title: Fibromyomas and uterine contractions.
abstract: BACKGROUND
  Women with uterine fibromyomas may suffer from dysmenorrhea, menorrhagia or infertility, which all may be due to an effect of the fibroids on uterine activity. The effect of myomectomy on uterine contractility is unknown.
  
  
  METHODS
  In women undergoing myomectomy because of dysmenorrhea, menorrhagia or infertility, intrauterine pressure was recorded before and three months after the operation on corresponding days of the menstrual cycle. Records were obtained during spontaneous uterine activity as well as after oxytocin and vasopressin challenge by intravenous bolus injections of 10 pmol/kg body weight. The area under the recording curve (AUC), maximal amplitude of uterine contractions and deformation index of uterine pressure recordings were measured.
  
  
  RESULTS
  In six women, in whom recordings could be obtained before and after operation on corresponding days of late follicular phase of the menstrual cycle, the AUC and maximal amplitude of contractions increased after myomectomy. The effect of oxytocin injection also varied, whereas no difference was seen in effect of vasopressin.
  
  
  CONCLUSIONS
  It is suggested that women with uterine fibromyomas may have disturbed uterine spontaneous contractions and responsiveness, which may be regulated by myomectomy.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospitals of Bialystok, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Szamatowicz
authors.forename: T
authors.initials: T
authors.lastname: Laudanski
authors.forename: B
authors.initials: B
authors.lastname: Bulkszas
authors.forename: M
authors.initials: M
authors.lastname: Akerlund
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D007247:Infertility, Female / Q000209:etiology* / Q000601:surgery; D007889:Leiomyoma / Q000503:physiopathology* / Q000601:surgery; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects / Q000502:physiology*; D014594:Uterine Neoplasms / Q000503:physiopathology* / Q000601:surgery; D014599:Uterus / Q000187:drug effects; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D014667:Vasopressins; D010121:Oxytocin