[A comparative genetic analysis of the role of the brain dopaminergic systems in the regulation of behavioral elements in the "open field" test in DBA/2J and C57BL/6J mice].
The effects of intraperitoneal injections of sulpiride (10 mg/kg), bromocriptine (5 mg/kg), and alaptide (1 mg/kg) on the behavior of male C57BL/6J (C57BL) and DBA/2J (DBA) mice in the open-field test were studied. In this test, C57BL mice exhibited a significantly higher horizontal locomotor activity than DBA mice, whereas DBA mice moved in place substantially longer than C57BL mice. Dopaminergic agents had different effects on the open-field behavior in different mouse strains. Alaptide increased horizontal locomotor activity in DBA, but not in C57BL mice; all the three agents decreased the duration of movement in place in DBA but not in C57BL mice; bromocriptine suppressed vertical locomotor activity and the act of looking into holes in C57BL but not in DBA mice. Thus, interstrain differences in dopaminergic functions were demonstrated. The revealed strain-specific characteristics largely contribute to the determination of open-field behavior in the studied mouse strains.
Kuligina
E Sh
ESh
Department of Genetics and Breeding, St. Petersburg State University, Russia.
Lebedev
A A
AA
Luchnikova
E M
EM
D000818:Animals; D001921:Brain / Q000187:drug effects*; D001971:Bromocriptine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009479:Neuropeptides / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000494:pharmacology; D013469:Sulpiride / Q000494:pharmacology
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D009479:Neuropeptides; D010456:Peptides, Cyclic; D001971:Bromocriptine; D013469:Sulpiride; C049178:cyclo(alanine-(1-amino-1-cyclopentane)carbonyl); D004298:Dopamine
Sravnitel'no-geneticheskiĭ analiz roli dofaminergicheskikh sistem mozga v kontrole élementov povedeniia v teste "otkrytoe pole" u mysheĭ DBA/2J i C57BL/6J.