Prediction of effect of interferon on chronic hepatitis C.
Clinical, pathological, and virological analysis including hypervariable region-1 of hepatitis C virus (HCV) was performed to predict the effect of interferon (IFN) on 41 patients with chronic hepatitis type C. The low virus load, low frequency of the mutation in the hypervariable region-1 as the change of amino acid and high level of serum aminotransferase make one estimate the good effect of IFN on patients with HCV. Mutation in the hypervariable region-1 of HCV measured by fast assay fluorescence single-stranded conformational polymorphism was more frequent in nonresponders to IFN than responders. The most frequently mutated position was amino acid number 406. This indicates that the specific mutation site might affect the response of IFN.
Takagi
H
H
First Department of Internal Medicine, Gunma University School of Medicine, Japan.
Takehara
K
K
Shimoda
R
R
Kakizaki
S
S
Takayama
H
H
Abe
T
T
Yamada
T
T
Hashimoto
Y
Y
Saitoh
S
S
Matsumoto
T
T
Kojima
A
A
Takezawa
J
J
Yuasa
K
K
Moriguchi
M
M
Sekiguchi
T
T
Nagamine
T
T
Mori
M
M
D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D005453:Fluorescence; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D007135:Immunoglobulin Variable Region; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D018807:Polymorphism, Single-Stranded Conformational; D017421:Sequence Analysis; D000637:Transaminases / Q000097:blood; D019562:Viral Load
D000998:Antiviral Agents; D007135:Immunoglobulin Variable Region; D016898:Interferon-alpha; D000637:Transaminases