Effect of experimental diabetes on the activities of hexokinase, glucose-6-phosphate dehydrogenase and catecholamines in rat erythrocytes of different ages.
Hexokinase and glucose-6-phosphate dehydrogenase were assayed in various circulating age fractions i.e., young, middle-aged and old red cell from control, diabetic and insulin-treated diabetic rats. An increase in the activity of hexokinase was observed in three age-wise separated fractions of red cells from diabetic animals in comparison to control. The activity of glucose-6-phosphate dehydrogenase on the other hand decreased in separated ageing fractions of diabetic red cells when compared to control. Reversal of these two enzymes were observed in insulin-treated diabetic rats. The levels of glycosylated haemoglobin and catecholamines were found to increase with ageing red cells in controls and also increased in red cells plasma.
Gupta
B L
BL
University Department of Zoology, L N Mithila University, Darbhanga, India.
Nehal
M
M
Baquer
N Z
NZ
D000818:Animals; D002395:Catecholamines / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000201:enzymology; D004905:Erythrocyte Aging / Q000502:physiology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006593:Hexokinase / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar
D002395:Catecholamines; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase