[The role of leukocytic infiltration in the development of neurogenic processes in the denervated rat cornea].
In early and late stages after different types of deafferentation of rat cornea extents of leukocyte infiltration and pathological changes are variable. Change of thickness of anterior epithelium and substantia propria, stratification of substantia propria fibres as well as epitheliocyte death and erosion occur only at late time intervals of deafferentation (after 1 d) when a large number of leukocytes appear in cornea. One day after the deafferentation performed following preliminary leukopoiesis suppression by irradiation, single leukocytes are encountered only in substantia propria of cornea while anterior epithelium thickness does not differ from that of intact animals, and the extent of pathological changes in substantia propria is reduced. These data demonstrate polymorphonuclear leukocyte participation in the development of neurogenic dystrophia in cornea.
Tolochko
Z S
ZS
Kniazeva
G B
GB
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002634:Chemotaxis, Leukocyte; D003315:Cornea / Q000294:innervation* / Q000473:pathology; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology; D003714:Denervation; D019573:Epithelium, Corneal / Q000294:innervation / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
Rol' leĭkotsitarnoĭ infil'tratsii v razvitii neĭrogennykh protsessov v denervirovannoĭ rogovitse krys.