title: [The diagnostic value of anti-CMV and anti-HPV-B19 antiviral antibodies in studies on causes of recurrent abortions].
abstract: Presence of serum anti-cytomegalovirus (CMV) and anti-parvovirus B19 (HPV-B19) antibodies was studied in 11 women within the first day after consecutive spontaneous abortion in the second trimester of pregnancy and in the control group, consisting of 15 women in the second trimester of a normal pregnancy. Most of studied women manifested presence of serum IgG class anti-CMV antibodies (IgG-anti-CMV) and levels of the antibodies proved significantly higher in women following spontaneous abortions. The patients frequently demonstrated in parallel presence of serum IgG class anti-HPV-B19 antibodies. In one patient a generalised nonimmunological hydrops fetalis was disclosed and her serum contained IgM and IgG class antibodies against CMV as well as against HPV-B19. The results suggest that in majority of the studied women the spontaneous abortion might have resulted from fetal infection due to reactivation of chronic CMV infection in the course of pregnancy.
authors.affiliation: Zakładu Mikrobiologii Lekarskiej Instytutu Mikrobiologii i Chorób Zakaźnych Akademii Medycznej w Poznaniu.
authors.forename: A
authors.initials: A
authors.lastname: Szkaradkiewicz
authors.forename: P
authors.initials: P
authors.lastname: Pieta
authors.forename: T
authors.initials: T
authors.lastname: Tułecka
authors.forename: G
authors.initials: G
authors.lastname: Breborowicz
authors.forename: Z
authors.initials: Z
authors.lastname: Słomko
authors.forename: P
authors.initials: P
authors.lastname: Strzyzowski
mesh_terms: D000026:Abortion, Habitual / Q000175:diagnosis* / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis*; D002908:Chronic Disease; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D016732:Parvovirus B19, Human / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D011262:Pregnancy Trimester, Second; D012008:Recurrence
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G
vernacular_title: Wartość diagnostyczna przeciwciał przeciwwirusowych anty-CMV i anty-HPV-B19 w dochodzeniu przyczyn nawracajacych poronień.