title: S-100 immunoreactivity in melanomas of two marsupials, a bird, and a reptile.
abstract: S-100 proteins are abundant in melanocytes of the skin; thus, S-100 immunoreactivity has been used as a diagnostic criterion for melanoma in humans and other placental mammals. We tested cutaneous melanomas of two marsupials, a bird, and a snake for S-100 immunoreactivity, using a polyclonal rabbit antibovine S-100 antibody. The tumor from a Tasmanian Pademelon (Thylogale billaridierii) was composed of large epithelioid cells, most of which had S-100-positive cytoplasm. In general, there were only scattered individual spindle-shaped S-100-positive cells or groups of cells in the primary mass from a Spotted-tailed Quoll (Dasyurus maculatus); S-100 staining was primarily nuclear. Cells comprising the melanomas of the Australian Cormorant (Phalacrocorax carbo) and the Death Adder (Acanthophis antarcticus) were S-100-negative, although peripheral nerve bundles in both were S-100-positive.
authors.affiliation: Pathology Associates International, Jefferson, AR 72079, USA. dkusewitt@nctr.fda.gov
authors.forename: D F
authors.initials: DF
authors.lastname: Kusewitt
authors.forename: R L
authors.initials: RL
authors.lastname: Reece
authors.forename: K B
authors.initials: KB
authors.lastname: Miska
mesh_terms: D000818:Animals; D001715:Bird Diseases / Q000175:diagnosis / Q000473:pathology*; D001717:Birds; D005260:Female; D007106:Immune Sera / Q000032:analysis / Q000276:immunology; D007150:Immunohistochemistry / Q000379:methods; D008394:Marsupialia; D008544:Melanocytes / Q000737:chemistry / Q000473:pathology; D008545:Melanoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D011817:Rabbits; D012104:Reptiles; D009418:S100 Proteins / Q000032:analysis* / Q000276:immunology; D012867:Skin / Q000737:chemistry / Q000473:pathology; D012878:Skin Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*
chemical_list: D007106:Immune Sera; D009418:S100 Proteins