Hypoglycemic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara.
trans-Dehydrocrotonin (t-DCTN), a 19-nor-clerodane diterpene isolated from the bark of Croton cajucara Benth. (Euphorbiaceae) demonstrated a significant hypoglycemic activity in alloxan-induced diabetic rats but not in normal rats, at oral doses of 25 and 50 mg/kg body weight. The drug also effectively lowered the blood sugar levels in glucose fed normal rats. The hypoglycemic effect of t-DCTN was almost comparable to that produced by glibenclamide (2 mg/kg), a clinically useful drug. The results indicate the antihyperglycemic potential of t-DCTN.
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Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Brasil.
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D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D045785:Diterpenes, Clerodane; D005947:Glucose / Q000008:administration & dosage; D005905:Glyburide / Q000494:pharmacology / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D014197:Trees / Q000737:chemistry*
D001786:Blood Glucose; D004224:Diterpenes; D045785:Diterpenes, Clerodane; D000960:Hypolipidemic Agents; C103060:dehydrocrotonin; D005947:Glucose; D005905:Glyburide