title: Influence of digital rectal massage on urinary prostate-specific antigen: interest for the detection of local recurrence after radical prostatectomy.
abstract: BACKGROUND
  Following radical prostatectomy, urinary prostate-specific antigen (uPSA) may originate from periurethral glands or from recurrent carcinomatous prostatic cells. We evaluated massage of the urethro-vesical anastomosis as a uPSA-releasing method for the detection of local recurrence.
  
  
  METHODS
  PSA was assessed (PSA IMx, Abbott Diagnostic, Rungis, France) in serum and in the first voided urine before and after massage in 59 patients: 7 after cystoprostatectomy for bladder cancer, 22 with prostate in situ, and 30 after radical prostatectomy for prostate cancer.
  
  
  RESULTS
  No significant changes of uPSA were induced by the massage in cystoprostatectomy patients and in 4 radical prostatectomy patients with a negative biopsy of the anastomosis. In contrast, a significant increase of uPSA was observed after massage in the patients with prostate in situ and in 6 radical prostatectomy patients with biopsy-proven local relapse.
  
  
  CONCLUSIONS
  uPSA before and after massage of the prostatic fossa may constitute a new and efficient tool for the detection of local recurrence, if these preliminary results are confirmed on a larger scale.
authors.affiliation: Department of Urology, Toulouse-Purpan University Hospital, France.
authors.forename: B
authors.initials: B
authors.lastname: Malavaud
authors.forename: G
authors.initials: G
authors.lastname: Salama
authors.forename: M
authors.initials: M
authors.lastname: Miédougé
authors.forename: C
authors.initials: C
authors.lastname: Vincent
authors.forename: P
authors.initials: P
authors.lastname: Rischmann
authors.forename: J P
authors.initials: JP
authors.lastname: Sarramon
authors.forename: G
authors.initials: G
authors.lastname: Serre
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D006801:Humans; D008297:Male; D008405:Massage / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D011467:Prostate / Q000378:metabolism / Q000601:surgery; D017430:Prostate-Specific Antigen / Q000097:blood / Q000652:urine*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D012007:Rectum
chemical_list: D017430:Prostate-Specific Antigen