title: Natural history of stenosis from intracranial atherosclerosis by serial angiography.
abstract: OBJECTIVE
  Knowledge of the natural history of stenoses due to intracranial atherosclerosis may be useful for evaluating possible treatments such as angioplasty.
  
  
  METHODS
  We retrospectively reviewed records over a 7-year period to identify patients with intracranial atherosclerotic stenoses and serial angiograms. Quantitative measurements of stenoses were made in a blinded manner, and clinical outcomes were reviewed.
  
  
  RESULTS
  We identified 21 patients with 45 intracranial stenoses who underwent repeat angiography at an average interval of 26.7 months. The average stenosis for all intracranial lesions was 43.9% initially and 51.8% on follow-up (P=.032). The average stenosis in the intracranial internal carotid artery (ICA) was stable (51.2% versus 52.6%). The average stenosis in the anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA) progressed from 32.4% to 49.7% (P=.037). Based on a minimum 10% change, 20% of intracranial ICA lesions progressed compared with 61% of ACA, MCA, and PCA lesions. Regression occurred in 14% of the intracranial ICA group and 28% of the ACA-MCA-PCA group. Cerebrovascular events were infrequent during this period, with 4 transient ischemic attacks and 1 intracerebral hemorrhage.
  
  
  CONCLUSIONS
  Intracranial atherosclerotic stenoses are dynamic lesions demonstrating both progression and regression.
authors.affiliation: Department of Neurology, Washington University School of Medicine, St Louis, Mo, USA. akins@cwnet.com
authors.forename: P T
authors.initials: PT
authors.lastname: Akins
authors.forename: T K
authors.initials: TK
authors.lastname: Pilgram
authors.forename: D T
authors.initials: DT
authors.lastname: Cross
authors.forename: C J
authors.initials: CJ
authors.lastname: Moran
mesh_terms: D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002533:Cerebral Angiography; D002539:Cerebral Arterial Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies