Toxic epidermal necrolysis treated with cyclosporin and granulocyte colony stimulating factor.
A patient developed toxic epidermal necrolysis while on carbamazepine, 80% of her skin surface being involved. She also developed a pancytopenia with a neutropenia of 0.77 x 10(9)/l (normal range 2-7.5 x 10(9)/l), but was treated with cyclosporin and granulocyte colony stimulating factor and made a full recovery.
Jarrett
P
P
Department of Dermatology, Health Waikato, New Zealand.
Rademaker
M
M
Havill
J
J
Pullon
H
H
D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D002220:Carbamazepine / Q000009:adverse effects; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009503:Neutropenia / Q000139:chemically induced / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000628:therapy*
D018712:Analgesics, Non-Narcotic; D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D002220:Carbamazepine; D016572:Cyclosporine; D000069585:Filgrastim