17-alpha-Hydroxyprogesterone caproate and natural progesterone in assisted reproduction: a comparative study.
The use of luteal phase support has been demonstrated in patients undergoing an IVF/ET procedure. This study was designed to compare the absorption and the efficacy of two different luteal supports: 17-alpha-hydroxyprogesterone caproate (Lentogest, AMSA, Italy) and natural Progesterone (Prontogest, AMSA, Italy). A total of 80 patients received luteal supplementation with 50 mg of natural P/day intramuscularly, until beta-hCG evaluation. Then, in case of positive beta-hCG, patients were randomly divided into two groups (A and B) in order to compare two different protocols: Group A, 17-OHPc (341 mg once a week) and Group B, natural P (50 mg/day) both intramuscularly and extended for 10-12 weeks. Our study showed that the treatment with 17-OHPc results in a higher percentage of pregnancy rate compared to natural P, but the differences are not statistically significant. Thus, we emphasize that 17-OHPc preparation for better acceptance appears to be the most suitable and comfortable method for luteal phase support.
Abate
A
A
Papardo Hospital, Messina.
Brigandì
A
A
Costabile
L
L
Abate
F G
FG
Balzano
E
E
Perino
M
M
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D006908:Hydroxyprogesterones / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D045167:Progesterone Congeners / Q000493:pharmacokinetics / Q000627:therapeutic use*
D006908:Hydroxyprogesterones; D045167:Progesterone Congeners; D000077713:17 alpha-Hydroxyprogesterone Caproate; D011374:Progesterone