Analysis of bipolar disorder using affected relatives.
We have analyzed the GAW10 data from several studies of bipolar affective disorder (BPAD) using the software packages SimIBD and SIMWALK2. SimIBD implements a simulation-based affected-pedigree-member (APM) statistic, called SimAPM, as well as an APM-like statistic, also called SimIBD, that measures identical-by-descent (IBD) sharing. SIMWALK2 uses Markov chain Monte Carlo techniques to compute several IBD-based statistics on the degree of marker-allele clustering among all affected relatives. We have found no strong evidence of linkage to either chromosome 5 or 18. However, we did find that several markers showed p-values less than 0.01 and may deserve further study.
Davis
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Department of Human Genetics, University of Pittsburgh, Pennsylvania 15261, USA.
Sobel
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Marinov
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Weeks
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D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18; D002895:Chromosomes, Human, Pair 5; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D009010:Monte Carlo Method; D010375:Pedigree; D012984:Software
D005819:Genetic Markers