Modulation of secondary antibody response in SRBC-immunized mice by lysozyme dimer.
The effect of lysozyme dimer (20 micrograms/kg) injected i.p. once or four times to sheep erythrocytes-immunized mice on the secondary humoral response was studied with respect to the time of exposure to the drug in relation to priming and challenge. It has been found that lysozyme dimer potentiates secondary humoral response to SRBC; as a result, the number of splenocytes producing hemolytic anti-SRBC antibodies (PFC) and anti-SRBC hemagglutinin titers, especially 2-mercaptoethanol resistant increases provided that the drug is administered after the challenge. Lysozyme dimer (both a single dose and four times' exposure to the drug) administered after priming does not affect secondary humoral response of SRBC-immunized mice.
Obmińska-Domoradzka
B
B
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Agricultural University, Wrocław, Poland.
Switała
M
M
Debowy
J
J
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D019281:Dimerization; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D007114:Immunization; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009113:Muramidase / Q000276:immunology* / Q000494:pharmacology*; D012756:Sheep
D009113:Muramidase