title: Effect of amiodarone on the lung shown by polarized light microscopy.
abstract: OBJECTIVE
  To show lipid deposits in the lung of patients treated with amiodarone.
  
  
  METHODS
  Formalin-fixed, unstained frozen sections were used to reveal lipid deposits by means of polarized light. Lung tissues obtained at the postmortem examination of one patient and the surgical biopsy of another were available.
  
  
  RESULTS
  Birefringent lipid deposits were seen in the alveolar lining cells and macrophages, as well as in the walls of arterioles and venules.
  
  
  CONCLUSIONS
  To assess the effect of amiodarone on the lung, polarized light microscopy of unstained, frozen sections is a simple and rapid method.
authors.affiliation: Department of Paediatrics, Addenbrooke's Hospital, Cambridge, United Kingdom.
authors.forename: W
authors.initials: W
authors.lastname: Jacobson
authors.forename: S
authors.initials: S
authors.lastname: Stewart
authors.forename: G A
authors.initials: GA
authors.lastname: Gresham
authors.forename: M J
authors.initials: MJ
authors.lastname: Goddard
mesh_terms: D000638:Amiodarone / Q000494:pharmacology*; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001160:Arterioles / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000737:chemistry; D005629:Frozen Sections; D006801:Humans; D008055:Lipids / Q000032:analysis; D008168:Lung / Q000098:blood supply / Q000737:chemistry / Q000166:cytology / Q000187:drug effects*; D016676:Macrophages, Alveolar / Q000737:chemistry / Q000166:cytology; D008297:Male; D008859:Microscopy, Polarization / Q000379:methods; D008875:Middle Aged; D010740:Phospholipases / Q000037:antagonists & inhibitors; D010758:Phosphorus / Q000032:analysis; D011650:Pulmonary Alveoli / Q000737:chemistry / Q000166:cytology; D011663:Pulmonary Surfactants / Q000032:analysis; D014699:Venules / Q000737:chemistry
chemical_list: D000889:Anti-Arrhythmia Agents; D008055:Lipids; D011663:Pulmonary Surfactants; D010758:Phosphorus; D010740:Phospholipases; D000638:Amiodarone