Warm ischaemia time in a model for small bowel transplantation.
Intestinal transplantation is associated with high rates of mortality and morbidity. This paper details our initial experience with 82 heterotopic small bowel transplants based upon the original rat model described by Monchik and Russell (Surgery 70:693-702, 1971). A key issue associated with mortality was a warm ischaemia time of more than 40 min (P < 0.01). Sixty-eight percent of the recipients (44/65) survived for more than 24 hr when the warm ischaemia time of the donor bowel was reduced to less than 40 min. Investigators establishing an animal model of heterotopic small bowel transplantation should pay particular attention to the warm ischaemia time of the donor bowel.
Giele
H P
HP
University Department of Surgery, Royal Perth Hospital, Australia.
Heel
K A
KA
Storrie
A
A
McCauley
R D
RD
Hall
J C
JC
D000818:Animals; D004195:Disease Models, Animal; D006085:Graft Survival; D007421:Intestine, Small / Q000098:blood supply* / Q000637:transplantation*; D007511:Ischemia / Q000503:physiopathology*; D011183:Postoperative Complications / Q000401:mortality; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000401:mortality; D013997:Time Factors