title: Complete cytogenetic but not molecular remission in a patient with myeloid blast crisis of chronic myeloid leukemia treated with carboplatin and ara-C.
abstract: We report on a patient diagnosed with myeloid BC-CML in which a complete cytogenetic remission confirmed by FISH assay was obtained after therapy with carboplatin-ARA-C. However, RT-PCR analysis showed persistence of the p210 bcrabl translocation. Accordingly, the level of residual malignant cells should be between 10(-2) and 10(-6). Autologous stem cell transplantation was performed, but relapse occurred 11 months after blast crisis. This case supports the effectiveness of a carboplatin-ARA-C protocol in BC-CML in order to induce cytogenetic remissions.
authors.affiliation: Servicio de Hematología, Hospital Clinico Universitario de Salamanca, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Pérez-Simón
authors.forename: M D
authors.initials: MD
authors.lastname: Caballero
authors.forename: J M
authors.initials: JM
authors.lastname: Hernandez-Rivas
authors.forename: C
authors.initials: C
authors.lastname: Chillón
authors.forename: M
authors.initials: M
authors.lastname: García-Isidoro
authors.forename: J F
authors.initials: JF
authors.lastname: San Miguel
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000627:therapeutic use*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male
chemical_list: D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine; D016190:Carboplatin