Analysis of Bacillus subtilis tagAB and tagDEF expression during phosphate starvation identifies a repressor role for PhoP-P.
The tagAB and tagDEF operons, which are adjacent and divergently transcribed, encode genes responsible for cell wall teichoic acid synthesis in Bacillus subtilis. The Bacillus data presented here suggest that PhoP and PhoR are required for direct repression of transcription of the two operons under phosphate starvation conditions but have no regulatory role under phosphate-replete conditions. These data identify for the first time that PhoP-P has a negative role in Pho regulon gene regulation.
Liu
W
W
Laboratory for Molecular Biology, University of Illinois at Chicago, 60607, USA.
Eder
S
S
Hulett
F M
FM
D001412:Bacillus subtilis / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002473:Cell Wall / Q000378:metabolism; D003001:Cloning, Molecular; D003470:Culture Media; D004269:DNA, Bacterial; D015964:Gene Expression Regulation, Bacterial; D008074:Lipoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009876:Operon; D010544:Peroxidases; D010710:Phosphates / Q000378:metabolism* / Q000494:pharmacology; D011401:Promoter Regions, Genetic; D012697:Serine Endopeptidases / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D017855:Transferases (Other Substituted Phosphate Groups) / Q000235:genetics*
D001426:Bacterial Proteins; D002352:Carrier Proteins; D003470:Culture Media; D004269:DNA, Bacterial; D008074:Lipoproteins; D010710:Phosphates; C092406:TagA protein, bacteria; C089973:TagE protein, Vibrio cholerae; D014157:Transcription Factors; C061279:PhoR protein, Bacteria; C061064:PhoP protein, Bacteria; D010544:Peroxidases; C089974:TagD protein, Vibrio cholerae; D017855:Transferases (Other Substituted Phosphate Groups); C072175:CDP glycerol glycerophosphotransferase; D012697:Serine Endopeptidases