title: [Disseminated intravascular coagulation in a case of adult onset Still's disease].
abstract: We report a 82-year-old woman with adult onset Still's disease (AOSD), who presented with high fever, skin rash, swollen axillary lymph nodes, accelerated erythrocyte sedimentation rate, leukocytosis, abnormal liver function tests, hypoalbuminemia, negative antinuclear antibody and rheumatoid factor, and lack of renal involvement. Disseminated intravascular coagulation (DIC) was also diagnosed on admission. An antipyretic relieved high fever and DIC soon improved. Three years later, AOSD relapsed accompanied by hypercoagulation and hyperfibrinolysis. The patient developed subdural hematoma and DIC due to a brain contusion. High titers of serum soluble adhesion molecules and soluble thrombomodulin were noted on the first episode of DIC. These findings indicated that endothelial cells were damaged in AOSD complicated by DIC.
authors.affiliation: Institute for Clinical Research, Kumamoto National Hospital.
authors.forename: I
authors.initials: I
authors.lastname: Sanada
authors.forename: F
authors.initials: F
authors.lastname: Kawano
authors.forename: A
authors.initials: A
authors.lastname: Tsukamoto
authors.forename: T
authors.initials: T
authors.lastname: Kiyokawa
authors.forename: T
authors.initials: T
authors.lastname: Shido
authors.forename: S
authors.initials: S
authors.lastname: Koga
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005260:Female; D006801:Humans; D016706:Still's Disease, Adult-Onset / Q000150:complications*