title: [Intraocular neovascularization].
abstract: To investigate the mechanism of intraocular neovascularization, we studied how vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) are expressed in the ocular tissues under hypoxic conditions. Prior to proliferation of vascular endothelial cells resulting in neovascularization, the retinal tissues such as pericytes, retinal glial cells, ganglion cells, and ciliary epithelium react directly to hypoxia expressing VEGF and/or IL-8 and stimulate endothelial cell proliferation in a paracrine manner. We demonstrated that transcription factor activator protein-1 (AP-1) is activated for expression of VEGF messenger ribonuculeic acid (mRNA) and in a similar way nuclear factor kappa B (NF-kappa B) is activated for expression of IL-8 mRNA. However, hypoxia-induced expression of VEGF and/ or IL-8 is only one aspect of the complicated processes in intraocular neovascularization. We hope that further detailed analysis of the mechanism will make it possible to inhibit and treat clinically intraocular neovascularization in the near future.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka-ken, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Inomata
authors.forename: T
authors.initials: T
authors.lastname: Ishibashi
authors.forename: T
authors.initials: T
authors.lastname: Murata
authors.forename: M
authors.initials: M
authors.lastname: Iwasaki
authors.forename: A
authors.initials: A
authors.lastname: Tahara
authors.forename: K
authors.initials: K
authors.lastname: Hata
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Onishi
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Kubota
authors.forename: Y
authors.initials: Y
authors.lastname: Kawano
authors.forename: S
authors.initials: S
authors.lastname: Sugai
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Okada
authors.forename: S
authors.initials: S
authors.lastname: Ishimoto
authors.forename: K
authors.initials: K
authors.lastname: Fujisawa
authors.forename: T
authors.initials: T
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Shigefuji
authors.forename: I
authors.initials: I
authors.lastname: Tsuji
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
authors.forename: A
authors.initials: A
authors.lastname: Ueno
authors.forename: Y
authors.initials: Y
authors.lastname: Nagatomi
mesh_terms: D000328:Adult; D000818:Animals; D016228:Endothelial Growth Factors / Q000502:physiology; D006801:Humans; D016209:Interleukin-8 / Q000502:physiology; D008222:Lymphokines / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D015861:Retinal Neovascularization / Q000503:physiopathology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D016209:Interleukin-8; D008222:Lymphokines; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors