title: Reversible dissociation of sensitivity to dynamic stimuli in Parkinson's disease: is magnocellular function essential to reading motion-defined letters?
abstract: A group of 20 control subjects carried out the following visual tests: Snellen acuity; contrast detection threshold for a temporally unmodulated grating and for a temporally modulated grating; speed threshold for recognising motion-defined dotted letters. Normal limits were defined as 2.5 standard deviations from the respective control means. A patient with Parkinson's disease carried out the tests 12 hr after medication was withheld at a time when symptoms were evident ("off" stage), and after administration of medication when it had taken full effect ("on" stage). Confirming previous reports, contrast detection threshold for the temporally modulated grating was much higher during the "off" stage than during the "on" stage, but contrast detection threshold for the temporally unmodulated grating showed little difference. Speed threshold for recognising motion-defined letters did not, however, fall during the "on" stage. We suggest that magnocellular function is not essential for the recognition of motion-defined form.
authors.affiliation: Department of Ophthalmology, The Toronto Hospital, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Giaschi
authors.forename: A
authors.initials: A
authors.lastname: Lang
authors.forename: D
authors.initials: D
authors.lastname: Regan
mesh_terms: D015350:Contrast Sensitivity; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009039:Motion Perception; D009434:Neural Pathways; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D010469:Perceptual Distortion; D014787:Vision Tests; D014792:Visual Acuity
chemical_list: D007980:Levodopa