title: Continuous veno-venous hemodiafiltration using bicarbonate dialysate.
abstract: We report our experience with 11 children treated by continuous veno-venous hemodiafiltration. The median age was 5.0 years (range 3 days to 14 years). Access was via dual-lumen subclavian or femoral vein catheters. Hemofilters were chosen on the basis of patient size and dialysis requirements. Bicarbonate-buffered dialysis solution was prepared shortly before use by supplementation of a specially prepared base solution with commercially available electrolyte solutions. The mean ultrafiltration rate was 37.4 +/- 27 ml/kg body weight per hour. Urea and creatinine clearances were 15.1 +/- 6.4 ml/kg body weight per min and 16.4 +/- 8.4 ml/kg body weight per min, respectively. Metabolic acidosis was readily controlled in all patients. Of the 11 patients, 7 ultimately recovered normal renal function.
authors.affiliation: Department of Nephrology, Women's and Children's Hospital, North Adelaide, South Australia.
authors.forename: D
authors.initials: D
authors.lastname: Roy
authors.forename: R J
authors.initials: RJ
authors.lastname: Hogg
authors.forename: P A
authors.initials: PA
authors.lastname: Wilby
authors.forename: N
authors.initials: N
authors.lastname: Matthews
authors.forename: P H
authors.initials: PH
authors.lastname: Henning
authors.forename: K F
authors.initials: KF
authors.lastname: Jureidini
mesh_terms: D000138:Acidosis / Q000150:complications / Q000628:therapy; D000140:Acidosis, Lactic / Q000150:complications / Q000628:therapy; D058186:Acute Kidney Injury / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D000293:Adolescent; D001639:Bicarbonates / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006440:Hemofiltration; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D006435:Renal Dialysis; D016896:Treatment Outcome; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
chemical_list: D001639:Bicarbonates