title: Combined trabeculectomy and extracapsular cataract extraction with mitomycin C.
abstract: BACKGROUND
  To evaluate the long-term intraocular pressure (IOP) reduction effect and safety of adjunctive mitomycin C (MMC) (0.02%) in combined trabeculectomy and extracapsular cataract extraction (ECCE) procedure.
  
  
  METHODS
  Thirty of forty-one consecutive patients who underwent MMC trabeculectomy and ECCE with a minimum follow-up of 12 months were evaluated.
  
  
  RESULTS
  The mean IOP was reduced significantly (p < 0.001) from preoperative 19.2 +/- 3.2 mmHg to postoperative 12.1 +/- 2.7 mmHg, while the mean number of medications decreased from 2.1 to 0.2 at 1-year follow-up. Twenty-seven (90%) patients had IOPs controlled at 15 mmHg or less, and 26 (86.7%) patients required no medication. Net astigmatism and polar value converted from keratometric readings were 1.43 +/- 0.94 diopters and 0.07 +/- 1.38 diopters, respectively, in 1-year follow-up, which were not significantly different from the preoperative values.
  
  
  CONCLUSIONS
  Intraocular pressure could be maintained in the low teens without the need for medication in a majority of patients even one year after the combined procedure. No adverse effect on corneal endothelium or limbal wound healing was detected with intraoperative application of 0.02% MMC.
authors.affiliation: Department of Ophthalmology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: C J
authors.initials: CJ
authors.lastname: Liu
authors.forename: C C
authors.initials: CC
authors.lastname: Tsei
authors.forename: J C
authors.initials: JC
authors.lastname: Chou
authors.forename: J H
authors.initials: JH
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D014130:Trabeculectomy; D014792:Visual Acuity
chemical_list: D016685:Mitomycin