title: Preparation of (R)-N-methylsalsolinol via reversed-phase high-performance liquid chromatography using beta-cyclodextrin as a mobile-phase additive.
abstract: A new preparation method was devised using beta-cyclodextrin as a mobile-phase additive in a reversed-phase high-performance liquid chromatography system. Preparative separation of the biologically active (R)-enantiomer was achieved from racemic N-methylsalsolinol. Beta-cyclodextrin was removed completely in good yield by acid extraction and solid-phase extraction. By a slight modification, this method will be applicable to the isolation of various types of biologically important enantiomers.
authors.affiliation: Department of Applied Chemistry, Nagoya Institute of Technology, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Minami
authors.forename: Y
authors.initials: Y
authors.lastname: Deng
authors.forename: F
authors.initials: F
authors.lastname: Urano
authors.forename: T
authors.initials: T
authors.lastname: Kaiya
authors.forename: K
authors.initials: K
authors.lastname: Kohda
authors.forename: M
authors.initials: M
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Naoi
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002942:Circular Dichroism; D003505:Cyclodextrins / Q000737:chemistry*; D012490:Salsoline Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines
chemical_list: D003505:Cyclodextrins; D012490:Salsoline Alkaloids; D044005:Tetrahydroisoquinolines; C032837:salsoline