Multislice measurement of first-pass transit of gadobenate dimeglumine in normal and ischemic myocardium in dogs.
OBJECTIVE
We monitored the differences in the first passage of gadobenate dimeglumine through normal and ischemic myocardium with left anterior descending (LAD) coronary artery occlusion in dogs.


METHODS
Dynamic multislice images of the heart were taken on a 1.5-T magnetic resonance (MR) imager. In six normal dogs, inversion recovery (IR)-prepared fast gradient-recalled echo (GRE) images were acquired at five doses of gadobenate dimeglumine (0.005-0.1 mmol/kg). First passage of the contrast medium through normal and acutely ischemic myocardium were monitored in seven dogs subjected to LAD coronary artery occlusion.


RESULTS
IR-prepared GRE images showed a dose-dependent increase in the signal intensity (SI) of the myocardium. In dogs with LAD coronary artery occlusion, there was a significant increase in the SI of normal myocardium (p < .01) than in ischemic myocardium after injection of 0.025 mmol/kg gadobenate dimeglumine.


CONCLUSIONS
The first-pass dynamics of gadobenate dimeglumine through normal and ischemic myocardium can be monitored with a multislice acquisition using a clinical MR imager and differentiated between normal and ischemic myocardium in dogs.
Sakuma
H
H
Department of Radiology, University of California, San Francisco 94143-0628, USA.
Wendland
M F
MF
Saeed
M
M
Derugin
N
N
Geschwind
J F
JF
Lauerna
K
K
Mintorovitch
J
J
Cavagna
F M
FM
Higgins
C B
CB
D000818:Animals; D003287:Contrast Media; D004285:Dogs; D005682:Gadolinium; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine / Q000031:analogs & derivatives*; D017202:Myocardial Ischemia / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology; D009942:Organometallic Compounds
D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D005682:Gadolinium