title: [Efficacy of hepatitis B preventive vaccination].
abstract: Health care workers are at increased hepatitis B risk. In the course of a study with 5035 persons occupied at the Freiburg university hospital, efficacy of hepatitis B vaccination and duration of protection were investigated. Estimations of post-vaccination-anti Hbs showed that women, younger persons, persons with a body mass index < 25 and non-smokers had higher anti Hbs concentrations than men, elderly persons overweight persons and smokers. 2% of female and 1.5% of male vaccinees did not develop anti Hbs and 4.8% and 7.1%, respectively were low responders (anti Hbs < 100 < 10 IU/l). Estimations of vaccination efficacy revealed that even 10 years after basic immunisation at least 50% of all vaccinees should have anti Hbs concentrations > 100 IU/l. The results of the study show that vaccination of children in accordance with German and WHO recommendations will afford full protection (anti Hbs > 10 IU/l) in at least 99% of all cases.
authors.affiliation: Bergische Universität/Gesamthochschule Wuppertal, Lehrstuhl.
authors.forename: F
authors.initials: F
authors.lastname: Hofmann
authors.forename: N
authors.initials: N
authors.lastname: Kralj
authors.forename: H M
authors.initials: HM
authors.lastname: Hasselhorn
authors.forename: M
authors.initials: M
authors.lastname: Nübling
authors.forename: M
authors.initials: M
authors.lastname: Michaelis
authors.forename: H
authors.initials: H
authors.lastname: Berthold
mesh_terms: D000328:Adult; D005260:Female; D005858:Germany; D006509:Hepatitis B / Q000517:prevention & control* / Q000635:transmission; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D017325:Hepatitis B Vaccines