title: Cerebrospinal fluid loss and threshold changes. 2. Electrocochleographic changes of the compound action potential after CSF aspiration: an experimental study.
abstract: Hearing loss has been reported following leakage of cerebrospinal fluid (CSF). The etiology has been attributed to an induced imbalance in the intracochlear hydrodynamics. The present study reports a guinea pig model with surgically induced loss of CSF. In 18 anesthetized animals, CSF was drained by a suboccipital incision in the dura: Eighteen animals were used as controls. The compound action potentials were recorded by an ear canal silver electrode. The animals with CSF loss showed a small increase in threshold and latency, while the control group was unchanged. The concept of an induced inner ear fluid dysfunction after CSF leak is supported by these findings.
authors.affiliation: Department of Audiology, Bispebjerg University Hospital, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Walsted
authors.forename: P
authors.initials: P
authors.lastname: Nilsson
authors.forename: J
authors.initials: J
authors.lastname: Gerlif
mesh_terms: D000818:Animals; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006168:Guinea Pigs; D010498:Perilymph / Q000502:physiology; D012016:Reference Values