Variations of teicoplanin concentrations in neutropenic patients.
The aim of this study was to measure the trough plasma concentrations of teicoplanin in neutropenic patients with a view to optimizing the loading dose. Teicoplanin trough plasma concentrations were followed in 11 neutropenic patients after repeated administration of a 6 mg/kg i.v. bolus. The first three injections were given at 12-h intervals, and the rest every 24 h. Trough plasma concentrations at 48 h varied from 5.6 to 13.1 mg/I. The mean trough plasma concentration-time curve indicated a trend towards accumulation. In conclusion, the loading dose of teicoplanin should be tailored to individual neutropenic patients.
Gimenez
F
F
Service de Pharmacie-Pharmacocinétique, Hôpital Pitié Salpêtrière, Paris, France.
Leblond
V
V
Nguyen
J
J
Serrand
P
P
Binet
J L
JL
Grosset
J
J
Thuillier
A
A
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D007938:Leukemia / Q000097:blood / Q000188:drug therapy; D008223:Lymphoma / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000150:complications*; D017334:Teicoplanin / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D017334:Teicoplanin