Response to the varicella vaccine in children with nephrotic syndrome.
Varicella vaccine was administered to seven children with corticosteroid-sensitive nephrotic syndrome. Immunization was not associated with any significant reactions or with increased frequency of relapse. The antibody response was, however, variable and a second dose was necessary before seroconversion was achieved in four patients. The findings indicate that immunization with varicella vaccine is safe in children with nephrotic syndrome in remission, but that a two-dose vaccine schedule should be considered.
Quien
R M
RM
Department of Pediatrics, Christopher's Hospital for Children, Philadelphia, Pennsylvania 19134, USA.
Kaiser
B A
BA
Deforest
A
A
Polinsky
M S
MS
Fisher
M
M
Baluarte
H J
HJ
D000914:Antibodies, Viral / Q000096:biosynthesis; D002644:Chickenpox / Q000276:immunology / Q000517:prevention & control*; D019433:Chickenpox Vaccine; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D007115:Immunization Schedule; D009404:Nephrotic Syndrome / Q000276:immunology*; D012075:Remission, Spontaneous
D000914:Antibodies, Viral; D019433:Chickenpox Vaccine