Synthesis of [18F]fluoroetanidazole: a potential new tracer for imaging hypoxia.
A method has been developed for the synthesis of [18F]fluoroetanidazole, a potential tracer for imaging hypoxia with positron emission tomography. The compound is prepared by an active ester coupling reaction between the 2,3,5,6-tetrafluorophenyl ester of 2-nitroimidazole acetic acid and [18F]fluoroethylamine. [18F]Fluoroethylamine is prepared from N-[2-(toluene-4-sulfonyloxy)-ethyl]-phthalimide and [18F]fluoride and purified by distillation. The overall reaction takes about 90 min and gives a yield, uncorrected, of about 25%. Purification on a reversed-phase column is straightforward.
Tewson
T J
TJ
Department of Radiology, University of Washington, Seattle 98195-6004, USA. ttewson@u.washington.edu
D017341:Etanidazole / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D000860:Hypoxia / Q000000981:diagnostic imaging; D007553:Isotope Labeling; D011838:Radiation-Sensitizing Agents / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D011838:Radiation-Sensitizing Agents; D019275:Radiopharmaceuticals; C110581:fluoroetanidazole; D017341:Etanidazole