Protein kinase C in IL-2 signal transduction.
Interleukin-2 (IL-2), secreted principally by activated helper T-cells, plays a pivotal role in the generation and regulation of the immune response. The various biologic functions of IL-2 have been the focus of intensive study over the years and have been well worked out. By contrast, an understanding of the intracellular signals coupled to the IL-2 receptor and responsible for mediating IL-2 effects in T-cells is far less developed, and the role that protein kinase C (PKC) may play in the various cellular responses to IL-2 receptor activation is unclear. In this article we will discuss IL-2, its receptors, and IL-2 signal transduction in relation to the physiological roles PKC activation may play in IL-2-mediated activation of T-cells and other hematopoietic cells.
Lu
Y
Y
Cellular Neurobiology Group, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada.
Durkin
J P
JP
D006801:Humans; D007376:Interleukin-2 / Q000276:immunology / Q000502:physiology*; D011493:Protein Kinase C / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
D007376:Interleukin-2; D011493:Protein Kinase C