title: Interpreting open- and closed-loop transfer relations between cardiorespiratory parameters: lessons learned from a computer model of beat-to-beat cardiovascular regulation.
abstract: A computer model of cardiovascular control has been developed based on the response characteristics of cardiovascular control components derived from experiments in animals and humans. Results from the model were compared to those obtained experimentally in humans, and the similarities and differences were used to identify both the strengths and inadequacies of the concepts used to form the model. Findings were confirmatory of some concepts but contrary to some which are firmly held in the literature, indicating that understanding the complexity of cardiovascular control probably requires a combination of experiments and computer models which integrate multiple systems and allow for determination of sufficiency and necessity.
authors.affiliation: Boston University, Children's Hospital, Department of Cardiology, Harvard Medical School, MA, USA. hammer_p@al.tch.harvard.edu
authors.forename: P
authors.initials: P
authors.lastname: Hammer
authors.forename: D
authors.initials: D
authors.lastname: Litvack
authors.forename: J P
authors.initials: JP
authors.lastname: Saul
mesh_terms: D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D012815:Signal Processing, Computer-Assisted; D013597:Systems Analysis