title: Mortality in psychiatric hospital patients: a cohort analysis of prognostic factors.
abstract: BACKGROUND
  This work followed a group of patients living in a psychiatric hospital in Central Italy in 1978 at the time of enforcement of the Italian reform law (No. 180) for closing down mental hospitals. The study had the following aims: a) to compare in terms of mortality patients discharged into the community with patients who did not experience deinstitutionalization; b) to determine the survival of the cohort of patients and to analyse prognostic risk factors for death; c) to analyse differences in mortality rates between psychiatric patients and the general population.
  
  
  METHODS
  The study was designed as an historical follow-up investigation. Univariate (product limit) and multivariate (proportional hazards model) methods were used to estimate prognostic variables and related death risks. Mortality was assessed using standardized mortality ratios (SMR) on the entire cohort as well as after stratification according to age, sex, cause of death and discharge status, assuming the Abruzzo Region's population as standard.
  
  
  RESULTS
  Length of hospitalization and discharge from hospital are prognostic variables for death risk, with relative risks respectively of 4.22 (95% confidence interval [CI]: 2.41-7.40) for a length of hospitalization of 10-25 years, and 8.13 (95% CI: 4.73-13.88) for non-discharge. The global SMR of the cohort was 2.68 (95% CI: 2.42-3.07). Non-discharged patients showed higher SMR than discharged. Excess mortality was found both in males and females for circulatory, respiratory and undefined diseases. A significantly lower mortality for cancer was observed in male patients. A strong excess mortality was observed in younger patients (20-29 years: SMRmales = 43.57; SMRfemales = 97.52).
  
  
  CONCLUSIONS
  Longer periods of hospitalization and non-discharge from hospital are the main risk factors for death in psychiatric patients, who globally experience higher death rates than the general population for a wide spectrum of causes of death, whatever their diagnosis or gender. These findings strongly suggest positive actions in order to overcome the effects of institutionalization.
authors.affiliation: Epidemiological Research Centre, Faculty of Medicine, L'Aquila, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Valenti
authors.forename: S
authors.initials: S
authors.lastname: Necozione
authors.forename: G
authors.initials: G
authors.lastname: Busellu
authors.forename: G
authors.initials: G
authors.lastname: Borrelli
authors.forename: A R
authors.initials: AR
authors.lastname: Lepore
authors.forename: R
authors.initials: R
authors.lastname: Madonna
authors.forename: E
authors.initials: E
authors.lastname: Altobelli
authors.forename: A
authors.initials: A
authors.lastname: Mattei
authors.forename: P
authors.initials: P
authors.lastname: Torchio
authors.forename: G
authors.initials: G
authors.lastname: Corrao
authors.forename: F
authors.initials: F
authors.lastname: Di Orio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003688:Deinstitutionalization / Q000706:statistics & numerical data; D005260:Female; D006778:Hospitals, Psychiatric / Q000706:statistics & numerical data*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D001523:Mental Disorders / Q000401:mortality*; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate