Linkage mapping of rat chromosome markers generated from chromosome-sorted DNA.
Ninety-one new rat microsatellite chromosome markers were generated through screening chromosome-sorted DNA libraries. Of the 91 markers, 29 have been mapped to various rat chromosomes. Because of a lack of suitable polymorphisms among the appropriate rat strains of our interest, the remaining 62 markers are still unassigned, but are likely to be useful for genotyping different rat strains employed to study a wide range of genetic traits other than blood pressure. With these new markers, two genes, encoding alpha 2 adrenergic receptor, class II and gastric H,K-ATPase beta subunit, were mapped to regions on rat Chromosomes (Chrs) 1 and 16 respectively.
Deng
A Y
AY
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699-0008, USA.
Smith-Mensah
W H
WH
Hoebee
B
B
Garrett
M
M
Rapp
J P
JP
D000818:Animals; D002874:Chromosome Mapping; D004247:DNA; D008040:Genetic Linkage; D017506:H(+)-K(+)-Exchanging ATPase / Q000235:genetics*; D018895:Microsatellite Repeats; D051381:Rats; D011919:Rats, Inbred Strains; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*
D018341:Receptors, Adrenergic, alpha-2; D004247:DNA; D017506:H(+)-K(+)-Exchanging ATPase