Urine viscosity after injections of iotrolan or iomeprol.
OBJECTIVE
Previous observations in rats caused us to speculate whether the injection of iotrolan, a nonionic dimeric contrast medium (CM), would increase urine viscosity enough to obstruct urine outflow in the collecting duct.


METHODS
The urine viscosity in dogs was measured directly with a viscosimeter after injections of iotrolan or of iomeprol, a nonionic monomeric CM.


CONCLUSIONS
The injection of iotrolan increased urine viscosity considerably whereas iomeprol had little effect on this variable. The osmolality-dependent adverse reactions of CM have previously been emphasized but viscosity-dependent adverse reactions must also be considered when the CM is a polymer with a low osmolality.
Ueda
J
J
Department of Radiology, Sumitomo Hospital, Nara Medical University, Japan.
Furukawa
T
T
Higashino
K
K
Takahashi
S
S
Araki
Y
Y
Kubo
K
K
Nakashima
T
T
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood / Q000652:urine; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007275:Injections, Intravenous; D007455:Iodine / Q000097:blood / Q000652:urine; D007479:Iopamidol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D007685:Kidney Tubules, Collecting / Q000187:drug effects; D009399:Nephrons / Q000187:drug effects; D009994:Osmolar Concentration; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D014554:Urination / Q000187:drug effects; D014556:Urine / Q000502:physiology*; D014783:Viscosity
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C033300:iotrolan; C057937:iomeprol; D007455:Iodine; D003404:Creatinine; D007479:Iopamidol