title: [Acute hepatitis following amiodarone administration].
abstract: A 61 year old man, treated with amiodarone since 1993 for resistant supraventricular arrhythmias, developed acute hepatitis after an intravenous amiodarone administration. Kidney and liver function tests were performed and pointed out abnormal results. Symptoms ascribable to hepatotoxicity were absent. These changes returned to normal levels within 20 days from withdrawal of the drug. Amiodarone hepatotoxicity can be related to prolonged therapy with a high dose. Intravenous amiodarone may cause acute hepatic disease, but it is suggested that polysorbate 80, a solvent added to the intravenous infusion, is a more likely cause of this complication.
authors.affiliation: Cattedra di Cardiologia, II Università degli Studi, Napoli.
authors.forename: E
authors.initials: E
authors.lastname: Tagliamonte
authors.forename: G
authors.initials: G
authors.lastname: Cice
authors.forename: V
authors.initials: V
authors.lastname: Ducceschi
authors.forename: M S
authors.initials: MS
authors.lastname: Mayer
authors.forename: A
authors.initials: A
authors.lastname: Iacono
mesh_terms: D000208:Acute Disease; D000638:Amiodarone / Q000009:adverse effects / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*
chemical_list: D000638:Amiodarone