Reduction of cyclosporine dosage with ketoconazole in a patient with birdshot retinochoroidopathy.
OBJECTIVE
To report the successful reduction of cyclosporine dosage with adjunctive ketoconazole in a patient with birdshot retinochoriodopathy.


METHODS
Case report.


RESULTS
A 55-year-old woman treated with cyclosporine for birdshot retinochoroidopathy had ketoconazole (200 mg/day) added to her medical regimen. Her cyclosporine dosage was reduced to 40 mg per day from 200 mg per day, an 80% reduction. No toxic effect was observed during 12 months of follow-up nor was there progression of the birdshot retinochoroidopathy.


CONCLUSIONS
Cyclosporine dosage may be reduced considerably in patients with uveitis who use adjunctive ketoconazole. The regimen appears to be safe and efficacious.
Silverstein
B E
BE
Francis I. Proctor Foundation, University of California, San Francisco Medical Center 94122-0944, USA.
Wong
I G
IG
D017024:Chemotherapy, Adjuvant; D015862:Choroid Diseases / Q000188:drug therapy* / Q000503:physiopathology; D016572:Cyclosporine / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D007654:Ketoconazole / Q000627:therapeutic use*; D008875:Middle Aged; D012164:Retinal Diseases / Q000188:drug therapy* / Q000503:physiopathology; D012449:Safety; D015866:Uveitis, Posterior / Q000188:drug therapy / Q000503:physiopathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D007654:Ketoconazole