Effect of glycerol on blood flow distribution in tumoral and peritumoral brain tissue.
To evaluate the effect of glycerol, thirty-two patients with brain tumor were directed to the study, including 17 gliomas and 15 meningiomas. Blood flow before and after the administration of glycerol were measured with Xe CT. Glioma was significantly hypo-perfused. The peritumoral edema of glioma and meningioma were also hypo-perfused. On the other hand, Meningioma was significantly hyper-perfused. After the administration of glycerol, blood flows were increased except for glioma. We suggested that, vascular responses to glycerol was different in the two tumor types. The steal phenomena of blood flow might occur in glioma.
Niwa
M
M
Department of Neurosurgery, Nakatsugawa General Municipal Hospital, Japan.
Oyama
H
H
Furuse
M
M
Takada
S
S
Kawai
T
T
Ishikawa
Y
Y
Kuchiwaki
H
H
Inao
S
S
Ichimi
K
K
Shibayama
M
M
D001932:Brain Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005910:Glioma / Q000098:blood supply / Q000188:drug therapy*; D005990:Glycerol / Q000627:therapeutic use*; D006801:Humans; D008577:Meningeal Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D008579:Meningioma / Q000098:blood supply / Q000188:drug therapy*
D005990:Glycerol