title: The chromosomal signal for sex determination in Caenorhabditis elegans.
abstract: In Caenorhabditis elegans, sex is determined by the number of X chromosomes which, in turn, determines the expression of the X-linked gene xol-1. Recent work has shown that xol-1 expression is controlled by least two distinct regulatory mechanisms, one transcriptional and another post-transcriptional. The transcriptional regulator is a repressor acting in XX embryos; although the specific gene has not been identified, the chromosome region has been defined. A previously defined regulator of xol-1, known as fox-1, maps to a different region of the X chromosome and works post-transcriptionally, consistent with the identification of the fox-1 gene product as a putative RNA binding protein.
authors.affiliation: Department of Biology, Haverford College, PA 19041, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Meneely
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins; D004303:Dosage Compensation, Genetic; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics*; D015801:Helminth Proteins / Q000235:genetics; D008297:Male; D016601:RNA-Binding Proteins; D019849:Sex Determination Processes; D014158:Transcription, Genetic / Q000235:genetics; D014960:X Chromosome / Q000235:genetics*
chemical_list: D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D016601:RNA-Binding Proteins; C091429:XOL-1 protein, C elegans