Pulse dose oral calcitriol therapy for renal osteodystrophy: literature review and practice recommendations.
Oral pulse dosing of calcitriol has been proposed as an alternative to intravenous administration in the treatment of renal osteodystrophy. A review of the literature suggests it can provide a safe and effective method that is especially convenient for peritoneal dialysis patients with mild to moderate bone disease. However, its use should be accompanied by careful monitoring and control of serum calcium, phosphorus, and parathyroid hormone levels. Some practical suggestions are provided.
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College of Pharmacy, Rutgers, the State University of New Jersey in Piscataway, USA.
Foote
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D000284:Administration, Oral; D002117:Calcitriol / Q000008:administration & dosage*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy*; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D007262:Infusions, Intravenous; D010530:Peritoneal Dialysis; D017410:Practice Guidelines as Topic
D002117:Calcitriol