Detecting gene-environment interactions using a case-control design.
We assessed the sample size required for detecting gene-environment (G x E) interactions in a case-control study of complex diseases. The results suggest that large numbers of cases and controls will be required to detect G x E interaction for some odds ratio and exposure frequency combinations. These and other results suggest that alternative study designs may be needed to detect G x E interaction particularly with rare genes or uncommon environmental exposures.
Goldstein
A M
AM
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Falk
R T
RT
Korczak
J F
JF
Lubin
J H
JH
D016022:Case-Control Studies; D004777:Environment; D005787:Gene Frequency; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D012307:Risk Factors; D018401:Sample Size