Effects of concanavalin A on cytokine mRNA expression in mouse liver.
The effects of concanavalin A (Con A) on liver cytokine gene expression was studied in mice. The CD4 mRNA expression in normal liver suggests the presence of CD4+ T cells. The administration of Con A induced interleukin (IL)-1beta, IL-2 and IL-2 receptor mRNAs, which implies lymphocyte activation in the liver. Interferon-gamma and tumor necrosis factor-alpha mRNA expressions were increased gradually. The present results showed that Con A induced liver cytokine genes. This cytokine gene induction might have been the result of lymphocyte activation in the liver.
Okamoto
T
T
Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama, Japan.
Kobayashi
T
T
D000818:Animals; D015704:CD4 Antigens; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism; D003208:Concanavalin A / Q000494:pharmacology* / Q000633:toxicity; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism
D015704:CD4 Antigens; D016207:Cytokines; D012333:RNA, Messenger; D003208:Concanavalin A