title: Severe acute liver failure as the initial manifestation of haematological malignancy.
abstract: Acute liver failure is rarely secondary to lymphoma or leukaemia and it is extremely uncommon as the initial presentation of malignancy. We report a case of a young adult patient with severe acute liver failure referred for liver transplant, in which a Burkitt acute lymphoblastic leukaemia was diagnosed by bone marrow examination. A complete recovery and long remission were obtained with chemotherapy.
authors.affiliation: Department of Gastroenterology, Coimbra University Hospital, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Souto
authors.forename: J M
authors.initials: JM
authors.lastname: Romãozinho
authors.forename: P
authors.initials: P
authors.lastname: Figueiredo
authors.forename: M
authors.initials: M
authors.lastname: Ferreira
authors.forename: I
authors.initials: I
authors.lastname: Sousa
authors.forename: E
authors.initials: E
authors.lastname: Camacho
authors.forename: A
authors.initials: A
authors.lastname: Donato
authors.forename: D
authors.initials: D
authors.lastname: Freitas
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002051:Burkitt Lymphoma / Q000175:diagnosis* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006529:Hepatomegaly / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D017114:Liver Failure, Acute / Q000175:diagnosis* / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate