Genetic analysis of dyslexia and other complex behavioral phenotypes.
In this review, we discuss recent data on the genetics of developmental dyslexia and consider broader issues involved in the search for genes influencing complex behavioral phenotypes. These issues include 1) the need for a sophisticated analysis of the phenotype and the need for interdisciplinary collaboration between geneticists and cognitive neuroscientists, 2) the likelihood of genetic heterogeneity and non-Mendelian inheritance and the necessity for linkage methods to deal with these issues, and 3) how association analyses complement linkage analyses.
Pennington
B F
BF
Department of Psychology, University of Denver, CO 80208, USA.
Smith
S D
SD
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D004410:Dyslexia / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010641:Phenotype
D005819:Genetic Markers