title: Detection of malignant and benign breast lesions with an automated US system: results in 120 cases.
abstract: OBJECTIVE
  To evaluate clinically an automated ultrasound (US) system for detecting benign and malignant breast lesions.
  
  
  METHODS
  A prototype automated US system was used to examine 119 patients: 38 patients with 39 proved malignant breast lesions (7-50 mm), 41 patients with 41 proved benign breast lesions (8-40 mm), and 40 patients without breast lesions. The device yields a three-dimensional set of B-mode scans and reconstructed US images comparable to mammograms. All patients had undergone mammography. Four radiologists who had not performed the examinations independently assessed the mammograms and US images to detect benign and malignant breast lesions.
  
  
  RESULTS
  Each of the four readers did not recognize one to three detectable malignant lesions on mammograms, one to two detectable malignant lesions on US images, two to four detectable benign lesions on mammograms, and five to seven detectable benign lesions on US images. All readers identified the 39 cancers with at least one of the modalities. The 40 cases without lesions were diagnosed correctly more frequently on the US images by three readers and on the mammograms by one reader.
  
  
  CONCLUSIONS
  Depiction of breast lesions at automated US is reproducible. Automated US is complementary to mammography.
authors.affiliation: Department of Radiology, Charité Medical School, Humboldt University of Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Richter
authors.forename: S H
authors.initials: SH
authors.lastname: Heywang-Köbrunner
authors.forename: K J
authors.initials: KJ
authors.lastname: Winzer
authors.forename: K J
authors.initials: KJ
authors.lastname: Schmitt
authors.forename: H
authors.initials: H
authors.lastname: Prihoda
authors.forename: H D
authors.initials: HD
authors.lastname: Frohberg
authors.forename: H
authors.initials: H
authors.lastname: Guski
authors.forename: P
authors.initials: P
authors.lastname: Gregor
authors.forename: J U
authors.initials: JU
authors.lastname: Blohmer
authors.forename: F
authors.initials: F
authors.lastname: Fobbe
authors.forename: K
authors.initials: K
authors.lastname: Döinghaus
authors.forename: G
authors.initials: G
authors.lastname: Löhr
authors.forename: B
authors.initials: B
authors.lastname: Hamm
mesh_terms: D001941:Breast Diseases / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D016217:Ultrasonography, Mammary / Q000295:instrumentation