The effect of tamoxifen on the neonatal development of rat glans penis.
From the first day of birth to the fifth day, daily subcutaneous 100 micrograms tamoxifen (Tx) was injected into new-born male rats. The penises that were taken totally were fixated in 10% formaline, and then they were put in paraffin inclusion. The paraffin sections were stained with Hematoxylen-Eosin, Verhoeff and Triple on days 7, 14, 21, 28, 35 and 60. The alterations in the development of glans penis construction were examined. We found that in the glans penis of animals which were given Tx, from the 21st day, the epidermal projections were erased slowly and on the 60th day the epidermal projections and keratinisation completely ceased altogether. As a result, the development of epidermal projections in rats which were given tamoxifen in the neonatal period were hindered.
Deveci
E
E
Department of Histology and Embryology, Medical Faculty, University of Dicle, Diyarbakir, Türkiye.
Onen
A
A
Tacar
O
O
Yildirim
A
A
D000818:Animals; D000831:Animals, Newborn; D001284:Atrophy; D004817:Epidermis / Q000187:drug effects* / Q000254:growth & development* / Q000473:pathology; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D004965:Estrogen Antagonists / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007633:Keratins / Q000378:metabolism; D008297:Male; D010413:Penis / Q000187:drug effects* / Q000254:growth & development*; D051381:Rats; D013629:Tamoxifen / Q000008:administration & dosage / Q000494:pharmacology*
D004965:Estrogen Antagonists; D013629:Tamoxifen; D007633:Keratins