Fluoride in plaque fluid and saliva after NaF or MFP rinses.
A micro-analytic method, capable of measuring the fluoride concentration in 5 nl of plaque fluid, was used to follow changes in fluoride concentration in saliva and plaque fluid at 6 single tooth-sites in 6 subjects for 180 min after a 0.048 M fluoride rinse as a NaF or MFP (sodium monofluorophosphate) solution. The maximum fluoride concentrations in saliva after NaF was 13x higher than with MFP. About 5% of the total amount of fluoride following the 20 ml NaF rinse was retained in the oral cavity. The corresponding figure followig MFP was <1%. The saliva/plaque fluid fluoride ratios for upper molars and lower incisors were significantly higher than for the upper incisors and lower molars. There was a tendency for a decline in the ratios with respect to time for all sites. To characterize the plaque fluid fluoride intra-oral single-site distribution and clearance, fluoride concentration versus time (AUC) was calculated from 10 to 60 min after a rinse. The NaF AUC followed the order: upper incisor, lower molar, upper molar and lower incisors reflecting a different exposure and clearance pattern due to the different access of the plaque to saliva. The MFP AUC values varied more, but were all significantly lower than the NaF AUC values. Analysis of plaque fluid fluoride curves at various sites revealed an exponential decline in most cases. With NaF, the baseline plaque fluid fluoride levels were not reached within 3 h. It is concluded that NaF solutions result in a significantly higher intra-oral fluoride exposure than MFP solutions. The fluoride distribution and clearance of fluoride from different sites in the oral cavity are linked to salivary access to these sites. These site-specific differences may have clinical consequences with regard to the dynamics of fluoride in the de- and remineralization processes.
Ekstrand
J
J
Department of Basic Oral Sciences, Faculty of Dentistry, Karolinska Institutet, Huddinge, Sweden. Jan.A.Ekstrand@ofa.Kl.se
D000328:Adult; D000704:Analysis of Variance; D019540:Area Under Curve; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003773:Dental Plaque / Q000737:chemistry* / Q000378:metabolism; D005122:Exudates and Transudates / Q000737:chemistry / Q000378:metabolism; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007180:Incisor; D008334:Mandible; D008437:Maxilla; D008875:Middle Aged; D008963:Molar; D009055:Mouth / Q000378:metabolism; D009067:Mouthwashes / Q000627:therapeutic use*; D010710:Phosphates / Q000008:administration & dosage / Q000627:therapeutic use*; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D017001:Tooth Demineralization / Q000378:metabolism; D014089:Tooth Remineralization
D002327:Cariostatic Agents; D009067:Mouthwashes; D010710:Phosphates; C012980:fluorophosphate; D012969:Sodium Fluoride; D005459:Fluorides