title: [Synthesis and antimicrobial activity of some substituted 3-arylidenaminothienopyrimididones].
abstract: The synthesis of six 2-methyl-3-arylidenoaminocyclohexeno [b] thieno [2,3-d]-3,4-dihydropyrimidin-4-ones is described. The biological activity of these new compounds was screened against several Gram-positive and Gram-negative bacteria. The activity of our compounds is 5 to 320 fold less active than ciprofloxacin.
authors.affiliation: Departamento de Fármacos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Brasil.
authors.forename: R C
authors.initials: RC
authors.lastname: De Oliveira
authors.forename: A C
authors.initials: AC
authors.lastname: Freitas
authors.forename: E C
authors.initials: EC
authors.lastname: Ximenes
authors.forename: J
authors.initials: J
authors.lastname: De Lima
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011744:Pyrimidinones
vernacular_title: Synthèse et activitié antimicrobienne de quelques arylidènamino-3 thiénopyrimidones-4 substituées.