Mutagenicity of 4-nitroquinoline n-oxide after its complexation with copper (II) 2-chlorophenoxyacetate.
Using the AMes test with Salmonella typhimurium strains TA97, TA100 and TA102, it was found that the mutagenicity of 4-nitroquinoline-N-oxide was much lower than that of the tetrakis[mu-2-chlorophenoxyacetato(1-)-O,O[bis(4-nitro-quinoline- N-oxide-O)dicopper(II) complex.
Blahová
M
M
Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.
Lahitová
N
N
Sokolík
J
J
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects*
D009153:Mutagens; D009942:Organometallic Compounds; C111018:tetrakis(mu-2-chlorophenoxyacetato(1-)-O,O')bis(4-nitroquinoline N-oxide-O)dicopper(II); D015112:4-Nitroquinoline-1-oxide