Preparation, characterization, and in vitro release of ibuprofen from AI2O3/PLA/PMMA composites.
The preparation, characterization, and in vitro release of Ibuprofen from Al2O3, poly(L-lactic acid) (PLLA), and polymethylmethacrylate (PMMA) composites are described. The release process of the anti-inflammatory drug after the immersion of composites in a buffered solution is analyzed. The rate of Ibuprofen release is related to the crystalline or amorphous form of the drug. The presence of a ceramic component, alpha-Al2O3, and a biodegradable polymer, PLLA, facilitates both Ibuprofen crystallization and drug release. In addition, these composite systems modulate the release of the stereoisomers R(-) and S(+) of the drug.
Vallet-Regí
M
M
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, Madrid, Spain.
Granado
S
S
Arcos
D
D
Gordo
M
M
Cabañas
M V
MV
Ragel
C V
CV
Salinas
A J
AJ
Doadrio
A L
AL
San Román
J
J
D000537:Aluminum Oxide / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D002021:Buffers; D002851:Chromatography, High Pressure Liquid; D003188:Composite Resins / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry*; D007202:Indicators and Reagents; D019344:Lactic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D002021:Buffers; D003188:Composite Resins; D007202:Indicators and Reagents; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D019904:Polymethyl Methacrylate; D000537:Aluminum Oxide; D007052:Ibuprofen