The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymes.
A 2-His-1-carboxylate facial triad is a common feature of the active sites in a number of mononuclear non-heme iron(II) enzymes. This structural motif was established crystallographically for five different classes of enzymes and inferred from sequence similarity for two other classes. The 2-His-1-carboxylate facial triad anchors the iron in the active site and at the same time maintains three additional cis-oriented sites. These sites can be used to bind other endogenous ligands or exogenous ligands such as substrate and/or O2, giving the metal center great flexibility to use different mechanistic strategies to perform a variety of chemical transformations.
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Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis 55455, USA.
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D001665:Binding Sites; D002384:Catalysis; D018360:Crystallography, X-Ray; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism; D007501:Iron / Q000737:chemistry; D008024:Ligands; D019159:Nonheme Iron Proteins / Q000737:chemistry*; D010100:Oxygen / Q000378:metabolism
D004798:Enzymes; D008024:Ligands; D019159:Nonheme Iron Proteins; D007501:Iron; D010100:Oxygen