Biodistribution of 123I-labeled 4-hydroxytamoxifen derivatives in rats with dimethylbenzanthracene-induced mammary carcinomas.
A 123I-labeled tamoxifen derivative with a high affinity for the antiestrogen-binding site (AEBS) has been prepared. Biodistribution studies in rats showed a good linear correlation between the AEBS contents of tissue in fmol/g and the accumulated amount of radioactivity in percent dose per gram at 24 h.
Kruijer
P S
PS
Radionuclide Centre, Free University, Amsterdam, The Netherlands.
Klok
R P
RP
van den Koedijk
C D
CD
Blankenstein
M A
MA
Voskuil
J H
JH
Verzeijlbergen
J F
JF
Ensing
G J
GJ
Herscheid
J D
JD
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001665:Binding Sites; D002273:Carcinogens; D004965:Estrogen Antagonists / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics*; D005260:Female; D007457:Iodine Radioisotopes / Q000737:chemistry; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002273:Carcinogens; D004965:Estrogen Antagonists; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D013629:Tamoxifen; C016601:afimoxifene; D015127:9,10-Dimethyl-1,2-benzanthracene