title: A new antiplatelet diarylheptanoid from Alpinia blepharocalyx.
abstract: A new diarylheptanoid, 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (1), along with seven other known compounds, were isolated from the seeds of Alpinia blepharocalyx. Of these, compounds 1 and 3 showed strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood. Compound 3 also strongly inhibited ristocetin-induced platelet aggregation. Structures of these compounds were elucidated by spectroscopic and chemical means.
authors.affiliation: Bioscience Centre, National University of Singapore, Singapore.
authors.forename: H
authors.initials: H
authors.lastname: Doug
authors.forename: S X
authors.initials: SX
authors.lastname: Chen
authors.forename: H X
authors.initials: HX
authors.lastname: Xu
authors.forename: S
authors.initials: S
authors.lastname: Kadota
authors.forename: T
authors.initials: T
authors.lastname: Namba
mesh_terms: D002681:China; D036381:Diarylheptanoids; D006801:Humans; D066298:In Vitro Techniques; D007659:Ketones / Q000302:isolation & purification* / Q000494:pharmacology; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry
chemical_list: C110805:1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one; D036381:Diarylheptanoids; D007659:Ketones; D010636:Phenols; D010975:Platelet Aggregation Inhibitors