The effect of ethanolamine on acute carbon tetrachloride intoxication.
The effects of ethanolamine on injured liver were investigated by oral administration of ethanolamine to male ddY mice 24 h after carbon tetrachloride (CCl4) injection. The serum aminotransferase activities in mice with liver injury were reduced by ethanolamine treatment (10-30 mg/kg body weight). Drastically increased regenerative reaction of ethanolamine treated-CCl4 injured liver was also observed through an increase in 5-bromo-2'-deoxyuridine uptake. ATP concentration in liver tissue was recovered by administration of ethanolamine. These results suggest that oral administration of ethanolamine accelerates recovery from CCl4-induced liver injury.
Murakami
T
T
Department of Pharmaceutics, Gifu Pharmaceutical University, Mitahora-higashi, Japan.
Nagamura
Y
Y
Hirano
K
K
D000255:Adenosine Triphosphate / Q000378:metabolism; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D004247:DNA / Q000096:biosynthesis; D019856:Ethanolamine / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D019856:Ethanolamine; D000255:Adenosine Triphosphate; D004247:DNA; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase