title: [Preliminary results of a prospective randomized clinical study on the comparison of solvent- and detergent-inactivated plasma (SDP-TNBT/Triton X-100) and untreated fresh-frozen plasma].
abstract: We report on preliminary results of a randomised clinical study comparing solvent/detergent-inactivated plasma to untreated FFP. Factors V, VII, VIII:C and protein S in the plasma units and in 14 patients were determined. Additionally, we measured prothrombin fragments 1,2, fibrin monomers, D-dimers, thrombin-antithrombin III, plasmin-antiplasmin complexes and fibrinogen degradation products as markers of activated coagulation (MAC), and calculated ratios of MACpost/ MACpre. One batch of SD plasma (SDP 797) with very high FVII and very low protein S seemed to produce significant changes in vivo without any clinical relevance. The bad quality of this batch could be due to virus inactivation in the early phase of large-scale routine production from a plasma pool that was too small.
authors.affiliation: Abteilung für Transfusionsmedizin und Gerinnungsphysiologie, Universitätsklinikum Marburg, Deutschland.
authors.forename: Y
authors.initials: Y
authors.lastname: Mortelmans
authors.forename: K H
authors.initials: KH
authors.lastname: Beck
authors.forename: V
authors.initials: V
authors.lastname: Kretschmer
mesh_terms: D001779:Blood Coagulation Factors / Q000032:analysis; D016913:Blood Component Transfusion / Q000379:methods; D003902:Detergents; D006801:Humans; D017830:Octoxynol; D010949:Plasma; D012997:Solvents
chemical_list: D001779:Blood Coagulation Factors; D003902:Detergents; D012997:Solvents; D017830:Octoxynol
vernacular_title: Erste Ergebnisse einer prospektiven randomisierten klinischen Studie zum Vergleich von Solvent-Detergent-inaktiviertem Plasma (SDP-TNBP/Triton X-100) und unbehandeltem Fresh-frozen-Plasma.