title: Obliterative central bronchitis due to mineral dust in patients with pneumoconiosis.
abstract: OBJECTIVE
  We studied at autopsy a distinctive obliterative bronchitis in three persons with pneumoconiosis and hilar node fibrosis.
  
  
  METHODS
  Lungs were evaluated macroscopically, microscopically, and with energy-dispersive spectroscopy.
  
  
  RESULTS
  Chest roentgenogram demonstrated right middle lobe syndrome in one patient; bronchostenosis was seen at bronchoscopy in another. The stenotic sites were in perihilar bronchi and showed an upper lobe predominance. Fibrosis with silicotic nodules involved the bronchus, peribronchial tissue, and adjacent lymph nodes. Simple coalworkers' pneumoconiosis was observed in two patients; the third had complicated, mixed dust fibrosis.
  
  
  CONCLUSIONS
  Obliterative bronchitis represents an unusual fibrotic response to free crystalline silica. The process may occur simultaneously in the adjacent lymph node and the bronchial wall; however, it need not be associated with complicated pneumoconiosis. Clinically, obliterative bronchitis may masquerade as bronchogenic carcinoma.
authors.affiliation: Department of Pathology, Case Western Reserve University, School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109-1998, USA.
authors.forename: B N
authors.initials: BN
authors.lastname: Kampalath
authors.forename: J T
authors.initials: JT
authors.lastname: McMahon
authors.forename: A
authors.initials: A
authors.lastname: Cohen
authors.forename: J F
authors.initials: JF
authors.lastname: Tomashefski
authors.forename: J
authors.initials: J
authors.lastname: Kleinerman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001980:Bronchi / Q000473:pathology; D001991:Bronchitis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D004391:Dust / Q000009:adverse effects*; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D019016:Mineral Fibers / Q000009:adverse effects*; D011009:Pneumoconiosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D013902:Radiography, Thoracic; D012822:Silicon Dioxide / Q000009:adverse effects / Q000032:analysis; D013057:Spectrum Analysis; D014057:Tomography, X-Ray Computed
chemical_list: D004391:Dust; D019016:Mineral Fibers; D012822:Silicon Dioxide