title: Use of transgenic mice in lipoprotein metabolism and atherosclerosis research.
abstract: In APOE*3-Leiden transgenic mice the atherosclerotic lesion size is correlated with plasma cholesterol. In these mice the plasma lipid levels are positively correlated with the relative amount of APOE 3-Leiden protein on the VLDL particle. The plasma cholesterol levels are influenced by diet, age and gender, mainly due to an effect of these factors on VLDL production rate. Excess of APOC1 protein does inhibit the hepatic clearance of VLDL remnant particles, whereas excess of apoE leads to a hampered extra-hepatic lipolysis of VLDL triglyceride.
authors.affiliation: TNO-PG, Gaubius Laboratory, Leiden, The Netherlands.
authors.forename: L M
authors.initials: LM
authors.lastname: Havekes
authors.forename: B J
authors.initials: BJ
authors.lastname: van Vlijmen
authors.forename: M C
authors.initials: MC
authors.lastname: Jong
authors.forename: K W
authors.initials: KW
authors.lastname: van Dijk
authors.forename: M H
authors.initials: MH
authors.lastname: Hofker
mesh_terms: D000367:Age Factors; D000818:Animals; D053318:Apolipoprotein E3; D001056:Apolipoproteins C / Q000378:metabolism; D001057:Apolipoproteins E / Q000172:deficiency*; D001161:Arteriosclerosis / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D053318:Apolipoprotein E3; D001056:Apolipoproteins C; D001057:Apolipoproteins E; D008055:Lipids; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D002784:Cholesterol