title: [Idiopathic and symptomatic hypereosinophilic syndromes (their comparative characteristics based on 14 cases)].
abstract: Clinical, hematological, cytogenetic and pathohistological findings in 14 patients with high eosinophilia allowed the authors to distinguish 2 groups of patients: with symptomatic (secondary) and idiopathic hypereosinophilic syndromes (6 and 8 patients, respectively). The latter was characterized by hepato- and splenomegaly, specific cardiac lesion (thromboplastic endocarditis), non-infectious fever, anemia and thrombocytopenia, marked hypercellularity of the bone marrow with inhibition of erythro- and megakaryocytopoiesis. Ph'-chromosome occurred in 2 out of 8 cases. Biopsy and autopsy histology in all cases of idiopathic hypereosinophilic syndrome were typical for myeloproliferative diseases. In symptomatic hypereosinophilic syndrome the above features were not registered.
authors.forename: N D
authors.initials: ND
authors.lastname: Khoroshko
authors.forename: R A
authors.initials: RA
authors.lastname: Mokeeva
authors.forename: A G
authors.initials: AG
authors.lastname: Turkina
authors.forename: E A
authors.initials: EA
authors.lastname: Semenova
authors.forename: A V
authors.initials: AV
authors.lastname: Pivnik
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged