title: Clearance of proteins from the air spaces following cardiogenic edema in sheep.
abstract: Studies on the clearance of instilled fluid and protein into the lungs of sheep show that fluid initially clears rapidly from the lungs resulting in an increase in an increase in air space protein concentrations. This is followed by a slower monoexponential clearance of proteins during the next few days. To determine whether the clearance of edema fluid follows the same time course as instilled fluid, alveolar edema was induced in 11 sheep by inflating a balloon in the left atrium for 2 h to increase left atrial pressure 35-40 cm H2O. Protein concentrations in the epithelial lining fluid (ELF) were monitored by performing single-cycle lavages immediately after deflation of the left atrial balloon, and again 3, 21, 48, and 96 h later. During the first 3 h of recovery, 44% of the fluid cleared and ELF protein concentrations rose from 7 +/- 2 to 19 +/- 6 mg/mL in the 7 sheep that recovered well. The ELF protein concentration in these sheep remained elevated for 48 h and then cleared at rates similar to that seen following instillation of proteins. We conclude that insights about mechanisms of clearance of edema fluid obtained from studies of clearance of instilled fluid are valid in cardiogenic edema, but the time course of the clearance differs between the two models.
authors.affiliation: Department of Cell Biology, University of Texas Health Center at Tyler 75710, USA. Peterson@UTHCT.edu
authors.forename: B T
authors.initials: BT
authors.lastname: Peterson
authors.forename: D E
authors.initials: DE
authors.lastname: Griffith
authors.forename: R W
authors.initials: RW
authors.lastname: Tate
mesh_terms: D000818:Animals; D016279:Atrial Function, Left / Q000502:physiology; D001992:Bronchoalveolar Lavage Fluid; D004848:Epithelium / Q000378:metabolism; D005122:Exudates and Transudates / Q000378:metabolism; D006333:Heart Failure / Q000150:complications* / Q000378:metabolism*; D007700:Kinetics; D008432:Mathematical Computing; D011506:Proteins / Q000378:metabolism* / Q000493:pharmacokinetics; D011650:Pulmonary Alveoli / Q000378:metabolism*; D011654:Pulmonary Edema / Q000209:etiology / Q000378:metabolism*; D012756:Sheep
chemical_list: D011506:Proteins