A vaccine against the Asian schistosome, Schistosoma japonicum: an update on paramyosin as a target of protective immunity.
Paramyosin from parasitic worms of the genus Schistosoma has shown promise as a vaccine target and it is one of the candidates selected by WHO for the development of a vaccine against schistosomiasis. Here we discuss the literature of the past decade and report on different recombinant paramyosin constructs we are using in our laboratory to develop a vaccine against the Asian schistosoma, Schistosoma japonicum.
Kalinna
B H
BH
Molecular Parasitology Unit, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, Bancroft Centre, Royal Brisbane Hospital, Australia. berndK@qimr.edu.au
McManus
D P
DP
D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth / Q000235:genetics; D015801:Helminth Proteins / Q000235:genetics / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D012549:Schistosoma japonicum / Q000235:genetics / Q000276:immunology*; D012554:Schistosomiasis japonica / Q000276:immunology / Q000517:prevention & control*; D014335:Tropomyosin / Q000235:genetics / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000302:isolation & purification*
D000947:Antigens, Helminth; D015801:Helminth Proteins; D011994:Recombinant Proteins; D014335:Tropomyosin; D014614:Vaccines, Synthetic