Prevention of peritoneal metastasis of cancer with dextran sulfate--an experimental study in mice.
Peritoneal metastases occur most often in the greater omentum, where tumor implantation sites are densely distributed. We used dextran sulfate (S-Dex) as an anti-cell-adherence agent to prevent i.p. seeded malignant cells from causing peritoneal metastases. S-Dex was tested for its anti-adherent activity against B-16 melanoma cells on plastic, and was examined for its ability to prevent implantation in the omentum and to improve survival in mice after B-16 melanoma was inoculated i.p. S-Dex prevented B-16 melanoma cells from adhering to the plastic wall. S-Dex reduced the number of B-16 melanoma cells implanted into the greater omentum and improved the survival of mice inoculated with B-16 melanoma cells. We conclude that S-Dex attenuated peritoneal metastases when B-16 melanoma cells were seeded i.p.
Hagiwara
A
A
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Sawai
K
K
Sakakura
C
C
Shirasu
M
M
Ohgaki
M
M
Imanishi
T
T
Yamasaki
J
J
Togawa
T
T
Takahashi
T
T
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D016264:Dextran Sulfate / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D009368:Neoplasm Transplantation; D009852:Omentum / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D016019:Survival Analysis
D016264:Dextran Sulfate