[Biotechnological approaches to the development of therapeutic and diagnostic preparations of lipid nature].
The paper summarizes own results of studies on phospholipids and glycolipids from natural biological sources. New approaches for synthesis of inositol-containing sphingophospholipids, glycophosphatidylinositols, semisynthetic synthesis of phosphoglycerols have been introduced. New industrial method of phosphjatidylcholine isolation and production of number of lipid preparations were developed. Incorporation of DOPA into liposomes increases efficacy of its action in the medication of MPTP-induced parkinsonism in mice.
Shvetz
V I
VI
Krasnopol'skiĭ
Iu M
IuM
Kaplun
A P
AP
Stepanov
A E
AE
D000818:Animals; D001688:Biological Products / Q000302:isolation & purification / Q000627:therapeutic use; D001709:Biotechnology / Q000379:methods*; D064907:Diagnostic Uses of Chemicals; D004337:Drug Carriers; D004358:Drug Therapy; D006801:Humans; D008055:Lipids / Q000138:chemical synthesis* / Q000302:isolation & purification*; D008081:Liposomes; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000302:isolation & purification*
D001688:Biological Products; D064907:Diagnostic Uses of Chemicals; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D004364:Pharmaceutical Preparations