Continuing on J.P. Henry's path; studies of physiology and pathophysiology of cardiopulmonary receptors in humans.
The seminal work of Henry and Gauer lead us to a) show that in healthy humans cardiopulmonary receptors (CPR) regulate renin release, b) that low renin hypertension is associated with an expanded cardiopulmonary volume. This suggested that the low renin state in hypertension may be due to excessive inhibition of renin by the CPR. In the course of these experiments we uncovered an undescribed pressor reflex which was used to investigate the effect of intermittent pressor episodes on cardiac structure in dogs. Finally, in recent years, we used unloading of CPR to show that reflex vasoconstriction causes acute insulin resistance in the human forearm.
Julius
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S
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA.
Valentini
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M
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D004285:Dogs; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D011311:Pressoreceptors / Q000502:physiology*; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000503:physiopathology*