Genetics of sarcoidosis.
Hereditary susceptibility to sarcoidosis is suggested by ethnic preponderance, familial clustering, and multigenerational involvement. The genetics of sarcoidosis cannot be adequately addressed in small samples of patients; a large-scale study with stratification for patient phenotypic differences is necessary. A study that uses both genetic marker and environmental data would be able to control for and examine different causative mechanisms. Until such a well-designed, comprehensive study is carried out, we are left with interesting patterns of disease in families and uncertain allelic associations.
Rybicki
B A
BA
Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan, USA.
Maliarik
M J
MJ
Major
M
M
Popovich
J
J
Iannuzzi
M C
MC
D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D012507:Sarcoidosis / Q000235:genetics*
D006680:HLA Antigens