title: Planar polarization of Drosophila and vertebrate epithelia.
abstract: Our understanding of the actin and microtubule rearrangements that generate planar polarity in Drosophila and in vertebrate epithelia has been extended by recent discoveries. Three different Rho family proteins have been shown to mediate polarization in the wing and the eye of Drosophila. In vertebrates, the importance of myosin VIIa has been uncovered by mutations that cause defects in planar polarization in the ear. Advances in our understanding of the Frizzled pathway, which coordinates planar polarization in Drosophila, are moving the field closer to understanding the links between signal transduction and polarized cytoskeletal reorganization.
authors.affiliation: Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany. eaton@embl-heidelberg.de
authors.forename: S
authors.initials: S
authors.lastname: Eaton
mesh_terms: D000818:Animals; D019521:Body Patterning; D002450:Cell Communication; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D004330:Drosophila / Q000033:anatomy & histology* / Q000254:growth & development* / Q000502:physiology; D029721:Drosophila Proteins; D004398:Dyneins; D004848:Epithelium / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology; D051157:Frizzled Receptors; D019204:GTP-Binding Proteins / Q000502:physiology; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D000081412:Myosin VIIa; D009218:Myosins / Q000502:physiology; D043562:Receptors, G-Protein-Coupled; D015398:Signal Transduction; D014714:Vertebrates / Q000033:anatomy & histology* / Q000254:growth & development* / Q000502:physiology
chemical_list: D029721:Drosophila Proteins; D051157:Frizzled Receptors; D019476:Insect Proteins; D008565:Membrane Proteins; D000081412:Myosin VIIa; D043562:Receptors, G-Protein-Coupled; C058784:fz protein, Drosophila; C000631458:myosin 7a, Drosophila; D019204:GTP-Binding Proteins; D009218:Myosins; D004398:Dyneins