title: Valve repair versus replacement for mitral insufficiency: when is a mechanical valve still indicated?
abstract: OBJECTIVE
  Although many advantages of mitral valve reconstruction have been demonstrated, whether specific subgroups of patients exist in whom mechanical valve replacement offers advantages over mitral reconstruction remains undetermined.
  
  
  METHODS
  This study examined the late results of mitral valve surgery in patients with mitral insufficiency who received either a St. Jude Medical valve (n = 514) or a mitral valve reconstruction with ring annuloplasty (n = 725) between 1980 and 1996.
  
  
  RESULTS
  Overall operative mortality was 7.2% in the patients receiving a St. Jude Medical mitral valve and 5.4% in those undergoing mitral valve reconstruction (no significant difference); isolated mortality was 2.5% in the St. Jude Medical group and 2.2% in the valve reconstruction group (no significant difference). The follow-up interval was more than 5 years for 340 patients with a mean of 39.8 months (98.5% complete). Overall 8-year freedom from late cardiac death, reoperation, and all valve-related complications was 72.8% for the St. Jude Medical group and 64.8% for valve reconstruction group (no significant difference). For patients with isolated, nonrheumatic mitral valve disease, 8-year freedom from late cardiac death and reoperation was better in the mitral valve reconstruction group (88.3%) than in the St. Jude Medical valve group (86.0%; p = 0.05). Furthermore, Cox proportional hazards regression revealed that mitral valve reconstruction was independently associated with a lesser incidence of late cardiac death (p = 0.04), irrespective of preoperative New York Heart Association class. However, the St. Jude Medical valve offered better 8-year freedom from late cardiac death, reoperation, and all valve-related complications than did mitral valve reconstruction in patients with multiple valve disease (77.0% vs 45.3%; p < 0.01).
  
  
  CONCLUSIONS
  Therefore, mitral valve reconstruction appears to be the procedure of choice for isolated, nonrheumatic disease, whereas insertion of a St. Jude Medical valve should be preferred for patients with multiple valve disease.
authors.affiliation: Department of Surgery, New York University Medical Center, NY 10016, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Grossi
authors.forename: A C
authors.initials: AC
authors.lastname: Galloway
authors.forename: J S
authors.initials: JS
authors.lastname: Miller
authors.forename: G H
authors.initials: GH
authors.lastname: Ribakove
authors.forename: A T
authors.initials: AT
authors.lastname: Culliford
authors.forename: R
authors.initials: R
authors.lastname: Esposito
authors.forename: J
authors.initials: J
authors.lastname: Delianides
authors.forename: P M
authors.initials: PM
authors.lastname: Buttenheim
authors.forename: F G
authors.initials: FG
authors.lastname: Baumann
authors.forename: F C
authors.initials: FC
authors.lastname: Spencer
authors.forename: S B
authors.initials: SB
authors.lastname: Colvin
mesh_terms: D006348:Cardiac Surgical Procedures / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D016016:Proportional Hazards Models; D012086:Reoperation; D012214:Rheumatic Heart Disease / Q000150:complications; D016896:Treatment Outcome