Probabilistic diagnosis in linkage analysis of bipolar disorder: putting weights on the fringe.
We explored the utility of probabilistic weighting of fringe phenotypes in linkage analysis of bipolar disorder for the GAW10 chromosome 18 data. Four liability classes were assigned probabilistic weights based on the estimated probability that the case was a true bipolar. The weights were incorporated in parametric and nonparametric, single and multipoint analyses.
Van Eerdewegh
P
P
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Santangelo
S L
SL
Lee
H
H
Laird
N M
NM
Blacker
D
D
D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D015995:Prevalence; D011336:Probability; D012307:Risk Factors; D018709:Statistics, Nonparametric