Clear cell sarcoma of the ileum: the crucial role of cytogenetics for the diagnosis.
We report a case of clear cell sarcoma that arose in the ileum and metastasized to the liver. The tumor cells did not contain melanin or glycogen; expressed S-100 protein, but not HMB45; and contained possible atypical melanosomes when examined by electron microscopy. They carried a clonal chromosomal rearrangement: 50,XY,t(2;7)(q37;q22),+8,+8,+9,+11, t(12;22)(q13;q12). The diagnosis was greatly facilitated by the cytogenetic analysis. The translocation t(12;22)(q13;q12-13) has been reported as specific for clear cell sarcomas.
Donner
L R
LR
Department of Pathology, Scott & White Clinic, Texas A & M University Health Science Center, College of Medicine, Temple 76508, USA.
Trompler
R A
RA
Dobin
S
S
D000328:Adult; D014408:Biomarkers, Tumor; D002869:Chromosome Aberrations; D003582:Cytogenetics; D006801:Humans; D007078:Ileal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D008297:Male; D015388:Organelles / Q000648:ultrastructure; D009418:S100 Proteins / Q000378:metabolism; D018227:Sarcoma, Clear Cell / Q000235:genetics / Q000378:metabolism / Q000556:secondary*
D014408:Biomarkers, Tumor; D009418:S100 Proteins