Novel therapeutic directions for Parkinson's disease.
Problems associated with the long-term use of L-dopa to treat Parkinson's disease have prompted considerable interest in developing alternative therapeutic strategies for this disorder. Newer approaches have included dopamine-cell transplantation, genetic manipulation of striatal cells in situ and the localized administration of trophic factors to injured neurons in the substantia nigra. These studies not only offer promise for treating Parkinson's disease, but also provide insights into properties of the nigrostriatal system that may eventually help to prevent neuronal degeneration.
Fisher
L J
LJ
Salk Institute, Laboratory of Genetics, San Diego, CA 92186-5800, USA.
Gage
F H
FH
D000311:Adrenal Glands / Q000637:transplantation; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D016380:Brain Tissue Transplantation; D017690:Cell Transplantation; D016332:Fetal Tissue Transplantation; D015316:Genetic Therapy; D006801:Humans; D009410:Nerve Degeneration / Q000517:prevention & control; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*