title: Clinicopathologic correlations of soluble amyloid beta-protein precursor in cerebrospinal fluid in patients with Alzheimer disease and controls.
abstract: The authors compared concentrations of soluble beta-amyloid protein precursor (s beta PP) in cerebrospinal fluid (CSF) in 45 patients diagnosed with probable Alzheimer disease (AD) and 26 normal older control volunteers. Soluble beta-amyloid protein precursor concentrations were measured in 125 CSF samples using an enzyme-linked immunosorbent assay. All subjects had Mini-Mental State Examination (MMSE) and Clinical Dementia Rating Scale (CDRS) scores and assessment of disease duration. The s beta PP concentrations in CSF in the probable AD group (mean +/- SD = 493 +/- 268 micrograms/L) were decreased significantly compared with the age-matched control group (mean = 831 +/- 302 micrograms/L; p < 0.0001). In the probable AD group, MMSE scores correlated positively with s beta PP concentrations (correlation coefficient r = 0.53, p < 0.0001), and CDRS ratings and disease duration correlated inversely with s beta PP concentrations (r = -0.59, p < 0.0001 and r = -0.479, p = 0.0006, respectively). Although the decrease in CSF s beta PP from levels found in healthy elderly controls was significant in AD subjects, there was substantial overlap. In AD, CSF s beta PP was most reduced in patients in later stages of the disease. The s beta PP concentrations reflect disease severity, but utility in differential diagnosis has not been determined.
authors.affiliation: Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Peskind
authors.forename: J
authors.initials: J
authors.lastname: Leverenz
authors.forename: M R
authors.initials: MR
authors.lastname: Farlow
authors.forename: R K
authors.initials: RK
authors.lastname: Ito
authors.forename: S A
authors.initials: SA
authors.lastname: Provow
authors.forename: R S
authors.initials: RS
authors.lastname: Siegel
authors.forename: M
authors.initials: M
authors.lastname: Cleveland
authors.forename: C H
authors.initials: CH
authors.lastname: Morgan
authors.forename: M R
authors.initials: MR
authors.lastname: Pandian
authors.forename: S
authors.initials: S
authors.lastname: Corbin
authors.forename: D
authors.initials: D
authors.lastname: Nochlin
authors.forename: G D
authors.initials: GD
authors.lastname: Schellenberg
authors.forename: M A
authors.initials: MA
authors.lastname: Raskind
authors.forename: S L
authors.initials: SL
authors.lastname: Wagner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000523:psychology; D016564:Amyloid beta-Protein Precursor / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D012995:Solubility
chemical_list: D016564:Amyloid beta-Protein Precursor