Pressure modulates monocyte migration.
Migration of monocytes into the subendothelial space of the aorta has been considered to be an important event in the development of atherosclerosis. Because hypertension is commonly associated with atherosclerosis, we studied the effect of applied pressure on the migration of monocytes. Direct applied pressure increased the migration (P < .001) of monocytes across a filter when compared with normal atmospheric pressure. The migration of monocytes was found to be directly related to the amount of the applied pressure. Amlodipine, a calcium channel blocker, attenuated the migration of monocytes under normal as well as increased pressure conditions in a dose-dependent manner. These studies provide a basis to speculate on the role of direct pressure in the migration of monocytes into the subendothelial space and the possibility that vasoactive agents may modulate the migration of monocytes independent of their pressure-lowering effect.
Singhal
P C
PC
Department of Medicine, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park 11040, USA.
Sagar
P
P
Gupta
S
S
Arya
M
M
Gupta
M
M
Prasad
A
A
Loona
R
R
Sharma
P
P
Mattana
J
J
D017311:Amlodipine / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D006801:Humans; D016177:Macrophage-1 Antigen / Q000096:biosynthesis; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011312:Pressure; D012333:RNA, Messenger / Q000096:biosynthesis; D013997:Time Factors
D002121:Calcium Channel Blockers; D016177:Macrophage-1 Antigen; D012333:RNA, Messenger; D017311:Amlodipine