title: Surgical strategy for the management of hilar bile duct cancer.
abstract: BACKGROUND
  Since the first attempts at resection of Klatskin tumours, an increasingly aggressive surgical treatment has been proposed. Results obtained after examination of the specimen have shown that a significant proportion of resections were palliative. Curative resection appears to be difficult to perform selectively.
  
  
  METHODS
  This retrospective study evaluates the results of a surgically-oriented management of hilar bile duct cancers. Thirty-nine patients were operated on in the period 1982-1994. Eighteen resections were carried out, requiring liver resection in 13 cases. Pathology of the specimen showed that the resection had been curative in 14 cases. The remaining 21 patients had surgical palliation, i.e. bypass and/or stenting.
  
  
  RESULTS
  In the resection group, there was no death but four patients suffered severe complications. The 1- and 5-year survival rates were 67 and 47 per cent respectively, with a median survival of 26 months. In the palliation group, the mortality rate was 14 per cent and median survival was 7 months.
  
  
  CONCLUSIONS
  In the absence of evident contraindications, surgical exploration is worthwhile as it allows detection of the cases where curative resection is possible. Curative resection often requires a major hepatectomy, but mortality and morbidity may be kept low, and it offers a real hope of cure.
authors.affiliation: Department of Digestive Surgery, Hôpital Saint-Antoine, University Paris VI, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Parc
authors.forename: P
authors.initials: P
authors.lastname: Frileux
authors.forename: P
authors.initials: P
authors.lastname: Balladur
authors.forename: E
authors.initials: E
authors.lastname: Delva
authors.forename: L
authors.initials: L
authors.lastname: Hannoun
authors.forename: R
authors.initials: R
authors.lastname: Parc
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000473:pathology / Q000601:surgery*; D000075202:Contraindications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011788:Quality of Life; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative; D016019:Survival Analysis