[Long-term survival after multimodal therapy for lung cancer with pleural dissemination].
A 56-year-old man with peripheral T1N0M0 lung cancer underwent thoracotomy. Pleural dissemination was recognized intraoperatively. We performed wedge resection of the lung including the primary tumor, and applied hypotonic cisplatin treatment. We followed this up postoperatively with chemotherapy combined with cisplatin and irinotecan. One year later, a recurrent tumor occurred at the resected end of the lung, so we conducted stereotactic radiosurgery on the recurrent lung lesion, resulting in complete eradication. One year later, no relapse of cancer was observed. We conclude that implementing hypotonic cisplatin treatment in pleural dissemination of lung cancer followed by stereotactic radiosurgery on any recurrent tumor in the peripheral lung was effective for the present case.
Horio
H
H
Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
Nomori
H
H
Morinaga
S
S
Fuyuno
G
G
Kobayashi
R
R
D000230:Adenocarcinoma / Q000556:secondary* / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000556:secondary* / Q000628:therapy; D016634:Radiosurgery; D017741:Survivors
D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin