Effect of low-dose radiation on mouse dermal tissue using wound strength as an endpoint.
OBJECTIVE
To investigate the existence of enhanced sensitivity of dermal tissue to low radiation doses in the range of 0.1 Gy to 4 Gy/fraction.


METHODS
Top-up technique of giving higher radiation doses to skin alone from 150 kVp X-rays followed by fractionated experimental doses to total body from 137Cs were given to C3H mice. Full-depth incisions were made and the tensile strength of skin from 14 day wounds were measured as a response of dermal tissue to radiation.


RESULTS
There was no evidence of enhanced radiosensitivity to doses as low as 0.1 Gy. The data were better fitted by a nonparametric method that predicted the shape of survival curve better than an induced-repair model.


CONCLUSIONS
Dermal tissue like spinal cord has a low sensitive fraction of cells, unlike jejunum, kidney or lung that showed sensitivity at these doses. Tissue kinetics play an important role in the use of low dose fractions to avoid injury to normal tissues.
Vegesna
V
V
Department of Radiation Oncology and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095-1714, USA.
McBride
W H
WH
Taylor
J M
JM
Withers
H R
HR
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D012867:Skin / Q000528:radiation effects*; D013718:Tensile Strength