The daughters of diethylstilbestrol. Lessons from an error.
Diethylstilbestrol (DES) has been used extensively to prevent pregnancy disorders in Europe but at different levels depending upon the countries. Lessons from the DES story can be learned for research, information for physicians, communication, administration and industry. However, this paper will focus on the incidence of this story in our practice. We will propose guidelines for different conditions: clear cell adenocarcinoma, adenosis, cervical dysplasia, infertility and pregnancy.
Tournaire
M
M
Department of Gynecology and Obstetrics, Hôpital Saint Vincent de Paul, Paris, France.
Lepercq
J
J
Epelboin
S
S
D018262:Adenocarcinoma, Clear Cell / Q000139:chemically induced / Q000517:prevention & control; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004345:Drug Industry; D005260:Female; D006801:Humans; D010819:Physician's Role; D011247:Pregnancy; D002577:Uterine Cervical Diseases / Q000139:chemically induced / Q000517:prevention & control; D014623:Vaginal Diseases / Q000139:chemically induced / Q000517:prevention & control
D004054:Diethylstilbestrol