Satigrel, a new antiplatelet agent, inhibits platelet accumulation in prosthetic arterial grafts.
BACKGROUND
Early and late vascular obstruction are both related to platelet adhesion and aggregation in the grafts. We assessed the effect of satigrel, a new oral antiplatelet agent, on the accumulation of indium-labeled platelets in knitted Dacron grafts inserted proximal to the femoral artery.


METHODS
Nine patients with arteriosclerosis obliterans receiving grafts were treated with satigrel, and 10 others were enrolled as untreated controls. Scintigraphy was performed in postoperative weeks 2 and 4, and the ratio of the scintillation count of the graft to that of the native artery was calculated to assess platelet accumulation.


RESULTS
In both weeks 2 and 4, the ratio was significantly smaller in the satigrel group than in the control group for the whole graft, the proximal anastomosis, and the distal anastomosis.


CONCLUSIONS
Satigrel significantly inhibited platelet accumulation in vascular grafts and thus may be useful for preventing postoperative graft occlusion.
Esato
K
K
First Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan.
Kubo
Y
Y
Yasuda
K
K
Shigematsu
H
H
Iwai
T
T
Ishimaru
S
S
Uchida
H
H
Ishii
K
K
D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000601:surgery; D001792:Blood Platelets; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D003627:Data Interpretation, Statistical; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D011093:Polyethylene Terephthalates; D011475:Prosthesis Failure; D011877:Radionuclide Imaging; D013997:Time Factors
D005229:Fatty Acids, Monounsaturated; D007205:Indium Radioisotopes; D010975:Platelet Aggregation Inhibitors; D011093:Polyethylene Terephthalates; C054678:Satigrel