The transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice.
In Escherichia coli, the SoxRS regulon is required for resistance to redox-cycling agents which elevate cytosolic superoxide levels, as well as for resistance to nitric oxide-dependent macrophage killing. In Salmonella typhimurium, SoxS is also required for enhanced expression of Mn-superoxide dismutase and resistance to paraquat, but not for resistance to nitric oxide donor compounds in vitro, resistance to macrophage killing, or virulence in mice. Differences in other antioxidant defense systems or compensation by homologous regulons may account for species-specific differences in the role of SoxS.
Fang
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FC
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA. ferric.fang@uchsc.edu
Vazquez-Torres
A
A
Xu
Y
Y
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D051379:Mice; D010269:Paraquat / Q000494:pharmacology*; D012481:Salmonella Infections, Animal / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000235:genetics* / Q000472:pathogenicity*; D013045:Species Specificity; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics*; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C070725:SoxS protein, E coli; D010269:Paraquat