Synthesis, DNA binding, and cleaving properties of an ellipticine-salen.copper conjugate.
The synthesis of a DNA-cutting agent that conjugates an ellipticine chromophore and a copper complex of bis(salicylidene)ethylenediamine, referred to as a salen, is reported. The presence of the salen.Cu complex allows cleavage of DNA via oxygen-based radicals, and the ellipticine moiety serves as a DNA anchor. Spectroscopic measurements indicate that the intercalation geometry of the ellipticine chromophore is preserved with the hybrid. The cleavage is much more efficient with the conjugate than with the Schiff base copper complex alone.
Routier
S
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Laboratoire de Chimie Organique Physique, URA 351 CNRS, USTL C3, Villeneuve d'Ascq, France.
Bernier
J L
JL
Catteau
J P
JP
Colson
P
P
Houssier
C
C
Rivalle
C
C
Bisagni
E
E
Bailly
C
C
D002614:Chelating Agents / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D002942:Circular Dichroism; D003300:Copper / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D004247:DNA / Q000187:drug effects* / Q000378:metabolism*; D004249:DNA Damage; D004611:Ellipticines / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D005029:Ethylenediamines / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D013053:Spectrophotometry
D002614:Chelating Agents; D004611:Ellipticines; D005029:Ethylenediamines; D009942:Organometallic Compounds; D003300:Copper; D004247:DNA; C011452:disalicylaldehyde ethylenediamine