Vomiting induction by ipecac syrup in dogs and ferrets.
The dog has been used as an experimental animal in emesis research. In this study, we analyzed the emetic effects of ipecac syrup using a smaller animal, the ferret, and compared its response to that of the dog. Dogs and ferrets were divided into 4 groups (n = 4, each). Each group was given either 0.1, 0.25, 0.5, or 1.0 ml/kg of ipecac syrup, and the latency and numbers of retching and vomiting were recorded. Animals given an equal volume of saline served as controls. The numbers of vomiting and retching increased dose-dependently in both dogs and ferrets, and there was no difference in latency and numbers of vomiting between them. The numbers of retching were greater in ferrets than in dogs at > or = 0.25 ml/kg. Taking these results into consideration, the ferret seems to be as useful as the dog in studies on emetic effects of ipecac syrup.
Yamashita
M
M
Department of Emergency Medicine, University of Tsukuba, Japan.
Yamashita
M
M
Tanaka
J
J
Chagi
K
K
Takeda
S
S
Kurihara
T
T
Takeda
Y
Y
Fujii
Y
Y
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004639:Emetics / Q000633:toxicity*; D005289:Ferrets; D007486:Ipecac / Q000633:toxicity*; D011930:Reaction Time; D013045:Species Specificity; D014839:Vomiting / Q000139:chemically induced*
D004639:Emetics; D007486:Ipecac