[Finasteride and flutamide in the treatment of hirsutism].
BACKGROUND
The aim of this work was to evaluate the efficacy of two new antiandrogen drugs, finasteride and flutamide, in 80 hirsute patients: 44 with Polycystic Ovary Syndrome (PCOS) and 36 with Idiopathic Hirsutism (IH).


METHODS
The study was conducted in a randomized way and randomization was carried out according to hospitalization. Before and after the treatment, all of the patients underwent hematochemical tests, hormone assays and assessment of hirsutism with the Ferriman Gallway score (F.G. score) and with measurement of the hair diameter in four different body areas. Finasteride was administered per os to 40 women at the dose of 5 mg/die; flutamide per os to 40 women at the dose of 250 mg twice daily. Both drugs were employed for 6 consecutive months.


RESULTS
Both finasteride and flutamide significantly reduced the F.G. score and hair diameter.


CONCLUSIONS
Abdominal hairs were more sensitive to the therapy.
Falsetti
L
L
Dipartimento di Ginecologia Endocrinologica, Università degli Studi, Brescia.
De Fusco
D
D
Rosina
B
B
D000284:Administration, Oral; D000328:Adult; D000726:Androgen Antagonists / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D018120:Finasteride / Q000627:therapeutic use*; D005485:Flutamide / Q000627:therapeutic use*; D006628:Hirsutism / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000150:complications*
D000726:Androgen Antagonists; D018120:Finasteride; D005485:Flutamide
Finasteride e flutamide nel trattamento dell'irsutismo.