Adoptively transferred EAE in gamma delta T cell-knockout mice.
Recently there has been evidence suggesting that gamma delta receptor-bearing T cells may play a role in both multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). We have recently described approaches for the generation of encephalitogenic T-cell populations from EAE-resistant strains of mice. Using encephalitogenic T-cell lines and clones generated from wild-type C57BL/6 mice we have studied adoptively transferred EAE in C57BL/6-TCR delta-knockout mice. We now report that the adoptive transfer of encephalitogenic T cells into TCR delta T-knockout mice leads to clinical EAE that is not significantly different in severity or time course than that seen after transfer into wild-type C57BL/6 mice. We conclude that gamma delta T cells do not play an integral role in the mediation or regulation of the effector-phase mechanisms in EAE.
Clark
R B
RB
Department of Medicine, Division of Rheumatic Diseases, University of Connecticut Medical School, Farmington 06032, USA.
Lingenheld
E G
EG
D019264:Adoptive Transfer / Q000379:methods; D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006321:Heart; D007267:Injections; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D004676:Myelin Basic Protein / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics*; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation
D004676:Myelin Basic Protein; D016692:Receptors, Antigen, T-Cell, gamma-delta