Tumor necrosis factor-alpha, interleukin-1-beta and immunoglobulin (GM and KM) polymorphisms in leprosy. A linkage study.
In order to determine the genetic components of susceptibility to leprosy in 6 multiplex French Polynesian families, linkage analysis was carried out between a putative disease gene and 6 polymorphic loci: G1M, G2M, KM, IL-1 beta, TNF-alpha (1, 2) and TNF-alpha (A, G) using the lod score method. The three modes of inheritance, assuming a full penetrance value or reduced penetrance values (80 and 40%) for the susceptible allele, as well as with affected ones only, were tested. The results of this study provide no evidence for linkage between leprosy and the markers tested.
Levée
G
G
Institut Territorial de Recherches Médicales Louis Malardé Papeete, Tahiti, French Polynesia.
Schurr
E
E
Pandey
J P
JP
D004198:Disease Susceptibility; D008040:Genetic Linkage; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D007375:Interleukin-1 / Q000235:genetics*; D007918:Leprosy / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha