title: Risk factors for salivary dysfunction in children 1 year after bone marrow transplantation.
abstract: Bone marrow transplantation (BMT) in childhood has improved the survival for children with leukaemia, severe aplastic anaemia and some metabolic disorders. However, transplant procedures are associated with a high incidence of deleterious long-term complications. This study included 49 children, conditioned according to the Seattle protocols. Follow-up oral examinations were performed 1 year after BMT. Forty risk factors that may have influenced a low stimulated salivary secretion rate (SSSR) were studied. An SSSR < or = 0.5 ml/min, 1 year after BMT was regarded as the event. One year after BMT, the mean SSSR was 0.5 +/- 0.4 ml/min in children conditioned with total body irradiation (TBI) compared to 1.0 +/- 0.5 ml/min in non-irradiated children (P = 0.0013). Significant predictors for low SSSR in multivariate analysis were: conditioning with TBI (P = 0.0023), recipient female sex (P = 0.0121) and recipient seropositivity for between three and four herpes viruses (P = 0.0157).
authors.affiliation: Department of Paediatric Dentistry, Karolinska Institutet, Huddinge, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Dahllöf
authors.forename: M
authors.initials: M
authors.lastname: Bågesund
authors.forename: M
authors.initials: M
authors.lastname: Remberger
authors.forename: O
authors.initials: O
authors.lastname: Ringdén
mesh_terms: D000704:Analysis of Variance; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006566:Herpesviridae Infections / Q000150:complications; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors; D012463:Saliva / Q000378:metabolism; D012466:Salivary Gland Diseases / Q000209:etiology*; D012737:Sex Factors; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014916:Whole-Body Irradiation / Q000009:adverse effects