Pre-TCR/CD3 and TCR/CD3 complexes: decamers with differential signalling properties?
Currently, the favoured model for the structure of the T-cell receptor (TCR)/CD3 complex proposes a monovalent TCR alpha beta/CD3 gamma epsilon delta epsilon zeta zeta octameric complex. However, other biochemical, structural and functional data point to a bivalent (TCR alpha beta)2/CD3 gamma epsilon delta epsilon zeta zeta decameric organization, which has a favourable neutral transmembrane net charge within the complex. Here, Heinz Jacobs proposes a model for the organization of the pre-TCR and discusses its function in signal transduction.
Jacobs
H
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Basel Institute for Immunology, Switzerland. Jacobs@BII.CH
D017252:CD3 Complex / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D008956:Models, Chemical; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000737:chemistry* / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000737:chemistry / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology
D017252:CD3 Complex; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta