title: Photoreceptor orientation and alignment in nasal fundus ectasia.
abstract: BACKGROUND
  We investigated whether Stiles-Crawford (SCE) functions, a measure of photoreceptor orientation and alignment, are disturbed in patients with nasal fundus ectasia (tilted disc; Fuch's coloboma without apparent pupillary involvement).
  
  
  METHODS
  SCE functions were obtained in three observers with nasal fundus ectasia, using psychophysical methods.
  
  
  RESULTS
  In all cases, disruption of photoreceptor alignment can be inferred. Results include location of the SCE peaks outside the pupil in the direction of the lesion, differential alignment, and reduction of the magnitude of SCE at various retinal loci (reduced curvature or p factor). Additional results obtained with the selective adaptation technique imply that receptor disarray (splaying) may be responsible for loss of retinal directional sensitivity.
  
  
  CONCLUSIONS
  From these results, it may be surmised that mechanical tractional forces can play a major role in defining photoreceptor orientation in the retina. Inferred anomalous photoreceptor alignment has heretofore not been specifically linked with Fuch's coloboma/tilted disc syndrome.
authors.affiliation: School of Optometry and Department of Physics and Astronomy, University of Missouri-St. Louis 63121-4499, USA.
authors.forename: V
authors.initials: V
authors.lastname: Lakshminarayanan
authors.forename: J E
authors.initials: JE
authors.lastname: Bailey
authors.forename: J M
authors.initials: JM
authors.lastname: Enoch
mesh_terms: D000221:Adaptation, Ocular / Q000502:physiology; D000293:Adolescent; D000328:Adult; D002829:Choroid / Q000002:abnormalities*; D003103:Coloboma / Q000503:physiopathology*; D003118:Color Perception / Q000502:physiology; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D009898:Optic Disk / Q000002:abnormalities*; D010786:Photoreceptor Cells / Q000503:physiopathology*; D058609:Visual Field Tests; D014794:Visual Fields