Fatty acids involved in signal cross-talk between cell membrane and nucleus.
The results presented underline the fact that the nature and the concentration of the non-esterified fatty acids (NEFAs) liberated from membrane lipids, particularly the essential ones issued from lipid nutrition, clearly belong to a large group of factors (hormones, retinoids, growth factors, cytokines...) which control the shift between cell multiplication and differentiation. NEFAs act on this shift, per se or after being metabolized, by influencing, as second messengers or modulators, the intertwined mechanisms of action of growth factors and steroid hormones. These results may explain the molecular links which exist between endocrinology, oncology and nutrition.
Nunez
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EA
Laboratoire de Biochimie Endocrinienne, Faculté de Médecine X. Bichat, Université Denis Diderot, Paris, France.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002462:Cell Membrane / Q000502:physiology*; D002467:Cell Nucleus / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism* / Q000502:physiology; D018774:Oncogene Proteins v-erbA / Q000378:metabolism / Q000502:physiology; D011987:Receptors, Steroid / Q000378:metabolism / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D005227:Fatty Acids; D018774:Oncogene Proteins v-erbA; D011987:Receptors, Steroid