Regulated release of serotonin from axonal growth cones isolated from the fetal rat brain.
In the present work we propose an hypothetical model related to a molecular recognizing system for serotonin in isolated growth cone particles. This model is supported by previous results from our laboratory plus new ones which show that growth cones release serotonin tonically and such release can be stimulated by potassium in a calcium-dependent manner. The present results, together with other author's data, suggest a physiological basis for the putative role of serotonin as a trophic factor during nervous system development.
Mercado
R
R
Department of Physiology, Biophysics and Neurosciences, Centro de Investigación y de Estudios Avanzados del IPN, México, D.F., México.
Floran
B
B
Hernandez
J
J
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure*; D001921:Brain / Q000196:embryology* / Q000648:ultrastructure*; D002118:Calcium / Q000494:pharmacology; D005865:Gestational Age; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D011188:Potassium; D002118:Calcium