title: KY-62, a polyene analog of amphotericin B, for treatment of murine candidiasis.
abstract: KY-62 is a water-soluble analog of amphotericin B. In vitro testing of five clinical isolates of Candida albicans showed KY-62 to have potency similar to that of amphotericin B. KY-62 was administered to mice infected intravenously with C. albicans. In vivo, KY-62 was effective in immunocompetent mice, with potency similar to that of amphotericin B. KY-62 was well tolerated up to 30 mg/kg of body weight per dose, an amount that would be lethal with amphotericin B. KY-62 was less effective in mice rendered neutropenic with 5-fluorouracil. The addition of flucytosine had little effect. KY-62 may have potential for clinical development.
authors.affiliation: University of Texas Health Science Center, San Antonio 78284, USA. graybill@uthscsa.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Graybill
authors.forename: L K
authors.initials: LK
authors.lastname: Najvar
authors.forename: A
authors.initials: A
authors.lastname: Fothergill
authors.forename: T
authors.initials: T
authors.lastname: Hardin
authors.forename: M
authors.initials: M
authors.lastname: Rinaldi
authors.forename: C
authors.initials: C
authors.lastname: Lambros
authors.forename: S L
authors.initials: SL
authors.lastname: Regen
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D051379:Mice
chemical_list: D000935:Antifungal Agents; C110373:KY-62; D000666:Amphotericin B