Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes.
The effect of immunization with either a Porphyromonas gingivalis fimbrial protein, a capsular polysaccharide, or a capsular polysaccharide-fimbrial protein conjugate vaccine were compared in hu-PBL-SCID mice. A significantly higher human immunoglobulin G antibody response and the highest degree of in vivo protection against bacterial challenge was observed in the group immunized with the conjugate vaccine. It was concluded that capsular polysaccharide-fimbrial protein conjugate from P. gingivalis could potentially be developed as a vaccine against periodontal infection by P. gingivalis.
Choi
J I
JI
Department of Pediatrics, University of Rochester, New York 14642, USA. vaccine@cc.urmc.rochester.edu
Schifferle
R E
RE
Yoshimura
F
F
Kim
B W
BW
D018829:Adhesins, Bacterial / Q000276:immunology*; D000818:Animals; D016866:Bacteroidaceae Infections / Q000276:immunology* / Q000517:prevention & control*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology; D017710:Lymphocyte Transfusion; D051379:Mice; D016513:Mice, SCID; D010510:Periodontal Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D016966:Porphyromonas gingivalis / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000276:immunology*
D018829:Adhesins, Bacterial; D007074:Immunoglobulin G; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate