title: Renal manifestations in angiotensinogen-deficient mice: unexpected phenotypes emerge.
abstract: The divergence between previously suggested RAS functions and unexpected phenotypes in RAS-related knockout mice may provide some hints about unknown functions of the RAS. One unsolved question is: does angiotensin II act directly as a growth factor for the renal cells via its specific receptors, or regulate some factor(s) responsible for renal cell growth? Advanced technology may help to answer this question and the others that will undoubtedly be raised.
authors.affiliation: Department of Pathology, University of Tsukuba, Japan. nagatam@md.tsukuba.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Nagata
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000808:Angiotensinogen / Q000172:deficiency* / Q000502:physiology; D000818:Animals; D005314:Embryonic and Fetal Development; D007674:Kidney Diseases / Q000209:etiology*; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype
chemical_list: D000808:Angiotensinogen