[Pre-clinical and clinical electrophysiological studies for the prediction of iatrogenic proarrhythmic effect (torsade de pointes)].
The risk of drug-induced torsade de pointes, a potentially lethal ventricular arrhythmia, raises the problem of the early detection of the effects of any new chemical entity (NCE) on ventricular repolarization since prolongation of myocardial repolarization is a major trigger among others (hypokalaemia, bradycardia, congenital abnormalities in cellular ionic channels) for this arrhythmia. During pre-clinical studies, the effects of a range of concentrations (10(-9) M to 10(-4) M) of NCE on the duration of the action potential of Purkinje and left ventricular myocardial cells (guinea-pig and rabbit) have to be measured. If these effects are present, the duration of QT interval on ECG recorded in animal studies (dogs) has to be carefully measured and correlated with plasma concentrations of NCE and/or its metabolite(s). During clinical trials, additional studies have to be performed in order to document QT interval-plasma concentration relationships and the influence of heart rate on QT interval duration. Ambulatory ECG recordings will attest to the safety of the NCE and precautions for use of the drug will be established according to our knowledge of predisposing factors for a proarrhythmic effect. Should there be a notification of a case of torsade de points after a new drug has been launched, urgent consultations with the drug file will be necessary in order to assess which pre-clinical and clinical studies may be needed for a better evaluation of the benefit/risk ratio of the new drug.
Jaillon
P
P
Unité de Pharmacologie Clinique, Hôpital Saint-Antoine, Paris.
Dupuis
B
B
Dahan
R
R
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D006168:Guinea Pigs; D006801:Humans; D007049:Iatrogenic Disease; D008133:Long QT Syndrome / Q000209:etiology*; D008564:Membrane Potentials; D011817:Rabbits; D016171:Torsades de Pointes / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology* / Q000517:prevention & control