title: [Antithrombin III activity in health cats and its changes in selected disease].
abstract: Measurements of the antithrombin III (AT III) activity in feline plasma with a thrombin dependent chromogenic substrate assay using an automatic analyzer showed a high within run precision. The coefficient of variance was 1.82% (normal AT III activity) or 3.19% (decreased AT III activity), respectively. In comparison with the feline pool plasma the AT III activity in canine plasma was similar (93.7%) and in human reference plasma was lower (71.7%). Respecting healthy cats aged more than three months no distinct influence could be demonstrated on the AT III activity neither of age nor of gender (p = 0.2180). Based on the 2.5%- and 97.5%- quantile the reference range was 83.5-122.5% respecting the total number of healthy cats (n = 138) or 82.6-121.5% concerning the 116 European Shorthair cats. AT III activity of cats infected with feline immunodeficiency virus (n = 37) or teline leukemia virus (n = 20) as well as of cats suffering from different solitary tumors (n = 8) was not distinctly different from the control group (p > 0.05). On the contrary, a significant decrease of AT III activity was found in traumatized cats (n = 20; median = 80.8%, p < 0.0001) as well as in animals with chronic renal failure (n = 20; median = 91.7%, p = 0.0228) which can be mainly attributed to a consumption reaction or excessive renal loss, respectively.
authors.affiliation: Klinik für kleine Haustiere, Tierärztlichen Hochschule Hannover.
authors.forename: P A
authors.initials: PA
authors.lastname: Rivera Ramirez
authors.forename: A
authors.initials: A
authors.lastname: Deniz
authors.forename: W
authors.initials: W
authors.lastname: Wirth
authors.forename: R
authors.initials: R
authors.lastname: Mischke
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000032:analysis*; D001322:Autoanalysis; D002371:Cat Diseases / Q000097:blood*; D002415:Cats; D004285:Dogs; D016181:Feline Acquired Immunodeficiency Syndrome / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000662:veterinary; D016582:Leukemia, Feline / Q000097:blood; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results; D014947:Wounds and Injuries / Q000097:blood / Q000662:veterinary
chemical_list: D000990:Antithrombin III
vernacular_title: Antithrombin III-Aktivität bei der gesunden Katze und ihre Veränderung bei ausgewählten Erkrankungen.