[The role of active oxygen radicals in blood system reactions in inflammation].
On the model of carrageenan-induced acute aseptic peritonitis in rats with using of alpha-tocopherol it is shown that the active oxygen metabolites increase granulomonocytopoiesis, leukocytosis and stimulation of blood neutrophils, accumulation and activation of neutrophils of an inflammatory focus, decrease accumulation and stimulation of monocytes of an inflammatory focus and thus they are pro-inflammatory modulators of the blood system's reactions.
Klymenko
M O
MO
Shevchenko
O M
OM
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism*; D002351:Carrageenan; D004195:Disease Models, Animal; D008297:Male; D010538:Peritonitis / Q000097:blood* / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013997:Time Factors; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D014810:Vitamin E; D002351:Carrageenan; D024502:alpha-Tocopherol; D024505:Tocopherols
Rol' aktyvnykh radykaliv kysniu v reaktsiiakh systemy krovi pry zapalenni.