The retinoblastoma protein pathway in cell cycle control and cancer.
Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine.
Bartek
J
J
Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark.
Bartkova
J
J
Lukas
J
J
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D009857:Oncogenes; D016160:Retinoblastoma Protein / Q000502:physiology*
D016160:Retinoblastoma Protein; D018844:Cyclin-Dependent Kinases