[The effect of the preliminary intake of mineral waters in acute alcoholic intoxication (an experimental study)].
101 male Wistar rats (body mass 180-200 g) received a single dose of ethanol in two concentrations--96% and 30%. High ethanol concentrations produced a direct damage to gastric and duodenal mucosa. 30% ethanol inhibited secretion of glucagon, insulin and aldosterone. This inhibition rapidly changes for the hormones rise in the blood. Hydrocortisone was high over the experiment. Previous intake of mineral water prevents damage to the gastroduodenal mucosa induced by 96% ethanol and modifies the hormonal response provoked by 30% ethanol as evident from reduced expression of the two phases.
Polushina
N D
ND
Frolkov
V K
VK
D000435:Alcoholic Intoxication / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004386:Duodenum / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage / Q000506:poisoning; D005753:Gastric Mucosa / Q000187:drug effects; D006728:Hormones / Q000097:blood; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D008900:Mineral Waters / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D006728:Hormones; D008900:Mineral Waters; D000431:Ethanol