title: Induction of matrix metalloproteinases following brain injury in rats.
abstract: Matrix metalloproteinases (MMPs) are important in various pathophysiological processes related with the tissue remodeling. We planned the experiments to determine whether MMPs participate in disruption and repair of the tissue following brain injury. We have studied induction of MMP-9, a 92 kilodalton (kDa) gelatinase, in traumatic brain tissue, which may be produced by brain residual cells. We speculate that MMP-9 plays a role in post-traumatic brain edema formation.
authors.affiliation: Department of Neurosurgery, Nagoya University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shibayama
authors.forename: H
authors.initials: H
authors.lastname: Kuchiwaki
authors.forename: S
authors.initials: S
authors.lastname: Inao
authors.forename: K
authors.initials: K
authors.lastname: Ichimi
authors.forename: J
authors.initials: J
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Hamaguchi
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000201:enzymology*; D017364:Collagenases / Q000096:biosynthesis*; D004591:Electrophoresis, Polyacrylamide Gel; D004790:Enzyme Induction; D008297:Male; D020780:Matrix Metalloproteinase 9; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats
chemical_list: D017364:Collagenases; D020780:Matrix Metalloproteinase 9