title: [Gm and Km allotypes in a Chilean urban population sample].
abstract: BACKGROUND
  The knowledge of the genic structure of a population is of great importance for evolutive studies.
  
  
  OBJECTIVE
  To estimate in a Chilean population sample from the low-middle and low socioeconomic strata of Santiago, haplotypes and allele frequencies for Gm and Km loci.
  
  
  METHODS
  The sample included 460 controls of a case-control study of typhoid fever.
  
  
  RESULTS
  The G1m-G2m-G3m most frequent haplotypes were: za;..;g or 1,17;(-);21 = 0.4493;fn;b or 3;23;5,13 = 0.2522; f-,..;b or 3;(-);5,13 = 0.1389; zax;..;g or 1,2,17;(-);21 = 0.0685; za;..;b or 1,17;(-);5,13 = 0.0454; za;n;g or 1,17;23;21 = 0.0207; f;..;g or 3;(-);21 = 0.0129. The frequencies of Km alleles were 0.2391 and 0.7609 for Km1 and Km3 respectively.
  
  
  CONCLUSIONS
  These frequencies are within those found in Amerindian and Caucasian populations as expected from the origin of the Chilean population. Gm haplotypes did not differ from Hardy-Weinberg equilibrium, while a significant lack of homozygous Km1/km1 was found in Km.
authors.affiliation: Departamento de Biología Celular y Genética, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: M
authors.initials: M
authors.lastname: Arcos-Burgos
authors.forename: C Y
authors.initials: CY
authors.lastname: Valenzuela
authors.forename: P J
authors.initials: PJ
authors.lastname: Herrera
authors.forename: J P
authors.initials: JP
authors.lastname: Pandey
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002677:Chile; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D008297:Male; D010641:Phenotype; D014435:Typhoid Fever / Q000235:genetics*; D014505:Urban Population
chemical_list: D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes