title: Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
abstract: Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.
authors.affiliation: Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS-CEA/CNRS/Université Joseph Fourier, Grenoble, France. Fontecav@cbcrb.ceng.cea.fr
authors.forename: M
authors.initials: M
authors.lastname: Fontecave
authors.forename: M
authors.initials: M
authors.lastname: Lepoivre
authors.forename: E
authors.initials: E
authors.lastname: Elleingand
authors.forename: C
authors.initials: C
authors.lastname: Gerez
authors.forename: O
authors.initials: O
authors.lastname: Guittet
mesh_terms: D000818:Animals; D004273:DNA, Neoplasm; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005609:Free Radicals; D006801:Humans; D051379:Mice; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology*; D011993:Recombinant Fusion Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D000077185:Resveratrol; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors* / Q000235:genetics; D013267:Stilbenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D004791:Enzyme Inhibitors; D005609:Free Radicals; D019384:Nucleic Acid Synthesis Inhibitors; D011993:Recombinant Fusion Proteins; D013267:Stilbenes; D014443:Tyrosine; D012264:Ribonucleotide Reductases; C108427:ribonucleotide reductase R2 subunit; D000077185:Resveratrol