title: [Effect of sex hormones on lipid peroxidation in the rat aorta].
abstract: The effect of sex hormones on lipid peroxidation (LPO) in the wall of the aorta of male rats was studied in vivo and in vitro. Female sex hormones (17 beta-estradiol and progesterone) inhibited LPO in the aorta: 17 beta-estradiol caused a maximum antioxidant effect at the beginning of its action, progester one during prolonged action. Testosterone had a marked prooxidant effect, activating lipid LPO in the aorta both in vivo and in vitro whatever its concentration and duration of incubation.
authors.affiliation: Russian State Medical University, Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Karachentsev
authors.forename: I A
authors.initials: IA
authors.lastname: Mel'chenko
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000378:metabolism; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D011374:Progesterone; D004958:Estradiol
vernacular_title: Perekisnoe okislenie lipidov v aorte krysy pri deĭstvii polovykh gormonov.