Neurobehavioral alteration in rodents following developmental exposure to aluminum.
Aluminum (Al) is one of the most abundant metals in the earth's crust, and humans can be exposed to it from several sources. It is present in food, water, pharmaceutical compounds, and in the environment, e.g., as a result of acid rain leaching it from the soil. Exposure to Al has recently been implicated in a number of human pathologies, but it has not yet been definitely proved that it plays a major causal role in any of them. In this paper we review the effects of developmental exposure of laboratory animals to Al salts as a model for human pathological conditions. The data presented show behavioral and neurochemical changes in the offspring of AL-exposed mouse dams during gestation, which include alterations in the pattern of ultrasonic vocalizations and a marked reduction in central nervous system (CNS) choline acetyltransferase activity. Prenatal Al also affects CNS cholinergic functions under Nerve Growth Factor (NGF) control, as shown by increased central NGF levels and impaired performances in a maze learning task in young-adult mice. The need for more detailed studies to evaluate the risks for humans associated with developmental exposure to Al, as well as the importance of using more than one strain of laboratory animal in the experimental design, is emphasized.
Alleva
E
E
Behavioural Pathophysiology Section, Istituto Superiore di Sanità, Roma, Italy. alleva@iss.it
Rankin
J
J
Santucci
D
D
D000284:Administration, Oral; D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007858:Learning / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009414:Nerve Growth Factors / Q000187:drug effects; D009490:Neurosecretory Systems / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014828:Vocalization, Animal / Q000187:drug effects
D009414:Nerve Growth Factors; D000535:Aluminum; D002795:Choline O-Acetyltransferase