It may be the caffeine in Extra Strength Excedrin that is effective for migraine.
Strong
F C
FC
D000082:Acetaminophen / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology; D000700:Analgesics / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D002110:Caffeine / Q000032:analysis / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D017277:Drug Approval; D004338:Drug Combinations; D006207:Half-Life; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*
D000277:Adjuvants, Pharmaceutic; D000700:Analgesics; D004338:Drug Combinations; C110820:acetaminophen, aspirin, caffeine drug combination; D000082:Acetaminophen; D002110:Caffeine; D001241:Aspirin