title: Enterococcus faecalis localization in experimental endophthalmitis: role of plasmid-encoded aggregation substance.
abstract: Enterococci have emerged as leading agents of nosocomial infection, yet relatively little is known about the pathogenesis of enterococcal disease. In previous studies, we developed an Enterococcus faecalis endophthalmitis infection model which provides unique opportunities to study the evolution of enterococcal disease by direct observation, as well as through sensitive electrophysiologic measures of organ function. The present study was designed to determine whether E. faecalis possesses traits that permit its attachment to mammalian tissues during infection. It was also of interest to determine whether a plasmid-encoded adhesin, aggregation substance, contributes to enterococcal localization or otherwise mediates adherence to alternate sites. These studies found that, in this model, enterococci attach to membranous structures occurring within the vitreous but that this attachment or the course or severity of disease is unaffected by the aggregation substance phenotype.
authors.affiliation: Department of Ophthalmology, Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA. brad-jett@ouhsc.edu
authors.forename: B D
authors.initials: BD
authors.lastname: Jett
authors.forename: R V
authors.initials: RV
authors.lastname: Atkuri
authors.forename: M S
authors.initials: MS
authors.lastname: Gilmore
mesh_terms: D018829:Adhesins, Bacterial / Q000502:physiology*; D000818:Animals; D001422:Bacterial Adhesion; D009877:Endophthalmitis / Q000382:microbiology*; D013293:Enterococcus faecalis / Q000502:physiology*; D010957:Plasmids; D011817:Rabbits; D014774:Virulence
chemical_list: D018829:Adhesins, Bacterial