[On phenotype and genotype features of serum and erythrocyte proteins in occupation-related bronchopulmonary pathology].
Electrophoresis and isoelectric focusing assessed distribution of phenotypic and gene frequency for 7 highly polymorphic proteins in 163 patients having occupational chronic bronchitis, pneumoconiosis and bronchial asthma. Phenotypic frequency studies, when compared to the reference group, revealed significant differences in the following parameters: proteinase inhibitor, 3rd component of complement, transferrin, serum blood-group specific component, phosphoglucomutase of RBC. Gene frequency studies revealed the significant differences in 3rd component of complement (C3), transferrin (Tf) and phosphoglucomutase of RBC (PGM): the patients demonstrated increased amounts of C3 F, Tf C3 and PGM 2b alleles. The results could be used for individual forecasting the risk of occupational diseases and for choosing the individual prophylactics.
Kuz'mina
L P
LP
Institut meditsiny truda RAMN, Moskva.
D001457:Anion Exchange Protein 1, Erythrocyte / Q000235:genetics* / Q000378:metabolism; D001982:Bronchial Diseases / Q000201:enzymology*; D002908:Chronic Disease; D005838:Genotype; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics* / Q000378:metabolism; D008171:Lung Diseases / Q000201:enzymology; D009784:Occupational Diseases; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics* / Q000378:metabolism; D011480:Protease Inhibitors / Q000097:blood*; D014168:Transferrin / Q000235:genetics*
D001457:Anion Exchange Protein 1, Erythrocyte; D006242:Haptoglobins; D011480:Protease Inhibitors; D014168:Transferrin; D007791:Lactoylglutathione Lyase; D010733:Phosphoglucomutase