CT with different doses of the hepatocyte-specific contrast medium FP 736-03. Evaluation in a nude-rat model of experimental metastases.
OBJECTIVE
To study the dose-response relationship in FP 736-03 (48 mg I/ml), hepatocyte-specific contrast medium for CT of the liver.


METHODS
A nude-rat model of experimental hepatic metastases was used. CT of the liver was performed before and after i.v. injection of FP 736-03 at 4 different doses: 0.25, 0.5, 1.0 and 2.0 ml/kg b.w. Attenuation in the normal liver parenchyma and in the metastases was measured and plotted as a function of time.


RESULTS
The enhancement of the normal liver parenchyma increased in the dose range studied. No increase was found in the metastases: the attenuation here remained constant during the observation period. The maximum enhancement values at doses of 0.25, 0.5, 1.0 and 2.0 ml/kg b.w. were (mean +/- SD) 13.5 +/- 2.7, 30.1 +/- 4.2, 33.2 +/- 4.5 and 59.7 +/- 13.1 HU respectively.
Bergman
A
A
Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
Sundin
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Magnusson
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A
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary*; D000818:Animals; D002784:Cholesterol / Q000008:administration & dosage; D003287:Contrast Media / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004655:Emulsions; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage; D007275:Injections, Intravenous; D007459:Iodized Oil / Q000008:administration & dosage; D016014:Linear Models; D008099:Liver / Q000166:cytology / Q000000981:diagnostic imaging*; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000556:secondary*; D008297:Male; D009368:Neoplasm Transplantation; D010743:Phospholipids; D011856:Radiographic Image Enhancement; D051381:Rats; D011923:Rats, Nude; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods
D003287:Contrast Media; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; C092563:iodized oil, phospholipid, cholesterol emulsion; D007459:Iodized Oil; D002784:Cholesterol