Inhibitory effect of 1alpha-hydroxyvitamin D3 on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastrointestinal carcinogenesis in Wistar rats.
The effect of 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) on gastrointestinal carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was investigated in male Wistar rats. After oral treatment with 0.01% MNNG for 24 weeks, rats were given 0.04 microg of 1alpha(OH)D3 or its vehicle by gastric intubation three times a week for 24 weeks. The incidence of gastrointestinal tumors was 16/30 (53%) in rats treated with MNNG alone, 16/30 (53%) in those treated with MNNG plus vehicle and 8/30 (27%, P < 0.05) in those treated with MNNG plus 1alpha(OH)D3. The number of tumors per rat in the group treated with MNNG plus 1alpha(OH)D3 was half those in the control groups (P < 0.05). Results indicated that a non-hypercalcemic dose of 1alpha(OH)D3 had an inhibitory effect on MNNG-induced duodeno-intestinal carcinogenesis.
Kawaura
A
A
Second Department of Pathology, School of Medicine, The University of Tokushima, Japan.
Tanida
N
N
Nishikawa
M
M
Yamamoto
I
I
Sawada
K
K
Tsujiai
T
T
Kang
K B
KB
Izumi
K
K
D000818:Animals; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008297:Male; D008769:Methylnitronitrosoguanidine; D051381:Rats; D017208:Rats, Wistar
D006887:Hydroxycholecalciferols; D008769:Methylnitronitrosoguanidine; C008088:alfacalcidol