A new antiplatelet diarylheptanoid from Alpinia blepharocalyx.
A new diarylheptanoid, 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (1), along with seven other known compounds, were isolated from the seeds of Alpinia blepharocalyx. Of these, compounds 1 and 3 showed strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood. Compound 3 also strongly inhibited ristocetin-induced platelet aggregation. Structures of these compounds were elucidated by spectroscopic and chemical means.
Doug
H
H
Bioscience Centre, National University of Singapore, Singapore.
Chen
S X
SX
Xu
H X
HX
Kadota
S
S
Namba
T
T
D002681:China; D036381:Diarylheptanoids; D006801:Humans; D066298:In Vitro Techniques; D007659:Ketones / Q000302:isolation & purification* / Q000494:pharmacology; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry
C110805:1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one; D036381:Diarylheptanoids; D007659:Ketones; D010636:Phenols; D010975:Platelet Aggregation Inhibitors