[The characteristics of the lymphocyte subpopulation composition and its clinical significance in bacterial carriers of toxigenic Corynebacterium diphtheriae].
In 43 carriers of toxigenic C. diphtheriae the antigenic picture of lymphocyte membranes was studied by the method of flow cytofluorometry. The study revealed that at the time of the hospitalization of the carriers a decrease in the number of CD21+ and HDL-DR+ lymphocytes was a prognostically important criterion for the formation of carrier state, while a decrease in the content of natural killers (CD16+) was characteristic of prolonged forms of carrier state. The necessity of the study of cellular immunity factors in carriers at the time of their hospitalization and the expediency of the inclusion of immunocorrective therapy into the individual schemes of their treatment were substantiated.
Iushchuk
N D
ND
Medical Stomatological Institute, Moscow, Russia.
Eremina
O F
OF
Ostroukhova
M V
MV
Novikova
T A
TA
Tumanova
R B
RB
Petina
G K
GK
D000328:Adult; D015703:Antigens, CD / Q000097:blood; D002353:Carrier State / Q000276:immunology*; D002908:Chronic Disease; D004165:Diphtheria / Q000276:immunology*; D004167:Diphtheria Toxin; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D007111:Immunity, Cellular; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male
D015703:Antigens, CD; D004167:Diphtheria Toxin; D006684:HLA-DR Antigens
Kharakteristika subpopuliatsionnogo sostava limfotsitov i ego klinicheskoe znachenie u bakterionositeleĭ toksigennykh Corynebacterium diphtheriae.