title: Fetal calf serum decreases CYP3A induction in rat but not in dog or human hepatocyte cultures.
authors.affiliation: Department of Medicine, University of Aberdeen, UK.
authors.forename: F C
authors.initials: FC
authors.lastname: Jackson
authors.forename: R J
authors.initials: RJ
authors.lastname: Chenery
authors.forename: G M
authors.initials: GM
authors.lastname: Hawksworth
mesh_terms: D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D001769:Blood; D002417:Cattle; D002478:Cells, Cultured; D003470:Culture Media; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D003907:Dexamethasone / Q000494:pharmacology; D004285:Dogs; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005333:Fetus; D006801:Humans; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D010089:Oxidoreductases, N-Demethylating / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012293:Rifampin / Q000494:pharmacology
chemical_list: D003470:Culture Media; D003907:Dexamethasone; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating; D012293:Rifampin