title: Release of interleukin-1 beta from peripheral blood monocytes and its concentration in the blood serum of the workers employed at the production of chlorfenvinphos.
abstract: Our earlier investigations of people exposed to chlorfenvinphos revealed obstructive impairment of pulmonary function and changes in collagen metabolism. In order to evaluate the role of interleukin-1 beta in the development of these changes the serum interleukin-1 beta concentration and the ability of spontaneous and LPS stimulated production of interleukin-1 beta by monocytes were determined in 25 males aged 33-54 years and employed at the department producing chlorfenvinphos (its air concentration did not exceed permissible levels). Higher spontaneous production of interleukin-1 beta was found; the remaining parameters did not differ significantly as compared to the control group of 23 healthy males.
authors.affiliation: IInd Department of Microbiology, Silesian Medical University School in Katowice.
authors.forename: P
authors.initials: P
authors.lastname: Kłuciński
authors.forename: S
authors.initials: S
authors.lastname: Kossmann
authors.forename: D
authors.initials: D
authors.lastname: Friedek
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002617:Chemical Industry; D002709:Chlorfenvinphos / Q000009:adverse effects*; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000201:enzymology*; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D007375:Interleukin-1; D002709:Chlorfenvinphos