title: Amantadine does not have antiviral activity against Borna disease virus.
abstract: We have investigated the antiviral activity of amantadine (AD) against Borna disease virus (BDV) in several culture cell systems. We present evidence that AD, in the range 5 to 10 microM, does not have antiviral activity against BDV. Treatment of BDV infected cells with AD for six days caused neither a reduction in the number of infected cells, nor a decrease in steady state levels of BDV RNA or proteins. Moreover, treatment of cells with AD prior infection did not affect BDV multiplication, whereas influenza A virus yield was less than 1% with respect to that obtained in untreated control cells.
authors.affiliation: Department of Neuropharmacology, Scripps Research Institute, La Jolla, California, USA.
authors.forename: B
authors.initials: B
authors.lastname: Cubitt
authors.forename: J C
authors.initials: JC
authors.lastname: de la Torre
mesh_terms: D000547:Amantadine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D000956:Antigens, Viral / Q000378:metabolism; D000998:Antiviral Agents / Q000494:pharmacology*; D001891:Borna disease virus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D004285:Dogs; D012367:RNA, Viral / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents; D012367:RNA, Viral; D014764:Viral Proteins; C077347:p40 protein, Borna disease virus; D000547:Amantadine