title: Molecular phylogeny of glutathione-S-transferases.
abstract: The glutathione-S-transferase (GST) protein superfamily is currently composed of nearly 100 sequences. This study documents a greater phylogenetic diversity of GSTs than previously realized. Parsimony and distance phylogenetic methods of GST amino acid sequences yielded virtually the same results. There appear to be at least 25 groups (families) of GST-like proteins, as different from one another as are the currently recognized classes. This diversity will require the design of a new nomenclature for this large protein superfamily. There is one well-supported large clade containing the mammalian mu, pi, and alpha classes as well as GSTs from molluscs, helminths, nematodes, and arthropods.
authors.affiliation: Bodega Marine Laboratory, University of California, Bodega Bay 94923, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Snyder
authors.forename: D R
authors.initials: DR
authors.lastname: Maddison
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D005982:Glutathione Transferase / Q000145:classification / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment
chemical_list: D005982:Glutathione Transferase