Age-related mitochondrial DNA deletions: effect of dietary restriction.
Results from quantitative PCR analysis of the frequency of deleted mitochondrial genomes in male Fischer 344 rats reveal an age-related rise in this molecular abnormality. We used this model to examine the ability of dietary restriction (DR) to prevent this potentially pathogenic change. DR prevented age-related increase in frequency of mitochondrial deletions in the liver. In contrast, however, DR had no effect on the age-related increase in deletion frequency in the brain. These data suggest that the effects of DR on age-related accumulation of mitochondrial DNA deletions may be tissue specific.
Kang
C M
CM
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756, USA.
Kristal
B S
BS
Yu
B P
BP
D000375:Aging / Q000235:genetics*; D000818:Animals; D002872:Chromosome Deletion; D004272:DNA, Mitochondrial / Q000235:genetics*; D002149:Energy Intake; D016678:Genome; D008297:Male; D016133:Polymerase Chain Reaction; D051381:Rats; D011916:Rats, Inbred F344
D004272:DNA, Mitochondrial