Effect of magnetic resonance exposure combined with gadopentetate dimeglumine on chromosomes in animal specimens.
OBJECTIVE
We tested for the presence of a form of unstable chromosomal damage--anaphase bridges--that might result from the combined exposure to gadopentetate dimeglumine and magnetic resonance (MR) imaging in rats.


METHODS
Fifty-four male Sprague-Dawley rats, along with appropriate controls, were exposed either to MR imaging alone, gadopentetate dimeglumine alone, or a combination of the two. After exposure, partial hepatectomies were performed to induce a vigorous mitotic response in the regenerating liver stump. Twenty-eight to 30 hr after partial hepatectomy, tissue specimens from regenerating liver were removed and analyzed microscopically for the presence of anaphase bridges.


RESULTS
No anaphase bridges were detected in any of the animals, including those exposed to gadopentetate dimeglumine and MR imaging.


CONCLUSIONS
Using anaphase bridge formation as an indicator, exposure to MR imaging alone, gadopentetate dimeglumine alone, or a combination of the two under the conditions used in this experiment did not cause detectable unstable chromosomal damage.
Rofsky
N M
NM
Department of Radiology, New York University Medical Center, New York 10016, USA.
Pizzarello
D J
DJ
Duhaney
M O
MO
Falick
A K
AK
Prendergast
N
N
Weinreb
J C
JC
D000705:Anaphase / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D000818:Animals; D002452:Cell Count / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects* / Q000528:radiation effects*; D003287:Contrast Media / Q000009:adverse effects*; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D019786:Gadolinium DTPA / Q000009:adverse effects*; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects / Q000528:radiation effects; D008115:Liver Regeneration / Q000187:drug effects / Q000528:radiation effects; D008279:Magnetic Resonance Imaging / Q000009:adverse effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012449:Safety
D003287:Contrast Media; D019786:Gadolinium DTPA