[Hypoxyradiotherapy of malignant tumors: experience and perspectives].
The results of the randomized treatment of 1,280 cancer patients (hypooxyradiotherapy (HRT)--923, radiotherapy as a control procedure--357) are discussed. HRT was administered pre-operatively to cases of stomach cancer, colonic carcinoma and breast cancer. Owing to reduced radiation injury caused by HRT, pre-operative dosage was increased by 50% (single dose--6 Gy; total dose--30 Gy; 54 isoGy) in stomach cancer patients, and by 25% (single dose--5; total dose--25 Gy; 40 isoGy) in colonic cancer patients. The time of pre-operative irradiation with a single HRT dose of 10 Gy (28 isoGy) for breast tumors was reduced 4 times. As a result of HRT application, dosage rose by 25-42% in treating pancreatic carcinoma and non-organ retroperitoneal tumors.
Barkanov
A I
AI
Goldobenko
G V
GV
Aralbaev
R T
RT
Liakhova
L A
LA
D005260:Female; D006801:Humans; D000860:Hypoxia; D008297:Male; D009369:Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D011878:Radiotherapy / Q000379:methods; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome