title: [Tissue factor pathway inhibitor (TFPI) and its role in pathology].
abstract: Tissue factor pathway inhibitor (TFPI) is an important regulator of blood coagulation. It was described as antyconwertin (AC), extrinsic pathway inhibitor (EPI) and lipoprotein-associated coagulation inhibitor (LACI). TFPI is a glycoprotein, which is mainly synthesized by vascular endothelial cells. The concentration of this enzyme in plasma is low (100 ng/ml). TFPI inhibits activity of factor Xa and complex FVIIa/TF. Changes TFPI activity play an important role in coagulation disorders and presently the function of TFPI in various kinds of diseases is discussed.
authors.affiliation: Zakład Onkologii Akademii Medycznej w Białymstoku.
authors.forename: M
authors.initials: M
authors.lastname: Rucińska
authors.forename: M
authors.initials: M
authors.lastname: Gacko
authors.forename: Z
authors.initials: Z
authors.lastname: Skrzydlewski
mesh_terms: D000595:Amino Acid Sequence; D001777:Blood Coagulation / Q000502:physiology*; D001778:Blood Coagulation Disorders / Q000503:physiopathology; D065427:Factor Xa Inhibitors; D006801:Humans; D008074:Lipoproteins / Q000502:physiology*; D008969:Molecular Sequence Data
chemical_list: D065427:Factor Xa Inhibitors; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor