Metoclopramide plasma concentration in neonates.
During the course of a multiple-dose metoclopramide (M) oral treatment, M plasma concentrations were measured just before (Cmin) and 1 hour after the administration (C1h) at steady-state in 5 (3 premature and 2 term) neonates. Mean Cmin was equal to 91.6 +/- 45.5 ng/ml and higher than C1h (87.4 +/- 43.2 ng/ml), but not significantly. A significant negative correlation was found between Cmin plasma concentration and gestational age as well as with postconceptional age, suggesting that the lower the gestational and postconceptional age, the lower the metoclopramide dosage should be.
Vauzelle-Kervroedan
F
F
Service de Pharmacologie Perinatale et Pédiatrique, Université René Descartes Paris V, France.
Rey
E
E
D'Athis
P
P
Badoual
J
J
Olive
G
G
Pons
G
G
D002648:Child; D002851:Chromatography, High Pressure Liquid; D018492:Dopamine Antagonists / Q000097:blood* / Q000493:pharmacokinetics; D006801:Humans; D008787:Metoclopramide / Q000097:blood* / Q000493:pharmacokinetics
D018492:Dopamine Antagonists; D008787:Metoclopramide