Are bacterial exotoxins cytokine network regulators?
Bacterial exotoxins are generally thought to act by damaging cells or altering cell metabolism. However, recent work has established that many exotoxins modulate eukaryotic cell cytokine synthesis. Cytokine induction may play a significant role in exotoxin action, and therapeutic targeting of cytokines could be beneficial in infectious diseases involving bacterial exotoxins.
Henderson
B
B
Cellular Microbiology Research Group, Eastman Dental Institute, University College London, UK. b.henderson@eastman.ucl.ac.uk
Wilson
M
M
Wren
B
B
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D001419:Bacteria / Q000276:immunology / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology / Q000628:therapy; D001427:Bacterial Toxins / Q000145:classification / Q000633:toxicity*; D016207:Cytokines / Q000096:biosynthesis*; D005098:Exotoxins / Q000145:classification / Q000633:toxicity*; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular; D008954:Models, Biological
D001427:Bacterial Toxins; D016207:Cytokines; D005098:Exotoxins; D000246:Adenosine Diphosphate Ribose; D006026:Glycoside Hydrolases