Protein C and S deficiency in children with ischemic cerebrovascular accident.
A prothrombotic state caused by a deficiency of protein C or protein S, each an inhibitor of coagulation cascade, increases the risk of ischemic cerebrovascular accident (ICVA) in young adults. This retrospective review studies the relationship of protein C or S deficiency with childhood ICVA. From 1989 to 1995, 37 children were diagnosed by neuroimaging with ICVA unrelated to any known preexisting diagnosis. Protein C deficiency or protein S deficiency was the only identified risk factor for 5.4% (2 patients) and 13.5% (5 patients), respectively, of these 37 children. The data suggest that protein C or protein S deficiency is an important risk factor of ICVA in children.
Koh
S
S
Division of Neurology, Childrens Hospital Los Angeles, University of Southern California, 90027, USA.
Chen
L S
LS
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D002546:Ischemic Attack, Transient / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D020151:Protein C Deficiency; D018455:Protein S Deficiency / Q000150:complications* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors