The role of kinins in the antihypertensive and cardioprotective effects of ACE inhibitors.
Kinins are highly potent vasoactive peptides. They reduce blood pressure by vasodilation and are cardio- and vasoprotective. ACE inhibitors potentiate the actions of endogenous kinins by about 50-fold. Kinins are involved in the blood pressure-lowering effects of ACE inhibitors in all forms of hypertension associated with stimulation of the renin-angiotensin system. In addition, kinins play an important role in the metabolic, and cardio- and vasoprotective effects of ACE inhibitors.
Bönner
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Clinic Lazariterhof, Centre for Medical Rehabilitation, Bad Krozingen, Germany.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D006801:Humans; D007705:Kinins / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000187:drug effects; D015427:Reperfusion Injury / Q000517:prevention & control; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D001786:Blood Glucose; D007705:Kinins; D001920:Bradykinin