title: Further parameters of insight and neuropsychological deficit in schizophrenia and other chronic mental disease.
abstract: Evidence has begun to accumulate which suggests that lack of awareness of illness in schizophrenia is related to and possibly the result of a cognitive deficit involving prefrontal cerebral dysfunction. This study further explores this relationship along with other domains of self-awareness in chronic schizophrenics and other subjects with serious mental disorders. One hundred eight schizophrenics and 21 bipolar subjects from three separate sites in Britain, Germany, and Canada were administered the Wisconsin Card Sorting Test and three measures of self-awareness. Lack of illness awareness and other domains of self-knowledge were significantly more related to poorer neuropsychological performance in schizophrenia patients than in the other subjects. The results support the hypothesis that lack of illness awareness is related to defective frontal lobe functioning as indexed by neuropsychological measures.
authors.affiliation: Queen Street Mental Health Center, Toronto, Ontario, Canada.
authors.forename: D A
authors.initials: DA
authors.lastname: Young
authors.forename: K K
authors.initials: KK
authors.lastname: Zakzanis
authors.forename: C
authors.initials: C
authors.lastname: Bailey
authors.forename: R
authors.initials: R
authors.lastname: Davila
authors.forename: J
authors.initials: J
authors.lastname: Griese
authors.forename: G
authors.initials: G
authors.lastname: Sartory
authors.forename: A
authors.initials: A
authors.lastname: Thom
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000553:Ambulatory Care; D001364:Awareness; D001714:Bipolar Disorder / Q000175:diagnosis / Q000523:psychology; D010054:Brief Psychiatric Rating Scale / Q000706:statistics & numerical data; D002908:Chronic Disease; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D015331:Cohort Studies; D005625:Frontal Lobe / Q000503:physiopathology; D006304:Health Status; D006760:Hospitalization; D006801:Humans; D008950:MMPI; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000523:psychology; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index