BPC 157's effect on healing.
The 15 amino acid agent BPC 157, showing a wide range of organoprotective action in different experimental models, was used in our experiments in order to establish its influence on different elements connected with the healing process. Elements thought to be of greatest importance in the process of healing are formation of granulation tissue, angiogenesis and production of collagen. In our work we tested the influence of BPC 157 on: granulation tissue and collagen formation, on angiogenesis as well as on tensile strength development, using three experimental rat models: 1) skin incisional wounds; 2) colon-colon anastomoses; and 3) angiogenesis model with synthetic sponge implantation. The specimens were histologically assessed for collagen, reticulin and blood vessels using scoring and morphometry. In all experiments significant differences between BPC 157-treated animals and controls were found, showing a strong, promoting involvement of BPC in the healing process. It is worth noting that these effects were achieved by different routes of application, including intragastric and local, making BPC 157 a potentially useful therapeutic agent.
Seiwerth
S
S
Centre for Digestive Disease, Medical and Veterinary Faculty University of Zagreb, Croatia.
Sikiric
P
P
Grabarevic
Z
Z
Zoricic
I
I
Hanzevacki
M
M
Ljubanovic
D
D
Coric
V
V
Konjevoda
P
P
Petek
M
M
Rucman
R
R
Turkovic
B
B
Perovic
D
D
Mikus
D
D
Jandrijevic
S
S
Medvidovic
M
M
Tadic
T
T
Romac
B
B
Kos
J
J
Peric
J
J
Kolega
Z
Z
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001808:Blood Vessels / Q000254:growth & development / Q000502:physiology; D003094:Collagen / Q000378:metabolism; D003106:Colon / Q000293:injuries / Q000473:pathology; D003108:Colonic Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006097:Granulation Tissue / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D020007:Implants, Experimental; D008297:Male; D010446:Peptide Fragments / Q000627:therapeutic use*; D011506:Proteins / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012155:Reticulin / Q000378:metabolism; D012867:Skin / Q000293:injuries* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D000897:Anti-Ulcer Agents; D010446:Peptide Fragments; D011506:Proteins; D012155:Reticulin; C083833:BPC 157; D003094:Collagen