title: CCK biosynthesis and processing: recent progress and future challenges.
abstract: The peptide cholecystokinin (CCK), like other peptides which pass through the regulated secretory pathway, undergoes a number of post-translational modifications during its biosynthesis including tyrosine sulfation, endoproteolytic cleavage, and trimming by carboxypeptidases. This minireview summarizes what is known about this process in endocrine cells and in the Cpe(fat)/Cpe(fat) mouse and points out what challenges remain for future research.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Beinfeld
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000096:biosynthesis* / Q000378:metabolism; D006801:Humans; D051379:Mice; D009928:Organ Specificity; D011498:Protein Precursors / Q000378:metabolism
chemical_list: D011498:Protein Precursors; C060249:procholecystokinin; D002766:Cholecystokinin