Sequence, structure, and chromosomal mapping of the mouse Lgals6 gene, encoding galectin-6.
In the accompanying paper (Gitt, M. A., Colnot, C., Poirier, F., and Barondes, S. H., and Leffler, H. (1998) J. Biol. Chem. 273, 2954-2960), we reported that mouse gastrointestinal tract specifically expresses two closely related galectins, galectins-4 and -6, each with two carbohydrate recognition domains in the same peptide. Here, we report the isolation, characterization, and chromosomal mapping of the complete mouse Lgals6 gene, which encodes galectin-6, and of a fragment of a distinct gene, Lgals4, which encodes galectin-4. The coding sequence of galectin-6 is specified by eight exons. The upstream region contains two putative promoters. Both Lgals6 and the closely related Lgals4 are clustered together about 3.2 centimorgans proximal to the apoE gene on mouse chromosome 7. The syntenic human region is 19q13.1-13.3.
Gitt
M A
MA
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California, San Francisco, California 94143-0984, USA.
Xia
Y R
YR
Atchison
R E
RE
Lusis
A J
AJ
Barondes
S H
SH
Leffler
H
H
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004064:Digestive System / Q000378:metabolism*; D005091:Exons; D037541:Galectin 4; D037161:Galectins; D006388:Hemagglutinins / Q000235:genetics; D007438:Introns; D037102:Lectins / Q000737:chemistry* / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D001057:Apolipoproteins E; D037541:Galectin 4; D037161:Galectins; D006388:Hemagglutinins; D037102:Lectins; C110383:Lgals6 protein, mouse