Stroke and cholesterol: 'enigma variations'?
The relationship of raised serum cholesterol to coronary atherosclerosis, the main pathophysiological substrate for most ischaemic myocardial events, is clear. Strokes have a more complex aetiology. Hypertension and smoking are strong risk factors for stroke, and their elimination is effective in stroke prevention, but cholesterol has been regarded historically as a poor predictor of stroke incidence. The reasons for this are analysed and the relevance of serum cholesterol to stroke prevention discussed.
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St George's Hospital, London.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001161:Arteriosclerosis / Q000150:complications; D002561:Cerebrovascular Disorders / Q000145:classification / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012307:Risk Factors