title: T cells selectively infiltrate bone marrow areas with residual haemopoiesis of patients with acquired aplastic anaemia.
abstract: Aplastic anaemia (AA) is characterized by pancytopenia and bone marrow (BM) hypocellularity. In some patients AA may be mediated by T cells. To localize inflammatory cell infiltrates, we carried out a quantitative immunohistochemical analysis of BM biopsies of AA patients. In five out of eight biopsies, significantly higher numbers T cells were found in the areas with residual haemopoiesis (RH). The significantly increased numbers of CD3+ T cells in areas with RH supports the hypothesis of a site-directed infiltration and/or a local proliferation of T cells in the BM of patients with AA.
authors.affiliation: Department of Haematology, Leiden University Medical Centre, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Melenhorst
authors.forename: J H
authors.initials: JH
authors.lastname: van Krieken
authors.forename: E
authors.initials: E
authors.lastname: Dreef
authors.forename: J E
authors.initials: JE
authors.lastname: Landegent
authors.forename: R
authors.initials: R
authors.lastname: Willemze
authors.forename: W E
authors.initials: WE
authors.lastname: Fibbe
mesh_terms: D000741:Anemia, Aplastic / Q000473:pathology*; D001854:Bone Marrow Cells / Q000473:pathology; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000502:physiology*