title: Nonneoplastic disorders of the eccrine glands.
abstract: Eccrine glands are uniquely susceptible to a variety of pathologic processes. Alteration in the rate of sweat secretion manifests as hypohidrosis and hyperhidrosis. Obstruction of the eccrine duct leads to miliaria. The excretion of drugs into eccrine sweat may be a contributory factor in neutrophilic eccrine hidradenitis (NEH), syringosquamous metaplasia (SSM), coma bulla, and erythema multiforme (EM). Alterations in the electrolyte composition of eccrine sweat can be observed in several systemic diseases, most notably cystic fibrosis. This article summarizes current knowledge of eccrine gland pathophysiology.
authors.affiliation: Department of Dermatology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA.
authors.forename: F G
authors.initials: FG
authors.lastname: Wenzel
authors.forename: T D
authors.initials: TD
authors.lastname: Horn
mesh_terms: D000328:Adult; D001768:Blister / Q000139:chemically induced; D002648:Child; D003128:Coma / Q000139:chemically induced; D003550:Cystic Fibrosis / Q000378:metabolism; D004198:Disease Susceptibility; D064420:Drug-Related Side Effects and Adverse Reactions; D004439:Eccrine Glands / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D004573:Electrolytes / Q000032:analysis; D004892:Erythema Multiforme / Q000139:chemically induced; D016575:Hidradenitis / Q000139:chemically induced; D006801:Humans; D006945:Hyperhidrosis / Q000209:etiology / Q000503:physiopathology; D007007:Hypohidrosis / Q000209:etiology / Q000503:physiopathology; D008679:Metaplasia; D008883:Miliaria / Q000209:etiology / Q000503:physiopathology; D013542:Sweat / Q000737:chemistry / Q000378:metabolism; D013543:Sweat Gland Diseases / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology
chemical_list: D004573:Electrolytes