title: [Two cases of pure akinesia with unusual activation in dorsal part of the frontal lobe during gait--surface EMG and PET study].
abstract: FDG-PET activation study was performed in two pure akinesia (PA) patients with silent pattern in surface electromyography (EMG) frozen gait analysis. Three patients (2 PA and 1 PD with reciprocal co-contraction pattern) and 7 normal subjects underwent FDG-PET study in two different condition of "rest" and "walk", in order to evaluate the change in regional cerebral activity during gait. In a PD patient, the activated pattern was no different from that of normal individuals; the cerebellar vermis was solely activated significantly. In contrast, 2 PA patients showed characteristic activation in the dorsolateral frontal area in addition to the areas found in normals. These results suggest that the dorsolateral frontal cortex may play an inhibiting role to the motor cortex resulting in the silent pattern of frozen gait in PA. Combined study of surface EMG and FDG-PET during gait may be useful for analyzing the pathophysiological mechanism of gait disturbance.
authors.affiliation: Department of Neurology, Tokyo Metropolitan Geriatric Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: M
authors.initials: M
authors.lastname: Murata
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Nagura
authors.forename: H
authors.initials: H
authors.lastname: Yamanouchi
mesh_terms: D000368:Aged; D004576:Electromyography; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005684:Gait / Q000502:physiology*; D006801:Humans; D009069:Movement Disorders / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology; D019275:Radiopharmaceuticals; D013382:Subtraction Technique; D014055:Tomography, Emission-Computed
chemical_list: D019275:Radiopharmaceuticals