[Increase of post-infection cold agglutinins after infection with Mycoplasma pneumoniae, varicella-zoster and rubella virus].
Cold agglutinins (CA) are observed during acute infections as transiently occurring postinfection autoantibodies directed against erythrocyte antigens. Distinct infectious agents induce CA of distinct specificity. A common association is the infection with Mycoplasma pneumoniae and the production of CA with anti-I specificity. In infections with varicella-zoster virus (VZV) and rubella virus (RV) a few cases of CA appearance are reported, all of them showing specificity for the Pr antigens. We examined the frequency of CA with the anti-Pr specificity in patients suffering from acute infections with VZV and RV (table 1). The known association of anti-I in about 70% of the cases with acute Mycoplasma pneumoniae infection is confirmed by our results. The occurrence of CA in infections with VZV and RV is a rare event. Based on published data, the specificity of these CA apparently is anti-Pr. Three of 5 anti-Pr examples were found in newborns with rubella embryopathy. Possibly, anti-Pr can be observed more frequently in these patients compared to adults.
Leo
A
A
Institut für Immunologie, Heidelberg.
Enders
G
G
Roelcke
D
D
D000328:Adult; D000373:Agglutinins / Q000032:analysis / Q000096:biosynthesis*; D003450:Cryoglobulins; D006562:Herpes Zoster / Q000097:blood* / Q000276:immunology; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D009177:Mycoplasma pneumoniae / Q000276:immunology; D011019:Pneumonia, Mycoplasma / Q000097:blood* / Q000276:immunology; D012409:Rubella / Q000097:blood* / Q000276:immunology; D012412:Rubella virus / Q000276:immunology; D013997:Time Factors
D000373:Agglutinins; D003450:Cryoglobulins; C029443:cold agglutinins
Häufigkeit postinfektiöser Kälteagglutinine bei Infektionen mit Mycoplasma pneumoniae, Varicella-Zoster- und Rubellaviren.