Modulatory role of lipoprotein oxidation on platelet-vessel wall interactions.
Oxidation of plasma lipoproteins may play an important role in atherogenesis, but there are also indications that that this process of oxidation may influence other facets of cardiovascular disease, namely blood flow and thrombosis. The evidence that oxidation of low-density lipoproteins may modulate the action of the native lipoproteins with respect to endothelium-dependent relaxation, platelet activation and tissue factor activity is reviewed.
Bruckdorfer
K R
KR
Department of Biochemistry and Molecular Biology, Royal Free Hospital School of Medicine, University of London, UK.
D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology*; D001808:Blood Vessels / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008074:Lipoproteins / Q000737:chemistry / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D015539:Platelet Activation / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D008074:Lipoproteins; D008077:Lipoproteins, LDL