title: Thrombotic thrombocytopenic purpura in a patient with genetic haemochromatosis, liver cirrhosis and an iron-free focus.
abstract: We report a patient with thrombotic thrombocytopenic purpura and genetic haemochromatosis. The patient was shown by the polymerase chain reaction to be homozygous for the Cys282Tyr mutation of the HFE gene. Liver biopsy showed micronodular cirrhosis and the presence of an iron-free focus which was thought to be pre-neoplastic.
authors.affiliation: Department of Haematology, St George's Hospital Medical School, London.
authors.forename: S
authors.initials: S
authors.lastname: Killick
authors.forename: S
authors.initials: S
authors.lastname: Jeffery
authors.forename: M
authors.initials: M
authors.lastname: Otter
authors.forename: C
authors.initials: C
authors.lastname: Rist
authors.forename: D
authors.initials: D
authors.lastname: Bevan
mesh_terms: D000328:Adult; D003596:Cytosine / Q000378:metabolism; D006432:Hemochromatosis / Q000150:complications / Q000235:genetics*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D009154:Mutation; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications*; D014443:Tyrosine / Q000378:metabolism
chemical_list: D014443:Tyrosine; D003596:Cytosine