title: [Anesthesia unrelated triggering of a fatal malignant hyperthermia crisis].
abstract: For incidents of malignant hyperthermia (MH) outside the hospital, a high number of unrecorded cases must be reckoned with because of an insufficient knowledge of emergency services and poor identification and documentation that make it impossible to classify acute situations under the diagnosis of malignant hyperthermia crisis. As a result, there are no statistical data in this field, and only case reports with a broad spectrum of suspected trigger mechanisms have been published. The case described in this report is a proved example of a non-anesthesia-related triggering of MH in a 21-year-old man who had had an anesthetic-induced MH manifestation in childhood, which was confirmed with an in vitro contracture test. After visiting a restaurant, he became unconscious and convulsive after consuming a high level of alcohol (2.9/1000). The first cardiocirculatory arrest occurred directly before hospitalization. After admission, the patient showed a full-blown MH episode whose subsequent fatality was unavoidable in spite of adapted and optimal therapy. Suspected trigger mechanisms seem to be multifactoral (excessive alcohol consumption, over-heating, mental stress) as a forensic investigation did not point to any particular signs of typical trigger substances. The case demonstrates again that an MH attack might be triggered under certain non-anaesthesia-related situations. For patients with an MH disposition, additional information on their behavior outside the hospital is required.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und Intensivtherapie der Universität Leipzig.
authors.forename: D
authors.initials: D
authors.lastname: Olthoff
authors.forename: C
authors.initials: C
authors.lastname: Vonderlind
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000768:Anesthesia, General; D017809:Fatal Outcome; D006323:Heart Arrest; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology / Q000503:physiopathology*
vernacular_title: Anästhesie-unabhängige Auslösung einer tödlichen Maligne Hyperthermie-Krise.