title: [IgA nephropathy in patients above 45 years of age. Clinical and morphologic analysis].
abstract: IgA nephropathy (IgAN) is considered as a disease of young men under 30 years of age, and is relatively uncommon in the elderly. It is thought, that the disease appears to have a more unfavourable prognosis in the elderly. The aim of the study was to evaluate the clinical and histological presentation of IgAN in patients under 45 (group I, n = 31, mean age = 28.3) and over 45 years of age (group II, n = 11, mean age = 48.6). Time between onset and diagnosis of IgAN was similar in both groups. Proteinuria/ 24 hand hypertension were significantly higher, gross hematuria was significantly lower in the older patients at the time of renal biopsy. Light microscope findings showed that severity of tubulointerstitial lesions, as well as glomerular sclerosis were more common in patients over 50 years of age, but mesangial proliferation in the younger ones. The study pointed out that factors that carry a poor prognosis, i.e. proteinuria, high blood pressure, tubulointerstitial damage were more commonly present in older patients. Prolonged follow-up is necessary to confirm this trend.
authors.affiliation: Pracowni Nefropatologii Katedry i Zakładu Patomorfologii Akademii Medycznej w Lodzi.
authors.forename: M
authors.initials: M
authors.lastname: Wagrowska-Danilewicz
authors.forename: M
authors.initials: M
authors.lastname: Danilewicz
authors.forename: M
authors.initials: M
authors.lastname: Szemraj
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D006417:Hematuria / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology
vernacular_title: IgA nefropatia u chorych powyzej 45 roku zycia. Analiza kliniczna i morfologiczna.