Rhabdomyolysis after taking atorvastatin with gemfibrozil.
The findings in this case indicate that atorvastatin, like other DL-3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, may increase the risk of myositis and rhabdomyolysis when used in combination with gemfibrozil.
Duell
P B
PB
Department of Medicine, Oregon Health Sciences University, Portland 97201-3098, USA.
Connor
W E
WE
Illingworth
D R
DR
D000328:Adult; D000069059:Atorvastatin; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D015248:Gemfibrozil / Q000627:therapeutic use*; D006538:Heptanoic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000009:adverse effects* / Q000627:therapeutic use; D015228:Hypertriglyceridemia / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D011758:Pyrroles / Q000009:adverse effects* / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000139:chemically induced*
D006538:Heptanoic Acids; D000960:Hypolipidemic Agents; D011758:Pyrroles; D000069059:Atorvastatin; D006903:Hydroxymethylglutaryl CoA Reductases; D015248:Gemfibrozil