Reduced red-cell folate in mania.
Forty-five hospitalised patients with DSM-III-R diagnosis of mania, were found to have a mean red-cell folate level of 193 nmol/l, as compared to 896 nmol/l in the control group (P < 0.00001). Assessment of serum folate in both groups showed no significant differences in the levels. Furthermore the manic patients and the controls were matched by the socio-economic status. This indicated that the reduced red-cell folate in mania is associated with the illness and not due to reduced absorption or dietary deficiency of folate. Considering previous studies that showed reduced red-cell folate in depression, our findings suggest that reduced red-cell folate occurred in both phases of bipolar disorders.
Hasanah
C I
CI
School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. hasanah@kb.usm.my
Khan
U A
UA
Musalmah
M
M
Razali
S M
SM
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D005492:Folic Acid / Q000032:analysis / Q000097:blood*; D005494:Folic Acid Deficiency / Q000097:blood* / Q000175:diagnosis; D006760:Hospitalization; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012959:Socioeconomic Factors
D005492:Folic Acid