Effects of the isocarbacyclin methyl ester clinprost incorporated into lipid microspheres, in focal ischemia of stroke-prone spontaneously hypertensive rats.
The effects of TTC-909, the isocarbacyclin methyl ester clinprost (CAS 88931-51-5), incorporated into lipid microspheres, on ischemia-induced decrease in norepinephrine (NE) contents in stroke-prone spontaneously hypertensive rats (SHR-SP) with an occluded middle cerebral artery (MCA) were examined. Occluding of MCA led to infarction limited to the cerebral cortex and also a severe decrease in NE contents in peripheral regions of the infarction. TTC-909 was injected immediately after MCA occlusion, and then daily for 6 consecutive days. As TTC-909 in a dose of 200 ng/kg significantly (p < 0.05) prevented decreases in NE contents, TTC-909 may have cytoprotective effects on neuronal damage related to ischemia in humans.
Yae
T
T
Department of Pharmacology, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.
Araki
H
H
O-ogami
Y
Y
Iwasaki
K
K
Tanabe
H
H
Fujiwara
M
M
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002536:Cerebral Arteries / Q000502:physiology; D002544:Cerebral Infarction / Q000378:metabolism / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000503:physiopathology; D011464:Epoprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008863:Microspheres; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR
C068518:TTC 909; D011464:Epoprostenol; D009638:Norepinephrine