The role of smoothing techniques in the interpretation of results from genomic scans using sib-pair data.
We compare the results of genomic scans conducted with the Haseman-Elston sib-pair method using either (1) the average marker information from several adjacent loci or (2) each marker individually. Under smoothing, the squared sib-pair trait difference is regressed on the average number of alleles shared identical by descent averaged at several adjacent loci. This results in a significant decrease in the number of false-positives when compared to the individual marker approach. Linkage of Q4 to MG4 was found only with smoothing but not the individual marker approach. Overall, smoothing resulted in the loss of two true linkages.
Siegmund
K D
KD
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Todorov
A A
AA
Rao
D C
DC
Borecki
I B
IB
D000483:Alleles; D002898:Chromosomes, Human, Pair 8; D003627:Data Interpretation, Statistical; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D016555:Matched-Pair Analysis; D009679:Nuclear Family; D011237:Predictive Value of Tests; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis; D018709:Statistics, Nonparametric
D005819:Genetic Markers