title: [The effect of laryngectomy on the fibrinolysis process in the blood of patients with laryngeal neoplasms].
abstract: Some data in the literature indicate on the influence of different kind of surgery on the fibrinolytic process. Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1)--play important role in regulation of fibrinolysis. The aim of our work was to evaluate the influence of laryngectomy on fibrinolytic potential in the blood of operated patients with larynx carcinoma. Study group consisted of 20 men aged 42-75 years old with larynx carcinoma subjected to total laryngectomy. In the blood of patients we measured the concentration of t-PA:Ag, fibrinogen and FDP levels, PAI-1 activity, and ELT. The increase of t-PA and FDP concentrations, decrease of PAI-1 activity and fibrinogen level with simultaneous ELT shortening indicate on the fibrinolysis activation during the laryngectomy.
authors.affiliation: Katedry i Kliniki Otolaryngologii AM, Bydgoszczy.
authors.forename: S
authors.initials: S
authors.lastname: Betlejewski
authors.forename: D
authors.initials: D
authors.lastname: Burduk
authors.forename: A
authors.initials: A
authors.lastname: Białkowska
authors.forename: M
authors.initials: M
authors.lastname: Kotschy
mesh_terms: D000328:Adult; D000368:Aged; D005342:Fibrinolysis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D012712:Serum Globulins; D010959:Tissue Plasminogen Activator
vernacular_title: Wpływ laryngektomii na proces fibrynolizy we krwi chorych na raka krtani.