title: [Time-dependent effect of metoprolol in middle-aged and old patients with angina].
abstract: As shown by X-ray clinical and laboratory examinations of 495 patients over 18 years of age with primary tuberculosis of the respiratory organs, among primary forms of the specific process most prevalent are tuberculosis of the intrathoracic lymph nodes (tumor form), infiltrative tuberculosis with preroot or lower lobe location and exudative pleurisy. The peak of the incidence was reported in the group of 20-25-year-olds. The disease took an cute course with severe intoxication and symptoms of bronchopulmonary involvement in 45.3%, a torpid course with scare symptoms in 49.7% and a chronic course of primary tuberculosis in 5.0% of the examinees. Paraspecific reactions were observed in 5.9%, hyperergic tuberculin tests typical for primary tuberculosis in 10.9% of the cases. The examination of the sputum for bacterial and altered forms of M. tuberculosis raised frequency of the diagnosis verification by 16.0%. Respiratory tuberculosis in adults runs in the presence of marked disorders in lymphocyte T- and B-systems, antituberculous immunity and metabolic processes. Incidence rate and intensity of the above disorders correlate with severity of tuberculous intoxication and tuberculous lesions. The informative value of the complex of clinicoroentgenological and immunological tests in the diagnosis of primary tuberculosis varies from 44.4 to 79.6% and from 28.3 to 77.5% in dependence on the immunological and biochemical test, respectively.
authors.affiliation: Moskovskiĭ meditsinskiĭ stomatologicheskiĭ institut, Aktiubinskiĭ gosudarstvennyĭ meditsinskiĭ institut.
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Petukhova
authors.forename: R M
authors.initials: RM
authors.lastname: Zaslavskaia
authors.forename: M M
authors.initials: MM
authors.lastname: Teĭblium
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000367:Age Factors; D000787:Angina Pectoris / Q000188:drug therapy*; D002940:Circadian Rhythm / Q000187:drug effects; D006801:Humans; D008790:Metoprolol / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D000319:Adrenergic beta-Antagonists; D008790:Metoprolol