title: Primary lymphoma of the internal auditory canal. Case report and review of the literature.
abstract: We report a rare case of a primary intracranial B cell lymphoma originating in the internal auditory canal. The clinical manifestations were indistinguishable from those of other, more common tumors of the same region. We achieved total gross tumor removal with preservation of the facial nerve. A detailed histologic examination and a systemic workup confirmed the primary nature of this tumor. To our knowledge, this is the second case reported in the literature of a primary malignant lymphoma originating in the internal auditory canal. This is the first instance that includes immunohistochemical and cytometric studies of fresh tissue. We discuss the management of primary lymphomas of the central nervous system, with special emphasis on their association with acquired immunodeficiency syndrome and other immune system diseases. Awareness of primary central nervous system lymphomas is important, since a greater occurrence of these rare tumors in the cerebellopontine angle is probable in the future.
authors.affiliation: House Ear Clinic, Los Angeles, CA 90057, USA.
authors.forename: S I
authors.initials: SI
authors.lastname: Angeli
authors.forename: D E
authors.initials: DE
authors.lastname: Brackmann
authors.forename: J E
authors.initials: JE
authors.lastname: Xenellis
authors.forename: B J
authors.initials: BJ
authors.lastname: Poletti
authors.forename: J N
authors.initials: JN
authors.lastname: Carberry
authors.forename: W E
authors.initials: WE
authors.lastname: Hitselberger
mesh_terms: D004424:Ear Canal / Q000473:pathology* / Q000601:surgery; D004428:Ear Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D005434:Flow Cytometry; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology* / Q000601:surgery; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged