Review article: Effector role of epithelia in inflammation--interaction with bacteria.
The common response to infection is infiltration of the affected tissue by inflammatory cells. It is now recognized that the epithelium plays a crucial role in this immunological process by producing an array of proinflammatory cytokines including interleukin-8, tumour necrosis factor-alpha, monocyte chemotactic protein-1, granulocyte-macrophage colony-stimulating factor, extractable nuclear antigen-78 and others. The response of the intestinal epithelium to bacterial pathogens is particularly intriguing because it is literally bathed by normal bacterial flora and bacterial components/products yet remains immunologically quiescent despite this potentially hostile environment. In contrast, when challenged by bacterial pathogens, intestinal epithelial cells exhibit a vigorous immunological response. Our laboratory has, therefore, focused on the immune response of intestinal epithelial cells when confronted by a specific bacterial pathogen, enteropathogenic Escherichia coli.
Hecht
G
G
Department of Medicine, University of Illinois at Chicago Medical Center, 60612-7323, USA.
Savkovic
S D
SD
D034961:Antigens, Nuclear; D001422:Bacterial Adhesion / Q000276:immunology; D002460:Cell Line; D016207:Cytokines / Q000096:biosynthesis*; D004847:Epithelial Cells / Q000276:immunology* / Q000648:ultrastructure; D004926:Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000276:immunology; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000276:immunology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D016328:NF-kappa B / Q000096:biosynthesis; D018375:Neutrophil Activation; D009687:Nuclear Proteins / Q000096:biosynthesis
D034961:Antigens, Nuclear; D016207:Cytokines; D016209:Interleukin-8; D016328:NF-kappa B; D009687:Nuclear Proteins