A simple, non-invasive method for the measurement of reserpine-induced tremor in rats.
A new, non-invasive method for measuring reserpine-induced tremor in rodents is described here. The test procedure is based on the piezo-electric principle and was evaluated using the tremorogenic compound reserpine and the stereotypies-inducing drug apomorphine. Whereas for reserpine an orderly and dose-related increase in activity was observed, no such effect was detected with apomorphine. In order to further evaluate the test procedure, studies on the antagonism of reserpine-induced tremor were also performed. Results from these studies indicated that the DA-agonist lisuride, but not the S2-antagonist ritanserin, were able to antagonize the reserpine-induced tremor in a dose-related manner.
Meert
T F
TF
Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium. Tmeert@janbe.jnj.com.
Rombouts
J
J
Voeten
J
J
Naranji
F
F
Clincke
G
G
D000818:Animals; D004553:Electric Conductivity; D004581:Electronics / Q000295:instrumentation*; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000494:pharmacology*; D013565:Sympatholytics / Q000494:pharmacology*; D014202:Tremor / Q000139:chemically induced* / Q000175:diagnosis*
D013565:Sympatholytics; D012110:Reserpine