title: Perineal seeding of prostate cancer as the only evidence of clinical recurrence 14 years after needle biopsy and radical prostatectomy: molecular correlation.
abstract: Perineal needle tract seeding of prostate cancer is an unusual complication of perineal prostate biopsy. We report a case with the longest known interval from biopsy to perineal recurrence--14 years. The prostate-specific antigen did not become detectable until 12 years after biopsy and no other metastases were apparent, suggesting that the patient's perineal disease was an isolated recurrence. Immunohistochemical staining of the perineal recurrence and the original biopsy and prostate for the p53 tumor suppressor gene and bcl-2 oncogene proteins revealed rare/absent p53 expression but marked increased bcl-2 expression. This unusual molecular pedigree may help to explain this rare clinical scenario.
authors.affiliation: Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Moul
authors.forename: J J
authors.initials: JJ
authors.lastname: Bauer
authors.forename: S
authors.initials: S
authors.lastname: Srivastava
authors.forename: E
authors.initials: E
authors.lastname: Colon
authors.forename: C K
authors.initials: CK
authors.lastname: Ho
authors.forename: I A
authors.initials: IA
authors.lastname: Sesterhenn
authors.forename: D G
authors.initials: DG
authors.lastname: McLeod
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009366:Neoplasm Seeding; D010502:Perineum; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53