title: [Mechanisms of epileptogenesis and antiepileptic drugs].
abstract: Contemporary data about the mechanisms of epileptogenesis are reviewed. The role of the neuronal membrane and synapsis in the neurons changed by epilepsy is particularly pointed out. The concept of "the paroxysmal depolarizational shift" is defined. Role of some neurotransmitters in the mechanisms of epileptogenesis and their classifications into excitatory and inhibitory ones are also presented. It is pointed to a great variety of receptors for neurotransmitters as well as the role of calcium ions in mechanisms of epileptogenesis. A review of "classical" and new antiepileptic drugs is created and possible mechanisms of their effect are stated. The same antiepileptic medicaments are listed in a special table depending on the type of epilepsy in which they have effect. It is certain that during the last two decades electrophysiologic, biochemic and pharmacologic researchers have significantly improved the knowledge of the main occurrences responsible for epileptogenesis. However, a lot of facts are still doubtful.
authors.affiliation: Zavod za fiziologiju, Medicinski fakultet, Novi Sad.
authors.forename: D
authors.initials: D
authors.lastname: Filipović
authors.forename: V
authors.initials: V
authors.lastname: Ivetić
authors.forename: T
authors.initials: T
authors.lastname: Marcikić-Rabi
authors.forename: N
authors.initials: N
authors.lastname: Naumović
authors.forename: B
authors.initials: B
authors.lastname: Lazetić
authors.forename: K
authors.initials: K
authors.lastname: Bozić
authors.forename: A
authors.initials: A
authors.lastname: Kelemen
authors.forename: S
authors.initials: S
authors.lastname: Knezević
authors.forename: G
authors.initials: G
authors.lastname: Misić-Pavkov
mesh_terms: D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology
chemical_list: D000927:Anticonvulsants; D018377:Neurotransmitter Agents
vernacular_title: Mehanizmi epileptogeneze i antiepilepticki lekovi.