Nitroglycerin-induced hypoxemia does not produce myocardial ischemia.
OBJECTIVE
Nitroglycerin has been the drug of choice for relieving myocardial ischemia for more than a hundred years. Several studies have indicated that a significant reduction in arterial oxygen tension (PaO2) occurs after the administration of sublingual nitroglycerin to patients with coronary artery disease breathing room air. Because available oxygen in arterial blood is reduced, it would be reasonable to assume that oxygen delivery to the myocardium would also be impaired. The purpose of this study was to investigate whether nitroglycerin-induced arterial desaturation results in compromised oxidative metabolism of myocardium assessed by coronary sinus lactate concentration and oxygen content in patients with coronary artery disease undergoing coronary artery bypass surgery.


METHODS
Ten randomly selected patients undergoing coronary bypass surgery.


METHODS
All studies were performed at Siyami Ersek Cardiovascular and Thoracic Surgery Center.


METHODS
A catheter was inserted into the radial artery to measure blood gases and arterial lactate concentration. After sternotomy, and aortic and venous cannula placement, a coronary sinus catheter was introduced into the coronary sinus to measure oxygen content and lactate concentration. Control coronary sinus and arterial blood samples were obtained before nitroglycerin infusion. Nitroglycerin was then given in a dose of 2 micrograms/kg/min for a period of 5 minutes. At the end of 5 minutes, second samples were obtained from the coronary sinus and arterial catheters.


RESULTS
It was found that arterial and coronary sinus oxygen tension decreased significantly. Arterial lactate concentration did not change, coronary sinus lactate concentration decreased. Despite a substantial fall in arterial oxygen tension after administration of nitroglycerin, a significant reduction in coronary sinus lactate concentration occurred.


CONCLUSIONS
Nitroglycerin-induced hypoxia does not compromise oxidative metabolism of myocardium as can be assessed by a concomitant decrease in coronary sinus lactate concentration.
Toraman
F
F
Department of Anesthesiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul Turkey.
Kopman
E A
EA
Calişirişçi
U
U
Demirtaş
M
M
Bilgen
F
F
Ozler
A
A
Canik
S
S
Yiğiter
B
B
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000139:chemically induced*; D005996:Nitroglycerin / Q000009:adverse effects*; D014665:Vasodilator Agents / Q000009:adverse effects*
D014665:Vasodilator Agents; D005996:Nitroglycerin