Clinical implication of expression of progesterone receptor form A and B mRNAs in secondary spreading of gynecologic cancers.
This study was designed to determine the clinical implication of expression of progesterone receptor form A (PR-A) and B (PR-B) mRNAs in secondary spreading of gynecologic cancers. Approximately equal expression of PR-A and PR-B mRNAs was designated as type AB and dominant expression of PR-B mRNA as type B. Alteration from type AB to type B in the metastatic cancers occurred in 3/8 cases of uterine endometrial cancers, 2/8 cases of uterine cervical cancers, and 2/8 cases of ovarian cancers. Other cancers revealed type B regardless of primary or metastatic status. Thus, all metastatic cancers studied revealed type B. These results suggest that transcription of PR-A mRNA may be damaged, which might lead to uncontrolled overexpression of PR-B mRNA in metastatic lesion, and that the type B status could reveal a highly malignant phenotype in these three gynecologic cancers.
Fujimoto
J
J
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan.
Ichigo
S
S
Hirose
R
R
Sakaguchi
H
H
Tamaya
T
T
D000328:Adult; D000368:Aged; D017931:DNA Primers / Q000235:genetics; D005260:Female; D015870:Gene Expression; D005833:Genital Neoplasms, Female / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000235:genetics* / Q000378:metabolism* / Q000556:secondary; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000235:genetics* / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000235:genetics*
D017931:DNA Primers; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D011980:Receptors, Progesterone