title: Bicyclic [b]-heteroannelated pyridazine derivatives. Part 5. Synthesis of some triazolo[4,3-b]pyridazine and pyridazino[6,1-c]triazine derivatives as potential benzodiazepine receptor ligands.
abstract: 4-Substituted-tetrahydropyridazine-3,6-dione 3-hydrazones [I] reacted with strong carboxylic acids and some acyl chlorides to give the N-acylation products and/or triazolo[4,3-b]pyridazine derivatives. Derivatives of this bicyclic structure were obtained also in reactions of I with triethyl orthoformate and orthoacetate. In the reaction with phosgene, triazolo[4,3-b]pyridazine-3,6-dione, and with oxalyl chloride pyridazino[6,1-c]triazine-3,4,7-trione derivatives were obtained.
authors.affiliation: Department of Technology and Biotechnology of Drugs, University of Technology, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Lange
authors.forename: K
authors.initials: K
authors.lastname: Wejroch
authors.forename: J
authors.initials: J
authors.lastname: Karolak-Wojciechowska
authors.forename: J
authors.initials: J
authors.lastname: Plenkiewicz
authors.forename: M
authors.initials: M
authors.lastname: Gniewosz
authors.forename: H
authors.initials: H
authors.lastname: Tondys
authors.forename: P
authors.initials: P
authors.lastname: Ruzikowski
authors.forename: S
authors.initials: S
authors.lastname: Rump
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000378:metabolism; D011724:Pyridazines / Q000138:chemical synthesis* / Q000378:metabolism; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism; D014227:Triazines / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D001643:Bridged Bicyclo Compounds; D011724:Pyridazines; D011963:Receptors, GABA-A; D014227:Triazines