title: The efficacy of ANSAID (flurbiprofen) as an analgesic in foot surgery.
abstract: Eighty-three patients scheduled for outpatient surgery were enrolled in this double-blind, randomized trial designed to compare the safety and efficacy of single and multiple doses of flurbiprofen 50 mg. and acetaminophen 300 mg. plus codeine phosphate 30 mg. During the multiple dose segment, statistically significant differences were observed during the first 24 hour postoperative period regarding relief of pain and pain intensity. Flurbiprofen provided greater relief of pain than the acetaminophen with codeine phosphate combination. This study supports the use of flurbiprofen as a suitable alternative to acetaminophen plus codeine phosphate in the treatment of postoperative pain following foot surgery.
authors.affiliation: Upjohn Company: Pharmacia & Upjohn, Kalamazoo, MI, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Soulier
authors.forename: J C
authors.initials: JC
authors.lastname: Page
authors.forename: L C
authors.initials: LC
authors.lastname: Larsen
authors.forename: B C
authors.initials: BC
authors.lastname: Grose
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003061:Codeine / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations; D005480:Flurbiprofen / Q000627:therapeutic use*; D005528:Foot / Q000601:surgery*; D006801:Humans; D010149:Postoperative Pain / Q000188:drug therapy*
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D000082:Acetaminophen; D005480:Flurbiprofen; D003061:Codeine