Prior infection with cytomegalovirus is not a major risk factor for angiographically demonstrated coronary artery atherosclerosis.
To determine if cytomegalovirus (CMV) infection is a risk factor for primary coronary artery disease (CAD), the association between CMV infection and CAD (>50% blockage in any coronary artery) was investigated in nearly 900 successive nontransplant patients undergoing coronary angiography. By use of logistic regression, older age (P <.001), white race (P <.001), gender (P <.001), hypercholesterolemia (P = .04), and other established cardiovascular risk factors (P = .003) were identified as significantly associated with CAD, but CMV seropositivity (P = .462), the level of IgG antibodies to CMV whole cell antigen (P = .98), or the levels of IgG antibodies to CMV glycoprotein B (P = .67) were not. These data suggest that CMV infection is not a major risk factor for the development of primary CAD in adults.
Adler
S P
SP
Department of Pediatrics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0163, USA. sadler@gems.vcu.edu
Hur
J K
JK
Wang
J B
JB
Vetrovec
G W
GW
D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D017023:Coronary Angiography / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000209:etiology*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology; D005007:Ethnology; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D006937:Hypercholesterolemia; D007074:Immunoglobulin G / Q000032:analysis; D016015:Logistic Models; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012737:Sex Factors
D000914:Antibodies, Viral; D000956:Antigens, Viral; D006023:Glycoproteins; D007074:Immunoglobulin G