[Lysogenic conversion as a factor influencing tolerance to vancomycin in Staphylococcus aureus].
The standard, non-lysogenic, bacteriophage-free S. aureus NCTC 8325-4 strain was lysogenized with 15 different, obtained in our laboratory staphylokinase-converting bacteriophages belonging to serological groups A, B and F. MIC and MBC of vancomycin as well as the ratio of MBC to MIC were evaluated for all 15 lysogenic derivatives. The obtained results were compared with those for maternal strain. In the case of eight strains the ratio MBC/MIC showed the presence of tolerance to vancomycin (MBC/MIC > or = 32). Four of the vancomycin-tolerant derivatives were lysogenized with bacteriophages belonging to the serological group A, two were members of group B and two belonged to group F.
Młynarczyk
G
G
Zakład Bakteriologii Klinicznej AM w Warszawie.
Młynarczyk
A
A
Zabicka
D
D
Jeljaszewicz
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001434:Bacteriophage Typing; D004352:Drug Resistance, Microbial; D008242:Lysogeny; D008826:Microbial Sensitivity Tests; D013204:Staphylococcus Phages / Q000145:classification*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014640:Vancomycin