title: The effect of age and diet on the oral glucose tolerance test in ponies.
abstract: To evaluate the effects of age and diet on the oral glucose tolerance test (OGTT) in healthy ponies, OGTTs were performed on 2 groups of British native breed ponies (Group A: 7 foals [6-9 months], Group B: 7 mature individuals [6-13 years]) when maintained on either a high fibre pelleted ration only (Groups A and B) or a hay only diet (Group B). Plasma glucose response, following oral glucose administration, for Group A (basal plasma glucose concentration [Glu0] 4.6 +/- 0.4 mmol/l (mean +/- s.d.) increasing to 11.5 +/- 1.3 mmol/l at 90 min) was significantly different (P < 0.05) from that observed for Group B (Glu0 of 4.3 +/- 0.2 mmol/l increasing to 6.8 +/- 1.3 mmol/l at 90 min), when fed the same diet. For Group B ponies, the plasma glucose response, following oral glucose administration, was significantly different (P < 0.05) when fed hay only (Glu0 4.6 +/- 0.4 mmol/l increasing to 9.6 +/- 2.1 mmol/l at 150 min) compared to when fed the high fibre pelleted ration. These results indicate that both age and diet have a significant effect on plasma glucose concentrations measured during an OGTT.
authors.affiliation: Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, UK.
authors.forename: D
authors.initials: D
authors.lastname: Murphy
authors.forename: S W
authors.initials: SW
authors.lastname: Reid
authors.forename: S
authors.initials: S
authors.lastname: Love
mesh_terms: D000375:Aging / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D004032:Diet / Q000662:veterinary*; D004043:Dietary Fiber / Q000494:pharmacology; D005951:Glucose Tolerance Test / Q000379:methods / Q000662:veterinary*; D006736:Horses / Q000097:blood* / Q000378:metabolism / Q000502:physiology
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber