title: Ascending myelitis in association with herpes simplex virus. A case report.
abstract: A 50 year old man developed ascending necrotizing myelitis without any associated disease. After admission due to gait disturbance, the symptoms progressed rapidly and quickly. Neurological disturbance had progressed to an incomplete paraplesia below C 4 level; incontinence and drowsiness developed. Herpes Simplex viral myelitis was suspected through virological tests, which showed higher specific HSV antibody values of HSV-1 IgG of 640-fold in serum. Myelin basic protein (MBP) in the cerebrospinal fluid (CSF) registered 24.3 ng/ml. When he was treated with Acyclovir for 17 days, his general and neurological status improved significantly. Virological examinations showed 50-fold HSV-1 IgG in serum, and MBP in the CSF was 3.3 ng/ml. The MBP measurement and virological tests of the CSF and serum prove extremely important in diagnosing an ascending myelitis of unknown cause.
authors.affiliation: Department of Orthopaedic Surgery, Nippon Medical School.
authors.forename: M
authors.initials: M
authors.lastname: Miyamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Shirai
authors.forename: Y
authors.initials: Y
authors.lastname: Genbun
authors.forename: H
authors.initials: H
authors.lastname: Maruyama
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D006561:Herpes Simplex; D017405:Herpes Simplex Virus Protein Vmw65 / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid; D009187:Myelitis / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology*; D018139:Simplexvirus / Q000302:isolation & purification
chemical_list: D000998:Antiviral Agents; D017405:Herpes Simplex Virus Protein Vmw65; D004676:Myelin Basic Protein; D000212:Acyclovir