title: Effects of oral glucose administration on plasma growth hormone levels in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the sensitivity of GH secretion to the suppressive effect of oral glucose administration in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Comparison of the GH response to an oral glucose load in women with PCOS and in weight-matched normally menstruating women (controls).
  
  
  METHODS
  Reproductive endocrinology unit.
  
  
  METHODS
  Eighteen obese and 11 nonobese patients and 10 obese and 10 nonobese controls.
  
  
  METHODS
  After an overnight fast, each woman underwent a 75-g, 3-hour oral glucose tolerance test (OGTT).
  
  
  METHODS
  Growth hormone, glucose, and insulin responses to OGTT.
  
  
  RESULTS
  No significant differences in the glycemic and insulinemic responses were found between the patients and the weight-matched controls. No decrease in plasma GH was observed in both obese and nonobese patients and in obese controls during the OGTT, whereas a significant GH decrease occurred in nonobese controls 60 and 120 minutes after glucose intake.
  
  
  CONCLUSIONS
  Oral glucose administration was unable to suppress GH levels in nonobese as well as in obese women with PCOS and in obese control women. These data suggest that both PCOS and obesity are associated with a reduced sensitivity of GH secretion to glucose suppression.
authors.affiliation: Department of Obstetrics and Gynecology, Università Cattolica S. Cuore, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Tropeano
authors.forename: A
authors.initials: A
authors.lastname: Barini
authors.forename: G
authors.initials: G
authors.lastname: Caroli
authors.forename: P
authors.initials: P
authors.lastname: Carfagna
authors.forename: I P
authors.initials: IP
authors.lastname: Vuolo
authors.forename: P
authors.initials: P
authors.lastname: Novelli
authors.forename: A
authors.initials: A
authors.lastname: Rossodivita
authors.forename: A
authors.initials: A
authors.lastname: Lucisano
authors.forename: A
authors.initials: A
authors.lastname: Lanzone
mesh_terms: D000284:Administration, Oral; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood* / Q000187:drug effects*; D006801:Humans; D009765:Obesity / Q000097:blood* / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D013006:Growth Hormone; D005947:Glucose