[Inhibiton of endogenous synthesis of nitroso compounds by Selenium in rats].
The inhibiting effect of organic Se (selen-enriched yeast Bioselen) on the endogenous synthesis of N-nitrosubstances was investigated in the Wistar rats, receiving 15 mg of sodium nitritis and 24 mg of diethylamin per 1 kg of bodyweight during 22 days. The level of nitrosoprolin synthesis and (NPro) and the level of nitrosodiethyl (NDie) in the stomach of rats served as the main indices. The highest level of NPro and NDie were revealed in the rats, without selen supplementation (581.2 +/- 113.3 mg per kg of bodyweight and 29.8 +/- 3.0 mg per kg of bodyweight). The highest inhibiting effect of Se was 54.5% for NPro and 54.7% for NDie and it was shown for the Se concentration of 1.5 mg per 1 kg of forage. The increase of Se dosage to 3.0 mg per 1 kg of forage was less effective and resulted in 25.5% of inhibiting of NPro u 47.0% - NDie.
Khotimichenko
S A
SA
Zhukova
G F
GF
Deryagina
V P
VP
Golubkina
N A
NA
D000284:Administration, Oral; D000818:Animals; D019587:Dietary Supplements; D004048:Diethylamines / Q000037:antagonists & inhibitors; D004052:Diethylnitrosamine / Q000032:analysis / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000378:metabolism; D009153:Mutagens / Q000378:metabolism*; D009602:Nitrosamines / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D012977:Sodium Nitrite / Q000037:antagonists & inhibitors; D013270:Stomach / Q000187:drug effects
D004048:Diethylamines; D009153:Mutagens; D009602:Nitrosamines; D004052:Diethylnitrosamine; C034281:diethylamine; C010259:nitrosoproline; D012643:Selenium; D012977:Sodium Nitrite