title: Myeloperoxidase activity in skin lesions. I. Influence of the loss of blood, depth of excoriations and thickness of the skin.
abstract: The measurement of the myeloperoxidase activity was used to quantify the acute granulocyte reaction. A 35% loss of blood resulted in a clear decrease of the myeloperoxidase activity at the edges of experimental incision wounds in rat skin in the first day after inflicting the wounds. After 12 h only about one-third and after 24 h about half of the activity observed in the wounds without the loss of blood remained. After 3 days however the activity had returned to the same level as in the wounds without any loss of blood. In very deep excoriations of the rat skin where only a narrow zone of the dermis was left about double the activity increase was observed after 12 and 24 h when compared to values observed in very superficial or moderate excoriations. When the same type of excoriations were made in both thin inguinal skin and thick dorsal skin then a much higher peroxidase activity increase was observed over 4, 12 and 24 h in the thin inguinal skin than in the excoriations made in the thick dorsal skin.
authors.forename: K
authors.initials: K
authors.lastname: Laiho
mesh_terms: D000818:Animals; D015415:Biomarkers; D005554:Forensic Medicine; D006098:Granulocytes / Q000378:metabolism*; D006470:Hemorrhage / Q000201:enzymology; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D009195:Peroxidase / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000201:enzymology / Q000293:injuries* / Q000473:pathology; D014950:Wounds, Penetrating / Q000201:enzymology* / Q000473:pathology
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D009195:Peroxidase