Nonsteroidal-induced benign strictures of the colon: a case report and review of the literature.
Colonic strictures are a rare complication reported to result from chronic use of sustained release formulations of indomethacin and diclofenac. Such strictures often present with associated mucosal ulceration and are thought to result from nonsteroidal antiinflammatory drug-induced alterations in enterocyte homeostasis. Strictures generally occur in the cecum, ascending, and proximal transverse colon with symptoms of occult blood loss, obstruction, changes in bowel habits, and rarely, perforation. The first reported case of a 69-year-old woman who developed recurrent colonic strictures with inflammatory changes and mucosal ulceration while taking Lodine (etodolac) is presented. A brief review of the relevant literature and suggested preventative therapies are discussed.
Eis
M J
MJ
University of Cincinnati College of Medicine, and Department of Surgery, Good Samaritan Hospital, Ohio 45220, USA.
Watkins
B M
BM
Philip
A
A
Welling
R E
RE
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003108:Colonic Diseases / Q000139:chemically induced* / Q000175:diagnosis; D003113:Colonoscopy; D003251:Constriction, Pathologic / Q000139:chemically induced; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D017308:Etodolac / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D017308:Etodolac