Detection of immunoreactive parathyroid hormone-related protein in human cerebrospinal fluid.
Immunoreactive parathyroid hormone-related protein (PTH-rP) was measured in simultaneously obtained cerebrospinal fluid (CSF) and plasma from 51 patients suspected of suffering from a prolapsed intervertebral disc. Endocrine or psychiatric diseases were excluded. In addition, immunoreactive parathyroid hormone (PTH) in the CSF samples was measured. Both, PTH-rP and PTH were assayed by immunoradiometric assay. The results indicate the presence of both, PTH-rP and PTH in CSF. The following concentrations (mean values +/- SD) were found: PTH-rP (pmol/l) in CSF without pleocytosis (n = 17) 0.432 +/- 0.157, with pleocytosis (n = 34) 0.654 +/- 0.675; in plasma (pmol/l) 54.1 +/- 14.632; PTH (nmol/l) in CSF without pleocytosis (n = 17) 0.454 +/- 0.099, with pleocytosis (n = 34) 0.437 +/- 0.140, and in plasma 4.272 +/- 0.794. The concentrations of both, PTH-rP and PTH, in CSF with and without pleocytosis were not significantly different. No correlation was found between PTH-rP and PTH values. The present study demonstrated PTH-rP as a normal constituent in human CSF.
Bühler
G
G
Section Pharmacotherapy, University of Ulm, Germany.
Balabanova
S
S
Milowski
S
S
Rosenthal
J
J
Antoniadis
G
G
Mohr
K
K
Richter
H P
HP
D000293:Adolescent; D000328:Adult; D000368:Aged; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D006801:Humans; D007403:Intervertebral Disc; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000134:cerebrospinal fluid; D044162:Parathyroid Hormone-Related Protein; D011391:Prolapse; D011506:Proteins / Q000032:analysis*; D012016:Reference Values; D013122:Spinal Diseases / Q000134:cerebrospinal fluid
C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins