Reduction of serum retinol levels following a single oral dose of all-trans retinoic acid in humans.
Following a single oral dose of all-trans retinoic acid (RA) (0.167 mmole) in corn oil to 6 healthy human subjects, the mean serum retinol (ROL) level fell by approximately 20% within 1 h and remained depressed for 24 h. After dosing, RA appeared in the blood within 30 min, peaked at 0.3-0.5 mumol/l, and then declined to very low concentrations after 7 h. All-trans retinoyl beta-glucuronide (RAG) appeared simultaneously with RA in the plasma, albeit more sporadically, whereas only traces of 4-oxoretinoic acid (4-oxoRA) were detected. Some possible physiologic consequences of therapeutic uses of all-trans RA are discussed.
Barua
A B
AB
Department of Biochemistry & Biophysics, Iowa State University, Ames 50011, USA.
Duitsman
P K
PK
Kostic
D
D
Barua
M
M
Olson
J A
JA
D000328:Adult; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D014212:Tretinoin / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood; D014801:Vitamin A / Q000097:blood*
D014801:Vitamin A; C002202:4-oxoretinoic acid; C026787:retinoyl glucuronide; D014212:Tretinoin