Involvement of an efflux system in high-level fluoroquinolone resistance of Shigella dysenteriae.
Shigella dysenteriae represent one of the growing list of antibiotic-resistant bacteria. Quinolones are widely employed to treat shigellosis. However, quinolone resistance has already been reported, necessitating an understanding of the mechanisms of development of resistance. We demonstrate that high-level fluoroquinolone resistance of S. dysenteriae exposed to these antibiotics may occur in the absence of gyrA mutations and involve a proton motive force(pmf)-dependent efflux system.
Ghosh
A S
AS
Department of Chemistry, Bose Institute, Calcutta, India.
Ahamed
J
J
Chauhan
K K
KK
Kundu
M
M
D000900:Anti-Bacterial Agents / Q000378:metabolism; D000890:Anti-Infective Agents / Q000378:metabolism / Q000494:pharmacology*; D001692:Biological Transport; D002463:Cell Membrane Permeability; D002701:Chloramphenicol / Q000378:metabolism; D002939:Ciprofloxacin / Q000378:metabolism; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II / Q000235:genetics; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D012762:Shigella dysenteriae / Q000187:drug effects*; D013752:Tetracycline / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D002701:Chloramphenicol; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II; D013752:Tetracycline