[Association of IgA anti-GM1 antibody with antecedent diarrhea in patients with Guillain-Barré syndrome].
IgA has an important role in the gastrointestinal immune system. We investigated IgA anti-GM1 antibodies in Guillain-Barré syndrome (GBS) subsequent to diarrhea. IgA anti-GM1 antibodies were detected more often in GBS patients with a history of antecedent diarrhea than in those without that. Between the GBS patients with a history of prior symptoms of upper respiratory tract infections and those without that, we found no difference of the frequency of increased IgA anti-GM1 antibody titers. Six GBS patients who had antecedent symptoms of upper respiratory tract infections had IgA anti-GM1 antibodies. However, 5 patients of them also had a history of antecedent diarrhea. Our findings show that IgA anti-GM1 antibodies are associated with GBS following diarrhea.
Koga
M
M
Department of Neurology, Dokkyo University School of Medicine.
Yuki
N
N
Hirata
K
K
D001323:Autoantibodies / Q000032:analysis*; D003967:Diarrhea / Q000209:etiology*; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D011129:Polyradiculoneuropathy / Q000150:complications / Q000276:immunology*; D012189:Retrospective Studies
D001323:Autoantibodies; D007070:Immunoglobulin A; D005677:G(M1) Ganglioside