title: Multiple pulmonary nodules after recovery from chickenpox in a patient with chronic lymphocytic leukaemia.
abstract: A 61-year-old woman with chronic lymphocytic leukaemia (CLL) was found to have multiple pulmonary nodules on an annual chest radiograph 4 months after recovery from chickenpox. To exclude the metastatic carcinoma, an open lung biopsy was performed. Histological examination disclosed isolated necrotic nodules surrounded by some lymphocytes and a few giant cells. These histological findings were compatible with healed varicella pneumonia and the DNA of varicella-zoster virus (VZV) was detected by polymerase chain reaction (PCR) method. We report a case of asymptomatic pulmonary involvement of VZV infection in a patient with CLL.
authors.affiliation: Department of Internal Medicine, Shiokawa Hospital, Yamanashi-ken, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyashita
authors.forename: H
authors.initials: H
authors.lastname: Koike
authors.forename: A
authors.initials: A
authors.lastname: Misawa
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Yasutomi
authors.forename: N
authors.initials: N
authors.lastname: Kanai
authors.forename: T
authors.initials: T
authors.lastname: Kagami
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D002644:Chickenpox / Q000150:complications* / Q000276:immunology; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D016133:Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral