title: Expression of cyclin E in human gastric adenomas and adenocarcinomas: correlation with proliferative activity and p53 status.
abstract: The expression of cyclin E in human gastric adenomas and adenocarcinomas was examined immunohistochemically to elucidate the role of cyclin E in stomach carcinogenesis. The expression of cyclin E was detected in 49% (90/182) of the adenomas and 59% (260/439) of the adenocarcinomas. The incidence of strongly positive cases (overexpression of cyclin E) was significantly higher in the adenocarcinomas (29%; 128/439) than in the adenomas (4%; 8/182) (p < 0.01). The incidence of the cyclin E expression showed a tendency to be higher in deeply invasive carcinomas and in the cases with lymph node metastasis, while the incidence did not differ among histological types. The expression of cyclin E was significantly correlated with the proliferative activity of the tumor cells measured by KI-67 antigen expression (p < 0.01). It was also correlated with the abnormal accumulation of p53 protein in the tumor cells (p < 0.01). These results suggest that overexpression of cyclin E and subsequent deregulation of the cell cycle may confer the development and progression of the gastric carcinomas.
authors.affiliation: First Department of Pathology, Hiroshima University School of Medicine, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Yasui
authors.forename: Y
authors.initials: Y
authors.lastname: Akama
authors.forename: H
authors.initials: H
authors.lastname: Kuniyasu
authors.forename: H
authors.initials: H
authors.lastname: Yokozaki
authors.forename: S
authors.initials: S
authors.lastname: Semba
authors.forename: F
authors.initials: F
authors.lastname: Shimamoto
authors.forename: E
authors.initials: E
authors.lastname: Tahara
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D019927:Cyclin E / Q000096:biosynthesis*; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D019927:Cyclin E; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53