title: Genetic analysis of the actin cytoskeleton in the Drosophila ovary.
abstract: The Drosophila ovary provides a favorable model system in which to study cellular morphogenesis. The development of a mature egg involves a syncytium of 16 germline cells and over 1000 somatically derived follicle cells. Intercellular transport, stable intercellular bridges, cell migrations, cell shape changes, and specific subcellular localization of many embryonic patterning determinants contribute to egg development and require a dynamic cytoskeleton. We discuss many of the recent genetic and cell biological studies that have led to insights into how the actin cytoskeleton is assembled and regulated during the morphogenesis of the Drosophila egg.
authors.affiliation: Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
authors.forename: D N
authors.initials: DN
authors.lastname: Robinson
authors.forename: L
authors.initials: L
authors.lastname: Cooley
mesh_terms: D000199:Actins / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D001692:Biological Transport; D002448:Cell Adhesion; D003599:Cytoskeleton / Q000737:chemistry* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D009866:Oogenesis; D010053:Ovary / Q000648:ultrastructure
chemical_list: D000199:Actins