title: Application of lipid microspheres containing prostaglandin E1 ointment to peripheral ischemic ulcers.
abstract: BACKGROUND
  The systemic use of prostaglandin E1 (PGE1) in the treatment of peripheral vascular disease is well documented. It is known that the liposomal formulation of some drugs enhances their transdermal absorption.
  
  
  OBJECTIVE
  The potential of topical application of lipid microspheres containing PGE1 (lipo-PGE1) to treat ischemic ulcers was evaluated.
  
  
  METHODS
  Lipo-PGE1 ointment (1 microgram/g) was applied topically to peripheral ischemic ulcers in 10 patients for 5.8 weeks (range 4-9 weeks). The patients were followed up for 6 months, and response was assessed comparing photographs of the lesions.
  
  
  RESULTS
  Nine of 10 patients responded to treatment, but in 3 patients, the ulcers recurred after cessation of treatment.
  
  
  CONCLUSIONS
  It is concluded that lipo-PGE1 ointment provides an alternative to the management of patients with incurable peripheral ischemic ulcers.
authors.affiliation: Department of Surgery, University of Tsukuba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakakibara
authors.forename: T
authors.initials: T
authors.lastname: Jikuya
authors.forename: T
authors.initials: T
authors.lastname: Mitsui
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000527:Alprostadil / Q000008:administration & dosage*; D006801:Humans; D007511:Ischemia / Q000150:complications*; D008055:Lipids; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D009824:Ointments; D012883:Skin Ulcer / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D008055:Lipids; D009824:Ointments; D014665:Vasodilator Agents; D000527:Alprostadil