Malignancy in Peutz-Jeghers syndrome? The pitfall of pseudo-invasion.
Peutz-Jeghers syndrome is a malignancy-associated polyposis syndrome. We describe a histopathologic phenomenon easily encountered when examining the nature of Peutz-Jeghers polyps but that is underreported in the literature. This phenomenon of "pseudo-invasion" may mimic invasive carcinoma due to epithelial displacement and erroneously give the impression, both macroscopically and microscopically, that a malignancy is involved. This potential pitfall is illustrated by the case of a patient with Peutz-Jeghers syndrome who was thought to harbor a metastasizing adenocarcinoma in his small bowel with peritoneal metastasis as a perioperative finding. Histologic examination, however, revealed pseudo-invasion.
Westerman
A M
AM
Department of Internal Medicine, Erasmus University, Rotterdam, The Netherlands.
van Velthuysen
M L
ML
Bac
D J
DJ
Schouten
W R
WR
Wilson
J H
JH
D000328:Adult; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology*; D010375:Pedigree; D010580:Peutz-Jeghers Syndrome / Q000473:pathology*