title: Polyamine profiles in the urine of patients with leukemia.
abstract: Eleven urinary polyamine levels were determined in controls (32 cases) and 43 patients with varying stages of leukemia including initial, relapse and complete remission, using gas chromatography nitrogen-phosphorus detection. Also, to indirectly evaluate the possible involvement of enzymes, precursor to product concentration ratios were compared between controls and patients with each stage of leukemia. As a result, it is confirmed that the ratio of N1-acSpd/N8-acSpd could be used as a diagnostic marker and the level of N1,N12-diacetylspermine could be used for determining disease stage and as a malignancy marker for leukemia. An altered metabolic pathway related to leukemia is also proposed in which N1,N12-diacetylspermine can be produced directly from spermine and N1,N12-diacetylspermine is a major source of N1-acetylspermidine.
authors.affiliation: Doping Control Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: J W
authors.initials: JW
authors.lastname: Suh
authors.forename: B C
authors.initials: BC
authors.lastname: Chung
authors.forename: S O
authors.initials: SO
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D015317:Biogenic Polyamines / Q000652:urine*; D014408:Biomarkers, Tumor / Q000652:urine; D005260:Female; D006801:Humans; D007938:Leukemia / Q000652:urine*; D008297:Male; D008875:Middle Aged
chemical_list: D015317:Biogenic Polyamines; D014408:Biomarkers, Tumor