title: The effect of extend of caval resection in the treatment of inferior vena cava leiomyosarcoma.
abstract: BACKGROUND
  A wide and complete surgical resection is the principle modality of therapy in the management of retroperitoneal sarcomas. It is current opinion that, also for inferior vena cava (IVC) leiomyosarcomas, an extended resection of either retroperitoneal tissue and vena cava should be performed. The aim of the study was to investigate the influence of the venous extent of resection on local recurrence and longterm outcome.
  
  
  METHODS
  Up to August 1994, 218 patients were enrolled into The International Registry of Inferior Vena Cava (IVC) Leiomyosarcomas. For the purpose of this study we considered 120 patients who underwent a radical resection of the IVC tumor (i.e. removal of all gross disease with microscopic tumor-free margins and no evidence of distant metastases). Resection included an IVC rim in 53 patients and an IVC segment in 67.
  
  
  RESULTS
  There were 3 (2.5%) early postoperative deaths and 7 (5.8%) major complications. Postoperative deep venous thrombosis of the lower limbs was diagnosed in 21 (17.5%) patients and was treated by anticoagulant therapy and/or elastic stocking without long-term sequelae. Overall, tumor recurrence was observed in 67 (57.3%) patients at a mean follow-up of 32 +/- 4 months. Seven, 13 and 4 patients who underwent caval wall resection and 9, 29 and 5 patients submitted to a caval segmental resection had either local recurrences, distant metastases or local and distant metastases (p = NS). Survival rates of the two groups were 55% and 37% at 5-year and 42% and 23% at 10-year, respectively (p = NS).
  
  
  CONCLUSIONS
  An extended venous resection in IVC leiomyosarcoma does not influence local recurrence rate nor long-term outcome.
authors.affiliation: 1st Department of Surgery, La Sapienza, University, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Mingoli
authors.forename: P
authors.initials: P
authors.lastname: Sapienza
authors.forename: A
authors.initials: A
authors.lastname: Cavallaro
authors.forename: L
authors.initials: L
authors.lastname: Di Marzo
authors.forename: C
authors.initials: C
authors.lastname: Burchi
authors.forename: D
authors.initials: D
authors.lastname: Giannarelli
authors.forename: R J
authors.initials: RJ
authors.lastname: Feldhaus
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D007890:Leiomyosarcoma / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D014682:Vena Cava, Inferior / Q000601:surgery*