A meta-analysis of chromosome 18 linkage data for bipolar illness.
We find a meta-data set (715 families, up to 1,124 sib pairs) for bipolar illness to have a strong signal in a 10 cM region around D18S40, and excess paternal sharing on the q arm near marker D18S64. We describe a method for meta-analysis of microsatellite marker data using affected sib-pair (ASP) methodology. Inherent difficulties in such analysis include heterogeneity of allele frequencies and protocol design, measurement errors in genotyping, and map construction. Using identity-by-descent (IBD) allele sharing as the dependent variable, a logistic regression to test for heterogeneity finds only mild heterogeneity, and a limited parent-of-origin effect.
Dorr
D A
DA
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Rice
J P
JP
Armstrong
C
C
Reich
T
T
Blehar
M
M
D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D009679:Nuclear Family