title: Induction of apoptosis in human stomach cancer cells by green tea catechins.
abstract: The exposure of human stomach cancer KATO III cells to green tea catechin extract and epigallocatechin gallate (EGCG), a main component of the extract led to both growth inhibition and the induction of programmed cell death (apoptosis). Morphological changes showing apoptotic body were observed in the cells treated with green tea catechin extract and EGCG. The fragmentation of DNA to oligonucleosomal-sized fragments, characteristic of apoptosis was determined to be concentration- and time-dependent. These data suggest that drinking of green tea in large amounts is recommended possibly to protect humans from stomach cancer.
authors.affiliation: Faculty of Medicine, Mie University, Tsu-city, Mie 514, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hibasami
authors.forename: T
authors.initials: T
authors.lastname: Komiya
authors.forename: Y
authors.initials: Y
authors.lastname: Achiwa
authors.forename: K
authors.initials: K
authors.lastname: Ohnishi
authors.forename: T
authors.initials: T
authors.lastname: Kojima
authors.forename: K
authors.initials: K
authors.lastname: Nakanishi
authors.forename: K
authors.initials: K
authors.lastname: Akashi
authors.forename: Y
authors.initials: Y
authors.lastname: Hara
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010936:Plant Extracts; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*; D013662:Tea; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate