title: Unconventional myosins in cell movement, membrane traffic, and signal transduction.
abstract: In the past few years genetic, biochemical, and cytolocalization data have implicated members of the myosin superfamily of actin-based molecular motors in a variety of cellular functions including membrane trafficking, cell movements, and signal transduction. The importance of myosins is illustrated by the identification of myosin genes as targets for disease-causing mutations. The task at hand is to decipher how the multitude of myosins function at both the molecular and cellular level-a task facilitated by our understanding of myosin structure and function in muscle.
authors.affiliation: Department of Biology, Yale University 342 KBT, New Haven, CT 06520, USA.
authors.forename: V
authors.initials: V
authors.lastname: Mermall
authors.forename: P L
authors.initials: PL
authors.lastname: Post
authors.forename: M S
authors.initials: MS
authors.lastname: Mooseker
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002465:Cell Movement; D006309:Hearing; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009218:Myosins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015388:Organelles / Q000502:physiology*; D015398:Signal Transduction; D014785:Vision, Ocular
chemical_list: D009218:Myosins