Catecholamine neurons alteration in the brainstem of sudden infant death syndrome victims.
BACKGROUND
Sudden infant death syndrome (SIDS) is a leading cause of postneonatal infant death. The pathogenesis of sudden death is still unknown, but an abnormality in the central nervous regulation of breathing during sleep has been suggested.


OBJECTIVE
The aim of study is to confirm the brainstem disorder of SIDS victims. In order to do this, it is necessary to investigate the alterations of brain neurotransmitter systems thought to be involved in respiratory control.


METHODS
Neuropathologic study performed on the brainstem of SIDS victims.


METHODS
The disorders of catecholaminergic systems in 22 SIDS victims were examined on the substantia nigra in the midbrain, locus coeruleus in the pons, vagal nuclei, and area reticularis superficialis ventrolateralis with the immunohistochemical method. Immunoperoxidase staining was performed with the antityrosine hydroxylase (TH) and the glial fibrillary acidic protein antibodies. Immunoreactivity was compared with 13 age-matched control infants. For statistical analysis, the chi 2 test and the Student's t test were performed.


RESULTS
The main finding was diminished TH immunoreactivity in the vagal nuclei and area reticularis superficialis ventrolateralis of SIDS victims, suggesting that adrenaline and noradrenaline neurons are altered in SIDS. In addition, this decrease in TH was closely correlated with brainstem gliosis.


CONCLUSIONS
These catecholaminergic changes may be caused by chronic hypoxia or ischemia, and also may underlie alterations in respiratory and cardiovascular control in sleep.
Obonai
T
T
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Yasuhara
M
M
Nakamura
T
T
Takashima
S
S
D001933:Brain Stem / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D002395:Catecholamines / Q000032:analysis*; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D007124:Immunoenzyme Techniques; D007223:Infant; D008125:Locus Coeruleus / Q000737:chemistry / Q000276:immunology; D009474:Neurons / Q000737:chemistry* / Q000276:immunology; D013378:Substantia Nigra / Q000737:chemistry / Q000276:immunology; D013398:Sudden Infant Death / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology
D002395:Catecholamines; D005904:Glial Fibrillary Acidic Protein; D007106:Immune Sera; D014446:Tyrosine 3-Monooxygenase