title: Outcome of treatment of upper third vaginal recurrences of cervical and endometrial carcinomas with interstitial brachytherapy.
abstract: OBJECTIVE
  To describe an original brachytherapy technique using a dedicated intravaginal template for the treatment of vaginal vault recurrences and to evaluate the results of such a treatment.
  
  
  METHODS
  Between 1978 and 1993, 78 patients with isolated recurrence of cervical or endometrial carcinoma located in the vaginal vault have been treated in Lyon. Initial treatment was surgery alone in 49 cases and irradiation with surgery in 37 cases. Treatment of the vaginal recurrence was performed with interstitial Iridium 192 brachytherapy combined with pelvic external beam radiation therapy in 34 patients. The tumor was implanted with a dedicated intravaginal plastic template. Six parallel metallic needles were implanted in the vaginal vault and afterloaded with Iridium 192 wires of 4 to 6 cm long. The mucosa of the upper half of the vagina received the same dose as the one encompassing the tumor on the 85% isodose of the Paris system.
  
  
  RESULTS
  At 5 years the local control rate was 70% and the overall survival rate 56%. Grade 3 complications occurred in 10% of the cases and only in patients who had received irradiation during the initial treatment of the primary tumor.
  
  
  CONCLUSIONS
  This brachytherapy technique makes it possible to perform Iridium 192 implants in a difficult situation with a favorable long-term control rate and an acceptable rate of complications.
authors.affiliation: Service de Radiothérapie-Oncologie, Centre Hospitalier Lyon-Sud, Pierre Bénite, France.
authors.forename: C
authors.initials: C
authors.lastname: Charra
authors.forename: P
authors.initials: P
authors.lastname: Roy
authors.forename: R
authors.initials: R
authors.lastname: Coquard
authors.forename: P
authors.initials: P
authors.lastname: Romestaing
authors.forename: J M
authors.initials: JM
authors.lastname: Ardiet
authors.forename: J P
authors.initials: JP
authors.lastname: Gérard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D016889:Endometrial Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy*; D012074:Remission Induction; D015996:Survival Rate; D016896:Treatment Outcome; D014625:Vaginal Neoplasms / Q000401:mortality / Q000532:radiotherapy*
chemical_list: D007496:Iridium Radioisotopes