BE-32030 A, B, C, D and E, new antitumor substances produced by Nocardia sp. A32030.
New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer, PC-13 human lung cancer and MKN-45 human stomach cancer cell lines.
Tsukamoto
M
M
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Tsukuba, Japan.
Murooka
K
K
Nakajima
S
S
Abe
S
S
Suzuki
H
H
Hirano
K
K
Kondo
H
H
Kojiri
K
K
Suda
H
H
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001381:Azepines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009615:Nocardia / Q000737:chemistry / Q000378:metabolism*; D010080:Oxazoles / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D001381:Azepines; C109697:BE 32030A; C109698:BE 32030B; C109699:BE 32030C; C109700:BE 32030D; C109701:BE 32030E; D010080:Oxazoles