The genetics of schizophrenia: past, present, and future concepts.
Although a genetic susceptibility for schizophrenia has been long established and even noted by Kraepelin in 1907, the mechanisms for its inheritance remains unknown. No candidates have proven to be correct and while many weakly positive chromosomal linkages have been reported, none have yet been consistently replicated. The following review examines the present status of these findings. The conclusion is that the field must move on to finding a consistently replicable mutation segregating with schizophrenia in families, before any of the present linkage results can be resolved.
DeLisi
L E
LE
State University of New York at Stony Brook, Health Sciences Center, 11794, USA. ldelisi@ccmail.sunysb.edu
D002874:Chromosome Mapping; D004198:Disease Susceptibility; D008040:Genetic Linkage; D005819:Genetic Markers; D005826:Genetics, Medical / Q000639:trends*; D006801:Humans; D011570:Psychiatry / Q000639:trends*; D012559:Schizophrenia / Q000235:genetics*; D014960:X Chromosome / Q000235:genetics
D005819:Genetic Markers