Viral factors determining rotavirus pathogenicity.
The pathogenicity of rotaviruses depends on multiple viral and host factors. Evidence is presented for the involvement of a number of viral genes (coding for structural and non-structural proteins) in the ability of the virus to cause diarrhoea. Different genes are important in different rotavirus--host systems suggesting that there is no single viral pathogenicity factor.
Desselberger
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Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge, U.K.
D000818:Animals; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D006023:Glycoproteins / Q000502:physiology; D006801:Humans; D012401:Rotavirus / Q000235:genetics / Q000472:pathogenicity* / Q000648:ultrastructure; D014118:Toxins, Biological; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000502:physiology
D036022:Capsid Proteins; D006023:Glycoproteins; C081369:NS28 protein, rotavirus; D014118:Toxins, Biological; C060339:VP4 protein, Rotavirus; D017361:Viral Nonstructural Proteins; C104282:nsp1 protein, Rotavirus