title: Experimentally induced pruritus and cutaneous reactions with topical antihistamine and local analgesics in atopic eczema.
abstract: We investigated the antipruritic effect of a 15-min application of dimethindene maleate (Fenistil gel) and other local analgesics (Optiderm, EMLA, Xylocain ointment 5%) on subsequent focal histamine stimulus (20 mC) given by iontophoresis in 12 patients suffering from acute atopic eczema (AE). The results were compared to histamine after pretreatment with the respective placebo and to non-pretreated skin. Wheal and flare areas were planimetrically evaluated. Itch or pain ratings were performed over a 24-min period using a rating scale. The examination also comprised alloknesis, i.e. induction of a perifocal itch sensation by a non-itching mechanical stimulus. None of the antihistaminic and anaesthetic agents reduced the itch intensity significantly. Three of the AE patients had a total lack of alloknesis. We conclude that these substances, when applied for 15 min, are not sufficiently effective in atopic skin suppressing histamine-induced reactions under experimental conditions. The diminished elicitation of alloknesis in these patients may be a result of central nervous system alteration.
authors.affiliation: Department of Dermatology, University Erlangen-Nuremberg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Weisshaar
authors.forename: C
authors.initials: C
authors.lastname: Forster
authors.forename: M
authors.initials: M
authors.lastname: Dotzer
authors.forename: G
authors.initials: G
authors.lastname: Heyer
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D019162:Anesthetics, Combined / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000627:therapeutic use*; D000982:Antipruritics / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000150:complications / Q000188:drug therapy*; D004115:Dimethindene / Q000627:therapeutic use; D005260:Female; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology
chemical_list: D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D000982:Antipruritics; D006634:Histamine H1 Antagonists; D004115:Dimethindene; D006632:Histamine