title: Decay of Ca2+ and force transients in fast- and slow-twitch skeletal muscles from the rat, mouse and Etruscan shrew.
abstract: Isometric single-twitch force and intracellular Ca2+ transients were recorded simultaneously, using fura-2, from slow- and fast-twitch muscle fibres of the rat, mouse and Etruscan shrew Suncus etruscus. In the slow-twitch rat soleus, force half-relaxation time was three times longer than the 50 % decay time of the fura-2 signal. In contrast, in the fast-twitch extensor digitorum longus muscles of all three animals, muscle relaxation preceded Ca2+ decay. It is proposed that this surprising property of fast-twitch muscles is due to their pCa&shy;tension curve, which is shifted to the right compared with that of slow-twitch muscle.
authors.initials: P
authors.lastname: Wetzel
authors.lastname: g