title: Reversible hemiplegia as a consequence of severe hyperkalemia and cocaine abuse in a hemodialysis patient.
abstract: Severe hyperkalemia may cause weakness that typically is ascending and symmetric. In an isolated case report, hemiplegia occurred after the development of hyperkalemia in a patient with a known central nervous system lesion. We describe a patient requiring long-term hemodialysis who had near-fatal hyperkalemia, hemiplegia, and rhabdomyolysis after abuse of crack cocaine. The hemiplegia resolved after normalization of serum potassium using emergency dialysis. No brain lesion could be identified during computed tomography or by electroencephalography, and the patient had no residual neurologic deficits. We conclude that this patient had hemiplegia secondary to cocaine-induced cerebral vasoconstriction because no structural lesion could be found and that the neurologic deficit was worsened by severe hyperkalemia, which probably resulted from cocaine-induced rhabdomyolysis. Hence, despite the absence of a structural lesion of the brain, severe hyperkalemia, typically associated with symmetric, ascending muscle weakness, may contribute to causing focal weakness in the condition of cocaine-induced vasoconstriction.
authors.affiliation: Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York, USA.
authors.forename: C
authors.initials: C
authors.lastname: Effiong
authors.forename: T S
authors.initials: TS
authors.lastname: Ahuja
authors.forename: J D
authors.initials: JD
authors.lastname: Wagner
authors.forename: P C
authors.initials: PC
authors.lastname: Singhal
authors.forename: J
authors.initials: J
authors.lastname: Mattana
mesh_terms: D000328:Adult; D019970:Cocaine-Related Disorders / Q000150:complications*; D016578:Crack Cocaine; D006429:Hemiplegia / Q000209:etiology* / Q000628:therapy; D006801:Humans; D006947:Hyperkalemia / Q000150:complications*; D002546:Ischemic Attack, Transient / Q000209:etiology; D008297:Male; D006435:Renal Dialysis; D012206:Rhabdomyolysis / Q000209:etiology
chemical_list: D016578:Crack Cocaine