Advances from genetic clues in pancreatic cancer.
A major aim of cancer research is the construction of molecular genetic profiles that characterize each type of human neoplasm. Such a profile has recently achieved considerable resolution for pancreatic exocrine adenocarcinoma. Tools are now available to address the inheritance of risk, the nature of the precursor lesions, the challenges involved in the development of clinical screening approaches, and a deeper understanding of the malignant extreme of the neoplastic spectrum.
Kern
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Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology; D018450:Disease Progression; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D016296:Mutagenesis; D010183:Pancreatic Ducts / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D011230:Precancerous Conditions