Regulatory feedback pathways in the thymus.
The idea that thymocytopoiesis may be subject to feedback regulation by mature lymphocytes is proposed on the basis of recent data from in vitro experimental models. Analysis of the data using mathematical models, presented here by Ramit Mehr and colleagues, suggests possible feedback control mechanisms in T-cell development.
Mehr
R
R
Dept of Molecular Biology, Princeton University, NJ 08544, USA. ramit@princeton.edu
Perelson
A S
AS
Fridkis-Hareli
M
M
Globerson
A
A
D000818:Animals; D002455:Cell Division / Q000502:physiology; D005246:Feedback; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex / Q000502:physiology; D051379:Mice; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D013950:Thymus Gland / Q000276:immunology*