Lactogenic hormone signal transduction.
The peptide hormone prolactin (PRL) is known to regulate numerous target tissues. Among the less well-known targets are cells of the immune system, including T cells, B cells, and macrophages. Our laboratory has cloned a panel of PRL-inducible T-cell activation genes for use in studies investigating how PRL modulates the biology of cells of the immune system. This article focuses on two such PRL-inducible genes. One is a transcription factor called interferon regulatory factor-1, whose expression is regulated by signaling molecules along the PRL-inducible JAK/Stat signaling pathway. These signaling molecules include Stat1 and CBP as positive mediators and, unexpectedly, Stat5b as a negative mediator. A second PRL-inducible gene is c15/RNUDC, a novel nuclear movement protein, which may provide a link between PRL signaling and signaling via the lipid second messenger, platelet activating factor.
Yu-Lee
L Y
LY
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA. yulee@bcm.tmc.edu
Luo
G
G
Book
M L
ML
Morris
S M
SM
D000818:Animals; D005260:Female; D006801:Humans; D011247:Pregnancy; D011388:Prolactin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D011388:Prolactin