Transcriptional regulation in the immune system: all roads lead to AP-1.
The mechanisms regulating the development and function of the immune system are diverse and complicated. The signaling pathways and target genes that become activated upon cell-surface stimulation are currently being defined, and transcription factor activator protein 1 (AP-1) is proving to be an important regulator of nuclear gene expression in leukocytes. In vitro and in vivo studies have demonstrated that AP-1 expression is induced after a diverse range of stimuli and that AP-1 contributes to the regulation of a large number of genes. In this review we will examine the role of AP-1 during leukocyte activation and differentiation in the immune system.
Foletta
V C
VC
Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4068, USA. torie@codon.nih.gov
Segal
D H
DH
Cohen
D R
DR
D000818:Animals; D000917:Antibody Formation; D017209:Apoptosis; D001402:B-Lymphocytes / Q000502:physiology*; D002454:Cell Differentiation; D016207:Cytokines / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008213:Lymphocyte Activation; D011485:Protein Binding; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology; D018808:Transcription Factor AP-1 / Q000502:physiology*; D014158:Transcription, Genetic
D016207:Cytokines; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D018808:Transcription Factor AP-1