Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease.
We have constructed transgenic (Tg) mice expressing the entire human immunodeficiency virus type 1 (HIV-1) coding sequences in cells targeted by HIV-1 infection in humans. These Tg mice developed a severe AIDS-like disease leading to early death (< 1 month). They developed muscle wasting, severe atrophy and fibrosis of lymphoid organs, tubulointerstitial nephritis, and lymphoid interstitial pneumonitis. In addition the expression of RANTES was increased in various tissues of these Tg mice relative to that in the normal controls. Disease appearance was correlated with the levels of transgene expression. The numerous pathologies observed in these mice are remarkably similar to those observed in human AIDS and, more specifically, in pediatric AIDS.
Hanna
Z
Z
Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada.
Kay
D G
DG
Cool
M
M
Jothy
S
S
Rebai
N
N
Jolicoeur
P
P
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D000818:Animals; D001483:Base Sequence; D015704:CD4 Antigens / Q000235:genetics; D018946:Chemokine CCL5 / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D015870:Gene Expression; D016679:Genome, Viral; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007107:Immune System / Q000821:virology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009030:Mosaicism; D010641:Phenotype
D015704:CD4 Antigens; D018946:Chemokine CCL5; D017931:DNA Primers