title: Treatment of methanol poisoning with intravenous 4-methylpyrazole.
abstract: Treatment of human methanol poisoning with the alcohol dehydrogenase inhibitor, 4-methylpyrazole (fomepizole), has not been previously described. We report the clinical and toxicokinetic data of a patient with methanol poisoning who was treated with fomepizole. Formic acid levels remained undetectable during fomepizole treatment, the toxic effects of methanol were prevented, and the patient made a full recovery.
authors.affiliation: Department of Emergency Medicine, University of Massachusetts Medical Center, Worcester, USA. mburns@bidmc.harvard.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Burns
authors.forename: A
authors.initials: A
authors.lastname: Graudins
authors.forename: C K
authors.initials: CK
authors.lastname: Aaron
authors.forename: K
authors.initials: K
authors.lastname: McMartin
authors.forename: J
authors.initials: J
authors.lastname: Brent
mesh_terms: D000328:Adult; D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077604:Fomepizole; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D000432:Methanol / Q000493:pharmacokinetics / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy; D011720:Pyrazoles / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D004791:Enzyme Inhibitors; D011720:Pyrazoles; D000077604:Fomepizole; D000426:Alcohol Dehydrogenase; D000432:Methanol