title: Survival after surgical treatment for primary hyperparathyroidism.
abstract: BACKGROUND
  Reports have suggested that patients with primary hyperparathyroidism (pHPT) are at increased risk for premature death, even when they reach normocalcemia. This study addresses factors that may be of relevance for long-term outcome.
  
  
  METHODS
  Between 1980 and 1984, 1052 patients (27% men and 73% women; median age, 59 years) underwent initial cervical exploration for pHPT. Long-term follow-up was obtained with regard to overall survival and cause of death. By using univariate and multivariate (Cox) survival analysis, subgroups of patients were compared.
  
  
  RESULTS
  Median follow-up was 12 years (range, 0 to 15 years). Overall, survival was not decreased compared with the expected survival of a gender- and age-matched midwest population. Survival was better in patients with a history of kidney stones (p = 0.044), without osteoporosis (p = 0.004), and without muscle weakness (p = 0.013).
  
  
  CONCLUSIONS
  Decreased long-term survival was not evident in this study. Age at the time of initial surgical treatment and the degree of endocrine activity of the diseased glands appear to be the most important independent prognostic factors for survival. Comparison of these data to prior Scandinavian data is not justified, principally because of the less advanced stage of disease in this study.
authors.affiliation: Division of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Söreide
authors.forename: J A
authors.initials: JA
authors.lastname: van Heerden
authors.forename: C S
authors.initials: CS
authors.lastname: Grant
authors.forename: C
authors.initials: C
authors.lastname: Yau Lo
authors.forename: C
authors.initials: C
authors.lastname: Schleck
authors.forename: D M
authors.initials: DM
authors.lastname: Ilstrup
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010281:Parathyroid Hormone / Q000097:blood; D015996:Survival Rate
chemical_list: D010281:Parathyroid Hormone