Parry-Romberg syndrome: follow-up imaging during suppressive therapy.
Parry-Romberg syndrome is a poorly--understood disorder characterized by progressive hemifacial atrophy involving the skin, soft tissue, and bone. Involvement of the central nervous system with impairment in neurologic function occurs infrequently. We describe a child with this syndrome in whom central nervous system involvement, documented on serial MRI, played a prominent role. We have attempted to correlate the clinical course with the radiologic findings, and to determine the impact of prednisone and methotrexate on the intracranial lesions.
Goldberg-Stern
H
H
Department of Neurology, Children's Hospital Medical Center, Cincinnati 45229-3039, USA.
deGrauw
T
T
Passo
M
M
Ball
W S
WS
D001921:Brain / Q000473:pathology*; D002648:Child; D005150:Facial Hemiatrophy / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000627:therapeutic use*; D011241:Prednisone / Q000627:therapeutic use*
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011241:Prednisone; D008727:Methotrexate