title: The distal colon provides reserve storage capacity during colonic fluid overload.
abstract: BACKGROUND
  In addition to its absorptive function the capacity of the colon to retain fluid might be relevant in compensating for increased fluid loads and prevention of diarrhoea. The distal colon is considered to be mainly a conduit without extensive storage function.
  
  
  OBJECTIVE
  To evaluate colonic volume capacity in a model of pure osmotic diarrhoea.
  
  
  METHODS
  A non-absorbable, iso-osmotic solution (OS) containing polyethylene glycol (500 ml) was infused into the caecum of nine healthy volunteers; the control group (n = 5) received an equal amount of an easily absorbable electrolyte solution (ES). Fluids were radiolabelled with technetium-99m and gamma camera images were obtained for 48 hours. Counts in the proximal and distal colon were measured and regional and overall colonic transit and stool output were quantified.
  
  
  RESULTS
  After OS, in contrast to ES, faecal output was increased significantly (p < 0.05), but colonic transit after OS was not different from transit after ES (p > 0.05). This indicates storage of OS in the colon: after OS infusion, counts in the proximal colon decreased linearly while the distal colon stored approximately 30% of radioactivity for the whole 48 hour study period. After OS, stool output correlated with distal (p < 0.01), but not with proximal (p > 0.05), colonic transit. In contrast, after ES, stool output was determined by proximal colonic transit (p < 0.05) but not by transit through the distal colon (p > 0.05).
  
  
  CONCLUSIONS
  The distal colon retains non-absorbable fluid volumes extensively. In our model transit through the distal colon--but not the proximal colon--determined the time at which diarrhoea occurred.
authors.affiliation: AKH Wien, Universitätsklinik für Innere Medizin IV, Abteilung für Gastroenterologie und Hepatologie, Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Hammer
authors.forename: M
authors.initials: M
authors.lastname: Pruckmayer
authors.forename: H
authors.initials: H
authors.lastname: Bergmann
authors.forename: K
authors.initials: K
authors.lastname: Kletter
authors.forename: A
authors.initials: A
authors.lastname: Gangl
mesh_terms: D000328:Adult; D003106:Colon / Q000378:metabolism*; D003967:Diarrhea / Q000378:metabolism*; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D009995:Osmosis; D011092:Polyethylene Glycols; D013997:Time Factors
chemical_list: D011092:Polyethylene Glycols