title: Obliteration of a posttraumatic spinal cord cyst with solid human embryonic spinal cord grafts: first clinical attempt.
abstract: Cystic lesions of the spinal cord (syringomyelia) may occur after spinal cord injury. Posttraumatic syringomyelia may result in a myelopathy causing symptoms of sensory and motor loss, as well as worsening spasticity, pain, hyperhidrosis, and autonomic dysreflexia. Shunting of the cyst cavity along with untethering of the scarred spinal cord is widely accepted as the treatment of choice. However, the long-term stabilization of the progressive myelopathy caused by a posttraumatic cyst is suboptimal because of arachnoidal rescarring, shunt tube blockage, and cyst reexpansion. A new neurosurgical strategy to overcome the complication of cyst reexpansion was designed. Experimental studies have shown the successful use of embryonic spinal cord grafts, including human grafts, to obliterate induced spinal cord cavities in rats. The authors report the first use of solid human embryonic spinal cord grafts to successfully obliterate 6 cm of a large cyst cavity in a patient becoming myelopathic from a posttraumatic cyst. The grafts are well visualized by MRI to the 7-month postoperative follow-up and cyst obliteration is seen in the region where the grafts were placed.
authors.affiliation: Department of Neurosurgery, Craig Hospital, Denver, Colorado, USA.
authors.forename: S
authors.initials: S
authors.lastname: Falci
authors.forename: A
authors.initials: A
authors.lastname: Holtz
authors.forename: E
authors.initials: E
authors.lastname: Akesson
authors.forename: M
authors.initials: M
authors.lastname: Azizi
authors.forename: P
authors.initials: P
authors.lastname: Ertzgaard
authors.forename: C
authors.initials: C
authors.lastname: Hultling
authors.forename: A
authors.initials: A
authors.lastname: Kjaeldgaard
authors.forename: R
authors.initials: R
authors.lastname: Levi
authors.forename: O
authors.initials: O
authors.lastname: Ringden
authors.forename: M
authors.initials: M
authors.lastname: Westgren
authors.forename: D
authors.initials: D
authors.lastname: Lammertse
authors.forename: A
authors.initials: A
authors.lastname: Seiger
mesh_terms: D016332:Fetal Tissue Transplantation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009416:Nerve Regeneration; D013116:Spinal Cord / Q000473:pathology / Q000637:transplantation*; D013119:Spinal Cord Injuries / Q000150:complications; D013514:Surgical Procedures, Operative / Q000379:methods; D013595:Syringomyelia / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome