title: Clinical course of newly developed or progressive patchy chorioretinal atrophy in pathological myopia.
abstract: Regional chorioretinal atrophy in the posterior fundus (patchy chorioretinal atrophy) in pathological myopia impairs vision severely when it covers the macula. The aim of this study was to assess the course of development and progression of patchy chorioretinal atrophy in pathological myopia. The location and progression of patchy chorioretinal atrophy that was either newly developed or had progressed during the follow-up period (mean 5.25 years) were analyzed. A total of 41 lesions of patchy atrophy were newly developed in 30 eyes of 25 patients. These lesions were more likely to occur in marginal regions of a posterior staphyloma but frequency per unit area was highest in the macula. There were 138 lesions of patchy chorioretinal atrophy that progressed in 75 eyes of 53 patients. Sixty percent of the lesions of patchy chorioretinal atrophy in marginal regions of a posterior staphyloma spread toward the center. Seventy percent of the lesions of patchy chorioretinal atrophy in the macula spread in all directions. Fluorescein angiography of newly developed patchy chorioretinal atrophy showed hyperfluorescence in 50% and hypofluorescence in 27%. Fluorescein angiography of progressive lesions of patchy chorioretinal atrophy showed hypofluorescence in 69%. Fluorescein angiography of some progressive areas of patchy chorioretinal atrophy, which showed a change from hyperfluorescence to hypofluorescence within several years, suggested that damage to the retinal pigment epithelium preceded the progression of the patchy chorioretinal atrophy. In conclusion, the patchy chorioretinal atrophy is most likely to occur in the macula and to enlarge in all directions. And it is suggested that the patchy chorioretinal atrophy which shows hyperfluorescence by fluorescein angiography should be kept under observation because our data suggest that this finding indicates progression in the future.
authors.affiliation: Department of Ophthalmology, Tokyo Medical and Dental University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ito-Ohara
authors.forename: Y
authors.initials: Y
authors.lastname: Seko
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: N
authors.initials: N
authors.lastname: Imagawa
authors.forename: T
authors.initials: T
authors.lastname: Tokoro
mesh_terms: D000328:Adult; D000368:Aged; D001284:Atrophy; D001766:Blindness / Q000209:etiology; D002829:Choroid / Q000098:blood supply*; D015862:Choroid Diseases / Q000150:complications* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications* / Q000473:pathology; D012162:Retinal Degeneration / Q000150:complications* / Q000473:pathology; D014792:Visual Acuity