Generalized pustular psoriasis responsive to PUVA and oral cyclosporin therapy.
A patient with acute generalized pustular psoriasis was successfully treated with a combination of oral cyclosporin (6 mg/kg per day) and photochemotherapy (PUVA). Although early inpatient treatment with weak topical steroids and PUVA produced initial improvement, the patient's clinical condition fluctuated, with the subsequent development of erythroderma. The addition of oral cyclosporin produced dramatic improvement within 1 week of its commencement. The patient remained in remission 12 months following cessation of therapy.
Hunt
M J
MJ
Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Lee
S H
SH
Salisbury
E L
EL
Wills
E J
EJ
Armati
R
R
D000208:Acute Disease; D000284:Administration, Oral; D001707:Biopsy, Needle; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008730:Methoxsalen / Q000008:administration & dosage*; D008875:Middle Aged; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D008730:Methoxsalen