Genotoxicity of hydrazino-phtalazine antihypertensive drugs assessed by an in vitro micronucleus assay.
The genotoxicity of antihypertensive drugs, hydralazine, dihydralazine and binazine was assessed on the base of their capacity to induce micronuclei in L929 cell line. In our previous investigations we indicated that these drugs did not induce micronuclei in bone marrow polichromatic erythrocytes in PZH SFISS mice. Present results show that hydralazine and dihydralizine can induce micronuclei in vitro and that this effect depends on time of exposure and the concentration of drug.
Chłopkiewicz
B
B
Drug Institute, Warsaw, Poland.
D000818:Animals; D000959:Antihypertensive Agents / Q000633:toxicity*; D002460:Cell Line / Q000187:drug effects; D004078:Dihydralazine / Q000633:toxicity*; D006830:Hydralazine / Q000633:toxicity*; D051379:Mice; D015162:Micronucleus Tests; D014032:Todralazine / Q000633:toxicity*
D000959:Antihypertensive Agents; D006830:Hydralazine; D004078:Dihydralazine; D014032:Todralazine