title: Severe neurological complications in association with Epstein-Barr virus infection.
abstract: Involvement of the nervous system in infectious mononucleosis is common. About 50% have headache on presentation. Neck stiffness without meningitis is a frequent finding. Severe neurological complications are rare though, occurring in fewer than 0.5%. We describe two patients with unusual and severe neurological complications in association with serological evidence of EBV-infection: a 32-year old female developed a bilateral optic neuritis combined with a transverse myelitis and a 72-year old man developed mononeuritis multiplex, autonomic neuropathy and a salt-wasting nephropathy.
authors.affiliation: Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: E P
authors.initials: EP
authors.lastname: Corssmit
authors.forename: M A
authors.initials: MA
authors.lastname: Leverstein-van Hall
authors.forename: P
authors.initials: P
authors.lastname: Portegies
authors.forename: P
authors.initials: P
authors.lastname: Bakker
mesh_terms: D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000209:etiology*; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D007010:Hyponatremia / Q000209:etiology; D007244:Infectious Mononucleosis / Q000150:complications*; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D009188:Myelitis, Transverse / Q000209:etiology*; D009318:Natriuresis; D009443:Neuritis / Q000209:etiology*; D009902:Optic Neuritis / Q000209:etiology*; D010264:Paraplegia / Q000209:etiology; D014412:Tumor Virus Infections / Q000150:complications*