Cytomegalovirus and HLA-A, B, and DR locus interactions: impact on renal transplant graft survival.
Graft failure rates for renal transplantations performed between 1989 and 1994 and recorded in the US Renal Data System database were retrospectively evaluated for interactions between cytomegalovirus and HLA-A, B, and DR loci. Twelve significant interactions were observed. There were significantly greater risks of graft failure for the total effect of cytomegalovirus and donor or matched HLA-DR9, recipient or matched HLA-B-51, and matched HLA-B13. We conclude that further study of renal transplants with these combinations of cytomegalovirus and HLA loci is needed to determine whether the observed interactions should be taken into consideration when matching donors with recipients.
Schnitzler
M A
MA
Department of Internal Medicine, School of Medicine, Washington University, St Louis, MO 63110, USA. schnitz@wuecona.wustl.edu
Woodward
R S
RS
Brennan
D C
DC
Phelan
D L
DL
Spitznagel
E L
EL
Boxerman
S B
SB
Dunagan
W C
WC
Bailey
T C
TC
D000328:Adult; D002102:Cadaver; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000150:complications*; D019992:Databases as Topic; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059908:HLA-B13 Antigen; D059949:HLA-B51 Antigen; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D006648:Histocompatibility; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D019520:Living Donors; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D017063:Outcome Assessment, Health Care; D010641:Phenotype; D012189:Retrospective Studies; D012307:Risk Factors
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059908:HLA-B13 Antigen; D059949:HLA-B51 Antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C038988:HLA-DR9 antigen