Chemokines and chemokine receptors: the key to understanding AIDS.
This article reviews the recent rapid developments in research that have demonstrated the importance of chemokines and their receptors in HIV infection and the progression to AIDS. These discoveries have transformed our understanding of how the virus may infect cells and why certain individuals may be resistant to HIV infection, and for the first time have opened up the very real prospect of developing strategies to prevent and treat this disease.
Thornhill
M H
MH
Li
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D018925:Chemokines / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D018450:Disease Progression; D015700:HIV Envelope Protein gp41 / Q000502:physiology; D015658:HIV Infections / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology*; D015728:Receptors, HIV / Q000502:physiology*; D013491:Suppressor Factors, Immunologic
D018925:Chemokines; D015700:HIV Envelope Protein gp41; D019707:Receptors, Chemokine; D015728:Receptors, HIV; D013491:Suppressor Factors, Immunologic