title: Accuracy and diagnostic sensitivity of radiographic absorptiometry of the second metacarpal.
abstract: The accuracy of a radiographic absorptiometry (RA) technique called digital image processing (DIP), discriminative ability of RA for osteoporotic fracture, and the relationship between RA and dual X-ray absorptiometry (DXA) of the spine and forearm were evaluated. We measured 16 cadaver hands, 32 healthy non-black premenopausal women, 39 healthy non-black postmenopausal women, and 35 non-black osteoporotic postmenopausal females. The overall correlation between the ash weights of the entire metacarpal and the DIP values was excellent (r = 0.954, P < 0.001, SEE = 0.14, CV = 6.4%). Short-term precision error of DIP was 3.5%. Age-related bone loss determined by DIP is comparable to that of spinal and forearm DXA: annual BMD decreases were 0.46% for DIP, 0.45% for forearm, and 0.32% for the spine. DIP of the 2nd metacarpal shows a gradient of risk for spinal fracture only slightly below that of forearm DXA, but substantially below that of spinal DXA. Age-adjusted odds ratios were 1.81 for RA, 2.45 for spinal DXA, and 1.94 for forearm DXA.
authors.affiliation: Department of Radiology, University of California San Francisco, 94143-0628, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hagiwara
authors.forename: K
authors.initials: K
authors.lastname: Engelke
authors.forename: M
authors.initials: M
authors.lastname: Takada
authors.forename: S O
authors.initials: SO
authors.lastname: Yang
authors.forename: S
authors.initials: S
authors.lastname: Grampp
authors.forename: M S
authors.initials: MS
authors.lastname: Dhillon
authors.forename: H K
authors.initials: HK
authors.lastname: Genant
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008663:Metacarpus / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D016103:Spinal Fractures / Q000000981:diagnostic imaging