[TSH-receptor blocking antibodies in juvenile thyrotoxicosis].
The case presented is a 12 year-old girl with hyperthyroidism due to juvenile Grave's disease, who during the course of treatment developed hypothyroidism due to TSH-receptor blocking antibodies, measured by bioassay. The bioassay used was performed on CHO-R cells measuring c-AMP. The role of radioreceptor assays and bioassays in measuring TSH receptor antibodies in hyper- and hypothyroid Graves' disease in discussed.
Nielsen
L H
LH
Odense Universitetshospital, børneafdeling H.
Jacobsen
B B
BB
Fiore
E
E
D000367:Age Factors; D019138:Antibodies, Blocking / Q000032:analysis; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects; D002648:Child; D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology*; D008713:Methimazole / Q000008:administration & dosage / Q000009:adverse effects; D011989:Receptors, Thyrotropin / Q000276:immunology*; D013974:Thyroxine / Q000008:administration & dosage / Q000009:adverse effects
D019138:Antibodies, Blocking; D013956:Antithyroid Agents; D011989:Receptors, Thyrotropin; D008713:Methimazole; D013974:Thyroxine
TSH-receptorblokerende antistoffer ved juvenil tyreotoksikose.