title: [Malignant neuroleptic syndrome, medical-psychiatric approach].
abstract: We report the case of a 42 years old male, with a bipolar disorder and receiving lithium therapy, valproic acid and clonazepam. Due to an exacerbation of his underlying disease, he was admitted to a psychiatric clinic and received 50 mg of intramuscular chlorpromazine in two occasions. Afterwards, the patient had an alteration of consciousness, fever reaching 39 degrees C and generalized muscular rigidity. Laboratory work-up showed a normal brain CT scan, a diffuse slowness in the EEG and a creatinphosphokinase that reached values of 3.040 U/l. He was transferred to an intensive care unit and treated with sodium dantrolene and bromocriptine, obtaining a good clinical response.
authors.affiliation: Departamentos de Medicina Interna y Psiquiatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: P
authors.initials: P
authors.lastname: Giacamán
authors.forename: M
authors.initials: M
authors.lastname: Andresen
authors.forename: N
authors.initials: N
authors.lastname: Gareca
authors.forename: J
authors.initials: J
authors.lastname: Bitrán
authors.forename: A
authors.initials: A
authors.lastname: Dougnac
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis* / Q000188:drug therapy