title: Tetracycline fibers plus scaling and root planing versus scaling and root planing alone: similar results after 5 years.
abstract: This paper presents 5-year data pertaining to a subgroup of patients from a previous investigation who were treated with scaling and root planing plus tetracycline fibers. The parent study demonstrated that 6 months after therapy, scaling and root planing plus tetracycline fiber therapy was significantly better at reducing probing depth and gaining clinical attachment than scaling and root planing alone. However, the long-term data presented here show a regression from the original gains in clinical attachment levels in the fiber group. Ultimately, the use of fibers provided no significant advantage with regards to probing depth reduction or clinical attachment gain. Within the power of this study, which would have required 1.78 mm of change in clinical attachment to show a difference, there was no significant difference between the treatments at 5 years. This study underscores the need for additional long-term evaluation of this mode of therapy.
authors.affiliation: Department of Biostatistics and Dental Public Health Sciences, University of Washington, Seattle, USA. perio@onramp.net
authors.forename: T G
authors.initials: TG
authors.lastname: Wilson
authors.forename: M K
authors.initials: MK
authors.lastname: McGuire
authors.forename: G
authors.initials: G
authors.lastname: Greenstein
authors.forename: M
authors.initials: M
authors.lastname: Nunn
mesh_terms: D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D012534:Dental Scaling; D004343:Drug Implants; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000188:drug therapy / Q000628:therapy; D005889:Gingival Recession / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D008137:Longitudinal Studies; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000628:therapy; D010510:Periodontal Diseases / Q000188:drug therapy / Q000628:therapy*; D010514:Periodontal Pocket / Q000188:drug therapy / Q000628:therapy; D012008:Recurrence; D016745:Root Planing; D016037:Single-Blind Method; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D004343:Drug Implants; D013752:Tetracycline