title: Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives.
abstract: A series of 2-substituted 3-chloro-1,4-naphthoquinones was synthesized, and the antiplatelet, antiinflammatory, and antiallergic activities of these compounds were evaluated. The structure-activity relationships in this series were also examined. Most of the 2-alkyl/arylcarboxamido derivatives of 3-chloro-1,4-naphthoquinone showed potent activities with similar trends in each of the activities evaluated.
authors.affiliation: Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan.
authors.forename: J C
authors.initials: JC
authors.lastname: Lien
authors.forename: L J
authors.initials: LJ
authors.lastname: Huang
authors.forename: J P
authors.initials: JP
authors.lastname: Wang
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: S C
authors.initials: SC
authors.lastname: Kuo
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D005966:Glucuronidase / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D009113:Muramidase / Q000378:metabolism; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009285:Naphthoquinones; D010975:Platelet Aggregation Inhibitors; D013481:Superoxides; D009113:Muramidase; D005966:Glucuronidase