Effects of amphetamine on the development of Moloney sarcoma virus-induced tumors in mice.
Experiments were conducted to evaluate the effects of amphetamine (0. 4 mg/kg) on the development of autochthonous tumors induced by the Moloney sarcoma virus (MSV) in Balb/c female mice. Enhancement of MSV-induced tumor incidence and tumor growth was observed, together with a delay in the usual prompt regression of the tumors, when mice were daily injected with amphetamine for 3 days after MSV-inoculation. However, no effects of amphetamine on tumor development were observed when it was administered during the 3 days before tumor inoculation.
Freire-Garabal
M
M
Department of Pharmacology, School of Pharmacy, University of Santiago de Compostela, Campus Sur, Santiago de Compostela, 15706, Spain.
Nuñez-Iglesias
M J
MJ
Rey-Méndez
M
M
Pereiro-Raposo
M D
MD
Riveiro
P
P
Fernández-Rial
J C
JC
Losada
C
C
Gandoy
M
M
Mayán
J M
JM
D018663:Adrenergic Agents / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007279:Injections, Subcutaneous; D051379:Mice; D008807:Mice, Inbred BALB C; D008980:Moloney murine sarcoma virus; D011292:Premedication; D012192:Retroviridae Infections / Q000188:drug therapy / Q000473:pathology*; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000473:pathology*; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000473:pathology*
D018663:Adrenergic Agents; D000661:Amphetamine