title: Effect of hypoxia on pulmonary blood flow-segmental vascular resistance relationship in perfused cat lungs.
abstract: To investigate the effect of alveolar hypoxia on the pulmonary blood flow-segmental vascular resistance relationship, we determined the longitudinal distribution of vascular resistance while increasing blood flow during hyperoxia or hypoxia in perfused cat lungs. We measured microvascular pressures by the micropipette servo-null method, partitioned the pulmonary vessels into three segments [i.e., arterial (from main pulmonary artery to 30- to 50-micron arterioles), venous (from 30- to 50-micron venules to left atrium), and microvascular (between arterioles and venules) segments] and calculated segmental vascular resistance. During hyperoxia, total resistance decreased with increased blood flow because of a reduction of microvascular resistance. In contrast, during hypoxia, not only microvascular resistance but also arterial resistance decreased with increase of blood flow while venous resistance remained unchanged. The reduction of arterial resistance was presumably caused by arterial distension induced by an elevated arterial pressure during hypoxia. We conclude that, during hypoxia, both microvessels and arteries >50 micron in diameter play a role in preventing further increases in total pulmonary vascular resistance with increased blood flow.
authors.affiliation: Division of Respiratory Diseases, Department of Internal Medicine, Kanazawa Medical University, Uchinada, Ishikawa 920-0265, Japan. toga-h@kanazawa-med.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Toga
authors.forename: H
authors.initials: H
authors.lastname: Okazaki
authors.forename: M
authors.initials: M
authors.lastname: Ishigaki
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.forename: T
authors.initials: T
authors.lastname: Fukunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Nagasaka
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Ohya
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D005260:Female; D018496:Hyperoxia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008168:Lung / Q000502:physiology*; D008297:Male; D008833:Microcirculation / Q000502:physiology; D011650:Pulmonary Alveoli / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology*; D018924:Vascular Capacitance / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology