title: Spread of excitation in 3-D models of the anisotropic cardiac tissue. II. Effects of fiber architecture and ventricular geometry.
abstract: We investigate a three-dimensional macroscopic model of wave-front propagation related to the excitation process in the left ventricular wall represented by an anisotropic bidomain. The whole left ventricle is modeled, whereas, in a previous paper, only a flat slab of myocardial tissue was considered. The direction of cardiac fibers, which affects the anisotropic conductivity of the myocardium, rotates from the epi- to the endocardium. If the ventricular wall is conceived as a set of packed surfaces, the fibers may be tangent to them or more generally may cross them obliquely; the latter case is described by an "imbrication angle." The effect of a simplified Purkinje network also is investigated. The cardiac excitation process, more particularly the depolarization phase, is modeled by a nonlinear elliptic equation, called an eikonal equation, in the activation time. The numerical solution of this equation is obtained by means of the finite element method, which includes an upwind treatment of the Hamiltonian part of the equation. By means of numerical simulations in an idealized model of the left ventricle, we try to establish whether the eikonal approach contains the essential basic elements for predicting the features of the activation patterns experimentally observed. We discuss and compare these results with those obtained in our previous papers for a flat part of myocardium. The general rules governing the spread of excitation after local stimulations, previously delineated for the flat geometry, are extended to the present, more realistic monoventricular model.
authors.affiliation: Dipartimento di Matematica, Università di Pavia, Italy.
authors.forename: P C
authors.initials: PC
authors.lastname: Franzone
authors.forename: L
authors.initials: L
authors.lastname: Guerri
authors.forename: M
authors.initials: M
authors.lastname: Pennacchio
authors.forename: B
authors.initials: B
authors.lastname: Taccardi
mesh_terms: D000818:Animals; D006321:Heart / Q000033:anatomy & histology* / Q000502:physiology*; D006352:Heart Ventricles; D006801:Humans; D008433:Mathematics; D008955:Models, Cardiovascular; D018485:Muscle Fibers, Skeletal / Q000502:physiology