title: Choroidal readaptation to gravity in rats after spaceflight and head-down tilt.
abstract: To determine when choroidal structures were restored after readaptation to Earth gravity or orthostatic position, fine structure and protein distribution were studied in rat choroid plexus dissected either 6 h [Space Life Sciences-2 (SLS-2) experiments] or 2 days [National Institutes of Health-Rodent 1 (NIH-R1) experiments] after a spaceflight, or 6 h after head-down tilt (HDT) experiments. Apical alterations were noted in choroidal cells from SLS-2 and HDT animals, confirming that weightlessness impaired choroidal structures and functions. However, the presence of small apical microvilli and kinocilia and the absence of vesicle accumulations showed that the apical organization began to be restored rapidly after landing. Very enlarged apical microvilli appeared after 2 days on Earth, suggesting increased choroidal activity. However, as distributions of ezrin and carbonic anhydrase II remained altered in both flight and suspended animals after readaptation to Earth gravity, it was concluded that choroidal structures and functions were not completely restored, even after 2 days in Earth's gravity.
authors.affiliation: Centre National de la Recherche Scientifique, Université de Montpellier II, France.
authors.forename: J
authors.initials: J
authors.lastname: Davet
authors.forename: B
authors.initials: B
authors.lastname: Clavel
authors.forename: L
authors.initials: L
authors.lastname: Datas
authors.forename: L
authors.initials: L
authors.lastname: Mani-Ponset
authors.forename: D
authors.initials: D
authors.lastname: Maurel
authors.forename: S
authors.initials: S
authors.lastname: Herbuté
authors.forename: M
authors.initials: M
authors.lastname: Viso
authors.forename: W
authors.initials: W
authors.lastname: Hinds
authors.forename: J
authors.initials: J
authors.lastname: Jarvi
authors.forename: J
authors.initials: J
authors.lastname: Gabrion
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D002256:Carbonic Anhydrases / Q000378:metabolism; D002831:Choroid Plexus / Q000502:physiology* / Q000648:ultrastructure; D003598:Cytoskeletal Proteins; D006112:Gravitation; D018475:Head-Down Tilt / Q000502:physiology*; D019417:Hindlimb Suspension; D007150:Immunohistochemistry; D010750:Phosphoproteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013026:Space Flight; D018474:Weightlessness Simulation; D000099149:Ezrin
chemical_list: D002256:Carbonic Anhydrases; D003598:Cytoskeletal Proteins; D010750:Phosphoproteins; D000099149:Ezrin