title: Pachydermoperiostosis in childhood.
abstract: We report a family with pachydermoperiostosis (idiopathic hypertrophic osteoarthropathy) spanning four generations with 10 affected individuals, four of whom are children although pachydermoperiostosis is rare in childhood. In this family, with intermarriage, the inheritance is autosomal recessive and it is possible that there are individuals who are homozygous for the pachydermoperiostosis gene. These individuals do not appear to be more severely affected, although one of them had a cleft palate and congenital heart defect which may be a manifestation of being homozygous.
authors.affiliation: St Luke's Hospital, Bradford.
authors.forename: G P
authors.initials: GP
authors.lastname: Sinha
authors.forename: P
authors.initials: P
authors.lastname: Curtis
authors.forename: D
authors.initials: D
authors.lastname: Haigh
authors.forename: G T
authors.initials: GT
authors.lastname: Lealman
authors.forename: W
authors.initials: W
authors.lastname: Dodds
authors.forename: C P
authors.initials: CP
authors.lastname: Bennett
mesh_terms: D001249:Asthma / Q000150:complications; D002648:Child; D002675:Child, Preschool; D002972:Cleft Palate / Q000150:complications; D003241:Consanguinity; D004374:Ductus Arteriosus, Patent / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D010004:Osteoarthropathy, Primary Hypertrophic / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D010375:Pedigree; D011859:Radiography