title: Fibroblast growth factor 2 control of vascular tone.
abstract: Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion, inflammation, vessel injury/repair, wound healing, temperature regulation, digestion, exercise physiology, and metabolism. Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes, including growth of the tissue layers of vessel walls, functions in vascular tone control. Fgf2 knockout mice are morphologically normal and display decreased vascular smooth muscle contractility, low blood pressure and thrombocytosis. Following intra-arterial mechanical injury, FGF2-deficient vessels undergo a normal hyperplastic response. These results force us to reconsider the function of FGF2 in vascular development and homeostasis in terms of vascular tone control.
authors.affiliation: Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267, USA.
authors.forename: M
authors.initials: M
authors.lastname: Zhou
authors.forename: R L
authors.initials: RL
authors.lastname: Sutliff
authors.forename: R J
authors.initials: RJ
authors.lastname: Paul
authors.forename: J N
authors.initials: JN
authors.lastname: Lorenz
authors.forename: J B
authors.initials: JB
authors.lastname: Hoying
authors.forename: C C
authors.initials: CC
authors.lastname: Haudenschild
authors.forename: M
authors.initials: M
authors.lastname: Yin
authors.forename: J D
authors.initials: JD
authors.lastname: Coffin
authors.forename: L
authors.initials: L
authors.lastname: Kong
authors.forename: E G
authors.initials: EG
authors.lastname: Kranias
authors.forename: W
authors.initials: W
authors.lastname: Luo
authors.forename: G P
authors.initials: GP
authors.lastname: Boivin
authors.forename: J J
authors.initials: JJ
authors.lastname: Duffy
authors.forename: S A
authors.initials: SA
authors.lastname: Pawlowski
authors.forename: T
authors.initials: T
authors.lastname: Doetschman
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001808:Blood Vessels / Q000502:physiology*; D020212:Carotid Artery Injuries; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000502:physiology*; D006321:Heart / Q000254:growth & development; D006339:Heart Rate; D006410:Hematopoiesis / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D011995:Recombination, Genetic; D014661:Vasoconstriction
chemical_list: D016222:Fibroblast Growth Factor 2