title: Fixed drug eruption caused by tosufloxacin tosilate.
abstract: A 39-year-old woman presented with a purple-red macula, 2 cm in diameter, on the back of her right hand. She had had similar maculae at this location several times before and residual pigmentation had persisted for 6 months. Histopathological examination showed slight acanthosis of the epidermis and perivascular round-cell infiltration and melanophages in the dermis. Oral provocation tests with five drugs that the patient had received as common-cold treatments on different occasions were positive only in the case of tosufloxacin; after an hour the skin lesion reappeared. To our knowledge this is the first published report of a fixed drug eruption caused by tosufloxacin, although such eruptions have previously been reported for several other fluoroquinolones.
authors.affiliation: Division of Dermatology, Kori Branch Hospital, Kansai Medical University, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nishijima
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D003139:Common Cold / Q000188:drug therapy; D003875:Drug Eruptions / Q000175:diagnosis* / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D005260:Female; D024841:Fluoroquinolones; D006225:Hand; D006801:Humans; D008548:Melanosis / Q000139:chemically induced / Q000473:pathology; D009287:Naphthyridines / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C055185:tosufloxacin