title: [A case of congenital complete heart block in a mother with anti-52 kD SS-A/Ro antibodies].
abstract: We report a case of congenital complete heart block (CCHB). A 38-year-old woman was admitted our hospital because of fetal bradycardia at 21 weeks 3 days of gestational age. She had no symptom of collagen disease. On admission, laboratory data showed positive anti-nuclear antibodies, anti-SS-A/Ro antibodies and anti-52 kD SS-A/Ro antibodies. But anti-60 kD SS-A/Ro and anti-SS-B/La antibodies were negative. Consequently anti-52 kD SS-A/Ro antibodies positive woman had an infant with CCHB. The baby was equipped with pacemaker at the age of 2 months. This report suggests that anti-52 kD SS-A/Ro antibodies may play an important role in the development of CCHB.
authors.affiliation: Department of Laboratory Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health.
authors.forename: T
authors.initials: T
authors.lastname: Yahara
authors.forename: C
authors.initials: C
authors.lastname: Noda
authors.forename: A
authors.initials: A
authors.lastname: Miyano
authors.forename: T
authors.initials: T
authors.lastname: Miyamichi
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: K
authors.initials: K
authors.lastname: Shinohara
authors.forename: K
authors.initials: K
authors.lastname: Kidoguchi
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D005260:Female; D006327:Heart Block / Q000151:congenital*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
chemical_list: D000974:Antibodies, Antinuclear; C035356:SS-A antibodies