title: Immunization of Aotus monkeys with recombinant Plasmodium falciparum hybrid proteins does not reproducibly result in protection from malaria infection.
abstract: Plasmodium falciparum antigens SERP, HRPII, MSAI, and 41-3 have shown promise as vaccine components. This study aimed at reproducing and extending previous results using three hybrid molecules. Antibody responses were reproduced in Aotus monkeys, but solid protection from a P. falciparum blood-stage challenge that showed an unintendedly enhanced pathogenicity was not observed.
authors.affiliation: Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands. kocken@bprc.nl
authors.forename: C H
authors.initials: CH
authors.lastname: Kocken
authors.forename: E
authors.initials: E
authors.lastname: Hundt
authors.forename: B
authors.initials: B
authors.lastname: Knapp
authors.forename: D
authors.initials: D
authors.lastname: Brazel
authors.forename: B
authors.initials: B
authors.lastname: Enders
authors.forename: D L
authors.initials: DL
authors.lastname: Narum
authors.forename: J A
authors.initials: JA
authors.lastname: Wubben
authors.forename: A W
authors.initials: AW
authors.lastname: Thomas
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis* / Q000276:immunology; D000953:Antigens, Protozoan / Q000235:genetics / Q000276:immunology; D016645:Aotidae; D016778:Malaria, Falciparum / Q000276:immunology* / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D016052:Protozoan Vaccines; D011994:Recombinant Proteins / Q000276:immunology*; D014611:Vaccination
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D011994:Recombinant Proteins; C057495:serine repeat antigen, Plasmodium