The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy.
The present article reviews the role of the second messenger enzyme protein kinase C (PKC) in the growth regulation of high-grade gliomas, and evaluates the efficacy of therapeutic strategies directed against PKC for blocking the proliferation of these malignancies in in vitro and in vivo models. The translation of such strategies to the treatment of patients with malignant gliomas may provide a novel approach for improving the otherwise grim outlook associated with these neoplasms.
Bredel
M
M
Department of Neurosurgery, University of Pittsburgh School of Medicine, PA, USA.
Pollack
I F
IF
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000502:physiology*
D004791:Enzyme Inhibitors; D011493:Protein Kinase C