title: Parkinsonism associated with acute intracranial hematomas: an [18F]dopa positron-emission tomography study.
abstract: We present the case of a 36-year-old woman with a right temporal hematoma and an overlying subdural hematoma following rupture of a right middle cerebral artery aneurysm. Three weeks after recovering consciousness, she developed a levodopa-responsive parkinsonian syndrome involving the right limbs. A year after the vascular event, she reported subjective improvement in her parkinsonism, which has remained stable since. 18F-dopa positron-emission tomography showed a marked reduction of uptake in the left putamen, raising the possibility that the intracranial hemorrhage unmasked latent Parkinson's disease. To the best of our knowledge, this is the first case of parkinsonism associated with spontaneous acute intracerebral and subdural hematomas.
authors.affiliation: MRC Cyclotron Unit, Hammersmith Hospital, London, England, U.K.
authors.forename: N
authors.initials: N
authors.lastname: Turjanski
authors.forename: B
authors.initials: B
authors.lastname: Pentland
authors.forename: A J
authors.initials: AJ
authors.lastname: Lees
authors.forename: D J
authors.initials: DJ
authors.lastname: Brooks
mesh_terms: D000208:Acute Disease; D000328:Adult; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D003342:Corpus Striatum / Q000000981:diagnostic imaging; D005260:Female; D005462:Fluorine Radioisotopes; D006406:Hematoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D010302:Parkinson Disease, Secondary / Q000150:complications* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011859:Radiography; D014055:Tomography, Emission-Computed
chemical_list: D000978:Antiparkinson Agents; D005462:Fluorine Radioisotopes; D007980:Levodopa