title: High-resolution ultrasound associated with aspiration biopsy in the follow-up of patients with differentiated thyroid cancer.
abstract: OBJECTIVE
  To assess the value of ultrasound in the follow-up of patients undergoing surgery for differentiated thyroid carcinoma.
  
  
  METHODS
  The study included 89 patients (70 women and 19 men) with differentiated thyroid carcinoma (76 papillary and 13 follicular cancer).
  
  
  METHODS
  High-frequency ultrasound (US) was used in the evaluation of 89 subjects who underwent surgery for thyroid carcinoma. Fine-needle aspiration was performed in cases with positive US. In addition, determinations of thyroglobulin (Tgb) in serum, scintigraphy with (131)I, and cervical palpation were evaluated. We determined sensitivity, specificity, and overall accuracy for each of these diagnostic methods.
  
  
  RESULTS
  Ultrasonography was positive in 22 subjects, 16 in the nodal area and 6 in the thyroid bed. Twenty-two subjects received fine-needle aspiration with US control; 13 (59%) of 22 were positive for cancer. The results of the US for detecting neoplastic disease showed a sensitivity of 65%, specificity of 86%, and overall accuracy of 82%. The overall accuracy for scintigraphy was 88% and for Tgb, 91%.
  
  
  CONCLUSIONS
  We concluded that US can be included in the follow-up protocol for patients undergoing surgery for differentiated cancer of thyroid, as a valuable tool to localize the recurrence. This technique is particularly useful in the evaluation of patients who are found to have elevated Tgb levels.
authors.affiliation: General Surgery Department, Hospital Universitario Virgen De La Arrixaca, Murcia, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Rodriguez
authors.forename: M
authors.initials: M
authors.lastname: Reus
authors.forename: A
authors.initials: A
authors.lastname: Moreno
authors.forename: M
authors.initials: M
authors.lastname: Martinez
authors.forename: T
authors.initials: T
authors.lastname: Soria
authors.forename: L
authors.initials: L
authors.lastname: Carrasco
authors.forename: P
authors.initials: P
authors.lastname: Parrilla
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010173:Palpation; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D007457:Iodine Radioisotopes; D013954:Thyroglobulin