title: Resection with curative intent after endoscopic treatment of airway obstruction.
abstract: BACKGROUND
  Endoscopic treatment of malignant central airway obstructions usually is done for palliation. The exact role of such a procedure as preparatory to operation remains controversial.
  
  
  METHODS
  From 1987 through 1996, 24 patients at our institution underwent tracheobronchial pulmonary resection after preliminary endoscopic treatment. During the same period, 304 patients underwent 449 operative rigid bronchoscopies for airway obstructions, most involving the use of a neodymium:yttrium-aluminum-garnet laser. The indications for operation were squamous cell carcinoma in 14 patients, bronchial gland tumors in 8 patients, and papillary thyroid cancer infiltrating the trachea in 2 patients. The total resection rate was 9.5% (5% for squamous cell carcinoma, 75% for low-grade malignant bronchial tumors, and 75% for papillary thyroid cancer). The median period between operative rigid bronchoscopy and operation was 18 days.
  
  
  RESULTS
  No complications were observed after endoscopic treatment. There were two perioperative deaths (adult respiratory distress syndrome after carinal resection and pulmonary embolism after pneumonectomy) and one major complication (poor postoperative pulmonary function after pneumonectomy). No anastomotic complications were observed in the tracheobronchoplastic procedures. Follow-up was possible in every patient but 1: 6 patients died at a median of 30.5 months after operation (range, 3 to 46 months), 2 patients are alive with disease, and the rest are alive without evidence of disease at a median of 21 months (range, 2 to 61 months).
  
  
  CONCLUSIONS
  Most patients who require endoscopic therapy for malignant airway obstructions are not candidates for operative resection. Preliminary endoscopic relief of obstruction can increase operability and improve surgical results in a highly selected group of patients.
authors.affiliation: Department of Surgery and General Thoracic Surgery, University of Perugia Medical School-Perugia, Terni, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Daddi
authors.forename: F
authors.initials: F
authors.lastname: Puma
authors.forename: N
authors.initials: N
authors.lastname: Avenia
authors.forename: S
authors.initials: S
authors.lastname: Santoprete
authors.forename: S
authors.initials: S
authors.lastname: Casadei
authors.forename: M
authors.initials: M
authors.lastname: Urbani
mesh_terms: D000328:Adult; D000368:Aged; D001984:Bronchial Neoplasms / Q000601:surgery / Q000628:therapy*; D001999:Bronchoscopy / Q000009:adverse effects; D002291:Carcinoma, Papillary / Q000601:surgery / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000601:surgery / Q000628:therapy*; D014134:Tracheal Neoplasms / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome