[Biological effects of acute external or internal irradiation of rats in the framework of nitrite intoxication].
The material presented provides evidence that high nitrite doses have a various effect under the condition of external or internal radiation. Thus, nitrite protector properties were observed in male rats exposed to external radiation using the LD50/30 while following 90Sr exposure male rats of the same age showed a higher sensitivity to the radionuclide. The nitrite combined with optimum carcinogenic 90Sr dose had a potentiating effect on both life-span shortening and increase in osteosarcoma rate in the animals.
Shvedov
V L
VL
Korytnyĭ
V S
VS
Krupitskaia
L I
LI
Anisimova
G G
GG
Priakhin
E A
EA
Tolstykh
E I
EI
D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009573:Nitrites / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D012516:Osteosarcoma / Q000209:etiology*; D011833:Radiation Injuries, Experimental / Q000401:mortality; D011837:Radiation-Protective Agents; D051381:Rats; D013326:Strontium Radioisotopes / Q000008:administration & dosage
D009573:Nitrites; D011837:Radiation-Protective Agents; D013326:Strontium Radioisotopes