title: Exhausted subjects, exhausted systems.
abstract: A state of 'vital exhaustion', characterized by unusual tiredness, increased irritability and feelings of demoralization has been found to preceed the onset of myocardial infarction and to increase the risk of a new coronary event after angioplasty. Probably this state reflects a decreased activity of the hypothalamic-pituitary-adrenal axis as part of an homeostatic reaction to prolonged stress and inflammation.
authors.affiliation: Department of Medical Psychology, University of Maastricht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Appels
mesh_terms: D000328:Adult; D000368:Aged; D005221:Fatigue / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000523:psychology / Q000601:surgery