title: Rhabdomyolysis in autosomal dominant progressive external ophthalmoplegia.
abstract: Multiple mtDNA deletions have been reported to be a cause of inherited recurrent myoglobinuria. We report a 57-year-old man with autosomal dominant progressive external ophthalmoplegia and multiple mtDNA deletions who developed acute rhabdomyolysis provoked by alcohol. A repeated alcohol intake resulted in a 57-fold increase in serum myoglobin. Patients with mitochondrial myopathy and multiple mtDNA deletions, regardless of associated phenotype and mode of inheritance, may develop rhabdomyolysis.
authors.affiliation: Department of Neurology, Uppsala University Hospital, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Melberg
authors.forename: E
authors.initials: E
authors.lastname: Holme
authors.forename: A
authors.initials: A
authors.lastname: Oldfors
authors.forename: P O
authors.initials: PO
authors.lastname: Lundberg
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D002492:Central Nervous System Depressants / Q000009:adverse effects*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004272:DNA, Mitochondrial / Q000235:genetics; D000431:Ethanol / Q000009:adverse effects*; D017353:Gene Deletion; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008875:Middle Aged; D009212:Myoglobinuria / Q000097:blood / Q000209:etiology; D009886:Ophthalmoplegia / Q000150:complications / Q000235:genetics*; D006435:Renal Dialysis; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000235:genetics*
chemical_list: D002492:Central Nervous System Depressants; D004272:DNA, Mitochondrial; D000431:Ethanol