Inhibitory effect of soybean hypocotyls on Epstein-Barr virus early antigen induction and skin tumor promotion.
The in vitro anti-tumor promoting effect of hypocotyls from fresh soybeans was evaluated. The dimethyl sulfoxide extracts of hypocotyls showed a stronger inhibitory effect than that of soybeans on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate. Daidzin, an isoflavone with the highest content of hypocotyls, was also inhibitory. An in vivo evaluation of anti-tumor promoting activity of hypocotyls against the skin of mice also revealed a significant inhibitory effect on tumor formation.
Zaizen
Y
Y
Department of Biochemistry, Oita Medical University, Japan.
Tokuda
H
H
Nishino
H
H
Takeshita
M
M
D000818:Animals; D000956:Antigens, Viral / Q000378:metabolism*; D002051:Burkitt Lymphoma / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D018546:Hypocotyl / Q000502:physiology*; D007529:Isoflavones / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013025:Glycine max / Q000737:chemistry / Q000502:physiology*; D013755:Tetradecanoylphorbol Acetate; D014407:Tumor Cells, Cultured
D000956:Antigens, Viral; D004791:Enzyme Inhibitors; C033305:Epstein-Barr virus early antigen; D007529:Isoflavones; C013908:daidzin; D013755:Tetradecanoylphorbol Acetate