Vitamin B12 treatment for delayed sleep phase syndrome: a multi-center double-blind study.
The active form of vitamin B12 (methylcobalamin) has been reported to be effective on sleep-wake rhythm disorders. Previous studies, however, were performed under open trial, and the effect of vitamin B12 has not been properly evaluated. The aim of this double-blind study was to investigate the efficacy of methylcobalamin on delayed sleep phase syndrome (DSPS). Methylcobalamin (3 mg/day) or placebo was administered for 4 weeks. The subjects were 50 patients with DSPS aged 13-55 years (26.8 +/- 1.3), 27 of whom received the active drug while 23 received the placebo. No significant differences were observed between the 2 groups in subjective evaluations of mood or drowsiness during the daytime or in night sleep by sleep-log evaluation. These results indicate that 3 mg methylcobalamin administered over 4 weeks is not an effective treatment for DSPS.
Okawa
M
M
National Institute of Mental Health, Ichikawa-shi, Jpan.
Takahashi
K
K
Egashira
K
K
Furuta
H
H
Higashitani
Y
Y
Higuchi
T
T
Ichikawa
H
H
Ichimaru
Y
Y
Inoue
Y
Y
Ishizuka
Y
Y
Ito
N
N
Kamei
K
K
Kaneko
M
M
Kim
Y
Y
Kohsaka
M
M
Komori
T
T
Kotorii
T
T
Matsumoto
M
M
Mishima
K
K
Mizuki
Y
Y
Morimoto
K
K
Nagayama
H
H
Ohta
T
T
Okamoto
N
N
Takahashi
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000523:psychology; D014805:Vitamin B 12 / Q000097:blood / Q000627:therapeutic use*
D014805:Vitamin B 12