title: Computer simulation of time-gated transillumination and reflection of biological tissues and tissuelike phantoms.
abstract: A simulation technique is employed to explore the possibility of locating millimeter-sized objects, immersed in turbid media, from time-gated measurements of the transmitted or reflected light. The simulation results for tissuelike phantoms are compared to experimental transillumination data and excellent agreement is found. Simulations of time-gated reflection experiments show that it is possible to detect objects of 1 mm diameter. This may open new possibilities for medical diagnosis of breast cancer in an early stage.
authors.affiliation: Institute for Theoretical Physics and Materials Science Centre, University of Groningen, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: Michielsen
authors.forename: H
authors.initials: H
authors.lastname: De Raedt
authors.forename: N
authors.initials: N
authors.lastname: García
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D001943:Breast Neoplasms / Q000175:diagnosis*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008954:Models, Biological; D019047:Phantoms, Imaging; D012984:Software; D014172:Transillumination / Q000379:methods* / Q000706:statistics & numerical data