The use of transgenic animals to assess the role of metabolism in target organ toxicity.
Wolf
C R
CR
Imperial Cancer Research Fund Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, UK.
Campbell
S J
SJ
Clark
A J
AJ
Smith
A
A
Bishop
J O
JO
Henderson
C J
CJ
D000818:Animals; D030801:Animals, Genetically Modified; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D012867:Skin / Q000187:drug effects / Q000201:enzymology; D015262:Xenobiotics / Q000378:metabolism / Q000633:toxicity*
D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase