title: Synthesis and antiplatelet effects of 2-amino-1,2-benzisothiazolin-3-one.
abstract: The synthesis of a new compound, 2-amino-1,2-benzisothiazolin-3-one, is described and its antiplatelet activity was studied. A good platelet aggregation inhibitory activity of the tested drug was clearly demonstrated both in vitro and ex vivo, presumably through an effect on arachidonic acid cascade or directly on thromboxane A2 (TXA2) receptors. An early and long lasting effect on bleeding time has also been observed. The results suggest that 2-amino-1,2-benzisothiazolin-3-one could be a potential antithrombotic agent.
authors.affiliation: Dipartimento Farmaceutico, Universita' di Parma, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Vicini
authors.forename: C
authors.initials: C
authors.lastname: Manotti
authors.forename: A
authors.initials: A
authors.lastname: Caretta
authors.forename: L
authors.initials: L
authors.lastname: Amoretti
mesh_terms: D000818:Animals; D001760:Bleeding Time; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits
chemical_list: D010975:Platelet Aggregation Inhibitors