Tacrine improves working memory deficit caused by permanent occlusion of bilateral common carotid arteries in rats.
Effect of tacrine, a cholinesterase inhibitor, on spatial acquisition deficit caused by permanent occlusion of bilateral common carotid arteries (2VO) was examined by using the conventional 8-arm and the 4-arm baited radial maze tasks in rats. Daily administration of tacrine (0.1 and 0.3 mg/kg, i.p.) 1 month after 2VO operation significantly improved the impaired spatial acquisition in the conventional maze task. This treatment also ameliorated the 2VO-induced working but not reference memory deficit in the 4-arm baited radial maze task. These results suggest that tacrine improvement of working memory deficit in the 2VO rats is due to stimulation of central cholinergic systems.
Murakami
Y
Y
Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Sugitani, Japan.
Tanaka
E
E
Sakai
Y
Y
Matsumoto
K
K
Li
H B
HB
Watanabe
H
H
D000818:Animals; D017536:Carotid Artery, Common / Q000503:physiopathology; D016893:Carotid Stenosis / Q000150:complications*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008026:Ligation; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology*; D018697:Nootropic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013037:Spatial Behavior / Q000187:drug effects*; D013619:Tacrine / Q000008:administration & dosage / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D018697:Nootropic Agents; D013619:Tacrine