title: Application of color Doppler M-mode echocardiography in the assessment of ventricular diastolic function: potential for quantitative analysis.
abstract: Color Doppler M-mode echocardiography provides a spatiotemporal map of blood distribution (v(s,t)) within the heart, with a typical temporal resolution of 5 ms, a spatial resolution of 300 microns, and a velocity resolution of 3 cm/s. M-mode echocardiographic data can be obtained along a streamline from the mid-left atrium to the mid-left ventricle from either the apical transthoracic window or the basal transesophageal window. A key parameter of the color Doppler M-mode is the transmitral propagation velocity, the slope of the leading edge of the M-mode derived E-wave. This propagation velocity is significantly less than the velocities measured within the E-wave by pulsed Doppler echocardiography and appears to provide important independent information about left ventricular filling pressures and diastolic function. Furthermore, color M-mode velocities can be processed quantitatively by the Euler equation to yield estimates of the small (< 2 mmHg) pressure gradients between the base and apex during filling, the first time such gradients have been measured noninvasively.
authors.affiliation: Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Thomas
authors.forename: M J
authors.initials: MJ
authors.lastname: Garcia
authors.forename: N L
authors.initials: NL
authors.lastname: Greenberg
mesh_terms: D003971:Diastole; D018618:Echocardiography, Doppler, Color; D006321:Heart / Q000502:physiology; D006801:Humans; D012039:Regional Blood Flow; D016277:Ventricular Function, Left; D017725:Ventricular Pressure