title: Acute hepatitis E by a new isolate acquired in the United States.
abstract: OBJECTIVE
  To report the first case of acute hepatitis E by a novel isolate acquired in the United States and confirmed by nucleotide sequencing.
  
  
  METHODS
  We describe the clinical manifestations and the results of associated laboratory studies in a man who was found to have acute hepatitis E infection.
  
  
  RESULTS
  A 62-year-old man was hospitalized because of fever, abdominal pain, and jaundice. After an initial evaluation did not provide a cause, his serum was found to be positive for IgG anti-hepatitis E virus (HEV) by three antibody assays. Serum was also positive for HEV RNA by reverse transcriptase polymerase chain reaction (PCR). Sequencing results from the PCR products demonstrated substantial differences at the nucleotide level between this strain and the known Mexican and Burmese strains.
  
  
  CONCLUSIONS
  On the basis of this initial report, HEV should be considered an etiologic agent in patients with acute non-ABC hepatitis in the United States.
authors.affiliation: Division of Gastroenterology and Internal Medicine, Mayo Clinic Rochester, Minnesota 55905, USA.
authors.forename: P Y
authors.initials: PY
authors.lastname: Kwo
authors.forename: G G
authors.initials: GG
authors.lastname: Schlauder
authors.forename: H A
authors.initials: HA
authors.lastname: Carpenter
authors.forename: P J
authors.initials: PJ
authors.lastname: Murphy
authors.forename: J E
authors.initials: JE
authors.lastname: Rosenblatt
authors.forename: G J
authors.initials: GJ
authors.lastname: Dawson
authors.forename: E E
authors.initials: EE
authors.lastname: Mast
authors.forename: K
authors.initials: K
authors.lastname: Krawczynski
authors.forename: V
authors.initials: V
authors.lastname: Balan
mesh_terms: D000208:Acute Disease; D003937:Diagnosis, Differential; D006508:Hepatitis Antibodies / Q000097:blood*; D016751:Hepatitis E / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D016752:Hepatitis E virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012367:RNA, Viral / Q000032:analysis; D012194:RNA-Directed DNA Polymerase
chemical_list: D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D012367:RNA, Viral; D012194:RNA-Directed DNA Polymerase