Involvement of lipid peroxidation in platelet signalling.
A well-known signalling pathway in blood platelets consists in the release of arachidonic acid (AA) from membrane phospholipids and its specific oxygenation into bioactive derivatives. In particular, cyclic prostaglandin endoperoxides and thromboxane A2 are potent inducers of platelet functions and are produced in greater amounts when the level of lipid hydroperoxides is higher than normal, as 'physiological concentrations' of such peroxides activate the cyclooxygenation of AA. In this context, a lower activity of platelet glutathione peroxidase (GPx), the key-enzyme for the degradation of lipid hydroperoxides, has been reported in aging, which will ensure a longer life span to those peroxides. Accordingly, the biosynthesis of pro-aggregatory prostanoids is elevated in platelets from the elderly. On the other hand, fatty acids from marine origin have been recognized as inhibitors of platelet functions, and they may alter the redox status of cells. They may for instance increase the platelet GPx activity, an effect that can be prevented by antioxidants. Overall, these data point out the relevance of the redox status in platelet functions.
Lagarde
M
M
INSERM U352, Biochimie et Pharmacologie INSA-Lyon, Villeurbanne, France.
Lemaitre
D
D
Calzada
C
C
Véricel
E
E
D000368:Aged; D001095:Arachidonic Acids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D010084:Oxidation-Reduction; D015539:Platelet Activation / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated