Infection of Anopheles freeborni mosquitoes on New World monkeys infected with the Uganda I/CDC strain of Plasmodium malariae.
Anopheles freeborni mosquitoes fed during 85 primary and 26 recrudescent infections of the Uganda I/CDC strain of Plasmodium malariae in Saimiri and Aotus monkeys were examined for the presence of oocysts. Of these, 42 primary and 14 recrudescent infections were infective. Mosquitoes were more frequently infected when fed upon A. lemurinus griseimembra animals. A retrospective examination indicated the greatest mosquito infectivity occurred before the maximum parasite count. Mosquito infection was highest 4, 5, and 6 days after the parasite count exceeded 1,000/microl. Overall, 98 of 304 positive lots (32.2%) had > or = 50% of the individual mosquitoes infected. In addition, lots of An. freeborni were fed through membranes on the blood of 34 monkeys. During the days following the parasite count reaching > or = 1,000/microl, feedings on the animals resulted in lower levels of infection than membrane feeding, thus extending the period of mosquito infection.
Collins
W E
WE
Division of Parasitic Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Chamblee, Georgia 30341, USA.
Richardson
B B
BB
Sullivan
J S
JS
Morris
C L
CL
Galland
G G
GG
D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D016645:Aotidae; D008288:Malaria / Q000097:blood / Q000469:parasitology* / Q000635:transmission*; D010270:Parasite Egg Count; D018512:Parasitemia / Q000469:parasitology; D010965:Plasmodium malariae / Q000254:growth & development* / Q000302:isolation & purification; D012008:Recurrence; D012189:Retrospective Studies; D012453:Saimiri; D014454:Uganda