Increased adhesiveness of white blood cells in patients with unstable angina: additional evidence for an involvement of the immune-inflammatory system.
BACKGROUND
Data are being accumulated on the presence of inflammatory response in patients with acute coronary syndromes.


OBJECTIVE
The study was undertaken to confirm that the adhesive state of the peripheral blood leukocytes can provide information on an inflammatory process in patients with unstable angina pectoris.


METHODS
The study included 21 patients with unstable angina, 32 patients with stable angina, and 13 patients with chest pain and no evidence of coronary artery disease.


RESULTS
The percentage of aggregated leukocytes in patients with unstable angina (5.8 +/- 3.2%) was significantly (p < 0.02) increased compared with that of patients with no evidence of active coronary disease (3.2 +/- 2.6%).


CONCLUSIONS
Additional evidence for an existing smoldering inflammatory process in unstable angina pectoris can be provided by testing the percentage of aggregated leukocytes in peripheral blood.
Leibovitz
E
E
Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Israel.
Hertz
Y
Y
Liberman
E
E
Sclarovsky
S
S
Berliner
S
S
D000268:Adhesiveness; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002448:Cell Adhesion / Q000276:immunology*; D002449:Cell Aggregation / Q000276:immunology; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D015415:Biomarkers