Usefulness of a nonmachinery based system for the reinfusion of cell-free and concentrated autogenous ascitic fluid.
A nonmachinery based system using gravity dependent flow for the treatment and reinfusion of ascitic fluid was developed, and its usefulness was assessed. In a preliminary study using bovine plasma, samples with protein concentrations below 5.0 g/dl were found to be treatable with this system. Bovine plasma containing blood, prepared to 0.5% hematocrit and with a protein concentration of 3.0 g/dl, was also treatable. We conducted a clinical study of 1,799 treatment sessions (1,495 using a machinery based system and 304 using a nonmachinery based system) of 343 patients with ascites refractory to various treatments. The recovery ratio of protein from the original ascitic fluid was 96% using the nonmachinery based system and 77% with the machinery based system (p < 0.01). Of 253 continuous reinfusions of ascitic fluid using the nonmachinery based system, the original ascitic fluid at protein concentrations below 2.5 g/dl was treatable. Original ascitic fluid below a hematocrit of 0.7% (protein concentration, 1.4 g/dl) was also treatable. This new procedure was simple and time and labor saving; the high recovery ratio of protein also demonstrated the usefulness of the new system.
Katoh
S
S
Department of Internal Medicine, Murakami Memorial Hospital, Asahi University, Gifu, Japan.
Kojima
T
T
Itoh
K
K
Yoneyama
S
S
Ida
K
K
Nakaji
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001202:Ascitic Fluid / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000628:therapy; D005260:Female; D005374:Filtration / Q000295:instrumentation; D006400:Hematocrit; D006801:Humans; D007263:Infusions, Parenteral; D008103:Liver Cirrhosis / Q000473:pathology / Q000628:therapy; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010537:Peritoneum / Q000473:pathology; D011108:Polymers; D011506:Proteins / Q000032:analysis; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy; D013450:Sulfones; D016896:Treatment Outcome
D011108:Polymers; D011506:Proteins; D013450:Sulfones; C017662:polysulfone P 1700