title: The role of mucosal biopsy in the diagnosis of chronic diarrhea: value of multiple biopsies when colonoscopic finding is normal or nonspecific.
abstract: OBJECTIVE
  There are controversies about taking routine mucosal biopsy when the gross colonoscopic finding is normal. This study was conducted to determine the frequency of clinically important histological abnormalities, prospectively, in chronic diarrhea patients with grossly normal or nonspecific colonoscopic findings.
  
  
  METHODS
  One hundred and eighteen patients suffering from nonbloody diarrhea with average frequency of more than two times a day for more than 4 weeks were included. Multiple biopsies (cecum, ascending colon, mid-transverse colon, descending colon, sigmoid colon and rectum) were taken during colonoscopic examinations and each biopsy specimen was reviewed by one pathologist after H&E and Masson-trichrome staining.
  
  
  RESULTS
  Clinically significant abnormalities (2 collagenous colitis, 1 lymphocytic colitis, 1 eosinophilic enterocolitis, 1 ulcerative colitis and 4 melanosis coli) were observed in 9 patients (7.6%). Sixteen cases (13.6%) of borderline histological abnormalities were observed (8 cases of possible collagenous colitis and 8 cases showing some features of lymphocytic colitis). Ninety two cases (78.8%) showed nonspecific inflammation only.
  
  
  CONCLUSIONS
  Clinically important histological lesions can exist in significant percentage in spite of normal or nonspecific colonoscopic findings, which can justify routine mucosal biopsy in the evaluation of chronic diarrhea patients. The clinical significance of borderline histological abnormalities needs to be determined by careful follow-up studies.
authors.affiliation: Department of Medicine, Sung Kyun Kwan University College of Medicine, Samsung medical Center, Seoul, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: P L
authors.initials: PL
authors.lastname: Rhee
authors.forename: J J
authors.initials: JJ
authors.lastname: Kim
authors.forename: K C
authors.initials: KC
authors.lastname: Koh
authors.forename: S W
authors.initials: SW
authors.lastname: Paik
authors.forename: J H
authors.initials: JH
authors.lastname: Han
authors.forename: H J
authors.initials: HJ
authors.lastname: Ree
authors.forename: J C
authors.initials: JC
authors.lastname: Rhee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002908:Chronic Disease; D003106:Colon / Q000473:pathology*; D003113:Colonoscopy; D003967:Diarrhea / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies