Plasma levels of monocyte chemoattractant protein-1 but not those of macrophage inhibitory protein-1alpha and RANTES correlate with virus load in human immunodeficiency virus infection.
Plasma levels of proinflammatory cytokines, cytokine inhibitors, and the beta chemokines RANTES, macrophage inhibitory protein (MIP)-1alpha, and monocyte chemoattractant protein (MCP)-1 were studied in relationship with virus load in 40 patients exhibiting plasma levels of HIV RNA ranging between undetectable and levels >10(6) copies/mL. Mean plasma levels of MCP-1 were increased in patients with high virus load compared with HIV-seropositive subjects with undetectable plasma viral RNA and healthy controls. MCP-1 levels were directly correlated with plasma levels of HIV RNA. No correlation was observed between virus load and plasma concentrations of MIP-1alpha and RANTES. The results suggest that low rates of viral replication in vivo are not dependent on increased production of the suppressive chemokines RANTES and MIP-1alpha. Since MCP-1 upregulates viral replication in vitro, the results may suggest a role for MCP-1 in triggering viral replication in HIV disease.
Weiss
L
L
INSERM U430 and Université Pierre et Marie Curie, Hôpital Broussais, Paris, France.
Si-Mohamed
A
A
Giral
P
P
Castiel
P
P
Ledur
A
A
Blondin
C
C
Kazatchkine
M D
MD
Haeffner-Cavaillon
N
N
D018932:Chemokine CCL2 / Q000097:blood*; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000097:blood*; D016207:Cytokines / Q000097:blood; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000821:virology*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D018950:Lipopolysaccharide Receptors / Q000097:blood; D019402:Macrophage Inflammatory Proteins / Q000097:blood*; D012367:RNA, Viral / Q000097:blood; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D012795:Sialoglycoproteins / Q000097:blood; D019562:Viral Load; D014779:Virus Replication
D018932:Chemokine CCL2; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D016207:Cytokines; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D018950:Lipopolysaccharide Receptors; D019402:Macrophage Inflammatory Proteins; D012367:RNA, Viral; D017472:Receptors, Interleukin-1; D018124:Receptors, Tumor Necrosis Factor; D012795:Sialoglycoproteins