Insulin resistance in patients with familial combined hyperlipidemia and coronary artery disease.
The minimum model modified by the administration of insulin provides an objective and relatively easily measured index of peripheral sensitivity to insulin which was significantly lower (p <0.02) in familial combined hyperlipidemia (FCH) with ischemic heart disease (IHD) than in FCH without IHD and in control subjects (1.2 +/- 0.6, 1.9 +/- 1.0, 2.9 +/- 1.2 x 10(-4) mU/L/ min, respectively). In patients with FCH, insulin resistance explains, at least in part, their metabolic alterations (hypertension, abnormal glucose tolerance, hyperinsulinemia) and elevated IHD.
Ascaso
J F
JF
Service of Endocrinology and Nutrition, Hospital Clinico, University of Valencia, Spain.
Lorente
R
R
Merchante
A
A
Real
J T
JT
Priego
A
A
Carmena
R
R
D001786:Blood Glucose / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D005951:Glucose Tolerance Test; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D012307:Risk Factors
D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins