A comprehensive analysis of complex traits in problem 2A.
We used descriptive analysis to investigate the relationship between affection status and five quantitative traits (Q1-Q5) in Problem 2A and results suggested the five quantitative traits fall into two groups. The first group comprised three strongly correlated traits, Q1-Q3, which underlie affection status, and the second group comprised Q4 and Q5, which are not directly related to affection status. Segregation and linkage analyses of traits Q1-Q3 and affection status from the first replicate detected one of the major loci for Q1 (MG1) linked to marker 14 on chromosome 5 (D5G14). Because our segregation analysis failed to show evidence of a major locus effect on Q2, and we overlooked the interaction between MG3 and sex, we did not detect either MG2 or MG3. Using Haseman-Elston sib-pair analysis [Haseman and Elston, 1972], we also examined the statistical power of Q1 and type I error rate (using the environmental factor as an index), for the remaining 199 replicates in the context of a genome screen.
Juo
S H
SH
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Beaty
T H
TH
Duffy
D L
DL
Maestri
N E
NE
Prenger
V L
VL
Zeiger
J
J
Lei
H H
HH
Coresh
J
J
D002874:Chromosome Mapping; D004777:Environment; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D016014:Linear Models; D008126:Lod Score; D008297:Male; D016555:Matched-Pair Analysis; D015233:Models, Statistical; D009679:Nuclear Family; D011237:Predictive Value of Tests; D019655:Quantitative Trait, Heritable
D005819:Genetic Markers