In pursuit of drugs for American trypanosomiasis: evaluation of some "standards" in a mouse model.
Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective as the reference drug, nifurtimox. A major value of the present data is to demonstrate the refractoriness of the T. cruzi parasite against many of the drug standards that have known biological activity.
Kinnamon
K E
KE
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA.
Poon
B T
BT
Hanson
W L
WL
Waits
V B
VB
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D004195:Disease Models, Animal; D005260:Female; D007099:Imipramine / Q000737:chemistry / Q000627:therapeutic use; D007654:Ketoconazole / Q000627:therapeutic use; D051379:Mice; D008815:Mice, Inbred Strains; D009547:Nifurtimox / Q000627:therapeutic use; D009550:Nigericin / Q000627:therapeutic use; D009560:Niridazole / Q000627:therapeutic use; D011530:Protriptyline / Q000737:chemistry / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
D000981:Antiprotozoal Agents; D011530:Protriptyline; D009547:Nifurtimox; D009560:Niridazole; D007099:Imipramine; D007654:Ketoconazole; D009550:Nigericin