Derivatives of 2-mercaptobenzenesulphonamide. XIX. Syntheses, anticancer and anti-HIV activities of some 2-(4-chloro-2-mercaptobenzenesulphonylimino) perhydropyrimidines.
Syntheses of some 2-(4-chloro-2-mercaptobenzenesulphonylimino)perhydropyrimidine+ ++ derivatives are described. The moderate anticancer and weak anti-HIV activities were observed in vitro for compounds [IX-XI].
Pomarnacka
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Department of Chemical Drug Technology, Medical University of Gdańsk, Poland.
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D013438:Sulfhydryl Compounds; D013449:Sulfonamides