Neuronal survival: early dependence on Schwann cells.
Schwann cells fail to develop in mouse embryos lacking functional ErbB3 neuregulin receptors, and most sensory and motor neurons subsequently die in these mice. As ErbB3 acts cell autonomously in Schwann cell development but not in neuronal survival, neurons may depend on Schwann cells for survival.
Davies
A M
AM
School of Biological and Medical Sciences, Bute Medical Buildings, University of St. Andrews, St. Andrews, Fife KY16 9TS, Scotland. amd2@st-and.ac.uk
D000818:Animals; D002470:Cell Survival; D066246:ErbB Receptors / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology; D051379:Mice; D008959:Models, Neurological; D020880:Neuregulins; D009474:Neurons / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology; D020893:Receptor, ErbB-3; D066247:Receptor, ErbB-4; D012583:Schwann Cells / Q000502:physiology*
D066246:ErbB Receptors; D006023:Glycoproteins; D020880:Neuregulins; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; D066247:Receptor, ErbB-4; C587690:Erbb4 protein, mouse