title: Inappropriate sinus tachycardia after radiofrequency ablation of para-Hisian accessory pathways.
abstract: BACKGROUND
  Inappropriate sinus tachycardia (IST) has been observed following radiofrequency ablation (RFA) of the AV nodal fast pathway. This study was aimed to prospectively analyze the incidence and clinical significance of IST following RFA of para-Hisian accessory pathways (APs).
  
  
  RESULTS
  Twenty-eight patients (pts) with para-Hisian APs underwent RFA. An AP was defined as para-Hisian whenever its atrial and ventricular insertions were associated with a His-bundle potential > or = 0.1 mV. RF current was always delivered at the atrial aspect of the tricuspid annulus, to a site where the His-bundle potential was < 0.15 mV. Time- and frequency-domain analysis of heart rate variability was performed in 22 patients, before and after RFA. Abolition of AP conduction was obtained in all pts, and no AV conduction alteration occurred. Six pts (21.4%) presented with IST 45 to 240 minutes after the ablation procedure. In 5 of them, IST disappeared spontaneously within 72 hours, whereas in 1 pt beta-blockers were required for 2 months. The atrial potential amplitude (1.217 +/- 0.264 mV vs 0.882 +/- 0.173 mV, P = 0.009) and A/V potential amplitude ratio (2.633 vs 1.686, P = 0.05) were significantly higher in pts who developed IST than in those who did not. A marked decrease in heart rate variability was observed only in pts who developed IST.
  
  
  CONCLUSIONS
  IST is a relatively frequent complication after RFA of para-Hisian APs: it is generally short-lasting and usually does not require any treatment. IST after catheter ablation is likely to depend upon transient parasympathetic denervation of the sinus node.
authors.affiliation: Cardiology Department, Hospital San Raffaele, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pappone
authors.forename: G
authors.initials: G
authors.lastname: Stabile
authors.forename: G
authors.initials: G
authors.lastname: Oreto
authors.forename: A
authors.initials: A
authors.lastname: De Simone
authors.forename: M
authors.initials: M
authors.lastname: Rillo
authors.forename: P
authors.initials: P
authors.lastname: Mazzone
authors.forename: R
authors.initials: R
authors.lastname: Cappato
authors.forename: S
authors.initials: S
authors.lastname: Chierchia
mesh_terms: D000293:Adolescent; D000328:Adult; D001283:Atrioventricular Node / Q000503:physiopathology; D017115:Catheter Ablation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D013616:Tachycardia, Sinus / Q000209:etiology*; D014927:Wolff-Parkinson-White Syndrome / Q000601:surgery*