title: The influence of long-term treatment with povidone-iodine on thyroid function.
abstract: Povidone-iodine (PVP-I) is generally very safe, but cases of thyroid dysfunction induced by PVP-I have been reported. The effect of long-term treatment with PVP-I on thyroid function was to be assessed. In 40 inpatients of the department of neurology, the status of the use of PVP-I preparations and their effects on serum inorganic iodine levels and thyroid functions were investigated. In 27 patients treated with PVP-I for a long term, inorganic iodine levels were significantly increased as compared to those in 13 patients without PVP-I treatment. Out of 27 patients treated with PVP-I in the long term, subclinical hypothroidism was seen in 3 patients, mild hyperthroidism was seen in 1 patient, and subclinical hyperthyroidism was suspected in 7 patients. Patients treated with PVP-I for a long time should be observed carefully for any manifestation of thyroid dysfunction.
authors.affiliation: Department of Neurology, National Sanatorium Minami-Okayama Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nobukuni
authors.forename: N
authors.initials: N
authors.lastname: Hayakawa
authors.forename: R
authors.initials: R
authors.lastname: Namba
authors.forename: Y
authors.initials: Y
authors.lastname: Ihara
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Takada
authors.forename: T
authors.initials: T
authors.lastname: Hayabara
authors.forename: S
authors.initials: S
authors.lastname: Kawahara
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications; D000891:Anti-Infective Agents, Local / Q000009:adverse effects / Q000627:therapeutic use*; D002405:Catheterization, Central Venous / Q000295:instrumentation; D005260:Female; D005774:Gastrostomy / Q000295:instrumentation; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced; D007037:Hypothyroidism / Q000139:chemically induced; D007455:Iodine / Q000097:blood; D007466:Iodophors / Q000009:adverse effects / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects; D010288:Parenteral Nutrition / Q000295:instrumentation; D011206:Povidone-Iodine / Q000009:adverse effects / Q000627:therapeutic use*; D012449:Safety; D012883:Skin Ulcer / Q000188:drug therapy; D013132:Spinocerebellar Degenerations / Q000150:complications; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014140:Tracheotomy; D014284:Triiodothyronine / Q000097:blood; D014521:Urethra / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D007466:Iodophors; D014284:Triiodothyronine; D011206:Povidone-Iodine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine