title: A bacterial RNA that functions as both a tRNA and an mRNA.
abstract: Bacterial tmRNA (transfer-messenger RNA, also known as 10Sa RNA) contains a tRNA-like structure in the 5'- and 3'-end sequences and an internal reading frame encoding a 'tag' peptide. The dual function of this molecule as both a tRNA and an mRNA facilitates a trans-translation reaction, in which a ribosome can switch between translation of a truncated mRNA and the tmRNA's tag sequence. The result is a chimeric protein with the tag peptide attached to the C-terminus of the truncated peptide.
authors.affiliation: Department of Biology, Faculty of Science, Hirosaki University, Japan. muto@cc.hirosaki-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Muto
authors.forename: C
authors.initials: C
authors.lastname: Ushida
authors.forename: H
authors.initials: H
authors.lastname: Himeno
mesh_terms: D001483:Base Sequence; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012329:RNA, Bacterial / Q000502:physiology*; D012333:RNA, Messenger / Q000502:physiology*; D012343:RNA, Transfer / Q000502:physiology*
chemical_list: D012329:RNA, Bacterial; D012333:RNA, Messenger; C096222:tmRNA; D012343:RNA, Transfer