title: Inheritance of CYP6D1-mediated pyrethroid resistance in house fly (Diptera: Muscidae).
abstract: The inheritance of cytochrome P450 monooxygenase-mediated (i.e., CYP6D1) resistance in the LPR strain of house fly, Musca domestica L., was investigated by comparing levels of monooxygenase-mediated permethrin resistance and CYP6D1 messenger RNA in 7 populations of house flies. Results indicate that monooxygenase-mediated resistance, and overexpression of CYP6D1 in the LPR strain are controlled by an incompletely recessive trans acting factor(s) on autosome 2 and a nearly completely dominant cis acting factor(s) on autosome 1. The polygenic nature of CYP6D1-mediated resistance and the relative dominance of the resistance factor(s) on autosome 1 suggests this type of resistance could develop relatively quickly.
authors.affiliation: Department of Entomology, Cornell University, Ithaca, NY 14853-0901, USA.
authors.forename: N
authors.initials: N
authors.lastname: Liu
authors.forename: J G
authors.initials: JG
authors.lastname: Scott
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000072472:Cytochrome P450 Family 6; D005260:Female; D006579:Heterozygote; D019476:Insect Proteins; D007305:Insecticide Resistance / Q000235:genetics; D007306:Insecticides; D008297:Male; D009117:Muscidae / Q000201:enzymology* / Q000235:genetics; D026023:Permethrin; D011722:Pyrethrins; D012333:RNA, Messenger
chemical_list: D019476:Insect Proteins; D007306:Insecticides; D011722:Pyrethrins; D012333:RNA, Messenger; D026023:Permethrin; D003577:Cytochrome P-450 Enzyme System; C092307:CYP6D1 protein, Musca domestica; D000072472:Cytochrome P450 Family 6