Orthotopic transplantation of a partial hepatic autograft in dogs.
The purpose of this study was to investigate the availability of an orthotopic transplantation of partial hepatic autograft in dogs as a means of surgical training. Male mongrel dogs weighting 10-15 kg were used. The left lobe of the liver was harvested while preserving the left branches of the portal vein, hepatic artery and bile duct, and the left hepatic vein. The remnant liver was removed while preserving the inferior vena cava using a veno-venous bypass. Orthotopic transplantation of the autograft was performed while anastomosing the left hepatic vein to the inferior vena cava, portal and arterial reconstruction, and external biliary drainage. Thirteen out of 29 dogs survived more than 48 h after transplantation. However, 6 out of 13 dogs were sacrificed after developing bile peritonitis due to a dislodgement of the biliary catheter, and only two dogs were able to survive for 7 days after transplantation. The arterial ketone body ratio recovered to 1.0 within 1 h after reperfusion, and the ratio of the dogs that survived for more than 48 h remained above 1.0 until sacrifice. Orthotopic transplantation of a partial hepatic autograft is a useful and simple procedure to train surgeons for partial liver transplantation.
Kasai
S
S
Second Department of Surgery, Asahikawa Medical College, Hokkaido, Japan.
Sawa
M
M
Yamamoto
T
T
Hirai
S
S
Mamiya
N
N
Tomita
I
I
Mito
M
M
D000818:Animals; D002983:Clinical Competence; D004285:Dogs; D007657:Ketone Bodies / Q000097:blood; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D011170:Portasystemic Shunt, Surgical; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous
D007657:Ketone Bodies