title: Ethics of randomized clinical trials.
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA 02115-6084, USA. eemanuel@nih.gov
authors.forename: E J
authors.initials: EJ
authors.lastname: Emanuel
authors.forename: W B
authors.initials: WB
authors.lastname: Patterson
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000523:psychology; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000523:psychology; D002945:Cisplatin / Q000008:administration & dosage; D032882:Comprehension; D003520:Cyclophosphamide / Q000008:administration & dosage; D030881:Disclosure; D004317:Doxorubicin / Q000008:administration & dosage; D028663:Ethical Theory; D004992:Ethics, Medical; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D010344:Patient Advocacy; D026684:Personal Autonomy; D010817:Physician-Patient Relations; D011368:Professional-Family Relations; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic / Q000523:psychology / Q000592:standards*; D035844:Researcher-Subject Relations; D018570:Risk Assessment; D036302:Therapeutic Human Experimentation; D035501:Uncertainty
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D017239:Paclitaxel; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate