title: Relationship of manometric findings to symptomatic response after pneumatic dilation in achalasia cardia.
abstract: BACKGROUND
  Achalasia cardia is usually treated by pneumatic dilation or surgical esophagomyotomy. The role of esophageal manometry for objective assessment of symptom response is controversial.
  
  
  OBJECTIVE
  To study the relationship between symptoms and manometric parameters before and after pneumatic dilation in patients with achalasia cardia.
  
  
  METHODS
  Sixteen patients with achalasia cardia underwent esophageal manometry before and after undergoing pneumatic dilation. At each time, lower esophageal sphincter (LES) pressure and mean basal esophageal-gastric pressure gradient (MIEP-MIGP) were measured.
  
  
  RESULTS
  Good symptom response was obtained in 12 of 16 patients. Median (range) LES pressure fell from 42 (17-51) mmHg to 18 (8-39) mmHg in those patients with a good response, and from 51 (25-68) mmHg to 29.5 (23-42) mmHg in those who responded poorly. Mean intraesophageal pressure fell below mean intragastric pressure in both the groups.
  
  
  CONCLUSIONS
  Esophageal manometry does not correlate with symptom improvement after pneumatic dilation in achalasia cardia. Dysphagia may persist in spite of reversal of the MIEP-MIGP gradient.
authors.affiliation: Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow.
authors.forename: H M
authors.initials: HM
authors.lastname: Shahi
authors.forename: R
authors.initials: R
authors.lastname: Aggarwal
authors.forename: A
authors.initials: A
authors.lastname: Misra
authors.forename: D K
authors.initials: DK
authors.lastname: Agarwal
authors.forename: S R
authors.initials: SR
authors.lastname: Naik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004106:Dilatation / Q000379:methods*; D004931:Esophageal Achalasia / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011446:Prospective Studies