Tumor-specific apoptosis induced by the human monoclonal antibody SC-1: a new therapeutical approach for stomach cancer.
Stomach cancer is one of the most frequently occurring cancers worldwide, with a very poor prognosis, even after complete gastrectomy. We describe here an alternative therapeutical approach using a human monoclonal antibody (SC-1), which was isolated from a patient with diffuse-type gastric adenocarcinoma. We demonstrate that the antibody significantly reduces stomach cancer growth in vivo, by inducing tumor-specific apoptosis and that the antibody, even delivered in high doses, shows no toxic crossreactivity to other organs or tissues. The data presented here show that tumor-specific apoptosis can be induced and they give rise to the hope that human monoclonal antibodies with biological activity might present a completely new type of adjuvant cancer therapy.
Vollmers
H P
HP
Institut für Pathologie, Universität Würzburg, Germany.
Hensel
F
F
Hermann
R
R
Dämmrich
J
J
Wozniak
E
E
Gessner
P
P
Herrmann
B
B
Zimmermann
U
U
Müller-Hermelink
H K
HK
D000230:Adenocarcinoma / Q000276:immunology; D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D017209:Apoptosis; D001483:Base Sequence; D002455:Cell Division; D053938:DNA Fragmentation; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000737:chemistry; D007167:Immunotherapy; D008099:Liver / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D008969:Molecular Sequence Data; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007143:Immunoglobulin Heavy Chains; C111124:SC-1 monoclonal antibody