The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses.
Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive CHO cells transfected with mCAR cDNA became susceptible to infection by coxsackieviruses B3 and B4 and showed increased susceptibility to adenovirus-mediated gene transfer. These results indicate that the same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo.
Bergelson
J M
JM
Division of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. bergelson@email.chop.edu
Krithivas
A
A
Celi
L
L
Droguett
G
G
Horwitz
M S
MS
Wickham
T
T
Crowell
R L
RL
Finberg
R W
RW
D000256:Adenoviridae / Q000235:genetics / Q000472:pathogenicity*; D000595:Amino Acid Sequence; D000818:Animals; D016466:CHO Cells; D003001:Cloning, Molecular; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D006224:Cricetinae; D018076:DNA, Complementary / Q000235:genetics; D004770:Enterovirus / Q000235:genetics / Q000472:pathogenicity*; D015870:Gene Expression; D018014:Gene Transfer Techniques; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011991:Receptors, Virus / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D014018:Tissue Distribution; D014162:Transfection
C568771:CLMP protein, human; C568772:CLMP protein, mouse; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D018076:DNA, Complementary; D012333:RNA, Messenger; D011991:Receptors, Virus