title: Lipid peroxidation in the pancreas and other organs in streptozotocin diabetic rats.
abstract: We studied the relationship between changes in lipid peroxides and those in catalase activity in pancreases, livers and hearts of streptozotocin-induced diabetic rats. Animals were killed 2 or 7 weeks after saline or streptozotocin (32 mg/kg, i.v.) injection. The levels of blood glucose and plasma insulin in the 2-week streptozotocin-treated rats were 176.8+/-20.5 mg/dl and 29.9+/-3.2 microU/ml, respectively. In the pancreas, the lipid peroxide level significantly decreased and the catalase activity significantly increased 2 weeks after streptozotocin injection. These changes recovered after 7 weeks. In the heart, the lipid peroxide level significantly increased without any change of catalase activity 2 weeks after the initiation of diabetes. After 7 weeks, the catalase activity significantly increased and the lipid peroxide level returned to the control level. In the liver, there was no change in the lipid peroxides and catalase in the 2-week streptozotocin-treated rats, whereas the catalase activity significantly increased 7 weeks after the injection. It was suggested that the defense system in the pancreas to oxidative stress may be evoked in an early stage of streptozotocin-induced diabetes.
authors.affiliation: Department of Pharmacology, Hokkaido College of Pharmacy, Otaru, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Tatsuki
authors.forename: K
authors.initials: K
authors.lastname: Satoh
authors.forename: A
authors.initials: A
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Hoshi
authors.forename: K
authors.initials: K
authors.lastname: Ichihara
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D015227:Lipid Peroxidation / Q000502:physiology*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D007328:Insulin; D002374:Catalase