[The therapy of equine sarcoid with a non-specific immunostimulator--the epidemiology and spontaneous regression of sarcoids].
20 sarcoid-affected horses from a practice in the northern Jura were used in this experiment. The mean age of the 20 horses was 3.9 years at the time of the first observation of sarcoid tumors. On the average, 4.4 tumours were noted per horse. 10 of the horses were treated in a double-blind study with an unspecific immunostimulant (Baypamun P), 10 others received a placebo. One single tumour only was treated per horse. The injections were given under and around the sarcoid. In eight out of the 20 horses all tumours regressed totally or for more than 50% of their initial size. Five of these had received placebo, three the immunostimulant. Four animals showed a modest, but measurable reduction in tumour size (3 immuno-stimulant, 1 placebo) and in the remaining eight horses (4:4) no reduction or even an increase in tumour size was observed. The phenomenon of tumour regression was very probably due to spontaneous regression and horses which had been observed to develop sarcoid within the last three months had significantly more regressions than animals with older tumours (p < 0.05). The haplotype of the equine leucocyte antigens was thought to predispose 12 of the 20 horses for the sarcoid. However, the ELA-type did not measurably influence the phenomenon of tumour regression.
Studer
U
U
Clinique du Vieux Château Delémont.
Marti
E
E
Stornetta
D
D
Lazary
S
S
Gerber
H
H
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D004311:Double-Blind Method; D005260:Female; D006239:Haplotypes; D006734:Horse Diseases / Q000453:epidemiology / Q000628:therapy*; D006736:Horses; D015552:Injections, Intralesional / Q000662:veterinary; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D012878:Skin Neoplasms / Q000453:epidemiology / Q000628:therapy / Q000662:veterinary*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; C076692:Baypamun HK; D014765:Viral Vaccines