Risk factors for locoregional recurrence of scar carcinoma.
BACKGROUND
Squamous cell carcinoma (SCC) arising from scar tissue is rare and has a higher rate of recurrence than SCC arising in sunlight-damaged skin. The risk factors related to locoregional recurrence in scar carcinoma were analysed retrospectively.


METHODS
Ninety-one patients with SCC arising from scar tissue treated from January 1980 to January 1992 were studied. The following factors were evaluated using univariate and multivariate methods for locoregional recurrence: patient age, sex, tumour size, anatomical location, histological differentiation, cause of scar and regional lymph node dissection.


RESULTS
With a median follow-up of 30 months locoregional recurrence developed in 27 patients. The median interval to recurrence was 15 months. Sex (P = 0.0278), tumour size (P = 0.0491), and tumour grade (P = 0.0019) were found to be associated with recurrent disease by univariate analysis, but on multivariate analysis only sex and tumour grade were risk factors for recurrence.


CONCLUSIONS
Careful follow-up after treatment is recommended especially for female patients and those with high-grade tumours.
Eroğlu
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A
Department of Surgical Oncology, Süleyman Demirel University Medical School, Isparta, Turkey.
Camlibel
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S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D002921:Cicatrix; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010019:Osteomyelitis / Q000473:pathology; D011832:Radiation Injuries / Q000473:pathology; D012307:Risk Factors; D012867:Skin / Q000293:injuries