Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1-->S-phase progression.
Withdrawal from the cell cycle as cells begin to differentiate is accomplished by the downregulation of cyclin-dependent kinase activities in G1 phase. Recent analysis of loss-of-function mutations in flies, worms, and mice has provided insight into the roles of various negative regulators of G1 phase in developing organisms.
Zavitz
K H
KH
Department of Biological Chemistry, School of Medicine, University of California at Los Angeles 90095, USA. zavitz@hhmi.ucla.edu
Zipursky
S L
SL
D000818:Animals; D017173:Caenorhabditis elegans; D018797:Cell Cycle Proteins; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D002455:Cell Division / Q000235:genetics* / Q000502:physiology*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D004330:Drosophila; D016193:G1 Phase / Q000235:genetics / Q000502:physiology; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D016196:S Phase / Q000235:genetics / Q000502:physiology; D025521:Tumor Suppressor Proteins
C493961:Cdkn1b protein, mouse; D018797:Cell Cycle Proteins; D008869:Microtubule-Associated Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D018844:Cyclin-Dependent Kinases