Expression of stromelysin-3 in medullary carcinoma of the breast.
Matrix metalloproteinases are belived to play a central role in the invasion and metastasis of human cancers by mediating the degration of extracellular matrix components. Expression of stromelysin-3 (ST3), a new member of matrix metalloproteinase family, was investigated by in situ hybridization in 32 tissue samples of medullary carcinoma of the breast. Eighty-four per cent of the cases showed ST3 gene expression in stromal cells adjacent to tumor cells. Therefore, expression of ST3 in stromal cells may be expected to play a significant role in the destruction of extracellular matrix and invasion of medullary carcinoma of the breast.
Holm
R
R
Department of Pathology, Norwegian Radium Hospital, Oslo, Norway.
Flørenes
V A
VA
Erikstein
B
B
Nesland
J M
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000201:enzymology*; D018276:Carcinoma, Medullary / Q000201:enzymology*; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D053507:Matrix Metalloproteinase 11; D008666:Metalloendopeptidases / Q000032:analysis*; D008875:Middle Aged; D012313:RNA / Q000032:analysis
D014408:Biomarkers, Tumor; D012313:RNA; D053507:Matrix Metalloproteinase 11; D008666:Metalloendopeptidases