Cyclosporine: update on pharmacology, analytical techniques and therapeutic monitoring.
The Authors relate about the current state of knowledge on Cyclosporin A metabolism, mechanism of action, toxic potential, necessity of therapeutic monitoring. The methods for measurement of Cyclosporin A and its metabolites and the study of their immunosuppressive activity are described. Their use for measurement of Cyclosporin G is discussed.
Santori
L
L
Laboratorio di Analisi Cliniche e Microbiologia, Ospedale Civile, Piacenza.
Rastelli
M
M
Arena
B
B
Morleo
M A
MA
D000818:Animals; D016572:Cyclosporine / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D016572:Cyclosporine