title: Metabolic effects in rats of verapamil alone and in combination with captopril.
abstract: The metabolic effects of verapamil alone and in combination with captopril were investigated in rats. Animals received the maximum recommended doses for humans (per kg body weight per day) over a 2-week period. Verapamil had no significant effects on serum biochemistry, but caused a significant increase in serum potassium level and significant reductions in the rates of intestinal absorption of glucose and calcium. Verapamil/captopril had a number of significant effects on serum lipid profile (increased total cholesterol, increased HDL-cholesterol, and reduced LDL-cholesterol), and also provoked an increase in serum alanine amino-transferase activity and in serum glucose levels. The combination treatment caused a significant increase in serum chloride levels, but had no effect on intestinal absorption.
authors.affiliation: Departamento de Fisiologia, Facultad de Farmacia, Universidad de Santiago de Compostela, La Coruña, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Lopez
authors.forename: C
authors.initials: C
authors.lastname: Taboada
authors.forename: A
authors.initials: A
authors.lastname: San Miguel
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D001786:Blood Glucose; D002121:Calcium Channel Blockers; D008055:Lipids; D002216:Captopril; D014700:Verapamil; D000410:Alanine Transaminase; D005947:Glucose; D011188:Potassium; D002118:Calcium