The effect of fluoride on Streptococcus sanguis 7863 IgA1 protease production and activity.
Fluoride was found to affect the production of the bacterial IgA1 protease but to have no effect on IgA1 protease activity. The concentrations of fluoride that do affect Streptococcus sanguis growth and IgA1 protease production are higher than those normally seen in vivo under normal circumstances. The concentrations of fluoride in dental plaque following use of a fluoride rinse or dentifrice would be sufficient to reduce Strep. sanguis IgA1 protease production.
Duguid
R
R
Department of Conservative Dentistry, University of Dundee, Scotland, U.K.
Senior
B W
BW
D002327:Cariostatic Agents / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D003773:Dental Plaque / Q000737:chemistry; D003802:Dentifrices / Q000627:therapeutic use; D004591:Electrophoresis, Polyacrylamide Gel; D005459:Fluorides / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000187:drug effects* / Q000378:metabolism; D009067:Mouthwashes / Q000627:therapeutic use; D012697:Serine Endopeptidases / Q000096:biosynthesis / Q000187:drug effects* / Q000378:metabolism; D012967:Sodium Dodecyl Sulfate; D013298:Streptococcus sanguis / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D013501:Surface-Active Agents
D002327:Cariostatic Agents; D003802:Dentifrices; D007070:Immunoglobulin A; D009067:Mouthwashes; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D012697:Serine Endopeptidases; C021433:IgA-specific serine endopeptidase; D005459:Fluorides