Effects of vitamin E and cimetidine on peritonitis-induced lipid peroxidation.
To investigate the effects of acute fecal peritonitis on plasma and tissue lipid peroxidation and possible protective effects of vitamin E (Vit E) and cimetidine at 4 h in a rat peritonitis model, four groups were designated as: controls, peritonitis, Vit E and cimetidine. Plasma, liver, lung and kidney thiobarbituric acid reactive substances (TBARS) and conjugated diene (CD) levels were measured to monitor oxidative injury. The present fecal peritonitis model caused a significant elevation in liver TBARS; however, neither Vit E nor cimetidine was effective in preventing TBARS formation. Administration of Vit E and cimetidine caused significant decrements from the peritonitis value in liver and lung CD levels.
Tuncel
P
P
Uludağ University Faculty of Medicine, Department of Biochemistry, Bursa, Turkey.
Gür
E S
ES
Kaya
E
E
Ozbek
R
R
Oztürk
E
E
Tokyay
R
R
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D010538:Peritonitis / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*
D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D002927:Cimetidine