Effects of various resin composite (co)monomers and extracts on two caries-associated micro-organisms in vitro.
Previous studies have shown that extracts of various filling materials, e.g., resin composites, may influence the growth of cariogenic micro-organisms. The purpose of this study was to examine the effects of important resin composite (co)monomers (Bis-GMA, UDMA, TEGDMA, EGDMA) and extracts of two commercial dental composites with similar composition (composite A, Arabesk; composite S, Superlux) on the growth of the two cariogenic bacterial pathogens Streptococcus sobrinus and Lactobacillus acidophilus. It was found that neither the monomers Bis-GMA and UDMA, nor the comonomer EGDMA, nor the extract of composite A influenced the growth of S. sobrinus in the log phase. The comonomer TEGDMA and the extract of composite S were found to stimulate growth in the log phase, but this stimulation was not statistically significant. However, EGDMA, TEGDMA, and the extract of composite S did stimulate the total growth of S. sobrinus. In the assays with L. acidophilus, Bis-GMA, UDMA, and the extract of composite A inhibited the growth in the log phase, whereas TEGDMA stimulated it. Furthermore, EGDMA, TEGDMA, and the extract of composite S stimulated the biomass production of L. acidophilus. We conclude from our results that a release of EGDMA and TEGDMA from resin composites should be avoided due to their growth-stimulating effects on the caries-associated micro-organisms S. sobrinus and L. acidophilus.
Hansel
C
C
Department of Conservative Dentistry and Periodontology, Medical University Hannover, Germany.
Leyhausen
G
G
Mai
U E
UE
Geurtsen
W
W
D018533:Biomass; D017438:Bisphenol A-Glycidyl Methacrylate / Q000494:pharmacology; D015169:Colony Count, Microbial; D003188:Composite Resins / Q000494:pharmacology*; D003432:Cross-Linking Reagents / Q000494:pharmacology; D003731:Dental Caries / Q000382:microbiology*; D003764:Dental Materials / Q000494:pharmacology; D006801:Humans; D007779:Lactobacillus acidophilus / Q000187:drug effects* / Q000254:growth & development; D008689:Methacrylates / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology; D011109:Polymethacrylic Acids / Q000494:pharmacology; D011140:Polyurethanes / Q000494:pharmacology; D015203:Reproducibility of Results; D019279:Resin Cements / Q000494:pharmacology; D017640:Silicates / Q000494:pharmacology; D016986:Streptococcus sobrinus / Q000187:drug effects* / Q000254:growth & development
D003188:Composite Resins; D003432:Cross-Linking Reagents; D003764:Dental Materials; D008689:Methacrylates; D011109:Polymethacrylic Acids; D011140:Polyurethanes; D019279:Resin Cements; D017640:Silicates; C097957:Superlux Universal Hybrid; C029824:urethane dimethacrylate luting resin; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate; C004919:ethylene dimethacrylate