title: Guanine nucleotides are present in human CSF.
abstract: Several studies have shown that experimentally added guanine nucleotides (GN) may extracellularly modulate the glutamatergic system. However, there is no previous report of the extracellular occurrence of GN in the CNS. This study used HPLC to investigate the presence of GN in cerebrospinal fluid (CSF) samples of 26 patients. We demonstrated the extracellular presence of GN in the CNS. In human CSF, GMP was detected in a remarkably high concentration (236.20 microM). This evidence stimulates further investigation of extracellular GN modulation of neurotransmission, physiological mechanisms of action(s), and therapeutic potential(s) in the CNS.
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Regner
authors.forename: R E
authors.initials: RE
authors.lastname: Crestana
authors.forename: J P
authors.initials: JP
authors.lastname: Silveira F
authors.forename: G
authors.initials: G
authors.lastname: Friedman
authors.forename: I
authors.initials: I
authors.lastname: Chemale
authors.forename: D
authors.initials: D
authors.lastname: Souza
mesh_terms: D000227:Adenine Nucleotides / Q000134:cerebrospinal fluid*; D000328:Adult; D001416:Back Pain / Q000134:cerebrospinal fluid*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006150:Guanine Nucleotides / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009192:Myelography
chemical_list: D000227:Adenine Nucleotides; D006150:Guanine Nucleotides