title: Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas.
abstract: Thirty-three eyes of 33 patients were prospectively evaluated to study the short term efficacy, safety, and overall surgical outcome of initial trabeculectomy for primary glaucomas with adjunctive intraoperative or postoperative 5-Fluorouracil (5-FU) use. Twelve eyes serving as controls underwent trabeculectomy without adjunctive antimetabolites. Eleven eyes received intraoperative 5-FU, while 10 eyes received subconjunctival 5-FU postoperatively. Intraocular pressure (IOP) was maintained below 22 mmHg at 3 months of follow up in 90.9% and 80% of patients in the intraoperative and postoperative 5-FU groups, respectively, without use of additional antiglaucoma medications, whereas 66.7% of the patients in the control group achieved similar IOP levels. Hypotony (IOP < 6 mmHg) was seen more commonly after intraoperative 5-FU (27.3%). Corneal epithelial defects were seen exclusively in the postoperative 5-FU group (40%). The use of intraoperative 5-FU exclusively as a mode of antimetabolites delivery seems an acceptable alternative to enhance success rates of trabeculectomy for the primary glaucomas.
authors.affiliation: Maulana Azad Medical College, New Delhi, India.
authors.forename: P A
authors.initials: PA
authors.lastname: Lamba
authors.forename: P K
authors.initials: PK
authors.lastname: Pandey
authors.forename: U K
authors.initials: UK
authors.lastname: Raina
authors.forename: V
authors.initials: V
authors.lastname: Krishna
mesh_terms: D000287:Administration, Topical; D000963:Antimetabolites / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011184:Postoperative Period; D012189:Retrospective Studies; D012449:Safety; D014130:Trabeculectomy / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000963:Antimetabolites; D009883:Ophthalmic Solutions; D005472:Fluorouracil