Protein acetylation: more than chromatin modification to regulate transcription.
Histone acetyltransferases and deacetylases are involved in the regulation of gene transcription. Recently, tumor suppressor protein p53 has been shown to be a target for transcriptional coactivators that have histone acetyltransferase activity, suggesting acetylation is also involved in the regulation of cell proliferation and tumorigenesis.
Bayle
J H
JH
Department of Pathology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
Crabtree
G R
GR
D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000378:metabolism* / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
D002843:Chromatin; D011506:Proteins