title: On the synthesis of platelet-activating factor via acetylation of 1-alkyl-sn-glycero-3-phosphocholine. Formation of structural isomer of PAF in the presence of bases.
abstract: It has been shown that platelet-activating factor (PAF) specimens prepared via acetylation of 1-alkyl-sn-glycero-3-phosphocholine (lyso-PF) with acetic anhydride are heterogeneous. The contaminated compound was isolated and identified to be the structural isomer of PAF, 1-alkyl-3-acetyl-sn-glycero-2-phosphocholine (iso-PAF). It appeared, that iso-PAF is formed when performing the reaction in the presence of organic bases,but not under acid catalysis. The mechanism of iso-PAF formation is discussed.
authors.affiliation: M.V. Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Chupin
authors.forename: O V
authors.initials: OV
authors.lastname: Ostapenko
authors.forename: V N
authors.initials: VN
authors.lastname: Klykov
authors.forename: M V
authors.initials: MV
authors.lastname: Anikin
authors.forename: G A
authors.initials: GA
authors.lastname: Serebrennikova
mesh_terms: D000107:Acetylation; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor