[Telomere and telomerase associated genes].
Telomerase is a ribonucleoprotein, telomere specific reverse transcriptase, which contains some protein components and telomerase RNA components. Human telomerase RNA and some telomerase components have been identified but not completely. More recently, human telomerase catarytic subunits have been cloned, which are called hTRT or hEST2. The expression of hTRT in human cultured cells is well correlated with telomerase activity and immortality. Moreover, the expression of hTRT in cancer tissues is higher than that of normal tissues. These results suggested that hTRT and telomerase activity may be a powerful additional tool for cancer diagnosis.
Tahara
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Dept. of Cellular and Molecular Biology, Hiroshima University School of Medicine, Japan.
Tahara
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Tahara
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D004268:DNA-Binding Proteins; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D012313:RNA; D019098:Telomerase / Q000235:genetics* / Q000378:metabolism; D016615:Telomere / Q000235:genetics*; D014407:Tumor Cells, Cultured
D004268:DNA-Binding Proteins; D011506:Proteins; C422952:telomerase RNA; D012313:RNA; C509186:TERT protein, human; D019098:Telomerase