Oligosaccharide Le(a)-Le(x): a cell surface marker for carcinomas derived from embryonic endoderm.
An immunohistochemical evaluation of Le(a)-Le(x) expression by adenocarcinomas of the biliary tree, pancreas, colon and stomach was undertaken as examples of epithelial tumors derived from embryonic endoderm. This complements previous studies showing that Lea-Lex was present on the cell surface of non-small cell lung carcinomas, some non-lung carcinomas, and is a prognostic marker for squamous cell lung carcinomas. All of the tumor specimen evaluated were positive and no expression of Le(a)-Le(x) was detected in derivatives of neural, connective or muscle tissues. These findings indicate that it could be informative to examine the biological significance of Le(a)-Le(x) not only in carcinogenesis but during embryogenesis, as well.
Stranahan
P L
PL
University of Colorado Cancer Center, Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
LaRoe
J
J
McCombs
R
R
Rahim
I
I
Kuhn
C W
CW
Pettijohn
D E
DE
D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology; D004622:Embryo, Mammalian; D004707:Endoderm; D005706:Gallbladder Neoplasms / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007413:Intestinal Mucosa / Q000473:pathology; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen; D008175:Lung Neoplasms / Q000473:pathology; D008679:Metaplasia; D018307:Neoplasms, Squamous Cell / Q000473:pathology; D009844:Oligosaccharides / Q000032:analysis*; D010190:Pancreatic Neoplasms / Q000473:pathology; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology
D014408:Biomarkers, Tumor; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen; D009844:Oligosaccharides; C111125:lewis(a)-lewis(x)