Primary biliary cirrhosis associated with antiphospholipid syndrome.
A 47-year-old female was admitted for severe pain of 1 month's duration in the third and fourth toes of the right foot, culminating in gangrene. Laboratory findings revealed liver enzyme abnormalities, and anti-mitochondrial, anti-phospholipid and antinuclear and doubtful anti-DNA antibodies. Systemic lupus erythematosus (SLE) was excluded on clinical grounds after a 6-year follow-up. Therefore, a diagnosis was made of the primary antiphospholipid syndrome, complicated by microvasculopathy, and associated with primary biliary cirrhosis.
Hoffman
M
M
Department of Medicine A, Sourasky Medical Center, Tel Aviv University, Israel.
Burke
M
M
Fried
M
M
Turner
D
D
Yosipov
Y
Y
Yust
I
I
D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology; D001706:Biopsy; D005260:Female; D005734:Gangrene; D006801:Humans; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000209:etiology*; D014034:Toes / Q000098:blood supply / Q000473:pathology*