title: Darier-White disease: a report of a case in a Nigerian with a review of the literature.
abstract: Darier's disease is a genetic disorder inherited as a autosomal dominant. The aetiology is unknown but electron microscopic studies suggest that the essential abnormality is a defect in the synthesis, organization, or maturation of the tonofilament-desmosome complex, which leads to abnormal keratinization. Reports of this condition in Africans is uncommon. We present here a case of Darier's Disease in a 70 year old Nigerian woman. As far as we know, it is the first reported case in a Nigerian. Clinical variants, complications, and differential diagnoses of Darier's disease are discussed.
authors.affiliation: Department of Medicine, University College Hospital, Ibadan, Nigeria.
authors.forename: O A
authors.initials: OA
authors.lastname: Ogunbiyi
authors.forename: J O
authors.initials: JO
authors.lastname: Ogunbiyi
mesh_terms: D000368:Aged; D007644:Darier Disease / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006801:Humans; D012867:Skin / Q000473:pathology