Experimental disseminated trichosporonosis in mice: tissue distribution and therapy with antifungal agents.
Mice treated with cyclophosphamide were infected intravenously with titrated doses of Trichosporon asahii TIMM3140 or TIMM3144. Mortality and survival time correlated with inoculum size and fungal growth was found in the lung, heart, liver, spleen, kidney and brain. Fluconazole and amphotericin B prolonged survival time and reduced the CFU in the kidney, with fluconazole being superior to amphotericin B. The serum level of (1-->3)-beta-D-glucan was reduced by antifungal therapy and correlated well with the CFU/organ in kidney, but not CFU/ml in blood.
Yamamoto
K
K
Teikyo University Institute of Medical Mycology, Tokyo, Japan. masa@kiwi.co.jp
Makimura
K
K
Sudo
T
T
Shibuya
K
K
Uchida
K
K
Yamaguchi
H
H
D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology / Q000473:pathology; D015169:Colony Count, Microbial; D003520:Cyclophosphamide; D004195:Disease Models, Animal; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use; D016469:Fungemia / Q000382:microbiology; D005936:Glucans / Q000097:blood; D006321:Heart / Q000382:microbiology; D007166:Immunosuppressive Agents; D007668:Kidney / Q000382:microbiology / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology* / Q000401:mortality; D009206:Myocardium / Q000473:pathology; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D014250:Trichosporon / Q000187:drug effects / Q000502:physiology*
D000935:Antifungal Agents; D005936:Glucans; D007166:Immunosuppressive Agents; D000666:Amphotericin B; D003520:Cyclophosphamide; D015725:Fluconazole