title: Effect of simvastatin on ischemic signs and symptoms in the Scandinavian simvastatin survival study (4S).
abstract: In patients participating in the Scandinavian Simvastatin Survival Study, cholesterol lowering with simvastatin reduced the incidence of carotid bruits and cerebrovascular events as well as new-onset or worsening of angina pectoris and intermittent claudication. These effects suggest that simvastatin may have a general antiatherosclerotic effect not limited to the coronary bed.
authors.affiliation: Aker Hospital, Oslo, Norway.
authors.forename: T R
authors.initials: TR
authors.lastname: Pedersen
authors.forename: J
authors.initials: J
authors.lastname: Kjekshus
authors.forename: K
authors.initials: K
authors.lastname: Pyörälä
authors.forename: A G
authors.initials: AG
authors.lastname: Olsson
authors.forename: T J
authors.initials: TJ
authors.lastname: Cook
authors.forename: T A
authors.initials: TA
authors.lastname: Musliner
authors.forename: J A
authors.initials: JA
authors.lastname: Tobert
authors.forename: T
authors.initials: T
authors.lastname: Haghfelt
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000150:complications / Q000517:prevention & control*; D018450:Disease Progression; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007511:Ischemia / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D019821:Simvastatin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000960:Hypolipidemic Agents; D019821:Simvastatin