Uncurved-DNA signals are important for translational positioning of nucleosomes.
We describe here a possible mechanism for non-random arrangement of nucleosomes along genomic DNA by short stretches of uncurved DNA. Available biochemical data on nucleosome positioning on different DNA sequences were analyzed. A strong correlation between location of nucleosome borders and location of uncurved sequences along DNA was observed. Tested sequences include satellites, 5S RNA genes and 5' regions of different genes.
Belikov
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S
W. A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Laboratory of Structure and Function of Chromatin, Moscow, Russia.
Kapranov
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A
Karpov
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V
D000818:Animals; D002522:Chlorocebus aethiops / Q000235:genetics; D004276:DNA, Satellite / Q000737:chemistry / Q000378:metabolism*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics; D006360:Heat-Shock Proteins / Q000235:genetics; D051379:Mice; D009707:Nucleosomes / Q000378:metabolism*; D014176:Protein Biosynthesis; D012341:RNA, Ribosomal, 5S; D051381:Rats; D012091:Repetitive Sequences, Nucleic Acid; D014982:Xenopus laevis / Q000235:genetics
D004276:DNA, Satellite; D029721:Drosophila Proteins; D006360:Heat-Shock Proteins; C087442:Hsp26 protein, Drosophila; D009707:Nucleosomes; D012341:RNA, Ribosomal, 5S