Molecular modelling and biological evaluation of a series of hydroxylated benzylideneanilines and benzylamines designed as tyrosine kinase inhibitors.
A series of hydroxylated benzylideneanilines and benzylamines were prepared and tested for inhibition of epidermal growth factor receptor-associated protein tyrosine kinase (PTK) activity in vitro. Molecular modelling and analysis of the biological results lead us to propose a minimal structural pharmacophore for two distinct binding sites within the PTK domain.
Solomons
K R
KR
Department of Chemistry, University of Wales Cardiff, UK.
Lieberman
H F
HF
Groundwater
P W
PW
Hibbs
D E
DE
Hursthouse
M B
MB
D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001596:Benzylamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001597:Benzylidene Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D018360:Crystallography, X-Ray; D008956:Models, Chemical; D047428:Protein Kinase Inhibitors; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D001596:Benzylamines; D001597:Benzylidene Compounds; D047428:Protein Kinase Inhibitors