Comutagenesis-I: the in vitro metabolism of 2-amino-3-methylpyridine.
The metabolism of the comutagen 2-amino-3-methylpyridine has been studied in vitro using rat and rabbit hepatic preparations. 2-Amino-3-methylpyridine-N-oxide, 2-amino-3-hydroxymethylpyridine and 2-amino-5-hydroxy-3-methylpyridine were formed by both rat and rabbit hepatic preparations. No evidence was obtained for the formation of the corresponding 2-hydroxylamine, 2-nitroso, 2-nitro-3-methyl-pyridine or their condensation products i.e. azo, azoxy or hydrazo. The results are discussed in relation to the possible mechanism of action of the substrate.
Altuntas
T G
TG
Chelsea Department of Pharmacy, King's College London, University of London, U.K.
Manson
D
D
Zhao
K
K
Gorrod
J W
JW
D000631:Aminopyridines / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D008099:Liver / Q000378:metabolism; D009153:Mutagens / Q000378:metabolism*; D010084:Oxidation-Reduction; D010847:Picolines / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D000631:Aminopyridines; D009153:Mutagens; D010847:Picolines; C109727:2-amino-3-methylpyridine