Obstetric complications of antiphospholipid antibodies.
Pregnancies occurring in women with antiphospholipid antibodies are at significantly increased risk of miscarriage, prematurity, intrauterine growth retardation and preeclampsia. Insights into the pathological basis of these conditions suggest that antiphospholipid antibodies impair embryonic implantation and in later gestations cause thrombosis of the uteroplacental vasculature. This offers a rational basis for thromboprophylaxis during pregnancy.
Rai
R
R
Department of Obstetrics and Gynaecology, Imperial College School of Medicine at St Mary's, London, UK.
Regan
L
L
D000022:Abortion, Spontaneous / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D017152:Antibodies, Antiphospholipid / Q000009:adverse effects / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D007752:Obstetric Labor, Premature / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D010920:Placenta / Q000098:blood supply / Q000502:physiology; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology
D017152:Antibodies, Antiphospholipid