Studies on kochiae fructus. IV. Anti-allergic effects of 70% ethanol extract and its component, momordin Ic from dried fruits of Kochia scoparia L.
The 70% ethanol extract (KS-ext) from Kochiae Fructus (dried fruits of Kochia scoparia L.) has been screened for activity in experimental models of type I-IV allergy. In type I allergic models, KS-ext at doses of 200 and 500 mg/kg, p.o. exhibited an inhibitory effect on 48-h homologous passive cutaneous anaphylaxis (PCA) in rats, which is related to IgE, and 1.5-h heterologous PCA in mice, which is related to IgG. In a type III allergic model, KS-ext showed an inhibitory effect on direct passive arthus reaction (DPAR) in rats, while it had no inhibitory effect on reversed cutaneous anaphylaxis (RCA) in a type II allergic model. Furthermore, in a type IV allergic model, KS-ext had an inhibitory effect on the effector phase in picryl chloride-induced contact dermatitis (PC-CD). Also, its anti-pruritogenic component, momordin Ic (oleanane saponin) exhibited inhibitory effects on 48-h homologous PCA and PC-CD. These results indicate that Kochiae Fructus not only inhibits humoral immunity but also influences cellular immunity, and should be recognized as a material for anti-allergic reactions. Also, the mode of its anti-pruritogenic activity may be mediated by anti-allergic action, and its active component may be partially attributed to momordin Ic.
Matsuda
H
H
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Dai
Y
Y
Ido
Y
Y
Yoshikawa
M
M
Kubo
M
M
D000818:Animals; D019663:Chenopodiaceae; D017449:Dermatitis, Allergic Contact / Q000517:prevention & control; D000431:Ethanol; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D007073:Immunoglobulin E / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012882:Skin Tests
D006634:Histamine H1 Antagonists; D010936:Plant Extracts; C408362:momordin I (Oleanolic Acid); D007073:Immunoglobulin E; D000431:Ethanol; D009828:Oleanolic Acid