Effect of mitral regurgitation on coagulation activity in atrial fibrillation.
We measured the plasma levels of molecular markers for thrombotic and fibrinolytic status in patients with nonrheumatic atrial fibrillation (AF) to investigate the relation between coagulation activity and mitral regurgitation (MR). Our findings demonstrated that a greater degree of MR was associated with less coagulation activity in patients with nonrheumatic AF, suggesting that MR protects against left atrial thrombus and systemic thromboembolism.
Fukazawa
H
H
Department of Cardiology, Jichi Medical School, Minamikawachi, Tochigi, Japan.
Yamamoto
K
K
Ikeda
U
U
Shimada
K
K
D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III / Q000378:metabolism*; D001281:Atrial Fibrillation / Q000097:blood* / Q000150:complications*; D016022:Case-Control Studies; D018618:Echocardiography, Doppler, Color; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000097:blood* / Q000150:complications* / Q000000981:diagnostic imaging; D010446:Peptide Fragments / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D011516:Prothrombin / Q000378:metabolism*
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D011498:Protein Precursors; C036309:fibrin fragment D; C029733:prothrombin fragment 1; C044183:prothrombin fragment 2; D000990:Antithrombin III; D011516:Prothrombin