title: Serum levels of some acute phase proteins in kidney and urinary tract urothelial cancers.
abstract: Early diagnosis of kidney and urothelial cancer requires some new sensitive and specific methods. In this study the diagnostic use of serum alpha 1-acid glycoprotein (alpha 1-AG), coeruloplasmin, alpha 1-antitrypsin (alpha 1-AT), alpha 2-macroglobulin (alpha 2-MG) and albumin in patients with kidney, urinary bladder and upper tract urothelial cancer was evaluated. In kidney cancer patients the serum levels of alpha 1-AG, coeruloplasmin and alpha 1-AT were significantly increased over the controls (p < 0.001), however, albumin was decreased (p < 0.005). Sensitivity was relatively high for alpha 1-AG (85%), albumin (85%) and alpha 1-AT (77%). In patients with urinary tract urothelial cancer alpha 1-AG, alpha 1-AT and coeruloplasmin were also increased but not as much as in kidney cancer. Sensitivity of alpha 1-AG (63%), albumin (75%) and alpha 1-AT (66%) was also lower than in kidney cancer. This study has established the relative importance of alpha 1-AT and albumin determination in patients with kidney as well as with urothelial cancer.
authors.affiliation: Institute of Nephrology and Haemodialysis, Faculty of Medicine, Nis, Yugoslavia.
authors.forename: M
authors.initials: M
authors.lastname: Pejovic
authors.forename: V
authors.initials: V
authors.lastname: Djordjevic
authors.forename: I
authors.initials: I
authors.lastname: Ignjatovic
authors.forename: T
authors.initials: T
authors.lastname: Stamenic
authors.forename: V
authors.initials: V
authors.lastname: Stefanovic
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D002570:Ceruloplasmin / Q000032:analysis; D005189:False Positive Reactions; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood*; D009961:Orosomucoid / Q000032:analysis; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000032:analysis*; D001749:Urinary Bladder Neoplasms / Q000097:blood*; D014571:Urologic Neoplasms / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D000209:Acute-Phase Proteins; D009961:Orosomucoid; D012709:Serum Albumin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D002570:Ceruloplasmin