title: Genetics of sarcoidosis.
abstract: Hereditary susceptibility to sarcoidosis is suggested by ethnic preponderance, familial clustering, and multigenerational involvement. The genetics of sarcoidosis cannot be adequately addressed in small samples of patients; a large-scale study with stratification for patient phenotypic differences is necessary. A study that uses both genetic marker and environmental data would be able to control for and examine different causative mechanisms. Until such a well-designed, comprehensive study is carried out, we are left with interesting patterns of disease in families and uncertain allelic associations.
authors.affiliation: Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Rybicki
authors.forename: M J
authors.initials: MJ
authors.lastname: Maliarik
authors.forename: M
authors.initials: M
authors.lastname: Major
authors.forename: J
authors.initials: J
authors.lastname: Popovich
authors.forename: M C
authors.initials: MC
authors.lastname: Iannuzzi
mesh_terms: D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D012507:Sarcoidosis / Q000235:genetics*
chemical_list: D006680:HLA Antigens