T-cell receptor structure and TCR complexes.
The first crystal structures of intact T-cell receptors (TCRs) and their complexes with MHC peptide antigens (pMHC) were reported during the past year, along with those of a single-chain TCR Fv fragment and a beta-chain complexed with two different bacterial superantigens. These structures have shown the similarities and differences in the architecture of the antigen-binding regions of TCRs and antibodies, and how the TCR interacts with pMHC ligands as well as with superantigens.
Wilson
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Department of Molecular Biology, Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USA. wilson@scripps.edu
Garcia
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D000818:Animals; D000942:Antigens, Bacterial / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D001665:Binding Sites; D018360:Crystallography, X-Ray; D006649:Histocompatibility Antigens / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D018089:Superantigens / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism
D000942:Antigens, Bacterial; D006649:Histocompatibility Antigens; D011948:Receptors, Antigen, T-Cell; D018089:Superantigens