title: Effects of irradiation on the biomechanics of osseointegration. An experimental in vivo study in rats.
abstract: The present study reports on the late effects of increasing doses of radiation on the biomechanics of commercially pure titanium implants (fixtures) installed in the proximal tibia in 26 rats. Twelve weeks after various doses (10, 20, 30, and 35 Gy) of irradiation, the fixtures were inserted into rat tibiae, and after another eight weeks these were tested mechanically in vivo. Acute dose dependent skin reactions developed after all doses except 10 Gy, but most subsided within two to three weeks. There was a statistically significant reduction in torsion but the pull-out load was not significantly reduced for single doses up to 30 Gy. Histological analysis showed that bone remodelling was impaired. Shear stresses and shear moduli were estimated for the bone-implant interface and in the surrounding bone tissue. These estimated stresses and moduli were not found to be correlated to the dose of radiation.
authors.affiliation: Institute of Anatomy and Cell Biology, Göteborg University, Sweden.
authors.forename: L O
authors.initials: LO
authors.lastname: Ohrnell
authors.forename: R
authors.initials: R
authors.lastname: Brånemark
authors.forename: J
authors.initials: J
authors.lastname: Nyman
authors.forename: P
authors.initials: P
authors.lastname: Nilsson
authors.forename: P
authors.initials: P
authors.lastname: Thomsen
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000473:pathology; D008297:Male; D016348:Osseointegration / Q000502:physiology / Q000528:radiation effects*; D011829:Radiation Dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000601:surgery; D014025:Titanium
chemical_list: D014025:Titanium