title: Identification of two novel peptides from the central nervous system of the desert locust, Schistocerca gregaria.
abstract: From an acid methanolic extract of about 7000 brains of the desert locust (Schistocerca gregaria) two novel neuropeptides, schistomyotropin-1 (Scg-MT-1) and schistomyotropin-2 (Scg-MT-2), were isolated and identified. Their primary structures are GAAPAAQFSPRLamide (Scg-MT-1) and TSSLFPHPRLamide (Scg-MT-2). Scg-MT-1 belongs to the locustamyotropin family characterized by its FXPRLamide C-terminus. Scg-MT-2 has a similar carboxyl end with the F-residue one position further away from the C-terminus. This may account for its being 10 times less active then Scg-MT-1 in stimulating cockroach hindgut motility.
authors.affiliation: Laboratory for Developmental Biology and Molecular Biology, Zoological Institute, Leuven, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Veelaert
authors.forename: L
authors.initials: L
authors.lastname: Schoofs
authors.forename: P
authors.initials: P
authors.lastname: Verhaert
authors.forename: A
authors.initials: A
authors.lastname: De Loof
mesh_terms: D000818:Animals; D001681:Biological Assay; D002490:Central Nervous System / Q000737:chemistry*; D006110:Grasshoppers / Q000737:chemistry*; D009132:Muscles / Q000187:drug effects; D009479:Neuropeptides / Q000737:chemistry* / Q000494:pharmacology; D017421:Sequence Analysis
chemical_list: D009479:Neuropeptides; C109814:schistomyotropin-2