title: [Immunologic characteristics of women recurrent spontaneous abortion of unknown etiology. II. Characterization of humoral immunology].
abstract: The purpose of this study was to analyze the humoral immune response of non-pregnant women with unexplained recurrent spontaneous abortion (RSA). The study group was consisted of 117 nonpregnant women with RSA and 44 healthy, non-pregnant multigravidas (as a control). The following immunological parameters were analyzed in peripheral blood of two groups of women: the effect of autologous sera on proliferation of lymphocytes stimulated with phytohemagglutinin (PHA) or paternal lymphocytes (in mixed lymphocyte reaction--MLR), incidence of MLR-blocking antibodies (MLR-BAbs) incidence of antinuclear and anticardiolipin antibodies. The results show that women with RSA of unknown etiology differ in some parameters of immune response--higher incidence of antinuclear and anticardiolipin antibodies, absence of serum factors suppressing lymphocyte proliferation in response to PHA and paternal alloantigens--in comparison with nonpregnant normal multigravidas.
authors.affiliation: Katedry Połoznictwa i Ginekologii WAM, Centrum Zdrowia Matki Polki.
authors.forename: A
authors.initials: A
authors.lastname: Malinowski
authors.forename: K
authors.initials: K
authors.lastname: Zeman
authors.forename: J
authors.initials: J
authors.lastname: Wilczyński
authors.forename: E
authors.initials: E
authors.lastname: Głowacka
authors.forename: M
authors.initials: M
authors.lastname: Banasik
authors.forename: S
authors.initials: S
authors.lastname: Powierza
authors.forename: L
authors.initials: L
authors.lastname: Pokoca
authors.forename: M
authors.initials: M
authors.lastname: Szpakowski
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D000974:Antibodies, Antinuclear / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000032:analysis; D010298:Parity; D011247:Pregnancy; D012008:Recurrence
chemical_list: D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D007519:Isoantigens
vernacular_title: Immunologiczne odrebności kobiet z poronieniami nawykowymi o niewyjaśnionej etiologii. II. Charakterystyka stanu odporności humoralnej.