title: A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells.
abstract: In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2,3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1 beta,2 beta-diacetoxy-6 alpha,9 alpha-bis(benzoyloxy)dihydro-beta-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.
authors.affiliation: Natural Product & Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.
authors.forename: S E
authors.initials: SE
authors.lastname: Kim
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: J J
authors.initials: JJ
authors.lastname: Lee
authors.forename: Y C
authors.initials: YC
authors.lastname: Kim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000502:physiology; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D006801:Humans; D012717:Sesquiterpenes; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C110798:1,2-diacetoxy-6,9-bis(benzoyloxy)dihydro-beta-agarofuran; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D014315:Triterpenes