title: Intravesical electromotive drug administration for the treatment of non-infectious chronic cystitis.
abstract: Seventeen patients with non-infectious chronic cystitis (NICC) (9 with interstitial cystitis, 6 patients with radiation cystitis, 1 with chemocystitis and 1 with lupoid cystitis) were treated with electromotive administration of intravesical lidocaine and dexamethasone followed by hydrodistension of the bladder. Complete resolution of symptoms for an average of 7.5 months was observed in 11 patients (65%), partial improvement in 4 (23.5%). In this series no complications occurred. Electromotive drug administration (EMDA) and cystodistension were well tolerated by all patients. The treatment was performed on an outpatient basis, thus reducing therapeutic costs. The results presented demonstrate that the combination of EMDA and bladder hydrodistension is an effective first-line treatment for NICC patients.
authors.affiliation: Department of Urology and Ludwig-Boltzmann-Institute for Urology and Andrology, Municipal Hospital Lainz, Vienna, Austria.
authors.forename: C R
authors.initials: CR
authors.lastname: Riedl
authors.forename: M
authors.initials: M
authors.lastname: Knoll
authors.forename: E
authors.initials: E
authors.lastname: Plas
authors.forename: R L
authors.initials: RL
authors.lastname: Stephen
authors.forename: H
authors.initials: H
authors.lastname: Pflüger
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D003556:Cystitis / Q000188:drug therapy / Q000628:therapy*; D018856:Cystitis, Interstitial / Q000188:drug therapy; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011312:Pressure
chemical_list: D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D008012:Lidocaine