title: Development and evaluation of totally implantable ventricular assist system using a vibrating flow pump and transcutaneous energy transmission system with amorphous fibers.
abstract: We have developed a vibrating flow pump (VFP) that can generate oscillated blood flow with a relatively high frequency (10-50 Hz) for a totally implantable ventricular assist system (VAS). To evaluate the newly developed VAS, left heart bypasses, using the VFP, were performed in chronic animal experiments. Hemodynamic parameters were recorded in a data recorder in healthy adult goats during an awake condition and analyzed in a personal computer system through an alternating-direct current converter. Basic performance of the total system with a transcutaneous energy transmission system were satisfactory. During left ventricular assistance with the VFP, Mayer wave fluctuations of hemodynamics were decreased in the power spectrum, the fractal dimensions of the hemodynamics were significantly decreased, and peripheral vascular resistance was significantly decreased. These results suggest that cardiovascular regulatory nonlinear dynamics, which mediate the hemodynamics, may be affected by left ventricular bypass with oscillated flow. The decreased power of the Mayer wave in the spectrum caused the limit cycle attractor of the hemodynamics and decreased peripheral resistance. These results suggest that this newly developed VAS is useful for the totally implantable system with unique characteristics that can control hemodynamic properties.
authors.affiliation: Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yambe
authors.forename: H
authors.initials: H
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Sonobe
authors.forename: S
authors.initials: S
authors.lastname: Naganuma
authors.forename: S S
authors.initials: SS
authors.lastname: Nanka
authors.forename: H
authors.initials: H
authors.lastname: Matsuki
authors.forename: M
authors.initials: M
authors.lastname: Yoshizawa
authors.forename: K
authors.initials: K
authors.lastname: Tabayashi
authors.forename: H
authors.initials: H
authors.lastname: Takayasu
authors.forename: H
authors.initials: H
authors.lastname: Takeda
authors.forename: S
authors.initials: S
authors.lastname: Nitta
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000502:physiology; D055590:Electromagnetic Phenomena; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D017709:Fractals; D006041:Goats; D018611:Heart Bypass, Left; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology; D008955:Models, Cardiovascular; D017711:Nonlinear Dynamics; D014732:Vibration