[The role of serotonin in the embryogenesis of normal and irradiated mouse embryos].
We have examined the role of serotonin, a neurotransmitter, in the development of normal embryos and embryos irradiated in utero at different stages of morpho- and organogenesis. We have found that serotonin is capable of attenuating radiation-induced disturbances of development; serotonin therapeutic action varied depending on the age of the embryo, severity of the original radiation damage, and the time that serotonin was administered after irradiation. All data provide evidence that the window of serotonin's therapeutic effect is strictly timed to a certain stage of prenatal ontogenesis, specifically, to neurogenesis. This conclusion is in agreement with the view that serotonin serves as a morphogenetic signal for the developing nervous system, the state of which is important for the viability and functionality of fetuses in the normal state and after exposure to ionizing irradiation.
Konstantinova
M M
MM
Turpaev
T M
TM
Panaeva
S V
SV
Podmarëva
O N
ON
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005314:Embryonic and Fetal Development / Q000187:drug effects* / Q000528:radiation effects*; D005260:Female; D005865:Gestational Age; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011247:Pregnancy; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology
D011837:Radiation-Protective Agents; D012701:Serotonin