title: Effects of transitory cognitive impairment on psychosocial functioning of children with epilepsy: a therapeutic trial.
abstract: The authors report a trial of the use of anti-epileptic medication to treat possible cognitive deficits due to subclinical epileptiform EEG discharges in 10 children with psychosocial and educational problems associated with epilepsy. Medication intended to suppress the EEG discharges was added to the children's existing drug regime. In all instances, epileptiform activity, assessed by 24-hour periods of ambulatory monitoring, was reduced on active medication compared with placebo. In general, there was improvement of psychosocial function on active treatment: eight children improved, there was no change in one and one deteriorated. No psychosocial deterioration attributable to adverse effects of the medication was detected in those completing the trial. Despite possible confounding factors, the findings are in accordance with the view that subclinical EEG discharges can impair psychosocial function, which may be ameliorated by anti-epileptic medication.
authors.affiliation: Maudsley Hospital, London.
authors.forename: D
authors.initials: D
authors.lastname: Marston
authors.forename: F
authors.initials: F
authors.lastname: Besag
authors.forename: C D
authors.initials: CD
authors.lastname: Binnie
authors.forename: M
authors.initials: M
authors.lastname: Fowler
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D003072:Cognition Disorders / Q000188:drug therapy* / Q000523:psychology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology / Q000523:psychology*; D012920:Social Behavior Disorders / Q000188:drug therapy
chemical_list: D000927:Anticonvulsants