Neurochemistry of cocaine withdrawal.
Neural circuits comprised of dopamine-containing and dopamine-receptive neurons are altered functionally after the repeated intermittent administration of cocaine and its withdrawal. The characterization of these neuroadaptive changes at various times after repeated exposure to cocaine is important because they may relate to addictive or withdrawal states associated with cocaine abuse. They also may suggest targets leading to the development of medications to treat one or more aspects of cocaine dependence.
Pilotte
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National Institute on Drug Abuse, Division of Basic Research, Rockville, MD 20857, USA. np22f@nih.gov
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D003042:Cocaine; D004298:Dopamine / Q000502:physiology; D006801:Humans; D009294:Narcotics; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D009294:Narcotics; D003042:Cocaine; D004298:Dopamine