Dual determination of angiotensin-converting enzyme and angiotensin-II type 1 receptor genotypes as predictors of restenosis after coronary angioplasty.
This study sought to assess the potential influence of the angiotensin-converting enzyme (ACE) and angiotensin II type 1 (AT1) receptor gene polymorphisms on restenosis after coronary balloon angioplasty. The authors conclude that screening for genetic suspectibility to restenosis based on genotyping of ACE and AT1 receptor polymorphisms before conventional balloon angioplasty is not clinically useful.
Hamon
M
M
University and Center Hospitalier Régional Universitaire, Lille, France.
Amant
C
C
Bauters
C
C
Richard
F
F
Helbecque
N
N
Passard
F
F
McFadden
E P
EP
Lablanche
J M
JM
Bertrand
M E
ME
Amouyel
P
P
D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000235:genetics* / Q000378:metabolism / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D017353:Gene Deletion; D005787:Gene Frequency; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000097:blood*; D012008:Recurrence
D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin; D007703:Peptidyl-Dipeptidase A