5-HT1Dbeta receptor mediates the supersensitivity of isolated coronary artery to serotonin in variant angina.
Although serotonin (5-hydroxytryptamine; 5-HT) is used for provocation of coronary spasm, 5-HT receptor subtypes in spastic coronary arteries remain undetermined. We demonstrated the supersensitivity of isolated coronary artery to ergonovine, 5-HT, and sumatriptan, a 5-HT1D receptor agonist, in a patient with variant angina. Furthermore, we detected gene expression of 5-HT1Dbeta and 5-HT2A receptors in spastic coronary artery using RNase protection assay. These findings suggest that the leftward shift of the dose-response curve for 5-HT, which plays an important role in the pathogenesis of coronary spasm, is mediated by activation of 5-HT1Dbeta receptor.
Ishida
T
T
First Department of Internal Medicine, Kobe University School of Medicine, Japan.
Hirata
K
K
Sakoda
T
T
Kanazawa
K
K
Kawashima
S
S
Akita
H
H
Yokoyama
M
M
D000788:Angina Pectoris, Variant / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D003331:Coronary Vessels / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000378:metabolism; D004874:Ergonovine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D015870:Gene Expression; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects; D012333:RNA, Messenger / Q000096:biosynthesis; D044346:Receptor, Serotonin, 5-HT1D; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D012701:Serotonin / Q000008:administration & dosage / Q000009:adverse effects; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects; D018170:Sumatriptan / Q000008:administration & dosage / Q000009:adverse effects; D014661:Vasoconstriction / Q000187:drug effects
D010120:Oxytocics; D012333:RNA, Messenger; D044346:Receptor, Serotonin, 5-HT1D; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D018170:Sumatriptan; D004874:Ergonovine