Interaction of angiotensin II and adenosine receptors in pentylenetetrazol-induced kindling in mice.
The relationships of adenosine A1 receptor agonists and antagonists in combination with angiotensin II (AT II) and its analogue sarmesin in PTZ (pentylenetetrazol) kindling in ICR mice were studied. The occurrence of clonic and tonic seizures and the latency to their onset in PTZ kindled mice was determined. Combination of adenosinergic and AT II-ergic agents significantly reduced the incidence of clonic seizures in PTZ kindling without changing the latency. Pretreatment with 8-p-Sulfophenyl-theophylline (8-p-SPT) reversed the anti-convulsant effect of sarmesin.
Georgiev
V P
VP
Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia. georgiev@iph.bio.acad.bg
Tchekalarova
J D
JD
D000704:Analysis of Variance; D000804:Angiotensin II / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D003292:Convulsants; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced; D007696:Kindling, Neurologic; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010433:Pentylenetetrazole; D011930:Reaction Time / Q000187:drug effects; D018047:Receptors, Purinergic P1 / Q000187:drug effects*
D003292:Convulsants; D018047:Receptors, Purinergic P1; D000804:Angiotensin II; C040420:angiotensin II, Sar(1)-Me-Tyr(4)-; D010433:Pentylenetetrazole