title: Haemoglobin D-Ouled Rabah among the Mozabites: a relevant variant to trace the origin of Berber-speaking populations.
abstract: We have studied haemoglobin (Hb) variants and blood groups (ABO, RH, and Kell) in 598 children from the Berber population of the Mzab. Hb D-Ouled Rabah, considered as a private marker of the Kel Kummer Tuaregs, and Hb C were found at the same gene frequency (0.015). Haplotype analysis suggests a single origin to the Hb D mutation. Genetic distances calculated from the blood group data cluster Mozabites and Tuaregs with the other Berber-speaking groups, Arabic-speaking populations being more distant. But, we found no specific relationship between Mozabites and Kel Kummers. Tuaregs in general exhibit features that tend to differentiate them from other Berber-speaking groups. Hb D-Ouled Rabah may be specific of Berber-speaking populations.
authors.affiliation: INSERM U458, Hôpital Robert-Debré, Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Merghoub
authors.forename: A
authors.initials: A
authors.lastname: Sanchez-Mazas
authors.forename: R
authors.initials: R
authors.lastname: Tamouza
authors.forename: C Y
authors.initials: CY
authors.lastname: Lu
authors.forename: K
authors.initials: K
authors.lastname: Bouzid
authors.forename: F Z
authors.initials: FZ
authors.lastname: Ardjoun
authors.forename: D
authors.initials: D
authors.lastname: Labie
authors.forename: C
authors.initials: C
authors.lastname: Lapouméroulie
authors.forename: J
authors.initials: J
authors.lastname: Elion
mesh_terms: D000462:Algeria; D001789:Blood Group Antigens / Q000235:genetics*; D004252:DNA Mutational Analysis; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes; D006444:Hemoglobin C / Q000235:genetics; D006454:Hemoglobins / Q000032:analysis / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D001789:Blood Group Antigens; D005819:Genetic Markers; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; C032001:hemoglobin D; D006444:Hemoglobin C