title: Ten-year experience with craniofacial implants: clinical and experimental results.
abstract: The choice of bone substitute to be used in the cranio-maxillofacial districts raises several problems relating to the biocompatibility and mechanical resistance of the material. Over the past 10 years a total of 245 cranio-maxillofacial skeletal implants have been performed by the Department of Plastic Surgery at Niguarda Ca' Granda Hospital in Milan. The choice of material varied depending on the market availability of products and the experience acquired of both positive results and the onset of short-term and long-term complications. All patients were monitored with a minimum follow-up of 2 years and a maximum of 10 (mean 36 months). The following parameters were taken into account: complications linked to graft contamination, graft extrusion and decubitus, resorption times, degradable materials, resorption of underlying bone tissue and reactivity of the surrounding tissues. Studies on the cell cytohistotoxicity of materials used were performed in parallel by the cell culture laboratory at the Department of Plastic Surgery of Niguarda Hospital, using human keratinocyte and fibroblast cultures.
authors.affiliation: Department of Plastic Surgery University of Milan, Niguarda Ca' Granda Hospital, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Donati
authors.forename: F W
authors.initials: FW
authors.lastname: Baruffaldi-Preis
authors.forename: A
authors.initials: A
authors.lastname: Di Leo
authors.forename: V
authors.initials: V
authors.lastname: Donati
authors.forename: M
authors.initials: M
authors.lastname: Cavallini
authors.forename: M
authors.initials: M
authors.lastname: Marazzi
authors.forename: L
authors.initials: L
authors.lastname: Falcone
mesh_terms: D001672:Biocompatible Materials; D018786:Bone Substitutes; D005145:Face / Q000601:surgery*; D006801:Humans; D008338:Mandibular Injuries / Q000601:surgery; D008439:Maxillary Diseases / Q000601:surgery; D008446:Maxillofacial Injuries / Q000601:surgery*; D009666:Nose / Q000601:surgery; D056948:Orthognathic Surgical Procedures; D011138:Polytetrafluoroethylene / Q000627:therapeutic use; D019736:Prostheses and Implants; D019651:Plastic Surgery Procedures
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011138:Polytetrafluoroethylene