title: Association between hyperhomocysteinemia and ischemic heart disease in Sri Lankans.
abstract: OBJECTIVE
  The objective of this study was to examine the relation between hyperhomocysteinaemia and ischemic heart disease in a cohort of Sri Lankan patients with ischemic heart disease.
  
  
  METHODS
  Serum homocysteine, cysteine and cysteinylglyceine were measured in 54 patients with a definite diagnosis of ischemic heart disease and compared with those of an age and sex matched control group.
  
  
  RESULTS
  Patients with coronary ischaemia had significantly higher mean concentrations of homocysteine and its metabolite cysteine (P<0.01). Of the 54 patients with ischemic heart disease 14 (35%) had fasting homocysteine concentrations above the 90th percentile of the controls (odds ratio 3.2, 95% CL 1.0-11.3).
  
  
  CONCLUSIONS
  Hyperhomocysteinaemia is associated with a three fold increase in coronary risk.
authors.affiliation: Department of Medicine, Faculty of Medicine, Peradeniya, Sri Lanka.
authors.forename: S
authors.initials: S
authors.lastname: Mendis
authors.forename: S B
authors.initials: SB
authors.lastname: Athauda
authors.forename: K
authors.initials: K
authors.lastname: Takashi
mesh_terms: D000328:Adult; D000368:Aged; D015984:Causality; D015331:Cohort Studies; D003545:Cysteine / Q000097:blood; D004151:Dipeptides / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology*; D016017:Odds Ratio; D012016:Reference Values; D012307:Risk Factors; D013188:Sri Lanka / Q000453:epidemiology
chemical_list: D004151:Dipeptides; D006710:Homocysteine; C028505:cysteinylglycine; D003545:Cysteine