title: [Effect of a local nonsteroidal anti-inflammatory drug on postoperative irritation after squint surgeries. Prospective randomized double-blind study].
abstract: BACKGROUND
  Topical application of a nonsteroidal antiphlogistic drug (NSAD) is often recommended to minimize postoperative lid and conjunctival edema. However, the effectiveness of such therapy remains controversial.
  
  
  METHODS
  The study presented included 100 patients aged 23.6 +/- 19.5 (5 to 77) years, who were randomly assigned to two treatment groups. Group 1 included 50 patients who underwent squint surgery, and who received Flurbiprofen ED twice a day from the first preoperative day to the third postoperative day. Group 2 served as a control group. These patients were treated with the same regimen using artificial tears. The extent of lid and conjunctival edema was assessed and scored from 1 to 4 on the fourth postoperative day.
  
  
  RESULTS
  Squint surgery was performed on 129 eyes of 100 patients. In 32 eyes (24.8%) one muscle was operated on. In 79 eyes (61.2%) 2 muscles and in 18 eyes (14%) three muscles were operated on. The average postoperative conjunctival edema score was 2.08 +/- 0.62 (Flurbiprofen group) and 2.04 +/- 0.67 (control group), respectively. The scoring values for lid edema were 1.90 +/- 0.54 and 1.82 +/- 0.43. The differences between the two groups were not statistically significant (P = 0.21 and 0.39; Mann-Whitney test). No influence of the patient's age on the development of lid and conjunctival edema could be detected (P > 0.08). However, the number of muscles that were operated on had a significant influence on both parameters (P = 0.01 and 0.028). Single muscle operations revealed the lowest scaling values (P < 0.02 and P < 0.04). No difference was found whether 2 or 3 muscles were operated on (P = 0.24 and 0.12).
  
  
  CONCLUSIONS
  No beneficial effect of topical application of NSAD on postoperative lid and conjunctival edema could be found in this controlled study.
authors.affiliation: Universitäts-Augenklinik Heidelberg.
authors.forename: H
authors.initials: H
authors.lastname: Steffen
authors.forename: C
authors.initials: C
authors.lastname: Böhm
authors.forename: G U
authors.initials: GU
authors.lastname: Auffarth
authors.forename: G H
authors.initials: GH
authors.lastname: Kolling
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003229:Conjunctival Diseases / Q000188:drug therapy*; D004311:Double-Blind Method; D004487:Edema / Q000188:drug therapy*; D005141:Eyelid Diseases / Q000188:drug therapy*; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011183:Postoperative Complications / Q000188:drug therapy*; D011446:Prospective Studies; D013285:Strabismus / Q000601:surgery*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D005480:Flurbiprofen