title: [Role of Laboratory of Biochemistry, Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences in the evolution of views of tuberculosis pathogenesis and in the development of up-to-date approaches to its treatment].
abstract: The stages of the researches made by the Laboratory of Biochemistry, Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences, were considered. They were divided into three periods. In the first (prewar) period it was found that the specific features of the course of tuberculosis were closely associated with metabolic and neuroendocrine regulatory changes. Based on these researches, a hygienic and dietary regimen was developed for patients with tuberculosis. The second stage refers to the advent of antibiotics. At the same time the pharmacodynamics of drugs and some other chemicals was investigated and their side effects found. Criteria for early laboratory diagnosis of adverse reactions and methods of their metabolic correction were elaborated. The homeostatic changes accompanying the bulky phthisiolosurgical interventions were studied. The third (present-day) stage of studies is associated with progress in basic science. The main line of investigations is to study the systems of humoral regulation and metabolism of the cells responsible for the development and evolution of a tuberculous process.
authors.affiliation: Central NII of Tuberculosis RAMN, Moscow.
authors.forename: G O
authors.initials: GO
authors.lastname: Kaminskaia
mesh_terms: D000047:Academies and Institutes; D000818:Animals; D001671:Biochemistry / Q000379:methods*; D006801:Humans; D007753:Laboratories; D009031:Moscow; D014376:Tuberculosis / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism
vernacular_title: Rol' Laboratorii Biokhimii TsNIIT RAMN v evoliutsii predstavlenií o patogeneze tuberkuleza i formirovanii sovremennykh podkhodov k ego lecheniiu.