[Changes in activity of antioxidant enzymes in the early period after classical and laparoscopic cholecystectomy].
In our study we examined the influence of surgical treatment of gallstones on erythrocyte antioxidant system. The investigated group consisted of thirty three (33) women patients 15 were operated laparoscopically and 18-by means of open cholecystectomy. Using proper criteria of classification to the study we obtained 2 similar groups of patients. We compared changes in activity of antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and level of lipid peroxides (MDA) in early period after operation. The study revealed that laparoscopic cholecystectomy causes minor changes in activity of antioxidant enzymes and level of MDA than open cholecystectomy. Laparoscopic method causes less "oxidative stress" in human erythrocytes which suggests its minor traumatic effect than the open method.
Olakowski
M
M
Kliniki Chirurgii Przewodu Pokarmowego Slaskiej Akademii Medycznej w Katowicach.
Lampe
P
P
Mekle
H
H
Stefański
L
L
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D002763:Cholecystectomy / Q000379:methods*; D017081:Cholecystectomy, Laparoscopic; D002769:Cholelithiasis / Q000201:enzymology / Q000601:surgery*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010088:Oxidoreductases / Q000378:metabolism*; D011184:Postoperative Period; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D010088:Oxidoreductases; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase