Alpha1-antichymotrypsin polymorphism in Japanese cases of Alzheimer's disease.
We examined the possible involvement of alpha1-antichymotrypsin (ACT) polymorphism in the risk for Alzheimer's disease (AD) in a Japanese population. No differences between AD and control subjects have been shown in the genotype distributions and allele frequencies of ACT. No modification of the risk for AD was observed, either alone or in combination with the apolipoprotein epsilon4 (ApoE-4) allele. Our results from a Japanese population failed to confirm the previous data in which the ACT polymorphism was shown to affect the ApoE-4-associated risk for AD.
Yoshizawa
T
T
Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Japan. toshi-yo@md.tsukuba.ac.jp
Yamakawa-Kobayashi
K
K
Hamaguchi
H
H
Shoji
S
S
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D012016:Reference Values; D000514:alpha 1-Antichymotrypsin / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000514:alpha 1-Antichymotrypsin; C046545:CCWGG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific