Donor sepsis is not a contraindication to cadaveric organ donation.
Systemic donor infection is regarded as being an absolute contraindication to cadaveric organ donation for transplantation. This is largely due to fear of transmitting pathogenic organisms to the immunosuppressed recipient. However, due to the current shortage of organs available for transplantation, clinicians are faced with the option of using organs from 'non-ideal' donors, such as those patients with documented evidence of infection. We report the successful outcome of six orthotopic liver transplants, 11 renal transplants, one combined heart lung transplant and one simultaneous kidney and pancreas transplant with organs from eight donors in whom bacterial meningitis (n = 7) and acute bacterial epiglottitis (n = 1) were the antecedent causes of death.
Little
D M
DM
Department of Urology and Transplantation, Beaumont Hospital, Dublin, Ireland.
Farrell
J G
JG
Cunningham
P M
PM
Hickey
D P
DP
D002102:Cadaver; D000075202:Contraindications; D004826:Epiglottitis; D005500:Follow-Up Studies; D006085:Graft Survival; D016041:Heart-Lung Transplantation; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D016920:Meningitis, Bacterial; D016377:Organ Transplantation / Q000379:methods; D016035:Pancreas Transplantation; D014019:Tissue Donors; D009927:Tissue and Organ Procurement