Resection of hepatic and pulmonary metastases in patients with colorectal carcinoma.
BACKGROUND
Surgical resection of hepatic or pulmonary metastases has been accepted as appropriate therapy. However, whether aggressive surgery of both hepatic and pulmonary metastases from colorectal carcinoma is of value has not been verified in detail.


METHODS
The authors identified 156 patients who had undergone hepatic resection for colorectal carcinoma metastases. This study reviewed six of these patients who underwent resection of both hepatic and pulmonary metastases from colorectal carcinoma.


RESULTS
Five of the patients included four who underwent pulmonary resection for pulmonary metastases after initial hepatic resection for hepatic metastases and one patient who underwent hepatic metastasis resection after initial pulmonary metastasis resection. One additional patient underwent a simultaneous resection of hepatic and pulmonary metastases. The median interval between the 2 resections was 23 months. The median follow-up was 32 months after the second resection. At the time of last follow-up, 4 patients were alive and free of recurrent disease at 6, 7, 38, and 64 months, respectively, after their second resection. The remaining 2 patients died of disease at 17 and 32 months, respectively, after the second surgery.


CONCLUSIONS
The results of the current study suggest that hepatic and pulmonary resection can result in long term survival in select patients with hepatic and pulmonary metastases from colorectal carcinoma because surgery remains the only potentially curative treatment.
Ambiru
S
S
The First Department of Surgery, Chiba University School of Medicine, Japan.
Miyazaki
M
M
Ito
H
H
Nakagawa
K
K
Shimizu
H
H
Kato
A
A
Nakamura
S
S
Omoto
H
H
Nakajima
N
N
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D002423:Cause of Death; D003110:Colonic Neoplasms / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D011013:Pneumonectomy; D012004:Rectal Neoplasms / Q000601:surgery*; D015996:Survival Rate; D013997:Time Factors