title: The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development.
abstract: Sine oculis (so) and eyes absent (eya) are required for Drosophila eye development and are founding members of the mammalian Six and Eya gene families. These genes have been proposed to act with eyeless (Pax6) to regulate eye development in vertebrates and invertebrates. so encodes a highly diverged homeobox transcription factor and eya encodes a novel nuclear protein. We demonstrate that So and Eya (1) regulate common steps in eye development including cell proliferation, patterning, and neuronal development; (2) synergize in inducing ectopic eyes; and (3) interact in yeast and in vitro through evolutionarily conserved domains. We propose that an So/Eya complex regulates multiple steps in eye development and functions within the context of a network of genes to specify eye tissue identity.
authors.affiliation: Department of Biological Chemistry, The School of Medicine, University of California, Los Angeles 90095, USA.
authors.forename: F
authors.initials: F
authors.lastname: Pignoni
authors.forename: B
authors.initials: B
authors.lastname: Hu
authors.forename: K H
authors.initials: KH
authors.lastname: Zavitz
authors.forename: J
authors.initials: J
authors.lastname: Xiao
authors.forename: P A
authors.initials: PA
authors.lastname: Garrity
authors.forename: S L
authors.initials: SL
authors.lastname: Zipursky
mesh_terms: D000818:Animals; D019521:Body Patterning; D002455:Cell Division; D004268:DNA-Binding Proteins / Q000502:physiology; D004330:Drosophila; D029721:Drosophila Proteins; D005136:Eye Proteins / Q000502:physiology*; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000502:physiology*; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D017956:Photoreceptor Cells, Invertebrate / Q000196:embryology*; D012097:Repressor Proteins; D014157:Transcription Factors / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; C087345:So protein, Drosophila; D014157:Transcription Factors; C092694:eya protein, Drosophila