Effects of streptozotocin-induced diabetes on place conditioning action of cocaine in mice.
The effect of diabetes on the cocaine-induced place conditioning in mice was examined. In non-diabetic mice, cocaine, at dose ranges from 1 to 30 mg/kg, s.c. caused a dose-related preference for the drug-associated place, and significant place conditioning was observed at 10 and 30 mg/kg. In diabetic mice, cocaine at a dose of 10 mg/kg, s.c. did not produce a significant place preference, but a significant place conditioning was observed at 30 mg/kg. These results suggest that the reinforcing property of cocaine in diabetic mice was less than that in non-diabetic mice.
Kamei
J
J
Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Science, Hoshi University, Tokyo, Japan.
Ohsawa
M
M
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000523:psychology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007279:Injections, Subcutaneous; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D012054:Reinforcement, Psychology
D018765:Dopamine Uptake Inhibitors; D008694:Methamphetamine; D003042:Cocaine