title: Gammadelta T cells in host defense and epithelial cell biology.
abstract: Recent studies have demonstrated increased numbers of gammadelta T cells in a variety of human infectious as well as noninfectious diseases. In some cases gammadelta T cells could be shown to destroy infected or transformed cells. Advances in the identification of ligands recognized by gammadelta T cells and the development of animal model systems to study these cells in vivo should overcome some of the major obstacles currently preventing a better understanding of gammadelta T cell function in immune responses. As we gain this knowledge it may become possible to design therapeutic strategies exploiting unique properties of gammadelta T cells to promote more effective immunity.
authors.affiliation: The Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: R
authors.initials: R
authors.lastname: Boismenu
authors.forename: W L
authors.initials: WL
authors.lastname: Havran
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004848:Epithelium / Q000276:immunology; D006801:Humans; D007109:Immunity; D007239:Infections / Q000276:immunology*; D018448:Models, Immunological; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta