Diabetic nephropathy with anti-GBM nephritis.
Immune complex glomerulonephritis can be superimposed on diabetic glomerulosclerosis. Idiopathic membranous glomerulonephritis, immunoglobulin (Ig) A glomerulonephritis, Henoch-Schönlein nephritis, membranoproliferative glomerulonephritis, minimal change glomerulonephritis, postinfectious glomerulonephritis, lupus nephritis, amyloidosis, focal segmental glomerulosclerosis, and rarely crescentic glomerulonephritis can all occur with diabetic nephropathy. We describe for the first time an unusual case of diabetic nephropathy coexistent with anti-glomerular basement membrane (GBM) nephritis. The renal function of this patient improved with plasmapheresis and immunosuppressives. We also review the literature on coexistent rapidly progressive glomerulonephritis (RPGN) and diabetic nephropathy.
Ahuja
T S
TS
Department of Medicine, University of Texas Medical Branch at Galveston 77555, USA. tahuja@utmb.edu
Velasco
A
A
Deiss
W
W
Indrikovs
A J
AJ
Rajaraman
S
S
D019867:Anti-Glomerular Basement Membrane Disease / Q000453:epidemiology* / Q000276:immunology / Q000628:therapy; D000906:Antibodies / Q000276:immunology*; D001323:Autoantibodies; D001706:Biopsy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003928:Diabetic Nephropathies / Q000453:epidemiology* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000906:Antibodies; D001323:Autoantibodies; C051951:antiglomerular basement membrane antibody