[Effects of previous small-dose irradiation on blood reaction and survival of mice after subsequent radiation and combined radiation-thermal injuries].
CBA x C57BL6 mice pre-exposed to 5 cGy gamma-irradiation then inflicted to LD70/30 acute radiation or combined injuries (radiation + thermal burn). In such protocol of the experiments preliminary "adaptive" dose radiation did not modify low 30-day survival rate and did not render an influence to the mean survival time. Leucopenia level and bone marrow devastation in 3 days after sublethal irradiation (4 Gy) or combined injury was similar in mice pre-exposed to low dose radiation (5 cGy) and in their unexposed controls. "Adaptive" dose radiation decreased leukocytes' number within the phase of hemopoiesis recovery (in 14 day after sublethal irradiation or combined injury).
Ul'ianova
L P
LP
Budagov
R S
RS
D000818:Animals; D001769:Blood / Q000528:radiation effects*; D001853:Bone Marrow / Q000528:radiation effects; D002056:Burns / Q000150:complications* / Q000401:mortality; D006410:Hematopoiesis / Q000528:radiation effects; D007970:Leukopenia / Q000209:etiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000401:mortality*; D013997:Time Factors