title: Effect of biotin depletion on spike-wave seizures in the tottering mutant mouse.
abstract: Influence of depletion of biotin on spontaneously occurring spike-wave seizures in the tottering mutant mouse was tested by electrocorticographic recordings over three hours in five mice fed a biotin deficient diet. Frequency of seizures as well as percent of time with epileptic discharges were clearly lowered in the biotin deficient animals compared with eight mice of the same age under normal food (p < 0.01 in Wilcoxon's U-test).
authors.affiliation: Neurological Clinic, University of Heidelberg, Germany.
authors.forename: K H
authors.initials: KH
authors.lastname: Krause
authors.forename: J P
authors.initials: JP
authors.lastname: Bonjour
authors.forename: R
authors.initials: R
authors.lastname: Aichele-Wehrse
authors.forename: M
authors.initials: M
authors.lastname: Huck-Breiter
authors.forename: P
authors.initials: P
authors.lastname: Berlit
mesh_terms: D000818:Animals; D001710:Biotin / Q000172:deficiency*; D004569:Electroencephalography; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants; D012640:Seizures / Q000503:physiopathology*
chemical_list: D001710:Biotin