title: Second primitive malignant tumour in patients with gynaecological cancer.
abstract: OBJECTIVE
  The purpose of this study was to characterise the occurrence of multiple primitive gynaecological malignant neoplasias, restricted to the genital tract and breast or associated with other organs, and to detect which types of association are most frequent concerning location, histology and staging.
  
  
  METHODS
  The records of patients with gynaecological cancer at the Portuguese Institute of Oncology--Lisbon Centre, between 1986 and 1993 were used in this study.
  
  
  RESULTS
  Of the 10,746 women with gynaecological cancer, 91 (0.8%) were found to have a second primitive malignant neoplasia. Of these neoplasias, 64% (58 cases) were also located at a gynaecological site. The most frequent associations were endometrium/breast (13 cases), bilateral breast (12 cases) and ovary/endometrium (11 cases). The majority of primitive multiple gynaecological tumours were synchronous. Regarding gynaecological cancer and non-gynaecological cancer, in 28 cases (31%), the most common non-gynaecological location was the colon/rectum. Five patients had triple tumours.
  
  
  CONCLUSIONS
  Although these situations are relatively rare the possibility of multiple primitive cancers should be considered with the presence of malignant tumours in two or more organs. This distinction between multiple primitive or metastatic cancers could be important for treatment as well as prognosis.
authors.affiliation: Obstetrics and Gynaecology Department, Garcia de Orta Hospital, Almada, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Nunes
authors.forename: J
authors.initials: J
authors.lastname: Saraiva
authors.forename: A
authors.initials: A
authors.lastname: Francisca
authors.forename: M J
authors.initials: MJ
authors.lastname: Botica
authors.forename: M do C
authors.initials: Mdo C
authors.lastname: Diniz
authors.forename: I
authors.initials: I
authors.lastname: Cabral
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000473:pathology*