title: Comparison of evidence for linkage from different analytic methods.
abstract: In a randomly chosen replicate of extended pedigrees from GAW10, we conducted robust multipoint genome scans for linkage using a dense marker map. For analysis of the quantitative traits, we selected sibships from the pedigrees, and for analysis of disease status, small families of affected relatives were selected. Lod-score likelihood analyses were conducted in the full pedigrees and in the affected relative families for selected regions. We located a flanking marker for MG1 on chromosome 5, and identified marker regions including MG2, MG4, and MG5 on chromosomes 8 and 9. The analytic methods were consistent for the major gene with a strong effect; false positive errors on chromosomes 1 and 10 could have been eliminated by requiring evidence from more than one method.
authors.affiliation: Department of Preventive Medicine, University of Toronto, Ontario, Canada.
authors.forename: S B
authors.initials: SB
authors.lastname: Bull
authors.forename: D
authors.initials: D
authors.lastname: Pinnaduwage
authors.forename: J
authors.initials: J
authors.lastname: Shin
authors.forename: F
authors.initials: F
authors.lastname: Xie
authors.forename: D
authors.initials: D
authors.lastname: Tritchler
mesh_terms: D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D016555:Matched-Pair Analysis; D009679:Nuclear Family; D010375:Pedigree; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis
chemical_list: D005819:Genetic Markers