New anionic polyelectrolyte hydrogel for corneal surgery.
A new high-water-content (78%) anionic polyelectrolyte hydrogel was obtained by phase inversion (demixion) of a polymer solution containing 9.0% poly(acrylonitrile sodium methallylsulphonate), 85.0% dimethylformamide, and 6.0% saline solution (0.9% NaCl). The hydrogel is permeable to water, saline, urea, creatinine, glucose, human albumin, and saline-dissolved oxygen. Investigation of the interactions between human serum and surfaces prepared with the new yielded hydrogel, compared to serum interaction with silica-free silicone (RTV), regenerated cellulose (Cuprophan), MMA/PVP copolymer (Lidofilcon), PMMA (Perspex), FIFE (Gore-Tex), and poly(acrylonitrile sodium methallylsulphonate) hemodialysis membrane (AN-69), showed the hydrogel and hemodialysis membrane (both prepared with AN-69 copolymer) to be the only materials devoid of complement (C')-activating ability.
Honiger
J
J
INSERM, Bioengineering Laboratory, Hôpital Saint-Antoine, Paris, France.
Couturier
C
C
Goldschmidt
P
P
Maillet
F
F
Kazatchkine
M D
MD
Laroche
L
L
D001672:Biocompatible Materials / Q000737:chemistry / Q000633:toxicity; D003167:Complement Activation / Q000187:drug effects; D003315:Cornea / Q000601:surgery*; D004573:Electrolytes / Q000737:chemistry / Q000633:toxicity; D005782:Gels; D006801:Humans; D066298:In Vitro Techniques; D007688:Kidneys, Artificial; D008422:Materials Testing; D008567:Membranes, Artificial; D010100:Oxygen; D010539:Permeability; D000071228:Polyelectrolytes; D011108:Polymers / Q000737:chemistry / Q000633:toxicity; D012031:Refractometry; D013314:Stress, Mechanical; D014867:Water
D001672:Biocompatible Materials; D004573:Electrolytes; D005782:Gels; D008567:Membranes, Artificial; D010100:Oxygen; D000071228:Polyelectrolytes; D011108:Polymers; D014867:Water