Synergistic effects of triterpenic compounds with prostaglandin A1 on vaccinia virus infected L929 cells.
Triterpenic compounds, such as glycyrrhizic acid (GRa) and carbenoxolone (CBX), have a synergistic effect with prostaglandin A1 on the inhibition of vaccinia virus (VV) replication in L929 cells. The fractional inhibitory concentration (FIC) values for GRa and CBX were 0.5 and 0.25, respectively. In the supernatant of triterpene treated cells, increased production of some prostaglandins was shown, whilst cell-associated prostaglandins and prostaglandins of the A series were only slightly influenced by the presence of triterpenes. From these findings there is no evidence that prostaglandin production and metabolism could be involved in the antiviral activity of triterpenes.
Lampis
G
G
Sezione di Microbiologia Applicata, Istituto di Medicina Interna, Universita' di Cagliari, Italy.
Ingianni
A
A
Pompei
R
R
D000818:Animals; D002229:Carbenoxolone / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002522:Chlorocebus aethiops; D004357:Drug Synergism; D019695:Glycyrrhizic Acid / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D015394:Molecular Structure; D011453:Prostaglandins / Q000096:biosynthesis; D011454:Prostaglandins A / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects*; D014709:Vero Cells
D011453:Prostaglandins; D011454:Prostaglandins A; D019695:Glycyrrhizic Acid; D002229:Carbenoxolone; C100573:prostaglandin A1