Representation of amino acid sequences in terms of interaction energy in protein globules.
We suggest a new simple approach for comparing the primary structure of proteins and their spatial structure. It relies on the one-to-one correspondence between each residue of the polypeptide chain and the energy of van der Waals interactions between the regions of the native globule flanking this residue. The method obviates the sophisticated geometrical criteria for estimating similarity between spatial structures. Besides, it permits one to analyze structural units of different scale.
Berezovsky
I N
IN
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. ber@imb.imb.ac.ru
Tumanyan
V G
VG
Esipova
N G
NG
D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D003198:Computer Simulation; D004722:Endoribonucleases / Q000737:chemistry; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D016914:Ribonuclease H / Q000737:chemistry; D012260:Ribonucleases / Q000737:chemistry*; D012984:Software
D001426:Bacterial Proteins; D011506:Proteins; D004722:Endoribonucleases; D012260:Ribonucleases; D016914:Ribonuclease H; C019760:Bacillus amyloliquefaciens ribonuclease; C022543:ribonuclease T(2)