconate, alkyldiaminoethyl-glycine hydrochloride, benzalkonium chloride (BAC) and benzethonium chloride (BEC) were used. PVP-I was effective against all the virus species tested. PVP-I drug products, which were examined in these experiments, inactivated all the viruses within a short period of time. Rubella, measles, mumps viruses and HIV were sensitive to all of the antiseptics, and rotavirus was inactivated by BAC and BEC, while adeno-, polio- and rhinoviruses did not respond to the other antiseptics. PVP-I had a wider virucidal spectrum, covering both enveloped and nonenveloped viruses, than the other commercially available antiseptics.
Kawana
R
R
Morioka Yuuai General Hospital, Japan.
Kitamura
T
T
Nakagomi
O
O
Matsumoto
I
I
Arita
M
M
Yoshihara
N
N
Yanagi
K
K
Yamada
A
A
Morita
O
O
Yoshida
Y
Y
Furuya
Y
Y
Chiba
S
S
D000256:Adenoviridae / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology*; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000008:administration & dosage / Q000494:pharmacology; D001558:Benzethonium / Q000008:administration & dosage / Q000494:pharmacology; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D004267:DNA Viruses / Q000187:drug effects*; D004770:Enterovirus / Q000187:drug effects; D005998:Glycine / Q000008:administration & dosage / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D006801:Humans; D007466:Iodophors / Q000008:administration & dosage / Q000494:pharmacology*; D008459:Measles virus / Q000187:drug effects; D009067:Mouthwashes; D009109:Mumps virus / Q000187:drug effects; D009824:Ointments; D009975:Orthomyxoviridae / Q000187:drug effects; D017955:Poliovirus / Q000187:drug effects; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000494:pharmacology*; D012328:RNA Viruses / Q000187:drug effects*; D012229:Rhinovirus / Q000187:drug effects; D012401:Rotavirus / Q000187:drug effects; D012412:Rubella virus / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D000998:Antiviral Agents; D001548:Benzalkonium Compounds; D007466:Iodophors; D009067:Mouthwashes; D009824:Ointments; D001558:Benzethonium; D011206:Povidone-Iodine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine; D005998:Glycine