title: Evidence for biotype-specific effects of bovine viral diarrhoea virus on biological responses in acutely infected calves.
abstract: The relationship between the two biotypes of bovine viral diarrhoea virus (BVDV) and the biological responses they induce was studied in 3- to 6-month-old calves inoculated intranasally with a homologous pair of non-cytopathic and cytopathic strains. Marked differences in virological and serological events occurred following exposure to a specific BVDV strain. The non-cytopathic biotype was frequently recovered from nasal secretions and blood cells during the first 28 days post-inoculation whereas the cytopathic counterpart was detected infrequently in nasopharyngeal swabs only. There was no correlation of the recovery of infectious virus in vivo with the biotype-specific neutralizing humoral immune response. Furthermore, seroconversion did not correlate with resistance to reinfection as judged by the transient viraemia and/or shedding of virus observed in a challenge experiment.
authors.affiliation: Department of Immunology/Vaccinology, Faculty of Veterinary Medicine, University of Liège, Belgium. Lambot@stat.fmv.ulg.ac.be
authors.forename: M
authors.initials: M
authors.lastname: Lambot
authors.forename: E
authors.initials: E
authors.lastname: Joris
authors.forename: A
authors.initials: A
authors.lastname: Douart
authors.forename: J
authors.initials: J
authors.lastname: Lyaku
authors.forename: J J
authors.initials: JJ
authors.lastname: Letesson
authors.forename: P P
authors.initials: PP
authors.lastname: Pastoret
mesh_terms: D000208:Acute Disease; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology* / Q000517:prevention & control / Q000821:virology*; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000145:classification / Q000276:immunology / Q000502:physiology*
chemical_list: D000914:Antibodies, Viral