[The Wermer syndrome].
The difficult diagnostic and therapeutic management of patients having gastrinoma with multiple endocrine neoplasia type I (MEN I) has been discussed by reference to the literature and a personal experience of 2 patients with Wermer syndrome. The syndrome is often familial and might be inherited as an autosomal dominant trait with a high but variable degree of penetrance. Pancreatic islets, parathyroid glands and adenohypophyseal [correction of antehypophyseal] cells are the three localization main for endocrine involvement in MEN I syndrome.
Târcoveanu
E
E
Clinica I Chirurgie, Spitalul Universitar Sf. Spiridon, Iaşi.
Strat
V
V
Cotea
E
E
Filip
V
V
Zbranca
E
E
Vulpoi
C
C
Florea
N
N
Daniil
C
C
Crumpei
F
F
Rusu
V
V
D000328:Adult; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D015408:Gastrinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010282:Parathyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010437:Peptic Ulcer / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D012086:Reoperation