[P21-ras protein in tumors of the large intestine].
We carried out a prospective analysis of cytoplasmatic accumulation of p21ras protein-a Ki-ras gene product. The study was completed on the group of 80 patients with sporadic colorectal cancer. p21ras protein was detected immunohistochemically with use of NCC-001 antibody. In 64/80 cases (80%) we found p21ras protein accumulation in the tumor. We found that the protein accumulation is present more often in poorly differentiated cancers 91.3% (42/46) than in well and intermediate differentiated 64.7% (22/34) and in the right side of the colon 100% (14/14) than in left side colon 53.3% (14/24). The differences were statistically significant (p < 0.05). We found no statistically significant differences in survival time after surgery in correlation with p21ras accumulation in tumor. Our result suggest that p21ras accumulation is not a solitary prognostic factor in sporadic colorectal cancer.
Pawłowska-Wakowicz
B
B
Pracowni Histopatologicznej, Wojewódzkiego Szpitala Zespolonego im. Jana Boźego w Lublinie.
Paluszkiewicz
P
P
Karski
J
J
Wojcierowski
J
J
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D003593:Cytoplasm / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011446:Prospective Studies; D016283:Proto-Oncogene Proteins p21(ras) / Q000032:analysis*; D015996:Survival Rate
D014408:Biomarkers, Tumor; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)