title: Apolipoprotein(a) gene enhancer resides within a LINE element.
abstract: Apolipoprotein(a), (apo(a)), is the distinguishing protein portion of the lipoprotein(a) particle, elevated plasma levels of which are a major risk factor for cardiovascular disease. A search for enhancer elements that control the transcription of the apo(a) gene led to the identification of an upstream element that contains target binding sites for members of the Ets and Sp1 nuclear protein families. The enhancer element functions in either orientation to confer a greater than 10-fold increase in the activity of the apo(a) minimal promoter in cultured hepatocyte cells. Unexpectedly, the enhancer element is located within a LINE retrotransposon element, suggesting that LINE elements may function as mobile regulatory elements to control the expression of nearby genes.
authors.affiliation: Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, California 94305-5246, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: Boffelli
authors.forename: N
authors.initials: N
authors.lastname: Boonmark
authors.forename: K
authors.initials: K
authors.lastname: Schwartz
authors.forename: R
authors.initials: R
authors.lastname: Lawn
mesh_terms: D001053:Apolipoproteins / Q000235:genetics*; D053241:Apoprotein(a); D001483:Base Sequence; D004247:DNA; D004742:Enhancer Elements, Genetic; D006801:Humans; D017270:Lipoprotein(a); D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D017384:Sequence Deletion; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
chemical_list: D001053:Apolipoproteins; D017270:Lipoprotein(a); D004247:DNA; D053241:Apoprotein(a)