title: Detection of numerical chromosomal changes in 20 malignant fibrous histiocytomas by FISH.
abstract: We investigated 20 malignant fibrous histiocytomas (MFHs) with the help of specific centromeric probes for chromosomes 1, 3, 4, 6, 8, 9, 12, 16, 17 and 18. The results show a broad variation in the number of signals per nucleus. However, tumors can be assigned into four groups: i) with mostly disomic clones, ii) with a high percentage of polysomic clones, iii) with a considerable amount of monosomic and nullisomic clones and iv) with a tendency in both directions. A gain of spots per nucleus takes place in 75-100% of the investigated tumors - the highest incidence occurring with respect to chromosome 3. A loss of spots per nucleus occurred in 20-60% of the tumors - predominantly with respect to chromosome 1.
authors.affiliation: Institute of Pathology, Martin-Luther-University Halle-Wittenberg, Magdeburger Str. 14, Halle/Saale, D-06097, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Korber
authors.forename: R
authors.initials: R
authors.lastname: Hinze
authors.forename: H
authors.initials: H
authors.lastname: Taubert
authors.forename: A
authors.initials: A
authors.lastname: Meye
authors.forename: P
authors.initials: P
authors.lastname: Wurl
authors.forename: M
authors.initials: M
authors.lastname: Bache
authors.forename: H J
authors.initials: HJ
authors.lastname: Holzhausen
authors.forename: H
authors.initials: H
authors.lastname: Dralle
authors.forename: F W
authors.initials: FW
authors.lastname: Rath
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002467:Cell Nucleus; D018385:Centrosome; D002869:Chromosome Aberrations; D002999:Clone Cells; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000145:classification / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured