[A case of congenital complete heart block in a mother with anti-52 kD SS-A/Ro antibodies].
We report a case of congenital complete heart block (CCHB). A 38-year-old woman was admitted our hospital because of fetal bradycardia at 21 weeks 3 days of gestational age. She had no symptom of collagen disease. On admission, laboratory data showed positive anti-nuclear antibodies, anti-SS-A/Ro antibodies and anti-52 kD SS-A/Ro antibodies. But anti-60 kD SS-A/Ro and anti-SS-B/La antibodies were negative. Consequently anti-52 kD SS-A/Ro antibodies positive woman had an infant with CCHB. The baby was equipped with pacemaker at the age of 2 months. This report suggests that anti-52 kD SS-A/Ro antibodies may play an important role in the development of CCHB.
Yahara
T
T
Department of Laboratory Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health.
Noda
C
C
Miyano
A
A
Miyamichi
T
T
Nakayama
M
M
Shinohara
K
K
Kidoguchi
K
K
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D005260:Female; D006327:Heart Block / Q000151:congenital*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies