Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation.
The present investigation has examined the clinical benefits of tobramycin, polymyxin E and amphotericin therapy in the management of oral mucositis in children undergoing chemotherapy prior to bone marrow transplantation. Tobramycin, polymyxin E, and amphotericin reduced the degree of oral mucositis more than conventional therapy of diphenhydramine, Maalox, and local analgesic. While there was a statistically significant fall in the severity of the mucositis with tobramycin, polymyxin E and amphotericin, this was unlikely to be of practical benefit.
Bondi
E
E
University of Bologna, School of Dentistry, Bologna, Italy.
Baroni
C
C
Prete
A
A
Gatti
M
M
Carrassi
A
A
Lodi
G
G
Porter
S R
SR
D000293:Adolescent; D000536:Aluminum Hydroxide / Q000627:therapeutic use; D000666:Amphotericin B / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003091:Colistin / Q000627:therapeutic use; D004155:Diphenhydramine / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008012:Lidocaine / Q000627:therapeutic use; D008276:Magnesium Hydroxide / Q000627:therapeutic use; D009061:Mouth Mucosa; D013280:Stomatitis / Q000139:chemically induced / Q000188:drug therapy*; D014031:Tobramycin / Q000627:therapeutic use; D019172:Transplantation Conditioning / Q000009:adverse effects*
D000970:Antineoplastic Agents; D004338:Drug Combinations; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D000666:Amphotericin B; D004155:Diphenhydramine; D008012:Lidocaine; D008276:Magnesium Hydroxide; D014031:Tobramycin; D003091:Colistin