Spatial summation of perceived pressure, sharpness and mechanically evoked cutaneous pain.
Psychophysically, spatial summation can be demonstrated as a decrease in threshold accompanying an increased field of stimulation. The present study examined to what extent different mechanically evoked percepts (pressure, sharpness, and pain) show spatial summation. Various probes were used to apply prescribed forces to the dorsal surface of the digits of 19 healthy subjects. The threshold for three perceptual qualities showed differing degrees of spatial summation: sharpness showed no statistically significant spatial summation; pain demonstrated some significant summation (46% on average); pressure showed the greatest degree of spatial summation (76% on average). The lack of significant spatial summation for sharpness threshold is consistent with the theory that perceived sharpness can be evoked by near threshold activity of a single nociceptor. The modest amount of spatial summation for pain implies that distinctly suprathreshold activation of nociceptors is required for mechanically evoked pain perception, and such input summates centrally, but not completely. The greater spatial summation observed for pressure vs. pain thresholds implies a greater degree of central summation for slowly adapting mechanoreceptors vs. nociceptors.
Greenspan
J D
JD
Program in Neuroscience, SUNY Health Science Center at Syracuse 13210, USA. jdg001@dental3.ab.umd.edu
Thomadaki
M
M
McGillis
S L
SL
D000328:Adult; D000344:Afferent Pathways / Q000502:physiology; D005260:Female; D006801:Humans; D007699:Kinesthesis / Q000502:physiology; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D008875:Middle Aged; D009619:Nociceptors / Q000502:physiology*; D009949:Orientation / Q000502:physiology; D017288:Pain Threshold / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology; D010812:Physical Stimulation; D011312:Pressure; D011601:Psychophysics; D011999:Recruitment, Neurophysiological / Q000502:physiology*; D012016:Reference Values; D012867:Skin / Q000294:innervation*; D009435:Synaptic Transmission / Q000502:physiology