Combined naloxone and fluoxetine on deprivation-induced binge eating of palatable foods in rats.
Opioid antagonism and serotonergic stimulation is associated with macronutrient-specific hypophagia in animals. In the present study we evaluated their systemic effect alone, and in combination, at various doses, on the intake of sweet carbohydrate-rich and sweet fat-rich foods, tastes, and nutrients that are typical of binge-food items. Low-dose (1 mg/kg) naloxone, alone, preferentially suppressed fat-rich intake while low-dose (2.5 mg/kg) fluoxetine, alone, preferentially suppressed carbohydrate-rich intake. Each drug at these doses, combined with various doses of the other (2.5-10 mg/kg fluoxetine; 0.01-1 mg/kg naloxone) additively suppressed both kinds of the sweet foods. Naloxone and fluoxetine have therapeutic potential in treating binge-eating disorders. This animal study suggests what shortcomings and benefits might be expected when combining these two agents.
Hagan
M M
MM
Department of Psychology, University of Texas at El Paso, 79968-0553, USA.
Holguin
F D
FD
Cabello
C E
CE
Hanscom
D R
DR
Moss
D E
DE
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D001067:Appetite Depressants / Q000494:pharmacology*; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D005473:Fluoxetine / Q000494:pharmacology*; D005508:Food Deprivation / Q000502:physiology; D005518:Food Preferences / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D018687:Antidepressive Agents, Second-Generation; D001067:Appetite Depressants; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D009292:Narcotic Antagonists; D005473:Fluoxetine; D009270:Naloxone