title: A relationship between fluctuations in heart rate and the duration of subsequent episodes of atrial fibrillation.
abstract: A relationship between autonomic tone and the onset of paroxysmal atrial fibrillation in some patients is recognised. Episodes of PAF may vary enormously in duration, however, from a few beats to many hours. Whether autonomic tone influences the duration of the episodes has been less well investigated. From a database of Holter recording taken from patients with symptomatic PAF, we identified all episodes of at least 30 seconds duration which were preceded by noise free sinus rhythm. This study examined the heart rate prior to AF onset, the change in heart rate over the final minute of sinus rhythm and the time of AF onset, and compared the data from those episodes of AF of more than 5 minutes duration to the shorter ones. Heart rate was slower before long episodes of AF, but this was found to predominantly represent data from separate recordings. A highly significant rise in heart rate was detected prior to long AF episodes compared to shorter ones. Daytime AF episodes were slightly longer than nocturnal ones. The most important finding was that longer AF episodes were typified by a heart rate acceleration. This suggests that, regardless of underlying aetiology, and increase in sympathetic tone may be important in the sustenance of episodes of PAF.
authors.affiliation: Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Hnatkova
authors.forename: J E
authors.initials: JE
authors.lastname: Waktare
authors.forename: S M
authors.initials: SM
authors.lastname: Sopher
authors.forename: F D
authors.initials: FD
authors.lastname: Murgatroyd
authors.forename: X
authors.initials: X
authors.lastname: Baiyan
authors.forename: A J
authors.initials: AJ
authors.lastname: Camm
authors.forename: M
authors.initials: M
authors.lastname: Malik
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000889:Anti-Arrhythmia Agents