Predictions of serum vancomycin concentrations by means of six different equations for calculation of creatinine clearance.
Serum vancomycin concentrations were predicted in 59 patients by means of the PKS programme using six different equations to calculate creatinine clearance. These equations are (i) Chiou & Hsu equation, (ii) Cockroft-Gault lean body-weight equation, (iii) Cockroft-Gault total body-weight equation, (iv) Jelliffe equation, (v) Jelliffe & Jelliffe equation, and (vi) Siersback-Neilsen equation. The predictions were made by using (i) the implemented population pharmacokinetic parameters (IPPP), and (ii) the Bayesian method (BM). The results show that (i) if IPPP can lead to under-predictions, and Chiou & Hsu equation is most suited for predictions, and (ii) if IPPP can lead to over-predictions, the Cockroft-Gault total body-weight equation is the most suited for predictions.
Wu
G
G
Institute of Clinical Pharmacology and Toxicology, University of Udine, Italy.
Furlanut
M
M
D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000097:blood* / Q000493:pharmacokinetics; D001835:Body Weight; D003404:Creatinine / Q000652:urine*; D006801:Humans; D008954:Models, Biological; D011237:Predictive Value of Tests; D014640:Vancomycin / Q000097:blood* / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D003404:Creatinine