Immunopotentiating compounds from Tinospora cordifolia.
The active principles of Tinospora cordifolia a traditional Indian plant were found to possess anticomplementary and immunomodulatory activities. Syringin (TC-4) and cordiol (TC-7) inhibited the in vitro immunohaemolysis of antibody-coated sheep erythrocytes by guinea pig serum. The reduced immunohaemolysis was found to be due to inhibition of the C3-convertase of the classical complement pathway. However, higher concentrations showed constant inhibitory effects. The compounds also gave rise to significant increases in IgG antibodies in serum. Humoral and cell-mediated immunity were also dose-dependently enhanced. Macrophage activation was reported for cordioside (TC-2), cordiofolioside A (TC-5) and cordiol (TC-7) and this activation was more pronounced with increasing incubation times.
Kapil
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Pharmacology Division, Regional Research Laboratory, Jammu Tawi, India.
Sharma
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D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003170:Complement Pathway, Alternative / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000187:drug effects; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D006968:Hypersensitivity, Delayed / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000276:immunology* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000276:immunology*; D011817:Rabbits
D000276:Adjuvants, Immunologic; D010936:Plant Extracts