Inhibitory effects of beta-carotene, palm carotene, and green tea polyphenols on pancreatic carcinogenesis initiated by N-nitorsobis(2-oxopropyl)amine in Syrian golden hamsters.
The effects of alpha-carotene, beta-carotene, palm carotene, and green tea polyphenols (GTP) on the progression stage of pancreatic carcinogenesis after rapid production of ductal lesions were studied in Syrian hamsters. Dose threshold inhibitory effects were noted for beta-carotene, 25 ppm, and palm carotene, 40 ppm, which includes 24 ppm beta-carotene reducing the numbers of putative preneoplastic lesions of duct epithelial hyperplasia and atypical hyperplasia, as well as carcinoma in situ and invasive carcinomas. GTP at doses of 500 and 5000 ppm, but not 100 ppm, also significantly decreased the numbers of hyperplasia and total duct lesions. Combined administration of 40 ppm palm carotene, and 50 ppm GTP similarly inhibited the lesion development. Alpha-carotene, however, did not affect pancreatic carcinogenesis. The results suggest that chemopreventive effects are exerted by beta-carotene and GTP above critical doses and that combined administration of palm carotene and GTP might be a candidate chemoprevention strategy for pancreatic cancer in humans.
Majima
T
T
Department of Oncological Pathology, Cancer Center, Nara Medical University, Japan.
Tsutsumi
M
M
Nishino
H
H
Tsunoda
T
T
Konishi
Y
Y
D000818:Animals; D002273:Carcinogens; D002338:Carotenoids / Q000008:administration & dosage / Q000627:therapeutic use; D006224:Cricetinae; D005260:Female; D005419:Flavonoids; D005638:Fruit / Q000737:chemistry*; D008647:Mesocricetus; D009602:Nitrosamines; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D011108:Polymers / Q000008:administration & dosage / Q000627:therapeutic use*; D059808:Polyphenols; D013662:Tea / Q000737:chemistry*; D019207:beta Carotene / Q000008:administration & dosage / Q000627:therapeutic use*
D002273:Carcinogens; D005419:Flavonoids; D009602:Nitrosamines; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013662:Tea; D019207:beta Carotene; D002338:Carotenoids; C041635:alpha-carotene; C013622:nitrosobis(2-oxopropyl)amine