Prenatal diagnosis of trisomy 18 at the 10-14-week ultrasound scan.
A beneficial consequence of screening for trisomy 21 by a combination of maternal age and fetal nuchal translucency thickness (NT) at 10-14 weeks is the early diagnosis of trisomy 18. In a multicenter study of 91,091 singleton pregnancies there were 106 fetuses with trisomy 18 and 83% were identified by NT screening. Trisomy 18 was also associated with early onset intrauterine growth retardation, decreased fetal heart rate and the presence of exomphalos.
Sherod
C
C
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.
Sebire
N J
NJ
Soares
W
W
Snijders
R J
RJ
Nicolaides
K H
KH
D000293:Adolescent; D000328:Adult; D002887:Chromosomes, Human, Pair 18; D019160:Endosonography; D005094:Exophthalmos / Q000000981:diagnostic imaging; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000235:genetics / Q000503:physiopathology; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014314:Trisomy / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D016216:Ultrasonography, Prenatal; D014621:Vagina / Q000000981:diagnostic imaging