Structure of D-amino acid oxidase: new insights from an old enzyme.
D-amino acid oxidase is the prototype of flavin-dependent oxidases. The recent resolution of its 3D structure has provided an explanation for several of its properties and has led to a substantial revision of the mechanism of D-amino acid dehydrogenation, with significant implications for the general understanding of flavin-dependent catalysis.
Mattevi
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A
Dipartimento di Genetica e Microbiologia, Università di Pavia, Italy. mattevi@ipvgen.unipv.it
Vanoni
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MA
Curti
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B
D001665:Binding Sites; D002384:Catalysis; D003605:D-Amino-Acid Oxidase / Q000737:chemistry* / Q000378:metabolism; D019143:Evolution, Molecular; D005420:Flavoproteins / Q000737:chemistry; D006860:Hydrogen Bonding; D008958:Models, Molecular; D017434:Protein Structure, Tertiary
D005420:Flavoproteins; D003605:D-Amino-Acid Oxidase