Effect of 6 months of growth hormone treatment in young children with Prader-Willi syndrome.
Nine prepubertal children with Prader-Willi syndrome were treated with growth hormone (GH; 24 IU/m2/week) for 6 months. Mean height increased by 0.8 SD and mean weight for height decreased by 0.7 SD over this 6-month treatment period. Body fat, measured by dual-energy X-ray absorptiometry, decreased by 22.5% over the period of GH treatment, whereas fat-free mass increased by 14%. These preliminary results indicate that GH is effective in increasing height and normalizing body composition in patients with Prader-Willi syndrome.
Eiholzer
U
U
Centre for Adolescent Medicine, Zurich, Switzerland.
Weber
R
R
Stutz
K
K
Steinert
H
H
D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth / Q000187:drug effects; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D011218:Prader-Willi Syndrome / Q000188:drug therapy*
D019382:Human Growth Hormone