title: A predictive value of carcinoembryonic antigen in draining venous blood for colorectal cancer patients with postoperative hematogenous metastases.
abstract: Correlations between carcinoembryonic antigen (CEA) levels of peripheral (p) and draining (d) venous blood and postoperative hematogenous metastases (HM) were examined in 76 advanced (T2-4) colorectal adenocarcinoma patients, to clarify a predictive value of dCEA and the gradient (d-pCEA) between d- and pCEA levels in patients with HM. HM were found in 19 patients (HM group), but not found in 57 patients (non-HM group). The mean value (27.4 ng/ml) of dCEA and positive rates (100 and 89.5%) of d- and d-pCEA levels were significantly higher than those (9.8 ng/ml and 57.9%) of pCEA in the HM group, though no significant difference was found among p-, d-, and d-pCEA values and positive rates in the non-HM group. Significant linear correlations, Y (log dCEA, ng/ml) = -0.039X (month) + 2.016 and Y (log d-pCEA, ng/ml) = -0.039X (month) + 1.823, were found between d- and d-pCEA levels and HM-diagnostic period. These results suggest that colorectal cancer patients with HM are more effectively predicted by the determination of d- and d-pCEA levels than of pCEA levels and that they are patients with positive d- and d-pCEA levels. These patients seem to have a high possibility of early HM.
authors.affiliation: Faculty of Health Science, Kobe University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tabuchi
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Kuniyasu
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000556:secondary* / Q000601:surgery; D002272:Carcinoembryonic Antigen / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D006801:Humans; D011237:Predictive Value of Tests; D013223:Statistics as Topic
chemical_list: D002272:Carcinoembryonic Antigen