title: [Sequential treatment with granulocyte-colony stimulating factor (GCSF) and human recombinant erythropoietin (rH-EPO) in anemia of a patient with myelodysplastic syndrome and high blood transfusion requirements)].
abstract: We describe the case of a patient with myelodysplastic syndrome (MDS) classified as Refractory Anemia with our Excess blasts, who suffered from high transfusional requirements and who did not respond to the administrations of B12 vitamin, folates, danazol, low dose cytarabine or recombinant human erythropoietin (rHuEPO). The patient was administered two cytokines: granulocyte colony stimulating factor (G-CSF) followed by rHuEPO. The patient remained transfusion free for more than 4 months until his death from causes not related to MDS or the therapy he received. It is the opinion of the authors that the initial G-CSF administration stimulated the early erythroid precursors, making them capable of finishing their maturation when rHuEPO was administered. We believe that this could be a useful therapeutic measure in the treatment of patients with MDS and high transfusional requirements.
authors.affiliation: Servicio de Hematología Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad Social y Servicios de los Trabajadores del Estado, México, D.F. rafael@borbolla.com
authors.forename: J R
authors.initials: JR
authors.lastname: Borbolla-Escoboza
authors.forename: C M
authors.initials: CM
authors.lastname: González-Avante
authors.forename: M A
authors.initials: MA
authors.lastname: López-Hernández
authors.forename: J D
authors.initials: JD
authors.lastname: Flores-Chapa
authors.forename: M T
authors.initials: MT
authors.lastname: Collados-Larumbe
mesh_terms: D000753:Anemia, Refractory / Q000628:therapy*; D017707:Erythrocyte Transfusion; D004921:Erythropoietin / Q000627:therapeutic use*; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor