title: Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas.
abstract: A single dose of 75 mg/kg 7,12 dimethylbenz[a]anthracene was administered to 50-day-old virgin female Sprague-Dawley rats and 100 days later, animals were randomized and provided with Teklad rodent chow mixed with a dose of 25 mg/rat/day ibuprofen for 35 days. Ibuprofen treatment reduced tumor volume (P < 0.05) and significantly inhibited gene expression of both cyclooxygenase- and cyclooxygenase-2 (P < 0.02). These results indicate that ibuprofen induced significant regression of established mammary carcinomas which was associated with inhibition of expression of isoforms of the gene responsible for prostaglandin production.
authors.affiliation: Department of Medical Microbiology and Immunology, Ohio State University, Columbus 43210, USA. robertson.48@osu.edu
authors.forename: F M
authors.initials: FM
authors.lastname: Robertson
authors.forename: M L
authors.initials: ML
authors.lastname: Parrett
authors.forename: F S
authors.initials: FS
authors.lastname: Joarder
authors.forename: M
authors.initials: M
authors.lastname: Ross
authors.forename: H M
authors.initials: HM
authors.lastname: Abou-Issa
authors.forename: G
authors.initials: G
authors.lastname: Alshafie
authors.forename: R E
authors.initials: RE
authors.lastname: Harris
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D007052:Ibuprofen / Q000494:pharmacology*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015127:9,10-Dimethyl-1,2-benzanthracene; D011451:Prostaglandin-Endoperoxide Synthases; D007052:Ibuprofen