[Immunology and progestins in pregnancy].
Indications for a relationship of corpus luteum/progesterone and rate of abortions are well known for some time. Measurement of progesterone and clinical observations could demonstrate, that low serum progesterone levels indicate even better than HCG-measurements an abnormal course of pregnancy. Early substitution seems to be the decisive therapeutic measurement. Progesterone leads in relation to the concentration at the feto-maternal interface to direct and indirect suppression of T-cell reactions. Progesterone acts synergistically with prostaglandin E2 immunosuppressive. The interleukin 2-induced cellular cytotoxity is suppressed. Progesterone induces a number of proteins such as PP 14, which inhibit the activity of T-cells and killer cells. The mitogenic lymphocyte reactivity is lowered. The results of immunological therapies up to now do not give proof of the effectiveness of immunological treatment modalities.
Schindler
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AE
Zentrum für Frauenheilkunde, Universitätsklinikum Essen.
D000818:Animals; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D007231:Infant, Newborn; D008213:Lymphocyte Activation / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011374:Progesterone / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
D011374:Progesterone