title: Donor left ventricular hypertrophy increases risk for early graft failure.
abstract: A review of factors contributing to early mortality after cardiac transplantation revealed that up to 25% of deaths were due to primary graft dysfunction unrelated to rejection or infection. In light of this finding, evaluation of a donor heart with regard to its suitability for transplantation takes on added importance. In an effort to screen the suitability of donor hearts in the region covered by the Northwest Organ Procurement Agency (USA), all donors are evaluated by two-dimensional transthoracic echocardiography as part of the initial evaluation. A total of 110 donor echocardiograms were reviewed and an attempt was made to correlate the 30-day outcome with the parameters measured. An unexpected finding was that the presence of left ventricular hypertrophy in the donor heart was associated with an increase in the incidence of donor heart dysfunction compared with donors with normal echocardiographic profiles (33% vs 3%, P = 0.007).
authors.affiliation: Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA.
authors.forename: S
authors.initials: S
authors.lastname: Aziz
authors.forename: L A
authors.initials: LA
authors.lastname: Soine
authors.forename: S L
authors.initials: SL
authors.lastname: Lewis
authors.forename: A P
authors.initials: AP
authors.lastname: Kruse
authors.forename: W C
authors.initials: WC
authors.lastname: Levy
authors.forename: K M
authors.initials: KM
authors.lastname: Wehe
authors.forename: D P
authors.initials: DP
authors.lastname: Fishbien
authors.forename: M D
authors.initials: MD
authors.lastname: Allen
mesh_terms: D000328:Adult; D004452:Echocardiography; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology*; D006085:Graft Survival / Q000502:physiology; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors; D017211:Treatment Failure