title: Dopamine uptake sites, labelled with [3H]GBR12935, in brain samples from depressed suicides and controls.
abstract: We have quantitated dopamine uptake sites, labelled with [3H]GBR12935, in caudate, putamen and nucleus accumbens of suicides with a retrospective diagnosis of depression, and age and gender-matched controls. Suicides were subdivided into those who had been free of antidepressant drugs for at least three months, and those in whom prescription of antidepressant drugs was clearly documented. We found no significant differences between controls and suicides overall, or when the suicides were divided on the basis of antidepressant treatment or violence of death. A significant negative correlation between the number of dopamine uptake sites and age was found in each region studied. Our results suggest dopamine uptake sites are not critically involved in depression or antidepressant drug action.
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Bowden
authors.forename: S C
authors.initials: SC
authors.lastname: Cheetham
authors.forename: S
authors.initials: S
authors.lastname: Lowther
authors.forename: C L
authors.initials: CL
authors.lastname: Katona
authors.forename: M R
authors.initials: MR
authors.lastname: Crompton
authors.forename: R W
authors.initials: RW
authors.lastname: Horton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism* / Q000523:psychology*; D004298:Dopamine; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009714:Nucleus Accumbens / Q000378:metabolism; D010879:Piperazines / Q000378:metabolism; D011699:Putamen / Q000378:metabolism; D013405:Suicide; D014316:Tritium
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010879:Piperazines; D014316:Tritium; C044630:1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine; D004298:Dopamine