[Immunization against a new, infrequent alloantigen (Iy) on the platelet glycoprotein Ib/IX as a cause of a serious case of neonatal alloimmune thrombocytopenia].
Neonatal alloimmune thrombocytopenia is the consequence of maternal alloimmunization against platelet-specific alloantigens, usually PIA1 or Br(a). The clinical picture is characterized by signs of haemorrhagic diathesis as a result of marked thrombocytopenia. In the last years, rare cases of immunization against 'low-frequency' or 'private' platelet alloantigens on the platelet glycoprotein (GP) complex IIb/IIIa have been found. This is the first report on NAIT due to maternal immunization against a low-frequency platelet alloantigen ('Iy') localized on platelet GP Ib/IX.
Kiefel
V
V
Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen, Deutschland.
Vicariot
M
M
Breitfeld
C
C
Giptner
A
A
Schlüter
C
C
Böhringer
M
M
Santoso
S
S
Kroll
H
H
Mueller-Eckhardt
C
C
D016824:Antigens, Human Platelet / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology*; D011247:Pregnancy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*
C110429:12bw alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies; D019038:Platelet Glycoprotein GPIb-IX Complex
Immunisierung gegen ein neues, niedrigfrequentes Alloantigen (Iy) auf dem thrombozytären Glykoprotein Ib/IX als Ursache für einen schweren Fall von neonataler Alloimmunthrombozytopenie.