title: Clinical features of autosomal dominant congenital nystagmus linked to chromosome 6p12.
abstract: OBJECTIVE
  To describe the clinical features of a large pedigree with autosomal dominant congenital nystagmus linked to chromosome 6p12.
  
  
  METHODS
  In a prospective evaluation of 54 living family members in a single pedigree, 21 persons were affected with autosomal dominant congenital nystagmus, and clinical examinations were performed on 14. Selected persons underwent further studies, including electroretinography, scanning laser ophthalmoscopy, nerve fiber layer studies, visual evoked potential studies, and eye movement recordings.
  
  
  RESULTS
  Among seven affected persons whose parents were able to report whether the nystagmus was present congenitally, onset at birth was noted in two persons and between 3 and 6 months in five persons. Best-corrected binocular Snellen visual acuity ranged from 20/30 to 20/100, with a mode of 20/50. Strabismus was present in 14 examined patients (36%). Eye movement recordings, performed on five persons, included asymmetric pendular (three), asymmetric pendular combined with dual waveform jerk (one), and unidirectional jerk nystagmus (one).
  
  
  CONCLUSIONS
  Autosomal dominant congenital nystagmus represents a disorder with variable expressivity. While onset is typically during infancy, it can be noted at birth. Intrafamilial variation in visual acuity, ocular alignment, and nystagmus waveform suggests a role for modifying influences on expression of disease.
authors.affiliation: Johns Hopkins Center for Hereditary Eye Diseases, Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD 21287-9237, USA. kerrison@welchlink.welch.jhu.edu
authors.forename: J B
authors.initials: JB
authors.lastname: Kerrison
authors.forename: R K
authors.initials: RK
authors.lastname: Koenekoop
authors.forename: V J
authors.initials: VJ
authors.lastname: Arnould
authors.forename: D
authors.initials: D
authors.lastname: Zee
authors.forename: I H
authors.initials: IH
authors.lastname: Maumenee
mesh_terms: D000328:Adult; D000368:Aged; D002675:Child, Preschool; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004584:Electronystagmography; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005133:Eye Movements / Q000502:physiology; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009759:Nystagmus, Pathologic / Q000151:congenital* / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D009887:Ophthalmoscopy; D009900:Optic Nerve / Q000502:physiology; D010375:Pedigree; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology