title: Reduced Loa loa microfilaria count ten to twelve months after a single dose of ivermectin.
abstract: The action of a single dose of ivermectin (200 micrograms/kg) on 71 Gabonese patients with Loa loa microfilariae in the peripheral blood, and living in areas highly endemic for loiasis, has been evaluated. Ten to 12 months after treatment, 43 patients (63%) had no circulating microfilaria and the geometric mean peripheral blood microfilaria count had decreased by 88.6% (P < 0.02). Thus, a single annual dose of ivermectin can markedly reduce loiasis transmission.
authors.affiliation: Faculté de Médecine, Tours, France.
authors.forename: T H
authors.initials: TH
authors.lastname: Duong
authors.forename: M
authors.initials: M
authors.lastname: Kombila
authors.forename: A
authors.initials: A
authors.lastname: Ferrer
authors.forename: P
authors.initials: P
authors.lastname: Bureau
authors.forename: P
authors.initials: P
authors.lastname: Gaxotte
authors.forename: D
authors.initials: D
authors.lastname: Richard-Lenoble
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005681:Gabon; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use*; D008117:Loa / Q000187:drug effects*; D008118:Loiasis / Q000188:drug therapy*; D008297:Male; D008842:Microfilariae / Q000187:drug effects; D008875:Middle Aged
chemical_list: D000969:Antinematodal Agents; D007559:Ivermectin