[Selenium administration in patients with sepsis syndrome. A prospective randomized study].
METHODS
In this study the effect of antioxidative therapy with sodium selenite was investigated in patients with systemic inflammatory response syndrome (S. I. R. S.) and multiple organ failure. 40 patients were included in this prospective randomized study. The patients were observed over a period of 28 days. The letality rate within 28 days was excepted as main criteria. The Apache-II and the MOF-Score of Goris were used as clinical parameters. 20 patients were treated with sodium selenite over a period of 28 days.


RESULTS
This antioxidative therapy reduced the letality rate from 40 to 15%.
Zimmermann
T
T
Klinik für Viszeral-, Thorax- und Gefässchirurgie, Universitätsklinikums Carl Gustav Carus der TU Dresden.
Albrecht
S
S
Kühne
H
H
Vogelsang
U
U
Grützmann
R
R
Kopprasch
S
S
D000975:Antioxidants / Q000008:administration & dosage*; D006801:Humans; D009102:Multiple Organ Failure / Q000188:drug therapy* / Q000401:mortality; D011446:Prospective Studies; D018038:Sodium Selenite / Q000008:administration & dosage*; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy* / Q000401:mortality
D000975:Antioxidants; D018038:Sodium Selenite