title: A simple, non-invasive method for the measurement of reserpine-induced tremor in rats.
abstract: A new, non-invasive method for measuring reserpine-induced tremor in rodents is described here. The test procedure is based on the piezo-electric principle and was evaluated using the tremorogenic compound reserpine and the stereotypies-inducing drug apomorphine. Whereas for reserpine an orderly and dose-related increase in activity was observed, no such effect was detected with apomorphine. In order to further evaluate the test procedure, studies on the antagonism of reserpine-induced tremor were also performed. Results from these studies indicated that the DA-agonist lisuride, but not the S2-antagonist ritanserin, were able to antagonize the reserpine-induced tremor in a dose-related manner.
authors.affiliation: Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium. Tmeert@janbe.jnj.com.
authors.forename: T F
authors.initials: TF
authors.lastname: Meert
authors.forename: J
authors.initials: J
authors.lastname: Rombouts
authors.forename: J
authors.initials: J
authors.lastname: Voeten
authors.forename: F
authors.initials: F
authors.lastname: Naranji
authors.forename: G
authors.initials: G
authors.lastname: Clincke
mesh_terms: D000818:Animals; D004553:Electric Conductivity; D004581:Electronics / Q000295:instrumentation*; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000494:pharmacology*; D013565:Sympatholytics / Q000494:pharmacology*; D014202:Tremor / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D013565:Sympatholytics; D012110:Reserpine