title: [Sézary syndrome with two lymphocyte subpopulations expressing either CD4+/CD8- or CD4-/CD8+].
abstract: A 61-year-old man was admitted in March 1996 complaining of erythroderma, and Sézary syndrome was diagnosed. The leukocyte count was 33,590/microliter with 70.9% abnormal lymphocytes expressing two different types of antigenicity, either CD4+/CD8- (44.5%) or CD4-/CD8+ (48.9%). Clonal T-cell receptor beta rearrangement was not found on Southern blot analysis. He suffered repeated sepsis dueto methicillin-resistant Staphylococcus aureus. Combination chemotherapy was not effective for erythroderma and organomegaly, and deoxycoformycin revealed a transient effect. He died of MRSA enterocolitis in July 1996.
authors.affiliation: Department of Internal Medicine, Hyogo Awaji Prefectural Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Kodama
authors.forename: Y
authors.initials: Y
authors.lastname: Kataoka
authors.forename: T
authors.initials: T
authors.lastname: Tamura
authors.forename: J
authors.initials: J
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Matsuo
mesh_terms: D015704:CD4 Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes; D016827:CD8 Antigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes; D006801:Humans; D008297:Male; D008875:Middle Aged; D012751:Sezary Syndrome / Q000276:immunology*; D016176:T-Lymphocyte Subsets
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens