Proteins of the penicillin biosynthesis pathway.
Two sequential steps are common to the biosynthesis of all penicillin-derived antibiotics: the reaction of three L-amino acids to give L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine, and the oxidation of this tripeptide to give isopenicillin N. Recent studies on the peptide synthetase and oxidase enzymes responsible for these steps have implications for the mechanisms and structures of related enzymes involved in a range of metabolic processes.
Schofield
C J
CJ
Dyson Perrins Laboratory, Oxford, UK. christopher.schofield@chem.ox.ac.uk
Baldwin
J E
JE
Byford
M F
MF
Clifton
I
I
Hajdu
J
J
Hensgens
C
C
Roach
P
P
D001665:Binding Sites; D007501:Iron / Q000737:chemistry / Q000378:metabolism; D008956:Models, Chemical; D008958:Models, Molecular; D010088:Oxidoreductases / Q000737:chemistry* / Q000378:metabolism; D010406:Penicillins / Q000096:biosynthesis*; D010407:Penicillium / Q000201:enzymology*; D010453:Peptide Synthases / Q000737:chemistry* / Q000378:metabolism
D010406:Penicillins; D007501:Iron; D010088:Oxidoreductases; C038370:isopenicillin N synthetase; D010453:Peptide Synthases; C095368:alpha-aminoadipyl-cysteinyl-valine synthetase; C006414:penicillin N