title: The cyclin box fold: protein recognition in cell-cycle and transcription control.
abstract: Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.
authors.affiliation: Oxford Centre for Molecular Sciences, UK.
authors.forename: M E
authors.initials: ME
authors.lastname: Noble
authors.forename: J A
authors.initials: JA
authors.lastname: Endicott
authors.forename: N R
authors.initials: NR
authors.lastname: Brown
authors.forename: L N
authors.initials: LN
authors.lastname: Johnson
mesh_terms: D000595:Amino Acid Sequence; D002453:Cell Cycle; D019925:Cyclin A / Q000737:chemistry* / Q000378:metabolism; D056748:Cyclin H; D016213:Cyclins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016160:Retinoblastoma Protein / Q000737:chemistry* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D035581:Transcription Factor TFIIB; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D019925:Cyclin A; D056748:Cyclin H; D016213:Cyclins; D016160:Retinoblastoma Protein; D035581:Transcription Factor TFIIB; D014157:Transcription Factors