title: Pathology of disappearing bone disease: a case report with immunohistochemical study.
abstract: A case of disappearing bone disease of the proximal femur is reported with histopathological and immunohistochemical studies. There was a densely packed cellular tissue, positive to endothelial antibodies, in areas of massive bone destruction. A more differentiated vascular tissue was present where trabecular cancellous or cortical bone was preserved with only focal zones of accelerated bone remodelling. The self-limited course correlates well with two phases of evolution of the histopathological lesions with neoplastic-like proliferation of endothelial cells corresponding to the rapid and massive bone destruction, and a later differentiation of the cells in mature vascular structures, but still with accelerated bone resorption which is partly compensated by appositional activity.
authors.affiliation: Clinica Ortopedica, 2a Facoltà di Medicine e Chirurgia, Università di Pavia, Varese, Italy.
authors.forename: U E
authors.initials: UE
authors.lastname: Pazzaglia
authors.forename: L
authors.initials: L
authors.lastname: Andrini
authors.forename: M
authors.initials: M
authors.lastname: Bonato
authors.forename: M
authors.initials: M
authors.lastname: Leutner
mesh_terms: D019644:Arthroplasty, Replacement, Hip; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology*; D005598:Fractures, Spontaneous / Q000209:etiology / Q000601:surgery; D006620:Hip Fractures / Q000209:etiology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010015:Osteolysis, Essential / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D011859:Radiography