title: Knowledge of perfusion and contractile reserve improves the predictive value of recovery of regional myocardial function postrevascularization: a study using the combination of myocardial contrast echocardiography and dobutamine echocardiography.
abstract: BACKGROUND
  This study was designed to determine the value of myocardial contrast echocardiography (MCE) and dobutamine echocardiography (DE), alone or in combination, in predicting functional recovery in patients with resting wall motion abnormalities due to CAD. MCE and DE have been independently shown to be useful in detecting myocardial viability in the post-myocardial infarction setting.
  
  
  RESULTS
  Thirty-nine patients with significant coronary artery disease and resting wall motion abnormalities underwent DE (2.5 to 20 microg x kg(-1) x min(-1)) and wall motion analysis (16-segment model). MCE was performed with selective intracoronary injections of sonicated meglumine (2 cm3). Myocardial viability was defined as presence of contrast effect by MCE and contractile reserve or an ischemic response by DE. Functional recovery (improvement in wall motion) was assessed after revascularization (percutaneous transluminal coronary angioplasty, n=20; coronary artery bypass surgery, n=19). When the two groups of patients were analyzed, MCE was associated with excellent sensitivities (84%) yet poor specificities (19% to 26%); DE had lower sensitivities (79% to 80%) but also poor specificities (30% to 36%). The combination of both was associated with excellent sensitivities (90% to 93%) and modest specificities (48% to 50%) for predicting functional recovery. A biphasic response with DE was infrequent (14% to 42%) but highly specific of functional recovery (84% to 94%). MCE had an excellent negative predictive value for functional recovery (83%).
  
  
  CONCLUSIONS
  The prediction of functional recovery post-revascularization can be enhanced by combining MCE and DE.
authors.affiliation: Department of Internal Medicine, Ochsner Medical Institutions, New Orleans, La, USA.
authors.forename: M F
authors.initials: MF
authors.lastname: Meza
authors.forename: S
authors.initials: S
authors.lastname: Ramee
authors.forename: T
authors.initials: T
authors.lastname: Collins
authors.forename: D
authors.initials: D
authors.lastname: Stapleton
authors.forename: R V
authors.initials: RV
authors.lastname: Milani
authors.forename: J P
authors.initials: JP
authors.lastname: Murgo
authors.forename: J
authors.initials: J
authors.lastname: Cheirif
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D003287:Contrast Media; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000502:physiology*; D004280:Dobutamine; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology; D011184:Postoperative Period; D011237:Predictive Value of Tests
chemical_list: D003287:Contrast Media; D004280:Dobutamine