Possible role of transforming growth factor-beta in relapsing-remitting multiple sclerosis.
Cerebrospinal fluid (CSF) and serum levels of transforming growth factor (TGF)-beta and soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated in ten patients with definite multiple sclerosis (MS) of the relapsing-remitting type. CSF TGF-beta levels of MS patients in remission were significantly (p < 0.01) higher than of MS patients in active phase, and there was a significant inverse correlation (p < 0.05) between TGF-beta and slCAM-1 levels in the CSF of patients in both remitting and relapsing type. This is consistent with a possible down-regulation of TGF-beta on ICAM-1 expression and suggests a possible synthesis in the central nervous system of TGF-beta.
Carrieri
P B
PB
Department of Neurological Sciences, University of Naples Federico II, Italy.
Provitera
V
V
Bruno
R
R
Perrella
M
M
Tartaglia
G
G
Busto
A
A
Perrella
O
O
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D012008:Recurrence; D016212:Transforming Growth Factor beta / Q000097:blood / Q000134:cerebrospinal fluid*
D016212:Transforming Growth Factor beta; D018799:Intercellular Adhesion Molecule-1