[Changes of some physicochemical parameters of gas exchange in aqueous humor of rabbits during treatment of experimental uveitis].
OBJECTIVE
To evaluate the usefulness of some parameters of the aqueous humor: pH, pO2 (oxygen pressure), pCO2 (carbon dioxide pressure) and HCO3- concentration in the diagnosis of uveitis. Changes of these parameters following conventional treatment and cryotherapy have also been investigated.


METHODS
We used 40 grey rabbits (weighing 2.5-3.0 kg). Uveitis was evoked by intravitreal injection of 5 mg of animal albumin. Cryotherapy was performed by transconjunctival, quintuple cryoapplication (30 s) over ciliary body. Samples of aqueous humor were collected 6, 12, 24 and 48 hours after albumin injection. pH, pO2, pCO2 values and HCO3- concentration were determined using Astrup microanalyser.


RESULTS
Parameters of aqueous humor, especially pH, pCO2 and HCO3- turned out to be fairly sensitive indicators reflecting the natural history of experimental uveitis. Cryotherapy characteristically modulates the pH, pCO2 and HCO3- values in the anterior chamber.


CONCLUSIONS
We came to the conclusion that monitoring of these parameters may give some important information about the intensity of the course of uveitis and the influence of the treatment. Normalisation of the values usually parallels clinical improvement.
Jedrzejewski
D
D
Katedry i l Kliniki Okulistycznej AM w Lublinie.
Raganowicz
J
J
Haszcz
D
D
Zarnowski
T
T
Sochocka
M
M
Chmiel
M
M
D000418:Albumins; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D001639:Bicarbonates / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism*; D017679:Cryotherapy; D010100:Oxygen / Q000378:metabolism*; D011817:Rabbits; D014605:Uveitis / Q000139:chemically induced / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy
D000418:Albumins; D001639:Bicarbonates; D002245:Carbon Dioxide; D010100:Oxygen
Zmiany w wartościach parametrów fizykochemicznych przemiany gazowej płynu komory przedniej oka królików w leczeniu doświadczalnie wywołanego zapalenia błony naczyniowej.