[Gas chromatography and mass spectrometry method for detection of selected pyrethroid metabolites in urine].
Pyrethroids are increasingly used indoors, because of their low mammalian toxicity but high insecticidal activity. Indoor application of pyrethroids, which is often carried out without adequate expert knowledge, may lead to high pesticide residues, often combined with health hazards for the people concerned. Objective of the present study is the development of a method for a biological monitoring to determine internal exposure to pyrethroids. Major pyrethroid metabolites were detected in urine by capillary gas chromatography in combination with mass selective detection (MSD). For the metabolites, the limits of determination range between 0.5 and 1 microgram/L urine. Our results so far demonstrate the detectability of cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid (DVCA) and 3-phenoxybenzoic acid (3-PBA) in urine during a period of elimination of 48 hours after exposure to cypermethrin. In this paper the method is exemplary illustrated by one exposed person (pest control operator).
Leng
G
G
Institut für Hygiene, Heinrich-Heine-Universität Düsseldorf.
Kühn
K H
KH
Dunemann
L
L
Idel
H
H
D000328:Adult; D000393:Air Pollutants / Q000493:pharmacokinetics*; D000395:Air Pollutants, Occupational / Q000493:pharmacokinetics; D016902:Air Pollution, Indoor / Q000032:analysis*; D004784:Environmental Monitoring; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007306:Insecticides / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D009784:Occupational Diseases / Q000652:urine; D010571:Pest Control; D011722:Pyrethrins / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D007306:Insecticides; D011722:Pyrethrins