The role of high risk HPV lymph node positivity in the surgical staging of cancer of the uterine cervix.
The presence of oncogenic Human Papillomavirus (HPV) DNAs in cervical carcinomas and their normal and metastatic pelvic lymph nodes is studied worldwide. Does the HPV positivity without histological metastasis in the lymph nodes mean an early prognostic indicator in the progress of the disease? The authors analyzed the surgical, histological and virological data of four cervical cancer patients, whose recurrence occurred very early and died soon. After performing radical hysterectomy with precise removal of the pelvic lymph nodes, they assessed the operative specimens by routine histology and detected for HPV types by PCR. All the four lymph nodes harboured HPV-18 subtype in spite of negative histology in three cases. Thus the authors consider that if the lymph nodes contain any type of high-risk HPVs maybe despite negative histology or early stage of cancer we have to treat the patient as if she had an advanced cervical cancer.
Sápy
T
T
Department of Obstetrics and Gynecology, University Medical School of Debrecen, Hungary.
Hernádi
Z
Z
Lukácskó
L
L
Borsos
A
A
D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary / Q000601:surgery / Q000821:virology; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary / Q000601:surgery / Q000821:virology; D002423:Cause of Death; D004279:DNA, Viral / Q000235:genetics; D018450:Disease Progression; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000821:virology*; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000821:virology; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology; D016133:Polymerase Chain Reaction; D011379:Prognosis; D015996:Survival Rate; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology
D004279:DNA, Viral