Chromatin assembly factors: a dual function in nucleosome formation and mobilization?
Chromatin assembly is a process that interfaces DNA replication, gene expression and progression through the cell cycle, and it is therefore critically involved in many important biological phenomena. This brief review provides a general background to the study of chromatin assembly, as well as an overview of putative chromatin assembly factors. Interestingly, recent data suggest that the ATP-utilizing chromatin assembly factor, ACF, functions not only in nucleosome formation, but also in the ATP-dependent remodelling of chromatin that facilitates DNA-utilizing processes, such as transcription, replication, recombination, and repair.
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Department of Biology, Centre for Molecular Genetics, University of California, San Diego, La Jolla, 92093-0347, USA.
Tyler
J K
JK
Kadonaga
J T
JT
D000255:Adenosine Triphosphate / Q000378:metabolism; D018797:Cell Cycle Proteins; D002843:Chromatin / Q000378:metabolism*; D056504:Chromatin Assembly Factor-1; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D009687:Nuclear Proteins; D056490:Nucleosome Assembly Protein 1; D009707:Nucleosomes / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D018797:Cell Cycle Proteins; D002843:Chromatin; D056504:Chromatin Assembly Factor-1; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D006657:Histones; D009687:Nuclear Proteins; D056490:Nucleosome Assembly Protein 1; D009707:Nucleosomes; D011506:Proteins; D014157:Transcription Factors; D000255:Adenosine Triphosphate