title: [Use of a new Russian antihypertensive drug dilazin in surgery of the coronary arteries and abdominal aorta].
abstract: Dilazin in a dose of 0.2 mg/kg/min (n = 20) and 0.4 mg/kg/min (n = 20) was used to normalize arterial blood pressure during and after surgery. Intravenous infusion of the drug decreased the arterial pressure to baseline values within 2-3 min by reducing the elevated systemic vascular resistance. Dilazin did not affect the heart rate, mean pulmonary capillary wedge pressure, or central venous pressure. The drug brought about a marked increase of cardiac output and cardiac index. Prompt effect and easy control, when dilazin is infused in a dose of 0.2 to 0.4 mg/kg/min, recommend it as an alternative antihypertensive agent to be used during various procedures.
authors.forename: M N
authors.initials: MN
authors.lastname: Seleznev
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Gallinger
authors.forename: E V
authors.initials: EV
authors.lastname: Flerov
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000502:physiology / Q000627:therapeutic use*; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001012:Aorta, Abdominal / Q000601:surgery*; D001794:Blood Pressure / Q000187:drug effects; D003331:Coronary Vessels / Q000601:surgery*; D003627:Data Interpretation, Statistical; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D011182:Postoperative Care
chemical_list: D000959:Antihypertensive Agents; C109539:dilazin; D000241:Adenosine