title: Assignment of human plasma methylumbelliferyl-tetra-N-acetylchitotetraoside hydrolase or chitinase to chromosome 1q by a linkage study.
abstract: Plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase or chitinase (CHIT) might play a role in degrading the chitin wall of some microorganisms. In about 6% of Caucasian people the enzyme shows pseudodeficiency (defined as very low activity without apparent symptoms). We have mapped this locus by linkage analysis to the marker D1S306 (z = 4.00 at theta M = F = 0.0) on chromosome 1q between the flanking markers D1S191 and D1S245 in the area of 1q31-1qter.
authors.affiliation: Panum Institute, Center for Human Genetics, Copenhagen, Denmark. he@rclink.imbg.ku.dk
authors.forename: H
authors.initials: H
authors.lastname: Eiberg
authors.forename: W R
authors.initials: WR
authors.lastname: Den Tandt
mesh_terms: D001798:Blood Proteins / Q000235:genetics*; D002688:Chitinases / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006596:Hexosaminidases / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree
chemical_list: D001798:Blood Proteins; C057702:4-methylumbelliferyl-tetra-N-acetyl-beta-D-chitotetraoside hydrolase; D006596:Hexosaminidases; D002688:Chitinases