beta-carotene: friend or foe?
This symposium focused on the research which documents benefit and toxicity in beta-carotene supplementation. Reflecting on past and current studies, the panel of experts discussed: (1) the potential harm of a high intake of beta-carotene on selected populations, (2) biochemical antioxidant/prooxidant mechanisms of beta-carotene at the cellular level, (3) potential benefits of other carotenoids and antioxidants, and (4) future directions for research in beta-carotene and other antioxidants.
Omaye
S T
ST
University of Nevada, Reno 89557, USA.
Krinsky
N I
NI
Kagan
V E
VE
Mayne
S T
ST
Liebler
D C
DC
Bidlack
W R
WR
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D002338:Carotenoids / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D000075202:Contraindications; D019587:Dietary Supplements; D004812:Epidemiologic Methods; D005231:Fatty Acids, Unsaturated; D005456:Fluorescent Dyes; D005544:Forecasting; D005609:Free Radicals; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control; D018384:Oxidative Stress; D016032:Randomized Controlled Trials as Topic; D012907:Smoking; D013329:Structure-Activity Relationship; D019207:beta Carotene / Q000494:pharmacology* / Q000633:toxicity
D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D005456:Fluorescent Dyes; D005609:Free Radicals; D019207:beta Carotene; D002338:Carotenoids; C013641:parinaric acid