Psychosis following acute alteration of thyroid status.
OBJECTIVE
Mania with psychotic features presenting following abrupt normalisation of thyroid function from severe Graves's disease is reported.


METHODS
A 33-year-old man with severe, untreated Graves's disease was treated aggressively, with rapid restoration of normal serum thyroid hormone levels. Symptoms of mania and psychosis then developed.


METHODS
Time limited antipsychotic medication and continuing medical treatment.


RESULTS
There was resolution of psychiatric symptoms.


CONCLUSIONS
The association of mania and psychosis with thyroid disease is rare, but aggressive medical treatment and rapid restoration of normal serum thyroid levels may increase the risk of the emergence of such symptoms.
Irwin
R
R
Department of Psychological Medicine, Wellington School of Medicine, Wellington South, New Zealand.
Ellis
P M
PM
Delahunt
J
J
D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D006111:Graves Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D013960:Thyroid Function Tests
D013956:Antithyroid Agents; D006220:Haloperidol