Schizophrenia, psychosis, and the basal ganglia.
Schizophrenia is one of the most common and perhaps the most disabling of mental disorders, for which effective forms of treatment have not yet been established definitively. The findings reviewed in this article strongly suggest that basal ganglia abnormalities are involved in the pathophysiology of psychotic syndromes in general, and schizophrenia in particular.
Busatto
G F
GF
Department of Psychiatry, Faculdade de Medicina da Universidade de São Paulo, Brazil.
Kerwin
R W
RW
D014150:Antipsychotic Agents / Q000494:pharmacology; D001479:Basal Ganglia / Q000473:pathology / Q000503:physiopathology; D001526:Behavioral Symptoms / Q000503:physiopathology; D006801:Humans; D009483:Neuropsychological Tests; D011618:Psychotic Disorders / Q000503:physiopathology*; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D012559:Schizophrenia / Q000209:etiology* / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D014150:Antipsychotic Agents; D017448:Receptors, Dopamine D2; D005680:gamma-Aminobutyric Acid