Cystoid macular edema and anterior uveitis associated with latanoprost use. Experience and incidence in a retrospective review of 94 patients.
OBJECTIVE
This study aimed to investigate the incidence of cystoid macular edema and anterior uveitis associated with the use of latanoprost.


METHODS
A retrospective review of patients treated with latanoprost in the authors' practice between September 1, 1996, and August 1, 1997, was performed.


METHODS
Ninety-four patients and 163 eyes were studied.


METHODS
Patients presenting with signs and symptoms of ocular inflammation while receiving latanoprost were noted, and their response to the discontinuation of the drug was recorded.


METHODS
The presence and degree of anterior uveitis and cystoid macular edema were measured.


RESULTS
Six (6.4%) of 94 patients (8 [4.9%] of 163 eyes) had anterior uveitis develop, and 2 (2.1%) of 94 patients (2 [1.2%] of 163 eyes) had cystoid macular edema develop while being treated with latanoprost.


CONCLUSIONS
Although latanoprost is an effective ocular-hypotensive agent, the authors' experience with the drug has shown a significant incidence of anterior uveitis and cystoid macular edema. To the authors' knowledge, this is the first study to report the incidence of both cystoid macular edema and anterior uveitis associated with latanoprost therapy. Treating physicians should be aware of these potential complicating side effects of latanoprost.
Warwar
R E
RE
Department of Ophthalmology, Wright State University School of Medicine, Dayton, Ohio 45429-3487, USA.
Bullock
J D
JD
Ballal
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D017889:Exfoliation Syndrome / Q000188:drug therapy; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D000077338:Latanoprost; D008269:Macular Edema / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000473:pathology
D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost