Migration activity of microglia and macrophages into rat brain.
We examined the entry of intra-arterially injected microglia and macrophages into the brain using a rat muscle graft model to compare their respective abilities to invade the brain parenchyma. Isolated microglia without any activation treatment entered into the brain with or without the muscle graft, while macrophages activated by phorbol 12-myristate-13-acetate (PMA) entered the brain only in the presence of the muscle graft. These results suggest that microglia have a higher affinity for the brain than macrophages.
Imai
F
F
Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan.
Sawada
M
M
Suzuki
H
H
Kiya
N
N
Hayakawa
M
M
Nagatsu
T
T
Marunouchi
T
T
Kanno
T
T
D000818:Animals; D000831:Animals, Newborn; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D002465:Cell Movement; D002531:Cerebellum / Q000166:cytology; D002552:Cerebral Ventricles; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology; D017628:Microglia / Q000187:drug effects / Q000502:physiology*; D018482:Muscle, Skeletal / Q000637:transplantation; D051381:Rats; D011916:Rats, Inbred F344; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D013755:Tetradecanoylphorbol Acetate