title: Isotypic antibody responses of a population in an endemic area of schistosomiasis japonica and their epidemiologic significance.
abstract: The present study was designed to explore if there exists a correlation between predominant isotype-defined antibody levels and reinfection in low age groups of the population in an endemic area of schistosomiasis japonica in China. One hundred and thirty-eight individuals aged 3-25 years old were selected for serological investigations including the levels of IgG, IgG4, IgM and IgE, detected by ELISA with soluble egg antigen and soluble adult worm antigen. Results show that age is a determinant for SEA-specific IgG, IgG4, and IgE, and SWA-specific IgG and IgG4 antibody levels, which increased with age, and that SEA- and SWA- specific IgG4 antibody levels are risk factors of reinfection, ie, the risk of reinfection occurrence of the population with high level of SEA or SWA-specific IgG4 is 2.83 or 2.40 times, respectively, that with low level of SEA or SWA-specific IgG4, suggesting that in the endemic area of schistosomiasis japonica, there exists a possibility that in the population aged 3-25 years, SEA and SWA-specific IgG4 antibodies mediate a blocking immunity response.
authors.affiliation: Molecular and Immunoparasitology Research Department, Nanjing Medical University, Jiangsu, People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Hu
authors.forename: Z
authors.initials: Z
authors.lastname: Xie
authors.forename: Y
authors.initials: Y
authors.lastname: Qiu
authors.forename: C
authors.initials: C
authors.lastname: Su
authors.forename: J
authors.initials: J
authors.lastname: Cao
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000909:Antibodies, Helminth / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000097:blood*; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012554:Schistosomiasis japonica / Q000453:epidemiology / Q000276:immunology*; D017678:Sex Distribution
chemical_list: D000909:Antibodies, Helminth; D007132:Immunoglobulin Isotypes