In vitro activities of new quinolones against Helicobacter pylori.
Compounds belonging to a new class of quinolones in which the fundamental C-6 fluorine atom was replaced were evaluated for in vitro antibacterial activity against 32 Helicobacter pylori strains. Since these substitutions resulted in higher inhibitory activities, these new desfluoroquinolones may be useful in eradicating H. pylori infections.
Carbone
M
M
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università di Messina, Italy. Teti@eniware.it
Fera
M T
MT
Cecchetti
V
V
Tabarrini
O
O
Losi
E
E
Cusumano
V
V
Teti
G
G
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D042462:4-Quinolones; D000890:Anti-Infective Agents