The expression of urokinase type plasminogen activator is a novel prognostic factor in dukes B and C colorectal cancer.
Urokinase type plasminogen activator (u-PA) secreted by cancer cells is considered to play a key role in promoting invasion and metastasis of cancer cells. This study was designed to evaluate the expression and prognostic value of u-PA in Dukes B and C colorectal cancer. u-PA expression was investigated in 57 Dukes B or C colorectal cancers using a monoclonal antibody against u-PA. u-PA expression was mainly observed on the cytoplasm of cancer cells, and was associated with relapse, especially hematogenous metastasis (p=0.025, the chi2 test). Patients with high u-PA expression had a lower rate of DFS (9/22 events) compared to those with low u-PA expression (6/35 events) (p=0.061, log-rank test). This study demonstrated that u-PA expression might be a novel prognostic factor in Dukes B and C colorectal cancer.
Kim
S J
SJ
Department of Surgical Oncology, Osaka University, Medical School, 2-2 Yamadaoka, Suita City, Osaka 565, Japan.
Shiba
E
E
Tsukamoto
F
F
Izukura
M
M
Taguchi
T
T
Yoneda
K
K
Tanji
Y
Y
Kimoto
Y
Y
Takai
S I
SI
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000628:therapy; D012189:Retrospective Studies; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*
D016685:Mitomycin; D014568:Urokinase-Type Plasminogen Activator; D005472:Fluorouracil