New insights into atherosclerosis from studies with mouse models.
Atherosclerosis is a disease of the large arteries that is the cause of heart disease and stroke. It is a highly complex disorder with multiple genetic and environmental influences. The mouse model has proved very useful for studying atherosclerosis because genetic analysis and planned genetic modification are feasible in this organism. In this brief review, some recent findings are summarized and future prospects using mouse models to study atherosclerosis-related traits are discussed.
Shih
D M
DM
Department of Medicine, University of California, Los Angeles 90095, USA.
Welch
C
C
Lusis
A J
AJ
D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology*; D001692:Biological Transport; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000235:genetics; D004195:Disease Models, Animal; D015316:Genetic Therapy; D006801:Humans; D008074:Lipoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009765:Obesity / Q000150:complications / Q000235:genetics; D010084:Oxidation-Reduction; D014815:Vitamins / Q000378:metabolism
D008074:Lipoproteins; D014815:Vitamins