Randomized trial of neomycin/dexamethasone spray vs drop preparation for the treatment of active chronic mucosal otitis media.
Active mucosal chronic otitis media (COM) is notoriously difficult to treat. A randomized, non-blind trial of a drop vs spray preparation of neomycin sulphate (3250 units/ml) and dexamethasone 0.1% (Otomize) has been performed. The spray was significantly better than drops (91% vs 44%) in the resolution of activity in simple perforations (P = 0.002 chi 2 test, with continuity correction). In ears with an open mastoid cavity, 68% of those on the spray preparation became inactive compared with 42% on drops, a difference which just failed to achieve statistical significance (P = 0.06). It is concluded that the spray delivery system is a significant improvement over drops for the treatment of active mucosal COM particularly in the absence of a mastoid cavity.
Connolly
A A
AA
Department of Otolaryngology, St Michael's Hospital, Bristol, UK.
Picozzi
G L
GL
Browning
G G
GG
D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002908:Chronic Disease; D003907:Dexamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D010035:Otitis Media, Suppurative / Q000188:drug therapy*; D012996:Solutions
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; C071179:Otomize; D012996:Solutions; D003907:Dexamethasone; D009355:Neomycin