title: Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin.
abstract: OBJECTIVE
  To determine side effect profiles and cure rates of azithromycin compared with erythromycin in the treatment of chlamydial cervicitis complicating pregnancy.
  
  
  METHODS
  Pregnant patients with positive DNA antigen assays for Chlamydia trachomatis were randomized to either azithromycin, 1 g oral slurry in a single dose, or erythromycin, 500 mg every 6 hours for 7 days. Repeat assays were planned for 3 weeks after therapy. Side effects, compliance, and treatment efficacy were assessed.
  
  
  RESULTS
  One hundred six women were enrolled, and eighty-five women completed the protocol. Significantly fewer gastrointestinal side effects were noted in the azithromycin group than in the erythromycin group (11.9% versus 58.1%, P < or = .01). Enhanced compliance was noted with azithromycin, because it was given in a single observed dose. Similar treatment efficacy was noted between azithromycin and erythromycin (88.1% versus 93.0%, P > .05).
  
  
  CONCLUSIONS
  Compared with erythromycin, azithromycin is associated with significantly fewer gastrointestinal side effects in pregnancy. This association, along with the ease of administration and similar efficacy, suggests that azithromycin should be considered for the initial treatment of chlamydial cervicitis in pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, The Bowman Gray School of Medicine/Wake Forest University, Winston-Salem, North Carolina, USA. dadair@mail-sh.lsumc.edu
authors.forename: C D
authors.initials: CD
authors.lastname: Adair
authors.forename: M
authors.initials: M
authors.lastname: Gunter
authors.forename: T G
authors.initials: TG
authors.lastname: Stovall
authors.forename: G
authors.initials: G
authors.lastname: McElroy
authors.forename: J C
authors.initials: JC
authors.lastname: Veille
authors.forename: J M
authors.initials: JM
authors.lastname: Ernest
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017963:Azithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis; D004917:Erythromycin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D002575:Uterine Cervicitis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D017963:Azithromycin