Drug discrimination analysis of pseudoephedrine in rats.
Rats were trained to discriminate amphetamine, 1 mg/kg given intraperitoneally, from saline injection in a two-lever operant drug discrimination task. Pseudoephedrine (a sympathomimetic drug with central and peripheral actions) at doses of 10 mg/kg failed to substitute for amphetamine, at 20 mg/kg partial substitution occurred, while at a 40 mg/kg full substitution was seen. The specificity of the amphetamine cue at the training dose used (1 mg/kg) was shown by the finding that a peripherally acting sympathomimetic drug phenylephrine at doses from 0.2 to 0.8 mg/kg failed to substitute for amphetamine. The potential for abuse of pseudoephedrine administered at high doses is discussed.
Tongjaroenbuangam
W
W
Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, Nakornpathom, Thailand.
Meksuriyen
D
D
Govitrapong
P
P
Kotchabhakdi
N
N
Baldwin
B A
BA
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003463:Cues; D004193:Discrimination Learning / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects*; D004809:Ephedrine / Q000494:pharmacology*; D005795:Generalization, Stimulus / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward
D000316:Adrenergic alpha-Agonists; D000697:Central Nervous System Stimulants; D000661:Amphetamine; D004809:Ephedrine