title: Synthesis and anticonvulsant activity of new thiazolidinone and thioxoimidazolidinone derivatives derived from furochromones.
abstract: Various new thiazolidinone and thioxoimidazolidinone derivatives were synthesized starting from 4,9-dimethoxy-5 H-furo[3,2-g][1]benzopyran-5-on-7-carboxaldehyde. The anticonvulsant activity of the synthesized compounds was evaluated. Most of the compounds showed anticonvulsant activity equal or superior to phenobarbital.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Egypt.
authors.forename: F A
authors.initials: FA
authors.lastname: Ragab
authors.forename: N M
authors.initials: NM
authors.lastname: Eid
authors.forename: H A
authors.initials: HA
authors.lastname: el-Tawab
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003292:Convulsants; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007666:Khellin / Q000737:chemistry; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D010634:Phenobarbital / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D007093:Imidazoles; D013844:Thiazoles; D007666:Khellin; D010433:Pentylenetetrazole; D010634:Phenobarbital