title: Projection of health benefits from ambient ozone reduction related to the use of methyl tertiary butyl ether (MTBE) in the reformulated gasoline program.
abstract: To estimate potential public health benefits from ozone (O3) pollution reduction attributable to the use of methyl tertiary-butyl ether (MTBE) in gasoline, O3 dose-response estimates from the biomedical literature were combined with model estimates of O3 reduction. Modeling employed EPA MOBILE5a and Complex models to predict emission changes, industry AQIRP techniques to predict ambient O3 changes, and the National Exposure Model to predict human exposures. Human health effects considered were lung function decrements and respiratory irritant symptoms (using dose-response functions measured in laboratory and field studies), and increased death rates (using concentration-response functions inferred statistically from public-health data). Other reported health effects, such as lung inflammation, increases in asthma attacks, and hospitalizations, were not addressed because of inadequate dose-response information. Even for the health responses considered, quantitation of improvements due to MTBE use is problematical, because MTBE affects only a small percentage of existing O3 pollution, and because exposure-response relationships are not well understood for population subgroups most likely to be affected. Nevertheless, it is reasonable to conclude that even small MTBE-associated reductions in peak ambient O3 levels (1-5 ppb, according to model estimates) should yield considerable public health benefits. Tens of millions of Americans are potentially exposed to O3 in the concentration range associated with health effects. Even if only a small percentage of them are susceptible, any incremental reduction in O3 (as with MTBE use) must mitigate or prevent effects for a meaningful number of people. Better quantitative estimates of benefit must await a more detailed understanding of each link in the chain of causation.
authors.affiliation: EA Engineering, Science and Technology, Inc., Bellevue, Washington 98004, USA.
authors.forename: S
authors.initials: S
authors.lastname: Erdal
authors.forename: H
authors.initials: H
authors.lastname: Gong
authors.forename: W S
authors.initials: WS
authors.lastname: Linn
authors.forename: R
authors.initials: R
authors.lastname: Rykowski
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects / Q000032:analysis*; D000397:Air Pollution / Q000517:prevention & control*; D001249:Asthma / Q000139:chemically induced / Q000503:physiopathology; D015984:Causality; D004198:Disease Susceptibility; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005544:Forecasting; D005742:Gasoline; D006760:Hospitalization; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008452:Maximum Allowable Concentration; D008738:Methyl Ethers / Q000737:chemistry*; D008956:Models, Chemical; D010083:Oxidants, Photochemical / Q000009:adverse effects / Q000032:analysis*; D010126:Ozone / Q000009:adverse effects / Q000032:analysis*; D011014:Pneumonia / Q000139:chemically induced; D011634:Public Health; D012119:Respiration / Q000187:drug effects; D012997:Solvents / Q000737:chemistry*; D015996:Survival Rate; D014481:United States; D014484:United States Environmental Protection Agency; D001335:Vehicle Emissions / Q000032:analysis
chemical_list: D000393:Air Pollutants; D005742:Gasoline; D007509:Irritants; D008738:Methyl Ethers; D010083:Oxidants, Photochemical; D012997:Solvents; D001335:Vehicle Emissions; C043243:methyl tert-butyl ether; D010126:Ozone