TGF-beta 1 and IL-6--new aspects in pancreas regeneration?
Plasma levels of interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta 1) were studied during cholecystokinin octapeptide (CCK-8)-induced regeneration after pancreas resection in rats. The weight of the pancreas and the DNA and protein contents increased significantly. The serum levels of TGF-beta 1 and IL-6 were increased significantly on days 7 and 14. There was no significant change in serum amylase levels. These findings indicate that cytokines such as TGF-beta 1 and IL-6 may play a role in the pathomechanism of pancreas regeneration.
Farkas
G
G
Department of Surgery, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Takács
T
T
Mándi
Y
Y
Balogh
A
A
D000681:Amylases / Q000097:blood; D000818:Animals; D004247:DNA / Q000032:analysis; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology; D007279:Injections, Subcutaneous; D015850:Interleukin-6 / Q000097:blood / Q000502:physiology*; D008297:Male; D009929:Organ Size; D010179:Pancreas / Q000737:chemistry / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D010180:Pancreatectomy; D011506:Proteins / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000097:blood / Q000502:physiology*
D005765:Gastrointestinal Agents; D015850:Interleukin-6; D011506:Proteins; D016212:Transforming Growth Factor beta; D004247:DNA; D000681:Amylases; D012844:Sincalide