[Evaluation of the usefulness of dressings made from chitosan and lyophilized human placenta on wound healing].
The goal of this study is evaluation in experimental and clinical circumstances of biological dressings obtained form lyophilized human placenta and chitosan. The therapeutic specificities of human placenta where confirmed in the course many years' observation in The Department of Surgery of the Digestive Tract. The reservation arose only because of inconvenience in using placenta fragile after lyophilization. The product was obtained in the course of studies which were performed in common with The Chemical Fibres Institute in Lódź. This product (which was a combination of placenta and chitosan) was free of defects considering defects of lyophilized placenta. The experimental part of study was performed on 50 female rats of Wistar strain. It was compared healing of wound 2 cm2 area provided with tested dressing and the other controlled wound. The result was evaluated on the ground of postoperative survival and the macroscopic and microscopic evaluation. In the clinical part of the study the experimental model was made by wounds provided by sutures passed by all layers on special "small drains" which under drains make bedsores placed symmetrically on both sides of incision line. The evaluation was performed randomly putting on one of these sides of tested dressing. There was evaluated the speed of demarcation, growth of granulation tissue and epithelialization. The evaluation was compared with standard dressing. Combination of therapeutic specificities of lyophilized human placenta with proper mechanical specificities of chitosan made possible to obtain comfortable and efficient dressing. In the clinical part of the study on the ground of macroscopic evaluation it was found that the process of the healing in tested group becomes shorter of about 48 hours.
Drenda
P
P
Kliniki Chirurgii Przewodu Pokarmowego Slaskiej Akademii Medycznej w Katowicach.
Lampe
P
P
Górka
Z
Z
Bursig
H
H
Dylag
S
S
D000368:Aged; D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials; D001684:Biological Dressings; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology; D048271:Chitosan; D005260:Female; D005612:Freeze Drying; D006801:Humans; D008875:Middle Aged; D010920:Placenta; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000628:therapy
D001672:Biocompatible Materials; D002686:Chitin; D048271:Chitosan