title: Review: JC virus infection of lymphocytes--revisited.
abstract: JC virus (JCV), the causative agent of the fatal human demyelinating disease progressive multifocal leukoencephalopathy (PML), is an opportunistic papovavirus that infects and destroys oligodendrocytes, the myelin-producing cells of the central nervous system. Since its isolation from the brain of a PML patient, JCV has long been classed as a neurotropic virus. Many studies, however, have demonstrated that JCV can infect various other cell types, including immune system cells. Moreover, several recent studies have focused specifically on lymphocytes as a target of JCV. This review chronicles the association of JCV with lymphocytes, including cell type localization, molecular regulation, and viral sequences, and discusses clinical implications of these findings.
authors.affiliation: Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, and Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19102, USA.
authors.forename: G L
authors.initials: GL
authors.lastname: Gallia
authors.forename: S A
authors.initials: SA
authors.lastname: Houff
authors.forename: E O
authors.initials: EO
authors.lastname: Major
authors.forename: K
authors.initials: K
authors.lastname: Khalili
mesh_terms: D000956:Antigens, Viral / Q000302:isolation & purification; D001773:Blood Cells / Q000821:virology; D001854:Bone Marrow Cells / Q000821:virology; D001921:Brain / Q000821:virology; D004279:DNA, Viral / Q000302:isolation & purification; D006801:Humans; D007577:JC Virus / Q000145:classification / Q000254:growth & development* / Q000472:pathogenicity; D008214:Lymphocytes / Q000821:virology*; D030361:Papillomavirus Infections / Q000821:virology*; D014412:Tumor Virus Infections / Q000821:virology*
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral