title: Effect of Gasex on pharmacokinetic profile of ciprofloxacin in healthy male volunteers.
abstract: Effect of Gasex, a herbomineral formulation on the bioavailability of ciprofloxacin was studied in six healthy male volunteers. On day one, single dose of ciprofloxacin (500 mg) was given at fasting state and the plasma Concentrations of ciprofloxacin were estimated after 1, 2 and 4 hr. On day 8 ciprofloxacin (500 mg) was given along with 2 tablets of Gasex and the plasma concentrations of ciprofloxacin estimated at the same time points. No significant difference in the plasma ciprofloxacin levels was found in these two treatments, indicating that the bioavailability of ciprofloxacin was not affected by simultaneous treatment with Gasex.
authors.affiliation: R & D Centre, Himalaya Drug Co., Makali, Bangalore, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Mitra
authors.forename: R
authors.initials: R
authors.lastname: Sundaram
mesh_terms: D000328:Adult; D001682:Biological Availability; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D012016:Reference Values
chemical_list: D004338:Drug Combinations; C110500:Gasex; D010936:Plant Extracts; D002939:Ciprofloxacin