title: Iodinated nanoparticles for indirect computed tomography lymphography of the craniocervical and thoracic lymph nodes in normal dogs.
abstract: OBJECTIVE
  We evaluated the imaging characteristics of an interstitially or intraperitoneally delivered iodinated particulate contrast agent for computed tomography (CT) lymphography of the craniocervical and thoracic lymph nodes.
  
  
  METHODS
  We injected 2-4 ml of 15% wt/vol iodinated nanoparticle suspension subcutaneously, submucosally, or intraperitoneally in eight normal dogs. CT and plain radiographic images were obtained prior to contrast administration and 4 hr, 24 hr, and 7 days after injection. Correlation was made to detailed postmortem assessment.
  
  
  RESULTS
  CT images showed enhancement of regional nodes draining injection sites. Mean attenuation of opacified nodes was 313 +/- 297 (mean +/- standard deviation), 536 +/- 453, and 492 +/- 372 Hounsfield units at 4 hr, 24 hr, and 7 days postinjection, respectively. Lymph node opacification on CT images correlated well with node location found at postmortem.
  
  
  CONCLUSIONS
  Craniocervical and thoracic lymph nodes can be effectively opacified from interstitial or intraperitoneal delivery of this iodinated nanoparticulate contrast agent.
authors.affiliation: Department of Radiology, University of California Davis Medical Center, Sacramento 95817, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Wisner
authors.forename: R W
authors.initials: RW
authors.lastname: Katzberg
authors.forename: P D
authors.initials: PD
authors.lastname: Koblik
authors.forename: D K
authors.initials: DK
authors.lastname: Shelton
authors.forename: P E
authors.initials: PE
authors.lastname: Fisher
authors.forename: S M
authors.initials: SM
authors.lastname: Griffey
authors.forename: C
authors.initials: C
authors.lastname: Drake
authors.forename: P P
authors.initials: PP
authors.lastname: Harnish
authors.forename: A R
authors.initials: AR
authors.lastname: Vessey
authors.forename: P J
authors.initials: PJ
authors.lastname: Haley
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D003973:Diatrizoate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004285:Dogs; D006257:Head; D008198:Lymph Nodes / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D008220:Lymphography / Q000295:instrumentation / Q000379:methods*; D009333:Neck; D010316:Particle Size; D013909:Thorax; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*
chemical_list: D003287:Contrast Media; D003973:Diatrizoate; C089670:ethyl diatrizoate