title: Esophageal dysfunction in scleroderma: relationship with disease subsets.
abstract: OBJECTIVE
  To investigate the relationship between esophageal function and the extent of disease in a nonselected group of scleroderma patients, and to study gastric and small bowel motility in a group of scleroderma patients with more severe clinical manifestations.
  
  
  METHODS
  Esophageal function in 125 scleroderma patients was investigated by radiologic, endoscopic, manometric, and pH-metric techniques. Ten patients also underwent gastrointestinal (GI) manometric recording, both during fasting and after a standard meal.
  
  
  RESULTS
  Radiologic abnormalities of the esophagus were found in 55 of 81 patients (68%) and esophagitis in 45 of 125 (36%). No significant relationship was disclosed between GI symptoms, radiologic abnormalities, esophagitis grade, and the various disease subsets. However, the overall incidence of endoscopic esophagitis (irrespective of the degree) was significantly (P < 0.05) correlated with the patient subgroups, with 100% incidence of esophagitis in those having the more severe cutaneous involvement (type III). Manometric abnormalities were documented in 80% of patients, and pathologic reflux in 78%. The severity of esophageal abnormalities on manometry significantly correlated with the severity of the disease, whereas no correlations were found with pH-metric data. Ninety percent of the 10 female patients undergoing antroduodenal manometry displayed abnormal findings; of these, 60% showed neuropathic, and 30% myopathic, patterns. The latter were recorded in patients with a more severe stage of the disease (type III).
  
  
  CONCLUSIONS
  A direct relationship was observed between scleroderma subsets and the severity of esophageal (and, probably, more distal gut) motor involvement. Since no correlation was found between esophageal symptoms and the severity of manometric abnormalities, manometry should be considered the single most important GI test to document the severity of the "esophageal" disease. Gastric and small bowel manometry may also offer evidence of widespread gut involvement, and provide a rationale for a more targeted therapeutic approach.
authors.affiliation: University of Perugia Medical School, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
authors.forename: E
authors.initials: E
authors.lastname: Battaglia
authors.forename: V
authors.initials: V
authors.lastname: Debernardi
authors.forename: U
authors.initials: U
authors.lastname: Germani
authors.forename: F
authors.initials: F
authors.lastname: Quiriconi
authors.forename: L
authors.initials: L
authors.lastname: Dughera
authors.forename: G
authors.initials: G
authors.lastname: Buonafede
authors.forename: P
authors.initials: P
authors.lastname: Puiatti
authors.forename: A
authors.initials: A
authors.lastname: Morelli
authors.forename: F
authors.initials: F
authors.lastname: Spinozzi
authors.forename: P R
authors.initials: PR
authors.lastname: Mioli
authors.forename: G
authors.initials: G
authors.lastname: Emanuelli
mesh_terms: D000328:Adult; D000368:Aged; D004935:Esophageal Diseases / Q000150:complications* / Q000503:physiopathology; D004941:Esophagitis / Q000150:complications; D004945:Esophagoscopy; D004947:Esophagus / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011859:Radiography; D012595:Scleroderma, Systemic / Q000150:complications* / Q000503:physiopathology