title: In vivo NMR and MRI using injection delivery of laser-polarized xenon.
abstract: Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo 129Xe NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.
authors.affiliation: Lawrence Berkeley National Laboratory and University of California, Berkeley, CA 94720, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Goodson
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.forename: R E
authors.initials: RE
authors.lastname: Taylor
authors.forename: V D
authors.initials: VD
authors.lastname: Schepkin
authors.forename: K M
authors.initials: KM
authors.lastname: Brennan
authors.forename: G C
authors.initials: GC
authors.lastname: Chingas
authors.forename: T F
authors.initials: TF
authors.lastname: Budinger
authors.forename: G
authors.initials: G
authors.lastname: Navon
authors.forename: A
authors.initials: A
authors.lastname: Pines
mesh_terms: D006801:Humans; D007834:Lasers; D008168:Lung / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011859:Radiography; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes