[Comparison of the effect of selected cholinesterase reactivators combined with atropine on soman and fosdrin toxicity in mice].
The efficacy of cholinesterase reactivators tetroxime, HI-6 and obidoxime in combination with atropine against highly toxic organophosphate soman as well as organophosphorus insecticide fosdrin was evaluated in male mice using median lethal dose (LD50) for 48 hours. Oxime HI-6 appears to be considerably more effective than tetroxime as well as obidoxime for the treatment of acute poisonings by soman or fosdrin, although the difference in effect is not significant in the case of poisoning by fosdrin. These findings suggest that HI-6 has definite advantage over obidoxime as well as tetroxime in the treatment of poisoning with not only highly toxic organophosphates but also organophoshorus insecticides.
Kassa
J
J
Vojenská Lékarská akademie JEP, Hradec Králové.
D000818:Animals; D000931:Antidotes / Q000008:administration & dosage*; D001285:Atropine / Q000008:administration & dosage*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage*; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D008799:Mevinphos / Q000506:poisoning*; D051379:Mice; D011041:Poisoning / Q000188:drug therapy; D012999:Soman / Q000506:poisoning*
D000931:Antidotes; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D008799:Mevinphos; D001285:Atropine; D012999:Soman