[The diffusion and dissolution of metronidazole and doxepin in semisolid pharmaceutical forms through synthetic membranes].
The dissolution and diffussion methods through homogeneous synthetic membrane were studied in different semisolid topical formulations containing metronidazole and doxepin. The results suggest that the rate of release showed a first order kinetic for one of the formulations and the rate of release described by Higuchi for the others.
Széliga
M E
ME
Dpto. Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Lamas
M C
MC
Lillo
D A
DA
Bregni
C
C
D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000737:chemistry*; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000737:chemistry*; D004058:Diffusion; D004316:Doxepin / Q000008:administration & dosage / Q000737:chemistry*; D008567:Membranes, Artificial; D008795:Metronidazole / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility
D000929:Antidepressive Agents, Tricyclic; D000981:Antiprotozoal Agents; D008567:Membranes, Artificial; D008795:Metronidazole; D004316:Doxepin