An experimental porcine model of partial ischaemia of the distal colon.
OBJECTIVE
Ischaemia of the colon is a major challenge in aortoiliac surgery. The aim was to establish an animal model of partial distal colonic ischaemia to study interventional strategies.


METHODS
Randomised experiment.


METHODS
University Hospital. Department of Experimental Research.


METHODS
19 pigs.


METHODS
11 Pigs were subjected to ischaemia consisting of total occlusion of the inferior mesenteric artery and partial occlusion of the superior mesenteric artery. Eight animals were sham controls. Dextran was given.


METHODS
Haemodynamic measurements, intramucosal pH-measurements (pHi) and histological grading.


RESULTS
Both ischaemic animals and controls remained haemodynamically stable. It was possible to maintain stable ischaemia in the distal colon in the pHi-range of 6.9-7.1. There was histological mucosal damage of the distal colon in ischaemic animals but not in controls.


CONCLUSIONS
The model could be of value when studying interventional strategies to reduce or reverse ischaemia.
Björck
M
M
Department of Surgery, Skellefteå District Hospital, Sweden. martin@bjorck.pp.se
Bergqvist
D
D
Rasmussen
I
I
Piehl
E
E
Haglund
U
U
D000818:Animals; D003106:Colon / Q000098:blood supply* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006439:Hemodynamics; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008638:Mesenteric Arteries; D011897:Random Allocation; D013552:Swine