title: Comparison of sib-pair and variance-components methods for genomic screening.
abstract: The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance-components method had better power for detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods.
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland 21224, USA.
authors.forename: E W
authors.initials: EW
authors.lastname: Pugh
authors.forename: C E
authors.initials: CE
authors.lastname: Jaquish
authors.forename: A J
authors.initials: AJ
authors.lastname: Sorant
authors.forename: J P
authors.initials: JP
authors.lastname: Doetsch
authors.forename: J E
authors.initials: JE
authors.lastname: Bailey-Wilson
authors.forename: A F
authors.initials: AF
authors.lastname: Wilson
mesh_terms: D000704:Analysis of Variance; D001331:Automation; D002874:Chromosome Mapping; D005260:Female; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D009679:Nuclear Family; D010641:Phenotype; D011237:Predictive Value of Tests
chemical_list: D005819:Genetic Markers