title: Transection and occlusion of lateral semicircular canal in guinea pigs.
abstract: Audiologic and histopathologic examinations were made after occlusion of the lateral semicircular canal in eight guinea pigs. The lateral semicircular canal was drilled out, and then the canal lumens were plugged with muscle pieces. After a serial recording of auditory brain stem responses for 2 months, histologic specimens of the temporal bones were prepared in the lateral semicircular canal plane. One animal developed profound hearing loss due to suppurative labyrinthitis. The other seven animals showed no significant threshold elevation during this period. Histopathologic examination revealed that the bone defect on the lateral canal was replaced with newly formed bone; the perilymphatic and endolymphatic spaces maintained their compartmentalization; and the membranous endolymphatic canal healed to form complete blind ducts. These findings suggest that proper management of the injured semicircular canal is important for maintenance of postoperative hearing.
authors.affiliation: Department of Otolaryngology, Chungnam National University School of Medicine, Taejeon, South Korea.
authors.forename: B H
authors.initials: BH
authors.lastname: Nam
authors.forename: S K
authors.initials: SK
authors.lastname: Yoon
authors.forename: C I
authors.initials: CI
authors.lastname: Park
mesh_terms: D000818:Animals; D001309:Auditory Threshold; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000209:etiology; D008297:Male; D010012:Osteogenesis; D011183:Postoperative Complications / Q000209:etiology; D012665:Semicircular Canals / Q000293:injuries / Q000473:pathology* / Q000601:surgery*; D014945:Wound Healing