Excitability of the central masticatory pathways in patients with painful temporomandibular disorders.
Much is unclear about the pathophysiological mechanisms underlying painful temporomandibular disorders. In addition to various other theories, masticatory muscle dysfunction and pain have also been attributed to primary central nervous system hyperactivity. We assessed this possibility in a study using recent neurophysiological techniques. From among outpatients whose diagnosis of temporomandibular disorders had been obtained in stomatognathic facilities, we studied 10 patients with bilateral pain and 15 patients with unilateral pain, in whom electromyographic examination of the trigeminal reflexes disclosed normal findings except for absence or amplitude asymmetry of the jaw jerk. Transcranial magnetic stimulation yielded masseter motor evoked potentials of normal latency and amplitude, but five patients had to exert a near-maximum contraction to obtain their responses. The masseter silent periods elicited by the double-shock technique recovered normally. Because these tests measure the excitability of the masticatory system (including motor cortex, corticobulbar and corticoreticular connections, reticular interneurones and lower motoneurones), the lack of facilitation in these patients' responses excluded central hyperactivity as the primary cause of their masticatory dysfunction and pain.
Cruccu
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Dipartimento Scienze Neurologiche, Università 'La Sapienza', Viale Università 30, I-00185 Roma, Italy Servizio Diagnosi e Terapia del Dolore, Università 'La Sapienza', Roma, Italy Ospedale GB Grassi, Ostia, Italy Centro Interuniversitario per la Neurofisiologia del Dolore (CIND), Genova, Italy.
Frisardi
G
G
Pauletti
G
G
Romaniello
A
A
Manfredi
M
M
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D019054:Evoked Potentials, Motor / Q000502:physiology*; D006801:Humans; D008280:Magnetics; D008334:Mandible / Q000502:physiology; D008406:Masseter Muscle / Q000502:physiology*; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012026:Reflex, Stretch / Q000502:physiology; D013284:Stomatognathic System / Q000502:physiology*; D013705:Temporomandibular Joint Disorders / Q000150:complications / Q000503:physiopathology*