Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells.
The primary CD8+ T-cell response protected most B-cell-deficient muMT mice against intranasal infection with the HKx31 influenza A virus. Prior exposure did not prevent reinfection upon homologous challenge, and the recall CD8+ T-cell response cleared the virus from the lung within 7 days. Depleting the CD8+ T cells substantially reduced the capacity of these primed mice to deal with the infection, in spite of evidence for established CD4+ T-cell memory. Thus, the control of this relatively mild influenza virus by both primary and secondary CD4+ T-cell responses is relatively inefficient in the absence of B cells and CD8+ T cells.
Topham
D J
DJ
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101-0318, USA.
Doherty
P C
PC
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D007156:Immunologic Memory; D009980:Influenza A virus / Q000276:immunology* / Q000472:pathogenicity*; D008211:Lymphocyte Cooperation; D008212:Lymphocyte Depletion; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000209:etiology / Q000276:immunology