[Trends of genomic researches for drug discoveries].
In drug discoveries it becomes more important to search and validate target genes that control diseases. The development of novel strategies for functional genomics is indispensable for large scale analysis of human genes. (1) Recently, several research projects sequencing 5'-end of full-length enriched cDNA libraries were started because most of expressed sequence tags(ESTs) lack the 5'-end information of mRNA that is necessary for identifying the correct coding region. (2) New key technologies to quantify numerous gene expression levels simultaneously are now in progress. (3) Toward the functional analysis of unpredictable human genes, new strategies by using model animals (mouse, yeast, nematode) are under construction. Advances in molecular genetics and functional genomics will create new challenges for both drug discoveries and clinical evaluations.
Nemoto
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D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics; D002493:Central Nervous System Diseases / Q000235:genetics; D015195:Drug Design; D015870:Gene Expression; D015723:Gene Library; D016678:Genome; D016045:Human Genome Project; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D017422:Sequence Analysis, DNA; D016324:Sequence Tagged Sites