Synthesis of 6-methyl[11C]-2'-deoxyuridine and evaluation of its in vivo distribution in Wistar rats.
In this study, 6-methyl-2'-deoxyuridine, an artificial nucleoside, was labeled with 11C in the methyl position. Tissue distribution of 6-methyl[11C]-2'-deoxyuridine was investigated in normal Wistar rats and compared to the behavior of the natural nucleoside [methyl-11C]thymidine. High renal clearance, up to at least 20% of the injected activity, was noticed during the 20 min period following injection. Tissue distribution as determined by dynamic PET studies of both 11C-labeled nucleosides was significantly different for most of the organs.
Goethals
P
P
Department of Analytical Chemistry, Institute for Nuclear Sciences, University of Gent, Belgium. PatrickP.Goethals@rug.ac.be
Volders
F
F
Van der Eycken
J
J
van Eijkeren
M
M
Lemahieu
I
I
Dams
R
R
D000818:Animals; D002250:Carbon Radioisotopes / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013936:Thymidine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
C110579:6-methyl-2'-deoxyuridine; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; C012439:methylthymidine; D013936:Thymidine; D003857:Deoxyuridine