title: Acute hepatitis during hypersensitivity syndrome due to midecamycin.
abstract: We report here the first case of symptomatic acute hepatic injury due to midecamycin in a 58-year-old man. The clinical picture was compatible with a hypersensitivity syndrome with cutaneous, renal and hepatic involvement. Liver eosinophil polynuclear infiltrate, hypereosinophilia and acute interstitial nephritis were consistent with the hypothesis of an immunoallergic mechanism.
authors.affiliation: Service d'Hépato-Gastroentérologie, Groupe hospitalier Pitié-Salpétrière, Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Thevenot
authors.forename: P
authors.initials: P
authors.lastname: Mathurin
authors.forename: F
authors.initials: F
authors.lastname: Martinez
authors.forename: J
authors.initials: J
authors.lastname: Moussalli
authors.forename: T
authors.initials: T
authors.lastname: Poynard
authors.forename: P
authors.initials: P
authors.lastname: Opolon
authors.forename: O
authors.initials: O
authors.lastname: Chosidow
mesh_terms: D000208:Acute Disease; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007933:Leucomycins / Q000009:adverse effects*; D008111:Liver Function Tests; D018942:Macrolides / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
chemical_list: D007933:Leucomycins; D018942:Macrolides; C026483:midecamycin