Clinical implications of blood substitutes.
Red cell substitutes are developing rapidly and progressing in their clinical testing. The original concept of a shelf storable oxygen carrying solution for use in trauma and other emergency situations still remains valid. Of interest is the potential for red cell substitutes to be used in other areas of surgery, traditionally the realm of autologous transfusion. This article describes some of the logic behind defining which areas of application are potentially useful in the surgical arena.
Greenburg
A G
AG
Brown University School of Medicine, The Miriam Hospital, Department of Surgery, Providence, Rhode Island 02906, USA.
D001802:Blood Substitutes / Q000627:therapeutic use*; D001804:Blood Transfusion, Autologous; D017558:Elective Surgical Procedures; D017707:Erythrocyte Transfusion; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D013514:Surgical Procedures, Operative
D001802:Blood Substitutes; D006454:Hemoglobins