title: One year follow-up study of endocrine and lung function of asthmatic children on inhaled budesonide.
abstract: Inhaled corticosteroids have become a mainstay in the management of chronic asthma. Their use had been considered safe, although some degree of adrenal suppression has been demonstrated after 2 and 4 weeks of treatment with either 400 microg x day(-1) of beclomethasone dipropionate or budesonide. To weigh the benefits and risks of long-term treatment, 12 children with moderately severe asthma were assessed in a follow-up study on budesonide 200 microg b.i.d. After 1 yr, the nocturnal cortisol production was significantly reduced by 19%, but no greater compared to 2 and 4 weeks of treatment. Growth and growth hormone levels were normal. Lung function tests were significantly better, not only versus baseline values but also versus 2 and 4 weeks of treatment. We conclude that systemic effects of inhaled corticosteroids in conventionally low doses do not accumulate with length of treatment, whilst lung function parameters will continue to improve. Therefore, inhaled corticosteroids once started in asthmatic children not controlled on other medications should be continued, but their use should be carefully considered and the minimal dose required to control the asthma employed.
authors.affiliation: Alpine Children's Hospital, Davos, Switzerland.
authors.forename: W H
authors.initials: WH
authors.lastname: Nikolaizik
authors.forename: M A
authors.initials: MA
authors.lastname: Preece
authors.forename: J O
authors.initials: JO
authors.lastname: Warner
mesh_terms: D000280:Administration, Inhalation; D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects; D019819:Budesonide / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D004702:Endocrine Glands / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000187:drug effects; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008168:Lung / Q000503:physiopathology; D008297:Male; D012129:Respiratory Function Tests; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D019382:Human Growth Hormone; D019819:Budesonide; D006854:Hydrocortisone