Terminating transcription in eukaryotes: lessons learned from RNA polymerase I.
Within the past few years, the genes encoding transcription terminator proteins for RNA polymerase I (pol I) have been cloned from organisms as diverse as yeast and mammals. The availability of terminator proteins has allowed construction of in vitro transcription systems that terminate pol I at the same sites as used in vivo and thus allows study of termination mechanisms. This has resulted in a burst of information concerning pol I termination mechanisms, which this review will attempt to summarize.
Reeder
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RH
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. rreeder@fhcrc.org
Lang
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WH
D000595:Amino Acid Sequence; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000502:physiology*; D012318:RNA Polymerase I / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D012318:RNA Polymerase I