Photoreceptor development: breaking down the barriers.
One form of the Tramtrack protein (Ttk88) acts as a general inhibitor of photoreceptor differentiation in developing Drosophila eyes. This inhibition is removed by targeting Ttk88 for degradation, which requires two proteins, Phyl and Sina, previously thought to act in the determination of specific photoreceptor subtypes.
Dickson
B J
BJ
Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology; D002454:Cell Differentiation; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D009024:Morphogenesis; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D017956:Photoreceptor Cells, Invertebrate / Q000196:embryology*; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism; D016335:Zinc Fingers; D018631:ras Proteins / Q000502:physiology; D000098563:Seven in Absentia Proteins
D029721:Drosophila Proteins; D019476:Insect Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D014452:Ubiquitins; C092070:phyl protein, Drosophila; C075878:ttk protein, Drosophila; D044767:Ubiquitin-Protein Ligases; D000098563:Seven in Absentia Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D018631:ras Proteins