title: Relationship between thyroid hormones and plasma D-dimer levels.
abstract: High serum levels of cholesterol and triglycerides are risk factors for coronary heart disease and are strongly related to several haemostatic parameters. Thyroid disorders are a frequent feature in hyperlipidemic patients and are also associated with a variety of haemostatic abnormalities. Therefore, we analysed the relationships between free T4 (fT4) levels and Factor VII and VIII activities (FVIIc and FVIIc), D-Dimers (DDI) and Plasminogen Activator Inhibitor type 1 (PAI-1), in a group of 472 healthy patients referred for hyperlipidemia. Fourty patients were found to have primary hypothyroidism. A negative correlation was found in the whole study population between fT4 and DDI (p = 0.0001, r = -0.21) and the same results were found after exclusion of the patients with fT4 below the normal range (p = 0.0007, r = -0.17). In a multivariate regression analysis, the relationship between DDI and fT4 was independent of age, Body Mass Index (BMI), gender and total cholesterol. Less impressive correlation coefficients were found with FVIIc (r = -0.10), FVIIIc (r = -0.09) and PAI-1 (r = -0.09). These results suggest that fT4 may play a physiological role in the regulation of the haemostatic equilibrium in hyperlipidemic patients and that low levels of fT4 are associated with a hypercoagulable state.
authors.affiliation: Service d'Endocrinologie-Métabolisme, Hôpital Pitié Salpétrière, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Chadarevian
authors.forename: E
authors.initials: E
authors.lastname: Bruckert
authors.forename: A
authors.initials: A
authors.lastname: Ankri
authors.forename: I
authors.initials: I
authors.lastname: Beucler
authors.forename: P
authors.initials: P
authors.lastname: Giral
authors.forename: G
authors.initials: G
authors.lastname: Turpin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation / Q000502:physiology*; D015986:Confounding Factors, Epidemiologic; D005167:Factor VII / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005342:Fibrinolysis / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D013974:Thyroxine / Q000097:blood*
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; D005167:Factor VII; D005169:Factor VIII; D013974:Thyroxine