Preferential localization of human CD5+ B cells in the peritoneal cavity.
In a transgenic mouse model of autoimmune haemolytic anaemia, CD5+ B lymphocytes localized in the peritoneal cavity are shown to play an important role in the onset of autoimmune disease. The authors have examined whether CD5+ B cells are present in the peritoneal cavity of 12 human individuals with non-invasive gastrointestinal tumours and found that in humans CD5+ B cells preferentially lodge in the peritoneal cavity as compared to the peripheral blood and spleen while the numbers of the peritoneal B lymphocytes in humans are much lower than in mice and vary widely between individuals.
Nisitani
S
S
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
Murakami
M
M
Akamizu
T
T
Okino
T
T
Ohmori
K
K
Mori
T
T
Imamura
M
M
Honjo
T
T
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D018956:CD5 Antigens / Q000276:immunology*; D002452:Cell Count; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology*
D018956:CD5 Antigens