title: Early irreversible osteonecrosis versus transient lesions of the femoral condyles: prognostic value of subchondral bone and marrow changes on MR imaging.
abstract: OBJECTIVE
  The purpose of this study was to determine the MR imaging features that enable differentiation between early irreversible osteonecrosis and transient lesions in nontraumatic lesions of the femoral condyle having the "bone marrow edema" pattern on MR imaging.
  
  
  METHODS
  We reviewed 23 nontraumatic painful lesions of the femoral condyle in 23 patients (12 men and 11 women; mean age, 62 years). All patients had undergone radiography of the knee with findings that were normal or inconclusive. Also, all patients underwent MR imaging that revealed the bone marrow edema pattern in a condyle. Lesions observed after trauma, surgery, or glucocorticoid medication, or with epiphyseal collapse or degenerative joint disease on initial plain radiographs, were excluded from this study. Of the 23 lesions, 14 showed complete resolution (and were designated as transient epiphyseal lesions). The remaining nine lesions were irreversible and, on follow-up radiographic and MR imaging studies, evolved to collapsed osteonecrosis (and were designated as early osteonecrosis). The presence and size of the subchondral features observed by two radiologists on initial MR studies were compared for both irreversible and transient epiphyseal lesions.
  
  
  RESULTS
  Initial MR imaging characteristics indicative of an early irreversible osteonecrosis included a subchondral area of low signal intensity on T2-weighted images with a thickness of more than 4 mm (sensitivity, 100% and 100%; specificity, 82% and 74% for the two observers) or a length of more than 14 mm (sensitivity, 89% and 88%; specificity, 93% and 87% for the two observers), focal epiphyseal contour depressions, and lines of low signal intensity located deep in the affected condyle. The extent of edema was similar for both transient epiphyseal lesions and early osteonecrosis.
  
  
  CONCLUSIONS
  Careful assessment of MR imaging changes occurring in the subchondral area can enable confident differentiation between transient epiphyseal lesions and early irreversible osteonecrosis of the femoral condyle.
authors.affiliation: Department of Radiology, St Luc University Hospital, University of Louvain, Brussels, Belgium.
authors.forename: F E
authors.initials: FE
authors.lastname: Lecouvet
authors.forename: B C
authors.initials: BC
authors.lastname: van de Berg
authors.forename: B E
authors.initials: BE
authors.lastname: Maldague
authors.forename: C J
authors.initials: CJ
authors.lastname: Lebon
authors.forename: J
authors.initials: J
authors.lastname: Jamart
authors.forename: M
authors.initials: M
authors.lastname: Saleh
authors.forename: H
authors.initials: H
authors.lastname: Noël
authors.forename: J
authors.initials: J
authors.lastname: Malghem
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D001855:Bone Marrow Diseases / Q000175:diagnosis; D003937:Diagnosis, Differential; D004487:Edema / Q000175:diagnosis; D005260:Female; D005269:Femur / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000175:diagnosis*; D011379:Prognosis; D012680:Sensitivity and Specificity