Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden).
Bilateral renal vein thrombosis and venous sinus thrombosis were diagnosed within 3 weeks of birth in a full-term neonate. Heterozygosity for a factor V mutation leading to resistance against the anticoagulatory properties of activated protein C was found. Heparin therapy led to resolution of the thrombotic manifestations. With long-term oral anticoagulation, no relapse or other thrombotic event occurred during infancy.
Pohl
M
M
University Children's Hospital, Albert-Ludwig University, Freiburg, Germany.
Zimmerhackl
L B
LB
Heinen
F
F
Sutor
A H
AH
Schneppenheim
R
R
Brandis
M
M
D000925:Anticoagulants / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D006493:Heparin / Q000627:therapeutic use; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D002542:Intracranial Embolism and Thrombosis / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D009154:Mutation; D012082:Renal Veins; D013927:Thrombosis / Q000150:complications / Q000188:drug therapy / Q000235:genetics*
D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V; D006493:Heparin