[Genetic factors in familial combined hyperlipidemia and insulin resistance syndrome associated with dyslipidemia].
Familial combined hyperlipidemia, (FCHL) and dyslipidemia occurring in insulin resistant syndrome (IRS) share similar lipid abnormalities. Additionally insulin resistance is frequent in families affected by FCHL. The genetics of FCHL, an oligogenic disorder influenced by environmental factors is not established. Many genes that modulate dyslipidemia such as, LPL, apo E, the cluster A I-C III-A IV, have been identified. However the major gene which determines hypertriglyceridemia remains unknown. The community between HCF and insulin resistance syndrome might have:--either a metabolic origin: the increase in FFA which is a characteristic of IRS, capable to stimulate the hepatic production of triglycerides;--and/or a common genetic mechanism involving the alteration of many genes implied in the control of lipoprotein metabolism and insulin sensitivity.
Moulin
P
P
Service d'Endocrinologie et des Maladies de la Nutrition, Hôpital de l'Antiquaille, Lyon.
D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000235:genetics* / Q000378:metabolism; D006949:Hyperlipidemias / Q000150:complications* / Q000235:genetics* / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics*; D008077:Lipoproteins, LDL / Q000737:chemistry
D008077:Lipoproteins, LDL