Platelet antigen allele frequencies in Australian aboriginal and Caucasian populations.
We have applied genotyping methods of PCR-SSOP and PCR-RFLP to three, bi-allelic platelet specific antigen systems HPA-1 (Pla), HPA-3 (Bak) and HPA-5 (Br). This combination of techniques offers flexibility for high volume or rapid typing. The phenotype and genotype frequencies of alleles from the three systems differ significantly between the Yuendumu Australian Aboriginals (Wailbri) and Australian Caucasians. The major differences are the very low frequencies of HPA-1b and HPA-3b in Yuendumu Aboriginals which are potentially relevant to platelet transfusion in patients of Australian Aboriginal descent.
Chen
Z
Z
Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia.
Lester
S
S
Boettcher
B
B
McCluskey
J
J
D000483:Alleles; D016824:Antigens, Human Platelet / Q000235:genetics*; D001315:Australia; D000939:Epitopes / Q000235:genetics; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D039661:Integrin beta3; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D044465:White People / Q000235:genetics*
C044561:3a alloantigen, human; C071092:5a alloantigen, human; D016824:Antigens, Human Platelet; D000939:Epitopes; C061248:ITGB3 protein, human; D039661:Integrin beta3