Molecular organization of an individual Drosophila polytene chromomere: transcribed sequences in the 10A1-2 band.
Complete cloning of the DNA in the cytogenetic region 9F12-10A7 has allowed us to analyze the fine structure of an individual polytene chromomere in Drosophila melanogaster. In this report we identify the transcriptionally active fragments within the 10A1-2 band. At least 22 DNA fragments representing multiple distinct transcription units are active during embryogenesis, in third-instar larva or in isolated larval tissues. The transcribed fragments are significantly (at least sevenfold) more numerous than the three genetically defined complementation groups in the 10A1-2 band. One of the transcriptionally active zones detected encompasses a previously unsuspected homologue of the genes Delta and Serrate.
Kozlova
T
T
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russian Federation.
Zhimulev
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IF
Kafatos
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FC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002135:Calcium-Binding Proteins; D003001:Cloning, Molecular; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D000072099:Serrate-Jagged Proteins; D014158:Transcription, Genetic
D002135:Calcium-Binding Proteins; D029721:Drosophila Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; C000606278:Ser protein, Drosophila; D000072099:Serrate-Jagged Proteins; C064045:delta protein