Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension.
Cardiac hypertrophy in essential and experimental (genetic) hypertension have been initially attributed to increased pressure load. However, the level of blood pressure does not parallel the degree of cardiac hypertrophy, i.e., a complex relationship rather than a simple dose-response effect has to be suggested. Several non-haemodynamic factors which influence LV mass have been identified with genetic and neuro-hormonal influences playing a major role. The experimental strategies which have been used to highlight one or more of these influences include pharmacological studies of regression or prevention of LVH and studies designed to produce LVH de-novo in normotensive strains. All these studies while confirming an important role of haemodynamic factors also stress the major influence of the renin-angiotensin system and the inter-relationship between angiotensin II and nitric oxide. In contrast, genetic strategies, from simple co-segregation analysis to most complex genome scan studies, suggest the existence of "susceptibility genes" for LV hypertrophy, a finding which deserves further study in large collections of siblings and family groups with essential hypertension.
Dominiczak
A F
AF
Department of Medicine and Therapeutics, Gardiner Institute Western Infirmary, Glasgow.
Devlin
A M
AM
Brosnan
M J
MJ
Anderson
N H
NH
Graham
D
D
Clark
J S
JS
McPhaden
A
A
Hamilton
C A
CA
Reid
J L
JL
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000517:prevention & control; D004198:Disease Susceptibility; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D006984:Hypertrophy; D017379:Hypertrophy, Left Ventricular / Q000235:genetics / Q000503:physiopathology* / Q000517:prevention & control; D019331:NG-Nitroarginine Methyl Ester / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY
D000959:Antihypertensive Agents; D019331:NG-Nitroarginine Methyl Ester