White blood cell depletion of single-donor platelet preparations using the new adsorption filter biofil P 10 BBS.
A newly developed adsorption filter has been evaluated for the removal of white blood cells (WBC) from platelet concentrates obtained by the blood cell separators Fenwal CS 3000 Plus (CS) and Haemonetics PCS Plus (H). WBC mean removal rate was 99.82 +/- 0.21% (H) and 99.58 +/- 0.01% (CS) with a mean WBC yield of (13.68 +/- 21.52) x 10(5) (H) and (0.20 +/- 0.23) x 10(5) (CS). Platelet recovery was 86.11 +/- 6.74% (H) and 83.04 +/- 5.59% (CS). Morphology, integrity and in vitro function parameters were not influenced by the filtration.
Müller
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Institute of Transfusion Medicine, University Clinics Essen, Germany.
D000327:Adsorption; D001782:Blood Donors; D005374:Filtration / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D010983:Plateletpheresis / Q000295:instrumentation* / Q000379:methods