title: Clonazepam: benzodiazepine therapy for the restless legs syndrome.
abstract: Clonazepam is one of several agents used for the treatment of the restless legs syndrome of ESRD. The drug's pharmacokinetic profile demonstrates safety in patients with altered kidney function. Future studies may provide an enhanced understanding of the physiological basis of the disorder to lead to improved pharmacological therapy. Other medication alternatives such as narcotics, dopamine agonists, clonidine, and gabepentin are available for patients unable to tolerate or receive benefit from clonazepam.
authors.affiliation: University of North Carolina, School of Medicine, Division of Nephrology and Hypertension, Chapel Hill, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Joy
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use*; D018757:GABA Modulators / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000209:etiology
chemical_list: D014151:Anti-Anxiety Agents; D018757:GABA Modulators; D002998:Clonazepam