Galanin-acetylcholine interactions in rodent memory tasks and Alzheimer's disease.
Galanin is a 29-amino-acid neuropeptide that is widely distributed in the mammalian central nervous system. Galanin-immunoreactive cell bodies, fibres and terminals, and galanin binding sites, are located in the basal forebrain of rats, monkeys and humans. Galanin fibres hyperinnervate the surviving cholinergic cell bodies in patients with Alzheimer's disease (AD). In rats, galanin inhibits acetylcholine release and produces deficits in learning and memory. These findings suggest that overexpressed galanin may contribute to the cognitive impairments exhibited by patients with AD. This paper reviews the literature on galanin distribution and function in light of its putative role in the mnemonic deficits in patients with AD, the effects of galanin on tests of learning and memory, and preliminary experiments with galanin antagonists in animal models of AD.
McDonald
M P
MP
Section on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, Md. 20892, USA.
Crawley
J N
JN
D000109:Acetylcholine / Q000502:physiology*; D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology*; D000818:Animals; D018680:Cholinergic Antagonists / Q000494:pharmacology; D019004:Galanin / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051381:Rats
D018680:Cholinergic Antagonists; D019004:Galanin; D000109:Acetylcholine