Rotating samples in FT-RAMAN spectrometers.
It is customary to rotate samples in Raman spectroscopy to avoid absorption or sample heating. In FT-Raman experiments the rotation is always shown (typically 30-60 rpm) because higher speeds are thought to generate noise in the spectra. In this article we show that more rapid rotation is possible. A tablet containing maleic acid and one made up of sub-millimetre silica particles with metoprolol succinate as active ingredient were rotated at different speeds, up to 6760 rpm. The FT-Raman spectra were recorded and studied. We conclude that it is perfectly acceptable to rotate samples up to 1500 rpm.
De Paepe
A T
AT
Department of Chemistry, University of Southampton, UK.
Dyke
J M
JM
Hendra
P J
PJ
Langkilde
F W
FW
D000042:Absorption; D005583:Fourier Analysis; D006358:Hot Temperature; D008298:Maleates / Q000737:chemistry; D008790:Metoprolol / Q000737:chemistry; D012399:Rotation; D012822:Silicon Dioxide / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013607:Tablets
D008298:Maleates; D013607:Tablets; D012822:Silicon Dioxide; C030272:maleic acid; D008790:Metoprolol