title: Antagonism of atracurium-induced block in obese patients.
abstract: OBJECTIVE
  To investigate the relationship between total body weight (TBW) or body mass index (BMI) and atracurium reversal time.
  
  
  METHODS
  The study population comprised 25 patients with TBW < 80 kg and 25 patients with TBW > or = 80 kg anaesthetised with midazolam, thiopentone, fentanyl, nitrous oxide and halothane. Neuromuscular block was induced with 0.5 mg.kg-1 atracurium and maintained with doses of 0.15 mg.kg-1. Neuromuscular transmission was recorded using train-of-four (TOF) nerve stimulation and mechanomyography. Neostigmine, 0.07 mg.kg-1, was administered when the first twitch in TOF had recovered to 10% of control. Reversal time was defined as: time from administration of neostigmine until TOF ratio recovered to 0.70.
  
  
  RESULTS
  There was no difference in reversal time between patients with TBW < 80 kg (7.2 +/- 2.6 min, mean +/- SD), and patients with TBW > or = 80 kg (6.9 +/- 3.6 min). When patients were grouped according to BMI there was no difference in reversal time between groups with low BMI (6.9 +/- 2.6 min) or high BMI (7.1 +/- 3.6 min). There was, furthermore, no difference in reversal time between the 15 patients in the study population with the smallest TBW or BMI and the 15 patients with the greatest TBW or BMI. There was no correlation between TBW or BMI and reversal time.
  
  
  CONCLUSIONS
  When atracurium-induced neuromuscular block is antagonised with 0.07 mg.kg-1 neostigmine. TBW or BMI have no influence on reversal time.
authors.affiliation: Department of Anesthesia and Intensive Care, Odense University Hospital, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Kirkegaard-Nielsen
authors.forename: P
authors.initials: P
authors.lastname: Lindholm
authors.forename: H S
authors.initials: HS
authors.lastname: Petersen
authors.forename: I K
authors.initials: IK
authors.lastname: Severinsen
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D001279:Atracurium / Q000037:antagonists & inhibitors*; D015992:Body Mass Index; D001835:Body Weight; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D004558:Electric Stimulation; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006221:Halothane / Q000008:administration & dosage; D006801:Humans; D008874:Midazolam / Q000008:administration & dosage; D008875:Middle Aged; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D009388:Neostigmine / Q000627:therapeutic use; D019148:Neuromuscular Blockade; D009469:Neuromuscular Junction / Q000187:drug effects; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors*; D009609:Nitrous Oxide / Q000008:administration & dosage; D009765:Obesity / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects; D013874:Thiopental / Q000008:administration & dosage; D013997:Time Factors; D014459:Ulnar Nerve / Q000187:drug effects / Q000502:physiology
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D002800:Cholinesterase Inhibitors; D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; D009388:Neostigmine; D013874:Thiopental; D009609:Nitrous Oxide; D008874:Midazolam; D005283:Fentanyl; D006221:Halothane