title: [Waiting for the crisis].
abstract: OBJECTIVE
  Experience in daily routine reveals that most of ICU patients usually go through "crisis" within 14 days of admission. Only few patients need remarkable more time to get to this point and it seems there is hardly anything to be done therapeutically to change the course of it. We therefore examined a large group of ICU patients in order to find reasons for this course or to spot them as an "entity of their own".
  
  
  METHODS
  1,861 ICU patients all being on IPPV for more than three days were included in the study. Every day 18 variables were taken down in a standardised way until the day IPPV was finished. We extracted 170 patients who were artificially ventilated for more than 40 days. For these patients we established mean values for each of the 18 variables during the first and the last 40 days of ventilation. In both groups we compared survivors to non-survivors.
  
  
  RESULTS
  Mortality was almost the same in both groups (IPPV < 40 days vs. IPPV > 40 days). Survivors and non-survivors showed remarkable differences regarding extrapulmonary factors-in terms of total fluid amount and transfusion, state of abdomen, brain, liver and kidney function and circulation problems. Pulmonary factors revealed major differences only towards the end of the observation period.
  
  
  CONCLUSIONS
  There seems to be an "entity of ist own", a small population of patients who arrive at the crucial turning point later. Pulmonary complications (pneumonia, ARDS) is not the reason but the expression of cause for prolonged ventilation. The key to the extrapulmonary origin of the crisis remains unknown, the only thing we can do is alleviate its manifestations.
authors.affiliation: II. Lehrstuhl für Chirurgie, Universität Köln.
authors.forename: G D
authors.initials: GD
authors.lastname: Giebel
authors.forename: M
authors.initials: M
authors.lastname: Doehn
authors.forename: M
authors.initials: M
authors.lastname: Müller-Gorges
authors.forename: R
authors.initials: R
authors.lastname: Stuttmann
mesh_terms: D002423:Cause of Death; D003422:Critical Care / Q000706:statistics & numerical data*; D003428:Cross Infection / Q000401:mortality; D018450:Disease Progression; D017052:Hospital Mortality; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009104:Multiple Trauma / Q000401:mortality; D011183:Postoperative Complications / Q000401:mortality; D012128:Respiratory Distress Syndrome / Q000401:mortality; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome