title: [Calculation of the dose of sodium bicarbonate in the treatment of metabolic acidosis in surgery with and deep hypothermic circulatory arrest].
abstract: The study was aimed at detection of the factors which determine the amount of 7% sodium hydrocarbonate (SHC) needed to correct metabolic acidosis in patients subjected to repair surgery on the aorta involving long arrest of circulation under conditions of deep hypothermia. The total dose of 7% SHC solution was calculated as the sum of volumes of this solution needed to neutralize the tissue non-oxidized metabolites and BE. Accumulation of acid metabolites in tissues is caused by ineffective compensation of energy expenditure of the organism during warming of a patient after circulatory arrest and deep hypothermia. After reperfusion injury to tissues the release of these metabolites into the blood and further neutralization are appreciably slower during such operations than during other cardiovascular bypass interventions. That is why the routine method for calculating the dose of 7% SHC solution for correcting metabolic acidosis is not adequate in cases with abnormal body temperature. Estimation of the dose with consideration for venous blood temperature and pO2 is more correct. An algorithm of calculation is proposed.
authors.forename: I I
authors.initials: II
authors.lastname: Dement'eva
authors.forename: E V
authors.initials: EV
authors.lastname: Roĭtman
authors.forename: E N
authors.initials: EN
authors.lastname: Maĭba
authors.forename: M A
authors.initials: MA
authors.lastname: Charnaia
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Zolicheva
authors.forename: I V
authors.initials: IV
authors.lastname: Bogorad
mesh_terms: D000138:Acidosis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D001014:Aortic Aneurysm / Q000601:surgery*; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery; D001831:Body Temperature; D004734:Energy Metabolism; D006324:Heart Arrest, Induced; D006801:Humans; D007036:Hypothermia, Induced; D008962:Models, Theoretical; D010100:Oxygen / Q000097:blood; D017693:Sodium Bicarbonate / Q000008:administration & dosage*
chemical_list: D017693:Sodium Bicarbonate; D010100:Oxygen