title: Comparative chemical and biological studies of the alkaloidal content of Lygos species and varieties growing in Egypt.
abstract: Quinolizidine and dipiperidyl alkaloids profiles have been determined for various plant organs of Lygos raetam Forssk. L. raetam var. sarcocarpa and L. raetam var. bovei, using TLC, GC, GC-MS and HPLC techniques. Sixteen quinolizidine and dipiperidyl alkaloids were identified including baptofoline alkaloid which have not previously been reported in the genus Lygos. Biological evaluulation including hypoglycemic effect, anti-inflammatory activity, and some pharmacological studies of the different extracts as well as some of the isolated alkaloids were also performed. N-methylcytisine was proved to have a significant hypoglycemic effect on the induced diabetic mice and anti-inflammatory effect against the induced odema as well as a sedation effect on locomotor activity enhanced by methamphetamine.
authors.affiliation: Faculty of Pharmacy, Mansoura University, Egypt.
authors.forename: O B
authors.initials: OB
authors.lastname: Abdel Halim
authors.forename: H
authors.initials: H
authors.lastname: Abdel Fattah
authors.forename: A F
authors.initials: AF
authors.lastname: Halim
authors.forename: I
authors.initials: I
authors.lastname: Murakoshi
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D004534:Egypt; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D018517:Plant Roots; D018547:Plant Stems; D010946:Plants, Medicinal; D051381:Rats; D012639:Seeds; D014132:Trachea / Q000187:drug effects / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects / Q000502:physiology
chemical_list: D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose