The effect of GABAergic system activity on hyperthermia-induced seizures in rats.
Developing rats were given GABA antagonists and agonist before electrical seizure discharges were induced by heating the brain of a rat with infra-red rays. The thresholds for the GABA antagonist groups were significantly lower than that for the control, and the threshold for the GABA agonist group was significantly higher than that for the control. These results support the hypothesis that reduced GABAergic system activity underlies febrile seizures.
Fukuda
M
M
Department of Pediatrics, Ehime University School of Medicine, Japan.
Morimoto
T
T
Nagao
H
H
Kida
K
K
D000704:Analysis of Variance; D000818:Animals; D001640:Bicuculline / Q000627:therapeutic use; D001833:Body Temperature Regulation / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D018755:GABA Agonists / Q000627:therapeutic use; D018756:GABA Antagonists / Q000627:therapeutic use; D006358:Hot Temperature; D008297:Male; D009118:Muscimol / Q000627:therapeutic use; D051381:Rats; D011917:Rats, Inbred Lew; D012640:Seizures / Q000209:etiology / Q000503:physiopathology*; D012663:Semicarbazides / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D018755:GABA Agonists; D018756:GABA Antagonists; D012663:Semicarbazides; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; C005151:thiosemicarbazide; D001640:Bicuculline