title: Dural sinus thrombosis associated with activated protein C resistance: MR imaging findings and proband identification.
abstract: OBJECTIVE
  The purpose of this study was to report the association of dural sinus thrombosis with a hypercoagulable state associated with activated protein C resistance.
  
  
  CONCLUSIONS
  In our small study population, hemorrhagic venous infarction was common (three of four patients) among patients with dural sinus thrombosis and activated protein C resistance. Four of five patients with dural sinus thrombosis had positive tests for activated protein C resistance. This finding, in conjunction with data from other studies, suggests that patients with dural sinus thrombosis may need to be studied for the presence of activated protein C resistance. A positive finding for activated protein C resistance can be important not only in helping to explain the cause of thrombosis in affected individuals but also in identifying families at risk for thrombosis.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC 27710-3808, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Provenzale
authors.forename: D P
authors.initials: DP
authors.lastname: Barboriak
authors.forename: T L
authors.initials: TL
authors.lastname: Ortel
mesh_terms: D000328:Adult; D004388:Dura Mater; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011486:Protein C / Q000502:physiology*; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000097:blood / Q000235:genetics* / Q000473:pathology*
chemical_list: D011486:Protein C