Associations between ADHD and psychoactive substance use disorders. Findings from a longitudinal study of high-risk siblings of ADHD children.
This article investigates the relationship between attention-deficit/hyperactivity disorder (ADHD) and psychoactive substance use disorders (PSUD) in siblings of ADHD and normal-control probands and addresses issues of psychiatric comorbidity and gender. Using DSM-III-R structured diagnostic interviews and blind raters, the authors conducted a 4-year follow-up of siblings. ADHD and male gender predicted higher rates and an earlier onset of PSUD after adjusting for high-risk status, other psychiatric disorders, and age. Risk was particularly high if the siblings had ADHD plus conduct disorder. This study's findings confirms the authors' prior report high-lighting the importance of drug and alcohol prevention and cessation programs aimed at ADHD youth and their siblings, particularly those with comorbid conduct disorder.
Milberger
S
S
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Biederman
J
J
Faraone
S V
SV
Wilens
T
T
Chu
M P
MP
D000293:Adolescent; D019973:Alcohol-Related Disorders / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D002653:Child Behavior Disorders / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D013287:Illicit Drugs; D008297:Male; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs; D012307:Risk Factors; D012737:Sex Factors; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology
D013287:Illicit Drugs; D011619:Psychotropic Drugs