title: Palliation of malignant dysphagia by laser therapy.
abstract: The outcome of 211 patients undergoing laser therapy as palliation for inoperable carcinoma of the esophagus is presented. The median age was 73 (range 44-97). The histology was adenocarcinoma for 127 patients and squamous-cell carcinoma for 84 patients. For 133 patients, laser was the only therapy while 56 patients had a combination of laser therapy and radiotherapy/chemotherapy. One patient underwent laser recanalization prior to resection while four patients had recurrence after resection treated by laser. Eleven patients underwent laser therapy for recurrent dysphagia after placement of an esophageal endoprosthesis. Eighteen patients died of procedure-related complications (i.e. 9% of patients and 2% of procedures). Of 32 procedures which perforated the tumour, 10 ended in death and the remaining patients were successfully treated conservatively. Good palliation was achieved for 170 patients (80%), while 19 patients underwent intubation after failure of laser therapy. Laser therapy failed to relieve dysphagia for 22 patients. The median survival was 20 weeks with the 1-year survival 12% and 2-year survival 4%; there were no significant differences in survival dependent on histology or administration of adjuvant radiotherapy or chemotherapy. Laser therapy provides a practical alternative to intubation in the treatment of malignant dysphagia for patients with unresectable esophageal carcinoma.
authors.affiliation: Department of Surgery, John Radcliffe Hospital, Oxford, UK.
authors.forename: A P
authors.initials: AP
authors.lastname: Savage
authors.forename: R J
authors.initials: RJ
authors.lastname: Baigrie
authors.forename: R A
authors.initials: RA
authors.lastname: Cobb
authors.forename: H
authors.initials: H
authors.lastname: Barr
authors.forename: M G
authors.initials: MG
authors.lastname: Kettlewell
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000538:Aluminum Silicates; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy; D002423:Cause of Death; D017024:Chemotherapy, Adjuvant; D003680:Deglutition Disorders / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D004939:Esophageal Perforation / Q000209:etiology / Q000628:therapy; D004940:Esophageal Stenosis / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery*; D004947:Esophagus; D006801:Humans; D007440:Intubation; D017075:Laser Coagulation / Q000009:adverse effects / Q000379:methods; D008875:Middle Aged; D009354:Neodymium; D010166:Palliative Care; D018714:Radiotherapy, Adjuvant; D012008:Recurrence; D015996:Survival Rate; D017211:Treatment Failure; D016896:Treatment Outcome; D015019:Yttrium
chemical_list: D000538:Aluminum Silicates; D009354:Neodymium; D015019:Yttrium