Genetic analysis of simulated oligogenic traits in nuclear and extended pedigrees: summary of GAW10 contributions.
Participants of GAW10 had available simulated data on phenotypic and marker data for 200 replicates of each of two different collections of pedigrees. The simulated phenotype was multivariate and oligogenic, and included a number of complexities. Participants took widely different approaches to analysis. We compare their results to identify analysis approaches and use of the data that had the greatest impact on the conclusions, accuracy of estimates, and power to identify genetic factors.
Wijsman
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EM
Division of Medical Genetics, University of Washington, Seattle 98195-7720, USA.
Amos
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CI
D003198:Computer Simulation; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009679:Nuclear Family; D010375:Pedigree; D010641:Phenotype; D011237:Predictive Value of Tests; D019655:Quantitative Trait, Heritable