HBED: A potential alternative to deferoxamine for iron-chelating therapy.
To examine the potential clinical usefulness of the hexadentate phenolic aminocarboxylate iron chelator N, N-bis(2-hydroxybenzyl)ethylenediamine-N,N-diacetic acid (HBED) for the chronic treatment of transfusional iron overload, we compared the iron excretion induced by subcutaneous (SC) injection of HBED and deferoxamine (DFO), the reference chelator, in rodents and primates. In the non-iron-overloaded, bile-duct-cannulated rat, a single SC injection of HBED, 150 micromol/kg, resulted in a net iron excretion that was more than threefold greater than that after the same dose of DFO. In the iron-loaded Cebus apella monkey, a single SC injection of HBED, 150 micromol/kg, produced a net iron excretion that was more than twice that observed after the same dose of SC DFO. In patients with transfusional iron overload, SC injections of HBED may provide a much needed alternative to the use of prolonged parenteral infusions of DFO.
Bergeron
R J
RJ
Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, USA.
Wiegand
J
J
Brittenham
G M
GM
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use*; D003676:Deferoxamine / Q000627:therapeutic use*; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000882:Haplorhini; D019190:Iron Overload / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D065227:Transfusion Reaction
D000931:Antidotes; D002614:Chelating Agents; C037740:N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid; D004492:Edetic Acid; D003676:Deferoxamine