Interactions between amphotericin B and nitroimidazoles against Candida albicans.
This work proved that nitroimidazole antiprotozoal agents, such as metronidazole, ornidazole, secnidazole and tinidazole, in concentrations of up to 64 micrograms ml-1 did not present any antifungal activity against 17 strains of Candida albicans. The combination of each drug with amphotericin B showed the occurrence of variable interactions according to the studied strain. Promising results were observed based on synergistic and additive interactions of the polyene with the metronidazole; the inhibitory and lethal activities of the drugs were potentiated against all strains in concentrations reachable in vivo.
Cury
A E
AE
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brasil.
Hirschfeld
M P
MP
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000494:pharmacology*
D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D009593:Nitroimidazoles; D000666:Amphotericin B