title: Triple extramammary Paget's disease.
abstract: BACKGROUND
  Triple extramammary Paget's disease (TEPD) has been considered to be rare in the English literature, and its incidence and characteristics are unclear. There are many therapeutic options for treating extramammary Paget's disease (EPD).
  
  
  OBJECTIVE
  Our purpose was to investigate how many TEPD cases have been reported previously and to describe their characteristics. We also describe the effectiveness of radiotherapy for them.
  
  
  METHODS
  We report two TEPD cases, and summarize previously reported TEPD cases together with our cases.
  
  
  RESULTS
  Twenty-three TEPD cases have been reported previously. Of these, 19 cases have been in Japan. All but one patient with TEPD were male. Their axillary lesions often showed no eruptions or very slight erythema. Radiotherapy for our cases was effective although the effectiveness of radiotherapy is controversial.
  
  
  CONCLUSIONS
  In genital Paget's disease bilateral axillae should be examined histologically, even if they show no or slight eruptions. Radiotherapy may be useful for EPD, particularly axillary Paget's disease.
authors.affiliation: Department of Dermatology, Nagoya City University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kitajima
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
authors.forename: R A
authors.initials: RA
authors.lastname: Schwartz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D005834:Genital Neoplasms, Male / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000528:radiation effects; D008207:Lymphatic Metastasis / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy