title: Potentially malignant epithelial oral lesions: discrepancies between clinical and histological diagnosis.
abstract: OBJECTIVE
  To evaluate the discrepancy index between the clinical and histological diagnosis and the prevalence of epithelial dysplasia and carcinoma in 45 patients with potentially malignant epithelial oral lesions (PMEL).
  
  
  METHODS
  We submitted 45 patients with PMEL to clinical examination and obtained a biopsy from each. The results of histological diagnosis were compared to the clinical diagnosis.
  
  
  RESULTS
  Clinical diagnosis showed that the most common PMEL was leukoplakia followed by lichen planus and by actinic cheilitis associated with leukoplakia. The most common site was the buccal mucosa. Histological diagnosis revealed that 46.7% of the PMEL were lichen planus. The discrepancy index between clinical and histological diagnosis was 24.4%. The higher discrepancy index occurred among leukoplakias. The prevalence of epithelial dysplasia and carcinoma was 17.8%.
  
  
  CONCLUSIONS
  We conclude that all PMEL should be submitted to a microscopic analysis because the discrepancy between clinical and histological diagnosis was present in a quarter of these lesions. Otherwise, the epithelial dysplasia and carcinoma were more frequent in the leukoplakias.
authors.affiliation: Department of Diagnosis and Surgery, School of Dentistry of Araraquara, UNESP, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Onofre
authors.forename: M R
authors.initials: MR
authors.lastname: Sposto
authors.forename: C M
authors.initials: CM
authors.lastname: Navarro
authors.forename: M E
authors.initials: ME
authors.lastname: Motta
authors.forename: E
authors.initials: E
authors.lastname: Turatti
authors.forename: R T
authors.initials: RT
authors.lastname: Almeida
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000453:epidemiology; D002613:Cheilitis / Q000175:diagnosis / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000175:diagnosis* / Q000453:epidemiology; D017676:Lichen Planus, Oral / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000175:diagnosis / Q000453:epidemiology; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000453:epidemiology; D011237:Predictive Value of Tests; D015203:Reproducibility of Results