[Diagnosis of fetal akinesia except for oligoamnios].
The term Fetal Akinesia Sequence (FAS) covers a large spectrum of developmental abnormalities resulting from a lack of intra-uterine fetal movements, which share heterogeneous etiologies. Environmental, "extrinsic" causes are easily ruled out. Various neuromuscular disorders, involving the motor unit at any level, constitute the main part of "intrinsic" fetal pathology. We propose a detailed schedule of prospective investigation of FAS, in order to standardize and gather the most pertinent information and to compare a wide panel of accurate data between fetopathological centers. The objective is to improve the understanding of various pathogenetic processes involved in the emergence of FAS, in order to propose better information and genetic counselling to parents, and potentially, to consider a prenatal prevention.
Fallet-Bianco
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C
Unité de foetopathologie, Laboratoire de Biologie du Développement, Hôpital Robert-Debré, Paris.
D002986:Clinical Trials as Topic; D005324:Fetal Movement / Q000502:physiology*; D006801:Humans; D009069:Movement Disorders / Q000175:diagnosis*; D016104:Oligohydramnios / Q000175:diagnosis; D011296:Prenatal Diagnosis; D011446:Prospective Studies