title: Dehydroepiandrosterone inhibits the growth of DMBA-induced rat mammary carcinoma via the androgen receptor.
abstract: Dehydroepiandrosterone (DHEA) exerts opposite effects on the growth of mammary carcinoma. A stimulatory effect is observed in absence of estrogens, due to interaction of DHEA metabolite(s) with the estrogen receptor (ER); by contrast, in presence of estrogens DHEA inhibits tumor growth. The mechanism underlying the latter DHEA effect, which might be related to activation of the androgen receptor (AR), is poorly understood. Focusing on this point, we measured over a 20 days period the areas of DMBA-induced mammary tumors in rats given DHEA and/or the anti-androgen flutamide (FLU). Results show that DHEA inhibitory effect on the growth of mammary carcinoma is no longer observed when the ARs are blocked by FLU. Data are consistent with an involvement of ARs in the inhibitory effect of DHEA.
authors.affiliation: Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Torino, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Gatto
authors.forename: M
authors.initials: M
authors.lastname: Aragno
authors.forename: M
authors.initials: M
authors.lastname: Gallo
authors.forename: E
authors.initials: E
authors.lastname: Tamagno
authors.forename: A
authors.initials: A
authors.lastname: Martini
authors.forename: M
authors.initials: M
authors.lastname: Di Monaco
authors.forename: E
authors.initials: E
authors.lastname: Brignardello
authors.forename: G
authors.initials: G
authors.lastname: Boccuzzi
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003687:Dehydroepiandrosterone / Q000627:therapeutic use*; D005260:Female; D005485:Flutamide / Q000627:therapeutic use*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011944:Receptors, Androgen / Q000502:physiology*; D013997:Time Factors
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011944:Receptors, Androgen; D003687:Dehydroepiandrosterone; D015127:9,10-Dimethyl-1,2-benzanthracene; D005485:Flutamide