Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses.
The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.
Parolin
C
C
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Borsetti
A
A
Choe
H
H
Farzan
M
M
Kolchinsky
P
P
Heesen
M
M
Ma
Q
Q
Gerard
C
C
Palú
G
G
Dorf
M E
ME
Springer
T
T
Sodroski
J
J
D000818:Animals; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D051379:Mice; D054398:Receptors, CCR4; D019707:Receptors, Chemokine / Q000502:physiology*; D011991:Receptors, Virus / Q000502:physiology*; D013601:T-Lymphocytes / Q000821:virology*; D014779:Virus Replication
C515354:CCR4 protein, human; C515355:Ccr4 protein, mouse; D054398:Receptors, CCR4; D019707:Receptors, Chemokine; D011991:Receptors, Virus