Failure analysis in irradiated stage I testicular seminoma. Results of long-term follow-up (1968-1993).
A retrospective analysis of 81 stage I seminoma patients irradiated at the Northern Israel Oncology Center between 1968 and 1993 was undertaken. During this period, 5 (6%) patients relapsed, all outside the initial treatment volume, with a median time of 6.6 (range 1-12) months to relapse. Three patients were salvaged with cisplatin-based chemotherapy. The policy of adjuvant radiotherapy resulted in a high probability of cure and decreased relapse rate. Early relapse is a rare event in properly irradiated stage I seminoma which is highly curable with a cisplatin-containing regimen. Recurrences tend to occur outside the treated radiation volume.
Stein
M E
ME
Northern Israel Oncology Center, Rambam Medical Center, and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa. m-stein@rambam.health.gov.il
Drumea
K
K
Moshkowitz
B
B
Nativ
O
O
Kuten
A
A
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012189:Retrospective Studies; D016879:Salvage Therapy; D018239:Seminoma / Q000188:drug therapy / Q000532:radiotherapy*; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D017211:Treatment Failure; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D002945:Cisplatin