title: Statistical evaluation of hearing screening by distortion product otoacoustic emissions.
abstract: The aim of this study was to provide a statistical evaluation of the screening properties of distortion product otoacoustic emissions (DPOEs) in individuals with clinically normal hearing and in patients with pure sensorineural deafness of various degrees. The main informational parameters used were sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the analysis of receiver operating characteristic (ROC) curves. For each frequency tested, ears were classified as a function of their audiometric threshold. Two groups were defined relative to an arbitrary reference, the "audiometric criterion." The PPV decreased and NPV increased with increases in the audiometric criterion. Each point of the ROC curve represents the relationship between the false alarm rate and the hit rate for each audiometric criterion ranging between 10 and 75 dB hearing level: the lower the audiometric criterion, the lower the hit rate value, and the lower the false alarm value. The audiometric criterion giving the highest hit rate and the lowest false alarm rate was 55 to 60 dB hearing level for primaries at 60 and 70 dB sound pressure level, or 25 to 30 dB hearing level for primaries at 30, 40, and 50 dB sound pressure level. These two different behaviors of ROC curves are consistent with the hypothesis that DPOEs do not represent activity at a single location along the basilar membrane.
authors.affiliation: Auditory Research Laboratory (CNRS UMR Neurobiologie des Systemes Sensorimoteurs) and Formation Associée Claude Bernard, Hospital Boucicaut, and Faculté Necker-Enfants Malades, Université René Descartes, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Bonfils
authors.forename: P
authors.initials: P
authors.lastname: Avan
authors.forename: P
authors.initials: P
authors.lastname: Landais
authors.forename: M
authors.initials: M
authors.lastname: Erminy
authors.forename: B
authors.initials: B
authors.lastname: Biacabe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001299:Audiometry / Q000592:standards*; D015982:Bias; D016022:Case-Control Studies; D003662:Decision Theory; D016002:Discriminant Analysis; D006319:Hearing Loss, Sensorineural / Q000145:classification / Q000503:physiopathology* / Q000517:prevention & control*; D006801:Humans; D008403:Mass Screening / Q000592:standards*; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity