title: Production of brominated tiacumicin derivatives
abstract: Several novel tiacumicin derivatives containing bromine have been produced by the addition of inorganic bromine to the fermentation broth of Dactylosporangium aurantiacum subsp. hamdenesis. Structures were elucidated employing mass spectrometry and NMR spectroscopy. Antibacterial activity of the bromotiacumicins is comparable to that of the parent compounds.
authors.affiliation: Pharmaceutical Products Research and Development Abbott Laboratories, Abbott Park, Illinois 60064, USA.
authors.initials: JE
authors.lastname: Hochlowski
authors.initials: M
authors.lastname: Jackson
authors.initials: RR
authors.lastname: Rasmussen
authors.initials: AM
authors.lastname: Buko
authors.initials: JJ
authors.lastname: Clement
authors.initials: DN
authors.lastname: Whittern
authors.initials: JB
authors.lastname: McAlpine