title: Diabetic eye disease: a natural history study.
abstract: In previous studies on diabetic retinopathy it has not been possible to relate risk factors to reduced vision because of the influence of vision-preserving treatment. Demographic data, cardiovascular risk factors and ocular features from the diabetic population of the Seychelles are described. Diabetic retinopathy in this population had not been modified by laser treatment. The population described consists of entirely type 2, maturity onset diabetics. Using a multivariate logistic regression model, the risk factors were deduced for three outcome variables: (1) reduced vision, defined as 6/36 or worse in both eyes; (2) the presence of diabetic retinopathy; and (3) the presence of maculopathy, preproliferative and proliferative retinopathy, grouped as severe retinopathy. Insulin treatment was associated with all outcome variables, duration from diagnosis of diabetes with retinopathy of all forms, and increasing age with reduced vision and severe retinopathy. Hypertensive diabetic patients were twice as likely to have reduced vision as compared with non-hypertensive diabetic individuals.
authors.affiliation: Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK. rtaylor@yorkeyes.demon.co.uk
authors.forename: R H
authors.initials: RH
authors.lastname: Taylor
authors.forename: H S
authors.initials: HS
authors.lastname: Jones
authors.forename: P M
authors.initials: PM
authors.lastname: Dodson
authors.forename: A P
authors.initials: AP
authors.lastname: Hamilton
authors.forename: E E
authors.initials: EE
authors.lastname: Kritzinger
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003906:Developing Countries; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D003930:Diabetic Retinopathy / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D012750:Seychelles / Q000453:epidemiology; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity
chemical_list: D007328:Insulin