title: Evidence that brief stress may induce the acute phase response in rats.
abstract: Exposing rats to a single session of inescapable tail shock (IS) reduces corticosteroid binding globulin (CBG) 24 h later (Fleshner et al., Endocrinology 136: 5336-5342, 1995). The present experiments examined whether reductions in CBG are differentially affected by controllable vs. identical uncontrollable tail shock, are mediated by IS-induced glucocorticoid elevation, or reflect IS-induced activation of the acute phase response and whether IS produces fever. The results demonstrate that 1) equivalent reductions in CBG are observed in response to escapable tail shock or yoked IS, 2) IS-induced CBG reduction is not blocked by adrenalectomy in rats that receive basal corticosteroid replacement or by pretreatment with RU-38486, and 3) IS appears to activate the acute phase response, since IS reduces serum levels of an acute-phase negative reactant (CBG), increases serum levels of acute-phase positive reactants (haptoglobin and alpha 1-acid glycoprotein), and increases core body temperature 20-24 h later.
authors.affiliation: Department of Psychology, University of Colorado at Boulder 80309, USA.
authors.forename: T
authors.initials: T
authors.lastname: Deak
authors.forename: J L
authors.initials: JL
authors.lastname: Meriwether
authors.forename: M
authors.initials: M
authors.lastname: Fleshner
authors.forename: R L
authors.initials: RL
authors.lastname: Spencer
authors.forename: A
authors.initials: A
authors.lastname: Abouhamze
authors.forename: L L
authors.initials: LL
authors.lastname: Moldawer
authors.forename: R E
authors.initials: RE
authors.lastname: Grahn
authors.forename: L R
authors.initials: LR
authors.lastname: Watkins
authors.forename: S F
authors.initials: SF
authors.lastname: Maier
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D004597:Electroshock; D004924:Escape Reaction; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors; D014156:Transcortin / Q000096:biosynthesis*
chemical_list: D014156:Transcortin; D003345:Corticosterone