title: [The influence of ricin on the course of experimental infections of mice with Trichinella spiralis].
abstract: Mice received 5 ng of ricin 24 hours after infection (experiment I) or 1 ng of ricin twice, 24 hours and 17 days of infection (experiment II). Animals were killed in 7, 14, 21, 28, 35, 42 and 60 days after infection. In the jejunum and masseter muscle sections, CD4+ and CD8+ lymphocytes, mast cells and eosinophils were studied. Heavy suppression of CD8+ lymphocytes, strong eosinophils and less pronounced mast cells stimulation was observed in the jejunum of mice received ricin (experiment I). Worm expulsion in intestine was faster than in the control (opposite results in experiment II). The composition of cells infiltration in the muscle was in both experiments similar to the control, however, fewer CD4+ lymphocytes were observed in larva capsule and there were fewer muscle larvae. Therefore CD8+ cells are believed to take part in restricting only the muscle stage of trichinellosis.
authors.affiliation: Instytut Parazytologii PAN im. W. Stefańskiego, Wrocław.
authors.forename: K
authors.initials: K
authors.lastname: Karmańska
authors.forename: M
authors.initials: M
authors.lastname: Houszka
authors.forename: A
authors.initials: A
authors.lastname: Widyma
authors.forename: E
authors.initials: E
authors.lastname: Stefaniak
mesh_terms: D000818:Animals; D016516:CD4-CD8 Ratio / Q000187:drug effects; D004334:Drug Administration Schedule; D004804:Eosinophils / Q000187:drug effects; D006790:Host-Parasite Interactions / Q000187:drug effects; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy* / Q000276:immunology; D007583:Jejunum / Q000276:immunology / Q000469:parasitology; D007814:Larva / Q000187:drug effects; D008297:Male; D008406:Masseter Muscle / Q000276:immunology / Q000469:parasitology; D008407:Mast Cells / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D012276:Ricin / Q000627:therapeutic use*; D017160:Trichinella spiralis / Q000187:drug effects* / Q000502:physiology; D014235:Trichinellosis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D012276:Ricin