[Activity of the enzymes of ethanol and acetaldehyde metabolism in rats with varying initial sensitivity to alcohol].
The experiments were carried out on male rats with different sensitivity to alcohol. To assess sensitivity to ethanol effects, we have used ethanol-induced sleep time and variations in rectal temperature of alcohol-intoxicated animals. Activity of alcohol dehydrogenase, microsomal ethanol-oxidizing system, catalase and aldehyde dehydrogenase in the liver as well as ethanol and acetaldehyde levels in the blood were determined after alcohol intoxication (3.5 g/kg, i.p., 8 days). The development of alcohol tolerance was accompanied by induction of the microsomal ethanol-oxidizing system in long-sleeping rats and in short-sleeping rats as well as by an increase in ethanol and acetaldehyde levels in the blood.
Bardina
L R
LR
Satanovskaia
V I
VI
Pron'ko
P S
PS
Kuz'mich
A B
AB
D000079:Acetaldehyde / Q000378:metabolism*; D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000818:Animals; D002374:Catalase / Q000378:metabolism*; D004361:Drug Tolerance; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats
D000431:Ethanol; D000426:Alcohol Dehydrogenase; D002374:Catalase; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde
Aktivnost' fermentov metabolizma étanola i atsetal'degida u krys s razlichnoĭ iznachal'noĭ chuvstvitel'nost'iu k alkogoliu.