title: Ethanol-induced conditioned place aversion in rats: effect of interstimulus interval.
abstract: The purpose of this study was to examine the effect of interstimulus interval (ISI) on ethanol-induced place aversion in rats. Six groups of rats initially received four pairings of a distinctive floor stimulus (CS+) with ethanol (1 g/kg, I.P.) and four pairings of a different floor stimulus (CS-) with saline. Groups -30, -15, -10, -5, 0, and 5 were injected 30, 15, 10, 5, or 0 min before, or 5 min after exposure to the 5 min CS, respectively. After testing for place aversion, all groups were exposed to an additional set of conditioning trials using a higher dose of ethanol (1.5 g/kg). During the first test, only groups 0 and -15 exhibited conditioned place aversion. However, during the second test, all groups showed conditioned aversion except group -30. The results suggest that ethanol's aversive effects dissipate by 30 min postinjection or that it is more difficult to associate those effects with short-duration external stimuli at long backward intervals. In contrast to recent findings with mice, the direction of ethanol-induced place conditioning was not altered in rats exposed to different ISIs.
authors.affiliation: Department of Behavioral Neuroscience, and Portland Alcohol Research Center, Oregon Health Sciences University, 97201-3098, USA.
authors.forename: N M
authors.initials: NM
authors.lastname: Bormann
authors.forename: C L
authors.initials: CL
authors.lastname: Cunningham
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000097:blood / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012055:Reinforcement Schedule
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol