Acute retinal necrosis late in the second trimester.
OBJECTIVE
To report treatment of a patient with acute retinal necrosis during pregnancy.


METHODS
A 24-year-old woman in her twenty-third week of gestation was diagnosed with acute retinal necrosis. A combination of acyclovir and interferon therapy was started at 25 weeks. Pars plana vitrectomy was performed during the 26th week of gestation.


RESULTS
The necrotizing retina became gliotic within 3 weeks of surgery. The patient's visual acuity improved to LE, 20/40. A healthy baby was delivered at 39 weeks of gestation.


CONCLUSIONS
Combination therapy of acyclovir and interferon followed by surgery partially restored the patient's vision without affecting fetal development.
Shiraki
K
K
Department of Ophthalmology, Osaka City University Medical School, Japan. shirakik@msci.med.osaka-cu.ac.jp
Moriwaki
M
M
Ataka
S
S
Henmi
K
K
Miki
T
T
Kanaoka
Y
Y
D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004279:DNA, Viral / Q000032:analysis; D004359:Drug Therapy, Combination; D015828:Eye Infections, Viral / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D005260:Female; D005865:Gestational Age; D006561:Herpes Simplex / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D015882:Retinal Necrosis Syndrome, Acute / Q000503:physiopathology / Q000628:therapy* / Q000821:virology; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy; D014822:Vitreous Body / Q000821:virology
D000998:Antiviral Agents; D004279:DNA, Viral; D016899:Interferon-beta; D000212:Acyclovir