title: Analytical goals in therapeutic drug monitoring.
abstract: The practice of therapeutic drug monitoring is based on several disciplines, including pharmacokinetics, pharmacodynamics, and chemical analysis. The impact of the analysis on the determination of pharmacokinetic parameters is not well appreciated. Analytical goals in therapeutic drug monitoring should be established by determining the nature of the problem to be solved, selecting the appropriate matrix and methodology to solve the problem, and developing valid analytical schemes that are performed competently with appropriate quality and interpreted within the framework of the problem.
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University Medical Center, Indianapolis, IN 46202-5120, USA. lbowers@iupui.edu
authors.forename: L D
authors.initials: LD
authors.lastname: Bowers
mesh_terms: D001774:Blood Chemical Analysis; D002851:Chromatography, High Pressure Liquid; D016903:Drug Monitoring; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis*; D010599:Pharmacokinetics; D012680:Sensitivity and Specificity
chemical_list: D004364:Pharmaceutical Preparations