Increased prevalence of infectious diseases and other adverse outcomes in human T lymphotropic virus types I- and II-infected blood donors. Retrovirus Epidemiology Donor Study (REDS) Study Group.
Disease associations of human T lymphotropic virus types I and II (HTLV-I and -II) infection were studied in 154 HTLV-I-infected, 387 HTLV-II-infected, and 799 uninfected blood donors. Adjusted odds ratios (ORs) and 99% confidence intervals (CIs) were derived from logistic regression models controlling for demographics and relevant confounders. All subjects were human immunodeficiency virus type 1-seronegative. HTLV-II was significantly associated with a history of pneumonia (OR, 2.6; 99% CI, 1.2-5.3), minor fungal infection (OR, 2.9; 99% CI, 1.2-7.1), and bladder or kidney infection (OR, 1.6; 99% CI, 1.0-2.5) within the past 5 years and with a lifetime history of tuberculosis (OR, 3.9; 99% CI, 1.3-11.6) and arthritis (OR, 1.8; 99% CI, 1.2-2.9). Lymphadenopathy (> or =1 cm) was associated with both HTLV-I (OR, 6.6; 99% CI, 2.2-19.2) and HTLV-II (OR, 2.8; 99% CI, 1.1-7.1) infection, although no case of adult T cell leukemia/lymphoma was diagnosed. Urinary urgency and gait disturbance were associated with both viruses. This new finding of increased prevalence of a variety of infections in HTLV-II-positive donors suggests immunologic impairment.
Murphy
E L
EL
Department of Laboratory Medicine, University of California, San Francisco 94143-0884, USA.
Glynn
S A
SA
Fridey
J
J
Sacher
R A
RA
Smith
J W
JW
Wright
D J
DJ
Newman
B
B
Gibble
J W
JW
Ameti
D I
DI
Nass
C C
CC
Schreiber
G B
GB
Nemo
G J
GJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000150:complications / Q000453:epidemiology; D001782:Blood Donors; D015331:Cohort Studies; D005260:Female; D015490:HTLV-I Infections / Q000150:complications* / Q000453:epidemiology; D015491:HTLV-II Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007239:Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000453:epidemiology; D016015:Logistic Models; D008206:Lymphatic Diseases / Q000150:complications / Q000821:virology; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications / Q000453:epidemiology; D016017:Odds Ratio; D011014:Pneumonia / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D014376:Tuberculosis / Q000150:complications / Q000453:epidemiology; D014570:Urologic Diseases / Q000150:complications / Q000453:epidemiology