Effects of rebamipide, a novel anti-ulcer agent, on gastric mucosal injury induced by platelet-activating factor in rats.
We examined the role of gastric mucosal blood flow, lipid peroxidation, and neutrophil accumulation mediated by platelet-activating factor in the protective effect of rebamipide against gastric mucosal injury in rats. The intravenous injection of platelet-activating factor induced hyperemia and hemorrhagic erosions in rat stomachs. Rebamipide did not affect the decrease in the gastric mucosal blood flow induced by platelet-activating factor. The increase in gastric injury score after platelet-activating factor injection and the increase in thiobarbituric acid-reactive substances were significantly inhibited by the administration of rebamipide. The gastric injury score was closely correlated with the accumulation of lipid peroxides. Tissue-associated myeloperoxidase activity in the gastric mucosa significantly increased after platelet activating factor injection; this increase was not influenced by rebamipide treatment. The protective effect of rebamipide against the platelet-activiting factor-induced gastric mucosal injury may be due to direct inhibition of lipid peroxidation or scavenging of oxygen radicals that initiate lipid peroxidation.
Kokura
S
S
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Yoshikawa
T
T
Naito
Y
Y
Ichikawa
H
H
Takano
H
H
Takahashi
S
S
Tomii
T
T
Yoshida
N
N
Kondo
M
M
D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D010972:Platelet Activating Factor / Q000506:poisoning*; D015363:Quinolones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000897:Anti-Ulcer Agents; D008054:Lipid Peroxides; D010972:Platelet Activating Factor; D015363:Quinolones; D009195:Peroxidase; C052785:rebamipide; D000409:Alanine