Administration of desipramine at infancy reduces dorsal striatal serotonin metabolism at adolescence in the rat.
Desipramine, a monoamine uptake inhibiting antidepressant, was given at infancy to male and female rats and the effects of its administration on the metabolism of dorsal striatal monoamines at adolescence were examined. Desipramine, 5 mg/kg s.c., was administered once a day from the 6th to the 20th postnatal day. Rats were decapitated at the postnatal age of one month and the concentrations of monoamines and their metabolites in dorsal striata were analyzed using high performance liquid chromatography with electrochemical detection. Desipramine decreased the concentration of 5-hydroxyindole-acetic acid by 22%. Other monoamines, their metabolites or metabolite/monoamine ratios were not affected. We conclude that desipramine given systemically at infancy reduces dorsal striatal metabolism of serotonin at adolescence in the rat.
Hilakivi
I
I
Department of Physiology, Faculty of Medicine, University of Helsinki, Finland.
Attila
M
M
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D015306:Biogenic Monoamines / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology*; D005260:Female; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D000929:Antidepressive Agents, Tricyclic; D015306:Biogenic Monoamines; D012701:Serotonin; D003891:Desipramine