[Selenium, antioxidant status and radical/reactive oxygen species in medicine].
BACKGROUND
In all organisms with a metabolism of oxygen, radicals/reactive oxygen species appear. Normally a balance exists between formation and destruction of radicals. Many diseases show a disturbance of this balance with the destruction of biological structures. Results in patients with sepsis, terminal renal failure, bone marrow transplantation and cancer are given.


CONCLUSIONS
To avoid a possible pro-oxidative effect (vitamins C and E) and intoxications (selenium), before substitution a monitoring is necessary.
Winnefeld
K
K
Institut für Klinische Chemie, Friedrich-Schiller-Universität, Jena.
D000975:Antioxidants / Q000493:pharmacokinetics*; D016026:Bone Marrow Transplantation / Q000502:physiology; D005260:Female; D005609:Free Radicals; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012643:Selenium / Q000008:administration & dosage / Q000172:deficiency*; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species; D012643:Selenium