HIV infection and HIV-1 clades among pregnant women in Harare, Zimbabwe.
OBJECTIVE
To determine HIV-1 seropositivity and HIV-1 clades/subtypes among pregnant women attending different clinics in Harare, Zimbabwe.


METHODS
A prospective study.


METHODS
206 pregnant women attending Edith Opperman and Budiriro clinics in Harare.


METHODS
Frequency distribution of the various HIV-1 clades and rate of HIV-1 seropositivity.


RESULTS
Results obtained showed that out of the 206 pregnant women screened, 60 (29.1%) were HIV-1 seropositive. The most predominant clade was HIV-1 clade C (66.6%) whereas HIV-1 clades A and B accounted for 48.3% and 33.3% of HIV-1 clades respectively. Results also revealed dual infections with clades A and C (45%), A and D (10%), B and C (30%) and multiple infections with A, B, C and D (6.6%) whereas two (3.3%) were non-reactive.


CONCLUSIONS
Finally, the data on HIV-1 clades are of immense immunological, molecular and epidemiological importance in Harare, Zimbabwe and should serve as base line data for future investigations in the country.
Obi
C L
CL
Department of Medical Microbiology, University of Zimbabwe Medical School, Avondale, Harare, Zimbabwe.
McAdoo
H P
HP
Murray
M
M
Tswana
S A
SA
Moyo
S R
SR
D000595:Amino Acid Sequence; D004279:DNA, Viral / Q000737:chemistry*; D005260:Female; D006679:HIV Seropositivity / Q000821:virology*; D015528:HIV Seroprevalence; D015497:HIV-1 / Q000145:classification* / Q000235:genetics; D006801:Humans; D008403:Mass Screening; D008969:Molecular Sequence Data; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000821:virology*; D011446:Prospective Studies; D012703:Serotyping; D014504:Urban Health; D015030:Zimbabwe
D004279:DNA, Viral