title: Meropenem susceptibility of Neisseria meningitidis and Streptococcus pneumoniae from meningitis patients in The Netherlands.
abstract: In-vitro susceptibility of 299 Neisseria meningitidis and 157 Streptococcus pneumoniae strains from meningitis patients in The Netherlands in 1993 and 1994 to meropenem was determined using the Etest. Susceptibility to penicillin, ceftriaxone, and chloramphenicol was also determined. Rifampicin susceptibility was additionally tested for N. meningitidis. Of the meningococci, 4.3% were of intermediate resistance to penicillin and 0.3% were resistant to rifampicin. One pneumococcal isolate (0.6%) was of intermediate resistance to penicillin. All strains were susceptible to meropenem. We conclude that meropenem is in vitro highly active against N. meningitidis and S. pneumoniae.
authors.affiliation: The Netherlands Reference Laboratory for Bacterial Meningitis, Academic Medical Center, Amsterdam.
authors.forename: D
authors.initials: D
authors.lastname: van de Beek
authors.forename: E F
authors.initials: EF
authors.lastname: Hensen
authors.forename: L
authors.initials: L
authors.lastname: Spanjaard
authors.forename: J
authors.initials: J
authors.lastname: de Gans
authors.forename: R H
authors.initials: RH
authors.lastname: Enting
authors.forename: J
authors.initials: J
authors.lastname: Dankert
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D006801:Humans; D008585:Meningitis, Meningococcal / Q000382:microbiology; D008586:Meningitis, Pneumococcal / Q000382:microbiology; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000302:isolation & purification; D009426:Netherlands; D010406:Penicillins / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D013845:Thienamycins; D002701:Chloramphenicol; D002443:Ceftriaxone; D000077731:Meropenem