title: Esophagectomy for unsuccessful antireflux operations.
abstract: BACKGROUND
  Primary antireflux surgery provides excellent symptom relief in most patients. Unfortunately, the results of redo surgery are less predictable. In these patients, esophageal injury from long-standing reflux of gastric contents and operative trauma from previous failed antireflux procedures results in progressive deterioration in esophageal propulsion, poor clearance of reflux episodes, mucosal damage, and, in some cases, stricture formation. For the past 16 years, we have selectively used esophageal resection and replacement instead of another reoperation in these challenging patients.
  
  
  METHODS
  Seventeen patients with end-stage esophageal body dysfunction and one or more previously unsuccessful antireflux procedures underwent esophagectomy and reconstruction by colon interposition in 15 patients and jejunum interposition in 2 patients. The indications for esophagectomy rather than a redo antireflux procedure were a global loss of effective esophageal motility in 13 and a nondilatable stricture in four. Their outcome was compared with that of 32 patients with adequate motility and 18 with a similar global loss of motility who had a redo antireflux procedure. Perioperative complications after esophagectomy were recorded, and long-term outcome was assessed by means of a standardized questionnaire at a median of 7 years after the operation.
  
  
  RESULTS
  Patients with profound esophageal body dysfunction who underwent esophageal resection had outcomes similar to those with normal motility who underwent a redo antireflux procedure. Those with profound esophageal motility dysfunction who underwent a redo antireflux procedure had a worse outcome than those who underwent resection. Esophageal resection and replacement was performed without mortality or graft failure. All patients who underwent resection stated that their preoperative symptoms were relieved completely (n = 6) or improved (n = 10). Thirteen patients (81%) were able to eat three meals a day, and 12 patients (75%) enjoyed an unrestricted diet. Two thirds of the patients were at or above their ideal body weight, and 88% were fully satisfied with the outcome of the procedure.
  
  
  CONCLUSIONS
  Patients with end-stage esophageal body dysfunction who have had a previous unsuccessful antireflux procedure can be treated by esophageal resection with a high expectation of success.
authors.affiliation: Second Department of Surgery, University of Innsbruck, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Gadenstätter
authors.forename: J A
authors.initials: JA
authors.lastname: Hagen
authors.forename: T R
authors.initials: TR
authors.lastname: DeMeester
authors.forename: M P
authors.initials: MP
authors.lastname: Ritter
authors.forename: J H
authors.initials: JH
authors.lastname: Peters
authors.forename: R J
authors.initials: RJ
authors.lastname: Mason
authors.forename: P F
authors.initials: PF
authors.lastname: Crookes
mesh_terms: D000328:Adult; D000368:Aged; D016629:Esophagectomy / Q000009:adverse effects; D005260:Female; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D011795:Surveys and Questionnaires; D016896:Treatment Outcome