title: T1rho-relaxation in articular cartilage: effects of enzymatic degradation.
abstract: Spin-lattice relaxation in the rotating frame (T1rho) dispersion spectroscopy and imaging were used to study normal and enzymatically degraded bovine articular cartilage. Normal specimens demonstrate significant T1rho "dispersion" (approximately 60 to approximately 130 ms) in the 100 Hz to 9 kHz frequency range. Proteoglycan-degraded specimens have 33% greater T1rho values than collagen-degraded or normal samples. T1rho-weighted images reveal structure not found in conventional T1- or T2-weighted images. Our results suggest that T1rho measurements are selectively sensitive to proteoglycan content. The potential of this method in distinguishing the early degenerative changes in cartilage associated with osteoarthritis is discussed.
authors.affiliation: Department of Radiology, MMRRCC, University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: U
authors.initials: U
authors.lastname: Duvvuri
authors.forename: R
authors.initials: R
authors.lastname: Reddy
authors.forename: S D
authors.initials: SD
authors.lastname: Patel
authors.forename: J H
authors.initials: JH
authors.lastname: Kaufman
authors.forename: J B
authors.initials: JB
authors.lastname: Kneeland
authors.forename: J S
authors.initials: JS
authors.lastname: Leigh
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism*; D002417:Cattle; D010450:Endopeptidases / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D011509:Proteoglycans / Q000378:metabolism
chemical_list: D011509:Proteoglycans; D010450:Endopeptidases