title: Surgical chemotherapy in the management of melanoblastoma of the lower extremities.
abstract: The therapy of advanced melanoblastomas of the lower extremities is limited. Surgery alone is insufficient due to the extent of the tumor, the radicality of mutilating surgery is questionable because of the existing or suspected subclinical metastasis. To avoid amputation, regional chemoperfusion and simultaneous hemofiltration may be the choice of treatment. Between 1993 and 1995 the authors performed surgical chemotherapy on 21 occasions in 14 patients with advanced melanoblastoma of the lower limb. Partial remission of 4 to 11 months developed in 10 patients, 3 patients achieved subjective improvement for 3 to 6 months, 1 patient had disease progression. Simultaneous application of surgical regional chemotherapy and hemofiltration offers an alternative approach in the management of patients suffering from advanced melanoblastoma.
authors.affiliation: Department of Surgery, National Institute of Oncology, Budapest, Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Rahóty
authors.forename: I
authors.initials: I
authors.lastname: Besznyák
authors.forename: V
authors.initials: V
authors.lastname: Erdélyi-Tóth
authors.forename: Z
authors.initials: Z
authors.lastname: Sulvok
authors.forename: G
authors.initials: G
authors.lastname: Péley
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005500:Follow-Up Studies; D006440:Hemofiltration; D006801:Humans; D007261:Infusions, Intra-Arterial; D007866:Leg / Q000601:surgery; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000903:Antibiotics, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D004317:Doxorubicin; D008558:Melphalan