Role of tumor necrosis factor alpha in the host response of mice to bacteremia caused by pneumolysin-deficient Streptococcus pneumoniae.
Pneumolysin-deficient mutant strains of Streptococcus pneumoniae are known to cause less-severe sepsis than wild-type pneumococcal strains that produce pneumolysin. This difference is associated with greater host resistance in mice infected with the pneumolysin-deficient strains. These studies show that the host resistance developed during the first 1 to 2 days after infection with a pneumolysin-deficient mutant strain is dependent on tumor necrosis factor alpha but is apparently independent of interleukin 1beta (IL-1beta) or IL-6. Survival beyond 5 days appeared to depend on the ability of the mice to produce IL-1beta.
Benton
K A
KA
Department of Microbiology, The University of Alabama at Birmingham, 35294, USA.
VanCott
J L
JL
Briles
D E
DE
D000818:Animals; D016470:Bacteremia / Q000276:immunology*; D001426:Bacterial Proteins; D007375:Interleukin-1 / Q000097:blood / Q000502:physiology; D015850:Interleukin-6 / Q000097:blood; D051379:Mice; D008808:Mice, Inbred CBA; D011008:Pneumococcal Infections / Q000276:immunology*; D013301:Streptolysins / Q000172:deficiency*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000502:physiology*
D001426:Bacterial Proteins; D007375:Interleukin-1; D015850:Interleukin-6; D013301:Streptolysins; D014409:Tumor Necrosis Factor-alpha; C032290:plY protein, Streptococcus pneumoniae