title: d-Amphetamine attenuates decreased cerebral glucose utilization after unilateral sensorimotor cortex contusion in rats.
abstract: Unilateral contusion injury to the sensorimotor cortex causes, among other symptoms, a transient contralateral hindlimb hemiparesis in rats. A single i.p. 2 mg/kg dose of d-amphetamine (d-AMPH) 24 h after injury accelerates spontaneous recovery from this particular deficit. The mechanism(s) of spontaneous and d-AMPH enhanced recovery are unknown but alleviation of a neuronal depression has been proposed. This quantitative CMRglu study was designed to determine effects of cortical contusion injury and d-AMPH on CMRglu in cortical and subcortical structures. At 2 days after injury, CMRglu was significantly reduced compared to sham-operated controls only in structures ipsilateral to contusion. Affected structures included the caudate putamen, medial geniculate nucleus, lateral geniculate nucleus and the parietal cortex immediately posterior to injury. By 6 days post-contusion, the hypometabolism partially reversed in all structures. A single low dose of d-AMPH significantly alleviated the post-traumatic CMRglu reduction at 2 days after injury. Importantly, while this alleviation was not significant for any single structure, the main effect of treatment was highly significant. d-AMPH increased CMRglu at 2 days post-injury by 18-33% compared to contused/saline-treated rats. These results suggest that alleviation of neuronal metabolic depression may contribute to spontaneous and d-AMPH enhanced recovery.
authors.affiliation: Physical Therapy Department, School of Pharmacy and Allied Health Sciences, The University of Montana, Missoula 59812-1076, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Queen
authors.forename: M J
authors.initials: MJ
authors.lastname: Chen
authors.forename: D M
authors.initials: DM
authors.lastname: Feeney
mesh_terms: D000818:Animals; D001924:Brain Concussion / Q000188:drug therapy* / Q000378:metabolism; D001933:Brain Stem / Q000293:injuries; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003342:Corpus Striatum / Q000293:injuries; D003913:Dextroamphetamine / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D010296:Parietal Lobe / Q000187:drug effects / Q000293:injuries / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000187:drug effects / Q000293:injuries* / Q000378:metabolism
chemical_list: D000697:Central Nervous System Stimulants; D005947:Glucose; D003913:Dextroamphetamine