title: Possible role of transforming growth factor-beta in relapsing-remitting multiple sclerosis.
abstract: Cerebrospinal fluid (CSF) and serum levels of transforming growth factor (TGF)-beta and soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated in ten patients with definite multiple sclerosis (MS) of the relapsing-remitting type. CSF TGF-beta levels of MS patients in remission were significantly (p < 0.01) higher than of MS patients in active phase, and there was a significant inverse correlation (p < 0.05) between TGF-beta and slCAM-1 levels in the CSF of patients in both remitting and relapsing type. This is consistent with a possible down-regulation of TGF-beta on ICAM-1 expression and suggests a possible synthesis in the central nervous system of TGF-beta.
authors.affiliation: Department of Neurological Sciences, University of Naples Federico II, Italy.
authors.forename: P B
authors.initials: PB
authors.lastname: Carrieri
authors.forename: V
authors.initials: V
authors.lastname: Provitera
authors.forename: R
authors.initials: R
authors.lastname: Bruno
authors.forename: M
authors.initials: M
authors.lastname: Perrella
authors.forename: G
authors.initials: G
authors.lastname: Tartaglia
authors.forename: A
authors.initials: A
authors.lastname: Busto
authors.forename: O
authors.initials: O
authors.lastname: Perrella
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D012008:Recurrence; D016212:Transforming Growth Factor beta / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D016212:Transforming Growth Factor beta; D018799:Intercellular Adhesion Molecule-1