Treatment of methanol poisoning with intravenous 4-methylpyrazole.
Treatment of human methanol poisoning with the alcohol dehydrogenase inhibitor, 4-methylpyrazole (fomepizole), has not been previously described. We report the clinical and toxicokinetic data of a patient with methanol poisoning who was treated with fomepizole. Formic acid levels remained undetectable during fomepizole treatment, the toxic effects of methanol were prevented, and the patient made a full recovery.
Burns
M J
MJ
Department of Emergency Medicine, University of Massachusetts Medical Center, Worcester, USA. mburns@bidmc.harvard.edu
Graudins
A
A
Aaron
C K
CK
McMartin
K
K
Brent
J
J
D000328:Adult; D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077604:Fomepizole; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D000432:Methanol / Q000493:pharmacokinetics / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy; D011720:Pyrazoles / Q000493:pharmacokinetics / Q000627:therapeutic use*
D004791:Enzyme Inhibitors; D011720:Pyrazoles; D000077604:Fomepizole; D000426:Alcohol Dehydrogenase; D000432:Methanol