title: Pathogenesis of polycythaemia vera.
abstract: Polycythaemia vera (PV) is thought to result from clonal expansion of a transformed multipotent stem cell. Progenitors from patients with PV display abnormal responses to several growth factors, suggesting the presence of a defect in a signalling pathway common to different growth factors. A number of approaches are now focused on defining the molecular lesion or lesions. Identification of causal genes will be of considerable interest both to clinicians, who currently lack a specific and sensitive diagnostic test, and to scientists interested in fundamental issues of stem cell behaviour.
authors.affiliation: Department of Haematology, University of Cambridge, UK.
authors.forename: S
authors.initials: S
authors.lastname: Hinshelwood
authors.forename: A J
authors.initials: AJ
authors.lastname: Bench
authors.forename: A R
authors.initials: AR
authors.lastname: Green
mesh_terms: D006801:Humans; D011087:Polycythemia Vera / Q000209:etiology* / Q000235:genetics