title: Diabetes insipidus from sarcoidosis confined to the posterior pituitary.
abstract: A young white man with new-onset central diabetes insipidus was discovered to have a posterior pituitary mass on magnetic resonance imaging. No other radiological abnormalities were noted in the anterior pituitary, infundibulum or hypothalamus. No other endocrinopathies were present: laboratory investigations showed normal basal concentrations of anterior pituitary hormones, including prolactin. The patient was suspected to have sarcoidosis affecting the posterior pituitary, because of the discovery of pulmonary sarcoidosis during his diagnostic evaluation. His symptoms of polydipsia and polyuria responded promptly to intranasal administration of 1-desamino-8-D-arginine vasopressin (DDAVP). The patient demonstrated complete regression of the posterior pituitary mass after a course of corticosteroid therapy. However, his diabetes insipidus persisted and he continues to need DDAVP treatment, currently at 12 months of follow-up. The resolution of the neurohypophysial mass was compatible with the diagnosis of pituitary sarcoidosis and this precluded the need for a transsphenoidal biopsy or surgery.
authors.affiliation: Department of Medicine, University of California-San Francisco, USA.
authors.forename: K C
authors.initials: KC
authors.lastname: Loh
authors.forename: A
authors.initials: A
authors.lastname: Green
authors.forename: W P
authors.initials: WP
authors.lastname: Dillon
authors.forename: P A
authors.initials: PA
authors.lastname: Fitzgerald
authors.forename: N
authors.initials: N
authors.lastname: Weidner
authors.forename: J B
authors.initials: JB
authors.lastname: Tyrrell
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010900:Pituitary Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D010904:Pituitary Gland, Posterior; D013902:Radiography, Thoracic; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D003894:Deamino Arginine Vasopressin