Dopamine D1-deficient mutant mice do not express the late phase of hippocampal long-term potentiation.
The possible involvement of the dopamine D1 receptor subtype in mechanisms of long-term potentiation (LTP) of the Schaffer collateral-commissural input of CA1 neurones was investigated using D1-deficient mutant mice. In transversal hippocampus slices from mice lacking the D1 receptor a normal post-tetanic and short-term potentiation could be induced after applying a triple 100 Hz tetanization. However, the potentiated fEPSP in the mutant mice declined to control value about 140 min following tetanization, whereas in the wild type mice a normal, non-decremental LTP was observed. These data support the idea that besides the glutamatergic system, the synergistic activation of dopaminergic synapses is necessary for LTP maintenance.
Matthies
H
H
Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto-von-Guericke University, Magdeburg, Germany.
Becker
A
A
Schröeder
H
H
Kraus
J
J
Höllt
V
V
Krug
M
M
D000818:Animals; D001552:Benzazepines / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000502:physiology; D004558:Electric Stimulation; D005838:Genotype; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D013569:Synapses / Q000502:physiology; D013997:Time Factors
D001552:Benzazepines; D017447:Receptors, Dopamine D1; D004298:Dopamine