Interstitial cystitis and bladder mastocytosis in a woman with chronic urticaria.
A patient with chronic urticaria and angioedema developed endoscopically confirmed interstitial cystitis. Bladder biopsy revealed bladder mastocytosis with > 60 mast cells/mm2 (normal < 10) in the detrusor and submucosa. Most of the mast cells were activated and degranulated. The occurrence of IC in a patient with urticaria and angioedema, diseases both associated with mast cell pathophysiology, supports the role of mast cells in interstitial cystitis.
Sant
G R
GR
Department of Urology, Tufts University School of Medicine, New England Medical Center Hospitals, Boston, MA 02111, USA.
Theoharides
T C
TC
Letourneau
R
R
Gelfand
J
J
D000328:Adult; D001706:Biopsy; D015550:Cell Degranulation; D018856:Cystitis, Interstitial / Q000473:pathology*; D005260:Female; D006801:Humans; D008407:Mast Cells / Q000473:pathology / Q000502:physiology*; D008415:Mastocytosis / Q000473:pathology*; D001743:Urinary Bladder / Q000473:pathology*; D014581:Urticaria / Q000473:pathology*