title: Spinal cord complications of thoracoabdominal aneurysm surgery.
abstract: BACKGROUND
  Although rare, paralysis secondary to spinal cord ischaemia after aortic aneurysm surgery is a devastating complication. Many papers have been published on this topic but without a clear consensus on the best way of minimizing the problem. Recent articles have included advanced pharmacological approaches and the literature has been reviewed in light of these.
  
  
  METHODS
  Relevant papers were identified by an extensive text word search of the Medline database and a review of quoted articles.
  
  
  RESULTS
  Spinal cord complications are commoner after the repair of Crawford type II aneurysms than less extensive aneurysms. The presence of dissection, rupture and prolonged clamp times are associated with an increased incidence. About a quarter of all cord problems develop over 24 h after surgery and this may be due to a reperfusion type injury, although the exact mechanisms are by no means clear.
  
  
  CONCLUSIONS
  A combination of rapid surgery, left heart bypass for the repair of more extensive aneurysms, free spinal drainage and the avoidance of postoperative hypoxia and hypotension help to minimize spinal cord ischaemia. No pharmacological agent has yet been shown conclusively to improve outcome in the clinical setting.
authors.affiliation: Academic Surgical Unit, Imperial College School of Medicine at St Mary's, St Mary's Hospital, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Lintott
authors.forename: H M
authors.initials: HM
authors.lastname: Hafez
authors.forename: G
authors.initials: G
authors.lastname: Stansby
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D004195:Disease Models, Animal; D006801:Humans; D007036:Hypothermia, Induced; D007430:Intraoperative Care; D007511:Ischemia / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology*; D013116:Spinal Cord / Q000098:blood supply; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000517:prevention & control