title: [Vaccination against hepatitis B in children with chronic hematologic diseases treated with immunosuppression].
abstract: Prevention of hepatitis B infection is an important factor in the successful management of cancer and aplastic anaemia cases. Our result suggested that children with Hodgkin's disease and solid tumors vaccinated during early stage of immunosuppressive therapy are good responders to hepatitis B vaccine. Active immunisation with hepatitis B vaccine (Engerix B), was also effective in children with leukaemia after completing immunosuppressive therapy. Protective levels of antibodies remained 6 years after vaccination. Vaccination according to shortened schedule (0-10-20 days) was not effective in these children. Passive immunisation is indicated in children with chronic neoplastic haematological diseases during immunosuppressive therapy. In 6 children the lack of seroconversion after vaccination was due to immune disorders.
authors.affiliation: Katedra i Klinika Pediatrii, Hematologii i Onkologii Akademii Medycznej w Warszawie.
authors.forename: T
authors.initials: T
authors.lastname: Jackowska
authors.forename: R
authors.initials: R
authors.lastname: Rokicka-Milewska
authors.forename: K
authors.initials: K
authors.lastname: Madaliński
authors.forename: E
authors.initials: E
authors.lastname: Kacperska
authors.forename: B
authors.initials: B
authors.lastname: Zupańska
authors.forename: K
authors.initials: K
authors.lastname: Muszyńska-Rosłan
authors.forename: M
authors.initials: M
authors.lastname: Kaczmarski
mesh_terms: D002648:Child; D005260:Female; D006402:Hematologic Diseases / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006509:Hepatitis B / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D007115:Immunization Schedule; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000276:immunology / Q000628:therapy
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines