Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells: resurrection of old theories by new findings.
Since the initial observations by Kaiser and Edelman, interest in the role of calcium in ACS-induced apoptosis has wavered, in part because of the fact that extracellular calcium is only necessary for induction of apoptosis in thymocytes, but not in peripheral lymphocytes or lymphoma cells. Now, as result of molecular evidence implicating two separate ligand-gated calcium channels in ACS-induced apoptosis, interest in the role of calcium is sure to be renewed. The major challenge lies in determining the signal transduction pathway through which ACS-induced calcium fluxes mediate apoptosis.
Distelhorst
C W
CW
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106-4937, USA.
Dubyak
G
G
D017209:Apoptosis; D002118:Calcium / Q000502:physiology*; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008954:Models, Biological; D011983:Receptors, Purinergic / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology*
D005938:Glucocorticoids; D011983:Receptors, Purinergic; D002118:Calcium