Is CTLA-4 a negative regulator for T-cell activation?
Immune responses can be a two-sided sword: although lack of immunity can be fatal, so can over-activation of the immune system. The concept of homeostatic balance in immune regulation has consequently been at the core of immune research. In this context, Yang Liu takes a cautious view of the concept that CTLA-4 is a negative regulator of T-cell activation.
Liu
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Michael Heidelberger Division of Immunology, Dept of Pathology, New York University Medical Center, NY 10016, USA. liuy01@mcrcr6.med.nyu.edu
D000069594:Abatacept; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000276:immunology / Q000502:physiology*; D060908:CTLA-4 Antigen; D007108:Immune Tolerance; D018796:Immunoconjugates; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556707:Ctla4 protein, mouse; D018796:Immunoconjugates; D000069594:Abatacept