The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.
The relationship between two methods of assessing tumour oxygenation in vivo, namely oxygen electrode measurement and magnetic resonance spectroscopy (MRS) of the fluorinated 2-nitroimidazole SR-4554, was investigated. Using three tumour models (two sites), no linear correlation was observed between 19F retention index and pO2 parameters (r < or = 0.3). Substantial retention of SR-4554 (19F retention index > 0.5) was, however, associated with low tumour pO2 (% pO2 < or = 5 mmHg = 60%). Depending on the pO2 parameters used, SR-4554 administration was shown to produce either a significant or a non-significant increase in tumour oxygenation. We conclude that measurement of SR-4554-related compound(s) by 19F-MRS has the potential to detect clinically relevant levels of tumour hypoxia.
Aboagye
E O
EO
CRC Department of Medical Oncology, Beatson Laboratories, Glasgow, UK.
Maxwell
R J
RJ
Horsman
M R
MR
Lewis
A D
AD
Workman
P
P
Tracy
M
M
Griffiths
J R
JR
D000818:Animals; D002277:Carcinoma / Q000378:metabolism; D015687:Cell Hypoxia; D005462:Fluorine Radioisotopes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D015335:Molecular Probes / Q000737:chemistry; D009593:Nitroimidazoles / Q000737:chemistry; D010100:Oxygen / Q000378:metabolism*
D005462:Fluorine Radioisotopes; D015335:Molecular Probes; D009593:Nitroimidazoles; C095171:SR 4554; D010100:Oxygen