Microbial biotransformation of veratramine.
Preparative-scale fermentation of the known C-nor-D-homosteroidal alkaloid veratramine (1) with Nocardia species ATCC 21145 has resulted in the isolation of three new metabolites, 2-4. The structure elucidation of these compounds was conducted primarily by 2D NMR analysis. The microbe Nocardia species ATCC 21145 was able to metabolize rings A and B of veratramine but failed to metabolize its nitrogen-containing side chain, an observation consistent with previous fermentation studies on steroidal alkaloids.
el Sayed
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Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677, USA. elsayed@olemiss.edu
D000818:Animals; D000962:Antimalarials / Q000378:metabolism* / Q000494:pharmacology; D001711:Biotransformation; D005658:Fungi / Q000378:metabolism; D009615:Nocardia / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000187:drug effects; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D014704:Veratrum Alkaloids / Q000378:metabolism* / Q000494:pharmacology
D000962:Antimalarials; D014704:Veratrum Alkaloids; C009649:veratramine