Three new bistetrahydrofuran acetogenins from the seeds of Annona spinescens.
Three new bistetrahydrofuran acetogenins, carolins A-C (1-3), were isolated from the MeOH extract of Annona spinescens in addition to the known compound, squamocin (4). The structures of 1, 2, and 3 were elucidated by spectroscopic methods including LSIMS/MS technique and confirmed by a chemical transformation, The cytotoxic activity of the new compounds 1-3 is reported and discussed in comparison with 4 and the previously isolated spinencin (5).
Queiroz
E F
EF
Laboratoire de Pharmacognosie, U.R.A. 1843 CNRS (BIOCIS), Faculté de Pharmacie, Châtenay-Malabry, France.
Roblot
F
F
Figadère
B
B
Laurens
A
A
Duret
P
P
Hocquemiller
R
R
Cavé
A
A
Serani
L
L
Laprévote
O
O
Cotte-Laffitte
J
J
Quéro
A M
AM
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D000972:Antineoplastic Agents, Phytogenic; D005233:Fatty Alcohols; C110790:carolin A; C110791:carolin B; C110792:carolin C; D015107:4-Butyrolactone