The measurement of R2, R2* and R2' in HIV-infected patients using the prime sequence as a measure of brain iron deposition.
Brain iron deposition was assessed at 1.5 T in the caudate nucleus, globus pallidus and frontal and parieto-occipital white matter in 28 human immunodeficiency virus (HIV)-infected patients and 15 control subjects with a new Partially Refocussed Interleaved Multi-Echo sequence by measuring 1/T2, 1/T2* and 1/T2' (i.e., R2, R2* and R2'). There were significant differences in the R2 and R2* of the caudate nucleus (p < 0.0001 and p < 0.05) and the R2, R2* and R2' of the globus pallidus (p < 0.01, p < 0.005 and p < 0.05) in HIV-infected patients compared to control subjects. There was a trend for higher values of R2, R2* and R2' in the globus pallidus and caudate nucleus in HIV-infected patients with later stage HIV disease. These results suggest that there is greater iron deposition in the basal ganglia of HIV-infected patients compared with control subjects, with a predilection for the globus pallidus. The relationship between iron deposition in the brain and various parameters of severity of HIV infection remains uncertain.
Miszkiel
K A
KA
Department of Radiology at UCL Hospitals (NHS) Trust, London, UK. kathm@medphys.ucl.ac.uk
Paley
M N
MN
Wilkinson
I D
ID
Hall-Craggs
M A
MA
Ordidge
R
R
Kendall
B E
BE
Miller
R F
RF
Harrison
M J
MJ
D015526:AIDS Dementia Complex / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D001479:Basal Ganglia / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D018791:CD4 Lymphocyte Count; D002421:Caudate Nucleus / Q000378:metabolism / Q000473:pathology; D005260:Female; D005917:Globus Pallidus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male
D007501:Iron