title: Acinar-islet cell carcinoma presenting as insulinoma.
abstract: A case of acinar-islet cell carcinoma presenting as insulinoma is reported. The patient was a 28-year-old man who presented with two convulsive episodes. Fajans' index [immunoreactive insulin (IRI; microU/ml/ glucose mg/dl)] and Turner's [IRI (microU/ml) x 100/glucose (mg/dl) - 30] index were high (2.8 and 308, respectively), as were serum proinsulin levels (550 pg/ml). Abdominal computed tomography and angiography revealed a highly vascular tumor in the pancreatic tail and several similar tumors in the liver. Histologic features of a biopsy specimen from a hepatic tumor were those of a malignant pancreatic endocrine tumor. Insulin secretion by the liver metastases was confirmed by venous sampling after arterial stimulation with calcium. These findings led us to diagnose malignant insulinoma with liver metastases. Serum levels of alpha-fetoprotein and trypsin were markedly elevated, to 2234 ng/ml (normal < 10) and 22,000 ng/ml (normal < 460) respectively, and these levels continued to rise with further growth of the liver metastases. Immunohistochemically, the metastatic liver tumor specimen was positive for alpha-fetoprotein, alpha 1-antichymotrypsin, chromogranin A, and neuron-specific enolase. These findings of amphicrine features in the tumor were indicative of acinar-islet cell carcinoma that produced alpha-fetoprotein and trypsin in addition to insulin.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimoike
authors.forename: M
authors.initials: M
authors.lastname: Goto
authors.forename: I
authors.initials: I
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Migita
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Yanase
authors.forename: S
authors.initials: S
authors.lastname: Sezai
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Nawata
mesh_terms: D007516:Adenoma, Islet Cell / Q000097:blood / Q000473:pathology*; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018267:Carcinoma, Acinar Cell / Q000097:blood / Q000473:pathology*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007328:Insulin / Q000097:blood; D007340:Insulinoma / Q000097:blood / Q000473:pathology*; D016898:Interferon-alpha / Q000008:administration & dosage; D008297:Male; D010190:Pancreatic Neoplasms / Q000097:blood / Q000473:pathology*; D013311:Streptozocin / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014357:Trypsin / Q000097:blood; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000970:Antineoplastic Agents; D007328:Insulin; D016898:Interferon-alpha; D000509:alpha-Fetoproteins; D013311:Streptozocin; D014357:Trypsin; D005472:Fluorouracil