An evaluation of prognostic factors in uterine carcinosarcoma.
The traditional clinical and histopathological prognostic variables and DNA ploidy were analyzed in 46 patients with histologically verified uterine carcinosarcoma. Twenty-three tumors were of the homologous and 23 of the heterologous type. Evaluable flow cytometric DNA histograms from paraffin-embedded tumor tissue were obtained in 39 patients. The overall 5-year cancer related survival was 31%. All tumors were of high malignancy grade. In univariate analysis of survival, extrauterine spread of tumor (P = 0.007), age (P = 0.008), and tumor diameter (P = 0.04) obtained statistical significance. Tumors with components of serous or clear cell carcinomas had a less favorable prognosis (P = 0.017). There was no difference in survival between patients with homologous and heterologous tumors (P = 0.39). Mitotic count, vessel invasion, and DNA ploidy did not obtain prognostic significance. In Cox multivariate analysis, extrauterine spread of tumor (P = 0.004) and age (P = 0.004) were found to be the most important prognostic factors followed by content of serous or clear cell carcinoma components (P = 0.027).
Nordal
R R
RR
Department of Gynecologic Oncology, Pathology, and Cell Biology, Norwegian Radium Hospital, University of Oslo, Montebello, Norway.
Kristensen
G B
GB
Stenwig
A E
AE
Nesland
J M
JM
Pettersen
E O
EO
Trope
C G
CG
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002296:Carcinosarcoma / Q000175:diagnosis* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010298:Parity; D011003:Ploidies; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology
D004273:DNA, Neoplasm