Ultrasound stimulation of rat testes damaged by busulfan.
The purpose of the present study was to investigate whether or not low-intensity ultrasound exposure (20 mW/cm2 average intensity) accelerates the repair of rat germinal epithelium damaged by an antispermatogenic agent. The results from analysis of testicular weight and DNA content, sperm production and epididymal sperm concentration showed that the time needed for the reestablishment of the spermatogenic process following busulfan treatment was not reduced by ultrasound energy suggesting that, in contrast to many other mammalian tissues, the seminiferous epithelium is refractory to ultrasound stimulation.
Haddad
S
S
Department of Physiology, Faculty of Medicine of Ribeirão Preto, Brasil.
Carvalho
T L
TL
Anselmo-Franci
J A
JA
Petenusci
S O
SO
Favaretto
A L
AL
D000477:Alkylating Agents / Q000633:toxicity; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002066:Busulfan / Q000633:toxicity; D004247:DNA / Q000032:analysis; D004195:Disease Models, Animal; D004822:Epididymis / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D004848:Epithelium / Q000000981:diagnostic imaging / Q000473:pathology; D005640:Follicle Stimulating Hormone / Q000097:blood; D008297:Male; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count; D013091:Spermatogenesis; D013094:Spermatozoa / Q000502:physiology; D013733:Testicular Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D013737:Testis / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D014464:Ultrasonic Therapy; D014463:Ultrasonography
D000477:Alkylating Agents; D015415:Biomarkers; D005640:Follicle Stimulating Hormone; D004247:DNA; D002066:Busulfan