Preparation of polymeric microspheres by the solvent evaporation method using sucrose stearate as a droplet stabilizer.
Polymeric microspheres containing nicardipine hydrochloride (HCl) as a reference drug were prepared with the acrylic polymers Eudragit RS and L by the solvent evaporation method. Different concentrations of sucrose stearate as a droplet stabilizer were used. Sucrose stearate affected the diffusion rate of the solvent from the preliminary emulsion droplets to the outer phase for the formation of microspheres. Increasing concentrations of sucrose stearate in the formulations caused increasing porosity on the surface of the microspheres. However, a correlation between the concentrations of sucrose stearate and diameters of microspheres could not be assessed. From this point of view, during processing, applied stirring rate was important.
Yüksel
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Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Turkey.
Baykara
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T
D004339:Drug Compounding / Q000379:methods; D005079:Excipients / Q000378:metabolism; D008863:Microspheres; D009529:Nicardipine / Q000378:metabolism; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism; D012997:Solvents; D013395:Sucrose / Q000031:analogs & derivatives* / Q000378:metabolism
D005079:Excipients; D011108:Polymers; D012997:Solvents; C018153:sucrose monostearate; D013395:Sucrose; D009529:Nicardipine