title: Contamination of the pleural surfaces in childhood sarcoma. Use of colloidal P-32 to reduce radiation dose to the whole lung.
abstract: Children with pulmonary sarcomas who have diffuse contamination of the pleural cavity present a difficult management problem for the radiation oncologist. Doses required to control even microscopic disease exceed lung tolerance. We report on the use of intracavity colloid P-32 in an attempt to treat the pleural surface and spare normal lung parenchyma and tissues of the chest wall. Three children--18 months, 12 years, and 3 years of age--had spillage of pulmonary sarcomas into the chest cavity. All children were treated with systemic chemotherapy. Initially, 0.5 mCi of technetium sulfur colloid (99mTc-sulfur colloid) was instilled into the pleural space to ascertain even distribution of isotope. This was then followed by installation of 5.0 mCi of colloidal P-32. Uniform distribution was then confirmed by bremsstrahlung scanning. All three patients are in complete remission 3.5 years, 3 years, and 1 year after treatment, respectively. The major toxicity was asymptomatic pleural thickening, which could be confused with disease. This was confirmed histologically to be fibrous in the first patient. The process diminished or stabilized with time in all 3 patients over the period of observation. In this small series, intrapleural colloidal P-32 appeared to be safe and well tolerated and would be expected to be less toxic than wide-field external beam in the treatment of spilled pulmonary sarcomas.
authors.affiliation: Department of Radiation Oncology, University of Indiana Medical Center, Indiana, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Montebello
authors.forename: L
authors.initials: L
authors.lastname: Papiez
authors.forename: A R
authors.initials: AR
authors.lastname: Siddiqui
authors.forename: P P
authors.initials: PP
authors.lastname: Brietfeld
authors.forename: J
authors.initials: J
authors.lastname: Grosfeld
authors.forename: L R
authors.initials: LR
authors.lastname: Scherer
mesh_terms: D002648:Child; D002675:Child, Preschool; D003102:Colloids; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy; D008297:Male; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000627:therapeutic use*; D012074:Remission Induction; D012129:Respiratory Function Tests; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary
chemical_list: D003102:Colloids; D010761:Phosphorus Radioisotopes; D019275:Radiopharmaceuticals