title: A preliminary report: clinical effects of otic solution of ofloxacin in infantile myringitis and chronic otitis media.
abstract: Patients with infantile myringitis or chronic otitis media may refuse treatment when antibiotics are to be administered orally. The present study was undertaken to treat myringitis and chronic otitis media with an otic solution of non-ototoxic ofloxacin in 21 children aged 0-15 years. They consisted of eight normal children, four children operated on for microtia, and nine so-called handicapped children mainly with advanced hearing impairment and retardation in mental development, or eight children with myringitis and 13 children with chronic suppurative otitis media. Otic solution of ofloxacin was instilled into the ear twice daily, in the morning and evening, for 7 days or more, the treatment time being 10 min. With the causative pathogen completely eradicated in 14 patients and the bacterial count reduced in three patients and unchanged in two patients, the results of treatment with ofloxacin may be considered to be excellent.
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, University of Tokyo, Japan. kimikaga-tky@umin.u-tokyo.acjp
authors.forename: K
authors.initials: K
authors.lastname: Kaga
authors.forename: K
authors.initials: K
authors.lastname: Ichimura
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D015242:Ofloxacin / Q000627:therapeutic use*; D010034:Otitis Media with Effusion / Q000188:drug therapy*; D019999:Pharmaceutical Solutions; D012720:Severity of Illness Index; D014432:Tympanic Membrane
chemical_list: D000890:Anti-Infective Agents; D019999:Pharmaceutical Solutions; D015242:Ofloxacin