Multiple gastric carcinoids and pituitary adenoma in type A gastritis.
A 48-year-old male with type A atrophic gastritis developed multiple gastric carcinoids and a pituitary adenoma. Laboratory tests revealed high levels of serum gastrin and growth hormone (GH). He underwent subtotal gastrectomy, resulting in a return of the previously elevated gastrin level to normal. Serum GH concentration remained high. Three months after the surgery, the pituitary tumor, composed greatly of GH-immunoreactive cells, was partially removed. Since hypergastrinemia plays a pivotal role in gastric carcinoid formation and induces GH-releasing factor (GHRH) release resulting in GH-producing pituitary tumor formation, GH-producing pituitary adenoma might be a clinical manifestation in type A gastritis.
Kojima
K
K
Department of Internal Medicine, Tamano Mitsui Hospital, Okayama.
Miyake
M
M
Nakagawa
H
H
Yunoki
Y
Y
Ogurusu
K
K
Saino
S
S
Wani
T
T
Kawaguchi
Y
Y
D000236:Adenoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002276:Carcinoid Tumor / Q000097:blood / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D005743:Gastrectomy; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000150:complications*; D005773:Gastroscopy; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism; D013007:Growth Hormone-Releasing Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013274:Stomach Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D005755:Gastrins; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone