title: Comparison of radiosurgery treatment modalities based on physical dose distributions.
abstract: OBJECTIVE
  As a means of selecting the optimal stereotactic radiosurgery (SRS) treatment modality, a comparison of physical dose distributions to defined targets and nontarget brain tissue has been made for a group of test cases selected to represent a range of treatment-planning situations from small, nearly spherical volumes to large irregular volumes.
  
  
  METHODS
  Plans were developed for each case using photon beams from the Leksell Gamma Unit (LGU), multiarc bremsstrahlung photon beams from a linear accelerator (linac) and proton beams, with the objective of encompassing the target as closely as possible with the prescription isodose line, and minimizing dosage to normal tissue within the bounds of standard clinical practice. Dose-volume histograms (DVHs) were calculated for target and for nontarget brain tissue and compared for the various modalities.
  
  
  RESULTS
  In general, protons delivered less dosage to normal brain than other modalities for large and peripheral lesions and LGU plans were more successful at conforming to highly irregular shapes than conventional linac plans.
  
  
  CONCLUSIONS
  Differences were observed to depend on treatment modality, target characteristics (shape, size and location), and the amount of effort expended on treatment planning and the time allotted for treatment implementation.
authors.affiliation: Department of Radiation Oncology, University of California, San Francisco 94143-0226, USA. verhey@randonc4.ucsf.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: Verhey
authors.forename: V
authors.initials: V
authors.lastname: Smith
authors.forename: C F
authors.initials: CF
authors.lastname: Serago
mesh_terms: D001254:Astrocytoma / Q000601:surgery; D001921:Brain / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000556:secondary / Q000601:surgery*; D005909:Glioblastoma / Q000601:surgery; D005910:Glioma / Q000601:surgery*; D006801:Humans; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted