title: Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study.
abstract: The active form of vitamin B12 (methylcobalamin) has been reported to be effective on sleep-wake rhythm disorders. Previous studies, however, were performed under open trial, and the effect of vitamin B12 has not been properly evaluated. The aim of this double-blind study was to investigate the efficacy of methylcobalamin on delayed sleep phase syndrome (DSPS). Methylcobalamin (3 mg/day) or placebo was administered for 4 weeks. The subjects were 50 patients with DSPS aged 13-55 years (26.8 +/- 1.3), 27 of whom received the active drug while 23 received the placebo. No significant differences were observed between the 2 groups in subjective evaluations of mood or drowsiness during the daytime or in night sleep by sleep-log evaluation. These results indicate that 3 mg methylcobalamin administered over 4 weeks is not an effective treatment for DSPS.
authors.affiliation: National Institute of Mental Health, Ichikawa-shi, Jpan.
authors.forename: M
authors.initials: M
authors.lastname: Okawa
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Egashira
authors.forename: H
authors.initials: H
authors.lastname: Furuta
authors.forename: Y
authors.initials: Y
authors.lastname: Higashitani
authors.forename: T
authors.initials: T
authors.lastname: Higuchi
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ichimaru
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Ishizuka
authors.forename: N
authors.initials: N
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Kamei
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Kohsaka
authors.forename: T
authors.initials: T
authors.lastname: Komori
authors.forename: T
authors.initials: T
authors.lastname: Kotorii
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Mishima
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuki
authors.forename: K
authors.initials: K
authors.lastname: Morimoto
authors.forename: H
authors.initials: H
authors.lastname: Nagayama
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: N
authors.initials: N
authors.lastname: Okamoto
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000523:psychology; D014805:Vitamin B 12 / Q000097:blood / Q000627:therapeutic use*
chemical_list: D014805:Vitamin B 12