[Evaluation of the usefulness of the liver for transplantation based on 26 multiorgan harvests].
This study is aimed at the clinical and morphological criteria of estimation of the liver harvested for transplantation. In the period from January 1996 to May 1997 our team obtained 26 livers at the multi-organ harvesting. Most of the donors were young people after the trauma of central nervous system. The liver was harvested according to the principles of Starzl's fast method with the successive preparation on the "cold table". The donor's clinical status was estimated, as well as appearance, density and colour of the organ, quality of perfusion with UW solution In 23 cases the histological examination of the harvested organ allowed to estimate the degree of steatosis, hepatocyte necrosis, vacuolar degeneration and other abnormalities. In 3 cases the graft was estimated only by means of macroscopic examination.


RESULTS
As a result of clinical and histological findings 8 organs were considered as unsuitable for transplantation. In one case the histological findings were the contraindication despite the satisfactory macroscopic appearance of the organ 15 organs were successfully transplanted, proving the conformity of clinical and histological criteria. In 4 livers (15%) the abnormalities of arterial supply were found.


CONCLUSIONS
Clinical and pathomorphological estimation of the harvested liver is adequate to it's suitability for transplantation, advisable for the centres initiating the liver transplantation program. Detailed analysis of the donor's clinical status and laboratory data and competent macroscopic estimation of the harvested liver allow the experienced surgeon to resign from the routine histological verification, which might be necessary in doubtful cases only.
Małkowski
P
P
Katedry i Kliniki Chirurgii Ogólnej i Chorób Watroby, Akademii Medycznej w Warszawie.
Pawlak
J
J
Grzelak
I
I
Nyckowski
P
P
Zieniewicz
K
K
Wrzaszczyk
R
R
Wróblewski
T
T
Paluszkiewicz
R
R
Otto
W
W
Alsharabi
A
A
Patkowski
W
W
Schaeffer
M
M
Gackowski
W
W
Maagam
S
S
D006801:Humans; D008099:Liver / Q000166:cytology*; D009926:Organ Preservation; D016377:Organ Transplantation / Q000592:standards*; D011786:Quality Control; D014019:Tissue Donors; D014021:Tissue Preservation / Q000379:methods; D009927:Tissue and Organ Procurement / Q000592:standards*