Role of nitric oxide in transmission of dengue virus specific suppressor signal.
Production of NO2- was maximum when peritoneal M phi was incubated with SF (40 mg) for 45 min. Pretreatment of M phi with anti-SF-antisera inhibited production of NO2- Pretreatment of M phi with NG monomethyl L-arginine (L-NMA) or arginase, an inhibitor of L-arginine dependent pathway, inhibited production of NO2- and transmission of suppressor signal in a dose-dependent manner. This indicates that NO and Ca2+ serve as intracellular signal in transmission of DV-induced suppressor signal.
Khare
M
M
Postgraduate Department of Microbiology, KG Medical College, Lucknow, India.
Chaturvedi
U C
UC
D000818:Animals; D003716:Dengue Virus / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000276:immunology*; D051379:Mice; D009569:Nitric Oxide / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D009569:Nitric Oxide