[The effect of an isotonic solution of theophylline 300 on eosinophil cationic protein levels].
The aim of the study was to compare the influence of theophylline 300 on eosinophil cationic protein (ECP)level in serum in asthmatic patients Theophylline was given twice a day. Measurements of ECP in serum and lung function tests (PEF) were done before and at the first and fifth day after treatment Theophylline concentration were measured before and after treatment on the first injection and second injection at the first and the fifth day. ECP in serum was measured by radioimmunosorbent assay using ECP RIA kit Pharmacia. Concentration of theophylline by Emit Theophylline Assay Syva Company. The lung function test (PEF) were measured with Wright Peak flowmeter


RESULTS
ECP level had decreased in serum 37 + 15 micrograms/l before vs 30 + 12 micrograms/l on the first day and 17 + 9 micrograms/l on the fifth day of observation Lung function tests had improved during the observation.
Chazan
R
R
Katedry i Kliniki Chorób Wewnetrznych i Pneumonologii.
Grubek-Jaworska
H
H
Boros
M M
MM
Chazan-Polanowska
E
E
Droszcz
W
W
D000328:Adult; D001249:Asthma / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D001798:Blood Proteins / Q000032:analysis / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D012129:Respiratory Function Tests; D012260:Ribonucleases; D013806:Theophylline / Q000494:pharmacology / Q000627:therapeutic use*
D001798:Blood Proteins; D001993:Bronchodilator Agents; D047091:Eosinophil Granule Proteins; D013806:Theophylline; D012260:Ribonucleases
Wpływ izotonicznego roztworu teofilinum 300 na stezenie eozynofilowego białka kationowego.