title: Simulation of pulmonary damages induced by inhaled Cl2 on the bronchial tree.
abstract: We have measured the change of lung mechanical parameters on isolated rabbit lungs exposed to chlorine gas (Cl2). Experimental results show parallel increase in elastance and resistance of impaired lungs. We tried to determine whether this may be explained by a reduction of the ventilated areas in the lung, consecutive to closure of some airways. We have been tried to simulate these experimental results by studying the effects of various airways occlusions imposed on two concurrent models (symmetrical and dissymmetrical) of the tracheo-bronchial tree. For each model, we successively evaluated the resistance of the normal lung, simulated a partial peripheral airways occlusion and estimated the induced changes in total resistance. Analytical expressions of the "occluded lung" elastance and resistance have been found for the symmetrical model but not for the dissymmetrical model (a graphical approach is proposed). With the symmetrical model, simulated results are comparable to experimental ones when the occlusion level is proximal. Whatever the dissymmetry level (delta) of the fractal tree model, we could not simulate the expected increase in resistance with the observed increase in elastance. We conclude that either the occlusion in non homogeneous or the lung impairment is not only a reduction in ventilated areas.
authors.affiliation: Laboratoire PRETA/TIMC/IMAG, Faculté de Médecine de Grenoble, Université Joseph Fourier, La Tronche, France.
authors.forename: P F
authors.initials: PF
authors.lastname: Baconnier
authors.forename: C
authors.initials: C
authors.lastname: Marey
authors.forename: A
authors.initials: A
authors.lastname: Ménaouar
mesh_terms: D000403:Airway Resistance / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D015824:Blood-Air Barrier / Q000187:drug effects / Q000502:physiology; D002713:Chlorine / Q000633:toxicity*; D004195:Disease Models, Animal; D005740:Gases; D008170:Lung Compliance / Q000187:drug effects* / Q000502:physiology; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology; D011817:Rabbits; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000503:physiopathology; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology
chemical_list: D005740:Gases; D002713:Chlorine