Addition of granulocyte colony-stimulating factor to chemotherapy in patients with AIDS-related lymphoma: effects on neutrophil Fc gamma receptor expression and soluble Fc gammaRIII plasma levels.
AIDS-related neutropenia and neutrophil dysfunction can (partly) be reversed by granulocyte-colony stimulating factor (G-CSF). We studied the effect of G-CSF on neutrophil increment and levels of soluble Fc gamma receptor type III in 15 patients with AIDS-related lymphoma (ARL) undergoing chemotherapy. In six of these patients we performed a detailed kinetic analysis of the membrane expression of the functionally important Fc gamma-receptors type I, II and III. In all these patients G-CSF induced Fc gammaRI positive neutrophils with a decreased expression of the Fc gammaRIII receptor. These changes were similar to those seen both in healthy volunteers and in non-HIV-infected individuals treated with chemotherapy. Interestingly, the mean neutrophil and sFc gammaRIII increment were significantly lower and more patients had a nadir granulocyte count < 0.5 x 10(9)/l after the first cycle than after the second cycle of chemotherapy. This may be related to a therapy-associated decrease in HIV-1 viral load. The conclusion is that patients treated with chemotherapy for ARL have a qualitatively normal response to G-CSF.
Kersten
M J
MJ
Department of Haematology, Academic Medical Centre, Amsterdam, The Netherlands.
de Jong
S
S
Evers
L M
LM
Koene
H R
HR
van Oers
M H
MH
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000378:metabolism; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D015497:HIV-1; D006801:Humans; D007958:Leukocyte Count; D016483:Lymphoma, AIDS-Related / Q000378:metabolism / Q000628:therapy*; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D017452:Receptors, IgG / Q000378:metabolism*
D017452:Receptors, IgG; D016179:Granulocyte Colony-Stimulating Factor