title: Rapid and transient lymphocytopenia after i.v. administration of high doses of human recombinant erythropoietin.
abstract: The effect of administration of human recombinant erythropoietin on leukocytic cells has been evaluated. In humans the administration of 20,000 U i.v. of rHuEPO caused a rapid and transitory leukopenia that seemed to be caused by a preferential reduction of lymphocytes (2715 +/- 513 mm3 t 0; 1898 +/- 506 t 60', p < 0.002). Pretreatment with imidazole-2-hydroxybenzoate, a drug capable of inhibiting the synthesis of prostaglandins, caused a less marked and later reduction of lymphocytes (2242 +/- 477 t 0; 1560 +/- 318 t 180 minutes, p < 0.001). A less marked and later lymphocytopenia was also shown in subjects affected by chronic renal insufficiency (2907 +/- 726 t 0; 1944 +/- 512 t 180 minutes, p < 0.005).
authors.affiliation: Department of Internal Medicine, University of Messina, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Buemi
authors.forename: A
authors.initials: A
authors.lastname: Allegra
authors.forename: F
authors.initials: F
authors.lastname: Corica
authors.forename: G
authors.initials: G
authors.lastname: Cavallaro
authors.forename: C
authors.initials: C
authors.lastname: Aloisi
authors.forename: G
authors.initials: G
authors.lastname: Pettinato
authors.forename: N
authors.initials: N
authors.lastname: Frisina
mesh_terms: D004921:Erythropoietin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008231:Lymphopenia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin