title: Preventive effect of bedding encasement with microfine fibers on mite sensitization.
abstract: BACKGROUND
  The indoor levels of mite allergens are known to determine the thresholds of sensitization and asthma exacerbation. However, the method for preventing mite sensitization by reducing the levels of house dust mites (HDMs) is not well established.
  
  
  OBJECTIVE
  We investigated whether mite-blocking bedding encasing made from microfine fibers can prevent infants from being sensitized to HDMs.
  
  
  METHODS
  Fifty-seven Japanese infants with atopic dermatitis who had high levels of IgE antibodies against either egg white, cow's milk, or soybean (but not against HDMs) were randomly chosen and divided into two groups. Thirty families of atopic infants (group A) were instructed to decrease HDMs by controlling the indoor environment, including bedding cleaning, whereas 27 families receiving the same instructions (group B) were further guided to use the Allerguard encasing for quilts and mattresses of all family members. We repeatedly examined Der p 1 + Der f 1 in the infants' mattresses and anti-Dermatophagoides farinae (Df) IgE in the infants' sera, and we performed skin prick tests with Df extract for 1 year.
  
  
  RESULTS
  The mite-blocking encasing markedly reduced the levels of Der p 1 + Der f 1 (3.0 microg/g dust for group A vs 0.77 microg/g dust for B, p < 0.001). It also prevented the increase in serum levels of anti-Df IgE (2.5 U/ml for group A vs 0.7 U/ml for group B, p < 0.05) and positive reactions to skin prick testing with Df extract (63% for group A vs 31% for group B, p < 0.02) over 1 year.
  
  
  CONCLUSIONS
  The bedding encasement with the mite-blocking fibers was effective for preventing atopic infants from being sensitized to HDMs, and it seems to be beneficial to modern busy housekeepers.
authors.affiliation: Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
authors.forename: H
authors.initials: H
authors.lastname: Yasueda
authors.forename: H
authors.initials: H
authors.lastname: Saito
mesh_terms: D000485:Allergens / Q000032:analysis; D000818:Animals; D039741:Antigens, Dermatophagoides; D001512:Bedding and Linens / Q000009:adverse effects* / Q000469:parasitology*; D003876:Dermatitis, Atopic / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D004391:Dust / Q000009:adverse effects; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008925:Mites / Q000276:immunology*; D012882:Skin Tests
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D004391:Dust; D006023:Glycoproteins; D007073:Immunoglobulin E