title: Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone: a case treated by steroid therapy.
abstract: We report a case of giant cell tumor of bone (GCTB) associated with Paget's disease unsuccefully treated with radiotherapy for some years but dramatically reduced in size with high dose of dexamethasone within few days. An ultrastructural study showed intranuclear virus-like inclusions in the multinucleated giant cells. The patient was then switched to prednisone plus diclofenac and he is still in almost complete remission after two years. The patient was from Avellino area, a small town in Southern Italy.
authors.affiliation: Servizio di Anatomia Patologia, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione, Via M. Semmola, Napoli, 80131, Italy.
authors.forename: A
authors.initials: A
authors.lastname: De Chiara
authors.forename: G
authors.initials: G
authors.lastname: Apice
authors.forename: F
authors.initials: F
authors.lastname: Fazioli
authors.forename: P
authors.initials: P
authors.lastname: Silvestro
authors.forename: G
authors.initials: G
authors.lastname: Carone
authors.forename: A
authors.initials: A
authors.lastname: Manco
mesh_terms: D002467:Cell Nucleus / Q000648:ultrastructure / Q000821:virology; D018212:Giant Cell Tumor of Bone / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D015726:Giant Cells / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications*; D011239:Prednisolone / Q000627:therapeutic use*; D012888:Skull Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone