Effects of ketamine sedation on glucose clearance, insulin secretion and counterregulatory hormone production in baboons (Papio hamadryas).
Since the effects of ketamine sedation seem to differ between subspecies of baboons, we assessed the endocrine response to an intravenous glucose tolerance test (IVGTT) in 12 hamadryas baboons. The first phase insulin secretion, basal insulin, and glucose levels, as well as the glucose clearance, were significantly lower in sedated baboons as compared to fully awake animals. Glucagon and cortisol were significantly higher, while growth hormone was lower during ketamine sedation. Papio hamadryas appears to be a promising pre-clinical model for the study of endocrine replacement therapy in insulin-dependent diabetes. However, the data obtained must be interpreted with the knowledge that the anesthetic employed to allow for testing of the animals does have an effect on the parameters described in this report.
Lehmann
R
R
Diabetes Research Institute, University of Miami, School of Medicine, FL, USA.
Wagner
J L
JL
Fernandez
L A
LA
Bourgoignie
J J
JJ
Ricordi
C
C
Alejandro
R
R
Kenyon
N S
NS
D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D005934:Glucagon / Q000032:analysis; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006854:Hydrocortisone / Q000032:analysis; D007328:Insulin / Q000378:metabolism*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D010215:Papio / Q000502:physiology*
D000778:Anesthetics, Dissociative; D007328:Insulin; D007649:Ketamine; D005934:Glucagon; D005947:Glucose; D006854:Hydrocortisone