Carcinogenesis in accessory sex organs of rats induced by 3,2'-dimethyl-4-aminobiphenyl: response to androgen deprivation.
It is generally accepted that early human prostate cancers reveal higher androgen dependency than do advanced ones. In the present study, we examined whether the animal model of prostate cancer has already lost androgen dependency at the early stages of carcinogenesis. At experimental week 46, androgen deprivation was induced in rats and the incidences of atypical hyperplasia and cancer were examined in the ventral, dorsolateral prostate, coagulating glands, and seminal vesicles. Androgen deprivation significantly lowered the incidence of atypical hyperplasia in all four organs. As for the incidence of cancer, no significant differences were observed in the coagulating glands and seminal vesicles. Regarding atypical hyperplasia, androgen deprivation significantly decreased the proliferative cell nuclear antigen labeling index in the coagulating gland and seminal vesicles. The presence of cancer was also decreased in the coagulating gland but not in the seminal vesicles. With control group specimens, more intense staining of androgen receptor was observed in atypical hyperplasias than in cancers. Compared with the atypical hyperplasias, the cancers revealed low androgen dependency at the early stages of carcinogenesis. The cancers in the seminal vesicles also revealed higher androgen independency than did those in the coagulating gland.
Tamura
Y
Y
Department of Urology, Gunma Cancer Center, Ohta, Japan.
Ono
Y
Y
Suzuki
T
T
Suzuki
K
K
Takezawa
Y
Y
Mashimo
T
T
Fukabori
Y
Y
Yuasa
H
H
Imai
K
K
Yamanaka
H
H
Suzuki
K
K
D000611:Aminobiphenyl Compounds; D000726:Androgen Antagonists / Q000494:pharmacology*; D000728:Androgens / Q000172:deficiency* / Q000502:physiology; D000818:Animals; D002273:Carcinogens; D002455:Cell Division / Q000502:physiology; D003043:Cocarcinogenesis; D006965:Hyperplasia; D007150:Immunohistochemistry; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000139:chemically induced / Q000209:etiology* / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D011470:Prostatic Hyperplasia / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D011944:Receptors, Androgen / Q000502:physiology; D012669:Seminal Vesicles / Q000187:drug effects* / Q000473:pathology*
D000611:Aminobiphenyl Compounds; D000726:Androgen Antagonists; D000728:Androgens; D002273:Carcinogens; D018809:Proliferating Cell Nuclear Antigen; D011944:Receptors, Androgen; C001042:2',3-dimethyl-4-aminobiphenyl