Bikunin and alpha 1-microglobulin in human zona pellucida and connective tissue.
The occurrence of bikunin and alpha 1-microglobulin was investigated in human ovary and Fallopian tubes. Bikunin and alpha 1-microglobulin are transcribed in the liver from a common gene. Bikunin immunoreactivity was detected in the zona pellucida. A positive reaction for bikunin was also observed in connective tissue of the oviduct. In addition, mast cells showed a more intense positive reaction than the surrounding connective tissue. Specific displaceable alpha 1-microglobulin immunoreactivity was revealed in the zona pellucida. The data suggest that bikunin and alpha 1-microglobulin are trapped in the zona pellucida.
Odum
L
L
Department of Clinical Biochemistry, Bispebjerg Hospital, University of Copenhagen, Denmark.
Nielsen
H W
HW
D000510:Alpha-Globulins / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism*; D003239:Connective Tissue Cells / Q000502:physiology; D005187:Fallopian Tubes / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins; D010053:Ovary / Q000166:cytology / Q000378:metabolism; D015842:Serine Proteinase Inhibitors / Q000378:metabolism*; D014360:Trypsin Inhibitor, Kunitz Soybean; D015044:Zona Pellucida / Q000378:metabolism*
D000510:Alpha-Globulins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; C109148:SPINT2 protein, human; D015842:Serine Proteinase Inhibitors; C016001:alpha-1-microglobulin; D014360:Trypsin Inhibitor, Kunitz Soybean