title: T1-weighted three-dimensional magnetization transfer MR of the brain: improved lesion contrast enhancement.
abstract: OBJECTIVE
  We developed and evaluated clinically T1-weighted three-dimensional gradient-echo magnetization transfer (MT) sequences for contrast-enhanced MR imaging of the brain.
  
  
  METHODS
  A short-repetition-time, radio frequency-spoiled, 3-D sequence was developed with a 10-millisecond MT pulse at high MT power and narrow MT pulse-frequency offset, and the enhancing lesion-to-normal white matter background (L/B) and the contrast-to-noise (C/N) ratios on these images were compared with those on T1-weighted spin-echo images and on non-MT 3-D gradient-echo images in a prospective study of 45 patients with 62 enhancing lesions. In the 24 patients who had intracranial metastatic disease, the number of lesions was counted and compared on the three types of images.
  
  
  RESULTS
  The MT ratio of normal callosal white matter was 55% on the MT 3-D gradient-echo sequences. The L/B and C/N on the MT 3-D gradient-echo images were more than double those on the 3-D gradient-echo images, and were significantly greater than those on the T1-weighted spin-echo images. In patients with metastatic disease, the MT 3-D gradient-echo images showed significantly more lesions than did the T1-weighted spin-echo or 3-D gradient-echo images.
  
  
  CONCLUSIONS
  MT 3-D gradient-echo MR imaging improves the contrast between enhancing lesion and background white matter over that obtained with conventional T1-weighted 3-D gradient-echo and spin-echo imaging. MT 3-D gradient-echo imaging provides practical sampling, image coverage, and spatial resolution, attributes that may be advantageous over MT T1-weighted spin-echo techniques.
authors.affiliation: Department of Radiology, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Finelli
authors.forename: G C
authors.initials: GC
authors.lastname: Hurst
authors.forename: R P
authors.initials: RP
authors.lastname: Gullapalli
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008579:Meningioma / Q000175:diagnosis; D009442:Neurilemmoma / Q000175:diagnosis; D011446:Prospective Studies