[Acetaldehyde adducts in the cerebral cortex of ethanol-fed mice].
To investigate the neurotoxicity of acetaldehyde covalent adducts, immunohistochemical staining for acetaldehyde adducts using the antibody against acetaldehyde adducts, was performed in the cerebral cortex of ethanol-fed (withdrawal) mice. In the ethanol-fed mice, the degeneration in the cerebral cortex was found, while the protein epitope related to acetaldehyde was found in the cerebral cortex, liver and adrenal cortex. No histochemical and immunohistochemical changes in the tissues from the control mice were found. It is possible that acetaldehyde adducts may effect on the cerebral cortex as the neurotoxicity which cause psychosis such as delirium and hallucination after alcohol drinking.
Iwahashi
K
K
Department of Neuropsychiatry, Faculty of Medicine, Kagawa Medical University, Japan.
Itoh
M
M
Nakamura
K
K
Ameno
K
K
Suwaki
H
H
Takeuchi
Y
Y
D000079:Acetaldehyde / Q000378:metabolism* / Q000633:toxicity; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D000079:Acetaldehyde