Production of brominated tiacumicin derivatives
Several novel tiacumicin derivatives containing bromine have been produced by the addition of inorganic bromine to the fermentation broth of Dactylosporangium aurantiacum subsp. hamdenesis. Structures were elucidated employing mass spectrometry and NMR spectroscopy. Antibacterial activity of the bromotiacumicins is comparable to that of the parent compounds.
Hochlowski
JE
Pharmaceutical Products Research and Development Abbott Laboratories, Abbott Park, Illinois 60064, USA.
Jackson
M
Rasmussen
RR
Buko
AM
Clement
JJ
Whittern
DN
McAlpine
JB