title: [Combined lytic and heart surgical therapy of in open foramen ovale incarcerated giant thrombus with pulmonary and cerebral embolization].
abstract: A case of phlebothrombosis with recurrent pulmonary and cerebral embolism is presented which occurred in a 42 year old patient two weeks after treatment of a traumatic crural fracture despite of prophylaxis with low molecular heparin. By means of transthoracic echocardiography a large intracardiac thrombus was detected, entrapped in an patent foramen ovale (PFO) and prolapsing through both atrioventricular valves into both ventricles. This was found after systemic thrombolysis with rtPA had been performed because of fulminant pulmonary embolism. Subsequently the intracardiac thrombus was surgically removed and the PFO closed. The importance of an PFO for paradoxical embolism is discussed as well as the various therapeutical paths to treat an "embolus-in-transit" (cardiac surgery, thrombolytic therapy or anti-coagulation).
authors.affiliation: I. Medizinische Abteilung, Städtisches Krankenhaus, München-Bogenhausen.
authors.forename: P
authors.initials: P
authors.lastname: Oldenbüttel
authors.forename: D H
authors.initials: DH
authors.lastname: Antoni
authors.forename: H J
authors.initials: HJ
authors.lastname: Krieg
authors.forename: M
authors.initials: M
authors.lastname: Engel
authors.forename: K
authors.initials: K
authors.lastname: Wencke
authors.forename: W
authors.initials: W
authors.lastname: Delius
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005594:Fracture Fixation, Intramedullary; D018460:Fractures, Comminuted / Q000601:surgery*; D006344:Heart Septal Defects, Atrial / Q000601:surgery*; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000601:surgery*; D011655:Pulmonary Embolism / Q000601:surgery*; D017131:Thrombectomy; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000601:surgery*; D013978:Tibial Fractures / Q000601:surgery*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage
chemical_list: D000925:Anticoagulants; D010959:Tissue Plasminogen Activator