Prior segregation analysis and the power to detect linkage.
Complex parametric segregation and linkage analysis was performed on the simulated quantitative trait Q1 for all 200 replicates of the nuclear families data set. The segregation analysis inferred a major gene in 46% of the replicates. Among all replicates, including those that rejected a major gene, the power to detect suggestive linkage to any of three loci affecting Q1 was 0.600 and the false positive rate was 0.002. Among the replicates where a major gene was found, the power to detect suggestive linkage was 0.652 and the false positive rate was also 0.002. Thus, for purposes of linkage to this complex trait, a prior segregation then linkage analysis approach located a gene in 30% of all replicates, whereas a linkage only approach located a gene in 60% of all replicates.
Atwood
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Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA.
Slifer
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SH
D003198:Computer Simulation; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D008540:Meiosis / Q000235:genetics*; D008957:Models, Genetic; D009679:Nuclear Family; D011237:Predictive Value of Tests; D019655:Quantitative Trait, Heritable