Loss of heterozygosity at loci from chromosome arm 22Q in human sporadic breast carcinomas.
Forty-four breast carcinomas were studied for loss of heterozygosity (LOH) at 25 microsatellite markers distributed almost evenly along chromosome arm 22q. LOH at at least one marker were observed in 66% tumors, while 6 regions of consistent LOH were identified. The size of each region ranged between 3 and 6 cM, and the distance between each region was estimated to be 8 to 12 cM. Even if not all these regions contain a bona fide tumor-suppressor gene, it is possible that several loci from chromosome arm 22q may be involved in breast carcinogenesis.
Allione
F
F
Laboratoire de Biologie des Tumeurs, Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France.
Eisinger
F
F
Parc
P
P
Noguchi
T
T
Sobol
H
H
Birnbaum
D
D
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D008875:Middle Aged