[Human herpesvirus 6 and 7 infections].
HHV-6 was first isolated in 1986 from patients with lymphoproliferative disorders and was classified into 2 variants such as HHV-6A and HHV-6B. It was reported that HHV-6B is the causative agent of exanthem subitum (ES). Children start to be infected with HHV-6 at 6 month of age and almost all get antibody by 2 years old. HHV-6 infects latently after the primary infection and reactivates especially under the immunosuppressive condition. HHV-7 was first isolated in 1990 and the HHV-7 infection occurs later than HHV-6. Children get HHV-7 infection mostly inapparently, but HHV-7 also cause ES. Since HHV-6 has several genes which transactivate long terminal repeat (LTR) of HIV, it is proposed that HHV-6 may have a role as the cofactor for AIDS.
Mori
Y
Y
Department of Microbiology, Osaka University Medical School.
Yamanishi
K
K
D000163:Acquired Immunodeficiency Syndrome / Q000821:virology; D002648:Child; D002675:Child, Preschool; D005077:Exanthema Subitum / Q000821:virology; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000635:transmission / Q000821:virology; D015654:Herpesvirus 6, Human / Q000302:isolation & purification / Q000472:pathogenicity; D016199:Herpesvirus 7, Human / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D014775:Virus Activation; D017735:Virus Latency