title: Phosphatases and tumorigenesis.
abstract: Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind. Currently, three phosphatases have been implicated in the etiology of tumors: protein phosphatase 2A, CDC25A/B, and PTEN (or MMAC1). Protein phosphatase 2A and PTEN behave as tumor suppressors, whereas CDC25A and -B act as oncogenes.
authors.affiliation: Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors.forename: R
authors.initials: R
authors.lastname: Parsons
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000201:enzymology* / Q000209:etiology; D009857:Oncogenes / Q000235:genetics; D051059:PTEN Phosphohydrolase; D010749:Phosphoprotein Phosphatases / Q000235:genetics* / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases; D054648:Protein Phosphatase 2; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000378:metabolism; D025521:Tumor Suppressor Proteins; D020687:cdc25 Phosphatases
chemical_list: D018797:Cell Cycle Proteins; D025521:Tumor Suppressor Proteins; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2; D010744:Phosphoric Monoester Hydrolases; D017027:Protein Tyrosine Phosphatases; D020687:cdc25 Phosphatases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D019204:GTP-Binding Proteins