[The metabolic therapy of ischemic stroke: the use of nootropil].
54 patients were treated by notropil (pyracetam). The results of therapy were evaluated statistically according to a number of clinical scales and neurophysiologic indices (EEG and evoked potentials with mapping of bioelectric activity). The results were compared with the data about 56 patients of the control group which were treated by traditional method without application of notropil. Notropil was applied by two ways: small doses (4-12 g daily) during 5 days or high doses (10-12 g daily) during 30 days from the moment when the patient admitted to the hospital. Intravenous injections of the drug were used in all cases as well as its internal administration. It was showed either efficiency of the drug, especially in high doses, in early beginning of the treatment and its duration for at least 30 days or good tolerance of the drug. Authors supposed that application of pyracetam is not adequate in strokes with severe disorders of consciousness and cerebral edema.
Gusev
E I
EI
Burd
G S
GS
Gekht
A B
AB
Skvortsova
V I
VI
Selikhova
M V
MV
Pavlov
N A
NA
Bolotov
D A
DA
Beliakov
V V
VV
Vanichkin
A V
AV
Konstantinova
M V
MV
D000208:Acute Disease; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D010889:Piracetam / Q000008:administration & dosage*; D013997:Time Factors
D018696:Neuroprotective Agents; D010889:Piracetam