The role of endogenous acid in the development of acute gastric ulcer induced by ischemia-reperfusion in the rat.
We investigated the role of endogenous gastric acid in the development of gastric ulcer from erosion induced by ischemia-reperfusion of the celiac artery in the rat. A half-hour clamping of the celiac artery (ischemia) caused acute gastric erosions 1 hour after reperfusion and such acute injuries progressed to ulcers 48-72 hours after reperfusion without any necrotizing agents. Gastric acid secretion decreased immediately after ischemia and didn't recover until 12 hours after reperfusion. Intraperitoneal administrations of cimetidine (100 mg/kg, every 12 hours) or omeprazole (30 mg/kg, every 24 hours) were started at 1, 6, or 12 hours after reperfusion. When administrations were started 1 hour after reperfusion, both drugs significantly decreased the total damaged area and prevented the progression of gastric erosions to ulcers. However, administrations started 6 or 12 hours after reperfusion failed to inhibit the total damaged area and to prevent ulcer formation. These results suggest that endogenous gastric acid may play an important role in the progression of gastric erosions to ulcers although ischemia itself reduces acid secretion. Furthermore, treatment with anti-acid-secretory drugs in the early stage of mucosal damage may be important for the prevention of ulcer.
Nakamoto
K
K
Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan. taropy@grape.med.tottori-u.ac.jp
Wada
K
K
Kitano
M
M
Kishimoto
Y
Y
Ashida
K
K
Kamisaki
Y
Y
Kawasaki
H
H
Itoh
T
T
D000208:Acute Disease; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D007511:Ischemia / Q000150:complications*; D008297:Male; D009853:Omeprazole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000209:etiology*; D013270:Stomach / Q000098:blood supply / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism / Q000473:pathology
D000897:Anti-Ulcer Agents; D002927:Cimetidine; D009853:Omeprazole