[Tumor necrosis factor-alpha--biological and immunologic properties].
The studies investigating antitumor efficacy of bacterial infections, started by Coley, resulted in isolation of tumor necrosis factor (TNF-alpha), released by activated macrophages. It was hoped that direct and indirect cytotoxic, cytostatic and immunomodulatory effects of TNF-alpha would prove helpful in obtaining an effective antitumor drug. In this paper, we describe biologic and immunologic activity of cachectin as well as pre-clinical trials of TNF application in antitumor therapy.
Chciałowski
A
A
Kliniki Chorób Wewnetrznych i Pneumonologii Instytutu Medycyny Wewnetrznej Centralnego Szpitala Klinicznego WAM w Warszawie.
Targowski
T
T
Bajera
I
I
Jahnz-Rózyk
K
K
D000818:Animals; D006801:Humans; D008262:Macrophage Activation; D009369:Neoplasms / Q000628:therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use
D014409:Tumor Necrosis Factor-alpha