title: Arrhythmic cardiac arrest due to isolated coronary artery spasm: long-term outcome of seven resuscitated patients.
abstract: OBJECTIVE
  Our aim was to look at the clinical features and long-term follow-up of seven patients without coronary artery disease, who had a history of life-threatening ventricular arrhythmias due to coronary spasm.
  
  
  BACKGROUND
  Arrhythmic cardiac arrest due to isolated coronary spasm is rare, and there is limited information on the patients affected by this entity alone.
  
  
  METHODS
  The seven patients were recruited retrospectively from a cohort of survivors of cardiac arrest. None had a history of angina pectoris, structural heart disease or significantly narrowed coronary segments. All had a positive ergonovine provocation test result.
  
  
  RESULTS
  The patients' mean age was 44 years; three were male and four female. All were habitual cigarette smokers. No arrhythmias were induced on programmed ventricular stimulation; corrected QT interval (QTc) and corrected JT interval (JTc) dispersion were within normal ranges. After the ergonovine provocation test, treatment with calcium channel blocking agents (diltiazem, verapamil, nifedipine or amlodipine) was initiated at a dose determined by titration until a negative test result was obtained. At a mean follow-up interval of 58 months for the total group, six patients remained free of symptoms, whereas the one patient who did not stop smoking had a new cardiac arrest despite treatment for coronary spasm.
  
  
  CONCLUSIONS
  A favorable long-term outcome may be expected in survivors of cardiac arrest due to coronary spasm, in the absence of significant coronary artery disease. Calcium channel blockers are the most appropriate therapy in these patients. These observations provide further evidence for the role of silent ischemia in cardiovascular death.
authors.affiliation: Hôpital Cardiologique, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Chevalier
authors.forename: A
authors.initials: A
authors.lastname: Dacosta
authors.forename: P
authors.initials: P
authors.lastname: Defaye
authors.forename: T
authors.initials: T
authors.lastname: Chalvidan
authors.forename: E
authors.initials: E
authors.lastname: Bonnefoy
authors.forename: G
authors.initials: G
authors.lastname: Kirkorian
authors.forename: K
authors.initials: K
authors.lastname: Isaaz
authors.forename: B
authors.initials: B
authors.lastname: Denis
authors.forename: P
authors.initials: P
authors.lastname: Touboul
mesh_terms: D000328:Adult; D003329:Coronary Vasospasm / Q000150:complications*; D005260:Female; D006323:Heart Arrest / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012151:Resuscitation; D012189:Retrospective Studies; D012907:Smoking; D013610:Tachycardia / Q000209:etiology*; D016896:Treatment Outcome; D014693:Ventricular Fibrillation / Q000209:etiology