title: Non-viral gene therapy.
abstract: Gene therapy is a medical/surgical intervention currently being developed, in which genes are introduced into cells in order to treat or cure a wide variety of human diseases. The field has evolved over the past four decades, with most experimental gene-therapy studies based on the use of viruses to deliver the genes of therapeutic interest. More recently, a large number of non-viral approaches to gene therapy have emerged, yielding promising pre-clinical results, and which are currently being evaluated in early stage clinical trials.
authors.affiliation: TKT Incorporated, Cambridge, MA 02139, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Treco
authors.forename: R F
authors.initials: RF
authors.lastname: Selden
mesh_terms: D000818:Animals; D018274:Electroporation; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006453:Hemoglobinopathies / Q000235:genetics / Q000628:therapy; D006801:Humans; D014780:Viruses