[The role of C-reactive protein (CRP) determination in the early diagnosis of infections with opportunistic microorganisms in HIV-infected children].
The levels of C-reactive protein (CRP) in sera of 71 HIV-seropositive children and of 71 apparently healthy children were determined by Mancini method. The results demonstrate that HIV-infection per se doesn't increase the concentration of CRP in serum. After this we wanted to determine the relationship between CRP and evolution of HIV-infection. For this we used a set of 8 children in different stages of HIV-infection. For each child we had at least 2 sera, used for diagnosis and CRP assay. Three children (one with AIDS [correction of SIDA] and 2 in intermediate stage) had elevated levels of CRP. The reason for these elevations were an acute salmonellosis, a febrile episode of unknown origin and for the last child, once a staphylococcal infection of the skin and once an acute bronchiolitis clinically but not microbiologically documented. In conclusion, HIV-infection per se doesn't induce increased levels of the CRP, in any stage; this protein could be used as a marker of bacterial, parasitic and cytomegalovirus infections.
Diculencu
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Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Apetrei
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C
Iancu
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LS
Bosnea
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D
D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015497:HIV-1; D006801:Humans; D005779:Immunodiffusion; D007223:Infant; D008297:Male; D013997:Time Factors
D015415:Biomarkers; D015483:HIV Antibodies; D002097:C-Reactive Protein
Rolul dozării proteinei C-reactive (CRP) în depistarea precoce a suprainfecţiilor cu microorganisme condiţionat patogene la copii HIV-infectaţi.