title: Application of the bivariate spectrophotometric method for the determination of metronidazole, furazolidone and di-iodohydroxyquinoline in pharmaceutical formulations.
abstract: The bivariate calibration algorithm was applied to the spectrophotometric determination of metronidazole, furazolidone and di-iodohydroxyquinoline in pharmaceutical dosage forms. The results obtained were compared with the results of derivative spectrophotometry. The statistical evaluation of method bias was carried out, and it was shown that the proposed procedure may be competitive with commonly used first-derivative spectrophotometry. The advantage of the bivariate calibration is its simplicity, and the fact that there is no need to use the derivatization procedures.
authors.affiliation: Instituto de Investigaciones Científicas, Universidad de Guanajuato, Mexico. lopezp@quijote.ugto.mx
authors.forename: P L
authors.initials: PL
authors.lastname: López-de-Alba
authors.forename: K
authors.initials: K
authors.lastname: Wróbel
authors.forename: L
authors.initials: L
authors.lastname: López-Martínez
authors.forename: K
authors.initials: K
authors.lastname: Wróbel
authors.forename: M L
authors.initials: ML
authors.lastname: Yepez-Murrieta
authors.forename: J
authors.initials: J
authors.lastname: Amador-Hernández
mesh_terms: D000563:Amebicides / Q000032:analysis*; D000994:Antitrichomonal Agents / Q000032:analysis*; D005664:Furazolidone / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D004103:Iodoquinol / Q000032:analysis*; D008795:Metronidazole / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis; D013053:Spectrophotometry / Q000379:methods*; D013057:Spectrum Analysis
chemical_list: D000563:Amebicides; D000994:Antitrichomonal Agents; D004364:Pharmaceutical Preparations; D008795:Metronidazole; D005664:Furazolidone; D004103:Iodoquinol