[The immunosuppressive action of different fractions of Salmonella typhimurium lipopolysaccharide].
The suppressing activity of lipopolysaccharide (LPS) of the filtrates of genetically related S. typhimurium 415 and 415/307 cultures with respect to delayed hypersensitivity to nonbacterial antigen in mice was studied. In LPS of the virulent strain two immunosuppressing fractions differing in their molecular weight were detected by the method of gel filtration. One of them was detected in LPS of the genetically related nonplasmid clone of S. typhimurium 415/307. The possibility of the chemical inactivation and reactivation of the immunosuppressing properties of LPS was shown.
Borisova
E V
EV
Bondarenko
V M
VM
Molozhavaia
O S
OS
Borisov
V A
VA
D000818:Animals; D002850:Chromatography, Gel; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D010957:Plasmids / Q000276:immunology; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity; D014774:Virulence / Q000276:immunology
D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides