[Study of the treatment-prophylactic effect of immunomodulators in experimental infections, caused by Marburg, Ebola, and Venezuelan equine encephalitis viruses].
Therapeutic and prophylactic effects of immunomodifiers ridostin, reaferon, and polyribonate used alone and in various combinations were assessed in experiments on guinea pigs infected with Venezuelan equine encephalomyelitis (VEE) (strain Trinidad), Marburg (strain Popp), and Ebola (M/C-8 variant of Zaire strain) viruses at doses 5 to 20 respiratory LD50 through the respiratory airways. Urgent prophylactic simultaneous intramuscular and intranasal administration of ridostin protected the animals infected with Marburg virus (p = 0.1) and prolonged their life span by 2.4 days (p = 0.15). In Ebola infection a combination of ridostin and reaferon appreciably prolonged the mean life span: by 2.9 days (p = 0.04). In VEE ridostin alone or in combination with reaferone appreciably increased the share of survivors; ridostin with reaferon and polyribonate notably prolonged the mean life span of infected animals. None of these drugs or combinations produced an appreciable therapeutic effect in any of the studied infections.
Sergeev
A N
AN
Ryzhikov
A B
AB
Bulychev
L E
LE
Evtin
N K
NK
P'iankov
O V
OV
P'iankova
O G
OG
Slezkina
E I
EI
Kotliarov
L A
LA
Petrishchenko
V A
VA
Pliasunov
I V
IV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D004685:Encephalomyelitis, Venezuelan Equine / Q000188:drug therapy* / Q000517:prevention & control; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy* / Q000517:prevention & control; D007928:Lethal Dose 50; D008379:Marburg Virus Disease / Q000188:drug therapy* / Q000517:prevention & control
D000276:Adjuvants, Immunologic