title: Quality of life after proctocolectomy and ileo-anal anastomosis for severe ulcerative colitis.
abstract: OBJECTIVE
  Impaired quality of life (QOL) in patients with ulcerative colitis (UC) may be a prominent feature of the disease, and in some cases, may become an indication for surgical treatment. The objective of this study was to assess QOL in patients who underwent proctocolectomy with ileo-anal anastomosis with a J pouch for severe UC and to compare it with patients with UC of different severity who were under medical treatment.
  
  
  METHODS
  We used a validated, disease-specific research instrument (a 29 item, self-administered questionnaire) that examines the following four functions: intestinal (score 0-24) and systemic symptoms (0-21), and emotional (0-27) and Social Function (0-15). High scores indicate an impairment of the function examined and the sum of the four scores (maximal total score = 87) reflects the patient's QOL. We studied 29 operated patients (22 men, mean age 35 yr, mean time after intervention 3.8 yr) and compared their scores with those of 57 UC patients (39 men, mean age 36 yr) with different degrees of disease activity, and with those of 72 healthy controls (38 men, mean age 31 yr).
  
  
  RESULTS
  In UC, scores were significantly higher than in controls, increasing with the severity of the disease. Even patients in remission had higher scores than controls in the "systemic" (4.6 vs. 2.0) and emotional (5.6 vs. 2.5) functions. Patients who underwent surgical treatment had much better scores than patients with severe disease (total score 20.1 vs. 38.2), with values comparable to those of patients in remission or with mild disease activity. There was no significant gender difference, either for UC and ileo-anal anastomosis patients, or in healthy controls.
  
  
  CONCLUSIONS
  In patients with UC, even in remission, there is a measurable impairment of QOL, which increases with the severity of disease. Operated patients have a QOL that is comparable to that of patients in remission or with mild disease, and proctocolectomy with ileo-anal anastomosis may restore an acceptable QOL in patients with moderate/severe UC.
authors.affiliation: Divisione di Gastroenterologia e Clinica Chirurgica I, Università degli Studi di Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Dinca
authors.forename: L
authors.initials: L
authors.lastname: Leone
authors.forename: W
authors.initials: W
authors.lastname: Fries
authors.forename: I
authors.initials: I
authors.lastname: Angriman
authors.forename: A
authors.initials: A
authors.lastname: Tropea
authors.forename: R
authors.initials: R
authors.lastname: Naccarato
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000523:psychology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D017060:Patient Satisfaction; D016737:Proctocolectomy, Restorative; D011788:Quality of Life; D011795:Surveys and Questionnaires