title: [The structural-functional organization of the diphtheria toxin].
abstract: The present data on the structure and functional features of diphtheria toxin, the main pathogenic factor of diphtheria infection, have been described. Information on the primary and secondary structures and X-ray analysis of this protein is presented and discussed. The structures of catalytic, transmembrane and receptor-binding domains of diphtheria toxin have been considered in detail and the functional roles of some amino-acid residues of these domains have been analyzed.
authors.forename: Ia F
authors.initials: IaF
authors.lastname: Zhukova
authors.forename: H H
authors.initials: HH
authors.lastname: Dzhedzhula
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Radavs'kyĭ
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004167:Diphtheria Toxin / Q000032:analysis / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D017433:Protein Structure, Secondary; D013329:Structure-Activity Relationship
chemical_list: D004167:Diphtheria Toxin