Inhibition of the development of myringosclerosis by local administration of fenspiride, an anti-inflammatory drug.
Earlier studies have revealed a relationship between the development of myringosclerosis and oxygen-derived free radicals. The latter can be blocked by the anti-inflammatory drug fenspiride. The present study was undertaken to test the ability of fenspiride to prevent myringosclerosis from developing during healing of the tympanic membrane. Myringotomized rats were treated with either topical applications or intraperitoneal injections of fenspiride for 12 days, after which the tympanic membranes were examined by otomicroscopy and studied histologically by light microscopy. Topically applied fenspiride was found to inhibit the development of sclerotic lesions, whereas intraperitoneal injections were ineffective.
Mattsson
C
C
Department of Otorhinolaryngology, University Hospital of Umeå, Sweden.
Hellström
S
S
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012598:Sclerosis / Q000517:prevention & control; D013141:Spiro Compounds / Q000008:administration & dosage*; D014432:Tympanic Membrane
D000893:Anti-Inflammatory Agents; D013141:Spiro Compounds; C084775:fenspiride