[Genetic polymorphisms of FABP2 and F13A1 loci in Han population].
OBJECTIVE
To find more STR loci usable in forensic medicine and understand the distribution of the genetic polymorphisms of two STR loci FABP2 and F13A1 in the Han population in Chengdu.


METHODS
EDTA-blood specimens were collected from 115 healthy unrelated Han individuals in Chengdu, DNA was extracted using Chelex method. The DNA samples were amplified by PCR technique, and the PAGE horizontal electrophoresis was used for typing of the PCR products.


RESULTS
The allele frequencies were FABP2*1:0.513,FABP2*2:0.096, FABP2*3:0.330, FABP2*4:0.052, FABP2*5:0.009, and 10 genotypes were observed in 115 individuals for FABP2; while for F13A1, the allele frequencies were F13A1*1:0.128, F13A1*2: 0.053, F13A1*3:0.288, F13A1*4:0.527, F13A1*5:0.004 and 10 genotypes were observed in 113 individuals. The result of test for Hardy-Weinberg equilibrium showed that the genotype distribution observed at FABP2 locus was correspondent with the expected.


CONCLUSIONS
FABP2 may be a useful marker for paternity test or personal indentification of biological stain. On the other hand, more studies need to be done to understand the polymorphism at F13A1 locus in Chinese population because a deviation from Hardy-Weinberg equilibrium has been observed in this Han population.
Li
Y
Y
Department of Forensic Biology, West China University of Medical Sciences, Chengdu, 610041 R. P. China.
Wu
J
J
Jin
Z
Z
Huang
F
F
Hou
Y
Y
D002352:Carrier Proteins / Q000235:genetics*; D002681:China / Q000208:ethnology; D005176:Factor XIII / Q000235:genetics*; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005838:Genotype; D006801:Humans; D007422:Intestines / Q000737:chemistry; D018996:Myelin P2 Protein / Q000235:genetics*; D009363:Neoplasm Proteins; D011110:Polymorphism, Genetic; D025521:Tumor Suppressor Proteins
D002352:Carrier Proteins; C493404:FABP2 protein, human; C107608:FABP7 protein, human; C493405:Fabp2 protein, mouse; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D005176:Factor XIII