title: Infusion clearance of subcutaneous iothalamate versus standard renal clearance.
abstract: Accurate, timed urine collections for the measurement of glomerular filtration rate (GFR) may be impractical in infants or in patients with urological abnormalities. GFR may be measured without urine collection using a constant subcutaneous infusion of iothalamate. We compare the infusion clearance with conventional renal clearance in 14 children and young adults. The mean clearance ratio (infusion clearance/renal clearance +/- 1 SD) was 0.99 +/- 0.1 and the mean discrepancy between the two methods was 8.5% +/- 4.7%. The 95% limits of agreement for the ratio of the two methods are 0.83-1.23. These data indicate that subcutaneous infusion of iothalamate is a practical method for measuring GFR in children without a urine collection.
authors.affiliation: Department of Pediatrics, Montreal Children's Hospital/McGill University, Quebec, Canada.
authors.forename: A K
authors.initials: AK
authors.lastname: Sharma
authors.forename: M S
authors.initials: MS
authors.lastname: Mills
authors.forename: V L
authors.initials: VL
authors.lastname: Grey
authors.forename: K N
authors.initials: KN
authors.lastname: Drummond
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007279:Injections, Subcutaneous; D007457:Iodine Radioisotopes; D007483:Iothalamic Acid / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism; D008297:Male
chemical_list: D003287:Contrast Media; D007457:Iodine Radioisotopes; D007483:Iothalamic Acid