Effects of cocaine and quinpirole on perceptual and motor functions in baboons.
The effects of cocaine and quinpirole were studied in baboons to determine whether quinpirole, a relatively selective D2/D3 dopamine agonist, produced effects similar to those of cocaine on perceptual and motor processes. To measure perceptual and motor function, three baboons were trained to discriminate differences between a standard vowel and four other synthetic vowels: response accuracy as well as response latencies, or "reaction times", were measured following drug administrations. Cocaine reduced reaction times in two baboons, and did not affect reaction times in a third; on the other hand, quinpirole lengthened reaction times in a dose-dependent manner in all baboons. Cocaine and quinpirole also differed in the time course to produce the maximal reaction time effect following drug administration. Cocaine and quinpirole did not differ consistently in their perceptual effects, as indicated by similar changes in d', a signal-detection index of discriminability. These distinct profiles of effects for cocaine and quinpirole suggest differing neurochemical actions for these two drugs.
Hienz
R D
RD
Center for Hearing Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Zarcone
T J
TJ
Pyle
D A
DA
Brady
J V
JV
D000818:Animals; D001307:Auditory Perception / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010215:Papio; D010465:Perception / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects*; D019257:Quinpirole / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D014705:Verbal Behavior / Q000187:drug effects
D018491:Dopamine Agonists; D018765:Dopamine Uptake Inhibitors; D019257:Quinpirole; D003042:Cocaine