Atypical adenomatous hyperplasia of the prostate: a premalignant lesion?
To better understand genetic alterations in atypical adenomatous hyperplasia (AAH) of the prostate, we examined the prevalence of allelic imbalance at 5 microsatellite polymorphic markers on chromosomes 7q31-35, 8p12-21, 8p22, 8q22.2, and 18q12.2 from 15 patients with AAH. DNA samples were obtained from formalin-fixed paraffin-embedded sections using tissue microdissection. We found allelic imbalance in 7 of 15 (47%) cases of AAH. Genetic changes that commonly occur in early prostatic carcinogenesis and prostate carcinoma are found in AAH. Current data provide evidence of a genetic link between some cases of AAH and carcinoma.
Cheng
L
L
Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Shan
A
A
Cheville
J C
JC
Qian
J
J
Bostwick
D G
DG
D000230:Adenocarcinoma / Q000235:genetics; D000483:Alleles; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000235:genetics / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000145:classification / Q000235:genetics / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000235:genetics