title: Transient cerebral arteriopathy: a disorder recognized by serial angiograms in children with stroke.
abstract: Repeated clinical evaluation and cerebral arteriography during the evolution of ischemic strokes of idiopathic origin allowed us to characterize a transient cerebral arteriopathy. We retrospectively studied the clinical characteristics, course, and neuroimaging features of this disorder in nine children. Of 34 children with ischemic strokes seen consecutively between 1984 and 1995, 9 (26%) were diagnosed as having transient attack of the cerebral arterial wall, termed transient cerebral arteriopathy. All of these patients had previously been in good health. The mean age at the time of the first stroke was 6 years (range, 2 9/12 years to 13 4/12 years). All children presented with acute hemiplegia. A recurrence of the stroke took place 3 months at the latest after the initial infarct in three children (mean clinical follow-up 2 7/12 years). Cerebral imaging in all the patients showed small subcortical infarcts located in basal ganglia or internal capsule. Arteriography revealed multifocal lesions of the arterial wall (focal stenosis or segmental narrowing), mostly located in the initial parts of basal arteries of the carotid system. Longitudinal arteriographic follow-up showed initial worsening of these arterial lesions (n = 5) for a maximum duration of 7 months followed by complete regression (n = 2), improvement (n = 5), or stabilization of the lesions (n = 2). Five patients had a complete clinical recovery. Further studies are necessary to confirm a presumed inflammatory cause of this arteriopathy.
authors.affiliation: Département de Pédiatrie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
authors.forename: S
authors.initials: S
authors.lastname: Chabrier
authors.forename: G
authors.initials: G
authors.lastname: Rodesch
authors.forename: P
authors.initials: P
authors.lastname: Lasjaunias
authors.forename: M
authors.initials: M
authors.lastname: Tardieu
authors.forename: P
authors.initials: P
authors.lastname: Landrieu
authors.forename: G
authors.initials: G
authors.lastname: Sébire
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002536:Cerebral Arteries / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications / Q000000981:diagnostic imaging* / Q000517:prevention & control; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011859:Radiography
chemical_list: D010975:Platelet Aggregation Inhibitors