Local effect of PACAP and VIP on testicular function in immature and adult rats.
PACAP, VIP, anti-PACAP and anti-VIP antisera were injected intratesticularly. In 9-day-old hemicastrated rats PACAP or VIP decreased basal testosterone secretion. In 22-day-old hemicastrates VIP but not PACAP reduced compensatory testicular hypertrophy, however, neither PACAP nor VIP altered steroidogenesis. Anti-VIP antiserum to this age group increased testosterone production and enhanced compensatory testicular hypertrophy. In adult hemicastrates neither the peptides nor the antisera influenced steroidogenesis. Neither in immatures nor in adults treatment of both testes with PACAP or VIP had any effect. Data indicate that both PACAP and VIP might exert a local action on testicular steroidogenesis, on compensatory testicular hypertrophy, and these effects are age-dependent.
Csaba
Z
Z
Department of Human Morphology and Developmental Biology, Semmelweis University of Medicine, Budapest, Hungary.
Csernus
V
V
Gerendai
I
I
D000818:Animals; D000906:Antibodies / Q000276:immunology; D006984:Hypertrophy; D008297:Male; D009479:Neuropeptides / Q000276:immunology / Q000494:pharmacology*; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051381:Rats; D017207:Rats, Sprague-Dawley; D013256:Steroids / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D013739:Testosterone / Q000097:blood / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000276:immunology / Q000494:pharmacology*
C495403:Adcyap1 protein, rat; D000906:Antibodies; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D013256:Steroids; D014660:Vasoactive Intestinal Peptide; D013739:Testosterone