Cartilage protective agent (CPA) Ro 32-3555, a new matrix metalloproteinase inhibitor for the treatment of rheumatoid arthritis.
CPA was well tolerated at all dose levels (10-150 mg) following single oral dose administration to healthy male volunteers. There was no relationship between the intensity, duration and number of adverse events reported and the dose of CPA. There was a dose-related increase in exposure as measured by AUC0-infinity and Cmax. Administration of 10 mg CPA following food resulted in a delayed tmax, and a significant decrease in Cmax but not AUC0-infinity.
Wood
N D
ND
Roche Products Ltd, Welwyn Garden City, Hertfordshire, UK.
Aitken
M
M
Durston
S
S
Harris
S
S
McClelland
G R
GR
Sharp
S
S
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics*; D008297:Male; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D008875:Middle Aged; D011480:Protease Inhibitors / Q000627:therapeutic use*
D007093:Imidazoles; D011480:Protease Inhibitors; C106997:Ro 32-3555; D008666:Metalloendopeptidases