title: The effect of intravenous diazepam on solid phase gastric emptying in normal cats.
abstract: Intravenous diazepam has been advocated as an appetite stimulant in anorexic cats. Diazepam has also been used to stimulate the intake of radiographic contrast medium-food mixture to determine the gastric emptying time of a solid meal. Diazepam has been suspected to delay gastric emptying in cats. One study found diazepam combined with valium to have little effect on gastric transit times in cats while diazepam alone accelerates gastric emptying in humans. The purpose of this study was to determine if diazepam influences gastric emptying times in normal cats. The gastric emptying half-time of solid food in normal, non-diazepam treated cats has been previously determined using a scintigraphic technique using 99mTc-sulfur colloid to radiolabel solid dry food. The median gastric emptying half-time was 2.3 hours and the mean meal size was 16.1 grams. Gastric emptying half-times were determined in this study using diazepam as an appetite stimulant. The median gastric emptying half-times of diazepam treatment groups given both a 16.1 gram meal and a large meal were both significantly longer than the normal non-treated group (P < 0.05). Solid phase gastric emptying is therefore significantly delayed when diazepam is used as an appetite stimulant, irrespective of the volume of the meal.
authors.affiliation: Department of Radiological Health Sciences, College of Veterinary Medicine and Biological Sciences Colorado State University, Fort Collins 80523, USA.
authors.forename: P F
authors.initials: PF
authors.lastname: Steyn
authors.forename: D
authors.initials: D
authors.lastname: Twedt
authors.forename: W
authors.initials: W
authors.lastname: Toombs
mesh_terms: D000818:Animals; D002415:Cats; D003975:Diazepam / Q000494:pharmacology*; D005746:Gastric Emptying / Q000187:drug effects*; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D013671:Technetium Tc 99m Sulfur Colloid; D003975:Diazepam