Mechanism of depletion of liver glycogen in cancer cachexia.
Mice transplanted with a cachexia-inducing colonic adenocarcinoma (MAC16) show a progressive decrease in liver glycogen in direct proportion to the loss of body weight. Such tumours elaborate a lipid mobilizing factor (LMF), which produces a dose-dependent stimulation, not only of adipocyte adenylate cyclase, but also of hepatocyte adenylate cyclase in a GTP-dependent manner. These results suggest that LMF has the capacity to initiate hepatic glycogenolysis through an increase in cyclic AMP.
Hirai
K
K
Department of Obstetrics and Gynecology, Osaka City University Medical School, I-Asahimachi Abeno-ku, Osaka, Japan.
Ishiko
O
O
Tisdale
M
M
D000230:Adenocarcinoma / Q000503:physiopathology*; D000262:Adenylyl Cyclases / Q000378:metabolism; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002100:Cachexia / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000503:physiopathology*; D004822:Epididymis; D006160:Guanosine Triphosphate / Q000494:pharmacology; D007700:Kinetics; D008053:Lipid Mobilization / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D015431:Weight Loss
D008112:Liver Glycogen; D010455:Peptides; C008287:lipid mobilizing substance; D006160:Guanosine Triphosphate; D000262:Adenylyl Cyclases