Amantadine does not have antiviral activity against Borna disease virus.
We have investigated the antiviral activity of amantadine (AD) against Borna disease virus (BDV) in several culture cell systems. We present evidence that AD, in the range 5 to 10 microM, does not have antiviral activity against BDV. Treatment of BDV infected cells with AD for six days caused neither a reduction in the number of infected cells, nor a decrease in steady state levels of BDV RNA or proteins. Moreover, treatment of cells with AD prior infection did not affect BDV multiplication, whereas influenza A virus yield was less than 1% with respect to that obtained in untreated control cells.
Cubitt
B
B
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California, USA.
de la Torre
J C
JC
D000547:Amantadine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D000956:Antigens, Viral / Q000378:metabolism; D000998:Antiviral Agents / Q000494:pharmacology*; D001891:Borna disease virus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D004285:Dogs; D012367:RNA, Viral / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000378:metabolism
D000956:Antigens, Viral; D000998:Antiviral Agents; D012367:RNA, Viral; D014764:Viral Proteins; C077347:p40 protein, Borna disease virus; D000547:Amantadine