[The role of free-radical lipid oxidation in the pathogenesis of chronic prostatitis].
The study of antioxidant activity (AOA), levels of molecular products of free-radical oxidation and ceruloplasmin in secretion of the prostate and blood plasma in 30 healthy males and 90 patients with chronic prostatitis has revealed multidirectional shifts in AOA, prostatic secretion and ceruloplasmin plasma levels in patients with chronic prostatitis. Parallel shifts in AOA and ceruloplasmin correspond to the view on ceruloplasmin as leading antioxidant in blood plasma. High ceruloplasmin concentrations in chronic prostatitis may be considered as compensatory-adaptive response aimed at compensation of local ceruloplasmin deficiency and AOA in the inflamed prostatic tissue. Artificial rise of ceruloplasmin content in the blood flow reduced clinical and laboratory signs of chronic prostatitis.
Volchegorskiĭ
I A
IA
Tarasov
N I
NI
Seregin
S P
SP
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D002908:Chronic Disease; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism; D011472:Prostatitis / Q000209:etiology* / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D002570:Ceruloplasmin