title: Action of chronic irradiation on the cytogenetic damage of human lymphocyte culture.
abstract: The action of chronic irradiation (dose rate 2.9 Gy/day) on human lymphocyte culture was investigated. Whole blood was irradiated at 37 degrees C. Aliquots (0.2 ml) of whole blood were cultivated by the standard method. A medium containing phytohemagglutinin was added immediately after irradiation. All structural chromosome- and chromatid-type changes were recorded. The experimental data showed that the conditions of irradiation of lymphocytes affected neither the background level of chromosome damage nor their radiosensitivity. The obtained dose-response curve of chromosome aberrations was described by a linear regression, which then became a plateau. There is no statistically significant difference between the results for the low doses (10-50 cGy) of chronic and acute radiation.
authors.affiliation: Laboratory of Cytogenetics, Institute of Theoretical and Experimental Biophysics, Pushchino, Moscow Region, Russia. zaichkina@venus.iteb.serpukhov.su
authors.forename: S I
authors.initials: SI
authors.lastname: Zaichkina
authors.forename: G F
authors.initials: GF
authors.lastname: Aptikaeva
authors.forename: O M
authors.initials: OM
authors.lastname: Rozanova
authors.forename: A K
authors.initials: AK
authors.lastname: Akhmadieva
authors.forename: E N
authors.initials: EN
authors.lastname: Smirnova
authors.forename: E E
authors.initials: EE
authors.lastname: Ganassi
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects* / Q000648:ultrastructure; D008297:Male