Outcome of coronary bypass surgery versus coronary angioplasty in diabetic patients with multivessel coronary artery disease.
OBJECTIVE
This study sought to compare the outcome of percutaneous transluminal coronary angioplasty (PTCA) (n = 834) and coronary artery bypass graft surgery (CABG) (n = 1805) in diabetic patients with multivessel coronary disease from an observational database.


BACKGROUND
There is concern about selection of revascularization in diabetic patients with multivessel coronary artery disease.


METHODS
Data were collected prospectively and entered into a computerized database. Follow-up was by letter or telephone or additional events resulting in readmission.


RESULTS
After CABG there were more in-hospital deaths (0.36% vs. 4.99%, p < 0.0001) and a trend toward more Q wave myocardial infarctions than after PTCA. Five- and 10-year survival rates were 78% and 45% after PTCA and 76% and 48% after CABG, respectively (p = 0.47). At 5 and 10 years, insulin-requiring patients had lower survival rates of 72% and 31% after PTCA and 70% and 48% after CABG, respectively (p = 0.54). Multivariate correlates of long-term mortality were older age, low left ventricular ejection fraction, heart failure and hypertension. In the total group, insulin requirement was a correlate of long-term mortality. For the total group, choice of therapy had a multivariate hazard ratio close to 1. In the insulin-requiring subgroup, the multivariate hazard ratio was 1.35 (95% confidence interval 1.01 to 1.79) for PTCA versus CABG. Corrected for baseline differences, 5- and 10-year survival rates were 68% and 36% after PTCA and 75% and 47% after CABG, respectively, in the insulin-requiring subgroup. Nonfatal events were more common after PTCA, especially additional revascularization.


CONCLUSIONS
This study reveals a high incidence of events in diabetic patients and raises further questions about angioplasty in insulin-requiring diabetic patients with multivessel disease.
Weintraub
W S
WS
Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. bill@hp3.eushc.org
Stein
B
B
Kosinski
A
A
Douglas
J S
JS
Ghazzal
Z M
ZM
Jones
E L
EL
Morris
D C
DC
Guyton
R A
RA
Craver
J M
JM
King
S B
SB
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome