title: [Immunochemical analysis of human monoclonal IGM with antibody cold agglutinin activity during Mycoplasma pneumoniae infection].
abstract: Mycoplasma pneumoniae (MP) infection is associated with the emergence of anti-I cold agglutinins of IgM isotype, rarely complicated by hemolytic anemia. The mechanism by which the autoimmune disease occurs is still considerably controversed. We describe here a case of MP infection complicated by severe autoimmune hemolytic anemia with monoclonal anti-I IgM. IgM anti-I antibodies were purified by adsorption-elution on OI+ red cells. The red blood cell antibodies were found to be tightly associated with IgG and anti-MP specificity probably as immune complexes. The significance of these results is discussed.
authors.affiliation: Laboratoire d'Hématologie et d'Immunopathologie, Faculté de Médecine de Tunis.
authors.forename: F
authors.initials: F
authors.lastname: Ben Aïssa-Fennira
authors.forename: A
authors.initials: A
authors.lastname: Bouguerra
authors.forename: R
authors.initials: R
authors.lastname: Hafsia
authors.forename: D
authors.initials: D
authors.lastname: Dellagi
authors.forename: A
authors.initials: A
authors.lastname: Ben Ammar-el Gaaied
authors.forename: K
authors.initials: K
authors.lastname: Dellagi
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000276:immunology*; D002648:Child; D003298:Coombs Test; D006801:Humans; D007120:Immunochemistry; D007075:Immunoglobulin M / Q000276:immunology*; D007525:Isoelectric Focusing; D008297:Male; D011019:Pneumonia, Mycoplasma / Q000150:complications* / Q000276:immunology*; D012680:Sensitivity and Specificity
chemical_list: D007075:Immunoglobulin M