title: Rare case of autoimmune hyperchylomicronemia during pregnancy.
abstract: A pregnant woman was found to have severe hypertriglyceridemia, fasting chylomicronemia, and low platelet count. The activities of serum lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) proved to be extremely low. The activities of the enzymes in normal plasma were completely inhibited by addition of the patient's plasma. We concluded that autoantibodies to lipases were responsible for this patient's hypertriglyceridemia.
authors.affiliation: Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Japan. yoshimur@kaiju.medic.kumamoto-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Yoshimura
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Sakoda
authors.forename: S
authors.initials: S
authors.lastname: Kobori
authors.forename: H
authors.initials: H
authors.lastname: Okamura
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases; D002914:Chylomicrons / Q000097:blood*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000276:immunology; D008049:Lipase / Q000172:deficiency / Q000276:immunology; D008071:Lipoprotein Lipase / Q000172:deficiency / Q000276:immunology; D008099:Liver / Q000201:enzymology; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D013921:Thrombocytopenia / Q000276:immunology
chemical_list: D001323:Autoantibodies; D002914:Chylomicrons; D008049:Lipase; D008071:Lipoprotein Lipase