Susceptibility to leprosy is linked to the human NRAMP1 gene.
Leprosy is a debilitating infectious disease of human skin and nerves. Genetic factors of the host play an important role in the manifestation of disease susceptibility. The human NRAMP1 gene is a leprosy susceptibility candidate locus since its murine homologue Nramp1 (formerly Lsh/Ity/Bcg) controls innate resistance to Mycobacterium lepraemurium. In this study, 168 members of 20 multiplex leprosy families were genotyped for NRAMP1 alleles and 4 closely linked polymorphic markers. Highly informative haplotypes overlapping the NRAMP1 gene were constructed, and the haplotype segregation into leprosy-affected offspring was analyzed. It was observed that the segregation of NRAMP1 haplotypes into affected siblings was significantly nonrandom. This finding is consistent with the hypothesis that NRAMP1 itself is a leprosy susceptibility locus.
Abel
L
L
INSERM Unité 436, Hôpital-Pitié Salpêtrière, Paris, France.
Sánchez
F O
FO
Oberti
J
J
Thuc
N V
NV
Hoa
L V
LV
Lap
V D
VD
Skamene
E
E
Lagrange
P H
PH
Schurr
E
E
D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D027682:Cation Transport Proteins; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006790:Host-Parasite Interactions / Q000235:genetics; D006801:Humans; D007918:Leprosy / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D000099173:Natural Resistance-associated Macrophage Protein 1
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D005819:Genetic Markers; D008565:Membrane Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1