Primary Sjögren's syndrome associated with hyaline-vascular type of Castleman's disease and autoimmune idiopathic thrombocytopenia.
We describe a case of primary Sjögren's syndrome complicated by hyaline-vascular type of Castleman's disease and autoimmune idiopathic thrombocytopenia. This type of Castleman's disease was diagnosed by biopsy of a right axillary lymph node 7 years after the onset of Sjögren's syndrome. The specimen showed small hyaline-vascular lymphoid follicles and interfollicular capillary proliferation. Serum IL-6 was slightly increased, but systemic manifestations, such as fever or weight loss, were not present. Hyaline-vascular type of Castleman's disease should be considered a lymphoproliferative disorder associated with Sjögren's syndrome.
Higashi
K
K
National Defense Medical College, Japan.
Matsuki
Y
Y
Hidaka
T
T
Aida
S
S
Suzuki
K
K
Nakamura
H
H
D001706:Biopsy; D005871:Castleman Disease / Q000150:complications*; D005260:Female; D006801:Humans; D006818:Hyalin; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D012859:Sjogren's Syndrome / Q000150:complications*