[Hyperhomocysteinemia. A risk factor for the development of vascular diseases not associated with lipid levels].
BACKGROUND
Elevated total homocysteine plasma levels are considered a significant factor of vascular damage. As they are encountered in more than half the patients with atherosclerotic vascular damage the importance as a lipid-dependent or lipid-independent risk factor in the promotion of pathophysiological processes is discussed.


RESULTS
In a group of 100 healthy subjects and 529 patients with indication for an aortocoronary or peripheral arterial bypass and in patients from the lipid clinic the mutual relation between total plasma homocysteine levels and selected indicators of the lipid metabolism was investigated. The following results more obtained: for total cholesterol a correlation coefficient of r = 0.26, for HDL-cholesterol r = 0.20, for LDL-cholesterol r = 0.21, for triacylglycerols r = 0.29, apolipoprotein A-I r = 0.06, apolipoprotein B r = -0.12 and for Lp(a) r = -0.03. To ensure correct evaluation of the homocysteine levels simultaneously also folate levels were examined (correlation coefficient r = 0.28), vitamin B12 r = (0.03) and fibrinogen r = (0.09).


CONCLUSIONS
The authors did not detect an unequovical relationship between the total homocysteine level and selected lipid indicators in any of the patient groups (p < 0.05).
Hyánek
H
H
Oddĕlení klinické biochemie, nemocnice Na Homolce, Praha.
Stríbrný
J
J
Sebesta
P
P
Niederle
P
P
Kramár
J
J
Kozich
V
V
Orendác
O
O
Zayková
K
K
Mandysová
E
E
Borůvka
V
V
Dvoráková
J
J
Táborský
L
L
Loucka
M
M
Dubská
L
L
Martiníková
V
V
Machácková
L
L
Cabrnochová
I
I
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood* / Q000378:metabolism; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D008055:Lipids; D006710:Homocysteine
Hyperhomocysteinémie. Rizikový faktor pro vznik cévních onemocnĕní nezávislý na hladinách lipidů.