GENEHUNTER: application to analysis of bipolar pedigrees and some extensions.
A newly developed nonparametric multipoint linkage analysis (NPL) by Kruglyak et al. [1996] was applied to the data set from the Johns Hopkins Bipolar Study available through the GAW10 workshop. Our results from GENEHUNTER do not support the analyses of Stine et al. [1995]. Some possible extensions to incorporate unaffecteds are also discussed.
Li
H
H
Section of Biostatistics, Mayo Clinic/Mayo Foundation, Rochester, Minnesota, USA.
Schaid
D J
DJ
D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D009679:Nuclear Family; D010375:Pedigree; D012984:Software; D018709:Statistics, Nonparametric