Extensive immunoglobulin binding of Plasmodium falciparum-infected erythrocytes in a group of children with moderate anemia.
Immunoglobulins (Ig) from healthy, nonimmune individuals bind to the surfaces of Plasmodium falciparum-infected erythrocytes (RBC). In order to investigate the presence of this parasite phenotype in wild isolates and its potential association with malarial anemia, we conducted a study of 207 anemic or nonanemic children with malaria in Gabon. Surface Ig binding to infected RBC was detected for 83% of the isolates. No difference in Ig binding between the groups was observed, but all isolates which exhibited extensive Ig binding were found in a group of moderately anemic children.
Scholander
C
C
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden.
Carlson
J
J
Kremsner
P G
PG
Wahlgren
M
M
D000293:Adolescent; D000740:Anemia / Q000150:complications* / Q000453:epidemiology / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000276:immunology* / Q000469:parasitology*; D005681:Gabon / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis / Q000276:immunology*; D007223:Infant; D016778:Malaria, Falciparum / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D012397:Rosette Formation
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins