title: Effects of cisapride on QTc interval in neonates.
abstract: OBJECTIVE
  Prospective survey of the effects of cisapride on QTc interval in neonates given cisapride.
  
  
  METHODS
  QTc interval was determined just before and 2.9 (0.9) days after outset of the treatment in 49 neonates treated with cisapride between 1 August 1995 and 29 February 1996.
  
  
  RESULTS
  Cisapride significantly increased QTc interval (p = 0.0001), and this was higher when birthweight or gestational age were lower. The prolongation of QTc interval above the arbitrary value of 0.450 (n = 7) was clinically asymptomatic and was significantly more common in the infants born with a gestational age < or = 33 weeks (n = 6).
  
  
  CONCLUSIONS
  The findings indicate that cisapride accumulates in less mature neonates. Further pharmacokinetic studies are needed.
authors.affiliation: Centre Hospitalier Universitaire, Dijon, France.
authors.forename: S
authors.initials: S
authors.lastname: Bernardini
authors.forename: D S
authors.initials: DS
authors.lastname: Semama
authors.forename: F
authors.initials: F
authors.lastname: Huet
authors.forename: C
authors.initials: C
authors.lastname: Sgro
authors.forename: J B
authors.initials: JB
authors.lastname: Gouyon
mesh_terms: D020117:Cisapride; D004562:Electrocardiography / Q000187:drug effects*; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D011446:Prospective Studies; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride