[Genotype and phenotype of apolipoprotein E in patients with Alzheimer's disease in Castille and Leon].
We determined the variants of the apolipoprotein E (apo-E) in a sample taken from a castellano-leonesa population with Alzheimer's disease (AD). The prevalence of the allele E-4 is 0.33 in AD and 0.12 in the control group. This results allow us to estimate that the risk of suffering from the disease is higher when the patients have an allele E-4. A significant correlation was found between the presence of the allele E4 and the AD (p < 0.005).
Cacho
J
J
Servicio de Neurología, Hospital Clínico Universitario, Salamanca.
Breñas
T
T
González
C
C
Arroyo
T
T
Arcaya
J
J
García
R
R
Guerrero
A L
AL
Navajo
J A
JA
García
C
C
González Buitrago
J M
JM
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics*; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D001057:Apolipoproteins E
Genotipo y fenotipo de la apolipoproteína E en enfermos de Alzheimer en Castilla y León.