Hyperammonemic encephalopathy after chemotherapy. Survival after treatment with sodium benzoate and sodium phenylacetate.
A 16-year-old boy had hyperammonemia and encephalopathy develop after high-dose chemotherapy for acute lymphoblastic leukemia. He was treated successfully with the ammonia-trapping agents sodium benzoate and sodium phenylacetate.
del Rosario
M
M
Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA.
Werlin
S L
SL
Lauer
S J
SJ
D000293:Adolescent; D000641:Ammonia / Q000097:blood*; D000963:Antimetabolites / Q000627:therapeutic use*; D001565:Benzoates / Q000627:therapeutic use*; D019817:Benzoic Acid; D001927:Brain Diseases / Q000139:chemically induced / Q000188:drug therapy*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008297:Male; D010648:Phenylacetates / Q000627:therapeutic use*
D000963:Antimetabolites; D001565:Benzoates; D010648:Phenylacetates; D000641:Ammonia; D019817:Benzoic Acid; C025136:phenylacetic acid