Magnetic resonance spectroscopy of isoflurane kinetics in humans. Part I: Elimination from the head.
We describe the first human experiments to demonstrate wash-out of isoflurane using fluorine magnetic resonance spectroscopy. Using a surface receive coil, we found two-compartment kinetics within the head with decay half-times of 9.5 and 130 min, but the signal was too weak to localize the compartments. If the fast compartment is assumed to be the brain then our results match the predictions of the classical perfusion-limited pharmacokinetic model of inhalation anaesthesia.
Lockwood
G G
GG
Department of Anaesthesia, Hammersmith Hospital, London.
Dob
D P
DP
Bryant
D J
DJ
Wilson
J A
JA
Sargentoni
J
J
Sapsed-Byrne
S M
SM
Harris
D N
DN
Menon
D K
DK
D000328:Adult; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism*; D005461:Fluorine; D006801:Humans; D007530:Isoflurane / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy
D018685:Anesthetics, Inhalation; D005461:Fluorine; D007530:Isoflurane