title: The lymphoproliferation mutation in Fas locally unfolds the Fas death domain.
abstract: NMR studies of the lymphoproliferation mutant (V238N) of the Fas death domain indicate that helix 3 is unfolded. This local structural change abolishes binding to FADD--a protein that interacts with Fas and also contains a death domain--and causes the accumulation of autoreactive T cells.
authors.forename: M
authors.initials: M
authors.lastname: Eberstadt
authors.forename: B
authors.initials: B
authors.lastname: Huang
authors.forename: E T
authors.initials: ET
authors.lastname: Olejniczak
authors.forename: S W
authors.initials: SW
authors.lastname: Fesik
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000235:genetics*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D019463:Mice, Inbred MRL lpr; D008969:Molecular Sequence Data; D009154:Mutation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D019014:fas Receptor / Q000737:chemistry* / Q000235:genetics*
chemical_list: D019014:fas Receptor