title: Peyronie's disease: intralesional treatment with interferon alpha-2A and evaluation of the results by magnetic resonance imaging.
abstract: In this clinical study, to determine the therapeutic efficacy of interferon (IFN) treatment for Peyronie's disease, we applied interferon alpha-2A (IFN alpha-2A) intralesionally in the treatment of Peyronie plaques in 15 patients and results were evaluated by magnetic resonance imaging (MRI). Patients whose plaque sizes were 0.5 and 1 cm responded better to the treatment. There was about a 90% lessening in the sizes of the plaques of 1.5 cm, 83.3% of 2 cm, as the ones which were 0.5 cm and 1 cm disappeared completely after treatment. As a conclusion, the treatment of Peyronie's disease with IFN alpha-2A is effective and side effects are minimum.
authors.affiliation: Department of Urology, Atatürk University School of Medicine, Erzurum, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Polat
authors.forename: O
authors.initials: O
authors.lastname: Gül
authors.forename: I
authors.initials: I
authors.lastname: Ozbey
authors.forename: M
authors.initials: M
authors.lastname: Ozdikici
authors.forename: Y
authors.initials: Y
authors.lastname: Bayraktar
mesh_terms: D000328:Adult; D006801:Humans; D015552:Injections, Intralesional; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000175:diagnosis / Q000188:drug therapy*; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins