Effects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats.
The therapeutic effects of nimodipine (CAS 66085-59-4) and ofloxacin (CAS 82419-36-1) were investigated against experimental brain abscess formation in rats. Nimodipine, a 1,4-dihydropyridine derivative, is chemically related to nifedipine but the smooth muscle relaxant effect preferentially acts on cerebral arteries. Ofloxacin is a member of 4-Quinolone broad spectrum antibiotics. Ninety-six male Sprague-Dawley rats were inoculated intracortically with Staphylococcus aureus and then different groups were treated with either saline, ofloxacin or the combination of ofloxacin and nimodipine. The rate of brain abscess formation and mortality were considerably decreased by nimodipine and ofloxacin therapy. Combination therapy was found histologically to be considerably more effective than ofloxacin alone against brain abscess formation in rats.
Ceviz
A
A
Department Neurosurgery, Medicinal Faculty, Dicle University, Diyarbakir, Turkey.
Inalöz
S S
SS
Ciçek
R
R
Sari
I
I
Gül
K
K
Sanli
A
A
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001922:Brain Abscess / Q000188:drug therapy* / Q000382:microbiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D008297:Male; D009553:Nimodipine / Q000627:therapeutic use*; D015242:Ofloxacin / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology
D000890:Anti-Infective Agents; D002121:Calcium Channel Blockers; D009553:Nimodipine; D015242:Ofloxacin