title: The chromosomal effect of birchen dust as determined by the micronucleus test.
abstract: In a wood processing factory, the measured air concentration of birchen dust was 1.26 +/- 0.41 mg/m3, and the micronucleus frequency of peripheral blood lymphocytes in 83 workers exposed to wood dust was 1.13 +/- 2.83/1000, which was significantly higher (P < 0.01) than that of control group (0.51 +/- 1.41/1000). The number of exposed workers with positive micronucleus test was 9.6%, which was higher than that of control group (4.5%), but the difference was not significant (P > 0.05). The micronucleus test in mice treated with water extracts of unsteamed and unbaked birchen dust showed that the micronucleus frequencies in all treated groups were significantly higher than that of control group (P < 0.01) and there was also a dose response correlation (r = 0.96, P < 0.0005). The results of steamed and baked birchen dust extracts were significantly lower than those of the unsteamed and unbaked ones at the same doses (P < 0.001). This suggests that when the birchen dust is steamed at the temperature of 100 degrees C for 24 h or baked at the temperature of 80 degrees C, its inducing effect in micronucleus test could be lowered.
authors.affiliation: Department of Occupational Health, Capital University of Medical Sciences, Beijing, China.
authors.forename: Z C
authors.initials: ZC
authors.lastname: Jiang
authors.forename: Y L
authors.initials: YL
authors.lastname: Su
authors.forename: Y F
authors.initials: YF
authors.lastname: Deng
authors.forename: W
authors.initials: W
authors.lastname: Sun
authors.forename: W C
authors.initials: WC
authors.lastname: Liu
authors.forename: D M
authors.initials: DM
authors.lastname: Wei
authors.forename: J Y
authors.initials: JY
authors.lastname: Yan
authors.forename: Y L
authors.initials: YL
authors.lastname: Yao
mesh_terms: D000328:Adult; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D015331:Cohort Studies; D004391:Dust; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D008875:Middle Aged; D016273:Occupational Exposure; D013249:Sternum; D013601:T-Lymphocytes / Q000648:ultrastructure*; D013997:Time Factors; D014197:Trees; D014934:Wood
chemical_list: D004391:Dust