[Structural elements of molecules of GTP-binding proteins and effectors mediating coupling between them].
Data available in literature on molecular mechanisms of the functional coupling of heterotrimeric G-proteins and small GTP-binding proteins (Ras-type) to effectors are analyzed. The segments of G-protein alpha-subunits which participate in formation of the effector-binding site are discussed. The induction of interaction between activated alpha-subunit and effector, following change of alpha-subunit nucleotide-binding site conformation as a result of GDP/GTP exchange is shown. The analysis of effector molecular determinants responsible for coupling to G-proteins are analyzed. The determinants are preferentially of the polycationic nature.
Shpakov
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AO
D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000737:chemistry; D000262:Adenylyl Cyclases / Q000737:chemistry; D019204:GTP-Binding Proteins / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry; D010741:Phospholipases A / Q000737:chemistry; D011485:Protein Binding; D018631:ras Proteins / Q000737:chemistry*
D010446:Peptide Fragments; D010741:Phospholipases A; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D019204:GTP-Binding Proteins; D018631:ras Proteins; D000262:Adenylyl Cyclases
Strukturnye élementy molekul GTP-sviazyvaniushchikh belkov i éffektorov, oposreduiushchie sopriazhenie mezhdu nimi.