Alterations of male Wistar rat jejunum induced by Dodine (n-dodecylguanidine acetate).
The effect of Dodine on the intestine was studied after a single administration of 1000 mg/kg, which corresponds to the LD50 in male Wistar rats. At this dose, a significant decrease in body weight was observed, accompanied by diarrhea, which may be associated with intestinal alterations. The chemical induced a significant reduction of the protein content and in sucrase activity in the jejunum. Morphological alterations included a significant decrease in crypt height and in villus length and depth. The intestinal modifications observed in animals after Dodine administration may explain the observed loss in body weight and diarrhea.
Mitjans
M
M
Unitat de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Spain.
Vinardell
M P
MP
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005659:Fungicides, Industrial / Q000633:toxicity*; D006146:Guanidines / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects; D007583:Jejunum / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008871:Microvilli / Q000201:enzymology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013393:Sucrase / Q000187:drug effects / Q000378:metabolism
D005659:Fungicides, Industrial; D006146:Guanidines; D011506:Proteins; C006921:dodine; D013393:Sucrase