title: Prognostic factors in squamous cell carcinoma of the penis and implications for management.
abstract: OBJECTIVE
  To determine the clinical and pathological features, methods and outcome of management in squamous cell carcinoma of the penis (SCCP).
  
  
  METHODS
  A retrospective study was carried out of 42 patients (mean age 63 years, range 28-86) with a histological diagnosis of SCCP. The disease stage, grade, treatment of primary tumour, lymph node disease and survival were recorded; the mean follow-up was 4 years (range 1.5-25).
  
  
  RESULTS
  The disease stage was T1 in 24 patients (57%), T2 in 14 (33%), T3 in three (7%) and T4 in one (2%); the tumour grade was well differentiated in 20 (47%), moderately differentiated in 14 (33%) and poorly differentiated in three (7%). Eight patients had histologically confirmed inguinal node disease at presentation, six of whom underwent lymph node dissection, while two underwent radiotherapy. Five patients developed inguinal node disease during follow-up (mean 10 months, range 4-21). Three of these patients were irradiated and two underwent lymph node dissection. Six patients (14%) had local recurrence, five of whom were managed surgically. One patient developed a local recurrence 11 years after initial surgery. Seven patients died from their disease (17%); four died within 2 years, being patients with high-stage and/or high-grade disease.
  
  
  CONCLUSIONS
  Modern management should include a standard staging classification and treatment protocols to maximize survival.
authors.affiliation: Department of Urology, Meath Hospital, Dublin, Ireland.
authors.forename: A B
authors.initials: AB
authors.lastname: Adeyoju
authors.forename: J
authors.initials: J
authors.lastname: Thornhill
authors.forename: J
authors.initials: J
authors.lastname: Corr
authors.forename: R
authors.initials: R
authors.lastname: Grainger
authors.forename: T E
authors.initials: TE
authors.lastname: McDermott
authors.forename: M
authors.initials: M
authors.lastname: Butler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010412:Penile Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome