Effect of some Sitavirya drugs on gastric secretion and ulceration.
Four Sitavirya plants viz. Satavari (fresh root juice, 1250 mg/kg), Yastimadhu (water decoction of root, 600 mg/kg), Kutaja and Aswattha (water decoctions of bark; 400 and 500 mg/kg respectively) were studied for their effects on different models of gastroduodenal ulcers in rats, when given orally for 3 days. All of them were found to protect the animals against 2 hr cold restraint stress and pylorus ligation-induced gastric and cysteamine-induced duodenal ulcers. However, they were ineffective against acute aspirin-induced gastric ulcers. The antiulcerogenic effect could be due to their inhibitory effect on offensive acid-pepsin secretion and augmentation of mucosal defensive factors in terms of enhanced mucin secretion and decreased cell shedding.
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Department of Dravyaguna, Banaras Hindu University, Varanasi, India.
Maiti
R N
RN
Joshi
V K
VK
Agrawal
V K
VK
Goel
R K
RK
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010437:Peptic Ulcer / Q000188:drug therapy*; D010946:Plants, Medicinal; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
D000897:Anti-Ulcer Agents