title: Raman spectroscopy and fluorescence photon migration for breast cancer diagnosis and imaging.
abstract: We are developing optical methods based on near infrared Raman spectroscopy and fluorescence photon migration for diagnosis and localization of breast cancer. We demonstrate the ability of Raman spectroscopy to classify accurately normal, benign and malignant breast tissues, an important step in developing Raman spectroscopic needle probes as a tool for improving the accuracy of needle biopsy. We also show that photon migration imaging can be used to localize accurately small fluorescent objects imbedded in a thick turbid medium with realistic optical properties, thus demonstrating the potential of this technique for optical imaging.
authors.affiliation: George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA. rmanohar@mit.edu
authors.forename: R
authors.initials: R
authors.lastname: Manoharan
authors.forename: K
authors.initials: K
authors.lastname: Shafer
authors.forename: L
authors.initials: L
authors.lastname: Perelman
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Deinum
authors.forename: M
authors.initials: M
authors.lastname: Fitzmaurice
authors.forename: J
authors.initials: J
authors.lastname: Myles
authors.forename: J
authors.initials: J
authors.lastname: Crowe
authors.forename: R R
authors.initials: RR
authors.lastname: Dasari
authors.forename: M S
authors.initials: MS
authors.lastname: Feld
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D005453:Fluorescence; D006801:Humans; D017785:Photons; D012542:Scattering, Radiation; D019265:Spectroscopy, Near-Infrared; D013059:Spectrum Analysis, Raman; D014054:Tomography / Q000379:methods*