title: Proposed changes in the classification of carcinogenic chemicals in the work area.
abstract: Carcinogenic chemicals in the work area are currently classified into three categories in Section III of the German List of MAK and BAT Values. This classification is based on qualitative criteria and reflects essentially the weight of evidence available for judging the carcinogenic potential of the chemicals. It is proposed that these Categories--IIIA1, IIIA2, and IIIB--be retained as Categories 1, 2, and 3, to conform with EU regulations. On the basis of our advancing knowledge of reaction mechanisms and the potency of carcinogens, it is now proposed that these three categories be supplemented with two additional categories. The essential feature of substances classified in the new categories is that exposure to these chemicals does not convey a significant risk of cancer to man, provided that an appropriate exposure limit (MAK value) is observed. It is proposed that chemicals known to act typically by nongenotoxic mechanisms and for which information is available that allows evaluation of the effects of low-dose exposures be classified in Category 4. Genotoxic chemicals for which low carcinogenic potency can be expected on the basis of dose-response relationships and toxicokinetics and for which risk at low doses can be assessed will be classified in Category 5. The basis for a better differentiation of carcinogens is discussed, the new categories are defined, and possible criteria for classification are described. Examples for Category 4 (1,4-dioxane) and Category 5 (styrene) are presented. The proposed changes in classifying carcinogenic chemicals in the work area are presented for further discussion.
authors.affiliation: Institute for Toxicology and Pharmacology, University of Würzburg, Germany.
authors.forename: H G
authors.initials: HG
authors.lastname: Neumann
authors.forename: H W
authors.initials: HW
authors.lastname: Thielmann
authors.forename: J G
authors.initials: JG
authors.lastname: Filser
authors.forename: H P
authors.initials: HP
authors.lastname: Gelbke
authors.forename: H
authors.initials: H
authors.lastname: Greim
authors.forename: H
authors.initials: H
authors.lastname: Kappus
authors.forename: K H
authors.initials: KH
authors.lastname: Norpoth
authors.forename: U
authors.initials: U
authors.lastname: Reuter
authors.forename: S
authors.initials: S
authors.lastname: Vamvakas
authors.forename: P
authors.initials: P
authors.lastname: Wardenbach
authors.forename: H E
authors.initials: HE
authors.lastname: Wichmann
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000145:classification* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced; D016273:Occupational Exposure
chemical_list: D002273:Carcinogens