title: Nonsteroidal anti-inflammatory agents: potential modifiers of periodontal disease progression.
abstract: The most recent studies of NSAIDs as potential modifiers of periodontal disease progression are reviewed. These studies indicate that NSAIDs have the ability to alter or control the progression of periodontal disease. Reductions in gingival inflammation and in bone loss have been observed following the administration of various NSAIDs. In some cases, bone gain has been achieved. More research is required to determine the possible long-term side effects associated with the chronic usage of NSAIDs, as well as to achieve consensus on the most effective drug for the control of periodontal disease. Until this occurs, and this application of NSAIDs receives government approval, the use of these drugs to control periodontal disease is not recommended.
authors.affiliation: University of British Columbia.
authors.forename: N
authors.initials: N
authors.lastname: Pauletto
authors.forename: J G
authors.initials: JG
authors.lastname: Silver
authors.forename: H
authors.initials: H
authors.lastname: Larjava
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D016301:Alveolar Bone Loss / Q000503:physiopathology / Q000517:prevention & control; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D018450:Disease Progression; D017277:Drug Approval; D005891:Gingivitis / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D008137:Longitudinal Studies; D010510:Periodontal Diseases / Q000503:physiopathology / Q000517:prevention & control*; D011448:Prostaglandin Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011448:Prostaglandin Antagonists