title: Effect of some Sitavirya drugs on gastric secretion and ulceration.
abstract: Four Sitavirya plants viz. Satavari (fresh root juice, 1250 mg/kg), Yastimadhu (water decoction of root, 600 mg/kg), Kutaja and Aswattha (water decoctions of bark; 400 and 500 mg/kg respectively) were studied for their effects on different models of gastroduodenal ulcers in rats, when given orally for 3 days. All of them were found to protect the animals against 2 hr cold restraint stress and pylorus ligation-induced gastric and cysteamine-induced duodenal ulcers. However, they were ineffective against acute aspirin-induced gastric ulcers. The antiulcerogenic effect could be due to their inhibitory effect on offensive acid-pepsin secretion and augmentation of mucosal defensive factors in terms of enhanced mucin secretion and decreased cell shedding.
authors.affiliation: Department of Dravyaguna, Banaras Hindu University, Varanasi, India.
authors.forename: B
authors.initials: B
authors.lastname: De
authors.forename: R N
authors.initials: RN
authors.lastname: Maiti
authors.forename: V K
authors.initials: VK
authors.lastname: Joshi
authors.forename: V K
authors.initials: VK
authors.lastname: Agrawal
authors.forename: R K
authors.initials: RK
authors.lastname: Goel
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010437:Peptic Ulcer / Q000188:drug therapy*; D010946:Plants, Medicinal; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D000897:Anti-Ulcer Agents