Investigation of the candidate genes ACTHR and golf for bipolar illness by the transmission/disequilibrium test.
Several versions of the transmission/disequilibrium test (TDT) were applied to the two candidate genes ACTHR and Golf for bipolar illness. Analyses were carried out separately for paternal and maternal transmission. Evidence for linkage and association was found for ACTHR for paternal transmission in support of a parent-of-origin effect. Possible evidence for segregation distortion was found for one of the two markers for Golf for maternal transmission.
Bickeböller
H
H
Institute for Medical Statistics and Epidemiology, Technische Universität München, Germany.
Kistler
M
M
Scholz
M
M
D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005819:Genetic Markers; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009679:Nuclear Family; D010641:Phenotype
D005819:Genetic Markers