Anti-atherosclerotic properties of nifedipine. Benefit of early intervention to prevent cardiovascular complications.
Early stages of the atherosclerotic plaque are considered to be responsible for about 2/3 of all acute coronary syndromes. Therefore, suppression of this initial stage of plaque formation constitutes a major target to reduce the incidence of the disease itself as well as its complications. Ca antagonists, like Nifedipine, interfere with Ca++ ions crucially involved in atherogenesis. Consequently, interval angiographic trials with Nifedipine in patients afflicted with coronary artery disease assessed a significant reduction of coronary lesions. Clinical outcome trials will establish the prognostic importance of the anti-atherosclerotic properties of Nifedipine.
Rafflenbeul
W
W
Hannover Medical School, Germany.
D000208:Acute Disease; D000818:Animals; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000517:prevention & control*; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000517:prevention & control*; D003331:Coronary Vessels / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009543:Nifedipine / Q000627:therapeutic use*; D011379:Prognosis
D002121:Calcium Channel Blockers; D009543:Nifedipine; D002118:Calcium