Diabetic complications and the genetics of signal transduction. A study of retinopathy in NIDDM.
Cytosolic low molecular weight acid phosphatase (ACP1) is a high polymorphic phosphotyrosine-protein-phosphatase involved in signal transduction. In NIDDM subjects we have found that ACP1 genotype is a highly significant predictor of retinopathy, suggesting that genetic variability of signal transduction may have an important role in the susceptibility to this complication. Adenosine deaminase, ABO blood groups and several clinical variables have been also considered. The results point out the importance of interactions between genetic systems. Among non-genetic variables dislipidemia and treatment with insulin are significantly associated with retinopathy.
Lucarini
N
N
Department of MCA Biology, University of Camerino School of Science, Italy.
Bottini
N
N
Antonacci
E
E
Borgiani
P
P
Faggioni
G
G
Gloria-Bottini
F
F
D000135:Acid Phosphatase / Q000235:genetics; D000243:Adenosine Deaminase / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D015398:Signal Transduction / Q000235:genetics*
D000135:Acid Phosphatase; D000243:Adenosine Deaminase