VH-mediated mechanisms in normal and neoplastic B cell development.
Lymphomagenesis is viewed as a multistep process involving many independent transforming events. From several lines of investigation, it is speculated that in many cases, the early transforming events take place at a very early stage of B cell development. The focus of our laboratory is to understand the physiologic processes that ensure the development of normal B cells. It follows then that when one such process at an early stage of development is aberrant, the B cell will be prone to transformation events and dysregulated expansion.
Silberstein
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Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, USA. silbersl@mail.med.upenn.edu
Rao
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D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002454:Cell Differentiation / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics / Q000276:immunology*; D007135:Immunoglobulin Variable Region / Q000235:genetics / Q000276:immunology*
D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region