Elevation of the erythrocyte sedimentation rate precedes exacerbation of bleomycin-induced pulmonary toxicity: report of two cases and review of literature.
Bleomycin is included in a number of potentially curative chemotherapy regimens. It is associated with distinct forms of pulmonary toxicity, with interstitial pneumonitis the most common. Early detection of pulmonary toxicity is not always predictable by monitoring serial chest radiographs and pulmonary function tests. Even newer serum markers are not useful indicators of bleomycin-induced pulmonary damage. Two patients developed bleomycin pulmonary toxicity, in both of whom increases in erythrocyte sedimentation rate (ESR) preceded clinical deterioration and radiographic changes. The ESR may have potential significance as a monitoring test in patients receiving bleomycin.
Higa
G M
GM
School of Pharmacy, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown 26506-9520, USA.
AlKhouri
N
N
Auber
M L
ML
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D001761:Bleomycin / Q000009:adverse effects* / Q000627:therapeutic use; D001799:Blood Sedimentation / Q000187:drug effects*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008171:Lung Diseases / Q000097:blood / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications / Q000188:drug therapy; D010412:Penile Neoplasms / Q000150:complications / Q000188:drug therapy; D011859:Radiography; D013736:Testicular Neoplasms / Q000150:complications / Q000188:drug therapy
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin