Sucrose as a risk factor for cancer of the colon and rectum: a case-control study in Uruguay.
In order to examine the relationship between dietary sucrose intake and colorectal cancer, a case-control study was conducted in Uruguay in the time period 1992-1996. In all, 289 cases and 564 controls, admitted for diagnosis or treatment in the 4 major hospitals in Montevideo, were considered eligible for the study. Total sucrose intake was associated with a monotonic positive gradient of risks and the odds ratio (OR) for the uppermost quartile of intake was of 2.18 (95% confidence interval, CI, 1.35-3.51). Glucose intake was associated with a small and non-significant increase in risk (OR 1.46, 95% CI 0.76-2.82). Finally, an interaction between sucrose and protein intake was found, and the OR for high intakes of sucrose and protein was 6.07.
De Stefani
E
E
Registro Nacional de Cancer, Instituto Nacional de Oncologia, Montevideo, Uruguay.
Mendilaharsu
M
M
Deneo-Pellegrini
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D019422:Dietary Sucrose / Q000009:adverse effects*; D005260:Female; D005947:Glucose / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors; D014583:Uruguay / Q000453:epidemiology
D019422:Dietary Sucrose; D005947:Glucose