[Various clusters of immunoreactivity in the aged and their relation to HLA antigens and erythrocyte antigens].
In blood samples of members of the Berliner Altersstudie (BASE) (n = 427, 204 males, 223 females; mean = 85.2 years, range = 76-96 years, SD = 3.3 years), red cell, HLA-A, -B, -Cw and -Dr antigens were determined by standard methods. Lymphocyte reactivity was measured by 3H-thymidine uptake into DNA of lymphoblastic cells stimulated by 12 different mitogens and antigens. Cluster analysis, confirmed by t and F tests, defined 3 distinct clusters of lymphocyte reactivity. Clusters showed significantly different cumulations of 3 or more increased characteristic red cell and HLA antigens, and trends toward a decreased overall immunoresponsiveness in elder people. Like in middle-aged individuals, immunoresponsiveness in elder individuals can be dissected into at least 3 functionally different clusters which are not influenced by lymphocyte subsets or in vivo cell activation but by the patterns of both red cell and HLA antigens.
Wittmann
G
G
Blutbank, Abteilung Innere Medizin m.S. Hämatologie und Onkologie, Universitätsklinikum Rudolf Virchow, Berlin, Deutschland.
Zingsem
J
J
Weisbach
V
V
Zimmermann
R
R
Steinhagen-Thiessen
E
E
Huhn
D
D
Eckstein
R
R
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D001789:Blood Group Antigens / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000097:blood*; D015234:HLA-A Antigens / Q000097:blood; D015235:HLA-B Antigens / Q000097:blood; D015236:HLA-C Antigens / Q000097:blood; D006684:HLA-DR Antigens / Q000097:blood*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male
D001789:Blood Group Antigens; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens
Verschiedene Cluster der Immunreaktivität im Alter und ihre Relation zu HLA-Antigenen und erythrozytären Antigenen.