title: Enhanced resting left ventricular filling in patients with successful coarctation repair and exercise-induced hypertension.
abstract: M-mode and Doppler echocardiographic analyses of left ventricular (LV) shortening and filling were performed in 50 patients who underwent coarctectomy (median follow-up 9.5 years) and in 16 athletes in a control group before an exercise stress test with upright bicycle ergometry was performed. Thirty-two of 50 patients and 18 of 50 patients had a normotensive and hypertensive response to exercise, respectively. Preexercise echocardiographic data were compared among the control, normotensive, and hypertensive patient groups. LV peak filling rates (dD/dt, diastole) were increased in the hypertensive group (18.3 +/- 3.5) compared with those in the normotensive group (14.4 +/- 3.2; p < 0.001) and the control group (13.6 +/- 2.8; p < 0.001). LV shortening was enhanced in the coarctectomy group compared with that in the control group. A higher aortic isthmus Doppler gradient at peak exercise was not found in the hypertensive group compared with that in the normotensive group. Therefore patients with successful coarctectomy in childhood have enhanced LV shortening and relaxation at rest. Demonstration of enhanced LV peak filling rates may help identify patients at risk for exercise-induced hypertension.
authors.affiliation: Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201, USA.
authors.forename: M V
authors.initials: MV
authors.lastname: Tantengco
authors.forename: R D
authors.initials: RD
authors.lastname: Ross
authors.forename: R A
authors.initials: RA
authors.lastname: Humes
authors.forename: N M
authors.initials: NM
authors.lastname: Sullivan
authors.forename: V M
authors.initials: VM
authors.lastname: Joshi
authors.forename: S K
authors.initials: SK
authors.lastname: Clapp
authors.forename: M L
authors.initials: ML
authors.lastname: Epstein
mesh_terms: D000293:Adolescent; D000328:Adult; D001017:Aortic Coarctation / Q000601:surgery*; D002648:Child; D003971:Diastole; D015150:Echocardiography, Doppler; D005080:Exercise Test; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D013599:Systole; D016277:Ventricular Function, Left