title: Resorbable versus nonresorbable membranes in combination with Bio-Oss for guided bone regeneration.
abstract: The purpose of this clinical investigation was to compare the new resorbable collagen membrane, Bio-Gide, to the conventional expanded polytetrafluoroethylene material (Gore-Tex) for guided bone regeneration in situations involving exposed implant surfaces. Over a 2-year period, 25 split-mouth patients were treated randomly: one defect site was treated with Bio-Gide and the other defect site with Gore-Tex; all 84 defects were filled with Bio-Oss and covered with the respective membrane. The defect types, their dimensions, and their morphology were measured in detail initially and at re-entry to allow for calculation of the exposed implant surface. Changes in defect surface for both types of membranes were statistically significant (P < .0001); however, no statistical significance (P > .94) could be detected between the two membranes. The mean average percentage of bone fill was 92% for Bio-Gide and 78% for Gore-Tex sites. In the latter group, 44% wound dehiscences and/or premature membrane removal occurred. The resorbable membrane, Bio-Gide, in combination with a bone graft, can be a useful alternative to the well-established expanded polytetrafluoroethylene membranes.
authors.affiliation: Department of Fixed and Removable Prosthodontics and Dental Materials, University of Zurich, Switzerland.
authors.forename: N U
authors.initials: NU
authors.lastname: Zitzmann
authors.forename: R
authors.initials: R
authors.lastname: Naef
authors.forename: P
authors.initials: P
authors.lastname: Schärer
mesh_terms: D000042:Absorption; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D001861:Bone Regeneration; D001862:Bone Resorption / Q000601:surgery; D018786:Bone Substitutes / Q000627:therapeutic use*; D001842:Bone and Bones; D003094:Collagen / Q000737:chemistry / Q000627:therapeutic use; D000044:Dental Abutments; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use*; D010012:Osteogenesis; D011138:Polytetrafluoroethylene; D012086:Reoperation; D013499:Surface Properties; D013529:Surgical Wound Dehiscence / Q000209:etiology; D016896:Treatment Outcome
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D008903:Minerals; D011138:Polytetrafluoroethylene; D003094:Collagen