title: Transneuronal retrograde degeneration of retinal ganglion cells following cerebral hemispherectomy in cats.
abstract: We have assessed the extent of transneuronal retrograde degeneration of retinal ganglion cells (RGCs) following the removal of a whole cerebral hemisphere at postnatal age 16 and 25 days. In the P16 animal, the nasal retina contralateral to the lesion suffered a 41% cell loss, whereas cell loss in the temporal retina ipsilateral to the lesion was 33%. Cell loss was greater in nasal retina and mainly included medium sized cells (200-600 microns2). In the P25 animal overall there was no evidence for ganglion cell loss.
authors.affiliation: Groupe de Recherche en Neuropsychologie Expérimentale, Université de Montréal, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Théoret
authors.forename: M
authors.initials: M
authors.lastname: Herbin
authors.forename: D
authors.initials: D
authors.lastname: Boire
authors.forename: M
authors.initials: M
authors.lastname: Ptito
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology*; D002415:Cats; D002452:Cell Count; D048429:Cell Size / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D009410:Nerve Degeneration / Q000473:pathology / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000502:physiology* / Q000648:ultrastructure