title: [Selective stabilization of AT-rich DNA duplexes by oligodeoxyribonucleotide conjugates with distamycin analogues].
abstract: Oligodeoxyribonucleotide conjugates with distamycin analogues containing up to five pyrrolecarboxamide moieties were synthesized. The stability of duplexes formed by these conjugates was shown to depend directly upon the number of pyrrolecarboxamide moieties in the ligand molecule. For the duplexes formed by octaadenylate and octathymidilate conjugates with the distamycin pentapyrrole analogue, stability was demonstrated to be achieved by either one or two ligand molecules; however, duplexes containing two ligand molecules are more stable.
authors.forename: A N
authors.initials: AN
authors.lastname: Siniakov
authors.forename: V A
authors.initials: VA
authors.lastname: Riabinin
authors.forename: S V
authors.initials: SV
authors.lastname: Seregin
authors.forename: S G
authors.initials: SG
authors.lastname: Lokhov
authors.forename: I V
authors.initials: IV
authors.lastname: Kutiavin
authors.forename: H B
authors.initials: HB
authors.lastname: Gamper
authors.forename: R B
authors.initials: RB
authors.lastname: Mayer
mesh_terms: D004247:DNA / Q000737:chemistry; D004214:Distamycins / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D004214:Distamycins; D008024:Ligands; D009838:Oligodeoxyribonucleotides; D011758:Pyrroles; C030000:stallimycin; D004247:DNA
vernacular_title: Selektivnaya stabilizatsiya AT-bogatykh DNK-dupleksov kon''iugatami oligodezoksiribonuleotidov i analogov distamitsina.