title: Unsuspected uterine leiomyosarcoma discovered during treatment with a gonadotropin-releasing hormone analogue: a case report and literature review.
abstract: We report a case of a 37-year-old woman who had received five courses of gonadotropin-releasing hormone (GnRH) agonist (Decapeptyl) for presumed uterine leiomyomata associated with episodes of uterine bleeding. Submucous myoma (histologically proven) was partially removed on the first visit. After a period of significant reduction in the tumor size and cessation of uterine bleeding, the symptoms recurred along with rapid re-growth of the uterus. Total abdominal hysterectomy was performed and the pathologic evaluation revealed leiomyosarcoma with a high mitotic rate. This case and the literature review emphasize the problems encountered with the early diagnosis of uterine leiomyosarcoma during GnRH agonist therapy.
authors.affiliation: Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Milman
authors.forename: Y
authors.initials: Y
authors.lastname: Zalel
authors.forename: H
authors.initials: H
authors.lastname: Biran
authors.forename: M
authors.initials: M
authors.lastname: Open
authors.forename: B
authors.initials: B
authors.lastname: Caspi
authors.forename: Z
authors.initials: Z
authors.lastname: Hagay
authors.forename: R
authors.initials: R
authors.lastname: Dgani
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008938:Mitosis; D017329:Triptorelin Pamoate / Q000627:therapeutic use*; D014592:Uterine Hemorrhage; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017329:Triptorelin Pamoate