title: Transcription factor-specific requirements for coactivators and their acetyltransferase functions.
abstract: Different classes of mammalian transcription factors-nuclear receptors, cyclic adenosine 3',5'-monophosphate-regulated enhancer binding protein (CREB), and signal transducer and activator of transcription-1 (STAT-1)-functionally require distinct components of the coactivator complex, including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-associated factor (p/CAF), based on their platform or assembly properties. Retinoic acid receptor, CREB, and STAT-1 also require different histone acetyltransferase (HAT) activities to activate transcription. Thus, transcription factor-specific differences in configuration and content of the coactivator complex dictate requirements for specific acetyltransferase activities, providing an explanation, at least in part, for the presence of multiple HAT components of the complex.
authors.affiliation: Howard Hughes Medical Institute, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92093-0648, USA.
authors.forename: E
authors.initials: E
authors.lastname: Korzus
authors.forename: J
authors.initials: J
authors.lastname: Torchia
authors.forename: D W
authors.initials: DW
authors.lastname: Rose
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: R
authors.initials: R
authors.lastname: Kurokawa
authors.forename: E M
authors.initials: EM
authors.lastname: McInerney
authors.forename: T M
authors.initials: TM
authors.lastname: Mullen
authors.forename: C K
authors.initials: CK
authors.lastname: Glass
authors.forename: M G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D050882:CREB-Binding Protein; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006367:HeLa Cells; D051548:Histone Acetyltransferases; D006801:Humans; D008024:Ligands; D009154:Mutation; D009687:Nuclear Proteins / Q000378:metabolism*; D056971:Nuclear Receptor Co-Repressor 1; D056920:Nuclear Receptor Coactivator 1; D056921:Nuclear Receptor Coactivator 3; D011401:Promoter Regions, Genetic; D018168:Receptors, Retinoic Acid / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D050794:STAT1 Transcription Factor; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor
chemical_list: D000123:Acetyltransferases; D050882:CREB-Binding Protein; D018797:Cell Cycle Proteins; D000242:Cyclic AMP; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D051548:Histone Acetyltransferases; D008024:Ligands; D009687:Nuclear Proteins; D056971:Nuclear Receptor Co-Repressor 1; D056920:Nuclear Receptor Coactivator 1; D056921:Nuclear Receptor Coactivator 3; D018168:Receptors, Retinoic Acid; D012097:Repressor Proteins; D050794:STAT1 Transcription Factor; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor; C539127:NCOR1 protein, human; C494079:STAT1 protein, human; C494363:CREBBP protein, human; C538859:NCOA1 protein, human; C538866:NCOA3 protein, human