Treatment of convulsive status epilepticus with propofol: case report.
BACKGROUND
Convulsive status epilepticus (CSE) refractory to treatment with benzodiazepines, phenobarbital, and phenytoin presents a challenge to pediatric emergency and critical care specialists. Prompt seizure control may prevent mortality and morbidity.


METHODS
A nine-month-old girl with hereditary fructose intolerance had prolonged, refractory CSE. Her seizures promptly stopped after administration of propofol (3 mg/kg bolus followed by infusion of 100 micrograms/kg/min). This dose resulted in electroencephalographic burst suppression. She required endotracheal intubation, invasive hemodynamic monitoring, and pressor support.


CONCLUSIONS
This is the first pediatric case of prolonged, refractory CSE treated with propofol. The adult experience is reviewed. Propofol should be used only in a setting where definitive airway control and hemodynamic support is possible.
Harrison
A M
AM
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA.
Lugo
R A
RA
Schunk
J E
JE
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D015742:Propofol / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy*; D013226:Status Epilepticus / Q000188:drug therapy*
D000927:Anticonvulsants; D015742:Propofol