Calcitonin gene-related peptide (CGRP) and hypertrophy of cardiomyocytes.
We studied whether calcitonin gene-related peptide (CGRP), a neuropeptide secreted from the sensory nervous supply to the myocardium, induces hypertrophy of cardiomyocytes in culture. CGRP increased the cell surface area of neonatal rat cardiomyocytes; the surface area of the cells was almost doubled by treatment with CGRP for 48 h. Furthermore, CGRP up-regulated mRNA expression for skeletal alpha-actin and atrial natriuretic peptides, which are genetic markers for cardiac hypertrophy. These results indicate that CGRP is a potent hypertrophic factor for cardiomyocytes.
Ito
H
H
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Bell
D
D
Tamamori
M
M
Nozato
T
T
Shimojo
T
T
Adachi
S
S
Abe
S
S
Marumo
F
F
Hiroe
M
M
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D006332:Cardiomegaly / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D006801:Humans; D017379:Hypertrophy, Left Ventricular; D009206:Myocardium / Q000166:cytology* / Q000473:pathology; D051381:Rats
D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D015740:Calcitonin Gene-Related Peptide