Sex-specific modifiers of tail development in mice heterozygous for the brachyury (T) mutation.
The brachyury, or T, locus encodes a transcription factor that plays a crucial role in the early development of all animals. In the mouse, animals heterozygous for a null mutation at this locus are born with a characteristic short tail. Expressivity of the short tail phenotype is greatly affected by genetic background. As a genetic entry into the identification of genes that interact with the Brachyury locus, we have performed a QTL analysis for modifiers of this phenotype. Surprisingly, we discovered that the major modifiers uncovered all act in a sex-limited manner. We have identified two QTLs--Brm1 on Chr 9 and Brm2 on Chr 15--that act only in female offspring(N2) from female T/+ parents(F1) and are responsible together for most, or all, of the genetic variance in phenotypic expression observed between C57BL/10 and C3H/HeJ animals.
Agulnik
I I
II
Department of Molecular Biology, Princeton University, New Jersey 08544-1014, USA.
Agulnik
S I
SI
Saatkamp
B D
BD
Silver
L M
LM
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005326:Fetal Proteins; D018507:Gene Expression Regulation, Developmental; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D008297:Male; D051379:Mice; D018895:Microsatellite Repeats; D009154:Mutation; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D012727:Sex Characteristics; D020825:T-Box Domain Proteins; D013623:Tail / Q000196:embryology*; D014157:Transcription Factors / Q000235:genetics*; D000098908:Brachyury Protein
D004268:DNA-Binding Proteins; D005326:Fetal Proteins; D005819:Genetic Markers; D020825:T-Box Domain Proteins; D014157:Transcription Factors; D000098908:Brachyury Protein