title: Prior segregation analysis and the power to detect linkage.
abstract: Complex parametric segregation and linkage analysis was performed on the simulated quantitative trait Q1 for all 200 replicates of the nuclear families data set. The segregation analysis inferred a major gene in 46% of the replicates. Among all replicates, including those that rejected a major gene, the power to detect suggestive linkage to any of three loci affecting Q1 was 0.600 and the false positive rate was 0.002. Among the replicates where a major gene was found, the power to detect suggestive linkage was 0.652 and the false positive rate was also 0.002. Thus, for purposes of linkage to this complex trait, a prior segregation then linkage analysis approach located a gene in 30% of all replicates, whereas a linkage only approach located a gene in 60% of all replicates.
authors.affiliation: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Atwood
authors.forename: S H
authors.initials: SH
authors.lastname: Slifer
mesh_terms: D003198:Computer Simulation; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D008540:Meiosis / Q000235:genetics*; D008957:Models, Genetic; D009679:Nuclear Family; D011237:Predictive Value of Tests; D019655:Quantitative Trait, Heritable