title: Computer-aided detection of clustered microcalcifications in digitized mammograms.
abstract: OBJECTIVE
  We investigated a computer-aided detection (CAD) scheme for clustered microcalcifications in digitized mammograms.
  
  
  METHODS
  A multistage CAD scheme was developed and tested. To increase sensitivity, the scheme uses a Gaussian band-pass filter and nonlinear threshold. A multistage local minimum searching routine and a multilayer topographic feature analysis are used to reduce the false-positive detection rate. One hundred ten digitized mammograms were used in this preliminary test, with 55 images containing one or two verified microcalcification clusters.
  
  
  RESULTS
  The CAD scheme achieved 100% sensitivity and had an average false-positive detection rate of 0.18 per image.
  
  
  CONCLUSIONS
  The CAD scheme performs as well as many published schemes and has some unique advantages to further improve detection sensitivity and specificity of future CAD schemes.
authors.affiliation: Department of Radiology, University of Pittsburgh, PA 15261-0001, USA.
authors.forename: B
authors.initials: B
authors.lastname: Zheng
authors.forename: Y H
authors.initials: YH
authors.lastname: Chang
authors.forename: M
authors.initials: M
authors.lastname: Staiger
authors.forename: W
authors.initials: W
authors.lastname: Good
authors.forename: D
authors.initials: D
authors.lastname: Gur
mesh_terms: D001941:Breast Diseases / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000000981:diagnostic imaging*; D003936:Diagnosis, Computer-Assisted; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods* / Q000706:statistics & numerical data; D015588:Observer Variation; D012372:ROC Curve; D011856:Radiographic Image Enhancement; D011897:Random Allocation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity