title: Haemodynamic actions of insulin.
abstract: Several lines of evidence indicate a significant association between insulin and cardiovascular disease. This association might be explained by direct (cardio) vascular effects of insulin. Two hemodynamic actions of insulin are discussed in this review; it induces direct vasodilation in skeletal muscle and stimulation of the sympathetic nervous system. These closely linked effects normally offset each other. Although more insight has been obtained into responses in insulin-resistant individuals and possible mechanisms, direct evidence to support a causative role for insulin is not yet available.
authors.affiliation: Department of Medicine, University Hospital Nijmegen, The Netherlands. c.tack@aig.azn.nl
authors.forename: C J
authors.initials: CJ
authors.lastname: Tack
authors.forename: J W
authors.initials: JW
authors.lastname: Lenders
authors.forename: D S
authors.initials: DS
authors.lastname: Goldstein
authors.forename: J A
authors.initials: JA
authors.lastname: Lutterman
authors.forename: P
authors.initials: P
authors.lastname: Smits
authors.forename: T
authors.initials: T
authors.lastname: Thien
mesh_terms: D000818:Animals; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
chemical_list: D007328:Insulin