Studies of the mechanism of the anticonvulsant effect of delta-sleep-inducing peptide in conditions of increased oxygen tension.
Studies of the protective actions of three doses of delta-sleep-inducing peptide (DSIP) given at different times before barochamber compression of animals to an oxygen tension of 0.7 MPa showed that the optimum DSIP dose is 12 micrograms/100 g. Intraperitoneal administration of this dose of DSIP delayed the onset of generalized convulsive activity by a factor of 2-2.5 in animals exposed to an oxygen tension of 0.7 MPa and promoted normalization of the sleep-walking cycle within 24 h after exposure to hyperbaric oxygen (HBO), by creating an optimal balance between excitatory and inhibitory amino acid neuromediators.
Mendzheritskii
A M
AM
Laboratory of Neuropeptide Physiology and Biochemistry, A. B. Kogan Science Research Institute of Neurocybernetics, Rostov State University.
Lysenko
A V
AV
Uskova
N I
NI
Sametskii
E A
EA
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001273:Atmosphere Exposure Chambers; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004569:Electroencephalography; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D012640:Seizures / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D012890:Sleep / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects
D000927:Anticonvulsants; D018377:Neurotransmitter Agents; D003701:Delta Sleep-Inducing Peptide