Antigen-independent determinants of graft survival in living-related kidney transplantation.
We used the United Network of Organ Sharing database to define the antigen independent risk factors which contributed to the survival of 8,582 kidney transplants performed in the U.S. between October 1987 and December 1991, using multivariable regression techniques. In this analysis, death with a functioning graft was censored. The risk ratio for graft loss was high when recipients were African-American or had high body surface area, or when donors were older or female. The analysis shows that antigen independent factors that are associated with lower donor kidney mass or increased recipient size play a significant role in living donor kidney transplant loss, as they do in cadaver kidney transplantation.
Chertow
G M
GM
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Brenner
B M
BM
Mori
M
M
MacKenzie
H S
HS
Milford
E L
EL
D000293:Adolescent; D000328:Adult; D000375:Aging; D001830:Body Surface Area; D002648:Child; D015331:Cohort Studies; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D014019:Tissue Donors
D006680:HLA Antigens