title: Rate of decline in renal function in Indo-Asians and Whites with diabetic nephropathy.
abstract: The incidence of end-stage renal failure (ESRF) is higher in the Indo-Asian ethnic group as compared to the White. To investigate whether this might be associated with faster rates of progression to ESRF in Indo-Asian diabetic patients, we studied a total of 39 Type 2 diabetic patients, using the Department of Nephrology database showing serial serum creatinine measurements from the time of first referral to the clinic until they reached a level of >500 micromol l(-1) or ESRF requiring renal replacement therapy (RRT), either dialysis or renal transplantation. They were grouped into Indo-Asian (n = 24) and White (n = 15). The rate of progression of those who developed ESRF, calculated as the slope of log serum creatinine against time, was not significantly different between the Indo-Asian and White patients, p = 0.73. We conclude that the higher incidence of ESRF in the Indo-Asian Type 2 diabetic patient with nephropathy is therefore not due to a faster rate of deterioration in renal function.
authors.affiliation: Department of Diabetic Medicine, Leicester General Hospital, UK.
authors.forename: N
authors.initials: N
authors.lastname: Koppiker
authors.forename: J
authors.initials: J
authors.lastname: Feehally
authors.forename: N
authors.initials: N
authors.lastname: Raymond
authors.forename: K R
authors.initials: KR
authors.lastname: Abrams
authors.forename: A C
authors.initials: AC
authors.lastname: Burden
mesh_terms: D000328:Adult; D000368:Aged; D001208:Asia / Q000208:ethnology; D003928:Diabetic Nephropathies / Q000150:complications / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D006113:United Kingdom / Q000453:epidemiology; D044465:White People