title: Effects of cholecystokinin-B receptor antagonist on dopamine system in tenascin mutant mice.
abstract: The aim of this study was to investigate the effect of cholecystokinin (CCK) receptor antagonist on the abnormal behavior and dopamine (DA) transmission of tenascin (TN)-gene knockout mice. Recently, we demonstrated that TN-gene deficient mice show hyperlocomotion that is related to reduced DA transmission and tyrosine hydroxylase (TH) activities in the brain. In this report, we show that the intraperitoneal administration of a CCK-B receptor antagonist, PD135158 (0.1 mg/kg), but not a CCK-A receptor antagonist, lorglumide, inhibited hyperlocomotion. Moreover, PD135158 reversed the low levels of DA turnover rate and TH activities in the striatum of TN-gene knockout mouse brain. These results suggest that CCK-B receptor is involved in the behavior of TN-gene knockout mouse through striatal DA transmission.
authors.affiliation: Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Fukamauchi
authors.forename: Y J
authors.initials: YJ
authors.lastname: Wang
authors.forename: N
authors.initials: N
authors.lastname: Mataga
authors.forename: M
authors.initials: M
authors.lastname: Kusakabe
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D006948:Hyperkinesis / Q000235:genetics; D007211:Indoles / Q000494:pharmacology*; D008536:Meglumine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D009435:Synaptic Transmission / Q000187:drug effects*; D019063:Tenascin / Q000633:toxicity*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D007211:Indoles; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; D019063:Tenascin; D015102:3,4-Dihydroxyphenylacetic Acid; C065600:PD 135158; D008536:Meglumine; D014446:Tyrosine 3-Monooxygenase; D011377:Proglumide; C048181:lorglumide; D004298:Dopamine