Value of clinical features in the diagnosis of enteric fever.
There is no objective data on the value of individual clinical symptoms or signs in the diagnosis of enteric fever in a febrile patient. The purpose of the study was to assess the value of some clinical and simple laboratory features in the diagnosis of enteric fever. One hundred & six patients with microbiologically confirmed enteric fever and 170 patients with other established febrile illnesses were included in the evaluation. History of stepladder pattern of rise of temperature, loose motions, relative bradycardia and coated tongue proved to be powerful markers of enteric fever with high specificity (100%, 94.71%, 94.71%, 94.12% respectively), positive and negative predictive values. Headache, hepatomegaly and splenomegaly were moderately powerful. ESR and WBC count appeared to have little value in the diagnosis of enteric fever. Pattern of onset and loose motions did not discriminate between typhoid and paratyphoid fever. Most of these patients had illness persisting beyond one week by which viral infections and infectious enterocolitides were largely excluded. Elucidation of power of these markers in distinguishing enteric fever from other febrile illnesses with the help of better designed prospective studies would lessen our dependence on expensive and time consuming laboratory investigations.
Haq
S A
SA
Department of Medicine, Institute of Postgraduate Medicine & Research, Dhaka.
Alam
M N
MN
Hossain
S M
SM
Ahmed
T
T
Tahir
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001799:Blood Sedimentation; D001831:Body Temperature; D001919:Bradycardia / Q000503:physiopathology; D002648:Child; D019411:Clinical Laboratory Techniques / Q000191:economics; D003967:Diarrhea / Q000503:physiopathology; D004760:Enterocolitis / Q000175:diagnosis; D005069:Evaluation Studies as Topic; D005260:Female; D005334:Fever / Q000503:physiopathology; D006261:Headache / Q000503:physiopathology; D006529:Hepatomegaly / Q000503:physiopathology; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010284:Paratyphoid Fever / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013163:Splenomegaly / Q000503:physiopathology; D013997:Time Factors; D014059:Tongue / Q000473:pathology; D014435:Typhoid Fever / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D014777:Virus Diseases / Q000175:diagnosis