Carcinogenesis. The fate of intestinal segments used in urinary reconstruction.
The actual mechanism for risk of developing cancer in intestinal segments used for urinary diversion remains uncertain. The clinical and laboratory experiences are reviewed in this article. The pathogenesis is multifaceted, involving initiators and promoters of carcinogenesis. Molecular genetic technology may provide the key to decoding the mechanisms involved.
Malone
M J
MJ
Department of Urology, Lahey Hitchcock Medical Center, Burlington, Massachusetts, USA.
Izes
J K
JK
Hurley
L J
LJ
D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D014547:Urinary Diversion / Q000009:adverse effects*