Pharmacokinetic assessment of an oligopeptide-based enteral formula in abdominal surgery patients.
The specific effect of the molecular form of the nitrogen supply (oligopeptides and whole proteins) on amino acid kinetics during enteral feeding after surgery has not been assessed previously. In a prospective, randomized study, patients having undergone esophagectomy or gastrectomy for cancer received jejunal infusions of oligopeptide-based or whole-protein-based complete formulas (OPD and WPD, respectively) during two 9-h periods on 2 consecutive days in a crossover design. The OPD and WPD had identical energy compositions and amino acid profiles. Amino acid peripheral bioavailability (measurements of area under the curve of arterial blood concentrations), amino acid arteriovenous differences, and insulin and glucagon responses were measured. Amino acid peripheral bioavailability was higher (leucine: 54%, P < 0.01; essential amino acids: 48%, P < 0.01; total amino acids: 53%, P < 0.02) and peripheral appearance of amino acids was more homogeneous (variation around the calculated plateau of plasma leucine was 39% for OPD and 78% for WPD, P < 0.001) with the OPD than with the WPD. With the OPD, insulin stimulation was faster and plasma concentrations of leucine and insulin were correlated (r = 0.77, P < 0.01). The OPD led to a higher amino acid peripheral bioavailability than the corresponding WPD. These results could be useful for a better definition of clinical indications of semi-elemental diets.
Ziegler
F
F
Biochemistry Laboratory, Saint Antoine Hospital, Paris, France.
Nitenberg
G
G
Coudray-Lucas
C
C
Lasser
P
P
Giboudeau
J
J
Cynober
L
L
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood* / Q000493:pharmacokinetics; D001682:Biological Availability; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D005526:Food, Formulated; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007930:Leucine / Q000097:blood* / Q000378:metabolism; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011446:Prospective Studies; D013997:Time Factors
D000596:Amino Acids; D007328:Insulin; D009842:Oligopeptides; D007930:Leucine