title: Primary coexistent adenocarcinoma and choriocarcinoma of the stomach. A case report and review of the literature.
abstract: We report a case of primary gastric choriocarcinoma with liver metastasis. The mixed histologic patterns included adenocarcinoma, undifferentiated carcinoma, and choriocarcinoma. Immunohistologic staining for the beta-subunit of human chorionic gonadotrophin (beta-HCG) showed positive results in the choriocarcinoma, adenocarcinoma, and normal mucosal gland. However, positive HCG cells were present at different intensities in the choriocarcinoma, adenocarcinoma, and normal mucosal gland. The level of HCG was significantly increased in serum. This unusual tumor probably resulted from dedifferentiation of a primary adenocarcinoma or developed directly from the mucosal glands.
authors.affiliation: Department of Pathology, Taichung Veterans General Hospital, Taiwan, Republic of China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Jan
authors.forename: J T
authors.initials: JT
authors.lastname: Chen
authors.forename: W L
authors.initials: WL
authors.lastname: Ho
authors.forename: C C
authors.initials: CC
authors.lastname: Wu
authors.forename: D C
authors.initials: DC
authors.lastname: Yeh
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D000368:Aged; D002822:Choriocarcinoma / Q000737:chemistry / Q000473:pathology*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D018396:Mucin-1 / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology*; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D018396:Mucin-1; D000509:alpha-Fetoproteins; D007633:Keratins