[Antibiotic resistance among strains of Helicobacter pylori in Gothenburg. Bacteria resistant to metronidazole].
OBJECTIVE
Primary resistance of H pylori strains to antimicrobials has direct therapeutical implications. For this reason we studied the prevalence of primary resistance of H pylori of Sweden, in a regional setting.


METHODS
A total of 244 patients referred to our endoscopy unit have been evaluated prospectively for the occurrence of H pylori. Helicobacter pylori infection was established by a positive rapid urease test on an antral biopsy. If positive the biopsy specimen was transferred to a transportmedium for culture on a Skirrow medium. Antimicrobial resistance was evaluated by the E-test.


RESULTS
In 109 patients H pylori infection was seen and in all of them the culture was positive. No resistance was seen for amoxycillin and tetracycline. The resistance against metronidazole was 40.3% and and against clarithromycin it was 2.8%. For metronidazole there was a significantly higher resistance seen in women compared to men (53.3% vs 31.2%; p < 0.001).


CONCLUSIONS
Primary resistance to metronidazole was higher than expected and over average in Europe. The resistance for clarithromycin is still rare. Further monitoring is mandatory to detect changes in the community.
Jaup
B H
BH
Medicinkliniken, Lundby sjukhus.
Brandberg
A
A
Stenquist
B
B
Norrby
A
A
D000994:Antitrichomonal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000276:immunology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000009:adverse effects / Q000627:therapeutic use*; D013548:Sweden
D000994:Antitrichomonal Agents; D008795:Metronidazole
Antibiotikaresistens hos stammar av Helicobacter pylori i Göteborg. Bakterierna resistenta mot metronidazol.