title: Cylindrical spirals of myofilamentous origin associated with exertional cramps and rhabdomyolysis.
abstract: We describe the presence of cylindrical spirals on muscle biopsy from a 31-year-old man who developed rhabodomyolysis following a long run. He had a prior history of exertional cramps and myoglobinuria. His maternal grandfather had similar symptoms. Transmission electron micrographs demonstrated continuity between the lamellae of the cylindrical spirals and native myofilaments. Whether these unusual structures confer a derangement in myofilament function is uncertain.
authors.affiliation: Department of Neurology, University of Texas Southwestern Medical Center, Dallas 75235-8897, USA.
authors.forename: G I
authors.initials: GI
authors.lastname: Wolfe
authors.forename: D K
authors.initials: DK
authors.lastname: Burns
authors.forename: D
authors.initials: D
authors.lastname: Krampitz
authors.forename: R J
authors.initials: RJ
authors.lastname: Barohn
mesh_terms: D008841:Actin Cytoskeleton / Q000473:pathology*; D000328:Adult; D001706:Biopsy; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009120:Muscle Cramp / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D005082:Physical Exertion / Q000502:physiology*; D012206:Rhabdomyolysis / Q000473:pathology*