Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: preliminary in vitro findings using a rat liver preparation.
Bourland
J A
JA
Martin
D K
DK
Mayersohn
M
M
D000818:Animals; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000493:pharmacokinetics*; D004951:Esterification; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008614:Meperidine / Q000493:pharmacokinetics*; D008774:Methylphenidate / Q000493:pharmacokinetics*; D009294:Narcotics / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000697:Central Nervous System Stimulants; D009294:Narcotics; D008774:Methylphenidate; D000431:Ethanol; D008614:Meperidine; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase