title: Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-beta-D-glucopyranoside and related compounds.
abstract: Resveratrol 3-O-beta-D-glucopyranoside (1) has been isolated from the seeds of Erythrophleum lasianthum (Caesalpinioidae, Leguminosae), a South African plant used in traditional medicine, and has shown antiplatelet aggregation activity. The synthesis of 1, related hydroxystilbenes, and their glucosides has been undertaken to provide larger quantities, for further biological evaluation, and has been accomplished via Wittig reactions followed by glucosylation under phase transfer catalysis.
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Università degli Studi, Milano, Italy. sellogui@imicilea.cilea.it
authors.forename: F
authors.initials: F
authors.lastname: Orsini
authors.forename: F
authors.initials: F
authors.lastname: Pelizzoni
authors.forename: L
authors.initials: L
authors.lastname: Verotta
authors.forename: T
authors.initials: T
authors.lastname: Aburjai
authors.forename: C B
authors.initials: CB
authors.lastname: Rogers
mesh_terms: D005960:Glucosides / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D013267:Stilbenes
chemical_list: D005960:Glucosides; D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; C109945:resveratrol 3-O-glucopyranoside