The changes of LCGU and rCBF in the MCA occlusion-recirculation model in rats and the ameliorating effect of MCI-186, a novel free radical scavenger.
We examined the change of regional cerebral blood flow (rCBF) and local cerebral glucose utilization (LCGU) in the middle cerebral artery (MCA) occlusion or recirculation model of rats, and tested anti-ischemic effects of a free radical scavenger, 3-methyl-1-phenyl-pyrazolon-5-one (MCI-186). A remarkable increase in LCGU was observed in the cortex supplied by the anterior cerebral artery after recirculation. This hypermetabolism of glucose was at least partly caused by the postischemic oxidative injury, since MCI-186 ameliorated the high LCGU in this area. These results suggested the usefulness of this type of free radical scavenger for inhibiting the postischemic injury.
Yuki
S
S
Pharmaceuticals Laboratory 1, Mitsubishi Chemical Corporation, Yokohama, Japan. walrus@rc.m-kagaku.co.jp
Kogure
K
K
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D002545:Brain Ischemia / Q000378:metabolism / Q000503:physiopathology*; D002536:Cerebral Arteries / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015424:Reperfusion
D016166:Free Radical Scavengers; D005947:Glucose; D000077553:Edaravone; D000983:Antipyrine