A mammalian homolog of the bacterial monomeric sarcosine oxidases maps to mouse chromosome 11, close to Cryba1.
We have cloned a cDNA from a mouse gene, Pso (peroxisomal sarcosine oxidase). Pso appears to encode a homolog of the single-subunit (40 kDa) bacterial sarcosine oxidases. The mouse Pso gene product would contain a peroxisomal localization sequence, like that of the recently reported rabbit enzyme, Mouse Pso lies between 20 and 50 kb upstream of the promoter of the Sez6 gene, close to Crybal on chromosome 11. Pso is expressed very strongly and specifically in liver and kidney. The gene appears to be present widely in eutherian mammals.
Herbst
R
R
Department of Medicine and Pharmacology, University of Sheffield, Royal Hallamshire Hospital, United Kingdom.
Barton
J L
JL
Nicklin
M J
MJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003459:Crystallins / Q000235:genetics*; D018076:DNA, Complementary; D008322:Mammals; D051379:Mice; D008969:Molecular Sequence Data; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics*; D011817:Rabbits; D050879:Sarcosine Oxidase; D017386:Sequence Homology, Amino Acid; D038205:beta-Crystallin A Chain
C051374:Cryba1 protein, mouse; D003459:Crystallins; D018076:DNA, Complementary; D038205:beta-Crystallin A Chain; D010089:Oxidoreductases, N-Demethylating; C494350:Pipox protein, mouse; D050879:Sarcosine Oxidase