Staphylococcus aureus cap5O and cap5P genes functionally complement mutations affecting enterobacterial common-antigen biosynthesis in Escherichia coli.
The Staphylococcus aureus cap5P and cap5O genes of the type 5 capsule biosynthetic locus restore enterobacterial common-antigen expression to Escherichia coli mutants defective in rffE and rffD gene expression, respectively. Cap5P and Cap5O likely function as UDP-GlcNAc 2-epimerase and UDP-ManNAc dehydrogenase enzymes, respectively, in the synthesis of the capsule precursor UDP-ManNAcA.
Kiser
K B
KB
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Lee
J C
JC
D000942:Antigens, Bacterial / Q000235:genetics*; D002240:Carbohydrate Sequence; D004926:Escherichia coli / Q000235:genetics* / Q000276:immunology; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D008969:Molecular Sequence Data; D009154:Mutation; D013211:Staphylococcus aureus / Q000235:genetics* / Q000276:immunology
D000942:Antigens, Bacterial