[Estrogen replacement therapy: myth or reality?].
Before 50, women are protected against cardio-vascular diseases, and this protection disappears after this age. There are some strong epidemiologic arguments to attribute this loss of protection to the menopause. The ways of action of this hormonal shortage are still being discussed. Hypercholesterolemia seems to be a less important factor than with men, but signs of insulin resistance (hypertriglyceridemia, hypoHDLemia, androïd morphotype) play an important part. Estrogen HRT lowers coronarien risk, but published results are optimized by good health effect. Progestins do no affect results. The ways of action of estrogens are multiple. Some molecules and ways of administration have deleterious effects, the consequences of which are not known, in particular among patients with risk factors who would be the first to benefit from a preventive effect.
Jamin
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D003327:Coronary Disease / Q000517:prevention & control*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects* / Q000502:physiology; D012307:Risk Factors