title: Progressive supranuclear gaze palsy is in linkage disequilibrium with the tau and not the alpha-synuclein gene.
abstract: We studied two candidate genes, tau (tau) and alpha-synuclein (SNCA), for evidence of linkage disequilibrium on a group of unrelated individuals with progressive supranuclear palsy (PSP) and a group of age-matched control subjects. The tau alpha1 allele and the tau alpha1alpha1 genotype were overrepresented in individuals with PSP and the tau polymorphism was in linkage disequilibrium with the PSP disease locus when a recessive inheritance model was employed. We also report a lack of evidence to support linkage disequilibrium between PSP and the SNCA candidate Parkinson's disease gene on chromosome 4q21-q23.
authors.affiliation: Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Higgins
authors.forename: I
authors.initials: I
authors.lastname: Litvan
authors.forename: L T
authors.initials: LT
authors.lastname: Pho
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: L E
authors.initials: LE
authors.lastname: Nee
mesh_terms: D000368:Aged; D000483:Alleles; D002894:Chromosomes, Human, Pair 4; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D013494:Supranuclear Palsy, Progressive / Q000235:genetics*; D051843:Synucleins; D051844:alpha-Synuclein; D016875:tau Proteins / Q000235:genetics*
chemical_list: D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein; D016875:tau Proteins