title: Development of a therapeutic vaccine for the treatment of cocaine addiction.
abstract: No pharmacotherapies have yet been approved for the treatment of cocaine addiction. One new approach is to block the effects of cocaine with anti-cocaine antibodies induced by a therapeutic cocaine vaccine. A cocaine vaccine has been developed which induces a cocaine-specific antibody response in rodents. The antibody binds to cocaine in the circulation and can be shown to inhibit the ability of cocaine to enter the brain. Furthermore, anti-cocaine antibody can inhibit cocaine self-administration in rats. These data suggest that a cocaine vaccine may be a powerful therapeutic tool. The intent is to immunized motivated patients with the vaccine as part of a comprehensive treatment program. If the patient uses cocaine after being vaccinated, the antibody will inhibit the reinforcing activity of cocaine and decrease the likelihood of relapse.
authors.affiliation: ImmuLogic Pharmaceutical Corporation, Waltham, MA 02154, USA. FoxB@ImmuLogic.com
authors.forename: B S
authors.initials: BS
authors.lastname: Fox
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000494:pharmacology; D016739:Behavior, Addictive / Q000188:drug therapy; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D002352:Carrier Proteins / Q000494:pharmacology; D003042:Cocaine / Q000008:administration & dosage / Q000097:blood / Q000276:immunology* / Q000493:pharmacokinetics; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007116:Immunization, Passive; D051379:Mice; D051381:Rats; D012651:Self Medication; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D014612:Vaccines / Q000494:pharmacology*
chemical_list: D000936:Antigen-Antibody Complex; D002352:Carrier Proteins; D014612:Vaccines; D012710:Serum Albumin, Bovine; D003042:Cocaine