title: Association between strong inflammatory response and low risk of developing visual loss and other cranial ischemic complications in giant cell (temporal) arteritis.
abstract: OBJECTIVE
  To identify clinical and biochemical parameters that have good predictive value for identifying giant cell (temporal) arteritis (GCA) patients who are at high or low risk of developing cranial ischemic events.
  
  
  METHODS
  In this multicenter study, records of patients at 3 university hospitals in Barcelona were reviewed retrospectively. Two hundred consecutive patients with biopsy-proven GCA were studied.
  
  
  RESULTS
  Thirty-two patients developed irreversible cranial ischemic complications. The duration of clinical symptoms before diagnosis was similar in patients with and those without ischemic events. Patients with ischemic complications less frequently had fever (18.8% versus 56.9%) and weight loss (21.9% versus 62%) and more frequently had amaurosis fugax (32.3% versus 6%) and transient diplopia (15.6% versus 3.6%). Patients with ischemic events had lower erythrocyte sedimentation rates (ESR) (82.7 mm/hour versus 104.4 mm/hour) and higher concentrations of hemoglobin (12.2 gm/dl versus 10.9 gm/dl) and albumin (37.4 gm/liter versus 32.7 gm/liter). Clinical inflammatory status and biologic inflammatory status were defined empirically (clinical: fever and weight loss; biologic: ESR > or =85 mm/hour and hemoglobin < 11.0 gm/dl). Patients not showing a clinical and biologic inflammatory response were at high risk of developing ischemic events (odds ratio [OR] 5, 95% confidence interval [95% CI] 2.05-12.2). The risk was greatly reduced among patients with either a clinical (OR 0.177, 95% CI 0.052-0.605) or a biologic (OR 0.226, 95% CI 0.076-0.675) inflammatory reaction. No patient with both a clinical and a biologic response developed ischemic events.
  
  
  CONCLUSIONS
  The presence of a strong acute-phase response defines a subgroup of patients at very low risk of developing cranial ischemic complications. Our findings provide a rationale for testing less aggressive treatment schedules in these individuals. Conversely, a low inflammatory response and the presence of transient cranial ischemic events provide a high risk of developing irreversible ischemic complications and require a prompt therapeutic intervention.
authors.affiliation: Hospital Clínic, Barcelona, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Cid
authors.forename: C
authors.initials: C
authors.lastname: Font
authors.forename: J
authors.initials: J
authors.lastname: Oristrell
authors.forename: A
authors.initials: A
authors.lastname: de la Sierra
authors.forename: B
authors.initials: B
authors.lastname: Coll-Vinent
authors.forename: A
authors.initials: A
authors.lastname: López-Soto
authors.forename: J
authors.initials: J
authors.lastname: Vilaseca
authors.forename: A
authors.initials: A
authors.lastname: Urbano-Márquez
authors.forename: J M
authors.initials: JM
authors.lastname: Grau
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D015354:Vision, Low / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*