Early postnatal hypoglycaemia in newborn infants of diabetic mothers.
This study found that early postnatal hypoglycaemia was mainly induced by foetal hyperinsulinaemia, in close relation to maternal hyperglycaemia, even in well-controlled pregnancies of 59 mothers with insulin-treated diabetes mellitus, 29 with insulin-dependent diabetes mellitus and 30 with gestational diabetes mellitus. Ten of the newborn children (17%) had a blood glucose concentration below 1.0 mmol l(-1) at 2 h postnatally. Cord insulin-like growth factor-I or glucagon concentrations were not related to the early decline of blood glucose.
Stenninger
E
E
Department of Paediatrics, Orebro Medical Centre Hospital, Sweden.
Schollin
J
J
Aman
J
J
D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy; D016640:Diabetes, Gestational / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005934:Glucagon / Q000032:analysis; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D011181:Postnatal Care; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications* / Q000188:drug therapy; D013548:Sweden / Q000453:epidemiology
D001786:Blood Glucose; D005934:Glucagon; D006442:Glycated Hemoglobin; D007334:Insulin-Like Growth Factor I