Biochemical alterations in neonatal hypoxic ischaemic brain damage.
Asphyxiated (n = 39) and control (n = 23) were elected for the study. Free radical-mediated lipid peroxidation, prostaglandin E2 and vitamin E levels were studied and the degree of hypoxic ischaemic encephalopathy was determined in each case. In the hypoxic group the concentration of prostaglandin E2 activity (P < 0.05) and malondialdehyde levels (P < 0.01) were significantly higher when compared to that of controls. The high vitamin E concentrations in the asphyxiated infants supports the role of oxygen free radicals in hypoxic ischaemic encephalopathy of newborns.
Gücüyener
K
K
Gazi University Medical Faculty, Department of Pediatric Neurology, Ankara, Turkey.
Gür
T
T
Oz
E
E
Türkyilmaz
C
C
Oztürk
G
G
Erbaş
D
D
Atalay
Y
Y
Hasanoğlu
A
A
D001238:Asphyxia Neonatorum / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D015232:Dinoprostone / Q000097:blood / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000378:metabolism*; D014810:Vitamin E / Q000097:blood / Q000378:metabolism*
D014810:Vitamin E; D008315:Malondialdehyde; D015232:Dinoprostone