Comparative cytotoxicity of cisplatin, sodium selenite and selenium-cisplatin conjugate [(NH3)2Pt(SeO3)]; changes of blood platelet activation.
The cytotoxic effects of a novel compound, conjugate Se-Pt [(NH3)2Pt (SeO3)] on blood platelet function (aggregation, release of adenine nucleotides) were studied. Contrary to the action of cisplatin or selenite alone, [(NH3)2Pt(SeO3)] did not inhibit ADP-induced platelet aggregation, thrombin-induced release of adenine nucleotides from platelets, and had no effect on the metabolism of platelet arachidonate. The tested compound seems to be less toxic than cisplatin alone, and has no effect on blood platelet activation.
Wachowicz
B
B
Department of General Biochemistry, Institute of Biochemistry, University of Lódź, Poland. Biochogl@Biol.Uni.Lodz.PL
Olas
B
B
D000227:Adenine Nucleotides / Q000097:blood; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000633:toxicity; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D015539:Platelet Activation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000633:toxicity; D018036:Selenium Compounds / Q000633:toxicity*; D018038:Sodium Selenite / Q000633:toxicity*; D013552:Swine
D000227:Adenine Nucleotides; D000970:Antineoplastic Agents; D010975:Platelet Aggregation Inhibitors; D018036:Selenium Compounds; C110743:selenium-cisplatin conjugate; D008315:Malondialdehyde; D018038:Sodium Selenite; D002945:Cisplatin