Cell proliferation, cell death and angiogenesis in early and advanced gastric cancer of intestinal type.
Mitotic (MI) and apoptotic index (AI), the sum of the 2, i.e., the turnover index (TI), tumor neovascularization (NV) and p53 expression, as well as tumor grading and node status, are evaluated in early and advanced gastric-cancer cases. T1 cases show significantly less frequent lymph-node invasion and lower tumor grade, and, taken together, have significantly lower MI, Al and TI and higher values of NV than the T2-3 cases. However, correlation of the variables shows that the above-mentioned discrimination is due to a minority of T1 cases (11 out of 33), while the majority of them are allocated in the same 95% ellipse of tolerance of the T2-3 cases.
Vindigni
C
C
Institute of Pathological Anatomy and Histology, University of Siena, Italy.
Miracco
C
C
Spina
D
D
Presenti
L
L
Gallorini
M
M
Vatti
R
R
de Stefano
A
A
Roviello
F
F
Pinto
E
E
Filipe
M I
MI
Tosi
P
P
D001399:Azure Stains; D002453:Cell Cycle / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007422:Intestines / Q000473:pathology; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D015203:Reproducibility of Results; D013194:Staining and Labeling / Q000379:methods; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D001399:Azure Stains; D004273:DNA, Neoplasm; D016159:Tumor Suppressor Protein p53; C025818:Azure A