title: Age-related mortality, clinical heart failure, and ventricular fibrillation in 4259 Danish patients after acute myocardial infarction.
abstract: OBJECTIVE
  To evaluate the prognosis of patients > or = 80 years old, we analysed a large, community-based population with acute myocardial infarction who received intensive observation and similar pharmacotherapy regardless of age.
  
  
  RESULTS
  In a 12-year period, before the introduction of thrombolysis, 4259 consecutive patients hospitalized with acute myocardial infarction from the same hospital in Denmark were prospectively registered. Their complications and mortality in hospital, and 1 and 5 years after discharge were analysed retrospectively. Overall, in-hospital mortality was 11% for patients less than < 50 years old, 22% for patients 60-69 years old and 43% for patients > or = 80 years old. Two thirds of patients > or = 80 years old had heart failure, and cardiogenic shock was twice as common in this age group than in patients 60-69 years. Heart failure was a strong independent risk, factor for post-discharge mortality, particularly in the oldest age groups. Four out of eight patients > or = 80 years survived one year if discharged alive after experiencing in-hospital ventricular fibrillation.
  
  
  CONCLUSIONS
  The life-saving potential of preventing or treating heart failure seems considerable even in the oldest patient groups. Patients > or = 80 years old who survive in-hospital ventricular fibrillation have an acceptable prognosis 1 year post-discharge.
authors.affiliation: Department of Cardiology Glostrup University Hospital of Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Rask-Madsen
authors.forename: G
authors.initials: G
authors.lastname: Jensen
authors.forename: L
authors.initials: L
authors.lastname: Køber
authors.forename: T
authors.initials: T
authors.lastname: Melchior
authors.forename: C
authors.initials: C
authors.lastname: Torp-Pedersen
authors.forename: P
authors.initials: P
authors.lastname: Hildebrand
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003718:Denmark / Q000453:epidemiology; D048909:Diabetes Complications; D005260:Female; D006333:Heart Failure / Q000209:etiology*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications* / Q000401:mortality*; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis; D014693:Ventricular Fibrillation / Q000209:etiology*