Bipolar disorder and chromosome 18: an analysis of multiple data sets.
There have been conflicting reports of linkage between bipolar disorder and chromosome 18. We have analyzed five separate data sets using the two-point affected sib-pair method and family based association methods. We have found evidence of linkage in multiple data sets and differences in maternal and paternal allele sharing. Suggestive, though nonsignificant, evidence of linkage disequilibrium of two tightly linked markers has also been demonstrated in multiple data sets.
Badner
J A
JA
National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
Goldin
L R
LR
D001714:Bipolar Disorder / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18; D002895:Chromosomes, Human, Pair 5; D003627:Data Interpretation, Statistical; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male
D005819:Genetic Markers