title: Neuropsychological dysfunction and clinical outcome in psychiatric disorders: a two-year follow-up study.
abstract: The presence of neuropsychological disturbances in schizophrenia and mood disorders raises the question that cognitive impairments might contribute to poor outcome. This report examines changes in neuropsychological performance from hospitalization to a 2-year follow-up evaluation in relation to psychosocial outcome. Findings indicated that unfavorable clinical outcome is associated with marginal changes in neuropsychological performance, whereas good outcome status is associated with neuropsychological improvement. Neuropsychological improvement may thus require a stable period of favorable psychosocial recovery, in schizophrenia and schizoaffective disorder, as well as major mood disorder syndromes.
authors.affiliation: Department of Psychology, Long Island University, Brookville, New York 11548, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Silverstein
authors.forename: M
authors.initials: M
authors.lastname: Harrow
authors.forename: G
authors.initials: G
authors.lastname: Mavrolefteros
authors.forename: D
authors.initials: D
authors.lastname: Close
mesh_terms: D000328:Adult; D017668:Age of Onset; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000523:psychology; D019964:Mood Disorders / Q000175:diagnosis / Q000523:psychology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D011618:Psychotic Disorders / Q000175:diagnosis / Q000523:psychology; D014888:Wechsler Scales