Effects of bromocriptine and terguride on cell proliferation and apoptosis in the estrogen-stimulated anterior pituitary gland of the rat.
The effects of bromocriptine and terguride on the estrogen-stimulated anterior pituitary gland of the female Wistar rat were investigated. Pituitary weight and serum prolactin (PRL) levels were reduced by treatment with bromocriptine or terguride. Immunohistological staining for proliferating cell nuclear antigen (PCNA) revealed that the PCNA labeling index of PRL-producing cells was significantly decreased by treatment with bromocriptine or terguride compared with untreated cells. The number of apoptotic cells analyzed by the terminal deoxynucleotidyl transferase-mediated deoxyuridinetriphosphate-biotin nick end labeling method was significantly increased in rats treated with bromocriptine or terguride. Suppression of cell proliferation and induction of apoptosis are important effects of bromocriptine and terguride in the treatment of prolactinomas and other hyperprolactinemias.
Yonezawa
K
K
Department of Neurosurgery, Kobe University School of Medicine.
Tamaki
N
N
Kokunai
T
T
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000276:immunology; D001971:Bromocriptine / Q000494:pharmacology* / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002464:Cell Migration Inhibition; D018491:Dopamine Agonists / Q000494:pharmacology* / Q000627:therapeutic use*; D004958:Estradiol / Q000502:physiology*; D005260:Female; D006727:Hormone Antagonists / Q000494:pharmacology* / Q000627:therapeutic use*; D008090:Lisuride / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D009360:Neoplastic Cells, Circulating / Q000187:drug effects / Q000473:pathology; D010902:Pituitary Gland / Q000187:drug effects*; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D015175:Prolactinoma / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000187:drug effects / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar
D018491:Dopamine Agonists; D006727:Hormone Antagonists; D018809:Proliferating Cell Nuclear Antigen; C006208:dironyl; D001971:Bromocriptine; D004958:Estradiol; D008090:Lisuride