title: Semi-automated extraction of brain contours from MRI.
abstract: We compared brain volumes computed by trained operators using the BRAIN-MAP algorithm, which automatically extracts the contours of the brain from gradient-echo magnetic resonance images. The images of 19 subjects randomly selected from a group of normals and a group of patients with dementia were included. BRAIN-MAP found brain perimeters that were on the average ca. 3% tighter than those obtained by two experienced operators. Between-operator and within-operator reproducibility of the analyses were also estimated and found to be (-0.13 +/- 0.51)% and (-0.63 +/- 0.08)%, respectively. Replicate volume measurement by the computer alone provided a reproducibility of (0.44 +/- 0.46)%.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: H T
authors.initials: HT
authors.lastname: Ong
authors.forename: J
authors.initials: J
authors.lastname: Tieman
authors.forename: M
authors.initials: M
authors.lastname: Albert
authors.forename: F
authors.initials: F
authors.lastname: Jolesz
authors.forename: T
authors.initials: T
authors.lastname: Sandor
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology; D003704:Dementia / Q000473:pathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results