title: Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, Connecticut 06340, USA.
authors.forename: E F
authors.initials: EF
authors.lastname: Kleinman
authors.forename: E
authors.initials: E
authors.lastname: Campbell
authors.forename: L A
authors.initials: LA
authors.lastname: Giordano
authors.forename: V L
authors.initials: VL
authors.lastname: Cohan
authors.forename: T H
authors.initials: TH
authors.lastname: Jenkinson
authors.forename: J B
authors.initials: JB
authors.lastname: Cheng
authors.forename: J T
authors.initials: JT
authors.lastname: Shirley
authors.forename: E R
authors.initials: ER
authors.lastname: Pettipher
authors.forename: E D
authors.initials: ED
authors.lastname: Salter
authors.forename: T A
authors.initials: TA
authors.lastname: Hibbs
authors.forename: F M
authors.initials: FM
authors.lastname: DiCapua
authors.forename: J
authors.initials: J
authors.lastname: Bordner
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D001665:Binding Sites; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006877:Hydroxamic Acids / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000737:chemistry* / Q000494:pharmacology*; D020889:Rolipram; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D006877:Hydroxamic Acids; D010726:Phosphodiesterase Inhibitors; D011760:Pyrrolidinones; D014409:Tumor Necrosis Factor-alpha; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram