title: Association of Leishmania heat shock protein 83 antigen and immunoglobulin G4 antibody titers in Brazilian patients with diffuse cutaneous leishmaniasis.
abstract: Diffuse cutaneous leishmaniasis (DCL) is characterized by the presence of numerous nonulcerated nodules and plaques containing large numbers of Leishmania amazonensis parasites and few lymphoid elements. The immune responses of DCL patients reflect severe antigen-specific T-cell deficiencies, while the antibody response to Leishmania antigens is often accentuated. We report herein on the Leishmania antigen-specific antibody subclass distribution in DCL patients and demonstrate that a dominant antigen contributing to the biased immunoglobulin G4 antibody subclass in sera of DCL patients is Leishmania heat shock protein 83.
authors.affiliation: Corixa Corporation, Seattle, Washington 98104, USA. Skeiky@Corixa.Com
authors.forename: Y A
authors.initials: YA
authors.lastname: Skeiky
authors.forename: D R
authors.initials: DR
authors.lastname: Benson
authors.forename: J L
authors.initials: JL
authors.lastname: Costa
authors.forename: R
authors.initials: R
authors.lastname: Badaro
authors.forename: S G
authors.initials: SG
authors.lastname: Reed
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology*; D001938:Brazil / Q000453:epidemiology; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007891:Leishmania / Q000276:immunology*; D016774:Leishmaniasis, Diffuse Cutaneous / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D006360:Heat-Shock Proteins; C490310:Hsp83 protein, protozoan; D007074:Immunoglobulin G; D015800:Protozoan Proteins