Insulin injection sites: morphology and immunohistochemistry.
In a case of insulin suicide in a nondiabetic woman, insulin was detected in routinely formalin fixed and paraffin embedded subcutaneous injection marks, in spite of a post-morterm interval of 24 days. Around birefringent crystalline material, probably zinc phosphate, immunohistochemistry revealed granular insulin depots as well as an insulin staining along the lipocyte membranes. A cellular reaction of granulocytic character was present, with an uptake of insulin by inflammatory cells.
Lutz
R
R
Institute of Forensic Medicine, University of Heidelberg, Germany.
Pedal
I
I
Wetzel
C
C
Mattern
R
R
D001344:Autopsy / Q000379:methods*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000506:poisoning*; D007150:Immunohistochemistry; D007279:Injections, Subcutaneous; D007328:Insulin / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D011180:Postmortem Changes; D012867:Skin / Q000473:pathology*; D013405:Suicide; D013997:Time Factors
D007004:Hypoglycemic Agents; D007328:Insulin