Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix.
OBJECTIVE
To evaluate the estrogen and progesterone receptor status of glassy cell carcinoma of the cervix to assess the possible implications of hormone replacement therapy in these patients.


METHODS
The estrogen and progesterone receptor status of 13 glassy cell carcinomas was evaluated by immunohistochemistry using commercial monoclonal antibodies and a streptavidin-biotin detection system.


RESULTS
No immunohistochemically detectable estrogen or progesterone receptor protein was present in tumor cells, although both receptors were identified in the adjacent normal cervical tissue.


CONCLUSIONS
The absence of estrogen and progesterone receptors in glassy cell carcinoma suggests that this tumor would not be hormonally responsive and that these patients can be safely treated with hormone replacement therapy. Further studies are indicated to confirm this observation.
Atlas
I
I
Department of Pathology and Laboratory Medicine, Women and Infants' Hospital, Brown University, Providence, Rhode Island 02905, USA.
Gajewski
W
W
Falkenberry
S
S
Granai
C O
CO
Steinhoff
M M
MM
D000328:Adult; D001706:Biopsy; D018196:Carcinoma, Adenosquamous / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015914:Estrogen Replacement Therapy / Q000592:standards*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone