Quantitation and gompertzian analysis of tumor growth.
Human tumor xenografts in immune-deficient animals are used to establish tumor growth curves and for studying the effect of experimental therapy on tumor growth. In this review we describe a method for making serial measurements of tumor size in the nude mouse model as well as methods used to transform the experimental data into useful growth curves. A transformed Gompertz function is used as the basis for calculating relevant parameters pertaining to tumor growth and response to therapy. The calculations are facilitated by use of a computer program which performs the necessary calculations and presents the growth data in graphic form.
Rygaard
K
K
Institute of Molecular Pathology, University of Copenhagen, Denmark. kryg@pai.ku.dk
Spang-Thomsen
M
M
D000818:Animals; D002455:Cell Division / Q000502:physiology; D003627:Data Interpretation, Statistical; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy; D014183:Transplantation, Heterologous