title: Will genetics really revolutionize the drug discovery process?
abstract: Genetics has played only a modest role in drug discovery, but new technologies will radically change this. Whole genome sequencing will identify new drug discovery targets, and emerging methods for the determination of gene function will increase the ability to select robust targets. Detection of single nucleotide polymorphisms and common polymorphisms will enhance the investigation of polygenic diseases and the use of genetics in drug development. Oligonucleotide arraying technologies will allow analysis of gene expression patterns in novel ways.
authors.affiliation: Applied Genomics and Metabolic Diseases, Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. Gelbert@bms.com
authors.forename: L M
authors.initials: LM
authors.lastname: Gelbert
authors.forename: R E
authors.initials: RE
authors.lastname: Gregg
mesh_terms: D015195:Drug Design; D014644:Genetic Variation; D015698:Genomic Library; D006801:Humans; D008490:Medical Informatics; D008957:Models, Genetic; D008967:Molecular Biology