[Central obesity: relationship between conicity index and lipoprotein risk factors for coronary atherosclerosis].
In middle age men the relationship between biochemical and anthropometric parameters was studied associated with central obesity in order to evaluate the risk of coronary atherosclerosis. In 31 males of 30 to 65 years of age, "apparently healthy", we determined the percentile 50 (P50) for body fat percentage (PG), 26.8% (utilizing the skinfold thicknesses) and P75 of Conicity Index (IC), 1.26. Were selected 63 subjects with different values of PG and IC. IC, adjusted for BMI and PG, correlated with Cholesterol (CT), Triglycerides (TG), CT/C-HDL, C-LDL/C-HDL, Apolipoprotein B (ApoB), Apo B/C-HDL, (P < 0.01) in all cases), and cholesterol LDL (C-LDL) (P < 0.05). This population was divided in three groups: Group I, Control, N = 19, PG < = 27% and IC < 1.26; Group II, obese without Central Obesity Predominance (POC), N = 15, PG < or = 27% and IC < or = 1.26; Group III, N = 23, obese with POC, PG > 27% and IC < or = 1.26. We found that Group III vs Group II had: CT 242 +/- 35 vs 205 +/- 40 mg/dl (P < 0.01), C-LDL 165 +/- 41 vs 138 +/- 36 mg/dl (P < 0.05) and CT/C-HDL 6.0 +/- 1.2 VS 5.1 +/- 1.2 (p < 0.05) respectively. Group III vs I showed significant differences for all biochemical parameters and index studied with exception of C-HDL. In subjects with IC > 1.26 vs IC < = 1.26 increased the frequency of coronary risk factors and indicators: CT > or = 240 mg/dl, 59% vs 12% (P < 0.001); C-LDL > or = 160 mg/dl, 55% vs 18% (P < 0.001); Apo B > 120 mg/dl, 72% vs 26% (P < 0.001); CT/C-HDL > 4.5, 86% vs 53% (P < 0.01); C-LDL/C-HDL > 3.0, 86% vs 47% (P < 0.001); Apo B/C-HDL > 2.6, 72% vs 47% (P < 0.05). Our results suggest that the use of IC combined with lipoproteic factors and index will contribute to the detection of males at risk of coronary heart disease.
Coniglio
R I
RI
Centro de Investigaciones Biomédicas (CIBIOME), Viedma, Río Negro, Argentina.
Colombo
O
O
Vásquez
L
L
Salgueiro
A M
AM
Otero
J C
JC
Malaspina
M M
MM
D000328:Adult; D000368:Aged; D000886:Anthropometry; D001824:Body Constitution; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications*; D012307:Risk Factors
D008055:Lipids