title: Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine.
abstract: We have compared the effects of inhaled nitric oxide (iNO) and i.v. nitroglycerin (ivGTN) on the haemodynamic response to phenylephrine-induced hypertension (PEHT) in anaesthetized pigs. PEHT did not change either pulmonary vascular resistance or gas exchange throughout all experiments. Both treatments lowered pulmonary arterial pressure to the same extent (-12.4% iNO; -13.7% ivGTN) and passively via an effect on left atrial pressure (-26.3% iNO; -31.4% ivGTN). Both treatments failed to reverse the decrease in renal blood flow (RBFc) induced by PEHT, but both increased urinary flow (UF) (+128% iNO; +148% ivGTN). IvGTN significantly increased plasma concentrations of nitrite and nitrate during (+22.7% arterial blood; +26.2% venous blood) and beyond the period of infusion (iNO: +6.4% and +4.9%, respectively). In four control pigs (no PEHT), iNO markedly increased RBFc (+109%), glomerular filtration rate (+72.5%) and UF (+68.7%). We conclude that iNO may have direct cardiac and renal effects, probably via intervention of NO carrier forms such as S-nitroso compounds.
authors.affiliation: Anaesthesia Laboratory, Centre Hospitalier de l'Université de Montréal-Pavillon Notre-Dame, Québec, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Troncy
authors.forename: M
authors.initials: M
authors.lastname: Francoeur
authors.forename: I
authors.initials: I
authors.lastname: Salazkin
authors.forename: F
authors.initials: F
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Charbonneau
authors.forename: G
authors.initials: G
authors.lastname: Leclerc
authors.forename: P
authors.initials: P
authors.lastname: Vinay
authors.forename: G
authors.initials: G
authors.lastname: Blaise
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000494:pharmacology*; D009573:Nitrites / Q000097:blood; D005996:Nitroglycerin / Q000494:pharmacology; D010313:Partial Pressure; D010656:Phenylephrine; D012079:Renal Circulation / Q000187:drug effects; D013552:Swine; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D009566:Nitrates; D009573:Nitrites; D014665:Vasodilator Agents; D010656:Phenylephrine; D009569:Nitric Oxide; D005996:Nitroglycerin