Therapeutic effects of water-soluble echinocandin compounds on Pneumocystis pneumonia in mice.
The therapeutic effectiveness of water-soluble echinocandin compounds obtained from Coleophoma empetri F-11899, which has a strong inhibitory effect on the growth of fungi, was examined in nude mice with experimental Pneumocystis pneumonia. The studies demonstrated the potential usefulness of the compounds.
Furuta
T
T
Department of Parasitology, The Institute of Medical Science, The University of Tokyo, Japan. furuta@hgc.ims.u-tokyo.ac.jp
Muramatsu
H
H
Fujie
A
A
Fujihira
S
S
Abudullah
N R
NR
Kojima
S
S
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry / Q000627:therapeutic use*; D011010:Pneumocystis / Q000187:drug effects* / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D051381:Rats
C110369:FR 131535; C110368:FR 901379; D010456:Peptides, Cyclic