Metabolic effects in rats of verapamil alone and in combination with captopril.
The metabolic effects of verapamil alone and in combination with captopril were investigated in rats. Animals received the maximum recommended doses for humans (per kg body weight per day) over a 2-week period. Verapamil had no significant effects on serum biochemistry, but caused a significant increase in serum potassium level and significant reductions in the rates of intestinal absorption of glucose and calcium. Verapamil/captopril had a number of significant effects on serum lipid profile (increased total cholesterol, increased HDL-cholesterol, and reduced LDL-cholesterol), and also provoked an increase in serum alanine amino-transferase activity and in serum glucose levels. The combination treatment caused a significant increase in serum chloride levels, but had no effect on intestinal absorption.
Lopez
R
R
Departamento de Fisiologia, Facultad de Farmacia, Universidad de Santiago de Compostela, La Coruña, Spain.
Taboada
C
C
San Miguel
A
A
D000410:Alanine Transaminase / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D001786:Blood Glucose; D002121:Calcium Channel Blockers; D008055:Lipids; D002216:Captopril; D014700:Verapamil; D000410:Alanine Transaminase; D005947:Glucose; D011188:Potassium; D002118:Calcium