title: No difference in blood thiamine diphosphate levels between Swedish Caucasian patients with congestive heart failure treated with furosemide and patients without heart failure.
abstract: OBJECTIVE
  To determine whether furosemide treatment in congestive heart failure (CHF) patients is associated with thiamine deficiency.
  
  
  METHODS
  Patients without heart failure and without diuretic treatment were included to compare with patients with CHF belonging to New York Heart Association (NYHA) functional class II and III-IV, respectively, and receiving furosemide therapy.
  
  
  METHODS
  All patients were recruited from the emergency ward of the cardiology section. Huddinge University Hospital, where they were admitted due to CHF or acute myocardial infarction.
  
  
  METHODS
  Ninety-nine patients were included from whom a blood sample was taken, as well as routine admission blood samples for the analysis of thiamine diphosphate (TPP) concentrations. Patients taking vitamin preparations were excluded.
  
  
  METHODS
  Blood TPP concentrations were measured by high performance liquid chromatography (HPLC) and compared between the patient groups by the use of ANOVA.
  
  
  RESULTS
  No significant difference was found between the groups in blood TPP concentrations.
  
  
  CONCLUSIONS
  Thiamine deficiency may not be a complication of furosemide treatment in the studied Swedish patient population.
authors.affiliation: Department of Clinical Pharmacology, Huddinge University Hospital, Sweden.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Yue
authors.forename: B
authors.initials: B
authors.lastname: Beermann
authors.forename: B
authors.initials: B
authors.lastname: Lindström
authors.forename: O
authors.initials: O
authors.lastname: Nyquist
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002851:Chromatography, High Pressure Liquid; D004232:Diuretics / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005665:Furosemide / Q000009:adverse effects* / Q000627:therapeutic use; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013548:Sweden; D013835:Thiamine Pyrophosphate / Q000097:blood* / Q000172:deficiency; D044465:White People
chemical_list: D004232:Diuretics; D005665:Furosemide; D013835:Thiamine Pyrophosphate