A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells.
The mechanisms of action of immunological adjuvants were studied using a system in which the behavior of adoptively transferred CD4+ T-cell receptor transgenic T-cells could be directly monitored following antigen administration. These studies revealed that adjuvant-induced inflammatory cytokines promote immunity by enhancing the clonal expansion, persistence and differentiation of antigen-activated CD4+ T-cells.
Pape
K A
KA
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA.
Jenkins
M K
MK
D000276:Adjuvants, Immunologic; D000818:Animals; D000941:Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation
D000276:Adjuvants, Immunologic; D000941:Antigens; D016207:Cytokines