title: Endoluminal brachytherapy for recurrent laryngeal carcinoma.
abstract: Early-stage squamous cell carcinoma of the larynx is usually treated with local field radiotherapy. Surgery is used for salvage following recurrence. Further recurrences present a more difficult therapeutic problem which requires individualized management. The aims of local control, survival, maintenance of function and minimizing side effects all need to be balanced according to the site and extent of disease. The present case study looks at the management of a 54-year-old man with multiple recurrences from a squamous cell carcinoma of the larynx. It describes a technique of endoluminal brachytherapy using an iridium-192 wire spiralled around the outer part of a tracheostomy tube that achieves good local control while enabling self-insertion and self-cleaning during the procedure. The dose given was 2500 cGy at 5 mm over 25.2 h and was achieved with minimal early or delayed side effects. The patient had no further symptoms relating to the stomal recurrence until his death from metastatic disease 6 months later.
authors.affiliation: Department of Radiotherapy, Sir Charles Gairdner Hospital, Royal Perth Hospital, Australia.
authors.forename: M M
authors.initials: MM
authors.lastname: Latham
authors.forename: G P
authors.initials: GP
authors.lastname: Smart
authors.forename: B
authors.initials: B
authors.lastname: Hedland-Thomas
authors.forename: C S
authors.initials: CS
authors.lastname: Harper
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*
chemical_list: D007496:Iridium Radioisotopes