Specific problems facing gene therapy for insulin-dependent diabetes mellitus: glucose-regulated insulin secretion from hepatocytes.
Wanke
I E
IE
Department of Medicine, Faculty of Medicine, University of Calgary, Canada.
Wong
N C
NC
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D005947:Glucose / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008099:Liver / Q000378:metabolism*; D009687:Nuclear Proteins; D011384:Proinsulin / Q000235:genetics; D011401:Promoter Regions, Genetic; D011498:Protein Precursors / Q000235:genetics; D011506:Proteins / Q000235:genetics; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D014157:Transcription Factors; D014162:Transfection; D014407:Tumor Cells, Cultured
D007328:Insulin; D009687:Nuclear Proteins; D011498:Protein Precursors; D011506:Proteins; D011993:Recombinant Fusion Proteins; C051065:THRSP protein, human; C501478:Thrsp protein, rat; D014157:Transcription Factors; C013737:preproinsulin; D011384:Proinsulin; D005947:Glucose