title: [Primary signet-ring-cell carcinoma of the bladder. Description of a case and review of the literature].
abstract: The authors describe a case of infiltrating signet-ring cell carcinoma of the bladder, a rare and extremely aggressive form of adenocarcinoma. This neoplasia in only rarely found in a histologically pure form. In the majority of cases the atypical elements which characterise it are mixed with the gland-like and papillary structures of the adenocarcinoma and with foci of transitional or pavimentous carcinoma. The origin is probably metaplastic. These carcinoma are generally invasive, scarcely differentiated and often cause linitis plastica of the bladder. The histological picture is characterized by atypical epithelial elements with abundant, vacuolised cytoplasma. The nuclei are hyperchromic and eccentric, thus representing the typical appearance of signet-ring cells. The histological picture cannot be distinguished from that of a secondary gastrointestinal or prostatic form, therefore the primary diagnosis requires a full clinical and pathological examination of the sectors describes. The prognosis is severe. Elective therapy consists in radical cystectomy with pelvic lymphadenectomy.
authors.affiliation: Divisione Universitaria di Patologia Urologica, Università degli Studi, Torino.
authors.forename: P
authors.initials: P
authors.lastname: Piana
authors.forename: A
authors.initials: A
authors.lastname: Giammò
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000150:complications / Q000473:pathology* / Q000601:surgery; D015653:Cystectomy; D017809:Fatal Outcome; D006417:Hematuria / Q000209:etiology; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D014547:Urinary Diversion