title: Alcohol dependence: a critical look at the effects of alcohol metabolism.
abstract: This paper explores the metabolic consequences of alcohol misuse and identifies the pathophysiological reasons why alcohol, no matter what quantity is taken regularly, is not beneficial for the normal functioning of most body systems. Although moderate ethanol consumption may reduce stress and the risk of coronary heart disease, ethanol also exerts a direct toxicological effect because it interferes with hepatic metabolism and immune functions. Liver transplantation may be necessary for end-stage liver disease in alcoholics. A causal effect between alcohol intake and several cancers has been reported. Both environmental and genetic factors are involved in the susceptibility to alcoholism. An explanation of alcohol dependence as a family disease is introduced to shed light on the magnitude of its collateral effects on the family and on the community as a whole. The adverse effects of alcohol on pregnant women and the fetus are also discussed. To provide awareness of the effectiveness of community efforts, we examined the possible intervention strategies and the role of community care in this regard.
authors.affiliation: Faculty of Education, University of Central England, Edgbaston, Birmingham, U.K.
authors.forename: E
authors.initials: E
authors.lastname: Anyanwu
authors.forename: N
authors.initials: N
authors.lastname: Watson
mesh_terms: D000328:Adult; D000368:Aged; D000425:Alcohol Amnestic Disorder / Q000209:etiology; D000437:Alcoholism / Q000150:complications / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D018450:Disease Progression; D000431:Ethanol / Q000009:adverse effects* / Q000378:metabolism / Q000494:pharmacology; D005192:Family Health; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011247:Pregnancy
chemical_list: D000431:Ethanol