title: Oral absorption tests: absorption site of each substrate.
abstract: Three oral absorption tests have been used in patients with short bowel syndrome (SBS) to evaluate the absorption site of each substrate. In this study, three absorption tests were applied: the oral pancreatic function test using N-benzoyl-L-tyrosyl-p-aminobenzoic acid (NBT-PABA), the D-xylose tolerance test, and the oral fat tolerance test. Examinations were performed in eight patients with either a duodenostomy or a jejunostomy located less than 60 cm from the ligament of Treitz, and in a patient with an end ileostomy. Forty-six healthy volunteers participated as controls for the oral fat tolerance test. PABA and D-xylose concentrations were measured in urine. The serum triacylglycerol concentration was determined at 0, 1, 2, and 3 h after ingestion. All eight patients with SBS demonstrated pathologic absorption on each test. We conclude that small bowel integrity is critical for evaluation of the NBT-PABA test. We also determined that the duodenum and proximal jejunum do not play an important role in the absorption of D-xylose and triacylglycerol. We could also evaluate limitations and advantages of the other kinds of oral absorption tests and nutrients through patients with SBS.
authors.affiliation: Department of Surgery II, Yamaguchi University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ueno
authors.forename: Y
authors.initials: Y
authors.lastname: Hamanaka
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D010129:4-Aminobenzoic Acid / Q000652:urine; D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D004041:Dietary Fats / Q000008:administration & dosage; D004385:Duodenostomy; D004386:Duodenum / Q000378:metabolism; D005260:Female; D006801:Humans; D007081:Ileostomy; D007408:Intestinal Absorption; D007582:Jejunostomy; D007583:Jejunum / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012778:Short Bowel Syndrome / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D014994:Xylose / Q000652:urine
chemical_list: D004041:Dietary Fats; D014280:Triglycerides; D014994:Xylose; D010129:4-Aminobenzoic Acid