[Genotoxic effects of tonarol].
Genotoxic effects of 2,6-di-tret-butyl-4-methylphenol (tonarol) were studied using four test systems: the Ames test, the SOS chromotest, the cytogenetic test with rootlets of onion (Allium cepa), and the in vivo micronucleus test. Tonarol did not affect gene mutation induction in Salmonella typhimurium tester strains, the SOS response in the Escherichia coli strain PQ37, chromosomal aberrations in cells of onion (Allium cepa) rootlets, and micronuclei in erythrocytes of peripheral blood of CBA x C5713 L/G mice. Tonarol induced cell division in A.
Karamova
N S
NS
Il'inskaia
O N
ON
Ivanchenko
O B
OB
Ermolaev
A I
AI
Gil'mutdinov
G Z
GZ
Gershanov
F B
FB
Khamitov
B R
BR
D000490:Allium / Q000187:drug effects / Q000235:genetics; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D002869:Chromosome Aberrations; D004926:Escherichia coli / Q000235:genetics; D007621:Karyotyping; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D013014:SOS Response, Genetics; D012486:Salmonella typhimurium / Q000235:genetics
D009153:Mutagens; D002084:Butylated Hydroxytoluene