A population-based family study (II): Segregation analysis.
We used segregation analysis to investigate the genetic etiology of the disease in Problem 2A. Under the assumption of a dominant major gene, our analysis suggests a major gene with relative risk of 58 and an allele frequency of 0.013. Under an additive gene assumption, it appears that there may be two genes with relative risks of 39 and 17 and allele frequencies of 0.015 and 0.075, respectively.
Zhao
L P
LP
Quantitative Genetic Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
Quiaoit
F
F
Hsu
L
L
Davidov
O
O
Holte
S
S
D016022:Case-Control Studies; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008540:Meiosis / Q000235:genetics*; D008957:Models, Genetic; D009679:Nuclear Family