[Use of monoclonal antibodies for immunodiagnosis of lung cancer].
Fifty-three patients with lung cancer of different histological types and 72 with other lung diseases were examined by employing the panel containing 5 monoclonal antibodies (MAb) in the indirect immunofluorescence test (IFT). with tissue biopsy specimens, lung cancer could be revealed in 100% of patients with glandular carcinomas and adenocarcinoma of the lung, in 89% of those with small-cell carcinoma, and in 61% with squamous-cell carcinoma. With this, MAb reacted with cancer cellular membranes, by causing their fluorescence and failed to react and to cause the luminescence of inflammation cell membranes, the altered and intact bronchoalveolar epithelium in patients cancer and nontumoral diseases of the lung. IFT with MAb to lung cancerous surface antigens with the cells of tissue biopsy specimens may be a supplementation to cytological studies.
Romanova
R I
RI
Central NII of Tuberculosis PAMN, Moscow.
Gergert
V I
VI
Filippov
V P
VP
Goncharskaia
M A
MA
Evgushchenko
G V
GV
Sidorova
N F
NF
Gorelova
L A
LA
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007159:Immunologic Tests / Q000379:methods*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000276:immunology; D051379:Mice
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor
Ispl'zovanie monoklonal'nykh antitel dlia immunodiagnostiki raka legkikh.