title: Magnetic resonance spectroscopy of isoflurane kinetics in humans. Part II: Functional localization.
abstract: We describe the first experiments to relate the cerebral kinetics of isoflurane (determined by fluorine magnetic resonance spectroscopy) to cerebral function. Using a surface receive coil we found two-compartment kinetics within the head with equilibrium half-times of 3.5 min and approximately 1 h with respect to expired isoflurane concentrations. Using critical fusion flicker frequency as an objective measure of the cerebral effect of isoflurane, we found evidence to identify the fast component as the brain. Responsiveness to command was lost at a brain partial pressure of 0.3% isoflurane. We conclude that the measured cerebral kinetics of isoflurane exactly matched the predictions of the classical perfusion-limited model.
authors.affiliation: Department of Anaesthesia, Hammersmith Hospital, London.
authors.forename: G G
authors.initials: GG
authors.lastname: Lockwood
authors.forename: D P
authors.initials: DP
authors.lastname: Dob
authors.forename: D J
authors.initials: DJ
authors.lastname: Bryant
authors.forename: J A
authors.initials: JA
authors.lastname: Wilson
authors.forename: J
authors.initials: J
authors.lastname: Sargentoni
authors.forename: S M
authors.initials: SM
authors.lastname: Sapsed-Byrne
authors.forename: D N
authors.initials: DN
authors.lastname: Harris
authors.forename: D K
authors.initials: DK
authors.lastname: Menon
mesh_terms: D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism*; D003198:Computer Simulation; D005425:Flicker Fusion / Q000187:drug effects*; D006801:Humans; D007530:Isoflurane / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D010313:Partial Pressure
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane