title: Development of systemic lupus erythematosus in a rheumatoid arthritis patient with anti-ribosomal P protein antibody.
abstract: We describe a patient with rheumatoid arthritis (RA) whose sera contained a high titre of an antibody targeting cytoplasmic ribosomal P proteins (anti-P). This association preceded by 6 years the development of serological and clinical manifestations of systemic lupus erythematosus (SLE). The clinical significance of anti-P for the diagnosis of SLE is discussed.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hamasaki
authors.forename: T
authors.initials: T
authors.lastname: Mimura
authors.forename: H
authors.initials: H
authors.lastname: Kanda
authors.forename: N
authors.initials: N
authors.lastname: Morino
authors.forename: Y
authors.initials: Y
authors.lastname: Yazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Nojima
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000276:immunology; D015800:Protozoan Proteins; D012269:Ribosomal Proteins / Q000276:immunology*
chemical_list: D001323:Autoantibodies; C064601:L12E protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D012269:Ribosomal Proteins