title: [Therapy with nasal CPAP (continuous positive airway pressure) in patients with obstructive sleep apnea syndrome (OSAS). I: Long-term acceptance of nasal CPAP].
abstract: BACKGROUND
  Nocturnal ventilation with nCPAP has been established as the safest and most efficient nonsurgical treatment for OSAS. Long-term results, however, are determined by the patients' compliance with therapy. The aim of this study was the objective measurement of long-term acceptability of nCPAP therapy in all patients receiving this treatment in our sleep laboratory between January 1990 and March 1995.
  
  
  METHODS
  We prospectively investigated 41 patients (36 male, 5 female) with moderate to severe OSAS who received nCPAP therapy. Mean time of follow-up was 20.6 months, ranging from 1.2 to 53.5 months. Therapy was indicated when OSAS was confirmed by cardiorespiratory polygraphy and either (1) the patient complained of daytime sleepiness or (2) the patient possessed an apnea-hypopnea index greater than 30/h or when the mean oxygen desaturation was below 80% regardless of the presenting symptoms. The compliance with treatment was defined as a mean rate of use of over 5 hours per night calculated from the time counter on the nCPAP machine.
  
  
  RESULTS
  33 patients (88.5%) have continued using nCPAP until the present time but only 24 patients (59%) met our criteria for long-term acceptance and this group was identified as responders. We found no significant differences in age, body mass index, apnea-hypopnea index, and nCPAP-pressure between responders and non-responders.
  
  
  CONCLUSIONS
  Although nCPAP is the safest treatment for OSAS, there is still a large group of patients with moderate to severe OSAS who are not efficiently treated with nCPAP because of the low long-term acceptability of this therapy. With respect to this group of patients, surgical approaches have to be considered as an alternative therapy.
authors.affiliation: HNO-Klinik der Medizinischen Universität zu Lübeck.
authors.forename: J H
authors.initials: JH
authors.lastname: Hollandt
authors.forename: S
authors.initials: S
authors.lastname: Kuhl
authors.forename: R
authors.initials: R
authors.lastname: Siegert
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008134:Long-Term Care / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D017286:Polysomnography; D011175:Positive-Pressure Respiration / Q000295:instrumentation*; D011446:Prospective Studies; D012891:Sleep Apnea Syndromes / Q000523:psychology / Q000628:therapy*; D016896:Treatment Outcome