title: PET versus SPECT for determining myocardial tissue viability using fluorine-18-fluorodeoxyglucose.
abstract: The U.S. Food and Drug Administration regulates the manufacture and distribution of 18F-FDG. Acquisition and use of this radiopharmaceutical for myocardial imaging at our institution required approval by our Institutional Review Board. Our initial objective was to present a scientific validation for use of this radiopharmaceutical in adjudicating the "viable versus scarred myocardium question," using either a PET scanner or a gamma camera equipped with 511-keV collimators. We believe that our nuclear medicine colleagues who find themselves in a similar business/legal situation regarding the acquisition and use of 18F-FDG will find this review useful. We reviewed the literature to document the efficacy of 18F-FDG, in general, in assessing myocardial viability. We then did a literature-based comparison of PET scanner methodology versus modified gamma camera methodology for imaging 18F-FDG emissions. Imaging 18F-FDG with a modified gamma camera appears to be an effective alternative to imaging with a standard PET camera for assessing myocardial viability.
authors.affiliation: National Naval Medical Center, Nuclear Medicine Division, Bethesda, MD 20889-5600, USA.
authors.forename: F V
authors.initials: FV
authors.lastname: Schraml
authors.forename: D R
authors.initials: DR
authors.lastname: Driver
authors.forename: T
authors.initials: T
authors.lastname: Randolph
authors.forename: E D
authors.initials: ED
authors.lastname: Silverman
mesh_terms: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D015902:Gamma Cameras; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18