Inhibition of striatal energy metabolism produces cell loss in the ipsilateral substantia nigra.
This study examined whether damage to dopamine (DA) nerve terminals via inhibition of energy metabolism in the striatum would result in the retrograde loss of cell bodies in the substantia nigra. Infusion of 2 micromol malonate into the left striatum of rats resulted in a 67% loss of striatal DA and a 40% loss of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. No change in the number of Nissl-positive-TH-negative neurons was observed. These findings demonstrate the retrograde destruction of DA cell bodies in the substantia nigra resulting from energy impairment at their terminal projection site.
Sonsalla
P K
PK
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Department of Neurology, Piscataway 08854, USA.
Manzino
L
L
Sinton
C M
CM
Liang
C L
CL
German
D C
DC
Zeevalk
G D
GD
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D004298:Dopamine / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D007839:Functional Laterality; D007263:Infusions, Parenteral; D008297:Male; D008314:Malonates / Q000008:administration & dosage / Q000633:toxicity*; D009411:Nerve Endings / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D008314:Malonates; C030290:malonic acid; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine