title: Ocular hypotensive effect of pilocarpine before and after argon laser trabeculoplasty.
abstract: OBJECTIVE
  The purpose of this study was to compare the hypotensive response of human glaucomatous eyes to 1% pilocarpine solution before and after argon laser trabeculoplasty.
  
  
  METHODS
  We designed a prospective, 'repeated measures' study comparing the ocular hypotensive effect of acutely administered 1% pilocarpine solution in 30 medically uncontrolled glaucomatous eyes, before and after argon laser trabeculoplasty.
  
  
  RESULTS
  The pilocarpine-induced IOP decrease was 3.6 +/- 0.59 mmHg before argon laser trabeculoplasty, and 1.8 +/- 0.53 mmHg after laser therapy. In both instances, the pilocarpine hypotensive effect was significantly correlated with pretreatment IOP (p = 0.02, r = 0.41 before argon laser trabeculoplasty, and p = 0.003, r = 0.52 after argon laser trabeculoplasty). We built a 'repeated measurements ANCOVA' model, and found no statistically significant difference between the pilocarpine IOP lowering effect before and after argon laser trabeculoplasty (p = 0.4).
  
  
  CONCLUSIONS
  Argon laser trabeculoplasty does not modify the IOP lowering effect of 1% pilocarpine solution.
authors.affiliation: Príncipe de Asturias Hospital, University of Alcalá de Henares, Madrid, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Teus
authors.forename: M A
authors.initials: MA
authors.lastname: Castejón
authors.forename: M A
authors.initials: MA
authors.lastname: Calvo
authors.forename: M A
authors.initials: MA
authors.lastname: Fagúndez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage*; D011446:Prospective Studies; D014130:Trabeculectomy / Q000379:methods*
chemical_list: D018721:Muscarinic Agonists; D009883:Ophthalmic Solutions; D010862:Pilocarpine