Tuberculous pericardial effusion: a prospective clinical study in a low-resource setting--Blantyre, Malawi.
METHODS
Queen Elizabeth Central Hospital, Blantyre, Malawi.


OBJECTIVE
Review of clinical and investigation findings and outcome, using a standard management protocol, in human immunodeficiency virus (HIV)-positive and HIV-negative patients with tuberculous pericardial effusion, in a low-resource setting in sub-Saharan Africa.


METHODS
A prospective study under field conditions of adult patients with tuberculous pericardial effusion admitted to Queen Elizabeth Central Hospital between May 1993 and December 1994.


RESULTS
In total 77 patients fulfilled the diagnostic criteria for tuberculous pericardial effusion. Of 74 patients sero-tested, 68 (92%) were HIV seropositive. Classical clinical features of pericardial effusion were often absent. Many patients had no other clinical features of HIV infection. Outcome compared favourably with quoted survival rates from the pre-HIV era.


CONCLUSIONS
Tuberculous pericardial effusion is a common problem in Blantyre and is strongly associated with HIV infection. Successful management using a standard protocol is possible in a low-resource setting.
Maher
D
D
Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland. maherd@who.ch
Harries
A D
AD
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D003906:Developing Countries; D005260:Female; D006295:Health Resources / Q000706:statistics & numerical data; D006767:Hospitals, District / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008295:Malawi / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010343:Patient Admission / Q000706:statistics & numerical data; D010490:Pericardial Effusion / Q000188:drug therapy / Q000453:epidemiology*; D010495:Pericarditis, Tuberculous / Q000188:drug therapy / Q000453:epidemiology*; D016896:Treatment Outcome
D000995:Antitubercular Agents