[The mechanisms of ulcerogenesis in liver pathology in persons exposed to the action of ionizing radiation].
A total of 92 patients with duodenal ulcer (DU) who took part in the elimination of aftereffects of Chernobyl accident in 1986 were examined. Of these, 46 patients (group I) developed DU against the background of persisting hepatitis. The above patients demonstrated significant increase in the peripheral blood levels of hemoglobin and red cell count as well as immunoglobulins of all classes and circulating immune complexes in blood serum. By far the commonest among group I patients (compared to group II) were such events as allergization of the organism and duodenogastric reflux. Based on the studies made a conclusion is drawn to the effect that it is necessary that specific agents capable of improving hemodynamics, endowed with immunocorrective and antiallergic activity should be included into a complex of therapeutic measures designed to treat those patients with hepatitis having been exposed to ionizing radiation, together with those means capable of normalizing the pyloroduodenal portion motor-and-evacuatory function to prevent the DU development.
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D000328:Adult; D000917:Antibody Formation / Q000528:radiation effects; D006801:Humans; D007111:Immunity, Cellular / Q000528:radiation effects; D008107:Liver Diseases / Q000097:blood / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000150:complications* / Q000276:immunology; D010437:Peptic Ulcer / Q000097:blood / Q000209:etiology* / Q000276:immunology; D011210:Power Plants; D011832:Radiation Injuries / Q000097:blood / Q000150:complications* / Q000276:immunology; D018788:Radioactive Hazard Release; D013997:Time Factors; D014455:Ukraine
Deiaki mekhanizmy ul'tserohenezu pry patolohiï pechinky u osib, iaki zaznaly diï ionizuiuchoho vyprominiuvannia.