title: Morphology of the inferior frontal gyrus in developmentally language-disordered adults.
abstract: The inferior frontal gyrus has traditionally been considered an important cortical region for language and may be important for understanding developmental language disorders. The morphology of the inferior frontal gyrus, as it appeared on T1-weighted sagittal magnetic resonance imaging (MRI) scans, was evaluated using a classification system that distinguished between seven basic morphological variants of the gyral and sulcal patterns in this region. This classification scheme was applied to the MRI scans of 41 neurologically normal adult subjects. To examine the relation between sulcal morphology and subject status, these subjects were sorted first by family history for developmental language disorders and then resorted by expression of behavioral signs consistent with a diagnosis of this disorder as determined by standardized testing. Morphological types that included an extra sulcus in the inferior frontal gyrus were statistically associated with the behaviorally based classification of subjects, but not with a positive family history for developmental language disorders. Because gyral patterns are prenatally determined, this finding is consistent with the theory that altered prenatal development contributes to the expression of a developmental language disorder.
authors.affiliation: Department of Speech and Hearing Sciences, University of Arizona, Tucson 85721, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Clark
authors.forename: E
authors.initials: E
authors.lastname: Plante
mesh_terms: D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007805:Language Development Disorders / Q000175:diagnosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010290:Parents