[Biological preparation based on Lactobacillus acidophilus, a new agent in the early treatment of combined radiation-thermal injuries].
Male mice F1 (CBA x C57BL6) were used for experiments. Animals were exposed to 7 Gy gamma-radiation and additionally inflicted to full-thickness thermal burn 10% body surface. As it has been revealed, single subcutaneous injection of the created biopreparation based on inactivated lactobacillus microbic biomass increased mice survival with combined injury from 23% to 73%. Therapeutic efficacy of this remedy did not correlate with postradiation damages of the hemopoietic system. Injection of killed L. acidophilus mixture strikingly averted development of the intestine autoinfection. Possible mechanisms of the benefit therapeutic action of the new preparation are discussed.
Budagov
R S
RS
Ul'ianova
L P
LP
Pospelova
V V
VV
Khanina
G I
GI
Rakhimova
N G
NG
Makarov
G F
GF
D000818:Animals; D001688:Biological Products; D002056:Burns / Q000150:complications / Q000401:mortality / Q000628:therapy*; D007779:Lactobacillus acidophilus; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000401:mortality / Q000628:therapy*; D013997:Time Factors
D001688:Biological Products