title: Benefits of early thymectomy in patients with myasthenia gravis.
abstract: OBJECTIVE
  To report our experience of early thymectomy in patients with myasthenia gravis.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  University department of surgery, Greece.
  
  
  METHODS
  76 Patients with myasthenia gravis.
  
  
  METHODS
  Transcervical thymectomy in all cases, additional left thoracotomy in four cases.
  
  
  METHODS
  Mortality, morbidity, and early (6 months) and late (mean follow-up 4.8 years) response to thymectomy.
  
  
  RESULTS
  20 Patients had thymomas (26%). There was no postoperative mortality; morbidity was 11% (n = 8). There was complete remission in 19 (25%), improvement in 49 (65%) no change in 7 (9%), and impairment in 1 (1%) of the patients at 6 months. Patients who had had symptoms for less than 5 years (p < 0.001), were in an earlier stage of disease (p = 0.006), and who did not have thymomas (p = 0.006) responded better. 3 Patients died of invasive thymoma at 2 1/2, 3, and 5 1/2 years postoperatively and 25/76 (33%) were lost to follow-up. Of the 51 patients available for late follow-up, 19 (37%) were in remission, in 26 (51%) the symptoms had improved, 3 (6%) were unchanged, and 3 (6%) had died of the disease.
  
  
  CONCLUSIONS
  Transcervical thymectomy should be considered in patients with early myasthenia gravis.
authors.affiliation: First Department of Surgery, University of Athens, Laikon General Hospital, Greece.
authors.forename: J
authors.initials: J
authors.lastname: Bramis
authors.forename: E
authors.initials: E
authors.lastname: Pikoulis
authors.forename: A
authors.initials: A
authors.lastname: Leppäniemi
authors.forename: E
authors.initials: E
authors.lastname: Felekouras
authors.forename: D
authors.initials: D
authors.lastname: Alexiou
authors.forename: E
authors.initials: E
authors.lastname: Bastounis
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009017:Morbidity; D009157:Myasthenia Gravis / Q000453:epidemiology / Q000209:etiology / Q000601:surgery*; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome