Syntheses and antifungal activity of dl-griseofulvin and its congeners. III.
Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a) = 1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.
Takeuchi
Y
Y
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Watanabe
I
I
Misumi
K
K
Irie
M
M
Hirose
Y
Y
Hirata
K
K
Yamato
M
M
Harayama
T
T
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006118:Griseofulvin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D006118:Griseofulvin