Risk factors for ischemic stroke in a Russian community: a population-based case-control study.
OBJECTIVE
This study was conducted to determine the risk factors for ischemic stroke in a defined Russian population.


METHODS
Our data are based on a population-based case-control study of 237 patients with first-ever ischemic stroke and 237 age- and sex-matched controls. Logistic regression methods for matched pairs were used to estimate the relative risk for the variables studied.


RESULTS
In a multivariate analysis, hypertension, left ventricular hypertrophy on electrocardiography, ischemic heart disease, mitral valve disease, current cigarette smoking, and high body mass index were significant and independent risk factors for ischemic stroke in this Russian community.


CONCLUSIONS
The significant risk factors for ischemic stroke in Novosibirsk are similar to those from other populations and cohorts. This study, the first of stroke risk factors in Russia, has implications for clinical practice and the planning of stroke prevention in the population.
Feigin
V L
VL
Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA.
Wiebers
D O
DO
Nikitin
Y P
YP
O'Fallon
W M
WM
Whisnant
J P
JP
D000368:Aged; D000787:Angina Pectoris / Q000453:epidemiology; D001145:Arrhythmias, Cardiac / Q000453:epidemiology; D015992:Body Mass Index; D002545:Brain Ischemia / Q000453:epidemiology* / Q000517:prevention & control; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000517:prevention & control; D015331:Cohort Studies; D004562:Electrocardiography / Q000706:statistics & numerical data; D005260:Female; D006285:Health Planning; D006333:Heart Failure / Q000453:epidemiology; D006349:Heart Valve Diseases / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology; D017202:Myocardial Ischemia / Q000453:epidemiology; D011159:Population Surveillance; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology