[Pharmaco-toxicologic evaluation of newly synthesized analogs of propafenone].
The basic pharmacological evaluation of five analogues of propafenone was the aim of the present paper. Antiarrhythmic activity of the compounds at 10(-5) mol.kg-1 was established in guinea-pigs using experimental arrhythmias induced by ouabain and aconitine. The beta-adrenolytic efficiency of the compounds was studied in the isolated spontaneously beating guinea-pig atria and expressed as pA2 values against isoprenaline tachycardia. All of the compounds studied were local-anaesthetically active and their indexes of efficiency were 1-5 fold higher in comparison with the standards cocaine and procaine. The acute toxicity of the compounds was within acceptable limits.
Tumová
I
I
Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Racanská
E
E
Csöllei
J
J
Ecker
G
G
Otrusník
R
R
Svec
P
P
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use / Q000633:toxicity; D000779:Anesthetics, Local; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D006168:Guinea Pigs; D007545:Isoproterenol; D011405:Propafenone / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity
D000318:Adrenergic beta-Agonists; D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D011405:Propafenone; D007545:Isoproterenol