Characteristics of mutagenesis by bleomycin and adriamycin in Salmonella typhimurium: action of catalase.
The influence of catalase activity in adriamycin and bleomycin mutagenesis was investigated in Salmonella typhimurium TA98 and TA102, respectively. The activity of catalase in bacterial cells was inhibited by sodium azide. Mutagenicity of both drugs was not changed in bacterial cells with depressed catalase activity.
Ejchart
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Drug Institute, Warsaw, Poland.
Chłopkiewicz
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B
D001761:Bleomycin / Q000633:toxicity*; D002374:Catalase / Q000494:pharmacology*; D004317:Doxorubicin / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D009153:Mutagens; D001761:Bleomycin; D004317:Doxorubicin; D002374:Catalase