title: Immunohistochemical detection of human milk components aspirated in lungs of an infant.
abstract: We examined an autopsy case of an infant whose cause of death was suspected to be asphyxia due to human breast milk aspiration. In order to demonstrate aspirated milk in the lungs, we conducted immunohistochemical staining using eight antibodies against the components of human milk. Seven of the eight antibodies reacted positively with the substances suspected to be aspirated milk. We concluded that immunohistochemical staining with these antibodies is useful to demonstrate human milk aspiration and provide some keys for detecting the causes of unexpected infant deaths.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwadate
authors.forename: N
authors.initials: N
authors.lastname: Sakamoto
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: M
authors.initials: M
authors.lastname: Doy
authors.forename: H
authors.initials: H
authors.lastname: Iwase
authors.forename: M
authors.initials: M
authors.lastname: Nagao
authors.forename: T
authors.initials: T
authors.lastname: Takatori
mesh_terms: D001344:Autopsy / Q000379:methods*; D002423:Cause of Death; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology*; D008297:Male; D008895:Milk, Human / Q000737:chemistry*; D011015:Pneumonia, Aspiration / Q000209:etiology / Q000473:pathology*