UV induced erythema evaluated 24 h post-exposure by skin reflectance and laser Doppler flowmetry is identical in healthy persons and patients with cutaneous malignant melanoma and basal cell cancer.
Twenty-one patients with invasive cutaneous malignant melanoma and 19 patients with basal cell skin cancer and 29 healthy volunteers were phototested on non-UV exposed buttock skin to examine their 24 h reaction to a series of increasing doses of simulated sunlight with 25% dose increments. Skin pigmentation at the phototest sites was determined by skin reflectance before testing to assure an equal level of constitutive skin pigmentation in the 3 groups. Erythema reactions were scored visually 24 hours post-exposure and objective measurements of erythema were performed by skin reflectance and laser Doppler flowmetry. In adjacent non-irradiated skin the redness was also quantified to determine the increase in redness in irradiated skin compared to non-irradiated skin. Constitutional skin pigmentation correlated well to UV sensitivity (r = 0.75) and skin redness measured by skin reflectance technique correlated to laser Doppler flowmetry (r = 0.86). No significant differences in UV doses to barely perceptible erythema or to the higher erythema grades were found between the two skin tumour groups and the control group, and no significant differences were found in skin reflectance measured redness or in laser Doppler flowmetry of any erythema reactions between the 3 groups. The 24 h erythema reaction to sunlight can therefore not be used to distinguish patients with invasive cutaneous malignant melanoma or basal cell carcinoma from normal persons.
Lock-Andersen
J
J
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Denmark. lock@post5.tele.dk
Gniadecka
M
M
De Fine Olivarius
F
F
Dahlstrøm
K
K
Wulf
H C
HC
D004890:Erythema; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008545:Melanoma / Q000503:physiopathology*; D018295:Neoplasms, Basal Cell / Q000503:physiopathology*; D012867:Skin / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000503:physiopathology*; D012880:Skin Pigmentation / Q000528:radiation effects*; D014466:Ultraviolet Rays