title: Effects of amphetamine on the development of Moloney sarcoma virus-induced tumors in mice.
abstract: Experiments were conducted to evaluate the effects of amphetamine (0. 4 mg/kg) on the development of autochthonous tumors induced by the Moloney sarcoma virus (MSV) in Balb/c female mice. Enhancement of MSV-induced tumor incidence and tumor growth was observed, together with a delay in the usual prompt regression of the tumors, when mice were daily injected with amphetamine for 3 days after MSV-inoculation. However, no effects of amphetamine on tumor development were observed when it was administered during the 3 days before tumor inoculation.
authors.affiliation: Department of Pharmacology, School of Pharmacy, University of Santiago de Compostela, Campus Sur, Santiago de Compostela, 15706, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Freire-Garabal
authors.forename: M J
authors.initials: MJ
authors.lastname: Nuñez-Iglesias
authors.forename: M
authors.initials: M
authors.lastname: Rey-Méndez
authors.forename: M D
authors.initials: MD
authors.lastname: Pereiro-Raposo
authors.forename: P
authors.initials: P
authors.lastname: Riveiro
authors.forename: J C
authors.initials: JC
authors.lastname: Fernández-Rial
authors.forename: C
authors.initials: C
authors.lastname: Losada
authors.forename: M
authors.initials: M
authors.lastname: Gandoy
authors.forename: J M
authors.initials: JM
authors.lastname: Mayán
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007279:Injections, Subcutaneous; D051379:Mice; D008807:Mice, Inbred BALB C; D008980:Moloney murine sarcoma virus; D011292:Premedication; D012192:Retroviridae Infections / Q000188:drug therapy / Q000473:pathology*; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000473:pathology*; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000473:pathology*
chemical_list: D018663:Adrenergic Agents; D000661:Amphetamine