title: Osteoradionecrosis of the jaws as a risk factor in radiotherapy: a report of an eight-year retrospective review.
abstract: Osteoradionecrosis of the jaws is a severe complication of radiotherapy in the treatment of the head and neck neoplasms. The literature indicates a recent decline in the reported incidence of this complication. The purpose of this study was to further assess the incidence rate for osteoradionecrosis. Factors previously associated with an increased risk for osteoradionecrosis were evaluated to determine possible relationships. A retrospective chart review was conducted for 193 patients treated with radiotherapy for malignant head and neck tumors over an eight-year period. Recorded diagnoses of osteoradionecrosis were noted. Factors previously correlated with the development of osteoradionecrosis were assessed. Of the 193 charts reviewed, 9 diagnoses of osteoradionecrosis of the jaws were made representing an incidence rate of 4.7% for the period evaluated. No single factor was noted to be associated with the development of osteoradionecrosis. The results indicate a low incidence rate for osteoradionecrosis as a post-radiation treatment complication. No single causative factor could be identified suggesting a multifactorial interaction responsible for osteoradionecrosis.
authors.affiliation: The University of Chicago, MC-2108, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Toljanic
authors.forename: M
authors.initials: M
authors.lastname: Ali
authors.forename: D J
authors.initials: DJ
authors.lastname: Haraf
authors.forename: E E
authors.initials: EE
authors.lastname: Vokes
authors.forename: W J
authors.initials: WJ
authors.lastname: Moran
authors.forename: L
authors.initials: L
authors.lastname: Graham
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002641:Chicago / Q000453:epidemiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D007571:Jaw Diseases / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010025:Osteoradionecrosis / Q000453:epidemiology / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors