title: Primary hyperparathyroidism with osteodystrophia fibrosa of the facial bones in a pony.
abstract: A 17-year-old pony mare was admitted for evaluation of progressive enlargement of the facial bones during the preceding 9 months. Laboratory testing revealed that the pony had hypercalcemia, hypophosphatemia, high urinary fractional excretion of phosphorus, and high serum concentration of intact parathyroid hormone (185.1 pmol/L; reference range, 0.25 to 2.0 pmol/L). On the basis of these findings, a diagnosis of primary hyperparathyroidism was made by ruling out nutritional secondary hyperparathyroidism, chronic renal disease, and pseudohyperparathyroidism resulting from neoplasia. Although primary hyperparathyroidism is best treated by surgical removal of the affected parathyroid gland, the owners declined surgical exploration of the neck in this pony. Because of the poor prognosis, the pony was euthanatized. A functional lesion of the parathyroid tissue was not located on necropsy or histologic examination. Difficulty localizing and grossly identifying parathyroid tissue in horses complicates definitive diagnosis and treatment of primary hyperparathyroidism.
authors.affiliation: Department of Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-1240, USA.
authors.forename: N
authors.initials: N
authors.lastname: Frank
authors.forename: J F
authors.initials: JF
authors.lastname: Hawkins
authors.forename: L L
authors.initials: LL
authors.lastname: Couëtil
authors.forename: J T
authors.initials: JT
authors.lastname: Raymond
mesh_terms: D000818:Animals; D005147:Facial Bones / Q000473:pathology; D005260:Female; D006734:Horse Diseases / Q000209:etiology*; D006736:Horses; D006961:Hyperparathyroidism / Q000150:complications / Q000662:veterinary*; D010002:Osteitis Fibrosa Cystica / Q000209:etiology / Q000662:veterinary*; D010281:Parathyroid Hormone / Q000097:blood
chemical_list: D010281:Parathyroid Hormone