title: Intrahippocampal GMP administration improves inhibitory avoidance performance through GABAergic and glutamatergic mechanisms in rats.
abstract: Guanidino compounds play specific physiological and pathological roles in the central nervous system. We investigated the effect of an intrahippocampal infusion of GMP (a guanidino compound) administered immediately post-training on the inhibitory avoidance learning paradigm in rats. Bilateral intrahippocampal micro-injection of GMP (0-30 nmol) caused a dose-dependent increase in test step-down latencies which was completely reversed by intrahippocampal co-administration of muscimol or baclofen (GABA agonists) or preadministration (15 min pre-training, i.p.) of MK-801 (an NMDA antagonist). These results provide evidence for a participation of GABA and NMDA receptors in the GMP-induced increase in the test step-down latencies.
authors.affiliation: Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, RS, Brasil.
authors.forename: M A
authors.initials: MA
authors.lastname: Rubin
authors.forename: A
authors.initials: A
authors.lastname: Jurach
authors.forename: G R
authors.initials: GR
authors.lastname: Zanolla
authors.forename: R L
authors.initials: RL
authors.lastname: Boemo
authors.forename: D O
authors.initials: DO
authors.lastname: Souza
authors.forename: C F
authors.initials: CF
authors.lastname: de Mello
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001418:Baclofen / Q000494:pharmacology*; D006152:Cyclic GMP / Q000008:administration & dosage / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D007839:Functional Laterality; D018755:GABA Agonists / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008845:Microinjections; D009118:Muscimol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D018755:GABA Agonists; D016194:Receptors, N-Methyl-D-Aspartate; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D016291:Dizocilpine Maleate; D006152:Cyclic GMP; D001418:Baclofen