title: Successful treatment of severe refractory idiopathic thrombocytopenic purpura with liposomal doxorubicin.
abstract: Idiopathic thrombocytopenic purpura (ITP) is refractory to initial treatment (steroids and splenectomy) in 25 to 30% of patients. These patients have a significant risk of fatal hemorrhage. Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded to treatment with liposomal doxorubicin with a return of platelet counts to normal. The drug is easily administered and was well tolerated. Use of this drug in refractory ITP merits further study.
authors.affiliation: Hematology-Oncology Services, New Orleans, Louisiana 70006, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Cosgriff
authors.forename: M L
authors.initials: ML
authors.lastname: Black
authors.forename: W
authors.initials: W
authors.lastname: Stein
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008081:Liposomes; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*
chemical_list: D000903:Antibiotics, Antineoplastic; D008081:Liposomes; D004317:Doxorubicin