title: Increased urinary-free cortisol outputs in diabetic patients.
abstract: We previously reported that diabetic patients show evidence of dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. To extend this work, we examined urinary-free cortisol (UFC) outputs in diabetic patients and whether or not they relate to diabetic complications. We compared a group of 35 insulin-dependent diabetic outpatients with a group of 32 normal controls for 24-h UFC outputs and examined the patients for relationship between UFC outputs and diabetic complications. Diabetic patients had significantly greater 24-h UFC outputs than controls. There was a significant positive correlation between 24-h UFC outputs and duration of diabetes. There were trends for patients with either diabetic retinopathy or diabetic cardiovascular complications to have higher 24-h UFC outputs than patients without these complications. These results further show that diabetic patients have mild dysregulation of the HPA axis. This dysregulation is related to longer duration of diabetes. A larger sample is needed to examine further for a relationship to diabetic complications.
authors.affiliation: Department of Ophthalmology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103-2499, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Roy
authors.forename: A
authors.initials: A
authors.lastname: Roy
authors.forename: S
authors.initials: S
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D000328:Adult; D002096:C-Peptide / Q000097:blood; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000209:etiology / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology
chemical_list: D002096:C-Peptide; D006442:Glycated Hemoglobin; D006854:Hydrocortisone