title: The role of methylmethacrylate monomer in the formation and haemodynamic outcome of pulmonary fat emboli.
abstract: We examined the roles of methylmethacrylate (MMA) monomer and cementing technique in the formation, and haemodynamic outcome, of pulmonary fat emboli. The preparation of the femoral canal and the cementing technique were studied in four groups of adult dogs as follows: control (no preparation); lavage; cement pressurisation; and cement pressurisation after lavage. We measured the intramedullary pressure, pulmonary artery pressure (PAP), pulmonary capillary wedge pressure and bilateral femoral vein levels of triglyceride, cholesterol and MMA monomer at rest and after reaming, lavage, and cementing. Femoral vein triglyceride and cholesterol levels did not vary significantly from resting levels despite significant elevations in intramedullary pressure with reaming, lavage and cementing (p = 0.001). PAP was seen to rise significantly with reaming (p = 0.0038), lavage (p = 0.0031), cementing (p = 0.0024) and cementing after lavage (p = 0.0028) while the pulmonary capillary wedge pressure remained unchanged. MMA monomer was detected in femoral vein samples when cement pressurisation was used. Intramedullary lavage before cementing had no significant effect on the MMA level. Haemodynamic evidence of pulmonary embolism was noted with reaming and intramedullary canal preparation, irrespective of the presence of MMA monomer. We found no relationship between MMA monomer level and intramedullary pressure, PAP or pulmonary capillary wedge pressure. Our findings suggest that the presence of MMA monomer in femoral venous blood has no effect on the formation of fat emboli or their pulmonary haemodynamic outcome during cemented hip arthroplasty.
authors.affiliation: St Michael's Hospital and the University of Toronto, Ontario, Canada.
authors.forename: A W
authors.initials: AW
authors.lastname: Elmaraghy
authors.forename: B
authors.initials: B
authors.lastname: Humeniuk
authors.forename: G I
authors.initials: GI
authors.lastname: Anderson
authors.forename: E H
authors.initials: EH
authors.lastname: Schemitsch
authors.forename: R R
authors.initials: RR
authors.lastname: Richards
mesh_terms: D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D001843:Bone Cements / Q000009:adverse effects*; D002784:Cholesterol / Q000097:blood; D004285:Dogs; D004620:Embolism, Fat / Q000139:chemically induced*; D005260:Female; D005269:Femur; D006439:Hemodynamics; D008297:Male; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000009:adverse effects*; D011312:Pressure; D011655:Pulmonary Embolism / Q000139:chemically induced*; D012119:Respiration; D014280:Triglycerides / Q000097:blood
chemical_list: D001843:Bone Cements; D008768:Methylmethacrylates; D014280:Triglycerides; D020366:Methylmethacrylate; D002784:Cholesterol