[Molecular biology of human herpesvirus 6: DNA replication and trans-activator genes].
HHV-6 genes and their functions that are unique and different from those of HCMV are summarized. HHV-6 encodes a HSV-1 UL9 homolog that is an origin-binding protein (OBP) essential for HSV-1 DNA replication, although HCMV has no clear homolog. The HHV-6 OBP binds to sequences with similarity to alpha-herpesvirus replication origin that lie within a genomic segment serving as an origin in transient assays. Consensus sequence for OBP binding, protein domain analyses and a model for OBP-origin interactions are described. HHV-6 encodes an AAV-2 rep homolog. Its transcript is expressed at low mRNA levels as a spliced transcript. The gene product suppresses both transformation by H.ras and transcription by HIV-1 promoters. HHV-6 specific transactivator gene DR7 exhibits malignant transforming activity and its protein binds to p53. Studies on IE-A locus and an HCMV UL69 homolog are also discussed.
Inoue
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Dept. Medicine, Univ. Washington.
D001483:Base Sequence; D004261:DNA Replication; D004279:DNA, Viral; D004268:DNA-Binding Proteins / Q000502:physiology; D005814:Genes, Viral / Q000502:physiology*; D015654:Herpesvirus 6, Human / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D015534:Trans-Activators / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology; D014779:Virus Replication
D004279:DNA, Viral; D004268:DNA-Binding Proteins; D015534:Trans-Activators; D014764:Viral Proteins; C055789:origin-binding proteins, viral