[Psoriasis in the animal model].
Co-existing inflammation and epidermal hyperproliferation characteristic for psoriasis have been shown to be reproducible in several animal models utilizing a variety of different strategies. These models highlight some points of the multicausal pathogenesis of psoriasis. Based on observations made in the animal models, a hypothesis is proposed for the pathogenesis of psoriasis, the elements of which can be tested in a recently established xenogeneic transplantation model.
Boehncke
W H
WH
Zentrum der Dermatologie und Venerologie, Johann-Wolfgang-Goethe-Universität, Frankfurt/Main.
D000818:Animals; D004195:Disease Models, Animal; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D008822:Mice, Transgenic; D011565:Psoriasis / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D012867:Skin / Q000473:pathology; D014183:Transplantation, Heterologous
D015796:HLA-B27 Antigen