Amino acids and peptides. XXXII: A bifunctional poly(ethylene glycol) hybrid of fibronectin-related peptides.
An amino acid type poly(ethylene glycol) (aaPPEG) was prepared and its application to a drug carrier was examined. The peptides, Arg-Gly-Asp (RGD) and Glu-Ile-Leu-Asp-Val (EILDV) which were reported as active fragments of Fibronectin (a cell adhesion protein), were conjugated with aaPEG (molecular weight, 10,000). The hybrid, RGD-aaPEG-EILDV, was prepared by a combination of the solid-phase method and the solution method. Antiadhesive activity of the peptides was not lost by its hybrid formation with the large aaPEG molecule. A mixture of RGD (0.43 mmol) and EILDV (0.43 mmol) did not demonstrate an antiadhesive effect, but the hybrid containing 0.43 mmol of each peptide did exhibit this effect.
Maeda
M
M
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Japan.
Izuno
Y
Y
Kawasaki
K
K
Kaneda
Y
Y
Mu
Y
Y
Tsutsumi
Y
Y
Lem
K W
KW
Mayumi
T
T
D002352:Carrier Proteins / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects*; D015815:Cell Adhesion Molecules / Q000494:pharmacology*; D004337:Drug Carriers / Q000494:pharmacology; D005353:Fibronectins / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*
D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D004337:Drug Carriers; D005353:Fibronectins; D009842:Oligopeptides; C094697:glutamyl-isoleucyl-leucyl-aspartyl-valine; D011092:Polyethylene Glycols; C047981:arginyl-glycyl-aspartic acid