Can blood group O red cells of donor origin acquire weak group A reactivity through serum A transferase of the recipient after bone marrow transplantation?
Blood group A substance was detected on red cells of a patient who had received a bone marrow transplant from a blood group 0 donor 3 1/2 years ago. All peripheral blood cells are of donor origin. Anti-A but not anti-A,B of blood group 0 individuals can be absorbed to the group 0 red cells of the patient. We suppose that the patient's residual serum A transferase attaches the appropriate sugar to H substance on the red cell membrane to form A substance.
Wichmann
M G
MG
Institut für Transfusionsmedizin, Universität Kiel, Germany.
Haferlach
T
T
Suttorp
M
M
Zhang
Y
Y
Neppert
J
J
D000017:ABO Blood-Group System / Q000235:genetics; D016026:Bone Marrow Transplantation; D005260:Female; D005500:Follow-Up Studies; D006386:Hemagglutination Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D017350:N-Acetylgalactosaminyltransferases / Q000378:metabolism*
D000017:ABO Blood-Group System; D017350:N-Acetylgalactosaminyltransferases; C003742:UDPgalactosamine-galactose acetylgalactosaminyltransferase