Post immunization Hib antigen detection in the CSF of a patient with meningococcal meningitis.
We report a case of meningococcal meningitis where the cerebrospinal fluid was negative for Neisseria meningitidis but positive for Haemophilus influenzae type b by rapid antigen detection test. We believe that this was due to prior immunization with Haemophilus influenzae type b vaccine. We recommend caution in interpretation of the rapid antigen detection tests especially in patients who had been vaccinated against organisms screened by these tests.
Samaha
A N
AN
Department of Pediatrics, American University of Beirut, Lebanon.
Araj
G F
GF
Mroueh
S M
SM
D000942:Antigens, Bacterial / Q000134:cerebrospinal fluid*; D002443:Ceftriaxone / Q000008:administration & dosage; D002511:Cephalosporins / Q000008:administration & dosage; D002555:Cerebrospinal Fluid / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D018073:Haemophilus Vaccines / Q000276:immunology*; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D007223:Infant; D007841:Latex Fixation Tests; D008585:Meningitis, Meningococcal / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000188:drug therapy; D009345:Neisseria meningitidis / Q000302:isolation & purification; D013997:Time Factors; D014611:Vaccination
D000942:Antigens, Bacterial; D002511:Cephalosporins; D018073:Haemophilus Vaccines; D002443:Ceftriaxone