Neutrophil phagocytosis in AIDS patients with azole resistant candidiasis.
OBJECTIVE
This study aimed to evaluate phagocytosis of C. albicans by neutrophils in 10 AIDS patients and 50 control subjects. Five of the AIDS patients were colonised with azole-resistant C. albicans isolates and five with azole-sensitive isolates.


CONCLUSIONS
Percentage phagocytosis was within normal limits for seven of the 10 AIDS patients and was reduced in the remaining three patients. Phagocytosis was unaffected by the carriage of azole resistant C. albicans, and the patients' own strains were phagocytosed as readily as a standard strain of C. albicans. This study suggests that azole resistance is not related to impaired phagocytosis in AIDS patients.
Diz Dios
P
P
Santiago de Compostela University, Vigo, Spain.
Iglesias
I
I
Valcarcel
J P
JP
Ocampo
A
A
Vazquez
E
E
Castro
M
M
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology* / Q000503:physiopathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000935:Antifungal Agents / Q000494:pharmacology; D001393:Azoles / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D002180:Candidiasis, Oral / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D016022:Case-Control Studies; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D016867:Immunocompromised Host; D009504:Neutrophils / Q000502:physiology*; D009960:Oropharynx; D010587:Phagocytosis / Q000502:physiology*
D000935:Antifungal Agents; D001393:Azoles; D015725:Fluconazole