Treatment of congestive heart failure in the elderly: emphasis on renal functional changes and impact of therapy.
Congestive heart failure (CHF) is a syndrome in which the kidney plays a fundamental role, as sodium retention is a hallmark of the syndrome. An additional hallmark of CHF is that it affects the elderly disproportionately. This high incidence of CHF in the elderly is complicated by age-related alterations in renal hemodynamics and tubular function. In view of these age-related renal alterations, pharmacologic therapy for CHF in the elderly needs to be closely monitored. In addition, recent understanding of neurohumoral mechanisms of CHF has led to new therapeutic options for the treatment of CHF, which are reviewed here.
Chau
W L
WL
Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Burnett
J C
JC
D000368:Aged; D000375:Aging / Q000502:physiology*; D009320:Atrial Natriuretic Factor / Q000096:biosynthesis / Q000187:drug effects*; D002317:Cardiovascular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016232:Endothelins / Q000096:biosynthesis / Q000187:drug effects*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D007677:Kidney Function Tests; D008297:Male; D012016:Reference Values; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology
D002317:Cardiovascular Agents; D016232:Endothelins; D009320:Atrial Natriuretic Factor