title: Development of Graves' disease after surgical treatment for thyroid nodules: report of four cases.
abstract: We report herein rare cases who developed hyperthyroid Graves' disease after surgical treatments for thyroid nodules. We have seen only 4 such cases in the course of 1680 consecutive cases (0.24%) of thyroidectomies in which partial thyroidectomy was carried out from 1966 to 1993. It is of interest that because 2 of these three cases (67%) were associated with positive TGHA and/or MCHA at the time of surgery, the presence of autoimmune thyroiditis may predispose to Graves' disease, but surgical treatment of the thyroid glands may not be related to the development of Graves' disease, because the hyperthyroid symptoms appeared 2 to 27 years (mean: 12 years) after the surgery.
authors.affiliation: Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kasuga
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Fujimori
authors.forename: K
authors.initials: K
authors.lastname: Shingu
authors.forename: Y
authors.initials: Y
authors.lastname: Hama
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: J
authors.initials: J
authors.lastname: Amano
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006111:Graves Disease / Q000209:etiology*; D006801:Humans; D013960:Thyroid Function Tests; D013964:Thyroid Neoplasms / Q000150:complications / Q000601:surgery*; D016606:Thyroid Nodule / Q000150:complications / Q000601:surgery*; D013965:Thyroidectomy