[Effects of calcium supplementation using AAACa or milk on nocturnal bone resorption in young women].
In order to study the effect of calcium supplementation on bone resorption, a randomized controlled crossover study was carried out on eight healthy 18-19 year old female volunteers using either AAACa heated oyster shell with vacuum-heated seaweed or milk. Regimen A consisted of an oral dose of 200 mg calcium in the form of AAACa. B 200 ml milk after breakfast and supper and at bedtime, and C control with no calcium supplement. Early morning fasting blood and urine sampling was carried out after 7 days of calcium supplementation. Serum calcium was higher in groups A and B than in C, and serum intact parathyroid hormone (PTH) was significantly lower in group A than in groups B and C, according to a paired t-test. Urinary excretion of crosslinked collagen degradation product, pyridinoline and deoxypyridinoline showed a similar decrease in groups A and B but not in C. The more effective suppression of PTH by AAACa than by milk may be due to its higher bioavailability and the absence of phosphate stimulating PTH secretion.
Ohgitani
S
S
Department of Clinical Laboratories, National Sanatorium Hyogo Chuo Hospital.
Fujii
Y
Y
Fujita
T
T
D000293:Adolescent; D000328:Adult; D000818:Animals; D001862:Bone Resorption / Q000517:prevention & control*; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002136:Calcium, Dietary / Q000008:administration & dosage*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008892:Milk; D010024:Osteoporosis / Q000517:prevention & control; D010281:Parathyroid Hormone / Q000097:blood
D002136:Calcium, Dietary; D010281:Parathyroid Hormone; D002118:Calcium