title: Insulinoma in a patient with non-insulin-dependent diabetes mellitus.
abstract: Insulinoma in a patient with pre-existing diabetes is exceedingly rare. Only a small number of well-documented cases have been reported in the world during the last 40 years. We describe a case with non-insulin-dependent diabetes mellitus who after seven years of sulfonylurea treatment experienced recurrent episodes of hypoglycemia. Endogenous hyperinsulinism was found and radiographical examination and transhepatic venous sampling confirmed an insulin secreting pancreatic tumor. After surgical excision of the tumor, patient was relieved from hypoglycemic attacks but required to initiate insulin injection for the treatment of hyperglycemia.
authors.affiliation: Department of Geriatrics, Endocrinology and Metabolism, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Sakurai
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: M
authors.initials: M
authors.lastname: Katakura
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: G
authors.initials: G
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Yoshizawa
authors.forename: K
authors.initials: K
authors.lastname: Hashizume
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007340:Insulinoma / Q000150:complications / Q000503:physiopathology*; D008297:Male; D010190:Pancreatic Neoplasms / Q000150:complications / Q000503:physiopathology*; D012636:Secretory Rate
chemical_list: D007328:Insulin