title: The study of correlation structures of DNA sequences: a critical review.
abstract: The study of correlation structure in the primary sequences of DNA is reviewed. The issues reviewed include: symmetries among 16 base-base correlation functions; accurate estimation of correlation measures; the relationship between 1/f and Lorentzian spectra; heterogeneity in DNA sequences; different modeling strategies of the correlation structure of DNA sequences; the difference of correlation structure between coding and non-coding regions (besides the period-3 pattern); and source of broad distribution of domain sizes. Although some of the results remain controversial, a body of work on this topic constitutes a good starting point for future studies.
authors.affiliation: Laboratory of Statistical Genetics, Rockefeller University, New York, NY 10021, USA. wli@linkage.rockefeller.edu
authors.forename: W
authors.initials: W
authors.lastname: Li
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D005821:Genetic Techniques; D008962:Models, Theoretical; D011336:Probability; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004247:DNA