title: The syndrome of autoimmune interstitial nephritis and membranous nephropathy.
abstract: A 2-year-old male patient was evaluated for Fanconi syndrome with hypertension and failure to thrive. Renal biopsy revealed autoimmune interstitial nephritis with membranous nephropathy. The patient developed autoimmune hemolytic anemia and intractable diarrhea with villous atrophy of the jejunum. He progressed to end-stage renal disease and was transplanted without recurrent disease. Immune work-up done prior to immunosuppressive therapy showed marked elevation of IgE. Studies of T lymphocyte cytokine production showed normal production of interleukin-4 but depressed levels of interferon-gamma. The simultaneous occurrence of autoimmune interstitial nephritis and membranous nephropathy in a young male represents a unique syndrome. Abnormalities of T lymphocyte subpopulations and their cytokines may be involved in the pathogenesis of this disorder.
authors.affiliation: The Department of Pediatrics, University of California at San Diego and Children's Hospital and Health Center of San Diego, 92103, USA.
authors.forename: W R
authors.initials: WR
authors.lastname: Griswold
authors.forename: H F
authors.initials: HF
authors.lastname: Krous
authors.forename: V
authors.initials: V
authors.lastname: Reznik
authors.forename: J
authors.initials: J
authors.lastname: Lemire
authors.forename: N W
authors.initials: NW
authors.lastname: Wilson
authors.forename: J
authors.initials: J
authors.lastname: Bastian
authors.forename: H
authors.initials: H
authors.lastname: Spiegelberg
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D004485:Eczema / Q000473:pathology; D015433:Glomerulonephritis, Membranous / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D008206:Lymphatic Diseases / Q000473:pathology; D008222:Lymphokines / Q000378:metabolism; D008297:Male; D009395:Nephritis, Interstitial / Q000276:immunology / Q000473:pathology*; D013577:Syndrome
chemical_list: D008222:Lymphokines