title: Age-related changes of the mechanical properties of the carotid artery in spontaneously hypertensive rats.
abstract: BACKGROUND
  We had previously demonstrated that the distensibility of the carotid artery in spontaneously hypertensive rats (SHR) aged 18 weeks does not differ from that of the carotid artery in normotensive animals for common pressure levels, despite vascular hypertrophy in SHR.
  
  
  OBJECTIVE
  To examine the time-course effects of hypertension on the geometry and the mechanical properties of the carotid artery in SHR.
  
  
  METHODS
  The mechanical behavior of the carotid arteries of anesthetized SHR, stroke-prone SHR (SHRSP), and Wistar-Kyoto (WKY) rats aged 4, 8, 12, 16, and 32 weeks was examined by simultaneously measuring the internal diameter with an A-mode ultrasonic echo-tracking device and the intra-arterial pressure with a computerized data-acquisition system. Histometric measurements of the carotid artery were performed after death of rats.
  
  
  RESULTS
  Blood pressure increased with time in rats of the two genetic hypertensive models. However, it rose earlier and to higher levels in the SHRSP. Cardiac hypertrophy was comparable in the two hypertensive groups whereas vascular hypertrophy was less pronounced in the SHRSP than it was in the SHR. There was an age-related decrease in arterial distensibility in rats of all groups that was more pronounced in the SHRSP than it was in the SHR compared with that in WKY rats (decreases of 57 and 36%, respectively, versus WKY rats aged 32 weeks; P < 0.05). For rats of all ages studied, although aging affected differently the vascular properties of the distinct animal strains, arterial distensibility was increased in the SHR and SHRSP compared with that in control animals for similar blood pressure levels, implying a rightward shift of the distensibility-pressure curves in the two hypertensive models. However, there was a significant reduction in arterial distensibility in rats of the two hypertensive strains at their respective mean blood pressures, compared with that in control animals.
authors.affiliation: Division of Hypertension and Vascular Medicine, University Hospital, Lausanne, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Zanchi
authors.forename: H R
authors.initials: HR
authors.lastname: Brunner
authors.forename: D
authors.initials: D
authors.lastname: Hayoz
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000235:genetics; D003187:Compliance; D020022:Genetic Predisposition to Disease; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics / Q000502:physiology*; D011921:Rats, Inbred WKY; D012016:Reference Values