title: Pituitary apoplexy of a gonadotroph adenoma following gonadotrophin releasing hormone agonist therapy for prostatic cancer.
abstract: Treatment of prostatic cancer with GnRH agonist is a medical alternative to surgical castration, although hyperstimulation of the tumor can occur. We describe an unusual unwanted effect of such a treatment which unmasked a clinically silent gonadotroph adenoma. A 62-year-old man developed after the first injection of leuprorelin-depot a sudden intracranial hypertension, which was related to apoplexy of an unknown pituitary adenoma. Its gonadotroph origin was recognized after surgery by immunocytochemistry. Retrospectively, the tumor was shown to secrete in vivo both FSH and LH when on therapy with the agonist, demonstrating the lack of desensitization. Testosterone levels were also markedly and sustainly high when on therapy, a particularly unwanted effect in prostatic cancer. As gonadotroph adenomas occur in men in the same age group as prostatic cancer, the question is raised whether hormonal testing and pituitary imaging should be performed before starting a therapy with GnRH agonist in men.
authors.affiliation: Department of Endocrinology, University of Caen, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Reznik
authors.forename: F
authors.initials: F
authors.lastname: Chapon
authors.forename: N
authors.initials: N
authors.lastname: Lahlou
authors.forename: N
authors.initials: N
authors.lastname: Deboucher
authors.forename: J
authors.initials: J
authors.lastname: Mahoudeau
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D003692:Delayed-Action Preparations; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D016729:Leuprolide / Q000009:adverse effects* / Q000627:therapeutic use; D007986:Luteinizing Hormone / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D010899:Pituitary Apoplexy / Q000139:chemically induced*; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D011471:Prostatic Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D013739:Testosterone / Q000097:blood
chemical_list: D003692:Delayed-Action Preparations; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide