How can we use our growing understanding of gene transcription to discover effective new medicines?
Although drugs that target gene transcription are in wide therapeutic use, they were all identified on the basis of their effect on a specific biological process, such as inflammation or hormone responses, and were only subsequently shown to target transcription. The recent progress in understanding the mechanism of action of these drugs, and the mechanisms of transcriptional regulation in general, offers hope for a new generation of drugs isolated on the basis of their ability to modulate either the synthesis of transcription factors, the regulation of their activity by ligands or phosphorylation events, their protein-protein interactions or their binding to DNA.
Latchman
D S
DS
Department of Molecular Pathology, Windeyer Institute of Medical Science, University College London Medical School, UK. d.latchman@ucl.ac.uk
D004247:DNA / Q000378:metabolism; D015195:Drug Design; D008024:Ligands; D010766:Phosphorylation; D011401:Promoter Regions, Genetic; D011506:Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000138:chemical synthesis / Q000378:metabolism; D014158:Transcription, Genetic
D008024:Ligands; D011506:Proteins; D014157:Transcription Factors; D004247:DNA