title: Proton-pump inhibitors for gastric acid-related disease.
abstract: Proton-pump inhibitors are the most effective drugs introduced to date for suppressing gastric acid production. Although they are used to treat the same conditions as histamine type-2 receptor antagonists, they differ from the latter drugs in how they inhibit acid production, and in how they should be given. Initial concerns over potential ill effects of hypergastrinemia due to long-term acid suppression with proton-pump inhibitors have been unfounded.
authors.affiliation: Cleveland Clinic Foundation, OH 44195, USA. frankot@cesmpt.ccf.org
authors.forename: T G
authors.initials: TG
authors.lastname: Franko
authors.forename: J E
authors.initials: JE
authors.lastname: Richter
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004941:Esophagitis / Q000188:drug therapy; D005744:Gastric Acid / Q000378:metabolism*; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D064747:Lansoprazole; D009853:Omeprazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy; D017494:Proton Pumps / Q000009:adverse effects*; D015043:Zollinger-Ellison Syndrome / Q000188:drug therapy
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D017494:Proton Pumps; D064747:Lansoprazole; D009853:Omeprazole