title: Mouthwash use and dentures in relation to oral epithelial dysplasia.
abstract: This case-control study investigated the potential association between oral epithelial dysplasia (OED) and both mouthwash and denture use. Incident OED cases aged 20-79 years were identified through two oral pathology laboratories. Controls were pair-matched (1:1) to cases on age (+/- 5 years), gender, appointment date and surgeon. A telephone interview was used to obtain exposure information. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were generated using conditional logistic regression. Based upon 127 case-control pairs and after adjusting for smoking, drinking, education and either denture or mouthwash use, the OR for OED and regular mouthwash use (1+ uses/week for 6+ months) was 0.8 (95% CI, 0.4-1.5) while the OR for OED and wearing a denture was 0.7 (95% CI, 0.4-1.3). There were no clear trends of increased OED risk with increased mouthwash use or years of denture wearing. Our findings suggest that neither mouthwash nor denture use are associated positively with OED risk.
authors.affiliation: University of Connecticut Health Center School of Dental Medicine, Department of Behavioral Sciences and Community Health, Farmington 06030-3910, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Morse
authors.forename: R V
authors.initials: RV
authors.lastname: Katz
authors.forename: D G
authors.initials: DG
authors.lastname: Pendrys
authors.forename: T R
authors.initials: TR
authors.lastname: Holford
authors.forename: D J
authors.initials: DJ
authors.lastname: Krutchkoff
authors.forename: E
authors.initials: E
authors.lastname: Eisenberg
authors.forename: D L
authors.initials: DL
authors.lastname: Kosis
authors.forename: S
authors.initials: S
authors.lastname: Kerpel
authors.forename: P
authors.initials: P
authors.lastname: Freedman
authors.forename: S T
authors.initials: ST
authors.lastname: Mayne
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003778:Dentures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D009062:Mouth Neoplasms / Q000209:etiology*; D009067:Mouthwashes / Q000009:adverse effects*; D011230:Precancerous Conditions / Q000209:etiology*; D012307:Risk Factors
chemical_list: D009067:Mouthwashes