[Effect of rifampicin, endotoxin, and their combination on the phagocyte activity, microsomal oxidation, and free radical processes in the liver].
Experiments were conducted on mices to study the effect of strain MRe-600 Escherichia coli endotoxin, rifampicin, and their combination at the level of cytochrome p-450, b5, aminopyrine N-demethylase and aniline-r-hydroxylase activity in the liver, absorptive activity and oxygen dependent metabolism of macrophages, and free-radical processes in the liver. It was found that rifampicin removes the endotoxin-induced depression of microsomal oxidation in the liver, but potentiates the stimulating effect of the endotoxin on macrophageal absorptive activity and the "respiratory outburst" in these cells. The oxidative equilibrium in the liver in this case does not change.
Sibiriak
S V
SV
Department of Immunology and Immunopharmacology, Russian Center of Eye and Plastic Surgery, Ufa, Russia.
Sergeeva
S A
SA
Kurchatova
N N
NN
Iusupova
R Sh
RSh
Kireev
V L
VL
Khaĭbullina
S F
SF
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015786:Cytochromes b5 / Q000378:metabolism; D004347:Drug Interactions; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005609:Free Radicals / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010084:Oxidation-Reduction; D016897:Respiratory Burst / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D004731:Endotoxins; D005609:Free Radicals; C044101:endotoxin, Escherichia coli; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; C019666:amidopyrine N-demethylase; D012293:Rifampin
Vliianie rifampitsina, éndotoxina i ikh kombinatsii na aktivnost' fagotsitov, mikrosomal'noe okislenie i svobodno-radikal'nye protsessy v pecheni.