A strategy for anti-viral intervention: the use of alpha-glucosidase inhibitors to prevent chaperone-mediated folding of viral envelope glycoproteins.
Mehta
A
A
Department of Biochemistry, Oxford University, U.K.
Rudd
P M
PM
Block
T M
TM
Dwek
R A
RA
D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002460:Cell Line; D018833:Chaperonins / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D006031:Glycosylation; D006056:Golgi Apparatus / Q000502:physiology / Q000821:virology; D006678:HIV / Q000187:drug effects / Q000502:physiology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017510:Protein Folding; D014759:Viral Envelope Proteins / Q000096:biosynthesis* / Q000737:chemistry / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects; D014780:Viruses / Q000187:drug effects*
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D014759:Viral Envelope Proteins; D018833:Chaperonins