title: The expression of urokinase type plasminogen activator is a novel prognostic factor in dukes B and C colorectal cancer.
abstract: Urokinase type plasminogen activator (u-PA) secreted by cancer cells is considered to play a key role in promoting invasion and metastasis of cancer cells. This study was designed to evaluate the expression and prognostic value of u-PA in Dukes B and C colorectal cancer. u-PA expression was investigated in 57 Dukes B or C colorectal cancers using a monoclonal antibody against u-PA. u-PA expression was mainly observed on the cytoplasm of cancer cells, and was associated with relapse, especially hematogenous metastasis (p=0.025, the chi2 test). Patients with high u-PA expression had a lower rate of DFS (9/22 events) compared to those with low u-PA expression (6/35 events) (p=0.061, log-rank test). This study demonstrated that u-PA expression might be a novel prognostic factor in Dukes B and C colorectal cancer.
authors.affiliation: Department of Surgical Oncology, Osaka University, Medical School, 2-2 Yamadaoka, Suita City, Osaka 565, Japan.
authors.forename: S J
authors.initials: SJ
authors.lastname: Kim
authors.forename: E
authors.initials: E
authors.lastname: Shiba
authors.forename: F
authors.initials: F
authors.lastname: Tsukamoto
authors.forename: M
authors.initials: M
authors.lastname: Izukura
authors.forename: T
authors.initials: T
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Yoneda
authors.forename: Y
authors.initials: Y
authors.lastname: Tanji
authors.forename: Y
authors.initials: Y
authors.lastname: Kimoto
authors.forename: S I
authors.initials: SI
authors.lastname: Takai
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000628:therapy; D012189:Retrospective Studies; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*
chemical_list: D016685:Mitomycin; D014568:Urokinase-Type Plasminogen Activator; D005472:Fluorouracil