Temporal control of IgH gene expression in developing B cells by the 3' locus control region.
The suggested roles of the downstream 3' regions acting as a Locus Control Region (LCR), have allowed comparisons to be made between the regulation of the IgH locus with other model systems whose gene expression is governed by LCR activity. Here we summarize the importance of the IgH 3'LCR and its putative functional role in IgH gene expression and compare it with the 5'LCR regulatory region of the human beta-globin locus.
Pettersson
S
S
Department of Biosciences, Karolinska Institute, Huddinge, Sweden. sven.pettersson@cbt.ki.se
Arulampalam
V
V
Neurath
M
M
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D002454:Cell Differentiation; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000276:immunology; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D051863:Host Cell Factor C1; D006801:Humans; D017578:Immunoglobulin Class Switching; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007438:Introns; D051379:Mice; D050811:Octamer Transcription Factor-1; D050813:Octamer Transcription Factor-2; D011401:Promoter Regions, Genetic; D011995:Recombination, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000276:immunology
D004268:DNA-Binding Proteins; C497692:HCFC1 protein, human; C497693:Hcfc1 protein, mouse; D051863:Host Cell Factor C1; D007143:Immunoglobulin Heavy Chains; D050811:Octamer Transcription Factor-1; D050813:Octamer Transcription Factor-2; C494165:POU2F1 protein, human; C058435:POU2F2 protein, human; C494166:Pou2f1 protein, mouse; C489206:Pou2f2 protein, mouse; D014157:Transcription Factors