Can drugs be designed?
Many examples are now emerging of the successful use of rational, structure-based methods in drug discovery. Of particular note is the development of imaginative NMR-based methods for rapid routes to ligand design. Our understanding of the chemistry underlying protein-ligand interactions, however, remains relatively poor and a major limitation in our ability to truly design drugs.
Hubbard
R E
RE
Department of Chemistry, University of York, Heslington, UK. rod@yorvic.york.ac.uk
D015195:Drug Design; D008024:Ligands; D008722:Methods; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000187:drug effects; D013329:Structure-Activity Relationship
D008024:Ligands; D011506:Proteins; D012313:RNA