title: Enrichment for loci identical-by-descent between pairs of mouse or human genomes by genomic mismatch scanning.
abstract: Mapping genes that underlie complex genetic traits, including genes that determine susceptibility to common diseases, requires an efficient method for high-resolution genotyping. Single-nucleotide differences between pairs of allelic sequences from unrelated individuals occur approximately once in every kilobase. Genomic mismatch scanning (GMS), by analyzing numerous single-nucleotide polymorphisms in a single genome-wide step, offers a potentially powerful and efficient approach to linkage analysis. GMS, originally developed in a yeast system, is shown here to be applicable to the more complex mouse and human genomes.
authors.affiliation: Division of Cardiovascular Medicine, Stanford University Medical Center, California 94305-5307, USA.
authors.forename: L
authors.initials: L
authors.lastname: McAllister
authors.forename: L
authors.initials: L
authors.lastname: Penland
authors.forename: P O
authors.initials: PO
authors.lastname: Brown
mesh_terms: D000251:Adenosine Triphosphatases; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods*; D003433:Crosses, Genetic; D029968:Escherichia coli Proteins; D005260:Female; D005821:Genetic Techniques; D015894:Genome, Human; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018895:Microsatellite Repeats; D000070956:MutL Proteins; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C074770:MutL protein, E coli; D000251:Adenosine Triphosphatases; D000070956:MutL Proteins