title: Transitional cell carcinoma of the prostate: clinicopathologic study of 50 cases.
abstract: BACKGROUND
  This study was performed to identify clinical and histologic features most significant in predicting outcome in patients with transitional cell carcinoma (TCC) of the prostate without invasive bladder carcinoma.
  
  
  METHODS
  The histologic and clinical material from 50 patients with prostatic TCC without invasive bladder carcinoma were studied. The tumors were divided into the following locoregional categories: 1) TCC in situ (CIS) of the prostatic urethra; 2) CIS of the prostatic ducts and acini; 3) TCC with stromal invasion; 4) TCC with extraprostatic extension and/or seminal vesicle involvement; and 5) lymph node metastases. The Kaplan-Meier method was used to generate survival distributions for the locoregional categories, and comparison of survival curves was accomplished with the log rank test.
  
  
  RESULTS
  The 5-year disease specific survival rate was 52%. The 5-year disease specific survival rates for the locoregional categories were as follows: CIS of the prostatic urethra and prostatic ducts and acini (n = 19), 100%; TCC with stromal invasion (n = 21), 45%; TCC with extraprostatic extension and seminal vesicle involvement (n = 3), 0%; and lymph node metastases (n = 7), 30%. There was a significant difference in disease specific survival when patients with CIS were compared with patients with stromal invasion, extraprostatic extension and seminal vesicle involvement, and lymph node metastases (P = 0.0001).
  
  
  CONCLUSIONS
  This study demonstrates that patients with prostatic TCC involving prostatic stroma, extraprostatic tissues, seminal vesicles, and lymph nodes have a significantly poorer 5-year disease specific survival than patients with CIS.
authors.affiliation: Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Cheville
authors.forename: P A
authors.initials: PA
authors.lastname: Dundore
authors.forename: D G
authors.initials: DG
authors.lastname: Bostwick
authors.forename: M M
authors.initials: MM
authors.lastname: Lieber
authors.forename: K P
authors.initials: KP
authors.lastname: Batts
authors.forename: T J
authors.initials: TJ
authors.lastname: Sebo
authors.forename: G M
authors.initials: GM
authors.lastname: Farrow
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D016019:Survival Analysis