title: Growth inhibition of oral bacteria related to denture stomatitis by anti-candidal chalcones.
abstract: In the antimicrobial therapy of denture stomatitis, it is desirable to inhibit the growth of not only the primary causative organism, Candida albicans, but also other oral bacteria closely associated with the condition. Three synthetic anti-candidal chalcones were characterized and compared for their additional activity in inhibiting these causative bacteria. Among the tested chalcones, 2,4,2'-trihydroxy-5'-methylchalcone showed the highest activity for different Gram-positive bacteria. It inhibited the growth of streptococci, staphylococci and lactobacilli at 25.0-50.0 micrograms/mL which was lower than or comparable to its minimum inhibitory concentration for candida. It functioned with a bactericidal action and leaked 260 nm-absorbing substances from the streptococcal cells. The antimicrobial activity of 2,4,2'-trihydroxy-5'-methylchalcone against both primary and secondary causative agents suggests it could be useful as a potent therapeutic agent in denture stomatitis.
authors.affiliation: Department of Oral Microbiology, Asahi University School of Dentistry, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Tsuchiya
authors.forename: M
authors.initials: M
authors.lastname: Akagiri
authors.forename: N
authors.initials: N
authors.lastname: Takagi
authors.forename: M
authors.initials: M
authors.lastname: Iinuma
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects*; D002599:Chalcone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D047188:Chalcones; D004396:Coloring Agents; D004926:Escherichia coli / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D007780:Lacticaseibacillus casei / Q000187:drug effects; D009055:Mouth / Q000382:microbiology; D012706:Serratia marcescens / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013282:Stomatitis, Denture / Q000188:drug therapy / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: C110094:2,4,2'-trihydroxy-5'-methylchalcone; C110093:2,4,2'-trihydroxychalcone; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D047188:Chalcones; D004396:Coloring Agents; D002599:Chalcone; C013031:2'-hydroxychalcone