Preparation and characterization of sustained-release microspheres of chlorpromazine.
Sustained release microspheres of chlorpromazine were prepared from Eudragit RS 100 by an emulsion-solvent evaporation method using a six-baffled vessel. The morphology of microspheres was characterized by scanning electron microscopy (SEM). In the presence of aluminium tristearate (5%), microspheres were spherical in shape and uniform. The release of chlorpromazine from microspheres was pH-independent. With increasing amount of aluminium tristearate and increasing ratio of Eudragit RS 100/drug from 1:1 to 9:1, the particle size of chlorpromazine microspheres was reduced and the release rate decreased. The microspheres prepared with the polymer/drug ratio of 9:1 produced a 12-h sustained release pattern.
Gao
Z G
ZG
College of Pharmacy, Seoul National University, South Korea.
Oh
K H
KH
Kim
C K
CK
D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D002746:Chlorpromazine / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D008863:Microspheres
D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D002746:Chlorpromazine