About-half-weekly (circasemiseptan) component of the endothelin-1 (ET-1) chronome and vascular disease risk.
Plasma ET-1 was measured around the clock on different calendar dates in healthy subjects and in subjects with diabetes and/or with high blood pressure and/or a history of vascular complications (HVDR). A transverse approach, with each subject contributing a single 24-h mean, assessed any about-weekly or half-weekly variation in ET-1. A circasemiseptan component resolved by single cosinor for nondiabetic (but not for diabetic) HVDR subjects (p = 0.010) differs in its timing of overall high values (p < 0.050) from that found in healthy subjects (p = 0.006). The results are aligned with circasemiseptan patterns in other circulatory variables and morbidity/mortality statistics.
Tarquini
B
B
University of Minnesota, Department of Laboratory Medicine and Pathology, Lyon Laboratories, Minneapolis 55455, USA.
Cornélissen
G
G
Perfetto
F
F
Tarquini
R
R
Halberg
F
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000097:blood; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010507:Periodicity; D012307:Risk Factors; D014652:Vascular Diseases / Q000097:blood / Q000401:mortality*
D019332:Endothelin-1