Food as a source of polycyclic aromatic carcinogens.
Polycyclic aromatic hydrocarbons (PAH) belong to a large chemical family comprising many different compounds with important biological activity in mutagenic and carcinogenic processes. PAH have been detected in both raw and processed foods. The presence of PAH in non-processed foods is associated with environmental pollution from both human and industrial activities, whereas contamination of processed foods can be caused by certain preservation and processing procedures. Both toxicological and epidemiological studies have shown a relation between such compounds and tumor development. The data indicate that PAH must undergo a biotransformation process that causes the formation of biologically active metabolites. In this process, the presence of an enzyme complex that is induced by different xenobiotics is implied, making the toxicity of such compounds hard to predict. As setting a threshold limit below which toxicity could be considered negligible is difficult, the presence of PAH in foodstuffs should be reduced to as low as possible by controlling environmental contamination and all procedures that could cause PAH contamination during food processing, preserving, and packaging.
Guillén
M D
MD
Faculty of Pharmacy, Basque Country University, Vitoria, Spain.
Sopelana
P
P
Partearroyo
M A
MA
D001711:Biotransformation; D002274:Carcinogens, Environmental / Q000009:adverse effects* / Q000493:pharmacokinetics; D005506:Food Contamination; D005511:Food Handling; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced*; D011083:Polycyclic Compounds / Q000009:adverse effects* / Q000493:pharmacokinetics
D002274:Carcinogens, Environmental; D011083:Polycyclic Compounds