title: Comparison of patient reactions and diagnostic quality for hysterosalpingography using ionic and nonionic contrast media.
abstract: OBJECTIVE
  We compared adverse reactions and image quality for hysterosalpingography (HSG) performed with ionic (diatrizoate meglumine combined with iodipamide meglumine [DM + IM]) and nonionic (iohexol) contrast media.
  
  
  METHODS
  We performed a study of 95 patients who had HSG and were randomly selected to receive DM + IM or iohexol. Patients reported episodes of abdominal pain and other adverse reactions immediately and 24 hr after the procedure and categorized severity of symptoms on a subjective scale. Two radiologists evaluated image quality for diagnosis.
  
  
  RESULTS
  Prevalence of abdominal pain and other reactions both immediately and 24 hr after HSG was lower in patients who received iohexol than in patients who received DM + IM. Moderate or severe abdominal pain was significantly lower in the iohexol group than in the DM + IM group (p < .05). Visualization of the uterine cavity and ampullary rugae was judged excellent with both contrast media (87% with iohexol and 92% with DM + IM).
  
  
  CONCLUSIONS
  Iohexol and DM + IM are excellent contrast media for use during HSG; iohexol 300 may cause fewer episodes of more severe and prolonged abdominal pain.
authors.affiliation: Department of Radiology, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1088, USA.
authors.forename: M Y
authors.initials: MY
authors.lastname: Chen
authors.forename: R J
authors.initials: RJ
authors.lastname: Zagoria
authors.forename: J A
authors.initials: JA
authors.lastname: Fayez
authors.forename: D J
authors.initials: DJ
authors.lastname: Ott
authors.forename: F L
authors.initials: FL
authors.lastname: Van Swearingen
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced*; D000328:Adult; D016009:Chi-Square Distribution; D003287:Contrast Media / Q000009:adverse effects*; D003974:Diatrizoate Meglumine / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications; D005260:Female; D006801:Humans; D007047:Hysterosalpingography / Q000009:adverse effects* / Q000295:instrumentation; D007458:Iodipamide / Q000009:adverse effects*; D007472:Iohexol / Q000009:adverse effects*; D008875:Middle Aged; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; D003974:Diatrizoate Meglumine; D007472:Iohexol; D007458:Iodipamide