title: N-aralkyl substitution of 2-aminoindans. Synthesis and their inotropic and chronotropic activity in isolated guinea pig atria.
abstract: Amino substitution of rigid forms of dopamine 4,5-dihydroxy-2-aminoindan and 5,6-dihydroxy-2-aminoindan with aralkyl functionalities were carried out to investigate the role of such structural modifications upon cardiac inotropic-chronotropic activity. Compounds synthesized demonstrated a modest inotropic selectivity, while one of them, described as 5,6-dihydroxy-N-[2-(4-hydroxyphenyl)-1-methylethyl]-2-aminoindan hydrobromide 17, showed a marked inotropic action on isolated heart tissue.
authors.affiliation: Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela.
authors.forename: J A
authors.initials: JA
authors.lastname: Pérez
authors.forename: J N
authors.initials: JN
authors.lastname: Domínguez
authors.forename: J E
authors.initials: JE
authors.lastname: Angel
authors.forename: Z
authors.initials: Z
authors.lastname: Duerto de Pérez
authors.forename: M M
authors.initials: MM
authors.lastname: Salazar-Bookaman
authors.forename: H
authors.initials: H
authors.lastname: Acosta
authors.forename: J E
authors.initials: JE
authors.lastname: Charris
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*
chemical_list: D002316:Cardiotonic Agents; D007189:Indans; C006545:2-aminoindan