title: Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation.
abstract: To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.
authors.affiliation: Uludağ University Faculty of Medicine, Department of Biochemistry, Bursa, Turkey.
authors.forename: P
authors.initials: P
authors.lastname: Tuncel
authors.forename: E S
authors.initials: ES
authors.lastname: Gür
authors.forename: E
authors.initials: E
authors.lastname: Kaya
authors.forename: R
authors.initials: R
authors.lastname: Ozbek
authors.forename: E
authors.initials: E
authors.lastname: Oztürk
authors.forename: R
authors.initials: R
authors.lastname: Tokyay
mesh_terms: D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D010538:Peritonitis / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D002927:Cimetidine