title: A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages.
abstract: OBJECTIVE
  To evaluate the medical relevance of hyperhomocysteinemia in women with primary recurrent miscarriages.
  
  
  METHODS
  Case report and retrospective cross-sectional study.
  
  
  METHODS
  Hematology outpatient department of a university hospital.
  
  
  METHODS
  Case report concerning a woman with five consecutive fetal losses. One hundred consecutive women with primary recurrent unexplained miscarriages (study group) and matched healthy controls (control group) with no antecedent fetal loss.
  
  
  METHODS
  Venous blood sample collection in resting individuals.
  
  
  METHODS
  Plasma total homocysteine concentrations, plasma folate concentrations, and DNA analysis for the C677T mutation of the 5,10 methylene tetrahydrofolate reductase gene. Normal threshold homocysteine concentration was obtained from values found in the control group (95th percentile).
  
  
  RESULTS
  The case patient was hyperhomocysteinemic, was homozygous for the C677T mutation in the methylene tetrahydrofolate reductase gene, and had plasma folate deficiency. Folic acid and pyridoxine administration normalized the homocysteine concentration and favored a successful pregnancy. In the retrospective study, 12 of 100 patients were hyperhomocysteinemic. Twenty percent had the C677T methylene tetrahydrofolate reductase genotype and 15% had low plasma folate concentrations. The highest values of homocysteine concentration were found in patients with both the C677T genotype and folate deficiency.
  
  
  CONCLUSIONS
  Hyperhomocysteinemia should be identified in women with recurrent miscarriages because therapeutic normalization might permit a normal birth.
authors.affiliation: Service de Médecine B--Médecine vasculaire, Hôpital Saint Eloi, Montpellier, France.
authors.forename: I
authors.initials: I
authors.lastname: Quere
authors.forename: H
authors.initials: H
authors.lastname: Bellet
authors.forename: M
authors.initials: M
authors.lastname: Hoffet
authors.forename: C
authors.initials: C
authors.lastname: Janbon
authors.forename: P
authors.initials: P
authors.lastname: Mares
authors.forename: J C
authors.initials: JC
authors.lastname: Gris
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000188:drug therapy; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009154:Mutation; D009994:Osmolar Concentration; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D011736:Pyridoxine / Q000627:therapeutic use; D012016:Reference Values; D012189:Retrospective Studies
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D011736:Pyridoxine