title: Caution in the interpretation of MLS.
abstract: We study the statistical properties of the maximum likelihood score (MLS) test. We show that the criteria for reaching conclusions about linkage are not the same for single point analysis as for multipoint, where the maximization is performed over an additional parameter, the position in the marker interval where the MLS is computed. In addition, this test is shown to be very sensitive to errors in allele frequencies and recombination fraction.
authors.affiliation: Laboratory of Medical Statistics, URA CNRS 1323, University of Paris V, France.
authors.forename: S
authors.initials: S
authors.lastname: Eichenbaum-Voline
authors.forename: E
authors.initials: E
authors.lastname: Génin
authors.forename: M C
authors.initials: MC
authors.lastname: Babron
authors.forename: P
authors.initials: P
authors.lastname: Margaritte-Jeannin
authors.forename: B
authors.initials: B
authors.lastname: Prum
authors.forename: F
authors.initials: F
authors.lastname: Clerget-Darpoux
mesh_terms: D000483:Alleles; D003627:Data Interpretation, Statistical; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D016013:Likelihood Functions; D011237:Predictive Value of Tests
chemical_list: D005819:Genetic Markers