title: [Proximal myotonic myopathy (PROMM). Clinical variability within a family].
abstract: Proximal myotonic myopathy (PROMM) is a newly described autosomal dominant inherited disorder characterized by predominant proximal weakness of the legs, mild clinical myotonia or myotonia on electromyograms (EMG), cataracts and slight elevation of liver enzymes. The trinucleotide (cytosine, thymine, and guanine) repeat size of the myotonic dystrophy (DM) gene is normal. Magnetic resonance imaging of the brain may reveal a peculiar pattern of white matter abnormalities. We describe seven patients in a new family with PROMM. The only symptoms may be subclinical myotonic changes in the EMG or cataracts, but symptoms may also include severe proximal weakness of the legs and painful paraesthesia. PROMM is an important differential diagnosis of myotonic dystrophy; and because of the proximal weakness it is also a differential diagnosis of other muscle diseases such as limb girdle dystrophy, metabolic and endocrine myopathies, and myositis. Because of the variability of the symptoms, for the definite diagnosis of PROMM it may require the examination of other family members.
authors.affiliation: Klinik und Poliklinik für Neurologie der Martin-Luther-Universität Halle-Wittenberg.
authors.forename: K
authors.initials: K
authors.lastname: Eger
authors.forename: W J
authors.initials: WJ
authors.lastname: Schulte-Mattler
authors.forename: S
authors.initials: S
authors.lastname: Zierz
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D002386:Cataract / Q000235:genetics; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D003937:Diagnosis, Differential; D004576:Electromyography; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009222:Myotonia / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D014057:Tomography, X-Ray Computed