[HLA genes in patients with pulmonary tuberculosis in the Kirghiz population].
The immunogenetic features of the HLA system were studied in 116 Kirghiz patients with pulmonary tuberculosis and 120 apparently healthy individuals of the same nationality (a control group). HLA antigen typing was made by the routine microlymphocytotoxic test. The antigens Bw53, Bw62(15), DR2 and DR7 which should be regarded as markers of the disease were more commonly found in the HLA phenotype in Kirghiz patients with tuberculosis than in healthy individuals. The risk for tuberculosis increased in carriers having HLA haplotypes with the DR allele.
Alisherov
A S
AS
Kirghiz NII of Tuberculosis, Bishkek.
Kitaev
M I
MI
Tarasenko
O M
OM
Tiurebaeva
B N
BN
D005260:Female; D005805:Genes, MHC Class I / Q000276:immunology*; D005802:Genes, MHC Class II / Q000276:immunology*; D005819:Genetic Markers; D006680:HLA Antigens / Q000276:immunology; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D007707:Kyrgyzstan; D008297:Male; D010375:Pedigree; D010641:Phenotype; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000235:genetics / Q000276:immunology*
D005819:Genetic Markers; D006680:HLA Antigens
Geny kompleksa HLA u bol'nykh tuberkulezom legkikh v Kirgizskoí populiatsii.