title: Decreased cerebrospinal fluid levels of substance P in patients with Rett syndrome.
abstract: To clarify the mechanism of brain and spinal cord impairment in Rett syndrome (RS), we measured the cerebrospinal fluid (CSF) levels of substance P in 20 patients with RS including 16 childhood patients and 4 adult patients. Findings were compared with those obtained in age-matched controls and diseased controls. The CSF level of substance P was significantly lower in patients with RS compared with controls. The alteration in the CSF level of substance P may be related to the neurological impairment, especially autonomic dysfunction, and neuropathological involvement of dorsal root ganglia and peripheral nerve observed in RS.
authors.affiliation: Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume City, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsuishi
authors.forename: S
authors.initials: S
authors.lastname: Nagamitsu
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Murakami
authors.forename: A
authors.initials: A
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Shoji
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: A K
authors.initials: AK
authors.lastname: Percy
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D015518:Rett Syndrome / Q000134:cerebrospinal fluid* / Q000150:complications; D013373:Substance P / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D013373:Substance P