[Molecular biology findings in amyotrophic lateral sclerosis].
At presently, the etiology and pathogenesis of amyotrophic lateral sclerosis (ALS) are unknown. In recent years, the genetic background of hereditary motor neuron diseases has been partly defined. In particular, these advances represent an opportunity to improve our understanding of the pathogenesis of the familial and sporadic forms of ALS and thus provide a basis for rational therapeutic approaches. In this article, recent findings on the pathogenesis of the familial form of ALS and their implications for the sporadic form are discussed.
Bachus
R
R
Neurologische Klinik, Universitätsklinikum Charité, Humboldt-Universität, Berlin.
Claus
A
A
Meyer
T
T
Riepe
M
M
Ludolph
A C
AC
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000503:physiopathology; D004252:DNA Mutational Analysis; D018846:Excitatory Amino Acids / Q000502:physiology; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase / Q000235:genetics
D018846:Excitatory Amino Acids; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase