title: Self-reported medication non-compliance in the elderly.
abstract: OBJECTIVE
  To assess self-reported compliance with prescribed medications in a population of elderly patients prior to their hospital admission in an attempt to understand further the factors which influence drug-taking patterns.
  
  
  METHODS
  Information which, based on personal clinical experience and published research, may impact on compliance was collected for patients by way of a chart review within 3 days of hospital admission, a search of patient computerised hospital records and an interview. All crude data were coded and entered into a computerised relational database. Each patient's data were assessed using the Naranjo algorithm and the score was recorded. Chi-square analysis highlighted those factors which significantly influenced compliance, sub-divided into under-compliance (taking less medicine than prescribed) and over-compliance (taking more medicine than prescribed). Inter-relationships between variables were investigated using multiple-regression analysis.
  
  
  RESULTS
  Overall, 13.7% of the population (n = 512) reported non-compliance, with 10.7% reporting under-compliance and 4.3% reporting over-compliance. A number of patients reported both under- and over-compliance. Being prescribed bronchodilators, for example, was found to be associated with under-compliance, while being prescribed analgesics (excluding non-steroidal anti-inflammatories) was associated with over-compliance using Chi-square analysis. A five-variable non-compliance risk model was obtained from logistic regression analysis. This model had a specificity of 88.9% and a sensitivity of 33.3%. The factors shown to influence compliance were the type of drug being taken (diuretics, bronchodilators and benzodiazepines), independence when taking medicines and the number of non-prescription drugs being taken. All other laboratory/test data, diseases/diagnoses, reasons for hospital admission and socio-demographic factors were not significant risk factors for self-reported non-compliance in the present model.
  
  
  CONCLUSIONS
  Although it is accepted that self-reporting of poor compliance is generally lower than actual poor compliance, the present risk model provides further insight into the drug-taking habits of elderly patients.
authors.affiliation: School of Pharmacy, Queen's University of Belfast, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: McElnay
authors.forename: C R
authors.initials: CR
authors.lastname: McCallion
authors.forename: F
authors.initials: F
authors.lastname: al-Deagi
authors.forename: M
authors.initials: M
authors.lastname: Scott
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D015233:Models, Statistical; D015999:Multivariate Analysis; D010349:Patient Compliance