title: Enhanced expression of metallothionein in human non-small-cell lung carcinomas following chemotherapy.
abstract: Metallothioneins (MTs) are induced by various stimuli and probably confer drug resistance in tumor cells in vitro. To investigate whether MT expression in lung cancer is induced by chemotherapy, ninety-seven surgical specimens from patients who had or not received chemotherapy containing cisplatin, were stained immunohistochemically for MT. In untreated tumors, 23% (15/64) of all tumors and 27% (15/56) of non-small-cell carcinoma (NSCLC) stained positive, while all eight small-cell carcinoma (SCLC) were negative. In treated tumors, 52% (17/33) of all tumors, 80% (12/15) of NSCLC and 28% (5/18) of SCLC stained positive. The proportion of positively-stained tumors was significantly higher in treated NSCLC compared with untreated NSCLC (P = 0.0005) and treated SCLC (P < 0.005). Our results indicate that MT expression increases following chemotherapy and that such expression may confer during resistance in lung cancer, especially NSCLC.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: A
authors.initials: A
authors.lastname: Sakamoto
authors.forename: F
authors.initials: F
authors.lastname: Narasaki
authors.forename: M
authors.initials: M
authors.lastname: Fukuda
authors.forename: H
authors.initials: H
authors.lastname: Takatani
authors.forename: K
authors.initials: K
authors.lastname: Terashi
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: J
authors.initials: J
authors.lastname: Tsurutani
authors.forename: S
authors.initials: S
authors.lastname: Nagashima
authors.forename: H
authors.initials: H
authors.lastname: Soda
authors.forename: S
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000378:metabolism*; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D008668:Metallothionein / Q000378:metabolism*; D016685:Mitomycin / Q000008:administration & dosage; D009363:Neoplasm Proteins / Q000378:metabolism*; D014751:Vindesine / Q000008:administration & dosage
chemical_list: D009363:Neoplasm Proteins; D016685:Mitomycin; D005047:Etoposide; D008668:Metallothionein; D002945:Cisplatin; D014751:Vindesine