title: Treatment of recurrent conjunctival epithelial neoplasia with topical mitomycin C.
abstract: OBJECTIVE
  To study the effect of topical mitomycin C on conjunctival squamous neoplasia.
  
  
  METHODS
  Three patients with recurrent conjunctival epithelial neoplasia were treated with topical mitomycin C 0.04%.
  
  
  RESULTS
  Six to 9 months after treatment, no patient had clinical evidence of tumor recurrence. Conjunctival biopsy in two patients and cytology in one patient showed no evidence of tumor 1 to 4 months after treatment. One patient required short-term treatment for corneal edema and epithelial toxicity.
  
  
  CONCLUSIONS
  Topical mitomycin C caused tumor regression without recurrence for 6 to 9 months after treatment.
authors.affiliation: Bascom Palmer Eye Institute, Emory University, Atlanta, GA 30322, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Heigle
authors.forename: R D
authors.initials: RD
authors.lastname: Stulting
authors.forename: D A
authors.initials: DA
authors.lastname: Palay
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009883:Ophthalmic Solutions; D012008:Recurrence; D012074:Remission Induction
chemical_list: D000903:Antibiotics, Antineoplastic; D009883:Ophthalmic Solutions; D016685:Mitomycin