Immunosuppression by ultraviolet B rays via eyes in mice.
Irradiation by ultraviolet B (UV-B; 280-320 nm) initiates suppression of contact hypersensitivity. Immunosuppression was induced in C57BL/6N Crj mice by exposure of the dorsal skin or the eyes to a 10 kJ/m2 dose of UV-B radiation from 20SE sunlamps, followed by sensitization with 0.5% fluorescein isothiocyanate (FITC). The degree of immunosuppression induced by UV-B eye irradiation was equal to that induced by UV-B skin irradiation. When mice were irradiated with UV-B into the eyes after the optic nerve had been cut, systemic immunosuppression was not induced.
Hiramoto
K
K
Research Institute, Nippon Menard Cosmetic Co. Ltd., Nagoya, Japan.
Mashita
Y
Y
Katada
T
T
Konishi
H
H
Sugiura
M
M
Hayakawa
R
R
D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology*; D005123:Eye / Q000528:radiation effects*; D007165:Immunosuppression Therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009900:Optic Nerve / Q000502:physiology; D014466:Ultraviolet Rays