Effects of cholecystokinin-B receptor antagonist on dopamine system in tenascin mutant mice.
The aim of this study was to investigate the effect of cholecystokinin (CCK) receptor antagonist on the abnormal behavior and dopamine (DA) transmission of tenascin (TN)-gene knockout mice. Recently, we demonstrated that TN-gene deficient mice show hyperlocomotion that is related to reduced DA transmission and tyrosine hydroxylase (TH) activities in the brain. In this report, we show that the intraperitoneal administration of a CCK-B receptor antagonist, PD135158 (0.1 mg/kg), but not a CCK-A receptor antagonist, lorglumide, inhibited hyperlocomotion. Moreover, PD135158 reversed the low levels of DA turnover rate and TH activities in the striatum of TN-gene knockout mouse brain. These results suggest that CCK-B receptor is involved in the behavior of TN-gene knockout mouse through striatal DA transmission.
Fukamauchi
F
F
Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, Japan.
Wang
Y J
YJ
Mataga
N
N
Kusakabe
M
M
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D006948:Hyperkinesis / Q000235:genetics; D007211:Indoles / Q000494:pharmacology*; D008536:Meglumine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D009435:Synaptic Transmission / Q000187:drug effects*; D019063:Tenascin / Q000633:toxicity*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D007211:Indoles; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; D019063:Tenascin; D015102:3,4-Dihydroxyphenylacetic Acid; C065600:PD 135158; D008536:Meglumine; D014446:Tyrosine 3-Monooxygenase; D011377:Proglumide; C048181:lorglumide; D004298:Dopamine