title: Renal transplantation performed across a positive crossmatch: a single centre experience.
abstract: The importance of certain positive crossmatches (CM+) in kidney transplantation remains controversial. Fifty consecutive kidney transplants were performed across a CM+ between Jan. 1990-April 1994. In 19 cases there was an isolated B-cell CM+ (Group I), in 24 an historic T-cell IgM CM+ (Group II) and in 7 an historic T-cell IgG CM+ (Group III). Comparing groups I:II:III: early acute rejection affected 32%, 42%, 57% of grafts; mean serum creatinine at 3 months was 166, 150, 229 umol/l (p < 0.05); 1 yr graft survival was 95 per cent, 96 per cent, 71 per cent (p = 0.09). In group III both graft losses were in the setting of an additional current B-cell CM+.
  
  
  CONCLUSIONS
  Transplantation performed in either the presence of an isolated B-cell CM+ or in the presence of an historic T-cell IgM CM+ was associated with acceptable outcomes at 1 yr. An historic T-cell IgG CM+ was confirmed as a contraindication to transplantation in most circumstances, especially when coupled with a current B-cell CM+.
authors.affiliation: Department of Nephrology, Beaumont Hospital, Dublin, Ireland.
authors.forename: S F
authors.initials: SF
authors.lastname: Leavey
authors.forename: J J
authors.initials: JJ
authors.lastname: Walshe
authors.forename: D
authors.initials: D
authors.lastname: O'Neill
authors.forename: N
authors.initials: N
authors.lastname: Atkins
authors.forename: J
authors.initials: J
authors.lastname: Donohoe
authors.forename: D
authors.initials: D
authors.lastname: Hickey
authors.forename: M
authors.initials: M
authors.lastname: Carmody
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D000075202:Contraindications; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M