title: The movement of tRNA through the ribosome.
abstract: The interaction between tRNA and the ribosome during translation, specifically during elongation, constitutes an example of the motion and adaptability of living molecules. Recent results obtained by cryoelectron microscopy of "naked" ribosomes and ribosomes in functional binding states shine some light on this fundamental life-sustaining process. Inspection of the surface contour of our reconstruction reveals a precise "lock-and-key" fit between the intersubunit space and the tRNA molecule.
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany 12201-0509, USA. joachim@wadsworth.org
authors.forename: J
authors.initials: J
authors.lastname: Frank
authors.forename: R K
authors.initials: RK
authors.lastname: Agrawal
mesh_terms: D001665:Binding Sites; D046911:Macromolecular Substances; D008958:Models, Molecular; D008961:Models, Structural; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure*; D012270:Ribosomes / Q000378:metabolism* / Q000648:ultrastructure*
chemical_list: D046911:Macromolecular Substances; D012333:RNA, Messenger; D012343:RNA, Transfer