Tyrosine kinase signaling at fertilization.
The unfertilized egg is a highly differentiated cell that retains unlimited developmental potential. The execution of that potential requires signal transduction pathways that release the egg from its quiescent metabolic state, direct the union of the maternal and paternal genome, and initiate a developmental program that will guide embryogenesis. The egg is equipped with an array of cytosolic as well as cell surface receptor protein tyrosine kinases as part of a preassembled signal transduction mechanism. These protein tyrosine kinases have been found to act at several points during this egg activation process, beginning as early as the initial sperm-egg interaction. While many of these kinase functions are common to all cells, several functions unique to fertilization demonstrate the versatility of this class of protein kinases.
Kinsey
W H
WH
University of Kansas Medical Center, Kansas City 66160, USA.
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005306:Fertilization / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010063:Ovum / Q000201:enzymology / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D013084:Sperm-Ovum Interactions; D015053:Zygote / Q000166:cytology / Q000378:metabolism / Q000502:physiology
D004791:Enzyme Inhibitors; D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases