Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver.
The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.
Meier
P J
PJ
Department of Medicine, University Hospital, Zürich, Switzerland.
Eckhardt
U
U
Schroeder
A
A
Hagenbuch
B
B
Stieger
B
B
D000818:Animals; D027321:Anion Transport Proteins; D000838:Anions / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D003001:Cloning, Molecular; D006801:Humans; D008099:Liver / Q000378:metabolism*; D026901:Membrane Transport Proteins; D008958:Models, Molecular; D029363:Organic Anion Transporters, Sodium-Dependent; D051381:Rats; D013379:Substrate Specificity; D027981:Symporters
D027321:Anion Transport Proteins; D000838:Anions; D001647:Bile Acids and Salts; D002352:Carrier Proteins; D026901:Membrane Transport Proteins; D029363:Organic Anion Transporters, Sodium-Dependent; D027981:Symporters; C071908:sodium-bile acid cotransporter