title: Hepatitis C virus genotypes implicated in mixed cryoglobulinemia.
abstract: Recent reports suggest that hepatitis C virus (HCV) might be a causative agent of mixed cryoglobulinemia. To determine whether the HCV genotype is a factor implicated in the onset of cryoglobulinemia, genotyping by direct sequencing of polymerase chain reaction products of the 5' non coding region was carried out among 45 HCV-infected patients. Genotypes 1 and 2 were found more prevalent in symptomatic cryoglobulinemia patients. Due to the presence of genotypes 4 and 5 found in this panel of French patients (9.3%), HCV genotyping based on sequence determination is recommended.
authors.affiliation: Laboratoire de Bactériologie-Virologie, Hôpital Avicenne, Bobigny, France.
authors.forename: Q T
authors.initials: QT
authors.lastname: Nguyen
authors.forename: M
authors.initials: M
authors.lastname: Leruez-Ville
authors.forename: F
authors.initials: F
authors.lastname: Ferrière
authors.forename: P
authors.initials: P
authors.lastname: Cohen
authors.forename: D
authors.initials: D
authors.lastname: Roulot-Marullo
authors.forename: T
authors.initials: T
authors.lastname: Coste
authors.forename: P
authors.initials: P
authors.lastname: Dény
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
mesh_terms: D016022:Case-Control Studies; D003449:Cryoglobulinemia / Q000821:virology*; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D012367:RNA, Viral