Chromatin remodeling regulated by steroid and nuclear receptors.
Coactivators and corepressors regulate transcription by controlling interactions between sequence-specific transcription factors, the basal transcriptional machinery and the chromatin environment. This review consider the access of nuclear and steroid receptors to chromatin, their use of corepressors and coactivators to modify chromatin structure and the implications for transcriptional control. The assembly of specific nucleoprotein architectures and targeted histone modification emerge as central controlling elements for gene expression.
Wolffe
A P
AP
Laboratory of Molecular Embryology, Nat'l Institute of Child Health and Human Development, Bethesda, MD 20892-5431, USA. awlme@helix.nih.gov
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology*
D002843:Chromatin; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid