Relation between leucocyte depletion and storage.
We intended to answer two questions: (1) Does storage time of platelet concentrates (PCs) influence the efficacy of leucocyte depletion by filtration? (2) Does pre-storage leucocyte depletion by filtration of PCs improve the post-storage quality? To this end we tested in parallel the halves of 10 double-sized PCs, one half stored after filtration through a polyester filter (PL 50, Pall), the other half filtered after a 5-day storage period. Efficacy of leucocyte depletion showed to be independent of the age of PCs, and pre-storage leucocyte depletion of PCs was not able to improve the quality of PCs stored for 5 days, as long as the leucocyte contamination of unfiltered PCs was lower than 0.5 x 10(8)/unit.
Weisbach
V
V
Abteilung für Transfusionsmedizin, Chirurgische Klinik, FAU Erlangen-Nürnberg.
Riewald
M
M
Zingsem
J
J
Putzo
A
A
Zimmermann
R
R
Zeiler
T
T
Riess
H
H
Eckstein
R
R
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000166:cytology; D001793:Blood Preservation; D003094:Collagen / Q000494:pharmacology; D005374:Filtration / Q000379:methods; D006801:Humans; D007962:Leukocytes; D010974:Platelet Aggregation / Q000187:drug effects; D010983:Plateletpheresis / Q000379:methods*; D013917:Thrombin / Q000494:pharmacology; D013997:Time Factors
D000244:Adenosine Diphosphate; D003094:Collagen; D013917:Thrombin