title: Huntington's disease.
abstract: Huntington's disease is a genetically inherited degenerative neuropsychiatric disorder, characterized by motor alterations, including involuntary movements such as chorea, dementia and psychiatric disturbances. In this article, the authors review the clinical features of the disease. They also analyze some genetic and pathophysiologic aspects, that can help to improve our understanding of this disorder involving the basal ganglia.
authors.affiliation: Department of Neurology, Hospital das Clínicas, University of São Paulo Medical School, Brazil.
authors.forename: M S
authors.initials: MS
authors.lastname: Haddad
authors.forename: J L
authors.initials: JL
authors.lastname: Cummings
mesh_terms: D001479:Basal Ganglia / Q000473:pathology / Q000503:physiopathology; D001526:Behavioral Symptoms; D018450:Disease Progression; D005819:Genetic Markers; D006801:Humans; D006816:Huntington Disease / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D009410:Nerve Degeneration / Q000503:physiopathology; D010166:Palliative Care / Q000379:methods
chemical_list: D005819:Genetic Markers