Paraneoplastic syndromes.
Most nervous system paraneoplastic syndromes probably result from an immune attack against antigens normally expressed only in the nervous system but aberrantly expressed in a cancer. Specific antibodies in serum and cerebrospinal fluid that react with the nervous system and the cancer can be used to characterize proteins usually restricted to the nervous system and to identify neurologic disorders as paraneoplastic caused by a specific tumor type.
Posner
J B
JB
Memorial Sloan-Kettering Cancer Center, Department of Neurology, New York, NY 10021, USA. Posner.J@mskcc.org
D000818:Animals; D006801:Humans; D009423:Nervous System Neoplasms / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D010257:Paraneoplastic Syndromes / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy