title: The nonstationary strain filter in elastography: Part I. Frequency dependent attenuation.
abstract: The accuracy and precision of the strain estimates in elastography depend on a myriad number of factors. A clear understanding of the various factors (noise sources) that plague strain estimation is essential to obtain quality elastograms. The nonstationary variation in the performance of the strain filter due to frequency-dependent attenuation and lateral and elevational signal decorrelation are analyzed in this and the companion paper for the cross-correlation-based strain estimator. In this paper, we focus on the role of frequency-dependent attenuation in the performance of the strain estimator. The reduction in the signal-to-noise ratio (SNRs) in the RF signal, and the center frequency and bandwidth downshift with frequency-dependent attenuation are incorporated into the strain filter formulation. Both linear and nonlinear frequency dependence of attenuation are theoretically analyzed. Monte-Carlo simulations are used to corroborate the theoretically predicted results. Experimental results illustrate the deterioration in the precision of the strain estimates with depth in a uniformly elastic phantom. Theoretical, simulation and experimental results indicate the importance of high SNRs values in the RF signals, because the strain estimation sensitivity, elastographic SNRe and dynamic range deteriorate rapidly with a decrease in the SNRs. In addition, a shift in the strain filter toward higher strains is observed at large depths in tissue due to the center frequency downshift.
authors.affiliation: Department of Radiology, University of Texas Medical School, Houston 77030, USA. tomyv@msrad3.med.uth.tmc.edu
authors.forename: T
authors.initials: T
authors.lastname: Varghese
authors.forename: J
authors.initials: J
authors.lastname: Ophir
mesh_terms: D003198:Computer Simulation; D004548:Elasticity; D005780:Gelatin; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008433:Mathematics; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D014465:Ultrasonics; D014463:Ultrasonography / Q000379:methods
chemical_list: D005780:Gelatin