title: Targeted vinblastine chemotherapy with two preparations of lipiodol contrast medium.
abstract: BACKGROUND
  Long-term survival and cure can not be achieved in patients with unresectable metastatic liver cancer. In this study, to improve the antitumor activity of oily anticancer agents, which enable targeted cancer chemotherapy, various concentrations of vinblastine dissolved in Lipiodol ultrafluid (vinblastine/Lipiodol U) or Lipiodol F, which has three times the viscosity of Lipiodol ultrafluid, were used.
  
  
  METHODS
  Rabbits bearing VX2 tumors measuring 1 to 2 cm in diameter in the liver received arterial injections of 0.2 ml of these drugs, and antitumor activity were examined.
  
  
  RESULTS
  Complete necrosis of the tumor was observed in three of nine rabbits received vinblastine/Lipiodol U at 2.5 mg/ml. Complete necrosis of the tumor was observed in all eleven rabbits which received vinblastine/Lipiodol U at 5 mg/ml. At concentrations of 7.5 and 10 mg/ml, the necrotic area spread from the tumor to the liver parenchyma surrounding the tumor. The antitumor activity of vinblastine dissolved in Lipiodol F was increased compared with that of vinblastine dissolved in Lipiodol ultrafluid.
  
  
  CONCLUSIONS
  The antitumor activity of a kind of the oily anticancer agents, vinblastine/Lipiodol increased with increasing amounts of vinblastine dissolved in Lipiodol ultrafluid and with the increasing viscosity of the carrier, Lipiodol.
authors.affiliation: First Department of Surgery, Kumamoto University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oda
authors.forename: T
authors.initials: T
authors.lastname: Konno
authors.forename: A
authors.initials: A
authors.lastname: Nagamitsu
authors.forename: K
authors.initials: K
authors.lastname: Tabaru
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: N
authors.initials: N
authors.lastname: Kitamura
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D007459:Iodized Oil / Q000008:administration & dosage*; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009821:Oils; D011817:Rabbits; D012997:Solvents; D014747:Vinblastine / Q000008:administration & dosage*; D014783:Viscosity
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D009821:Oils; D012997:Solvents; D014747:Vinblastine; D007459:Iodized Oil