Fixed drug eruption from amoxycillin.
We present a case of fixed drug eruption on the genital mucosa induced by amoxycillin. Topical provocation was carried out, applying amoxycilin (10% pet) on the glans penis. No reaction was observed. Oral challenge with amoxycillin was followed by pruritic erythema on the glans penis 6 hours after the intake of 125 mg. The study of cross-reactivity to other betalactams showed good tolerance of phenoxymethyl-penicillin, which shares an identical nuclear structure with amoxycillin. The patient also tolerated cephadroxil, a cephalosporin with a side chain identical to that of amoxycillin. On reviewing the literature we have only found three reports of fixed drug eruption fue to amoxycillin.
Jiménez
I
I
Allergy Section, Marqués de Valdecilla Hospital, Santander, Spain.
Antón
E
E
Picáns
I
I
Sánchez
I
I
Quiñones
M D
MD
Jerez
J
J
D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D008297:Male; D010406:Penicillins / Q000009:adverse effects*; D010409:Penile Diseases / Q000139:chemically induced*; D012882:Skin Tests
D010406:Penicillins; D000658:Amoxicillin