Hematopoietic changes in rats after inescapable and escapable shocks.
Bone marrow cell responsiveness to hematopoietic growth factors was investigated in rats only confined or experiencing inescapable, escapable shocks or no electric shock. The results demonstrated a significant reduction in the number of granulocyte-macrophage precursors in the bone marrow of confined rats and of rats exposed to inescapable shocks. The reversibility of this mielossupressive response was seen in both groups and occurred first in the confined animals. No changes were observed in the group submitted to escapable shocks when compared to controls.
Malacrida
S A
SA
Department of Pharmacology and Hemocentre, Faculty of Medical Sciences, State University of Campinas, SP, Brazil.
Teixeira
N A
NA
Queiroz
M L
ML
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D004597:Electroshock; D005260:Female; D006098:Granulocytes / Q000166:cytology; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D008264:Macrophages / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology
D016298:Hematopoietic Cell Growth Factors