Neurotrophins in cerebellar granule cell development and medulloblastoma.
Medulloblastomas may be derived from granule cells of the developing cerebellum. Children with tumors expressing high levels of the neurotrophin-3 receptor, TrkC, have a more favorable outcome. During development, TrkC is expressed in the most mature granule cells. Favorable medulloblastomas may be derived from more highly differentiated granule cells.
Pomeroy
S L
SL
Department of Neurology, Children's Hospital, Boston, MA, USA.
Sutton
M E
ME
Goumnerova
L C
LC
Segal
R A
RA
D000818:Animals; D002528:Cerebellar Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D002531:Cerebellum / Q000166:cytology* / Q000254:growth & development*; D003594:Cytoplasmic Granules / Q000187:drug effects; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D009414:Nerve Growth Factors / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis / Q000235:genetics; D020917:Receptor, trkA; D017475:Receptors, Nerve Growth Factor / Q000096:biosynthesis / Q000235:genetics
D009414:Nerve Growth Factors; D011518:Proto-Oncogene Proteins; D017475:Receptors, Nerve Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D020917:Receptor, trkA