title: Antioxidative compounds isolated from safflower (Carthamus tinctorius L.) oil cake.
abstract: Seven antioxidative serotonin derivatives were isolated from safflower (Carthamus tinctorius L.) oil cake. Their structures were established as N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]ferulamide (1), N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-p-coumaramide (2), N,N'-[2,2'-(5,5'-dihydroxy-4,4'-bi-1H-indol-3,3'-yl)diethyl]- di-p-coumaramide (3), N-[2-[3'-[2-(p-coumaramido)ethyl]-5,5'-dihydroxy- 4,4'-bi-1H-indol-3-yl]ethyl]ferulamide (4), and N,N'-[2,2'-(5,5'-dihydroxy-4,4'-bi-1H-indol-3,3'-yl)diethyl]- diferulamide (5), N-[2-[5-(beta-D-glucosyloxy)-1H-indol-3-yl)ethyl]- p-coumaramide (6), and N-[2-[5-(beta-D-glucosyloxy)-1H-indol-3-yl)ethyl]ferulamide (7). Antioxidative activities of the compounds were measured by the ferric thiocyanate method and the alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) method, and compounds 1-5 were found to have relatively strong antioxidative activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: H L
authors.initials: HL
authors.lastname: Zhang
authors.forename: A
authors.initials: A
authors.lastname: Nagatsu
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: J
authors.initials: J
authors.lastname: Sakakibara
authors.forename: H
authors.initials: H
authors.lastname: Okuyama
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D015764:Bepridil / Q000031:analogs & derivatives; D001713:Biphenyl Compounds; D003373:Coumaric Acids / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification*; D007202:Indicators and Reagents; D007501:Iron; D009682:Magnetic Resonance Spectroscopy; D010851:Picrates; D011422:Propionates; D012450:Safflower Oil / Q000737:chemistry*; D012701:Serotonin / Q000031:analogs & derivatives*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013861:Thiocyanates
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D003373:Coumaric Acids; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D010851:Picrates; D011422:Propionates; D013861:Thiocyanates; D012701:Serotonin; C103724:ferric thiocyanate; D015764:Bepridil; D012450:Safflower Oil; C004999:ferulic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron; C495469:p-coumaric acid