Prevention of transmission. Pharmaceutical and obstetric approaches.
An increasing body of information regarding risk factors for perinatal HIV transmission suggests the use of logical management strategies during the prenatal period and parturition directed at maximizing maternal health and minimizing perinatal transmission. This article reviews the recommendations for pharmacologic therapy and rational obstetric management strategies to decrease perinatal HIV transmission based on published clinical trials and a review of data relevant to transmission.
Tuomala
R E
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Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D036861:Delivery, Obstetric / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D015215:Zidovudine / Q000627:therapeutic use*
D019380:Anti-HIV Agents; D015215:Zidovudine