title: Metachronous neurohypophyseal germinoma occurring 8 years after total resection of pineal mature teratoma.
abstract: BACKGROUND
  Metachronous germ cell tumor in the central nervous system is extremely rare. To our knowledge, only one patient presenting conceivable metachronous intracranial germ cell tumor has been reported.
  
  
  METHODS
  A neurohypophyseal germinoma occurring 8 years after total resection of a pineal mature teratoma is presented. The patient underwent total resection of a large pineal mass in 1987. Histologic investigation revealed a mature teratoma without any immature or germinomatous components. In 1995, he developed diabetes insipidus. Magnetic resonance imaging depicted an intrasellar mass extending to the floor of the third ventricle. A transsphenoidal biopsy revealed histologically pure germinoma.
  
  
  CONCLUSIONS
  The second neurohypophyseal germinoma was considered to be a de novo metachronous neoplasm rather than a recurrence of the original mature teratoma.
authors.affiliation: Department of Neurosurgery, University of Hokkaido School of Medicine, Sapporo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Sawamura
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Abe
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000601:surgery*; D002648:Child; D018237:Germinoma; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary; D010870:Pineal Gland / Q000601:surgery*; D010904:Pituitary Gland, Posterior; D010911:Pituitary Neoplasms; D013724:Teratoma / Q000601:surgery*