title: End-stage cystic fibrosis: improved diabetes control 2 years after successful isolated pancreatic cell and double-lung transplantation.
abstract: Over a period of years, insulin-dependent diabetes and respiratory insufficiency developed in a 35-year-old patient with end-stage cystic fibrosis. After waiting more than 4 years while receiving maintenance treatment with continuous liquid O2 and nasal ventilation, the patient underwent double-lung and pancreatic islet cell transplantation. Subsequently, the patient has enjoyed a normal life with full employment and much better control of his diabetes. Pancreatic islet cell transplantation is a simple and innocuous technique easily added to the end of lung transplantation. These new pancreatic cells, although locally injected, are still secreting more than 2 years later as assessed by repeated C-peptide measurements.
authors.affiliation: Centre Valaisan de Pneumologie, Montana, Switzerland.
authors.forename: J M
authors.initials: JM
authors.lastname: Tschopp
authors.forename: M H
authors.initials: MH
authors.lastname: Brutsche
authors.forename: J G
authors.initials: JG
authors.lastname: Frey
authors.forename: A
authors.initials: A
authors.lastname: Spiliopoulos
authors.forename: L
authors.initials: L
authors.lastname: Nicod
authors.forename: T
authors.initials: T
authors.lastname: Rochat
authors.forename: P
authors.initials: P
authors.lastname: Morel
mesh_terms: D000208:Acute Disease; D000328:Adult; D003131:Combined Modality Therapy; D003550:Cystic Fibrosis / Q000601:surgery*; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D016381:Islets of Langerhans Transplantation; D016040:Lung Transplantation; D008297:Male; D012074:Remission Induction; D012131:Respiratory Insufficiency / Q000601:surgery; D013997:Time Factors