title: [Immunization against a new, infrequent alloantigen (Iy) on the platelet glycoprotein Ib/IX as a cause of a serious case of neonatal alloimmune thrombocytopenia].
abstract: Neonatal alloimmune thrombocytopenia is the consequence of maternal alloimmunization against platelet-specific alloantigens, usually PIA1 or Br(a). The clinical picture is characterized by signs of haemorrhagic diathesis as a result of marked thrombocytopenia. In the last years, rare cases of immunization against 'low-frequency' or 'private' platelet alloantigens on the platelet glycoprotein (GP) complex IIb/IIIa have been found. This is the first report on NAIT due to maternal immunization against a low-frequency platelet alloantigen ('Iy') localized on platelet GP Ib/IX.
authors.affiliation: Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen, Deutschland.
authors.forename: V
authors.initials: V
authors.lastname: Kiefel
authors.forename: M
authors.initials: M
authors.lastname: Vicariot
authors.forename: C
authors.initials: C
authors.lastname: Breitfeld
authors.forename: A
authors.initials: A
authors.lastname: Giptner
authors.forename: C
authors.initials: C
authors.lastname: Schlüter
authors.forename: M
authors.initials: M
authors.lastname: Böhringer
authors.forename: S
authors.initials: S
authors.lastname: Santoso
authors.forename: H
authors.initials: H
authors.lastname: Kroll
authors.forename: C
authors.initials: C
authors.lastname: Mueller-Eckhardt
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology*; D011247:Pregnancy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*
chemical_list: C110429:12bw alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies; D019038:Platelet Glycoprotein GPIb-IX Complex
vernacular_title: Immunisierung gegen ein neues, niedrigfrequentes Alloantigen (Iy) auf dem thrombozytären Glykoprotein Ib/IX als Ursache für einen schweren Fall von neonataler Alloimmunthrombozytopenie.