title: [Clinical use of nitric oxide inhalation. Review of the literature and initial clinical experiences].
abstract: The authors review published data devoted to a new trend in intensive care of pulmonary hypertension: therapy of right ventricular heart failure and gas exchange disorders caused by impaired ventilation-perfusion relationship by inhalation of nitrogen oxide (NO). Mechanisms of NO effect, its metabolism, method of application and safety regulations, and doses and efficacy in various clinical situations (pulmonary hypertension in heart diseases, transplantations of the heart and lungs, respiratory distress syndrome, persistent pulmonary hypertension of the newborns) are analyzed. The first clinical experience gained by the authors demonstrated a favorable effect of NO therapy on the central hemodynamics in patients with acquired valvular defects and patients subjected to orthotopic transplantations of the heart. Approaches to research and pathogenetic validation of NO therapy are outlined.
authors.forename: I A
authors.initials: IA
authors.lastname: Kozlov
authors.forename: V N
authors.initials: VN
authors.lastname: Poptsov
mesh_terms: D000328:Adult; D000368:Aged; D003422:Critical Care; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000503:physiopathology; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000378:metabolism; D011659:Pulmonary Gas Exchange; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D012138:Respiratory Therapy; D014692:Ventilation-Perfusion Ratio; D018497:Ventricular Dysfunction, Right / Q000628:therapy*
chemical_list: D009569:Nitric Oxide