title: Use of transgenic mutational test systems in risk assessment of carcinogens.
abstract: Two transgenic in vivo mutation assays are described which are based on LacZ (Muta Mouse) and LacI (Big Blue) shuttle vector systems. Their utility has already been explored by a number of investigators including our laboratory. The evaluation of data derived from these assays confirm that they offer a practical method for studying mutagenic activity and mechanism in a wide range of tissues including those of the respiratory and gastrointestinal tract. Therefore, these transgenic mutation assays are valuable tools to assess the organotropic effects of genotoxic carcinogens.
authors.affiliation: Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre, Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Schmezer
authors.forename: C
authors.initials: C
authors.lastname: Eckert
authors.forename: U M
authors.initials: UM
authors.lastname: Liegibel
authors.forename: R G
authors.initials: RG
authors.lastname: Klein
authors.forename: H
authors.initials: H
authors.lastname: Bartsch
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002273:Carcinogens / Q000633:toxicity; D051379:Mice; D008822:Mice, Transgenic; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity; D009603:Nitroso Compounds / Q000633:toxicity; D051381:Rats; D018570:Risk Assessment
chemical_list: D002273:Carcinogens; D009153:Mutagens; D009603:Nitroso Compounds; C008651:4-nitrosodimethylaniline