title: [A case of Wegener's granulomatosis associated with refractory bowel granulomatous ulcers].
abstract: We describe a 58-year-old woman who developed Wegener's granulomatosis (WG) complicated by a perforation of the transverse colon caused by necrotizing granulomatous vasculitis. In addition, her colon lesion continued in spite of high dose corticosteroid and cyclophosphamide therapy. She was admitted to our hospital because of her severe tonsillitis in Dec., 1994. She was diagnosed as having WG because she had oral ulcer, antibiotics-resistant lung infiltration, renal dysfunction and positive C-ANCA. Just after we started high dose steroid therapy, the transverse colon was perforated because of vasculitis, and she underwent emergency operation. Many vasculitic lesions were found in the small intestine, colon, and mesenterium. The disease was improved by corticosteroid and cyclophosphamide therapy except for a sustained ulcer with necrotizing vasculitis in the sigmoid colon region even 1 year after the operation. Although WG rarely complicates digestive tract lesions as initial manifestations, they reach 12% of the causes of death of WG in Japan. Therefore, we should take care of digestive tract lesions when we follow-up patients with WG.
authors.affiliation: Department of Internal Medicine, Saga Medical School.
authors.forename: O
authors.initials: O
authors.lastname: Ushiyama
authors.forename: T
authors.initials: T
authors.lastname: Narikiyo
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Nagasawa
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003108:Colonic Diseases / Q000209:etiology* / Q000628:therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D013505:Digestive System Surgical Procedures; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000628:therapy; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology / Q000628:therapy; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D014456:Ulcer / Q000209:etiology* / Q000628:therapy
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D003520:Cyclophosphamide; D011239:Prednisolone