Results of histo-pathologic examination of three enucleated eyes with a choroidal melanoma after strontium-90 irradiation.
Three patients with a choroidal melanoma, treated with HDR (High Dose Rate) Strontium-90 brachytherapy, underwent an enucleation. Radiation effect was only visible at the irradiation zone with a brisk transition to normal tissue. Tumour was replaced by necrotic and scar tissue. The underlying sclera had a markedly reduced number of fibrocytes, but no structural alteration of the collagen stroma.
Parys-van Ginderdeuren
R
R
Department Ophthalmology, Katholieke Universiteit Leuven.
van den Oord
J J
JJ
Missotten
L
L
D000368:Aged; D001918:Brachytherapy; D002452:Cell Count / Q000528:radiation effects; D002829:Choroid / Q000473:pathology / Q000528:radiation effects; D002830:Choroid Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D002921:Cicatrix / Q000473:pathology; D003094:Collagen / Q000528:radiation effects / Q000648:ultrastructure; D015353:Eye Enucleation; D005260:Female; D005347:Fibroblasts / Q000473:pathology / Q000528:radiation effects; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D009336:Necrosis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D012590:Sclera / Q000473:pathology / Q000528:radiation effects; D013326:Strontium Radioisotopes / Q000627:therapeutic use*
D019275:Radiopharmaceuticals; D013326:Strontium Radioisotopes; D003094:Collagen