Platelet-derived growth factor in human brain tumors.
This paper initially reviews ligand and receptor systems for the PDGF family and the signalling systems they use as well as their role in neural developments. It then describes the putative role of this family in astrocytoma, meningioma, and pituitary adenoma pathogenesis. Potential therapies with receptor antagonists or dominant negative mutants are discussed in the final sections.
Kirsch
M
M
Neurosurgical Laboratories, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Wilson
J C
JC
Black
P
P
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D010982:Platelet-Derived Growth Factor