Detection of EBV RNA (EBER-1 and EBER-2) in malaria lymph nodes by in situ hybridization.
Acute Plasmodium falciparum malaria in African children allows expansion of latent Epstein-Barr virus infection, leading to colonization of lymph nodes by virus-infected lymphoblasts in 60% of cases as demonstrated by in situ hybridization for the detection of EBER-1 and EBER-2 RNA. This probably arises against a background of malaria-induced immunosuppression to EBV and concurrent lymphoid activation. The relevance of the results to the pathogenesis of African endemic Burkitt's lymphoma is discussed.
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Department of Haematology, St. Bartholomew's, London, U.K.
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D000818:Animals; D002051:Burkitt Lymphoma / Q000209:etiology* / Q000473:pathology / Q000821:virology; D002163:Cameroon; D002675:Child, Preschool; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology; D006801:Humans; D017403:In Situ Hybridization; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology*; D016778:Malaria, Falciparum / Q000150:complications*; D008297:Male; D015345:Oligonucleotide Probes; D010963:Plasmodium falciparum / Q000502:physiology; D012367:RNA, Viral / Q000032:analysis*; D014068:Tonsillectomy
D015345:Oligonucleotide Probes; D012367:RNA, Viral