title: The value of the prognostic factors in ovarian granulosa cell tumors.
abstract: The malignant potential of granulosa cell tumors (GCT) of the ovary is much debated. This study includes 18 patients with a diagnosis of GCT of the ovary. Clinical and pathologic data from patients were compared with flow cytometry ploidy, Ki-67 reactivity and p53 overexpression in order to determine their prognostic usefulness. There was no correlation between ploidy and stages or between ploidy and biological behavior. On the other hand, mitotic count, Ki-67 reactivity and p53 overexpression were associated with stages of disease, recurrent onset and survival. We believe that ploidy, Ki-67 and p53 should be considered important prognostic factors for GCT in association with the other more studied prognostic factors, even if no conclusions can be reached.
authors.affiliation: Institute of Gynaecology and Obstetrics, Padua University.
authors.forename: J
authors.initials: J
authors.lastname: Wabersich
authors.forename: M
authors.initials: M
authors.lastname: Fracas
authors.forename: S
authors.initials: S
authors.lastname: Mazzer
authors.forename: M
authors.initials: M
authors.lastname: Marchetti
authors.forename: G
authors.initials: G
authors.lastname: Altavilla
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D004273:DNA, Neoplasm; D005260:Female; D005434:Flow Cytometry; D006106:Granulosa Cell Tumor / Q000737:chemistry* / Q000175:diagnosis*; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000175:diagnosis*; D011003:Ploidies; D011379:Prognosis; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53