title: Interactions between H-2 and background genes modulate collagen induced arthritis in high (HI) and low (LI) antibody producer Biozzi mice.
abstract: The experimental arthritis (collagen induced arthritis, CIA) induced in mice by heterologous collagen of type II is mainly restricted to the H-2q or H-2r haplotypes. However, data including ours, strongly suggest that CIA is also under non MHC polygenic control. This point has been studied in new sub-strains of high (HI) and low (LI) Biozzi mice made congenic for H-2q and H-2s: the original Biozzi lines HI/H-2q and LI/H-2s and the new HI/H-2s, LI/H-2q congenic mice. 80% of the HI/H-2q mice develop severe chronic inflammatory symptoms with joint deformation and swelling soon after induction of the disease, while 60% of LI/H-2q counterpart develop at a later stage, deformation of joints with no or mild swelling. In the H-2s haplotype, considered to be non or weakly permissive to CIA, 40% of HI/H-2s have strong CIA symptoms; the LI/H-2s being totally refractory. Thus, if MHC products play a crucial role in selecting the arthritogenic epitope of CII; non H-2 genes strongly modulate the severity of experimental arthritis.
authors.affiliation: U131 INSERM, Clamart, France.
authors.forename: J
authors.initials: J
authors.lastname: Couderc
authors.forename: M F
authors.initials: MF
authors.lastname: Gille Perramant
authors.forename: Y
authors.initials: Y
authors.lastname: Bouthillier
authors.forename: J C
authors.initials: JC
authors.lastname: Mevel
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000235:genetics*; D001168:Arthritis / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D003094:Collagen / Q000276:immunology; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D007596:Joints / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D006183:H-2 Antigens; D003094:Collagen