CD40 and its ligand in cell-mediated immunity.
CD40 and its ligand (gp39, CD40L, TBAM) is central to the control of thymus-dependent humoral immunity. However, in recent years it has become evident that CD40 signaling also is critical in the development of cell-mediated immune responses. How CD40 regulates cell-mediated immunity is discussed.
Noelle
R J
RJ
Department of Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA.
D000818:Animals; D000938:Antigen-Presenting Cells; D001402:B-Lymphocytes / Q000276:immunology; D019013:CD40 Antigens / Q000276:immunology*; D023201:CD40 Ligand; D006801:Humans; D007111:Immunity, Cellular; D008562:Membrane Glycoproteins / Q000276:immunology; D013601:T-Lymphocytes
D019013:CD40 Antigens; D008562:Membrane Glycoproteins; D023201:CD40 Ligand