[The effect on painful and silent myocardial ischemia of the preparations Efox and Efox Long in patients with stenocardia of effort].
The study of two novel drugs for management of both painful and silent myocardial ischemia isosorbide-5-mononitrate (IS-5-MN), efox, and its long-acting variant efox-long demonstrated that both drugs exerted noticeable antianginal effect at maximal concentration in blood. This was achieved by a single dose and course administration. The differences in the effects of the two dosage forms of IS-5-MN on painless ischemia may be explained by limited coronary reserves of anginal patients.
Belousov
Iu B
IuB
Egorova
N A
NA
Karasev
A V
AV
Upnitskiĭ
A A
AA
D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D005082:Physical Exertion / Q000187:drug effects; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate