Experimental studies on acute and chronic action of azelastine on nasal mucosa in guinea pigs, rats and dogs.
Azelastine (CAS 37932-96-0) nasal spray (Allergodil, Rhinolast, Astelin) was investigated in acute experiments in guinea pigs and after a 26-week local application period with daily repeated administration for effects on ciliary beat activity (acute experiments) and morphology of nasal mucosa. The commercially available spray did not inhibit ciliary beat activity in guinea pigs nor did it cause any inflammatory or atrophic changes after 26-week daily local application on nasal mucosa in rats and dogs.
Achterrath-Tuckermann
U
U
Biologische Forschung, ASTA Medica AG, Frankfurt/Main, Germany.
Berthold
K
K
Roux
J
J
Procter
B G
BG
McDonald
P
P
Szelenyi
I
I
Sofia
R D
RD
Herbst
M
M
D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects*; D010793:Phthalazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D018926:Anti-Allergic Agents; D010793:Phthalazines; C020976:azelastine