Neurological manifestations of perinatally acquired HIV-1 infection.
Infection with the human immunodeficiency virus type 1 (HIV-1) remains a major potential cause of neurological disorders in children and adults throughout the world. This article provides an overview regarding the epidemiology, clinical manifestations, and neuropathogenesis of perinatally acquired HIV-1 infection. Insights regarding the mechanisms of neuroinvasion and neuropathogenesis may allow novel strategies for treating or preventing the devastating consequences of HIV-1 infection of the central nervous system (CNS).
Epstein
L G
LG
Division of Child Neurology, University of Rochester Medical Center, NY 14642, USA.
Sharer
L R
LR
D015526:AIDS Dementia Complex / Q000209:etiology*; D000328:Adult; D002494:Central Nervous System Infections / Q000151:congenital*; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000151:congenital*; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn