Genomic evolution of the distal Mhc class I region on mouse Chr 17.
A 5-Mb YAC contig, partly supplemented with BAC contigs, was created from the distal Mhc class I region on mouse Chr 17. The gene order of Znf173-Tctex5-Mog-D17Tu42-D17Leh 89 is conserved between mouse and human but not the physical distance, supporting the independent expansion of Mhc class I genes in the so-called accordion model of Mhc evolution. The distal H2-M region includes the breakpoint of conserved synteny between mouse and human as well as the In(17)4 t-inversion. The H2-M region is rich in L1 repeats, implying that the insertion of L1 repeats may be associated with the evolutionary flexibility to break a chromosome.
Yoshino
M
M
Howard Hughes Medical Institute, Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas 75235-9050, USA.
Xiao
H
H
Jones
E P
EP
Kumánovics
A
A
Amadou
C
C
Fischer Lindahl
K
K
D000818:Animals; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D019143:Evolution, Molecular; D005805:Genes, MHC Class I; D006801:Humans; D051379:Mice / Q000235:genetics*; D008957:Models, Genetic; D005810:Multigene Family; D013045:Species Specificity