Ventilatory responses and subjective sensations during arm exercise and hypercapnia in patients with lower-cervical and upper-thoracic spinal cord injuries.
We measured the ventilatory responses and subjective sensations during arm exercise in patients with lower cervical and upper thoracic spinal cord injuries in order to evaluate the effects of chest wall deafferentation on these responses. Visual analog scales with verbal descriptors were used to quantify respiratory sensations of different affectional qualities. Patients as well as normal subjects reported stronger respiratory sensations upon CO2 rebreathing as compared to during arm exercise with an equivalent minute ventilation (p<0.05). There were no qualitative nor quantitative differences in the respiratory sensations during CO2 rebreathing between the patients and normal subjects. However, patients with spinal cord injuries showed a higher minute ventilation and a lower end-tidal PCO2 during incremental arm exercises (p<0.01), and thus tended to hyperventilate. We conclude that chest wall afferent denervation does not contribute significantly to the perception of breathlessness in patients with spinal cord injuries.
Oku
Y
Y
Department of Clinical Physiology, Chest Disease Research Institute, Kyoto University, Shogoin.
Kurusu
M
M
Hara
Y
Y
Sugita
M
M
Muro
S
S
Chin
K
K
Mishima
M
M
Ohi
M
M
Kuno
K
K
D000328:Adult; D002574:Cervical Vertebrae / Q000293:injuries*; D004417:Dyspnea / Q000150:complications / Q000503:physiopathology / Q000534:rehabilitation; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006935:Hypercapnia / Q000209:etiology / Q000503:physiopathology* / Q000534:rehabilitation; D011237:Predictive Value of Tests; D012119:Respiration / Q000502:physiology*; D012129:Respiratory Function Tests; D012677:Sensation / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology* / Q000534:rehabilitation; D013904:Thoracic Vertebrae / Q000293:injuries*