title: Neurologic outcome of early versus late surgery for cervical spinal cord injury.
abstract: METHODS
  A prospective analysis evaluating neurologic outcome after early versus late surgery for cervical spinal cord trauma.
  
  
  OBJECTIVE
  The study was conducted to determine whether neurologic and functional outcome is improved in traumatic cervical spinal cord-injured patients (C3-T1, American Spinal Injury Association grades A-D) who had early surgery (<72 hours after spinal cord injury) compared with those patients who had late surgery (>5 days after spinal cord injury).
  
  
  BACKGROUND
  There is considerable controversy as to the appropriate timing of surgical decompression and stabilization for cervical spinal cord trauma. There have been numerous retrospective studies, but no prospective studies, to determine whether neurologic outcome is best after early versus late surgical treatment for cervical spinal cord injury.
  
  
  METHODS
  Patients meeting appropriate inclusion criteria were randomized to an early (<72 hours after spinal cord injury) or late (>5 days after spinal cord injury) surgical treatment protocol. The neurologic and functional outcomes were recorded from the acute hospital admission to the most recent follow-up.
  
  
  RESULTS
  Comparison of the two groups showed no significant difference in length of acute postoperative intensive care stay, length of inpatient rehabilitation, or improvement in American Spinal Injury Association grade or motor score between early (mean, 1.8 days) versus late (mean, 16.8 days) surgery.
  
  
  CONCLUSIONS
  The results of this study reveal no significant neurologic benefit when cervical spinal cord decompression after trauma is performed less than 72 hours after injury (mean, 1.8 days) as opposed to waiting longer than 5 days (mean, 16.8 days).
authors.affiliation: Department of Orthopaedic Surgery, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Vaccaro
authors.forename: R J
authors.initials: RJ
authors.lastname: Daugherty
authors.forename: T P
authors.initials: TP
authors.lastname: Sheehan
authors.forename: S J
authors.initials: SJ
authors.lastname: Dante
authors.forename: J M
authors.initials: JM
authors.lastname: Cotler
authors.forename: R A
authors.initials: RA
authors.lastname: Balderston
authors.forename: G J
authors.initials: GJ
authors.lastname: Herbison
authors.forename: B E
authors.initials: BE
authors.lastname: Northrup
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002574:Cervical Vertebrae / Q000293:injuries*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011446:Prospective Studies; D013119:Spinal Cord Injuries / Q000401:mortality / Q000534:rehabilitation / Q000601:surgery*; D013997:Time Factors