The cyclin box fold: protein recognition in cell-cycle and transcription control.
Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.
Noble
M E
ME
Oxford Centre for Molecular Sciences, UK.
Endicott
J A
JA
Brown
N R
NR
Johnson
L N
LN
D000595:Amino Acid Sequence; D002453:Cell Cycle; D019925:Cyclin A / Q000737:chemistry* / Q000378:metabolism; D056748:Cyclin H; D016213:Cyclins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016160:Retinoblastoma Protein / Q000737:chemistry* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D035581:Transcription Factor TFIIB; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism; D014158:Transcription, Genetic
D019925:Cyclin A; D056748:Cyclin H; D016213:Cyclins; D016160:Retinoblastoma Protein; D035581:Transcription Factor TFIIB; D014157:Transcription Factors