title: Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I.
abstract: Saliva contains factors that inhibit infection with the human immunodeficiency virus type 1 (HIV-1) in vitro. One of these factors was recently identified as secretory leukocyte protease inhibitor (SLPI), a salivary protein which blocked HIV-1 infectivity of monocytes and primary T cells at physiologic concentrations (J Clin Invest 1995; 96: 456). Here, we confirm and extend the original report by demonstrating that SLPI protects primary monocytes and peripheral blood mononuclear cells against infection with HIV-1 Ba-L, IIIB and NL4-3. Thus, SLPI may provide a natural barrier against oral transmission of HIV-1.
authors.affiliation: UNC School of Dentistry, Chapel Hill 27599-7450, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Shugars
authors.forename: D L
authors.initials: DL
authors.lastname: Sauls
authors.forename: J B
authors.initials: JB
authors.lastname: Weinberg
mesh_terms: D000998:Antiviral Agents / Q000502:physiology; D015658:HIV Infections / Q000517:prevention & control; D015497:HIV-1 / Q000145:classification / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology*; D009000:Monocytes / Q000821:virology; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins / Q000494:pharmacology / Q000502:physiology*; D012471:Salivary Proteins and Peptides / Q000494:pharmacology / Q000502:physiology*; D053481:Secretory Leukocyte Peptidase Inhibitor; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology / Q000502:physiology*; D014774:Virulence / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; C506814:SLPI protein, human; D012471:Salivary Proteins and Peptides; D053481:Secretory Leukocyte Peptidase Inhibitor; D015842:Serine Proteinase Inhibitors