A uterine choriocarcinoma in a virgin Donryu rat.
A uterine choriocarcinoma was found in a 49-wk-old virgin Donryu rat given intrauterine administration of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). The tumor was macroscopically present as a bloody cystic mass and microscopically composed of 2 kinds of cells: small basophilic cells similar to cytotrophoblasts in the rat placenta and large cells with big nuclei resembling giant trophoblasts. The giant cells were positive for 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), although immunohistochemical examination was negative or nonspecific for chorionic gonadotrophins, including beta human chorionic gonadotrophin (beta hCG), human placental lactogen (hPL), and placental glycoprotein (SP-1), or for placental alkaline phosphatase (ALP). However, the animal exhibited a slight mammotropic status. The results thus suggest a choriocarcinoma nature for this uterine tumor and that the tumor cells secrete a weakly mammotrophic hormone.
Yoshida
M
M
Department of Pathology, Sasaki Institute, Tokyo, Japan. maekawa@sasaki.or.jp
Shiraki
K
K
Kudoh
K
K
Ando-Lu
J
J
Takahashi
M
M
Maekawa
A
A
D000818:Animals; D002273:Carcinogens; D002822:Choriocarcinoma / Q000139:chemically induced / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051381:Rats; D011919:Rats, Inbred Strains; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000737:chemistry / Q000473:pathology*
D002273:Carcinogens