Sequence of four new HLA-Cw alleles: a possible role of interallelic recombination.
In order to extend our current understanding of HLA-C polymorphism, four new alleles have been cloned and sequenced: Cw*1801 in a donor of mixed origin, Cw*02024 in a Senegalese individual, Cw*1205 and Cw*1604 in European Caucasoid blood donors. HLA-Cw*1801, which most likely results from an interallelic recombination between Cw*0704 and 0401 alleles, was not associated with B*8101, but with either B*4403 or B18. The Cw*02024 allele differs from Cw*02022 by a silent mutation in exon 3. Both Cw*1801 and Cw*02024 appear to be rather frequent in populations of African origin but have not yet been detected in Caucasoids. HLA-Cw*1604 differs from Cw*1601 by two nucleotides at codon 156 leading to a Gln to Trp substitution. This new Cw16 subtype was subsequently identified in three additional unrelated families, all of South-European origin, and presented an unusual association with B*4402 in all cases. HLA-Cw*1205 is a composite allele with the alpha1 domain of Cw*1602 and the alpha2 domain of Cw*1203. It appears to be rare, at least in European Caucasoids. Three of these four alleles may have resulted from gene conversion-like or interallelic recombination events.
Grundschober
C
C
Transplantation Immunology Unit, Division of Immunology and Allergology, HUG, Geneva, Switzerland.
Labonne
M P
MP
Javaux
F
F
Steiner
Q G
QG
Gebuhrer
L
L
Tiercy
J M
JM
D000483:Alleles; D000595:Amino Acid Sequence; D000951:Antigens, Neoplasm; D001483:Base Sequence; D001782:Blood Donors; D018076:DNA, Complementary; D005060:Europe / Q000208:ethnology; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D058950:Melanoma-Specific Antigens; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D044465:White People / Q000235:genetics*
D000951:Antigens, Neoplasm; D018076:DNA, Complementary; D015236:HLA-C Antigens; C072011:MAGEA1 protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins