[Bronchial asthma: pathogenetic mechanisms and genetic aspects].
At present there is a general consensus on the inflammatory nature of bronchial asthma. The main immunological features of the atopic state are represented by the ongoing expansion of Th2-like cells and production of IgE antibodies. IL-4 seems to represent the key factor for the differentiation of Th2-like cells, even though other cytokines have been recently proposed to play a some role. The possible genetic alterations which lead to the deregulated overexpression of IL-4 gene and of other genes of the same family in atopics are under active investigation. The existence of a polymorphism at level of IL-4 gene distal and proximal promoter has directly been shown. Even though IL-4 is required for the development and maintenance of atopic state, IL-5 certainly plays an essential role in the pathogenesis of bronchial inflammation in atopic, intrinsic and occupational asthma. On the basis of the findings emerged from new experimental models, it appears that there are different pathways by which T cell responses can develop bronchial eosinophilic inflammation but all the pathways have to lead to obligatory ongoing production of IL-5. The future research can be also addressed either to clarify the cytokines and/or other factors able to induce the differentiation and ongoing expansion of T cells prevalently producing IL-5, possibly involved in the pathogenesis of intrinsic asthma, either to understanding the nature of stimuli acting as etiologic factors. On the basis of the present acquisitions, IL-5 could represent the most important target of the new approaches to asthma therapy.
Ricci
M
M
Istituto di Medicina Interna ed Immunoallergologia, Università, Policlinico di Careggi, Firenze.
Matucci
A
A
Rossi
O
O
D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000235:genetics* / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D015847:Interleukin-4 / Q000235:genetics; D015848:Interleukin-5 / Q000235:genetics; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D016207:Cytokines; D015848:Interleukin-5; D015847:Interleukin-4; D007073:Immunoglobulin E