Loss of nerve endings in the spinal dorsal horn after a peripheral nerve injury. An anatomical study in Macaca fascicularis monkeys.
In patients, the long-term outcome of injuries to sensory nerves is poor. This is only partly due to mismatching of regenerating axons at the transection site. We found in the macaque monkey that 70% of the transganglionic labelling in the spinal dorsal horn was still significantly reduced 21 months after transection and suturing of the sensory radial nerve. The reduction was evenly distributed throughout the terminal field of nerve endings, which were labelled with a mixture of the intra-axonal nerve tracer wheat germ agglutinin-horseradish peroxidase conjugate and pure horseradish peroxidase.
Liss
A G
AG
Department of Anatomy, Uppsala University, Sweden.
Wiberg
M
M
D000818:Animals; D001370:Axonal Transport; D005260:Female; D008252:Macaca fascicularis / Q000033:anatomy & histology* / Q000502:physiology; D008297:Male; D008959:Models, Neurological; D009411:Nerve Endings / Q000473:pathology* / Q000648:ultrastructure; D009474:Neurons / Q000473:pathology*; D011826:Radial Nerve / Q000293:injuries* / Q000502:physiology; D013116:Spinal Cord / Q000033:anatomy & histology* / Q000473:pathology*; D013997:Time Factors; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate