Platelet-derived growth factor reverses the effects induced by NSAIDs on ulcer healing.
BACKGROUND
It is known that non-steroidal anti-inflammatory drug (NSAID) use delays the healing of peptic ulcers and that growth factors play an important role in the ulcer healing process.


OBJECTIVE
To evaluate the effect of platelet-derived growth factor (PDGF) in healing chronic gastric ulcers in rats treated with NSAIDs.


METHODS
Chronic gastric ulcers were induced with acetic acid in male Wistar rats and then treated with either aspirin (100 mg/kg/day), indomethacin (2 mg/kg/day), PDGF-BB (0.1 nM/kg/day) or combinations. Gastric secretion and ulcer size, wound contraction, mucosal regeneration and cell proliferation were assessed in histological specimens.


RESULTS
Both aspirin and indomethacin delayed the healing rate of gastric ulcers and reduced ulcer contraction, mucosal regeneration and cell proliferation. All these effects were completely reversed by oral treatment with PDGF-BB without affecting gastric acid secretion.


CONCLUSIONS
Oral administration of PDGF accelerates ulcer healing and reverses the effects induced by NSAIDs on ulcer healing without affecting gastric secretion.
Arceiz
E
E
Service of Pathology, Hospital Clínco Universitario, Colegio Universitario de Huesca, Zaragoza, Spain.
Lanas
A
A
Ortego
J
J
Sáinz
R
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D006097:Granulation Tissue / Q000187:drug effects / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010982:Platelet-Derived Growth Factor; D001241:Aspirin; D007213:Indomethacin