title: Creating novel enzymes by applied molecular evolution.
abstract: Recent molecular techniques have made it feasible to simulate evolutionary processes and apply in vitro selection to evolve enzymes with novel properties that may have potential benefits for medical and industrial applications. The characterization of such mutants has also provided new insights into how molecular structure determines enzyme function.
authors.affiliation: The Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington School of Medicine, Box 357705, Seattle, WA 98195-7705, USA.
authors.forename: A
authors.initials: A
authors.lastname: Skandalis
authors.forename: L P
authors.initials: LP
authors.lastname: Encell
authors.forename: L A
authors.initials: LA
authors.lastname: Loeb
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019020:Directed Molecular Evolution; D004798:Enzymes / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D004798:Enzymes