title: Adenovirus-induced liver necrosis in a case of AIDS.
abstract: Adenovirus-induced liver necrosis is rare. Because the era of AIDS (acquired immunodeficiency syndrome) this entity was seen predominantly in infants suffering from inborn immunodeficiency syndromes or from iatrogenic immunosuppression because of bone marrow or liver transplantation. Here, we report a case of a 30-year-old woman with AIDS who developed fever and rapidly progressing liver failure. A frozen section from a needle biopsy of the liver allowed a quick diagnosis of viral liver necrosis. The light-microscopic and electron microscopic aspects were typical of adenovirus infection and should be known to the surgical pathologist. The diagnosis was confirmed by immunohistochemistry and DNA hybridization analysis.
authors.affiliation: Pathologisches Institut, Universität Bonn, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Dombrowski
authors.forename: A M
authors.initials: AM
authors.lastname: Eis-Hübinger
authors.forename: T
authors.initials: T
authors.lastname: Ackermann
authors.forename: J
authors.initials: J
authors.lastname: Blümel
authors.forename: U
authors.initials: U
authors.lastname: Spengler
authors.forename: U
authors.initials: U
authors.lastname: Pfeifer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000256:Adenoviridae / Q000648:ultrastructure; D000257:Adenoviridae Infections / Q000150:complications* / Q000473:pathology; D000328:Adult; D001707:Biopsy, Needle; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure / Q000821:virology; D008854:Microscopy, Electron; D009336:Necrosis