T cell repertoire: genomic or somatic bias toward recognition of major histocompatibility complex molecules?
The prevailing concept about a major influence of thymic positive selection on shaping the T cell repertoire during ontogeny is confronted with an old idea emphasizing a dominant role for genetic (evolutionary) factors in molding the recognition potential of mature T cells. Our recent results are not readily interpreted without introducing a new version of the old concept, according to which complementarity to the major histocompatibility complex peptide-binding site is a major evolutionary selective pressure on T cell antigen receptor variable genes, with alloreactivity being a reflection of this fact.
Vidović
D
D
Department of Immunology, Hoffmann-La Roche, Inc., Nutley, NJ 07110-1199, USA.
Boulanger
N
N
Guenot
J
J
Nagy
Z A
ZA
D000818:Animals; D017951:Antigen Presentation; D017637:Clonal Deletion; D003433:Crosses, Genetic; D019281:Dimerization; D015329:Gene Rearrangement, T-Lymphocyte; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D007519:Isoantigens / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008957:Models, Genetic; D018448:Models, Immunological; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen; D007519:Isoantigens; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta