A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension.
BACKGROUND
A mutation in the gene for the angiotensin II type 1 (AT1) receptor (A1166C) has been reported to be associated with primary hypertension.


OBJECTIVE
To determine whether this observation could be confirmed with a different population sample.


METHODS
We examined 414 individuals with primary hypertension and 172 normotensive controls.


METHODS
The mutation in the gene for the AT1 receptor was detected using restriction polymerase chain reaction.


CONCLUSIONS
We detected no association of the AT1 receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the 1166C allele among hypertensive patients with a late age at diagnosis (> or = 50 years) was observed.
Schmidt
S
S
Department of Internal Medicine, University of Heidelberg, Germany.
Beige
J
J
Walla-Friedel
M
M
Michel
M C
MC
Sharma
A M
AM
Ritz
E
E
D000328:Adult; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000502:physiology*; D011945:Receptors, Angiotensin / Q000235:genetics*; D012016:Reference Values
D011945:Receptors, Angiotensin