title: Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy.
abstract: 5-Oxoprolinuria is a recognized condition with increased urinary excretion of 5-oxoproline and is associated with a variety of inborn metabolic defects involving the series of enzyme-linked reactions known as the gamma-glutamyl cycle. We report the unusual case of a 35-year-old woman who initially presented with staphylococcal pneumonia but went on to develop a transient high anion gap metabolic acidosis. The development and subsequent complete recovery from this acidosis were subsequently shown to be related in time to the intravenous administration of the antibiotics flucloxacillin and netilmicin. Analysis of the patient's urine for organic acids revealed massively increased excretions of 5-oxoproline at the peak of her acidosis. We suggest that this patient developed a transient disturbance in the gamma-glutamyl cycle involving the 5-oxoprolinase step, which resulted in accumulation of 5-oxoproline that caused a severe high anion gap metabolic acidosis. The administered antibiotics remain as possible causative agents.
authors.affiliation: Department of Clinical Biochemistry, Medical School, Aberdeen Royal Infirmary, Foresterhill, UK.
authors.forename: B L
authors.initials: BL
authors.lastname: Croal
authors.forename: A C
authors.initials: AC
authors.lastname: Glen
authors.forename: C J
authors.initials: CJ
authors.lastname: Kelly
authors.forename: R W
authors.initials: RW
authors.lastname: Logan
mesh_terms: D000138:Acidosis / Q000139:chemically induced*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005436:Floxacillin / Q000009:adverse effects / Q000627:therapeutic use; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use; D005978:Glutathione / Q000096:biosynthesis / Q000378:metabolism; D006801:Humans; D009428:Netilmicin / Q000009:adverse effects / Q000627:therapeutic use; D010406:Penicillins / Q000009:adverse effects / Q000627:therapeutic use; D011023:Pneumonia, Staphylococcal / Q000188:drug therapy; D011752:Pyroglutamate Hydrolase / Q000037:antagonists & inhibitors; D011761:Pyrrolidonecarboxylic Acid / Q000652:urine*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D005436:Floxacillin; D009428:Netilmicin; D011752:Pyroglutamate Hydrolase; D005978:Glutathione; D011761:Pyrrolidonecarboxylic Acid