Triterpenoid compounds from Araujia sericifera B. Effects on the isolated guinea pig ileum.
Different fractions from the methanol insoluble extract of Araujia sericifera were obtained by chromatography and evaluated for their antihistaminic effects on guinea pig ileum in vitro. In order to determine the compounds responsible for the pharmacological effects observed, separation of the components from the active fraction was performed using HPLC.
López de Medrano-Villar
M J
MJ
Departamento de Biotecnología, Universidad Politécnica de Valencia, Spain.
Bello
R
R
Esplugues
J
J
Primo-Yúfera
E
E
Primo-Millo
J
J
D000818:Animals; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000302:isolation & purification / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D010936:Plant Extracts; D014315:Triterpenes; C110693:germanicol acetate