[Expression of adhesion molecules and costimulatory molecules in inflammatory myopathies].
To clarify the local immune responses in inflammatory myopathies, we examine recent studies on expression of adhesion and costimulatory molecules. Adhesion molecules participate in MNC influx from blood vessels into muscle tissues and interactions of inflamed muscle cells with surrounded MNC. These antigens may work as costimulatory molecules in antigen presenting process by muscle cells, as well as in augmentation of inflammation by infiltrating MNCs.
Murakawa
Y
Y
Third Division, Department of Internal Medicine, Shimane Medical University.
Sugiura
T
T
Kobayashi
S
S
D017951:Antigen Presentation; D015703:Antigens, CD / Q000378:metabolism / Q000502:physiology; D018122:B7-1 Antigen / Q000378:metabolism / Q000502:physiology; D051940:B7-2 Antigen; D001808:Blood Vessels; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002465:Cell Movement; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D009132:Muscles / Q000276:immunology / Q000378:metabolism; D009220:Myositis / Q000276:immunology*; D015398:Signal Transduction; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1