[The transport-trophic support of myocardial function in the modelling of chronic ischemic heart disease].
Using a model of chronic ischemic heart disease (recurring coronary insufficiency against the background of chronic hypercholesterolemia), regularities were studied of the microcirculation rearrangements in the myocardium. Employed in the studies were methods of light optics, electron microscopy, injection, as was morphometry. All structural and functional links of the myocardial microcirculation system were put to study, such as resistive, metabolic and blood-drawing segments of the microhemocirculatory channel, intramyocardial tracts of lymph outflow, and interstitium as a direct carrier of the intratissue milieu, as well as subepicardial portion of the lymphatic network of the heart. There have been determined the morphofunctional equivalents and morphogenesis of those changes disorganizing the transport processes in the myocardium under the above type disorder, such as changes in microhaemodynamics, permeability of the histohematic barrier, lymph outflow, and intermediary exchange; there have also been analysed the pathogenetic interrelations thereof. The results obtained suggest that dysfunction of the myocardial system of microcirculation should have a part as a local tissue factor of pathogenesis of cardiac insufficiency in ischemic heart disease.
Gavrish
A S
AS
Rudnitskaia
O G
OG
Blagodarov
V N
VN
D000818:Animals; D001693:Biological Transport, Active; D002199:Capillary Permeability; D002908:Chronic Disease; D004036:Diet, Atherogenic; D006321:Heart / Q000503:physiopathology*; D008833:Microcirculation / Q000503:physiopathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D011817:Rabbits; D013997:Time Factors
Transportno-troficheskoe obespechenie funktsii miokarda pri modelirovanii khronicheskoĭ ishemicheskoĭ bolezni serdtsa.