Increased number of peripheral blood CD34+ cells in lithium-treated patients.
Eight adult patients with bipolar disorder were prospectively examined to find whether lithium carbonate increased their peripheral blood CD34+ haemopoietic stem cells. Following lithium therapy for 3-4 weeks their neutrophil counts increased by a mean of 88% (from 4625 +/- 1350 x 10(9)/l, mean +/- SD pretreatment, to a peak of 8300 +/- 3910 x 10(9)/l). Concommitantly, there was a significant increment in their CD34+ cells (from 0.11 +/- 0.01% to a peak of 0.18 +/- 0.08%). There was a significant correlation between the rise in neutrophil count and that of the CD34+ cells (r = 0.795, P = 0.019). Lithium therapy may be used to mobilize peripheral blood CD34+ cells for marrow transplantation.
Ballin
A
A
Department of Haematology, The E. Wolfson Medical Centre, Holon, Israel.
Lehman
D
D
Sirota
P
P
Litvinjuk
U
U
Meytes
D
D
D000328:Adult; D018952:Antigens, CD34; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007964:Leukocytosis / Q000139:chemically induced; D016651:Lithium Carbonate / Q000627:therapeutic use*; D009504:Neutrophils / Q000187:drug effects; D011446:Prospective Studies
D018952:Antigens, CD34; D016651:Lithium Carbonate