title: Biodistribution of 123I-labeled 4-hydroxytamoxifen derivatives in rats with dimethylbenzanthracene-induced mammary carcinomas.
abstract: A 123I-labeled tamoxifen derivative with a high affinity for the antiestrogen-binding site (AEBS) has been prepared. Biodistribution studies in rats showed a good linear correlation between the AEBS contents of tissue in fmol/g and the accumulated amount of radioactivity in percent dose per gram at 24 h.
authors.affiliation: Radionuclide Centre, Free University, Amsterdam, The Netherlands.
authors.forename: P S
authors.initials: PS
authors.lastname: Kruijer
authors.forename: R P
authors.initials: RP
authors.lastname: Klok
authors.forename: C D
authors.initials: CD
authors.lastname: van den Koedijk
authors.forename: M A
authors.initials: MA
authors.lastname: Blankenstein
authors.forename: J H
authors.initials: JH
authors.lastname: Voskuil
authors.forename: J F
authors.initials: JF
authors.lastname: Verzeijlbergen
authors.forename: G J
authors.initials: GJ
authors.lastname: Ensing
authors.forename: J D
authors.initials: JD
authors.lastname: Herscheid
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001665:Binding Sites; D002273:Carcinogens; D004965:Estrogen Antagonists / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics*; D005260:Female; D007457:Iodine Radioisotopes / Q000737:chemistry; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D002273:Carcinogens; D004965:Estrogen Antagonists; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013629:Tamoxifen; C016601:afimoxifene; D015127:9,10-Dimethyl-1,2-benzanthracene