The "possible triangle" test for extreme discordant sib pairs.
For the analysis of quantitative traits in nuclear families, extreme discordant sib pairs proved to be more powerful than unselected sib pairs. Here, we present a test that makes use of selected pairs and, in addition, restricts the parameters of the identical-by-descent distribution analogously to the "possible triangle" for affected sib pairs. In the Problem 2A data, extreme discordant sib pairs are selected. The analysis allowed the detection of most simulated major genes.
Kruse
R
R
Institute for Medical Statistics, University of Bonn, Germany.
Seuchter
S A
SA
Baur
M P
MP
Knapp
M
M
D002874:Chromosome Mapping; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D016013:Likelihood Functions; D016555:Matched-Pair Analysis; D009679:Nuclear Family; D019655:Quantitative Trait, Heritable
D005819:Genetic Markers