title: Central nervous system hemangiomatosis in early childhood.
abstract: Two cases of hemangiomatosis are reported, a girl of 3 years of age and a boy 2 years of age, both with central nervous system (CNS) involvement. In the first, the CNS lesions were asymptomatic; in the second, symptomatic. Magnetic resonance imaging was used both to identify the lesions and to follow their evolutions. In the first case, the CNS lesions involuted in parallel with those in skin and liver. In the second, while there was no obvious resolution of the CNS lesions, there was a decrease in the level of urine basic fibroblast growth factor, indicating the lesions were probably involuting. Serial magnetic resonance imaging studies and urine assays of basic fibroblastic growth factor have important roles to play in following CNS involvement in hemangiomatosis.
authors.affiliation: Department of Pediatrics, Floating Hospital for Children, Boston, Massachusetts 02111, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Capin
authors.forename: S M
authors.initials: SM
authors.lastname: Gottlieb
authors.forename: N P
authors.initials: NP
authors.lastname: Rosman
mesh_terms: D001921:Brain / Q000002:abnormalities; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000652:urine; D006391:Hemangioma / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D011994:Recombinant Proteins; D013256:Steroids / Q000627:therapeutic use
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D013256:Steroids; D016222:Fibroblast Growth Factor 2