title: Hematometra after radiotherapy for cervical carcinoma.
abstract: The development of a hematometra after radiotherapy for cervical carcinoma is often related to recurrent disease. We present two cases in which a hematometra developed during the use of estrogen replacement therapy. This development was related to regained endometrial activity in combination with fibrosis and obliteration of the upper vagina and/or cervix. In one patient a dilatation and curettage could be performed; in the other a hysterectomy was necessary in order to exclude recurrent disease. These two cases show once more that endometrium can regain its proliferative activity after radiotherapy for cervical cancer. Estrogen replacement therapy in these patients should include the use of a progestagen agent in order to avoid continuous unopposed endometrial stimulation. In the absence of progesterone withdrawal bleeding the uterine cavity should be routinely examined for the development of a hematometra.
authors.affiliation: Bosch Medical Center, Department of Obstetrics and Gynecology, ME's-Hertogenbosch, The Netherlands.
authors.forename: C B
authors.initials: CB
authors.lastname: Vernooij
authors.forename: R F
authors.initials: RF
authors.lastname: Kruitwagen
authors.forename: P
authors.initials: P
authors.lastname: Rodrigus
authors.forename: H C
authors.initials: HC
authors.lastname: Kock
authors.forename: H W
authors.initials: HW
authors.lastname: Feyen
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D005260:Female; D006409:Hematometra / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*