title: Allele distribution of D5S125, MAP1B5' and D5S679 microsatellite markers in Turkish spinal muscular atrophy families.
abstract: Spinal muscular atrophy (SMA) is an autosomal recessive disease and one of the most common genetic causes of death in childhood. The gene for SMA has been mapped to chromosome 5q11.2-13.3. Chromosomal distribution of the alleles of D5S125, MAP1B5' and D5S679 polymorphic microsatellite markers in 14 unrelated Turkish SMA families have been determined. It is observed that the A9 allele of D5S679 has a significant (chi 2: 3.41 p: 0.065) non-random association with mutant chromosomes.
authors.affiliation: Department of Medical Biology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Erdem
authors.forename: S
authors.initials: S
authors.lastname: Pehlivan
authors.forename: H
authors.initials: H
authors.lastname: Topaloğlu
authors.forename: I
authors.initials: I
authors.lastname: Togan
authors.forename: M
authors.initials: M
authors.lastname: Ozgüç
mesh_terms: D000483:Alleles; D016009:Chi-Square Distribution; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D003241:Consanguinity; D004276:DNA, Satellite / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008297:Male; D009134:Muscular Atrophy, Spinal / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers