The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick.
Recently, we have reported that central administration of glucagon-like peptide-1 (GLP-1) strongly decreases food intake of chicks. The aim of this study was to elucidate whether suppressed food intake induced by the central injection of GLP-1 is mediated by activation of the hypothalamic-pituitary-adrenal axis. First, the effects of central administration of corticotropin-releasing factor (CRF) were investigated. Birds (2-day-old) were food-deprived for 3 h and then CRF or saline was injected intracerebroventricular (i.c.v.). CRF strongly inhibited food intake. Thereafter, effects of central CRF or GLP-1 on plasma corticosterone concentration were examined. CRF significantly stimulated corticosterone release, but GLP-1 did not alter plasma corticosterone concentration. These results suggest that CRF is a potent inhibitor of food intake in the chick, but the suppression of food intake induced by central GLP-1 may not be involved in the activation of hypothalamic-pituitary-adrenal axis.
Furuse
M
M
Laboratory of Animal Feed Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan. furuse@agr.kyushu-u.ac.jp
Matsumoto
M
M
Saito
N
N
Sugahara
K
K
Hasegawa
S
S
D000818:Animals; D000831:Animals, Newborn; D002645:Chickens; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011498:Protein Precursors / Q000008:administration & dosage / Q000494:pharmacology*
D010446:Peptide Fragments; D011498:Protein Precursors; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone