title: Accuracy of a cerebral oximeter in healthy volunteers under conditions of isocapnic hypoxia.
abstract: BACKGROUND
  A cerebral oximeter measures oxygen saturation of brain tissue noninvasively by near infrared spectroscopy. The accuracy of a commercially available oximeter was tested in healthy volunteers by precisely controlling end-tidal oxygen (P[ET]O2) and carbon dioxide (P[ET]CO2) tensions to alter global cerebral oxygen saturation.
  
  
  METHODS
  In 30 healthy volunteers, dynamic end-tidal forcing was used to produce step changes in P[ET]O2 resulting in arterial saturation ranging from approximately 70% to 100% under conditions of controlled normocapnia (each person's resting P[ET]CO2) or hypercapnia (resting plus 7-10 mmHg). Blood arterial (SaO2) and jugular bulb venous (S[jv]O2) saturations during each P(ET)O2 interval were determined by co-oximetry. The cerebral oximeter reading (rSO2) and an estimated jugular venous saturation (S[jv]O2), derived from a combination of SaO2 and rSO2, were compared with the measured S(jv)O2.
  
  
  RESULTS
  The S(jv)O2 was significantly higher with hypercapnia than with normocapnia for the same SaO2. The rSO2 and S(jv)O2 were both highly correlated with S(jv)O2 for individual volunteers (mean r2 = 0.91 for each relation); however, the slopes and intercepts varied widely among volunteers. In three of them, the cerebral oximeter substantially underestimated the measured S(jv)O2.
  
  
  CONCLUSIONS
  During isocapnic hypoxia in healthy persons, cerebral oxygenation as estimated by near infrared spectroscopy precisely tracks changes in measured S(jv)O2 within individuals, but the relation exhibits a wide range of slopes and intercepts. Therefore the clinical utility of the device is limited to situations in which tracking trends in cerebral oxygenation would be acceptable.
authors.affiliation: Department of Anesthesiology, University of Rochester School of Medicine, New York 14642, USA. lhenson@anes.rochester.edu
authors.forename: L C
authors.initials: LC
authors.lastname: Henson
authors.forename: C
authors.initials: C
authors.lastname: Calalang
authors.forename: J A
authors.initials: JA
authors.lastname: Temp
authors.forename: D S
authors.initials: DS
authors.lastname: Ward
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood; D008297:Male; D010092:Oximetry; D011187:Posture
chemical_list: D002245:Carbon Dioxide