title: Role of C-reactive protein in acute lung injury.
abstract: Excessive inflammation caused by unregulated inflammatory processes can lead to disease. One example of this is seen in acute lung injury in which an individual is unable to regulate an inflammatory response in the lungs, with the net effect of self-induced tissue injury and loss of organ function. The acute-phase reactant, C-reactive protein, inhibits acute lung injury in animal models and, in this regard, acts as a major anti-inflammatory agent. Therefore, understanding the mechanism by which C-reactive protein elicits this inhibitory effect may provide important information about the design of therapeutic agents for the prevention or treatment of inflammation-mediated tissue injury and resultant loss of organ function.
authors.affiliation: St Louis University School of Medicine, MO 63110-0250, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Heuertz
authors.forename: R O
authors.initials: RO
authors.lastname: Webster
mesh_terms: D000208:Acute Disease; D000818:Animals; D002097:C-Reactive Protein / Q000276:immunology*; D002199:Capillary Permeability; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation; D008168:Lung / Q000276:immunology; D055370:Lung Injury; D009504:Neutrophils / Q000276:immunology; D010455:Peptides / Q000378:metabolism; D012127:Respiratory Distress Syndrome, Newborn
chemical_list: D010455:Peptides; D002097:C-Reactive Protein