[Interaction of GABA-ergic component of NAD with benzodiazepine receptors during epileptogenesis].
Nitrozepam has been shown to decrease specific binding of [14C]NAD by the synaptic mem-branes approximately by 40%. Alongside with the latter GABA in the concentration of 10(-5) M potentiates the effect observed. Blocking in vitro of GABA receptors by bicuculin removes both the tranquilizer and GABA effect. While simulating epileptogenesis in animals the nitrazepam effect on [14C]NAD specific binding sites was somewhat more expressed in comparison with the norm. The interaction of NAD reception systems with benzodiazepine under the pathology is capable to be mediated not only by increasing GABA-ergic transfer, but it can occur place without GABA-ergic component of GABA-benzodiazepine receptor complex.
Fomenko
A I
AI
Donchenko
G V
GV
Khalmuradov
A A
AA
Stepanenko
S P
SP
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001640:Bicuculline; D001667:Binding, Competitive / Q000187:drug effects; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism; D018756:GABA Antagonists; D018757:GABA Modulators / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009243:NAD / Q000378:metabolism* / Q000494:pharmacology; D009536:Niacinamide / Q000494:pharmacology; D009567:Nitrazepam / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D013570:Synaptic Membranes; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D018756:GABA Antagonists; D018757:GABA Modulators; D011963:Receptors, GABA-A; D009243:NAD; D009536:Niacinamide; D005680:gamma-Aminobutyric Acid; D009567:Nitrazepam; D001640:Bicuculline
Uchastie GAMK-eergicheskogo komponenta vo vzaimodełstvii NAD s benzodiazepinovymi retseptorami pri 'epileptogeneze