title: A close correlation between c-erbB-2 gene amplification and local progression in endometrial adenocarcinoma.
abstract: The c-erbB-2 proto-oncogene is a gene that encodes a growth factor receptor-like molecule with tyrosine kinase activity. The purpose of this study was to determine whether c-erbB-2 gene amplification measured by the simple and sensitive differential polymerase chain reaction (PCR) method correlates with clinicopathological factors in endometrial adenocarcinomas. Overall, 7 out of the 38 endometrial adenocarcinomas (18.4%) displayed amplified c-erbB-2 oncogene. No correlation between c-erbB-2 gene amplification and FIGO stage, histologic grade or existence of metastatic disease was found. There was a significant association between c-erbB-2 gene amplification and deep myometrial invasion. In the current study, it has been suggested that c-erbB-2 gene amplification is possibly involved in local progression but is not closely related to the loss of cell differentiation and metastasis.
authors.affiliation: Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Seki
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: J
authors.initials: J
authors.lastname: Kodama
authors.forename: Y
authors.initials: Y
authors.lastname: Miyagi
authors.forename: M
authors.initials: M
authors.lastname: Yoshinouchi
authors.forename: T
authors.initials: T
authors.lastname: Kudo
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000175:diagnosis*; D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000175:diagnosis*; D005260:Female; D005784:Gene Amplification; D006801:Humans; D016133:Polymerase Chain Reaction; D000090063:Proto-Oncogene Mas; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*
chemical_list: D000090063:Proto-Oncogene Mas; D018719:Erb-b2 Receptor Tyrosine Kinases; C000715470:MAS1 protein, human