title: Insulin injection sites: morphology and immunohistochemistry.
abstract: In a case of insulin suicide in a nondiabetic woman, insulin was detected in routinely formalin fixed and paraffin embedded subcutaneous injection marks, in spite of a post-morterm interval of 24 days. Around birefringent crystalline material, probably zinc phosphate, immunohistochemistry revealed granular insulin depots as well as an insulin staining along the lipocyte membranes. A cellular reaction of granulocytic character was present, with an uptake of insulin by inflammatory cells.
authors.affiliation: Institute of Forensic Medicine, University of Heidelberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Lutz
authors.forename: I
authors.initials: I
authors.lastname: Pedal
authors.forename: C
authors.initials: C
authors.lastname: Wetzel
authors.forename: R
authors.initials: R
authors.lastname: Mattern
mesh_terms: D001344:Autopsy / Q000379:methods*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000506:poisoning*; D007150:Immunohistochemistry; D007279:Injections, Subcutaneous; D007328:Insulin / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D011180:Postmortem Changes; D012867:Skin / Q000473:pathology*; D013405:Suicide; D013997:Time Factors
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin