Regulation of hepatic thrombopoietin production by portal hemodynamics in liver cirrhosis.
OBJECTIVE
This study was designed to clarify how thrombopoietin (TPO) functions in and, to some extent, causes thrombocytopenia complicating liver cirrhosis and portal hypertension.


METHODS
Our study population consisted of 19 cirrhotic and six noncirrhotic patients who underwent percutaneous transhepatic portography (PTP) and hepatic venography.


RESULTS
The platelet counts of the cirrhotic patients were significantly lower than those of the noncirrhotic patients (8.7 +/- 4.1 vs 17.4 +/- 7 x 10(4)/microl; p < 0.01). The flow direction in the splenic vein was confirmed by PTP. Ten hepatofugal and nine hepatopetal flow directions in the splenic vein were noted among the cirrhotics. The hepatofugal group showed lower portal venous pressure (20 +/- 10 vs 32 +/- 4 cm H2O; p < 0.01) than the hepatopetal group and had a higher incidence of hepatic encephalopathy (six of 10 vs zero of nine; p < 0.01). The hepatic vein-portal difference in TPO did not differ substantially between the cirrhotics and noncirrhotics (0.12 +/- 0.04 vs 0.24 +/- 0.07 fmol/ml). Comparisons of this value among the three groups showed the TPO difference to be lowest in the hepatofugal group (hepatofugal: 0.04 +/- 0.03, hepatopetal: 0.21 +/- 0.07, noncirrhotic: 0.24 +/- 0.07; p < 0.05).


CONCLUSIONS
Our findings suggest that TPO production in the cirrhotic liver is regulated by the portal blood supply to the liver. Thus, portal hemodynamics may play a critical role in the development of thrombocytopenia.
Sezai
S
S
Division of Gastroenterology, Kanto NTT Hospital, Tokyo, Japan.
Kamisaka
K
K
Ikegami
F
F
Usuki
K
K
Urabe
A
A
Tahara
T
T
Kato
T
T
Miyazaki
H
H
D000368:Aged; D003627:Data Interpretation, Statistical; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006439:Hemodynamics; D006501:Hepatic Encephalopathy / Q000209:etiology; D006503:Hepatic Veins / Q000000981:diagnostic imaging / Q000502:physiology; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D010976:Platelet Count; D011168:Portal System / Q000503:physiopathology*; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000502:physiology; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology*; D013926:Thrombopoietin / Q000097:blood / Q000502:physiology*; D014690:Venous Pressure
D013926:Thrombopoietin