title: Dental maturity in children of short stature, with or without growth hormone deficiency.
abstract: The aim of this investigation was to study dental maturity in healthy prepubertal children of short stature (height<-2 SD), with or without growth hormone (GH) deficiency, compared to healthy controls. The GH-deficient group (GH level<10.0 microg/l) included 29 children (11 female, 18 male) with a mean age of 10.2+/-2.2 years. The GH non-deficient group consisted of 17 children (5 female, 12 male) with a mean age of 8.5+/-2.1 years. All the children were evaluated for serum concentrations of IGF-1, alkaline phosphatase (ALP), triiodthyronin (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), and fasting plasma insulin; height and bone age were also recorded. Dental maturity was determined from panoramic radiographs. The mean difference between the dental and chronological ages was -0.67+/-0.89 years in the GH-deficient group compared to 0.23+/-1.07 years in their controls: in the GH non-deficient group the difference was -0.95+/-0.82 years compared to controls 0.16+/-1.06 years in their controls. Compared to chronological age, both bone and dental age were lower in the GH-deficient and GH non-deficient groups. It is concluded that children of short stature, both GH-deficient and GH non-deficient. exhibit a delayed dental age compared to their chronological age- and sex-matched controls. A multiple stepwise regression analysis showed that the sitting height and GH level were the only significant factors associated with dental maturity.
authors.affiliation: Department of Pediatric Dentistry, School of Dentistry, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden. Larisa.Krekmanova@ofa.ki.se
authors.forename: L
authors.initials: L
authors.lastname: Krekmanova
authors.forename: J
authors.initials: J
authors.lastname: Carlstedt-Duke
authors.forename: M
authors.initials: M
authors.lastname: Brönnegård
authors.forename: C
authors.initials: C
authors.lastname: Marcus
authors.forename: E
authors.initials: E
authors.lastname: Gröndahl
authors.forename: T
authors.initials: T
authors.lastname: Modéer
authors.forename: G
authors.initials: G
authors.lastname: Dahllöf
mesh_terms: D000365:Age Determination by Skeleton; D000366:Age Determination by Teeth; D000375:Aging; D000469:Alkaline Phosphatase / Q000097:blood; D001827:Body Height; D016022:Case-Control Studies; D002648:Child; D005215:Fasting; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000503:physiopathology; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008137:Longitudinal Studies; D008297:Male; D009811:Odontometry; D011627:Puberty; D011862:Radiography, Panoramic; D012044:Regression Analysis; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007328:Insulin; D014284:Triiodothyronine; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013972:Thyrotropin; D000469:Alkaline Phosphatase; D013974:Thyroxine