Immunoregulatory activities of L-4-oxalysine: an in vitro study.
The present study was undertaken by in vitro experiments to determine the effect of L-4-oxalysine (OXL), a new natural product in China, on immunological responses. The immunological parameters evaluated were one-way mixed lymphocyte reaction and interleukin-6 activity stimulated by lipopolysaccharide. The results showed that the immunological functions of spleen cells from normal mice were significantly suppressed by in vitro treatment of OXL. However, OXL markedly enhanced the immunological responses of spleen cells from mice bearing hepatoma-22 tumor. It was indicated that OXL exerted obvious immunoregulatory activities.
Wang
X W
XW
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, P.R. China.
Xu
B
B
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000276:immunology; D002478:Cells, Cultured / Q000187:drug effects; D002681:China; D005260:Female; D015850:Interleukin-6 / Q000378:metabolism*; D008070:Lipopolysaccharides; D008114:Liver Neoplasms, Experimental / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed / Q000379:methods; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured; D000093242:Interleukin-6 Inhibitors
D000276:Adjuvants, Immunologic; D000600:Amino Acids, Dicarboxylic; D015850:Interleukin-6; D008070:Lipopolysaccharides; D000093242:Interleukin-6 Inhibitors; C027136:4-oxalysine