title: Superoxide generation by monocytes following infection with human cytomegalovirus.
abstract: A significant level of superoxide (O2-) generation was observed in a U937-derived subclone following infection with human cytomegalovirus (HCMV). Although there were no detectable levels of viral mRNA and/or protein expression, HCMV DNA content transiently increased immediately before O2- generation. Similarly, O2- generation was also observed in peripheral blood monocytes derived from healthy donors.
authors.affiliation: Section of Serology, Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Kameoka
authors.forename: T
authors.initials: T
authors.lastname: Nakaya
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: N
authors.initials: N
authors.lastname: Nishi
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: K
authors.initials: K
authors.lastname: Ikuta
mesh_terms: D003587:Cytomegalovirus / Q000235:genetics / Q000378:metabolism; D003586:Cytomegalovirus Infections / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000821:virology; D009000:Monocytes / Q000378:metabolism* / Q000821:virology*; D012333:RNA, Messenger / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*
chemical_list: D004279:DNA, Viral; D012333:RNA, Messenger; D013481:Superoxides