title: [Mortality during the first six years after cholecystectomy. A review of all cholecystectomies in women in Denmark during 1977-1981].
abstract: It has been a prevailing assumption that cholecystectomy patients by and large follow a pattern of survival similar to that of the normal population. This paper presents a population-based study of the long-term survival after cholecystectomy in order to reassess this assumption. Based on data available in the Danish National Hospital Register, the records of all Danish women who were operated between 1977 and 1981 were examined and studied up to six years subsequent to surgery. Cholecystectomy patients who were free of diagnosed cancer and who had no major co-surgery (n = 11,123) were compared to both hysterectomy patients and a sample of the female population. Adjusting for age and other covariates, patients with psychiatric hospital admissions prior to surgery experienced a threefold risk of dying within six years after surgery. Patients with prior somatic admissions and patient with acute admissions had a relative risk (RR) of about 1.5. Cholecystectomy patients had a significantly increased mortality when compared to hysterectomy patients, RR = 1.3 (1.1-1.6), and to the population sample. Heart diseases and cancer occurred significantly more often as causes of death among cholecystectomy patients when compared to hysterectomy patients, but our data suggest that the occurrence of many other causes of death may be increased among cholecystectomy patients as well. The authors concluded that cholecystectomy patients are subject to relatively higher levels of mortality than previously assumed in parts of the literature. Furthermore, the increase seems to be attributable to a multitude of causes of death. The most likely explanation of the excess mortality among cholecystectomy patients is that gallbladder patients are relatively fragile. Indeed, with this vulnerable group of patients the potential trauma of the surgical intervention itself needs careful consideration.
authors.affiliation: Københavns Universitet, Det Laegevidenskabelige Fakultet, Afdeling for Social Medicin.
authors.forename: T F
authors.initials: TF
authors.lastname: Anderson
authors.forename: H
authors.initials: H
authors.lastname: Brønnum-Hansen
authors.forename: T
authors.initials: T
authors.lastname: Jørgensen
authors.forename: C
authors.initials: C
authors.lastname: Roepstorff
authors.forename: A
authors.initials: A
authors.lastname: Loft
authors.forename: M
authors.initials: M
authors.lastname: Madsen
mesh_terms: D000328:Adult; D002423:Cause of Death; D002763:Cholecystectomy / Q000401:mortality*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000401:mortality; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D016019:Survival Analysis
vernacular_title: Dødeligheden i de første seks år efter kolecystektomi. Opgørelse af samtlige kolecystektomier blandt kvinder i Danmark i perioden 1977-1981.