title: Studies on the hazardous effects and the maximum allowable concentration of pyrophyllite dust.
abstract: Pyrophyllite (H2Al2Si4O22) dust (P-dust) is a mixture of silica (10-40%), different proportions of a luminium oxide (Al2O3), and various metal compounds. People with occupations known to be associated with exposure to P-dust include miners, other industrial workers and persons engaged in artistic carving. Currently, little is known about pyrophyllite pneumoconiosis from P-dust. This study was designed to investigate the hazardous effects of P-dust and to suggest a maximum allowable concentration (MAC) of the dust. This study included four parts: (i) Occupational epidemiology survey in 781 workers from 1 pyrophyllite mine (PM) and four pyrophyllite carving mills (PCM), with a registration rate of 98%. (ii)
  
  
  METHODS
  Six groups of rats were exposed to different levels of P-dust; the cytotoxicity of P-dust on rat alveolar macrophages (AM) was investigated by determining the potassium content of AM and the activity levels of lactate dehydrogenase (LDH) in AM culture fluid, (iii) Mineralogical analysis of P-dust: The contents of silica (SiO2), aluminum (Al), ferrum (Fe), nickel (Ni), zinc (Zn) and copper (Cu) in both PM-dust and PCM-dust were determined. (iv) Determination of P-dust MAC: Using the life-talbe method, an investigation of the hygiene standard of P-dust was carried out in 625 workers exposed to either PM-dust or PCM-dust, upon whom routine radiographs were performed. The results suggest that the risk of developing pneumoconiosis from pyrophyllite dust is significantly higher for PM workers than for PCM workers. The prevalence rate of PCM-dust pneumoconiosis is significantly higher in men than in women. The content of SiO2 and Al2O3 in the mixture of P-dust is the most important factor in the etiology of pyrophyllitosis. Depending on the different P-dust MAC values, we suggest that 2 mg/m3 and 4 mg/m3 should be considered as the MAC for PM-dust and PCM-dust, respectively, and 3 mg/m3 for P-dust. We believe that establishing different hygiene standards is more accurate even though workers are exposed to the "same" dust.
authors.affiliation: Department of Occupational Health, Fujian Medical University, China.
authors.forename: W C
authors.initials: WC
authors.lastname: Zhang
authors.forename: Q F
authors.initials: QF
authors.lastname: Zhang
authors.forename: Z F
authors.initials: ZF
authors.lastname: Song
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis*; D000538:Aluminum Silicates / Q000009:adverse effects*; D000818:Animals; D002478:Cells, Cultured; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D016676:Macrophages, Alveolar / Q000378:metabolism; D008297:Male; D008452:Maximum Allowable Concentration; D008903:Minerals / Q000032:analysis*; D008906:Mining; D011009:Pneumoconiosis / Q000453:epidemiology / Q000209:etiology*; D011188:Potassium / Q000032:analysis; D015995:Prevalence; D051381:Rats; D012613:Sculpture
chemical_list: D000395:Air Pollutants, Occupational; D000538:Aluminum Silicates; D008903:Minerals; C049037:aluminosilicate; D007770:L-Lactate Dehydrogenase; D011188:Potassium