title: Heparin-induced extracorporeal fibrinogen/LDL precipitation (HELP): a promising regimen for the treatment of vascular diseases.
abstract: Current management of atherosclerotic diseases consists primarily of medical therapy designed to increase oxygen supply to the heart, the brain, retinal vessels, or lower limbs. The development of these diseases is based on atherosclerotic changes induced by risk factors such as elevated levels of fibrinogen and lipoproteins. These risk factors are related to a dramatic deterioration of the hemorrheologic pattern, which reduces perfusion. Consequently, attempts are now being made to treat ischemia via hemorrheological intervention. A new treatment modality utilizing the heparin-induced extracorporeal low-density lipoprotein (LDL) precipitation (HELP), offers the possibility of obtaining therapeutic success not only in cases of severe hypercholesterolemia but also in the field of hemorheology. With HELP a safe and rapid reduction of fibrinogen and lipid fractions has become feasible, thus providing acute improvements of red cell aggregation, of the filterability of blood cells, of whole-blood and plasma viscosity, and thereby of microcirculation. Because cerebrovascular diseases are known to be related to disturbances of the hemorrheological situation, the HELP system is used in the Department of Electrobiology of Graz for the treatment of acute stroke, cerebral multi-infarct disease, and occlusions of retinal arteries.
authors.affiliation: Department of Electrobiology, HELP Center, General Hospital, University Departments of Graz, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Walzl
authors.forename: B
authors.initials: B
authors.lastname: Walzl
authors.forename: A
authors.initials: A
authors.lastname: Haas
mesh_terms: D000208:Acute Disease; D002561:Cerebrovascular Disorders / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D005112:Extracorporeal Circulation / Q000295:instrumentation / Q000379:methods*; D005260:Female; D005340:Fibrinogen / Q000032:analysis / Q000302:isolation & purification*; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005590:Fractional Precipitation; D006438:Hemodilution; D018056:Hemorheology; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000302:isolation & purification*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D018917:Optic Neuropathy, Ischemic / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D011446:Prospective Studies; D013923:Thromboembolism / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D005343:Fibrinolytic Agents; D008077:Lipoproteins, LDL; D005340:Fibrinogen; D006493:Heparin