Alu elements as an aid in deciphering genome rearrangements.
Genomic rearrangements result in genomic duplications that lead to the generation of more complex genomes. Some attempts have been made to trace duplication histories of different loci using Alu elements because of their large population in primate genomes (Chen et al., 1989; Mnuková-Fajdelová et al., 1994). In this short report, using the human growth hormone locus as an example, we demonstrate the usefulness of Alu repetitive elements in computer sequence analyses when tracing duplication histories. Information on subfamily classification, direction, arrangements, Poly(A) tails and direct repeats can aid our understanding of genome rearrangements.
Toda
Y
Y
Laboratory of Bioinformatics, Keio University, Fujisawa, Kanagawa, Japan.
Tomita
M
M
D002874:Chromosome Mapping; D019143:Evolution, Molecular; D015321:Gene Rearrangement; D016678:Genome; D013006:Growth Hormone / Q000235:genetics; D006801:Humans; D012091:Repetitive Sequences, Nucleic Acid
D013006:Growth Hormone