title: In vitro activity of biapenem against recent gram-negative and gram-positive clinical isolates.
abstract: The in vitro activity of biapenem, a new carbapenem, against 535 clinical recent isolates was compared with those of other antibiotics. Biapenem showed broad-spectrum activity against gram-negative and gram-positive clinical isolates. The new carbapenem was more active than imipenem against members of the family Enterobacteriaceae with MIC90S ranging from 0.12 to 2 mg/l and from 0.25 to 4 mg/l, respectively. Moreover it was 2-fold more active than imipenem against Pseudomonas aeruginosa (MIC90, 8 and 16 mg/l, respectively). Taken together, these results indicate that biapenem shares the favorable in vitro activity properties of imipenem and merits further study in the treatment of infections caused by a wide range of pathogens.
authors.affiliation: Institute of Microbiology, University of Catania, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bonfiglio
authors.forename: G
authors.initials: G
authors.lastname: Maccarone
authors.forename: M L
authors.initials: ML
authors.lastname: Mezzatesta
authors.forename: A
authors.initials: A
authors.lastname: Privitera
authors.forename: V
authors.initials: V
authors.lastname: Carciotto
authors.forename: M
authors.initials: M
authors.lastname: Santagati
authors.forename: S
authors.initials: S
authors.lastname: Stefani
authors.forename: G
authors.initials: G
authors.lastname: Nicoletti
mesh_terms: D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D013845:Thienamycins; C065257:biapenem