title: [Fast neutrons in the treatment of malignant neoplasms].
abstract: More than 250 patients, mainly with locally advanced tumors of the head, neck and breast were treated with a I MeV beam of fast neutrons emitted from a BR-10 reactor. The fast neutron contribution to the total dose of the radical component of complex gamma-neutron therapy was 20-40%. Said modality was shown to improve the results of treatment for laryngeal and breast tumors. The 5-year actuarial survival following complex gamma-neutron therapy for laryngeal cancer was 89.25, while in controls--65.2% (p < 0.005). The 5-year actuarial overall survival in breast cancer patients treated with fast neutrons was 66.5%: gamma-neutron therapy alone--46.0% (p < 0.05).
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Mardynskiĭ
authors.forename: I A
authors.initials: IA
authors.lastname: Gulidov
authors.forename: A S
authors.initials: AS
authors.lastname: Sysoev
authors.forename: V G
authors.initials: VG
authors.lastname: Andreev
authors.forename: V N
authors.initials: VN
authors.lastname: Medvedev
authors.forename: V M
authors.initials: VM
authors.lastname: Zagrebin
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005214:Fast Neutrons; D005260:Female; D005720:Gamma Rays; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D016019:Survival Analysis; D016896:Treatment Outcome