Normal human B cell sub-populations and their malignant counterparts.
Seven tonsillar B cell sub-sets have been isolated according to cell surface molecular markers. The molecular characteristics of their phenotype, cell cycle, survival, somatic mutations and isotype switch status permit their inter-relationships to be followed up until the plasma cell stage. Different lymphoma types correlate with all except one of the stages and only two out of nine non-Hodgkin's B cell lymphomas cannot be presently associated to a normal peripheral B cell sub-set. The assignment of lymphomas to their normal human B cell counterparts will facilitate the identification of the causative event(s) responsible for the malignant transformation.
Pascual
V
V
Department of Pediatrics, University of Texas, Dallas 75235, USA.
Liu
Y J
YJ
Banchereau
J
J
D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D019337:Hematologic Neoplasms / Q000145:classification* / Q000276:immunology; D006801:Humans; D015448:Leukemia, B-Cell / Q000276:immunology; D016393:Lymphoma, B-Cell / Q000276:immunology
D015415:Biomarkers