Development of systemic lupus erythematosus in a rheumatoid arthritis patient with anti-ribosomal P protein antibody.
We describe a patient with rheumatoid arthritis (RA) whose sera contained a high titre of an antibody targeting cytoplasmic ribosomal P proteins (anti-P). This association preceded by 6 years the development of serological and clinical manifestations of systemic lupus erythematosus (SLE). The clinical significance of anti-P for the diagnosis of SLE is discussed.
Hamasaki
K
K
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Mimura
T
T
Kanda
H
H
Morino
N
N
Yazaki
Y
Y
Nojima
Y
Y
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000276:immunology; D015800:Protozoan Proteins; D012269:Ribosomal Proteins / Q000276:immunology*
D001323:Autoantibodies; C064601:L12E protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D012269:Ribosomal Proteins