title: Radical nephrectomy is still preferable in the treatment of localized renal cell carcinoma. A long-term follow-up study.
abstract: OBJECTIVE
  Due to the advances of radiological methods, an increased number of incidentally detected renal cell carcinomas is diagnosed. The reported excellent results of nephron-sparing surgery have promoted its application in patients with a normal contralateral kidney. However, the risk of local tumor recurrence and surgical complications after nephron-sparing surgery might be higher compared with radical nephrectomy.
  
  
  METHODS
  In 89 patients with localized renal cell carcinoma treated with radical nephrectomy, long-term renal function, morbidity, and survival were evaluated. The renal function was followed up regularly with serum creatinine measurements.
  
  
  RESULTS
  The cause-specific 5-year survival rate was 91.6%. There was neither local nor contralateral kidney tumor recurrence in any patient. Surgical complications were observed in 3% of the patients. Mean serum creatinine after the nephrectomy was 123 mumol/l without further increase during 10 years of follow-up.
  
  
  CONCLUSIONS
  Radical nephrectomy of localized renal cell carcinoma has low morbidity, excellent local tumor control, and a high survival rate. For patients with a normally functioning contralateral kidney the long-term renal function remained adequate. Based on these data, there is no convincing evidence justifying nephron-sparing surgery to be used routinely for patients with a normally functioning contralateral kidney.
authors.affiliation: Department of Urology and Andrology, Umeå University, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Ljungberg
authors.forename: F I
authors.initials: FI
authors.lastname: Alamdari
authors.forename: G
authors.initials: G
authors.lastname: Holmberg
authors.forename: T
authors.initials: T
authors.lastname: Granfors
authors.forename: M
authors.initials: M
authors.lastname: Duchek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007677:Kidney Function Tests; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009392:Nephrectomy; D011859:Radiography; D016019:Survival Analysis
chemical_list: D003404:Creatinine