Embryonic and adult expression patterns of the Tec tyrosine kinase gene suggest a role in megakaryocytopoiesis, blood vessel development, and melanogenesis.
The Tec cytoplasmic tyrosine kinase is a member of a family of src-like proteins that are thought to play important roles in hematopoiesis. Here we describe the temporal and spatial expression of the Tec gene during embryogenesis and in the adult. Our data demonstrate that embryonic Tec expression is restricted to distinct hematopoietic cells as well as structures and cell types that share a common feature of containing fluid in an enclosed cavity, e.g., endothelial cells. In addition, Tec is expressed in melanocytes late in gestation. The observed developmental expression pattern of Tec suggests a role for this gene in several aspects of hematopoiesis and/or blood vessel development as well as in late stages of melanogenesis.
Klüppel
M
M
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto Ontario, Canada.
Donoviel
D B
DB
Brunkow
M E
ME
Motro
B
B
Bernstein
A
A
D000818:Animals; D001808:Blood Vessels / Q000196:embryology / Q000254:growth & development; D015152:Blotting, Northern; D005314:Embryonic and Fetal Development / Q000235:genetics* / Q000502:physiology; D015870:Gene Expression; D006410:Hematopoiesis / Q000235:genetics*; D017403:In Situ Hybridization; D008533:Megakaryocytes / Q000166:cytology / Q000502:physiology*; D008544:Melanocytes / Q000166:cytology / Q000502:physiology; D051379:Mice; D018919:Neovascularization, Physiologic / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D019170:Somites / Q000502:physiology
D012333:RNA, Messenger; C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases