title: A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension.
abstract: BACKGROUND
  A mutation in the gene for the angiotensin II type 1 (AT1) receptor (A1166C) has been reported to be associated with primary hypertension.
  
  
  OBJECTIVE
  To determine whether this observation could be confirmed with a different population sample.
  
  
  METHODS
  We examined 414 individuals with primary hypertension and 172 normotensive controls.
  
  
  METHODS
  The mutation in the gene for the AT1 receptor was detected using restriction polymerase chain reaction.
  
  
  CONCLUSIONS
  We detected no association of the AT1 receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the 1166C allele among hypertensive patients with a late age at diagnosis (> or = 50 years) was observed.
authors.affiliation: Department of Internal Medicine, University of Heidelberg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Beige
authors.forename: M
authors.initials: M
authors.lastname: Walla-Friedel
authors.forename: M C
authors.initials: MC
authors.lastname: Michel
authors.forename: A M
authors.initials: AM
authors.lastname: Sharma
authors.forename: E
authors.initials: E
authors.lastname: Ritz
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000502:physiology*; D011945:Receptors, Angiotensin / Q000235:genetics*; D012016:Reference Values
chemical_list: D011945:Receptors, Angiotensin