title: Relation of exploratory behavior of rats in elevated plus-maze to brain receptor binding properties and serum growth hormone levels.
abstract: Forty-five male Wistar rats were selected according to their behavior in the elevated plus-maze. They were separated as follows: animals with low exploratory activity ('anxious'), an 'intermediate' group and animals having high exploratory activity ('non-anxious'). Various receptor binding studies and hormonal assays were also performed in these selected rats. The affinity of 5-hydroxytryptamine 5-HT2A receptors in the frontal cortex was lower in the 'anxious' rats compared to home-cage controls and 'non-anxious' animals. Moreover, the number of cholecystokinin (CCK) receptors in the hippocampus was significantly elevated in the 'anxious' group compared to home-cage control animals. The blood levels of growth hormone (GH) were significantly lower in the 'non-anxious' rats compared to 'anxious' counterparts. In conclusion, it seems likely that the decreased exploratory activity of rats is related to the increased 5-hydroxytryptamine (5-HT) and CCK mediated neurotransmission in the brain. The different serum levels of GH in the selected rats probably reflect alterations in the activity of 5-HT and CCK.
authors.affiliation: Department of Physiology, University of Tartu, Estonia. sulev.koks@ut.ee
authors.forename: S
authors.initials: S
authors.lastname: Kõks
authors.forename: E
authors.initials: E
authors.lastname: Vasar
authors.forename: A
authors.initials: A
authors.lastname: Soosaar
authors.forename: A
authors.initials: A
authors.lastname: Lang
authors.forename: V
authors.initials: V
authors.lastname: Volke
authors.forename: V
authors.initials: V
authors.lastname: Võikar
authors.forename: M
authors.initials: M
authors.lastname: Bourin
authors.forename: P T
authors.initials: PT
authors.lastname: Männistö
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology*; D005625:Frontal Lobe / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D017072:Neostriatum / Q000378:metabolism; D010907:Pituitary Hormones / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*
chemical_list: D010907:Pituitary Hormones; D011949:Receptors, Cholecystokinin; D017448:Receptors, Dopamine D2; D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; D013006:Growth Hormone