Extracellular annexin II.
Annexin II belongs to a family of calcium-dependent, phospholipid binding proteins. Annexin II was first identified as an intracellular protein and attributed intracellular functions. Although it lacks a signal peptide and its mechanism of secretion is unknown, extracellular annexin II has recently been found in several tissues as both soluble and membrane-bound protein. Cell-surface annexin II has been identified as a receptor for a number of polypeptide ligands. Extracellular annexin II may be important in several biological processes, such as fibrinolysis, cell adhesion, ligand-mediated cell signaling and virus infection. These processes provide several possibilities for therapeutic approaches targeting extracellular annexin II, and future research should further illuminate the biology of this molecule.
Siever
D A
DA
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Erickson
H P
HP
D017306:Annexin A2 / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D002448:Cell Adhesion / Q000502:physiology; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D008958:Models, Molecular; D010960:Plasminogen Activators / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D015398:Signal Transduction / Q000502:physiology; D019063:Tenascin / Q000502:physiology
D017306:Annexin A2; D008024:Ligands; D008565:Membrane Proteins; D019063:Tenascin; D010960:Plasminogen Activators