Derivatives of 2-mercaptobenzenesulphonamide. XX. Synthesis and cardiovascular effects of some 2-[4-chloro-2-(2-dialkylaminoethylthio)-5-methylbenzenesulphonylimino]- perhydropyrimidines.
A series of 2-[4-chloro-2-(2-dialkylaminoethylthio)-5-methyl- benzenesulphonylimino]perhydropyrimidines [IV-X] and their hydrochlorides [IVa-VIIIa] were prepared. The antiarrhythmic effect of the most active compound [Va] was comparable to the reference drugs, quinidine and procainamide. The influence of the tested compounds [IVa, Va, VIa] on the blood pressure and heart rate of rats as well as the acute toxicity in mice were studied.
Pomarnacka
E
E
Department of Chemical Drug Technology, Medical University of Gdańsk, Poland.
Oledzka
K
K
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D002317:Cardiovascular Agents / Q000138:chemical synthesis*; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D002317:Cardiovascular Agents; D013438:Sulfhydryl Compounds; D013449:Sulfonamides