Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees.
Goals of this analysis were to map loci contributing to variation in the quantitative trait, Q1, using the lod-score method on data set 1, and to explore the difference in power to map genes when considering the discrete vs. quantitative phenotype. Segregation analyses, after covariate adjustment, correctly suggested two contributing loci. The major gene on chromosome 5 was successfully mapped, but the major gene on chromosome 8 was not. Comparison of linkage analyses for the qualitative and quantitative traits confirmed that the quantitative trait is more informative, suggesting that localizing disease genes with a qualitative trait would be more difficult in these pedigrees.
Graham
J
J
Department of Biostatistics, University of Washington, Seattle 98195-7720, USA.
Chapman
N H
NH
Goddard
K A
KA
Goode
E L
EL
Wijsman
E M
EM
Jarvik
G P
GP
D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D002898:Chromosomes, Human, Pair 8; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008540:Meiosis / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D019655:Quantitative Trait, Heritable