title: Antioxidants and AP-1 activation: a brief overview.
abstract: Activity of the transcription factor AP-1 is controlled by different MAPK cascades that regulate the different AP-1 components at the transcriptional and posttranscriptional level. Recently, AP-1 has been shown to behave as a redox-sensitive transcription factor that can be induced under both pro-oxidative and antioxidative conditions. In this overview we summarize the signaling pathways that converge on the activation of AP-1 and the components of these pathways that have been shown to be targets of antioxidants. The activation of AP-1 by antioxidants may account for the expression of a number of genes that mediate important functions under physiological conditions.
authors.affiliation: Servicio de Inmunología, Hospital de la Princesa, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Gomez del Arco
authors.forename: S
authors.initials: S
authors.lastname: Martínez-Martínez
authors.forename: V
authors.initials: V
authors.lastname: Calvo
authors.forename: A L
authors.initials: AL
authors.lastname: Armesilla
authors.forename: J M
authors.initials: JM
authors.lastname: Redondo
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D015398:Signal Transduction; D018808:Transcription Factor AP-1 / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D018808:Transcription Factor AP-1