Bone remodeling with resorbable bioactive glass and hydroxyapatite.
Particulate resorbable bioactive glass and resorbable hydroxyapatite did not inhibit the growth of periodontal ligament cells and osteoblasts in cultures. Both cell types promoted the activation of alkaline phosphatase around the surface of bioactive glass particles. When bioactive glass and hydroxyapatite were cultured with peripheral blood lymphocytes/monocytes, the number of nonadherent and adherent cells was the same as observed with a control. Resorbable bioactive glass activated the cells necessary for bone formation better than hydroxyapatite and suppressed the formation of osteoclasts for bone resorption. Resorbable bioactive glass and resorbable hydroxyapatite were found to be harmless to periodontium cells and lymphocytes/monocytes.
Shimizu
Y
Y
Department of Oral Bacteriology, Tohoku University, School of Dentistry, Sendai, Japan.
Sugawara
H
H
Furusawa
T
T
Mizunuma
K
K
Inada
K
K
Yamashita
S
S
D000042:Absorption; D000328:Adult; D001672:Biocompatible Materials / Q000494:pharmacology*; D016723:Bone Remodeling / Q000187:drug effects*; D002478:Cells, Cultured; D003764:Dental Materials / Q000494:pharmacology*; D017886:Durapatite / Q000494:pharmacology*; D005898:Glass; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects; D010513:Periodontal Ligament / Q000166:cytology / Q000187:drug effects; D013997:Time Factors
D001672:Biocompatible Materials; C073544:Biogran; D003764:Dental Materials; D017886:Durapatite