title: [Thymic and bronchial neuroendocrine tumors in multiple endocrine neoplasia type 1. GENEM1].
abstract: OBJECTIVE
  Multiple endocrine neoplasia type 1 (MEN 1) mainly affects parathyroid glands, pancreatic islets and pituitary gland. The aim of this study in 95 MEN 1 patients was to examine less frequent localizations thymic and bronchic neuroendocrine tumors (NET).
  
  
  METHODS
  Two cases of bronchic NET were observed, both in women, and 4 cases of thymic NET, all in men, giving a prevalence of 7.3%. These NET were often asymptomatic. A metastatic diffusion was observed in 3 cases. Elevated plasma levels of glycoprotein hormone alpha subunit (SU) and FSH were observed in 3 and 1 cases respectively. Immunohistochemistry indicated the tumor cells to be frequently positively stained for HCG alpha and FSH.
  
  
  CONCLUSIONS
  We conclude that all patients with MEN 1 should undergo screening for thoracic NET, especially in high risk familial subgroups and in case of elevated plasma alpha SU or FSH.
authors.affiliation: Clinique d'Endocrinologie, Hôtel-Dieu, Nantes.
authors.forename: A
authors.initials: A
authors.lastname: Murat
authors.forename: M F
authors.initials: MF
authors.lastname: Heymann
authors.forename: S
authors.initials: S
authors.lastname: Bernat
authors.forename: B
authors.initials: B
authors.lastname: Dupas
authors.forename: A Y
authors.initials: AY
authors.lastname: Delajartre
authors.forename: A
authors.initials: A
authors.lastname: Calender
authors.forename: P
authors.initials: P
authors.lastname: Despins
authors.forename: J L
authors.initials: JL
authors.lastname: Michaud
authors.forename: S
authors.initials: S
authors.lastname: Giraud
authors.forename: M F
authors.initials: MF
authors.lastname: Le Bodic
authors.forename: B
authors.initials: B
authors.lastname: Charbonnel
mesh_terms: D000328:Adult; D001984:Bronchial Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000276:immunology / Q000503:physiopathology*; D011446:Prospective Studies; D012189:Retrospective Studies; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*
vernacular_title: Tumeurs neuro-endocrines thymiques et bronchiques au cours des néoplasies endocrines multiples de type 1. GENEM1.