title: Detection of human herpesvirus-8 DNA in oral ulcer tissues of HIV-infected individuals.
abstract: OBJECTIVE
  To determine the frequency of detection of human herpesvirus-8 (HHV-8) in HIV-related oral ulcers.
  
  
  METHODS
  Analysis of archived biopsy material.
  
  
  METHODS
  Nested polymerase chain reaction of DNA extracts.
  
  
  RESULTS
  HHV-8 DNA was detected in six of 10 oral ulcers of HIV-positive patients without oral Kaposi's sarcoma (KS) lesions and five of 11 oral KS lesions. The positive non-KS samples were derived from various oral sites.
  
  
  CONCLUSIONS
  In HIV-positive people, HHV-8 can infect oral tissues that are not affected by KS.
authors.affiliation: Department of Oral Medicine, Eastman Dental Institute, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Di Alberti
authors.forename: S R
authors.initials: SR
authors.lastname: Porter
authors.forename: P M
authors.initials: PM
authors.lastname: Speight
authors.forename: C M
authors.initials: CM
authors.lastname: Scully
authors.forename: J M
authors.initials: JM
authors.lastname: Zakrzewska
authors.forename: I G
authors.initials: IG
authors.lastname: Williams
authors.forename: L
authors.initials: L
authors.lastname: Artese
authors.forename: A
authors.initials: A
authors.lastname: Piattelli
authors.forename: S L
authors.initials: SL
authors.lastname: Ngui
authors.forename: C G
authors.initials: CG
authors.lastname: Teo
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis*; D015658:HIV Infections / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D009061:Mouth Mucosa / Q000821:virology; D019226:Oral Ulcer / Q000821:virology*; D012514:Sarcoma, Kaposi / Q000821:virology
chemical_list: D004279:DNA, Viral