title: Arrhythmia curve interpretation using a dynamic system model of the myocardial pacemaker.
abstract: A problem of identifying the phase response curve of the myocardial pacemaker was investigated using a simple dynamic system model of cardiac arrhythmia. A hybrid optimization method of a genetic algorithm and a local optimization technique was employed to obtain a solution of the model fitting. The method was applied to two categories of arrhythmias, ventricular parasystole and high-degree AV block. The present study offered a new insight into the mechanism of cardiac arrhythmias.
authors.affiliation: School of Allied Health Sciences, Kitasato University, Kanagawa, Japan. ikeda@kitasato-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Takayanagi
authors.forename: A
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Nara
authors.forename: H
authors.initials: H
authors.lastname: Miyahara
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D003198:Computer Simulation; D004562:Electrocardiography; D006327:Heart Block / Q000503:physiopathology; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D017574:Parasystole / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted