title: Germinoma in cerebral hemisphere associated with Down syndrome.
abstract: A Down syndrome patient with germinoma developing in the cerebral hemisphere is reported. A review of the literature yielded only 14 cases of Down syndrome with brain tumors, including our case. This finding of brain tumors in patients with Down syndrome may reflect chance occurrence. However, it is of interest in this regard that in 6 of the 14 (43%) reported cases the lesions were intracranial germ cell tumors.
authors.affiliation: Department of Neurosurgery, Gifu University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakashima
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: N
authors.initials: N
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: A
authors.initials: A
authors.lastname: Hara
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D004314:Down Syndrome / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005625:Frontal Lobe / Q000473:pathology / Q000601:surgery; D018237:Germinoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male