Tissue synthesis of complement as an immune regulator.
Evidence is accumulating that a variety of tissues produce complement components, and that production in each tissue is differentially regulated by inflammatory cytokines. This locally produced complement could have protective or injurious actions, depending upon local circumstances. Techniques for analysing separately the contributions of local complement synthesis and complement derived from the circulation are now becoming available. We argue that an appreciation of the role of local complement synthesis may help to explain many features of organ- and tissue-specific immunological disease.
Andrews
P A
PA
Department of Nephrology, United Medical and Dental Schools, Guy's Hospital, London, UK.
Zhou
W
W
Sacks
S H
SH
D000818:Animals; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D003165:Complement System Proteins / Q000096:biosynthesis* / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007154:Immune System Diseases / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D007249:Inflammation; D007668:Kidney / Q000473:pathology; D008954:Models, Biological
D016207:Cytokines; D003165:Complement System Proteins