title: Three new bistetrahydrofuran acetogenins from the seeds of Annona spinescens.
abstract: Three new bistetrahydrofuran acetogenins, carolins A-C (1-3), were isolated from the MeOH extract of Annona spinescens in addition to the known compound, squamocin (4). The structures of 1, 2, and 3 were elucidated by spectroscopic methods including LSIMS/MS technique and confirmed by a chemical transformation, The cytotoxic activity of the new compounds 1-3 is reported and discussed in comparison with 4 and the previously isolated spinencin (5).
authors.affiliation: Laboratoire de Pharmacognosie, U.R.A. 1843 CNRS (BIOCIS), Faculté de Pharmacie, Châtenay-Malabry, France.
authors.forename: E F
authors.initials: EF
authors.lastname: Queiroz
authors.forename: F
authors.initials: F
authors.lastname: Roblot
authors.forename: B
authors.initials: B
authors.lastname: Figadère
authors.forename: A
authors.initials: A
authors.lastname: Laurens
authors.forename: P
authors.initials: P
authors.lastname: Duret
authors.forename: R
authors.initials: R
authors.lastname: Hocquemiller
authors.forename: A
authors.initials: A
authors.lastname: Cavé
authors.forename: L
authors.initials: L
authors.lastname: Serani
authors.forename: O
authors.initials: O
authors.lastname: Laprévote
authors.forename: J
authors.initials: J
authors.lastname: Cotte-Laffitte
authors.forename: A M
authors.initials: AM
authors.lastname: Quéro
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured; D014709:Vero Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005233:Fatty Alcohols; C110790:carolin A; C110791:carolin B; C110792:carolin C; D015107:4-Butyrolactone