The effectiveness of intrauterine insemination in couples with sterility due to male infertility with and without a woman's hormone factor.
OBJECTIVE
To examine the efficacy of IUI on fecundity and baby-take-home rates in cases of infertility attributable to a male factor with and without a woman's hormone factor.


METHODS
Retrospective analysis.


METHODS
Department of Gynecology and Obstetrics at the General Public Hospital, Horn, Austria.


METHODS
Seventy-eight long-standing involuntarily childless couples.


METHODS
After a follicular phase GnRH analog (buserelin) protocol with hMG stimulation of the woman and a Percoll gradient preparation and capacitation of the man's semen, an IUI was performed.


METHODS
Fecundity and baby-take-home rates.


RESULTS
One hundred nine inseminations were followed by 53 pregnancies (48.6%; 95% confidence intervals (CI) 38.9%-58.4%) and 38 deliveries (34.9%; 95% CI 26.0%-44.6%). Forty-nine children were born and 47 are alive (43.1%).


CONCLUSIONS
Intrauterine insemination combined with buserelin gonadotropin stimulation, Percoll semen preparation, and sperm capacitation is a feasible solution to the problem of sterility attributable to a male factor with and without a woman's hormone factor.
Rammer
E
E
Department of Gynecology and Obstetrics, General Public Hospital, Horn, Austria.
Friedrich
F
F
D000293:Adolescent; D000328:Adult; D001723:Birth Rate; D002064:Buserelin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007248:Infertility, Male / Q000628:therapy*; D007317:Insemination, Artificial, Homologous; D008297:Male; D008596:Menotropins / Q000627:therapeutic use; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013075:Sperm Capacitation / Q000502:physiology
D008596:Menotropins; D002064:Buserelin