title: Basal cell carcinomas arising over arteriovenous malformations: some speculations on the theme.
abstract: The modulating effects of mesoderm on ectoderm during the embryonic period have been well documented. Some cutaneous conditions such as dermatofibroma with basaloid proliferation are examples of such a relationship. Seven cases of basal cell carcinoma (BCC) developing in port-wine stains and one case developing over an arteriovenous (AV) malformation have been reported. We report 3 elderly patients with BCC developing over AV malformations of the lower extremities. The association between BCC and AV malformation range from a chance association to a complex interaction between mesenchyme and epithelium, in which mesenchyme induces and modulates epithelial growth through the elaboration of specific growth factors (GF).
authors.affiliation: Department of Pathology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Feinmesser
authors.forename: E
authors.initials: E
authors.lastname: Taube
authors.forename: E
authors.initials: E
authors.lastname: Badani
authors.forename: D
authors.initials: D
authors.lastname: Kristt
mesh_terms: D000169:Acrodermatitis / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D001165:Arteriovenous Malformations / Q000150:complications*; D002280:Basal Cell Carcinoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D012514:Sarcoma, Kaposi / Q000473:pathology; D012867:Skin / Q000166:cytology / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology