title: [Study of Lavoisier morphine chlorhydrate stability in different active perfusion systems after reconstitution in different solvents].
abstract: The stability of morphine chlorhydrate injectable solutions with no preservative used for drug delivery system (PCA) was investigated. Many concentrations of morphine chlorhydrate were prepared using different solvents and in several containers: PCA cartridges and plastic syringes stored at 37 degrees C. Assays of drug substance and of degradation products were determined at different time within 14 days. In such conditions, morphine chlorhydrate solutions were stable: degradation products were quantitated less than the usual normal i.e. 2% of the theoric concentration of the drug.
authors.affiliation: Laboratoires Chaix et du Marais, Spécialités pharmaceutiques Lavoisier, La Chaussée St-Victor.
authors.forename: B
authors.initials: B
authors.lastname: Truelle-Hugon
authors.forename: G
authors.initials: G
authors.lastname: Tourrette
authors.forename: B
authors.initials: B
authors.lastname: Couineaux
authors.forename: C
authors.initials: C
authors.lastname: Gache-Charrette
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D004355:Drug Stability; D009022:Morphine Derivatives / Q000008:administration & dosage; D012997:Solvents / Q000494:pharmacology
chemical_list: D000701:Analgesics, Opioid; D009022:Morphine Derivatives; D012997:Solvents