title: Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
authors.forename: H G
authors.initials: HG
authors.lastname: Selnick
authors.forename: N J
authors.initials: NJ
authors.lastname: Liverton
authors.forename: J J
authors.initials: JJ
authors.lastname: Baldwin
authors.forename: J W
authors.initials: JW
authors.lastname: Butcher
authors.forename: D A
authors.initials: DA
authors.lastname: Claremon
authors.forename: J M
authors.initials: JM
authors.lastname: Elliott
authors.forename: R M
authors.initials: RM
authors.lastname: Freidinger
authors.forename: S A
authors.initials: SA
authors.lastname: King
authors.forename: B E
authors.initials: BE
authors.lastname: Libby
authors.forename: C J
authors.initials: CJ
authors.lastname: McIntyre
authors.forename: D A
authors.initials: DA
authors.lastname: Pribush
authors.forename: D C
authors.initials: DC
authors.lastname: Remy
authors.forename: G R
authors.initials: GR
authors.lastname: Smith
authors.forename: A J
authors.initials: AJ
authors.lastname: Tebben
authors.forename: N K
authors.initials: NK
authors.lastname: Jurkiewicz
authors.forename: J J
authors.initials: JJ
authors.lastname: Lynch
authors.forename: J J
authors.initials: JJ
authors.lastname: Salata
authors.forename: M C
authors.initials: MC
authors.lastname: Sanguinetti
authors.forename: P K
authors.initials: PK
authors.lastname: Siegl
authors.forename: D E
authors.initials: DE
authors.lastname: Slaughter
authors.forename: K
authors.initials: K
authors.lastname: Vyas
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured; D004285:Dogs; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009206:Myocardium / Q000166:cytology; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000502:physiology; D014981:Xenopus
chemical_list: D000081:Acetamides; D000889:Anti-Arrhythmia Agents; D001570:Benzodiazepinones; C109598:L 768673; D026902:Potassium Channel Blockers; D015221:Potassium Channels