Cancer chemoprevention: some complications and limitations.
Chemopreventive strategies are very attractive and have earned serious consideration as a potential means of controlling cancer incidence. However, the use of some anti-initiating entities (enzyme inducers or inhibitors) devised to reduce tumor initiation is controversial. Indeed, considering the double-edged-sword (activating or detoxifying) nature of drug metabolizing enzymes, any attempt to modulate such catalysts by dietary components (including drugs) may lead to cancer risk.
Paolini
M
M
Department of Pharmacology, University of Bologna, Italy.
Mesirca
R
R
Pozzetti
L
L
Gialluca
N
N
Bauer
C
C
Biagi
G L
GL
Cantelli-Forti
G
G
D000818:Animals; D016588:Anticarcinogenic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008658:Inactivation, Metabolic; D009369:Neoplasms / Q000517:prevention & control*
D016588:Anticarcinogenic Agents; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D003577:Cytochrome P-450 Enzyme System