title: Antibiotic and antithromboembolic prophylaxis in hip arthroplasty (a review of 700 primary implants).
abstract: The authors report the results obtained with antibiotic and antithromboembolic prophylaxis used in 700 consecutive primary total hip arthroplasties. As for antibiotic prophylaxis (5 cases of infection: 0.7%) the various types of antibiotic used always kept the infection rate under 1%, confirming the effectiveness of the preventive use of antibioticotherapy. The incidence of deep venous thrombosis and pulmonary embolia were 3.7% and 0.7%, respectively (26 cases of DVT and 5 of PET). The incidence of DVT rose to 34.4% in a selected group of cases in which phlebography had been carried out even in the absence of symptoms of DVT. This confirms that the routine use of this method would without a doubt be useful in preventing complications with a high risk for the life of the patient (pulmonary embolia). As for pharmacological prophylaxis, indobufene and calcium heparin were the drugs used most: their effectiveness was nearly similar, despite the fact that the use of calcium heparin in patients considered to be at a higher risk for thromboembolic complications should be made clear.
authors.affiliation: Clinica Ortopedica dell'Università, Istituto Ortopedico Rizzoli, Bologna.
authors.forename: L
authors.initials: L
authors.lastname: Busanelli
authors.forename: A
authors.initials: A
authors.lastname: Toni
authors.forename: A
authors.initials: A
authors.lastname: Sudanese
authors.forename: M
authors.initials: M
authors.lastname: Testoni
authors.forename: B
authors.initials: B
authors.lastname: Borghi
authors.forename: M
authors.initials: M
authors.lastname: Montebugnoli
authors.forename: F
authors.initials: F
authors.lastname: Fanton
authors.forename: D
authors.initials: D
authors.lastname: Ferrari
authors.forename: A
authors.initials: A
authors.lastname: Giunti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods*; D001804:Blood Transfusion, Autologous; D002437:Cefazolin / Q000627:therapeutic use; D002439:Cefotaxime / Q000008:administration & dosage; D002511:Cephalosporins / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000517:prevention & control*; D013923:Thromboembolism / Q000188:drug therapy / Q000517:prevention & control*; D013924:Thrombophlebitis / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D002511:Cephalosporins; D002437:Cefazolin; D002439:Cefotaxime