A re-analysis of a randomized clinical trial for gastric cancer using interval censoring.
In a previous randomized clinical trial against curatively resected gastric cancer, we compared the effect of immunochemotherapy to chemotherapy and obtained significantly better survival and disease-free survival time (DFS) in a combined therapy group. Although DFS was analysed with a conventional approach in which the onset of relapse was defined as the diagnosis of relapse, we considered it necessary to re-analyse the data and compare the results of an interval-censored approach with the conventional approach, in order to examine whether the conclusion might be altered depending on the approach.
Sakamoto
J
J
Department of Surgery, Aichi Prefectural Hospital, Japan.
Teramukai
S
S
Nakazato
H
H
Ohashi
Y
Y
D018572:Disease-Free Survival; D006801:Humans; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic; D013274:Stomach Neoplasms / Q000401:mortality / Q000601:surgery; D015996:Survival Rate