title: Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.
abstract: Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxic isoplumericin and plumericin. In addition, the new lignan 7(R)-methoxy-8-epi-matairesional and three known compounds, plumieride, matairesinol, and pinoresinol, were isolated from H. fallax.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061-0212, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Abdel-Kader
authors.forename: J
authors.initials: J
authors.lastname: Wisse
authors.forename: R
authors.initials: R
authors.lastname: Evans
authors.forename: H
authors.initials: H
authors.lastname: van der Werff
authors.forename: D G
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013141:Spiro Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D013532:Suriname; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D017705:Lignans; D013141:Spiro Compounds; C110080:plumieride; C068935:matairesinol; C103298:pinoresinol