Coagulation inhibitors in alcoholic liver cirrhosis.
In the present study we have analyzed the relationship between coagulation inhibitors (antithrombin III, protein C and S, thrombomodulin), liver function impairment, and plasma activity of the endothelium-derived proteins plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) in 27 alcoholic cirrhotic patients and 25 controls. Cirrhotics showed decreased values of all the mentioned parameters except for thrombomodulin, PAI-1, and t-PA. Thrombomodulin and t-PA levels were higher in cirrhotics. No relationship was observed between thrombomodulin and t-PA or PAI-1. Protein C and antithrombin III levels were significantly lower in Child's C patients, whereas no correlation was found between t-PA and thrombomodulin and hepatic function derangement. PAI-1 activity was normal in our patients.
Raya-Sánchez
J M
JM
Dpto. de Medicina Interna, Hospital Universitario de Canarias, La Laguna, Tenerife, Canary Islands, Spain.
González-Reimers
E
E
Rodríguez-Martín
J M
JM
Santolaria-Fernández
F
F
Molina-Pérez
M
M
Rodríguez-Moreno
F
F
Martínez-Riera
A
A
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000378:metabolism; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000145:classification; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D018180:Thrombomodulin / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000378:metabolism
D019774:Blood Coagulation Factor Inhibitors; D017395:Plasminogen Activator Inhibitor 1; D011486:Protein C; D017293:Protein S; D018180:Thrombomodulin; D000990:Antithrombin III; D010959:Tissue Plasminogen Activator