Anticardiolipin antibodies in pre-eclampsia and intrauterine growth retardation.
OBJECTIVE
To establish an association of anticardiolipin antibody (ACA) levels and pre-eclampsia or intrauterine growth retardation (IUGR).


METHODS
Twenty-eight patients with pre-eclampsia, 28 with IUGR and 28 normotensive control group were matched for maternal age, race, weight, cigarette smoking, and parity. All had plasma anticardiolipin antibodies (GPL and MPL) detected by the modified enzyme-linked immuno-absorbent assay (ELISA) technique.


RESULTS
No statistical significant difference in ACA values, both GPL and MPL, was found among the three groups studied Furthermore, none reached a value of ACA that could be considered clinically relevant (> 15).


CONCLUSIONS
No association was found in anticardiolipin antibody levels between pre-eclamptic and IUGR versus the control group.
D'Anna
R
R
Institute of Gynecology, University of Messina, Italy.
Scilipoti
A
A
Leonardi
J
J
Scuderi
M
M
Jasonni
V M
VM
Leonardi
R
R
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood* / Q000276:immunology; D015331:Cohort Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D011225:Pre-Eclampsia / Q000097:blood / Q000276:immunology*; D011247:Pregnancy / Q000097:blood / Q000276:immunology*; D011446:Prospective Studies; D012016:Reference Values
D017153:Antibodies, Anticardiolipin; D007074:Immunoglobulin G; D007075:Immunoglobulin M