Hepatitis C virus genotypes implicated in mixed cryoglobulinemia.
Recent reports suggest that hepatitis C virus (HCV) might be a causative agent of mixed cryoglobulinemia. To determine whether the HCV genotype is a factor implicated in the onset of cryoglobulinemia, genotyping by direct sequencing of polymerase chain reaction products of the 5' non coding region was carried out among 45 HCV-infected patients. Genotypes 1 and 2 were found more prevalent in symptomatic cryoglobulinemia patients. Due to the presence of genotypes 4 and 5 found in this panel of French patients (9.3%), HCV genotyping based on sequence determination is recommended.
Nguyen
Q T
QT
Laboratoire de Bactériologie-Virologie, Hôpital Avicenne, Bobigny, France.
Leruez-Ville
M
M
Ferrière
F
F
Cohen
P
P
Roulot-Marullo
D
D
Coste
T
T
Dény
P
P
Guillevin
L
L
D016022:Case-Control Studies; D003449:Cryoglobulinemia / Q000821:virology*; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics; D014158:Transcription, Genetic
D012367:RNA, Viral