title: Leydig cell tumor--comparison of results of radical and testis-sparing surgery in a single center.
abstract: Between January 1981 and December 1995, 15 patients were treated for Leydig cell tumor at our institution -- 12 by radical orchiectomy, 3 by tumor enucleation. All patients were contacted to assess the long-term outcome depending on the treatment initially chosen. Follow-up ranged from 8 to 161 months (mean 56). In no case was progressive disease documented, in 1 case local recurrence was witnessed 4 months after tumor enucleation despite negative resection margins. We conclude that a small Leydig cell tumor can safely be managed by local enucleation alone.
authors.affiliation: Department of Urology, Benjamin Franklin Medical Center, Free University School of Medicine, Berlin, Germany.
authors.forename: H E
authors.initials: HE
authors.lastname: Wegner
authors.forename: K P
authors.initials: KP
authors.lastname: Dieckmann
authors.forename: H
authors.initials: H
authors.lastname: Herbst
authors.forename: R
authors.initials: R
authors.lastname: Andresen
authors.forename: K
authors.initials: K
authors.lastname: Miller
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism; D005500:Follow-Up Studies; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007984:Leydig Cell Tumor / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009919:Orchiectomy; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human; D012739:Gonadal Steroid Hormones; D000509:alpha-Fetoproteins; D007770:L-Lactate Dehydrogenase