Probabilities of identity-by-descent patterns in sibships when the parents are not genotyped.
An assumption-free algorithm has been applied to compute the probabilities of all possible identity-by-descent (IBD) configurations when the parents have not been genotyped. These probabilities can be used to determine the amount of information that a particular sibship will bring to a nonparametric linkage analysis. It is shown that the number of possible configurations can be extremely large even when the markers are closely spaced and are rather polymorphic. Further, it is not always possible to reduce this number to a manageable one simply by consideration of the relative probabilities of the configurations.
Todorov
A A
AA
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Siegmund
K D
KD
Gu
C
C
Borecki
I B
IB
Elston
R C
RC
D000465:Algorithms; D002878:Chromosomes, Human, Pair 1; D003198:Computer Simulation; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D009679:Nuclear Family; D010290:Parents; D011336:Probability; D011995:Recombination, Genetic; D018709:Statistics, Nonparametric
D005819:Genetic Markers