Non-African Burkitt lymphoma presenting with oral thrush and an orbital mass in a child.
OBJECTIVE
To report an unusual case of orbital involvement with non-African Burkitt lymphoma in a child.


METHODS
A 26-month-old boy developed oral thrush and painless right proptosis with eyelid swelling. Magnetic resonance imaging disclosed a diffuse mass involving the inferior, lateral, and superior right orbit and both maxillary sinuses. Incisional biopsy of the orbital mass was performed.


RESULTS
Histopathology disclosed diffuse infiltration of the orbital tissues by a high-grade lymphoid neoplasm that showed positive immunoreactivity for B-cell markers. Immunoglobulin gene rearrangement studies disclosed a characteristic t(8;14) translocation consistent with a small, noncleaved malignant lymphoma of the Burkitt type.


CONCLUSIONS
Non-African Burkitt lymphoma may manifest with orbital involvement.
Edelstein
C
C
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Shields
J A
JA
Shields
C L
CL
De Potter
P
P
Eagle
R C
RC
Turtel
L
L
Hagstrom
N
N
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D002051:Burkitt Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D002180:Candidiasis, Oral / Q000150:complications / Q000175:diagnosis*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009918:Orbital Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed