Selected leukodystrophies.
The clinicopathologic profiles of the major leukodystrophies (adreno-leukodystrophy, metachromatic leukodystrophy, globoid cell leukodystrophy or Krabbe's disease, Pelizaeus-Merzbacher disease, and spongy degeneration of infancy or Canavan's disease) are reviewed. Particular attention is paid to distinctive imaging characteristics, molecular advances, pathogeneses, and potential therapies.
Powers
J M
JM
Department of Pathology and Laboratory Medicine, University of Rochester Medicine Center, NY 14642, USA.
Rubio
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D000293:Adolescent; D000326:Adrenoleukodystrophy / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D017825:Canavan Disease / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007965:Leukodystrophy, Globoid Cell / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D007966:Leukodystrophy, Metachromatic / Q000473:pathology / Q000503:physiopathology / Q000628:therapy