Epstein-Barr virus-induced T cell lymphoma in solid organ transplant recipients.
Epstein-Barr virus (EBV) infection in transplant recipients can lead to lymphomas termed posttransplantation lymphoproliferative disorders (PTLDs). Most PTLDs are malignancies of B lymphocytes and are linked to EBV infection, but the rare T lymphocyte PTLDs have been inconsistently linked to EBV infection. Although the B lymphocyte is the main host cell of EBV, it has been suggested that T lymphocytes may also become infected by EBV. A review of EBV-induced PTLDs at our institution identified one of 61 cases that was restricted to T lymphocytes. Of 36 cases of T cell PTLD identified through a literature review, 21 were investigated for the presence of EBV, and eight (38%) were documented to be EBV-induced. We compared the features of EBV-positive and EBV-negative T cell PTLDs and concluded that cases of EBV-positive T cell PTLD have some distinctive clinical features.
Dockrell
D H
DH
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
Strickler
J G
JG
Paya
C V
CV
D016027:Heart Transplantation / Q000009:adverse effects*; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects*; D016399:Lymphoma, T-Cell / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D014412:Tumor Virus Infections / Q000150:complications*