The real life of voltage-gated K+ channels: more than model behaviour.
The past ten years have provided an embarrassment of riches for those interested in cloned voltage-gated K+ (Kv) channels. Details of their physiology and pharmacology in expression systems, and their precise cellular location abound, making them excellent targets for pharmacologists. However, there is still a considerable and important gap in our knowledge between the behaviour of expressed Kv channels and K+ currents in vivo. In this review Brian Robertson focuses on a few of the recent developments in the field of Kv channels, namely modulation of their behaviour by accessory subunits, their control, and localization of identified Kv subunits.
Robertson
B
B
Department of Biochemistry, Imperial College, London, UK.
D000818:Animals; D001921:Brain / Q000378:metabolism; D003001:Cloning, Molecular; D004594:Electrophysiology; D005786:Gene Expression Regulation / Q000235:genetics; D051663:Kv1.2 Potassium Channel; D009154:Mutation / Q000235:genetics; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D009865:Oocytes / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology*; D015221:Potassium Channels / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D024642:Potassium Channels, Voltage-Gated; D011689:Purkinje Cells / Q000378:metabolism; D015222:Sodium Channels / Q000187:drug effects; D013111:Spider Venoms / Q000494:pharmacology
C097576:DTX9.2 protein, Diguetia canities; D051663:Kv1.2 Potassium Channel; D018377:Neurotransmitter Agents; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated; D015222:Sodium Channels; D013111:Spider Venoms; D011188:Potassium