Granulocyte colony-stimulating factor administration increases serum concentrations of soluble selectins.
In order to explore the possible role of granulocyte colony-stimulating factor (G-CSF) in the inflammatory process, we examined the serum concentrations of soluble selectins (sL-selectin, sE-selectin and sP-selectin) following in vivo administration of G-CSF to five healthy volunteers and 12 neutropenic patients with haematological malignancies. The serum concentrations of both sL-selectin and sE-selectin were slightly but significantly increased after G-CSF administration in the healthy volunteers. The serum concentrations of all three selectins were significantly increased after G-CSF administration in the neutropenic patients concomitant with an increase in their neutrophil counts. These findings suggest that G-CSF may participate in the leucocyte-endothelial cell interactions in vivo.
Ohsaka
A
A
Department of Internal Medicine, Hitachi General Hospital, Ibaraki, Japan.
Saionji
K
K
Igari
J
J
D000328:Adult; D000368:Aged; D019040:E-Selectin / Q000097:blood*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D019337:Hematologic Neoplasms / Q000097:blood; D006801:Humans; D019041:L-Selectin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood; D019007:P-Selectin / Q000097:blood*
D019040:E-Selectin; D019007:P-Selectin; D019041:L-Selectin; D016179:Granulocyte Colony-Stimulating Factor