Mueggelone, a novel inhibitor of fish development from the fresh water cyanobacterium Aphanizomenon flos-aquae.
A novel C18 lipid, containing a 10-membered lactone, mueggelone (1), was isolated from a field-collected sample of Aphanizomenon flos-aquae, together with the known compound lupenyl acetate (3). Both structures were secured using extensive spectroscopic analysis (1D and 2D NMR, MS, IR). Biological activity assessment of both compounds indicated them to have significant inhibitory effects on fish embryo larval development.
Papendorf
O
O
Institute for Pharmaceutical Biology, Technical University of Braunschweig, Germany.
König
G M
GM
Wright
A D
AD
Chorus
I
I
Oberemm
A
A
D000818:Animals; D000458:Cyanobacteria / Q000737:chemistry / Q000378:metabolism*; D005399:Fishes / Q000254:growth & development*; D006131:Growth Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects / Q000254:growth & development
D006131:Growth Inhibitors; D007783:Lactones; C110081:mueggelone