Studies on pyrazine derivatives. XXX. Synthesis of pyrazinylamino-1,3-diazacycloalkanes of potential circulatory activity.
A series of pyrazinylamino-1,3-diazacycloalkanes was obtained by reaction of the corresponding substituted aminopyrazines with aliphatic amines. Selected compounds were studied with respect to their potential circulatory activity. The effect on the blood pressure, isolated rat tail artery and heart atria, and an influence on the human blood platelet aggregation were investigated.
Foks
H
H
Department of Organic Chemistry, Medical University of Gdańsk.
Wisterowicz
K
K
Damasiewicz
B
B
Nasal
A
A
Petrusewicz
J
J
Radwańska
A
A
D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001158:Arteries / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000031:analogs & derivatives; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013623:Tail / Q000098:blood supply
D000588:Amines; D000959:Antihypertensive Agents; D010975:Platelet Aggregation Inhibitors; D011719:Pyrazines; D003000:Clonidine