Cardiovascular effects of estrogen: implications of the discovery of the estrogen receptor subtype beta.
In addition to the traditional estrogen receptor-alpha, a second estrogen receptor was recently discovered, namely estrogen receptor-beta. This review focuses on the cardiovascular significance of the differential ligand activation by these nuclear transcription factors and emphasizes the need for re-evaluation of all previously described estrogen receptor mediated estrogen and antiestrogen effects.
Foegh
M L
ML
Department of Surgery, Georgetown University Medical Center, Washington, DC, USA.
Ramwell
P W
PW
D000818:Animals; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D004967:Estrogens / Q000494:pharmacology* / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D004967:Estrogens; D011960:Receptors, Estrogen