Immunohistochemical distribution of type IV collagenase in normal, dysplastic and neoplastic canine mammary gland.
The distribution of type IV collagenase (cIVase) was evaluated immunohistochemically in a series of normal, dysplastic and neoplastic canine mammary glands, as well as in lymph node metastases. In normal and dysplastic mammary tissues, and benign mammary tumours, cIVase was observed in myoepithelial cells, but in malignant tumours it was mainly localized in the cytoplasm of carcinoma cells and fibroblasts close to infiltrating neoplastic cells. No significant difference was observed between carcinomas of different histological sub-types. These results suggest that the distribution of cIVase is a potentially useful indicator of malignancy in canine mammary tumours.
Papparella
S
S
Dipartimento di Patologia, di Profilassi e di Ispezione degli Alimenti, Facoltà di Medicina Veterinaria, Università Federico II, Naples, Italy.
Restucci
B
B
Maiolino
P
P
De Vico
G
G
D000818:Animals; D017364:Collagenases / Q000032:analysis*; D004285:Dogs; D005348:Fibrocystic Breast Disease / Q000201:enzymology* / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000201:enzymology / Q000473:pathology; D008207:Lymphatic Metastasis; D008321:Mammary Glands, Animal / Q000201:enzymology* / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000201:enzymology* / Q000473:pathology; D020780:Matrix Metalloproteinase 9; D009362:Neoplasm Metastasis
D017364:Collagenases; D020780:Matrix Metalloproteinase 9