[Role of structural polymorphism of the angiotensin-converting enzyme gene in the development of myocardial infarction].
Genotyping of angiotensin-converting enzyme (ACE) using polymerase chain reaction was conducted in 184 males with acute macrofocal infarction versus 72 males free of arterial hypertension and ischemic heart disease (controls). The age of the patients ranged from 30 to 70 years. Normotensive patients who survived myocardial infarction at the age under 60 had significantly more frequent genotype DD (in the system I/D-polymorphism of ACE gene) than controls or hypertensive patients. The involvement of genotype DD in the onset of myocardial infarction in normotensives was observed at the middle, presenile and senile age. A significant association was found between hereditary IHD loading and carriage of DD genotype in normotensive patients with myocardial infarction.
Gukova
S P
SP
Kafedra fakul'tetskoĭ terapii Sankt-Peterburgskoĭ pediatricheskoĭ meditsinskoĭ akademii, laboratoriia molekuliarnoĭ genetiki cheloveka Instituta iadernoĭ fiziki RAN
Fomicheva
E V
EV
Kovalev
Iu P
IuP
D000328:Adult; D005796:Genes; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A