Nonalcoholic steatohepatitis masquerading as autoimmune hepatitis.
Nonalcoholic steatohepatitis is an increasingly recognized clinicopathologic condition. We report two cases of nonalcoholic steatohepatitis in middle-aged Japanese women whose clinical and laboratory data mimicked autoimmune hepatitis. Histologic findings of both cases were definite steatohepatitis with portal and pericellular fibrosis. Both patients' HLA-DR haplotypes were DR4 and DR2, which are frequently observed in Japanese patients with autoimmune hepatitis. Our cases suggest a diversity in the pathogenesis of nonalcoholic steatohepatitis.
Tajiri
K
K
Second Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Takenawa
H
H
Yamaoka
K
K
Yamane
M
M
Marumo
F
F
Sato
C
C
D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000473:pathology*; D005260:Female; D006505:Hepatitis / Q000473:pathology*; D019693:Hepatitis, Autoimmune / Q000473:pathology*; D006801:Humans; D008875:Middle Aged