title: [Imidazole derivatives, platelet aggregation inhibitors].
abstract: Study of the platelet aggregation inhibition has shown the efficiency of compounds with imidazole ring alone or fused. All the compounds resulting of the molecular design starting from these structures has an in vitro activity. We have been able to discuss the correlation existing between activities, toxicities and structures with a particular emphasis to the lipophilicity.
authors.affiliation: Académie de Technologie Chimique Fine Lomonossove, Moscou, Russie.
authors.forename: N
authors.initials: N
authors.lastname: Sergueeva
authors.forename: R
authors.initials: R
authors.lastname: Evstigueeva
authors.forename: M
authors.initials: M
authors.lastname: Rivière
authors.forename: A
authors.initials: A
authors.lastname: Lattes
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D014560:Urocanic Acid / Q000031:analogs & derivatives; D014970:Xanthines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001562:Benzimidazoles; D007093:Imidazoles; D010975:Platelet Aggregation Inhibitors; D014970:Xanthines; D014560:Urocanic Acid