Cholesterol and atherosclerosis.
Cholesterol is an essential component of cellular membranes, but when present in excess in the circulation, can be deposited in the arterial wall, leading to the formation of atherosclerotic lesions. The principal plasma carrier of cholesterol, low density lipoprotein (LDL), is removed from the circulation by LDL receptors in the liver. This process plays a critical role in regulating plasma LDL levels. The unique structure and composition of the LDL particle makes it particularly susceptible to modification by oxidative reactions. Current evidence suggests that the production of oxidised LDL in the intima, and the removal of oxidised LDL particles by scavenger receptors on macrophages, play a central role in the development and progression of atherosclerotic lesions.
Kroon
P A
PA
Department of Biochemistry, University of Queensland, Brisbane.
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000096:biosynthesis / Q000097:blood*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000097:blood / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000096:biosynthesis / Q000097:blood; D011973:Receptors, LDL / Q000097:blood
D015415:Biomarkers; D004791:Enzyme Inhibitors; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases