[Inhibitors of calcium-calmodulin system and hypothalamic sex differentiation in rats. Biochemical parameters].
The systemic action of certain psychotropic drugs (haloperidol, penfluridol, trifluoperazine pimozide and verapamil) inhibitors of calcium-calmodulin-system, some biochemical and morphological parameters during the sexual differentiation of hypothalamus in neonatal (72 hours) male and androgenized female rats were studied. The hypothalamic weight in normal adult rats of both sexes not changed (39.7 +/- 3.79 vs 40.57 +/- 7.60 mg); however, verapamil increased the hypothalamic weight (table II), haloperidol and pimozide were the most effective (1.50 +/- 0.49 g and 2.00 +/- 0.11 g respectively). The testosterone administered to newborn females decreased the ovary development (46.3 +/- 4.5 mg. vs 23.1 +/- 2.7 mg), the haloperidol and pimozide partially reverted this effect.
Canchola-Martínez
E
E
Departamento de Biología de la Reproducción, UAM-Iztapalapa, México, D.F. Cancho@xanum.uam.mx
Vergara-Onofre
M
M
Rodríguez-Medina
M A
MA
Mercado-Sánchez
G
G
D000818:Animals; D000831:Animals, Newborn; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D004247:DNA / Q000378:metabolism; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009929:Organ Size; D010053:Ovary / Q000187:drug effects; D010395:Penfluridol / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D012733:Sex Differentiation / Q000187:drug effects*; D013737:Testis / Q000187:drug effects; D014268:Trifluoperazine / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D014150:Antipsychotic Agents; D002121:Calcium Channel Blockers; D002147:Calmodulin; D018492:Dopamine Antagonists; D011506:Proteins; D010868:Pimozide; D014268:Trifluoperazine; D010395:Penfluridol; D012313:RNA; D004247:DNA; D014700:Verapamil; D006220:Haloperidol
Inhibidores del sistema calcio-Calmodulina y diferenciación sexual hipotalámica en la rata. Parámetros bioquímicos.