Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia.
Injury makes sensory neurons abnormally excitable and triggers coincident alterations in relative levels of different types of voltage-gated sodium channels that they express. We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral 'mirror-image' hyperalgesia described in nerve-injured humans and experimental animals.
Oaklander
A L
AL
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Belzberg
A J
AJ
D000818:Animals; D015536:Down-Regulation; D007839:Functional Laterality / Q000502:physiology*; D005727:Ganglia, Spinal / Q000378:metabolism*; D015640:Ion Channel Gating; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015222:Sodium Channels / Q000235:genetics*
D012333:RNA, Messenger; D015222:Sodium Channels