title: Involvement of an efflux system in high-level fluoroquinolone resistance of Shigella dysenteriae.
abstract: Shigella dysenteriae represent one of the growing list of antibiotic-resistant bacteria. Quinolones are widely employed to treat shigellosis. However, quinolone resistance has already been reported, necessitating an understanding of the mechanisms of development of resistance. We demonstrate that high-level fluoroquinolone resistance of S. dysenteriae exposed to these antibiotics may occur in the absence of gyrA mutations and involve a proton motive force(pmf)-dependent efflux system.
authors.affiliation: Department of Chemistry, Bose Institute, Calcutta, India.
authors.forename: A S
authors.initials: AS
authors.lastname: Ghosh
authors.forename: J
authors.initials: J
authors.lastname: Ahamed
authors.forename: K K
authors.initials: KK
authors.lastname: Chauhan
authors.forename: M
authors.initials: M
authors.lastname: Kundu
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism; D000890:Anti-Infective Agents / Q000378:metabolism / Q000494:pharmacology*; D001692:Biological Transport; D002463:Cell Membrane Permeability; D002701:Chloramphenicol / Q000378:metabolism; D002939:Ciprofloxacin / Q000378:metabolism; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II / Q000235:genetics; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D012762:Shigella dysenteriae / Q000187:drug effects*; D013752:Tetracycline / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D002701:Chloramphenicol; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II; D013752:Tetracycline