[Cytochrome P450*2D6 gene polymorphism in Chinese population].
OBJECTIVE
To demonstrate the cytochrome P450*2D6(CYP*2D6) gene polymorphism distribution in Chinese.


METHODS
The polymorphisms of CYP*2D6 gene in 100 Chinese people were studied with polymerase chain reaction and Xba I restriction fragment length polymorphic (RFLP) techniques.


RESULTS
The frequencies of CYP*2D6 gene A, B, D and E mutations were 1%, 6.5%, 0.5% and 1%, respectively; the genotypes of 29kb/29kb,44kb/29kb and 44kb/44kb Xba I RFLP were 38%, 46% and 13%, respectively. It was found that 12% of B mutations were linked with even though A and B mutations were mainly associated with 29kb/29kb genotype.


CONCLUSIONS
The frequencies of the four kinds of CYP*2D6 gene mutation in Chinese were lower than those of the European, but the frequency of Xba I 44kb allele was a little higher.
Tao
E
E
Department of Neurology, Sun Yat-sen University of Medical Sciences, Guangzhou, 510080 P. R. China.
Liu
Z
Z
Chen
B
B
Pan
X
X
D000328:Adult; D000368:Aged; D002681:China; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D019389:Cytochrome P-450 CYP2D6