title: Low levels of linoleic acid in plasma total lipids of HIV-1 seropositive children.
abstract: OBJECTIVE
  To assess the plasma fatty acid status of a group of well-nourished children with the human immunodeficiency virus type-1 (HIV-1) and how this relates to the blood total CD4+ lymphocyte count.
  
  
  METHODS
  Fourteen HIV-1 seropositive children at various stages of disease and with adequate growth indices were assessed and compared to a control group of 30 healthy children.
  
  
  RESULTS
  The concentrations (mg/dL) of plasma total fatty acids were not different between the two groups. HIV-1 seropositive children presented lower levels of 18-C essential polyunsaturated fatty acids (PUFA: linoleic acid, LA, and alpha-linolenic acid) and higher levels of their 20-C long-chain derivatives (di-homo-gamma-linolenic acid, arachidonic acid, AA, and eicosapentaenoic acid) and docosahexaenoic acid in their plasma total lipids. The lowest plasma LA levels were observed in the subgroup of patients with more advanced stages of disease. In bivariate analyses the plasma LA levels related positively (Spearman r = 0.50, p = 0.06), while the LA/AA ratio related negatively (Spearman r = -0.51, p = 0.06), to the total CD4+ count.
  
  
  CONCLUSIONS
  Childhood HIV-1 infection is associated with changes in plasma fatty acid profile suggestive of an increased PUFA turnover. Decreased levels of LA (together with higher plasma AA levels) appear to be associated with more advanced clinical and biochemical stages of disease.
authors.affiliation: Department of Pediatrics, University of Milan Medical School, San Paolo Hospital, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Agostoni
authors.forename: G V
authors.initials: GV
authors.lastname: Zuccotti
authors.forename: E
authors.initials: E
authors.lastname: Riva
authors.forename: S
authors.initials: S
authors.lastname: Decarlis
authors.forename: L
authors.initials: L
authors.lastname: Bernardo
authors.forename: M G
authors.initials: MG
authors.lastname: Bruzzese
authors.forename: M
authors.initials: M
authors.lastname: Giovannini
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid; D000886:Anthropometry; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D004281:Docosahexaenoic Acids / Q000097:blood; D002149:Energy Intake; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006679:HIV Seropositivity / Q000097:blood*; D006801:Humans; D007223:Infant; D019787:Linoleic Acid / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D018977:Micronutrients
chemical_list: D004041:Dietary Fats; D004044:Dietary Proteins; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D018977:Micronutrients; D004281:Docosahexaenoic Acids; D019787:Linoleic Acid; D015126:8,11,14-Eicosatrienoic Acid