title: Acute tubulointerstitial nephritis associated with piperacillin therapy in a boy with glomerulonephritis.
abstract: An 11-year-old boy with glomerulonephritis developed acute renal failure 4 days after beginning piperacillin (PIPC) treatment. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN) with marked eosinophils. A lymphocyte stimulation test (LST) for PIPC demonstrated an extremely high LST index of 626%. The serum levels of immunoglobulin E and eosinophil cationic protein also showed a significant increase at 9021 IU/mL and greater than 150 micrograms/L, respectively. These observations suggest that a hypersensitivity reaction might play a role in the pathogenesis of ATIN. This is the first report to describe PIPC-induced ATIN in a child.
authors.affiliation: Department of Pediatrics, Hirosaki University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Waga
authors.forename: Y
authors.initials: Y
authors.lastname: Kakizaki
authors.forename: T
authors.initials: T
authors.lastname: Tateyama
authors.forename: M
authors.initials: M
authors.lastname: Koda
authors.forename: M
authors.initials: M
authors.lastname: Yokoyama
mesh_terms: D000208:Acute Disease; D002648:Child; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D010406:Penicillins / Q000009:adverse effects*; D010878:Piperacillin / Q000009:adverse effects*
chemical_list: D010406:Penicillins; D010878:Piperacillin