title: Osteosarcoma of the larynx.
abstract: About 11,600 cases of laryngeal cancer were reported in the United States in 1995, accounting for 1% of all reported cancers. Fewer than 1% of laryngeal cancers are sarcomas, osteosarcoma being the rarest type. Twelve cases of laryngeal osteosarcoma have been cited in the literature. A 47-year-old man presented with hoarseness following a benign vocal polypectomy. The entire larynx appeared swollen, although both vocal folds moved well. Biopsies did not reveal pathologic tissue. Computed tomographic imaging revealed a destructive, expansile lesion of the thyroid cartilage. A computed tomography-guided biopsy of this cartilage revealed a high-grade sarcoma. Laryngeal osteosarcoma was diagnosed following total laryngectomy. Laryngeal osteosarcoma is a highly malignant neoplasm with early hematogenous spread. Survival statistics for peripheral osteosarcoma are poor. Limited experience reveals that a combination of surgery and radiotherapy with adjuvant chemotherapy can offer some palliation. The literature and published cases of laryngeal osteosarcoma are reviewed.
authors.affiliation: Department of Otolaryngology, Long Island Jewish Medical Center, New Hyde Park, New York, USA.
authors.forename: D
authors.initials: D
authors.lastname: Myssiorek
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: P
authors.initials: P
authors.lastname: Wasserman
authors.forename: O
authors.initials: O
authors.lastname: Rofeim
mesh_terms: D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D010166:Palliative Care; D011859:Radiography