DNA polymorphism analysis of a case of complete hydatidiform mole coexisting with a fetus.
A complete hydatidiform mole coexisting with a fetus is a rare condition. The diagnosis is often difficult because of the morphological similarity to a partial mole, but is crucial to management in the postmolar course. We present a case of molar pregnancy coexisting with a fetus in which DNA polymorphism analysis revealed a different genetic origin for the fetal and molar parts. This is the only known case of a complete mole in a twin pregnancy complicated by pre-eclampsia followed by maternal pulmonary oedema. During follow-up, the patient developed a clinically invasive mole which was successfully treated with chemotherapy. In this case, genetic analysis unequivocally diagnosed a twin pregnancy consisting of a complete hydatidiform mole and a fetus.
Harada
I
I
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
Tsutsumi
O
O
Takai
Y
Y
Iida
T
T
Sakai
M
M
Yoshikawa
H
H
Taketani
Y
Y
D000328:Adult; D004247:DNA / Q000235:genetics*; D005260:Female; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011256:Pregnancy Outcome; D014427:Twins
D004247:DNA