Immune-cell system provides the development of extraneural tumors in the ethyl-nitrosourea model of neurocarcinogenesis.
Immunological suppression of the immune-cell system by means of cyclosporin-A was performed at a stage corresponding to microtumor development in the ethyl-nitrosourea (ENU) model of neurocarcinogenesis. The results that we have obtained suggest that this immunological manipulation is related to the appearance of extraneural undifferentiated tumors, suggesting that the immune-cell system is effective in immunocompetent rodents for providing extraneural ENU carcinogenesis.
Vaquero
J
J
Neurosciences Research Unit of the Mapfre-Medicine Foundation, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Zurita
M
M
Oya
S
S
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced*; D016572:Cyclosporine / Q000494:pharmacology*; D005038:Ethylnitrosourea; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental; D009442:Neurilemmoma / Q000139:chemically induced*; D009837:Oligodendroglioma / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D005038:Ethylnitrosourea