Synthesis of 2-[4-(4-iodophenyl)-1-piperazinylmethyl]-1,3,4-oxadiazole and its potential application in the indirect iodination of carbonyl compounds.
The synthesis of 2-[4-(4-iodophenyl)-1-piperazinylmethyl]- 1,3,4-oxadiazole is discussed. Hydrolysis of the oxadiazole followed by condensation with 3 beta-hydroxy-5-androsten-17-one gave the hydrazone. This synthetic sequence could be applied for the indirect iodination/radioiodination of ketosteroids.
Hassan
M A
MA
Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
Shabsoug
B M
BM
D003687:Dehydroepiandrosterone; D007202:Indicators and Reagents; D007455:Iodine; D007457:Iodine Radioisotopes; D010069:Oxadiazoles / Q000138:chemical synthesis*; D010879:Piperazines / Q000138:chemical synthesis*; D011865:Radioisotope Dilution Technique
C110497:2-(4-(4-iodophenyl)-1-piperazinylmethyl)-1,3,4-oxadiazole; D007202:Indicators and Reagents; D007457:Iodine Radioisotopes; D010069:Oxadiazoles; D010879:Piperazines; D003687:Dehydroepiandrosterone; D007455:Iodine