title: [Urinary excretion of cytokines in bladder carcinoma].
abstract: OBJECTIVE
  Analysis of the urinary excretion of cytokines in vesical carcinoma.
  
  
  METHODS
  The study includes the results obtained in the quantification of several interleukins (IL-1, IL-2, IL-4, IL-6, INF-gamma and TNF-alpha) in urine samples corresponding to 60 patients with transitional cell carcinoma (TCC) with vesical location (40 surface and 20 infiltrant). Concurrently, 40 healthy donors and 20 patients with urinary tract infections were studied. Determination of the various cytokines was done with ELISA enzyme-linked immunoassays.
  
  
  RESULTS
  The results obtained in the study show that: a) urinary concentrations of IL-1, IL-2, IL-6, TNF- and INF- in surface TCC, are similar to those found in healthy subjects; b) levels of the mentioned cytokines are significantly higher in patients with urinary infections; c) in patients with infiltrant TCC, IL-6 urinary concentration is significantly higher than in those with S-TCC; d) urinary IL-4 levels show no difference between the various groups under study.
  
  
  CONCLUSIONS
  From all the above it is concluded that there is a large diversity in the excretion of urinary cytokines from the vesical urothelium based on antigenic stimulation (bacterial or tumoral) to which it has been exposed and the tumoral stage, and that baseline determination of IL-6 urine level in patients with vesical TCC could have some prognostic influence.
authors.affiliation: Servicio de Urología, Clínica Puerta de Hierro, Madrid.
authors.forename: C
authors.initials: C
authors.lastname: Olivier Gómez
authors.forename: J A
authors.initials: JA
authors.lastname: Carballido Rodríguez
authors.forename: E
authors.initials: E
authors.lastname: Reyes Martín
authors.forename: A
authors.initials: A
authors.lastname: Hernández Lao
authors.forename: D
authors.initials: D
authors.lastname: López Bellido
authors.forename: L
authors.initials: L
authors.lastname: Menéndez Ondina
authors.forename: M
authors.initials: M
authors.lastname: Alvárez-Mon Soto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000652:urine*; D016207:Cytokines / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000652:urine*
chemical_list: D016207:Cytokines