Evaluation of urinary enzymes in renal allograft damages by histology examination.
Acute allograft rejection (ARE) is one of the most current problem in kidney transplantation. Urinary enzymes (glutathione-S-transferase /GST/. dipeptidil-dipeptidase /DPP/) are frequently used as prognostic factors of ARE. The authors compared the results of light microscopic study (by Banff scheme), and the GST, and DPP secretion in acute rejection. The correlation between the laboratory, and histology findings wasn't significant. our results suggest that both GST, and DPP are very sensitive, but less specific indicators in ARE, since their activity increases in many other damages as well.
Nemes
B
B
Transplantation and Surgical Clinic, Semmelweis University of Medicine, Budapest, Hungary.
Sárváry
E
E
Lázár
N
N
Dallos
G
G
Járay
J
J
Perner
F
F
Sulyok
B
B
Takács
L
L
D000208:Acute Disease; D015415:Biomarkers / Q000652:urine; D001706:Biopsy; D002908:Chronic Disease; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000652:urine*; D005260:Female; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000652:urine*; D006084:Graft Rejection / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D007511:Ischemia / Q000201:enzymology / Q000473:pathology; D007527:Isoenzymes / Q000652:urine; D016030:Kidney Transplantation / Q000473:pathology*; D007684:Kidney Tubules / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014184:Transplantation, Homologous
D015415:Biomarkers; D007527:Isoenzymes; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases