title: Hemostatic treatment after tooth extraction in a patient with factor V deficiency.
abstract: BACKGROUND
  Factor V deficiency is a very rare hereditary coagulation disorder and tooth extraction in the patient with factor V deficiency has not been reported except in one case.
  
  
  METHODS
  A 38-year-old woman with factor V deficiency was referred for extraction of the impacted lower third molar. After intravenous administration of frozen fresh plasma (FFP) and recognition of an increase of factor V level from 1-31%, upper and lower third molars were extracted. Eighteen and 48 h after the extraction, factor V was intermittently supplemented by injection of 4 and 2 units of FFP, respectively, and factor V was maintained above 12%. To form fast coagula and to protect the wound, the lower extraction socket was filled with a fibrin glue composed of factor XIII and fibrinogen (Beriplast P) and a plastic splint was applied. The wound was healed and epithelized within 2 weeks after the extraction without any bleeding or infectious consequences.
  
  
  CONCLUSIONS
  Extraction in the patient with factor V hereditary deficiency is safely performed by both supplementation of factor V and application of local hemostasis.
authors.affiliation: Department of Oral Surgery, Kochi Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Tatemoto
authors.forename: T
authors.initials: T
authors.lastname: Osaki
mesh_terms: D000328:Adult; D017742:Dental Care for Chronically Ill / Q000379:methods*; D005166:Factor V Deficiency; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D006488:Hemostasis, Surgical; D006801:Humans; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D014081:Tooth Extraction / Q000009:adverse effects
chemical_list: D015718:Fibrin Tissue Adhesive