[Proteins of the nuclear matrix and their phosphorylation in normal and tumor cells].
The protein composition of the nuclear matrix of normal and tumor cells is discussed. A characteristic feature of the latter is the predominance of high molecular weight polypeptides containing mainly glyco- and phosphoproteins. Only few of them are identified. Nuclear matrix preparations from tumors differ by the presence of fibronectin and phosphotyrosine-containing proteins with a molecular mass of nearly 180 and 170 kDa as well as of high turnover of high molecular weight protein group and inhibition of their biosynthesis by chloramphenicol.
Zbarskiĭ
I B
IB
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D006367:HeLa Cells; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000737:chemistry* / Q000378:metabolism; D009363:Neoplasm Proteins / Q000737:chemistry* / Q000378:metabolism; D015530:Nuclear Matrix / Q000737:chemistry* / Q000378:metabolism; D009687:Nuclear Proteins / Q000737:chemistry* / Q000378:metabolism; D010766:Phosphorylation
D009363:Neoplasm Proteins; D009687:Nuclear Proteins