Considerations in optimizing radiation therapy for non-small cell lung cancer.
Irradiation therapy for lung cancer is mostly restricted to conventional methods. To improve therapeutic ratio, we have combined a treatment planning and a gene therapy approach. Three-dimensional conformal radiotherapy is described as carried out by methods of gene therapy for radiation protection using the manganese-superoxide-dismutase transgene delivered by inhalation gene transfer. These methods may improve therapeutic outcomes in lung cancer.
Greenberger
J S
JS
Department of Radiation Oncology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, PA 15213, USA.
Bahri
S
S
Jett
J
J
Belani
C
C
Kalend
A
A
Epperly
M
M
D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D019583:Dose Fractionation, Radiation; D015316:Genetic Therapy; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D016896:Treatment Outcome