A soy-derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat.
The ability of a soy-derived antiapoptotic fraction to inhibit methotrexate-induced gastrointestinal toxicity was examined. Male Sprague-Dawley rats treated with methotrexate were fed diets containing casein as a sole protein source or diets supplemented with a protein-phospholipid fraction isolated from soy flour. This soy fraction has also been shown to inhibit serum deprivation-induced programmed cell death (apoptosis) in the mouse embryonic C3H10T1/2 cell. Rats that received high doses of the soy-derived antiapoptotic fraction-supplemented diets experienced significantly less weight loss and diarrhea and better maintained their pretreatment appetite.
Funk-Archuleta
M A
MA
Division of Foods and Nutrition, University of Utah, Salt Lake City 84112, USA.
Foehr
M W
MW
Tomei
L D
LD
Hennebold
K L
KL
Bathurst
I C
IC
D000284:Administration, Oral; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects*; D001681:Biological Assay; D001835:Body Weight; D003967:Diarrhea / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D005493:Folic Acid Antagonists / Q000633:toxicity*; D015994:Incidence; D008297:Male; D008727:Methotrexate / Q000037:antagonists & inhibitors / Q000633:toxicity*; D019384:Nucleic Acid Synthesis Inhibitors / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D030262:Soybean Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D005493:Folic Acid Antagonists; D019384:Nucleic Acid Synthesis Inhibitors; D030262:Soybean Proteins; D008727:Methotrexate