Arterial baroreflex modulation of heat-induced vasodilation in the rabbit ear.
The purpose of this study was to determine whether nonthermal baroreflexes arising from cardiopulmonary and/or arterial baroreceptors modulate rabbit ear blood flow (EBF) during hyperthermia. Intact and sinoaortic-denervated (SAD) rabbits were chronically instrumented with a Doppler ultrasonic flow probe for measurement of EBF velocity (kHz). During whole body heating in conscious rabbits, EBF and ear vascular conductance (EVC) increased as core temperature increased until maximal plateau levels of EBF and EVC were reached. The maximal plateau level of EVC attained during heat stress was lower in SAD than in intact rabbits. Subsequent intrapericardial administration of procaine at maximal EBF blocked cardiac afferents but did not alter EVC in either animal group. In a second experiment, ramp decreases in mean arterial pressure were produced by vena caval occlusion at maximal EBF. In intact rabbits, EBF and EVC decreased linearly as mean arterial pressure fell, but EBF and EVC did not decrease during vena caval occlusion in SAD rabbits. Thus neither pharmacological nor mechanical unloading of cardiac baroreceptors results in reflex vasoconstriction in the heat-stressed rabbit ear. However, baroreflexes arising from arterial baroreceptors may modulate EBF in heat-stressed rabbits.
Ryan
K L
KL
Department of Physiology, The University of Texas Health Science Center, San Antonio, Texas 78284-7764, USA.
Taylor
W F
WF
Bishop
V S
VS
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology; D004431:Ear, External / Q000098:blood supply*; D005260:Female; D018882:Heat Stress Disorders / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006358:Hot Temperature / Q000009:adverse effects*; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology; D011342:Procainamide / Q000494:pharmacology; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012849:Sinoatrial Node / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D000889:Anti-Arrhythmia Agents; D011342:Procainamide