title: Polyethylene glycol/microfibrillar collagen composite as a new resorbable hemostatic bone wax.
abstract: Although bone wax is effective at achieving hemostasis, it is nonresorbable, causes a foreign body reaction, and inhibits osteogenesis. We report development of a polyethylene glycol/microfibrillar collagen composite (PEG/MFC) that has inherent hemostatic qualities, is biodegradable, and is compatible with bone repair. PEG/MFC composite (n = 42) was placed in 5 mm cranial defects in New Zealand white rabbits. Hemostasis and healing were compared to unfilled defects (n = 32) and defects filled with standard bone wax (n = 10). Both PEG/MFC and bone wax handled well and stopped bleeding. The polyethylene glycol component was resorbed by 8 h, and the microfibrillar collagen was resorbed over 2 months, eliciting only a minor inflammatory response during the first month. Defects filled with the PEG/MFC composite showed similar amounts of bony regeneration as did unfilled control defects. At 4 weeks, healing bone accounted for 43 +/- 13% in those treated with PEG/MFC and 47 +/- 19% defect area in untreated holes. In contrast, less than 1% of the area was bone in defects filled with bone wax (p < 0.05). PEG/MFC composite provided excellent bony hemostasis and did not inhibit bone growth.
authors.affiliation: Division of Plastic Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Orgill
authors.forename: F W
authors.initials: FW
authors.lastname: Ehret
authors.forename: J F
authors.initials: JF
authors.lastname: Regan
authors.forename: J
authors.initials: J
authors.lastname: Glowacki
authors.forename: J B
authors.initials: JB
authors.lastname: Mulliken
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000032:analysis* / Q000378:metabolism; D001846:Bone Development / Q000502:physiology; D018786:Bone Substitutes / Q000009:adverse effects / Q000032:analysis* / Q000378:metabolism; D001842:Bone and Bones / Q000033:anatomy & histology / Q000502:physiology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003094:Collagen / Q000009:adverse effects / Q000737:chemistry*; D017102:Fracture Healing / Q000502:physiology; D006490:Hemostatics / Q000009:adverse effects / Q000032:analysis* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000737:chemistry*; D011817:Rabbits; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D006490:Hemostatics; D011092:Polyethylene Glycols; D003094:Collagen