title: Intracranial and spinal metastases from a ganglioglioma with unusual cytogenetic abnormalities in a patient with complex partial seizures.
abstract: We describe an unusual clinical presentation of a ganglioglioma in a patient with complex partial seizures. The patient underwent a right temporal lobectomy with subtotal tumor resection at age 15 years, followed by a complete resection 1 year later. Follow-up MRI scan a year later documented recurrence and leptomeningeal dissemination. Another biopsy was performed. Pathological examination revealed similar histology in all three resections, with a ganglioglioma showing no evidence of anaplasia. The tumor exhibited a number of karyotypic abnormalities, notably, a paracentric inversion of chromosome 7. In summary, despite lacking anaplastic features by conventional histological criteria, this ganglioglioma showed an unsusual karyotype and demonstrated radiological evidence of widespread dissemination.
authors.affiliation: Division of Pathology, Hospital for Sick Children, University of Toronto, Ontario, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Jay
authors.forename: J
authors.initials: J
authors.lastname: Squire
authors.forename: S
authors.initials: S
authors.lastname: Blaser
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoffman
authors.forename: P
authors.initials: P
authors.lastname: Hwang
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D002869:Chromosome Aberrations / Q000235:genetics; D003131:Combined Modality Therapy; D017029:Epilepsy, Complex Partial / Q000473:pathology / Q000601:surgery*; D005500:Follow-Up Studies; D018303:Ganglioglioma / Q000235:genetics / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D018365:Neoplasm, Residual / Q000235:genetics / Q000473:pathology / Q000601:surgery; D011612:Psychosurgery; D012086:Reoperation; D013125:Spinal Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed