title: Off-resonance experiments and contrast agents to improve magnetic resonance imaging.
abstract: The effect of off-resonance irradiation on the water proton NMR signal intensity has been investigated as follows: (a) in the presence of a paramagnetic probe like manganese(II); (b) in the presence of bovine serum albumin (BSA) and two gadolinium(III) complexes, Gd-DTPA and Gd-BOPTA; (c) in the presence of cross-linked BSA and the two above-mentioned gadolinium(III) complexes. The experimental data have been rationalized on the basis of the available theoretical models. The effectiveness of the two complexes as contrast agents for MRI has been predicted. It is shown that contrast agents providing comparable longitudinal and transverse relaxation rate enhancements are those of general interest for off-resonance magnetization transfer-MRI.
authors.affiliation: Department of Chemistry, University of Florence, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Bertini
authors.forename: C
authors.initials: C
authors.lastname: Luchinat
authors.forename: G
authors.initials: G
authors.lastname: Parigi
authors.forename: G
authors.initials: G
authors.lastname: Quacquarini
authors.forename: P
authors.initials: P
authors.lastname: Marzola
authors.forename: F M
authors.initials: FM
authors.lastname: Cavagna
mesh_terms: D000818:Animals; D002417:Cattle; D003287:Contrast Media; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008280:Magnetics; D008536:Meglumine / Q000031:analogs & derivatives; D008962:Models, Theoretical; D009942:Organometallic Compounds; D019047:Phantoms, Imaging; D011856:Radiographic Image Enhancement / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA