Influence of osteoarthritis on serum marker levels of bone formation and resorption in patients with benign prostatic hypertrophy.
BACKGROUND
The aim of this study was to investigate the influence of osteoarthritis of lumbar vertebrae on serum bone formation and resorption marker levels of patients with benign prostatic hypertrophy (BPH).


METHODS
Serum levels of carboxyterminal propeptide of type I procollagen (PICP), alkaline phosphatase (ALP), carboxyterminal telopeptide of type I collagen (ICTP), and prostate-specific antigen (PSA) were examined in 40 patients with BPH, and the presence of osteoarthritis at the lumbar vertebrae of the patients was evaluated by plain x-ray-p.


RESULTS
Findings of osteoarthritis were observed in 23 of the 40 patients (58%), and 10 of the patients had severe osteoarthritis (involving at least 2 lumbar vertebral bodies). The serum levels of PICP, ALP, ICTP, and PSA of the patients without osteoarthritis findings were not different from those of the patients with osteoarthritis or severe osteoarthritis.


CONCLUSIONS
The influence of osteoarthritis on serum bone formation and resorption marker levels of patients with BPH appears to be rather slight, if there is any influence at all.
Akimoto
S
S
Department of Urology, School of Medicine, Chiba University, Japan.
Furuya
Y
Y
Akakura
K
K
Shimazaki
J
J
Ito
H
H
D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001846:Bone Development; D001862:Bone Resorption / Q000097:blood* / Q000000981:diagnostic imaging; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D011347:Procollagen / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000150:complications; D011859:Radiography; D011863:Radioimmunoassay; D012189:Retrospective Studies; D013128:Spinal Osteophytosis / Q000097:blood* / Q000000981:diagnostic imaging
D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D003094:Collagen; D000469:Alkaline Phosphatase; D017430:Prostate-Specific Antigen