Synthesis and antibacterial activities of some new arenesulfonamides and urea derivatives.
Reactions of 3-substituted-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones [I] with some arenesulfonyl chlorides and aryl isocyanates were studied and the corresponding N-(3-substituted-4,5,-dihydro-1H-1,2,4-triazol-5-one-4-yl) arenesulfonamides [II-VI] and N-aryl-N-(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl) ureas [V, VI] were obtained. The structural assignments of new 19 compounds are based on spectral data and elemental analysis. Furthermore, compounds II-VI were tested for their in vitro antimicrobial activities.
Doğan
N
N
Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
Ikizler
A
A
Johansson
C B
CB
Ikizler
A A
AA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D017953:Isocyanates / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009282:Naphthalenesulfonates / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology; D014508:Urea / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D017953:Isocyanates; D009282:Naphthalenesulfonates; D013449:Sulfonamides; D014508:Urea