Pivagabine: a novel psychoactive drug.
Pivagabine (4-[(2,2-dimethyl-1-oxopropyl)amino]butanoic acid, CAS 69542-93-4, Tonerg) is a metabolically stable compound with a modulatory effect on some biochemical parameters involved in stress conditions (corticotropin releasing factor, neurosteroids). The compound, tested in several animal models, prevents stress-correlated behavioural deficits. Moreover, pivagabine has a highly significant therapeutic potential in clinical conditions characterized by manifestations of psychological distress due to an inadequate management of stressful events.
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Aziende Chimiche Riunite Angelini Francesco S.p.A. (ACRAF S.p.A.), Medical Department, Rome, Italy.
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D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D006801:Humans; D011619:Psychotropic Drugs / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology
D011619:Psychotropic Drugs; D005680:gamma-Aminobutyric Acid; C038979:pivagabine