[The treatment of rats experimentally infected with Strongyloides venezuelensis by orally administered ivermectin].
Strongyloides venezuelensis experimental infection in rats was treated by two different oral preparations of ivermectin, 0.2 mg/kg. One was a human formula used by WHO in the treatment of onchocerciasis; the other was a veterinary preparation. Adult worms and larvae were evaluated. The human formulation cleared both forms in 59.3% (adult worms) and 73.0% (larvae), whereas the veterinary one cleared 98.0% and 84.2%, respectively. The antilarval action is very useful when treating systemic strongyloidiasis.
Amato Neto
V
V
Laboratório de Investigação Médica-Parasitologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, SP, Brasil.
Carignani
F L
FL
Matsubara
L
L
Braz
L M
LM
D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007422:Intestines / Q000469:parasitology; D007559:Ivermectin / Q000008:administration & dosage*; D007814:Larva / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013321:Strongyloides / Q000187:drug effects; D013322:Strongyloidiasis / Q000188:drug therapy* / Q000469:parasitology; D013997:Time Factors
D000969:Antinematodal Agents; D007559:Ivermectin
Tratamento de ratos, experimentalmente infectados pelo Strongyloides venezuelensis, através da ivermectina administrada por via oral.