title: A new method to modify the C-4 position of 10-deacetylbaccatin III.
abstract: We have developed a new method to modify the C-4 position of 10-deacetylbaccatin III (5) using the C-4 acetoxy anion of the 13-keto derivative (7) and various alkyl halides. The method developed herein should be very useful for the preparation of C-4 modified taxoid analogs.
authors.affiliation: New Product Research Laboratories IV, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Uoto
authors.forename: H
authors.initials: H
authors.lastname: Takenoshita
authors.forename: T
authors.initials: T
authors.lastname: Ishiyama
authors.forename: H
authors.initials: H
authors.lastname: Terasawa
authors.forename: T
authors.initials: T
authors.lastname: Soga
mesh_terms: D000478:Alkylation; D017239:Paclitaxel / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D043823:Taxoids; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D043823:Taxoids; D014315:Triterpenes; C042213:10-deacetylbaccatine III; D017239:Paclitaxel