[The role of nm23 protein in progression of sporadic adenocarcinoma of the large intestine].
We analysed the nm23 protein expression in the selected group of 80 patients with sporadic colorectal cancer. nm23 protein was detected in cytoplasm with use of monoclonal anti nm23 antibody. Decreased expression of nm23 protein was found in 58/80 (72.5%) colorectal cancer samples. Positive reaction was found more often in the group A and B according to Dukes, than in the C and D. The difference was statistically significant at p < 0.05, and the occurrence was 75% vs. 15.63% respectively. We also found statistically significant difference in nm23 protein expression in well differentiated (G1) and poorly (G3) and intermediate (G2) differentiated. The positive reaction was observed in 85.71% in G1 group and 12.92% in G2 and G3 together. On the base of our study we suggest a usefulness of histochemical identification of nm23 protein expression in evaluation of metastatic potential of colorectal cancer.
Paluszkiewicz
P
P
Kliniki Chirurgii Urazowej Akademii Medycznej w Lublinie.
Pawłowska-Wakowicz
B
B
Karski
J
J
D000230:Adenocarcinoma / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000276:immunology; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000276:immunology; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D003593:Cytoplasm / Q000737:chemistry / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D014157:Transcription Factors / Q000032:analysis* / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins