title: How rolling circle plasmids control their copy number.
abstract: Rolling circle DNA replication is inherently continuous and unregulated. This 'go-for-broke' strategy works well for lytic phages but is suicidal for plasmids that must coexist with their host. Plasmids have consequently evolved elaborate copy number control systems that operate at the transcriptional, translational and post-translational levels.
authors.affiliation: CFSAN Divn of Microbiological Studies, US Food and Drug Administration, Washington, DC 20204, USA. axr@vm.cfsan.fda.gov
authors.forename: A
authors.initials: A
authors.lastname: Rasooly
authors.forename: R S
authors.initials: RS
authors.lastname: Rasooly
mesh_terms: D004265:DNA Helicases / Q000096:biosynthesis / Q000235:genetics; D004261:DNA Replication; D004268:DNA-Binding Proteins; D008954:Models, Biological; D010957:Plasmids / Q000096:biosynthesis* / Q000235:genetics*; D012313:RNA / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D015534:Trans-Activators; C045264:replication initiator protein; D012313:RNA; D004265:DNA Helicases