Molecular characterization of the Salmonella typhi StpA protein that is related to both Yersinia YopE cytotoxin and YopH tyrosine phosphatase.
Analysis of the nucleotide sequence of a 4-kb DNA fragment located between the sip and iag loci on Salmonella typhi chromosome revealed three open reading frames, termed sipF, ctpA and stpA. The 82-amino-acid (aa) sipF product showed extensive similarity to the lacP protein from S. typhimurium. The StpA protein (535 aa) exhibited significant similarity to both Yersinia enterocolitica YopE cytotoxin and YopH tyrosine phosphatase. The CtpA polypeptide (130 aa) might be the molecular chaperone of the StpA protein.
Arricau
N
N
Unité de Génétique des Bactéries intracellulaires, Unité INSERM 389, Institut Pasteur, Paris, France.
Hermant
D
D
Waxin
H
H
Popoff
M Y
MY
D001426:Bacterial Proteins / Q000648:ultrastructure*; D001483:Base Sequence; D003603:Cytotoxins / Q000737:chemistry*; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry*; D012485:Salmonella typhi / Q000235:genetics* / Q000472:pathogenicity; D012486:Salmonella typhimurium / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014774:Virulence; D015008:Yersinia enterocolitica / Q000201:enzymology / Q000378:metabolism*
D001426:Bacterial Proteins; D003603:Cytotoxins; D018832:Molecular Chaperones; D017027:Protein Tyrosine Phosphatases