Modification of cesium toxicity by calcium in mammalian system.
The interaction between cesium chloride CsCl and calcium chloride CaCl2 was observed in bone marrow chromosomes of mice. The two salts were administered orally to laboratory bred Swiss albino mice in vivo singly or one followed by the other, or both simultaneously. CsCl induced chromosomal aberrations in frequencies directly proportional to the dose administered. The frequency of aberrations was reduced significantly when the two chemicals were administered simultaneously or when CaCl2 was given 2 h before CsCl. Thus, CaCl2 is able to protect against the cytotoxicity of CsCl.
Ghosh
A
A
Genetic Toxicology Unit, University of Calcutta, India.
Ghosh
A K
AK
Sharma
A
A
Talukder
G
G
D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000648:ultrastructure; D002122:Calcium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D002586:Cesium / Q000008:administration & dosage / Q000633:toxicity*; D002712:Chlorides / Q000008:administration & dosage; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D051379:Mice
D002712:Chlorides; D002586:Cesium; C028019:cesium chloride; D002122:Calcium Chloride