Structure and dynamics of green fluorescent protein.
Many marine organisms are luminescent. The proteins that produce the light include a primary light producer (aequorin or luciferase) and often a secondary photoprotein that red shifts the light for better penetration in the ocean. Green fluorescent protein is one such secondary protein. It is remarkable in that it autocatalyzes the formation of its own fluorophore and thus can be expressed in a variety of organisms in its fluorescent form. The recent determination of its 3D structure and other physical characterizations are revealing its molecular mechanism of action.
Phillips
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Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005-1892, USA. georgep@rice.edu
D000818:Animals; D018360:Crystallography, X-Ray; D019281:Dimerization; D049452:Green Fluorescent Proteins; D006860:Hydrogen Bonding; D008163:Luminescent Measurements; D008164:Luminescent Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation; D015202:Protein Engineering; D017433:Protein Structure, Secondary
D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins