Vertical transmission of hepatitis C virus infection: usefulness of viremia detection in HIV-seronegative hepatitis C virus-seropositive mothers.
Seventy mother-newborn pairs were studied for hepatitis C viremia to evaluate the risk of vertical transmission of hepatitis C virus from human immunodeficiency virus-negative mothers. Forty-five mothers were hepatitis C virus-RNA positive: 4 to 45 children were positive at birth and during follow-up. The level of viremia plays an important role in vertical transmission.
Giacchino
R
R
Department of Infectious Diseases G. Gaslini Children's Hospital, Genoa, Italy.
Tasso
L
L
Timitilli
A
A
Castagnola
E
E
Cristina
E
E
Sinelli
N
N
Gotta
C
C
Giambartolomei
G
G
Moscatelli
P
P
Picciotto
A
A
D005260:Female; D018023:HIV Seronegativity; D016174:Hepacivirus / Q000302:isolation & purification*; D006526:Hepatitis C / Q000151:congenital* / Q000175:diagnosis / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D012367:RNA, Viral / Q000097:blood; D014766:Viremia / Q000175:diagnosis
D012367:RNA, Viral