title: Acute Epstein-Barr virus infection complicated by severe thrombocytopenia.
abstract: We describe one patient with acute Epstein-Barr virus (EBV) infection associated with severe thrombocytopenia and review 36 additional cases reported in the literature. Complications of EBV infection due to severe thrombocytopenia occurred in 10 (27.0%) of 37 patients, and 2 (5.4%) of 37 patients died. Although acute EBV infections are generally benign and self-limiting, thrombocytopenia, a potentially serious complication, should not be overlooked.
authors.affiliation: Department of Medicine, Graduate School of Medicine, The University of Tennessee Medical Center at Knoxville, 37920-6999, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Pipp
authors.forename: N D
authors.initials: ND
authors.lastname: Means
authors.forename: J W
authors.initials: JW
authors.lastname: Sixbey
authors.forename: K L
authors.initials: KL
authors.lastname: Morris
authors.forename: C L
authors.initials: CL
authors.lastname: Gue
authors.forename: L M
authors.initials: LM
authors.lastname: Baddour
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000150:complications*; D014412:Tumor Virus Infections / Q000150:complications*