Plasma apolipoprotein A-I, apolipoprotein B, and lipoprotein(a) concentrations in normoglycemic Hispanics and non-Hispanic whites from the San Luis Valley, Colorado.
Lower levels of plasma apolipoprotein (apo) A-I and higher levels of apoB, lipoprotein(a) (Lp(a)), and the ratio of apoB to apoA-I are considered to be independent risk factors for coronary heart disease. To examine race differences in the distributions of plasma levels of apoA-I, apoB, and Lp(a), the authors have determined quantitative levels of these traits in 252 nondiabetic Hispanics and 459 nondiabetic non-Hispanic whites (NHWs) from the San Luis Valley, Colorado. Hispanic men and women, respectively, had significantly higher plasma apoB levels (p < 0.003; p < 0.01) and the ratio of apoB to apoA-I (p < 0.003; p < 0.0003) than their NHW counterparts. Plasma Lp(a) concentrations were also significantly higher in Hispanic men (p < 0.003) and apoA-I levels were significantly lower in Hispanic women (p < 0.0003) than NHW men and women, respectively. Overall, the threshold points of apoA-I (< 120 mg/dl), apoB (> 120 mg/dl), and Lp(a) (> 25 mg/dl) were higher in Hispanics than in NHWs for apoA-I (22.8 vs. 15.7%), apoB (16.9 vs. 9.9%), and Lp(a) (18.6 vs. 12.4%). These data suggest that the quantitative risk profile for coronary heart disease with respect to these three quantitative traits is not favorable for Hispanics compared with that for NHWs in the San Luis Valley, Colorado.
Kamboh
M I
MI
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA. Ikamboh@helix.hgen.pitt.edu
Rewers
M
M
Aston
C E
CE
Hamman
R F
RF
D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D003120:Colorado; D003327:Coronary Disease / Q000209:etiology; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019655:Quantitative Trait, Heritable; D012307:Risk Factors; D044465:White People
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D017270:Lipoprotein(a)