title: Induction chemotherapy and radiotherapy to avoid mastectomy in stage IIA-IIIA breast cancer.
abstract: The aim of the presented protocol was to investigate tumour remission and breast conservation rates with and without flap supported surgery after preoperative chemotherapy, radiotherapy and hyperthermia. 101 patients with stage IIA-IIIA breast cancers were initially treated with chemotherapy, radiotherapy and hyperthermia. 96 patients underwent salvage surgery. Complete pathologic response was not related to tumour diameter at diagnosis, the applied chemotherapy regime, number of chemotherapy cycles, overall radiation treatment time and time interval between radiotherapy and surgery. A breast conserving approach was possible in 55 patients (54%). After a median follow-up of 18 months no patient developed an isolated local recurrence.
authors.affiliation: Academic Medical Center, University of Amsterdam, Department of Radiotherapy, P.O. Box 22700, DE Amsterdam, 1100, The Netherlands.
authors.forename: K A
authors.initials: KA
authors.lastname: Hartmann
authors.forename: I
authors.initials: I
authors.lastname: Waap
authors.forename: W
authors.initials: W
authors.lastname: Audretsch
authors.forename: K
authors.initials: K
authors.lastname: Muskalla
authors.forename: M
authors.initials: M
authors.lastname: Rezai
authors.forename: J
authors.initials: J
authors.lastname: von der Haar
authors.forename: G
authors.initials: G
authors.lastname: Schmitt
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001918:Brachytherapy; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D007496:Iridium Radioisotopes