title: [T-cell-rich B-cell lymphoma. Presentation of 3 cases].
abstract: T-cell-rich B-cell lymphoma (TBL) is a rare entity not included in the classical classifications of non-Hodgkin's lymphomas (NHL), presenting usually at diagnosis in advanced stages and with extranodal involvement. Its differential diagnosis, based on immunophenotyping technics, include other entities with different treatment and prognosis, mainly lymphocytic-predominance Hodgkin disease and peripheral T-cell lymphoma; this differential diagnosis has importance in patient's survival. We present 3 patients, two males (one of them with HIV infection) and one female, aged 38, 60 and 64 respectively, diagnosed as having TBL. The two former patients presented advanced stages at diagnosis. None of them was initially diagnosed as having TBL, the diagnosis were immunoblastic NHL in the first patient, peripheral T-cell lymphoma in the second and mixed cellularity Hodgkin's disease in the third one. The first patient was not treated due to rapid worsening and early death of septic shock; the other two cases were treated with COP-BLAM/IMVP-16 protocol achieving partial and complete remission respectively after 6 cycles of treatment. Comments about clinical, pathological and differential diagnostic aspects are made.
authors.affiliation: Servicio de Hematología, Hospital Juan Ramón Jiménez, Huelva.
authors.forename: J N
authors.initials: JN
authors.lastname: Rodríguez
authors.forename: J J
authors.initials: JJ
authors.lastname: Borrero
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Jurado
authors.forename: R
authors.initials: R
authors.lastname: Creagh
authors.forename: M L
authors.initials: ML
authors.lastname: Martino
authors.forename: M
authors.initials: M
authors.lastname: Aguayo
authors.forename: D
authors.initials: D
authors.lastname: Prados
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003951:Diagnostic Errors; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology*; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000145:classification* / Q000175:diagnosis / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis; D016176:T-Lymphocyte Subsets / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor