Growth suppressing activity for endothelial cells induced from macrophages by carboxymethylated curdlan.
A carboxymethylated derivative of a linear (1-->3)-beta-D-glucan (CMCD) from Alcaligenes faecalis var. myxogenes acted directly on mouse peritoneal macrophages and mouse lymphoma P388D1 cells, and induced a growth suppressing activity for bovine artery endothelial cells (BAEs) from themselves at a concentration of 100 micrograms/ml. The suppressing activity was also detected in the mouse serum administered as an i.p. injection of CMCD at a dose of 100 mg/kg, suggesting that the growth suppressing activity was induced from macrophages potentiated by CMCD in vivo.
Usui
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S
Department of Hygienic Chemistry, Gifu Pharmaceutical University, Japan.
Matsunaga
T
T
Ukai
S
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Kiho
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002417:Cattle; D002450:Cell Communication / Q000187:drug effects* / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects*; D005936:Glucans / Q000494:pharmacology*; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology; D017737:Macrophages, Peritoneal / Q000166:cytology* / Q000187:drug effects*; D051379:Mice; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005936:Glucans