title: Effect of aging on psychological stress-induced increases in noradrenaline release in the rat anterior hypothalamus: an in vivo microdialysis study.
abstract: Basal and psychological stress-induced noradrenaline (NA) release were studied by intracerebral microdialysis in the hypothalamus of rats aged 9 weeks or 12 months. Basal NA output was not significantly different between young (9-week-old; 2.11 +/- 0.22 pg/20 min) and aged (12-month-old; 2.29 +/- 0.34 pg/20 min) rats. Psychological stress for 20 min significantly increased NA release in both groups (186% and 142% of baseline at 9 weeks old and 12 months old, respectively); however, the increase in aged rats was significantly lower than that in young rats (P < 0.01). This finding suggest that the noradrenergic neuronal response to psychological stress is attenuated in aged rats.
authors.affiliation: Department of Pharmacology, Kurume University School of Medicine, Japan.
authors.forename: Y L
authors.initials: YL
authors.lastname: Wu
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Yokoo
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Tomita
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000523:psychology; D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology
chemical_list: D009638:Norepinephrine