title: Differential effects of neuropeptide Y type 2 receptor activation on responses of rat ventral posteromedial thalamus neurons to surround vibrissae and trigeminal subnucleus interpolaris stimulation.
abstract: Single cell recording, receptive field analysis, and microejection techniques were used to evaluate the effects of neuropeptide Y (NPY) type 2 (Y2) receptor activation on the responses of vibrissae-sensitive ventral posteromedial thalamic (VPM) neurons. Activation of this receptor with the C-terminal fragment, NPY[13-36] had no significant effect on responses evoked by deflection of principal or surround vibrissae or electrical stimulation of the trigeminal principal sensory nucleus. However, it did significantly decrease (p < 0.01) responses evoked by electrical stimulation of subnucleus interpolaris (SpI) by a mean (+/- standard error) of -31.0 +/- 8.7%). The finding that responses to surround vibrissa stimulation were not significantly decreased by a manipulation that did significantly attenuate SpI- evoked responses suggests that this nucleus is not the sole source of surround vibrissae input to VPM neurons.
authors.affiliation: Department of Anatomy and Neurobiology, Medical College of Ohio, Toledo 43699, USA. nchiaiagemini.mco.edu
authors.forename: N L
authors.initials: NL
authors.lastname: Chiaia
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: R W
authors.initials: RW
authors.lastname: Rhoades
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017476:Receptors, Neuropeptide Y / Q000819:agonists*; D013787:Thalamic Nuclei / Q000166:cytology / Q000187:drug effects*; D014278:Trigeminal Nuclei / Q000502:physiology*; D014738:Vibrissae
chemical_list: D017476:Receptors, Neuropeptide Y