title: [Demonstration of tissue lesions after intramuscular injection by determination of creatine kinase in blood].
abstract: Local muscle tissue damage by Terramycin-LA (20 mg/kg BM) injected at the neckmuscle was tested with seven pigs prepared with veneous catheters. Four of the pigs were used as the control group and were treated with an intramuscular injection of 0.9% NaCl-solution into the opposite neckmuscle later on. The tissue damage was clinically, pathologically and enzymatically examined. A significant rise of creatinkinase (CK) in bloodplasma up to 48 hours after intramuscular injection of Terramycin-LA proves to be a good indicator of local muscle damage. Based on enzymekinetic calculations it was possible to estimate the amount of muscle laesions after intramuscular injection of Terramycin-LA up to 13 g/100 kg BM and of NaCl-solution up to 0.5 g/100 kg BM respectively. The difference is significant.
authors.affiliation: Klinik für kleine Klauentiere und forensische Medizin und Ambulatorischen Klinik der Tierärztlichen Hochschule Hannover.
authors.forename: J
authors.initials: J
authors.lastname: Chavez Moreno
authors.forename: K
authors.initials: K
authors.lastname: Bickhardt
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood*; D007273:Injections, Intramuscular / Q000009:adverse effects / Q000662:veterinary*; D007700:Kinetics; D018482:Muscle, Skeletal / Q000473:pathology*; D010118:Oxytetracycline / Q000008:administration & dosage; D013552:Swine; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D003402:Creatine Kinase; D010118:Oxytetracycline
vernacular_title: Zum Nachweis von Gewebsläsionen nach intramuskulärer Injektion durch Bestimmung der Creatinkinase-Aktivität im Blutplasma.