Propofol anesthesia and rational opioid selection: determination of optimal EC50-EC95 propofol-opioid concentrations that assure adequate anesthesia and a rapid return of consciousness.
Vuyk
J
J
Department of Anaesthesiology, University Hospital Leiden, The Netherlands. Jvuyk@anst.azl.nl
Mertens
M J
MJ
Olofsen
E
E
Burm
A G
AG
Bovill
J G
JG
D015760:Alfentanil / Q000493:pharmacokinetics / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000493:pharmacokinetics / Q000494:pharmacology*; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics / Q000494:pharmacology*; D003198:Computer Simulation; D004347:Drug Interactions; D005283:Fentanyl / Q000493:pharmacokinetics / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D011336:Probability; D015742:Propofol / Q000493:pharmacokinetics / Q000494:pharmacology*; D017409:Sufentanil / Q000493:pharmacokinetics / Q000494:pharmacology; D013997:Time Factors
D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D015760:Alfentanil; D017409:Sufentanil; D005283:Fentanyl; D015742:Propofol