Interaction of Interceed oxidized regenerated cellulose with macrophages: a potential mechanism by which Interceed may prevent adhesions.
OBJECTIVE
The objective of the study was to determine whether Interceed oxidized regenerated cellulose (Johnson & Johnson Medical, Arlington, Tex.), because of its polyanionic nature, may compete for the macrophage scavenger receptor.


METHODS
RAW macrophages were incubated with Interceed oxidized regenerated cellulose and known scavenger receptor ligands. The production of interleukin-1beta by mouse peritoneal macrophages was measured in the presence of Interceed cellulose.


RESULTS
When macrophages were incubated with Interceed cellulose, increasing concentrations inhibited the uptake of fluorescent acetyl low-density lipoprotein. In the presence of Interceed cellulose there was a decrease in the production of interleukin-1beta by mouse macrophages.


CONCLUSIONS
These results suggest that the interaction of Interceed oxidized regenerated cellulose with macrophages with scavenger receptors may result in a decreased secretion of matrix components, inflammatory mediators, and cellular growth factors. Thus Interceed cellulose may function as a biologic barrier in preventing adhesions.
Reddy
S
S
Department of Obstetrics and Gynecology, Emory University, Atlanta, Georgia 30322, USA.
Santanam
N
N
Reddy
P P
PP
Rock
J A
JA
Murphy
A A
AA
Parthasarathy
S
S
D000818:Animals; D001667:Binding, Competitive; D002478:Cells, Cultured; D002483:Cellulose, Oxidized / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D008077:Lipoproteins, LDL / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects*; D017737:Macrophages, Peritoneal / Q000378:metabolism; D051379:Mice; D011971:Receptors, Immunologic / Q000378:metabolism; D051116:Receptors, Scavenger; D000267:Tissue Adhesions / Q000517:prevention & control
D002483:Cellulose, Oxidized; C060002:INTERCEED; D007375:Interleukin-1; D008077:Lipoproteins, LDL; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; C032629:acetyl-LDL