Giving selenium supplements to dairy cows strengthens the inflammatory response to intramammary infection and induces a growth-suppressing effect on mastitis pathogens in whey.
Supplementing the feed of selenium-deficient diary cows with selenium (Se)-yeast or selenite at a level of 0.2 p.p.m. induced self-cure of subclinical mastitis; the prevalence of quarters harbouring subclinical mastitis (bacteriological criteria) decreased to about one half during the 8 week supplementation period. Three phenomena became apparent to explain the beneficial effect of selenium on mastitis: 1. The recruitment of phagocytes to the infected milk compartment of the udder was improved due to Se-supplementation; the correlation between infection and the respective inflammatory response, as indicated by the somatic cell count (SCC) and the N-acetyl-beta-D-glucosaminidase activity (NAGase) of milk, was poor in selenium-deficient cows. Selenium supplementation significantly improved the correlation; 2. Selenium supplementation induced an unspecified antibacterial activity in milk lactoserum (whey), restricting in vitro growth of the mastitis pathogens Escherichia coli, Staphylococcus aureus, Streptococcus agalactiae and Streptococcus uberis, bacterial growth rates in whey samples became inversely correlated with the respective blood glutathione peroxidase activities (GSH-Px); and 3. Selenium supplementation had an effect on redox activities and sulfhydryl activities in whey. These changes were correlated with in vitro bacterial growth rates.
Ali-Vehmas
T
T
Department of Clinical Sciences, Faculty of Veterinary Medicine, Helsinki University, Finland.
Vikerpuur
M
M
Fang
W
W
Sandholm
M
M
D000818:Animals; D002417:Cattle; D003611:Dairy Products / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D005260:Female; D008414:Mastitis, Bovine / Q000382:microbiology / Q000503:physiopathology*; D008892:Milk / Q000166:cytology / Q000201:enzymology / Q000382:microbiology; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D013291:Streptococcus / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification
D012643:Selenium