Pentasomy 8q in myelodysplasia.
Trisomy 8 and, less commonly tetrasomy 8, are karyotypic aberrations found in myeloid malignancies. We describe a unique case of acute myeloid leukemia with partial pentasomy 8 resulting from duplication of isochromosome 8q, and discuss its possible roles in leukemogenesis.
Kwong
Y L
YL
University Department of Medicine, Queen Mary Hospital, Hong Kong.
Chan
T K
TK
D000328:Adult; D016026:Bone Marrow Transplantation; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D018404:Isochromosomes; D007621:Karyotyping; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000628:therapy