Lack of H-2 gene influence on mouse susceptibility to secondary alveolar echinococcosis.
To determine whether the development of hepatic Echinococcus multilocularis infection is influenced by major histocompatibility-linked genes, metacestode growth and host immune responses were compared in 4 C57BL/10 congenic murine strains of H-2b, H-2d, H-2k and H-2q haplotypes. Although the H-2q strain appeared slightly more resistant than the other strains, the 4 strains of mice developed comparable spleen cell proliferative response and Th1/Th2 cytokine production at 13 weeks p.i. A kinetic analysis, performed in 2 of these congenic strains, showed a similar pattern of parasite growth in these mice and failed to detect any significant difference in the production of parasite-specific IgM, IgG1 and IgG2, antibodies. Consequently, this study indicates that the control of secondary alveolar echinococcosis is not H-2 gene-linked.
Emery
I
I
Laboratoire de Parasitologie, Faculté de Médecine, Créteil, France.
Leclerc
C
C
Houin
R
R
Vuitton
D A
DA
Liance
M
M
D000818:Animals; D004198:Disease Susceptibility; D004445:Echinococcosis, Pulmonary / Q000276:immunology*; D004446:Echinococcus / Q000254:growth & development; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D007109:Immunity; D007132:Immunoglobulin Isotypes / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D011650:Pulmonary Alveoli / Q000469:parasitology*; D013601:T-Lymphocytes / Q000276:immunology
D006183:H-2 Antigens; D007132:Immunoglobulin Isotypes