End-stage cystic fibrosis: improved diabetes control 2 years after successful isolated pancreatic cell and double-lung transplantation.
Over a period of years, insulin-dependent diabetes and respiratory insufficiency developed in a 35-year-old patient with end-stage cystic fibrosis. After waiting more than 4 years while receiving maintenance treatment with continuous liquid O2 and nasal ventilation, the patient underwent double-lung and pancreatic islet cell transplantation. Subsequently, the patient has enjoyed a normal life with full employment and much better control of his diabetes. Pancreatic islet cell transplantation is a simple and innocuous technique easily added to the end of lung transplantation. These new pancreatic cells, although locally injected, are still secreting more than 2 years later as assessed by repeated C-peptide measurements.
Tschopp
J M
JM
Centre Valaisan de Pneumologie, Montana, Switzerland.
Brutsche
M H
MH
Frey
J G
JG
Spiliopoulos
A
A
Nicod
L
L
Rochat
T
T
Morel
P
P
D000208:Acute Disease; D000328:Adult; D003131:Combined Modality Therapy; D003550:Cystic Fibrosis / Q000601:surgery*; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D016381:Islets of Langerhans Transplantation; D016040:Lung Transplantation; D008297:Male; D012074:Remission Induction; D012131:Respiratory Insufficiency / Q000601:surgery; D013997:Time Factors