title: Innovations and advances in brachytherapy.
abstract: The treatment of cancer with radioactive sources using topical molds and intracavitary radium showed the efficacy of brachytherapy long before external radiation therapy became common practice. Brachytherapy is progressing in several clinical directions that reflect technological innovation as well as changes in medical care which combine to provide significant advances in the practice of brachytherapy today. A major change in brachytherapy, the development of high intensity sources, promoted clinical and technologic innovations in high dose-rate brachytherapy. Pulse dose-rate brachytherapy is the use of these sources to treat a target by using pulses of radiation for several minutes each hour with the same overall time and total dose as low dose-rate treatment. Recent novel approaches of using radiotherapy for prevention of restenosis in coronary and peripheral vessels has interested laboratory and clinical researchers. Most of the work toward new source material for brachytherapy centers around intravascular applications. Technology to support brachytherapy continues to advance rapidly. The interaction between images from diverse modalities and the various phases of the treatment planning is the basis of enhanced treatment planning procedures. Optimization in brachytherapy entails calculating the source strengths or source dwell times to satisfy a set of dose criteria to achieve the best dose distribution for a brachytherapy implant. Progress in computerization and calculation modeling has promoted this technical advance. Education and training in brachytherapy indications and techniques is mandatory to maintain high standards of brachytherapy practice.
authors.affiliation: University of Wisconsin Comprehensive Cancer Center, Madison 53792, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Stitt
authors.forename: B R
authors.initials: BR
authors.lastname: Thomadsen
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000379:methods / Q000639:trends; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D019300:Medical Errors; D009369:Neoplasms / Q000532:radiotherapy*; D015642:Radiology, Interventional; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted