title: Changes in auxin response from mutations in an AUX/IAA gene.
abstract: Transcription of the AUX/IAA family of genes is rapidly induced by the plant hormone auxin, but evidence that AUX/IAA genes mediate further responses to auxin has been elusive. Changes in diverse auxin responses result from mutations in the Arabidopsis AXR3 gene. AXR3 was shown to be a member of the AUX/IAA family, providing direct evidence that AUX/IAA genes are central in auxin signaling. Molecular characterization of axr3 gain-of-function and loss-of-function mutations established the functional importance of domains conserved among AUX/IAA proteins.
authors.affiliation: Department of Biology, University of York, York YO1 5YW, UK.
authors.forename: D
authors.initials: D
authors.lastname: Rouse
authors.forename: P
authors.initials: P
authors.lastname: Mackay
authors.forename: P
authors.initials: P
authors.lastname: Stirnberg
authors.forename: M
authors.initials: M
authors.lastname: Estelle
authors.forename: O
authors.initials: O
authors.lastname: Leyser
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics* / Q000502:physiology; D029681:Arabidopsis Proteins; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D017343:Genes, Plant; D007210:Indoleacetic Acids / Q000502:physiology*; D008969:Molecular Sequence Data; D009154:Mutation; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D017354:Point Mutation; D012326:RNA Splicing; D015398:Signal Transduction; D013489:Suppression, Genetic; D014157:Transcription Factors
chemical_list: C110728:AXR3 protein, Arabidopsis; D029681:Arabidopsis Proteins; D007210:Indoleacetic Acids; D009687:Nuclear Proteins; D010940:Plant Proteins; D014157:Transcription Factors