The renin-angiotensin system and vascular function. The role of angiotensin II, angiotensin-converting enzyme, and alternative conversion of angiotensin I.
The renin-angiotensin system has been implicated in vascular function and disease. Angiotensin-converting enzyme and angiotensin II are believed to be the most important components. However, alternative factors, such as angiotensin-I/II-(1-7) and chymase, have also been shown to be of significance in animal models. In this paper, we review some facts and provide additional proof for the functional significance of angiotensin-I/II-(1-7) and chymase in humans.
Roks
A
A
Department of Clinical Pharmacology, University of Groningen, The Netherlands.
Buikema
H
H
Pinto
Y M
YM
van Gilst
W H
WH
D000803:Angiotensin I / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D001921:Brain / Q000502:physiology; D053818:Chymases; D004730:Endothelium, Vascular / Q000502:physiology*; D006321:Heart / Q000502:physiology; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology*; D012697:Serine Endopeptidases / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology
D000804:Angiotensin II; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A; D012697:Serine Endopeptidases; D053818:Chymases