Glycosylated hemoglobin and fetal growth in normal, gestational and insulin dependent diabetes mellitus pregnancies.
Aims of the study were: evaluation of HbA1c levels in the peripheral blood of pregnant women with insulin dependent diabetes, gestational diabetes, glucose intolerance, and healthy pregnant controls; implications of HbA1c concentration on detection and the control of women with impaired carbohydrate metabolism in pregnancy; comparison of HbA1c levels with appearance of miscarriages, and premature deliveries; comparison of weight gain during pregnancy to HbA1c levels; comparison of difference from ideal body weight with HbA1c in diabetic pregnant women; comparison of neonatal birth weight and HbA1c levels. 290 pregnant women were enrolled to the study. The highest value of HbA1c was in the group IDDM pregnant women (7.7% +/- 1.8%), and the lowest value of HbA1c was in the control group (4.1% +/- 0.5%). Statistically significant coefficients were found between HbA1c and weight gain during pregnancy, between weight deviation from ideal body weight and HbA1c (r = 0.54 and r = 0.48 respectively); and between newborns weight and HbA1c (r = 0.51). Well regulated glycemia and intensive pregnancy follow-up of diabetic women reduces stillbirths, neonatal complications and neonatal macrosomia incidence.
Djelmis
J
J
Department of OB/GYN, Medical School University of Zagreb, Croatia.
Blajić
J
J
Buković
D
D
Pfeifer
D
D
Ivanisević
M
M
Kendić
S
S
Votava-Raić
A
A
D000328:Adult; D016022:Case-Control Studies; D017523:Croatia / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D016014:Linear Models; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*
D006442:Glycated Hemoglobin