[Hypotonic shock reaction as quality control marker for platelet concentrates].
Ten years of quality control in routine have led to a standardized platelet concentrate (PC). Mean parameters of the preparations are in the range of pH 6.7-7.3, (1.0-1.5) x 10(9)/ml platelet concentration, 80 x 10(9) platelets/PC and 2 x 10(7) leukocytes/PC. To judge the function of PCs, three methods were compared: the morphologic score, platelet aggregation tests, and the hypotonic shock reaction. The result is: The hypotonic shock reaction is a simple, well reproducible and sensitive method to judge the cell integrity.
Hauswirth
W A
WA
DRK-Blutspendedienst, Institut Münster, Deutschland.
Oehler
M
M
Rüther
G
G
Walther-Wenke
G
G
D001792:Blood Platelets / Q000166:cytology / Q000502:physiology; D001793:Blood Preservation / Q000592:standards*; D006801:Humans; D007038:Hypotonic Solutions; D007962:Leukocytes; D010974:Platelet Aggregation; D011786:Quality Control; D015203:Reproducibility of Results
D007038:Hypotonic Solutions
Die hypotone Belastbarkeit als Qualitätskontrollmarker für Thrombozytenkonzentrate.