Association between IgE antibody against soluble egg antigen and resistance to reinfection with Schistosoma japonicum.
There is evidence that immunoglobulin (Ig) E antibody may be a critical component of protective immunity against Schistosoma mansoni and S. haematobium reinfection. In the present study, 555 individuals aged 3-67 years infected with S.japonicum received praziquantel treatment before the transmission season commenced; 45 d later, blood samples from 265 individuals who had no S. japonicum egg in their stool were examined by enzyme-linked immunosorbent assay for specific isotypic antibodies. Single, non-conditional logistic regression analysis showed that exposure intensity, age, soluble egg antigen (SEA)-IgE, SEA-IgM and soluble adult worm antigen-IgG4 were relevant to reinfection; multiple, non-conditional logistic regression analysis showed that exposure intensity was still a significant factor for reinfection while the SEA-IgE antibody level was associated with resistance to reinfection with S. japonicum, with a protective index of 2.00. It is suggested that this population in an area endemic for schistosomiasis japonica exhibits acquired immunity.
Zhang
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Molecular and Immunoparasitology Research Department, Nanjing Medical University, Nanjing, China.
Wu
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Chen
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Hu
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L
Xie
Z
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Qiu
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Y
Su
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Cao
J P
JP
Wu
Y
Y
Zhang
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Wu
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G
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000909:Antibodies, Helminth / Q000097:blood*; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002681:China; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016015:Logistic Models; D008875:Middle Aged; D011223:Praziquantel / Q000627:therapeutic use; D012008:Recurrence; D012554:Schistosomiasis japonica / Q000188:drug therapy / Q000276:immunology*
D000909:Antibodies, Helminth; D000980:Antiplatyhelmintic Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E; D011223:Praziquantel