The consequence of translesional replication of unique UV-induced photoproducts.
The consequence of translesional replication of unique UV-induced photoproducts is reviewed here. Mutagenesis induced by unique UV-induced lesions, the thymine-thymine dimer (TT) and the thymine-thymine pyrimidine pyrimidone (6-4), [T(6-4)T] carried on single-stranded DNA vectors and replicated in bacteria, yeast and mammalian cells have been considered. It has been found that in all of the three species the (TT) dimers induce a low mutation frequency compared to the (6-4) photoproduct. The molecular analysis of the mutations induced is reported, showing specific differences depending on the species considered.
Gentil
A
A
Laboratory of Molecular Genetics, Institut de Recherches sur le Cancer - IFC1 - C.N.R.S., Villejuif, France.
Le Page
F
F
Sarasin
A
A
D000818:Animals; D001419:Bacteria / Q000235:genetics; D004247:DNA / Q000528:radiation effects*; D018736:DNA Adducts; D004249:DNA Damage; D004261:DNA Replication / Q000528:radiation effects*; D004277:DNA, Single-Stranded; D019281:Dimerization; D006801:Humans; D008322:Mammals / Q000235:genetics; D009154:Mutation; D013941:Thymine; D014466:Ultraviolet Rays; D015003:Yeasts / Q000235:genetics
D018736:DNA Adducts; D004277:DNA, Single-Stranded; D004247:DNA; D013941:Thymine