Age-associated changes in Ca(2+)-dependent processes: relation to hippocampal synaptic plasticity.
Altered calcium (Ca2+) homeostasis is thought to play a key role in aging and neuropathology resulting in memory deficits. Several forms of hippocampal synaptic plasticity are dependent on Ca2+, providing a potential link between altered Ca2+ homeostasis and memory deficits associated with aging. The current study reviews evidence for Ca2+ dysregulation during aging which could interact with Ca(2+)-dependent synaptic plasticity. The authors suggest that changes in Ca2+ regulation could adjust the thresholds for synaptic modification, favoring processes for depression of synaptic strength during aging.
Foster
T C
TC
Department of Psychology, University of Virginia, Charlottesville 22903, USA. TCF5A@Virginia.EDU
Norris
C M
CM
D000375:Aging / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D002118:Calcium