title: [QKD: a new parameter for clinical research on hypertension].
abstract: Structural and functional heart changes induced by hypertension are easily detected nowadays by ecocardiography-Doppler. Nevertheless, this diagnostic tool is less conclusive to evaluate the large arteries modifications during hypertension. High blood pressure induces from the beginning architectural changes in all artery beds, characterized by an increase in wall thickness, reversing secondary the ratio wall thickness/lumen radio. The increase in wall stiffness as a consequence of cellular hypertrophy and hyperplasia, modifies substantially both, distensibility and compliance, two major factors in determining the grade of left ventricular hypertrophy and performance. Evaluation of pulse wave velocity implemented with a new algorhythm (QKD) permits by non-invasive ambulatory long period of time method, an indirect approach to the arterial functional state in hypertension and aging, establishing in some instances, prognosis criteria, with an accuracy even better than that given by the 24-hour load pressure index.
authors.affiliation: Servicio de Cardiología, Hospital Ramón y Cajal, Madrid. jlpalma@meditex.es
authors.forename: J L
authors.initials: JL
authors.lastname: Palma Gámiz
authors.forename: A
authors.initials: A
authors.lastname: Calderón Montero
authors.forename: M D
authors.initials: MD
authors.lastname: Isasa Gay
authors.forename: C
authors.initials: C
authors.lastname: Yrastorza de la Peña
mesh_terms: D000368:Aged; D000465:Algorithms; D015150:Echocardiography, Doppler; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy; D008875:Middle Aged; D011674:Pulse; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy