title: Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock.
abstract: Inflammation may play an important role in the evolution of damage after traumatic brain injury (TBI). IL-6 and IL-10 are markers of inflammation that are pro- and anti-inflammatory in nature, respectively. They have been used as an index of the degree of inflammation in diseases including sepsis and meningitis. We hypothesized that both IL-6 and IL-10 would be increased in the cerebrospinal fluid (CSF) of children after TBI. We measured ventricular CSF concentrations of these metabolites (ELISA) each of the first 3 days after TBI in 15 children. CSF IL-6 was increased on day 1 (p < 0.05 vs days 2 or 3). CSF IL-10 was similarly increased on day 1 (p < 0.05). CSF IL-6 after TBI is similar to serum IL-6 levels previously reported in children with septic shock. In contrast, the CSF IL-10 response was markedly attenuated following TBI compared to sepsis. These data suggest a unique balance between pro- and anti-inflammatory cytokines in brain after TBI.
authors.affiliation: Safar Center for Resuscitation Research, University of Pittsburgh, PA, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Bell
authors.forename: P M
authors.initials: PM
authors.lastname: Kochanek
authors.forename: L A
authors.initials: LA
authors.lastname: Doughty
authors.forename: J A
authors.initials: JA
authors.lastname: Carcillo
authors.forename: P D
authors.initials: PD
authors.lastname: Adelson
authors.forename: R S
authors.initials: RS
authors.lastname: Clark
authors.forename: M J
authors.initials: MJ
authors.lastname: Whalen
authors.forename: S T
authors.initials: ST
authors.lastname: DeKosky
mesh_terms: D001930:Brain Injuries / Q000134:cerebrospinal fluid*; D002552:Cerebral Ventricles / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000134:cerebrospinal fluid*; D016753:Interleukin-10 / Q000134:cerebrospinal fluid*; D015850:Interleukin-6 / Q000134:cerebrospinal fluid*; D012772:Shock, Septic / Q000134:cerebrospinal fluid*
chemical_list: D015850:Interleukin-6; D016753:Interleukin-10