title: Insulin resistance in patients with familial combined hyperlipidemia and coronary artery disease.
abstract: The minimum model modified by the administration of insulin provides an objective and relatively easily measured index of peripheral sensitivity to insulin which was significantly lower (p <0.02) in familial combined hyperlipidemia (FCH) with ischemic heart disease (IHD) than in FCH without IHD and in control subjects (1.2 +/- 0.6, 1.9 +/- 1.0, 2.9 +/- 1.2 x 10(-4) mU/L/ min, respectively). In patients with FCH, insulin resistance explains, at least in part, their metabolic alterations (hypertension, abnormal glucose tolerance, hyperinsulinemia) and elevated IHD.
authors.affiliation: Service of Endocrinology and Nutrition, Hospital Clinico, University of Valencia, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Ascaso
authors.forename: R
authors.initials: R
authors.lastname: Lorente
authors.forename: A
authors.initials: A
authors.lastname: Merchante
authors.forename: J T
authors.initials: JT
authors.lastname: Real
authors.forename: A
authors.initials: A
authors.lastname: Priego
authors.forename: R
authors.initials: R
authors.lastname: Carmena
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D005951:Glucose Tolerance Test; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins