Longitudinal follow-up of two AIDS patients for active human herpesvirus-6 (HHV-6) infection.
Because of the demonstrated presence of Human Herpesvirus-6 (HHV-6) in various tissues and organs of HIV-1 infected AIDS patients, and its implication in the pathogenesis of AIDS, we followed two AIDS patients for active HHV-6 infection for two years. Evidence of active HHV-6 infection was demonstrated by immunovirologic assays in both patients; however, the profile of infection in the two patients varied. One patient showed appearance and disappearance of HHV-6, indicating virus reactivation, whereas the other patient showed chronic or persistent HHV-6 infection. Both patients' peripheral blood mononuclear cells (PBMC) contained HIV-1 when their CD4 cell count was approximately 200 mm3. No active HHV-6 was demonstrated in a healthy donor, who was used as a control for this study.
Ablashi
D V
DV
Advanced Biotechnologies Inc., Columbia, MD 21046, USA.
Chatlynne
L G
LG
Whitman
J E
JE
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D004279:DNA, Viral / Q000097:blood; D004268:DNA-Binding Proteins / Q000276:immunology; D005500:Follow-Up Studies; D006566:Herpesviridae Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D014764:Viral Proteins / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D014764:Viral Proteins; C098303:p38 protein, Human herpesvirus 6; C081690:p41 protein, Human herpesvirus 6