title: A rare case of hepatic injury associated with ovarian hyperstimulation syndrome.
abstract: A 26-year-old married woman was admitted to our hospital because of massive ascites and hepatic injury. The patient had been treated with human menopausal gonadotropin and clomiphene citrate to prevent recurrence of spontaneous abortions. About 1 month later, she developed upper abdominal pain and noticed dark urine. On admission, she had elevated concentrations of serum transaminases with an asparate aminotransferase of 127 IU/L and alanine aminotransferase of 194 IU/L. An abdominal ultrasound showed massive ascites. Her serum concentration of estradiol was high at 12,100 pg/mL, which was much greater than the value of early stage of pregnancy (2,279-7,353 pg/mL). She was thus diagnosed as having ovarian hyperstimulation syndrome. Following a period of bed rest, her liver function normalized and the ascites disappeared. Based on the above findings, the patient was considered to have suffered from ovarian hyperstimulation syndrome, complicated by hepatic injury.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Shimono
authors.forename: H
authors.initials: H
authors.lastname: Tsuji
authors.forename: K
authors.initials: K
authors.lastname: Azuma
authors.forename: M
authors.initials: M
authors.lastname: Hashiguchi
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D001510:Bed Rest; D002199:Capillary Permeability; D056486:Chemical and Drug Induced Liver Injury; D002996:Clomiphene / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000187:drug effects; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology*; D008596:Menotropins / Q000009:adverse effects / Q000494:pharmacology; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D011247:Pregnancy; D011261:Pregnancy Trimester, First
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene; D008596:Menotropins