Effect of estradiol on serum triglyceride lipoprotein levels and fatty acid composition in castrated rats.
Triglyceride content and fatty acid composition of rat serum lipoproteins showed specific variations after castration and estradiol treatment. Triglyceride levels decreased in VLDL after castration and in LDL and HDL after low doses of estradiol. High doses of estradiol enhanced triglyceride levels in VLDL and decreased them in LDL. Fatty acid composition showed a complex pattern: after castration, monoenoic acids decreased and essential fatty acids increased in all lipoprotein classes, enhancing the EFA/NEFA and EFA/ME ratios. Both doses of estrogen lowered these ratios in VLDL and LDL, but decreased them in HDL with high doses and enhanced them in HDL with low doses.
Ginci
G
G
Institute of Biochemistry and Enzymology, University of Siena, Italy.
Arezzini
L
L
Terzuoli
L
L
Pizzichini
M
M
Marinello
E
E
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood / Q000737:chemistry; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry; D008079:Lipoproteins, VLDL / Q000097:blood / Q000737:chemistry; D008297:Male; D009919:Orchiectomy; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood*
D005227:Fatty Acids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D004958:Estradiol