[Experimental data on pharmacological effects of new phenothiazine derivatives].
A variety of triazoles and thiadiazoles linked to the N-atom of the phenothiazine through a two carbon atoms chain have been submitted to preliminary toxicological screening (DL50 and DMT). Two derivatives have been selected for the specific pharmacological evaluation. It has been noted a diminution of the exploratory capacity without the muscle tonus, the balance and the capacity of becoming normal again of the tested animals (mice and rats) being affected.
Bâcu
E
E
Faculté de Chimie, Université AI. I. Cuza Iasi, România.
Petrovanu
M
M
Antohie
C
C
Ciocoiu
I
I
Mungiu
O C
OC
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D007928:Lethal Dose 50; D010640:Phenothiazines / Q000494:pharmacology*
D014150:Antipsychotic Agents; D010640:Phenothiazines
Données expérimentales concernant les effets pharmacologiques de quelques nouveaux dérivés phénothiaziniques.