Vasomotility and nitric oxide bioactivity of the bridging segments of the left anterior descending coronary artery.
We compared bridging and nonbridging coronary artery segments with respect to the vasoconstrictor effect of acetylcholine. Bridging segments were hypersensitive to the constrictor effect of acetylcholine, and results suggest that the effect of nitric oxide on the acetylcholine-stimulated condition is decreased, or that the smooth muscle sensitivity to acetylcholine is increased.
Shiode
N
N
The First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Kato
M
M
Teragawa
H
H
Yamada
T
T
Hirao
H
H
Nomura
K
K
Sasaki
N
N
Yamagata
T
T
Matsuura
H
H
Kajiyama
G
G
D000109:Acetylcholine / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D003251:Constriction, Pathologic; D003331:Coronary Vessels / Q000473:pathology*; D004730:Endothelium, Vascular / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005996:Nitroglycerin / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*; D014666:Vasomotor System / Q000187:drug effects*; D019323:omega-N-Methylarginine / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D014665:Vasodilator Agents; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D005996:Nitroglycerin; D000109:Acetylcholine