[The use of antisense oligonucleotides for modulation of cytokine gene expression].
The review summarizes literature data on the mechanism of action and the use of antisence oligonucleotides for modulation of cytokine gene expression in haemo- and immunopoesis. This new approach for gene-directed modulation of the gene expression allows to analyze both intercellular and intracellular protein interaction. Use of this approach is prospective for both experimental researches in vivo and in vitro and application in therapeutic purposes.
Kozlov
V A
VA
Sennikov
S V
SV
D000818:Animals; D000917:Antibody Formation / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000276:immunology; D005786:Gene Expression Regulation; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000276:immunology; D016376:Oligonucleotides, Antisense / Q000097:blood / Q000235:genetics* / Q000276:immunology
D016207:Cytokines; D016376:Oligonucleotides, Antisense