Treatment of recurrent conjunctival epithelial neoplasia with topical mitomycin C.
OBJECTIVE
To study the effect of topical mitomycin C on conjunctival squamous neoplasia.


METHODS
Three patients with recurrent conjunctival epithelial neoplasia were treated with topical mitomycin C 0.04%.


RESULTS
Six to 9 months after treatment, no patient had clinical evidence of tumor recurrence. Conjunctival biopsy in two patients and cytology in one patient showed no evidence of tumor 1 to 4 months after treatment. One patient required short-term treatment for corneal edema and epithelial toxicity.


CONCLUSIONS
Topical mitomycin C caused tumor regression without recurrence for 6 to 9 months after treatment.
Heigle
T J
TJ
Bascom Palmer Eye Institute, Emory University, Atlanta, GA 30322, USA.
Stulting
R D
RD
Palay
D A
DA
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009883:Ophthalmic Solutions; D012008:Recurrence; D012074:Remission Induction
D000903:Antibiotics, Antineoplastic; D009883:Ophthalmic Solutions; D016685:Mitomycin