title: Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation.
abstract: The effects of a fish-enriched diet or dietary supplements consisting of either fish oil or a docosahexaenoic acid-rich oil (DHA-oil) on platelet aggregation and hemostatic factors were studied in healthy male students. After an experimental period of 15 weeks, the levels of tissue factor pathway inhibitor, prothrombin fragment 1+2 and fibrinogen as well as factor VII activity were not changed. Factor X activity was slightly decreased by the fish diet (P < 0.05). Collagen but not ADP-induced maximum platelet aggregation decreased in the fish diet and the fish oil groups (P < 0.05 in both). In the DHA-oil group there was a slight, statistically insignificant, increase of platelet aggregation which correlated significantly with the decrease of plasma triglycerides. Platelet aggregation measured 4 h after a standardized fat meal was lower than in the fasting state and this decrease correlated with the increase of plasma triglycerides. These results show that a fish diet and fish oil, but not DHA-oil, inhibit in vitro platelet aggregation and that hemostatic factors are not affected by moderate n-3 fatty acid supplementation.
authors.affiliation: Department of Physiology, University of Kuopio, Finland. Jyrki.Agren@uku.fi
authors.forename: J J
authors.initials: JJ
authors.lastname: Agren
authors.forename: S
authors.initials: S
authors.lastname: Väisänen
authors.forename: O
authors.initials: O
authors.lastname: Hänninen
authors.forename: A D
authors.initials: AD
authors.lastname: Muller
authors.forename: G
authors.initials: G
authors.lastname: Hornstra
mesh_terms: D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000187:drug effects* / Q000378:metabolism; D004032:Diet; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000378:metabolism / Q000494:pharmacology*; D005395:Fish Oils / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology
chemical_list: D001779:Blood Coagulation Factors; D005395:Fish Oils; D004281:Docosahexaenoic Acids