title: [Physical trauma and multiple sclerosis].
abstract: Without a more detailed knowledge of etiology and pathogenesis of multiple sclerosis final conclusions regarding an association between physical trauma and the onset or course of multiple sclerosis cannot be drawn. Only a few prospective studies which are appropriately designed to prove a putative correlation have been published. A critical review of these studies and some case reports, in the light of the current pathophysiological concepts of multiple sclerosis, does not indicate a causal relationship between physical trauma and onset of multiple sclerosis or exacerbations.
authors.affiliation: Klinische Forschungsgruppe für Multiple Sklerose, Neurologische Klinik und Poliklinik, Julius-Maximilians-Universität, Würzburg.
authors.forename: F X
authors.initials: FX
authors.lastname: Weilbach
authors.forename: H P
authors.initials: HP
authors.lastname: Hartung
mesh_terms: D002490:Central Nervous System / Q000503:physiopathology; D016489:Head Injuries, Closed / Q000150:complications / Q000503:physiopathology; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology* / Q000503:physiopathology; D009186:Myelin Sheath / Q000502:physiology; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D012307:Risk Factors; D014947:Wounds and Injuries / Q000150:complications* / Q000503:physiopathology
vernacular_title: Physikalisches Trauma und multiple Sklerose.