title: A case of Epstein-Barr virus infection with exophthalmos and ocular muscle swelling.
abstract: A 14-year-old girl with Epstein-Barr virus (EBV) infection developed exophthalmos and ocular muscle swelling. The EBV genome was detected in T lymphocytes taken from the submandibular gland, temporal muscle and cervical lymph nodes. A surface marker analysis of her peripheral blood demonstrated that CD45RO-positive T lymphocytes were strongly activated. Immunosuppressive treatment, including steroid and cyclophosphamide, was effective in improving the symptoms. Immunosuppressive therapy may be included as the choice of treatment for EBV infection.
authors.affiliation: Department of Pediatrics, Mie University School of Medicine, Tsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sugiyama
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: R
authors.initials: R
authors.lastname: Ichimi
authors.forename: M
authors.initials: M
authors.lastname: Higashikawa
authors.forename: H
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Komada
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
authors.forename: H
authors.initials: H
authors.lastname: Wakiguchi
authors.forename: H
authors.initials: H
authors.lastname: Kikuta
authors.forename: M
authors.initials: M
authors.lastname: Fukayama
mesh_terms: D000293:Adolescent; D005094:Exophthalmos / Q000209:etiology*; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D009801:Oculomotor Muscles / Q000473:pathology*; D013601:T-Lymphocytes / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology