Osteoporosis after total gastrectomy. Results of a prospective, clinical study.
BACKGROUND
Osteopenia and enhanced risk of fractures have been reported after partial gastrectomy, but the significance of total gastrectomy is still unknown.


METHODS
Twenty-six patients were followed up for at least 3 years after total gastrectomy. The intake and S-levels of vitamin D, phosphate, magnesium, and calcium were prospectively studied, and a whole-body dual-energy X-ray absorptiometry scan was performed at a mean of 5 years after gastrectomy.


RESULTS
At this time point we found normal blood levels of vitamin D, calcium, and phosphate. Food intakes of phosphate, calcium, magnesium, and vitamin D reached the recommended daily allowances. Bone mineral density was similar to that of a control population, and increasing values were seen concomitant with an increase in body weight with the time after gastrectomy.


CONCLUSIONS
Calcium homeostasis and bone mineral densities seem not to be affected by total gastrectomy, at least when studied over a period of 5 years, an observation that hypothetically can be explained by weight recovery with time after the operation.
Liedman
B
B
Dept. of Surgery, Sahlgren's University Hospital, Göteborg, Sweden.
Bosaeus
I
I
Mellström
D
D
Lundell
L
L
D000273:Adipose Tissue / Q000502:physiology; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000378:metabolism; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology; D002118:Calcium / Q000097:blood / Q000652:urine; D002149:Energy Intake; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000009:adverse effects*; D006801:Humans; D007421:Intestine, Small / Q000382:microbiology; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000493:pharmacokinetics; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery*; D010710:Phosphates / Q000097:blood; D011183:Postoperative Complications / Q000503:physiopathology; D015995:Prevalence; D011446:Prospective Studies; D012044:Regression Analysis; D013548:Sweden / Q000453:epidemiology; D014807:Vitamin D / Q000097:blood; D015431:Weight Loss / Q000502:physiology
D008903:Minerals; D010710:Phosphates; D014807:Vitamin D; D000469:Alkaline Phosphatase; D008274:Magnesium; D002118:Calcium