title: [Occupational asthma caused by buckwheat flour].
abstract: Buckwheat flour, mainly used for pancakes, may induce asthma following inhalation and anaphylactic reactions following ingestion. These allergic reactions are mediated by specific IgE and may be confirmed by skin test and radio-allergo-sorbent test. The occupational asthma of a patient working in pancake restaurant was confirmed by specific challenge test with a computerised device to generate particles. A very small amount of buckwheat flour (10 micrograms) induced an immediate fall of the FEV1 to 56% of the initial value. No bronchial reaction was observed with lactose nor with wheat flour. Specific bronchial challenge identifies the allergen responsible for asthma, measures the level of sensitization and thus can prevent the occupational exposure.
authors.affiliation: Service de Pathologie Professionnelle, Hôpital Cochin, Paris.
authors.forename: D
authors.initials: D
authors.lastname: Choudat
authors.forename: C
authors.initials: C
authors.lastname: Villette
authors.forename: J F
authors.initials: JF
authors.lastname: Dessanges
authors.forename: M F
authors.initials: MF
authors.lastname: Combalot
authors.forename: J F
authors.initials: JF
authors.lastname: Fabries
authors.forename: A
authors.initials: A
authors.lastname: Lockhart
authors.forename: J
authors.initials: J
authors.lastname: Dall'Ava
authors.forename: F
authors.initials: F
authors.lastname: Conso
mesh_terms: D000328:Adult; D000485:Allergens; D001249:Asthma / Q000175:diagnosis / Q000209:etiology*; D001985:Bronchial Provocation Tests / Q000295:instrumentation; D019612:Fagopyrum / Q000009:adverse effects*; D005433:Flour / Q000009:adverse effects*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology*; D012147:Restaurants; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E