Attenuation of salicylate-induced tinnitus by Ginkgo biloba extract in rats.
The effects of an extract from Ginkgo biloba, EGb 761, on tinnitus were tested using an animal model of tinnitus. Daily oral administration of EGb 761 in doses from 10 to 100 mg/ kg/day began 2 weeks before behavioral procedures and continued until the end of the experiment. Tinnitus was induced by daily administration of 321 mg/kg sodium salicylate s.c. (corresponding to 275 mg/kg/day of salicylate acid) in fourteen groups of pigmented rats, 6 animals/group. The results from salicylate- and EGb-761-treated animals were compared to control groups receiving either salicylate, saline, or EGb 761 only in doses of 100 mg/kg. Administration of EGb 761 resulted in a statistically significant decrease of the behavioral manifestation of tinnitus for doses of 25, 50 and 100 mg/kg/ day.
Jastreboff
P J
PJ
Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA. pjastreboff@surgery2.ab.umd.edu
Zhou
S
S
Jastreboff
M M
MM
Kwapisz
U
U
Gryczynska
U
U
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D020441:Ginkgo biloba; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D012459:Salicylates / Q000009:adverse effects*; D014012:Tinnitus / Q000139:chemically induced* / Q000188:drug therapy*; D000096983:Ginkgo Extract
D016166:Free Radical Scavengers; D010936:Plant Extracts; D012459:Salicylates; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract