title: A clinical assessment of the effectiveness of a mouthwash based on triclosan and on Zea mays L used as supplements to brushing.
abstract: The effectiveness of a mouthwash based on triclosan in combatting plaque and gingivitis was compared with a mouthwash based on nonsaponifiable maize germ (Zea mays L). Both were used to supplement conventional mechanical oral hygiene. The study was carried out under double-blind conditions with a negative control (a placebo) and a positive control (a mouthwash based on chlorhexidine). After a period of 14 days to allow the Plaque Index and Gingival Index to standardize, the 43 subjects who formed the sample were examined weekly for 3 weeks. During the study, five subjects were excluded because they did not meet the criteria for selection for the study. Although the mouthwash based on triclosan reduced the Plaque Index by 7.3% in comparison with the placebo negative control (a less marked effect than that of chlorhexidine, which achieved an 8.43% reduction), it had scarcely any effect on the Gingival Index. The mouthwash based on Zea mays L had no beneficial action on the Plaque Index, which increased slightly, but it led to an improvement in the Gingival Index (7.17% in comparison with the placebo).
authors.affiliation: Department of Oral Medicine and Periodontics, Faculty of Dentistry, University of Seville, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Machuca
authors.forename: S
authors.initials: S
authors.lastname: Valencia
authors.forename: J R
authors.initials: JR
authors.lastname: Lacalle
authors.forename: C
authors.initials: C
authors.lastname: Machuca
authors.forename: P
authors.initials: P
authors.lastname: Bullon
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D010940:Plant Proteins / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D014099:Toothbrushing; D014260:Triclosan / Q000627:therapeutic use*; D003313:Zea mays
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D010940:Plant Proteins; D014260:Triclosan; D002710:Chlorhexidine