Interferon treatment for corneolimbal squamous dysplasia.
OBJECTIVE
To report a patient with corneolimbal squamous dysplasia successfully treated with interferon therapy.


METHODS
A 78-year-old man had a gelatinous and vascularized lesion involving the left cornea and adjacent limbus. Impression cytology studied with periodic acid--Schiff-hematoxylin stain disclosed severe squamous dysplasia. Topical instillation and subconjunctival injection of interferon alpha-2b was instituted.


RESULTS
The gelatinous tumor mass involving the cornea and adjacent limbus completely resolved 2 months after interferon treatment. He showed no sign of recurrence during the 10-month follow-up.


CONCLUSIONS
Interferon therapy may be a therapeutic alternative for treating corneolimbal squamous dysplasia.
Hu
F R
FR
Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. fungrong@ha.mc.ntu.edu.tw
Wu
M J
MJ
Kuo
S H
SH
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000473:pathology / Q000628:therapy*; D003316:Corneal Diseases / Q000473:pathology / Q000628:therapy*; D005134:Eye Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007267:Injections; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D016850:Limbus Corneae; D008297:Male; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins