title: Clinical trial of moxidectin oral gel in horses.
abstract: A clinical trial carried out over 98 days was done to evaluate treatment of horses with moxidectin gel for efficacy as measured by (1) reduction in the production of parasite ova post treatment, (2) a comparison of the posttreatment parasite egg count suppression of moxidectin to ivermectin, and (3) assessment of the field safety, animal acceptance of the moxidectin formulation, and the utility of the moxidectin delivery device. One hundred and fifty Standardbred horses with naturally acquired parasite infections were used in the study. Moxidectin had more prolonged and greater suppressive influence than did ivermectin on reappearance and magnitude of strongyle egg counts post treatment. Differences were not observed between the capability of ivermectin or moxidectin to reduce and suppress low Parascaris equorum egg counts. Adverse reactions to treatments were not observed, and the utility of the moxidectin delivery syringe and animal acceptance of moxidectin treatment were satisfactory.
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine, Gainesville, FL 32610-0125, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: DiPietro
authors.forename: D E
authors.initials: DE
authors.lastname: Hutchens
authors.forename: T F
authors.initials: TF
authors.lastname: Lock
authors.forename: K
authors.initials: K
authors.lastname: Walker
authors.forename: A J
authors.initials: AJ
authors.lastname: Paul
authors.forename: C
authors.initials: C
authors.lastname: Shipley
authors.forename: D
authors.initials: D
authors.lastname: Rulli
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents; D005782:Gels; D006734:Horse Diseases; D006736:Horses; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use; D010270:Parasite Egg Count / Q000662:veterinary; D017206:Strongylida Infections / Q000188:drug therapy / Q000662:veterinary*; D013323:Strongylus
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D005782:Gels; D018942:Macrolides; D007559:Ivermectin; C027837:moxidectin