title: Targets in cytokine activation.
abstract: The first morning session of the Eighth International Conference of the Inflammation Research Association was titled 'Targets in Cytokine Activation'. It encompassed four areas of research that may be considered as either current or future targets. Probably the best established target of the four is interleukin-1 beta converting enzyme (ICE) and Winnie Wong from BASF Bioresearch Corporation presented an overview of work in this field. This was followed by a newly emerging target called TACE (TNF-alpha converting enzyme) in a presentation from Douglas Cerretti of Immunex. The final two presentations covered work with chemoattractant receptors (Craig Gerard, Harvard) and mice where the inducible NO synthase gene had been deleted (John Mudgett, Merck).
authors.affiliation: Department of Biochemistry, Parke-Davis Research Division, Warner-Lambert Company, Ann Arbor, Michigan, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Giegel
authors.forename: D D
authors.initials: DD
authors.lastname: Chaplin
mesh_terms: D051722:ADAM Proteins; D000072198:ADAM17 Protein; D000818:Animals; D020170:Caspase 1; D003546:Cysteine Endopeptidases; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D008666:Metalloendopeptidases; D051379:Mice; D019707:Receptors, Chemokine
chemical_list: D016207:Cytokines; D019707:Receptors, Chemokine; D003546:Cysteine Endopeptidases; D020170:Caspase 1; D051722:ADAM Proteins; D008666:Metalloendopeptidases; D000072198:ADAM17 Protein; C000606462:ADAM17 protein, human; C000606463:Adam17 protein, mouse