title: Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses.
abstract: The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.
authors.affiliation: Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: C
authors.initials: C
authors.lastname: Parolin
authors.forename: A
authors.initials: A
authors.lastname: Borsetti
authors.forename: H
authors.initials: H
authors.lastname: Choe
authors.forename: M
authors.initials: M
authors.lastname: Farzan
authors.forename: P
authors.initials: P
authors.lastname: Kolchinsky
authors.forename: M
authors.initials: M
authors.lastname: Heesen
authors.forename: Q
authors.initials: Q
authors.lastname: Ma
authors.forename: C
authors.initials: C
authors.lastname: Gerard
authors.forename: G
authors.initials: G
authors.lastname: Palú
authors.forename: M E
authors.initials: ME
authors.lastname: Dorf
authors.forename: T
authors.initials: T
authors.lastname: Springer
authors.forename: J
authors.initials: J
authors.lastname: Sodroski
mesh_terms: D000818:Animals; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D051379:Mice; D054398:Receptors, CCR4; D019707:Receptors, Chemokine / Q000502:physiology*; D011991:Receptors, Virus / Q000502:physiology*; D013601:T-Lymphocytes / Q000821:virology*; D014779:Virus Replication
chemical_list: C515354:CCR4 protein, human; C515355:Ccr4 protein, mouse; D054398:Receptors, CCR4; D019707:Receptors, Chemokine; D011991:Receptors, Virus