Allergic and immunologic skin disorders.
The skin represents a unique immunologic organ poised to protect the host from invading organisms and environmental antigens. The skin is also an important target for a variety of allergic and autoimmune responses. Mast cells are key to the pathogenesis of urticaria, angioedema, and mastocytosis. Atopic dermatitis is the consequence of an immunoregulatory abnormality resulting in a skin-directed T helper type 2 response. Allergic contact dermatitis is an example of classic delayed type hypersensitivity. Circulating autoantibodies against the epidermis are a key mechanism by which bullous skin diseases occur.
Leung
D Y
DY
Diaz
L A
LA
DeLeo
V
V
Soter
N A
NA
D000485:Allergens; D000799:Angioedema; D003872:Dermatitis; D006801:Humans; D006967:Hypersensitivity; D008415:Mastocytosis; D012871:Skin Diseases / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous; D014581:Urticaria
D000485:Allergens