title: Myocardial perfusion, glucose utilization and oxidative metabolism in a patient with left bundle branch block, prior myocardial infarction and diabetes.
abstract: A diabetic patient affected by insulin-dependent diabetes, significant stenosis of left anterior descending (LAD) coronary, thrombolyzed myocardial infarction and complete left bundle branch block (LBBB) was examined by PET. Myocardial perfusion, glucose utilization and oxidative metabolism were evaluated by 13N-ammonia, 18F-fluorodeoxyglucose (FDG) and 11C-acetate, respectively. Despite severe damage in 18F-FDG uptake in the septum, with a septum-to-lateral ratio (S/L R) equal to 0.38, the oxidative metabolism in this area, evaluated quantitatively by dynamic acquisition, was relatively preserved (S/L R = 0.82), with a distribution similar to perfusion (S/L R = 0.87). These data reveal selective damage in glucose utilization in the septum in LBBB, unrelated to perfusion reduction and with preserved oxidative metabolism. Moreover, our experience could suggest an overestimation of the necrotic area by 18F-FDG in LBBB patients.
authors.affiliation: Department of Nuclear Medicine and PET Center, Castelfranco Veneto Hospital, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Zanco
authors.forename: F
authors.initials: F
authors.lastname: Chierichetti
authors.forename: A
authors.initials: A
authors.lastname: Fini
authors.forename: S
authors.initials: S
authors.lastname: Cargnel
authors.forename: G
authors.initials: G
authors.lastname: Ferlin
mesh_terms: D019342:Acetic Acid; D000641:Ammonia; D002037:Bundle-Branch Block / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002250:Carbon Radioisotopes; D003326:Coronary Circulation; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D009206:Myocardium / Q000378:metabolism*; D009590:Nitrogen Radioisotopes; D010084:Oxidation-Reduction; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D009590:Nitrogen Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D000641:Ammonia; D005947:Glucose; D019342:Acetic Acid