Reversible paralysis with status asthmaticus, steroids, and pancuronium: clinical electrophysiological correlates.
Prolonged neuromuscular weakness has been identified after neuromuscular blockade in intensive care unit patients on mechanical ventilation. Previously reported electromyographic studies in these patients documented both neurogenic features and features consistent with a myopathy. We recorded sequential electrophysiological parameters during recovery from neuromuscular blockade in 5 patients with clinical weakness. An evolving pattern was identified. The early features were in keeping with previous reports of neurogenic changes, and this evolved into features consistent with a primary myopathy. Several potential underlying mechanisms are discussed.
Road
J
J
Department of Medicine-Respiratory Division and Neurology Division, Vancouver Hospital & Health Sciences Centre, The University of British Columbia, Canada.
Mackie
G
G
Jiang
T X
TX
Stewart
H
H
Eisen
A
A
D000328:Adult; D004576:Electromyography; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects / Q000503:physiopathology; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects* / Q000627:therapeutic use; D010197:Pancuronium / Q000627:therapeutic use*; D013224:Status Asthmaticus / Q000503:physiopathology* / Q000628:therapy*
D005938:Glucocorticoids; D009466:Neuromuscular Blocking Agents; D010197:Pancuronium; D008775:Methylprednisolone