Acute tubulointerstitial nephritis associated with piperacillin therapy in a boy with glomerulonephritis.
An 11-year-old boy with glomerulonephritis developed acute renal failure 4 days after beginning piperacillin (PIPC) treatment. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN) with marked eosinophils. A lymphocyte stimulation test (LST) for PIPC demonstrated an extremely high LST index of 626%. The serum levels of immunoglobulin E and eosinophil cationic protein also showed a significant increase at 9021 IU/mL and greater than 150 micrograms/L, respectively. These observations suggest that a hypersensitivity reaction might play a role in the pathogenesis of ATIN. This is the first report to describe PIPC-induced ATIN in a child.
Tanaka
H
H
Department of Pediatrics, Hirosaki University School of Medicine, Japan.
Waga
S
S
Kakizaki
Y
Y
Tateyama
T
T
Koda
M
M
Yokoyama
M
M
D000208:Acute Disease; D002648:Child; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D010406:Penicillins / Q000009:adverse effects*; D010878:Piperacillin / Q000009:adverse effects*
D010406:Penicillins; D010878:Piperacillin