title: Insights into Campylobacter jejuni-induced Guillain-Barré syndrome from the Lewis rat model of experimental allergic neuritis.
abstract: Experimental allergic neuritis (EAN) is considered the in vivo model of Guillain-Barré syndrome (GBS) and has been extensively studied in the Lewis rat. Both cellular and humoral components of the immune response are implicated in the inflammatory demyelination of peripheral nerves that characterizes EAN. The recognition of Campylobacter jejuni infection as a frequent antecedent event in GBS, and in particular its association with anti-ganglioside antibodies and a primary axonal neuropathy, has raised many questions about the specific disease mechanisms involved. While C. jejuni can produce an acute motor neuropathy in chickens, confirming the relationship between C. jejuni infection and acute neuropathy, no detailed information is available from this animal model. Insights from experimental studies relating to the effector phase of Lewis rat EAN that may be relevant to C. jejuni-induced GBS are discussed.
authors.affiliation: Department of Neurology, University of Texas Health Science Center, Houston 77030, USA.
authors.forename: F J
authors.initials: FJ
authors.lastname: Vriesendorp
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D002169:Campylobacter Infections / Q000150:complications* / Q000276:immunology; D016123:Campylobacter jejuni / Q000276:immunology; D002645:Chickens; D004195:Disease Models, Animal; D000939:Epitopes / Q000276:immunology; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies; D000939:Epitopes; D005732:Gangliosides