Sheep pulmonary adenomatosis: a unique model of retrovirus-associated lung cancer.
Sheep pulmonary adenomatosis (SPA) is a contagious bronchiolo-alveolar carcinoma of sheep associated with an exogenous type D/B retrovirus known as jaagsiekte sheep retrovirus (JSRV). SPA represents a unique model for lung cancer, and studies on its aetiopathogenesis can provide further insight into the mechanisms of epithelial neoplasms.
Palmarini
M
M
Cancer Research Institute, University of California Irvine 92697, USA. massimo@darwin.bio.uci.edu
Fan
H
H
Sharp
J M
JM
D000818:Animals; D030121:Betaretrovirus / Q000235:genetics / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology / Q000821:virology*; D011648:Pulmonary Adenomatosis, Ovine / Q000503:physiopathology / Q000821:virology*; D012106:Research; D012756:Sheep; D014779:Virus Replication