title: Investigations on the synthesis and properties of some N-[4-phenyl(2-pyrimidinyl)-1-piperazinyl]alkyl (hydroxyalkyl)-3,4-pyridinedicarboximides.
abstract: Synthesis of 2-substituted N-(4-phenyl-1 piperazinyl)propyl(butyl)- and N-2-hydroxy-3[4-phenyl(2-pyrimidinyl)-1-piperazinyl]propyl-6-methyl-3,4- pyridinedicarboximides [VI-XIV] is described. Some of them displayed depressive action on the central nervous system.
authors.affiliation: Department of Chemistry of Drugs, Wrocław University of Medicine, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Sladowska
authors.forename: J
authors.initials: J
authors.lastname: Potoczek
authors.forename: G
authors.initials: G
authors.lastname: Rajtar
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: D
authors.initials: D
authors.lastname: Zółkowska
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000494:pharmacology; D007094:Imides / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; D007094:Imides; D011743:Pyrimidines