title: A prospective study of the effect of fundoplication on primary and secondary peristalsis in the esophagus.
abstract: We studied 13 patients before and after Nissen fundoplication and compared them with 11 healthy volunteers and 12 other patients with dysphagia after fundoplication. Esophageal manometry was performed to assess primary and secondary peristalsis induced by esophageal distention with air and water boluses. In patients with reflux disease, secondary peristalsis was initiated at a median rate of 60% of distending episodes, propagation of the secondary peristaltic wave occurred in 40% and lower oesophageal sphincter relaxation occurred with 70% of secondary peristaltic waves. Fundoplication did not alter the initiation or propagation rate of secondary peristalsis but it decreased the median lower esophageal sphincter relaxation rate to 45% (P < 0.03). Fundoplication was not associated with a change in the amplitude of primary peristaltic waves even in patients complaining of dysphagia. In post-fundoplication patients, successful secondary peristaltic waves had significantly lower (P < 0.005) proximal and distal amplitude than primary peristaltic waves. We conclude that there is no improvement in primary or secondary peristalsis after fundoplication and dysphagia after fundoplication is not due to altered peristalsis.
authors.affiliation: Department of Surgery, Royal Adelaide Hospital, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Tew
authors.forename: G G
authors.initials: GG
authors.lastname: Jamieson
authors.forename: R H
authors.initials: RH
authors.lastname: Holloway
authors.forename: S
authors.initials: S
authors.lastname: Ferguson
authors.forename: P
authors.initials: P
authors.lastname: Tew
mesh_terms: D000328:Adult; D000368:Aged; D000388:Air; D000704:Analysis of Variance; D016022:Case-Control Studies; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology; D004106:Dilatation; D004942:Esophagitis, Peptic / Q000503:physiopathology; D004943:Esophagogastric Junction / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D018662:Fundoplication / Q000009:adverse effects; D005764:Gastroesophageal Reflux / Q000503:physiopathology; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009126:Muscle Relaxation / Q000502:physiology; D010528:Peristalsis / Q000502:physiology; D011446:Prospective Studies; D014867:Water
chemical_list: D014867:Water