Upregulation of stathmin (p19) gene expression in adult rat brain during injury-induced synapse formation.
Stathmin (p19) is developmentally regulated as a neural-enriched phosphoprotein associated with neurite outgrowth and synaptic formation during cell proliferation and differentiation, and remains highly abundant in adult rat brain. Whether stathmin is involved in injury-induced reactive synaptogenesis in adult rat was examined in this study. Following unilateral cortical lesion, a significant increase in stathmin mRNA expression was found in the cells of contralateral homotypic cortex and in the subventricular zone of the lateral ventricle. This increase coincided in time with the corticostriatal axon sprouting and synaptic remodeling previously found in denervated striatum. Our data suggest that stathmin plays an important role in regulation of reactive synaptogenesis in adult brain.
Cheng
H W
HW
Division of Neurogerontology, Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191, USA.
Jiang
T
T
Mori
N
N
McNeill
T H
TH
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D002552:Cerebral Ventricles / Q000378:metabolism / Q000473:pathology; D003342:Corpus Striatum / Q000378:metabolism / Q000473:pathology; D007839:Functional Laterality; D005786:Gene Expression Regulation; D008297:Male; D008868:Microtubule Proteins; D010750:Phosphoproteins / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011916:Rats, Inbred F344; D050777:Stathmin; D013569:Synapses / Q000502:physiology*; D013997:Time Factors; D014158:Transcription, Genetic
D008868:Microtubule Proteins; D010750:Phosphoproteins; D012333:RNA, Messenger; D050777:Stathmin