title: An observer-blind randomised parallel group study comparing the efficacy and tolerability of tenoxicam and piroxicam in the treatment of post-operative pain after oral surgery.
abstract: Tenoxicam and piroxicam were compared for analgesic efficacy in 58 patients undergoing removal of bilateral impacted third molar teeth, under general anaesthesia. Pain intensity was assessed over a 7 day period by the patient using verbal and visual analogue scales. The patients received one hour pre-operatively dormicum 7.5 mg orally and either tenoxicam 40 mg or piroxicam 40 mg rectally. This was followed by tenoxicam 20 mg daily in effervescent form, or piroxicam 20 mg daily in despersible tablet form for 7 days. Surgical and anaesthetic techniques were standardized for all patients. Therapeutic gain was assessed by comparing hourly pain levels 4 hours post-operatively and then twice daily for 7 days. Trismus was evaluated pre-operatively, at one hour, 24 hours and 7 days post-operatively. Analysis of the results showed a statistical significant difference between the treatment groups only 4 hours post-operatively, patients in the tenoxicam group experiencing less pain than those in the piroxicam group (p = < 0.05).
authors.affiliation: Division of Anaesthesia, Faculty of Dentistry, Tygerberg.
authors.forename: J A
authors.initials: JA
authors.lastname: Roelofse
authors.forename: L C
authors.initials: LC
authors.lastname: Swart
authors.forename: I A
authors.initials: IA
authors.lastname: Stander
mesh_terms: D000293:Adolescent; D000328:Adult; D000766:Anesthesia, Dental; D000768:Anesthesia, General; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D010147:Pain Measurement / Q000706:statistics & numerical data; D010149:Postoperative Pain / Q000188:drug therapy*; D010894:Piroxicam / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D016037:Single-Blind Method; D013488:Suppositories; D013607:Tablets; D014081:Tooth Extraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013488:Suppositories; D013607:Tablets; D010894:Piroxicam; C032801:tenoxicam