Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes.
The NKG2 family of genes encodes at least four different type II transmembrane molecules (NKG2-A, NKG2-B, NKG2-C and NKG2-E) which contain a C-lectin domain. These proteins have been shown to be covalently associated with CD94, another C-type lectin member. The heterodimers are involved in natural killer cell-mediated recognition of different HLA-allotypes. Here we describe the cloning of a new NKG2-related gene, termed NKG2-F, localized 25 kb from NKG2-A as well as its relationship with the previously described NKG2-D cDNA. Despite the similarities with the other NKG2 genes, NKG2-F encodes a putative protein which does not contain any lectin domain. However, a conserved 24-amino acid sequence, present in all members of the NKG2 family, suggests that NKG2-F is also able to form heterodimers with CD94.
Plougastel
B
B
Human Immunogenetics Laboratory, Imperial Cancer Research Fund, London, GB. plougast@icrf.icnet.uk
Trowsdale
J
J
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D006801:Humans; D007694:Killer Cells, Natural / Q000737:chemistry / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000276:immunology*; D055654:NK Cell Lectin-Like Receptor Subfamily C; D055655:NK Cell Lectin-Like Receptor Subfamily K; D016366:Open Reading Frames / Q000276:immunology; D012326:RNA Splicing / Q000276:immunology; D011971:Receptors, Immunologic / Q000235:genetics* / Q000302:isolation & purification; D055607:Receptors, Natural Killer Cell; D014158:Transcription, Genetic / Q000276:immunology
C527054:KLRC1 protein, human; C527059:KLRC2 protein, human; C527062:KLRC3 protein, human; C527066:KLRC4 protein, human; C527085:KLRK1 protein, human; D008562:Membrane Glycoproteins; D055654:NK Cell Lectin-Like Receptor Subfamily C; D055655:NK Cell Lectin-Like Receptor Subfamily K; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell