title: Dust mite allergen avoidance in the treatment of hospitalized children with asthma.
abstract: BACKGROUND
  Asthma is a leading cause of hospital admission in children. The majority of children with asthma are sensitized and exposed to inhalant allergens that may contribute to chronic airway inflammation.
  
  
  OBJECTIVE
  To evaluate the practicality and effects of dust mite (D. farinae and D. pteronyssinus) allergen avoidance in homes of children hospitalized with acute asthma.
  
  
  METHODS
  Children 5 to 18 years of age who were admitted with asthma to a suburban Atlanta hospital were randomly assigned, without knowledge of allergen sensitization or exposure in their houses, to active (n = 13) or placebo (n = 10) treatment group. Active treatment included encasing mattress, box springs, and pillows in allergen impermeable covers; weekly hot water wash of bed linens; replacement of bedroom carpet with polished flooring; and 3% tannic acid spray to living room carpet. Placebo treatment included permeable encasing for bedding, cold water wash, and water spray for carpet. Dust samples were analyzed for dust mite, cockroach, and cat allergens, while serum samples were analyzed for IgE antibodies to the same allergens. Outcome measures included daily peak expiratory flow rates, spirometry, methacholine inhalation challenge, and hospital readmission.
  
  
  RESULTS
  Children in both groups were similar by demographics, sensitization, and exposure to dust mite allergen. Allergen levels fell > 3-fold in many active and placebo homes. Children in the active group had improved PEFR at 3 and 6 months after intervention (P < .04, P < .05, respectively). Six of seven children in the study who were sensitized and exposed to dust mite allergen demonstrated improved PEFR at 3 months when allergen levels fell in both bedding and bedroom floor. There was no difference in FEV1 or methacholine challenge, although a few children in either group could tolerate methacholine because of bronchial hyperreactivity. Six children (four active and two placebo) were readmitted to hospital during the study.
  
  
  CONCLUSIONS
  Increases in PEFR were recorded among children in the active treatment group and also among sensitized patients whose dust mite allergens fell. These results support the hypothesis that avoidance can be effective even among children admitted to hospital. The study was complicated by insufficient numbers of mite-allergic children and poor compliance with diaries and the protocol. Recruitment from the hospital resulted in participants with more severe asthma than anticipated. The results also suggest that many of the patients in this group will continue to have exacerbations triggered by upper or lower respiratory tract infections.
authors.affiliation: Department of Medicine, University of Virginia, Charlottesville, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Hayden
authors.forename: M
authors.initials: M
authors.lastname: Perzanowski
authors.forename: L
authors.initials: L
authors.lastname: Matheson
authors.forename: P
authors.initials: P
authors.lastname: Scott
authors.forename: R S
authors.initials: RS
authors.lastname: Call
authors.forename: T A
authors.initials: TA
authors.lastname: Platts-Mills
mesh_terms: D000293:Adolescent; D016902:Air Pollution, Indoor / Q000032:analysis; D000485:Allergens; D000818:Animals; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D004391:Dust / Q000009:adverse effects; D006023:Glycoproteins; D006801:Humans; D008925:Mites / Q000276:immunology; D010366:Peak Expiratory Flow Rate; D013147:Spirometry
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D004391:Dust; D006023:Glycoproteins