title: Psychosocial factors and coronary disease. A national multicenter clinical trial (ENRICHD) with a North Carolina focus.
abstract: In addition to traditional risk factors (cigarette smoking, high blood pressure, and elevated cholesterol) psychosocial factors (depression, social isolation, and low socioeconomic status) have an adverse impact on prognosis of patients with CAD. Several studies of psychosocial and behavioral treatments provide encouraging evidence for the clinical efficacy of psychosocial interventions in CAD patients. A new, multicenter clinical trial now underway (see sidebar) will evaluate the impact of psychosocial interventions (compared to usual care) on all-cause mortality and nonfatal MI in post-MI patients with depression or perceived low levels of social support or both.
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Blumenthal
authors.forename: C
authors.initials: C
authors.lastname: O'Connor
authors.forename: A
authors.initials: A
authors.lastname: Hinderliter
authors.forename: K
authors.initials: K
authors.lastname: Fath
authors.forename: S B
authors.initials: SB
authors.lastname: Hegde
authors.forename: G
authors.initials: G
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Puma
authors.forename: W
authors.initials: W
authors.lastname: Sessions
authors.forename: D
authors.initials: D
authors.lastname: Sheps
authors.forename: B
authors.initials: B
authors.lastname: Zakhary
authors.forename: R B
authors.initials: RB
authors.lastname: Williams
mesh_terms: D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000523:psychology* / Q000628:therapy*; D003863:Depression / Q000150:complications / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D015337:Multicenter Studies as Topic; D011379:Prognosis; D012934:Social Isolation; D012959:Socioeconomic Factors