Micronuclei formation in bone marrow cells of rats treated with meothrin (synthetic pyrethroid).
The production of micronuclei in rat bone marrow cells by the synthetic pyrethroid insecticide meothrin was investigated. Three different doses of meothrin were orally administered to rats for 14 consecutive days. All tested doses of meothrin increased the frequency of micronucleated polychromatic erythrocytes but the increase was statistically significant only at the two highest doses. Meothrin also affected the rate of bone marrow cell proliferation, as determined by changes in the ratio of polychromatic erythrocytes to normochromatic erythrocytes.
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Cell Biology Unit, National Research Center, Cairo, Egypt.
D000284:Administration, Oral; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D007306:Insecticides / Q000494:pharmacology*; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects* / Q000235:genetics; D015162:Micronucleus Tests; D009570:Nitriles; D011722:Pyrethrins / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C109802:meothrin