Modeling age of onset and residual familial correlations for the linkage analysis of bipolar disorder.
We applied regressive modeling to the data described by Stine et al. [1995] and further explored the possible linkage of bipolar disorder to marker D18S41 on chromosome 18. We performed analyses to determine age-dependent penetrance functions that best fit the data and that allow for residual familial correlations. Specifically, we introduce here a simple method to allow for a sibling correlations. that is not due to segregation at the linked locus, and then extend the results of Stine et al. [1995] by using the best fitting "regressive" model of this kind as input into a lod score linkage analysis. Although a formal segregation analysis was not attempted, a surprising finding was that, except for doubtful linkage to D18S41, there is little evidence for genetic transmission of bipolar disorder in these families.
Schnell
A H
AH
Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, Ohio 44109, USA.
Karunaratne
P M
PM
Witte
J S
JS
Dawson
D V
DV
Elston
R C
RC
D017668:Age of Onset; D001714:Bipolar Disorder / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical; D009679:Nuclear Family; D012044:Regression Analysis