Biodegradation of phosphonomycin by Rhizobium huakuii PMY1.
The biodegradation by Rhizobium huakuii PMY1 of up to 10 mM phosphonomycin as a carbon, energy, and phosphorus source with accompanying P(i) release is described. This biodegradation represents a further mechanism of resistance to this antibiotic and a novel, phosphate-deregulated route for organophosphonate metabolism by Rhizobium spp.
McGrath
J W
JW
School of Biology and Biochemistry, Queen's University of Belfast, Northern Ireland. j.mcgrath@qub.ac.uk
Hammerschmidt
F
F
Quinn
J P
JP
D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D001673:Biodegradation, Environmental; D002244:Carbon / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005578:Fosfomycin / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D015394:Molecular Structure; D010758:Phosphorus / Q000378:metabolism; D012231:Rhizobium / Q000187:drug effects / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010758:Phosphorus; D005578:Fosfomycin; D002244:Carbon