title: Remission of myasthenia gravis caused by proteinuria in nephrotic syndrome.
abstract: Myasthenia gravis is caused by antibodies against acetylcholine receptors and is treated with inhibition or elimination of antibody production. We report a 43-year-old myasthenic female who was symptomatic until she developed proteinuria from nephrotic syndrome, which caused a marked drop in acetylcholine receptor antibody titer with remission of myasthenia. Treatment of the nephrotic syndrome produced exacerbation of her myasthenia and a rise in antibody level. This patient's improvement is the result of antibody elimination during proteinuria in nephrotic syndrome.
authors.affiliation: Department of Neurology, University of Tennessee Memphis, 38163, USA.
authors.forename: M
authors.initials: M
authors.lastname: Almsaddi
authors.forename: T E
authors.initials: TE
authors.lastname: Bertorini
authors.forename: W
authors.initials: W
authors.lastname: Bastnagel
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000150:complications* / Q000276:immunology / Q000503:physiopathology*; D009404:Nephrotic Syndrome / Q000150:complications* / Q000652:urine*; D011507:Proteinuria / Q000209:etiology* / Q000503:physiopathology*; D011950:Receptors, Cholinergic / Q000276:immunology; D012075:Remission, Spontaneous
chemical_list: D000906:Antibodies; D011950:Receptors, Cholinergic