[Resuscitation necessitated by a transfusion reaction after HLA mismatched platelets substitution].
A severe nonhemolytic transfusion reaction occurred to a polytransfused leukemic patient as a life-threatening anaphylactic shock with cardio-pulmonary arrest following the transfusion of HLA-nonadapted/mismatched platelets. As the only potential causative agent a lymphocytotoxic antibody with the specificity anti-HLA-A2 has been found. The HLA antibody reacted up to a dilution of 1:2,048. The recipient was negative for the corresponding antigen, but HLA-2 was present on donor's platelets. This observation demonstrates again the clinical value of HLA-matched platelet transfusion in patients who need long-term support.
Kuntz
B M
BM
Institut für Blutgerinnung und Transfusionsmedizin Medizinische Einrichtungen der Heinrich-Heine-Universität Düsseldorf, Deutschland.
Schöttler
B
B
Brüster
H T
HT
D000707:Anaphylaxis / Q000209:etiology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003602:Cytotoxicity, Immunologic; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006680:HLA Antigens / Q000276:immunology*; D006323:Heart Arrest / Q000209:etiology*; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000628:therapy*; D017713:Platelet Transfusion / Q000009:adverse effects*; D012151:Resuscitation
D006680:HLA Antigens; D007518:Isoantibodies; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
Reanimationsbedürftige Transfusionsreaktion nach HLA-unangepasster Thrombozytensubstitution.