Preoperative prophylaxis for C1 esterase-inhibitor deficiency in patients undergoing oral surgery: a report of three cases.
C1-inhibitor deficiency, or hereditary angioedema, is a genetic disorder characterized by recurrent circumscribed, nonpruritic, nonpitting subepithelial edema. Minor trauma to the tissue, such as tooth extraction, can trigger life-threatening laryngeal edema. The use of fresh frozen plasma and/or danazol before treatment prevents angioedema attacks. A critical review of the treatment regimen and prophylaxis for C1-inhibitor deficiency is presented, and three new cases are described.
Peled
M
M
Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Technion Faculty of Medicine, Haifa, Israel.
Ardekian
L
L
Schnarch
A
A
Laufer
D
D
D000328:Adult; D000799:Angioedema / Q000188:drug therapy*; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency; D003613:Danazol / Q000008:administration & dosage*; D017742:Dental Care for Chronically Ill / Q000379:methods*; D004965:Estrogen Antagonists / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication; D014081:Tooth Extraction / Q000009:adverse effects
D003174:Complement C1 Inactivator Proteins; D004965:Estrogen Antagonists; D003613:Danazol