title: Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome.
abstract: Viral infections are thought to play a part in some cutaneous drug reactions. Human herpesvirus 6 (HHV6), which is the agent of exanthema subitum (sixth disease), has never been implicated in a drug reaction. We report a patient with severe phenobarbital-induced anticonvulsant hypersensitivity syndrome in whom a fulminant haemophagocytic syndrome was associated with HHV6 infection. We discuss the possible role of HHV6 in this reactive condition.
authors.affiliation: Service de dermatologie, Hôpital Bichat, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Descamps
authors.forename: F
authors.initials: F
authors.lastname: Bouscarat
authors.forename: S
authors.initials: S
authors.lastname: Laglenne
authors.forename: E
authors.initials: E
authors.lastname: Aslangul
authors.forename: B
authors.initials: B
authors.lastname: Veber
authors.forename: D
authors.initials: D
authors.lastname: Descamps
authors.forename: J L
authors.initials: JL
authors.lastname: Saraux
authors.forename: M J
authors.initials: MJ
authors.lastname: Grange
authors.forename: M
authors.initials: M
authors.lastname: Grossin
authors.forename: E
authors.initials: E
authors.lastname: Navratil
authors.forename: B
authors.initials: B
authors.lastname: Crickx
authors.forename: S
authors.initials: S
authors.lastname: Belaich
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000821:virology*; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D015654:Herpesvirus 6, Human; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology / Q000821:virology*; D006801:Humans; D010634:Phenobarbital / Q000009:adverse effects*; D013577:Syndrome
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital