An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population.
A polymorphism in the 5' region of the serotonin transporter gene modulates its transcription efficiency. Its short allele has been reported to be associated with neurotic traits. The serotonin transporter is the action site of selective serotonin re-uptake inhibitors, widely used in the treatment of panic disorder. We examined an association between the polymorphism and panic disorder in a case-control study consisting of 66 Japanese patients and 150 controls. The short allele was significantly more frequent in the Japanese than in Caucasians. The patients and the controls had similar allele frequencies, indicating no association between the polymorphism and panic disorder in most Japanese patients.
Ishiguro
H
H
Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Japan.
Arinami
T
T
Yamada
K
K
Otsuka
Y
Y
Toru
M
M
Shibuya
H
H
D000328:Adult; D000368:Aged; D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000032:analysis / Q000235:genetics; D004311:Double-Blind Method; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D016584:Panic Disorder / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins; D014158:Transcription, Genetic
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; D004247:DNA