Idiosyncratic adverse reactions to intramuscular botulinum toxin type A injection.
Three cases of adverse reactions to repeated intramuscular botulinum toxin A (BTA) injections are described: a persistent rash on the face at the site of injection, a localized anaphylactic reaction following BTA injection into one leg, and bilateral ptosis repeatedly following BTA injection into neck muscles. The mechanisms for these idiosyncratic adverse responses are not known.
LeWitt
P A
PA
Clinical Neuroscience Center, Sinai Hospital, West Bloomfield, Michigan, USA.
Trosch
R M
RM
D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects*; D004421:Dystonia / Q000188:drug therapy; D005076:Exanthema / Q000209:etiology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity; D007273:Injections, Intramuscular; D008875:Middle Aged; D014103:Torticollis / Q000188:drug therapy; D014202:Tremor / Q000188:drug therapy
D019274:Botulinum Toxins, Type A