title: Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness.
abstract: Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme-linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection.
authors.affiliation: Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599-7160, USA. jgilmore@css.unc.edu
authors.forename: J H
authors.initials: JH
authors.lastname: Gilmore
authors.forename: L F
authors.initials: LF
authors.lastname: Jarskog
authors.forename: J C
authors.initials: JC
authors.lastname: Lindgren
authors.forename: J P
authors.initials: JP
authors.lastname: McEvoy
authors.forename: H
authors.initials: H
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001927:Brain Diseases / Q000134:cerebrospinal fluid*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid*; D012559:Schizophrenia / Q000134:cerebrospinal fluid*
chemical_list: D009414:Nerve Growth Factors