title: Hepatic injury localized to the field of total lymphoid irradiation.
abstract: A 37-year-old woman with severe aplastic anemia underwent allogeneic bone marrow transplantation following cyclophosphamide (CY) and total lymphoid irradiation (TLI). On day +30, a CT scan was carried out because of a mild elevation in liver enzymes, and it revealed a low density area with a sharp border in the left lobe corresponding to the irradiated area. MRI showed a hypersignal intensity on both T1 and T2-weighted images and suggested that hepatic damage was mainly severe fatty change. These abnormalities resolved with no treatment. CY with TLI for adult patients with severe aplastic anemia may induce hepatic injury.
authors.affiliation: Department of Internal Medicine, Japanese Red Cross Nagoya First Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Murata
authors.forename: H
authors.initials: H
authors.lastname: Muramoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Nishida
authors.forename: M
authors.initials: M
authors.lastname: Haneda
authors.forename: T
authors.initials: T
authors.lastname: Kanie
authors.forename: H
authors.initials: H
authors.lastname: Taji
authors.forename: M
authors.initials: M
authors.lastname: Hamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Minami
authors.forename: T
authors.initials: T
authors.lastname: Imaeda
authors.forename: Y
authors.initials: Y
authors.lastname: Kodera
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000008:administration & dosage; D005234:Fatty Liver / Q000209:etiology*; D005260:Female; D006801:Humans; D019190:Iron Overload / Q000150:complications; D008099:Liver / Q000528:radiation effects*; D008111:Liver Function Tests; D015182:Lymphatic Irradiation / Q000009:adverse effects*; D011832:Radiation Injuries / Q000209:etiology*; D016879:Salvage Therapy; D065227:Transfusion Reaction; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014184:Transplantation, Homologous
chemical_list: D003520:Cyclophosphamide