[Activity and concentration determinations of coagulation factors in conventional and virus-inactivated coagulation-active plasma].
Deep-frozen conventional plasma without viral inactivation [fresh frozen plasma (FFP)] and virus-inactivated plasma units [solvent/detergent (SD) procedure, methylene blue/illumination (MB) procedure] were investigated with regard to their contents of particles and their activities and concentrations, respectively, of blood clotting factors. Particles could be proved in FFP and in MB-treated plasma, but not in SD-treated plasma. Results of the global tests prothrombin time, partial thromboplastin time and thrombin time as well as the activities of blood clotting factors were located in normal range in SD-treated plasma. However, pathological results were partly found in MB-treated plasma. Activities of protein S and alpha 2-antiplasmin were lessened in SD-treated plasma. FFP and MB-treated plasma showed interindividual variations of outcomes (single-donor plasma units) in contrast to SD-treated plasma (pooled donor plasma units).
Lutze
G
G
Institut für Klinische Chemie, Universitätsklinikum, Otto-von-Guericke-Universität Magdeburg, Deutschland.
Hartung
K J
KJ
D001779:Blood Coagulation Factors / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D010314:Partial Thromboplastin Time; D010949:Plasma / Q000737:chemistry* / Q000821:virology; D010976:Platelet Count; D011517:Prothrombin Time
D001779:Blood Coagulation Factors
Aktivitäts- und Konzentrationsbestimmungen von Gerinnungsfaktoren in konventionellen und virusinaktivierten gerinnungsaktiven Plasmen.