ATP synthase: an electrochemical transducer with rotatory mechanics.
ATP synthase (F0F1-ATPase) uses proton- or sodium-motive force to produce ATP form ADP and P(i). Three lines of experiment have recently demonstrated large-scale intersubunit rotation during ATP hydrolysis by F1. We discuss how ion flow through the membrane-intrinsic portion, F0, may generate torque and how this might be transmitted between stator and rotor to finally expel spontaneously formed ATP from F1 into water.
Junge
W
W
Universität Osnabrück, Abt. Biophysik, Germany. junge@uni-osnabrueck.de
Lill
H
H
Engelbrecht
S
S
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D006801:Humans; D006868:Hydrolysis; D006180:Proton-Translocating ATPases / Q000737:chemistry / Q000378:metabolism; D011522:Protons; D014867:Water / Q000737:chemistry
D011522:Protons; D014867:Water; D000255:Adenosine Triphosphate; D006180:Proton-Translocating ATPases