title: Acute lymphoblastic leukemia with isolated adrenocorticotropic hormone deficiency.
abstract: A 57-year-old female was admitted to our hospital because of Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). On admission, disturbance of consciousness and hyponatremia were recognized. The patient's endocrinological data showed low levels of adrenocorticotropic hormone (ACTH) (less than 5 pg/ml) and cortisol (5.9 microg/dl). Other anterior pituitary hormones were normal. Plasma ACTH and cortisol did not respond to the corticotropin releasing factor (CRF) test. A diagnosis of isolated ACTH deficiency was made. This is a rare case of isolated ACTH deficiency complicated with hematological malignancies.
authors.affiliation: Department of Internal Medicine, Nippon Medical School, Sendagi, Tokyo.
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Mamiya
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Tajika
authors.forename: H
authors.initials: H
authors.lastname: Sugihara
authors.forename: S
authors.initials: S
authors.lastname: Gomi
authors.forename: K
authors.initials: K
authors.lastname: Inokuchi
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Shibazaki
authors.forename: K
authors.initials: K
authors.lastname: Dan
authors.forename: I
authors.initials: I
authors.lastname: Wakabayashi
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000150:complications / Q000188:drug therapy; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D014750:Vincristine; D004317:Doxorubicin; D000324:Adrenocorticotropic Hormone; D011239:Prednisolone