[Cognitive deficits in animals fed a hypocaloric diet: analogies to neuropsychological deficits in anorexia nervosa?].
Improvement in cognitive functions with weight gain in patients with anorexia nervosa leads to the assumption of cognitive functions decrease during long-lasting self-starvation. In the present study the effects of chronic undernutrition on learning abilities, in rodents were investigated in an open-field test and a passive avoidance paradigm. The findings suggest that cognitive deficits after a weight loss of 32% of normal weight may be caused by undernutrition. Further research is necessary to clarify other influencing conditions and identify the underlying biochemical mechanisms.
Schmidt
M H
MH
Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters am Zentralinstitut für Seelische Gesundheit Mannheim.
Göpel
C
C
Blanz
B
B
D000818:Animals; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000523:psychology; D001362:Avoidance Learning / Q000502:physiology; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000503:physiopathology* / Q000523:psychology; D004195:Disease Models, Animal; D002149:Energy Intake / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D009483:Neuropsychological Tests; D051381:Rats; D017208:Rats, Wistar; D015431:Weight Loss / Q000502:physiology*
Kognitive Defizite bei hypokalorisch ernährten Tieren: Analogien zu neuropsychologischen Defiziten bei Anorexia nervosa?