title: A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells.
abstract: The mechanisms of action of immunological adjuvants were studied using a system in which the behavior of adoptively transferred CD4+ T-cell receptor transgenic T-cells could be directly monitored following antigen administration. These studies revealed that adjuvant-induced inflammatory cytokines promote immunity by enhancing the clonal expansion, persistence and differentiation of antigen-activated CD4+ T-cells.
authors.affiliation: Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Pape
authors.forename: M K
authors.initials: MK
authors.lastname: Jenkins
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000941:Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D016207:Cytokines