[Molecular-biologic aspects of interaction between nervous and immune systems].
The problem of the neuro-immuno interactions on the level of the protein trans-factors, stimulating interleukin-2 (IL-2) gene expression was discussed. The physico-chemical and functional parameters of the low molecular nuclear proteins (SP and BP- 14, 18, 19 kDs) isolated from splenic and brain cells of immunized rats were studied. The binding of these proteins to the regulatory region of IL-2 gene in vitro and stimulation of the IL-2mRNA synthesis in splenic T-lymphocytes culture in normal conditions were shown. The protective effect of SP and BP on the IL-2mRNA synthesis in stressful conditions and by the T-cells treatment with the CsA was demonstrated.
Korneva
E A
EA
Golovko
O I
OI
Kazakova
T V
TV
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D015213:Neuroimmunomodulation / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D013312:Stress, Physiological / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology
D007376:Interleukin-2; D009687:Nuclear Proteins; D015534:Trans-Activators