[Selective adsorption of cryoglobulins from plasma of three patients with mixed type II cryoglobulinemia].
A new immunoadsorption column using Sepharose CL 4B as carrier material and IgG as covalently bound ligand was applied for the treatment of three patients with mixed type II kryoglobulinaemia. The titers of rheumatoid factors and cryoglobulins could be significantly decreased during each treatment. The removal of both correlated with the clinical improvement. Skin ulcers, refractory to conventional therapy and arthropathical complaints decreased considerably or disappeared. Further studies evaluating the pathomechanisms and the predictivity of the results must be performed.
Jiménez Klingberg
C
C
Hämapherese, Universitätskliniken Köln, Deutschland.
Borberg
H
H
Belac
M
M
Späth
P
P
D003449:Cryoglobulinemia / Q000097:blood / Q000145:classification / Q000628:therapy*; D003450:Cryoglobulins / Q000032:analysis / Q000302:isolation & purification*; D006801:Humans; D007163:Immunosorbent Techniques; D012217:Rheumatoid Factor / Q000097:blood; D012685:Sepharose / Q000031:analogs & derivatives
D003450:Cryoglobulins; C036210:immunoglobulin G-sepharose; D012217:Rheumatoid Factor; D012685:Sepharose
Selektive Adsorption von Kryoglobulinen aus dem Plasma von drei Patienten mit gemischter Typ-II-Kryoglobulinämie.