Relationships between cytoskeletal proteins and the toxic effects of drugs.
Many cell functions and aspects of cell configuration are linked with changes in cytoskeletal proteins, by intracellular signal transduction. Histochemical and pathophysiological changes caused by toxins or drugs affect on dynamic aspects of cytoskeletal proteins. Here we review that biochemical and molecular biological properties of the microtubules and microfilaments and the relationships between these cytoskeletal proteins and the toxic effects of drugs and toxins. The intracellular signaling pathway makes use of cytoskeletal proteins.
Tsuyama
S
S
Department of Veterinary Science, Osaka Prefecture University, Japan.
Takenaka
S
S
D008841:Actin Cytoskeleton / Q000187:drug effects*; D000818:Animals; D003598:Cytoskeletal Proteins / Q000648:ultrastructure; D064420:Drug-Related Side Effects and Adverse Reactions; D008870:Microtubules / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects
D003598:Cytoskeletal Proteins