title: Preparation of core particles for aqueous film coating using agitation fluidized bed.
abstract: Core particles used for aqueous film coating were prepared by agitation fluidized bed granulation, and effect of the damping speed on the granule properties of mass median diameter, geometric standard deviation, apparent density, yield, friability and specific surface area were investigated. Film coating by an aqueous acrylic copolymer (Eudragit NE-30D) was carried out using the core particles granulated under three levels of damping speeds, and the drug release properties of each coated product were identified. Relationship between properties of core particles and the drug release properties were clarified and the optimal granulation conditions to make optimal core particles for film coating were determined.
authors.affiliation: Department of Chemical Engineering, Osaka Prefecture University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Watano
authors.forename: K
authors.initials: K
authors.lastname: Ando
authors.forename: K
authors.initials: K
authors.lastname: Miyanami
authors.forename: Y
authors.initials: Y
authors.lastname: Ii
authors.forename: S
authors.initials: S
authors.lastname: Sasatani
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005782:Gels; D010316:Particle Size; D011109:Polymethacrylic Acids; D012996:Solutions; D013499:Surface Properties; D013831:Thiamine / Q000378:metabolism; D014867:Water
chemical_list: D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005782:Gels; D011109:Polymethacrylic Acids; D012996:Solutions; D014867:Water; C038300:methylmethacrylate-methacrylic acid copolymer; D013831:Thiamine