Tools for visualization and integration of intermediate sequencing results in large disease gene discovery projects.
We describe two Java applets which are useful for insightful presentation of intermediate experimental data in gene discovery projects involving large scale sequencing. One of these applets provides a physical map of a genomic region and provides easy access to the second applet, which furnishes a detailed map of sequence contigs associated with clones on the physical map. In particular, the second applet displays all the known information about each contig, including the presence of exons, database homology 'hits', repetitive elements and other features; the graphics are linked to other World Wide Web pages, providing detailed information on each feature. These applets should be useful to other research groups working on large sequencing projects.
Rzhetsky
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Columbia Genome Center, Columbia University, 630 West 168th Street-BB 16-1611, New York, NY 10032, USA. andrey@genome2.cpmc.columbia.edu
Kalachikov
S
S
Ye
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Zhang
P
P
Russo
J J
JJ
D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D003195:Computer Communication Networks; D003360:Cosmids; D018076:DNA, Complementary; D016208:Databases, Factual; D005091:Exons; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics; D011381:Programming Languages; D012091:Repetitive Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA; D012984:Software
D018076:DNA, Complementary