Wallerian degeneration in ICAM-1-deficient mice.
Wallerian degeneration of the peripheral nervous system was studied in ICAM-1-deficient mice and compared with the phenomena observed in C57BL wild-type animals. There was a decrease in myelin density in both mice strains 4 and 6 days after transection of the sciatic nerve. The degenerating nerves were invaded by Mac-1-, LFA-1-, and F4/80-positive macrophages; significantly lower numbers of macrophages were present in ICAM-1-deficient nerves. Myelin loss decreased after nerve transection with a more prominent loss in ICAM-1-deficient animals. Schwann cells revealed a much higher myelin load in these animals when compared with wild-type nerves, and there was an increased proliferation of endoneurial cells in ICAM-1-deficient mice. These data indicate that ICAM-1 is involved in macrophage recruitment to injured peripheral nerves as well as in the proliferative and phagocytic response of Schwann cells after peripheral nerve transection.
Vougioukas
V I
VI
Department of Neuropathology, University of Göttingen, Germany.
Roeske
S
S
Michel
U
U
Brück
W
W
D000818:Animals; D002455:Cell Division / Q000502:physiology; D003714:Denervation; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009186:Myelin Sheath / Q000378:metabolism; D012583:Schwann Cells / Q000378:metabolism / Q000473:pathology; D012584:Sciatic Nerve / Q000473:pathology / Q000503:physiopathology; D014855:Wallerian Degeneration / Q000473:pathology / Q000503:physiopathology*
D018799:Intercellular Adhesion Molecule-1