Hemophagocytic syndrome and T-cell lymphoma after kidney transplantation: a case report.
Lymphoma in immunocompromised transplant patients is a feared cause of morbidity and mortality. Superimposed on the lymphoma and the transplantation immunosuppression is a rare condition: hemophagocytic syndrome (HS). HS is characterized by fever, hepatosplenomegaly and lymphadenopathy, skin rashes, jaundice, coagulopathy, and phagocytosis of blood elements with pancytopenia. Here we describe a rare but fatal case of a kidney transplant patient who developed T-cell lymphoma and HS, without evidence of EBV replication. A short review of the diagnosis, treatment, and prognosis of HS is given.
Peeters
P
P
Department of Nephrology, University Hospital, Free University Brussels, Belgium.
Sennesael
J
J
De Raeve
H
H
De Waele
M
M
Verbeelen
D
D
D017809:Fatal Outcome; D015616:Histiocytosis, Non-Langerhans-Cell / Q000097:blood / Q000150:complications* / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000209:etiology*; D008297:Male; D008875:Middle Aged