title: Multifeature analysis of Gd-enhanced MR images of breast lesions.
abstract: The objective of this study was to determine whether linear discriminant analysis of different independent features of MR images of breast lesions can increase the sensitivity and specificity of this technique. For MR images of 23 benign and 20 malignant breast lesions, three independent classes of features, including characteristics of Gd-DTPA-uptake curve, boundary, and texture were evaluated. The three classes included five, four and eight features each, respectively. Discriminant analysis was applied both within and across the three classes, to find the best combination of features yielding the highest classification accuracy. The highest specificity and sensitivity of the different classes considered independently were as follows: Gd-uptake curves, 83% and 70%; boundary features, 86% and 70%; and texture, 70% and 75%, respectively. A combination of one feature each from the first two classes and age yielded a specificity of 79% and sensitivity of 90%, whereas highest figures of 93% and 95%, respectively, were obtained when a total of 10 features were combined across different classes. Statistical analysis of different independent classes of features in MR images of breast lesions can improve the classification accuracy of this technique significantly.
authors.affiliation: Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA 90095-1721, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: F A
authors.initials: FA
authors.lastname: Lucas-Quesada
authors.forename: N D
authors.initials: ND
authors.lastname: DeBruhl
authors.forename: J
authors.initials: J
authors.lastname: Sayre
authors.forename: D
authors.initials: D
authors.lastname: Farria
authors.forename: D P
authors.initials: DP
authors.lastname: Gorczyca
authors.forename: L W
authors.initials: LW
authors.lastname: Bassett
mesh_terms: D001941:Breast Diseases / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D003627:Data Interpretation, Statistical; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA