Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.
The hypothesis that chromosomal fragile sites may be "weak links" that result in hot spots for cancer-specific chromosome rearrangements was supported by the discovery that numerous cancer cell homozygous deletions and a familial translocation map within the FHIT gene, which encompasses the common fragile site, FRA3B. Sequence analysis of 276 kb of the FRA3B/FHIT locus and 22 associated cancer cell deletion endpoints shows that this locus is a frequent target of homologous recombination between long interspersed nuclear element sequences resulting in FHIT gene internal deletions, probably as a result of carcinogen-induced damage at FRA3B fragile sites.
Inoue
H
H
Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107, USA.
Ishii
H
H
Alder
H
H
Snyder
E
E
Druck
T
T
Huebner
K
K
Croce
C M
CM
D017766:Acid Anhydride Hydrolases; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D017353:Gene Deletion; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D011506:Proteins / Q000235:genetics*; D011995:Recombination, Genetic; D014407:Tumor Cells, Cultured; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D011506:Proteins; D000099170:Bis(5'-adenosyl)triphosphatase