The effects of glucocorticoids and a glucocorticoid antagonist (RU 38486) on experimental acute pancreatitis in rat.
The effects of glucocorticoids on acute pancreatitis are a matter of dispute. In animal experiments, dexamethasone and hydrocortisone significantly decreased the serum amylase activities 8 hours after the induction of pancreatitis. In the dexamethasone treated group, the serum IL-6 level was significantly decreased at 4 and 8 hours, while in the hydrocortisone treated group, all the IL-6 values were significantly diminished vs. the control group. As compared to the control, a glucocorticoid antagonist (RU 38486) did not influence the serum amylase activity, but significantly increased the serum IL-6 level. These results suggest that glucocorticoids may play a role in the control of pancreatitis caused by inhibition of cytokine production.
Lázár
G
G
Department of Surgery, Albert Szent-Györgyi Medical University, Hungary.
Varga
J
J
Lázár
G
G
Duda
E
E
Takács
T
T
Balogh
A
A
Lonovics
J
J
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D003907:Dexamethasone / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D005938:Glucocorticoids / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D015850:Interleukin-6 / Q000097:blood; D015735:Mifepristone / Q000627:therapeutic use*; D010195:Pancreatitis / Q000188:drug therapy*; D051381:Rats; D013997:Time Factors; D000093242:Interleukin-6 Inhibitors
D000681:Amylases; D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D005938:Glucocorticoids; D006727:Hormone Antagonists; D006854:Hydrocortisone; D015850:Interleukin-6; D015735:Mifepristone; D000093242:Interleukin-6 Inhibitors