title: The effects of clomiphene citrate on normally ovulatory women.
abstract: OBJECTIVE
  To investigate the efficacy of clomiphene citrate (CC) on normally ovulatory women who complained of infertility.
  
  
  METHODS
  A randomized study.
  
  
  METHODS
  University Hospital.
  
  
  METHODS
  Thirty-three normally ovulatory women with unexplained infertility.
  
  
  METHODS
  Eighteen women received CC at a 50-mg dosage. Fifteen women received no ovulation-induction drugs.
  
  
  METHODS
  The pregnancy rate (PR) per patient, the PR per cycle, and the cumulative pregnancy rate.
  
  
  RESULTS
  Seven patients in the CC group stopped taking CC, and observations were terminated because of antiestrogenic effects. The pregnancy rate (PR) per patient and the PR per cycle were significantly decreased (P < 0.005) in the CC group (4 of 18 [22.2%] and 4 of 66 [6.1%], respectively) than in the spontaneous group (11 of 15 [73.3%] and 11 of 52 [21.2%], respectively). Kaplan-Meier tests showed that the cumulative pregnancy rate in the CC group was significantly lower than in the spontaneous group (P < 0.05). Five of seven patients who had stopped taking CC became pregnant in spontaneous cycles.
  
  
  CONCLUSIONS
  Administration of CC to normally ovulatory women is not efficacious in terms of increasing the pregnancy rate.
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Aomori, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fujii
authors.forename: A
authors.initials: A
authors.lastname: Fukui
authors.forename: Y
authors.initials: Y
authors.lastname: Fukushi
authors.forename: A
authors.initials: A
authors.lastname: Kagiya
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology* / Q000627:therapeutic use; D005306:Fertilization / Q000187:drug effects*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D010060:Ovulation; D011247:Pregnancy; D017211:Treatment Failure
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene