title: Neoadjuvant chemoradiation for adenocarcinoma of the pancreas.
abstract: Pancreaticoduodenectomy is performed on carefully selected patients as part of a protocol-based clinical research program emphasizing the importance of multimodality management for patients with potentially resectable adenocarcinoma of the pancreatic head. Treatment schemas emphasize the importance of minimizing toxicity and treatment duration, while attempting to improve therapeutic efficacy. Cytotoxicity is enhanced by combining radiation therapy with more potent radiation-sensitizing agents. Because of the high incidence of liver metastases, systemic therapy is continued after chemoradiation and surgery with systemic agents of low toxicity directed at specific molecular events involved in pancreatic tumorigenesis such as inhibition of angiogenesis, induction of apoptosis, or arrest of the cell cycle.
authors.affiliation: Department of Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Miller
authors.forename: E K
authors.initials: EK
authors.lastname: Robinson
authors.forename: J E
authors.initials: JE
authors.lastname: Lee
authors.forename: P W
authors.initials: PW
authors.lastname: Pisters
authors.forename: P J
authors.initials: PJ
authors.lastname: Chiao
authors.forename: R L
authors.initials: RL
authors.lastname: Lenzi
authors.forename: J L
authors.initials: JL
authors.lastname: Abbruzzese
authors.forename: D B
authors.initials: DB
authors.lastname: Evans
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D006801:Humans; D010190:Pancreatic Neoplasms / Q000628:therapy*; D016577:Pancreaticoduodenectomy; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D018714:Radiotherapy, Adjuvant
chemical_list: D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents