title: Antiseptic effects at injection sites.
abstract: To our knowledge, there are no published papers detailing antisepsis for injection sites. In view of this, the efficacies of povidone-iodine (PVP-I) ethanol solution and chlorhexidine (CH) ethanol, the agents most commonly used for antisepsis of the operative field, were compared. Before and after the injection site was disinfected with either of these antiseptics, specimens of indigenous bacteria on the skin were collected by the cylinder scrub method, and the bacteria reduction rate and the reduction factor (RF) were determined to evaluate the efficacy of antisepsis. The bacteria reduction rate and RF value obtained for PVP-I ethanol were 95.1 +/- 11.2 and 2.1 +/- 0.9% and those for CH ethanol were 93.5 +/- 9.3 and 1.8 +/- 0.9%. Since there were individual differences in cell count before antisepsis, no significant difference was seen in bactericidal activity. However, slightly more favorable results were obtained with PVP-I ethanol. Although it is impossible to eradicate completely the indigenous microbes with currently available methods, it is considered important for the prevention of infection of the injection site to decrease bacterial counts as much as possible.
authors.affiliation: Surgical Center, Okayama University Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Arata
authors.forename: M
authors.initials: M
authors.lastname: Kamitani
authors.forename: T
authors.initials: T
authors.lastname: Miyai
authors.forename: M
authors.initials: M
authors.lastname: Ito
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D000985:Antisepsis; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D001424:Bacterial Infections / Q000517:prevention & control; D018890:Chemoprevention; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use; D015169:Colony Count, Microbial; D018592:Cross-Over Studies; D000431:Ethanol / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007267:Injections / Q000009:adverse effects; D007466:Iodophors / Q000008:administration & dosage / Q000627:therapeutic use*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000627:therapeutic use*; D012867:Skin / Q000382:microbiology*
chemical_list: D000891:Anti-Infective Agents, Local; D007466:Iodophors; D000431:Ethanol; D011206:Povidone-Iodine; D002710:Chlorhexidine