Expression of lung resistance-related protein (LRP) in non-small cell lung carcinomas of smokers and non-smokers and its predictive value for doxorubicin resistance.
Immunohistochemical methods were used to determine the expression of the lung resistance-related protein (LRP) in 87 cases of untreated non-small cell lung carcinoma. LRP expression was detected in 39 patients (45%). A significant correlation between LRP expression and tumor resistance to doxorubicin was found (p=0.03, Fisher's exact test). An inter-relationship between LRP expression and gender, age, stage, lymph node status and survival times was not observed. Furthermore, a relationship between LRP expression and proliferation (cell cycle phases, take rate of lung tumors in nude mice and cyclin A expression) was not detectable. However, a correlation of borderline significance was noticed between LRP expression and the patients' smoking habits. Carcinomas in heavy smokers (more than 30 cigarettes daily) were more frequently LRP-positive than carcinomas found in non-smokers (p=0.09, Fisher's exact test).
Volm
M
M
Department of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg.
Mattern
J
J
Koomägi
R
R
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D004317:Doxorubicin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012907:Smoking / Q000378:metabolism*; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D009363:Neoplasm Proteins; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein