Synthesis and biological evaluation of flavanones and flavones related to podophyllotoxin.
A series of novel flavonoids comprising structural elements present in the antineoplastic agents podophyllotoxin and etoposide was synthesized. These oxygen-containing analogues of antiproliferative quinolones moderate cytotoxicity towards L1210 and HT-29 cell lines.
Gonzalez De Peredo
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Unité Mixte de Recherche Institut Curie-CNRS, Institut Curie, Section de Recherche, Paris, France.
Léonce
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Monneret
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C
Dauzonne
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D
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D005047:Etoposide / Q000737:chemistry; D044950:Flavanones; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007641:Keratolytic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D011034:Podophyllotoxin / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D044950:Flavanones; D005419:Flavonoids; D007641:Keratolytic Agents; D005047:Etoposide; D004317:Doxorubicin; D011034:Podophyllotoxin; C028610:flavanone