Ventricular functions in children with human immunodeficiency virus infection after ACE-inhibitors.
Nine pediatric symptomatic patients infected with human immunodeficiency virus with elevated pulmonary arterial pressure (MPA pressure) and ejection fraction (EF); and with fractional shortening, (FS) mean velocity of circumferential fiber shortening (MVCfc) and left ventricular peak systolic wall stress (PS) were prospectively evaluated using 2-dimensional and M-mode serial echocardiography and Doppler cardiography after administration of an ACE inhibitor (Inhibace 0.025 mg/kg/D orally) for 12 weeks. The MPA pressure was not decreased, however the MVCfc and PS improved significantly (p < 0.05). Further, long term evaluation is required to determine its effect in preventing dilated cardiomyopathy and elevated mean pulmonary pressure.
Anuroj
K
K
Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Pathmanand
C
C
Sueblinvong
V
V
Thisyakorn
C
C
Chotivitayatarakorn
P
P
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000517:prevention & control* / Q000821:virology; D002675:Child, Preschool; D017315:Cilazapril / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000821:virology; D007223:Infant; D008297:Male; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D014463:Ultrasonography; D018754:Ventricular Dysfunction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000821:virology
D000806:Angiotensin-Converting Enzyme Inhibitors; D017315:Cilazapril