title: Mitomycin C and vinorelbine in pretreated breast cancer.
abstract: OBJECTIVE
  Vinorelbine, a new semi-synthetic vinca alkaloid, has demonstrated high activity as a single agent in pretreated metastatic breast cancer.
  
  
  METHODS
  To evaluate the activity of the combination vinorelbine-mitomycin C and to reduce the incidence of side effects, in particular myelotoxicity, patients with metastatic breast cancer pretreated with 1 or more chemotherapy regimens for metastatic disease were treated according to the following schedule: mitomycin C, 10 mg/m2 day 1, and vinorelbine, 25 mg/m2, days 1, 8 and 15, every 28 days.
  
  
  RESULTS
  Twenty-seven patients were enrolled and were evaluable for activity and side effects. A total of 157 cycles were delivered (median 5 cycles per patient). There were 10 partial remissions (37%; 95% confidence interval 20-59%), 5 instances of stable disease and 12 of disease progression. Grade III-IV toxicity was mostly hematological and included thrombocytopenia (4%) and neutropenia (42%).
  
  
  CONCLUSIONS
  Our results indicate that the combination of mitomycin C and vinorelbine has moderate activity in pretreated breast cancer.
authors.affiliation: Division of Medical Oncology, Ospedale Castelfranco Veneto, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Colleoni
authors.forename: P
authors.initials: P
authors.lastname: Manente
authors.forename: J
authors.initials: J
authors.lastname: Stocker
authors.forename: H
authors.initials: H
authors.lastname: Amor
authors.forename: S
authors.initials: S
authors.lastname: Lamon
authors.forename: P
authors.initials: P
authors.lastname: Nelli
authors.forename: G
authors.initials: G
authors.lastname: Vicario
authors.forename: G
authors.initials: G
authors.lastname: Sgarbossa
authors.forename: C
authors.initials: C
authors.lastname: Graiff
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D016685:Mitomycin; D014747:Vinblastine; D000077235:Vinorelbine