[The proliferation, differentiation and death of cardiomyocytes during exposure to an antioxidant].
Influence of ionolum--vitamin E analog on differentiation, proliferative activity, cell death and content of products of lipid peroxide oxidation in chick embryo cardiac muscular tissue was studied in normal embryogenesis and in myocardial hypertrophy development. Administration of antioxidant to chick embryo was shown to result in intensified and prolonged proliferation, delayed differentiation and reduced cardiomyocyte death index both in normal histogenesis and in myocardial hypertrophy development. Use of the drug leads to viability increase in embryos exposed to extreme environmental factor action.
Ibragimova
I F
IF
Danilov
R K
RK
Zagidullin
Sh Z
ShZ
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D002645:Chickens; D006321:Heart / Q000187:drug effects* / Q000196:embryology; D015227:Lipid Peroxidation / Q000187:drug effects; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D002084:Butylated Hydroxytoluene
Proliferatsiia, differentsiatsiia i gibel' kardiomiotsitov pri vozdeĭstvii antioksidanta.