Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway.
DNA base excision repair (BER) is essential to preserving the integrity of the genome. Recent crystallographic studies of representatives from each enzyme class required for BER reveal clues to the structural basis of an entire DNA repair pathway.
Parikh
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Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Mol
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Tainer
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D000818:Animals; D001482:Base Composition; D018360:Crystallography, X-Ray; D004260:DNA Repair; D004798:Enzymes / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D005810:Multigene Family; D013329:Structure-Activity Relationship
D004798:Enzymes