Rabbit spinal cord infarctuated upon aluminum (III)-liposomes intravenous treatment.
The present paper describes toxic effects of liposomes containing aluminum lactate (AlLac3) (Al-liposomes) on rabbits spinal cord after intravenous treatment of 42 days with 60 micrograms per day of metal-ion as AlLac3 at neutral pH as compared with an aqueous solution of the same metastable Al compound. Among the tissues examined, spinal cord appear to be the most injured one with large infarctual zones where Al is accumulated. Differently, the aqueous solution of AlLac3 is ineffective. Toxic aspects of Al lipophilic forms are herein discussed in terms of pharmacological implications.
Zatta
P
P
CNR Center of Metalloproteins, University of Padova, Venezia, Italy.
Zambenedetti
P
P
Giordano
R
R
Favarato
M
M
D000535:Aluminum / Q000032:analysis; D017607:Aluminum Compounds / Q000008:administration & dosage* / Q000633:toxicity*; D000818:Animals; D002540:Cerebral Cortex / Q000737:chemistry; D004337:Drug Carriers; D006651:Histocytochemistry; D006863:Hydrogen-Ion Concentration; D007238:Infarction / Q000139:chemically induced*; D007773:Lactates / Q000008:administration & dosage* / Q000633:toxicity*; D008081:Liposomes; D008297:Male; D009474:Neurons / Q000473:pathology; D011817:Rabbits; D013116:Spinal Cord / Q000098:blood supply* / Q000737:chemistry / Q000473:pathology
D017607:Aluminum Compounds; D004337:Drug Carriers; D007773:Lactates; D008081:Liposomes; D000535:Aluminum; C104223:aluminum lactate