title: Electromotive drug administration of lidocaine and dexamethasone followed by cystodistension in women with interstitial cystitis.
abstract: Electromotive drug administration (EMDA) involves the active transport of ionized drugs such as lidocaine by the application of an electric current. Twenty-one female subjects with interstitial cystitis were treated with EMDA of lidocaine and dexamethasone, followed by cystodistension. The procedure was convenient and well tolerated, with hospital attendance for 1 hour. Bladder anesthesia was excellent, with cystodistension from a discomfort level of 200 ml to a mean volume of 600 ml. Eighty-five percent had a good response (reduction in frequency and in pain score by 3 or more) at 2 weeks, with 63% still responding at 2 months. An excellent response (pain score of 0) was present in 25% of patients reviewed at 6 months. These results are comparable to the response following cystodistension under general anesthesia. There is a need for a randomized blinded comparison of lidocaine with and without EMDA. If proven to be of pharmacological efficacy, EMDA would have many applications in facilitating procedures previously requiring general anesthesia.
authors.affiliation: Royal Women's Hospital, Carlton Victoria, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Rosamilia
authors.forename: P L
authors.initials: PL
authors.lastname: Dwyer
authors.forename: J
authors.initials: J
authors.lastname: Gibson
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018856:Cystitis, Interstitial / Q000188:drug therapy / Q000628:therapy*; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007478:Iontophoresis; D008012:Lidocaine / Q000008:administration & dosage*; D008875:Middle Aged
chemical_list: D003907:Dexamethasone; D008012:Lidocaine