Propofol for sedation in the intensive care unit: essentials for the clinician.
Propofol is a short-acting intravenous anesthetic commonly utilised in the intensive care unit (ICU) for sedation of mechanically ventilated patients. The rapid onset and termination of action make it an attractive drug for use in the ICU. The safety profile of propofol is well established. However, there are potential adverse reactions associated with the drug. This review discusses the pharmacology, administration and adverse effects associated with propofol with which clinicians who administer propofol should be familiar.
Marinella
M A
MA
Department of Internal Medicine, Wright State University School of Medicine, Dayton, OH, USA.
D000328:Adult; D000368:Aged; D001049:Apnea / Q000139:chemically induced; D001919:Bradycardia / Q000139:chemically induced; D003422:Critical Care; D004334:Drug Administration Schedule; D006207:Half-Life; D006801:Humans; D006991:Hypnosis, Anesthetic; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D007022:Hypotension / Q000139:chemically induced; D008657:Metabolic Clearance Rate; D010146:Pain / Q000139:chemically induced; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology
D006993:Hypnotics and Sedatives; D015742:Propofol