Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)--a review.
The stomach provides some protection against the penetration of ethanol into the body by contributing to the metabolism of ethanol. The latter is attenuated by various drugs and, although the magnitude of this effect is still the subject of debate, patients should be warned of the corresponding possible increase in blood alcohol levels. Furthermore, oxidation of ethanol generates acetaldehyde, a toxic metabolite. In addition, chronic alcohol abuse seems to favor colonization by Helicobacter pylori, which produces ammonia that also contributes to the commonly associated chronic gastritis. Because antibiotics were shown over the last 4 decades to effectively eliminate gastric ammonia, they should be considered for the routine treatment of such chronic gastritis in the way they are now being used for ulcer therapy.
Lieber
C S
CS
Department of Medicine and Pathology, Mount Sinai School of Medicine, Bronx, New York, USA.
D000426:Alcohol Dehydrogenase / Q000502:physiology; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004357:Drug Synergism; D000431:Ethanol / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology; D005756:Gastritis / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology*; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy / Q000201:enzymology; D016480:Helicobacter pylori; D006801:Humans; D008657:Metabolic Clearance Rate / Q000187:drug effects
D000897:Anti-Ulcer Agents; D000431:Ethanol; D000426:Alcohol Dehydrogenase