Has radiotherapy become too expensive to be considered a treatment option for early glottic cancer?
BACKGROUND
External beam radiotherapy and surgery produce equivalent long-term survival and tumor control in early glottic cancer. The expense and cost of radiotherapy have been challenged.


METHODS
A retrospective review was performed for 57 patients undergoing radiotherapy for glottic cancer. End points included local tumor control, relapse-free survival, cause-specific survival, medical charges, and costs. The results were compared with those of 265 patients who underwent transoral endoscopic removal or an open laryngeal procedure at the same institution.


RESULTS
The local control, larynx preservation, re-treatment, voice quality, relapse-free survival, and cancer death results and medical charges and costs are reported by treatment.


CONCLUSIONS
Radiotherapy provides at least equivalent, if not superior, local tumor control, larynx preservation, voice quality, and survival, compared with the surgical options. Overall medical charges and costs for radiotherapy are similar to transoral endoscopic resection and less than partial vertical laryngectomy.
Foote
R L
RL
Division of Radiation Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Buskirk
S J
SJ
Grado
G L
GL
Bonner
J A
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000191:economics* / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D003365:Costs and Cost Analysis; D005249:Fees and Charges; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000191:economics* / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000191:economics; D012189:Retrospective Studies; D016896:Treatment Outcome; D014831:Voice