Model-free age-of-onset methods applied to the linkage of bipolar disorder.
We performed Haseman-Elston regression on a set of bipolar pedigrees using each of three dependent variables: a binary trait indicating disease concordance or discordance, a binary trait adjusted for age-of-onset, and the residuals from a survival analysis. The latter two methods, which both adjust for age-of-onset, gave smaller p-values when previous analyses suggested linkage between disease and marker, but not when previous analyses were not suggestive of linkage.
Zhu
X
X
Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, Ohio 44109, USA.
Olson
J M
JM
Schnell
A H
AH
Elston
R C
RC
D017668:Age of Onset; D001714:Bipolar Disorder / Q000235:genetics* / Q000401:mortality; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D016555:Matched-Pair Analysis; D008957:Models, Genetic; D010375:Pedigree; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis; D015996:Survival Rate
D005819:Genetic Markers