title: [Gastrointestinal damage in osteoarthritis patients].
abstract: Seventy-seven patients with symptomatic osteoarthritis of the hip and/or knee, with clinical indication for nonsteroidal anti-inflammatory drugs were studied. However, no patient was submitted to any anti-inflammatory medication seven days, prior the beginning of the study and did not complain of any gastrointestinal disease. Shortly before starting the anti-inflammatory drug therapy all patients were submitted to gastroduodenal endoscopy. This diagnostic procedure revealed that 54.6% of the patients presented at least one gastroduodenal damage, 22.1%, hyperemia, 3.9%, petechias, 23.4%, erosions and 5.2%, peptic ulcers. There results permitted to conclude that to identify and/or exclude damage of the gastrointestinal tract, data obtained in the anamnese are not sufficient. For these patients the endoscopic examination is a need. Anti-inflammatory therapy must be careful associated with dietetic orientation and the prescription of drugs to protect the gastrointestinal mucosa.
authors.affiliation: Serviço de Reumatologia, Faculdade de Medicina, Universidade de São Paulo.
authors.forename: R
authors.initials: R
authors.lastname: Fuller
authors.forename: E
authors.initials: E
authors.lastname: Hirose-Pastor
authors.forename: M
authors.initials: M
authors.lastname: Levy
authors.forename: S
authors.initials: S
authors.lastname: Zaterka
authors.forename: H B
authors.initials: HB
authors.lastname: Massuda
authors.forename: J N
authors.initials: JN
authors.lastname: Eisig
authors.forename: N H
authors.initials: NH
authors.lastname: Yoshinari
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000517:prevention & control; D006801:Humans; D006940:Hyperemia / Q000175:diagnosis; D008297:Male; D010003:Osteoarthritis / Q000188:drug therapy*; D010437:Peptic Ulcer / Q000188:drug therapy; D011693:Purpura / Q000175:diagnosis; D011706:Pyloric Antrum / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal