title: The influence of acute poisoning with an organophosphate compound on the regulation of breathing and the respiratory system efficiency.
abstract: The female patient, aged 40, was admitted to the Department of Toxicology about fifteen hours after she had drunk 50 ml Basudin 25 EC (diazinon contents 25%) in a suicidal attempt. On admission the patients state was described as moderately severe (9 points). Starting with the first day after the poisoning, the functional state of the respiratory system was monitored. Ventilation efficiency was determined on the basis of the results from a flow-volume curve, spirometry and the measurements of the respiratory tract resistance (Rrs) in a computerised system Lungtest-MES company (Poland). Respiratory regulation was evaluated by means of synchronic measurements of the respiratory pattern and occlusion pressure. The results obtained from a respiratory pattern and P 0.1 were refereed to normal values. In the examination carried out directly after the poisoning slight obturation of the central bronchi and elevation in resistance of respiratory tract was noted. After a week, obturation was not noted and the resistance value was better. Also the respiratory pattern parameters and value of occlusion pressure were better. It seems that in this case the increase in resistance values in the respiratory tract should be related to the increased activity in the parasympathetic system. Basic, traditional spirometric even in the examination on the first day after the poisoning, were within normal limits, while the parameters of respiratory pattern, occlusion pressure and respiratory resistance were beyond the norm. The results obtained from the measurements of respiratory pattern parameters correlated well with the clinical condition of the patient and with the results of biochemical and enzymatic measurements.
authors.affiliation: Department of Clinical Toxicology, Collegium Medicum, Jagiellonian University, Kraków.
authors.forename: E
authors.initials: E
authors.lastname: Kolarzyk
authors.forename: D
authors.initials: D
authors.lastname: Szpak
authors.forename: D
authors.initials: D
authors.lastname: Pach
mesh_terms: D000328:Adult; D003976:Diazinon / Q000506:poisoning*; D005260:Female; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000187:drug effects*; D013406:Suicide, Attempted
chemical_list: D007306:Insecticides; D003976:Diazinon