Some aspects of the effects of PL-10.1.AK-15 on the gastrointestinal tract.
PL-10.1.AK-15 is an active fragment of a naturally occurring protein first isolated from human gastric juice. Among its other protective effects, PL-10.1.AK-15 has demonstrated a protective effect on the gastrointestinal tract. The aim of this study was to investigate the influence of PL-10.1.AK-15 on two functional parameters of gastrointestinal function: gastric acid secretion and gastrointestinal motility. Gastric acid secretion was assessed in male Wistar rats using a modified method of Shay, while gastrointestinal motility was assessed in male NMRI mice by charcoal propulsion. PL-10.1.AK-15 was given in three different doses (3, 10 and 100 micrograms/kg body weight) in accordance with the experimental protocol. The results of these experiments indicate that PL-10.1.AK-15 in the investigated doses had no influence on gastric acid secretion or gastrointestinal motility.
Erceg
D
D
Pliva Pharmaceutical Company, Biomedical Department, Zagreb, Croatia.
Simicevic
V N
VN
Kolega
M
M
Dohoczky
C
C
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004064:Digestive System / Q000187:drug effects* / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010446:Peptide Fragments / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000897:Anti-Ulcer Agents; D010446:Peptide Fragments; D011506:Proteins; C083833:BPC 157