title: Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine.
abstract: We compared immune responses to intranasal and intramuscular DNA vaccinations against human immunodeficiency virus type 1 with monophosphoryl lipid A (MPL) used as an adjuvant. Both routes of vaccination resulted in similar levels of cell-mediated immunity, but the intestinal secretory immunoglobulin A response was higher following intranasal immunization than after intramuscular immunization. MPL demonstrated its adjuvanticity in vaccination by both routes.
authors.affiliation: Department of Bacteriology, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Hamajima
authors.forename: J
authors.initials: J
authors.lastname: Fukushima
authors.forename: A
authors.initials: A
authors.lastname: Ihata
authors.forename: N
authors.initials: N
authors.lastname: Ishii
authors.forename: I
authors.initials: I
authors.lastname: Gorai
authors.forename: F
authors.initials: F
authors.lastname: Hirahara
authors.forename: H
authors.initials: H
authors.lastname: Mohri
authors.forename: K
authors.initials: K
authors.lastname: Okuda
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage* / Q000276:immunology; D000281:Administration, Intranasal; D000818:Animals; D002772:Cholera Toxin / Q000008:administration & dosage; D015483:HIV Antibodies / Q000096:biosynthesis; D015497:HIV-1 / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D018928:Immunity, Mucosal; D007114:Immunization; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis; D007273:Injections, Intramuscular; D008050:Lipid A / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051379:Mice; D008807:Mice, Inbred BALB C; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D015483:HIV Antibodies; D007071:Immunoglobulin A, Secretory; D008050:Lipid A; D019444:Vaccines, DNA; D002772:Cholera Toxin; C048436:monophosphoryl lipid A