title: [A case of polymyalgia rheumatica with swelling and pitting edema of the distal lower extremities].
abstract: We report a case of an 82-year-old woman with polymyalgia rheumatica (PMR) associated with swelling and pitting edema of the lower extremities. The patient had been previously admitted because of PMR in 1990, but there was no history of swollen extremities. In July 1996, at another hospital, she was again diagnosed as having PMR on the basis of pain in the neck, shoulders and lower back. Administration of prednisolone was followed by improvement of the symptoms. Four months later, similar pain recurred and swelling of the lower extremities was noted. On admission, the erythrocyte sedimentation rate was 86 mm/h, and C-reactive protein was 15.5 mg/dl. Reviewing the previous treatment, it was ascertained that her clinical deterioration was due to premature reduction of the steroid dosage. The cause of the swelling of the lower extremities was unlikely to be heart, liver, kidney or endocrine disease. Prednisolone was increased from 2.5 mg to 10 mg daily with marked improvement in all the symptoms including the swelling and pitting edema. In 1996, a study reported distal extremity swelling with pitting edema as a manifestation of PMR, which mostly developed concurrently with proximal symptoms or during relapses of PMR. The swelling responded poorly to non-steroidal antiinflammatory drugs but promptly to corticosteroids. The distal swelling was reported to be tenosynovitis and synovitis of the surrounding structures. The present case appears similar to that report. More studies of PMR need to be done.
authors.affiliation: Department of General Medicine, Saga Medical School.
authors.forename: S
authors.initials: S
authors.lastname: Imanaka
authors.forename: K
authors.initials: K
authors.lastname: Yoshihara
authors.forename: S
authors.initials: S
authors.lastname: Koizumi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004487:Edema / Q000209:etiology*; D005260:Female; D006801:Humans; D007866:Leg; D011111:Polymyalgia Rheumatica / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage; D013717:Tenosynovitis / Q000209:etiology
chemical_list: D011239:Prednisolone