title: SELEX and the evolution of genomes.
abstract: The interrupted genome structures of complex multicellular organisms have most likely changed the evolution of the regulation of metabolism and development. Wasted intron sequences make regulation of gene expression in (for example) mammals appear to be unnecessarily complicated. The recent discoveries that globular RNA molecules are very much like the antigen-combining sites of antibodies suggest that intronic RNA may be used to help solve the problems raised by this complexity.
authors.affiliation: NeXstar Pharmaceuticals, Boulder, Colorado 80301, USA. lgold@nexstar.com
authors.forename: L
authors.initials: L
authors.lastname: Gold
authors.forename: B
authors.initials: B
authors.lastname: Singer
authors.forename: Y Y
authors.initials: YY
authors.lastname: He
authors.forename: E
authors.initials: E
authors.lastname: Brody
mesh_terms: D019143:Evolution, Molecular; D008040:Genetic Linkage; D016678:Genome; D007438:Introns; D008957:Models, Genetic; D011506:Proteins / Q000502:physiology; D012313:RNA / Q000502:physiology
chemical_list: D011506:Proteins; D012313:RNA