title: Successful treatment of herpes simplex virus (HSV) recurrent genital infection with recombinant human (rh) granulocyte-macrophage colony stimulating factor (GM-CSF): a case report.
abstract: In the present work, we describe the treatment with rhGM-CSF of a woman affected by HSV recurrent genital infection and not responsive to specific antiviral therapy. The therapeutic regimen consisted of a subcutaneous administration of 300 mg/day of rhGM-CSF for six days. Before treatment with rhGM-CSF, polymorphonuclear cell and monocyte functional capacities and the antibacterial activity exerted by T cells were profoundly depressed. After treatment, a normalization of immune functions and a progressive disappearance of clinical manifestations were observed.
authors.affiliation: Cattedra di Immunologia and Clinica Ostetrica e Ginecologica II, Facoltà di Medicina e Chirurgia, Università degli Studi di Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Altamura
authors.forename: M G
authors.initials: MG
authors.lastname: Geronimo
authors.forename: L
authors.initials: L
authors.lastname: Nappi
authors.forename: O
authors.initials: O
authors.lastname: Ceci
authors.forename: P
authors.initials: P
authors.lastname: Loizzi
authors.forename: E
authors.initials: E
authors.lastname: Jirillo
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D001770:Blood Bactericidal Activity; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010586:Phagocytes / Q000187:drug effects / Q000276:immunology; D011994:Recombinant Proteins / Q000627:therapeutic use; D018139:Simplexvirus; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000998:Antiviral Agents; D011994:Recombinant Proteins; D009240:N-Formylmethionine Leucyl-Phenylalanine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor