title: Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene.
abstract: Y chromosome molecular analysis was performed using the STS-PCR technique in 50 patients with oligozoospermia. Microdeletions of interval 6 of the Y chromosome were detected in seven patients, in six of whom subinterval E was affected. All patients retained the RBM1 and DAZ genes, while in one deletion involved the SPGY gene. The size of the deletion was not apparently related to the severity of the disease. These results suggest the presence of an oligozoospermia critical region on the Y chromosome within subinterval E of interval 6.
authors.affiliation: Cattedra di Genetica Umana, Università, G D'Annunzio, Chieti, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Stuppia
authors.forename: V
authors.initials: V
authors.lastname: Gatta
authors.forename: G
authors.initials: G
authors.lastname: Mastroprimiano
authors.forename: F
authors.initials: F
authors.lastname: Pompetti
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: P
authors.initials: P
authors.lastname: Guanciali Franchi
authors.forename: E
authors.initials: E
authors.lastname: Morizio
authors.forename: R
authors.initials: R
authors.lastname: Mingarelli
authors.forename: M
authors.initials: M
authors.lastname: Nicolai
authors.forename: R
authors.initials: R
authors.lastname: Tenaglia
authors.forename: L
authors.initials: L
authors.lastname: Improta
authors.forename: V
authors.initials: V
authors.lastname: Sforza
authors.forename: S
authors.initials: S
authors.lastname: Bisceglia
authors.forename: G
authors.initials: G
authors.lastname: Palka
mesh_terms: D000328:Adult; D002872:Chromosome Deletion; D000075364:Deleted in Azoospermia 1 Protein; D006801:Humans; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D009845:Oligospermia / Q000235:genetics*; D016133:Polymerase Chain Reaction; D016601:RNA-Binding Proteins / Q000235:genetics*; D014998:Y Chromosome
chemical_list: C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D016601:RNA-Binding Proteins