title: Prospects for a prophylactic HPV vaccine: rationale and future implications for cervical cancer screening.
abstract: Cytologic screening in combination with ablative therapy has helped reduce cervical cancer mortality in the developed world. Despite the success of this approach, cervical cancer remains a major cause of death, especially among women with limited access to health care. Recognition that human papillomaviruses (HPVs) are the main etiologic agent in cervical cancer suggests that a prophylactic vaccine could reduce the incidence of HPV infection and, therefore, achieve cancer control with reduced reliance on costly screening programs. In this review, the rationale for developing a prophylactic HPV vaccine and the potential impact that vaccination would have on cervical cancer screening are discussed.
authors.affiliation: Department of Pathology, George Washington University Medical Center, Washington, D.C., USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Sherman
authors.forename: M H
authors.initials: MH
authors.lastname: Schiffman
authors.forename: H
authors.initials: H
authors.lastname: Strickler
authors.forename: A
authors.initials: A
authors.lastname: Hildesheim
mesh_terms: D005260:Female; D005544:Forecasting; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D027383:Papillomaviridae / Q000276:immunology*; D030361:Papillomavirus Infections / Q000517:prevention & control; D053918:Papillomavirus Vaccines; D015229:Sexually Transmitted Diseases, Viral / Q000517:prevention & control; D014412:Tumor Virus Infections / Q000517:prevention & control; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000821:virology; D014765:Viral Vaccines
chemical_list: D053918:Papillomavirus Vaccines; D014765:Viral Vaccines