title: Heparin-binding EGF-like growth factor.
abstract: HB-EGF is a heparin-binding member of the EGF family that was initially identified in the conditioned medium of human macrophages. Soluble mature HB-EGF is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells but not endothelial cells. HB-EGF activates two EGF receptor subtypes, HER1 and HER4 and binds to cell surface HSPG. The transmembrane form of HB-EGF is a juxtacrine growth and adhesion factor and is uniquely the receptor for diphtheria toxin. HB-EGF gene expression is highly regulated, for example by cytokines, growth factors, and transcription factors such as MyoD. HB-EGF has been implicated as a participant in a variety of normal physiological processes such as blastocyst implantation and wound healing, and in pathological processes such as tumor growth, SMC hyperplasia and atherosclerosis.
authors.affiliation: Department of Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: G
authors.initials: G
authors.lastname: Raab
authors.forename: M
authors.initials: M
authors.lastname: Klagsbrun
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001161:Arteriosclerosis; D001665:Binding Sites; D002448:Cell Adhesion; D002455:Cell Division; D002462:Cell Membrane / Q000502:physiology; D002874:Chromosome Mapping; D004815:Epidermal Growth Factor / Q000502:physiology*; D005786:Gene Expression Regulation; D005796:Genes; D019812:Heparan Sulfate Proteoglycans / Q000502:physiology; D006493:Heparin / Q000378:metabolism; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D006965:Hyperplasia; D036341:Intercellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D009135:Muscular Diseases / Q000473:pathology; D009369:Neoplasms / Q000503:physiopathology; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000502:physiology; D012098:Reproduction; D015398:Signal Transduction; D014945:Wound Healing
chemical_list: C587883:HBEGF protein, human; D019812:Heparan Sulfate Proteoglycans; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D006493:Heparin