title: Molecular analysis of foot-and-mouth disease type O viruses isolated in Saudi Arabia between 1983 and 1995.
abstract: Partial nucleotide sequence of the capsid polypeptide coding gene 1D (VP1) was determined for 68 serotype O foot-and-mouth disease viruses isolated between 1983 and 1995 from outbreaks occurring in Saudi Arabia. The sequences were compared with previously published sequences: 14 viruses of Middle Eastern origin (isolated between 1987 and 1991); and with four vaccine virus strain sequences, three originating from the Middle East (O1/Turkey/Manisa/69, O1/Sharquia/Egypt/72 and O1/Israel/2/85) and one from Europe (O1/BFS 1860/UK/67). The virus isolates from Saudi Arabia and the Middle East vaccine virus strains formed a related genetic group distinct from the European O1 virus. Within this large group 12 distinct genetic sublineages were observed.
authors.affiliation: OIE/FAO World Reference Laboratory for Foot-and-Mouth Disease, Institute for Animal Health, Pirbright Laboratory, Surrey, UK.
authors.forename: A R
authors.initials: AR
authors.lastname: Samuel
authors.forename: N J
authors.initials: NJ
authors.lastname: Knowles
authors.forename: R P
authors.initials: RP
authors.lastname: Kitching
authors.forename: S M
authors.initials: SM
authors.lastname: Hafez
mesh_terms: D000818:Animals; D005537:Aphthovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D002417:Cattle; D004196:Disease Outbreaks / Q000662:veterinary*; D005536:Foot-and-Mouth Disease / Q000453:epidemiology / Q000821:virology*; D008877:Middle East / Q000453:epidemiology; D012529:Saudi Arabia / Q000453:epidemiology; D017422:Sequence Analysis, DNA; D012756:Sheep