Presession noise increases sensitivity to chlordiazepoxide's discriminative stimulus in pigeons.
1. Pigeons were trained to discriminate chlordiazepoxide (CDP) from saline using two-key food reinforced drug discrimination procedures. Discriminative control by CDP was maintained despite extended training with vehicle-like doses of CDP, by using a modified "fading" procedure that provided for a mixture of drug discrimination training sessions preceded by an i.m. injection of either 8.0 mg/kg CDP, or a lower training dose of CDP (4.0, 2.8, 2.0, 1.4, 1.0, 0.7, or 0.5 mg/kg CDP), or saline. The lower training dose was decreased across blocks of sessions. 2. Four lower training doses (1.4, 1.0, 0.7, and 0.5 mg/kg CDP) were retrained, with 10 min of 98 dB of noise administered 75 min prior to each drug discrimination training session. Presession exposure to noise increased percent CDP-appropriate choices for each of the four lower training doses by 15-20% over those obtained previously. 3. It is concluded that brief presession exposure to loud noise increases sensitivity to the discriminative stimulus effects of low training doses of CDP.
Tomie
A
A
Department of Psychology, Rutgers University, New Brunswick, NJ, USA.
Shultz
P L
PL
Quartarolo
N M
NM
Cunha
C
C
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000008:administration & dosage / Q000494:pharmacology*; D010856:Columbidae; D004193:Discrimination Learning; D009622:Noise; D012055:Reinforcement Schedule; D013315:Stress, Psychological
D014151:Anti-Anxiety Agents; D002707:Chlordiazepoxide