Short-arm dicentric Y chromosome associated with Sertoli-cell-only tubule.
We report a case of a short-arm dicentric Y chromosome associated with Sertoli-cell-only tubule. Chromosomal analysis, using G- and C-banding techniques, revealed: 45,X/46,X psu dic(Y) (pter-->q11::q11-->pter)/46,X + mar. Staining by fluorescence in situ hybridization using a Y chromosome centromere-specific DNA probe showed two bright spots in the pseudodicentric Y chromosome and one in the marker chromosome. It is assumed that Sertoli-cell-only tubule is caused by deletion or disruption of the azoospermic factor gene located distal in Yq11.
Adachi
Y
Y
Department of Urology, Yamagata University School of Medicine, Japan.
Sasagawa
I
I
Tomaru
M
M
Ishigooka
M
M
Kubota
Y
Y
Nakada
T
T
D000328:Adult; D002871:Chromosome Banding; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology; D008297:Male; D012671:Seminiferous Tubules / Q000473:pathology*; D012708:Sertoli Cells; D012729:Sex Chromosome Aberrations / Q000473:pathology*; D014998:Y Chromosome