title: Excretion of epidermal growth factor in human adult polycystic kidney disease.
abstract: In chronic renal failure, epidermal growth factor (EGF) excretion is decreased. In this study, asymptomatic adult polycystic kidney disease (APKD) patients with a relatively preserved glomerular filtration rate were examined. Excretion of EGF was studied in 6 patients with APKD (median age 42 years; serum creatinine [median] 95 [range-80-133] mumol/l) and compared with that of 28 healthy controls. EGF was determined in a spot morning urine by using a specific radioimmunoassay, and expressed in relation to creatinine excretion. Excretion of EGF in APKD was (median) 157 (range-13-359) and in the controls (median) 546 (range-238-1199) pmol/mmol creatinine (p < 0.001). Low excretion of EGF in APKD patients with preserved kidney function suggests a distal abnormality at an early stage of the disease, prior to the development of renal failure.
authors.affiliation: Department of Nephrology, Rabin Medical Center-Golda (Hasharon) Campus, Petah-Tikva.
authors.forename: T
authors.initials: T
authors.lastname: Weinstein
authors.forename: D
authors.initials: D
authors.lastname: Hwang
authors.forename: A
authors.initials: A
authors.lastname: Lev-Ran
authors.forename: Y
authors.initials: Y
authors.lastname: Ori
authors.forename: A
authors.initials: A
authors.lastname: Korzets
authors.forename: J
authors.initials: J
authors.lastname: Levi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D004815:Epidermal Growth Factor / Q000502:physiology / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology; D007686:Kidney Tubules, Distal / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000150:complications / Q000503:physiopathology / Q000652:urine*; D011863:Radioimmunoassay
chemical_list: D004815:Epidermal Growth Factor; D003404:Creatinine