title: How grapefruit juice potentiates drug bioavailability.
abstract: Grapefruit juice enhances the effect of some commonly used medications by increasing their bioavailability via the selective down-regulation of a specific subfamily of the cytochrome P450 enzyme system in the small intestine.
authors.affiliation: Medical College of Georgia, Augusta 30904-4333, USA.
authors.forename: E B
authors.initials: EB
authors.lastname: Feldman
mesh_terms: D019540:Area Under Curve; D001628:Beverages; D001682:Biological Availability; D002121:Calcium Channel Blockers / Q000097:blood / Q000493:pharmacokinetics*; D002957:Citrus; D015536:Down-Regulation; D004357:Drug Synergism; D015736:Felodipine / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans
chemical_list: D002121:Calcium Channel Blockers; D015736:Felodipine