title: Anti-inflammatory action of methimazole.
abstract: The anti-inflammatory activity of 1-methylimidazole-2-thiol (methimazole), the most widely used antithyroid drug, was investigated. Methimazole had a marked inhibitory action on prostaglandin H synthase (IC50 = 10 mumol/l), inhibiting the peroxidase (IC50 = 330 mumol/l), although the cyclo-oxygenase was slightly activated. Methimazole was less potent than indometacin (IC50 = 1.7 mumol/l) on prostaglandin H synthase, but was more potent than acetylsalicylic acid (IC50 = 160 mumol/l). Methimazole has been found to trap superoxide (O2.-) radicals and to decrease the level of blood prostaglandin E2.
authors.affiliation: Department of Therapeutic and Organic Chemistry, Faculty of Pharmacy, Limoges, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Lagorce
authors.forename: T
authors.initials: T
authors.lastname: Moulard
authors.forename: A
authors.initials: A
authors.lastname: Rousseau
authors.forename: F
authors.initials: F
authors.lastname: Comby
authors.forename: J
authors.initials: J
authors.lastname: Buxeraud
authors.forename: C
authors.initials: C
authors.lastname: Raby
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008713:Methimazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D008713:Methimazole; D007213:Indomethacin