title: The origin of lactate in peritumoral edema as measured by proton-magnetic resonance spectroscopic imaging.
abstract: Using in vivo proton-magnetic resonance spectroscopy (1H-MRS), which allows the measurement of metabolites of adequate tissue concentration, the origin of lactate in peritumoral edema has been assessed by comparison with lactate levels in the central and marginal areas of the tumor in 18 patients with cerebral gliomas. In the majority of cases lactate content in the area of peritumoral edema was lower than that in the tumor margin or tumor center, which is consistent with the assumption that the tumor is the source of lactate, which then reaches the surrounding area of edema by diffusion. In 3 of the 18 cases the amount of lactate in the peritumoral edematous tissue was higher than in the tumor, indicating that the lactate is locally produced on account of ischemia due to regional elevation of tissue pressure in the edematous area.
authors.affiliation: Department of Neurosurgery, University Hospital Groningen, The Netherlands.
authors.forename: K G
authors.initials: KG
authors.lastname: Go
authors.forename: A P
authors.initials: AP
authors.lastname: Krikke
authors.forename: R L
authors.initials: RL
authors.lastname: Kamman
authors.forename: M A
authors.initials: MA
authors.lastname: Heesters
mesh_terms: D001929:Brain Edema / Q000209:etiology / Q000378:metabolism*; D001932:Brain Neoplasms / Q000150:complications / Q000378:metabolism*; D005910:Glioma / Q000150:complications / Q000378:metabolism*; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons
chemical_list: D011522:Protons; D019344:Lactic Acid