title: [Role of surgical splanchnicectomy in the treatment of pancreatic carcinoma].
abstract: Palliative surgical procedures offer considerable benefit for the patients with unresectable pancreatic cancer: surgical splanchnicectomy performed in conjunction with biliary-enteric by-pass offers good results as regard pain relief without increased morbidity and mortality. We treated 25 patients with unresectable pancreatic cancer by mean of biliary-enteric by-pass plus bilateral splanchnicectomy performed through different surgical approaches. In this series of patients postoperative mortality was nil, mean survival time was 7.2 months (range 3-14 months). Preoperatively, we assessed all patients as affected by visceral pain: Scott-Huskisson 10 mark-scale value in quantitative assessment of pain was equal or above the 7th mark in 87.5% of patients. One month later in the postoperative follow-up, 96% of the patients had a significant reduction in pain intensity from a preoperative median of 7 mark to a postoperative median of 1.5 mark (p = 0.0001). The mean period free of pain recurrence was 4.8 months. However, after 6 months only 46% of survivors were pain-free with such rate decreasing further to a 10% of survivors after 8 months. Nevertheless, the patients had around 70% of their survival span free of pain. We strongly believe that failure in relief of pain is due to a mistake in preoperative evaluation of the type of pain (somatic and not visceral, or both) and to the onset of somatic pain in the course of the disease rather than to surgical technical errors. Recurrence of pain has been considered inevitable in the biological progression of unresected cancer, and would be treated by combination of therapies, such as non steroidal anti-inflammatory drugs, transaortic coeliac plexus block, narcotics and cervical cordotomy.
authors.affiliation: Dipartimento di Scienze Chirurgiche Cattedra di Chirurgia Generale, Università degli Studi, Verona.
authors.forename: G L
authors.initials: GL
authors.lastname: Mangiante
authors.forename: A
authors.initials: A
authors.lastname: Ischia
authors.forename: C
authors.initials: C
authors.lastname: Iacono
authors.forename: F
authors.initials: F
authors.lastname: Nifosì
authors.forename: G
authors.initials: G
authors.lastname: Barzoi
authors.forename: E
authors.initials: E
authors.lastname: Montresor
authors.forename: A
authors.initials: A
authors.lastname: Acerbi
authors.forename: E
authors.initials: E
authors.lastname: Facci
authors.forename: P P
authors.initials: PP
authors.lastname: Aurola
authors.forename: G E
authors.initials: GE
authors.lastname: Serio
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D000368:Aged; D000714:Anastomosis, Surgical; D003135:Common Bile Duct / Q000601:surgery; D003627:Data Interpretation, Statistical; D004386:Duodenum / Q000601:surgery; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D005704:Gallbladder / Q000601:surgery; D006500:Hepatic Duct, Common / Q000601:surgery; D006801:Humans; D007583:Jejunum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010148:Intractable Pain / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D012008:Recurrence; D013153:Splanchnic Nerves / Q000601:surgery*; D013270:Stomach / Q000601:surgery; D013997:Time Factors
vernacular_title: Il ruolo della splancnicectomia chirurgica nel trattamento del carcinoma pancreatico.