Magna-field irradiation: work in progress in bone marrow transplantation at The Princess Margaret Hospital, Toronto.
Our work with total body irradiation (TBI) for acute leukemia in relapse dates from 1959. Following reports of the Seattle experience, we treated a small number of patients in remission--lowering the dose to 500 rad given at 50 rad/min, based in part on our experience with radiation pneumonitis complicating upper HBI. We have treated 51 patients since July 1979, with an actuarial survival of 65% overall, and 85% for patients 35 years-old or less. A specially designed cobalt-60 unit is used, which allows very large fields and high exposure rates. Dose is calculated at midplane and a homogeneity of +/- 5% obtained.
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The Princess Margaret Hospital, Toronto, Ontario, Canada.
Messner
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D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D017619:Hemibody Irradiation; D006801:Humans; D007938:Leukemia / Q000000981:diagnostic imaging* / Q000628:therapy; D009864:Ontario; D017564:Radiation Pneumonitis / Q000209:etiology; D011859:Radiography; D011879:Radiotherapy Dosage; D012008:Recurrence; D016896:Treatment Outcome; D014916:Whole-Body Irradiation / Q000379:methods*