Auditory evoked responses under total spinal anesthesia in rats.
In order to investigate the function of the auditory pathway from the cochlea to the brain stem under total spinal anesthesia, the auditory brain stem response (ABR), compound action potential of the cochlear nerve (CAP), and cochlear microphonics (CM) were simultaneously recorded in rats. Total spinal anesthesia was induced by infusion of 2% lidocaine hydrochloride at a constant rate of 0.10 mL/min into the cerebrospinal fluid through the rats' skulls. The ABR completely disappeared within 1.5 to 4 minutes. After cessation of the injection, the ABR reappeared, starting from wave I and progressing through waves II and III to wave IV. The latency change of the CAP throughout the recording period was quite similar to that of wave I of the ABR. A reduction in amplitude of the CM was observed, but the CM did not disappear during the recording period. Disappearance of the ABR was due, not to loss of cochlear function, but to anesthetic effects on the acoustic nerve and the brain stem. Monitoring of the ABR provided information on the level of neural activity in the brain stem under total spinal anesthesia.
Yamada
K
K
Department of Otolaryngology, Teikyo University School of Medicine, Tokyo, Japan.
Kaga
K
K
Sakata
H
H
Uno
A
A
Tsuzuku
T
T
D000200:Action Potentials / Q000187:drug effects; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects* / Q000134:cerebrospinal fluid; D000818:Animals; D001306:Auditory Pathways / Q000187:drug effects*; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D003056:Cochlear Nerve / Q000187:drug effects*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D016903:Drug Monitoring; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D008012:Lidocaine / Q000009:adverse effects* / Q000134:cerebrospinal fluid; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000779:Anesthetics, Local; D008012:Lidocaine