Accelerated breakdown and enhanced expression of c-Fos in the rat brain after noxious stimulation.
c-Fos expression was examined in rat brains at increasing times after a single noxious stimulus to one hindpaw. In some nuclei the expression peaked at 1 h and was gone by 6 h; in others it was biphasic with a larger peak appearing 6 h after the first. In other rats a second, contralateral stimulus was given at increasing times after the first, and c-Fos examined after a further 1.5 h. In some nuclei the first stimulus potentiated c-Fos expression caused by the second stimulus; in others the second stimulus erased any c-Fos still present from the first. Thus two similar stimuli can interact in very different ways in effecting c-Fos expression in different central nervous system nuclei, and rapid down-regulation might represent a novel type of interaction.
Redburn
J L
JL
School of Biomolecular and Biomedical Sciences, Griffith University, Nathan, Australia.
Leah
J D
JD
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D015536:Down-Regulation; D005786:Gene Expression Regulation / Q000502:physiology; D007031:Hypothalamus / Q000378:metabolism / Q000502:physiology; D008297:Male; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology; D010812:Physical Stimulation; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013788:Thalamus / Q000378:metabolism / Q000502:physiology; D013997:Time Factors
D016760:Proto-Oncogene Proteins c-fos