title: [Body adaptation to the action of ecological factors at the cellular and subcellular levels].
abstract: Chemical and physical factors action on different organ tissues in animals were examined by light and electron microscopy. Comparison of the action of the agents mentioned showed, that in both cases the totality of compensatory-adaptive reactions depends on heterochronism of the changes that develop in organelles, cells and tissues and is determined by individual sensitivity of animals and asynchronism of the development of primary reactions at the organelle level, which accounts for mosaic pattern of structure of cells, comprising the tissues. It is established that in cells energy metabolism is disturbed first due to mitochondria damage irrespective of the unfavourable factor. The phenomenon of tissue adaptation is considered as an integrative process that occur within the ontogenesis. The entire process of tissue adaptation at the level of cells and organelles is divided on 5 stages according to structural changes demonstrated while exerting the influence. This allows to estimate both direction and significance of the damage and tissue compensatory and reparative capacity.
authors.forename: A A
authors.initials: AA
authors.lastname: Puzyrev
authors.forename: V F
authors.initials: VF
authors.lastname: Ivanova
authors.forename: V G
authors.initials: VG
authors.lastname: Maĭmulov
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002477:Cells / Q000187:drug effects* / Q000648:ultrastructure; D004463:Ecology; D004781:Environmental Exposure / Q000009:adverse effects*; D005579:Fossil Fuels / Q000009:adverse effects; D009622:Noise / Q000009:adverse effects; D009943:Organophosphorus Compounds / Q000009:adverse effects; D051381:Rats; D012038:Regeneration / Q000187:drug effects; D014508:Urea / Q000009:adverse effects; D014732:Vibration / Q000009:adverse effects
chemical_list: D005579:Fossil Fuels; D009943:Organophosphorus Compounds; D014508:Urea