Comparative physiological features of the regulatory effect of vasopressin on higher nervous activity in an ascending series of mammals.
This report provides comparative physiological data on the features of the regulatory effects of the neurohormone vasopressin on higher nervous activity in an ascending series of mammals consisting of insectivores, rodents, and primates. Administration of vasopressin to hedgehogs produced a general facilitatory effect on conditioned reflex brain activity. The effects of vasopressin on memory processes in hedgehogs was minor. In rabbits, vasopressin had greater regulatory effects on conditioned reflex memory than in hedgehogs. However, this was transient in nature. In monkeys, administration of vasopressin had complex differential effects on simple conditioned responses and different types of memory. The effects of vasopressin on memory processes were long-lasting and were different for corticalized and noncorticalized forms of nervous activity. The question of changes in the nature of the regulatory effects of vasopressin during phylogenesis is discussed, as is the question of the increases in its level of involvement in the regulation of higher nervous functions and memory processes.
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Laboratory for the Comparative Physiology of the Cerebellum, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology / Q000502:physiology*; D003216:Conditioning, Operant / Q000502:physiology; D004569:Electroencephalography; D000882:Haplorhini; D006364:Hedgehogs; D006613:Higher Nervous Activity / Q000502:physiology*; D008568:Memory / Q000502:physiology; D010802:Phylogeny; D011817:Rabbits
D001127:Arginine Vasopressin