Cyclin-dependent kinases: engines, clocks, and microprocessors.
Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of the eukaryotic cell division cycle and have also been implicated in the control of gene transcription and other processes. Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies. In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division.
Morgan
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Department of Physiology, University of California, San Francisco 94143-0444, USA. dmorgan@socrates.ucsf.edu
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000737:chemistry / Q000502:physiology*; D016213:Cyclins / Q000737:chemistry / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D015394:Molecular Structure
D016213:Cyclins; D018844:Cyclin-Dependent Kinases