Persistent cortical blindness after cyclosporine leukoencephalopathy.
Cyclosporine A (CyA)-related cortical blindness is an uncommon complication of CyA therapy in patients undergoing liver transplantation. Characteristically, neurological symptoms associated with CyA treatment usually regress after cyclosporine withdrawal. We present a case of a liver transplant recipient in whom discontinuation of CyA therapy has resulted in only partial clinical improvement, and cortical blindness remains after 1 year of follow-up. The evolution of cerebral magnetic resonance imaging (MRI) findings over time in this form of CyA leukoencephalopathy is also described.
Casanova
B
B
Neurology Service, Hospital Universitari La Fe, València, Spain.
Prieto
M
M
Deya
E
E
Gisbert
C
C
Mir
J
J
Berenguer
J
J
Vilchez
J J
JJ
D019575:Blindness, Cortical / Q000139:chemically induced*; D001927:Brain Diseases / Q000139:chemically induced*; D016572:Cyclosporine / Q000009:adverse effects*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D017093:Liver Failure / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced*; D013997:Time Factors
D007166:Immunosuppressive Agents; D016572:Cyclosporine