title: Biochemical alterations in neonatal hypoxic ischaemic brain damage.
abstract: Asphyxiated (n = 39) and control (n = 23) were elected for the study. Free radical-mediated lipid peroxidation, prostaglandin E2 and vitamin E levels were studied and the degree of hypoxic ischaemic encephalopathy was determined in each case. In the hypoxic group the concentration of prostaglandin E2 activity (P < 0.05) and malondialdehyde levels (P < 0.01) were significantly higher when compared to that of controls. The high vitamin E concentrations in the asphyxiated infants supports the role of oxygen free radicals in hypoxic ischaemic encephalopathy of newborns.
authors.affiliation: Gazi University Medical Faculty, Department of Pediatric Neurology, Ankara, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Gücüyener
authors.forename: T
authors.initials: T
authors.lastname: Gür
authors.forename: E
authors.initials: E
authors.lastname: Oz
authors.forename: C
authors.initials: C
authors.lastname: Türkyilmaz
authors.forename: G
authors.initials: G
authors.lastname: Oztürk
authors.forename: D
authors.initials: D
authors.lastname: Erbaş
authors.forename: Y
authors.initials: Y
authors.lastname: Atalay
authors.forename: A
authors.initials: A
authors.lastname: Hasanoğlu
mesh_terms: D001238:Asphyxia Neonatorum / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D015232:Dinoprostone / Q000097:blood / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000378:metabolism*; D014810:Vitamin E / Q000097:blood / Q000378:metabolism*
chemical_list: D014810:Vitamin E; D008315:Malondialdehyde; D015232:Dinoprostone