title: Pure small cell carcinoma of the prostate.
abstract: Pure small cell carcinoma of the prostate is a rare anaplastic tumour. This report presents the clinicopathological findings of two patients presenting with this disease. Immunohistochemistry was positive for protein gene product 9.5, neurone specific enolase and calcitonin. Staining was negative for prostate specific antigen and prostate acid phosphatase. androgen ablation has no place in the management of this lesion and patients with this disease should be managed as if they have a neuroendocrine tumour.
authors.affiliation: Department of Urology, Royal Free Hospital School of Medicine, London, UK.
authors.forename: S S
authors.initials: SS
authors.lastname: Sandhu
authors.forename: A
authors.initials: A
authors.lastname: Denton
authors.forename: M
authors.initials: M
authors.lastname: Jarmulowicz
authors.forename: K
authors.initials: K
authors.lastname: Pigott
authors.forename: A V
authors.initials: AV
authors.lastname: Kaisary
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002116:Calcitonin / Q000378:metabolism; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D013869:Thiolester Hydrolases / Q000378:metabolism; D043222:Ubiquitin Thiolesterase
chemical_list: D014408:Biomarkers, Tumor; D002116:Calcitonin; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; D010751:Phosphopyruvate Hydratase