title: Therapeutic effects of water-soluble echinocandin compounds on Pneumocystis pneumonia in mice.
abstract: The therapeutic effectiveness of water-soluble echinocandin compounds obtained from Coleophoma empetri F-11899, which has a strong inhibitory effect on the growth of fungi, was examined in nude mice with experimental Pneumocystis pneumonia. The studies demonstrated the potential usefulness of the compounds.
authors.affiliation: Department of Parasitology, The Institute of Medical Science, The University of Tokyo, Japan. furuta@hgc.ims.u-tokyo.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Furuta
authors.forename: H
authors.initials: H
authors.lastname: Muramatsu
authors.forename: A
authors.initials: A
authors.lastname: Fujie
authors.forename: S
authors.initials: S
authors.lastname: Fujihira
authors.forename: N R
authors.initials: NR
authors.lastname: Abudullah
authors.forename: S
authors.initials: S
authors.lastname: Kojima
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry / Q000627:therapeutic use*; D011010:Pneumocystis / Q000187:drug effects* / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D051381:Rats
chemical_list: C110369:FR 131535; C110368:FR 901379; D010456:Peptides, Cyclic