The role of chromatin in HIV-1 transcriptional regulation.
Regulation of transcription is a key feature of the HIV-1 life cycle. In recent years, various sequence elements and transcription factors have been shown to participate in HIV-1 transcription control. New evidence, however, has shown that chromatin organization plays a key role in the establishment of a transcriptionally regulated HIV-1 LTR. The present review discusses recent data obtained on reconstituted and genomic HIV-1 chromatin templates.
Mirkovitch
J
J
Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland. jmirkovi@isrec.unil.ch
D000818:Animals; D002843:Chromatin; D018983:DNA Footprinting; D003850:Deoxyribonuclease I / Q000378:metabolism; D005544:Forecasting; D015967:Gene Expression Regulation, Viral; D015696:Gene Products, tat / Q000378:metabolism; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D009707:Nucleosomes; D010441:Peptide Chain Elongation, Translational; D011506:Proteins / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D054322:tat Gene Products, Human Immunodeficiency Virus
D002843:Chromatin; D015696:Gene Products, tat; D009707:Nucleosomes; D011506:Proteins; D014157:Transcription Factors; D054322:tat Gene Products, Human Immunodeficiency Virus; D003850:Deoxyribonuclease I