Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome.
Viral infections are thought to play a part in some cutaneous drug reactions. Human herpesvirus 6 (HHV6), which is the agent of exanthema subitum (sixth disease), has never been implicated in a drug reaction. We report a patient with severe phenobarbital-induced anticonvulsant hypersensitivity syndrome in whom a fulminant haemophagocytic syndrome was associated with HHV6 infection. We discuss the possible role of HHV6 in this reactive condition.
Descamps
V
V
Service de dermatologie, Hôpital Bichat, Paris, France.
Bouscarat
F
F
Laglenne
S
S
Aslangul
E
E
Veber
B
B
Descamps
D
D
Saraux
J L
JL
Grange
M J
MJ
Grossin
M
M
Navratil
E
E
Crickx
B
B
Belaich
S
S
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000821:virology*; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D015654:Herpesvirus 6, Human; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology / Q000821:virology*; D006801:Humans; D010634:Phenobarbital / Q000009:adverse effects*; D013577:Syndrome
D000927:Anticonvulsants; D010634:Phenobarbital