Diltiazem and pentoxifylline determination in postmortem specimens.
A 78-year-old woman was found dead in her basement. Qualitative screening of available postmortem specimens detected the presence of diltiazem and pentoxifylline. Quantitations were carried out by gas chromatography using nitrogen-phosphorus detection and confirmed by gas chromatography-mass spectrometry with the following results: blood, 0.59 mg/dL diltiazem and 0.63 mg/dL pentoxifylline; urine, 1.17 mg/dL diltiazem and 0.08 mg/dL pentoxifylline; bile, 0.40 mg/dL diltiazem and 0.22 mg/dL pentoxifylline; gastric contents, 0.28 mg/dL diltiazem and 0.02 mg/dL pentoxifylline. Both drugs were found qualitatively in formaline-fixed tissues.
Engelhart
D A
DA
Cuyahoga County Coroner's Office, Cleveland, Ohio 44106, USA.
Lavins
E S
ES
Seligman
S S
SS
Sutheimer
C A
CA
D000368:Aged; D001646:Bile / Q000737:chemistry; D002121:Calcium Channel Blockers / Q000032:analysis* / Q000097:blood / Q000652:urine; D004110:Diltiazem / Q000032:analysis* / Q000097:blood / Q000652:urine; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D008099:Liver / Q000737:chemistry; D010431:Pentoxifylline / Q000032:analysis*; D014018:Tissue Distribution; D014665:Vasodilator Agents / Q000032:analysis*; D014822:Vitreous Body / Q000737:chemistry
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D004110:Diltiazem; D010431:Pentoxifylline