Effects of milk-borne colony stimulating factor-1 on circulating growth factor levels in the newborn infant.
Colony stimulating factor-1 (CSF-1) concentrations in colostrum were 20 to 25 times higher than in serum at birth and declined with lactation. No difference in concentrations of circulating CSF-1, however, were noted between breast-fed and formula-fed infants, suggesting that milk-borne CSF-1 may feed back negatively on endogenous growth factor levels, may act locally in the gastrointestinal tract, or may be locally degraded.
Flidel-Rimon
O
O
Department of Pediatrics, Albert Einstein College of Medicine-Montefiore Medical Center, Bronx, New York, USA.
Roth
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P
D000818:Animals; D005260:Female; D005526:Food, Formulated; D005865:Gestational Age; D006133:Growth Substances / Q000097:blood*; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008297:Male; D008895:Milk, Human / Q000737:chemistry*; D011863:Radioimmunoassay
D006133:Growth Substances; D016173:Macrophage Colony-Stimulating Factor