Characterization of ciprofloxacin liposomes: derivative ultraviolet spectrophotometric determinations.
Neutral, (-) and (+) charged CF encapusulated liposome formulations prepared with EPC:Chol and DPPC:Chol lipids were investigated for their loading capacity, encapsulation % and release properties. CF amounts in the liposomes were estimated using derivative UV spectroscopy. Among the liposome formulations DPPC:Chol and EPC:Chol neutral formulations had a significantly higher loading capacity and slowest release rate compared with (-) and (+) charged liposomes. The derivative UV spectroscopy was found to be an easy and sensitive method for direct estimation of CF in liposomes.
Gürsoy
A
A
Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, Haydarpaşa, Istanbul, Turkey.
Senyücel
B
B
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002939:Ciprofloxacin / Q000737:chemistry* / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000378:metabolism; D004339:Drug Compounding / Q000379:methods; D008081:Liposomes / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D003692:Delayed-Action Preparations; D008081:Liposomes; D010713:Phosphatidylcholines; D015060:1,2-Dipalmitoylphosphatidylcholine; D002939:Ciprofloxacin; D002784:Cholesterol