Ontogeny of electrically evoked brain stem potentials in neonatally deafened gerbils (Meriones unguiculatus) after cochlear implantation.
To investigate the ontogeny of the electrically evoked auditory brainstem response (E-ABR) we used an animal model of neonatally deafened gerbils with an intracochlear implanted electrode. The E-ABR were recorded in three groups: normal hearing animals (NORM) and binaural deafened without chronical electrostimulation (BD) in comparison to binaural deafened animals with chronical stimulation (BDS). In group BD the deafening lead to inter-peak-latency II-V increase and histological degeneration in the Cochlear Nucleus. In chronical stimulated animals (BDS) we could not observe significant differences compared to unstimulated gerbils until the day after birth. In further studies longer stimulation periods, recordings of electrically evoked middle latency response as well as histological examinations of more central parts of the auditory pathway will be included.
Walger
M
M
ENT University Hospital of Cologne, Germany.
Hessel
H
H
Ernst
S
S
von Wedel
H
H
D000818:Animals; D000831:Animals, Newborn; D019929:Cochlear Implantation; D003638:Deafness / Q000601:surgery*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005849:Gerbillinae