Assessment of insulin resistance in acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy.
With a euglycemic hyperinsulinemic clamp method, whole-body insulin resistance was assessed in 6 cases with acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy. The glucose infusion rate (GIR) correlated well with the plasma IGF-I level but poorly with that of GH. Further improvement in insulin sensitivity occurred 3-4 months after operation without substantial changes in plasma levels of both GH and IGF-I or glycemic control. These results indicate that GH excess can induce insulin resistance in association with plasma IGF-I and also through undefined secondary effect.
Wasada
T
T
Diabetes Center, Tokyo Women's Medical College, Japan.
Aoki
K
K
Sato
A
A
Katsumori
K
K
Muto
K
K
Tomonaga
O
O
Yokoyama
H
H
Iwasaki
N
N
Babazono
T
T
Takahashi
C
C
Iwamoto
Y
Y
Omori
Y
Y
Hizuka
N
N
D000172:Acromegaly / Q000503:physiopathology*; D000236:Adenoma / Q000601:surgery*; D000328:Adult; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000601:surgery*; D013101:Sphenoid Sinus