Remote functionalization of the steroid side-chain.
By using classical methods of organic synthesis, the introduction of chemical modifications into the saturated side-chains of steroids usually requires a multistep synthesis to construct new side-chains to be added to the steroid nucleus. In order to circumvent these earlier methods, new procedures have been developed to directly introduce functionality onto the steroid side-chain to produce useful products. These initial products may also provide an entry toward the further modification of the side-chain to produce steroids which could previously be obtained only with great difficulty.
Parish
E J
EJ
Department of Chemistry, Auburn University, Alabama 36849, USA. parisej@mail.auburn.edu
Aksara
N
N
Boos
T L
TL
D006900:Hydroxylation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry*
D013256:Steroids