title: Post immunization Hib antigen detection in the CSF of a patient with meningococcal meningitis.
abstract: We report a case of meningococcal meningitis where the cerebrospinal fluid was negative for Neisseria meningitidis but positive for Haemophilus influenzae type b by rapid antigen detection test. We believe that this was due to prior immunization with Haemophilus influenzae type b vaccine. We recommend caution in interpretation of the rapid antigen detection tests especially in patients who had been vaccinated against organisms screened by these tests.
authors.affiliation: Department of Pediatrics, American University of Beirut, Lebanon.
authors.forename: A N
authors.initials: AN
authors.lastname: Samaha
authors.forename: G F
authors.initials: GF
authors.lastname: Araj
authors.forename: S M
authors.initials: SM
authors.lastname: Mroueh
mesh_terms: D000942:Antigens, Bacterial / Q000134:cerebrospinal fluid*; D002443:Ceftriaxone / Q000008:administration & dosage; D002511:Cephalosporins / Q000008:administration & dosage; D002555:Cerebrospinal Fluid / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D018073:Haemophilus Vaccines / Q000276:immunology*; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D007223:Infant; D007841:Latex Fixation Tests; D008585:Meningitis, Meningococcal / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000188:drug therapy; D009345:Neisseria meningitidis / Q000302:isolation & purification; D013997:Time Factors; D014611:Vaccination
chemical_list: D000942:Antigens, Bacterial; D002511:Cephalosporins; D018073:Haemophilus Vaccines; D002443:Ceftriaxone