title: Thyroid tumor as initial presentation of Hodgkin's disease: a case report including an immunophenotypic characterization.
abstract: A rare case of Hodgkin's disease which initially presented with a thyroid tumor in an 18-year-old-man is reported. The tumor involved most of the thyroid gland but was well demarcated, and the border between the tumor and the remnants of the thyroid gland was relatively clear, suggesting secondary Hodgkin's disease involving the thyroid gland. Histologic examination of the tumor revealed nodular sclerosing Hodgkin's disease composed of many peculiar osteoclast--like giant cells and a few typical Reed--Sternberg cells in the background of dominant eosinophils. With an immunophenotypic study it was shown that these giant cells were positive for the monoclonal antibodies LeuM1 and BerH2, but negative for LCA. Thus the histological diagnosis was clearly confirmed.
authors.affiliation: Third Department of Internal Medicine, Kanazawa University Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Mizukami
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Ohtake
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000293:Adolescent; D006689:Hodgkin Disease / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*; D013965:Thyroidectomy; D014057:Tomography, X-Ray Computed