Searching for migraine genes: exclusion of 290 cM out of the whole human genome.
A linkage and association analysis was made on 14 Italian families with recurrent migraine. We analyzed five chromosomal regions surrounding the candidate genes 5HT1D (1p36.3-34.3), 5HT1B (6q13), 5HT2A (13q14-21), 5HT transporter (17q11.2-12), CACNLB1 (17q11.2-22) and FHM (19p13), using 29 DNA polymorphic markers. All two-point lod scores were negative, and the chi 2 sib-pair analyses were not significant, thus indicating the probable exclusion of these regions as sites of migraine genes in our population.
Monari
L
L
Laboratorio di Neurogenetica, Università di Bologna, Italy.
Mochi
M
M
Valentino
M L
ML
Arnaldi
C
C
Cortelli
P
P
De Monte
A
A
Pierangeli
G
G
Prologo
G
G
Scapoli
C
C
Soriani
S
S
Montagna
P
P
D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis / Q000235:genetics; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008881:Migraine Disorders / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D011985:Receptors, Serotonin / Q000235:genetics
D011985:Receptors, Serotonin; D004247:DNA