title: [Inhalation route for administration of systemic drugs].
abstract: With aerosolized administration of medicines, direct access to the lung is possible. Depending on the intrapulmonary behavior of each molecule, the aerosol mode of administration makes possible either a pulmonary topical action or a systemic action, thanks to the lung's wide vascular network. An inhaled molecule's pulmonary behavior is not predictable and must be studied on its own. Some medicines with a systemic aim have a topical effect after aerosol administration: furosemide, amiloride, morphine, interferons, cyclosporin and prostacyclin. Other medicines have systemic effects after aerosol administration: insulin, growth hormone, LHRH, calcitonin and nicotine. Heparin can be classified in either group depending on the dose and type of use.
authors.affiliation: Service de Pneumologie, CHU Bretonneau, Tours.
authors.forename: J P
authors.initials: JP
authors.lastname: Mallet
authors.forename: P
authors.initials: P
authors.lastname: Diot
authors.forename: E
authors.initials: E
authors.lastname: Lemarié
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000584:Amiloride / Q000008:administration & dosage; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage; D000959:Antihypertensive Agents / Q000008:administration & dosage; D000998:Antiviral Agents / Q000008:administration & dosage; D002116:Calcitonin / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D003524:Cyclosporins / Q000008:administration & dosage; D004232:Diuretics / Q000008:administration & dosage; D004285:Dogs; D011464:Epoprostenol / Q000008:administration & dosage; D005260:Female; D005665:Furosemide / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D013006:Growth Hormone / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D007372:Interferons / Q000008:administration & dosage; D008297:Male; D009020:Morphine / Q000008:administration & dosage; D009538:Nicotine / Q000008:administration & dosage; D018722:Nicotinic Agonists / Q000008:administration & dosage; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D051381:Rats
chemical_list: D000336:Aerosols; D000701:Analgesics, Opioid; D000925:Anticoagulants; D000959:Antihypertensive Agents; D000998:Antiviral Agents; D003524:Cyclosporins; D004232:Diuretics; D007004:Hypoglycemic Agents; D007166:Immunosuppressive Agents; D007328:Insulin; D018722:Nicotinic Agonists; D004364:Pharmaceutical Preparations; D007987:Gonadotropin-Releasing Hormone; D009538:Nicotine; D009020:Morphine; D000584:Amiloride; D005665:Furosemide; D013006:Growth Hormone; D006493:Heparin; D002116:Calcitonin; D007372:Interferons; D011464:Epoprostenol