title: [Endothelin-1 and its role in diabetes mellitus].
abstract: Endothelin-1 is mainly synthesised by the vascular endothelial cells and acts on the vascular smooth muscle. There are special endothelin receptors, endothelin receptor-A and endothelin receptor-B expressed on the vascular smooth muscle cells. Endothelin-1 through second messengers mobilises the intracellular calcium storage. The level of endothein-1 was found to be higher than normal in several diseases. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. The most severe and most frequent complications of diabetes mellitus are micro- and macroangiopathy. The authors summarise the physiological functions of endothelin-1 and its role in the development of diabetic angiopathy.
authors.affiliation: Semmelweis Orvostudományi Egyetem, II. sz. Belgyógyászati Klinika, Budapest.
authors.forename: B
authors.initials: B
authors.lastname: Sármán
authors.forename: M
authors.initials: M
authors.lastname: Tóth
authors.forename: A
authors.initials: A
authors.lastname: Somogyi
mesh_terms: D003925:Diabetic Angiopathies / Q000097:blood* / Q000378:metabolism; D019332:Endothelin-1 / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008934:Mitogens / Q000378:metabolism; D014662:Vasoconstrictor Agents / Q000378:metabolism
chemical_list: D019332:Endothelin-1; D008934:Mitogens; D014662:Vasoconstrictor Agents