title: A lymphohistiocytic variant of anaplastic large cell lymphoma with demonstration of the t(2;5)(p23;q35) chromosome translocation.
abstract: Cytogenetic investigations were performed in a case of a nodal malignant non-Hodgkin's lymphoma. Histopathological analysis from an involved lymph node as well as from a skin biopsy revealed a lymphohistiocytic variant of CD30-positive anaplastic large cell lymphoma (ALCL). A t(2;5)(p23;q35) chromosome translocation could be observed in all metaphases analysed. This finding was confirmed both by RT-PCR analysis of the NPM/ALK fusion protein and by positive staining with the p80(NPM/ALK) antibody. To the best of our knowledge, this is the first report of a t(2;5) documented by classic cytogenetics in the lymphohistiocytic variant of ALCL.
authors.affiliation: Pathologisches Institut, University of Würzburg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Ott
authors.forename: B C
authors.initials: BC
authors.lastname: Bastian
authors.forename: T
authors.initials: T
authors.lastname: Katzenberger
authors.forename: J F
authors.initials: JF
authors.lastname: Decoteau
authors.forename: J
authors.initials: J
authors.lastname: Kalla
authors.forename: A
authors.initials: A
authors.lastname: Rosenwald
authors.forename: F
authors.initials: F
authors.lastname: Weissinger
authors.forename: M M
authors.initials: MM
authors.lastname: Ott
authors.forename: M E
authors.initials: ME
authors.lastname: Kadin
authors.forename: H K
authors.initials: HK
authors.lastname: Müller-Hermelink
mesh_terms: D000328:Adult; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics*; D014178:Translocation, Genetic