Differences in pre- and post-prandial plasma lipid profiles affect the extraction efficiency of a model highly lipophilic drug from beagle dog plasma.
Porter
C J
CJ
Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Parkville, Victoria, Australia. chris.porter@vcp.monash.edu.au
Caliph
S M
SM
Charman
W N
WN
D000818:Animals; D000962:Antimalarials / Q000097:blood* / Q000302:isolation & purification; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005215:Fasting / Q000097:blood; D008055:Lipids / Q000097:blood*; D008738:Methyl Ethers; D010616:Phenanthrenes / Q000097:blood* / Q000302:isolation & purification; D019518:Postprandial Period; D012997:Solvents; D014280:Triglycerides / Q000097:blood
D000962:Antimalarials; D008055:Lipids; D008738:Methyl Ethers; D010616:Phenanthrenes; D012997:Solvents; D014280:Triglycerides; C043243:methyl tert-butyl ether; C023768:halofantrine