title: Splenic lymphoma with villus lymphocytes--an uncommon cause for lymphocytosis.
abstract: We describe the clinical and laboratory features of four patients who presented with mild to moderate lymphocytosis but with no peripheral lymphadenopathy. These patients in the past, would have been classified as chronic lymphocytic leukaemia (CLL). However, it is now realised that chronic lymphoproliferative disorders are very heterogeneous and the clinical and laboratory features of our patients would support a diagnosis of splenic lymphoma with villus lymphocytes (SLVL) with characteristic morphological features. SLVL usually runs a benign clinical course but symptoms related a benign clinical course but symptoms related to splenomegaly or hypersplenism may be a problem. Splenectomy is considered the treatment of choice in these patients. Two of our patients had splenectomy and the other two patients are on regular follow-up without any specific treatment. It is therefore important to recognise this uncommon condition and also to differentiate it from CLL.
authors.affiliation: Haematology Division, National University Hospital, Singapore.
authors.forename: P
authors.initials: P
authors.lastname: Kuperan
authors.forename: C P
authors.initials: CP
authors.lastname: Teo
authors.forename: S M
authors.initials: SM
authors.lastname: Chong
authors.forename: T C
authors.initials: TC
authors.lastname: Liu
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008218:Lymphocytosis / Q000209:etiology*; D008223:Lymphoma / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000150:complications* / Q000473:pathology; D013163:Splenomegaly / Q000209:etiology