title: Autoimmune prostatitis: evidence of T cell reactivity with normal prostatic proteins.
abstract: OBJECTIVE
  To determine whether men with chronic prostatitis/chronic pelvic pain syndrome have evidence of an autoimmune response to prostatic proteins. We examined men with a history of chronic prostatitis/ chronic pelvic pain syndrome for evidence of T lymphocyte reactivity to seminal plasma.
  
  
  METHODS
  Patients underwent automated leukopheresis to obtain peripheral blood mononuclear cells. We performed a recall antigen proliferation assay to detect specific proliferation of peripheral helper T lymphocytes in men. with chronic prostatitis/chronic pelvic pain syndrome and compared the results with those of normal men. The antigen for these studies consisted of seminal plasma from normal donors and men with seminal vesicle atresia.
  
  
  RESULTS
  A specific recall proliferative response to seminal plasma was observed in 3 of 10 men with a history of chronic prostatitis/chronic pelvic pain syndrome compared with none of 15 normal men. The CD4 T cell proliferative response to seminal plasma was statistically significant when compared with medium alone in men with a history of chronic prostatitis/chronic pelvic pain syndrome but it was not statistically significant in normal men. The recall responses of both the chronic prostatitis/chronic pelvic pain syndrome group and normal subjects to the recall antigens tetanus toxoid and Candida extract were equivalent.
  
  
  CONCLUSIONS
  The data represent the first direct evidence that some men with chronic prostatitis/chronic pelvic pain syndrome have an autoimmune component to their disease. Autoimmunity is a potential etiology for chronic nonbacterial prostatitis.
authors.affiliation: Urology Section, VA Maryland Health Care System, Baltimore 21201, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Alexander
authors.forename: F
authors.initials: F
authors.lastname: Brady
authors.forename: S
authors.initials: S
authors.lastname: Ponniah
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D002908:Chronic Disease; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D017699:Pelvic Pain / Q000209:etiology / Q000276:immunology; D010865:Pilot Projects; D011467:Prostate / Q000276:immunology*; D011472:Prostatitis / Q000209:etiology / Q000276:immunology*; D011506:Proteins / Q000276:immunology*; D012661:Semen / Q000276:immunology; D018709:Statistics, Nonparametric; D013577:Syndrome
chemical_list: D011506:Proteins