The dodo gene family encodes a novel protein involved in signal transduction and protein folding.
Recent studies in yeast, Drosophila and humans have revealed the existence of a highly conserved gene encoding a novel protein, Dodo, comprised of four modules: a WW domain, involved in protein-protein interactions, a peptidyl-prolyl cis-trans isomerase (PPIase) domain belonging to a recently described third family of PPIases involved in protein folding and unfolding, a nuclear localization motif and finally, a long, surface-exposed alpha-helix that is likely to be involved in binding to a cell cycle serine/threonine kinase. The genetic, molecular, biochemical and structural data are reviewed in the context of the potential biological properties of this new protein family.
Maleszka
R
R
Visual Sciences, Research School of Biological Sciences, The Australian National University, Canberra, ACT. maleszka@rsbs-central.anu.edu.au
Lupas
A
A
Hanes
S D
SD
Miklos
G L
GL
D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila / Q000737:chemistry; D029721:Drosophila Proteins; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008938:Mitosis; D008958:Models, Molecular; D008969:Molecular Sequence Data; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017510:Protein Folding; D017433:Protein Structure, Secondary; D015398:Signal Transduction / Q000502:physiology*
D029721:Drosophila Proteins; D005656:Fungal Proteins; D019476:Insect Proteins; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase; C000606849:dod protein, Drosophila