title: [Importance and physiologic nutritional requirement of the selenium trace element within the scope of parenteral nutrition (TPN)].
abstract: BACKGROUND
  Selenium-responsive clinical manifestations of selenium deficiency and elucidation of the biochemical and molecular biological basis of the essentiality of selenium give evidence for the biological importance of the trace element in human nutrition.
  
  
  CONCLUSIONS
  The dietary parenteral selenium requirement can be calculated on the basis of the maximal gene expression of the selenoprotein plasma glutathione peroxidase (plGPx). In total parenteral nutrition a daily requirement of 0.01 mumol/kg body weight for adults and 0.025 mumol/kg body weight for children can be seen as adequate and safe.
authors.affiliation: HPN-Centrum, Klinikum Franklin, Freien Universität Berlin. gramm@zop_admin.ukbf.fu-berlin.de
authors.forename: H J
authors.initials: HJ
authors.lastname: Gramm
authors.forename: A
authors.initials: A
authors.lastname: Kopf
authors.forename: P
authors.initials: P
authors.lastname: Brätter
mesh_terms: D000328:Adult; D006801:Humans; D009751:Nutritional Requirements; D016331:Parenteral Nutrition, Home; D010289:Parenteral Nutrition, Total; D011502:Protein-Energy Malnutrition / Q000503:physiopathology / Q000628:therapy; D012643:Selenium / Q000008:administration & dosage* / Q000009:adverse effects / Q000172:deficiency; D014131:Trace Elements / Q000008:administration & dosage* / Q000009:adverse effects / Q000172:deficiency
chemical_list: D014131:Trace Elements; D012643:Selenium