Sensory conduction study of cisplatin neuropathy: preservation of small myelinated fibers.
We report a patient with peripheral neuropathy caused by cisplatin for the treatment of testicular tumor. Routine studies of nerve conduction and somatosensory evoked potentials demonstrated large myelinated fiber neuropathy suggesting ganglioneuronopathy. We also performed a CO2 laser evoked potential study, and found that small myelinated fibers, which are related to pain sensation, were well preserved in this patient.
Yamamoto
M
M
Department of Neurology, Chubu National Hospital, Aichi.
Kachi
T
T
Yamada
T
T
Nagamatsu
M
M
Sobue
G
G
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory; D005727:Ganglia, Spinal / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000187:drug effects* / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects* / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D013736:Testicular Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D002945:Cisplatin