title: [The clinico-epidemiological premises for antioxidant prevention and treatment in chronic myocardial infarct].
abstract: The improvement of therapeutic and recoverable proceeding to chronic myocardial infarction (IMC) imposes a complex epidemiological estimation of the global cardiovascular risk, of their clinical and biological status. The retrospective evaluation of the risk factors (RF) by epidemiological methods, in 38 hospitalized prevalence of both constitutional and behavioral factors, and the quantification of the risk state, according to graph Euro 194, has pointed on the fact that 50% of IMC cases have presented a global risk of 10-20%. That justified the application of a preventive conduct in order to continually neutralize the associates FR. The biochemical determinations have allowed to frame the dyslipidemic patients, according to the ARCOL classification in the classes D (29.2%), E (25.0%) and B (20.8%) with direct implication in the adopted therapy. The colorimetric dozing with thyo-barbituric acid of the malonly dialdehyde (MAD) each is a product of the lipidic peroxidation, as well as the interpreting or correlation of the registered values with an evolutive clinic stage, and with the existence of some existing diseases (diabetes, chronic hepatitis etc.) along with signification of other dismethabolical parameters (cholesterol, triglycerides, LDLc, apoB) have confirmed the necessity of a complex therapy, including an antioxidative treatment, having the role to directly inhibit or exclude the free radicals resulted after the oxidative stress of the infarct.
authors.affiliation: Disciplina de Epidemiologie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: D
authors.initials: D
authors.lastname: Azoicăi
authors.forename: F
authors.initials: F
authors.lastname: Mitu
authors.forename: A
authors.initials: A
authors.lastname: Iacobovici
authors.forename: M
authors.initials: M
authors.lastname: Pavel
authors.forename: L
authors.initials: L
authors.lastname: Jerca
authors.forename: D
authors.initials: D
authors.lastname: Ungureanu
authors.forename: I
authors.initials: I
authors.lastname: Popovici
authors.forename: M
authors.initials: M
authors.lastname: Cojocaru
authors.forename: A
authors.initials: A
authors.lastname: Ivan
authors.forename: N
authors.initials: N
authors.lastname: Gheorghiţă
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D002908:Chronic Disease; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D011379:Prognosis; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology
chemical_list: D000975:Antioxidants; D008055:Lipids; D008074:Lipoproteins
vernacular_title: Premisele clinico-epidemiologice pentru prevenţia şi tratamentul antioxidant în infarctul miocardic cronic.