Increased synthesis of cholesterol stearate in flanking organ from gonadectomized female hamsters treated with progesterone and 5 alpha-dihydroprogesterone.
We demonstrated for the first time that progesterone and 5 alpha-dihydroprogesterone stimulate [U-14C]glucose incorporation into lipids in gonadectomized female hamster flanking organs. We also found that cholesterol stearate is the major lipid synthesized female hamster flanking organs under progesterone and 5 alpha-dihydroprogesterone stimulation. In this manner, progesterone and 5 alpha-dihydroprogesterone alter the consistency of sebum from gonadectomized female glands.
Cabeza
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M
Department of Biological Systems, Metropolitan University Xochimilco, Mexico, D.F. Mexico.
Miranda
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R
D043582:5-alpha-Dihydroprogesterone; D000818:Animals; D002788:Cholesterol Esters / Q000096:biosynthesis*; D006224:Cricetinae; D005260:Female; D005947:Glucose / Q000378:metabolism; D010052:Ovariectomy; D011277:Pregnanediones / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*; D012627:Sebaceous Glands / Q000187:drug effects / Q000378:metabolism*; D013268:Stimulation, Chemical
D002788:Cholesterol Esters; D011277:Pregnanediones; C110341:cholesterol stearate; D011374:Progesterone; D043582:5-alpha-Dihydroprogesterone; D005947:Glucose