Retrograde transport: going against the flow.
Certain protein toxins act by catalytically modifying substrates in the cytosol of mammalian cells. To reach this compartment, these proteins undergo retrograde transport from the cell surface, via the Golgi complex, to the endoplasmic reticulum.
Lord
J M
JM
Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK.
Roberts
L M
LM
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D014118:Toxins, Biological / Q000378:metabolism*
D014118:Toxins, Biological