title: cDNA cloning of the translocon associated protein beta-subunit in the chick cerebellum.
abstract: The 'translocon associated protein' is a tetrameric complex residing in the translocation sites, in which nascent polypeptides pass through the endoplasmic reticulum membrane. The beta subunit of this complex is a single spanning membrane protein, as deduced from cDNAs deriving from canine or human epithelial tissues. We have isolated and analysed a cDNA clone of the beta subunit from chick nervous tissue, namely cerebellum. Its deduced protein sequence is 91% homologous to both the canine and the human protein sequences, showing that the molecule is highly conserved.
authors.affiliation: Department of Biology, Medical Faculty, University of Patras, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Zarkadis
authors.forename: E
authors.initials: E
authors.lastname: Vezyri
authors.forename: E
authors.initials: E
authors.lastname: Kouvelas
authors.forename: D
authors.initials: D
authors.lastname: Thanos
authors.forename: J
authors.initials: J
authors.lastname: Papamatheakis
authors.forename: A
authors.initials: A
authors.lastname: Athanassiadou
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002531:Cerebellum / Q000378:metabolism*; D002645:Chickens; D003001:Cloning, Molecular; D018076:DNA, Complementary; D004285:Dogs; D006801:Humans; D008562:Membrane Glycoproteins; D008969:Molecular Sequence Data; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D018000:Receptors, Peptide / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D002135:Calcium-Binding Proteins; D018076:DNA, Complementary; D008562:Membrane Glycoproteins; D018160:Receptors, Cytoplasmic and Nuclear; D018000:Receptors, Peptide; C066973:signal sequence receptor