title: Acute retinal necrosis late in the second trimester.
abstract: OBJECTIVE
  To report treatment of a patient with acute retinal necrosis during pregnancy.
  
  
  METHODS
  A 24-year-old woman in her twenty-third week of gestation was diagnosed with acute retinal necrosis. A combination of acyclovir and interferon therapy was started at 25 weeks. Pars plana vitrectomy was performed during the 26th week of gestation.
  
  
  RESULTS
  The necrotizing retina became gliotic within 3 weeks of surgery. The patient's visual acuity improved to LE, 20/40. A healthy baby was delivered at 39 weeks of gestation.
  
  
  CONCLUSIONS
  Combination therapy of acyclovir and interferon followed by surgery partially restored the patient's vision without affecting fetal development.
authors.affiliation: Department of Ophthalmology, Osaka City University Medical School, Japan. shirakik@msci.med.osaka-cu.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Shiraki
authors.forename: M
authors.initials: M
authors.lastname: Moriwaki
authors.forename: S
authors.initials: S
authors.lastname: Ataka
authors.forename: K
authors.initials: K
authors.lastname: Henmi
authors.forename: T
authors.initials: T
authors.lastname: Miki
authors.forename: Y
authors.initials: Y
authors.lastname: Kanaoka
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004279:DNA, Viral / Q000032:analysis; D004359:Drug Therapy, Combination; D015828:Eye Infections, Viral / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D005260:Female; D005865:Gestational Age; D006561:Herpes Simplex / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D015882:Retinal Necrosis Syndrome, Acute / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy; D014822:Vitreous Body / Q000821:virology
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D016899:Interferon-beta; D000212:Acyclovir