[p16 and p53 genes transferred with the help of adenovirus to induce apoptic tumor cell death].
Based on studies of the cell cycle in tissue cultures of cancer cell lines and cells from normal tissue interference in the regulatory network of pRB/cdk4/cyclin D1/p16 in combination with the tumour suppressor gene p53 was investigated. It was shown that overexpression of p53 and p16, but not p53 on its own, induced apoptotic cell death only in tumour cells. Gene transfer of the same two genes to tumours transplanted subcutaneously in mice also caused fast regression of some of the tumours.
Sandig
B V
BV
Max-Planck-Gesellschaft, Berlin.
Brand
K
K
Herwig
S
S
Lukas
J
J
Bartek
J
J
Strauss
M
M
D000260:Adenoviruses, Human / Q000235:genetics; D000818:Animals; D017209:Apoptosis; D018014:Gene Transfer Techniques; D019942:Genes, p16; D016158:Genes, p53; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured