Effect of zopiclone on sleep, night-time ventilation, and daytime vigilance in upper airway resistance syndrome.
We have assessed the effects of zopiclone (7.5 mg), a new cyclopyrrolone hypnotic drug, on ventilation, sleep parameters, and daytime vigilance in snorers with upper airway resistance syndrome (UARS). Using a randomized double-blind design, eight male patients with UARS took either oral zopiclone or a placebo each evening for seven consecutive days and then crossed over to the other drug after a 7 day placebo period. Polysomnography followed by a multiple sleep latency test (MSLT) was performed during the last night of each treatment period. Zopiclone produced significant improvements in the sleep efficiency index (total sleep time/time in bed) (placebo 84+/-15% versus zopiclone 91+/-7%) and average MSLT (placebo 10.3+/-3.7 min versus zopiclone 14.9+/-2.8 min), as well as nonsignificant improvements in sleep onset latency and total sleep time. It had no effect on sleep architecture or on the arousal index (placebo 17+/-8 arousals x h(-1) versus zopiclone 17+/-4 arousals x h[-1]). Furthermore, none of the respiratory parameters were significantly affected by zopiclone. In conclusion, zopiclone has no adverse effects on sleep architecture, respiratory parameters during sleep, and daytime sleepiness in patients with UARS.
Lofaso
F
F
Institut National de la Santé et de la Recherche Médicale INSERM U 296, Hôpital Henri Mondor, Créteil, France.
Goldenberg
F
F
Thebault
C
C
Janus
C
C
Harf
A
A
D000403:Airway Resistance / Q000502:physiology*; D053961:Azabicyclo Compounds; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology* / Q000633:toxicity; D017286:Polysomnography; D012123:Pulmonary Ventilation / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects*; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D012894:Sleep Stages / Q000187:drug effects; D012913:Snoring / Q000503:physiopathology*; D013577:Syndrome
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone