title: In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae.
abstract: The purpose of this study was to compare the in vitro activity of a new ketolide, HMR 3004 (RU64004), to that of three macrolides and one azalide against 608 Streptococcus pneumoniae and 202 Haemophilus influenzae. Macrolide-resistant pneumococci were susceptible to HMR 3004, even if they were resistant to clindamycin. Against Haemophilus influenzae, HMR 3004 and azithromycin were nearly identical in potency; the macrolides were 8- to 16-fold less active. HMR 3004 may be useful for treating respiratory tract infections if sufficient concentrations can be achieved at the local sites of infection.
authors.affiliation: Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Barry
authors.forename: P C
authors.initials: PC
authors.lastname: Fuchs
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
mesh_terms: D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000378:metabolism; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D015575:Roxithromycin / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000378:metabolism; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C105420:RU 64004; C053853:dirithromycin; D015575:Roxithromycin; D002981:Clindamycin; D004917:Erythromycin; D017963:Azithromycin; D001618:beta-Lactamases; D017291:Clarithromycin