title: [6-sulfatoxymelatonin in women with secondary amenorrhea].
abstract: We evaluated the overnight urinary excretion of 6-sulfatoxymelatonin in a group of 347 women (range: 18-69 years). 26 women (range 20-29 years) with normogonadotrophic, hypoestrogenemic amenorrhoea (WHO II) were selected and compared with a group of 26 women menstruating normally (range: 19-30 years) with respect to urinary 6-sulfatoxymelatonin excretion, serum 17 beta-estradiol levels and response to the thyroid releasing hormone (TRH) test. Patients with hyperprolactinemia, hyperandrogenemia, thyroid dysfunction and weight problems were excluded. 6-sulfatoxymelatonin was found to be significantly higher in the amenorrhoeic women than in the controls (p < 0.000001). In the amenorrhoeic patients a statistically significant inverse correlation was found between serum 17 beta-estradiol levels and urinary 6-sulfatoxymelatonin excretion. A positive correlation was obtained between the thyroid stimulation hormone (TSH) value measured at 20 minutes after stimulation and 6-sulfatoxymelatonin excretion. Further clinical research in this field is required to evaluate its clinical impact, especially in patients with secondary amenorrhea.
authors.affiliation: Klinische Abteilung für Gynäkologische Endokrinologie und Sterilitätsbehandlung, Universitätsklinik für Frauenheilkunde, AKH Wien, Osterreich.
authors.forename: D M
authors.initials: DM
authors.lastname: Gruber
authors.forename: C
authors.initials: C
authors.lastname: Schneeberger
authors.forename: T
authors.initials: T
authors.lastname: Laml
authors.forename: M O
authors.initials: MO
authors.lastname: Sator
authors.forename: J C
authors.initials: JC
authors.lastname: Huber
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000568:Amenorrhea / Q000209:etiology / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D008875:Middle Aged; D010870:Pineal Gland / Q000503:physiopathology; D012016:Reference Values; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
chemical_list: C054513:6-sulfatoxymelatonin; D004958:Estradiol; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D008550:Melatonin