title: Cowden's disease--a report on the first case in Korea and literature review.
abstract: Cowden's disease, or multiple hamartoma syndrome, is an uncommon condition with characteristic mucocutaneous lesions associated with abnormalities of the breast, thyroid, and gastrointestinal tract. We describe a 32-year-old man with oral mucosal papillomatosis and plantar hyperkeratosis as a definite case of Cowden's disease according to the criteria proposed by Salem and Steck. The patient also had a thyroid mass and numerous gastrointestinal polyps endoscopically. Histologically the polyps were hamartomatous or hyperplastic polyps. The oral papillary lesions were fibroepithelial polyps and the thyroid mass was a follicular adenoma. We review the literature on this entity and summarize the pertinent findings. To the best of our knowledge, this is the first documented case of Cowden's disease in a Korean.
authors.affiliation: Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: H R
authors.initials: HR
authors.lastname: Lee
authors.forename: Y S
authors.initials: YS
authors.lastname: Moon
authors.forename: C H
authors.initials: CH
authors.lastname: Yeom
authors.forename: K W
authors.initials: KW
authors.lastname: Kim
authors.forename: J Y
authors.initials: JY
authors.lastname: Chun
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Choi
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: T S
authors.initials: TS
authors.lastname: Chung
mesh_terms: D000328:Adult; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007417:Intestinal Polyps / Q000473:pathology; D007645:Keratoderma, Palmoplantar / Q000473:pathology; D007723:Korea / Q000453:epidemiology; D008297:Male; D010212:Papilloma / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology; D014062:Tongue Neoplasms / Q000473:pathology