[The forms of alcohol abuse and disorders of cardiovascular activity in the dynamics of the alcohol abstinence syndrome].
55 individuals were observed (41 patients with alcoholism and 14 healthy controls). The patients were divided into 2 groups: patients with permanent alcohol abuse (the 1-st), and patients with periodic alcohol taking (the 2-nd). Heart rate, systolic and diastolic arterial pressure were measured. Echocardiography was performed too. In the 1-st group disorders of myocardial relaxation were revealed in the structure of withdrawal syndrome with prevalence of blood flow in the phase of early left ventricular filling and moderate increase of contractility of the left ventricle. Asymptomatic course of alcohol withdrawal syndrome was quite characteristic for the first group too. In the 2-nd group (drinking, pseudodrinking alcoholism) there were disorders of myocardial relaxation with prevalence of blood flow in the late phase of left ventricular filling and moderate elevation of general contractility of the left ventricle. There were also complaints concerning disorders of cardiovascular circulation. It was revealed that alterations of cardiovascular activity in periodic form of alcohol administration manifested more pronouncedly during the first days of alcoholic withdrawal syndrome and disappeared more quickly as compared with permanent drinking. The usage of 3 groups of drugs in management of alcoholic withdrawal syndrome was grounded depending on the form of alcohol administration: drugs which increase the activity of cerebral inhibitory transmitters' systems; drugs which prevent increased activity of sympathoadrenal system; drugs which influence energetic and chemical homeostasis.
Polykovskiĭ
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AA
D000328:Adult; D000437:Alcoholism / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001794:Blood Pressure; D002319:Cardiovascular System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015150:Echocardiography, Doppler / Q000706:statistics & numerical data; D000431:Ethanol / Q000009:adverse effects*; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013997:Time Factors
D000431:Ethanol