title: High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission.
abstract: OBJECTIVE
  The role for high-dose therapy and autologous stem-cell transplantation in mantle-cell lymphoma (MCL) is unknown. We retrospectively analyzed patients with chemosensitive disease who underwent high-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation (ABMT) for MCL in first remission, as well as following relapse from conventional therapy.
  
  
  METHODS
  Between August 1985 and April 1996, 28 patients underwent ABMT using a uniform ablative regimen with cyclophosphamide and total-body irradiation (TBI) and a bone marrow-purging regimen. Re-review of original tissue demonstrated that all patients had morphologic, phenotypic, and genotypic characteristics of MCL. MCL was the original diagnosis in 21 patients, whereas seven patients had a prior diagnosis of diffuse small cleaved-cell lymphoma.
  
  
  RESULTS
  Twenty patients received multiple regimens before ABMT, while eight underwent ABMT in first complete remission (CR)/partial remission (PR) following CHOP induction. At bone marrow harvest, only 18% of patients were in CR and overt BM infiltration was present in 57%. Following cyclophosphamide/TBI, no treatment-related deaths were seen. Nineteen of 28 patients have relapsed at a median time of 21 months (range, 3 to 70). Of eight patients transplanted in first CR/PR, five have relapsed. Nine patients are in continuous CR with a median follow-up time of 24 months (range, 10 to 135). Disease-free survival (DFS) and overall survival (OS) are estimated to be 31% and 62% at 4 years, respectively.
  
  
  CONCLUSIONS
  ABMT using cyclophosphamide/TBI conditioning may at best be effective in only a small fraction of patients with relapsed MCL. The lack of plateau with a median follow-up time of 24 months suggests cure may not be achievable. The role of this therapy in patients in first remission requires more study using better induction therapy to enhance the CR rate before ABMT.
authors.affiliation: Division of Hematologic Malignancies and Biostatistics, Dana-Farber Cancer Institute, Boston, MA 02115, USA. arney-freedman@dfci.harvard.edu
authors.forename: A S
authors.initials: AS
authors.lastname: Freedman
authors.forename: D
authors.initials: D
authors.lastname: Neuberg
authors.forename: J G
authors.initials: JG
authors.lastname: Gribben
authors.forename: P
authors.initials: P
authors.lastname: Mauch
authors.forename: R J
authors.initials: RJ
authors.lastname: Soiffer
authors.forename: D C
authors.initials: DC
authors.lastname: Fisher
authors.forename: K C
authors.initials: KC
authors.lastname: Anderson
authors.forename: N
authors.initials: N
authors.lastname: Andersen
authors.forename: R
authors.initials: R
authors.lastname: Schlossman
authors.forename: M
authors.initials: M
authors.lastname: Kroon
authors.forename: J
authors.initials: J
authors.lastname: Ritz
authors.forename: J
authors.initials: J
authors.lastname: Aster
authors.forename: L M
authors.initials: LM
authors.lastname: Nadler
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000276:immunology*; D016465:Bone Marrow Purging / Q000379:methods*; D016026:Bone Marrow Transplantation / Q000379:methods*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone