title: Detection of measles virus mRNA from autopsied human tissues.
abstract: By reverse transcription-PCR, measles virus (MV) mRNA was detected in the brain, kidney, spleen, liver, and lung tissues obtained from 23 (45.1%) of 51 autopsy subjects, with the detection rates of each tissue ranging from 8 to 20%. Sequence analysis revealed frequent mutations in the corresponding viral protein. These results suggest that MV mutants commonly persist in apparently healthy individuals.
authors.affiliation: Department of Microbiology, Kobe University School of Medicine, Hyogo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Kohso
authors.forename: A
authors.initials: A
authors.lastname: Nishimura
authors.forename: Y
authors.initials: Y
authors.lastname: Tatsuno
authors.forename: M
authors.initials: M
authors.lastname: Homma
authors.forename: H
authors.initials: H
authors.lastname: Hotta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D001344:Autopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008459:Measles virus / Q000235:genetics*; D008875:Middle Aged; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis*; D012367:RNA, Viral / Q000032:analysis*
chemical_list: D012333:RNA, Messenger; D012367:RNA, Viral