[Enzymes in gastric juice. An aid in the diagnosis of gastric cancer].
In the present study we measured the activities of the following enzymes: LDH (lactic dehydrogenase), beta-glucuronidase, acid maltase, phosphohexoseisomerase (PHI) and acid proteases in the gastric juice of patients with gastric cancer (n = 50) (Case Group), in endoscopically normal subjects (n = 50) and in subjects with different non tumor-like digestive pathologies (n = 55) (Control Groups). In the patients with gastric carcinoma we found a significant increase in LDH, beta-glucuronidase, PHI and acid maltase activities and a decreased activity of acid proteases. The results agree with previous findings from other workers. The variations of enzyme activities in gastric juice can help to differentiate between malignant and benign processes of the gastric mucosa.
Marino Alarcón
O
O
Laboratorio de Bioquímica Nutricional, Escuela de Nutrición y Dietética, Mérida, Venezuela.
Concho Lugo
H
H
Silva Larralte
T
T
Tauil Bsereni
E
E
Solano Nava
P
P
Machado
D
D
Chacón Patiño
A
A
D000230:Adenocarcinoma / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016022:Case-Control Studies; D004796:Clinical Enzyme Tests; D005260:Female; D005750:Gastric Juice / Q000201:enzymology*; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000175:diagnosis*
D007770:L-Lactate Dehydrogenase; D006026:Glycoside Hydrolases; D005956:Glucose-6-Phosphate Isomerase