Cortico-cortical connections from somatosensory areas to the motor area of the cortex following peripheral nerve lesion in the cat.
Cortico-cortical connections of the forelimb digital area of the motor cortex (MCx) following peripheral nerve lesion were examined using horseradish peroxidase (HRP) in adult cats. A small amount of HRP injection was made into the digital area of the MCx in the control animals with intact nerves. HRP labelled cells were found in the first somatosensory area (SI; areas 1-2, 3a and 3b), secondary somatosensory area (SII) and area 5 of the ipsilateral cortex. In addition, a small number of HRP labelled cells were found in the contralateral cortex located in area 4 (MCx) and area 3a of SI. In the experimental animals, peripheral nerves were cut and after 2 or 3 months of survival, HRP was injected to the corresponding area of the MCx. The HRP labelled cells were found in SI (areas 2, 3a, 3b), SII, SIII, SIV and SV and in areas Id and 5 of the ipsilateral cortex. Furthermore, HRP-labelled cells were found in area 4 of the MCx, in SI (3a), SII, SIV and Id on the contralateral side of the cortex. HRP-labelled cells were located in layers II, III and V. Most of these cells were found in layer III.
Mori
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College of Humanities and Sciences, Nihon University, Tokyo, Japan.
D000818:Animals; D001370:Axonal Transport; D001931:Brain Mapping; D002415:Cats; D005260:Female; D007839:Functional Laterality; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008959:Models, Neurological; D009044:Motor Cortex / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology*; D011826:Radial Nerve / Q000502:physiology; D012867:Skin / Q000294:innervation; D014459:Ulnar Nerve / Q000502:physiology; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate