title: [A case of infantile anaplastic astrocytoma treated with surgery and chemotherapy].
abstract: A 5-month-old girl presented with enlargement of the head circumference. Neurological examination revealed right hemiparesis and bulging of the anterior fontanel. T1-weighted magnetic resonance imaging with gadolinium DTPA showed a well-enhanced, huge tumor extending from the left frontal lobe to the parietal lobe. Cerebral angiography showed the main feeding arteries were the central sulcus artery and the posterior parietal artery. The tumor was totally removed using a sulcotomy and temporary clipping of these feeding arteries to control bleeding. The histological diagnosis was anaplastic astrocytoma. Postoperative radiation therapy was avoided so as to prevent the side effect of radiation therapy such as mental retardation and growth impairment. Chemotherapy using VP-16 and CDDP was given every six months as adjunct therapy. No tumor recurrence has been recognized for over a period of 2 years and 5 months after surgery and growth and mental development have been satisfactory. Total removal using great care not to damage neurological function followed by postoperative chemotherapy is the treatment of preference to obtain good prognosis and quality of survival in infant with such tumors.
authors.affiliation: Department of Neurosurgery, Yamagata University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Saino
authors.forename: T
authors.initials: T
authors.lastname: Kayama
authors.forename: K
authors.initials: K
authors.lastname: Sakurada
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Sato
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005625:Frontal Lobe / Q000601:surgery; D005909:Glioblastoma / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007223:Infant; D010296:Parietal Lobe / Q000601:surgery; D012074:Remission Induction
chemical_list: D005047:Etoposide; D002945:Cisplatin