title: A rapid brain metabolic change in infants detected by fMRI.
abstract: To determine developmental changes of activity-related metabolism in human visual cortex, we performed functional magnetic resonance imaging (fMRI) from the neonatal period. A rapid metabolic changing pattern accompanying normal human brain maturation was revealed by fMRI with photic stimulation. Infants older than 8 weeks of age showed a stimulus-related signal decrease in the visual cortex, whereas younger neonates showed a signal increase. This inversion of response in infants suggests a change in oxygen consumption during neuronal activation, which is related to rapid synapse formation and accompanying increased metabolism. fMRI can detect dynamic metabolic changes during the brain maturation, and provides a new clue in the detection of abnormal brain development or CNS plasticity.
authors.affiliation: Department of Radiology, Fukui Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: N
authors.initials: N
authors.lastname: Sadato
authors.forename: Y
authors.initials: Y
authors.lastname: Konishi
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Yonekura
authors.forename: Y
authors.initials: Y
authors.lastname: Ishii
mesh_terms: D000375:Aging / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male