[Bronchial reactivity in diabetic patients].
The data of the literature concerning bronchial reactivity in diabetic patients are controversial. Therefore, we studied the influence of the presence of a diabetic cardiac autonomic neuropathy (CAN) on the ventilatory parameters measured during a methacholine-induced bronchoconstriction test. Ten insulin-dependent diabetic patients without CAN, ten insulin-dependent diabetic patients with CAN and ten healthy volunteers, all non-smokers and free of respiratory symptoms, have undergone a functional respiratory check-up before the methacholine test. The presence of CAN was classically studied by the decrease in heart rate changes during three standardized tests (deep breathing at 6 cycles/min, Valsalva manoeuver, orthostatism) which all mainly explore the parasympathetic function. The bronchial response to methacholine was similar in the healthy subjects and in the diabetic patients without CAN. However, the fall in forced expiratory volume in 1 second induced by the highest dose of methacholine was significantly less marked in the diabetic subjects with CAN than in the two other groups. These results suggest that the diabetic autonomic neuropathy also involves the vagal innervation of the respiratory tract.
Pieron
M
M
Service de Diabétologie, Nutrition et Maladies métaboliques, CHU Sart Tilman, Liège, Belgique.
Scheen
A J
AJ
Corhay
J L
JL
Radermecker
M F
MF
Lefebvre
P J
PJ
D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D001980:Bronchi / Q000294:innervation* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D003627:Data Interpretation, Statistical; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D005541:Forced Expiratory Volume; D006321:Heart / Q000294:innervation; D006339:Heart Rate; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged; D011187:Posture; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000294:innervation; D014630:Vagus Nerve / Q000502:physiology; D014636:Valsalva Maneuver
D016210:Methacholine Chloride
Réactivité bronchique chez les patients diabétiques.