title: [Immune resistance of humans during extended isolation].
abstract: Analyzed were parameters of the immune reactivity and allergological status of participants in the 135-day chamber experiment with periods of induced psychoemotional strain. Stressful situations gave rise to shifts in the antibody system, i.e. decreased blood levels of ImgA, ImgM, and ImgG, decline in the functional activity of T-lymphocytes, suppression of the cytokinetic activity of lymphocytes-natural killers, and sensibilization to various allergens. Totality of these shifts resembles the ones which are typically seen during initial readaptation to the Earth's conditions on after long-term space mission.
authors.affiliation: Gosudarstvennyĭ nauchnyĭ tsentr RF "Institut mediko-biologicheskikh problem".
authors.forename: I V
authors.initials: IV
authors.lastname: Konstantinova
authors.forename: E N
authors.initials: EN
authors.lastname: Antropova
authors.forename: D O
authors.initials: DO
authors.lastname: Meshkov
authors.forename: M P
authors.initials: MP
authors.lastname: Rykova
authors.forename: A T
authors.initials: AT
authors.lastname: Lesniak
mesh_terms: D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008214:Lymphocytes / Q000502:physiology; D013026:Space Flight; D013997:Time Factors
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M