title: Big muscles and big nerves.
abstract: For 11 years, a 50-year-old woman with euthyroid Graves' disease experienced intermittent exacerbations of her orbitopathy associated with a decline in visual acuity. On each occasion, treatment with systemic corticosteroids led to prompt recovery of vision. Upon referral for consideration for orbital decompressive surgery, computed tomography and magnetic resonance imaging scanning detected bilateral optic-nerve sheath meningiomas, as well as typical findings of Graves' disease. Orbital radiation therapy led to stabilization of visual function and orbital findings, eliminating the need for systemic steroids. To our knowledge, this is the first reported case of Graves' disease associated with bilateral optic nerve sheath meningiomas.
authors.affiliation: Eye Foundation Hospital, Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Dabbs
authors.forename: L B
authors.initials: LB
authors.lastname: Kline
mesh_terms: D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D008579:Meningioma / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000473:pathology* / Q000528:radiation effects; D009900:Optic Nerve / Q000473:pathology* / Q000528:radiation effects; D019574:Optic Nerve Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity; D014794:Visual Fields