title: Therapeutic effects of supervised chlorhexidine mouthrinses on untreated gingivitis.
abstract: OBJECTIVE
  The aim of the present study was to test the presumptive therapeutic effect of chlorhexidine digluconate in a population with untreated gingivitis and presence of abundant calculus. SETTING AND STUDY DESIGN: Sixty subjects (approximately mean age of 23.4) were recruited from a knitting factory in the Province of Guangdong, People's Republic of China. By applying a double-blind clinical trial design the participants were divided into two groups (Test and Control) and matched according to their mean GI scores. The Test group (n = 20) was assigned to two daily mouthrinses for 6 days per week using 0.12% chlorhexidine digluconate (Peridex). The Control group (n = 40) rinsed twice daily with a placebo solution. All the rinsings were supervised and timed for 45 s. No attempt was made to influence the oral hygiene habits of the participants. Prior to and after 3 months of the supervised rinsing, plaque was scored using the Plaque Index system (PII), and gingivitis was assessed using the criteria of the Gingival Index system (GI). Calculus was scored according to the Calculus Surface Severity Index system (CSSI), and stain was also graded by the Discoloration Index system (DI).
  
  
  RESULTS
  After 3 months, the Test group (n = 13) showed significant reduction in mean PII, GI and percentage of gingival bleeding (GB%), while significant increases in mean DI were observed. The improvement in gingival health was observed at all regions with marked reduction in mean GI (from GI = 1.40 to 1.08) and GB% reduction by 24-52%. The proportion of GI = 2 was also reduced significantly from 50-36%. The Control group (n = 23) also showed a decrease in mean PII but significant increases in the mean GI and GB%. Intergroup comparison showed statistically significant differences between mean GI, percentage of gingival bleeding (GB%) and mean DI for the test and control groups after 3 months of supervised rinsing. However, there were no significant intergroup differences for mean PII.
  
  
  CONCLUSIONS
  In conclusion, there was a significant effect of chlorhexidine on gingivitis, although the effect may be too limited to assure prognostic benefits in the prevention of future disease progression.
authors.affiliation: University of Hong Kong, Faculty of Dentistry, Hong Kong.
authors.forename: E F
authors.initials: EF
authors.lastname: Corbet
authors.forename: J O
authors.initials: JO
authors.lastname: Tam
authors.forename: K Y
authors.initials: KY
authors.lastname: Zee
authors.forename: M C
authors.initials: MC
authors.lastname: Wong
authors.forename: E C
authors.initials: EC
authors.lastname: Lo
authors.forename: A W
authors.initials: AW
authors.lastname: Mombelli
authors.forename: N P
authors.initials: NP
authors.lastname: Lang
mesh_terms: D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003728:Dental Calculus / Q000188:drug therapy*; D003773:Dental Plaque / Q000517:prevention & control; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index
chemical_list: D009067:Mouthwashes; C010882:chlorhexidine gluconate; D002710:Chlorhexidine