Ca-release channels (ryanodine receptors) of sarcoplasmic reticulum: structure and properties. A review.
Recent data on characteristics of the structure, function, and regulation of sarcoplasmic reticulum Ca-release channels (ryanodine receptors) from various types of muscles are summarized. The history of identification and purification of Ca-release channels, the properties of isoforms expressed in various tissues, their electric characteristics, and regulation by endogenous and exogenous compounds are described. The phosphorylation of Ca-release channels by protein kinases and their interaction with various intracellular regulatory proteins are discussed. The proposed mechanisms of excitation-contraction coupling and the role of the Ca-release channels in this process are analyzed.
Rubtsov
A M
AM
Department of Biochemistry, School of Biology, Lomonosov Moscow State University, Russia. amr@atpase.bio.msu.su
Batrukova
M A
MA
D000818:Animals; D006801:Humans; D008958:Models, Molecular; D009119:Muscle Contraction / Q000502:physiology; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000737:chemistry / Q000502:physiology*
D019837:Ryanodine Receptor Calcium Release Channel