title: First trimester pregnancy loss associated with varicella zoster virus infection: histological definition of a case.
abstract: Pathological demonstration of varicella infection in first trimester aborted tissue is reported. A 24-year-old primigravida manifested chickenpox infection about 38 days after her last menstrual period or at 24 days age of the embryo. The conceptus survived another 4 to 5 weeks. The macerated embryo and placental tissue revealed nuclear changes consistent with varicella infection. Immunohistochemical stains and electron microscopy were confirmatory.
authors.affiliation: Department of Pathology, Women and Infants' Hospital and Brown University School of Medicine, Providence, RI 02905, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Oyer
authors.forename: R
authors.initials: R
authors.lastname: Cai
authors.forename: J J
authors.initials: JJ
authors.lastname: Coughlin
authors.forename: D B
authors.initials: DB
authors.lastname: Singer
mesh_terms: D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D002644:Chickenpox / Q000473:pathology* / Q000635:transmission*; D002824:Chorionic Villi / Q000648:ultrastructure / Q000821:virology; D005260:Female; D005313:Fetal Death / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008854:Microscopy, Electron; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D011261:Pregnancy Trimester, First
chemical_list: D000956:Antigens, Viral