title: Protein acetylation: more than chromatin modification to regulate transcription.
abstract: Histone acetyltransferases and deacetylases are involved in the regulation of gene transcription. Recently, tumor suppressor protein p53 has been shown to be a target for transcriptional coactivators that have histone acetyltransferase activity, suggesting acetylation is also involved in the regulation of cell proliferation and tumorigenesis.
authors.affiliation: Department of Pathology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Bayle
authors.forename: G R
authors.initials: GR
authors.lastname: Crabtree
mesh_terms: D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000378:metabolism* / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D002843:Chromatin; D011506:Proteins