title: Diagnosis of Crohn's ileitis and monitoring of disease activity: value of Doppler ultrasound of superior mesenteric artery flow.
abstract: OBJECTIVE
  To assess the value of measurements of superior mesenteric artery flow using Doppler ultrasound for detecting disease activity in patients with proven or suspected Crohn's disease.
  
  
  METHODS
  Superior mesenteric artery flow was measured prospectively in 31 patients with known or suspected small-bowel disease. Sixteen patients were known to suffer from Crohn's disease and were suspected of having active disease. Fifteen patients had abdominal complaints without a specific diagnosis. Enteroclysis was used as the standard of reference to detect Crohn's disease, to define the location of small-bowel Crohn's disease, and to assess disease activity by demonstrating cobblestoning. Disease activity was further substantiated by clinical signs, laboratory values, and clinical follow-up.
  
  
  RESULTS
  Ten patients with active disease on enteroclysis made up group 1. Group 2 comprised nine patients known to have Crohn's disease but without active disease (inactive small-bowel disease). The remaining 12 patients made up group 3. In group 1, the flow volume values were significantly higher than those in group 2 and group 3: 738 +/- 411 (mean +/- SD) versus 364 +/- 101 and 300 +/- 91, respectively (p < 0.05).
  
  
  CONCLUSIONS
  Whereas the initial diagnosis of small-bowel involvement in Crohn's disease may rely on enteroclysis, Doppler measurements of superior mesenteric artery flow are useful to monitor the activity of Crohn's disease.
authors.affiliation: Department of Diagnostic Radiology, Leiden University Medical Center, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: van Oostayen
authors.forename: M N
authors.initials: MN
authors.lastname: Wasser
authors.forename: G
authors.initials: G
authors.lastname: Griffioen
authors.forename: R A
authors.initials: RA
authors.lastname: van Hogezand
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
authors.forename: A
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D003424:Crohn Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D004724:Endoscopy; D005260:Female; D006801:Humans; D007079:Ileitis / Q000175:diagnosis / Q000000981:diagnostic imaging; D007421:Intestine, Small / Q000000981:diagnostic imaging; D008297:Male; D017538:Mesenteric Artery, Superior / Q000000981:diagnostic imaging* / Q000502:physiology; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D018608:Ultrasonography, Doppler