[Neurotoxicity of penicillin and other beta-lactam antibiotics--importance in clinical practice].
Epileptogenic properties of penicillin, applied either directly to the brain or systemically, have been known for many years and may be also of clinical importance. In the present work different aspects of this action, including clinical ones, as well as risk factors for the occurrence of epileptic seizures, and mechanism of penicillin action in the central nervous system have been shortly described. Moreover, results of experimental studies confirming epileptogenic properties of many antibiotics, mainly b-lactams, have been mentioned. Data from experimental studies, revealing the possibility of long-term adverse effects of repeated injections of convulsants, have been emphasized, and the absence of relevant clinical studies has been pointed out. Widespread usage of beta-lactam antibiotics should encourage medical personnel to pay more attention to all these problems in everyday clinical practice.
Gralewicz
S
S
Zakładu Oceny Toksyczności, Instytutu Medycyny Pracy w Lodzi.
Walusiak-Stankiewicz
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000633:toxicity; D004827:Epilepsy / Q000139:chemically induced; D006801:Humans; D010406:Penicillins / Q000009:adverse effects* / Q000633:toxicity; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D010406:Penicillins; D047090:beta-Lactams
Neurotoksyczność penicyliny i innych antybiotyków beta-laktamowych--znaczenie w praktyce klinicznej.