[Modulation of uterine contractile activity by steroid sex hormones. Review].
Sexual steroids play an important role in the regulation of contractile uterine activity. Progesterone has shown a relaxant effect on rabbit, rat and human uterus. In addition it has been reported that 5 beta-reduced metabolites are more potent than their precursor in the rat uterus. In the regard to their mechanism of action it is known they act by means of a non-genomic mechanism and it has not been identified a some data suggest steroids inhibit calcium influx to muscular cell by blockade of voltage- and/or receptor- operated channels. Regulation of uterine contractility by steroid hormones during sexual cycle and pregnancy suggest an important physiologic role by inducing a quiescent state necessary for maintaining of pregnancy.
Juárez-Bengoa
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A
Instituto de Investigaciones Biomédicas, UNAM.
Perusquía
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M
D000109:Acetylcholine / Q000494:pharmacology; D000728:Androgens / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism / Q000494:pharmacology; D011372:Progestins / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013739:Testosterone / Q000378:metabolism / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology
D000728:Androgens; D012739:Gonadal Steroid Hormones; D011372:Progestins; D012701:Serotonin; D013739:Testosterone; D011374:Progesterone; D010121:Oxytocin; D000109:Acetylcholine
Modulación de la actividad contráctil uterina por hormonas esteroides sexuales. Revisión.