title: Monitoring of serologic immune parameters in inflammatory skin diseases.
abstract: This paper deals with the correlation of clinical scoring and serologic markers of inflammation in atopic dermatitis and psoriasis. Serum eosinophil cationic protein (ECP), soluble interleukin-2 receptor (sIL-2R), total serum IgE, IgG and IgM anti-IgE antibodies, and IgE immune complexes were evaluated in monitoring inflammatory skin diseases such as atopic dermatitis and psoriasis. Well-established clinical activity scores were used as standards in recording skin improvement under treatment in a clinical setting. Serum ECP was found to be increased in both atopic dermatitis and psoriasis patients compared to normal controls; sIL-2R and IgE immune complexes were increased only in atopics with increased serum IgE. Anti-IgE antibodies did not show any deviation in both groups of patients. There was a significant elevation of sIL-2R and IgE immune complexes and a nonsignificant elevation of ECP in high-IgE atopics in comparison to those with normal serum IgE. In both groups of patients, there was a significant reduction of ECP and sIL-2R accompanying the improving skin condition. Serum IgE and the other immune parameters failed to respond. In contrast to other studies, serum ECP failed to correspond significantly with disease activity in our study. Our results showed measurable changes of ECP and sIL-2R for atopic dermatitis and/or psoriasis under treatment, but comparison to clinical scores remains difficult due to the different basis of the two systems. The only significant correlation was established for relative changes in sIL-2R and psoriasis area and intensity (PASI), a correlation which might be a useful approach in psoriasis.
authors.affiliation: University Hospital Department of Dermatology, Jena, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Gebhardt
authors.forename: H C
authors.initials: HC
authors.lastname: Wenzel
authors.forename: U C
authors.initials: UC
authors.lastname: Hipler
authors.forename: D
authors.initials: D
authors.lastname: Herrmann
authors.forename: U
authors.initials: U
authors.lastname: Wollina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D000936:Antigen-Antibody Complex / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003872:Dermatitis / Q000097:blood*; D003876:Dermatitis, Atopic / Q000097:blood / Q000145:classification; D047091:Eosinophil Granule Proteins; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000145:classification; D015375:Receptors, Interleukin-2 / Q000097:blood; D012260:Ribonucleases
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D018836:Inflammation Mediators; D015375:Receptors, Interleukin-2; C026408:anti-IgE antibodies; D007073:Immunoglobulin E; D012260:Ribonucleases