title: Radiation-based approaches to the management of T3 prostate cancer.
abstract: Locally advanced prostate cancer is rarely cured by conventional external beam radiation alone. Although occult micrometastatic disease is common, so is locally persistent tumor. This may provide the source of symptomatic local recurrence or metastases in the future. Efforts to improve local control through radiation dose escalation and through the use of neoadjuvant androgen suppression are showing promise. Adjuvant androgen suppression is also under study for those at highest risk of disseminated disease.
authors.affiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Zietman
authors.forename: J C
authors.initials: JC
authors.lastname: Westgeest
authors.forename: W U
authors.initials: WU
authors.lastname: Shipley
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists