title: Empirical affected-sib-pair statistics: two simulation strategies.
abstract: We compare two simulation procedures used to determine empirical distributions of three affected sib-pair test-statistics in family samples with missing parental marker information. P1 and P2 procedures differ according to whether affected sibs' genotypes are ignored (P1) or accounted for (P2) to generate the unknown parental genotypes. Overall, our results show that P2 procedure performs better than P1, particularly when marker heterozygosity is high (H = 75%) or when marker data from unaffected siblings are available with low marker heterozygosity (H = 50%). These results are similar for all affected sib-pair tests.
authors.affiliation: CNRS EP10, Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Dina
authors.forename: J C
authors.initials: JC
authors.lastname: Buzzi
authors.forename: F
authors.initials: F
authors.lastname: Demenais
authors.forename: M
authors.initials: M
authors.lastname: Martinez
mesh_terms: D003198:Computer Simulation; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D009679:Nuclear Family; D010290:Parents
chemical_list: D005819:Genetic Markers