title: Intra-mesenteric artery steroid administration relieved severe refractory gastro-intestinal graft-vs.-host disease in an allogeneic bone marrow transplantation patient.
abstract: We report a case of severe gastro-intestinal (G-I) graft-vs.-host disease (GVHD) successfully treated with intra-mesenteric artery steroid administration. A 29-year-old man with severe aplastic anemia (SAA) was submitted to HLA-identical unrelated allogeneic bone marrow transplantation (BMT) and was found to be suffering from grade IV G-I GVHD. Although cyclosporine, steroid pulse therapy, and FK506 proved ineffective, 30 mg of water-soluble prednisolone as administered into each the superior and inferior mesenteric artery with remarkable effects. This treatment was repeated two times, and the symptoms of G-I GVHD disappeared completely.
authors.affiliation: Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Sakamaki
authors.forename: Y
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: K
authors.initials: K
authors.lastname: Kuribayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Nagamachi
authors.forename: K
authors.initials: K
authors.lastname: Morii
authors.forename: H
authors.initials: H
authors.lastname: Honma
authors.forename: K
authors.initials: K
authors.lastname: Kogawa
authors.forename: J
authors.initials: J
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006801:Humans; D007269:Injections, Intra-Arterial; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008638:Mesenteric Arteries; D011239:Prednisolone / Q000008:administration & dosage*; D012867:Skin / Q000473:pathology; D014184:Transplantation, Homologous
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone