title: Castleman's disease in a 44-year-old male with neurofibromatosis and pheochromocytoma.
abstract: A case of Castleman's disease in a patient with type I neurofibromatosis and pheochromocytoma is reported. The association of pheochromocytoma and neurofibromatosis is well documented, but uncommon. Castleman's disease has not been previously documented in a patient with neurofibromatosis or pheochromocytoma and may represent a previously unrecognized association of this disease. Castleman's disease is an interleukin-6 (IL-6) mediated B-cell proliferation. We postulate a relationship between pheochromocytoma IL-6 secretion and Castleman's disease. The relevant literature relating to this unusual case is reviewed.
authors.affiliation: Department of Medicine, The Toronto Hospital, Ontario, Canada.
authors.forename: H T
authors.initials: HT
authors.lastname: Stelfox
authors.forename: A K
authors.initials: AK
authors.lastname: Stewart
authors.forename: D
authors.initials: D
authors.lastname: Bailey
authors.forename: D
authors.initials: D
authors.lastname: Harrison
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D001402:B-Lymphocytes / Q000502:physiology; D005871:Castleman Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D010673:Pheochromocytoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D015850:Interleukin-6