Mitotane (o,p'-DDD) treatment in a cat with hyperadrenocorticism.
An 11-year-old male castrated Persian cat with spontaneous hyperadrenocorticism was presented. Both adrenals were grossly enlarged and calcified. A diagnosis of pituitary-dependent hyperadrenocorticism was made. Signs of hyperadrenocorticism resolved with long-term mitotane treatment. Concurrent diabetes mellitus resolved after 220 days of therapy. No severe adverse drug reactions were noted.
Schwedes
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CS
Tierärztliche Klinik Dr Unger, Augsburg, Germany.
D000302:Adrenal Cortex / Q000000981:diagnostic imaging / Q000473:pathology; D000308:Adrenocortical Hyperfunction / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D002371:Cat Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008939:Mitotane / Q000627:therapeutic use*; D011859:Radiography; D013997:Time Factors; D014463:Ultrasonography
D018931:Antineoplastic Agents, Hormonal; D001786:Blood Glucose; D007328:Insulin; D008939:Mitotane; D006854:Hydrocortisone