Neutrophil elastase inhibitor (ONO-5046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan-1.
ONO-5046. Na is a specific neutrophil elastase inhibitor. We investigated the in vitro effect of ONO-5046. Na on the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line (Capan-1, well differentiated adenocarcinoma). ONO-5046. Na significantly suppressed the proliferation, motility and chemotaxis at a concentration of more than 100, 10 and 1 microgram/ml of ONO-5040. Na, respectively (p < 0.005, p < 0.05 and p < 0.05, respectively). These results indicate that ONO-5046. Na may have a role in preventing the progression and metastasis of pancreatic carcinoma cells, suggesting that ONO-5046. Na may serve as an anti-cancer agent.
Kamohara
H
H
Department of Surgery II, Kumamoto University School of Medicine, Japan.
Sakamoto
K
K
Mita
S
S
An
X Y
XY
Ogawa
M
M
D000230:Adenocarcinoma / Q000473:pathology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D015842:Serine Proteinase Inhibitors; D013449:Sulfonamides; C069195:sivelestat; D019272:Leukocyte Elastase; D005998:Glycine