Immunization of Aotus monkeys with recombinant Plasmodium falciparum hybrid proteins does not reproducibly result in protection from malaria infection.
Plasmodium falciparum antigens SERP, HRPII, MSAI, and 41-3 have shown promise as vaccine components. This study aimed at reproducing and extending previous results using three hybrid molecules. Antibody responses were reproduced in Aotus monkeys, but solid protection from a P. falciparum blood-stage challenge that showed an unintendedly enhanced pathogenicity was not observed.
Kocken
C H
CH
Biomedical Primate Research Centre, Department of Parasitology, Rijswijk, The Netherlands. kocken@bprc.nl
Hundt
E
E
Knapp
B
B
Brazel
D
D
Enders
B
B
Narum
D L
DL
Wubben
J A
JA
Thomas
A W
AW
D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis* / Q000276:immunology; D000953:Antigens, Protozoan / Q000235:genetics / Q000276:immunology; D016645:Aotidae; D016778:Malaria, Falciparum / Q000276:immunology* / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D016052:Protozoan Vaccines; D011994:Recombinant Proteins / Q000276:immunology*; D014611:Vaccination
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D011994:Recombinant Proteins; C057495:serine repeat antigen, Plasmodium