title: Pregnancy with concomitant chorangioma and placental vascular malformation with mesenchymal hyperplasia.
abstract: We present two pregnancies associated with normal live births and the unusual concomitance of chorangioma and placental vascular malformation with mesenchymal hyperplasia. The enlarged placenta had the characteristic findings of chorangioma, dilated and varicose chorionic vessels and multiple vesicle-like villi containing hyaluronic acid. The vesicle-like villi showed diploid cellular DNA contents. Molecular genetic analysis using the polymerase chain reaction amplification of polymorphic microsatellite markers confirmed genetic identity among the chorangioma, the vesicle-like villi and the fetus. Both pregnancies were complicated by polyhydramnios, pre-term labour and prematurity. One neonate suffered from anaemia and thrombocytopenia. Another neonate suffered from haemangiomatosis. Our cases demonstrate that concomitant chorangioma and placental mesenchymal hyperplasia are genetically identical to the fetus and can coexist with a normal viable fetus. Since haemangiomas, chorangiomas, chorionic vessels and villi mesenchymal cells are all derived from the mesoderm, a combination of fetal haemangiomas, placental vascular malformation, chorangiomas and placental mesenchymal hyperplasia may represent a mixed form of congenital malformation of the mesoderm.
authors.affiliation: Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China.
authors.forename: C P
authors.initials: CP
authors.lastname: Chen
authors.forename: S R
authors.initials: SR
authors.lastname: Chern
authors.forename: T Y
authors.initials: TY
authors.lastname: Wang
authors.forename: Z D
authors.initials: ZD
authors.lastname: Huang
authors.forename: M C
authors.initials: MC
authors.lastname: Huang
authors.forename: C Y
authors.initials: CY
authors.lastname: Chuang
mesh_terms: D000328:Adult; D002196:Capillaries / Q000473:pathology; D002824:Chorionic Villi / Q000098:blood supply; D005260:Female; D006391:Hemangioma / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D008648:Mesoderm / Q000473:pathology; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011256:Pregnancy Outcome