Presence of human immunodeficiency virus (HIV) type 1 subtype A infection in a New York community with high HIV prevalence: a sentinel site for monitoring HIV genetic diversity in North America. Centers for Disease Control and Prevention-Bronx Lebanon HIV Serosurvey Team.
To determine whether US residents are infected with subtypes of human immunodeficiency virus (HIV) type 1 other than subtype B (Western), the predominant North American subtype with a unique GPGR genetic sequence in the V3 loop, viruses from 22 HIV-infected adults were serotyped and subtyped. Twenty patients had subtype B (Western), of whom 15 had serotype B (Western), 3 had serotype A/C, 1 had serotype B (Thai), and 1 had a nontypeable serotype. Two had subtype A, both serotype A/C. Both subtype A-infected patients, only 1 of whom had been outside the United States, reported sex with persons traveling abroad, suggesting possible acquisition in the United States. Because US residents are infected with non-subtype B (Western) strains, US surveillance for HIV-1 diversity is needed to elucidate subtype-specific transmission patterns and pathogenesis and to guide evaluation and development of HIV diagnostic tests and vaccines.
Irwin
K L
KL
Centers for Disease Control and Prevention, and Orkland Corporation Atlanta, GA 30333, USA.
Pau
C P
CP
Lupo
D
D
Pienazek
D
D
Luo
C C
CC
Olivo
N
N
Rayfield
M
M
Hu
D J
DJ
Weber
J T
JT
Respess
R A
RA
Janssen
R
R
Minor
P
P
Ernst
J
J
D000293:Adolescent; D000328:Adult; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008297:Male; D017720:Molecular Epidemiology; D009518:New York / Q000453:epidemiology; D009656:North America / Q000453:epidemiology; D010446:Peptide Fragments / Q000235:genetics; D010802:Phylogeny; D018571:Sentinel Surveillance; D016036:Seroepidemiologic Studies; D012703:Serotyping
D004279:DNA, Viral; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments