title: Training effects on soleus of cats spinal cord transected (T12-13) as adults.
abstract: Adult spinal cord transected (T12-13) cats were trained for 30 min/day, 5 days/week to either step on a treadmill (Stp-T) or stand (Std-T) for approximately 5 months. Training ameliorated soleus atrophy and enhanced maximum force capability compared to nontrained (N-T) spinal cats, with Stp-T being significantly different from N-T. Isometric twitch speed and maximum rate of shortening were unaffected by training; the soleus of all spinal groups was significantly faster than control. There was an elevation in myosin adenosine triphosphatase activity and a shift toward faster myosin heavy chain and fiber type compositions in N-T and Std-T, but not Stp-T cats. Thus, rhythmical activity involving muscle length and force changes (stepping) was more effective than a similar amount of a more static activity (standing). This specificity related to the type of training should be considered when developing rehabilitative strategies following spinal cord injury.
authors.affiliation: Brain Research Institute, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, California 90095-1761, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Roy
authors.forename: R J
authors.initials: RJ
authors.lastname: Talmadge
authors.forename: J A
authors.initials: JA
authors.lastname: Hodgson
authors.forename: H
authors.initials: H
authors.lastname: Zhong
authors.forename: K M
authors.initials: KM
authors.lastname: Baldwin
authors.forename: V R
authors.initials: VR
authors.lastname: Edgerton
mesh_terms: D000818:Animals; D001835:Body Weight; D002415:Cats; D002950:Citrate (si)-Synthase / Q000378:metabolism; D007537:Isometric Contraction; D009046:Motor Neurons / Q000502:physiology; D018482:Muscle, Skeletal / Q000166:cytology / Q000294:innervation / Q000502:physiology*; D009210:Myofibrils / Q000502:physiology; D018995:Myosin Heavy Chains / Q000096:biosynthesis; D009218:Myosins / Q000096:biosynthesis; D009929:Organ Size; D010805:Physical Conditioning, Animal; D013116:Spinal Cord / Q000502:physiology*
chemical_list: D002950:Citrate (si)-Synthase; D018995:Myosin Heavy Chains; D009218:Myosins