title: Combined antegrade-retrograde blood cardioplegia does not protect right ventricle better than either technique alone in patients with occluded right coronary artery.
abstract: To study the hypothesis that combined antegrade-retrograde delivery of cardioplegia might overcome the limitations in myocardial protection of either technique alone, we compared the distribution of the different cardioplegic approaches by assessing myocardial cooling and evaluated the effects on right ventricular (RV) function in elective coronary artery bypass grafting (CABG) patients with occluded right coronary artery (RCA). In a randomized trial, 15 patients received exclusively antegrade (ante group), 14 patients received exclusively retrograde (retro group) and 15 patients received combined, alternating antegrade-retrograde (combi group) cold blood cardioplegia. Myocardial temperatures were measured at four sites in the heart. Right ventricular function was assessed by determining the ejection fraction (fast-response thermodilution) and preload-related RV stroke work in repeated measurements. Myocardial cooling was similarly uneven and the posterior wall of the RV remained above 20 degrees C after all three methods of delivering hypothermic (5-7 degrees C) cardioplegia. The RV ejection fraction and preload-related (right atrial pressure) RV stroke work decreased postoperatively similarly in all groups. The results suggest that combined antegrade-retrograde cold blood cardioplegia could not provide more homogeneous myocardial cooling or better RV recovery than either technique alone in three-vessel-diseased CABG patients with occluded RCA.
authors.affiliation: Department of Anaesthesia and Intensive Care, Tampere University Hospital, Medical School of the University of Tampere, Finland.
authors.forename: E L
authors.initials: EL
authors.lastname: Honkonen
authors.forename: L
authors.initials: L
authors.lastname: Kaukinen
authors.forename: E J
authors.initials: EJ
authors.lastname: Pehkonen
authors.forename: S
authors.initials: S
authors.lastname: Kaukinen
mesh_terms: D001769:Blood; D002314:Cardioplegic Solutions; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000379:methods*; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery*; D017558:Elective Surgical Procedures; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D011446:Prospective Studies; D013318:Stroke Volume; D016278:Ventricular Function, Right
chemical_list: D002314:Cardioplegic Solutions