title: Neuropsychological performance in low birth weight preschoolers: a population-based, controlled study.
abstract: The aim was to evaluate neuropsychological performance and its pre-, and perinatal predictors in low birth weight (LBW) preschool children. A population-based sample of 137 5-year-old children with birth weights less than 2000 g and without major handicaps was compared with a random sample of 152 normal birth weight term controls. Main assessment tools were all subscales from the Wechsler Preschool and Primary Scale of Intelligence Revised, subscales from the Illinois Test of Psycholinguistic Abilities and tests of manual dexterity and figure copying. The LBW children showed significantly lower mean scores compared to controls on tests of visuo-spatial and visuo-motor abilities, but were comparable to controls in other areas, confounding parental factors were controlled for. 14 of the LBW children, there were signs of maternal chorio-amnionitis. Twelve of these had premature rupture of membranes lasting more than 24 h. These 14 children had a mean performance IQ of 87 (SD 5) compared to 100 (SD 15) for the LBW children without maternal signs of chorio-amnionitis (P = 0.001). Having a small head circumference at birth was a less powerful, but statistically significant predictor of impaired performance.
  
  
  CONCLUSIONS
  Low birth weight is associated with impaired performance on visuo-spatial and visuo-motor tasks. Signs of maternal chorio-amnionitis and a small head circumference at birth may be risk factors for such impairment.
authors.affiliation: Department of Paediatrics, Barneklinikken, Haukeland Sykehus, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Sommerfelt
authors.forename: T
authors.initials: T
authors.lastname: Markestad
authors.forename: B
authors.initials: B
authors.lastname: Ellertsen
mesh_terms: D016022:Case-Control Studies; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D002821:Chorioamnionitis / Q000453:epidemiology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D009048:Motor Skills; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D009483:Neuropsychological Tests; D009664:Norway / Q000453:epidemiology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011597:Psychomotor Performance; D012044:Regression Analysis; D012307:Risk Factors; D012494:Sampling Studies