Enrichment for loci identical-by-descent between pairs of mouse or human genomes by genomic mismatch scanning.
Mapping genes that underlie complex genetic traits, including genes that determine susceptibility to common diseases, requires an efficient method for high-resolution genotyping. Single-nucleotide differences between pairs of allelic sequences from unrelated individuals occur approximately once in every kilobase. Genomic mismatch scanning (GMS), by analyzing numerous single-nucleotide polymorphisms in a single genome-wide step, offers a potentially powerful and efficient approach to linkage analysis. GMS, originally developed in a yeast system, is shown here to be applicable to the more complex mouse and human genomes.
McAllister
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Division of Cardiovascular Medicine, Stanford University Medical Center, California 94305-5307, USA.
Penland
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Brown
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D000251:Adenosine Triphosphatases; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods*; D003433:Crosses, Genetic; D029968:Escherichia coli Proteins; D005260:Female; D005821:Genetic Techniques; D015894:Genome, Human; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018895:Microsatellite Repeats; D000070956:MutL Proteins; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C074770:MutL protein, E coli; D000251:Adenosine Triphosphatases; D000070956:MutL Proteins