title: Fixed drug eruption from amoxycillin.
abstract: We present a case of fixed drug eruption on the genital mucosa induced by amoxycillin. Topical provocation was carried out, applying amoxycilin (10% pet) on the glans penis. No reaction was observed. Oral challenge with amoxycillin was followed by pruritic erythema on the glans penis 6 hours after the intake of 125 mg. The study of cross-reactivity to other betalactams showed good tolerance of phenoxymethyl-penicillin, which shares an identical nuclear structure with amoxycillin. The patient also tolerated cephadroxil, a cephalosporin with a side chain identical to that of amoxycillin. On reviewing the literature we have only found three reports of fixed drug eruption fue to amoxycillin.
authors.affiliation: Allergy Section, Marqués de Valdecilla Hospital, Santander, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Jiménez
authors.forename: E
authors.initials: E
authors.lastname: Antón
authors.forename: I
authors.initials: I
authors.lastname: Picáns
authors.forename: I
authors.initials: I
authors.lastname: Sánchez
authors.forename: M D
authors.initials: MD
authors.lastname: Quiñones
authors.forename: J
authors.initials: J
authors.lastname: Jerez
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D008297:Male; D010406:Penicillins / Q000009:adverse effects*; D010409:Penile Diseases / Q000139:chemically induced*; D012882:Skin Tests
chemical_list: D010406:Penicillins; D000658:Amoxicillin