Influence of minor increases in plasma catecholamines on natural killer cell activity.
This study was designed to test the hypothesis that the modulations of the human immune system in relation to in vivo whole body hyperthermia may be ascribed to elevations in the plasma epinephrine and norepinephrine concentrations. In a single-blind, controlled, cross-over study, 8 healthy volunteers were selectively infused norepinephrine and epinephrine, respectively, for 1 h, in order to obtain twofold increases in the plasma concentrations of these hormones, thereby mimicking the increases seen during in vivo whole body hyperthermia. Epinephrine infusion increased baseline, interleukin-2 and interferon-alpha stimulated natural killer cell activity, and the percentage and concentration of cluster designation (CD)16+ cells, whereas the neutrophil and lymphocyte count or the CD3+, CD4+, CD8+, CD19+ and CD14+ cell subtypes were not influenced. Norepinephrine infusion did not cause any changes in these variables. It is concluded that epinephrine, but not norepinephrine, may be responsible for the hyperthermia-induced effects on natural killer cells.
Kappel
M
M
Copenhagen Muscle Research Centre, Department of Infectious Diseases, Rigshospitalet, National University Hospital, Denmark. kappel@rh.dk
Poulsen
T D
TD
Galbo
H
H
Pedersen
B K
BK
D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology; D018592:Cross-Over Studies; D004837:Epinephrine / Q000008:administration & dosage / Q000097:blood*; D005334:Fever / Q000097:blood / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D009638:Norepinephrine / Q000008:administration & dosage / Q000097:blood*; D017452:Receptors, IgG / Q000097:blood / Q000187:drug effects; D016037:Single-Blind Method; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
D000970:Antineoplastic Agents; D016898:Interferon-alpha; D007376:Interleukin-2; D017452:Receptors, IgG; D014662:Vasoconstrictor Agents; D009638:Norepinephrine; D004837:Epinephrine