A new antiherpetic agent, AH-1763 IIa, produced by Streptomyces cyaneus strain no. 1763.
A new antiherpetic agent, AH-1763 IIa, was isolated from the culture broth of strain No. 1763 identified as Streptomyces cyaneus. It was purified through column chromatographies of Diaion HP-10 and silica gel. The structure was determined to be 11-hydroxy-5-methyl-2-(2-hydroxy-1-methylpropyl)-4H-anthraceno [1,2-b]pyran-4,7,12-trione by several spectroscopic experiments, that is a new antibiotic belonging to pluramycin-group.
Uyeda
M
M
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Yokomizo
K
K
Ito
A
A
Nakayama
K
K
Watanabe
H
H
Kido
Y
Y
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D005285:Fermentation; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D014709:Vero Cells
C109704:AH 1763 IIa; D000880:Anthraquinones; D000998:Antiviral Agents; D011753:Pyrones