title: Chromium picolinate supplementation for diabetes mellitus.
abstract: Chromium picolinate is a widely available nutritional supplement marketed for a plethora of afflictions. There is some evidence, including results from human studies, that it has a role in glucose homeostasis. We report the case of a 28-year-old woman with an 18-year history of type 1 diabetes mellitus whose glycosylated hemoglobin (Hb A1c) declined from 11.3% to 7.9% 3 months after initiation of chromium picolinate, 200 micrograms 3 times daily. Chromium picolinate continues to fall squarely within the scope of "alternative medicine," with both unproven benefits and unknown risks. It deserves closer scrutiny with additional prospective, randomized, double-blind, placebo-controlled trials to evaluate its efficacy in improving outcomes in patients with diabetes. A brief review of the literature was done to assist physicians who are being called upon to counsel and treat patients who are engaging in alternative therapies.
authors.affiliation: Mercy Health System-Northern Region Family Practice Residency, Toledo, Ohio 43624, USA. foxgary@aol.com
authors.forename: G N
authors.initials: GN
authors.lastname: Fox
authors.forename: Z
authors.initials: Z
authors.lastname: Sabovic
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D000529:Complementary Therapies; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D010848:Picolinic Acids / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D010848:Picolinic Acids; D005947:Glucose; C030614:picolinic acid