title: Treatment with rhG-CSF for osteomyelitis in a patient with p47-phox-deficient chronic granulomatous disease.
abstract: A 24-year-old woman with osteomyelitis was diagnosed as having p47-phox-deficient chronic granulomatous disease (CGD). The patient showed a marked deficiency of p47-phox, which is very rare in Japan. As the clinical response to various antibiotics including sulfamethoxazole-trimethoprim was not satisfactory, we added recombinant human granulocyte colony-stimulating factor (rhG-CSF) to the treatment protocol. We report the beneficial clinical course of the patient, together with the effect of rhG-CSF on the granulocyte function, and the present report indicates that rhG-CSF is useful for the treatment of antibiotic-resistant infection in the variant type of p47-phox-defective CGD.
authors.affiliation: Department of Internal Medicine, Hirakata City Hospital, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Isotani
authors.forename: Y
authors.initials: Y
authors.lastname: Fukumoto
authors.forename: H
authors.initials: H
authors.lastname: Kawamura
authors.forename: M
authors.initials: M
authors.lastname: Sasada
authors.forename: K
authors.initials: K
authors.lastname: Hattori
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D019255:NADPH Oxidases; D010019:Osteomyelitis / Q000150:complications* / Q000188:drug therapy*; D010750:Phosphoproteins / Q000172:deficiency* / Q000235:genetics; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D010750:Phosphoproteins; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D019255:NADPH Oxidases; C060505:neutrophil cytosolic factor 1