The photogenotoxicity of titanium dioxide particles.
We employed a series of in vitro genotoxicity assays--a single cell gel (SCG) assay with mouse lymphoma L5178Y cells, a microbial mutation assay with Salmonella typhimurium, a mammalian cell mutation assay with L5178Y cells, and a chromosomal aberration assay with Chinese hamster CHL/IU cells--to evaluate the photogenotoxicity of titanium dioxide (TiO2) particles. Without UV/visible light irradiation, TiO2 particles exhibited no or weak genotoxicity. With irradiation, however, TiO2 particles exhibited significant genotoxicity in the SCG and chromosomal aberration assays. Therefore, we concluded that TiO2 particles are photogenotoxic.
Nakagawa
Y
Y
Laboratory of Cellular Toxicology, Hatano Research Institute, Food and Drug Safety Center, Kanagawa, Japan.
Wakuri
S
S
Sakamoto
K
K
Tanaka
N
N
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D008027:Light; D051379:Mice; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000235:genetics; D014025:Titanium / Q000633:toxicity*; D014407:Tumor Cells, Cultured
C009495:titanium dioxide; D014025:Titanium