The trental treatment prevents the reduction of superoxide dismutase enzyme (SOD) activity in rats after colon surgery.
The authors tested the effects of the pentoxiphyllin (px, Trental) pre-treatment upon the superoxide dismutase activity of the left colonpart anastomosis of rats. It has been found that the SOD activity of the proximal (4.9 U/g), the anastomical area (1.9 U/g) and the distal (3.1 U/g) intestinal segments considerably decreased, compared to the control (9.16 U/g). In the operated and pre-treated animals with Trental, the SOD activity of all the three intestinal segments increased (proximal 15.5-anastomosis 5.7-distal 8.9 U/g) compared to the non treated group.
Schweitzer
K
K
Department of Pathophysiology, Research Centre of Military Medicine, Haynal University of Health Sciences, Budapest, Hungary.
Ender
F
F
Pittner
J
J
Fürész
J
J
D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000187:drug effects / Q000201:enzymology / Q000473:pathology / Q000601:surgery*; D012809:Colon, Sigmoid / Q000187:drug effects / Q000201:enzymology / Q000473:pathology / Q000601:surgery; D005609:Free Radicals / Q000378:metabolism; D008297:Male; D010431:Pentoxifylline / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D011292:Premedication; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D005609:Free Radicals; D010726:Phosphodiesterase Inhibitors; D014665:Vasodilator Agents; D013482:Superoxide Dismutase; D010431:Pentoxifylline