Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo.
Angiostatin inhibits angiogenesis and metastatic tumor growth; however, its usefulness in treating primary nonmetastasizing tumors is less well understood. We now report the effectiveness of human angiostatin administration in a mouse hemangioendothelioma model. Human angiostatin was administered to mice with s.c. hemangioendothelioma and associated disseminated intravascular coagulopathy (Kasabach-Merritt syndrome). Angiostatin significantly reduced tumor volume in comparison to nontreated controls, increased survival, and prevented the profound thrombocytopenia and anemia of Kasabach-Merritt syndrome. Apoptosis of tumor cells was induced by angiostatin, but tumor cell proliferation was not inhibited. These data suggest angiostatin as a novel treatment for nonmetastasizing vascular tumors and for Kasabach-Merritt syndrome.
Lannutti
B J
BJ
Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Gately
S T
ST
Quevedo
M E
ME
Soff
G A
GA
Paller
A S
AS
D000740:Anemia / Q000517:prevention & control*; D043168:Angiostatins; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006390:Hemangioendothelioma / Q000188:drug therapy* / Q000473:pathology*; D006391:Hemangioma / Q000517:prevention & control*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D010446:Peptide Fragments / Q000096:biosynthesis / Q000627:therapeutic use*; D010958:Plasminogen / Q000096:biosynthesis / Q000627:therapeutic use*; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013577:Syndrome; D013921:Thrombocytopenia / Q000517:prevention & control*
D000970:Antineoplastic Agents; D010446:Peptide Fragments; D043168:Angiostatins; D010958:Plasminogen