title: Auditory evoked potential index: a quantitative measure of changes in auditory evoked potentials during general anaesthesia.
abstract: We describe a novel index derived from the auditory evoked potential, the auditory evoked potential index, and we compare it with latencies and amplitudes related to clinical signs of consciousness and unconsciousness. Eleven patients, scheduled for total knee replacement under spinal anaesthesia, completed the study. The initial mean (SD) value of the auditory evoked potential index was 72.5 (11.2). During the first period of unconsciousness it decreased to 39.6 (6.9) and returned to 66.8 (12.5) when patients regained consciousness. Thereafter, similar values were obtained whenever patients lost and regained consciousness. Latencies and amplitudes changed in a similar fashion. From all parameters studied, Na latencies had the greatest overlap between successive awake and asleep states. The auditory evoked potential index and Nb latencies had no overlap. The consistent changes demonstrated suggest that the auditory evoked potential index could be used as a reliable indicator of potential awareness during propofol anaesthesia instead of latencies and amplitudes.
authors.affiliation: Department of Anaesthetics, Law Hospital NHS Trust, Lanarkshire, UK.
authors.forename: H
authors.initials: H
authors.lastname: Mantzaridis
authors.forename: G N
authors.initials: GN
authors.lastname: Kenny
mesh_terms: D000768:Anesthesia, General; D000775:Anesthesia, Spinal; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D019645:Arthroplasty, Replacement, Knee; D003243:Consciousness / Q000187:drug effects; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016343:Monitoring, Intraoperative / Q000379:methods*; D015742:Propofol / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol