[Activation of the antibacterial properties and neutrophil myeloperoxidase and acid phosphatase in patients with unstable angina pectoris].
Neutrophils are very important in pathogenesis of ischemic disease. They take part in the biomorphology of thrombus and also in the damage of myocardium ischemia in a course of unstable angina pectoris. We evaluated the functional status of neutrophils in peripheral blood, by measurement of bactericidal activity and activity of granulocyte's enzymes: myeloperoxidase (MPO) and acid phosphatase in the patients with unstable angina pectoris. We studied a group of 43 people at the age from 34 to 74 years. The blood for investigation was obtained during the first five hours from the moment of hospitalization. The control group were 40 healthy people. The number of granulocytes was significantly higher in patients with unstable angina pectoris and granulocytes were metabolically activated which was shown in the bigger activity of granulocyte's enzymes like MPO and acid phosphatase than in the control group. The activation of neutrophils is developed by many factors in the course of unstable angina pectoris. They take part in the processes of thrombogenesis and thrombolysis and they are a very important origin for active oxygen metabolites, which are responsible for damage of myocardium ischemia.
Wysocka
J
J
Zakładu Laboratoryjnej Diagnostyki Pediatrycznej, Instytutu Diagnostyki Laboratoryjnej Akademii Medycznej w Białymstoku.
Stogowski
A
A
Mikołajczyk-Kwapisz
M
M
Malinowski
R
R
Turowski
D
D
D000135:Acid Phosphatase / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000150:complications / Q000382:microbiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology; D018375:Neutrophil Activation / Q000276:immunology*; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology; D009195:Peroxidase / Q000378:metabolism*
D009195:Peroxidase; D000135:Acid Phosphatase