[3H] imipramine binding in brain samples from depressed suicides and controls: 5-HT uptake sites compared with sites defined by desmethylimipramine.
Using desmethylimipramine (DMI) defined and Na+ dependent [3H]imipramine binding, we have examined both 5-HT uptake sites and sites unrelated to 5-HT uptake, in frontal cortex, putamen and substantia nigra of suicides with a firm retrospective diagnosis of depression and matched controls. No differences were seen between antidepressant-free suicides and controls, although [3H]imipramine binding sites were significantly lower in putamen of the subgroup of non-violent suicides. The number of DMI defined [3H]imipramine binding sites was also significantly lower in putamen of antidepressant-treated suicides.
Lawrence
K M
KM
Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.
Kanagasundaram
M
M
Lowther
S
S
Katona
C L
CL
Crompton
M R
MR
Horton
R W
RW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D002423:Cause of Death; D003866:Depressive Disorder / Q000378:metabolism*; D003891:Desipramine / Q000378:metabolism*; D005260:Female; D005625:Frontal Lobe / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007099:Imipramine / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000737:chemistry / Q000378:metabolism; D011869:Radioligand Assay; D012701:Serotonin / Q000032:analysis*; D013378:Substantia Nigra / Q000737:chemistry / Q000378:metabolism; D013405:Suicide / Q000706:statistics & numerical data*; D014316:Tritium
D000928:Antidepressive Agents; D014316:Tritium; D012701:Serotonin; D007099:Imipramine; D003891:Desipramine