title: STAR, a gene family involved in signal transduction and activation of RNA.
abstract: A new subfamily of KH-domain-containing RNA-binding proteins is encoded by genes that are conserved from yeast to humans. Mutations with interesting developmental phenotypes have been identified in Caenorhabditis elegans, Drosophila and mouse. It is hypothesized that these bifunctional proteins provide a rich source of interesting molecular information about development and define a new cellular pathway that links signal transduction directly to RNA metabolism.
authors.affiliation: Cell and Molecular Biology Institute, University of Texas at Austin 78712-1064, USA. vernet@uts.cc.utexas.edu
authors.forename: C
authors.initials: C
authors.lastname: Vernet
authors.forename: K
authors.initials: K
authors.lastname: Artzt
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D015801:Helminth Proteins / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D008969:Molecular Sequence Data; D009154:Mutation; D009687:Nuclear Proteins; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D000072260:RNA Splicing Factors; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014157:Transcription Factors
chemical_list: D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; C489560:DOK1 protein, human; C489561:Dok1 protein, mouse; D029721:Drosophila Proteins; C074561:GAP-associated protein p62; C094448:GLD-1 protein, C elegans; D015801:Helminth Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; C490832:QKI protein, human; C098217:Qk protein, mouse; D000072260:RNA Splicing Factors; D016601:RNA-Binding Proteins; C491517:SF1 protein, Drosophila; C491514:Sf1 protein, mouse; D014157:Transcription Factors; C106296:how protein, Drosophila; C491515:sfa-1 protein, C elegans; D012313:RNA