[Effects of cystamine on the state of glutathione system].
The action of cystamine on the glutathione system state in the erythrocytes of the peripheral blood, in the tissues of the brain and liver of the rats are studied. It was shown that the most changes in the glutathione content and activity of the glutathione metabolism enzymes are seen in the brain on the height of the cystamine protective action. The high concentration of reduced forms of the glutathione and the increasing activity of the glutathione peroxidase held in the liver for 5-th days after the intraperitoneal injection of the cystamine.
Grebeniuk
A N
AN
Military Medical Academy, St. Petersburg.
Udintsev
A V
AV
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D003538:Cystamine / Q000008:administration & dosage / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D011837:Radiation-Protective Agents; D005979:Glutathione Peroxidase; D005978:Glutathione; D003538:Cystamine
Vliianie tsistamina na sostoianie sistemy glutationa.