Effects of oral administration of soybean lecithin transphosphatidylated phosphatidylserine on impaired learning of passive avoidance in mice.
Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was investigated for its effect on the impaired learning of a passive avoidance task by mice induced by scopolamine or cycloheximide. SB-tPS (240, 360, 480 mg/kg) administered orally significantly prolonged the step-through latency shortened by scopolamine. SB-tPS (240 mg/kg) administered orally also prolonged the step-through latency shortened by cycloheximide. These results suggest that the effect of SB-tPS on the impaired learning behavior may be related not only to the cholinergic system but also the serotonergic system.
Furushiro
M
M
Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan.
Suzuki
S
S
Shishido
Y
Y
Sakai
M
M
Yamatoya
H
H
Kudo
S
S
Hashimoto
S
S
Yokokura
T
T
D000284:Administration, Oral; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003513:Cycloheximide; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D037102:Lectins / Q000494:pharmacology*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D018727:Muscarinic Antagonists; D017288:Pain Threshold / Q000187:drug effects; D010718:Phosphatidylserines / Q000494:pharmacology*; D037121:Plant Lectins; D011500:Protein Synthesis Inhibitors; D012601:Scopolamine; D030262:Soybean Proteins; D013025:Glycine max; D010835:Phytohemagglutinins
D003513:Cycloheximide; D037102:Lectins; D018727:Muscarinic Antagonists; D010718:Phosphatidylserines; D037121:Plant Lectins; D011500:Protein Synthesis Inhibitors; D012601:Scopolamine; D030262:Soybean Proteins; C028824:soybean lectin; D010835:Phytohemagglutinins