Zopiclone versus diazepam effects on EEG power maps in healthy volunteers.
EEG effects of zopiclone (7.5 mg), a cyclopyrrolone derivative with hypnotic action, were compared with effects of diazepam (10 mg). Multichannel EEG recordings, double-blind crossover trials with placebo, and oral single doses were used in healthy volunteers. Vigilance-controlled EEG before and after zopiclone (and placebo), and before and after diazepam (and placebo) were analyzed into FFT power spectra. Effects were assessed as placebo-referred pre-post-medication power differences in four frequency bands. Overall statistics showed significant (P < 0.007) global differences between medication effects in the delta frequency band (0.5-3.5 Hz). After zopiclone, fronto-central delta increased bilaterally, whereas after diazepam delta decreased over centro-parietal to right temporo-occipital regions. These spatially different brain electric effects show that different neuronal populations must have become active in response to zopiclone and diazepam.
Yamadera
H
H
Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan.
Kato
M
M
Tsukahara
Y
Y
Brandeis
D
D
Okuma
T
T
D000328:Adult; D053961:Azabicyclo Compounds; D001931:Brain Mapping; D018592:Cross-Over Studies; D003975:Diazepam / Q000008:administration & dosage*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D010879:Piperazines / Q000008:administration & dosage*
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone; D003975:Diazepam