Factors influencing the identification of major genes in a complex disease genome scan.
A two-stage linkage strategy was employed to identify major genes for a simulated complex disease via a genome scan. The importance of several approaches for improving the ability to locate major genes has been illustrated. These approaches are: adjusting for covariates, ascertaining through multiple affected family members, increasing the sample size, and using multipoint linkage analysis.
Yang
H
H
Division of Medical Genetics, Cedars-Sinai Research Institute, School of Medicine, UCLA, USA.
Wang
Y
Y
Goldstein
D R
DR
Li
Z
Z
Vora
H
H
Cantor
R M
RM
D002874:Chromosome Mapping / Q000379:methods; D002895:Chromosomes, Human, Pair 5; D003198:Computer Simulation; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D015894:Genome, Human; D006801:Humans; D011237:Predictive Value of Tests; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis; D012307:Risk Factors; D018401:Sample Size
D005819:Genetic Markers