title: Synthesis of certain 5-substituted 2-thiohydantoin derivatives as potential cytotoxic and antiviral agents.
abstract: A convenient route is reported for the synthesis of certain series of 2-thiohydantoins carrying various heterocyclic substituents such as 5-bromothienylidene 3a,b, 5-(2-carboxyphenylthio)-2-thienylidene 4a,b and 4H-thieno[2,3-b][1]benzothiopyran-4-one 5a,b. Glycosylation of these thiohydantoins afforded the S-glycosyl derivatives 10a-d. The synthesized compounds were tested for their activity against HIV-1 virus and as antitumor agents.
authors.affiliation: Department of Chemistry, Faculty of Education, Kafr El-Sheikh Branch, Tanta University, Egypt.
authors.forename: A I
authors.initials: AI
authors.lastname: Khodair
authors.forename: H I
authors.initials: HI
authors.lastname: el-Subbagh
authors.forename: A A
authors.initials: AA
authors.lastname: el-Emam
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D006827:Hydantoins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D006827:Hydantoins