title: Blood coagulation activity during microsurgery.
abstract: The authors investigated blood coagulation activity in patients who underwent microsurgery. Hemostatic parameters were measured in 9 patients (10 operations) who were undergoing free tissue transfers. These parameters included prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinopeptide A (FPA), prothrombin fragment 1 + 2 (F1 + 2), and thrombin-antithrombin complex (TAT). The flap totally necrosed owing to vasospasm in 1 patient with osteomyelitis of the heel, and the FPA, F1 + 2, and TAT values significantly increased. Reexploration was required because of flap cyanosis in 1 patient with a hemangioma on the wrist, and the F1 + 2 and TAT values increased during the salvage procedure. These molecular markers could be important in indicating hypercoagulable state sensitivity, and they serve as a warning of possible vascular compromise to a surgeon.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Tokyo Metropolitan Police Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Komuro
authors.forename: J
authors.initials: J
authors.lastname: Sekiguchi
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: K
authors.initials: K
authors.lastname: Ohmori
authors.forename: Y
authors.initials: Y
authors.lastname: Takasugi
authors.forename: C
authors.initials: C
authors.lastname: Arai
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D001780:Blood Coagulation Tests; D005260:Female; D006488:Hemostasis, Surgical; D006801:Humans; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D009336:Necrosis; D011183:Postoperative Complications / Q000209:etiology; D013524:Surgical Flaps / Q000098:blood supply; D013927:Thrombosis / Q000209:etiology