A new method to modify the C-4 position of 10-deacetylbaccatin III.
We have developed a new method to modify the C-4 position of 10-deacetylbaccatin III (5) using the C-4 acetoxy anion of the 13-keto derivative (7) and various alkyl halides. The method developed herein should be very useful for the preparation of C-4 modified taxoid analogs.
Uoto
K
K
New Product Research Laboratories IV, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Takenoshita
H
H
Ishiyama
T
T
Terasawa
H
H
Soga
T
T
D000478:Alkylation; D017239:Paclitaxel / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D043823:Taxoids; D014315:Triterpenes / Q000737:chemistry*
D043823:Taxoids; D014315:Triterpenes; C042213:10-deacetylbaccatine III; D017239:Paclitaxel