[Double-blind comparison of an apple pectin-chamomile extract preparation with placebo in children with diarrhea].
In a prospective, double-blind, randomised, multicentre, parallel group study, children (6 months to 5.5 years of age) with acute, non-complicated diarrhea received either a preparation containing apple pectin and chamomile extract (Diarrhoesan, n = 39) or placebo (n = 40) in addition to the usual rehydration and realimentation diet. At the end of three days of treatment, the diarrhea had ended significantly (p < 0.05) more frequently in the pectin/chamomile (33/39) than in the placebo group (23/40). Pectin/chamomile reduced the duration of diarrhea significantly (p < 0.05) by at least 5.2 h. The parents documented the well-being in a diary twice daily; in contrast to placebo, a trend of continuous improvement was observed in the pectin/chamomile group. The parents expressed their contentment more frequently (82%) with pectin/chamomile than with placebo (60%, not significant). There were no further differences between the treatment groups.
de la Motte
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Harrison Clinical Research, München.
Böse-O'Reilly
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Heinisch
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Harrison
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D000930:Antidiarrheals / Q000627:therapeutic use*; D002648:Child; D003967:Diarrhea / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010368:Pectins / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D011446:Prospective Studies
D000930:Antidiarrheals; D010936:Plant Extracts; D010368:Pectins
Doppelblind-Vergleich zwischen einem Apfelpektin/Kamillenextrakt-Präparat und Plazebo bei Kindern mit Diarrhoe.