title: Toenail onychomycosis in patients with acquired immune deficiency syndrome: treatment with terbinafine.
abstract: Skin infections caused by dermatophytes are one of the most frequent dermatological complications in patients with acquired immunodeficiency syndrome (AIDS) resulting from infection with human immunodeficiency virus (HIV). Tinea unguium associated with AIDS is characterized by being clinically more aggressive and therapeutically more difficult to treat than in the general population. Terbinafine is considered to be a first-choice option for the treatment of dermatophyte onychomycosis in immunocompetent individuals. This drug has been used in a series of 21 HIV-positive patients diagnosed with tinea unguium for 1 year in the University Hospital La Paz, Madrid. All patients underwent a subsequent clinical follow-up for 6 months. The results showed a high percentage of clinical and mycological cures, as well as maintenance of the response after follow-up; no drug interactions or significant adverse effects related to the drug under study were recorded.
authors.affiliation: Department of Dermatology, La Paz University Hospital, Autónoma University, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Herranz
authors.forename: J
authors.initials: J
authors.lastname: García
authors.forename: R
authors.initials: R
authors.lastname: De Lucas
authors.forename: J
authors.initials: J
authors.lastname: González
authors.forename: J M
authors.initials: JM
authors.lastname: Peña
authors.forename: R
authors.initials: R
authors.lastname: Díaz
authors.forename: M
authors.initials: M
authors.lastname: Casado
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use*; D014009:Onychomycosis / Q000188:drug therapy* / Q000473:pathology; D000077291:Terbinafine; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine