Severe haemorrhagic diathesis in an adult patient with cystic fibrosis after long-term antibiotic treatment of pulmonary infection.
We describe the case of a 22 yr old male patient with cystic fibrosis, who, after long-term antibiotic treatment of pulmonary infection, developed a haemorrhagic diathesis with severe bleeding from the mucus membrane of the mouth, and haematuria. Rapid recovery was observed after infusion of vitamin K. During 8 months of follow-up, no evidence of recurrence of the clotting disturbances and anaemia were noted. The combination of impaired absorption of vitamin K due to underlying disease with the antibiotic-induced suppression of vitamin K synthesis by intestinal bacteria could be a possible explanation for this disorder.
Nowak
D
D
Dept of Pneumology and Allergology, Medical University of Lodz, Poland.
Chudzik
J
J
Pietras
T
T
Bialasiewicz
P
P
D000328:Adult; D002444:Cefuroxime / Q000009:adverse effects* / Q000627:therapeutic use; D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications* / Q000188:drug therapy; D005500:Follow-Up Studies; D005839:Gentamicins / Q000009:adverse effects* / Q000627:therapeutic use; D006474:Hemorrhagic Disorders / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D009428:Netilmicin / Q000009:adverse effects* / Q000627:therapeutic use; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D013997:Time Factors; D014812:Vitamin K / Q000627:therapeutic use
D002511:Cephalosporins; D005839:Gentamicins; D014812:Vitamin K; D009428:Netilmicin; D002444:Cefuroxime