[Results of oocyte donation in women with different indications, ages and therapeutic strategies].
OBJECTIVE
Compare the effectiveness of oocyte donation for various indications, ages and treatments.


METHODS
Retrospective analysis of 319 transfers for 184 couples (243 with fresh embryos and 76 with frozen embryos). Transfers are divided into: -7 groups according to indication: premature ovarian failure (POF) with normal caryotype n = 122, surgical POF n = 26, postchemotherapy and postradiation therapy POF n = 23, genetic disease carrier n = 11, IVF failure n = 69, primary amenorrhea n = 58, POF with abnormal caryotype n = 10. -2 groups according to the recipient's age (Group I < or = 40 years, Group II > 40 years); -3 groups according to the dose and the mode of administration of the treatment. Oocytes were donated by volunteer donors of less than 38 years having at last one child.


RESULTS
According to the recipient's age 31.3% clinical pregnancies (CP) and 24.2% ongoing pregnancies (OP) for group I, versus 19.4% CP and 11.9% OP for group II. The results according to the indication were similar except for postchemotherapy and postradiation therapy POF for which the rate of CP as well as the rate of OP were particularly low. For the treatment groups there is a significant reduction of CP and OP as the treatment dose increases.


CONCLUSIONS
The recipient's age plays an important role for the development of pregnancy and this shows that apparently uterine ageing also plays an undeniable role for the decline of female fertility. Increasing doses of estradiol reduces the rate of CP and OP. Postchemotherapy and postradition therapy POF has much lower results than other indications.
Saranti
L
L
Service de Gynécologie-Obstétrique, Hôpital A. Béclère, Clamart.
Allali
F
F
Olivennes
F
F
Schwab
B
B
Rongieres-Bertrand
C
C
Frydman
R
R
D000328:Adult; D000568:Amenorrhea / Q000150:complications*; D005260:Female; D030342:Genetic Diseases, Inborn / Q000517:prevention & control*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000628:therapy*; D008423:Maternal Age; D018587:Oocyte Donation / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D016649:Primary Ovarian Insufficiency / Q000150:complications*; D012189:Retrospective Studies