[Hormonal changes and secretion and stomach mucosal microstructure in the course of H. pylori in patients with duodenal ulcer].
We designed this study to follow exocrine, endocrine and microstructural changes in duodenal ulcer patients with H. pylori infection in the course and after quadruple eradication regimen. Quadruple therapy appeared to be highly effective method of both ulcer healing and H. pylori eradication. We observed enhanced regeneration of gastric mucosa in the course of treatment. Almost immediate decrease of plasma gastrin and increase of plasma somatostatin and EGF concentration in gastric juice were noticed.
Bobrzyński
A
A
II Katedry i Kliniki Chirurgii Ogólnej, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Gedliczka
O
O
Bielański
W
W
Stachura
J
J
Konturek
S
S
Budzyński
A
A
D000658:Amoxicillin / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D001729:Bismuth / Q000008:administration & dosage; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D004815:Epidermal Growth Factor / Q000032:analysis; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005755:Gastrins / Q000097:blood / Q000187:drug effects; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D009853:Omeprazole / Q000008:administration & dosage; D013004:Somatostatin / Q000097:blood / Q000187:drug effects
D000897:Anti-Ulcer Agents; D005755:Gastrins; D008795:Metronidazole; D013004:Somatostatin; D004815:Epidermal Growth Factor; D000658:Amoxicillin; D009853:Omeprazole; D001729:Bismuth