Symptomatic hepatic cysts: treatment with single-shot injection of minocycline hydrochloride.
OBJECTIVE
To assess the efficacy of percutaneous minocycline hydrochloride sclerotherapy in symptomatic hepatic cysts.


METHODS
From November 1992 to June 1994, seven of eight consecutive adults with large symptomatic hepatic cysts (diameter, 55-130 mm) were treated with a single intracystic injection of minocycline hydrochloride in an ambulatory procedure. Five patients had a solitary cyst, and two had polycystic liver disease. The target cyst was punctured under ultrasound guidance and local anesthesia with a 22-gauge Chiba needle. Half of the cyst content was aspirated before injection of 100-500 mg of minocycline hydrochloride diluted in 5-25 mL of saline. The minocycline hydrochloride was left in the cyst at the end of the procedure.


RESULTS
After a mean follow-up of 28 months (range, 24-42 months), all five patients with solitary cysts were asymptomatic and four had documented complete cyst regression; the two patients with multiple hepatic cysts showed only transient clinical improvement.


CONCLUSIONS
Single-shot injection of minocycline hydrochloride is an effective treatment for symptomatic solitary hepatic cysts but is less effective in polycystic liver disease.
Cellier
C
C
Department of Gastroenterology, Université René Descartes, Hôpital Laennec, Paris, France.
Cuenod
C A
CA
Deslandes
P
P
Auroux
J
J
Landi
B
B
Siauve
N
N
Barbier
J P
JP
Frija
G
G
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003560:Cysts / Q000000981:diagnostic imaging / Q000628:therapy*; D004322:Drainage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage* / Q000627:therapeutic use; D011446:Prospective Studies; D011859:Radiography; D015911:Sclerotherapy; D013997:Time Factors; D014463:Ultrasonography
D000900:Anti-Bacterial Agents; D008911:Minocycline