CCK-8S facilitates 5-HT release in the rat hypothalamus.
The effects of the neurotransmitter serotonin (5-HT) and the neuropeptide cholecystokinin (CCK) on food intake are well established. Based on pharmacological studies, an interactive model for 5-HT and CCK was proposed. The present microdialysis study was aimed to provide neurochemical evidence for a facilitatory effect of CCK-8S on 5-HT release in the lateral hypothalamus under in vivo conditions. The results indicate an increase of extracellular hypothalamic 5-HT both during food intake in previously food-deprived rats and also after systemic administration of 8 microg/kg and 40 microg/kg CCK-8s in food-deprived rats. The results show that peripherally administered CCK-8s induces central serotonergic effects, possibly related to feeding.
Voigt
J P
JP
Institute of Pharmacology and Toxicology, Humboldt University, Berlin, Germany.
Sohr
R
R
Fink
H
H
D000818:Animals; D000855:Anorexia / Q000139:chemically induced; D005247:Feeding Behavior / Q000502:physiology; D007026:Hypothalamic Area, Lateral / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents / Q000494:pharmacology*; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology
C090019:8-sulfocholecystokinin octapeptide; D018490:Serotonin Agents; D012701:Serotonin; D012844:Sincalide