title: [Pharmacologic intolerance reaction after intravenous injection of pethidine].
abstract: We report on anaphylactoid reactions (urticae at the injection site and along the injection vein) after intravenous injections of pethidine in two patients. Skin tests with pethidine were negative, but intravenous challenge showed urticae. These results indicate that the reactions were due to a non-immunological mechanism resembling pharmacological intolerance. Retrospective analysis revealed a 5.6% incidence of pharmacological intolerance reactions to intravenous pethidine in 519 patients.
authors.affiliation: Abteilung Dermatologie der Universität Ulm.
authors.forename: P
authors.initials: P
authors.lastname: Kühl
authors.forename: A
authors.initials: A
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Winter
authors.forename: H
authors.initials: H
authors.lastname: Gall
mesh_terms: D000759:Adjuvants, Anesthesia / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000707:Anaphylaxis / Q000139:chemically induced*; D000762:Anesthesia Recovery Period; D002648:Child; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008614:Meperidine / Q000009:adverse effects*; D008875:Middle Aged; D012768:Shivering / Q000187:drug effects; D014581:Urticaria / Q000139:chemically induced
chemical_list: D000759:Adjuvants, Anesthesia; D008614:Meperidine