title: Carotid plaque characteristics and presenting symptom.
abstract: BACKGROUND
  The importance of identifying features of carotid artery disease, in addition to degree of stenosis, which predict subsequent stroke is becoming increasingly clear. This study assessed the relationship between carotid plaque characteristics and presenting symptoms.
  
  
  METHODS
  Some 285 symptomatic (transient ischaemic attack (TIA) 127, amaurosis fugax 58, transient stroke 15, established stroke 55, progressive stroke 11, crescendo TIA 19) and 65 asymptomatic patients were studied with colour-flow duplex imaging. All patients had 60-99 per cent internal carotid stenosis. Carotid plaque morphology (classified according to Gray-Weale) and plaque surface features were assessed.
  
  
  RESULTS
  Plaque types I and II were more common in symptomatic patients (83 per cent versus 44 per cent; P < 0.0001). Plaque surface was classified as smooth (34 per cent), irregular (44 per cent) or ulcerated (22 per cent). Ulceration was also more common in symptomatic patients (23 versus 14 per cent; P = 0.04). In symptomatic patients there was no association between presenting symptom and plaque morphology or surface features (P = 0.9 and P = 0.8 respectively). On multiple regression analysis plaque morphology did not distinguish between patients who presents with stroke without warning and other symptomatic patients (who had TIA, amaurosis fugax, crescendo TIA or stroke with warning).
  
  
  CONCLUSIONS
  There was an association between echolucent type I and II carotid plaques and the presence of symptoms but not their type. Plaque morphology was not characteristic in a subgroup of patients who had stroke without warning. Further prospective study of plaque morphology in asymptomatic patients might help identify high-risk groups.
authors.affiliation: Department of Surgery, Charing Cross and Westminster Medical School, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Golledge
authors.forename: R
authors.initials: R
authors.lastname: Cuming
authors.forename: M
authors.initials: M
authors.lastname: Ellis
authors.forename: A H
authors.initials: AH
authors.lastname: Davies
authors.forename: R M
authors.initials: RM
authors.lastname: Greenhalgh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017536:Carotid Artery, Common; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D018615:Ultrasonography, Doppler, Color; D018616:Ultrasonography, Doppler, Duplex