title: Time versus density enhancement of liver, spleen, and great vessels following rapid intravenous infusion of perflubron emulsion.
abstract: OBJECTIVE
  We studied hepatosplenic enhancement in rhesus monkeys for 5 hr after rapid administration of perflubron (perfluorooctyl bromide [PFOB]) in an attempt to determine a clinically useful imaging window.
  
  
  METHODS
  Five rhesus monkeys were examined using perflubron emulsion, 90% w/v perfluorochemical administered intravenously at a dose of 1.5 ml/kg and rate of 0.5 ml/sec. Helical computed tomography examination of the abdomen was obtained prior to the contrast bolus and 5 min, 30 min, 1, 2, 3, 4, and 5 hr postcontrast. Mean density of liver, spleen, and aorta was measured at each time interval.
  
  
  RESULTS
  Significant aortic enhancement of 53 +/- 7 Hounsfield units (HU) (p < .0001) and liver enhancement of 19 +/- 4 H (p < .0004) occurred after 5 min and did not change significantly (p > .05) over 5 hr. Splenic enhancement of 35 +/- 9 HU was significant at 5 min (p < .0001) and continued to increase for 5 hr.
  
  
  CONCLUSIONS
  Enhancement of the liver, blood vessels, and spleen is rapid and persists for at least 5 hr, which suggests a wider temporal window for hepatosplenic imaging with perflubron than is currently available with iodinated contrast agents.
authors.affiliation: Department of Radiology, Egleston Children's Hospital, Emory University, Atlanta, GA 30322, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Harned
authors.forename: S A
authors.initials: SA
authors.lastname: Fruman
authors.forename: R B
authors.initials: RB
authors.lastname: Swenson
authors.forename: M E
authors.initials: ME
authors.lastname: Bernardino
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000008:administration & dosage*; D004655:Emulsions / Q000008:administration & dosage; D005466:Fluorocarbons / Q000008:administration & dosage*; D006842:Hydrocarbons, Brominated; D007262:Infusions, Intravenous; D008099:Liver / Q000000981:diagnostic imaging*; D008253:Macaca mulatta; D013154:Spleen / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron