Rapid determination of 1,4-dioxane in water by solid-phase extraction and gas chromatography-mass spectrometry.
A highly sensitive and accurate gas chromatography-mass spectrometry method for rapidly quantitative analysis of dioxane in water samples is described. Dioxane in water sample was extracted by hexane-methylene chloride (80:20, v/v) then transferred to a C18 solid-phase extraction (SPE) cartridge and eluted by acetonitrile. An aliquot of this solution was analyzed by gas chromatography-mass spectrometry with electron impact ionization and selected ion monitoring (dioxane m/z 88) mode. The quantitative limit was set to be 0.05 microgram/ml with an injection volume of 2 microliters and a sample volume of 1 ml. The isotopically labelled [2H8]dioxane (m/z 96) was used as internal standard. Analysis time is approximately 6 min. The results for various kinds of SPE cartridges in this method are also discussed.
Song
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D
Clinical Research Associates, New York, NY 10010, USA.
Zhang
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S
D002274:Carcinogens, Environmental / Q000032:analysis*; D004146:Dioxanes / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D012680:Sensitivity and Specificity; D014874:Water Pollutants, Chemical / Q000032:analysis*
D002274:Carcinogens, Environmental; D004146:Dioxanes; D014874:Water Pollutants, Chemical; C025223:1,4-dioxane