Axon guidance: crossing the midline.
Neurons that connect the two sides of the nervous system project their axons across the midline. New studies provide evidence for a conserved gatekeeping mechanism that controls this midline crossing.
Thomas
J B
JB
Molecular Neurobiology Laboratory, The Salk Institute, P.O. Box 85800, San Diego, California 92186, USA.
D000818:Animals; D001369:Axons / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000196:embryology*; D002490:Central Nervous System / Q000196:embryology* / Q000648:ultrastructure; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics / Q000648:ultrastructure; D004625:Embryo, Nonmammalian / Q000648:ultrastructure; D047108:Embryonic Development; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D008959:Models, Neurological; D009024:Morphogenesis; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D051381:Rats; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity; D000097905:Roundabout Proteins
D029721:Drosophila Proteins; D015801:Helminth Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; C110665:comm protein, Drosophila