Acylation stimulating protein and the adipocyte.
ASP constitutes a metabolic bridge integrating events in the circulation with the adipocyte microenvironment and regulation of a key adipose function-storage of fat. Dysregulation of the ASP pathway may have important metabolic consequences and may be associated with both obesity on one hand and cardiovascular disease on the other hand. Clearly, many in vitro and in vivo studies remain to be done to establish clearly such links and future work on ASP promises to be both exciting and rewarding.
Cianflone
K
K
McGill Unit for the Prevention of Cardiovascular Disease, McGill University, Montreal, Quebec, Canada.
D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism*; D015926:Complement C3a / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000378:metabolism*; D015398:Signal Transduction; D014280:Triglycerides / Q000378:metabolism
D001798:Blood Proteins; D014280:Triglycerides; C044541:complement C3a, des-Arg-(77)-; D015926:Complement C3a; D005947:Glucose