title: In pursuit of drugs for American trypanosomiasis: evaluation of some "standards" in a mouse model.
abstract: Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective as the reference drug, nifurtimox. A major value of the present data is to demonstrate the refractoriness of the T. cruzi parasite against many of the drug standards that have known biological activity.
authors.affiliation: Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Kinnamon
authors.forename: B T
authors.initials: BT
authors.lastname: Poon
authors.forename: W L
authors.initials: WL
authors.lastname: Hanson
authors.forename: V B
authors.initials: VB
authors.lastname: Waits
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D004195:Disease Models, Animal; D005260:Female; D007099:Imipramine / Q000737:chemistry / Q000627:therapeutic use; D007654:Ketoconazole / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D009547:Nifurtimox / Q000627:therapeutic use; D009550:Nigericin / Q000627:therapeutic use; D009560:Niridazole / Q000627:therapeutic use; D011530:Protriptyline / Q000737:chemistry / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000981:Antiprotozoal Agents; D011530:Protriptyline; D009547:Nifurtimox; D009560:Niridazole; D007099:Imipramine; D007654:Ketoconazole; D009550:Nigericin