title: Antiplasmodial triterpene from Vernonia brasiliana.
abstract: The hexane extract from leaves of Vernonia brasiliana (L.) Druce (Compositae) was active in vitro against Plasmodium falciparum and in vivo in mice infected with Plasmodium berghei. This extract was subjected to a bioassay-guided fractionation protocol based on the in vitro model. Lupeol was identified as a compound responsible for the activity, inhibiting the P.falciparum growth by 45% when tested at 25 micrograms/ml. However, this triterpene was inactive in vivo when 15 mg/kg were administered per os during four consecutive days to mice infected with P.berghei. beta-Amyrin and germanicol, isolated from the same fraction that yielded lupeol, were inactive in the in vitro assay.
authors.affiliation: Lab. de Química de Produtos Naturais, FIOCRUZ, Belo Horizonte, MG, Brazil.
authors.forename: T M
authors.initials: TM
authors.lastname: Alves
authors.forename: T J
authors.initials: TJ
authors.lastname: Nagem
authors.forename: L H
authors.initials: LH
authors.lastname: de Carvalho
authors.forename: A U
authors.initials: AU
authors.lastname: Krettli
authors.forename: C L
authors.initials: CL
authors.lastname: Zani
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D051379:Mice; D010944:Plants / Q000737:chemistry*; D010962:Plasmodium berghei / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D014315:Triterpenes