title: Tryptophan ingestion by gestant mothers alters prolactin and luteinizing hormone release in the adult male offspring.
abstract: The effect of tryptophan administration to pregnant rats on the development of serotonergic systems and serotonin-related hormones in the offspring was studied. The male offspring of rats treated with tryptophan (200 mg/kg/day) during the second half of gestation showed a 4- to 7-fold increase in serum prolactin 40 and 70 days after birth and a 2-fold increase in serum luteinizing hormone 70 days after birth. The forebrain of adult offspring of tryptophan-treated rats showed an increase in serotonin and 5-hydroxyindoleacetic acid levels. Present data suggest that tryptophan regulates serotonergic differentiation during early development.
authors.affiliation: Canarian University Hospital, University of La Laguna, Tenerife, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez Díaz
authors.forename: C
authors.initials: C
authors.lastname: Santana-Herrera
authors.forename: A
authors.initials: A
authors.lastname: Milena
authors.forename: C
authors.initials: C
authors.lastname: Santana
mesh_terms: D000375:Aging / Q000097:blood*; D000818:Animals; D000831:Animals, Newborn / Q000097:blood* / Q000254:growth & development; D005260:Female; D005865:Gestational Age; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011388:Prolactin / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D014364:Tryptophan / Q000494:pharmacology*
chemical_list: D014364:Tryptophan; D011388:Prolactin; D007986:Luteinizing Hormone