Ribonucleoprotein assembly: clues from spinal muscular atrophy.
Mutation or deletion of one of the two genes encoding a protein known as SMN has recently been shown to cause spinal muscular atrophy. The SMN protein has been found to be part of a multi-component complex that appears to function in the assembly of cellular ribonucleoprotein particles.
Mattaj
I W
IW
European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117, Heidelberg, Germany. mattaj@embl-heidelberg.de
D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein; D006801:Humans; D046911:Macromolecular Substances; D005810:Multigene Family; D009134:Muscular Atrophy, Spinal / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009865:Oocytes; D011110:Polymorphism, Genetic; D016601:RNA-Binding Proteins; D017411:Ribonucleoproteins, Small Nuclear / Q000378:metabolism*; D055532:SMN Complex Proteins; D014982:Xenopus laevis
D017362:Cyclic AMP Response Element-Binding Protein; C108381:GEMIN2 protein, human; D046911:Macromolecular Substances; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D017411:Ribonucleoproteins, Small Nuclear; D055532:SMN Complex Proteins