Epstein-Barr virus in B-cell lymphomas associated with chronic suppurative inflammation.
Chronic antigenic stimulation is considered to play an important role in neoplastic lymphoid transformation. This paper describes three cases of non-Hodgkin lymphomas (NHLs) associated with long-standing chronic suppuration. Two were primary bone lymphomas associated with long-standing chronic osteomyelitis and one was a primary skin lymphoma associated with chronic venous ulcers with a latent period of 13 years. All were diffuse large B-cell lymphomas, with plasmacytoid differentiation in two cases. Epstein-Barr virus (EBV)-encoded RNAs were demonstrated in virtually all tumour cells in all cases by in situ hybridization. Immunohistochemistry revealed EBV-encoded latent membrane protein (LMP)-1 expression in one case and BZLF1 protein expression in all three cases, whilst the EBV-encoded nuclear antigen (EBNA)-2 was not detected. Kaposi's sarcoma-associated herpesvirus (KSHV) sequences were absent in two cases studied. Our cases show similarities with pyothorax-associated pleural lymphomas reported mainly from Japan and recently from France, which are invariably associated with EBV. These findings suggest a causal effect of EBV in the development of this type of lymphoma complicating long-standing chronic suppuration. Localized immunodepression induced by chronic inflammation or immunosuppressive cytokines may favour the clonal proliferation of EBV-infected B cells.
Copie-Bergman
C
C
Department of Histopathology, UCL Medical School, London, U.K.
Niedobitek
G
G
Mangham
D C
DC
Selves
J
J
Baloch
K
K
Diss
T C
TC
Knowles
D N
DN
Delsol
G
G
Isaacson
P G
PG
D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications* / Q000473:pathology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology; D014647:Varicose Ulcer / Q000150:complications
D012367:RNA, Viral