Synovial fluid levels of fluconazole in a patient with Candida parapsilosis prosthetic joint infection who had an excellent clinical response.
A 73-year-old woman presenting with persistent swelling of the right knee 30 months after total joint arthroplasty was found to have a Candida parapsilosis infection. Treatment with fluconazole resulted in full recovery.
Cushing
R D
RD
Bon Secours Hospital, Grosse Pointe, Michigan 48230, USA.
Fulgenzi
W R
WR
D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint; D007720:Knee Prosthesis / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013582:Synovial Fluid / Q000378:metabolism* / Q000382:microbiology
D000935:Antifungal Agents; D015725:Fluconazole