title: The human FXY gene is located within Xp22.3: implications for evolution of the mammalian X chromosome.
abstract: It has been proposed that the pseudoautosomal region of mammals has evolved by sequential addition of autosomal material onto the X and Y chromosomes followed by movement of the pseudoautosomal boundary to create X-unique regions. We have previously described a gene, Fxy , that spans the pseudoautosomal boundary in mice such that the first three exons of the gene are located on the X chromosome, but the remainder of the gene is located on both X and Y chromosomes. Therefore, this gene might be in a state of transition between pseudoautosomal and X-unique locations. In support of this theory we show here that the human FXY gene is located in Xp22.3 in humans, proximal to the pseudoautosomal boundary.
authors.affiliation: CRC Centre for Cell and Molecular Biology and Section of Gene Function and Regulation, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.
authors.forename: J
authors.initials: J
authors.lastname: Perry
authors.forename: S
authors.initials: S
authors.lastname: Feather
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Palmer
authors.forename: A
authors.initials: A
authors.lastname: Ashworth
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D003001:Cloning, Molecular; D016384:Consensus Sequence; D004303:Dosage Compensation, Genetic; D019143:Evolution, Molecular; D005260:Female; D005326:Fetal Proteins / Q000096:biosynthesis; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008297:Male; D008322:Mammals / Q000235:genetics*; D051379:Mice / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D044767:Ubiquitin-Protein Ligases; D014960:X Chromosome / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics
chemical_list: D005326:Fetal Proteins; D011506:Proteins; C109037:Mid1 protein, mouse; D044767:Ubiquitin-Protein Ligases