The cortical neuropeptide, cortistatin-14, impairs post-training memory processing.
Cortistatin-14, a neuropeptide, is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin-14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistatin-14 would impair retention, saline or cortistatin-14 were injected intracerebroventricularly after footshock avoidance training in CD-1 mice. After 1 week, training was resumed to determine the effect of cortistatin-14 on retention. Cortistatin-14 was found to impair retention relative to the control group at doses of 0.5-5.0 micrograms.
Flood
J F
JF
Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO 63106, USA. jff31545@aol.com
Uezu
K
K
Morley
J E
JE
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004597:Electroshock; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology*
D009479:Neuropeptides; C099323:cortistatin