title: Age dependent changes in serotonin and dopamine receptors in Aplysia californica.
abstract: Age related changes in dopaminergic and serotonergic receptors were examined in Aplysia californica. In this study dopamine (DA) and serotonin (5-HT) receptor levels were examined for animals belonging to 4-, 5-, 6-, 8-, 9- and 12-month age groups. Receptors analysis was performed using radio-labeled d-[3H] lysergic acid diethylamide (LSD) as the specific ligand. Specific binding for 5-HT was found to be significantly greater than that for DA in the young (4-month post-hatch) animals. The total DA and 5-HT receptor levels changed significantly with age. Dopamine levels increased from 5.34 fmol/mg of protein at 4 months to 19.11 fmol/mg at 12 months. Serotonin receptor levels increased from 7.35 fmol/mg at 4 months to 20.45 at 12 months.
authors.affiliation: Department of Biology, George Mason University, Fairfax, VA 22030-4444, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Southall
authors.forename: J M
authors.initials: JM
authors.lastname: Flinn
authors.forename: R W
authors.initials: RW
authors.lastname: Holt
authors.forename: V
authors.initials: V
authors.lastname: Chandhoke
mesh_terms: D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001048:Aplysia / Q000254:growth & development*; D017952:Ganglia, Invertebrate / Q000378:metabolism; D008238:Lysergic Acid Diethylamide / Q000378:metabolism; D011869:Radioligand Assay; D011954:Receptors, Dopamine / Q000378:metabolism / Q000502:physiology*; D011985:Receptors, Serotonin / Q000378:metabolism / Q000502:physiology*
chemical_list: D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D008238:Lysergic Acid Diethylamide