title: [Anti Ko(a) as a cause of neonatal alloimmune thrombocytopenia].
abstract: Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal immunization against a paternal antigen on fetal platelets. The antigens mostly involved are Zwa (PlA1) and Br(a). The Ko alloantigen system which is localized on the N-terminal region of glycoprotein Ib usually causes antibody formation in polytransfused patients but is only rarely implicated in NAIT. Ko(a) antibodies raised in the mother of a thrombocytopenic newborn were shown to be detectable by platelet agglutination and MAIPA assay if the antigen-bearing N-terminal glycocalicin is protected from proteolytic degradation.
authors.affiliation: Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen, Deutschland.
authors.forename: H
authors.initials: H
authors.lastname: Kroll
authors.forename: W
authors.initials: W
authors.lastname: Muntean
authors.forename: V
authors.initials: V
authors.lastname: Kiefel
authors.forename: A
authors.initials: A
authors.lastname: Giptner
authors.forename: C
authors.initials: C
authors.lastname: Schlüter
authors.forename: S
authors.initials: S
authors.lastname: Santoso
authors.forename: C
authors.initials: C
authors.lastname: Mueller-Eckhardt
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology; D011247:Pregnancy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*
chemical_list: C071221:2b alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies; D019038:Platelet Glycoprotein GPIb-IX Complex
vernacular_title: Anti-Ko(a) als Ursache der neonatalen Alloimmunthrombozytopenie.