Comparison of dose doubling with probenecid for sustaining serum cefuroxime levels.
Serum cefuroxime concentrations were measured over a 12 h period in ten healthy adults following three iv dosing regimens: 750 mg cefuroxime, 1.5 g cefuroxime, and 750 mg cefuroxime with 1 g of probenecid given orally 3 h before the cefuroxime infusion. Probenecid prolonged the serum cefuroxime half-life by 63% (P < 0.05) with a significant increase in the mean time for which serum cefuroxime concentrations exceeded the MIC90 for common respiratory pathogens (2 mg/L) compared with either 750 mg cefuroxime (2.2 h, P < 0.05) or 1.5 g of cefuroxime (0.9 h, P < 0.05) without probenecid. The cost of the 750 mg cefuroxime dose plus probenecid is approximately half that of a 1.5 g cefuroxime dose.
Garton
A M
AM
Department of Pharmacy, University of Alberta Hospitals, Edmonton, Canada.
Rennie
R P
RP
Gilpin
J
J
Marrelli
M
M
Shafran
S D
SD
D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D002444:Cefuroxime / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011339:Probenecid / Q000008:administration & dosage / Q000494:pharmacology*; D012076:Renal Agents / Q000494:pharmacology*
D002511:Cephalosporins; D012076:Renal Agents; D002444:Cefuroxime; D011339:Probenecid