[Recent progress of molecular immunology on inflammatory myopathy].
The pathogenesis of polymyositis(PM), T-cell-mediated disease, and dermatomyositis(DM), humoral immunity-mediated disease, has not been clearly understood. Retroviruses(HIV, HTLV-I) may play a important role in some PM/DM patients. HTLV-I provirus was detected in infiltrating CD4+ lymphocytes, but not within the muscle fibers by PCR in situ hybridization. It is suggested that HTLV-I-associated PM is not due to direct, persistent infection of the muscle fiber by the virus, but to a T-cell-mediated immunological process triggered by the HTLV-I-infected cells. Inclusion body myositis(IBM) is characterized pathologically by vacuolated muscle fibers containing paired-helical filaments(PHFs) similar to Alzheimer-disease brain. Furthermore, prion protein and mRNA are abnormally accumulated in IBM muscle.
Higuchi
I
I
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University.
Osame
M
M
D015551:Autoimmunity; D003882:Dermatomyositis / Q000276:immunology*; D006678:HIV / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D018979:Myositis, Inclusion Body / Q000209:etiology; D017285:Polymyositis / Q000276:immunology*; D011328:Prions / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D011328:Prions; D012333:RNA, Messenger