Cutaneous lesions in patients with visceral leishmaniasis and HIV infection.
Cutaneous lesions attributed to Leishmania are very seldom observed in classic Kala-Azar, but recently some reports have mentioned them in patients with HIV infection. We found cutaneous lesions whose biopsy disclosed the presence of Leishmania organisms in six patients of a group of 32 HIV patients with visceral Leishmaniasis. These lesions did not present a uniform or specific appearance, even though they tended to localize symmetrically on acral zones. They consisted of erythematous papules and hypopigmented macules on the dorsa of the hands, feet, and elbows; small subcutaneous nodules on the thighs; and erythematoviolaceous, scaly plaques on the face. These lesions accompanied in every case the other symptoms and/or signs of visceral leishmaniasis, responded to anti-leishmanial treatment, and were sometimes the first indicator of recurrence. The histopathological study was non-specific, but showed in every case the presence of abundant amastigotes within the dermal histiocytes and free in the dermis or subcutaneous tissue. Data from literature review are similar to ours.
Postigo
C
C
Servicio de Dermatologia, Hospital 1 2 de Octubre, Madrid, Spain.
Llamas
R
R
Zarco
C
C
Rubio
R
R
Pulido
F
F
Costa
J R
JR
Iglesias
L
L
D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D001706:Biopsy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006801:Humans; D018314:Leishmania infantum / Q000276:immunology / Q000302:isolation & purification*; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000473:pathology*; D008297:Male; D012867:Skin / Q000469:parasitology / Q000473:pathology*
D000913:Antibodies, Protozoan