Enantioselectivity in chiral capillary electrophoresis with polysaccharides.
This review surveys enantiomer separation by capillary electrophoresis (CE) using polysaccharides as chiral selectors. Many ionic or electrically neutral polysaccharides, such as heparin, chondroitin sulfate, dextrin, etc., have been employed successfully for the CE separation of enantiomers. The operational conditions that affect the enantioselectivity of the chiral separation system will be described. The mechanism of enantioseparation will also be discussed briefly.
Nishi
H
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Analytical Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
D003505:Cyclodextrins / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D009994:Osmolar Concentration; D011108:Polymers / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification*; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D013499:Surface Properties
D003505:Cyclodextrins; D011108:Polymers; D011134:Polysaccharides