Mitochondrial creatine kinase--a square protein.
The recently determined structure of octameric mitochondrial creatine kinase has provided new insights into the functioning of this enzyme and its role in channelling energy from the mitochondria to the cytoplasm. Creatine kinase, a member of the family of guanidino kinases, is structurally similar to glutamine synthetase, suggesting a possible evolutionary link between both protein families.
Kabsch
W
W
Max-Planck-Institut für medizinische Forschung, Abteilung Biophysik, Heidelberg, Germany. kabsch@mpimf-heidelberg.mpg.de
Fritz-Wolf
K
K
D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D003402:Creatine Kinase / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D019143:Evolution, Molecular; D005974:Glutamate-Ammonia Ligase / Q000737:chemistry; D008928:Mitochondria / Q000201:enzymology*; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D017433:Protein Structure, Secondary
D000255:Adenosine Triphosphate; D003402:Creatine Kinase; D005974:Glutamate-Ammonia Ligase