[Favorable effect of treatment with statins on the intima of the common carotid artery in patients with familial hyperlipoproteinemia].
BACKGROUND
In recent years evidence was provided that by measuring the width of the intima of the carotid artery, evaluated by sonography, it is possible to assess the development of arteriosclerosis. The authors used this method to evaluate hypolipidaemic treatment.


RESULTS
The authors followed-up by clinical and laboratory methods and treated for a period of 47 months 63 patients with familial hyperlipoproteinaemia. At the beginning and at the end of the follow-up period they made sonographic examinations of the common carotid artery. In 31 patients treated by statins they observed statistically significant changes: cholesterol declined by 23%, LDL cholesterol by 25.3%. The maximal rate in the common carotid artery (ACC) declined from 93 +/- 22 to 73 +/- 13 cm/s. The diameters of the ACC increased from 6.0 +/- 0.8 to 6.5 +/- 0.8 mm. The intima of the ACC diminished from 0.84 +/- 0.26 to 0.75 +/- 0.20 mm. In 22 patients treated with fibrates the anticipated lipid changes occurred. The diameter of ACC did not change, the decline in the width of the intima of the ACC was not statistically significant. In 10 patients who decided that they wanted only dietary treatment the changes in the investigated parameters were small.


CONCLUSIONS
In patients with familial hyperlipidaemia who were treated with statins for almost four years the authors observed a diminution of the width of the intima of the common carotid artery which is considered a sign of regressing atherosclerosis.
Spácil
J
J
III. interní klinika VFN a I. LF UK, Praha.
Ceska
R
R
Petrásek
J
J
Sobra
J
J
D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging*; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006938:Hyperlipoproteinemia Type II / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008148:Lovastatin / Q000627:therapeutic use*; D008875:Middle Aged; D019821:Simvastatin / Q000627:therapeutic use*; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D014463:Ultrasonography
D000924:Anticholesteremic Agents; D008148:Lovastatin; D019821:Simvastatin