[Value of a genetic evaluation before an intracytoplasmic sperm injection procedure].
Intracytoplasmic sperm injection (ICSI) still needs to be validated as far as safety is concerned. Results concerning foetal karyotypes currently seem to show an increase in sexual chromosomal abnormalities. In view of the heterogeneity of publications concerning genetic tests, it seems necessary to define a protocol with a limited time span, which will allow the extensive collection of data. The analysis of the results will secondarily allow a common procedure to be established. We propose a protocol limited in time, aiming to evaluate the chromosomal status at birth by a systematic karyotype of umbilical cord blood.
Hassan-Alkhadef
C
C
Unité de Médecine de la Reproduction, Fondation-Hôpital Saint-Joseph, Marseille.
Tourame
P
P
Rossin-Amar
B
B
Pascal
A
A
Favre-Eloff
G
G
Pastre-Lucciani
A
A
Berdah
N
N
Bréchard
M P
MP
Boyer
P
P
D000328:Adult; D002869:Chromosome Aberrations / Q000517:prevention & control*; D025063:Chromosome Disorders; D005260:Female; D005817:Genetic Counseling; D005820:Genetic Testing; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D007317:Insemination, Artificial, Homologous / Q000009:adverse effects / Q000379:methods*; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies