[Measurement of fecal lactoferrin for diagnosis on pediatric gastrointestinal disease].
The fecal proteins in blood and granules related with inflammation have been measured to examine the conditions of inflammation in inflammatory bowel disease (IBD). To noninvasively examine the conditions in pediatric patients with various gastrointestinal diseases, we evaluated the usefulness of measuring the concentration of fecal lactoferrin (Lf), which is the specific granule component in neutrophils. Lf was measured by ELISA in patients with infectious enteritis (E), Henoch Schönlein purpura (HSP), and ulcerative colitis (UC), and in control subjects. The fecal Lf levels were significantly higher in patients with E, HSP, and UC than in control subjects. The fecal Lf levels were significantly increased in not only patients with bacterial but also those with viral gastroenteritis. These findings suggest that the measurement of fecal Lf concentration is useful for noninvasive monitoring of the disease activity in pediatric patients with gastrointestinal disease and the activities of neutrophils elevate in patients with viral infectious enteritis.
Tabata
K
K
Kyoto Medical Science Laboratory.
Matsuse
R
R
Uchida
K
K
Amemoto
K
K
D002648:Child; D003093:Colitis, Ulcerative / Q000175:diagnosis; D004751:Enteritis / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000737:chemistry*; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000821:virology; D006801:Humans; D007781:Lactoferrin / Q000032:analysis*
D007781:Lactoferrin