[Autophosphorylation in regulation of activity of cAMP-dependent protein kinases from spleen lymphocytes under ionizing radiation].
It was found that the irradiation in doses 0.5 and 1 Gy does not make any essential effect on the process of the autophosphorylation of cAMP-dependent protein kinases, extracted from the spleen lymphocytes 12 hours after exposure to the radiation. However, the decrease in the affinity of the holoenzyme to the cyclic nucleotide was found. The increase of the dose leads to the intensity of the effect (0.5 Gy--1.5 times decrease, 1 Gy--3 times decrease).
Ostapchenko
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D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism* / Q000528:radiation effects; D004789:Enzyme Activation / Q000528:radiation effects; D008297:Male; D010766:Phosphorylation; D051381:Rats; D013154:Spleen / Q000276:immunology / Q000528:radiation effects*; D013601:T-Lymphocytes / Q000201:enzymology* / Q000528:radiation effects
D017868:Cyclic AMP-Dependent Protein Kinases
Rol' avtofosforilirovaniia vreguliatsii aktivnosti cAMP-zavisimykh proteinkinaz iz limfotsitov selezenki krys v usloviiakh vzaimodełstviia ioniziruiushcheł radiatsii.