Lack of carcinogenicity of thiamphenicol in F344 rats.
The carcinogenicity of thiamphenicol (TAP), an antibiotic drug, was examined in Fischer 344 rats of both sexes. TAP was given ad lib. in drinking water at levels of 0 (control), 125 or 250 ppm to groups of 50 male and 50 female rats for 2 yr. The treatment did not affect mortality and no toxic lesions were specifically induced. Furthermore, the incidence of tumours in the treated groups did not show any significant dose-related increase as compared with the control group. The results thus indicate that TAP is neither toxic nor carcinogenic, for any organs or tissues of F344 rats when given continuously at levels of 125 or 250 ppm in drinking water for 2 yr.
Kitamura
T
T
Department of Pathology, Sasaki Institute, Tokyo, Japan.
Ando
J
J
Ishihara
R
R
Takano
S
S
Iijima
T
T
Nishimura
S
S
Yoshida
M
M
Takahashi
M
M
Maekawa
A
A
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D015197:Carcinogenicity Tests; D002701:Chloramphenicol / Q000737:chemistry; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D009369:Neoplasms / Q000139:chemically induced / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D016019:Survival Analysis; D013839:Thiamphenicol / Q000737:chemistry / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D013839:Thiamphenicol