title: The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.
abstract: The relationship between two methods of assessing tumour oxygenation in vivo, namely oxygen electrode measurement and magnetic resonance spectroscopy (MRS) of the fluorinated 2-nitroimidazole SR-4554, was investigated. Using three tumour models (two sites), no linear correlation was observed between 19F retention index and pO2 parameters (r < or = 0.3). Substantial retention of SR-4554 (19F retention index > 0.5) was, however, associated with low tumour pO2 (% pO2 < or = 5 mmHg = 60%). Depending on the pO2 parameters used, SR-4554 administration was shown to produce either a significant or a non-significant increase in tumour oxygenation. We conclude that measurement of SR-4554-related compound(s) by 19F-MRS has the potential to detect clinically relevant levels of tumour hypoxia.
authors.affiliation: CRC Department of Medical Oncology, Beatson Laboratories, Glasgow, UK.
authors.forename: E O
authors.initials: EO
authors.lastname: Aboagye
authors.forename: R J
authors.initials: RJ
authors.lastname: Maxwell
authors.forename: M R
authors.initials: MR
authors.lastname: Horsman
authors.forename: A D
authors.initials: AD
authors.lastname: Lewis
authors.forename: P
authors.initials: P
authors.lastname: Workman
authors.forename: M
authors.initials: M
authors.lastname: Tracy
authors.forename: J R
authors.initials: JR
authors.lastname: Griffiths
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000378:metabolism; D015687:Cell Hypoxia; D005462:Fluorine Radioisotopes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D015335:Molecular Probes / Q000737:chemistry; D009593:Nitroimidazoles / Q000737:chemistry; D010100:Oxygen / Q000378:metabolism*
chemical_list: D005462:Fluorine Radioisotopes; D015335:Molecular Probes; D009593:Nitroimidazoles; C095171:SR 4554; D010100:Oxygen