title: Relationships between cathepsin-D, pS2 protein and hormonal receptors in breast cancer cytosols: inconsistency with their established prognostic significance.
abstract: In this study the unexpected findings from the analysis of 278 breast cancer tissue specimens are reported. A surprising strongly positive correlation between an unfavourable and a favourable prognosis with markers cathepsin D and pS2 respectively, was revealed by linear regression analysis (Pearson, Student-T-Test). In the relevant literature reviewed only one similar, although indirect, observation was found. On the other hand, a weak relationship between pS2 and ER has emerged using the same method, while the pS2/PgR association remained strong. The latter supports the hypothesis that pS2 positivity is associated with positive PgR and may be a marker of functioning ER, irrespective of ER status. These and other similar findings underline the need for a better understanding of the underlying molecular events as well as the necessity of an effective prognostic evaluation model for breast cancer.
authors.affiliation: 1st Medical Oncology Department, St Savvas Cancer Hospital, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Ardavanis
authors.forename: F
authors.initials: F
authors.lastname: Gerakini
authors.forename: A
authors.initials: A
authors.lastname: Amanatidou
authors.forename: A
authors.initials: A
authors.lastname: Scorilas
authors.forename: C
authors.initials: C
authors.lastname: Pateras
authors.forename: A
authors.initials: A
authors.lastname: Garoufali
authors.forename: G
authors.initials: G
authors.lastname: Pissakas
authors.forename: K
authors.initials: K
authors.lastname: Stravolemos
authors.forename: N
authors.initials: N
authors.lastname: Apostolikas
authors.forename: I
authors.initials: I
authors.lastname: Yiotis
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D002402:Cathepsin D / Q000378:metabolism*; D006801:Humans; D007158:Immunologic Techniques; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D011506:Proteins / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D012044:Regression Analysis; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
chemical_list: D014408:Biomarkers, Tumor; D011506:Proteins; D011960:Receptors, Estrogen; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins; D002402:Cathepsin D