[Interactions of radiation factors and smoking in the etiology of lung cancer in workers of atomic enterprises].
It was shown on the basis of retrospective investigation of 500 workers at a nuclear enterprise (162 cases of lung cancer, 338 persons as matching control) that the interaction of external gamma-irradiation (> 2.0 Gy) and the body-burden of 239Pu (> 9.3 kBq) at lung cancer incidence in multiplicative. Combined influence of smoking and radiation factors was found dependent on smoking index (SI): it changed from additive up to multiplicative and than to antagonistic with the increase of the smoking effect. The received results could be explained on the basis of a two-mutation model of radiation carcinogenesis.
Tokarskaia
Z B
ZB
Branch No 1 of Scientific Research Center of Institute of Biophysics, Ozyorsk, Russia.
Khokhriakov
V F
VF
Okladnikova
N D
ND
Beliaeva
Z D
ZD
Zhuntova
G V
GV
D001822:Body Burden; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008962:Models, Theoretical; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009688:Nuclear Reactors; D009784:Occupational Diseases; D011005:Plutonium / Q000009:adverse effects*; D011829:Radiation Dosage; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects*
D011005:Plutonium
Vzaĭmodeĭstvie radiatsionnykh faktorov i kureniia pri razvitii raka legkogo u rabotnikov atomnogo predpriiatiia.