Hyperthermic treatment of malignant diseases: current status and a view toward the future.
New studies in hyperthermia at the basic science, engineering, and clinical level have stimulated renewed enthusiasm for re-investigating its potential as an anticancer therapy. This article reviews the salient features of these recent results and points out areas for additional investigation. Highlighting these new results is the publication of several positive phase III trials for thermoradiotherapy compared to radiotherapy alone. Important highlights are the encouraging results using magnetic resonance imaging for noninvasive thermometry. If this technology is successfully implemented with real time power control it will revolutionize the clinical application of hyperthermia.
Dewhirst
M W
MW
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
Prosnitz
L
L
Thrall
D
D
Prescott
D
D
Clegg
S
S
Charles
C
C
MacFall
J
J
Rosner
G
G
Samulski
T
T
Gillette
E
E
LaRue
S
S
D000818:Animals; D017326:Clinical Trials, Phase III as Topic; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D006979:Hyperthermia, Induced; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D018787:Radiation Oncology / Q000639:trends*; D013816:Thermodynamics