title: Results with collagen fleece coated with fibrin glue (TachoComb). A macroscopical and histological experimental study.
abstract: Diffuse bleeding from parenchymatous organs at conventional surgery is eliminated with the usual methods coagulation tamponade or styches. We performed experimental series at 9 dogs. After resection of spleen, liver, pancreas and kidney, the bleeding surface was covered by collagen fleece coated with fibrin glue (TachoComb). Postoperatively 7 days, 10 days, 14 days and 28 days we made a relaparotomy. Then the results were analyzed macroscopically and microscopically. In the abdominal cavity neither significant quantity of blood nor greater adhesions were detected. At all cases the fibrin glue was found on place were it was put before. Histologically a perfect wound healing experienced. The fibrin glue (TachoComb) using at diffuse parenchymatous organs' bleeding give a very good results when the wound area is at least 1 cm beyond the immediate wound margin and the fibrin glue is applied onto the wound and pressed on it for 4-5 minutes.
authors.affiliation: Department of General Surgery, Kenézy Teaching Hospital, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Martis
authors.forename: I
authors.initials: I
authors.lastname: Mikó
authors.forename: T
authors.initials: T
authors.lastname: Szendröi
authors.forename: S
authors.initials: S
authors.lastname: Kathy
authors.forename: J
authors.initials: J
authors.lastname: Kovács
authors.forename: Z
authors.initials: Z
authors.lastname: Hajdu
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D004285:Dogs; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000627:therapeutic use; D005340:Fibrinogen / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006488:Hemostasis, Surgical / Q000379:methods*; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use; D006498:Hepatectomy; D007668:Kidney / Q000473:pathology; D007813:Laparotomy; D008099:Liver / Q000473:pathology; D009392:Nephrectomy; D010179:Pancreas / Q000473:pathology; D010180:Pancreatectomy; D012086:Reoperation; D013154:Spleen / Q000473:pathology; D013156:Splenectomy; D013536:Suture Techniques; D013917:Thrombin / Q000008:administration & dosage / Q000627:therapeutic use*; D000267:Tissue Adhesions / Q000473:pathology; D014014:Tissue Adhesives / Q000627:therapeutic use; D014945:Wound Healing
chemical_list: D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D014014:Tissue Adhesives; C093991:tachocomb; D005340:Fibrinogen; D007611:Aprotinin; D013917:Thrombin