Determination of hydroxylated polychlorinated biphenyls by ion trap gas chromatography-tandem mass spectrometry.
Hydroxylated polychlorinated biphenyls also known as biphenylols, are suspected estrogen mimics found in the environment. Various derivatization schemes were evaluated and a gas chromatography-ion trap mass spectrometry method was developed for the trifluoroacetyl derivative using MS-MS techniques for the analysis of eleven biphenylols. A time-segmented chromatographic method was developed using the respective MS-MS parameters to analyze all the eleven biphenylols in a single chromatographic run. Isomers were differentiated based on the MS-MS data of the trofluoroacetyl-biphenylol derivatives. The method was applied to detect 40 pg on-column of these compounds in a spiked egg sample which simulates a real world sample.
Abraham
V M
VM
Department of Chemistry, Mississippi State University, Mississippi State 39762, USA.
Lynn
B C
BC
D004531:Eggs / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006900:Hydroxylation; D008970:Molecular Weight; D011078:Polychlorinated Biphenyls / Q000032:analysis*; D014297:Trimethylsilyl Compounds / Q000032:analysis
D014297:Trimethylsilyl Compounds; D011078:Polychlorinated Biphenyls