Neonatal outcome after active perinatal management of the very premature infant between 23 and 27 weeks' gestation.
OBJECTIVE
To record the effect of aggressive perinatal management on neonatal outcome in the very premature infant.


METHODS
A retrospective chart review of 114 infants born between 23 and 27 weeks' gestation, managed by one perinatal transport service at one hospital between July 1989 and December 1993. Fetuses > 23 weeks' gestation were considered viable and were managed with tocolytics, antibiotics, and surfactant at the discretion of the treating physician. Morbidity and mortality rates in the first 6 months, including stillbirths were analyzed. A major neurologic condition was defined as ultrasonographic evidence of grade 3 or 4 intraventricular hemorrhage or periventricular leukomalacia.


RESULTS
Both neonatal mortality rate and the incidence of stillbirths decreased with advancing gestational age. Of 24 infants born at 23 weeks' gestation, 33% were stillborn and 13% were alive at 6 months. This survival rate improved to 48% for infants delivered at 24 weeks' gestation, and to 68%, 75%, and 71% for those delivered at 25, 26, and 27 weeks' gestation, respectively. The percentage of infants who survived without a major neurologic condition increased with advancing gestational age at delivery from 13% at 23 weeks' gestation to 40% at 24 weeks, 48% at 25 weeks, 70% at 26 weeks, and 71% at 27 weeks. The incidence of retinitis of prematurity, respiratory complications, and days spent in the hospital decreased with greater gestational age.


CONCLUSIONS
An active plan of management for all gestations of > 23.9 weeks seems appropriate.
Kramer
W B
WB
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA.
Saade
G R
GR
Goodrum
L
L
Montgomery
L
L
Belfort
M
M
Moise
K J
KJ
D000293:Adolescent; D000328:Adult; D004453:Echoencephalography; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000628:therapy; D007902:Length of Stay; D017283:Neonatal Nursing / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies; D016896:Treatment Outcome