Remission of myasthenia gravis caused by proteinuria in nephrotic syndrome.
Myasthenia gravis is caused by antibodies against acetylcholine receptors and is treated with inhibition or elimination of antibody production. We report a 43-year-old myasthenic female who was symptomatic until she developed proteinuria from nephrotic syndrome, which caused a marked drop in acetylcholine receptor antibody titer with remission of myasthenia. Treatment of the nephrotic syndrome produced exacerbation of her myasthenia and a rise in antibody level. This patient's improvement is the result of antibody elimination during proteinuria in nephrotic syndrome.
Almsaddi
M
M
Department of Neurology, University of Tennessee Memphis, 38163, USA.
Bertorini
T E
TE
Bastnagel
W
W
D000328:Adult; D000906:Antibodies / Q000032:analysis; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications* / Q000276:immunology / Q000503:physiopathology*; D009404:Nephrotic Syndrome / Q000150:complications* / Q000652:urine*; D011507:Proteinuria / Q000209:etiology* / Q000503:physiopathology*; D011950:Receptors, Cholinergic / Q000276:immunology; D012075:Remission, Spontaneous
D000906:Antibodies; D011950:Receptors, Cholinergic