title: Evolution of the dopaminergic system and its relationships with the psychopathology of pleasure.
abstract: This paper summarizes the fundamental steps in the evolution of the dopaminergic system. A rudimentary dopaminergic system is present in primitive creatures, already able to select information processing, modulate "emotional" behaviours and react to perturbations in environmental conditions. Pharmacological manipulations of the dopaminergic transmission are able to modify basic behaviours present in all animals from fishes to lizards to mammals. The ability to put the organism in motion and the hedonic capacity of giving pleasure, would justify the conservation through evolution of such a neuronal system. The fact however that the dopaminergic system has remained identical for the last several centuries, while many external conditions which interfere with its physiology have dramatically changed, may contribute to explain the transition from the original vital advantages of the dopaminergic system to its crucial role in the psychopathology of pleasure.
authors.affiliation: CNR Centre for Neuropharmacology, University of Cagliari, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pani
authors.forename: G L
authors.initials: GL
authors.lastname: Gessa
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D010990:Pleasure-Pain Principle; D011599:Psychopathology
chemical_list: D004298:Dopamine