Relationships between cathepsin-D, pS2 protein and hormonal receptors in breast cancer cytosols: inconsistency with their established prognostic significance.
In this study the unexpected findings from the analysis of 278 breast cancer tissue specimens are reported. A surprising strongly positive correlation between an unfavourable and a favourable prognosis with markers cathepsin D and pS2 respectively, was revealed by linear regression analysis (Pearson, Student-T-Test). In the relevant literature reviewed only one similar, although indirect, observation was found. On the other hand, a weak relationship between pS2 and ER has emerged using the same method, while the pS2/PgR association remained strong. The latter supports the hypothesis that pS2 positivity is associated with positive PgR and may be a marker of functioning ER, irrespective of ER status. These and other similar findings underline the need for a better understanding of the underlying molecular events as well as the necessity of an effective prognostic evaluation model for breast cancer.
Ardavanis
A
A
1st Medical Oncology Department, St Savvas Cancer Hospital, Athens, Greece.
Gerakini
F
F
Amanatidou
A
A
Scorilas
A
A
Pateras
C
C
Garoufali
A
A
Pissakas
G
G
Stravolemos
K
K
Apostolikas
N
N
Yiotis
I
I
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D002402:Cathepsin D / Q000378:metabolism*; D006801:Humans; D007158:Immunologic Techniques; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D011506:Proteins / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D012044:Regression Analysis; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
D014408:Biomarkers, Tumor; D011506:Proteins; D011960:Receptors, Estrogen; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins; D002402:Cathepsin D