[The pathogenetic importance of Yersinia pseudotuberculosis lipopolysaccharide].
The immunogenic and immunomodulating properties of Y. pseudotuberculosis lipopolysaccharide (LPS) with a view to the evaluation of its role in the pathogenesis of Y. pseudotuberculosis infection were studied. The study revealed the importance of LPS as immunogen, the degree of its immunogenicity for laboratory animals and interstrain differences in the response of mice to LPS in the course of immune processes. The role of the immunomodulating activity of LPS with respect to humoral and cellular immunity factors was shown in pathogenesis. Special attention was paid to the stimulating action of LPS on the phagocytic function of macrophages. The hypothetic scheme of the participation of LPS in the pathogenesis of Y. pseudotuberculosis experimental infection was presented.
Kuznetsova
T A
TA
Besednova
N N
NN
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000921:Antibody-Producing Cells / Q000276:immunology; D006168:Guinea Pigs; D007114:Immunization; D007928:Lethal Dose 50; D008070:Lipopolysaccharides / Q000276:immunology / Q000633:toxicity*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009895:Opsonin Proteins / Q000097:blood; D011817:Rabbits; D013154:Spleen / Q000276:immunology; D015011:Yersinia pseudotuberculosis / Q000276:immunology / Q000472:pathogenicity*; D015012:Yersinia pseudotuberculosis Infections / Q000209:etiology / Q000276:immunology
D000907:Antibodies, Bacterial; D008070:Lipopolysaccharides; D009895:Opsonin Proteins