Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage.
The alpha7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity administered 24 h before, but not concomitantly with, NMDA. This action was blocked by nicotinic but not muscarinic antagonists. DMXB (1 mg/kg i.p.) also reduced infarct size in rats when injected 24 h before, but not during, focal ischemic insults. In a mecamylamine-sensitive manner, alpha7 receptors appear neuroprotective in non-apoptotic model.
Shimohama
S
S
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Greenwald
D L
DL
Shafron
D H
DH
Akaika
A
A
Maeda
T
T
Kaneko
S
S
Kimura
J
J
Simpkins
C E
CE
Day
A L
AL
Meyer
E M
EM
D000818:Animals; D001597:Benzylidene Compounds / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011978:Receptors, Nicotinic / Q000502:physiology*
D001597:Benzylidene Compounds; D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D018722:Nicotinic Agonists; D011725:Pyridines; D011978:Receptors, Nicotinic; C088936:3-(2,4-dimethoxybenzylidene)anabaseine