Antipsychotic agents and bipolar disorder.
Antipsychotic agents have been used commonly in the treatment of bipolar disorder. This article reviews the evolution of the use of antipsychotic agents and their role in the acute and maintenance treatment of bipolar disorder. The focus is on neuroleptic drugs, the atypical antipsychotic drugs (risperidone and clozapine), and two fo the new atypical antipsychotic drugs that were recently approved.
Tohen
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Bipolar and Psychotic Disorders Program, McLean Hospital, Belmont, MA 02178, USA.
Zarate
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CA
D000208:Acute Disease; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D003024:Clozapine / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy; D018967:Risperidone / Q000627:therapeutic use; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D001569:Benzodiazepines; D010890:Pirenzepine; D008094:Lithium; D003024:Clozapine; D018967:Risperidone; D000077152:Olanzapine