Anthrax lethal toxin-induced mitogenic response of human T-cells.
Bacillus anthracis lethal toxin (PALF) stimulated the proliferation of human peripheral blood T-cells in vitro. Activation of T-lymphocytes by PALF required the presence of monocytes and did not result from a collaborative effect between T-cells and B-cells. PALF acted directly on monocytes and independently of T-cells. The monocytes contributed to the proliferation of T-cells by secretion of mediator(s). The mitogenic activity of the lethal toxin was dependent on its metalloprotease activity.
Guidi-Rontani
C
C
Laboratoire de Génétique Moléculaire des Toxines, CNRS URA1858, Institut Pasteur, Paris, France. rontani@pasteur.fr
Duflot
E
E
Mock
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M
D000942:Antigens, Bacterial; D001408:Bacillus anthracis / Q000502:physiology*; D001427:Bacterial Toxins / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008666:Metalloendopeptidases / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D015846:Monokines / Q000378:metabolism* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects*
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D008934:Mitogens; D015846:Monokines; C030325:anthrax toxin; D008666:Metalloendopeptidases