Concept of the noncoenzymatic thiamine effect.
The experimental and clinical data on different aspects of vitamin and hormone relationships have been summarized in the form of a general concept of the noncoenzymatic thiamine effect, on the basis of a number of premises: (1) discovery of tissue factors limiting the manifestation of the specific activity of administered thiamine (the presence of a tissue buffer depot of easily accessible coenzymes, and lack of free apoenzymes); (2) evidence of a thiamine effect on the pancreatic insulin-synthesizing function; (3) stimulation of metabolic thiamine effects, including the effects of insulin administration on thiamine-dependent enzymes; (4) determination of the features of hormonal control of thiamine metabolism in the body; (5) confirmation of the predictive force of the concept by clinical trials of the new strategy of thiamine therapy.
Vinogradov
V V
VV
Institute of Biochemistry, Academy of Sciences of Belarus, Grodno.
Vodoyevich
V P
VP
Rozhko
A V
AV
Vinogradov
S V
SV
D000818:Animals; D001051:Apoenzymes / Q000378:metabolism; D003067:Coenzymes; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000096:biosynthesis / Q000494:pharmacology; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D008954:Models, Biological; D013831:Thiamine / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D014815:Vitamins / Q000502:physiology
D001051:Apoenzymes; D003067:Coenzymes; D006728:Hormones; D007328:Insulin; D014815:Vitamins; D013831:Thiamine