Modulation of growth factor action: implications for the treatment of cardiovascular diseases.
Peptide growth factors are involved in fundamental cellular processes relevant for cardiovascular physiology and pathology, namely, atherogenesis and angiogenesis. The modulation of growth factor-related signals represents a novel strategy for the treatment of cardiac and vascular disease. Experimental modulation of growth factor action has already provided a better understanding of cardiovascular biology and pathophysiology. In turn, the development of specific and powerful molecular tools is setting the stage for the exploration of their clinical potentials. Current strategies include the use of recombinant proteins, specific inhibitors of protein-protein interactions, tyrosine kinase inhibitors, the generation and application of dominant-negative molecules, the development of antisense strategies, and a variety of different gene transfer approaches. Parallel avenues of research are heading toward the same goal, the specific suppression of potent pathogenic stimuli that induce and promote atherogenesis or the augmentation of beneficial ones such as induction of therapeutic angiogenesis. The successful application of one of these strategies seems to be in reach and will certainly be a milestone in molecular medicine.
Waltenberger
J
J
Department of Internal Medicine II (Cardiology), Ulm University Medical Center, Germany. johannes.waltenberger@medizin.uni-ulm.de
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology / Q000628:therapy; D002318:Cardiovascular Diseases / Q000503:physiopathology* / Q000628:therapy*; D003097:Collateral Circulation; D016228:Endothelial Growth Factors / Q000502:physiology; D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D006131:Growth Inhibitors / Q000627:therapeutic use; D006133:Growth Substances / Q000819:agonists / Q000502:physiology*; D006801:Humans; D008222:Lymphokines / Q000502:physiology; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy; D018919:Neovascularization, Physiologic; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D017539:Tunica Intima; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D006131:Growth Inhibitors; D006133:Growth Substances; D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2