title: Agelastatins C and D, new pentacyclic bromopyrroles from the sponge Cymbastela sp., and potent arthropod toxicity of (-)-agelastatin A.
abstract: Two new agelastatins, C (3) and D (4), along with the known compound (-)-agelastatin A (1), were isolated from the Indian Ocean sponge Cymbastela sp. The structures were determined by analysis of spectroscopic data and chemical correlation of 4 with a common derivative 5, also prepared from 1. Agelastatin A (1) exhibited potent activity against brine shrimp (LC50 1.7 ppm) in addition to insecticidal activity against larvae of beet army worm, Spodoptera exigua, and corn rootworm, Diabrotica undecimpunctata.
authors.affiliation: Department of Chemistry, University of California, Davis 95616, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Hong
authors.forename: D R
authors.initials: DR
authors.lastname: Jímenez
authors.forename: T F
authors.initials: TF
authors.lastname: Molinski
mesh_terms: D000818:Animals; D001156:Artemia; D007313:Insecta; D007306:Insecticides / Q000302:isolation & purification* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D018411:Spodoptera
chemical_list: D007306:Insecticides