Systemic absorption of gentamicin ear drops.
Aminoglycoside-containing topical preparations are commonly used in the treatment of chronic suppurative otitis media and otitis externa. We report a case where systemic absorption of topical Gentisone HC occurred producing a serum gentamicin level of 6.2 micrograms/ml.
Green
K M
KM
Department of Otolaryngology, Royal Preston Hospital, UK.
Lappin
D W
DW
Curley
J W
JW
de Carpentier
J P
JP
D000042:Absorption; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005839:Gentamicins / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D008297:Male; D008875:Middle Aged; D010035:Otitis Media, Suppurative / Q000097:blood* / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D005839:Gentamicins