Evaluation of an avian-specific probiotic to reduce the colonization and shedding of Campylobacter jejuni in broilers.
Campylobacter jejuni has often been responsible for human gastroenteritis. Poultry have often been implicated as a source for these human infections. Intestinal colonization of C. jejuni in the chicken plays a role in carcass contamination during slaughter. Thus, reducing C. jejuni colonization in chickens can potentially reduce the incidence of C. jejuni infections in humans. The use of probiotics to competitively exclude the colonization of intestinal pathogens has been proposed for poultry. Hence, the purpose of this study was to evaluate the use of an avian-specific probiotic containing Lactobacillus acidophilus and Streptococcus faecium for reducing the shedding and colonization of C. jejuni in the chicken intestinal tract. Day-old chicks were randomly allocated into either a probiotic-treated group or a control group. The treated group was given probiotic from day 1 to day 3, and the control group was not given any probiotic. Six hours after the first oral administration of probiotics (treatment) or double distilled water (control), these chicks were challenged with C. jejuni. The frequency of the C. jejuni shedding was monitored until market age. Intestinal colonization was determined for the two experimental groups at slaughter. Results indicated that chickens given probiotics from day 1 to day 3 had a 70% reduction in the frequency of C. jejuni shedding in colonized chicks (P = 0.0001) and a 27% reduction in jejunal colonization in colonized chicks (P = 0.0001) at slaughter when compared with the control group. Thus, the use of the avian-specific probiotic containing L. acidophilus and S. faecium can reduce the colonization and frequency of fecal shedding of C. jejuni in market-aged broilers.
Morishita
T Y
TY
Department of Veterinary Preventive Medicine, Ohio State University, Columbus 43210, USA.
Aye
P P
PP
Harr
B S
BS
Cobb
C W
CW
Clifford
J R
JR
D000284:Administration, Oral; D000375:Aging / Q000473:pathology; D000818:Animals; D002169:Campylobacter Infections / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D016123:Campylobacter jejuni / Q000254:growth & development* / Q000302:isolation & purification; D002645:Chickens; D015169:Colony Count, Microbial; D018562:Disease Transmission, Infectious / Q000662:veterinary; D016984:Enterococcus faecium / Q000502:physiology*; D005243:Feces / Q000382:microbiology; D015994:Incidence; D007583:Jejunum / Q000382:microbiology / Q000473:pathology; D007779:Lactobacillus acidophilus / Q000502:physiology*; D011201:Poultry Diseases / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use*