[A sensitive method for detection of sympathomimetic amines in pentafluorobenzamide form in biological samples using gas chromatography].
A toxicological method of sensitive and specific confirmation of methamphetamine and other primary and secondary amines in biological samples after extractive perfluorobenzoylation is described. The method is based on the principle of gas chromatography with parallel specific nitrogen detection and electron capture detection. The other alternative is the gas chromatography combined with mass spectrometry in chemical ionization mode. The method described allows the detection of methamphetamine and amphetamine in urine in concentrations below 10 ng/ml.
Balíková
M
M
Ustav pro toxikologii a soudní chemii I. LF UK, Praha.
Kohlícek
J
J
Maresová
V
V
Rybka
K
K
D000662:Amphetamines / Q000652:urine; D001565:Benzoates; D002849:Chromatography, Gas; D006801:Humans; D008694:Methamphetamine / Q000652:urine; D015813:Substance Abuse Detection / Q000379:methods*; D013566:Sympathomimetics / Q000652:urine*; D005464:Fluorobenzenes; D005466:Fluorocarbons
D000662:Amphetamines; D001565:Benzoates; D008694:Methamphetamine; D013566:Sympathomimetics; C014737:pentafluorobenzoyl chloride; D005464:Fluorobenzenes; D005466:Fluorocarbons
Citlivý průkaz sympatomimetických aminů v biologických vzorcích ve formĕ pentafluorobenzamidů pomocí plynové chromatografie.