Lack of effect of suprachiasmatic infusion of a vasopressin antagonist on the circadian rhythm of wheel-running activity in rats.
Circadian patterns of wheel-running activity were studied in male Wistar rats before, during, and after continuous infusion of (Pmp1, Tyr(Me)2)-Arg8-vasopressin, a V1 receptor antagonist, in the suprachiasmatic region by means of Alzet mini-osmotic pumps. The lack of any significant effect on the pattern of wheel-running activity argues against a role for vasopressin in the generation of circadian rhythms by the suprachiasmatic nuclei.
Stoynev
A G
AG
Laboratory of Physiology, Transport Medical Institute, Sofia, Bulgaria.
Nagai
K
K
D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D006727:Hormone Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017483:Receptors, Vasopressin / Q000502:physiology; D013493:Suprachiasmatic Nucleus / Q000187:drug effects / Q000502:physiology*
D065092:Antidiuretic Hormone Receptor Antagonists; D006727:Hormone Antagonists; D017483:Receptors, Vasopressin; C089517:vasopressin, 1-(2-mercapto-2,2-(cyclopentamethylene)propionic acid)-2-(O-methyl)Tyr-8-Arg-; D001127:Arginine Vasopressin