HLA-DQB1 markers associated with human immunodeficiency virus type I disease progression.
In a previous investigation, we demonstrated that certain human leukocyte antigens (HLA) may be associated with human immunodeficiency virus type I (HIV-1) infection or protection from infection among regional African Americans and Caucasians. We demonstrated that HLA-DQB1*0605 was associated with a possible increased risk of susceptibility to infection in African Americans and that DQB1*0602 was associated with a possible increased risk of infection in Caucasians. The present study was designed to demonstrate possible HLA associations with HIV-1 disease progression and AIDS in regional African American and Caucasian populations. To differentiate rapid from slow progressors, immune parameters of the HIV-1-positive patient population were monitored over a mean follow-up period of 23 +/- 2 months for African Americans (n = 30) and 25 +/- 5 months for Caucasians (n = 22). To determine significance, HLA allele frequencies among rapid progressors were compared to those of slow progressors, separated by race. Results were analyzed by chi 2 analysis, with Fisher's exact test where applicable, linear logistic regression and Kaplan-Meier survival analysis. In the HIV-1-positive African American group, a better prognosis was associated with HLA-DQB1*0602. In the HIV-1-positive Caucasian group, HLA-DQB1*0302 was associated with rapid HIV disease progression, but no marker was associated with a more favorable prognosis.
Achord
A P
AP
Department of Pathology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
Lewis
R E
RE
Brackin
M N
MN
Cruse
J M
JM
D000293:Adolescent; D000328:Adult; D000483:Alleles; D044383:Black People / Q000235:genetics*; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D018450:Disease Progression; D005819:Genetic Markers / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000401:mortality*; D015497:HIV-1 / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006239:Haplotypes; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D044465:White People / Q000235:genetics*; D001741:Black or African American
D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen