title: The efficiency of adiabatic inversion for perfusion imaging by arterial spin labeling.
abstract: Velocity-driven adiabatic inversion is an attractive method for labeling arterial blood spins for quantitative perfusion imaging. To quantify perfusion and to optimize experimental parameters, an accurate estimate of labeling efficiency is required. We present theoretical and numerical methods to calculate the labeling efficiency over a wide range of experimental and physiologic parameters. The results are compared to experimental measurements in vivo. Inversion efficiency was found to be higher than previously assumed and relatively insensitive to flow velocity and the amplitude of the RF irradiation used for inversion. Assuming laminar flow, labeling efficiencies of greater than 90% are easily obtainable over a broad range of flow velocities. For applications where RF power deposition is a limiting factor such as at high field strengths, labeling efficiency can be maintained by reducing the labeling gradient. These results further illustrate the capability of adiabatic inversion to effectively label flowing blood.
authors.affiliation: Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
authors.forename: L
authors.initials: L
authors.lastname: Maccotta
authors.forename: J A
authors.initials: JA
authors.lastname: Detre
authors.forename: D C
authors.initials: DC
authors.lastname: Alsop
mesh_terms: D000328:Adult; D001158:Arteries / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D010477:Perfusion; D013113:Spin Labels
chemical_list: D013113:Spin Labels; D010100:Oxygen