Severe acute liver failure as the initial manifestation of haematological malignancy.
Acute liver failure is rarely secondary to lymphoma or leukaemia and it is extremely uncommon as the initial presentation of malignancy. We report a case of a young adult patient with severe acute liver failure referred for liver transplant, in which a Burkitt acute lymphoblastic leukaemia was diagnosed by bone marrow examination. A complete recovery and long remission were obtained with chemotherapy.
Souto
P
P
Department of Gastroenterology, Coimbra University Hospital, Portugal.
Romãozinho
J M
JM
Figueiredo
P
P
Ferreira
M
M
Sousa
I
I
Camacho
E
E
Donato
A
A
Freitas
D
D
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002051:Burkitt Lymphoma / Q000175:diagnosis* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006529:Hepatomegaly / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D017114:Liver Failure, Acute / Q000175:diagnosis* / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate