[Distribution of 3H-labeled acetyl-HEMA monomer in rats].
Original method of tritiation of acetyl-HEMA and its hydrogenated product was developed. Distribution and excretion of both compounds was examined in rat for up to 70 hrs. While the distribution in the tissues examined (liver, spleen, kidney, lung, muscle, heart, and skin) was nearly uniform, the excretion of acetyl-HEMA and its hydrogenated form differed: acetyl-HEMA in the 24. hour is excreted preferably into urine, the hydrogenated form in faeces. In addition to it the later form was absorbed from the application point (muscle) more rapidly. Distinct cumulation of activity (original compound or/and its metabolites) was observed in all tissues.
Prokes
J
J
Ustav pro toxikologii a soudní chemii 1.lékarské fakulty Univerzity Karlovy, Praha, Czech Republic.
Cerný
B
B
Vulterin
K
K
Labský
J
J
Vacík
J
J
Schneiderka
P
P
Roosová
M
M
D000107:Acetylation; D000818:Animals; D005260:Female; D008689:Methacrylates / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014316:Tritium
D008689:Methacrylates; D014316:Tritium; C005044:hydroxyethyl methacrylate