title: Analysis of bipolar disorder using affected relatives.
abstract: We have analyzed the GAW10 data from several studies of bipolar affective disorder (BPAD) using the software packages SimIBD and SIMWALK2. SimIBD implements a simulation-based affected-pedigree-member (APM) statistic, called SimAPM, as well as an APM-like statistic, also called SimIBD, that measures identical-by-descent (IBD) sharing. SIMWALK2 uses Markov chain Monte Carlo techniques to compute several IBD-based statistics on the degree of marker-allele clustering among all affected relatives. We have found no strong evidence of linkage to either chromosome 5 or 18. However, we did find that several markers showed p-values less than 0.01 and may deserve further study.
authors.affiliation: Department of Human Genetics, University of Pittsburgh, Pennsylvania 15261, USA.
authors.forename: S
authors.initials: S
authors.lastname: Davis
authors.forename: E
authors.initials: E
authors.lastname: Sobel
authors.forename: M
authors.initials: M
authors.lastname: Marinov
authors.forename: D E
authors.initials: DE
authors.lastname: Weeks
mesh_terms: D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18; D002895:Chromosomes, Human, Pair 5; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D009010:Monte Carlo Method; D010375:Pedigree; D012984:Software
chemical_list: D005819:Genetic Markers