Interaction of diet and genes in atherogenesis. Report of an NHLBI working group.
Recent advances in genetics and information emerging from the Human Genome Project make it feasible to examine the importance of dietary-genetic interactions in the development of atherosclerosis. In the opinion of the Working Group, three approaches are necessary to examine this concern. The first approach utilizes animal models to map and identify candidate genes involved in dietary responsiveness and atherogenesis. The second approach involves the evaluation of these genes in specific physiological processes involved in dietary responsiveness and atherogenesis. Finally, the third approach is to extend the studies performed in animal models to human populations using linkage or association studies.
Tall
A
A
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA.
Welch
C
C
Applebaum-Bowden
D
D
Wassef
M
M
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000235:genetics; D004032:Diet / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D006292:Health Priorities; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000235:genetics; D008660:Metabolism / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009316:National Institutes of Health (U.S.); D051381:Rats; D014481:United States
D004041:Dietary Fats