[Histopathological study in models of chronic pancreatitis].
Histopathological findings were examined in the models of chronic pancreatitis. Using mongrel dogs, we prepared a control group (group C), a chronic ischemic group (group I), an alcohol administration group (group A), a duct obstruction group (group O), and an alcohol + obstruction group (group AO). Group I showed severe inflammatory cell infiltration, fibrosis, fat replacement and loss of acinar cells. Group A showed no change. In group O, mild periductal fibrosis was recognized. Group AO showed moderate inter-lobular fibrosis and inflammatory cell infiltration, resembling those of human chronic alcoholic pancreatitis.


CONCLUSIONS
1) Histological findings of chronic ischemic group is severer than that of group O and AO. 2) The model of alcohol administration with incomplete duct obstruction is a useful model of human chronic alcoholic pancreatitis.
Tanaka
T
T
Second Department of Surgery, Hiroshima University School of Medicine.
Ichiba
Y
Y
Miura
Y
Y
Koide
K
K
Matsugu
Y
Y
Kodo
Y
Y
Fujii
T
T
Ito
H
H
Dohi
K
K
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004285:Dogs; D005355:Fibrosis; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000209:etiology / Q000473:pathology*