title: Morphometric analyses of axons in the lateral corticospinal tract with ageing process.
abstract: Morphometric analyses were carried out to reveal a relation between age and axonal changes in the lateral corticospinal tract (LCST) at the L1 level of the human spinal cord. Histological preparations of the spinal cord were made after embedding in celloidin to stain with Luxol fast blue-periodic acid-Schiff-hematoxylin or Klüver-Barrera methods. The number, average transverse area, total area and diameter of axons of the LCST were counted and measured using an image-analyser combined with a computer. The morphometric analyses revealed that (1) there was a significant decrease in the axonal number of the LCST with age (p < 0.001); (2) the axons were not partially nor completely accompanied by surrounding myelin sheaths, and increased in number with age; (3) the diameter and average area of axons in the LCST became significantly reduced with age (p < 0.01); (4) the total area decreased significantly with age in a unit area of 2,700 microns2; and (5) the circularity ratio showed no significant change with age.
authors.affiliation: Department of Anatomy, Showa University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Zhou
authors.forename: N
authors.initials: N
authors.lastname: Goto
authors.forename: N
authors.initials: N
authors.lastname: Otsuka
authors.forename: H
authors.initials: H
authors.lastname: Moriyama
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001369:Axons / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D011712:Pyramidal Tracts / Q000473:pathology*