Amino acid sequence homology of factor C produced by Streptomyces griseus with regulatory proteins of zinc finger type.
Factor C is a regulatory protein produced by Streptomyces griseus 45H. Factor C-like antigen can be detected in the most diverse species examined. It is also present in human serum with an average of 219.4 U/ml of narrow dispersion. The level of factor C-like antigen shows an increase in the sera of patients with different hepatic disorders (341 U/ml), some values being 3-7 times higher than normal (600-1500 U/ml). Correlation was found between the elevated antigen levels and the amount of the bilirubin in the sera of patients with liver cirrhosis. Amino acid sequence homology was found between factor C and zinc finger motifs of several known DNA binding proteins. In fact, factor C was successfully bound to and eluted from a Zn2+ affinity column. Our data show that factor C is probably a zinc finger type DNA binding protein.
Szeszák
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Institute of Biology, University Medical School, Debrecen, Hungary.
Vitális
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Biró
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Dalmi
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D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial / Q000097:blood / Q000235:genetics; D001426:Bacterial Proteins / Q000097:blood / Q000235:genetics* / Q000276:immunology; D017124:Conserved Sequence; D019143:Evolution, Molecular; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000382:microbiology; D017386:Sequence Homology, Amino Acid; D013305:Streptomyces griseus / Q000235:genetics* / Q000276:immunology; D016335:Zinc Fingers / Q000235:genetics* / Q000276:immunology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins