Treatment of fungal corneal ulcers with amphotericin B ointment.
OBJECTIVE
To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment.


METHODS
Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, respectively. By antifungal susceptibility testing, amphotericin B was shown to have the lowest minimal inhibitory concentration.


RESULTS
Topical administration of amphotericin B ointment resulted in dramatic improvement in fungal corneal ulcers.


CONCLUSIONS
Antifungal susceptibility tests may aid with selection of antifungal agents. Amphotericin B ointment is one of the promising therapies for keratomycosis caused by antimycotic-resistant fungi.
Hirose
H
H
Department of Ophthalmology, Nagoya University, School of Medicine, Japan. hirohiro@tsuru.med.nagoya-u.ac.jp
Terasaki
H
H
Awaya
S
S
Yasuma
T
T
D000287:Administration, Topical; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D003315:Cornea / Q000382:microbiology*; D065306:Corneal Injuries; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005129:Eye Foreign Bodies / Q000150:complications / Q000382:microbiology / Q000601:surgery; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005670:Fusarium / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D009824:Ointments
D000935:Antifungal Agents; D009824:Ointments; D000666:Amphotericin B