Detection of human herpesvirus-8 DNA in oral ulcer tissues of HIV-infected individuals.
OBJECTIVE
To determine the frequency of detection of human herpesvirus-8 (HHV-8) in HIV-related oral ulcers.


METHODS
Analysis of archived biopsy material.


METHODS
Nested polymerase chain reaction of DNA extracts.


RESULTS
HHV-8 DNA was detected in six of 10 oral ulcers of HIV-positive patients without oral Kaposi's sarcoma (KS) lesions and five of 11 oral KS lesions. The positive non-KS samples were derived from various oral sites.


CONCLUSIONS
In HIV-positive people, HHV-8 can infect oral tissues that are not affected by KS.
Di Alberti
L
L
Department of Oral Medicine, Eastman Dental Institute, London, UK.
Porter
S R
SR
Speight
P M
PM
Scully
C M
CM
Zakrzewska
J M
JM
Williams
I G
IG
Artese
L
L
Piattelli
A
A
Ngui
S L
SL
Teo
C G
CG
D017088:AIDS-Related Opportunistic Infections / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis*; D015658:HIV Infections / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D009061:Mouth Mucosa / Q000821:virology; D019226:Oral Ulcer / Q000821:virology*; D012514:Sarcoma, Kaposi / Q000821:virology
D004279:DNA, Viral