title: Beta-blockers in heart failure--a cardioprotective therapy?
abstract: Heart failure remains a major cause of morbidity and mortality despite optimum treatment with angiotensin-converting enzyme inhibitors and diuretics. Meta-analysis of recent placebo-controlled, randomized trials suggest that treatment with beta-blockers may significantly reduce mortality by 35%.
authors.affiliation: Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, U.K.
authors.forename: M J
authors.initials: MJ
authors.lastname: Landray
authors.forename: M J
authors.initials: MJ
authors.lastname: Kendall
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D015536:Down-Regulation; D005500:Follow-Up Studies; D006333:Heart Failure / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors