title: New method for determining prognosis of patients with psoriasis (E-PAP).
abstract: We developed a new method for evaluating clinical symptoms of psoriasis during the observation period, by adding a parameter of time (the number of days) to the psoriasis area and severity index (PASI). This method was named the evaluation for prognosis with averaged PASI (E-PAP). Using this method, we assessed 14 cases to determine the following items: (1) clinical symptoms during the observation period; (2) clinical effects of treatments; (3) patient's satisfaction with treatments; and (4) necessity for additional and/or alternate treatments. We evaluated the usefulness of E-PAP in determining the prognosis of patients with psoriasis by comparing the uninterrupted monotherapy and intermittent therapy with cyclosporin A (Cys A). Although there were no differences in Cys A dosages after remission as well as adverse reactions between the two groups, the E-PAP value was significantly different between them. These results suggest that this method may be useful for determining the prognosis of patients with psoriasis.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Sugai
authors.forename: A
authors.initials: A
authors.lastname: Ozawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kawakubo
authors.forename: M
authors.initials: M
authors.lastname: Iizuka
authors.forename: M
authors.initials: M
authors.lastname: Miyahara
authors.forename: M
authors.initials: M
authors.lastname: Ohkido
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D006801:Humans; D008722:Methods; D011379:Prognosis; D011565:Psoriasis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D012074:Remission Induction; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D018501:Antirheumatic Agents; D016572:Cyclosporine