title: Meconium ileus: a ten-year review of thirty-six patients.
abstract: Of 36 neonates with meconium ileus secondary to cystic fibrosis treated over a 10-year period, twenty-one (58%) had simple uncomplicated disease while fifteen (42%) had complications which included perforation (5), volvulus (6) and atresia (5). Gastrografin enema was employed in 20 infants with relief of obstruction in 8 (40%). Operative procedures consisted of resection and primary anastomosis in seventeen patients, stomas were fashioned in six, three had an enterotomy with irrigation only and two had Bishop-Koop enterostomy. Post-operative complications developed in 5 (18%) of these 28 patients. The overall survival rate was 97%. The one death occurred in an infant with short bowel syndrome, patent ductus arteriosus, hydrocephalus and pulmonary damage. There were eight additional patients who had meconium obstruction in the absence of cystic fibrosis.
authors.affiliation: Great Ormond Street Hospital for Children, London, UK.
authors.forename: R
authors.initials: R
authors.lastname: Murshed
authors.forename: L
authors.initials: L
authors.lastname: Spitz
authors.forename: E
authors.initials: E
authors.lastname: Kiely
authors.forename: D
authors.initials: D
authors.lastname: Drake
mesh_terms: D003550:Cystic Fibrosis / Q000150:complications*; D003974:Diatrizoate Meglumine / Q000627:therapeutic use; D004733:Enema; D004766:Enterostomy; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D007231:Infant, Newborn; D007409:Intestinal Atresia / Q000150:complications; D007415:Intestinal Obstruction / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D007416:Intestinal Perforation / Q000150:complications; D008131:London / Q000453:epidemiology; D008297:Male; D008470:Meconium; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D003974:Diatrizoate Meglumine