title: [TSH-receptor blocking antibodies in juvenile thyrotoxicosis].
abstract: The case presented is a 12 year-old girl with hyperthyroidism due to juvenile Grave's disease, who during the course of treatment developed hypothyroidism due to TSH-receptor blocking antibodies, measured by bioassay. The bioassay used was performed on CHO-R cells measuring c-AMP. The role of radioreceptor assays and bioassays in measuring TSH receptor antibodies in hyper- and hypothyroid Graves' disease in discussed.
authors.affiliation: Odense Universitetshospital, børneafdeling H.
authors.forename: L H
authors.initials: LH
authors.lastname: Nielsen
authors.forename: B B
authors.initials: BB
authors.lastname: Jacobsen
authors.forename: E
authors.initials: E
authors.lastname: Fiore
mesh_terms: D000367:Age Factors; D019138:Antibodies, Blocking / Q000032:analysis; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology*; D008713:Methimazole / Q000008:administration & dosage / Q000009:adverse effects; D011989:Receptors, Thyrotropin / Q000276:immunology*; D013974:Thyroxine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D019138:Antibodies, Blocking; D013956:Antithyroid Agents; D011989:Receptors, Thyrotropin; D008713:Methimazole; D013974:Thyroxine
vernacular_title: TSH-receptorblokerende antistoffer ved juvenil tyreotoksikose.