(-)-formoterol, a selective beta 2-adrenoreceptor agonist.
The crystal structure of (-)-formoterol [2-hydroxy- 5-(hydroxy-2-¿[2-(p-methoxyphenyl)-1-methylethyl]- amino¿ethyl)formanilide (+)-tartrate, C19H25N2O4+.C4H5O6-] has been determined in order to elucidate its configuration relative to that of (+)-tartrate. The result is consistent with the configuration proposed on the basis of the chemical correlation experiments.
Kurihara
H
H
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan. kurihara@yamanouchi.co.jp
Fujita
S
S
Mase
T
T
D000318:Adrenergic beta-Agonists / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D004983:Ethanolamines / Q000737:chemistry*; D000068759:Formoterol Fumarate; D006860:Hydrogen Bonding; D015394:Molecular Structure; D013237:Stereoisomerism
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D000068759:Formoterol Fumarate