Herpes simplex virus type-2, cytomegalovirus and Epstein-Barr virus infection in acute non A to E hepatitis Thai patients.
A significant number of acute non A to E hepatitis cases are reported in Thailand every year, and the etiologies of these cases are unknown. Members of the herpesviridae family have been reported to cause either a self limited or fatal hepatitis in a small proportion of patients in other parts of the world. To determine whether herpesviruses may play a role in acute non A to E hepatitis, sera from 32 acute hepatitis patients without markers for acute hepatitis A to E virus infection were examined for IgM to herpesvirus type 2 (HSV-2), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) using commercially available assays. IgM to HSV-2 was detected in four sera, IgM to CMV was detected in one serum, and IgM to EBV was detected in one serum. All of the acute non A to E hepatitis patients recovered and none had underlying conditions associated with impaired immunity. These results suggest that herpesviruses should be considered in the differential diagnosis for Thai patients with hepatitis.
Maneerat
Y
Y
Faculty of Tropical Medicine, Siriraj Hospital, Bangkok, Thailand.
Wilairatana
P
P
Pongponratn
E
E
Puthavathana
P
P
Chaisri
U
U
Kurathong
S
S
Juthaputhi
A
A
Clayson
E T
ET
Snitbhan
R
R
Raengsakulrach
B
B
Vaughn
D W
DW
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D006558:Herpes Genitalis / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D018258:Herpesvirus 2, Human / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D013785:Thailand