title: Aseptic spondylitis as the initial manifestation of the SAPHO syndrome.
abstract: We describe the case of a 61-year-old female patient who presented with spondylitis of the lumbar spine. Although the microbiological cultures of the bone biopsy specimens obtained during laminotomy remained negative, the patient was treated with broad-spectrum antimicrobials for 2 months. Eight months later she started to suffer from pain and tenderness in her sternum and the medial portion of her left clavicle. The findings of computed tomography and gallium-labelled isotope scan were indicative of sternoclavicular arthritis. Again, all surgically obtained biopsy specimens yielded negative results in microbiological studies. The diagnosis of the SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteomyelitis) syndrome was then made based on the clinical presentation with recurrent sterile osteitis in two characteristic locations, and the patient was started on immunosuppressive therapy. This case is a reminder that SAPHO may sometimes occur without any skin manifestations. Since this type of patient may be admitted to an orthopedic ward, it is important that orthopedic surgeons are familiar with the syndrome.
authors.affiliation: Department of Medicine, Turku University Central Hospital, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Kotilainen
authors.forename: R E
authors.initials: RE
authors.lastname: Gullichsen
authors.forename: R
authors.initials: R
authors.lastname: Saario
authors.forename: I
authors.initials: I
authors.lastname: Manner
authors.forename: E
authors.initials: E
authors.lastname: Kotilainen
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis* / Q000188:drug therapy; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015576:Hyperostosis / Q000175:diagnosis* / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010000:Osteitis / Q000175:diagnosis* / Q000188:drug therapy; D011565:Psoriasis / Q000175:diagnosis* / Q000188:drug therapy; D012008:Recurrence; D013166:Spondylitis / Q000175:diagnosis* / Q000188:drug therapy; D013577:Syndrome; D013585:Synovitis / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D007166:Immunosuppressive Agents