title: The GUSTO trial and the open artery theory.
abstract: The GUSTO trials have provided continuing insight into the complexities of a simple fundamental relationship: early and sustained coronary perfusion in patients with acute myocardial infarction leads to lower mortality and morbidity. To a large extent, the GUSTO trials have attempted to develop approaches to therapy that will ensure the highest early rate of reperfusion with the least risk. A table provides a summary of the completed trials and those that are planned in attempts to provide further knowledge in the continuing quest to improve the plight of patients with acute myocardial infarction.
authors.affiliation: Duke Clinical Research Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Califf
mesh_terms: D017023:Coronary Angiography; D006801:Humans; D008955:Models, Cardiovascular; D009017:Morbidity; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D015425:Myocardial Reperfusion; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence