title: Malignant lymphoma of the transverse colon associated with macroglobulinemia.
abstract: We present an unusual case of a malignant lymphoma of the transverse colon associated with macroglobulinemia. A 73-yr-old man was incidentally discovered to have high serum gamma-globulin on a regular check-up. Serum immunoquantitation revealed an IgM level of 3490 mg/dl. Kappa-type Bence-Jones protein was positive in the urine. Immunoelectrophoresis identified the abnormal protein as IgM-kappa. After hospitalization an abdominal tumor was detected with barium and CT, identified as a tumor of the transverse colon. Partial resection of the transverse colon was carried out. Histopathologically the tumor were confirmed as small lymphocytic non-Hodgkin lymphoma of B-cell origin, based on the Working Formulation. According to flowcytometric analysis, the tumor cells were positive for IgM-kappa. The lymphoma cells produced monoclonal IgM, giving rise to macroglobulinemia.
authors.affiliation: Akita Rosai Hospital and Department of Pathology of the University of Akita, School of Medicine, Oodate City, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Yasui
authors.forename: F
authors.initials: F
authors.lastname: Tukamoto
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Yagisawa
authors.forename: A
authors.initials: A
authors.lastname: Uno
authors.forename: H
authors.initials: H
authors.lastname: Nanjo
mesh_terms: D000368:Aged; D001466:Barium Sulfate; D003082:Colectomy; D003110:Colonic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery; D003287:Contrast Media; D005434:Flow Cytometry; D006801:Humans; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000097:blood / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism / Q000652:urine; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000601:surgery; D008297:Male; D014057:Tomography, X-Ray Computed; D008258:Waldenstrom Macroglobulinemia / Q000209:etiology*
chemical_list: D003287:Contrast Media; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D001466:Barium Sulfate