title: Stereoselection in designed three-helix bundle metalloproteins.
abstract: The stereochemical consequences of the metal-ion assisted self-assembly of parallel three-helix peptide bundles are investigated. Chiral induction in the self-assembly of systems containing extensive protein secondary structure is compared with the racemic synthesis of short metallopeptides. Isolation and characterization of the individual stereoisomers of an exchange-inert metalloprotein provide structural insights into analogous exchange-labile systems.
authors.affiliation: Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Case
authors.forename: M R
authors.initials: MR
authors.lastname: Ghadiri
authors.forename: M W
authors.initials: MW
authors.lastname: Mutz
authors.forename: G L
authors.initials: GL
authors.lastname: McLendon
mesh_terms: D002942:Circular Dichroism; D019277:Entropy; D007501:Iron / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008667:Metalloproteins / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011487:Protein Conformation; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D008667:Metalloproteins; D010455:Peptides; D012428:Ruthenium; D007501:Iron