[Use of metformin in the management of adolescents with polycystic ovary syndrome].
Present study was designed to test that insulin resistance due to hyperinsulinism contribute to the clinical features of polycystic ovarian syndrome (POS). We studied 15 women wit POS who received Metformin 400 mg b.i.d during six months; blood levels of estradiol, testosterone (T), sexual hormone binding globulin (SHBG), insulin like growth factor-I (IGF-I) were determined. In response to treatment women exhibited decrement in serum levels of T as well as an increment, no significative, in both SHBG and IGF-I. Most of the patients showed reduction in body mass index and presented restoration of menstrual cycles. It is concluded that Metformin treatment exerts some metabolic effect which in turn induces some clinical improvement.
Zárate
A
A
Unidad de Investigación de Enfermedades Endocrinas, Hospital de Especialidades del Centro Médico Nacional, Instituto Mexicano del Seguro Social, México DF.
Hernández
M
M
Fonseca
M E
ME
Ochoa
R
R
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003627:Data Interpretation, Statistical; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D008687:Metformin
Empleo de metformín en manejo de adolescentes con el síndrome de ovarios poliquísticos.