Decreased nuclear encoded subunits of cytochrome c oxidase and increased copper, zinc-superoxide dismutase activity are found in cardiomyopathic human hearts.
Mineral concentrations, copper, zinc-superoxide dismutase and cytochrome c oxidase subunits in human cardiomyopathic heart explants were compared with noncardiomyopathic hearts from autopsy subjects. Iron was reduced in cardiomyopathic hearts, but the zinc:iron ratio was higher in cardiomyopathic hearts. Copper, zinc-superoxide dismutase activity was increased in cardiomyopathic human hearts compared to the noncardiomyopathic hearts. In a subsample of specimens analyzed, the nuclear encoded subunits of cytochrome c oxidase were diminished in the cardiomyopathic hearts. The decreases have been observed in rodents fed copper-deficient diets. However, in this study heart copper levels did not differ by disease status.
Liebes
R
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Department of Human Nutrition and Food Management, The Ohio State University, Columbus 43210-1295, USA.
Medeiros
D M
DM
D000328:Adult; D000368:Aged; D002118:Calcium / Q000032:analysis; D003300:Copper / Q000032:analysis; D003576:Electron Transport Complex IV / Q000032:analysis*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006331:Heart Diseases / Q000201:enzymology*; D006801:Humans; D007501:Iron / Q000032:analysis; D008274:Magnesium / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000737:chemistry*; D011188:Potassium / Q000032:analysis; D012016:Reference Values; D012964:Sodium / Q000032:analysis; D013482:Superoxide Dismutase / Q000032:analysis*; D015032:Zinc / Q000032:analysis
D003300:Copper; D012964:Sodium; D007501:Iron; D013482:Superoxide Dismutase; D003576:Electron Transport Complex IV; D008274:Magnesium; D015032:Zinc; D011188:Potassium; D002118:Calcium