[Chemotactic monocyte and activation factor (MCAF/MCP1)in material from bronchoalveolar lavage fluid of patients with chronic bronchitis].
The aim of this study was to evaluate concentrations of monocyte chemotactic and activating factor (MCAF/MCP1) in bronchoalveolar lavage fluid (BAL) from patients with chronic bronchitis. 32 patients (aged 46 +/- 2 years) with chronic bronchitis and 14 patients (aged 30.5 +/- 3.4 years) of control group took part in this study. ELISA test (kits from R&D, USA) was used to measure concentrations of this chemokine in BALF. The results indicate for significant increase of MCAF/MCP1 in BALF from patients with chronic bronchitis (mean +/- SEM = 393 +/- 105.9 pg/ml) as compared from those of control group (middle +/- SEM = 36.4 +/- 10.9 pg/ml).


CONCLUSIONS
MCAF/MCP1 may participate in creation of inflammatory changes of airways in patients with chronic bronchitis.
Jahnz-Rózyk
K
K
Kliniki Chorób Wewnetrznych i Pneumonologii Instytutu Medycyny Wewnetrznej.
Borensztejn
E
E
Faber
M
M
Płusa
T
T
Pirozyńska
E
E
Pojda
Z
Z
D000328:Adult; D001991:Bronchitis / Q000175:diagnosis* / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018945:Monocyte Chemoattractant Proteins / Q000032:analysis*
D018945:Monocyte Chemoattractant Proteins