title: Genital plus audiovisual sexual stimulation following intracavernous vasoactive injection versus re-dosing for erectile dysfunction--results of a prospective study.
abstract: OBJECTIVE
  We assessed whether re-dosing of a vasoactive agent or the combination of a vasoactive injection and genital plus audiovisual sexual stimulation caused the greatest erectile effect to determine which of the 2 procedures would be better for dynamic penile color Doppler sonography in patients with erectile dysfunction.
  
  
  METHODS
  A total of 20 consecutive patients with erectile dysfunction underwent 2 sessions under real-time RigiScan* recording of penile erection. Session 1 consisted of adaptation in 10 minutes, intracavernous injection of 10 micrograms. alprostadil in 10 minutes and re-dosing of 10 micrograms. alprostadil in 10 minutes. Session 2 consisted of adaptation in 10 minutes, injection of 10 micrograms. alprostadil in 10 minutes and genital plus audiovisual sexual stimulation in 10 minutes. The total duration of each session was 30 minutes. The order of the 2 sessions was randomly assigned with a week interval between each session.
  
  
  RESULTS
  Re-dosing and genital plus audiovisual sexual stimulation caused a significant increase in erectile response compared to the result seen after the first injection (re-dosing p < 0.05, injection plus stimulation p < 0.01). However, erectile response after the genital stimulation session was significantly greater than that after re-dosing (p < 0.01). An erection comparable to the greatest spontaneous erection reported by the patient was much more frequently achieved after genital stimulation than after the re-dosing session (p < 0.01).
  
  
  CONCLUSIONS
  The combination of injection and stimulation caused a significantly greater erectile response than re-dosing. We suggest that the former should always be used during color Doppler sonography to optimize the accuracy of the test. Re-dosing is suggested when an incomplete erectile response occurs after the injection plus stimulation phase.
authors.affiliation: Department of Neurology, University of Milan School of Medicine, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Montorsi
authors.forename: G
authors.initials: G
authors.lastname: Guazzoni
authors.forename: L
authors.initials: L
authors.lastname: Barbieri
authors.forename: L
authors.initials: L
authors.lastname: Ferini-Strambi
authors.forename: S
authors.initials: S
authors.lastname: Iannaccone
authors.forename: G
authors.initials: G
authors.lastname: Calori
authors.forename: L
authors.initials: L
authors.lastname: Nava
authors.forename: P
authors.initials: P
authors.lastname: Rigatti
authors.forename: G
authors.initials: G
authors.lastname: Pizzini
authors.forename: A
authors.initials: A
authors.lastname: Miani
mesh_terms: D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage*; D001296:Audiovisual Aids; D018592:Cross-Over Studies; D007172:Erectile Dysfunction / Q000628:therapy*; D004882:Erotica; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000502:physiology*; D010775:Photic Stimulation; D010812:Physical Stimulation; D011446:Prospective Studies; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil