Use of inhaled nitric oxide for ARDS.
Inhalation of low inspired concentration of nitric oxide reduces pulmonary hypertension and increases arterial oxygen tension in patients with acute respiratory distress syndrome (ARDS), and appears to be safe. Research on the physiologic mechanisms regulating the action of inhaled nitric oxide may provide clinicians with ways to further potentiate and prolong its beneficial effects.
Bigatello
L M
LM
Harvard Medical School, Boston, Massachusetts, USA.
Hurford
W E
WE
Hess
D
D
D000280:Administration, Inhalation; D000818:Animals; D002417:Cattle; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D007231:Infant, Newborn; D007962:Leukocytes / Q000187:drug effects; D009569:Nitric Oxide / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010973:Platelet Adhesiveness / Q000187:drug effects; D011379:Prognosis; D012128:Respiratory Distress Syndrome / Q000150:complications*; D015656:Respiratory Mechanics / Q000187:drug effects; D013552:Swine
D009569:Nitric Oxide