title: 5-HT1Dbeta receptor mediates the supersensitivity of isolated coronary artery to serotonin in variant angina.
abstract: Although serotonin (5-hydroxytryptamine; 5-HT) is used for provocation of coronary spasm, 5-HT receptor subtypes in spastic coronary arteries remain undetermined. We demonstrated the supersensitivity of isolated coronary artery to ergonovine, 5-HT, and sumatriptan, a 5-HT1D receptor agonist, in a patient with variant angina. Furthermore, we detected gene expression of 5-HT1Dbeta and 5-HT2A receptors in spastic coronary artery using RNase protection assay. These findings suggest that the leftward shift of the dose-response curve for 5-HT, which plays an important role in the pathogenesis of coronary spasm, is mediated by activation of 5-HT1Dbeta receptor.
authors.affiliation: First Department of Internal Medicine, Kobe University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: T
authors.initials: T
authors.lastname: Sakoda
authors.forename: K
authors.initials: K
authors.lastname: Kanazawa
authors.forename: S
authors.initials: S
authors.lastname: Kawashima
authors.forename: H
authors.initials: H
authors.lastname: Akita
authors.forename: M
authors.initials: M
authors.lastname: Yokoyama
mesh_terms: D000788:Angina Pectoris, Variant / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D003331:Coronary Vessels / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000378:metabolism; D004874:Ergonovine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D015870:Gene Expression; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects; D012333:RNA, Messenger / Q000096:biosynthesis; D044346:Receptor, Serotonin, 5-HT1D; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D012701:Serotonin / Q000008:administration & dosage / Q000009:adverse effects; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects; D018170:Sumatriptan / Q000008:administration & dosage / Q000009:adverse effects; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D010120:Oxytocics; D012333:RNA, Messenger; D044346:Receptor, Serotonin, 5-HT1D; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D018170:Sumatriptan; D004874:Ergonovine