Allergy to phosphorus sesquisulfide: 0.5% pet. is a more appropriate concentration for patch testing.
Patch testing was performed with phosphorus sesquisulfide P4S3 in 2 groups containing equal numbers of patients using different concentrations (0.5% P4S3 in pet. and 1% P4S3 in pet., the usual suggested test concentration as recommended by the International Contact Dermatitis Research Group). We found that there was a statistically significant increase in the number of clinically irrelevant irritant reactions in the group tested with the concentration (chi 2 = 16, p < 0.0004). We recommend that patch testing with phosphorous sesquisulfide should be at a reduced concentration of 0.5% pet.
Abdullah
A
A
Birmingham Skin Centre, City Hospital NHS Trust, UK.
Bourke
J F
JF
Foulds
I S
IS
D000485:Allergens / Q000008:administration & dosage* / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests / Q000379:methods* / Q000706:statistics & numerical data; D017553:Phosphorus Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D015995:Prevalence; D012680:Sensitivity and Specificity; D006113:United Kingdom
D000485:Allergens; D017553:Phosphorus Compounds; C033768:phosphorus sesquisulfide