Axon guidance: GTPases help axons reach their targets.
During development and regeneration of the nervous system, axons must correctly navigate to their specific targets through a complex molecular environment. Recent work has shed light on how GTPases of the Ras family are involved in transducing extracellular signals into responses that lead to directed neurite outgrowth.
Gallo
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Department of Cell Biology and Neuroanatomy, 4-144 Jackson Hall, The University of Minnesota, Minneapolis, Minnesota 55455, USA.
Letourneau
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PC
D000818:Animals; D001369:Axons / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics; D018797:Cell Cycle Proteins / Q000502:physiology; D003712:Dendrites / Q000502:physiology; D004789:Enzyme Activation; D020558:GTP Phosphohydrolases / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology; D005810:Multigene Family; D009420:Nervous System / Q000254:growth & development*; D009447:Neuroblastoma / Q000473:pathology; D015398:Signal Transduction / Q000502:physiology*; D014407:Tumor Cells, Cultured; D020764:cdc42 GTP-Binding Protein; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins
D018797:Cell Cycle Proteins; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D020764:cdc42 GTP-Binding Protein; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins