title: Temperature monitoring of ultrasonically heated muscle with RARE chemical shift imaging.
abstract: The ability to monitor tissue temperature in ultrasonically heated rabbit muscle is demonstrated using a chemical shift imaging approach based on the rapid acquisition with relaxation enhancement (RARE) fast imaging method [Hennig et al., Magn. Reson. Med. 3, 823-833 (1986)] applied in a line scan format. A three echo sequence with a 16 Hz spectral resolution with 64 ms echo readouts and 78 ms echo spacings is shown capable of measuring relevantly small water frequency shifts in phantoms. Applied to the in vivo model of ultrasonically heated rabbit muscle, water resonance frequencies at the ultrasonic focal point were found to be linearly related to temperature with a slope of -0.007 +/- 0.001 ppm/degree C (N = 6 studies). Measurements of the frequency shift in unheated tissue located away from the ultrasonically heated tissue varied by approximately 0.011 ppm over the course of the experiments, leading to an estimated temperature accuracy of +/- 1.6 degrees C in vivo.
authors.affiliation: Department of Radiology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. mulkern@bwh.harvard.edu
authors.forename: R V
authors.initials: RV
authors.lastname: Mulkern
authors.forename: A H
authors.initials: AH
authors.lastname: Chung
authors.forename: F A
authors.initials: FA
authors.lastname: Jolesz
authors.forename: K
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D000818:Animals; D001831:Body Temperature; D005782:Gels; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018482:Muscle, Skeletal / Q000502:physiology*; D019047:Phantoms, Imaging; D011817:Rabbits; D012828:Silicones; D014465:Ultrasonics
chemical_list: D005782:Gels; D012828:Silicones