title: [Tumor necrosis factor-alpha--biological and immunologic properties].
abstract: The studies investigating antitumor efficacy of bacterial infections, started by Coley, resulted in isolation of tumor necrosis factor (TNF-alpha), released by activated macrophages. It was hoped that direct and indirect cytotoxic, cytostatic and immunomodulatory effects of TNF-alpha would prove helpful in obtaining an effective antitumor drug. In this paper, we describe biologic and immunologic activity of cachectin as well as pre-clinical trials of TNF application in antitumor therapy.
authors.affiliation: Kliniki Chorób Wewnetrznych i Pneumonologii Instytutu Medycyny Wewnetrznej Centralnego Szpitala Klinicznego WAM w Warszawie.
authors.forename: A
authors.initials: A
authors.lastname: Chciałowski
authors.forename: T
authors.initials: T
authors.lastname: Targowski
authors.forename: I
authors.initials: I
authors.lastname: Bajera
authors.forename: K
authors.initials: K
authors.lastname: Jahnz-Rózyk
mesh_terms: D000818:Animals; D006801:Humans; D008262:Macrophage Activation; D009369:Neoplasms / Q000628:therapy; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D014409:Tumor Necrosis Factor-alpha