title: Heparan sulphate proteoglycan and wound healing in skin.
abstract: Normal wound healing in skin embraces several reparative processes, many of which directly involve components of the extracellular matrix and the cutaneous basement membrane zone. Proteoglycans are a group of extracellular matrix macromolecules that have both structural and regulatory properties. In wound healing, certain proteoglycans fulfill a mechanical function of absorbing water and preventing tissue compression. However, proteoglycans may also have other roles in wound healing including a direct influence on inflammation, cell attachment and migration, and growth factor binding. Furthermore, proteoglycans may help to determine other aspects of the long-term quality of wound healing in skin through regulation of basement membrane permeability, epidermal hyperproliferation, and dermal fibrosis.
authors.forename: J A
authors.initials: JA
authors.lastname: McGrath
authors.forename: R A
authors.initials: RA
authors.lastname: Eady
mesh_terms: D001485:Basement Membrane / Q000502:physiology; D019812:Heparan Sulfate Proteoglycans / Q000502:physiology*; D006801:Humans; D012867:Skin / Q000293:injuries* / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D019812:Heparan Sulfate Proteoglycans