title: Novel bromopyrrole alkaloids from the sponge Agelas dispar.
abstract: Further investigation of the Caribbean marine sponge Agelas dispar for biologically active constituents has led to the isolation of the novel bromopyrrole alkaloids longamide B (1), and clathramides C (2) and D (3), whose structures have been determined by spectroscopic methods. Isolation of the known keramadine (4) and of the ecdysonic sterols ecdysterone (5) and ajugasterone C (6) is also reported. The antimicrobial activities of the isolated bromopyrrole alkaloids is summarized.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Napoli, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cafieri
authors.forename: E
authors.initials: E
authors.lastname: Fattorusso
authors.forename: O
authors.initials: O
authors.lastname: Taglialatela-Scafati
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents