title: Technetium 94m-labeled methoxyisobutyl isonitrile: dosimetry and resting cardiac imaging with positron emission tomography.
abstract: BACKGROUND
  Development of a positron-emitting form of technetium has allowed the imaging of technetium radiopharmaceuticals with positron emission tomography (PET). We used 94mTc to compare the distribution of the myocardial perfusion agent sestamibi at rest with the conventional PET perfusion tracer 13N-labeled ammonia (13N-ammonia).
  
  
  RESULTS
  Dosimetry calculations were performed with the known whole-body distribution of 99mTc-labeled sestamibi. Dynamic PET imaging of 13N-ammonia and 94mTc-labeled sestamibi (94mTc-sestamibi) for 32 minutes was performed in eight patients with previous myocardial infarction. Initial myocardial and extramyocardial distribution of 94mTc-sestamibi was compared with that of 13N-ammonia by qualitative and quantitative analysis. Quantitative comparison of the two tracers was performed with region-of-interest analysis and circumferential profiles. Qualitatively, the cardiac distribution of the tracers was similar in normal and infarcted myocardium. A decrease in the definition of the epicardial and endocardial borders of the heart was seen with 94mTc-sestamibi, presumably because of the lower dose of radionuclide injected. Quantitatively, there was no difference in infarct size, defined prospectively as tracer activity less than 20% of maximum activity for the section, between the two tracers. Circumferential profile analysis with 12-degree radial sections similarly demonstrated no difference in regional cardiac distribution of the tracers.
  
  
  CONCLUSIONS
  These results revealed no significant difference in myocardial uptake compared with 13N-ammonia suggesting that the myocardial uptake of sestamibi correlates with that of myocardial perfusion.
authors.affiliation: William S. Middleton Veterans Administration Hospital/University of Wisconsin Positron Emission Tomography Center, Madison, USA.
authors.forename: C K
authors.initials: CK
authors.lastname: Stone
authors.forename: B T
authors.initials: BT
authors.lastname: Christian
authors.forename: R J
authors.initials: RJ
authors.lastname: Nickles
authors.forename: S B
authors.initials: SB
authors.lastname: Perlman
mesh_terms: D000328:Adult; D000368:Aged; D000641:Ammonia; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D009590:Nitrogen Radioisotopes; D011829:Radiation Dosage; D017256:Technetium Tc 99m Sestamibi; D014055:Tomography, Emission-Computed
chemical_list: D009590:Nitrogen Radioisotopes; D000641:Ammonia; D017256:Technetium Tc 99m Sestamibi