Polymer blend implant for ocular delivery of fluorometholone.
Ocular implants containing fluorometholone (FLM) were prepared using blends of poly (DL-lactic acid) (PLA) and polyvinyl pyrrolidone (PVP). The effect of the fraction of PVP content on the release of FLM from the implant was investigated in vitro. The drug was released from the device by approximately following first order kinetics within the period of 40 d. The release rate gradually increased with an increase in the PVP content. The in vivo study after implantation in the anterior chamber of rabbit eyes indicated that the PLA-PVP implant showed a good correlation between the in vitro and in vivo release of FLM. The present polymer blend implant demonstrated a constant level of FLM in the aqueous humor for one month.
Morita
Y
Y
Kobe Creative Center, Senju Pharmaceutical Co., Ltd., Japan.
Saino
H
H
Tojo
K
K
D000818:Animals; D000867:Anterior Chamber; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001082:Aqueous Humor / Q000378:metabolism; D001672:Biocompatible Materials / Q000009:adverse effects; D016503:Drug Delivery Systems; D004343:Drug Implants / Q000009:adverse effects; D005123:Eye / Q000737:chemistry / Q000378:metabolism; D005469:Fluorometholone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019344:Lactic Acid; D008297:Male; D008854:Microscopy, Electron; D011091:Polyesters; D011108:Polymers; D011205:Povidone; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; D004343:Drug Implants; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D011205:Povidone; D005469:Fluorometholone