In vitro cytotoxic effect of new diphenylphosphinoethane-copper(I) complexes on human ovarian carcinoma cells.
Five new copper (I) complexes have been tested for their, in vitro cytotoxicity on chinese hamster ovary (CHO) and human ovarian carcinoma PA-1 cell lines using MTT assay. The compounds exhibited encouraging cytotoxicity at of 1, 2, 4 & 8 micrograms/ml doses. They were further tested for cytotoxicity on human ovarian carcinoma cells obtained from five different patients previously untreated with antineoplastic drugs and radiation. Standard antitumor drugs like cis-platin, adriamycin and etoposide were also included as positive control. Cytotoxicity of compounds C3, C4 and C5 (IC50 0.7, 1.25 and 1.4 micrograms/ml respectively) was found to be superior to adriamycin (IC50 2.8 micrograms/ml) but less effective than cisplatin (IC50 < 0.1 microgram/ml) on human ovarian carcinoma cells.
Adwankar
M K
MK
Chemotherapy & Stem Cell Biology Division, Tata Memorial Centre, Parel, Bombay, India.
Wycliff
C
C
Samuelson
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016466:CHO Cells; D006224:Cricetinae; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D009942:Organometallic Compounds / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; C069605:bis(1,2-bis-(diphenylphosphino)ethane)Cu(I)