title: Effect of dietary insoluble fiber on control of glycemia in dogs with naturally acquired diabetes mellitus.
abstract: OBJECTIVE
  To evaluate the effect of a high insoluble-fiber (HF) diet containing 12% cellulose in dry matter and a low insoluble-fiber (LF) diet on control of glycemia in dogs with naturally acquired insulin-dependent diabetes mellitus.
  
  
  METHODS
  Prospective randomized crossover controlled trial.
  
  
  METHODS
  11 dogs with naturally acquired diabetes mellitus.
  
  
  METHODS
  Dogs were fed HF and LF diets for 8 months each in 1 of 2 randomly assigned diet sequences. Caloric intake and insulin treatment were adjusted as needed to maintain stable body weight and control of glycemia, respectively. After a 2-month adaptation period, control of glycemia was evaluated every 6 weeks for 6 months. Variables assessed included serum glucose concentration measured during the preprandial state, blood glycosylated hemoglobin concentration, serum glucose concentration measured every 2 hours for 24 hours beginning at the time of the morning insulin injection, 24-hour mean serum glucose concentration, mean serum glucose concentration fluctuation from the 24-hour mean serum glucose concentration, and 24-hour urinary excretion of glucose.
  
  
  RESULTS
  Significant differences in mean daily caloric intake, body weight, or daily insulin dosage among dogs fed HF and LF diets were not found. Mean preprandial serum glucose concentration, most postprandial serum glucose concentrations, 24-hour mean serum glucose concentration, and 24-hour urinary excretion of glucose were significantly lower in dogs fed the HF diet, compared with the LF diet.
  
  
  CONCLUSIONS
  Results of this study support feeding of commercially available insoluble fiber diets to dogs with naturally acquired diabetes mellitus.
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616-8734, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Nelson
authors.forename: C A
authors.initials: CA
authors.lastname: Duesberg
authors.forename: S L
authors.initials: SL
authors.lastname: Ford
authors.forename: E C
authors.initials: EC
authors.lastname: Feldman
authors.forename: D J
authors.initials: DJ
authors.lastname: Davenport
authors.forename: C
authors.initials: C
authors.lastname: Kiernan
authors.forename: L
authors.initials: L
authors.lastname: Neal
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D018592:Cross-Over Studies; D003922:Diabetes Mellitus, Type 1 / Q000178:diet therapy / Q000662:veterinary*; D004043:Dietary Fiber / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000178:diet therapy* / Q000517:prevention & control; D004285:Dogs; D005260:Female; D006943:Hyperglycemia / Q000517:prevention & control / Q000662:veterinary*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D011446:Prospective Studies; D016037:Single-Blind Method; D012995:Solubility
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D007004:Hypoglycemic Agents; D007328:Insulin