In vivo effect of oral albendazole and albendazole sulphoxide on development of secondary echinococcosis in mice.
This paper describes the effectiveness of ABZ, ABZ.SO and ABZ + ABZ.SO treatment in mice infected with Echinococcus granulosus protoscoleces. The results were evaluated in two ways: measuring the number and wet weight of developed cysts and by transmission electron microscopy (TEM) of tissue cyss. ABZ and ABZ + ABZ.SO had an important effect upon larval growth in E. granulosus. The ultrastructural changes noted were: vacuolation of tegumentary cells of the germinal membrane; increased number of mitochondria; increased number of autophagosomes and an increase in lipid deposits.
Pérez-Serrano
J
J
Laboratory of Parasitology, Faculty of Pharmacy, University of Alcalá de Henares, Madrid, Spain. mpperez@microb.alcala.es
Denegri
G
G
Casado
N
N
Rodríguez-Caabeiro
F
F
D000284:Administration, Oral; D015766:Albendazole / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004338:Drug Combinations; D004443:Echinococcosis / Q000473:pathology / Q000628:therapy*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains
D000871:Anthelmintics; D004338:Drug Combinations; D015766:Albendazole; C027186:albendazole sulfoxide