Role of chronic inflammation in the promotion of prostatic hyperplasia in rats.
OBJECTIVE
Chronic prostatitis is a common histopathological finding in prostatectomized patients. A possible interrelationship between the presence of leukocyte exudate and the extent of the hyperplastic lesions has been suggested. The aim of the present study was to analyze the effect of the immunomodulator compounds, Complete Freund Adjuvant (CFA) and cyclosporin A (CsA), administered alone or together with citral on the induction and extent of rat prostatic hyperplasia.


METHODS
Adolescent Wistar rats (42 days old) were given citral alone or combined with CFA or CsA for one month. Semiquantitative analysis of the extent of the hyperplastic lesions was made with the histoscore protocol.


RESULTS
CsA did not induce hyperplastic changes or abolish the ability of citral to promote hyperplastic changes or to affect the extent of the lymphocytic exudate in the stroma. CFA itself, however, had a proliferative action on the prostatic epithelium, and it augmented the hyperplastic changes induced by citral and even induced atypical transformations of the acinar epithelium.


CONCLUSIONS
Immunoinflammatory stimulators might play a role in the prostatic epithelial cell growth and proliferation processes, most probably by modulation of the cytokine system.
Kessler
O J
OJ
Institute of Urology, Rabin Medical Center, Petah Tiqva, Israel.
Keisari
Y
Y
Servadio
C
C
Abramovici
A
A
D000080462:Acyclic Monoterpenes; D000818:Animals; D002455:Cell Division; D016572:Cyclosporine / Q000494:pharmacology*; D005620:Freund's Adjuvant / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007249:Inflammation; D008297:Male; D039821:Monoterpenes; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D011472:Prostatitis / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D000080462:Acyclic Monoterpenes; D007166:Immunosuppressive Agents; D039821:Monoterpenes; D013729:Terpenes; D014665:Vasodilator Agents; D016572:Cyclosporine; D005620:Freund's Adjuvant; C007076:citral