title: [Demonstration of plaque development in multiple sclerosis using magnetisation transfer ratio images and protein spectroscopy with short echo time].
abstract: We investigated a patient with secondary progressive Multiple Sclerosis during an acute relapse and after 6 months using several Magnetic Resonance methods. Conventional Magnetic Resonance images demonstrated at the time of relapse a large gadolinium enhancing lesion. Using proton spectroscopy and Magnetisation Transfer images heterogeneous changes suggestive of oedematous swelling peripherally, and active myelin destruction centrally were demonstrated in the acute phase. After clinical recovery there was marked resolution of acute inflammatory Magnetic Resonance abnormalities and recovery of MR tissue parameters. In comparison with conventional Magnetic Resonance Imaging Magnetisation Transfer Imaging and Proton Spectroscopy provide improved characterisation of pathological changes in MS.
authors.affiliation: Multiple Sclerosis NMR Research Unit Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, Grossbritannien.
authors.forename: A
authors.initials: A
authors.lastname: Gass
authors.forename: C A
authors.initials: CA
authors.lastname: Davie
authors.forename: G J
authors.initials: GJ
authors.lastname: Barker
authors.forename: W I
authors.initials: WI
authors.lastname: McDonald
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009460:Neurologic Examination; D012008:Recurrence; D013116:Spinal Cord / Q000473:pathology*
vernacular_title: Demonstration der Plaqueentwicklung bei multipler Sklerose mittels Magnetisation-Transfer-Ratio-Bildern und Protonenspektroskopie mit kurzer Echozeit.