[Gm and Km allotypes in a Chilean urban population sample].
BACKGROUND
The knowledge of the genic structure of a population is of great importance for evolutive studies.


OBJECTIVE
To estimate in a Chilean population sample from the low-middle and low socioeconomic strata of Santiago, haplotypes and allele frequencies for Gm and Km loci.


METHODS
The sample included 460 controls of a case-control study of typhoid fever.


RESULTS
The G1m-G2m-G3m most frequent haplotypes were: za;..;g or 1,17;(-);21 = 0.4493;fn;b or 3;23;5,13 = 0.2522; f-,..;b or 3;(-);5,13 = 0.1389; zax;..;g or 1,2,17;(-);21 = 0.0685; za;..;b or 1,17;(-);5,13 = 0.0454; za;n;g or 1,17;23;21 = 0.0207; f;..;g or 3;(-);21 = 0.0129. The frequencies of Km alleles were 0.2391 and 0.7609 for Km1 and Km3 respectively.


CONCLUSIONS
These frequencies are within those found in Amerindian and Caucasian populations as expected from the origin of the Chilean population. Gm haplotypes did not differ from Hardy-Weinberg equilibrium, while a significant lack of homozygous Km1/km1 was found in Km.
Arcos-Burgos
M
M
Departamento de Biología Celular y Genética, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Valenzuela
C Y
CY
Herrera
P J
PJ
Pandey
J P
JP
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002677:Chile; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D008297:Male; D010641:Phenotype; D014435:Typhoid Fever / Q000235:genetics*; D014505:Urban Population
D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes