title: Expectant management as an option for men with stage T1c prostate cancer: a preliminary study.
abstract: The outcome of patients selecting observation of clinical stage T1c prostate cancer is unknown. A total of 101 men with clinical stage T1c prostate cancer were evaluated, counseled, and monitored in a standard fashion. Altogether, 27 men who elected observation were older and had greater co-morbidity but similar tumor characteristics as compared with 74 men who elected radical prostatectomy. In all, 9 men demonstrated clinical or biochemical evidence of progression after a mean follow-up of 23 months; 4 men who underwent radical prostatectomy had specimen-confined disease and undetectable post-operative levels of PSA. Observation appears to be a viable option for some men with clinical stage T1c prostate cancer.
authors.affiliation: Department of Surgery, University of North Carolina Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Mohler
authors.forename: B T
authors.initials: BT
authors.lastname: Williams
authors.forename: J A
authors.initials: JA
authors.lastname: Freeman
mesh_terms: D000368:Aged; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000032:analysis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D016019:Survival Analysis
chemical_list: D017430:Prostate-Specific Antigen