Evaluation of early second trimester maternal serum creatine kinase isoenzyme BB as a marker of poor pregnancy outcome.
We hypothesized that maternal serum levels of the isoenzyme creatine kinase (CK)-BB, which is highly expressed in the placenta, may be elevated during the early second trimester in gestations destined to deliver prematurely or of a small-for-gestational-age infant (birthweight below 10th percentile). To test this hypothesis, we compared maternal serum CK-BB levels and percentage of CK-BB over total CK, in 69 normal pregnancies (delivering at term of appropriate-for-gestational-age infants) with those of 25 cases complicated by preterm delivery at < or = 34 weeks (n = 14), of a small-for-gestational-age infant (n = 8), or both (n = 3). No differences were present in maternal serum CK BB levels between normal and complicated pregnancies. Moreover, no correlation was found between gestational age at delivery and CK BB levels (r = 0.03; p = 0.7).
Jenkins
C B
CB
Department of Obstetrics and Gynecology, Georgetown University Medical Center, Washington, DC 20007, USA.
Ghidini
A
A
Spong
C Y
CY
Eglinton
G S
GS
Pezzullo
J C
JC
Michejda
M
M
D000328:Adult; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007527:Isoenzymes; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second
D015415:Biomarkers; D007527:Isoenzymes; D003402:Creatine Kinase