Paradoxical behavioral response to apomorphine in tenascin-gene knockout mouse.
Tenascin is a large extracellular matrix glycoprotein which is highly expressed in the developing nervous system. To examine the role of tenascin in vivo, we have produced mice in which the tenascin-gene is inactivated. These animals did not easily habituate to unfamiliar circumstances and displayed hyperlocomotion. A dopamine receptor agonist, apomorphine, reduced this hyperlocomotion dose dependently, but this phenomenon was not due to the appearance of apomorphine-induced stereotypic behavior, suggesting that tenascin-gene mutant mice have a paradoxical behavioral response to apomorphine compared to wild-type mice.
Fukamauchi
F
F
Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, Japan.
Wang
Y J
YJ
Mataga
N
N
Kusakabe
M
M
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008124:Locomotion / Q000187:drug effects / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D013045:Species Specificity; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology; D019063:Tenascin / Q000235:genetics / Q000502:physiology*
D018491:Dopamine Agonists; D019063:Tenascin; D001058:Apomorphine