title: "Multidimensionally impaired disorder": is it a variant of very early-onset schizophrenia?
abstract: OBJECTIVE
  To examine the validity of diagnostic criteria for a subgroup of children with atypical psychosis (n = 19), designated here as "multidimensionally impaired." These children are characterized by poor attention and impulse control, psychotic symptoms, and poor affective control.
  
  
  METHODS
  Children and adolescents (n = 19) meeting our criteria for multidimensionally impaired syndrome with onset of psychotic symptoms at or before age 12 years were identified from a total of 150 in-person screenings for very early-onset schizophrenia between 1990 and 1996. We compared the premorbid adjustment, family history, follow-up status, and laboratory measures for a subgroup of these children with those of (1) a rigorously defined group of 29 children with DSM-III-R schizophrenia and (2) 19 children with attention-deficit hyperactivity disorder.
  
  
  RESULTS
  Patients with multidimensionally impaired syndrome and patients with very early-onset schizophrenia shared a similar pattern of early transient autistic features, postpsychotic cognitive decline, and an elevated risk of schizophrenic-spectrum disorders among their first-degree relatives. This pattern was not seen in the attention-deficit hyperactivity disorder group. In contrast to very early-onset schizophrenia, the multidimensionally impaired group had significantly poorer scores on the Freedom From Distractibility factor on the WISC-R, a less deviant pattern of autonomic reactivity, and no progression to schizophrenia.
  
  
  CONCLUSIONS
  The findings support the distinction of the multidimensionally impaired cases as separate from those with other psychiatric disorders, and there is somewhat greater evidence to suggest that this disorder belongs in the schizophrenia spectrum.
authors.affiliation: Child Psychiatry Branch, NIMH, Bethesda, MD 20892-1600, USA.
authors.forename: S
authors.initials: S
authors.lastname: Kumra
authors.forename: L K
authors.initials: LK
authors.lastname: Jacobsen
authors.forename: M
authors.initials: M
authors.lastname: Lenane
authors.forename: T P
authors.initials: TP
authors.lastname: Zahn
authors.forename: E
authors.initials: E
authors.lastname: Wiggs
authors.forename: J
authors.initials: J
authors.lastname: Alaghband-Rad
authors.forename: F X
authors.initials: FX
authors.lastname: Castellanos
authors.forename: J A
authors.initials: JA
authors.lastname: Frazier
authors.forename: K
authors.initials: K
authors.lastname: McKenna
authors.forename: C T
authors.initials: CT
authors.lastname: Gordon
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Hamburger
authors.forename: J L
authors.initials: JL
authors.lastname: Rapoport
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000145:classification*; D001321:Autistic Disorder / Q000145:classification*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002665:Child Psychiatry; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000453:epidemiology*; D012561:Schizophrenia, Childhood / Q000145:classification*; D013577:Syndrome; D009626:Terminology as Topic; D014481:United States / Q000453:epidemiology