Protein phosphorylation and dephosphorylation in physiologic and oncologic processes.
Phosphorylation and dephosphorylation of proteins is an important regulatory mechanism of cell metabolism, proliferation and differentiation. The present review summarizes the known key players, their interactions, effects on physiological processes, and their role in pathology and neoplasia.
Patarca
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Department of Medicine, E. M. Papper Laboratory of Clinical Immunology, University of Miami School of Medicine, FL 33160, USA.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011506:Proteins / Q000378:metabolism*
D015513:Oncogene Proteins; D011506:Proteins; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D017027:Protein Tyrosine Phosphatases