title: Tick-borne relapsing fever in the northwestern United States and southwestern Canada.
abstract: Records from 182 cases of tick-borne relapsing fever (TBRF) were reviewed. In confirmed cases, there was febrile illness, and spirochetes were identified on peripheral blood preparations. In probable cases, there were clinical features of TBRF and either the same exposure as a confirmed case or serological (indirect fluorescent antibody test and western blotting [WB]) evidence of infection with Borrelia hermisii. Sera also were tested for antibody to Borrelia burgdorferi. We identified 133 confirmed and 49 probable cases of TBRF. A Jarisch-Herxheimer reaction was reported in 33 (54.1%) of 61 cases for which this information was available. Most patients who had antibodies to B. hermsii were serologically positive for B. burgdorferi, and WB demonstrated false positivity of testing for B. burgdorferi. Thirty-five (21%) of 166 cases were unreported to public health authorities. In 52 cases, there were more than two relapses before the diagnosis. This study demonstrates that TBRF is underrecognized and underreported and may be falsely identified as Lyme disease.
authors.affiliation: Section of Communicable Disease Epidemiology, Washington State Department of Health, Seattle, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Dworkin
authors.forename: D E
authors.initials: DE
authors.lastname: Anderson
authors.forename: T G
authors.initials: TG
authors.lastname: Schwan
authors.forename: P C
authors.initials: PC
authors.lastname: Shoemaker
authors.forename: S N
authors.initials: SN
authors.lastname: Banerjee
authors.forename: B O
authors.initials: BO
authors.lastname: Kassen
authors.forename: W
authors.initials: W
authors.lastname: Burgdorfer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000907:Antibodies, Bacterial / Q000097:blood; D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012061:Relapsing Fever / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial