[Changes in the cytokine concentration during immunotherapy of superficial bladder tumors].
A growing number of data support the importance of urinary cytokines in the BCG immunotherapy of superficial bladder tumours. To investigate kinetics and stability, urinary levels of IL-8, IL-2 and IL-6 cytokines after BCG treatment, were determined. Significant elevation in the level of IL-8 was established immediately following the first BCG instillation and it reached its highest value 4-6 hours after the treatment. During the first three weeks of the treatment and follow-up period IL-8 peaked significantly earlier than IL-2 or IL-6. Its early appearance associated with high stability makes IL-8 a good candidate for being considered as an effective agent with high predictive value in BCG immunotherapy.
Somogyi
L
L
Pécsi Orvostudományi Egyetem Urológiai Klinika, Pécs.
de Boer
E C
EC
de Ruiter
G J
GJ
de Reijke
T M
TM
Kurth
K H
KH
Schamhart
D H
DH
D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology; D002278:Carcinoma in Situ / Q000276:immunology* / Q000628:therapy / Q000652:urine; D016207:Cytokines / Q000652:urine*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000628:therapy / Q000652:urine
D001500:BCG Vaccine; D016207:Cytokines
Vizelet cytokinek koncentrációjának változása felületes hólyagdaganatok immunterápiája során.