Long-acting gonadotropin-releasing hormone agonists in the differential diagnosis of male precocious puberty.
Male sexual precocity is defined as the development of secondary sexual characteristics before 9 years of age. It can be classified as gonadotropin-dependent precocious puberty (GnDP) or gonadotropin-independent precocious puberty (GnIP) and sometimes the differential diagnosis between these entities is difficult. To determine whether long-acting GnRH agonists (GnRH-a) are effective in differential diagnosis of male precocious puberty, we measured gonadotropins and testosterone levels 30 days after a single administration of depot GnRH-a (triptorelin, gosereline or leuprolide) in 10 boys with sexual precocity of different etiologies. Testosterone levels 30 days after depot GnRH-a were in the prepubertal range in patients with GnDP but not in GnIP. We conclude that measurement of testosterone levels 30 days after long-acting GnRH-a is effective in the differential diagnosis of male sexual precocity.
Albano
M C
MC
Developmental Endocrinology Unit, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Brazil.
Latronico
A C
AC
Arnhold
I J
IJ
Domenice
S
S
Bloise
W
W
Mendonca
B B
BB
D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D017273:Goserelin; D006801:Humans; D007223:Infant; D016729:Leuprolide; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000209:etiology; D013739:Testosterone / Q000097:blood; D017329:Triptorelin Pamoate
D017329:Triptorelin Pamoate; D017273:Goserelin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide