Separation of enantiomers of drugs by capillary electrophoresis. V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent.
In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-alpha-cyclodextrin as chiral solvating agent (CSA). A total of 34 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a correlation of the separation factors alpha(m) with the interaction strengths Rm. As shown for a subset of 23 drugs, the concentration of the CSA is a crucial parameter for further optimization.
Koppenhoefer
B
B
Institute for Organic Chemistry, University of Tübingen, Germany.
Epperlein
U
U
Schlunk
R
R
Zhu
X
X
Lin
B
B
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D013237:Stereoisomerism; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004364:Pharmaceutical Preparations; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; C479658:hydroxypropyl-alpha-cyclodextrin; D000073738:2-Hydroxypropyl-beta-cyclodextrin