Clotting factor IX levels in C/EBP alpha knockout mice.
Previous studies have indicated that C/EBP alpha is involved in the regulation of factor IX and mutations of a C/EBP recognition element in the factor IX promoter result in haemophilia B. We now report that mice homozygous for the deletion of the c/ebp alpha gene are significantly deficient in factor IX transcription.
Davies
N
N
Chemical Pathology Unit, Sir William Dunn School of Pathology, University of Oxford.
Austen
D E
DE
Wilde
M D
MD
Darlington
G J
GJ
Brownlee
G G
GG
D000818:Animals; D015152:Blotting, Northern; D005164:Factor IX / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic
D012333:RNA, Messenger; D005164:Factor IX