[Radiation-protective effect of agonists of alpha-2 adrenergic receptors. Methyldopa].
MethylDOPA has the considerable (60-80%) and lasting RPE at both intraperitoneal (0.5-3.8 mmol/kg) and per os (3.8-7.1 mmol/kg) introduction in radiation dose 8 Gr (LD97/30). Optimal time for introduction is 0.5-3.0 hours intraperitoneally and 3-6 hours per os. Evidently, methylDOPA RPE is realized via alpha 2-adrenoceptors.
Kulinskiĭ
V I
VI
Kovtun
V Iu
VIu
Iashunskiĭ
V G
VG
Klimova
A L
AL
D000284:Administration, Oral; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D008750:Methyldopa / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D011837:Radiation-Protective Agents; D008750:Methyldopa