Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant.
Two new (3 and 5), as well as three known (1, 2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae), a medicinal plant of North America. The structures were established by 1H and 13C NMR. The absolute configurations of 2 and 5 were determined by application of Mosher's method. All the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium avium at 10 micrograms/disk in a disk diffusion assay.
Kobaisy
M
M
Botany and Microbiology, University of British Columbia, Vancouver, Canada.
Abramowski
Z
Z
Lermer
L
L
Saxena
G
G
Hancock
R E
RE
Towers
G H
GH
Doxsee
D
D
Stokes
R W
RW
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D009162:Mycobacterium avium / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019441:Plant Epidermis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011090:Polyenes / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D011090:Polyenes; D007538:Isoniazid