title: HLA DQ alpha genotype and allele frequencies in Qatari population.
abstract: Genotype and allele frequencies of HLA DQ alpha locus were determined in a Qatari population sample using polymerase chain reaction (PCR) amplified DNA fragment and hybridization to allele specific oligonucleoid probes in a reversed dot blot format. Among the 200 individuals studied 21 genotypes representing products of 6 HLA DQ alpha alleles have been differentiated, and the frequencies ranged from 0.0775 to 0.2825. The observed and expected genotypes values provide a complete fit to the Hardy-Weinberg equilibrium. The power of discrimination is 0.9321 and chance of paternity exclusion is 60.9% in the Qatari population.
authors.affiliation: Department of Legal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: I M
authors.initials: IM
authors.lastname: Sebetan
authors.forename: H A
authors.initials: HA
authors.lastname: Hajar
mesh_terms: D000483:Alleles; D016172:DNA Fingerprinting / Q000379:methods*; D016002:Discriminant Analysis; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D008877:Middle East / Q000208:ethnology; D016133:Polymerase Chain Reaction / Q000379:methods*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011780:Qatar; D012529:Saudi Arabia / Q000208:ethnology
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen