[Changes in thyroid function in rats after administration of methylene blue and interactions with estrogens and acetylsalicylic acid].
We have studied the thyroxine and triiodothyronine concentrations in male rats--the control, groups treated separately with estradiol benzoate, acetylsalicylic acid and methylene blue and with combinations of these substances. We have found out that the treatment with acetylsalicylic acid significantly lowers the thyroxine and triiodothyronine serum concentrations. The estradiol benzoate as well as methylene blue inhibited the drop in the serum thyroxine level when administered simultaneously with acetylsalicylic acid. The serum triiodothyronine decrease after acetylsalicylic acid treatment was inhibited by methylene blue and estradiol benzoate only in one of our two experiments. The simultaneous treatment with estradiol benzoate, acetylsalicylic acid and methylene blue did not change the triiodothyronine concentration comparing to control group and decreased the thyroxine serum concentration.
Haluzík
M
M
Laborator pro endokrinologii a metabolismus III. interní kliniky 1. lékarské fakulty Univerzity Karlovy, Praha, Czech Republic.
Nedvídková
J
J
Schreiber
V
V
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008751:Methylene Blue / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; C074283:estradiol 3-benzoate; D004958:Estradiol; D013974:Thyroxine; D001241:Aspirin; D008751:Methylene Blue