title: Arabidopsis NPH1: a protein kinase with a putative redox-sensing domain.
abstract: The NPH1 (nonphototropic hypocotyl 1) gene encodes an essential component acting very early in the signal-transduction chain for phototropism. Arabidopsis NPH1 contains a serine-threonine kinase domain and LOV1 and LOV2 repeats that share similarity (36 to 56 percent) with Halobacterium salinarium Bat, Azotobacter vinelandii NIFL, Neurospora crassa White Collar-1, Escherichia coli Aer, and the Eag family of potassium-channel proteins from Drosophila and mammals. Sequence similarity with a known (NIFL) and a suspected (Aer) flavoprotein suggests that NPH1 LOV1 and LOV2 may be flavin-binding domains that regulate kinase activity in response to blue light-induced redox changes.
authors.affiliation: Department of Plant Biology, Carnegie Institution of Washington, 260 Panama Street, Stanford, CA 94305, USA.
authors.forename: E
authors.initials: E
authors.lastname: Huala
authors.forename: P W
authors.initials: PW
authors.lastname: Oeller
authors.forename: E
authors.initials: E
authors.lastname: Liscum
authors.forename: I S
authors.initials: IS
authors.lastname: Han
authors.forename: E
authors.initials: E
authors.lastname: Larsen
authors.forename: W R
authors.initials: WR
authors.lastname: Briggs
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017360:Arabidopsis / Q000201:enzymology* / Q000502:physiology; D029681:Arabidopsis Proteins; D001426:Bacterial Proteins / Q000737:chemistry; D003001:Cloning, Molecular; D004594:Electrophysiology; D006801:Humans; D008027:Light; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D010750:Phosphoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D018524:Phototropism; D015221:Potassium Channels / Q000737:chemistry; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D001426:Bacterial Proteins; D010750:Phosphoproteins; D015221:Potassium Channels; C084296:nifL protein, Bacteria; C103646:NPH1 protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases