[Evaluation of hyperkinetic cardiac arrhythmia in chronic obstructive bronchopneumopathy].
Patients with chronic obstructive pulmonary disease (COPD), especially during acute exacerbations of their disease, show a greater incidence of cardiac arrhythmias than healthy subjects of the same age. The type of arrhythmias found may be supraventricular (premature atrial beats, paroxysmal supraventricular tachycardia, multifocal atrial tachycardia, atrial flutter, atrial fibrillation) or ventricular (premature ventricular beats, sustained ventricular tachycardia, torsades de pointes, ventricular fibrillation) that may lead to sudden cardiac death. The pathogenesis of arrhythmias is complex and many factors may be involved such as hypoxemia, hypercapnia, respiratory acidosis, metabolic and respiratory alchalosis, hypokalemia, concomitant ischemic heart disease, chronic cor pulmonale, left ventricular diastolic dysfunction. Remarkable attention has been drawn to the possible arrhythmogenic effect of drugs such as theophylline, beta-adrenergic stimulants and digitalis which are commonly used in the therapy of COPD. Both of the main classes of bronchodilators (methylxanthynes and beta-adrenergic agonists), even when used together, apparently do not increase the incidence of dangerous cardiac arrhythmias. However, these drugs should be used with caution in the elderly, in patients with preexisting cardiac arrhythmias, with heart disease or with reduced hepatic function. In these cases Holter monitoring, repeated measurements of plasma drugs concentration and prompt hospitalization of high risk patients in Intensive Care Unit may be needed.
Conte
G
G
Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi, Padova.
Lauro
S
S
Lazzarin
M
M
Rigon
N
N
Perrone
A
A
D000318:Adrenergic beta-Agonists / Q000009:adverse effects / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D001996:Bronchopneumonia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004071:Digitalis Glycosides / Q000009:adverse effects / Q000627:therapeutic use; D015716:Electrocardiography, Ambulatory; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D013614:Tachycardia, Paroxysmal / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D013806:Theophylline / Q000009:adverse effects / Q000627:therapeutic use
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D004071:Digitalis Glycosides; D013806:Theophylline