Measurement of hemodynamics of auditory cortex using magnetoencephalography and near infrared spectroscopy.
Near infrared (NIR) spectroscopy, a non-invasive optical method for monitoring hemodynamics, was applied to record evoked auditory response of the human brain. Our newly developed system detected the amount of oxygenated and deoxygenated hemoglobin in the area of the local brain located beneath the probes. In the study, we used magnetoencephalography (MEG) and NIR spectroscopy to observe the blood component change near the auditory cortex. The sound stimulus of 1 kHz sine wave at 70 dB SPL was used to elicit evoked responses in both experiments. The active region of the auditory cortex was determined by MEG, and the same area was examined by the NIR system. The results from the NIR experiments showed significant increases of total hemoglobin and deoxygenated hemoglobin, indicating that both blood flow and oxygen consumption at the cortical area increased in response to the sound stimuli. The NIR recordings at the two different depths revealed that the increases of local blood flow and oxygen consumption were observed at depths ranging between 20 and 30 mm from the scalp.
Ohnishi
M
M
ATR Human Information Processing Research Laboratories, Kyoto, Japan. moonishi@devd.crl.sony.co.jp
Kusakawa
N
N
Masaki
S
S
Honda
K
K
Hayashi
N
N
Shimada
Y
Y
Fujimoto
I
I
Hirao
K
K
D000328:Adult; D001303:Auditory Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005072:Evoked Potentials, Auditory; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D010101:Oxygen Consumption; D019265:Spectroscopy, Near-Infrared