In vivo NMR and MRI using injection delivery of laser-polarized xenon.
Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo 129Xe NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.
Goodson
B M
BM
Lawrence Berkeley National Laboratory and University of California, Berkeley, CA 94720, USA.
Song
Y
Y
Taylor
R E
RE
Schepkin
V D
VD
Brennan
K M
KM
Chingas
G C
GC
Budinger
T F
TF
Navon
G
G
Pines
A
A
D006801:Humans; D007834:Lasers; D008168:Lung / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011859:Radiography; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes