[Contents of general, bound and free cortisol in sheep blood during different periods of acute radiation sickness].
The hypothalamic-hypophyseal-cortical multifetal sheep system reaction was examined to respond the sharp single action X-rays dosed 0.96 and 3.84 Gr. The primary irradiation answer was accompanied by expressed hypercorticoidism, which essentially increased with irradiation dose rising and followed the induction of CRF-hypothalamic activity. The secondary sheep hypercorticoidism preceded the clinico-hematomancy and depended on irradiation dose. Hypercorticoidism-2 resulted in blood free bioactive cortisol content increasing. The compensative decrease of named system activity favoured to beam illness outcome. It the prognosis was poor the free and reached its peek before animal death. These data can be used as a test for beam illness outcome prognosis.
Belov
A D
AD
Lysenko
N P
NP
D000208:Acute Disease; D000308:Adrenocortical Hyperfunction / Q000209:etiology; D000818:Animals; D006854:Hydrocortisone / Q000097:blood* / Q000378:metabolism; D011379:Prognosis; D011485:Protein Binding; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000401:mortality; D011863:Radioimmunoassay; D012756:Sheep; D013997:Time Factors
D006854:Hydrocortisone