Ecabapide, a novel gastroprokinetic agent, ameliorates gastric emptying of stroke-prone spontaneously hypertensive rats (SHRSP).
The effect of ecabapide, a novel gastroprokinetic agent, on gastric emptying was examined in stroke-prone spontaneously hypertensive rats (SHRSP), which are known to exhibit gastric malfunctions as a result of autonomic nervous system disorder. Ecabapide was administered orally to SHRSP in various dose-regimens. Gastric emptying was evaluated by the acetaminophen (APAP) method using semi-solid meal under the conscious conditions. Ecabapide significantly enhanced gastric emptying of SHRSP at 1 mg/kg in single administration, 0.3 and 1 mg/kg in 2-week treatment and 7.7 mg/kg in 4-week (diet) exposure. These results suggest that the effect of ecabapide is exerted without showing tachyphylaxis.
Furuhama
K
K
Tokyo Research and Development Center, Daiichi Pharmaceutical Co., Ltd., Japan.
D000082:Acetaminophen / Q000494:pharmacology; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000503:physiopathology; D001549:Benzamides / Q000008:administration & dosage / Q000494:pharmacology*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000503:physiopathology*; D004198:Disease Susceptibility; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D013618:Tachyphylaxis / Q000502:physiology; D013997:Time Factors
D018712:Analgesics, Non-Narcotic; D000897:Anti-Ulcer Agents; D001549:Benzamides; D000082:Acetaminophen; C058308:ecabapide