title: Time-domain quanification of amplitude, chemical shift, apparent relaxation time T2, and phase by wavelet-transform analysis. Application to biomedical magnetic resonance spectroscopy.
abstract: The wavelet-transform method is used to quantify the magnetic resonance spectroscopy (MRS) parameters: chemical shift, apparent relaxation time T2, resonance amplitude, and phase. Wavelet transformation is a time-frequency representation which separates each component from the FID, then successively quantifies it and subtracts it from the raw signal. Two iterative procedures have been developed. They have been combined with a nonlinear regression analysis method and tested on both simulated and real sets of biomedical MRS data selected with respect to the main problems usually encountered in quantifying biomedical MRS, specifically "chemical noise," resulting from overlapping resonances, and baseline distortion. The results indicate that the wavelet-transform method can provide efficient and accurate quantification of MRS data.
authors.affiliation: Laboratoire de Résonance Magnétique en Biologie et Médecine, Université de Rennes, Cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Serrai
authors.forename: L
authors.initials: L
authors.lastname: Senhadji
authors.forename: J D
authors.initials: JD
authors.lastname: de Certaines
authors.forename: J L
authors.initials: JL
authors.lastname: Coatrieux
mesh_terms: D000465:Algorithms; D005583:Fourier Analysis; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D012044:Regression Analysis; D012815:Signal Processing, Computer-Assisted