title: Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women.
abstract: To investigate the effect of estrogen with antioxidant potential on soluble markers of chronic vascular inflammation, we administered either transdermal 17beta-estradiol 0.1 mg/day (9 women) or 17beta-estradiol 0.1 mg and medroxyprogesterone acetate 2.5 mg/day (11 women) for 1-month treatment in a randomized design, with measurement of cell adhesion molecules. Hormone therapy significantly lowered intercellular adhesion molecules-1 levels by 8% (p = 0.009) and tended to lower E-selectin levels (by 6%, p = 0.096), and VCAM-1 levels (by 4%, p = 0.084).
authors.affiliation: Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1650, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Koh
authors.forename: M N
authors.initials: MN
authors.lastname: Bui
authors.forename: R
authors.initials: R
authors.lastname: Mincemoyer
authors.forename: R O
authors.initials: RO
authors.lastname: Cannon
mesh_terms: D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D019040:E-Selectin / Q000097:blood / Q000187:drug effects; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000187:drug effects*; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood* / Q000187:drug effects; D016896:Treatment Outcome; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood / Q000187:drug effects*
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D004967:Estrogens; D008074:Lipoproteins; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1