title: Comparative effects of malaria and malnutrition on plasma concentrations of antioxidant micronutrients in children.
abstract: The comparative effects of malaria and malnutrition on plasma antioxidant vitamins were studied in 65 children aged 8-96 months. Forty-six (71%) of them had malaria; nineteen (29%) served as controls. Patients and controls were further subdivided into two groups depending on whether they were malnourished or well nourished, as defined by weight-for-age Z score (WAZ) +/- -2. Plasma levels of alpha-tocopherol, beta-carotene and retinol were measured. Results indicate that malaria was associated with levels of antioxidants lower than in the controls. Two-way analysis of variance shows that for all three plasma micronutrients concentrations were lower in those children infected with malaria but were not influenced by malnutrition. There were an equal number of malnourished children in both malaria and non-malaria groups; nevertheless, WAZ tended to be lower in those with malaria (p = 0.056), although this did not quite reach significance. It is concluded that in areas where malaria and malnutrition co-exist, malaria alone exerts a greater influence on plasma antioxidants than does malnutrition.
authors.affiliation: Department of Community Health, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria. dadeleka@oauife.edu.ng
authors.forename: D A
authors.initials: DA
authors.lastname: Adelekan
authors.forename: O O
authors.initials: OO
authors.lastname: Adeodu
authors.forename: D I
authors.initials: DI
authors.lastname: Thurnham
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008288:Malaria / Q000097:blood* / Q000150:complications; D009549:Nigeria; D009748:Nutrition Disorders / Q000097:blood* / Q000150:complications; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E