Effect of very high single dose of cisplatinum and of radiation on the brain of the rabbit.
The importance of chemotherapy and radiotherapy for treating brain tumors, is well established. In a previous study, a rabbit's brain was treated with doses of up to 12 mg kg-1 of cisplatinum and 4000 cGy, without any morphological or pathological changes. The purpose of this study is to establish the effect of very high single doses of cisplatinum and radiation on the rabbit's brain, applied in 12, 16 and 18 mg kg-1, and 5000, 7500 and 8000 cGy, respectively. The general clinical and neurological condition of the rabbits was unaffected, but areas of alopecia and scalp ulcers appeared. Although these are very high doses of chemotherapy and radiotherapy, the histopathological and morphological examination of the rabbit's brain remained normal.
Walach
N
N
Department of Oncology, Assaf Harofeh Medical Center, Zerifin, Israel.
Lushkov
G
G
Nyska
A
A
Gur
R
R
Pollak
L
L
Schiffer
J
J
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D011817:Rabbits; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D011878:Radiotherapy / Q000009:adverse effects*
D011838:Radiation-Sensitizing Agents; D002945:Cisplatin