Induction of drug-metabolizing enzymes by dioxin.
Whitlock
J P
JP
Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305-5332, USA.
Chichester
C H
CH
Bedgood
R M
RM
Okino
S T
ST
Ko
H P
HP
Ma
Q
Q
Dong
L
L
Li
H
H
Clarke-Katzenberg
R
R
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D051792:Basic Helix-Loop-Helix Proteins; D002843:Chromatin; D019363:Cytochrome P-450 CYP1A1 / Q000096:biosynthesis / Q000187:drug effects* / Q000235:genetics; D019388:Cytochrome P-450 CYP1A2 / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism; D004147:Dioxins / Q000494:pharmacology*; D004742:Enhancer Elements, Genetic / Q000235:genetics; D004790:Enzyme Induction; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D005982:Glutathione Transferase / Q000096:biosynthesis / Q000187:drug effects; D008297:Male; D009247:NADH, NADPH Oxidoreductases / Q000096:biosynthesis / Q000187:drug effects; D004364:Pharmaceutical Preparations / Q000378:metabolism; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D011401:Promoter Regions, Genetic / Q000235:genetics; D051381:Rats; D018336:Receptors, Aryl Hydrocarbon; D014157:Transcription Factors / Q000378:metabolism; D015533:Transcriptional Activation
D001189:Aryl Hydrocarbon Hydroxylases; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D051792:Basic Helix-Loop-Helix Proteins; D002843:Chromatin; D019363:Cytochrome P-450 CYP1A1; D019388:Cytochrome P-450 CYP1A2; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System; D004268:DNA-Binding Proteins; D004147:Dioxins; D005982:Glutathione Transferase; D009247:NADH, NADPH Oxidoreductases; D004364:Pharmaceutical Preparations; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D014157:Transcription Factors; C497398:ARNT protein, rat; C585499:Cyp1b1 protein, rat