title: Pax-6, eyes absent, and Prox 1 in eye development.
abstract: Eyes in different systematic groups including arthropods, molluscs and vertebrates probably have a common evolutionary origin. As a consequence of this, related genes are used for regulation of the early steps of eye development in different organisms. In this review, I briefly summarize data on three gene families which might be essential for eye development across species: Pax-6/eyeless, Eya/eyes absent and Prox/prospero with emphasis on our contribution here. Mechanisms of eye formation and the generation of different types of eyes in the course of evolution are discussed.
authors.affiliation: Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, MD 20892-2730, USA. tomarev@fcrfv1.ncifcrf.gov
authors.forename: S I
authors.initials: SI
authors.lastname: Tomarev
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D029721:Drosophila Proteins; D005123:Eye / Q000254:growth & development*; D005136:Eye Proteins / Q000235:genetics* / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D005809:Genes, Regulator; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology; D025521:Tumor Suppressor Proteins; D000098551:Prospero-Related Homeobox 1 Protein
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C092694:eya protein, Drosophila; D000098551:Prospero-Related Homeobox 1 Protein