Helicobacter pylori promotes development of pepsinogen-altered pyloric glands, a preneoplastic lesion of glandular stomach of BALB/c mice pretreated with N-methyl-N-nitrosourea.
H. pylori is thought to be a stomach carcinogen. Since no experimental model has hitherto been established to clarify the relationship between H. pylori and stomach carcinogenesis, the effects of infection with the bacteria on experimental carcinogenesis in the glandular stomach of mice were investigated. BALB/c mice were given salty diet or N-methyl-N-nitrosourea (MNU) and administered broth culture of H. pylori. The incidence of pepsinogen-altered pyloric glands, considered as precancerous lesions, was increased in the H. pylori inoculated group pre-treated with MNU. The findings provide the new experimental model demonstrating the relationship between stomach cancer and H. pylori.
Shimizu
N
N
Laboratory of Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan. nshimizu@aichigw.aichi-cc.pref.aichi.jp
Kaminishi
M
M
Tatematsu
M
M
Tsuji
E
E
Yoshikawa
A
A
Yamaguchi
H
H
Aoki
F
F
Oohara
T
T
D000818:Animals; D005753:Gastric Mucosa / Q000201:enzymology* / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000201:enzymology* / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D008297:Male; D008770:Methylnitrosourea; D051379:Mice; D008807:Mice, Inbred BALB C; D010435:Pepsinogens / Q000378:metabolism*; D011230:Precancerous Conditions / Q000201:enzymology / Q000382:microbiology*; D017673:Sodium Chloride, Dietary
D010435:Pepsinogens; D017673:Sodium Chloride, Dietary; D008770:Methylnitrosourea