Oxygen-free radicals directly attack the ATP binding site of the cardiac Na+,K(+)-ATPase.
Xu
K Y
KY
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA. kxu@welchlink.welch.jhu.edu
Zweier
J L
JL
Becker
L C
LC
D000227:Adenine Nucleotides / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000494:pharmacology*; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012508:Sarcolemma / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013395:Sucrose / Q000494:pharmacology
D000227:Adenine Nucleotides; D017665:Hydroxyl Radical; D013395:Sucrose; D000255:Adenosine Triphosphate; D006861:Hydrogen Peroxide; D000254:Sodium-Potassium-Exchanging ATPase