title: Cloning of a T-cell receptor beta-chain enhancer binding protein.
abstract: Several eukaryotic DNA binding proteins have been isolated by screening lambda expression libraries with DNA probes containing their binding site. This strategy has been employed to isolate clones of the factor that interacts with the T-cell receptor beta-chain enhancer motif. A cDNA clone encoding a protein similar to YB-1 has been isolated with this. It seems probable that this protein YB, might interact with other proteins and regulate the transcription of the T-cell receptor beta-chain gene.
authors.affiliation: La Jolla Institute for Allergy and Immunology, Department of Molecular Biology, San Diego, CA 92122, USA. jgaikwad@mail.db.uth.tmc.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Gaikwad
authors.forename: A
authors.initials: A
authors.lastname: Fotedar
mesh_terms: D022762:CCAAT-Enhancer-Binding Proteins; D003001:Cloning, Molecular; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D006801:Humans; D051839:NFI Transcription Factors; D009687:Nuclear Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D014157:Transcription Factors; D051840:Y-Box-Binding Protein 1
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D051839:NFI Transcription Factors; D009687:Nuclear Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D014157:Transcription Factors; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human