Preparation and use of morphine capsules in paediatric patients with burns.
Morphine is an analgesic agent used for the symptomatic relief of moderate to severe pain. The lack of oral paediatric form of morphine hydrochloride has led the pharmacy unit to develop capsules containing 1 mg of morphine. These capsules are prepared in conformity with G.M.P. and controlled by H.P.L.C. 73 burn children were treated in this study with pain suppression without adverse effects. This galenic form may be an adequate candidate for the management of paediatric patients because of its analgesic qualities and of numerous advantages.
Amirat-Combralier
V
V
Service de Pharmacie, CHU Nord, Marseille, France.
Jentile
B
B
Elias
R
R
Dejode
J M
JM
Lagier
P
P
Bues-Charbit
M
M
Balansard
G
G
D002056:Burns / Q000150:complications*; D002214:Capsules; D002648:Child; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D009020:Morphine / Q000008:administration & dosage* / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy* / Q000209:etiology
D002214:Capsules; D009020:Morphine