title: Are antibiotics necessary in the surgical management of upper limb lacerations?
abstract: Previous research has shown that antibiotic usage in patients with superficial sharp lacerations has no influence over infection rate. This study is a prospective controlled trial, using systematic allocation, of 250 patients of which 113 received co-amoxiclav (Augmentin) and 137 did not. Special emphasis was placed on wound debridement and irrigation. All sharp soft tissue lacerations including those with nerve, tendon and muscle damage were entered into the trial. The results show a low overall infection rate of 4%. The infection rate in the group treated with antibiotics was 5% and 3.2% in the group who received no antibiotics. Lacerations operated on up to 48 h from the injury were included and there was no correlation between the length of time waited and the infection rate. We conclude that antibiotics are an unnecessary adjunct in the treatment of sharp lacerations of the hand and upper limb, provided meticulous surgical debridement is performed.
authors.affiliation: Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea, South Wales, UK.
authors.forename: O C
authors.initials: OC
authors.lastname: Cassell
authors.forename: L
authors.initials: L
authors.lastname: Ion
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D002648:Child; D002675:Child, Preschool; D003646:Debridement; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005543:Forearm Injuries / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D007507:Therapeutic Irrigation; D014946:Wound Infection / Q000517:prevention & control*; D014950:Wounds, Penetrating / Q000601:surgery*
chemical_list: D019980:Amoxicillin-Potassium Clavulanate Combination