[Cerebral sinus thrombosis: rapid test diagnosis by demonstration of increased plasma D-dimer levels (SimpliRED)].
OBJECTIVE
To perform an initial evaluation of the accuracy in detection of dural sinus and cerebral venous thrombosis using a bed-side test (SimpliRED).


METHODS
Early diagnosis and treatment of cerebral sinus thrombosis are important. A screening test to decide which patients should undergo further diagnostics would be valuable due to the low incidence. Six patients with MR proven cerebral sinus thrombosis underwent bed-side testing. The SimpliRED kit provides a clearly visible agglutination of the patient's red blood cells in the presence of elevated levels of the crosslinked fibrin derivative (D-dimer) in the sample.


RESULTS
The assay yielded a positive result in all six patients, even 56 days following the onset of clinical symptoms.


CONCLUSIONS
The sensitivity of SimpliRED in the detection of sinus venous thrombosis is not known. This assay, therefore, should be evaluated in a large prospective study. In addition, the capability of the test to assess the effect of and predict the duration of anticoagulation therapy should be considered.
Wildberger
J E
JE
Klinik für Radiologische Diagnostik, Universitätsklinikum der RWTH Aachen.
Mull
M
M
Kilbinger
M
M
Schön
S
S
Vorwerk
D
D
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006384:Hemagglutination; D006801:Humans; D008297:Male; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D012851:Sinus Thrombosis, Intracranial / Q000097:blood / Q000175:diagnosis*; D013997:Time Factors
D005338:Fibrin Fibrinogen Degradation Products; D011933:Reagent Kits, Diagnostic