[Comparative study of permeability of derivatives of gamma-aminobutyric and gamma-hydroxybutyric acids through hemato-encephalic barrier].
The authors studied the permeability of the blood-brain barrier (CEB) to two nootropics: calcium ketogomopantothenate (KRA-Ca), a GABA derivative, and and calcium salt of oxybutyrate (OB-Ca), a derivative of GOBA. It was established that both preparations penetrate the CEB easily and are found in the brain at different intervals after their administration. However, essential differences in the distribution constant of these drugs were disclosed: KPA-Ca permeated the CEB more intensively and was accumulated in larger amounts in the late-term intervals.
Nasybullina
N M
NM
Institute of Pharmacology, Moscow, Russia.
Zherdev
V P
VP
Gunar
V I
VI
Kopelevich
V M
VM
Kozlova
G S
GS
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D018697:Nootropic Agents / Q000493:pharmacokinetics*; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar; D012978:Sodium Oxybate / Q000493:pharmacokinetics*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
C110740:N-(4-hydroxy-3,3-dimethyl-2-oxo-1-butyryl)-gamma-aminobutyric acid; D018697:Nootropic Agents; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate
Sravnitel'noe izuchenie pronitsaemosti cherez gematoéntsefalicheskiĭ bar'ier preparatov proizvodnykh g-aminomaslianoĭ i g-oksimaslianoĭ kislot.