title: Molecular conjugate-mediated gene transfer into isolated human and transplanted rat kidneys.
abstract: Technically, renal transplantation has been feasible for over four decades. However, immunological injury to the transplanted kidney continues to be the leading cause of graft loss. While current immunosuppressive protocols yield a 1-year graft survival of > 90%, the trade off is increased risks from nephrotoxicity to manifestations of long-term immunosuppression. We have developed techniques which would allow genetic manipulation of the donor kidney while utilizing current procurement and preservation protocols.
authors.affiliation: Department of Surgery, School of Medicine, University of Alabama at Birmingham 35294, USA. stephen.zeigler@ccc.uab.edu
authors.forename: S T
authors.initials: ST
authors.lastname: Zeigler
authors.forename: J D
authors.initials: JD
authors.lastname: Kerby
authors.forename: J A
authors.initials: JA
authors.lastname: Thompson
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy; D007668:Kidney / Q000378:metabolism*; D016030:Kidney Transplantation; D051381:Rats; D014021:Tissue Preservation