Up-regulation of dopamine D1-receptors in the brain of 28-day-old rats exposed to the delta (delta) opioid agonist SNC80 during the preweaning period.
Twenty-eight-day-old rats exposed to the delta (delta) opioid receptor agonist SNC80 during the preweaning period exhibited a significant increase in the density and apparent dissociation constant of striatal dopamine D1-receptors. There were no significant effects on the binding characteristics of striatal D2-receptors or on D1- or D2-receptors in the nucleus accumbens. The results suggest that delta-opioid receptor mechanisms might be involved in certain neurological changes observed in offspring of mother addicted to opioids during nursing.
Shieh
G J
GJ
Department of Pharmacal Sciences, Auburn University School of Pharmacy, AL 36849-5503, USA.
Ravis
W R
WR
Walters
D E
DE
D000818:Animals; D000833:Animals, Suckling; D001549:Benzamides / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D005260:Female; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis* / Q000378:metabolism; D017465:Receptors, Opioid, delta / Q000819:agonists*; D015854:Up-Regulation
D001549:Benzamides; D010879:Piperazines; D017448:Receptors, Dopamine D2; D017465:Receptors, Opioid, delta; C088464:4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide