title: Herpes simplex virus type-2, cytomegalovirus and Epstein-Barr virus infection in acute non A to E hepatitis Thai patients.
abstract: A significant number of acute non A to E hepatitis cases are reported in Thailand every year, and the etiologies of these cases are unknown. Members of the herpesviridae family have been reported to cause either a self limited or fatal hepatitis in a small proportion of patients in other parts of the world. To determine whether herpesviruses may play a role in acute non A to E hepatitis, sera from 32 acute hepatitis patients without markers for acute hepatitis A to E virus infection were examined for IgM to herpesvirus type 2 (HSV-2), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) using commercially available assays. IgM to HSV-2 was detected in four sera, IgM to CMV was detected in one serum, and IgM to EBV was detected in one serum. All of the acute non A to E hepatitis patients recovered and none had underlying conditions associated with impaired immunity. These results suggest that herpesviruses should be considered in the differential diagnosis for Thai patients with hepatitis.
authors.affiliation: Faculty of Tropical Medicine, Siriraj Hospital, Bangkok, Thailand.
authors.forename: Y
authors.initials: Y
authors.lastname: Maneerat
authors.forename: P
authors.initials: P
authors.lastname: Wilairatana
authors.forename: E
authors.initials: E
authors.lastname: Pongponratn
authors.forename: P
authors.initials: P
authors.lastname: Puthavathana
authors.forename: U
authors.initials: U
authors.lastname: Chaisri
authors.forename: S
authors.initials: S
authors.lastname: Kurathong
authors.forename: A
authors.initials: A
authors.lastname: Juthaputhi
authors.forename: E T
authors.initials: ET
authors.lastname: Clayson
authors.forename: R
authors.initials: R
authors.lastname: Snitbhan
authors.forename: B
authors.initials: B
authors.lastname: Raengsakulrach
authors.forename: D W
authors.initials: DW
authors.lastname: Vaughn
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D006558:Herpes Genitalis / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D018258:Herpesvirus 2, Human / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D013785:Thailand