title: Economic evaluation of benazepril in chronic renal insufficiency.
abstract: A prospective, randomized, double-blind trial recently demonstrated that treating patients with chronic renal insufficiency with benazepril significantly decelerates the rate of progression of the disease. We tested the hypothesis that preventative treatment with the angiotensin converting enzyme (ACE) inhibitor benazepril in patients with chronic renal insufficiency is cost-effective. A Markov chain model was used that considered regular treatment, hemodialysis, continuous ambulant peritoneal dialysis, transplantation, rejection and death. Clinical trial data were used to estimate the effects of benazepril treatment and to estimate the duration until renal replacement therapy was needed. Epidemiologic parameters were derived on the basis of Dutch registries of renal diseases, costs are estimated by updating former estimates, literature review and expert opinion. We found that preventative treatment with benazepril decreased the percentage of patients who died or developed end-stage renal disease. Total costs per patient are expected to decrease in three years with more than $4,000 US per patient. Extrapolated to ten years, the savings are estimated at $23,500 US per patient. Benazepril treatment is not only an effective treatment in patients with chronic renal failure. By increasing the years spent without dialysis, it is also a cost-effective treatment.
authors.affiliation: Institute for Medical Technology Assessment, Erasmus University, Rotterdam, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: van Hout
authors.forename: G P
authors.initials: GP
authors.lastname: Simeon
authors.forename: J
authors.initials: J
authors.lastname: McDonnell
authors.forename: J F
authors.initials: JF
authors.lastname: Mann
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000191:economics* / Q000627:therapeutic use*; D001552:Benzazepines / Q000191:economics* / Q000627:therapeutic use*; D003365:Costs and Cost Analysis; D003404:Creatinine / Q000097:blood; D004311:Double-Blind Method; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000191:economics* / Q000453:epidemiology; D008390:Markov Chains; D018803:Models, Economic; D011446:Prospective Studies; D006435:Renal Dialysis / Q000191:economics
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; D003404:Creatinine; C044946:benazepril