Concordance and contradiction concerning cytokines and chemokines in experimental demyelinating disease.
Experimental autoimmune encephalomyelitis (EAE) has served as a model for human demyelinating diseases, including multiple sclerosis. EAE is mediated by CD4+ T lymphocytes of the TH1 subset. These T cells produce inflammatory cytokines and chemokines that are associated with pathogenicity. The disease is downregulated by other T cells, presumably of the TH2 subset that secrete a different pattern of cytokines which modulate the activity of the pathogenic TH1 cells. Ongoing studies should provide insight into how the interactions of T-cell subsets impact on the pathogenesis of autoimmune demyelinating diseases.
Smeltz
R B
RB
Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Swanborg
R H
RH
D000818:Animals; D018925:Chemokines / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D003711:Demyelinating Diseases / Q000503:physiopathology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology / Q000503:physiopathology; D006801:Humans
D018925:Chemokines; D016207:Cytokines