Fetal calf serum decreases CYP3A induction in rat but not in dog or human hepatocyte cultures.
Jackson
F C
FC
Department of Medicine, University of Aberdeen, UK.
Chenery
R J
RJ
Hawksworth
G M
GM
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D001769:Blood; D002417:Cattle; D002478:Cells, Cultured; D003470:Culture Media; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D003907:Dexamethasone / Q000494:pharmacology; D004285:Dogs; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005333:Fetus; D006801:Humans; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D010089:Oxidoreductases, N-Demethylating / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012293:Rifampin / Q000494:pharmacology
D003470:Culture Media; D003907:Dexamethasone; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating; D012293:Rifampin