title: Heart transplantation with bicaval and pulmonary venous anastomoses. A hemodynamic analysis of the first 117 patients.
abstract: BACKGROUND
  A new surgical technique for orthotopic heart transplantation has been introduced into clinical practice. It accomplishes total atrioventricular transplantation as the recipient's atria are completely excised and the allograft is implanted using bicaval and pulmonary venous anastomoses.
  
  
  METHODS
  We retrospectively analyzed post-transplant hemodynamic and patient survival in our first 117 patients transplanted with this new operative approach and compared them with 64 patients transplanted with the standard biatrial technique.
  
  
  RESULTS
  Patients transplanted with the bicaval technique had a significantly lower right atrial mean, pulmonary arterial systolic, pulmonary arterial mean, and pulmonary capillary wedge pressures. In addition, a significant reduction in post-transplant tricuspid regurgitation and a trend towards less severe mitral regurgitation was observed. The need for permanent pacemaker implantation due to sinus node dysfunction after transplantation was completely eliminated with this new technique. Thirty-day operative survival and actuarial survival at 1, 2, 3, and 4 years was significantly greater in patients transplanted with the bicaval technique.
  
  
  CONCLUSIONS
  Orthotopic heart transplantation performed with bicaval and pulmonary venous anastomoses offers improved post-transplant hemodynamics, eliminates the need for permanent pacemaker, and has improved patient survival when compared with the standard biatrial technique. These differences can be related in part to improved hemodynamic function of the cardiac allograft due to preservation of the anatomic configuration and physiologic function of the atria.
authors.affiliation: Department of Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: C
authors.initials: C
authors.lastname: Blanche
authors.forename: S
authors.initials: S
authors.lastname: Nessim
authors.forename: A
authors.initials: A
authors.lastname: Quartel
authors.forename: J J
authors.initials: JJ
authors.lastname: Takkenberg
authors.forename: I
authors.initials: I
authors.lastname: Aleksic
authors.forename: M
authors.initials: M
authors.lastname: Cohen
authors.forename: L S
authors.initials: LS
authors.lastname: Czer
authors.forename: A
authors.initials: A
authors.lastname: Trento
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical; D005260:Female; D016027:Heart Transplantation / Q000379:methods* / Q000401:mortality / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins / Q000601:surgery; D012189:Retrospective Studies; D016019:Survival Analysis; D014184:Transplantation, Homologous; D014684:Venae Cavae / Q000601:surgery