In vivo induction of sister chromatid exchanges (SCE) in a tropical fish, Etroplus suratensis (Bloch).
Sister chromatid exchange (SCE) test was applied to a tropical cultured fish, Etroplus suratensis by exposing to known mutagens. Intramuscular injections of methyl methane sulphonate (MMS) and cyclophosphamide (CP) for an exposure period of 96 h resulted in significant increase in the frequency of SCE in gill tissues. MMS induced dose dependent increase in SCE. The findings revealed that the test species in the present study may be used in mutagenicity assays for screening environmental pollutants.
Das
P
P
Central Marine Fisheries Research Institute, Cochin, India.
John
G
G
D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity; D004784:Environmental Monitoring / Q000379:methods; D004785:Environmental Pollutants / Q000633:toxicity; D005399:Fishes / Q000235:genetics*; D007273:Injections, Intramuscular; D008741:Methyl Methanesulfonate / Q000008:administration & dosage / Q000633:toxicity; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D004785:Environmental Pollutants; D009153:Mutagens; D003520:Cyclophosphamide; D008741:Methyl Methanesulfonate