Eicosanoids: role in gastrointestinal inflammation and cancer.
This paper contains a brief review of the metabolism and physiological actions of eicosanoids, with a discussion of the potential clinical implications of disturbances in eicosanoid metabolism, particularly in NSAID-induced upper gastrointestinal damage and inflammatory bowel disease. There follows a summary of current evidence for the role of eicosanoids in the pathogenesis of colorectal neoplasia.
Davies
G R
GR
Centre for Digestive Diseases, The General Infirmary, Leeds, UK.
Rampton
D S
DS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000517:prevention & control; D003111:Colonic Polyps / Q000517:prevention & control; D015179:Colorectal Neoplasms / Q000503:physiopathology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D015777:Eicosanoids / Q000378:metabolism / Q000502:physiology*; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D011448:Prostaglandin Antagonists / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D015777:Eicosanoids; D011448:Prostaglandin Antagonists