Integrin cytoplasmic domains as connectors to the cell's signal transduction apparatus.
Integrins mediate the bidirectional transfer of signals across the plasma membrane. Integrin cytoplasmic domains provide one pathway linking integrin engagement with the cell's signal transduction apparatus. Recent structure-function studies have defined regions of beta cytoplasmic domains required for integrin function and have identified distinct roles for individual alpha cytoplasmic domains in regulating cell behavior. Newly identified proteins that bind to integrin alpha and beta cytoplasmic domains have provided new insights and new questions into the mechanisms involved in integrin signaling.
LaFlamme
S E
SE
Department of Physiology and Cell Biology, Albany Medical College, New York, USA.
Homan
S M
SM
Bodeau
A L
AL
Mastrangelo
A M
AM
D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000502:physiology; D018821:CD18 Antigens / Q000502:physiology; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D019012:Integrin beta1 / Q000502:physiology; D039661:Integrin beta3; D039663:Integrin beta4; D016023:Integrins / Q000502:physiology*; D008969:Molecular Sequence Data; D016296:Mutagenesis; D010766:Phosphorylation; D010980:Platelet Membrane Glycoproteins / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction
D015703:Antigens, CD; D018821:CD18 Antigens; D019012:Integrin beta1; D039661:Integrin beta3; D039663:Integrin beta4; D016023:Integrins; D010980:Platelet Membrane Glycoproteins; D011505:Protein-Tyrosine Kinases