[Oral tolerance in the treatment of rheumatoid arthritis and other autoimmune diseases].
Oral administration of antigen has been recognized as a form of inducing antigen-specific unresponsiveness. Studies in animal models of autoimmune diseases have shown the effectiveness of such an approach. Recently, three clinical trials have suggested that oral tolerance can be useful in human disease. In this review, we address the mechanisms underlying this system and the role of oral tolerance in the treatment of human autoimmune disease.
Torigoe
D Y
DY
Disciplina de Reumatologia, Faculdade de Medicina, Universidade de São Paulo.
Yoshinari
N H
NH
D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000008:administration & dosage* / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy*; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance
D000941:Antigens