title: Alzheimer's disease. A technical KO of amyloid-beta peptide.
authors.forename: C
authors.initials: C
authors.lastname: Haass
authors.forename: D J
authors.initials: DJ
authors.lastname: Selkoe
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D001692:Biological Transport; D022762:CCAAT-Enhancer-Binding Proteins; D002462:Cell Membrane / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D009154:Mutation; D009687:Nuclear Proteins / Q000378:metabolism; D053764:Presenilin-1; D011499:Protein Processing, Post-Translational; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors
chemical_list: D016564:Amyloid beta-Protein Precursor; D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; C497387:SREBF1 protein, human; C102196:SREBP cleavage-activating protein; C497388:Srebf1 protein, mouse; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse