title: Effect of resistance exercise on free radical production.
abstract: The purposes of this investigation were to see whether free radical production changed with high intensity resistance exercise and, secondly, to see whether vitamin E supplementation would have any effect on free radical formation or variables associated with muscle membrane disruption. Twelve recreationally weight-trained males were divided into two groups. The supplement group (S) received 1200 IUs of vitamin E once a day (3 x 400 IU x d[-1]) for a period of 2 wk. The placebo group (P) received cellulose-based placebo pills once a day for the same period of time. Creatine kinase activity was significantly elevated between preexercise and immediately postexercise, 6 h postexercise, and 24 h postexercise for both groups. The placebo group also had a significant increase in creatine kinase activity at 48 h postexercise. There was a significant difference in creatine kinase activity between the groups at 24 h after exercise. Plasma malondialdehyde significantly increased from preexercise levels for the P group at 6 and 24 h postexercise. Plasma malondialdehyde concentrations significantly increased in the S group between preexercise and immediately postexercise levels. This study indicates that high intensity resistance exercise increases free radical production and that vitamin E supplementation may decrease muscle membrane disruption.
authors.affiliation: Department of Kinesiology, Noll Physiological Research Center, The Pennsylvania State University, University Park 16802, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: McBride
authors.forename: W J
authors.initials: WJ
authors.lastname: Kraemer
authors.forename: T
authors.initials: T
authors.lastname: Triplett-McBride
authors.forename: W
authors.initials: W
authors.lastname: Sebastianelli
mesh_terms: D000293:Adolescent; D000328:Adult; D003402:Creatine Kinase / Q000187:drug effects / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D018482:Muscle, Skeletal / Q000502:physiology; D014810:Vitamin E / Q000008:administration & dosage*; D014891:Weight Lifting / Q000502:physiology*
chemical_list: D005609:Free Radicals; D014810:Vitamin E; D008315:Malondialdehyde; D003402:Creatine Kinase