Role of carbohydrate type on diet selection in neuropeptide Y-stimulated rats.
We tested whether carbohydrate source (corn starch, sucrose, Polycose) influences the choice between a high-fat and high-carbohydrate diet in spontaneously feeding rats and in rats stimulated to eat by neuropeptide Y (NPY) administration or food deprivation. Rats were tested under three diet options: 1) a high-fat diet versus a high-corn starch diet; 2) a high-fat diet versus a high-sucrose diet, and 3) a high-fat diet versus a high-Polycose diet. During daily and stimulated feeding rats ate more of the high-carbohydrate diet than the fat diet when the source of carbohydrate was sucrose or Polycose; however, when corn starch was provided as the carbohydrate source rats ate more of the high-fat diet. Food-deprived rats increased intake of both the high-fat and the high-carbohydrate diets, with the proportion of energy ingested from each of the diets resembling that noted during 3 days of spontaneous feeding. NPY-injected rats ate more of both the high-fat and high-carbohydrate diets during diet options 1 and 3, but not during option 2 when the high-sucrose and high-fat diets were offered concurrently. In that case, rats did not significantly increase their intake of the high-fat diet. Although carbohydrate source and NPY administration each influenced diet selection, altering the source of carbohydrate had a more marked effect.
Glass
M J
MJ
Department of Psychology, University of Minnesota, Minneapolis 55455, USA.
Cleary
J P
JP
Billington
C J
CJ
Levine
A S
AS
D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D019422:Dietary Sucrose; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005508:Food Deprivation; D005518:Food Preferences / Q000187:drug effects / Q000502:physiology*; D005936:Glucans; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013213:Starch; D003313:Zea mays
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D019422:Dietary Sucrose; D005936:Glucans; D009478:Neuropeptide Y; D013213:Starch