title: Intrapartum amnioinfusion for meconium-stained liquor in developing countries.
abstract: BACKGROUND
  Intrapartum amnioinfusion (AI) has been reported to decrease perinatal mortality and morbidity in women with meconium-stained liquor. Such work has not previously been performed at King Edward VIII Hospital (KEH), in a developing country, where the incidence of meconium-stained liquor is said to be extremely high.
  
  
  OBJECTIVE
  To establish whether AI during the intrapartum period for meconium-stained liquor decreases Caesarean section rates for fetal distress and decreases perinatal morbidity.
  
  
  METHODS
  Informed consent was obtained from patients in labour who were 3-8 cm dilated, with meconium-staining of the liquor, grades I to III inclusive, and who had a normal cardiotocograph on presentation at term. Sixty patients were included in the trial; 30 had AI. The control group was managed by standard methods. The study group had an amnioinfusion of 0.9% normal saline at 15 ml/min under continuous cardiotocographic monitoring, until a volume of 11 was completed. This was repeated if delivery did not occur within 4 h.
  
  
  RESULTS
  The mean pH of umbilical arterial blood was significantly higher in the AI group (7.30 versus 7.23; P = 0.0029). In addition fewer patients in this group developed hypoxic ischaemic encephalopathy (0 versus 2 controls) or meconium aspiration syndrome (1 versus 4 controls). This was not statistically significant. Caesarean section for fetal distress was performed on fewer patients in the AI group (3 versus 7 controls), although this was not statistically significant.
  
  
  CONCLUSIONS
  These results demonstrate that amnioinfusion is an effective technique for improving the perinatal outcome of pregnancies complicated by meconium-stained liquor in labour. The decrease in Caesarean sections for fetal distress, though not statistically significant in this study, has clinical relevance. Furthermore, this study suggests that amnioinfusion is cost effective in a busy, high-risk labour ward unit and consequently should become standard practice in the management of meconium-stained liquor in labour.
authors.affiliation: MRC Pregnancy Hypertension Research Unit, University of Natal, Durban.
authors.forename: J
authors.initials: J
authors.lastname: Moodley
authors.forename: P
authors.initials: P
authors.lastname: Matchaba
authors.forename: A J
authors.initials: AJ
authors.lastname: Payne
mesh_terms: D000328:Adult; D000650:Amnion; D003906:Developing Countries; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007267:Injections; D008471:Meconium Aspiration Syndrome / Q000517:prevention & control*; D007744:Obstetric Labor Complications / Q000628:therapy*; D011247:Pregnancy; D011446:Prospective Studies; D012965:Sodium Chloride
chemical_list: D012965:Sodium Chloride