Adhesion receptors and cytokine profiles in controlled tourniquet ischaemia in the upper extremity.
Adhesion mechanisms mediated by cytokines have been recognized to play a crucial role in ischaemia-reperfusion mechanisms. Although this phenomenon has been well investigated in organ transplantation, little data is available from upper extremity surgery. Profiles of adhesion molecules (CD11/CD18), key cytokines (TNF-alpha and IL-1), CD4+ and CD8+ lymphocytes, and polymorphonuclear neutrophils were investigated following controlled tourniquet ischaemia of the upper extremity for elective hand surgery. Data suggest that relatively short periods of ischaemia activate a mediator cascade and cell-cell interactions that may be associated with adverse pathopyhsiological effects on peripheral tissues after prolonged ischaemia.
Germann
G
G
Departments of Plastic, Hand and Burn Surgery, BG-Trauma Centre, Ludwigshafen, Germany.
Drücke
D
D
Steinau
H U
HU
D015703:Antigens, CD / Q000097:blood; D001132:Arm / Q000098:blood supply; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000276:immunology*; D007958:Leukocyte Count; D008875:Middle Aged; D009504:Neutrophils; D010865:Pilot Projects; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000097:blood; D015427:Reperfusion Injury / Q000276:immunology*; D014111:Tourniquets; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015703:Antigens, CD; D016207:Cytokines; D011971:Receptors, Immunologic; D014409:Tumor Necrosis Factor-alpha