Association between the tryptophan hydroxylase gene and manic-depressive illness.
BACKGROUND
Genes encoding proteins involved in serotonergic metabolism are major candidates in association studies of mood disorders and suicidal behavior. This association study explores whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme of serotonin biosynthesis, is a susceptibility factor for manic-depressive illness, with or without a history of suicide attempts.


METHODS
The TPH intron 7 A218C polymorphism was determined using a polymerase chain reaction-based method in DNA samples from 152 patients with bipolar disorder and 94 healthy control subjects.


RESULTS
There was a significant association between TPH genotypes and manic-depressive illness. Among patients with bipolar disorder, no association was found between TPH alleles and suicidal behavior.


CONCLUSIONS
This result suggests the involvement of the TPH gene in susceptibility to manic-depressive illness. This preliminary result requires confirmation in further groups of patients and controls.
Bellivier
F
F
Laboratoire de Recherche sur les Personnalités et les Conduites Adaptatives, Hôpital Pitié-Salpétrière, Paris, France. fbell@ext.jussieu.fr
Leboyer
M
M
Courtet
P
P
Buresi
C
C
Beaufils
B
B
Samolyk
D
D
Allilaire
J F
JF
Feingold
J
J
Mallet
J
J
Malafosse
A
A
D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics* / Q000523:psychology; D004198:Disease Susceptibility / Q000201:enzymology; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012701:Serotonin / Q000096:biosynthesis; D013405:Suicide / Q000523:psychology; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data; D014365:Tryptophan Hydroxylase / Q000235:genetics* / Q000502:physiology; D014754:Violence / Q000523:psychology
D005819:Genetic Markers; D012701:Serotonin; D014365:Tryptophan Hydroxylase