title: Malignant eccrine spiradenoma. Case report and review of the literature.
abstract: Malignant eccrine spiradenoma is an exceedingly rare tumor. A case of a 72-year-old women with this highly aggressive malignancy arising from a long-standing lower leg lesion is reported. Management during the course of disease included surgery, radiation therapy (RT), hyperthermic limb perfusion chemotherapy, and chemotherapy. The patient died of her disease, with widespread metastatic disease 20 months after the diagnosis. A review of the literature is presented, and treatment considerations are summarized.
authors.affiliation: Department of Radiation Oncology, Saint Mary's Medical Center, San Francisco, CA 94117, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Tay
authors.forename: E M
authors.initials: EM
authors.lastname: Tapen
authors.forename: P G
authors.initials: PG
authors.lastname: Solari
mesh_terms: D006607:Adenoma, Sweat Gland / Q000473:pathology* / Q000628:therapy / Q000648:ultrastructure; D000368:Aged; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007866:Leg; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D013544:Sweat Gland Neoplasms / Q000473:pathology* / Q000628:therapy / Q000648:ultrastructure
chemical_list: D004273:DNA, Neoplasm