title: Comparative pulmonary absorption, distribution, and toxicity of copper gallium diselenide, copper indium diselenide, and cadmium telluride in Sprague-Dawley rats.
abstract: Copper gallium diselenide (CGS), copper indium diselenide (CIS), and cadmium telluride (CdTe) are novel compounds used in the photovoltaic and semiconductor industries. This study was conducted to characterize the relative toxicities of these compounds and to evaluate the pulmonary absorption and distribution after intratracheal instillation. Female Sprague-Dawley rats were administered a single equimolar dose (70 mM) of CGS (21 mg/kg), CIS (24 mg/kg), CdTe (17 mg/kg), or saline by intratracheal instillation. Bronchoalveolar lavage fluid (BALF) protein, fibronectin, inflammatory cells, lung hydroxyproline, and tissue distribution were measured 1, 3, 7, 14, and 28 days after instillation. Relative lung weights were significantly increased in CIS- and CdTe-treated rats at most time points. Inflammatory lesions in the lungs consisting of an influx of macrophages, lymphocytes, and PMNs were most severe in CdTe-treated rats, intermediate in CIS-treated rats, and minimal in rats receiving CGS. Hyperplasia of alveolar type 2 cells was present in CIS- and CdTe-treated rats and was greatest in CdTe-treated rats. Pulmonary interstitial fibrosis was observed in CdTe-treated rats at all time points. All three compounds caused marked increases in total BALF cell numbers, with the greatest increase observed in CIS-treated rats. BALF protein, fibronectin, and lung hydroxyproline were significantly increased in all treated animals and were highest in CdTe-treated animals. There was no apparent pulmonary absorption or tissue distribution of CGS. Indium levels increased in extrapulmonary tissues of CIS-treated rats, although Cu and Se levels remained unchanged. CdTe was absorbed from the lung to a greater extent than CGS and CIS. Cd and Te levels decreased in the lung and increased in extrapulmonary tissues. Of these compounds CdTe presents the greatest potential health risk because it causes severe pulmonary inflammation and fibrosis and because it is readily absorbed from the lung may potentially cause extrapulmonary toxicity.
authors.affiliation: National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Morgan
authors.forename: C J
authors.initials: CJ
authors.lastname: Shines
authors.forename: S P
authors.initials: SP
authors.lastname: Jeter
authors.forename: M E
authors.initials: ME
authors.lastname: Blazka
authors.forename: M R
authors.initials: MR
authors.lastname: Elwell
authors.forename: R E
authors.initials: RE
authors.lastname: Wilson
authors.forename: S M
authors.initials: SM
authors.lastname: Ward
authors.forename: H C
authors.initials: HC
authors.lastname: Price
authors.forename: P D
authors.initials: PD
authors.lastname: Moskowitz
mesh_terms: D000042:Absorption; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D019187:Cadmium Compounds / Q000378:metabolism* / Q000633:toxicity*; D003300:Copper / Q000378:metabolism* / Q000633:toxicity*; D005260:Female; D005353:Fibronectins / Q000737:chemistry; D005708:Gallium / Q000378:metabolism* / Q000633:toxicity*; D006909:Hydroxyproline / Q000378:metabolism; D007204:Indium / Q000378:metabolism* / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000378:metabolism* / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013691:Tellurium / Q000378:metabolism* / Q000633:toxicity*
chemical_list: D019187:Cadmium Compounds; D005353:Fibronectins; C101792:copper gallium diselenide; C101793:copper indium diselenide; D007204:Indium; D003300:Copper; D005708:Gallium; D012643:Selenium; D013691:Tellurium; D006909:Hydroxyproline; C028337:cadmium telluride