title: Transurethral prostatectomy in patients with preoperative bacteriuria: double-blind study with oral fleroxacin and cefalexin.
abstract: We compared oral fleroxacin and cefalexin in the prevention of postoperative infectious complications after transurethral prostatectomy (TURP) in patients with preoperative bacteriuria. 95 patients underwent TURP due to benign prostatic hyperplasia with preoperative bacteriuria. The therapy consisted of 7 days of oral fleroxacin 400 mg once a day or cefalexin 500 mg three times daily. After 2 weeks, 62% of the urine samples were sterile in the fleroxacin groups but only 37% in the cefalexin group (p = 0.047). Patients in the cefalexin group had also statistically significantly more symptoms of urinary tract infections. After 6 weeks, the bacterial eradication rate was 53% in the fleroxacin group and 37% in the cefalexin group. There were no septicemias. TURP can be performed with reasonable safety with this oral antibiotic therapy.
authors.affiliation: North Karelian Central Hospital, Joensuu, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Viitanen
authors.forename: K
authors.initials: K
authors.lastname: Malminiemi
authors.forename: J
authors.initials: J
authors.lastname: Kallio
authors.forename: V M
authors.initials: VM
authors.lastname: Puolakka
authors.forename: P
authors.initials: P
authors.lastname: Rajala
authors.forename: T L
authors.initials: TL
authors.lastname: Tammela
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001437:Bacteriuria / Q000188:drug therapy*; D002506:Cephalexin / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004311:Double-Blind Method; D016576:Fleroxacin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care; D011446:Prospective Studies; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000601:surgery
chemical_list: D000890:Anti-Infective Agents; D002511:Cephalosporins; D016576:Fleroxacin; D002506:Cephalexin