Inhibition of microsomal activation of aflatoxin B1 by 3-dehydroretinol and 3-dehydroretinyl palmitate.
Two vitamin A2 compounds (3-dehydroretinol and 3-dehydroretinyl palmitate) which are predominantly present in fresh water fish have been found to be very effective in inhibiting the microsome catalysed formation of DNA adduct by the carcinogen aflatoxin B1. The inhibition appears to be due to modulation of microsomal enzymes which activate the carcinogen. Such inhibition may suggest a potential chemopreventive role of these compounds against carcinogenesis induced by aflatoxin B1.
Aboobaker
V S
VS
Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Sarma
N
N
Goswami
U C
UC
Bhattacharya
R K
RK
D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors*; D000818:Animals; D002273:Carcinogens / Q000037:antagonists & inhibitors*; D004224:Diterpenes; D008862:Microsomes, Liver / Q000187:drug effects*; D051381:Rats; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D002273:Carcinogens; D004224:Diterpenes; C024366:vitamin A2; D014801:Vitamin A; C060513:3-dehydroretinol palmitate; D016604:Aflatoxin B1