title: Ear lobe bilateral necrosis by levamisole-induced occlusive vasculitis in a pediatric patient.
abstract: We describe a bullous-hemorrhagic reaction of the ear lobes in a child with nephrosis after levamisole intake. This drug is used in children as an alternative treatment of corticosteroid-responsive nephrotic syndrome. Histologic evaluation of a lesion revealed necrotizing vasculitis involving mainly the large vessels of the deep plexus. The lesions disappeared 25 days after discontinuation of treatment.
authors.affiliation: Istituto di Scienze Dermatologiche, Clinica pediatrica II, Università degli Studi di Milano, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Menni
authors.forename: G
authors.initials: G
authors.lastname: Pistritto
authors.forename: R
authors.initials: R
authors.lastname: Gianotti
authors.forename: L
authors.initials: L
authors.lastname: Ghio
authors.forename: A
authors.initials: A
authors.lastname: Edefonti
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects* / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000139:chemically induced*; D001706:Biopsy; D002648:Child; D004431:Ear, External / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D007978:Levamisole / Q000009:adverse effects* / Q000627:therapeutic use; D009336:Necrosis; D009404:Nephrotic Syndrome / Q000188:drug therapy; D012867:Skin / Q000098:blood supply; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D014657:Vasculitis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D007978:Levamisole