Comparison of sib-pair and variance-components methods for genomic screening.
The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance-components method had better power for detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods.
Pugh
E W
EW
National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA.
Jaquish
C E
CE
Sorant
A J
AJ
Doetsch
J P
JP
Bailey-Wilson
J E
JE
Wilson
A F
AF
D000704:Analysis of Variance; D001331:Automation; D002874:Chromosome Mapping; D005260:Female; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D009679:Nuclear Family; D010641:Phenotype; D011237:Predictive Value of Tests
D005819:Genetic Markers