Immunization against the agent of human granulocytic ehrlichiosis in a murine model.
The agent of human granulocytic ehrlichiosis (HGE) is a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes. C3H/HeN mice can become infected with the agent of HGE (designated aoHGE) by syringe inoculation or tick-borne infection and develop transient neutropenia. They thereby partially mimic human disease and provide a model in which to study immunity to this microorganism. Mice vaccinated with lysates of purified aoHGE, or administered aoHGE antisera, were partially protected from both syringe- and tick-transmitted challenge with aoHGE. These data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE.
Sun
W
W
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
IJdo
J W
JW
Telford
S R
SR
Hodzic
E
E
Zhang
Y
Y
Barthold
S W
SW
Fikrig
E
E
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D004269:DNA, Bacterial; D004195:Disease Models, Animal; D016873:Ehrlichiosis / Q000276:immunology / Q000517:prevention & control*; D006098:Granulocytes; D018922:HL-60 Cells; D006801:Humans; D007116:Immunization, Passive; D018884:Ixodes / Q000382:microbiology; D051379:Mice; D008809:Mice, Inbred C3H; D014611:Vaccination
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004269:DNA, Bacterial