title: Circulating levels of soluble intercellular adhesion molecule-1 in non-small cell lung cancer patients.
abstract: Intercellular adhesion molecule-1 has been implicated in tumor progression and metastasis. Like soluble forms of other membrane receptors, a circulating form of intercellular adhesion molecule-1 (sICAM-1) has been identified in the serum of healthy subjects and it has been found in malignant diseases at increased levels. This study evaluated the serum concentration of sICAM-1 in 112 patients with non-small cell lung cancer (NSCLC). Soluble ICAM-1 levels were significantly higher in all patients when compared with the controls; serum concentration of sICAM-1 correlated with clinical stage and tumor progression. These results suggest that elevated levels of serum ICAM-1 could be of prognostic importance in patients with NSCLC.
authors.affiliation: Cattedra di Oncologia Medica, Dipartimento di Internistica Clinica e Sperimentale, II Universita di Napoli, c/o II Policlinico, III Padiglione, via S. Pansini 5, Napoli, 80131, Italy.
authors.forename: F
authors.initials: F
authors.lastname: De Vita
authors.forename: S
authors.initials: S
authors.lastname: Infusino
authors.forename: A
authors.initials: A
authors.lastname: Auriemma
authors.forename: M
authors.initials: M
authors.lastname: Orditura
authors.forename: G
authors.initials: G
authors.lastname: Catalano
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000473:pathology / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D018799:Intercellular Adhesion Molecule-1; D005047:Etoposide; D002945:Cisplatin