Gammadelta T cells in host defense and epithelial cell biology.
Recent studies have demonstrated increased numbers of gammadelta T cells in a variety of human infectious as well as noninfectious diseases. In some cases gammadelta T cells could be shown to destroy infected or transformed cells. Advances in the identification of ligands recognized by gammadelta T cells and the development of animal model systems to study these cells in vivo should overcome some of the major obstacles currently preventing a better understanding of gammadelta T cell function in immune responses. As we gain this knowledge it may become possible to design therapeutic strategies exploiting unique properties of gammadelta T cells to promote more effective immunity.
Boismenu
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The Scripps Research Institute, La Jolla, California 92037, USA.
Havran
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D000818:Animals; D004195:Disease Models, Animal; D004848:Epithelium / Q000276:immunology; D006801:Humans; D007109:Immunity; D007239:Infections / Q000276:immunology*; D018448:Models, Immunological; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta