The influence of triclosan, zinc or propylene glycol on oral mucosa exposed to sodium lauryl sulphate.
Previous studies on triclosan treatment of skin exposed to sodium lauryl sulphate (SLS) indicated a protective rôle of zinc and an irritant effect of propylene glycol (PG). The aim was hence to examine whether zinc or PG also may affect SLS-induced oral mucosal reactions, and also to test the influence of zinc in combination with triclosan. 15 healthy dental students participated in this double-blind crossover study performed in 2 experimental series. They were rinsing 2x daily with solutions containing (A) 1.5% SLS, (B) 1.5% SLS/0.5% zinc citrate and (C) 1.5% SLS/PG (1:8) in experiment 1, and (D) 1.5% SLS/0.15% triclosan/0.3% zinc citrate and (E) 1.5% SLS/0.15% triclosan in experiment 2. Clinical evaluation by 2 examiners of degree of erythema and oral mucosal desquamations was then performed. The critical micellar concentration was also determined. SLS and SLS/PG, which were not different in effect, evoked significantly more erythematous reactions than SLS/Tri/Zn. This solution was numerically but not statistically better than SLS/Tri, and the latter also did lead to significantly less erythema than SLS/PG. In conclusion, the present study revealed no irritation of the oral mucosa due to PG, whereas a protective effect of zinc as well as the anti-inflammatory effect of triclosan were confirmed.
Skaare
A B
AB
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Norway. askaare@odont.uio.no
Rölla
G
G
Barkvoll
P
P
D000328:Adult; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D018592:Cross-Over Studies; D003879:Dermatologic Agents / Q000494:pharmacology; D004311:Double-Blind Method; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D007509:Irritants / Q000494:pharmacology*; D008297:Male; D009059:Mouth Diseases / Q000139:chemically induced; D009061:Mouth Mucosa / Q000187:drug effects*; D019946:Propylene Glycol / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology*; D013501:Surface-Active Agents / Q000494:pharmacology*; D014260:Triclosan / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D007509:Irritants; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D014260:Triclosan; D019946:Propylene Glycol; D015032:Zinc