Stimulation of 5-HT(2A/2C) receptors within specific hypothalamic nuclei differentially antagonizes NPY-induced feeding.
The present study examined the impact of the 5-HT(2A/2C) agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the feeding-stimulant action of neuropeptide Y (NPY) injected into three hypothalamic sites, the paraventricular nucleus (PVN), the perifornical hypothalamus (PFH) and the ventromedial nucleus (VMH). Injections of NPY (100-200 pmol) into each region potentiated food intake. Pretreatment with DOI (5-20 nmol) into the PVN effectively suppressed feeding elicited by PVN NPY (100 pmol). In contrast, DOI injections into the PFH and VMH failed to modify NPY-stimulated eating. This suggests that 5-HT(2A/2C) receptor modulation of NPY feeding within the hypothalamus is localized to the PVN.
Currie
P J
PJ
Department of Psychology, Wayne State University, Detroit, MI 48202, USA.
Coscina
D V
DV
D000662:Amphetamines / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008845:Microinjections; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000502:physiology*; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*
D000662:Amphetamines; D009478:Neuropeptide Y; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine