Efficacy of diethylcarbamazine-medicated salt for microfilaraemia of Brugia malayi.
BACKGROUND
Pilot studies in India and abroad have demonstrated the benefit of cooking salt fortified with diethylcarbamazine citrate (DEC) for the control of lymphatic filariasis. In India, DEC-medicated salt has been introduced on a commercial basis in the Cherthala region of Kerala, which is endemic for Brugia malayi (B. malayi). We studied the efficacy of DEC-medicated salt in the clearance of microfilaraemia of B. malayi.


METHODS
Eighteen cases of microfilaraemia (11 men; 7 women) were selected; 14 in the experimental group (i.e. treated with 0.2% w/w DEC-medicated salt) and the rest as the control group who were given a placebo. The consumption of salt and the status of parasitaemia were monitored till all the microfilaria carriers became negative.


RESULTS
There was a significant reduction in the density of microfilariae (intensity) among the treated individuals over a period of time. The duration required for the clearance of microfilariae ranged from 9 to 30 [mean (SD) 19.4 (1.7)] weeks. All microfilaraemics except one reported side-effects which were mild-to-moderate and persisted for a maximum period of one month.


CONCLUSIONS
DEC-medicated salt effectively clears microfilariae within 30 weeks in parasitaemic individuals. No 'endemic normals' reported any side-effects, though these were common among the microfilaria carriers.
Panicker
K N
KN
Vector Control Research Centre, Pondicherry, India.
Arunachalam
N
N
Kumar
N P
NP
Prathibha
J
J
Sabesan
S
S
D000818:Animals; D017178:Brugia malayi; D016022:Case-Control Studies; D004049:Diethylcarbamazine / Q000627:therapeutic use*; D004605:Elephantiasis, Filarial / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D005369:Filaricides / Q000627:therapeutic use*; D006801:Humans; D007194:India; D016018:Least-Squares Analysis; D008297:Male; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage
D005369:Filaricides; D017673:Sodium Chloride, Dietary; D004049:Diethylcarbamazine