title: [Factors associated with the degree of disability among patients of the Spanish Multiple Sclerosis Association of the Community of Madrid].
abstract: BACKGROUND
  Multiple sclerosis (MS) causes a degree of disability in young adults which hampers everyday activities. The aetiology and predisposing factors are unknown.
  
  
  OBJECTIVE
  To find the degree of disability (DD) and index of progression (IP) together with the possible associated prognostic factors in MS patients of the Spanish Multiple Sclerosis Association (AEDEM).
  
  
  METHODS
  Transverse design based on the population (AEDEM) by means of a representative sample (N = 158), taken randomly from those not suffering an exacerbation of MS. A telephone survey was carried out using the 'Minimum Dossier of Invalidity of MS' (eliminating variables concerning neurological dysfunction). The relationship between DD and IP, with different variables, was compared using parametric and non-parametric tests. Variables associated with the evolution of DD were measured in terms of the Odds Ratio.
  
  
  RESULTS
  The response rate was 150 (94.9%), 10 (6.7%) were rejected, giving a total of 140 patients. 55% of the patients considered themselves to be independent to some degree, in that they had no difficulty with everyday activities. Difficulty with walking was the 'most disabling problem' of 47.1%. Progression of the disorder (IP) depended on the frequency of exacerbations (r = 0.63). The variables associated with a raised DD are: suffer more than 5 exacerbations (OR: 3.73), have had the illness for more than 15 years (OR = 3.29) and a current age of over 35 years old (OR = 2.86).
  
  
  CONCLUSIONS
  The reduction in number and frequency of exacerbations or their prevention may reduce progression of the disorder and disability in daily life.
authors.affiliation: Centro Regional de Salud Pública, Consejería de Sanidad, Talavera de la Reina, Toledo.
authors.forename: J J
authors.initials: JJ
authors.lastname: Criado-Alvarez
authors.forename: R
authors.initials: R
authors.lastname: Munugarren
authors.forename: C
authors.initials: C
authors.lastname: Romo-Barrientos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis; D009103:Multiple Sclerosis / Q000453:epidemiology*; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology; D018709:Statistics, Nonparametric
vernacular_title: Factores asociados al grado de incapacidad de los enfermos de la Asociación Española de Esclerosis Múltiple de la Comunidad de Madrid.