title: [Oral contraceptive use and vaginal candida colonization].
abstract: Fungal vaginal infections/colonisations can be divided into a symptomatic vaginal candidiasis and an asymptomatic vaginal Candida-carriage. The latter seems to be a predisposing factor for the development of a symptomatic vaginal candidiasis. The fungal organism isolated most frequently is Candida albicans, followed by Candida glabrata, which was previously also known as Torulopsis glabrata. To a lower extend, other Candida species such as Candida tropicalis and Candida krusei can be prevalent in the vulvovaginal region. Predisposing factors for vaginal candidiasis are gravidity, diabetes mellitus or a therapy with immunosuppressive agents. Also gestagenes showed to be a pre-disposing factor for vaginal candidiasis. Divergent results concerning the predisposition to vaginal candidiasis or colonisation due to oral contraception have so far been reported. Therefore we performed a study with two healthy collectives of female volunteers (n = 2 x 60) which were different concerning the taking of oral contraceptives. Overall, in 17% of the subjects (20/120) yeast could be cultured out of the vaginal secretions. There was no evidence for a higher rate of Candida-colonisation in subjects taking oral contraceptives. Further, there was no evidence for a relationship between the length of the taking of oral contraceptives and the rate of vaginal yeast-carriage. Also the type of oral contraceptive (combination or sequential contraceptive) had no influence on the frequency of Candida-carriage. Candida albicans was the most prevalent yeast (16/20), followed by Candida glabrata (4/20).
authors.affiliation: Institut für Mikrobiologie und Virologie, Universität Witten/Herdecke.
authors.forename: A
authors.initials: A
authors.lastname: Schmidt
authors.forename: C F
authors.initials: CF
authors.lastname: Nöldechen
authors.forename: W
authors.initials: W
authors.lastname: Mendling
authors.forename: W
authors.initials: W
authors.lastname: Hatzmann
authors.forename: M H
authors.initials: MH
authors.lastname: Wolff
mesh_terms: D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000139:chemically induced*; D002353:Carrier State / Q000382:microbiology; D003276:Contraceptives, Oral / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D012307:Risk Factors; D014621:Vagina / Q000382:microbiology
chemical_list: D003276:Contraceptives, Oral
vernacular_title: Einnahme oraler Kontrazeptiva und vaginale Kandidabesiedlung.