[Endocrine and exocrine gastric mucosal secretion in the course of H. pylori eradication in patients with non-ulcer dyspepsia].
Microstructural, endo- and exocrine changes in gastric mucosa of Non-Ulcer Dyspepsia patients with H. pylori infection in the course of eradication has been studied. Before, during and after anti H. pylori therapy plasma gastrin and somatostatin levels, EGF and somatostatin concentration in gastric juice and basal and pentagastrin stimulated gastric acid secretion were measured. Moreover microstructure of gastric mucosa specimens has been studied. Maximal Acid Output initially higher in NUD patients than in healthy volunteers increased slightly in the course of eradication. Plasma gastrin decreased while EGF and somatostatin concentration in gastric juice increased. After treatment the ratio of patients with pronounced features (activity) of gastritis was significantly reduced.
Bobrzyński
A
A
II Katedry i Kliniki Chirurgii Ogólnej, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Gedliczka
O
O
Bielański
W
W
Stachura
J
J
Konturek
S
S
Budzyński
A
A
D000658:Amoxicillin / Q000008:administration & dosage; D001729:Bismuth / Q000008:administration & dosage; D004415:Dyspepsia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000032:analysis; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000187:drug effects; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000378:metabolism*; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D009853:Omeprazole / Q000008:administration & dosage; D013004:Somatostatin / Q000097:blood / Q000187:drug effects; D013276:Stomach Ulcer / Q000150:complications
D005755:Gastrins; D008795:Metronidazole; D013004:Somatostatin; D004815:Epidermal Growth Factor; D000658:Amoxicillin; D009853:Omeprazole; D001729:Bismuth