title: Indocyanine green angiography in central serous chorioretinopathy. ICG angiography in CSC.
abstract: OBJECTIVE
  To analyse images obtained by indocyanine green angiography in central serous chorioretinopathy (CSC).
  
  
  METHODS
  Ninety patients affected with CSC were examined using indocyanine green angiography.
  
  
  RESULTS
  CSC was detected in 127 of the 180 eyes examined. Leakage points were detected in 99 eyes with fluorescein angiography; in 85 of these eyes, they corresponded to hyperfluorescence with indocyanine green angiography, while a hyperfluorescence of the neuroepithelial detachment was seen in 21 eyes. Areas of choroidal hyperpermeability were seen in all 127 eyes with CSC and in 9 fellow eyes. With ICG angiography, the appearance of pigment epithelial detachments was similar to that previously described (early hyperfluorescence and later hypofluorescence), and was seen in 47 eyes. In 103 eyes, hypofluorescent lesions of various sizes, were detected which became more marked in the later stages. These lesions corresponded to retinal pigment epithelium lesions in fluorescein angiography, mainly hyperfluorescence caused by window defect. We were also able to observe RPE atrophic tracts in 31 eyes. These tracts appeared hyperfluorescent in 11 eyes where a minimal amount of RPE atrophy was present and hypofluorescent in 20 eyes in which the tract had marked RPE atrophy.
  
  
  CONCLUSIONS
  The results obtained confirm the finding of choroidal hyperpermeability and subretinal diffusion of ICG, which indicate involvement of the choroid in CSC. The observation of progressively hypofluorescent lesions corresponding to retinal pigment epithelium alterations suggests that there may be as yet unknown interactions of pigment epithelium and ICG.
authors.affiliation: Department of Ophthalmology, University of Udine.
authors.forename: U
authors.initials: U
authors.lastname: Menchini
authors.forename: G
authors.initials: G
authors.lastname: Virgili
authors.forename: P
authors.initials: P
authors.lastname: Lanzetta
authors.forename: E
authors.initials: E
authors.lastname: Ferrari
mesh_terms: D000328:Adult; D000368:Aged; D001284:Atrophy; D002829:Choroid / Q000378:metabolism; D015862:Choroid Diseases / Q000175:diagnosis*; D004396:Coloring Agents / Q000493:pharmacokinetics; D004058:Diffusion; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D010539:Permeability; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012160:Retina / Q000378:metabolism; D012163:Retinal Detachment / Q000175:diagnosis; D012164:Retinal Diseases / Q000175:diagnosis*; D012189:Retrospective Studies
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green