title: [A case of advanced gastric cancer with multiple bone metastasis successfully treated by both methotrexate and 5-fluorouracil sequential therapy, and endoscopic intratumoral injection of 5-fluorouracil].
abstract: We reported a case of advanced gastric cancer with multiple bone metastasis successfully treated by both methotrexate (MTX) and 5-fluorouracil (5-FU) sequential therapy, and endoscopic intratumoral injection of 5-fluorouracil. A 38-year-old man was admitted to our hospital complaining of appetite loss and bone pain. He could not walk by himself for the bone pain. Upper gastrointestinal endoscopy revealed a lesion like II c + III in the greater curvature of the angulus. By both MTX /5-FU sequential therapy and endoscopic intratumoral injection of 5-FU, partial response (PR) was obtained against gastric primary lesion, and his performance status was improved. PR was maintained for 5 months. Severe side effects of the chemotherapy were not observed.
authors.affiliation: Third Dept. of Internal Medicine, Kagawa Medical University.
authors.forename: K
authors.initials: K
authors.lastname: Sasahara
authors.forename: Y
authors.initials: Y
authors.lastname: Uchida
authors.forename: M
authors.initials: M
authors.lastname: Kamei
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Kawabata
authors.forename: M
authors.initials: M
authors.lastname: Nishioka
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary*; D010478:Chemotherapy, Cancer, Regional Perfusion; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D005773:Gastroscopy; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D005472:Fluorouracil; D008727:Methotrexate