title: Effect of clinical doses of fluoxetine on psychological variables in healthy volunteers.
abstract: OBJECTIVE
  The authors sought to determine the effect of clinically equivalent doses of fluoxetine on mood and other psychological variables in normal subjects.
  
  
  METHODS
  Fifteen healthy volunteers received placebo for 2 weeks; fluoxetine, 10 mg/day, for 1 week; fluoxetine, 20 mg/day, for 5 weeks; and then an additional 2 weeks of placebo in the context of a single-blind study. The subjects were evaluated with a series of self- and observer-rated instruments.
  
  
  RESULTS
  No significant effects attributable to fluoxetine were observed on any of the psychological variables examined. Minimal adverse effects were reported.
  
  
  CONCLUSIONS
  Significant mood-elevating and other psychological effects of fluoxetine would appear to be induced only when symptomatic targets exist.
authors.affiliation: Department of Psychiatry, Hadassah-Hebrew University Medical Center, Kiryat Hadassah-Ein Karem, Jerusalem, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Gelfin
authors.forename: M
authors.initials: M
authors.lastname: Gorfine
authors.forename: B
authors.initials: B
authors.lastname: Lerer
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010549:Personal Satisfaction; D010551:Personality / Q000187:drug effects*; D010555:Personality Inventory; D010919:Placebos; D011788:Quality of Life; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D005473:Fluoxetine; D010919:Placebos; D017367:Selective Serotonin Reuptake Inhibitors