Immunoglobulin high-dose therapy: RBC-alloantibodies in commercial preparations and haemolytic anaemia: a case report.
A 4-year-old girl with idiopathic thrombocytopenia, who received immunoglobulin (Ig) in high dosage, developed haemolytic anaemia. Incompatible alloantibodies but no autoantibodies were found in her blood. In vitro the Ig preparation led to a strong fixation of alloantibodies and C3 on the girl's RBCs. Because of these reactions we investigated 12 Ig preparations and found irregular alloantibodies in 7 of them. The guidelines for quality assurance and other possibilities for lowering side reactions are discussed.
Kluge
A
A
Institute for Immunology, University Hospital, Heidelberg.
Dopfer
R
R
Pfeiffer-Wolf
I
I
Roelcke
D
D
D000743:Anemia, Hemolytic / Q000209:etiology* / Q000276:immunology; D002675:Child, Preschool; D004340:Drug Contamination; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects* / Q000737:chemistry / Q000592:standards; D007518:Isoantibodies / Q000032:analysis / Q000097:blood*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000628:therapy*; D011786:Quality Control
D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies