[Three levels of stress reaction of the immune system in an acute infectious process in children (facts and a hypothesis)].
Three variants of immune response (IR) in children with acute respiratory viral infections are determined and characterized in detail: the difference between these shows in the level of specific antibody production as well as in the non-specific immune suppression which is tested by lymphocyte blast transformation to phytogemagglutinin. According to our hypothesis, this phenomenon may by explained as a manifestation of three types of neuroendocrine IR regulation corresponding to three levels of immune system stress response. The proof of genetic and physiological factors involvement in the process of choosing any type of IR is adduced. The important role of ontogenetic development of cooperation between immune and nervous systems in IR variants formation is emphasized.
Zheleznikova
G F
GF
Scientific Research Institute of Children's Infections, Ministry of Public Health, St. Petersburg.
D000208:Acute Disease; D000914:Antibodies, Viral / Q000096:biosynthesis; D000918:Antibody Specificity / Q000276:immunology; D002648:Child; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D015213:Neuroimmunomodulation / Q000276:immunology; D012141:Respiratory Tract Infections / Q000276:immunology*; D013312:Stress, Physiological / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
D000914:Antibodies, Viral
Tri urovnia stress-reaktsii immunnoĭ sistemy pri ostrom infektsionnom protsesse u deteĭ (fakty i gipoteza).