Immunostimulation as adjuvant for the chemotherapy of experimental schistosomiasis.
Immunosuppressed animals respond poorly to schistosomal chemotherapy and a proper response can be restored by the administration of immune serum. Present study attempts to search whether immunological stimulation would increase drug effectiveness. Swiss mice infected with 50 S. mansoni cercariae were later treated with complete Freund's adjuvant. Treatment with oxamniquine was made with 100 mg/kg.b.w., 25 mg/kg.b.w. and 50 mg/kg.b.w., the last two doses representing a fourth and a half of the recommended curative dose. Appropriate controls for the drug, the adjuvant and the infection were also studied. The serum-level of anti-S. mansoni antibodies (ELISA) and recovery of worms by perfusion of the portal vein system were the evaluated parameters. Statistical analysis of the results failed to reveal significant differences in worm recovery between adjuvant-stimulated animals treated with oxamniquine and any of the treated controls receiving the same amount of the drug. Although total lack of immunity interferes with curative treatment the usual immune response seems to be sufficient to allow for curative drug action in schistosomiasis and thus apparently does not need to be artificially stimulated.
Silva
L M
LM
Laboratory of Experimental Pathology, Centro de Pesquisas Gonçalo Moniz, FIOCRUZ, Salvador, Bahia, Brasil.
Andrade
Z A
ZA
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005620:Freund's Adjuvant; D008297:Male; D051379:Mice; D010073:Oxamniquine / Q000494:pharmacology*; D012552:Schistosomiasis / Q000188:drug therapy* / Q000276:immunology*; D012556:Schistosomicides / Q000494:pharmacology*
D012556:Schistosomicides; D010073:Oxamniquine; D005620:Freund's Adjuvant