title: Assessment of insulin resistance in acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy.
abstract: With a euglycemic hyperinsulinemic clamp method, whole-body insulin resistance was assessed in 6 cases with acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy. The glucose infusion rate (GIR) correlated well with the plasma IGF-I level but poorly with that of GH. Further improvement in insulin sensitivity occurred 3-4 months after operation without substantial changes in plasma levels of both GH and IGF-I or glycemic control. These results indicate that GH excess can induce insulin resistance in association with plasma IGF-I and also through undefined secondary effect.
authors.affiliation: Diabetes Center, Tokyo Women's Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wasada
authors.forename: K
authors.initials: K
authors.lastname: Aoki
authors.forename: A
authors.initials: A
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Katsumori
authors.forename: K
authors.initials: K
authors.lastname: Muto
authors.forename: O
authors.initials: O
authors.lastname: Tomonaga
authors.forename: H
authors.initials: H
authors.lastname: Yokoyama
authors.forename: N
authors.initials: N
authors.lastname: Iwasaki
authors.forename: T
authors.initials: T
authors.lastname: Babazono
authors.forename: C
authors.initials: C
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Omori
authors.forename: N
authors.initials: N
authors.lastname: Hizuka
mesh_terms: D000172:Acromegaly / Q000503:physiopathology*; D000236:Adenoma / Q000601:surgery*; D000328:Adult; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000601:surgery*; D013101:Sphenoid Sinus