title: ATP synthase: an electrochemical transducer with rotatory mechanics.
abstract: ATP synthase (F0F1-ATPase) uses proton- or sodium-motive force to produce ATP form ADP and P(i). Three lines of experiment have recently demonstrated large-scale intersubunit rotation during ATP hydrolysis by F1. We discuss how ion flow through the membrane-intrinsic portion, F0, may generate torque and how this might be transmitted between stator and rotor to finally expel spontaneously formed ATP from F1 into water.
authors.affiliation: Universität Osnabrück, Abt. Biophysik, Germany. junge@uni-osnabrueck.de
authors.forename: W
authors.initials: W
authors.lastname: Junge
authors.forename: H
authors.initials: H
authors.lastname: Lill
authors.forename: S
authors.initials: S
authors.lastname: Engelbrecht
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D006801:Humans; D006868:Hydrolysis; D006180:Proton-Translocating ATPases / Q000737:chemistry / Q000378:metabolism; D011522:Protons; D014867:Water / Q000737:chemistry
chemical_list: D011522:Protons; D014867:Water; D000255:Adenosine Triphosphate; D006180:Proton-Translocating ATPases