Innervation of two peptidergic (substance P and calcitonin gene-related peptide) nerves in the cerebral arteries and choroid plexus of the Japanese Newt (Triturus pyrrhogaster).
The pattern of cerebrovascular substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactive (-IR) innervation was investigated in the newt. SP-IR nerves supplying the cerebral arterial tree and choroid plexus were positive for CGRP, but negative for vasoactive intestinal polypeptide or neuropeptide Y. It is suggested that cerebrovascular SP- and CGRP-IR axons are sensory in nature. The supply of SP- and CGRP-IR nerves to the major cerebral arteries is relatively poor. Nevertheless, numerous SP- and CGRP-IR axons, which are contained in the fiber bundles on the cerebral carotid artery and the basilar artery, spread widely over the microvascular-epithelial regions of the choroid plexuses. It must be considered in relation to the significant role of SP- and CGRP-IR neuronal mechanisms responsible to the microcirculation, cerebrospinal fluid (CSF) production and transport action within the choroid plexus in the nutrition of the newt brain via the CSF.
Ando
K
K
Department of Regional Culture, Faculty of International Studies of Culture, Kyushu Sangyo University, Fukuoka, Japan.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D001488:Basilar Artery / Q000294:innervation; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D002536:Cerebral Arteries / Q000294:innervation*; D002831:Choroid Plexus / Q000166:cytology*; D007150:Immunohistochemistry; D009412:Nerve Fibers / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology*; D013373:Substance P / Q000032:analysis*; D014319:Triturus
D013373:Substance P; D015740:Calcitonin Gene-Related Peptide