title: [Recent data on the treatment of bovine hypodermyiasis using metrifonate (Neguvon) and ivermectin (Ivomec) in microdoses].
abstract: Large scale preventive treatments against bovine hypodermosis have been performed in the Canton of Grisons and in different Jura areas. Either Metrifonate (Neguvon 10% spot-on, Bayer AG) or Ivermectin "microdoses" (i.e. 0.1 ml Ivomec ad. inj-MSD AGVET-per animal) have been applied. The treatment of dairy cows with Neguvon at the then recommended dose (24 ml/animal) showed a low efficacy of 80%, without any correlation to the date of treatment. An increase of the dose to 36 ml/animal revealed an efficacy of 93%, while a weight-dependent dose of 6 ml/100 kg body weight reduced the warble infestation by 97.3% without any drug-related side-effects. The few observed side-effects-salivation and mild meteorism--are likely to be due to the destruction of Hypoderma lineatum larvae in the gullet of treated cows. No case of abortion was reported. The Ivomec--"microdose" applied to young animals or dry cows showed an efficacy > 99.8%. The available drugs would thus allow a quick and efficacious control of bovine hypodermosis, provided they would be used systematically and at an appropriate dose in endemic areas.
authors.affiliation: Laboratoire Pfister, Berne.
authors.forename: J L
authors.initials: JL
authors.lastname: Charbon
authors.forename: K
authors.initials: K
authors.lastname: Pfister
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005260:Female; D007000:Hypodermyiasis / Q000188:drug therapy / Q000662:veterinary*; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D014236:Trichlorfon / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007306:Insecticides; D007559:Ivermectin; D014236:Trichlorfon
vernacular_title: Données récentes sur le traitement de l'hypodermose bovine au moyen de métrifonate (Neguvon) et d'ivermectine (Ivomec) en microdoses.