title: Immunological functions of adult T cell leukemia cells of a patient complicated with synchronous double primary gynecologic cancer.
abstract: A patient with triple malignancies is reported, who presented cervical cancer, vulvar cancer and adult T cell leukemia (ATL). ATL was diagnosed as a smouldering type, because antibody to human T cell leukemia virus associated antigen (ATLA) was positive with a titer of 1:160. Although her malignant cells had an OKT 4+8-3+Tac+ phenotype, the cells did not display helper T cell functions. Namely they showed no response to Phytohemagglutinin (PHA) and Interleukin 2 (IL-2) and suppressed the PWM driven IgG synthesis of B cells obtained from healthy donor. They did not produce IL-2 by stimulation with PHA and phorbol myristate acetate (PMA). Furthermore, these ATL cells were producing IL-2 inhibitor like factors. As synchronous triple malignancies are extremely rare, two gynecologic cancers seem to ascribe to the suppressing state of the immunosurveillance mechanism by viral infection.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tokushima School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Furumoto
authors.forename: M
authors.initials: M
authors.lastname: Kamada
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Katsura
authors.forename: M
authors.initials: M
authors.lastname: Irahara
authors.forename: T
authors.initials: T
authors.lastname: Aono
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015458:Leukemia, T-Cell / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D009378:Neoplasms, Multiple Primary; D016609:Neoplasms, Second Primary; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000473:pathology; D014846:Vulvar Neoplasms / Q000276:immunology* / Q000473:pathology