Remnants of Albunex nucleate acoustic cavitation.
Mice were injected with 0.1 mL Albunex and exposed to 200 pulses from a piezoelectric lithotripter at times ranging from 5 min to 24 h following injection. Each pulse was approximately 1.5 sinusoidal oscillations at a fundamental frequency of approximately 0.1 MHz with pressure amplitude of approximately 2 MPa. Although the contrast agent ceases to be an effective scatterer of diagnostic ultrasound after a few minutes in the circulation, the modest lithotripter exposures caused significant hemorrhaging in bladder, mesentery and intestine for periods of up to 4 h after injection. The results demonstrate either that highly stable bubbles much smaller than resonance size or air-containing fragments of the shells of Albunex serve as effective nuclei for acoustic cavitation.
Dalecki
D
D
Rochester Center for Biomedical Ultrasound, University of Rochester, NY 14627, USA.
Raeman
C H
CH
Child
S Z
SZ
Penney
D P
DP
Carstensen
E L
EL
D000418:Albumins / Q000008:administration & dosage; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000473:pathology; D006417:Hematuria / Q000209:etiology / Q000473:pathology; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology; D007275:Injections, Intravenous; D008096:Lithotripsy / Q000009:adverse effects; D008171:Lung Diseases / Q000209:etiology / Q000473:pathology; D008297:Male; D051379:Mice; D008863:Microspheres; D014463:Ultrasonography / Q000009:adverse effects*
D000418:Albumins; C060687:Albunex; D003287:Contrast Media