Biology of HIV-1 in women and men.
The 1990s have been marked by tremendous progress in understanding HIV-1 infection and disease progression in infected individuals. The new discoveries have direct applications in predicting clinical outcomes and monitoring antiviral therapies. With the identification of secondary receptors for HIV-1 cell entry, the CCR-5 receptor was found to be a single genetically determined factor influencing both HIV-1 transmission and disease progression. Quantitation of HIV-1 RNA led to the discoveries that detectable or even high levels of HIV-1 replication occur during all phases of infection, and that plasma HIV-1 RNA levels are powerful predictors of clinical outcome. These findings have increased the ability to predict disease progression and to monitor-antiviral therapy in infected individuals.
Burger
H
H
New York State Department of Health, Albany, USA.
Weiser
B
B
D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission / Q000821:virology*; D005260:Female; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D012367:RNA, Viral; D019707:Receptors, Chemokine / Q000378:metabolism; D012737:Sex Factors; D019562:Viral Load
D012367:RNA, Viral; D019707:Receptors, Chemokine