[Cholestasis syndrome in newborn infants: value of gallbladder ultrasound].
OBJECTIVE
Evaluation of sonography in the assessment of changes of the biliary system of newborn infants receiving total parenteral nutrition.


METHODS
In 20 premature infants on mechanical ventilation, the influence of two different amino acid solutions (Vaminolac, Paedamin) in the development of neonatal cholestasis was analysed. The patients were randomised in two groups. Group 1 (n = 11) received Paedamin, group 2 (n = 9) received Vaminolac.


RESULTS
There was no statistically significant influence of the amino acid solution on the development of cholestasis. However, the majority of the children with cholestasis (8 of 11) presented with sepsis.


CONCLUSIONS
Bacterial infections seem to be closely related to the development of cholestasis. Sludge formation within the bile ducts represents a sensitive sonographic parameter for the diagnosis and follow-up of cholestasis secondary to total parenteral nutrition.
Wandl-Vergesslich
K
K
Abteilung Allgemeine Pädiatrie, Universitätsklinik für Kinder und Jugendheilkunde Wien.
Strasser
R
R
Gulesserian
T
T
Youssefzadeh
S
S
Radner
M
M
Weninger
M
M
D000596:Amino Acids / Q000008:administration & dosage; D000601:Amino Acids, Essential / Q000008:administration & dosage; D001646:Bile / Q000000981:diagnostic imaging; D001651:Cholestasis, Extrahepatic / Q000000981:diagnostic imaging* / Q000209:etiology; D004573:Electrolytes; D005260:Female; D005526:Food, Formulated; D005704:Gallbladder / Q000000981:diagnostic imaging*; D005947:Glucose; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D015931:Intensive Care, Neonatal; D007567:Jaundice, Neonatal / Q000000981:diagnostic imaging* / Q000209:etiology; D008297:Male; D057947:Parenteral Nutrition Solutions; D010289:Parenteral Nutrition, Total; D011247:Pregnancy; D012996:Solutions; D014463:Ultrasonography
D000596:Amino Acids; D000601:Amino Acids, Essential; D004573:Electrolytes; D057947:Parenteral Nutrition Solutions; D012996:Solutions; C545824:amino-acid, glucose, and electrolyte solution; D005947:Glucose