title: Gingival overgrowth and dental alveolar alterations: possible mechanisms of cyclosporin-induced tooth migration. An experimental study in the rat.
abstract: The inter-incisal distance and dimension of the interdental papilla between the mandibular incisors were examined in cyclosporin A (CSA) fed rats over 6 weeks. Rats in the test group received CSA daily in mineral oil by gastric feeding (30 mg/kg body weight); the control group received mineral oil only. The inter-incisal distance and gingival dimensions, including bucco-lingual width and vertical height, were assessed biweekly from alginate impressed stone models. Animals were sacrificed at the end of the study and tissue sections were obtained from the anterior region of the mandible for histopathological evaluation. Both the inter-incisal distance and the dimension of the interdental papilla were significantly greater in CSA-exposed animals compared to control. The significant alteration appeared earlier in the papillary dimensions than that in the interdental distance. Particular histopathological alterations of the soft and hard tissues of the periodontium were observed in CSA-exposed animals. Within limitations of the study, we suggest that the CSA-induced gingival overgrowth may offer an active force contributing to observed tooth movement, however, remarkable alveolar remodeling should be considered as an undetermined factor for the movement.
authors.affiliation: Department of Periodontology, School of Dentistry, National Defense Medical Center, Taipei, Taiwan, ROC.
authors.forename: E
authors.initials: E
authors.lastname: Fu
authors.forename: S
authors.initials: S
authors.lastname: Nieh
authors.forename: U M
authors.initials: UM
authors.lastname: Wikesjö
authors.forename: F G
authors.initials: FG
authors.lastname: Lin
authors.forename: E C
authors.initials: EC
authors.lastname: Shen
mesh_terms: D000464:Alginates; D016301:Alveolar Bone Loss / Q000139:chemically induced* / Q000473:pathology; D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology; D000704:Analysis of Variance; D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects*; D003760:Dental Impression Materials; D004750:Enteral Nutrition; D004846:Epithelial Attachment / Q000187:drug effects / Q000473:pathology; D005881:Gingiva / Q000187:drug effects / Q000473:pathology; D019214:Gingival Overgrowth / Q000139:chemically induced* / Q000473:pathology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007180:Incisor; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000473:pathology; D008899:Mineral Oil; D003765:Models, Dental; D014677:Pharmaceutical Vehicles; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014085:Tooth Migration / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000464:Alginates; D003760:Dental Impression Materials; D007166:Immunosuppressive Agents; D014677:Pharmaceutical Vehicles; D008899:Mineral Oil; D016572:Cyclosporine