A serotonin-4 receptor-like pseudogene in humans.
During a search for new G-protein-linked receptors for dopamine and serotonin, we found a serotonin-4 receptor-like pseudogene. This receptor-like pseudogene is intronless, contains an in-frame stop codon following transmembrane-3, and has two one-nucleotide insertions between transmembrane-5 and -6 regions which alter the reading frame. The predicted amino acid sequence of the human pseudogene is about 35% identical with that of the rat serotonin-4 receptor.
Liu
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Department of Pharmacology, Faculty of Medicine, University of Toronto, Medical Science Building, 8 Taddle Creek Road, Toronto, Ontario M5S 1A8, Canada.
Kusumi
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Ulpian
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Tallerico
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Seeman
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D018388:Codon, Terminator; D004251:DNA Transposable Elements; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D007621:Karyotyping; D007962:Leukocytes / Q000378:metabolism; D008969:Molecular Sequence Data; D011544:Pseudogenes; D051381:Rats; D016364:Reading Frames; D011985:Receptors, Serotonin / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D044422:Receptors, Serotonin, 5-HT4; D015183:Restriction Mapping; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D018388:Codon, Terminator; D004251:DNA Transposable Elements; D011985:Receptors, Serotonin; D044422:Receptors, Serotonin, 5-HT4