Detection of a t(8;21)(q22;q22) in a case of M5 acute monoblastic leukemia.
Although the translocation (8;21) is the single most common structural rearrangement reported in acute myeloblastic leukemia (AML), it is rarely seen in AML FAB type M5. We describe a case of a 51-year-old male with a diagnosis of acute monoblastic leukemia (AML M5b with hemophagocytic component) whose karyotype showed at (8;21)(q22;22). To our knowledge, this is the first report of this translocation in an AML M5b. The t(8;21) has been associated with a good prognosis, but our patient suffered a fast and fatal evolution.
Molero
M T
MT
Servicio de Hematología, Hospital Universitario Ntra. Sra. del Pino, Las Palmas de Gran Canaria, Spain.
Gómez Casares
M T
MT
Valencia
J M
JM
Bueno
J L
JL
Suárez
A
A
Ruano
A
A
Molinés
A
A
Campo
C
C
Malcorra
J J
JJ
D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic