Iatrogenic central retinal vein occlusion and hyperviscosity associated with high-dose intravenous immunoglobulin administration.
OBJECTIVE
To describe a patient with iatrogenically induced central retinal vein occlusions secondary to serum hyperviscosity from intravenous immunoglobulin administration.


METHODS
Case report.


RESULTS
The patient developed bilateral central retinal vein occlusions in association with high-dose intravenous immunoglobulins. The central retinal vein occlusions resolved when the immunoglobulins were withheld and serum hyperviscosity decreased.


CONCLUSIONS
Administration of high-dose intravenous immunoglobulins can be associated with hyperviscosity syndrome manifested by central retinal vein occlusion.
Oh
K T
KT
Department of Ophthalmology, University of Iowa College of Medicine, USA.
Boldt
H C
HC
Danis
R P
RP
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001809:Blood Viscosity; D003586:Cytomegalovirus Infections / Q000628:therapy; D005654:Fundus Oculi; D006801:Humans; D007049:Iatrogenic Disease; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D011024:Pneumonia, Viral / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy; D012170:Retinal Vein Occlusion / Q000097:blood* / Q000209:etiology* / Q000503:physiopathology; D013577:Syndrome
D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous