title: [Effectiveness of goiter treatment with L-thyroxine in patients over 40].
abstract: OBJECTIVE
  We examined the effect of levothyroxine on thyroid size in elderly patients (an age > 40 y) with diffuse or nodular goitres.
  
  
  METHODS
  76 patients without relevant autonomy were treated with levothyroxine (2 micrograms/kg BW/d) over a period of 6-12 months. The elderly patients with diffuse goitres (group A, n = 33) and nodular goitres (group B, n = 21) were compared to 18-30 year old respective control groups (group C, n = 13, group D, n = 9). Laboratory parameters and ultrasonic determined goitre volumes were documented before levothyroxine treatment and after 6-12 months, respectively. All measured thyroid volume reductions were referred to the total goitre size.
  
  
  RESULTS
  After 6-12 months levothyroxine treatment a significant thyroid reduction was observed in group A (14.8%, p < 0.001), group C (16.0%, p < 0.05) and in group D (19.8%, p < 0.05), whereas in group B thyroid volume was nearly unchanged (4.5%). The result of group B differed from that of group D (p < 0.05).
  
  
  CONCLUSIONS
  These results suggest that levothyroxine can reduce diffuse goitres in elderly patients (group A), whereas in nodular goitres of elderly patients (group B) only a further thyroid growth can be provided.
authors.affiliation: Abteilung für Nuklearmedizin, Georg-August-Universität Göttingen, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Wollmann
authors.forename: J
authors.initials: J
authors.lastname: Meller
authors.forename: M
authors.initials: M
authors.lastname: Hüfner
authors.forename: W
authors.initials: W
authors.lastname: Becker
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D006042:Goiter / Q000097:blood / Q000188:drug therapy*; D006044:Goiter, Nodular / Q000097:blood / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000033:anatomy & histology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine
vernacular_title: Effektivität einer Strumatherapie mit L-Thyroxin bei Patienten über 40 Jahre.