MARs mission update.
Genes are organized as chromatin domains and positioned in the nucleus through regions of nuclear matrix association, termed MARs. Although well-studied, the mechanisms regulating expression of the beta-globin locus remain an enigma. Here, we show that certain MAR sequences of the beta-globin locus are conserved and reiterated throughout the genome in association with other genes of the hematopoietic lineage. Further, the density of the MARs within the beta-globin locus and the sharing of these sequences by the various members of this gene cluster suggest that they may provide critical gene regulatory components.
Walter
W R
WR
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Singh
G B
GB
Krawetz
S A
SA
D001483:Base Sequence; D002843:Chromatin / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D016208:Databases, Factual; D005786:Gene Expression Regulation / Q000235:genetics*; D005914:Globins / Q000235:genetics*; D006801:Humans; D019901:Locus Control Region / Q000235:genetics; D008954:Models, Biological; D008969:Molecular Sequence Data; D015530:Nuclear Matrix / Q000737:chemistry*; D012984:Software
D002843:Chromatin; D005914:Globins