Hormone replacement therapy and intraocular pressure.
OBJECTIVE
To evaluate the effect of hormone replacement therapy (HRT) on intraocular pressure (IOP) in menopausal women.


METHODS
The IOP of 25 white menopausal women without an abnormal ophthalmologic history was measured before and during HRT regimen. IOP fluctations were recorded before and 1, 4, and 12 weeks after the beginning of HRT. These measurements were obtained according to a standardized time schedule (08:00, 12:00, 16:00, and 19:00 h).


RESULTS
The mean IOP in the left eye decreased from 16.2 +/- 2.4 mmHg before therapy to 14.0 +/- 2.1 mmHg after 12 weeks of therapy (P < 0.001). In the right eye, whose IOP was at 15.3 +/- 2.3 mmHg before therapy there was a decrease to 14.0 +/- 1.9 mmHg after 12 weeks of therapy (P < 0.001).


CONCLUSIONS
Hormone replacement therapy has a positive effect on IOP in menopausal women.
Sator
M O
MO
Department of Obstetrics and Gynecology, General Hospital, University of Vienna, Austria. michael.sator@akh-wien.ac.at
Joura
E A
EA
Frigo
P
P
Kurz
C
C
Metka
M
M
Hommer
A
A
Huber
J C
JC
D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors