title: Sporadic emergence of Klebsiella pneumoniae strains resistant to cefepime and cefpirome in Greek hospitals.
abstract: The sporadic emergence of Klebsiella pneumoniae strains resistant to cefepime and cefpirome was observed in Greek hospitals during 1996. Examination of six epidemiologically distinct strains and clones selected in vitro provided indications that resistance is due to the cooperation of decreased outer membrane permeability and hydrolysis of the cephalosporins by SHV-5 beta-lactamase, which was produced in large amounts.
authors.affiliation: Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece. LSTBACT@HOTMAIL.COM
authors.forename: L S
authors.initials: LS
authors.lastname: Tzouvelekis
authors.forename: E
authors.initials: E
authors.lastname: Tzelepi
authors.forename: E
authors.initials: E
authors.lastname: Prinarakis
authors.forename: M
authors.initials: M
authors.lastname: Gazouli
authors.forename: A
authors.initials: A
authors.lastname: Katrahoura
authors.forename: P
authors.initials: P
authors.lastname: Giakkoupi
authors.forename: O
authors.initials: O
authors.lastname: Paniara
authors.forename: N J
authors.initials: NJ
authors.lastname: Legakis
mesh_terms: D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D000097572:Cefpirome
chemical_list: D000077723:Cefepime; D002511:Cephalosporins; D000097572:Cefpirome