Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine.
The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2-propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.
Maruyama
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Y
Department of Neuropsychopharmacology, Gunma University School of Medicine, Japan. yuji@news.sb.gunma-u.ac.jp
Kuribara
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H
Morita
M
M
Yuzurihara
M
M
Weintraub
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ST
D000818:Animals; D014151:Anti-Anxiety Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology; D001713:Biphenyl Compounds / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D017705:Lignans; D008297:Male; D020835:Medicine, Kampo; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D000498:Allyl Compounds; D010636:Phenols
D014151:Anti-Anxiety Agents; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D017705:Lignans; D010936:Plant Extracts; C045086:saiboku-to; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols