The medical utility of genomics data in neuropsychiatry: mutational genetics versus association genetics.
The long anticipated 'genetic revolution' in neuropsychiatry has yet to have an impact on the practice of clinical medicine. Excitement in the 1980s over major genetic breakthroughs in schizophrenia and manic depression, for example, has been replaced in the late 1990s by the sobering realization that most common neuropsychiatric disorders are multifactorial. Despite considerable effort and resources, no 'causative' genetic variation has been identified that plays a definitive major role in any common neuropsychiatric disorder.
Peroutka
S J
SJ
Spectra Biomedical, Inc., Bullingame, CA 94010, USA. DrPeroutka@aol.com
D001689:Biological Psychiatry; D003131:Combined Modality Therapy; D016678:Genome; D006801:Humans; D001523:Mental Disorders / Q000235:genetics* / Q000628:therapy; D009154:Mutation; D010641:Phenotype