[Yersinia pseudotuberculosis sensitivity to fluoroquinolones and the efficacy of pefloxacin in experimental pseudotuberculosis].
The sensitivity of Y. pseudotuberculosis of different origin and plasmid profile to Russian preparations of the ftoroquinolones group (cyprofloxacin, pefloxacin, norfloxacin) was studied. Of the 3 preparations under study, pefloxacin was found to be most active with respect to Y. pseudotuberculosis. The absence of relationship between antibiotic resistance in 4 Y. pseudotuberculosis strains to cyprofloxacin, pefloxacin and norfloxacin and their additional conjugative R-plasmid with molecular weights of 32 and 38 mD was noted. Pefloxacin was shown to give a good sanitation and protective effect in experimental pseudotuberculosis.
Zaĭtseva
E A
EA
Shubin
F N
FN
Besednova
N N
NN
D000818:Animals; D000890:Anti-Infective Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D051379:Mice; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D015366:Pefloxacin / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D012703:Serotyping; D013997:Time Factors; D015011:Yersinia pseudotuberculosis / Q000145:classification / Q000187:drug effects*; D015012:Yersinia pseudotuberculosis Infections / Q000188:drug therapy* / Q000401:mortality
D000890:Anti-Infective Agents; D015366:Pefloxacin; D002939:Ciprofloxacin; D009643:Norfloxacin