title: Confidence intervals for relative risk estimates from affected-sib-pair data.
abstract: Confidence intervals for relative risk parameters estimated using affected-sib-pair data are derived and evaluated for two markers showing previous evidence of linkage to bipolar illness. For D18S41 we found some evidence, and for D18S37 stronger evidence, of relative risks greater than 1, although in both cases the estimated confidence intervals for the parameters are wide.
authors.affiliation: Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, Ohio 44109, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: Cordell
authors.forename: J M
authors.initials: JM
authors.lastname: Olson
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D016001:Confidence Intervals; D005819:Genetic Markers; D006801:Humans; D016013:Likelihood Functions; D016555:Matched-Pair Analysis; D009679:Nuclear Family; D018570:Risk Assessment
chemical_list: D005819:Genetic Markers