title: Multiple pancreatic masses associated with autoimmunity.
abstract: A 59-year-old woman was detected to have a high titer of serum gamma-globulin, positive antinuclear antibody and multiple pancreatic masses. In the course of 1 yr, Sjögren's syndrome developed, and her pancreatic masses spread diffusely and compressed the main pancreatic duct. A pancreatic biopsy by an exploration of the abdomen showed that many CD4 positive T-lymphocytes had infiltrated to the ducts and acinar cells expressing HLA-DR antigens. This suggested a diagnosis of autoimmune-related pancreatitis. She was treated with oral prednisolone, and a marked improvement of the above abnormal findings followed. In this report, a case of autoimmune-related multiple pancreatic masses associated with Sjögren's syndrome is presented, and a possible mechanism is discussed.
authors.affiliation: Department of Gastroenterology, Tenri Hospital, Nara, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohana
authors.forename: K
authors.initials: K
authors.lastname: Okazaki
authors.forename: K
authors.initials: K
authors.lastname: Hajiro
authors.forename: Y
authors.initials: Y
authors.lastname: Kobashi
mesh_terms: D000284:Administration, Oral; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000974:Antibodies, Antinuclear / Q000032:analysis; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy; D001706:Biopsy; D015153:Blotting, Western; D003937:Diagnosis, Differential; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage; D012859:Sjogren's Syndrome / Q000150:complications; D014057:Tomography, X-Ray Computed; D005719:gamma-Globulins / Q000032:analysis
chemical_list: D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D005719:gamma-Globulins; D011239:Prednisolone