[Intraocular neovascularization].
To investigate the mechanism of intraocular neovascularization, we studied how vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) are expressed in the ocular tissues under hypoxic conditions. Prior to proliferation of vascular endothelial cells resulting in neovascularization, the retinal tissues such as pericytes, retinal glial cells, ganglion cells, and ciliary epithelium react directly to hypoxia expressing VEGF and/or IL-8 and stimulate endothelial cell proliferation in a paracrine manner. We demonstrated that transcription factor activator protein-1 (AP-1) is activated for expression of VEGF messenger ribonuculeic acid (mRNA) and in a similar way nuclear factor kappa B (NF-kappa B) is activated for expression of IL-8 mRNA. However, hypoxia-induced expression of VEGF and/ or IL-8 is only one aspect of the complicated processes in intraocular neovascularization. We hope that further detailed analysis of the mechanism will make it possible to inhibit and treat clinically intraocular neovascularization in the near future.
Inomata
H
H
Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka-ken, Japan.
Ishibashi
T
T
Murata
T
T
Iwasaki
M
M
Tahara
A
A
Hata
K
K
Yoshida
A
A
Yoshida
S
S
Onishi
Y
Y
Murakami
M
M
Yamamoto
M
M
Kubota
T
T
Kawano
Y
Y
Sugai
S
S
Sakamoto
T
T
Okada
T
T
Ishimoto
S
S
Fujisawa
K
K
Honda
T
T
Sakamoto
M
M
Shigefuji
M
M
Tsuji
I
I
Nishioka
K
K
Ueno
A
A
Nagatomi
Y
Y
D000328:Adult; D000818:Animals; D016228:Endothelial Growth Factors / Q000502:physiology; D006801:Humans; D016209:Interleukin-8 / Q000502:physiology; D008222:Lymphokines / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D015861:Retinal Neovascularization / Q000503:physiopathology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D016209:Interleukin-8; D008222:Lymphokines; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors