title: Sinusitis and asthma: how do they interrelate in sinus surgery?
abstract: Sinusitis has been suspected to be etiopathogenically linked to bronchial asthma. Asthma, on the other hand, has been reported to affect negatively the outcome of sinus surgery. The purpose of this study is to elucidate how sinusitis and asthma clinically interrelate, in a group of asthmatic subjects undergoing surgical interventions on the sinuses. A total of 43 asthmatic patients, selected for functional endoscopic sinus surgery, preoperatively had their sinus disease staged and their lung function tested, and were evaluated for allergy and aspirin sensitivity. One year after surgery the surgical results were analyzed, lung function was re-assessed, and patients' clinical status addressed through a questionnaire; and 93 nonasthmatic patients, whose functional endoscopic sinus surgery was contemporaneous, were used as a control group for the surgical results. Asthma was a critical factor negatively affecting the outcome of sinus surgery. On the other hand, sinus disease extension did not correlate with asthma severity at any stage. Sinus surgery, despite being capable of improving asthma, ultimately failed to produce significant change in lung function scores. Furthermore, consistent good surgical results on the nose did not come across as a critical issue for postoperative asthma improvement. We concluded that, if the surgical intervention on the sinuses was found to be able clinically to benefit asthma evolution, other evidence does not seem to support a causative relationship between sinusitis and asthma. Instead, since asthma was shown to affect sinus disease severity significantly, their association apparently reflects a systemic inflammatory process of the respiratory mucosa.
authors.affiliation: Department of Otorhinolaryngology, Hospital de Pulido Valente, Lisbon, Portugal.
authors.forename: P B
authors.initials: PB
authors.lastname: Dinis
authors.forename: A
authors.initials: A
authors.lastname: Gomes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000150:complications* / Q000503:physiopathology; D016009:Chi-Square Distribution; D002648:Child; D004342:Drug Hypersensitivity / Q000175:diagnosis; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000601:surgery; D011127:Polyps / Q000601:surgery; D011182:Postoperative Care; D012720:Severity of Illness Index; D012852:Sinusitis / Q000145:classification / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin