Interferon alpha reduces the level of radiation-induced micronuclei in mouse bone marrow cells.
The effect of natural mouse interferon alpha (IFN-alpha) on production of micronuclei (MN) in bone marrow cells of whole-body gamma-irradiated mice (in sublethal dose of 0.5 Gy from 60Co source) was studied. It was shown that free interferon alpha (IFN-alpha(F)) and IFN-alpha encapsulated into liposomes (IFN-alpha(L)), when injected intraperitoneally to mice prior to their irradiation, reduced substantially the frequency of gamma-ray-induced micronuclei in polychromatic erythrocytes (MN-PCE) of the bone marrow of these mice. The antimutagenic effect of IFN-alpha(F), as registered by the micronucleus test, was observed in bone marrow cells of mice irradiated 24 h after injection. For IFN-alpha(L), the decrease in MN frequency in PCE of mice was observed 48-72 h after administration of the preparation.
Fomenko
L
L
Laboratory of Molecular Radiobiology, Institute of Theoretical and Experimental Biophysics, Pushchino, Mascow Region, Russia.
Sirota
N
N
Ravin
V
V
Gaziev
A
A
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D004337:Drug Carriers; D005720:Gamma Rays; D007274:Injections, Intraperitoneal; D016898:Interferon-alpha / Q000008:administration & dosage / Q000494:pharmacology*; D008081:Liposomes; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D015162:Micronucleus Tests; D011828:Radiation Chimera
D004337:Drug Carriers; D016898:Interferon-alpha; D008081:Liposomes