title: Use of the Sensormedics MCT Accelerator in sputum induction.
abstract: Airway inflammation can be studied by obtaining sputum induced by inhalation of 3% saline. The Sensormedics MCT accelerator is an oral asymmetrical high frequency oscillator which safely enhances clearance of airway secretions. The aim of this study was to determine if use of the MCT Accelerator enhances sputum production in non-asthmatic non-atopic, atopic and asthmatic subjects. Fifteen subjects were studied over 3 days. On day 1 skin prick testing to common aeroallergens and methacholine bronchial reactivity were performed. On days 2 and 3, separated by 7 days, sputum was induced by inhalation of 3% saline alone for 30 mins or via the nebulizer port of the MCT Accelerator. The cellular profile and volume of sputum were analysed. The use of the MCT Accelerator did not alter the cellular profile of the induced sputum nor was there an increase in volume. In conclusion the induction of sputum by inhalation of 3% saline was not altered by use of the MCT Accelerator.
authors.affiliation: Department of Thoracic Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia.
authors.forename: M A
authors.initials: MA
authors.lastname: McClean
authors.forename: P I
authors.initials: PI
authors.lastname: Field
authors.forename: M J
authors.initials: MJ
authors.lastname: Matheson
authors.forename: R
authors.initials: R
authors.lastname: Simmul
authors.forename: N
authors.initials: N
authors.lastname: Berend
mesh_terms: D001249:Asthma / Q000175:diagnosis*; D018893:Bronchoalveolar Lavage / Q000295:instrumentation* / Q000379:methods; D002452:Cell Count; D006801:Humans; D012016:Reference Values; D012462:Saline Solution, Hypertonic; D012680:Sensitivity and Specificity; D013183:Sputum / Q000166:cytology / Q000378:metabolism*
chemical_list: D012462:Saline Solution, Hypertonic