title: Update on intraoperative analysis of mandibular margins.
abstract: OBJECTIVE
  Assessing the adequacy of the surgical resection during composite resection of carcinoma is limited by the ability to evaluate the bone margins. The standard pathologic evaluation of bone is by decalcification.
  
  
  METHODS
  A method of analysis was devised based on histologically proven methods of cortical invasion and subsequent spread. Frozen-section analysis of cancellous bone was investigated as a rapid method of evaluating adequacy of the mandibular resection. This report is an update of previously published results and includes an increase in the sample size as well as the analysis of additional pathology. Subjects consisted of 66 patients undergoing full thickness mandibular resection with 30 cases of histologically proven mandibular invasion qualifying for evaluation. Results on frozen section were then compared to the permanent section analysis on the cancellous bone and to the decalcified specimen.
  
  
  RESULTS
  Complete correlation was found between frozen and permanent section results. Frozen section analysis was able to correctly predict adequacy of resection in 60 of 61 margins.
  
  
  CONCLUSIONS
  Based on these results, the oncologic surgeon can evaluate bone margins at the time of the resection and adjust the amount of excision required to eradicate the disease.
authors.affiliation: Department of Otolaryngology, Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Research Institute, Ohio State University, Columbus, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Forrest
authors.forename: D E
authors.initials: DE
authors.lastname: Schuller
authors.forename: B
authors.initials: B
authors.lastname: Karanfilov
authors.forename: J G
authors.initials: JG
authors.lastname: Lucas
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008339:Mandibular Neoplasms / Q000473:pathology* / Q000601:surgery*; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009361:Neoplasm Invasiveness; D011446:Prospective Studies