title: Age-related mitochondrial DNA deletions: effect of dietary restriction.
abstract: Results from quantitative PCR analysis of the frequency of deleted mitochondrial genomes in male Fischer 344 rats reveal an age-related rise in this molecular abnormality. We used this model to examine the ability of dietary restriction (DR) to prevent this potentially pathogenic change. DR prevented age-related increase in frequency of mitochondrial deletions in the liver. In contrast, however, DR had no effect on the age-related increase in deletion frequency in the brain. These data suggest that the effects of DR on age-related accumulation of mitochondrial DNA deletions may be tissue specific.
authors.affiliation: Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Kang
authors.forename: B S
authors.initials: BS
authors.lastname: Kristal
authors.forename: B P
authors.initials: BP
authors.lastname: Yu
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D002872:Chromosome Deletion; D004272:DNA, Mitochondrial / Q000235:genetics*; D002149:Energy Intake; D016678:Genome; D008297:Male; D016133:Polymerase Chain Reaction; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D004272:DNA, Mitochondrial