title: Localized unilateral periorbital edema induced by aspirin.
abstract: BACKGROUND
  Aspirin intolerance manifested as bronchospasm or urticaria/angioedema has been observed since the beginning of this century.
  
  
  OBJECTIVE
  To report a novel case of intolerance to aspirin ingestion.
  
  
  METHODS
  Case report; routine skin testing; pulmonary function testing; aspirin challenge.
  
  
  RESULTS
  A 30-year-old man with a history of left ocular trauma at the age of 10 noted a 3-year history of left periorbital angioedema after aspirin but not other nonsteroidal anti-inflammatory drugs. Incremental oral aspirin challenge resulted in this unilateral symptomatology at a dose of 673 mg.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first reported case of unilateral periorbital edema following aspirin ingestion.
authors.affiliation: Department of Medicine, Montreal General Hospital, McGill University.
authors.forename: K S
authors.initials: KS
authors.lastname: Price
authors.forename: D M
authors.initials: DM
authors.lastname: Thomson
mesh_terms: D000328:Adult; D000799:Angioedema / Q000139:chemically induced*; D001241:Aspirin / Q000009:adverse effects*; D004361:Drug Tolerance / Q000276:immunology / Q000502:physiology; D006801:Humans; D008297:Male; D009916:Orbital Diseases / Q000139:chemically induced*
chemical_list: D001241:Aspirin