title: c-myc, c-erb-B2, nm23 and p53 expression in human endometriosis.
abstract: We studied the expression of oncogenes and tumor-suppressor genes in human endometriosis in a retrospective pilot study. Sixteen patients with histologically verified pelvic endometriosis at the university-based tertiary care referral center were studied. Immunohistochemical determination of c-myc, c-erb-B2, nm23 and p53 expression in archival, paraffin-embedded pathological samples were used from patients operated upon for pelvic endometriosis. c-myc was expressed in 8/15 cases (53.3%). nm23 was expressed in 7/16 cases (43.7%). c-erb-B2 and p53 reactivity was undetectable in the samples studied. The c-myc oncogene and nm23 are overexpressed in many cases of endometriosis, and may play a still undefined role in its pathogenesis. Immuno-histochemistry is a useful tool for the study of oncogenic activation in this disease.
authors.affiliation: Hospital de Cruces, Departamento de Ginecologia, Baracaldo, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Schneider
authors.forename: E
authors.initials: E
authors.lastname: Jimenez
authors.forename: F
authors.initials: F
authors.lastname: Rodriguez
authors.forename: J G
authors.initials: JG
authors.lastname: del Tanago
mesh_terms: D001706:Biopsy; D004715:Endometriosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D016147:Genes, Tumor Suppressor; D018734:Genes, erbB-2; D016259:Genes, myc; D016158:Genes, p53; D006801:Humans; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis* / Q000096:biosynthesis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis* / Q000096:biosynthesis; D014157:Transcription Factors / Q000032:analysis* / Q000096:biosynthesis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis; D014591:Uterine Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D016271:Proto-Oncogene Proteins c-myc; D018719:Erb-b2 Receptor Tyrosine Kinases; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; C517938:NME1 protein, human