Carcinoma of the lung in three brothers and two sisters.
Documentation of familial aggregation of five siblings with lung cancer is presented. Lung cancer was not observed in their parents nor among their children, which is consistent with the hypothesis of recessive inheritance, although strong environmental factors such as tobacco smoking may contribute to the development of lung cancer in such families.
Ghadirian
P
P
Department of Nutrition, Hôtel-Dieu of Montreal, Que., Canada.
Jeanneret
A
A
Perret
C
C
Latreille
J
J
Ayoub
J
J
Sanderson
D
D
D000328:Adult; D000368:Aged; D004781:Environmental Exposure; D005192:Family Health; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012907:Smoking