title: Databases and software for the analysis of mutations in the human p53 gene, human hprt gene and both the lacI and lacZ gene in transgenic rodents.
abstract: We have created databases and software applications for the analysis of DNA mutations at the human p53 gene, the human hprt gene and both the rodent transgenic lacI and lacZ loci. The databases themselves are stand-alone dBASE files and the software for analysis of the databases runs on IBM-compatible computers with Microsoft Windows. Each database has a separate software analysis program. The software created for these databases permit the filtering, ordering, report generation and display of information in the database. In addition, a significant number of routines have been developed for the analysis of single base substitutions. One method of obtaining the databases and software is via the World Wide Web. Open the following home page with a Web Browser: http://sunsite.unc.edu/dnam/mainpage. html . Alternatively, the databases and programs are available via public FTP from: anonymous@sunsite.unc.edu. There is no password required to enter the system. The databases and software are found beneath the subdirectory: pub/academic/biology/dna-mutations. Two other programs are available at the site, a program for comparison of mutational spectra and a program for entry of mutational data into a relational database.
authors.affiliation: Glaxo Wellcome, Inc., Medicines Safety Evaluation, 5 Moore Drive, Research Triangle Park, NC 27709, USA. nfc20355@glaxowellcome.com
authors.forename: N F
authors.initials: NF
authors.lastname: Cariello
authors.forename: G R
authors.initials: GR
authors.lastname: Douglas
authors.forename: N J
authors.initials: NJ
authors.lastname: Gorelick
authors.forename: D W
authors.initials: DW
authors.lastname: Hart
authors.forename: J D
authors.initials: JD
authors.lastname: Wilson
authors.forename: T
authors.initials: T
authors.lastname: Soussi
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001426:Bacterial Proteins / Q000235:genetics*; D003195:Computer Communication Networks; D004252:DNA Mutational Analysis; D016208:Databases, Factual; D029968:Escherichia coli Proteins; D016158:Genes, p53; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D007763:Lac Operon; D056968:Lac Repressors; D009154:Mutation; D012097:Repressor Proteins / Q000235:genetics*; D012377:Rodentia; D012984:Software
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D056968:Lac Repressors; D012097:Repressor Proteins; D007041:Hypoxanthine Phosphoribosyltransferase