[Relationships between selenium deficiency and 3,5,3'-triiodothyronine (T3) synthesis].
Several enzymes, the main being type I 5' deiodinase, ensure thyroxin (T4) into 3,5,3'-triiodothyronine (T3) deiodination, both in the thyroid and in peripheral tissues. One of the feature of this enzymatic reaction is its regulation. It depends in part on individual selenium and iodine status. It has been shown by an analysis of thyroid hormones concentrations variations, when one of these trace elements is missing. During thyroid hormone synthesis, selenium and iodine are also implied in oxidative process control. Then, how selenium and iodine status balance modifications contribute to thyroidal diseases outbreak, becomes easier to understand. Besides, providing, adapted to individual requirements, selenium and iodine supplies could be useful for hypothyroidism and hyperthyroidism treatment.
Bouvier
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Laboratoire de Pharmacologie, C.H.U., Reims.
Millart
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D000818:Animals; D006801:Humans; D007455:Iodine / Q000172:deficiency / Q000494:pharmacology / Q000627:therapeutic use; D012643:Selenium / Q000172:deficiency* / Q000494:pharmacology / Q000627:therapeutic use; D013959:Thyroid Diseases / Q000188:drug therapy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000096:biosynthesis*
D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D012643:Selenium; D013974:Thyroxine