title: Involvement of interleukin-3 in delayed-type hypersensitivity.
abstract: The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell-dependent sensitization to tumor cells. These findings reveal a critical role for IL-3 in some forms of delayed-type hypersensitivity.
authors.affiliation: Department of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: N
authors.initials: N
authors.lastname: Mach
authors.forename: C S
authors.initials: CS
authors.lastname: Lantz
authors.forename: S J
authors.initials: SJ
authors.lastname: Galli
authors.forename: G
authors.initials: G
authors.lastname: Reznikoff
authors.forename: M
authors.initials: M
authors.lastname: Mihm
authors.forename: C
authors.initials: C
authors.lastname: Small
authors.forename: R
authors.initials: R
authors.lastname: Granstein
authors.forename: S
authors.initials: S
authors.lastname: Beissert
authors.forename: M
authors.initials: M
authors.lastname: Sadelain
authors.forename: R C
authors.initials: RC
authors.lastname: Mulligan
authors.forename: G
authors.initials: G
authors.lastname: Dranoff
mesh_terms: D000818:Animals; D003877:Dermatitis, Contact; D006410:Hematopoiesis; D006968:Hypersensitivity, Delayed; D007377:Interleukin-3 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016296:Mutagenesis; D009374:Neoplasms, Experimental / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007377:Interleukin-3