Sibling aggregation of low- and high-density lipoprotein cholesterol and apolipoproteins B and A-I levels in black and white children: the Bogalusa Heart Study.
OBJECTIVE
To examine sibling aggregation of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (apo) B and apo A-I in white versus black school-aged children.


METHODS
Study subjects included 790 full sibships representing 1305 sibpairs aged 5 to 17 years from a biracial community.


METHODS
Intraclass correlation coefficients estimated by analyses of covariance were used to examine sibling aggregation of LDL-C, HDL-C, apo B and apo A-I. The influences of obesity and other lifestyle variables on sibpair differences in LDL-C, HDL-C, apo B and apo A-I were evaluated in black and white children by stepwise multiple regression analyses.


RESULTS
Intraclass correlation coefficients for LDL-C and apo B in black children were lower than those in white children (0.17 and 0.11 versus 0.32 and 0.33, respectively, P < 0.05-0.01); no racial difference was found for HDL-C and apo A-I. Intraclass correlation coefficients for LDL-C and HDL-C were similar to that of apo B and apo A-I, respectively and the sibpair differences in LDL-C and HDL-C were correlated with those of apo B and apo A-I, respectively (P < 0.01). Obesity exerted a greater effect on sibpair differences in LDL-C, HDL-C and apo B in black children than in white children.


CONCLUSIONS
These results suggest that the hereditary influence on LDL-C and apo B is more important in white children than in black children, especially for apo B. Further, genetic influence on LDL-C versus apo B, or HDL-C versus apo A-I may be similar.
Chen
W
W
Tulane Center for Cardiovascular Health, School of Public Health & Tropical Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112-2824, USA.
Srinivasan
S R
SR
Bao
W
W
Wattigney
W A
WA
Berenson
G S
GS
D000293:Adolescent; D017677:Age Distribution; D016632:Apolipoprotein A-I / Q000032:analysis / Q000235:genetics*; D001055:Apolipoproteins B / Q000032:analysis / Q000235:genetics*; D044383:Black People; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000032:analysis / Q000235:genetics*; D008078:Cholesterol, LDL / Q000032:analysis / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D008145:Louisiana / Q000453:epidemiology; D008297:Male; D015999:Multivariate Analysis; D009679:Nuclear Family / Q000208:ethnology*; D012042:Registries; D012044:Regression Analysis; D017678:Sex Distribution; D044465:White People; D001741:Black or African American
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL