title: Relationships between changes in symptom ratings, neurophysiological test performance and quality of life in schizophrenic patients treated with clozapine.
abstract: This study examined the correlations between reduction in symptoms, changes in neuropsychological test performance and improved quality of life in 19 schizophrenic outpatients treated with clozapine. Reduction in both negative symptoms and general psychopathology was associated with a better quality of life. Some improvement in neuropsychological test performance was found, with a variable pattern of association with change in psychopathology. Improved verbal fluency was associated with reduction in negative symptoms, while improved verbal concept formation was associated with reduction in positive symptoms.
authors.affiliation: Department of Psychiatry, University of Adelaide, The Queen Elizabeth Hospital, Woodville, S.A., Australia.
authors.forename: C A
authors.initials: CA
authors.lastname: Galletly
authors.forename: C R
authors.initials: CR
authors.lastname: Clark
authors.forename: A C
authors.initials: AC
authors.lastname: McFarlane
authors.forename: D L
authors.initials: DL
authors.lastname: Weber
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D011594:Psychometrics; D011788:Quality of Life; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012564:Schizophrenic Language; D012565:Schizophrenic Psychology; D016896:Treatment Outcome; D014705:Verbal Behavior / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine