Actin-positive chondroblasts (myochondroblasts) in benign chondroblastoma.
We studied the result of immunostaining for muscle specific actin in 15 chondroblastomas and observed distinct muscle actin positive chondroblasts and chondrocytes in five cases. In their cytoplasm actin positive cells contained bundles of microfilaments with focal densities on the ultrastructural level, but they differed from myofibroblasts in many aspects. Analogously to the terminology of myofibroblasts such cells can be probably designated as myochondroblasts having characteristic immunophenotype (vimentin, S-100 protein, NSE and muscle actin positivity).
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IInd Institute of Pathology, 1st Medical Faculty, Charles University, Prague.
D000199:Actins / Q000032:analysis*; D001859:Bone Neoplasms / Q000737:chemistry / Q000648:ultrastructure*; D002804:Chondroblastoma / Q000737:chemistry / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry
D000199:Actins