Chemotherapy-induced myocardial necrosis in a patient with chronic lymphocytic leukemia.
Cardiac toxicity following the administration of chemotherapeutic agents is well documented. Vinca alkaloids, as well as high-dose cyclophosphamide, have been associated with myocardial ischemia. The present report describes a case of acute myocardial infarction occurring in a patient with no antecedent cardiac history who received both vincristine and conventional chemotherapeutic doses of cyclophosphamide for the treatment of chronic lymphocytic leukemia. Physicians should possess a heightened awareness of this potentially serious complication.
Federman
D G
DG
Yale University School of Medicine, General Internal Medicine Section 111, West Haven V.A. Medical Center, CT 06516, USA.
Henry
G
G
D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects*; D004562:Electrocardiography / Q000187:drug effects; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000503:physiopathology; D014750:Vincristine / Q000009:adverse effects*
D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D003520:Cyclophosphamide