title: Functional evaluation of the remaining kidney in kidney donors by radionuclide dynamic imaging using a graphic method with factor analysis.
abstract: An uptake coefficient proportional to the glomerular filtration rate (GFR) can be estimated from dynamic renal images with 99Tcm-DTPA using Rutland's graphic method. We have developed a new method of extracting the input and retention functions by applying factor analysis to the renal dynamic images obtained with 99Tcm-DTPA, which we have called the 'factor uptake coefficient' (Factor UC). In the present study, we followed 13 living kidney donors (7 males, 6 females) by measuring the Factor UC in each kidney before nephrectomy and in the remaining kidney 3 weeks and 1 year after nephrectomy. The median Factor UC in the remaining kidney increased from a pre-nephrectomy value of 0.31 to 0.52 three weeks post-nephrectomy, which then remained unchanged for up to 1 year. These results indicate that functional compensation occurs following unilateral nephrectomy, and that this process is complete within 3 weeks after nephrectomy.
authors.affiliation: Department of Transplantation, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kakuta
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Hida
authors.forename: M
authors.initials: M
authors.lastname: Wakabayasi
authors.forename: T
authors.initials: T
authors.lastname: Fujisaki
authors.forename: M
authors.initials: M
authors.lastname: Kitamura
authors.forename: S
authors.initials: S
authors.lastname: Hiraga
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000652:urine; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000502:physiology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011857:Radiographic Image Interpretation, Computer-Assisted; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate; D014019:Tissue Donors
chemical_list: D019275:Radiopharmaceuticals; D003404:Creatinine; D016284:Technetium Tc 99m Pentetate