Effects of arginine, growth hormone-releasing hormone (GHRH) and neostigmine administered singly or in paired combinations on growth hormone (GH) release in pigs.
In human, arginine (ARG) induces growth hormone (GH) release, probably via a decrease in somatostatinergic tone. To assess the mechanism by which ARG mediates GH release in pigs, the effects on plasma GH release of ARG (1 g/kg body weight, infused between times -15 and -5 min), growth hormone-releasing hormone (GHRH, 2 micrograms/kg, at time 0 min) and neostigmine, a cholinesterase inhibitor (NEO, 50 micrograms/kg, at time 4 min), administered intravenously singly or in paired combinations were investigated in piglets between times -30 and 100 min. ARG and GHRH had additive effects on GH release. No potentialization was observed between the two treatments. GH response was higher following the combination of NEO and GHRH treatments than after NEO or GHRH given alone. NEO had no further effect on ARG-induced GH secretion. Therefore, our results suggest that the mechanism by which ARG stimulates GH secretion in pig is the same as in human.
Cochard
A
A
Laboratoire du jeune ruminant, Inra-Ensar, Rennes, France. cochard@roazhon.inra.fr
Guilhermet
R
R
Bonneau
M
M
D000818:Animals; D001120:Arginine / Q000008:administration & dosage* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage* / Q000494:pharmacology; D009388:Neostigmine / Q000008:administration & dosage* / Q000494:pharmacology; D013552:Swine / Q000502:physiology*
D002800:Cholinesterase Inhibitors; D009388:Neostigmine; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D001120:Arginine