[Effect of the long-term atenolol therapy on the structural and functional parameters of the left ventricle in patients with dilated cardiomyopathy].
The effect of long-term atenolol therapy on the structural and functional parameters of the left-ventricular (LV) myocardium was studied in patients with dilatational cardiomyopathy by means of echocardiography. Six-months treatment with atenolol improved the clinical status and reduced the degree of LV dilatation in patients with circulatory insufficiency of functional classes I and II. The contractility parameters (ejection fraction and delta S) increased in patients of all functional classes but more markedly in those of functional classes I and II. The effect of atenolol on the transmitral diastolic flow in patients with the initial stages of chronic circulatory insufficiency was characterized by the absence of changes in the flow rate during the period of rapid filling and a significant lowering of the atrial peak, which corresponded to improvement in the patients' status.
Sisakian
A S
AS
Department of Internal Diseases No. 1, Erevan State Medical University, Erevan, Armenia.
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D001262:Atenolol / Q000008:administration & dosage / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy* / Q000503:physiopathology; D003326:Coronary Circulation / Q000187:drug effects; D004452:Echocardiography; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D001262:Atenolol
Vliianie dlitel'noĭ terapii atenololom na strukturno-funktsional'nye pokazateli levogo zheludochka u bol'nykh dilatatsionnoĭ kardiomiopatieĭ.