Calyxamines A and B, novel piperidine alkaloids from the Caribbean sea sponge Calyx podatypa.
Calyxamines A (1) and B (2) are 2,2,4,6,6-pentasubstituted piperidine alkaloids possessing novel carbon skeletons isolated from the marine sponge Calyx podatypa collected in Puerto Rico. Their structures, after derivatization with trifluoroacetic acid, have been determined by a combination of X-ray and spectroscopic methods. A plausible biogenetic pathway to the calyxamines is suggested.
Rodríguez
A D
AD
Department of Chemistry, University of Puerto Rico, Río Piedras 00931-3346, USA. abrodrig@upracd.upr.clu.edu
Cóbar
O M
OM
Padilla
O L
OL
Barnes
C L
CL
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*
D000470:Alkaloids; D010880:Piperidines; C110082:calyxamine A; C110083:calyxamine B