[Abnormal endometrial reactivity to colony stimulating factor 1 and leukemia inhibitory factor dependent female infertility].
Maternal LIF is essential for embryo implantation in mice and it may also be the case in humans. We recently reported that endometrial LIF secretion from infertile women presenting repeated failures of embryonic implantation or unexplained sterility was significantly lower than the secretion of explants from fertile women. We now report on the modulation of the endometrial LIF secretion according to the obstetrical status. CSF-1 has little effect or increases LIF secretion from fertile women whereas it inhibits secretion from infertile women with repeated failures of embryonic implantation.
Laprée-Delage
G
G
Laboratoire de Biologie cellulaire et moléculaire de la relation materno-foetale, INSERM CJF 92-09/DRED JE 370, Bâtiment de Gynécologie-Obstétrique, Hôpital Antoine-Béclère, Clamart.
Moreau
J F
JF
Taupin
J L
JL
Kadhel
P
P
Olivennes
F
F
Hambartsoumian
E
E
Frydman
R
R
Tartakovsky
B
B
Chaouat
G
G
D000328:Adult; D000818:Animals; D016022:Case-Control Studies; D010064:Embryo Implantation / Q000502:physiology; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006131:Growth Inhibitors / Q000378:metabolism*; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology*; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000378:metabolism*; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology*; D051379:Mice; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome
D006131:Growth Inhibitors; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse; D008222:Lymphokines; D016173:Macrophage Colony-Stimulating Factor