Collagen for female genuine stress incontinence after a minimum 2-year follow-up.
OBJECTIVE
To evaluate the medium-term outcome of gluteraldehyde cross-linked (GAX) collagen in the treatment of genuine stress incontinence in women.


METHODS
The study comprised 111 women (age range 33-90 years) with genuine stress incontinence who were treated with para-urethral collagen injections between 1990 and 1995. The patients were followed prospectively and their clinical outcome documented. Pre- and post-operative urodynamic data were examined to determine any prognostic indicators.


RESULTS
The overall results at a minimum 2-year follow-up (mean 3.3) showed 25% of patients to be dry and a further 40% improved. Although there were significant changes in some urodynamic values, no predictive factors of success were identified. Previous surgery for stress incontinence did not influence the final outcome.


CONCLUSIONS
Para-urethral collagen injection is a safe and relatively simple procedure with acceptable results at the medium-term follow-up. It could be offered as a primary or secondary procedure to women with genuine stress incontinence who are unable or unwilling to undergo surgical treatment. Objective urodynamic assessment revealed no factors of prognostic significance.
Swami
S
S
Bristol Urological Institute, Southmead Hospital, UK.
Batista
J E
JE
Abrams
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000009:adverse effects; D003094:Collagen / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008875:Middle Aged; D011446:Prospective Studies; D017211:Treatment Failure; D014521:Urethra; D014546:Urinary Catheterization; D014550:Urinary Incontinence, Stress / Q000503:physiopathology / Q000628:therapy*; D016055:Urinary Retention / Q000209:etiology; D014563:Urodynamics
D001672:Biocompatible Materials; C048470:glutaraldehyde-cross-linked collagen; D003094:Collagen