title: Protection by a commercial Arkansas-type infectious bronchitis virus vaccine against a field isolate of the same serotype.
abstract: A late-breaking infectious bronchitis virus (IBV)-associated respiratory disease was a chronic problem in Georgia broilers in 1995. The predominant virus isolated from diseased birds was the Arkansas (Ark) type of IBV. Because broilers in Georgia are currently vaccinated with the Arkansas serotype, there was concern that a phenotypic and/or genotypic change had occurred in the field virus so it could break through immunity conferred by commercial vaccines. The purpose of this study was to determine if a commercially available vaccine for IBV as currently used in the field still protected broilers against those viruses. We obtained 108 1-day-old broilers from a commercial source and assigned them randomly to 12 groups. One-half of the groups of birds were vaccinated at 1 day of age and again at 18 days of age with commercially available B1/Mass/Ark vaccine. One-half of both vaccinated and nonvaccinated groups of birds were challenged at 35 and 42 days of age with a recent IBV Ark field isolate. Serologic titers were evaluated by enzyme-linked immunosorbent assay at time of challenge and at the end of the trial. A necropsy was performed on birds at 56 days and pathogenicity was assessed. Seroconversion was statistically significant in all birds exposed to vaccine or challenge by 56 days of age. Gross airsacculitis was significantly more severe in broilers challenged without prior exposure to vaccine.
authors.affiliation: Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602-4875, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Sander
authors.forename: M W
authors.initials: MW
authors.lastname: Jackwood
authors.forename: G N
authors.initials: GN
authors.lastname: Rowland
mesh_terms: D000818:Animals; D002645:Chickens; D018352:Coronavirus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods / Q000662:veterinary; D005838:Genotype; D005845:Georgia / Q000453:epidemiology; D001351:Infectious bronchitis virus / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D010641:Phenotype; D011201:Poultry Diseases / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D014765:Viral Vaccines