title: Effect of temporal resolution on the diagnostic efficacy of contrast-enhanced MRI in the conservatively treated breast.
abstract: OBJECTIVE
  Our goal was to assess the effect of image acquisition rate on the diagnostic efficacy of contrast-enhanced MRI in the conservatively treated breast.
  
  
  METHODS
  Sixty-seven women, treated with breast-conserving surgery and radiotherapy for early-stage breast cancer, were imaged at 1.5 T using a dynamic contrast-enhanced sequence with a temporal resolution of 12 s. Enhancement was recorded over time for the dominant lesion in each patient. Data were subsequently removed to simulate various acquisition rates and the enhancement indexes of benign and malignant lesions were compared.
  
  
  RESULTS
  Seventeen patients had confirmed local recurrence and 50 remained disease-free. There were significant differences in the enhancement indexes of benign and malignant lesions 24-264 s after contrast agent administration. Acquisition rate had a negligible effect upon diagnostic efficacy.
  
  
  CONCLUSIONS
  Two image data sets collected before contrast agent administration and between 1.5 and 3.5 min afterward may be sufficient to differentiate recurrent and benign disease.
authors.affiliation: Department of Medical Physics, University of Hull, England.
authors.forename: D L
authors.initials: DL
authors.lastname: Buckley
authors.forename: S
authors.initials: S
authors.lastname: Mussurakis
authors.forename: A
authors.initials: A
authors.lastname: Horsman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005348:Fibrocystic Breast Disease / Q000175:diagnosis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric