The perfusion fraction in volunteers and in patients with ischaemic stroke.
The fractional volume of capillary blood, i.e. the perfusion fraction f, was measured with the aid of an echo-planar imaging protocol originally designed for the measurement of water diffusion. In healthy volunteers, reasonable f values were obtained. In patients with cerebral ischaemic stroke, a marked decrease in the f value was seen in the infarcted region as compared with corresponding values in the contralateral hemisphere. We suggest that perfusion-fraction measurements may add to the diagnostic value of water-mobility examinations in patients with ischaemic disease.
Wirestam
R
R
Department of Radiation Physics, Lund University Hospital, Sweden.
Brockstedt
S
S
Lindgren
A
A
Geijer
B
B
Thomsen
C
C
Holtås
S
S
Ståhlberg
F
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D002196:Capillaries / Q000033:anatomy & histology / Q000502:physiology; D002544:Cerebral Infarction / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D004058:Diffusion; D017352:Echo-Planar Imaging; D005500:Follow-Up Studies; D006801:Humans; D008833:Microcirculation; D008875:Middle Aged; D014867:Water
D014867:Water