title: Embryonic expression of the mRNA for the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor.
abstract: We have previously cloned a human receptor recently shown to be a cofactor for entry of T-tropic HIV-1 strains into CD4+ cells, now named fusin. Stromal derived factor-1 (SDF-1) is an endogenous ligand for fusin, also called CXCR-4. Here we show the distribution of fusin/CXCR-4 mRNA during ontogeny in the rat. The onset of mRNA expression is around embryonic day 9 and the mRNA expression is high in the thymus as well as proliferative areas of the brain during development. Our results suggest: (1) that fusin/CXCR-4 might have a dual role in both brain development and the immune system; (2) that SDF-1 has a role in brain development or that additional physiological ligands exist for this receptor; (3) co-expression of CD4 and fusin/CXCR-4 may make fetuses susceptible to HIV infection during development.
authors.affiliation: Department of Medical Genetics, Uppsala University, Sweden. elena.jazin@medgen.uu.se
authors.forename: E E
authors.initials: EE
authors.lastname: Jazin
authors.forename: S
authors.initials: S
authors.lastname: Söderström
authors.forename: T
authors.initials: T
authors.lastname: Ebendal
authors.forename: D
authors.initials: D
authors.lastname: Larhammar
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology; D004622:Embryo, Mammalian / Q000378:metabolism*; D005314:Embryonic and Fetal Development / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000196:embryology; D009420:Nervous System / Q000196:embryology; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019718:Receptors, CXCR4 / Q000235:genetics*; D017385:Sequence Homology
chemical_list: D012333:RNA, Messenger; D019718:Receptors, CXCR4