[The characteristics of drug distribution in the body under the influence of different types of electrical current].
Rabbit experiments showed that distribution of drugs in the body in intratissue electrophoresis is related to current type. The drugs reach the target organ and are deposited best under the influence of sinusoidal modulated and galvanic currents. The experiments' evidence may serve the basis for differential use of electric currents for intratissue electrophoresis.
Ulashchik
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D000779:Anesthetics, Local / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D002840:Chromates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007478:Iontophoresis / Q000379:methods*; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010710:Phosphates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011343:Procaine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D017670:Sodium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013831:Thiamine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000779:Anesthetics, Local; D002840:Chromates; D010710:Phosphates; D017670:Sodium Compounds; D011343:Procaine; C028982:sodium chromate(VI); C018279:sodium phosphate; D013831:Thiamine