title: Sepsis at a neonatal intensive care unit: a four-year retrospective study (1989-1992).
abstract: During the 4-year period 1989-1992, 18,227 neonates were born at Kaplan Hospital and 614 (3.4%) were admitted to the neonatal intensive care unit. During this period, 120 episodes (6.6/1000 live births) of neonatal sepsis were recorded in 109 neonates (6/1000 live births). The incidence of early-onset sepsis was 19/109 (17%). The main pathogens of early-onset sepsis were S. agalactiae (42%) and E. coli (32%). Seven of the 8 S. agalactiae cases were recorded during 1989-1990. The main pathogens of late-onset sepsis were Klebsiella spp. (31%), coagulase-negative staphylococci (18%) and Candida spp (16%). There were 11 cases (10%) of meningitis, 5 due to Klebsiella spp. The overall fatality rate due to sepsis was 14% (0.8/1000 live births) with an early-onset sepsis death rate of 37%. The mortality from S. agalactiae sepsis was 63%. The main trends recorded during the period of the study were 1) the emergence of S. agalactiae as the main pathogen of early-onset sepsis, followed by a sharp decrease in its incidence during the last part of the study, 2) the emergence of extremely virulent, multi-antibiotic-resistant Klebsiella organisms, and 3) the persistent high incidence of Candida sepsis.
authors.affiliation: Department of Neonatology, Kaplan Hospital, Rehovot, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Leibovitz
authors.forename: O
authors.initials: O
authors.lastname: Flidel-Rimon
authors.forename: A
authors.initials: A
authors.lastname: Juster-Reicher
authors.forename: M
authors.initials: M
authors.lastname: Amitay
authors.forename: A
authors.initials: A
authors.lastname: Miskin
authors.forename: Y
authors.initials: Y
authors.lastname: Barak
authors.forename: B
authors.initials: B
authors.lastname: Mogilner
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D002177:Candidiasis / Q000382:microbiology; D005260:Female; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000382:microbiology*; D007363:Intensive Care Units, Neonatal; D007557:Israel; D008297:Male; D012189:Retrospective Studies
chemical_list: D000890:Anti-Infective Agents