title: Multiparametric analysis of heart rate variability used for risk stratification among survivors of acute myocardial infarction.
abstract: A multiparametric heart rate variability analysis was performed to prove if combined heart rate variability (HRV) measures of different domains improve the result of risk stratification in patients after myocardial infarction. In this study, standard time domain, frequency domain and non-linear dynamics measures of HRV assessment were applied to 572 survivors of acute myocardial infarction. Three parameter sets each consisting of 4 parameters were applied and compared with the standard measurement of global heart rate variability HRVi. Discriminant analysis technique and t-test were performed to separate the high risk groups from the survivors. The predictive value of this approach was evaluated with receiver operator (ROC) and positive predictive accuracy (PPA) curves. Results--The discriminant analysis shows a separation of patients suffered by all cause mortality in 80% (best single parameter 74%) and sudden arrhythmic death in 86% (73%). All parameters of set 1 show a high significant difference (p < 0.001) between survivors and non-survivors based on two-tailed t-test. The specificity level of the multivariate parameter sets is at the 70% sensitivity level (ROC) about 85-90%, whereas HRVi shows maximum levels of 70%. The PPA in the all cause mortality group is at the 70% sensitivity level twice as high as the univariate HRV measure and increases to more than fourfold as high within the VT/VF group. In conclusion, in this population, the multiparametric approach with the combination of four parameters from all domains especially from NLD seems to be a better predictor of high arrhythmia risk than the standard measurement of global heart rate variability.
authors.affiliation: University of Applied Sciences Jena, Germany. voss@fh-jena.de
authors.forename: A
authors.initials: A
authors.lastname: Voss
authors.forename: K
authors.initials: K
authors.lastname: Hnatkova
authors.forename: N
authors.initials: N
authors.lastname: Wessel
authors.forename: J
authors.initials: J
authors.lastname: Kurths
authors.forename: A
authors.initials: A
authors.lastname: Sander
authors.forename: A
authors.initials: A
authors.lastname: Schirdewan
authors.forename: A J
authors.initials: AJ
authors.lastname: Camm
authors.forename: M
authors.initials: M
authors.lastname: Malik
mesh_terms: D001145:Arrhythmias, Cardiac / Q000453:epidemiology*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology*; D015716:Electrocardiography, Ambulatory; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology*; D017711:Nonlinear Dynamics; D011237:Predictive Value of Tests; D012372:ROC Curve; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted