title: Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis.
abstract: BACKGROUND
  Osteoporosis occurs in patients with cystic fibrosis as they age, but its clinical implications are not well defined.
  
  
  OBJECTIVE
  To determine the clinical effect of decreased bone mineral density in adults with cystic fibrosis and to assess possible clinical predictors of osteoporosis.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Academic cystic fibrosis center.
  
  
  METHODS
  70 adults with late-stage cystic fibrosis who were referred for lung transplantation.
  
  
  METHODS
  Bone mineral density was measured with dual-energy x-ray absorptiometry, patient-reported fracture events were confirmed by radiography, and kyphosis angles were measured by using the Cobb method.
  
  
  RESULTS
  Mean bone mineral densities for the spine, femur, and total body were severely depressed in patients with cystic fibrosis, averaging 2 SDs below those of age-matched normal controls (P < 0.001). Patient interviews showed that 54 fractures had occurred over 1410 patient-years, and chest radiographs showed evidence of 14 additional rib and 62 additional vertebral compression fractures. The database (which covered 1410 patient-years) showed that fracture rates were approximately twofold greater in women with cystic fibrosis aged 16 to 34 years (P = 0.015) and men with cystic fibrosis aged 25 to 45 years (P = 0.04) than in the general population. Vertebral compression and rib fractures were 100- and 10-fold more common than expected, respectively (P < 0.001 for both comparisons). The mean kyphosis angle (+/- SD) for this group was markedly abnormal (44 +/- 14 degrees; 62% > or = 40 degrees) and probably contributed to diminished stature (mean height loss, 5.8 cm in men with cystic fibrosis and 5.9 cm in women with cystic fibrosis). Cumulative prednisone dose, body mass index, and age at puberty were the strongest predictors of bone mineral density.
  
  
  CONCLUSIONS
  Osteoporosis is universal in adults with late-stage cystic fibrosis, and its complications include increased fracture rates and severe kyphosis.
authors.affiliation: Division of Pulmonary Medicine, University of North Carolina at Chapel Hill 27599-7524, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Aris
authors.forename: J B
authors.initials: JB
authors.lastname: Renner
authors.forename: A D
authors.initials: AD
authors.lastname: Winders
authors.forename: H E
authors.initials: HE
authors.lastname: Buell
authors.forename: D B
authors.initials: DB
authors.lastname: Riggs
authors.forename: G E
authors.initials: GE
authors.lastname: Lester
authors.forename: D A
authors.initials: DA
authors.lastname: Ontjes
mesh_terms: D000328:Adult; D015519:Bone Density; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D050723:Fractures, Bone / Q000209:etiology*; D006801:Humans; D007738:Kyphosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D013223:Statistics as Topic