CD8 cell noncytotoxic antiviral activity in human immunodeficiency virus-infected and -uninfected children.
CD8 cells from human immunodeficiency virus (HIV)-infected adults and children can show cytotoxic as well as noncytotoxic activity against viral replication. The noncytotoxic anti-HIV response, measured by suppression of acute viral infection of CD4 cells, has also been observed in uninfected adults who have a history of exposure to HIV. This CD8 cell antiviral activity was found to be detectable as well in approximately 50% of uninfected children born of infected mothers. The findings could reflect a protective response of the children to HIV after being exposed to the virus.
Levy
J A
JA
Cancer Research Institute, Department of Medicine, University of California, San Francisco, 94143-1270, USA.
Hsueh
F
F
Blackbourn
D J
DJ
Wara
D
D
Weintrub
P S
PS
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D002675:Child, Preschool; D005260:Female; D015483:HIV Antibodies / Q000032:analysis / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control; D018023:HIV Seronegativity; D006801:Humans; D007111:Immunity, Cellular; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology
D015483:HIV Antibodies