title: Prognostic significance of Ki-67 expression in transitional cell bladder carcinoma after radical cystectomy.
abstract: We evaluated the prognostic significance of the Ki-67 labeling index (Ki-67 LI) in 75 patients with transitional cell carcinoma of the bladder who underwent radical cystectomy. Immunohistochemical staining of archival material was performed by the streptavidin-biotin method. Univariate survival analysis showed that Ki-67 LI (p < 0.001), histologic grade (p < 0.05), tumor stage (p < 0.001) and the number of positive lymph nodes (p < 0.001) significantly correlated with prognosis. Multivariate survival analysis indicated that the Ki-67 LI (p < 0.05), histologic grade (p < 0.01), tumor stage (p < 0.01), presence of lymph node metastases (p < 0.05) and use of neo-adjuvant therapy (p < 0.05) had independent prognostic value. The Ki-67 LI is an independent prognostic factor for patients with transitional cell bladder cancer treated by radical cystectomy.
authors.affiliation: Department of Urology, Yokohama City University School of Medicine, Kanagawa-ken, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suwa
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: M
authors.initials: M
authors.lastname: Iki
authors.forename: T
authors.initials: T
authors.lastname: Asakura
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: M
authors.initials: M
authors.lastname: Masuda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D015653:Cystectomy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000601:surgery
chemical_list: D019394:Ki-67 Antigen