Effects of lecithinized SOD on contusion injury in rats.
To analyze the effect of lecithinized superoxide dismutase (SOD) on superoxide accumulation after traumatic injury, the expression of Cu,Zn-SOD mRNA was examined after contusion in rat using Northern blotting. As determined by specific gravity, lecithinized SOD decreased brain edema. The expression of Cu,Zn-SOD mRNA increased at the core, peripheral and contralateral hemisphere of injury. These increases were then suppressed by lecithinized SOD. Our results support the hypothesis that superoxide may play an important role in edema formation after contusion, and that lecithinized SOD appears to prevent brain edema through a protective effect against superoxide injury.
Yunoki
M
M
Department of Neurological Surgery, Okayama University Medical School, Japan.
Noguchi
Y
Y
Nishio
S
S
Ono
Y
Y
Kawauchi
M
M
Asai
S
S
Ohmoto
T
T
Asanuma
M
M
Ogawa
N
N
D000818:Animals; D001924:Brain Concussion / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D008297:Male; D010713:Phosphatidylcholines / Q000737:chemistry*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013046:Specific Gravity; D013482:Superoxide Dismutase / Q000737:chemistry / Q000235:genetics*
D010713:Phosphatidylcholines; D012333:RNA, Messenger; D013482:Superoxide Dismutase