title: Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes.
abstract: Dihomogammalinolenic acid is derived from gammalinolenic acid, administration of which suppresses joint inflammation. It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide. Effects of eicosapentaenoic acid (EPA) on IL-1beta production are minimal, and palmitic acid (PA) does not influence IL-1beta production.
authors.affiliation: Rheumatology Division, Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01655-0335, USA.
authors.forename: D
authors.initials: D
authors.lastname: Rothman
authors.forename: H
authors.initials: H
authors.lastname: Allen
authors.forename: L
authors.initials: L
authors.lastname: Herzog
authors.forename: A
authors.initials: A
authors.lastname: Pilapil
authors.forename: C M
authors.initials: CM
authors.lastname: Seiler
authors.forename: R B
authors.initials: RB
authors.lastname: Zurier
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000494:pharmacology; D016718:Arachidonic Acid / Q000494:pharmacology*; D002470:Cell Survival; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007700:Kinetics; D007948:Leukemia, Monocytic, Acute; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D019308:Palmitic Acid / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D007375:Interleukin-1; D008070:Lipopolysaccharides; D016718:Arachidonic Acid; D019308:Palmitic Acid; D015118:Eicosapentaenoic Acid; D015126:8,11,14-Eicosatrienoic Acid