title: Finite element aided tracking of signal intensity changes in deforming intervertebral disc tissue.
abstract: Tracking of signal intensity changes in soft tissue over time is often hampered by deformation of the tissue. In this study a method is described that uses finite element modeling to compensate for tissue deformation. The method is applied to the quantification of fluid redistribution in an intervertebral disc that deforms under mechanical load. The clinical importance of this application emerges from the increased susceptibility of the intervertebral disc to damage after a period of mechanical loading. The study shows that the use of the finite element aided approach results in a detailed map of tissue MRI signal changes, where the distorting effects of tissue deformation are eliminated.
authors.affiliation: Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands. I_KINGMA@FBW.VU.NL
authors.forename: I
authors.initials: I
authors.lastname: Kingma
authors.forename: H
authors.initials: H
authors.lastname: Weinans
authors.forename: J H
authors.initials: JH
authors.lastname: van Dieën
authors.forename: R W
authors.initials: RW
authors.lastname: de Boer
mesh_terms: D000818:Animals; D007403:Intervertebral Disc / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D008962:Models, Theoretical; D013314:Stress, Mechanical; D013552:Swine