title: Twenty-four hour growth hormone secretion in a patient with Werner's syndrome.
abstract: OBJECTIVE
  To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome.
  
  
  METHODS
  Blood sampling every 20 min for 24 h followed by three daily injections of growth hormone.
  
  
  METHODS
  General Clinical Research Center.
  
  
  METHODS
  Single patient with Werner's syndrome.
  
  
  METHODS
  Serum GH and IGF-I.
  
  
  RESULTS
  Growth hormone pulses were absent during the 24-h monitoring period. Likewise, integrated GH concentrations were very low at 0.25 mu min/mL, and no peaks occurred after sleep onset. Following single daily administration of rhGH, serum GH and IGF-I rose.
  
  
  CONCLUSIONS
  Our findings support previous but less extensive studies suggesting patients with Werner's syndrome have reduced growth hormone levels. Preliminary investigations using rhGH in patients with Werner's syndrome should be considered.
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235-8889, USA. crubin@mednet.swmed.edu
authors.forename: C D
authors.initials: CD
authors.lastname: Rubin
authors.forename: B
authors.initials: B
authors.lastname: Reed
mesh_terms: D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D014898:Werner Syndrome / Q000378:metabolism*
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone