title: Relationship between endocrine, immune, and clinical variables in patients with systemic lupus erythematosus.
abstract: OBJECTIVE
  To assess the frequency of increased plasma prolactin (PRL) in patients with systemic lupus erythematosus (SLE) and to evaluate its relationship to other hormonal and immune variables.
  
  
  METHODS
  Thirty-five patients with SLE with various levels of disease activity were studied. Plasma PRL, cortisol, growth hormone (GH) were determined by radioimmunoassay and interleukin 6 (IL-6) by ELISA: SLE activity was evaluated using the European Consensus Lupus Activity Measurement (ECLAM).
  
  
  RESULTS
  Increased plasma PRL concentration (> 20 ng/ml) was recorded in 11 patients (31%). No correlation was found between plasma PRL and GH, IL-6, cortisol, or C-reactive protein, nor was any significant correlation observed between plasma PRL and the ECLAM score. Patients with hyperprolactinemia were, however, found to have been treated with higher doses of prednisone therapy than patients with normal plasma PRL. Further analysis of the relationship of plasma PRL and therapy showed that patients with SLE selected by the attending physician for prednisone therapy in doses > or = 10 mg/day were more frequently hyperprolactinemic.
  
  
  CONCLUSIONS
  Our findings that patients with SLE with a more active form of the disease and who are less responsive to therapy had increased plasma PRL levels more frequently may be indicative of a potential relationship of hyperprolactinemia to severity of disease.
authors.affiliation: Research Institute of Rheumatic Diseases, Piest'any, Slovakia.
authors.forename: J
authors.initials: J
authors.lastname: Rovenský
authors.forename: E
authors.initials: E
authors.lastname: Juránková
authors.forename: L
authors.initials: L
authors.lastname: Rauová
authors.forename: S
authors.initials: S
authors.lastname: Blazícková
authors.forename: J
authors.initials: J
authors.lastname: Lukác
authors.forename: Z
authors.initials: Z
authors.lastname: Veselková
authors.forename: D
authors.initials: D
authors.lastname: Jezová
authors.forename: M
authors.initials: M
authors.lastname: Vigas
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D004703:Endocrine System / Q000503:physiopathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006966:Hyperprolactinemia / Q000503:physiopathology*; D015850:Interleukin-6 / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D000974:Antibodies, Antinuclear; D005938:Glucocorticoids; D015850:Interleukin-6; D002097:C-Reactive Protein; D006854:Hydrocortisone