Antibiotic prophylaxis in patients with urinary retention undergoing transurethral prostatectomy.
OBJECTIVE
The risk of severe infection and complications in connection with transurethral resection of the prostate (TURP) has clearly increased in patients with urinary retention and an indwelling catheter. The aim of this study was to determine whether the antibiotics ciprofloxacin and ceftazidime are equally efficient in preventing infective complications in these patients.


METHODS
An open randomized prospective study was carried out on 72 patients with urinary retention undergoing TURP, to compare of 500 mg of ciprofloxacin (CF) orally twice daily and 1 g of ceftazidime (CT) intravenously twice daily.


RESULTS
The incidence of early complications was 26% in the CF group and 17% in the CT group. All the complications were minor. On removal of the indwelling catheter, a positive urinary culture was detected in 6% of the patients in the CF group and in 3% in the CT group. One month after TURP, a positive urinary culture was detected in 14% of the patients in the CF group and in 18% of the CT group.


CONCLUSIONS
It is concluded that both of the antibiotics used in this trial were equally effective in the prevention of early urinary and other infections and also late complications, in patients with urinary retention undergoing TURP.
Lukkarinen
O
O
Department of Surgery, Oulu University Hospital, Finland.
Hellström
P
P
Leppilahti
M
M
Kontturi
M
M
Tammela
T
T
D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002442:Ceftazidime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011468:Prostatectomy / Q000379:methods*; D016896:Treatment Outcome; D014546:Urinary Catheterization / Q000009:adverse effects; D016055:Urinary Retention / Q000150:complications*; D014552:Urinary Tract Infections / Q000209:etiology / Q000517:prevention & control*
D000890:Anti-Infective Agents; D002511:Cephalosporins; D002939:Ciprofloxacin; D002442:Ceftazidime