Beta 2-microglobulin amyloidosis presenting as esophageal perforation in a hemodialysis patient.
A 45-year-old male with hypertensive end-stage renal disease and on maintenance hemodialysis for 13 years is reported. He presented with life-threatening hematemesis, secondary to esophageal rupture. Immunohistological staining and electron microscopy examination of the esophageal perforation showed depositions of beta 2-microglobulin (beta 2-M) amyoloid. The unique aspect presented here is the localized esophageal involvement with beta 2-M amyloidosis. This is the first reported patient with esophageal perforation, due to the deposition and infiltration of the lower esophagus with beta 2-M which predisposed to its rupture.
Khan
G A
GA
Woods Memorial Hospital, Etowah, Tenn. 37331, USA.
Lewis
F I
FI
Dasgupta
M
M
D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D004939:Esophageal Perforation / Q000175:diagnosis* / Q000209:etiology; D004947:Esophagus / Q000378:metabolism; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D001613:beta 2-Microglobulin / Q000378:metabolism*
D001613:beta 2-Microglobulin