title: Hyperammonemic encephalopathy after chemotherapy. Survival after treatment with sodium benzoate and sodium phenylacetate.
abstract: A 16-year-old boy had hyperammonemia and encephalopathy develop after high-dose chemotherapy for acute lymphoblastic leukemia. He was treated successfully with the ammonia-trapping agents sodium benzoate and sodium phenylacetate.
authors.affiliation: Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226, USA.
authors.forename: M
authors.initials: M
authors.lastname: del Rosario
authors.forename: S L
authors.initials: SL
authors.lastname: Werlin
authors.forename: S J
authors.initials: SJ
authors.lastname: Lauer
mesh_terms: D000293:Adolescent; D000641:Ammonia / Q000097:blood*; D000963:Antimetabolites / Q000627:therapeutic use*; D001565:Benzoates / Q000627:therapeutic use*; D019817:Benzoic Acid; D001927:Brain Diseases / Q000139:chemically induced / Q000188:drug therapy*; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008297:Male; D010648:Phenylacetates / Q000627:therapeutic use*
chemical_list: D000963:Antimetabolites; D001565:Benzoates; D010648:Phenylacetates; D000641:Ammonia; D019817:Benzoic Acid; C025136:phenylacetic acid