title: The role of CT and MR in imaging the complications of sickle cell disease.
abstract: Sickle cell disease is the most common inherited haemoglobinopathy described. Complications of sickle cell disease (SCD) are due to chronic haemolysis of fragile red cells or secondary to vascular occlusion by sickled red cells with subsequent tissue infarction. Traditionally plain film radiography has been the mainstay in the assessment of patients with SCD, but increasingly magnetic resonance (MR) imaging and computed tomography (CT) are being used. In this review the imaging features of a range of complications of SCD are demonstrated with particular emphasis on CT and MR.
authors.affiliation: Department of Radiology, Guy's and St Thomas' NHS Trust, St Thomas' Hospital, London, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Howlett
authors.forename: A G
authors.initials: AG
authors.lastname: Hatrick
authors.forename: J M
authors.initials: JM
authors.lastname: Jarosz
authors.forename: J B
authors.initials: JB
authors.lastname: Bingham
authors.forename: T C
authors.initials: TC
authors.lastname: Cox
authors.forename: A T
authors.initials: AT
authors.lastname: Irvine
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D001927:Brain Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D052776:Female Urogenital Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D052801:Male Urogenital Diseases; D009140:Musculoskeletal Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D014057:Tomography, X-Ray Computed