title: Genomic evolution of the distal Mhc class I region on mouse Chr 17.
abstract: A 5-Mb YAC contig, partly supplemented with BAC contigs, was created from the distal Mhc class I region on mouse Chr 17. The gene order of Znf173-Tctex5-Mog-D17Tu42-D17Leh 89 is conserved between mouse and human but not the physical distance, supporting the independent expansion of Mhc class I genes in the so-called accordion model of Mhc evolution. The distal H2-M region includes the breakpoint of conserved synteny between mouse and human as well as the In(17)4 t-inversion. The H2-M region is rich in L1 repeats, implying that the insertion of L1 repeats may be associated with the evolutionary flexibility to break a chromosome.
authors.affiliation: Howard Hughes Medical Institute, Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas 75235-9050, USA.
authors.forename: M
authors.initials: M
authors.lastname: Yoshino
authors.forename: H
authors.initials: H
authors.lastname: Xiao
authors.forename: E P
authors.initials: EP
authors.lastname: Jones
authors.forename: A
authors.initials: A
authors.lastname: Kumánovics
authors.forename: C
authors.initials: C
authors.lastname: Amadou
authors.forename: K
authors.initials: K
authors.lastname: Fischer Lindahl
mesh_terms: D000818:Animals; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D019143:Evolution, Molecular; D005805:Genes, MHC Class I; D006801:Humans; D051379:Mice / Q000235:genetics*; D008957:Models, Genetic; D005810:Multigene Family; D013045:Species Specificity