title: Coagulation techniques are not important in directing blood product transfusion during liver transplantation.
abstract: Preoperative acquired clotting parameters such as prothrombin time, activated partial thromboplastin time, antithrombin III, platelet concentration, and fibrinogen show coagulopathy caused by insufficiency of the diseased liver. Intraoperative determination of clotting factors or parameters is not helpful to direct intraoperative transfusion of blood, blood components, or platelets because transfusions performed solely for correction of clotting data do not correlate with the real intraoperative requirements and increase the costs of orthotopic liver transplantation. However, the use of antihyperfibrinolytic drugs seems to reduce intraoperative blood loss. Patients with cirrhotic disorders caused by portalvenous hypertension show extensive collaterals and increased intravascular blood volume. Thus it is plausible that especially overcorrection of blood loss during the surgical preparation in the preanhepatic phase of the operation results in extensive blood loss. Therefore, to avoid blood loss we attempt to keep volume substitution to a minimum during the preanhepatic phase of the operation. In contrast, during the anhepatic and postanhepatic phases we attempt to reestablish normovolemia by transfusing red packed blood cells and fresh-frozen plasma. Strictly confined use of blood products in the preanhepatic phase, followed by later correction of intravascular blood volume, may reduce intraoperative blood loss; it also seems to ensure adequate substitution of clotting factors.
authors.affiliation: Klinik für Anaesthesiologie und operative Intensivmedizin Virchow-Klinikum der Humboldt-Universität, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Reyle-Hahn
authors.forename: R
authors.initials: R
authors.lastname: Rossaint
mesh_terms: D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D016913:Blood Component Transfusion; D006488:Hemostasis, Surgical; D006801:Humans; D007432:Intraoperative Period; D016031:Liver Transplantation / Q000502:physiology*; D008991:Monitoring, Physiologic