[Acute myeloid leukemia MO: clinical and laboratory characteristics].
BACKGROUND
A recent update of FAB classification has included a myeloid leukemia subtype with a minimal degree of differentiation, that has been denominated LMA-MO.


OBJECTIVE
To report the clinical, morphological and immunophenotypic features of patients with LMA-MO.


METHODS
Eight patients, out of 368, with acute myeloid leukemia that were studied in the Hematology Laboratory of a public hospital in Santiago, were classified as LMA-MO.


RESULTS
Blast cell morphology was undifferentiated or of subtype FAB-L2 lymphoblastic leukemia with medium sized blasts, agranular basophilic cytoplasm, reticular nuclear chromatin and a prominent nucleolus. Cytochemical staining was negative for peroxidase and esterases, immunophenotyping showed the expression of one or more myeloid antigens (CD13, CD33) and was negative for lymphoid antigens. Immunocytochemical expression of myeloperoxidase was positive in the three cases where it was performed. Only one patient achieved complete remission and is free of disease after 36 months of follow up. All other patients died without obtaining remission, six shortly after the onset and one 12 months after.


CONCLUSIONS
The diagnosis of LMA-MO is essential considering its dismal prognosis.
Cabrera
E
E
Sección Hematología, Facultad de Medicina, Universidad de Chile (Campus Oriente), Hospital del Salvador, Chile.
Rojas
B
B
Labra
S
S
Matutes
E
E
Puga
B
B
D000208:Acute Disease; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007231:Infant, Newborn; D007951:Leukemia, Myeloid / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged
Leucemia mieloide aguda Mo: características clínicas y de laboratorio.