title: The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes.
abstract: The chemosensory pathway of bacterial chemotaxis has become a paradigm for the two-component superfamily of receptor-regulated phosphorylation pathways. This simple pathway illustrates many of the fundamental principles and unanswered questions in the field of signaling biology. A molecular description of pathway function has progressed rapidly because it is accessible to diverse structural, biochemical, and genetic approaches. As a result, structures are emerging for most of the pathway elements, biochemical studies are elucidating the mechanisms of key signaling events, and genetic methods are revealing the intermolecular interactions that transmit information between components. Recent advances include (a) the first molecular picture of a conformational transmembrane signal in a cell surface receptor, (b) four new structures of kinase domains and adaptation enzymes, and (c) significant new insights into the mechanisms of receptor-mediated kinase regulation, receptor adaptation, and the phospho-activation of signaling proteins. Overall, the chemosensory pathway and the propulsion system it regulates provide an ideal system in which to probe molecular principles underlying complex cellular signaling and behavior.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215, USA. falke@colorado.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Falke
authors.forename: R B
authors.initials: RB
authors.lastname: Bass
authors.forename: S L
authors.initials: SL
authors.lastname: Butler
authors.forename: S A
authors.initials: SA
authors.lastname: Chervitz
authors.forename: M A
authors.initials: MA
authors.lastname: Danielson
mesh_terms: D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins; D002628:Chemoreceptor Cells / Q000502:physiology; D002633:Chemotaxis; D000071677:Histidine Kinase; D011494:Protein Kinases; D011956:Receptors, Cell Surface; D015398:Signal Transduction / Q000502:physiology*; D012995:Solubility
chemical_list: D001426:Bacterial Proteins; D011956:Receptors, Cell Surface; D011494:Protein Kinases; D000071677:Histidine Kinase