[Prolactin as an immunomodulator].
The aim of this revision is to explore the possible role of the prolactin in the immune response. The prolactin is a hormone secreted by the pituitary. However, it has a trophic function in the proliferation of the lymphocytes. The cell of the immune system show outer membrane receptor for the prolactin. Moreover, the lymphocytes are capable to produce and secret prolactin. In cell culture, different levels of prolactin show different immune responses- low levels of prolactin awake a weak immune response. In contrast, high levels of prolactin show a strong immune response. Alteration in the sera levels of prolactin has been describes in severe autoimmune disease like systemic lupus erythematosus. Reiter syndrome, adjuvant arthritis, uveitis etc. Until now many evidences has been reported about the roles of the prolactin in the immune response acting like an immunomodulator, but the relevance of this phenomena in the clinical practice is still unclear.
Leaños Miranda
A
A
Laboratorio de Autoinmunidad, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS.
Quintal Alvarez
M G
MG
Cervera Castillo
H
H
Blanco Favela
F
F
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D015415:Biomarkers; D001971:Bromocriptine / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000503:physiopathology; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy / Q000276:immunology; D007109:Immunity / Q000502:physiology*; D007378:Interleukins / Q000502:physiology; D008213:Lymphocyte Activation / Q000502:physiology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D011388:Prolactin / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D011981:Receptors, Prolactin / Q000502:physiology
D015415:Biomarkers; D007378:Interleukins; D011981:Receptors, Prolactin; D001971:Bromocriptine; D011388:Prolactin