title: Preneoplasia of the breast.
abstract: The present review emphasizes the pathology of premalignant ductal breast diseases, based on a three-cell concept of the breast. Immunohistochemical analyses using smooth-muscle actin, keratin 5/6, keratin 8/18/19 and MiB-1 proliferation antibodies demonstrated three different cell types in the normal breast: k 5/6 positive committed progenitor cells, k 8/18/19 positive glandular cells and smooth-muscle actin-positive myoepithelial cells. All hyperplastic lesions were shown to contain a mixture of those cells. According to their components, the hyperplastic lesions were subdivided into epithelial-myoepithelial, purely epithelial and myoepithelial lesions. All usual epithelial hyperplasias (= ductal hyperplasias) were composed of committed progenitor cells and glandular cells. On the contrary, ductal carcinoma in situ showed a monotonous cell pattern which, in the majority of cases, express k 8/18/19 and, in a minority (10-15%), k 5/6, signifying an unidirectional differentiation.
authors.affiliation: Gerhard-Domagk-Institut für Pathologie, Universität Münster.
authors.forename: W
authors.initials: W
authors.lastname: Böcker
mesh_terms: D034961:Antigens, Nuclear; D015415:Biomarkers / Q000032:analysis; D001941:Breast Diseases / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D019394:Ki-67 Antigen; D008954:Models, Biological; D009687:Nuclear Proteins / Q000032:analysis; D011230:Precancerous Conditions / Q000473:pathology*
chemical_list: D034961:Antigens, Nuclear; D015415:Biomarkers; D019394:Ki-67 Antigen; D009687:Nuclear Proteins