Bone mineral density in children with asthma receiving long-term treatment with inhaled budesonide.
The aim of our study was to assess the effects of long-term treatment with inhaled budesonide (BUD) on total body bone mineral density (BMD), total body bone mineral capacity (BMC), total bone calcium (TBC), and body composition in children with asthma. Dual energy X-ray absorptiometry (DEXA scan) was performed in 157 asthmatic children treated with inhaled BUD at a mean daily dose of 504 microg (range, 189 to 1,322 microg) for 3 to 6 yr (mean, 4.5 yr). Measurements were compared with those of 111 age-matched children also suffering from asthma but who had never been treated with exogenous corticosteroids for more than 14 d (control group). There were no statistically significant differences between the two groups in BMD (BUD = 0.915 g/cm2, controls = 0.917 g/cm2), BMC (BUD = 1,378 g, controls = 1,367 g), TBC (BUD = 524 g, controls = 519 g), or body composition (lean body weight = 27,600 g [BUD] and 26,923 g [control], % body fat = 20.1% [BUD] and 20.3% [control]). Furthermore, there was no correlation between any of these parameters and duration of treatment, accumulated or current dose of budesonide. Three to six years of treatment with inhaled budesonide at an average daily dose of 504 microg has no adverse effect on total BMD, total BMC, TBC, or body composition in children with chronic asthma.
Agertoft
L
L
Department of Pediatrics, Kolding Hospital, Denmark.
Pedersen
S
S
D015502:Absorptiometry, Photon; D000280:Administration, Inhalation; D000293:Adolescent; D001249:Asthma / Q000188:drug therapy*; D001823:Body Composition; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000737:chemistry; D001993:Bronchodilator Agents / Q000009:adverse effects*; D019819:Budesonide / Q000009:adverse effects*; D002118:Calcium / Q000032:analysis; D002648:Child; D003430:Cross-Sectional Studies; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013997:Time Factors
D001993:Bronchodilator Agents; D019819:Budesonide; D002118:Calcium