title: Resistance to blood flow in nonuniform capillaries.
abstract: OBJECTIVE
  Microvessels in living tissues an not uniform cylinders, and red blood cells (RBCs) are continually deformed when traversing them. This may contribute to higher resistance to blood flow observed in microvessels compared with that in corresponding uniform glass tubes. Here, a theoretical model was used to estimate flow resistance in nonuniform capillaries and its dependence on hematocrit, flow rate, and mechanical properties of RBCs.
  
  
  METHODS
  Single-file motion of RBCs through capillaries with sinusoidally varying cross-sections was simulated, assuming axisymmetrical geometry. Effects of cell membrane shear viscosity and elasticity were included. Lubrication theory was used to describe the plasma flow.
  
  
  RESULTS
  Predicted resistance to blood flow in capillaries with variable cross-sections was substantially higher than in uniform vessels with the same mean diameters. Resistance depended on vessel geometry, flow rate, and hematocrit. At tube hematocrit 30%, the increase in resistance was 40%-58% when diameter varied between 4.5 and 6 microns with wavelength 20 microns and 58%-77% for variations between 4 and 5 microns with wavelength 10 microns. Larger relative increases in resistance were predicted for RBCs with increased membrane shear viscosity.
  
  
  CONCLUSIONS
  Effects of transient RBC deformations in irregular capillaries contribute significantly to blood flow resistance in capillaries. However, this effect is not sufficient to account for the flow resistance observed in living tissues.
authors.affiliation: Department of Physiology, University of Arizona, Tucson 85724-5051, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Secomb
authors.forename: R
authors.initials: R
authors.lastname: Hsu
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D006801:Humans; D008833:Microcirculation; D008954:Models, Biological; D008962:Models, Theoretical; D014655:Vascular Resistance