[The characteristics of catecholamine metabolism in patients in the initial stage of hypertension].
Catecholamines metabolism (24-h excretion, circadian rhythm of DOPA, dopamine, homovanillic acid, adrenaline, noradrenaline, vanilmandelic acid) was investigated in 124 young males with stage I essential hypertension treated by cranial electrostimulation. Relative activity of this metabolism stages was assessed. Patients with early stages of essential hypertension seem to have enhanced secretory and metabolic activity of the sympathetic link of the sympathoadrenal system with associated dopamine dysbolism; relative deficiency of dopaminergic system with activation of dopamine conversion to homovanillic acid in its intact conjugation. It is suggested that a marked increase of the ratio noradrenaline/dopamine may serve a biochemical marker of essential hypertension and risk of the disease progression.
Makolkin
V I
VI
Podzolkov
V I
VI
Bol'shakova
T D
TD
D000328:Adult; D002395:Catecholamines / Q000652:urine*; D002940:Circadian Rhythm; D003131:Combined Modality Therapy; D004039:Diet, Sodium-Restricted; D018450:Disease Progression; D004599:Electric Stimulation Therapy; D006801:Humans; D006973:Hypertension / Q000628:therapy / Q000652:urine*; D008297:Male; D012307:Risk Factors
D002395:Catecholamines