Dose-response relationship of fibrous dusts in intraperitoneal studies.
The relationship between the number of fibers injected intraperitoneally and the occurrence of peritoneal mesotheliomas in rats was investigated using data from a series of carcinogenicity studies with several fibrous dusts. Based on observed tumor incidences ranging between 10 and 90%, the hypothesis of a common slope of dose-response relationships (parallel probit lines in probit analysis) cannot be rejected. In general, parallelism of probit lines is considered an indication of a common mode of action. Analysis of the shape of the dose-response relationship, with one apparent exception, shows virtually linear or superlinear behavior, i.e., from these data, there is no indication of a decrease in carcinogenic potency of an elementary carcinogenic unit at lower doses.
Roller
M
M
Department of Experimental Hygiene, Heinrich Heine University, Düsseldorf, Germany.
Pott
F
F
Kamino
K
K
Althoff
G H
GH
Bellmann
B
B
D000818:Animals; D001194:Asbestos / Q000008:administration & dosage / Q000633:toxicity; D017554:Carbon Compounds, Inorganic / Q000008:administration & dosage / Q000633:toxicity; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004391:Dust / Q000009:adverse effects*; D005260:Female; D007274:Injections, Intraperitoneal; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced / Q000473:pathology; D019016:Mineral Fibers / Q000633:toxicity*; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D017655:Silicon Compounds / Q000008:administration & dosage / Q000633:toxicity
D017554:Carbon Compounds, Inorganic; D002273:Carcinogens; D004391:Dust; D019016:Mineral Fibers; D017655:Silicon Compounds; D001194:Asbestos; C022088:silicon carbide