[Human herpesvirus-6 and -7 infection and bone marrow transplantation (BMT)].
In our all patients, the antibodies to HHV-6 and -7 were positive before BMT. HHV -6 and -7 DNA were sometimes detected after BMT, and HHV-6 infection after BMT caused fever, interstitial peumonitis, diarrhea, and myelosuppression. However, HHV -7 didn't induce any clinical symptoms. For the diagnosis of the HHV-6 or -7 infection, we used the virus isolation, semiquantitative PCR, and 4-hold elevation of the antibodies to HHV-6 or -7. Ganciclovir, foscarnet, high dose gamma-globulin and high dose acyclovir were useful for the treatment of HHV-6 infection after BMT. HHV-6 is an important agent for the fever of unknown origin, interstitial peumonitis, diarrhea, and myelosuppression after BMT.
Tanaka-Taya
K
K
Department of Pediatrics, Osaka University Medical School.
Okada
S
S
D000212:Acyclovir / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017245:Foscarnet / Q000627:therapeutic use; D015774:Ganciclovir / Q000627:therapeutic use; D006566:Herpesviridae Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000302:isolation & purification; D016199:Herpesvirus 7, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D016133:Polymerase Chain Reaction; D005719:gamma-Globulins / Q000008:administration & dosage
D000914:Antibodies, Viral; D000998:Antiviral Agents; D005719:gamma-Globulins; D017245:Foscarnet; D015774:Ganciclovir; D000212:Acyclovir