Stem cell transcription factors.
The individual properties of hematopoietic stem cells, including self-renewal, maintenance of pluripotency, and asymmetric cell division, must depend at some level on the functions of specific transcription factors. Recently, valuable insights into stem cell transcription factor function have emerged from targeted gene disruption (knockout) studies in mice. Absence of transcription factors belonging to diverse protein families results in interference with expansion and differentiation of either the stem cell itself or of primitive multipotential progenitors. The findings from these and complementary experiments provide a framework for examining the transcription control of the earliest cellular events in hematopoiesis.
Shivdasani
R A
RA
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D050989:GATA2 Transcription Factor; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D006801:Humans; D060588:LIM Domain Proteins; D008667:Metalloproteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors
D048868:Adaptor Proteins, Signal Transducing; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D050989:GATA2 Transcription Factor; D060588:LIM Domain Proteins; D008667:Metalloproteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors; C494711:GATA2 protein, human; C085117:LMO2 protein, human; C067143:TAL1 protein, human