[The evaluation of a method for determining apolipoproteins as a sensitive indicator in assessing lipid metabolic disorder in a population at risk for essential arterial hypertension (EAHT)].
The increased efficiency of epidemiological screening tests in determining the prevalence of risk factors carriers required the use of highly sensitive markers able at detecting early, in reversible stages, the disturbances in the lipid metabolism genetically induced or acquired during lifetime, known as major risk factors for essential hypertension and other cardiovascular diseases. The authors report the preliminary results of some investigations on the predictive value of apolipoproteins. Immunokits manufactured by BioMérieux--France were used. In 50 admitted patients with essential hypertension and family history of risk, high levels of apoA1 and apoB were recorded although cholesterol and other biological markers were within the normal. At the same time, in our case the apoB/apoA ratio was supraunitary, fact proving the validity of the method.
Azoicăi
D
D
Catedra de Epidemiologie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Ivan
A
A
Gheorghiţă
N
N
Pavel
M
M
Jerca
L
L
Iacobovici
A
A
Ungureanu
G
G
Stoica
O
O
Hurjui
J
J
D001053:Apolipoproteins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015995:Prevalence; D011933:Reagent Kits, Diagnostic; D012307:Risk Factors; D012680:Sensitivity and Specificity
D001053:Apolipoproteins; D015415:Biomarkers; D008055:Lipids; D011933:Reagent Kits, Diagnostic
Validarea metodei de dozare a apoliproproteinelor ca indicator sensibil de apreciere a dismetabolismului lipidic la populaţia cu risc pentru hipertensiunea arterială esenţială (HTAE).