The effect of exercise on lymphocyte redistribution and leucocyte function in asymptomatic HIV-infected subjects.
This study was undertaken to examine the responsiveness of circulating leucocyte and lymphocyte populations to the physiological demands of exercise in asymptomatic HIV-infected subjects with CD4+ counts greater than 500/microliter. Thirteen subjects infected with HIV and 14 control subjects underwent 20 min of defined moderate exercise at estimated 65% of their maximal ventilatory capacity on a bicycle ergometer. Blood samples were obtained for serum cortisol, norepinephrine, lymphocyte subsets (CD4, CD8, CD19, CD16-CD56), and phagocytic function at rest immediately after exercise and 20 min following the cessation of the exercise. The HIV-infected subjects had increased circulating concentrations of CD8 cells (p = .007) and CD16-CD56+ NK cells (p = .02) in response to the exercise, whereas the control group did not. There was a greater increase in monocyte respiratory burst activity following recovery from exercise in the control subjects (p = .016) but not in the HIV-infected subjects. The control subjects experienced an increase in serum cortisol in response to the exercise (p = .006), but the HIV-infected subjects did not. Our results show that the changes in the distribution and function of circulating leucocytes and adrenal neuroendocrine responses to moderate exercise differ in asymptomatic HIV-infected and control subjects.
Phillips
E J
EJ
St. Michael's Hospital, Department of Medicine, University of Toronto, Canada.
Ottaway
C A
CA
Freedman
J
J
Kardish
M
M
Li
J
J
Singer
W
W
Fong
I W
IW
D000328:Adult; D015444:Exercise / Q000502:physiology*; D006679:HIV Seropositivity / Q000276:immunology* / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007962:Leukocytes / Q000502:physiology*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D010587:Phagocytosis / Q000276:immunology / Q000502:physiology; D010641:Phenotype; D010809:Physical Fitness; D016897:Respiratory Burst / Q000502:physiology
D006854:Hydrocortisone; D009638:Norepinephrine