Structure of the multidrug resistance P-glycoprotein.
In order to elucidate the mechanism by which the multidrug resistance P-glycoprotein extrudes cytotoxic drugs from the cell, and particularly the number and nature of the drug binding site(s), knowledge of the structure of P-gp is essential. A considerable body of genetic and biochemical data has accrued which gives insights into P-gp structure and function. These data are critically reviewed, particularly in relation to the low resolution structure of P-gp which has recently been determined by electron microscopy. P-gp is one of the best characterised of the ABC transporters and these structure-function studies may have more general implications.
Higgins
C F
CF
Nuffield Department of Clinical Biochemistry, University of Oxford, John Radcliffe Hospital, UK.
Callaghan
R
R
Linton
K J
KJ
Rosenberg
M F
MF
Ford
R C
RC
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D011487:Protein Conformation; D017434:Protein Structure, Tertiary
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1