Higher risk of preeclampsia in the polycystic ovary syndrome. A case control study.
OBJECTIVE
To determine whether the risk of pregnancy-induced hypertensive disorders (PIHD) is higher in patients with the polycystic ovary syndrome (PCOS) than in non-PCOS controls, matched for age and parity.


METHODS
Retrospective analysis of eighty-one patients with PCOS, consecutively becoming pregnant during a seven-year period. Each PCOS-patient was matched for age and parity with one control patient. Chi-squared, Mann-Whitney or Fisher's exact-tests were used for statistical analysis.


RESULTS
Overall incidence of PIHD was similar in both study groups. However, incidence of preeclampsia was significantly higher in patients with PCOS than in controls (P = 0.02). This higher incidence can not be explained by body mass index, endocrine profile before pregnancy, induction of ovulation or treatment regimens.


CONCLUSIONS
PCOS-patients are at a significantly higher risk for preeclampsia than non-PCOS controls.
de Vries
M J
MJ
Department of Obstetrics and Gynaecology, Free University Hospital of Amsterdam, The Netherlands.
Dekker
G A
GA
Schoemaker
J
J
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D011388:Prolactin / Q000097:blood; D012189:Retrospective Studies; D012307:Risk Factors
D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone