[Survival after poisoning due to intake of ten-times lethal dose of acetone].
METHODS
A 42-year-old man was found unconscious, having swallowed 800 ml of an unknown liquid with suicidal intent. On admission, when his breath smelled strongly of acetone, he was intubated and ventilated, and several gastric lavages were performed.


METHODS
The serum acetone concentration was 2000 mg/l, that in urine 2300 mg/l. The residue of the liquid in the bottle from which he had drunk was pure acetone.


METHODS
Acetone poisoning having been established he was carefully hyperventilated, haemofiltration was performed over 16 hours and forced diuresis with high fluid intake was undertaken. His condition quickly improved and he was extubated after 14 hours. There was no subsequent evidence of organ damage. Repeated measurements of acetone in blood and urine indicated its elimination with a half-life of 11 hours. Literature search revealed that this was the second highest concentration of acetone in blood and urine followed by survival.


CONCLUSIONS
This case demonstrates that, after acute acetone poisoning with an amount ten times the lethal dose, intensive care and rapid elimination of acetone can achieve sequelae-free survival.
Zettinig
G
G
Klinische Abteilung für Kardiologie, Medizinischen Universitätsklinik Graz.
Watzinger
N
N
Eber
B
B
Henning
G
G
Klein
W
W
D000096:Acetone / Q000097:blood / Q000506:poisoning* / Q000652:urine; D000328:Adult; D004231:Diuresis; D005751:Gastric Lavage; D006440:Hemofiltration; D006801:Humans; D008297:Male; D011041:Poisoning / Q000401:mortality / Q000628:therapy*; D012121:Respiration, Artificial; D013997:Time Factors
D000096:Acetone