title: Separation of enantiomers of drugs by capillary electrophoresis. V. Hydroxypropyl-alpha-cyclodextrin as chiral solvating agent.
abstract: In an extended chiral drug screening program, enantioseparation of 86 racemic drugs was tested with hydroxypropyl-alpha-cyclodextrin as chiral solvating agent (CSA). A total of 34 drugs out of 86 could be resolved in this straightforward approach. The number of experiments performed under identical conditions allows a correlation of the separation factors alpha(m) with the interaction strengths Rm. As shown for a subset of 23 drugs, the concentration of the CSA is a crucial parameter for further optimization.
authors.affiliation: Institute for Organic Chemistry, University of Tübingen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Koppenhoefer
authors.forename: U
authors.initials: U
authors.lastname: Epperlein
authors.forename: R
authors.initials: R
authors.lastname: Schlunk
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: B
authors.initials: B
authors.lastname: Lin
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D013237:Stereoisomerism; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D004364:Pharmaceutical Preparations; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; C479658:hydroxypropyl-alpha-cyclodextrin; D000073738:2-Hydroxypropyl-beta-cyclodextrin