title: [Role of ecological factors in the pathogenesis of thyroid cancer in regions of Byelarus exposed during the Chernobyl AES accident].
abstract: The results of the increased functional asynchronism of the follicular structures of the thyroid gland in the endemic with respect to goitre regions at the intrathyroid distribution of radioactive iodine have been analysed. The unevenness of inclusion of radioiodine into the gland locus, which concentrate iodine, and the formation of higher dose effects in the microparts of the thyroid tissue altered by goitre, then the averaged values of irradiation of the whole gland inherent in the evaluation of risk of the thyroid carcinogenesis, has been shown. It is substantiated, that the increased deposit of some radionuclides and toxic microelements in the gland, altered by goitre, is the possible mechanism of promotion in the demonstration of the earlier initiated damaged genomes of follicular cells.
authors.affiliation: Institute for Radiation Ecology Problems, Belorussian Academy of Sciences, Minsk.
authors.forename: A F
authors.initials: AF
authors.lastname: Malenchenko
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D004463:Ecology; D006043:Goiter, Endemic / Q000150:complications*; D006801:Humans; D007455:Iodine / Q000172:deficiency / Q000378:metabolism; D007457:Iodine Radioisotopes / Q000378:metabolism; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D011210:Power Plants; D018788:Radioactive Hazard Release; D002094:Republic of Belarus; D012307:Risk Factors; D013961:Thyroid Gland / Q000737:chemistry / Q000473:pathology; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D014455:Ukraine; D014501:Uranium / Q000378:metabolism
chemical_list: D007457:Iodine Radioisotopes; D014501:Uranium; D007455:Iodine
vernacular_title: Rol' ékologicheskikh faktorov v patogeneze raka shchitovidnoĭ zhelezy v regionakh Belarusi, postradavshikh pri avarii na Chernobyl'skoĭ AES.