A century of (epithelial) transport physiology: from vitalism to molecular cloning.
During the past century, the generally accepted view of the function of biological membranes has evolved from that of a static, inert lipoprotein envelope that simply separates the intracellular machinery from the outside milieu, to that of a dynamic structure that is, in fact, an integral part of that machinery actively involved in homeostasis and bioenergetics. This brief review traces that paradigm shift with special emphasis on the evolution of central concepts in epithelial transport physiology.
Schultz
S G
SG
Department of Integrative Biology and Pharmacology, University of Texas Medical School, Houston 77225, USA.
D000818:Animals; D001692:Biological Transport; D003001:Cloning, Molecular; D004847:Epithelial Cells / Q000502:physiology*; D049672:History, 19th Century; D049673:History, 20th Century; D008954:Models, Biological; D010506:Periodicals as Topic / Q000266:history; D010827:Physiology / Q000266:history*; D014481:United States