title: Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin.
abstract: In patients with acute liver failure, cerebral herniation is a common cause of death. The present study reports the effect of indomethacin on four occasions of intracranial hypertension, in a 23-year old previously healthy woman with severe acetaminophen poisoning. During each episode of intracranial hypertension, the patient was treated with 25 mg of indomethacin, and each time the intracranial pressure normalized. We recommend further controlled studies to determine the exact effect of indomethacin on cerebral blood flow and metabolism before it is recommended for treatment of intracranial hypertension in patients with acute liver failure.
authors.affiliation: Department of Hepatology, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: J O
authors.initials: JO
authors.lastname: Clemmesen
authors.forename: B A
authors.initials: BA
authors.lastname: Hansen
authors.forename: F S
authors.initials: FS
authors.lastname: Larsen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D019586:Intracranial Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007427:Intracranial Pressure / Q000187:drug effects* / Q000502:physiology; D017093:Liver Failure / Q000150:complications*; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin