Rubiadin, a new antioxidant from Rubia cordifolia.
Rubiadin, a dihydroxy anthraquinone, isolated from alcoholic extract of Rubia cordifolia, possesses potent antioxidant property. It prevents lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner. The per cent inhibition was more in the case of Fe2+ induced lipid peroxidation. The antioxidant property of the preparation has been found to be better than that of EDTA, Tris, mannitol, Vitamin E and p-benzoquinone.
Tripathi
Y B
YB
Department of Medicinal Chemistry, Banaras Hindu University, Varanasi, India.
Sharma
M
M
Manickam
M
M
D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D005978:Glutathione / Q000032:analysis / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains; D019666:Rubiaceae / Q000737:chemistry*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D000880:Anthraquinones; D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; C072500:rubiadin; D005978:Glutathione