Chondrosarcoma of the larynx: the role of radiotherapy revisited--a case report and review of the literature.
BACKGROUND
Experience in the treatment of laryngeal chondrosarcoma is based on about 250 cases reported to date. The standard therapy is conservative surgery. Radiotherapy has universally been regarded as ineffective in the treatment of this disease.


METHODS
A patient with a laryngeal chondrosarcoma was observed for 11 years after radical radiotherapy. The literature on laryngeal chondrosarcoma was critically reviewed, with emphasis placed on radiotherapy.


RESULTS
The review of the literature revealed that experience with radiotherapy of laryngeal chondrosarcoma has been lacking, with fewer than 10 cases with short follow-up documented up to now. Meanwhile, increasing evidence of the efficacy of radiotherapy in the treatment of skeletal chondrosarcoma has emerged. The authors report the first case of chondrosarcoma of the larynx in which radical radiotherapy resulted in a long term remission of more than 10 years.


CONCLUSIONS
Radiotherapy should be considered when radical surgery is not feasible without severe mutilation. It should also be considered for the treatment of residual disease. Laryngectomy should be restricted to salvage treatment when radiotherapy fails. In this study, radiotherapy appeared to be an effective modality in the treatment of low grade laryngeal chondrosarcoma, and these results contrast with the current widespread disapproval of this treatment.
Gripp
S
S
Department of Radiation Oncology, Heinrich-Heine-University Duesseldorf, Germany.
Pape
H
H
Schmitt
G
G
D000368:Aged; D001859:Bone Neoplasms / Q000532:radiotherapy; D002813:Chondrosarcoma / Q000532:radiotherapy* / Q000601:surgery; D005240:Feasibility Studies; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D008137:Longitudinal Studies; D008297:Male; D018365:Neoplasm, Residual / Q000532:radiotherapy; D012074:Remission Induction; D016879:Salvage Therapy; D016896:Treatment Outcome