Plagiarism of the host immune system: lessons about chemokine immunology from viruses.
In their attempts to evade the host immune response, mammalian viruses have evolved a wide range of strategies. These include the expression and modification of various host cytokines and receptors. Understanding the mechanism of action of these virally encoded proteins will clearly deepen our insights into immunology. In the past few months several new virally encoded chemokines have been described which can modify both the host immune and antiviral response. Their manipulation of the cytokine structure-function relationship may also be useful in the development of reagents for treating immune and proliferative diseases.
Wells
T N
TN
Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development SA, Switzerland. tncw5312@ggr.co.uk
Schwartz
T W
TW
D000595:Amino Acid Sequence; D018925:Chemokines / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000235:genetics
D018925:Chemokines; D019707:Receptors, Chemokine