Right ventricular regional function using MR tagging: normals versus chronic pulmonary hypertension.
Right ventricular (RV) regional function, in both normal and diseased states, is not well characterized. Using 1D MR myocardial tagging, RV and septal intramyocardial segmental shortening was noninvasively measured in ten healthy subjects and in seven patients with chronic pulmonary hypertension. The normal RV free wall regional shortening was not uniform. A pattern of increasing RV free wall short-axis shortening was found from the RV outflow tract to the RV apex, and a more complex pattern of RV free wall long-axis shortening was observed. Both regional short- and long-axis shortening were globally reduced in pulmonary hypertension patients, with the greatest decreases in the RV outflow tract and in the basal septal wall region. Regional RV function can be quantitatively evaluated using MR tagging to determine the impact of chronic pulmonary hypertension on RV performance.
Fayad
Z A
ZA
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, USA.
Ferrari
V A
VA
Kraitchman
D L
DL
Young
A A
AA
Palevsky
H I
HI
Bloomgarden
D C
DC
Axel
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D018497:Ventricular Dysfunction, Right / Q000473:pathology* / Q000503:physiopathology; D016278:Ventricular Function, Right / Q000502:physiology*