Progressive myoclonus epilepsy in young adults with neuropathologic features of Alzheimer's disease.
Progressive myoclonus epilepsy (PME) may develop in adult life. We present two patients with PME appearing around the age of 30 years in whom the disorder represented a manifestation of Alzheimer's disease. This diagnosis must be considered in addition to possible Kufs' disease or myoclonic epilepsy with ragged red fibers (MERRF) when PME develops in young adults.
Melanson
M
M
Department of Neurology and Neurosurgery, McGill University and Montreal Neurological Institute, Quebec, Canada.
Nalbantoglu
J
J
Berkovic
S
S
Melmed
C
C
Andermann
E
E
Roberts
L J
LJ
Carpenter
S
S
Snipes
G J
GJ
Andermann
F
F
D000328:Adult; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D004831:Epilepsies, Myoclonic / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male