Antioxidants and AP-1 activation: a brief overview.
Activity of the transcription factor AP-1 is controlled by different MAPK cascades that regulate the different AP-1 components at the transcriptional and posttranscriptional level. Recently, AP-1 has been shown to behave as a redox-sensitive transcription factor that can be induced under both pro-oxidative and antioxidative conditions. In this overview we summarize the signaling pathways that converge on the activation of AP-1 and the components of these pathways that have been shown to be targets of antioxidants. The activation of AP-1 by antioxidants may account for the expression of a number of genes that mediate important functions under physiological conditions.
Gomez del Arco
P
P
Servicio de Inmunología, Hospital de la Princesa, Madrid, Spain.
Martínez-Martínez
S
S
Calvo
V
V
Armesilla
A L
AL
Redondo
J M
JM
D000975:Antioxidants / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D015398:Signal Transduction; D018808:Transcription Factor AP-1 / Q000378:metabolism*
D000975:Antioxidants; D018808:Transcription Factor AP-1