Essential hypertension and abnormal upper airway resistance during sleep.
The epidemiological, clinical, hereditary, biochemical, hematological, and physiological characteristics of essential hypertension (EH) and obstructive sleep apnea (OSA) are reviewed here. This extensive review shows that essential hypertension and sleep-disordered breathing--independently of whether it is OSA syndrome or upper airway resistance syndrome--share strikingly similar characteristics. The accumulated data obtained by many different researchers support the hypothesis that EH is mainly due to increased upper airway resistance during sleep. If this hypothesis is correct, treating disorders that cause increased upper airway resistance, particularly during sleep, would be an important part of the treatment of essential hypertension.
Silverberg
D S
DS
Department of Nephrology, Tel Aviv Medical Center, Israel.
Oksenberg
A
A
D000367:Age Factors; D000402:Airway Obstruction / Q000150:complications*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology; D008297:Male; D011175:Positive-Pressure Respiration; D012737:Sex Factors; D012890:Sleep; D012891:Sleep Apnea Syndromes / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D012913:Snoring / Q000150:complications