Influences of immunosuppressive agents, FK506 and cyclosporin on systemic Candida albicans infection in mice.
The effects of the immunosuppressive agents FK506 (tacrolimus) and cyclosporin (CyA) on Candida albicans infection in mice were compared with those of cyclophosphamide. FK506 and CyA did not exacerbate C. albicans infection in mice when the effects were determined on the basis of survival ratio and colony forming units (CFU) in the kidney, although cyclophosphamide (CY) impaired the host defence mechanisms of mice against C. albicans infection. The effects of FK506 and CyA on the body weight of mice, histopathological changes of lymphoid tissues and formation of granulomas in kidney were also studied in comparison with those of CY.
Ito
E
E
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Tanaka
Y
Y
D000818:Animals; D001921:Brain / Q000473:pathology; D002177:Candidiasis / Q000276:immunology / Q000401:mortality* / Q000473:pathology; D003520:Cyclophosphamide / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology*; D006099:Granuloma; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007672:Kidney Cortex / Q000473:pathology; D008221:Lymphoid Tissue / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013234:Stem Cells; D016019:Survival Analysis; D016559:Tacrolimus / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide; D016559:Tacrolimus