title: Combined effect of HLA-DRB1*1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis.
abstract: Susceptibility to multiple sclerosis (MS) is associated with HLA-DRB1*1501. Many reports have suggested associations with other loci but these results remain unconfirmed. We studied the IL-1 receptor antagonist (IL-1ra) gene polymorphism and the HLA-DR and DQ allele frequencies by DNA-based methods in both the primary chronic progressive form (PP MS) and the relapsing/remitting form (R/R MS). The frequency of DRB1*1501 and IL-1ra allele 2 were significantly higher in R/R MS. Association was more marked in the female sex and in patients with benign forms of R/R MS. On the other hand DR4 subtypes carrying a Val at position 86 in the DR beta chain were increased in PP MS. The present study indicates that MS is genetically heterogeneous and shows a combined effect of HLA-DR and IL-1ra genes in susceptibility to the R/R form of the disease.
authors.affiliation: Department of Immunology, San Carlos University Hospital, Madrid, Spain.
authors.forename: E G
authors.initials: EG
authors.lastname: de la Concha
authors.forename: R
authors.initials: R
authors.lastname: Arroyo
authors.forename: J B
authors.initials: JB
authors.lastname: Crusius
authors.forename: J A
authors.initials: JA
authors.lastname: Campillo
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: E
authors.initials: E
authors.lastname: Varela de Seijas
authors.forename: A S
authors.initials: AS
authors.lastname: Peña
authors.forename: L E
authors.initials: LE
authors.lastname: Clavería
authors.forename: M
authors.initials: M
authors.lastname: Fernandez-Arquero
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D011897:Random Allocation; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors* / Q000235:genetics*; D012008:Recurrence; D012720:Severity of Illness Index; D012737:Sex Factors; D012795:Sialoglycoproteins / Q000235:genetics*; D013030:Spain / Q000453:epidemiology
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins