Involvement of interleukin-3 in delayed-type hypersensitivity.
The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell-dependent sensitization to tumor cells. These findings reveal a critical role for IL-3 in some forms of delayed-type hypersensitivity.
Mach
N
N
Department of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Lantz
C S
CS
Galli
S J
SJ
Reznikoff
G
G
Mihm
M
M
Small
C
C
Granstein
R
R
Beissert
S
S
Sadelain
M
M
Mulligan
R C
RC
Dranoff
G
G
D000818:Animals; D003877:Dermatitis, Contact; D006410:Hematopoiesis; D006968:Hypersensitivity, Delayed; D007377:Interleukin-3 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016296:Mutagenesis; D009374:Neoplasms, Experimental / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
D007377:Interleukin-3