title: Increased apoptosis of adult rat lymphocytes after single neonatal vitamin A treatment (hormonal imprinting). A flow cytometric analysis.
abstract: Newborn rats were treated with a single dose of vitamin A (retinol) and apoptosis of peripheral lymphocytes was studied by flow cytometry in adult age. Vitamin A treatment (hormonal imprinting) caused a moderate, however significant elevation in the number of apoptotic lymphocytes after three months. Dexamethasone or Concanavalin-A alone did not influence apoptosis significantly. However, in the neonatally retinol treated rats dexamathasone significantly elevated the quantity of apoptotic lymphocytes related to the control or Concanavalin-A treated control cells. The results call attention to the prolonged effect of hormonal imprinting in a new index and to the possible dangerous effects in human, neonatally treated with vitamin A.
authors.affiliation: Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Gaál
authors.forename: J
authors.initials: J
authors.lastname: Bocsi
authors.forename: A
authors.initials: A
authors.lastname: Falus
authors.forename: B
authors.initials: B
authors.lastname: Szende
authors.forename: G
authors.initials: G
authors.lastname: Csaba
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000187:drug effects*; D005260:Female; D005434:Flow Cytometry; D008214:Lymphocytes / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014801:Vitamin A / Q000494:pharmacology*
chemical_list: D014801:Vitamin A