title: Two cases of musculoskeletal syndrome associated with acne.
abstract: We report two cases of musculoskeletal syndrome (myalgia, arthralgia, arthritis, hyperostosis) that developed in male adolescents who had severe acne (acne conglobata and acne fulminans). In both patients the hyperostosis of the right clavicle aroused the suspicion of a bone tumor or osteomyelitis, which was excluded by histologic examination. Radiologic and laboratory characteristics of musculoskeletal syndrome associated with acne conglobata and acne fulminans are reviewed as well as isotretinoin therapy. The problems of differential diagnosis are also discussed.
authors.affiliation: Department of Paediatrics, University Medical School of Pécs, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Erhardt
authors.forename: F
authors.initials: F
authors.lastname: Harangi
mesh_terms: D000152:Acne Vulgaris / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000293:Adolescent; D018771:Arthralgia / Q000209:etiology; D001168:Arthritis / Q000209:etiology; D003937:Diagnosis, Differential; D006801:Humans; D015576:Hyperostosis / Q000209:etiology; D015474:Isotretinoin / Q000009:adverse effects; D008297:Male; D009140:Musculoskeletal Diseases / Q000175:diagnosis / Q000209:etiology*; D013577:Syndrome
chemical_list: D015474:Isotretinoin