title: [Pulmonary reaction after furazidin (Furagin). Case report].
abstract: For the first time in Poland we present the case of pulmonary reaction to furazidin which is by chemical structure closely related to nitrofurantoin. 63 years old woman presented generalized symptoms of acute hypersensitivity reaction induced by furazidin as well as features of chronic pulmonary fibrosis. After few months of treatment with this drug patients complained of weight loss, dyspnea on effort, non-productive cough, chills and fever. Radiological and functional evaluation of respiratory system confirmed features of lung fibrosis. Drug provocation test was positive. In vitro furazidin in low concentrations stimulated proliferation of patient's lymphocytes. After cessation of treatment we have observed rapid improvement of clinical, radiological, biochemical and functional parameters.
authors.affiliation: I Klinika Gruzlicy i Chorób Płuc, Warszawie.
authors.forename: T M
authors.initials: TM
authors.lastname: Zielonka
authors.forename: U
authors.initials: U
authors.lastname: Demkow
authors.forename: J
authors.initials: J
authors.lastname: Kuś
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D005260:Female; D005661:Furagin / Q000009:adverse effects*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis; D011859:Radiography; D012129:Respiratory Function Tests; D012130:Respiratory Hypersensitivity / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000892:Anti-Infective Agents, Urinary; D005661:Furagin