title: Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.
abstract: A locus for Peutz-Jeghers syndrome (PJS) was recently mapped to chromosome 19p13.3. Each of 12 families studied was compatible with linkage to the marker D19S886. We have analysed 20 further families and found that the majority of these are consistent with a PJS gene on 19p13.3. Three families were, however, unlinked to 19p13.3 and none of the available PJS polyps from these families showed allele loss at D19S886. There were no obvious clinicopathological or ethnic differences between the 19p13.3 linked and unlinked families. There appears, therefore, to be a major PJS locus on chromosome 19p13.3 and the possibility exists of a minor locus (or loci) elsewhere.
authors.affiliation: INSERM U-434, CEPH, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Olschwang
authors.forename: D
authors.initials: D
authors.lastname: Markie
authors.forename: S
authors.initials: S
authors.lastname: Seal
authors.forename: K
authors.initials: K
authors.lastname: Neale
authors.forename: R
authors.initials: R
authors.lastname: Phillips
authors.forename: S
authors.initials: S
authors.lastname: Cottrell
authors.forename: I
authors.initials: I
authors.lastname: Ellis
authors.forename: S
authors.initials: S
authors.lastname: Hodgson
authors.forename: P
authors.initials: P
authors.lastname: Zauber
authors.forename: A
authors.initials: A
authors.lastname: Spigelman
authors.forename: T
authors.initials: T
authors.lastname: Iwama
authors.forename: S
authors.initials: S
authors.lastname: Loff
authors.forename: C
authors.initials: C
authors.lastname: McKeown
authors.forename: C
authors.initials: C
authors.lastname: Marchese
authors.forename: J
authors.initials: J
authors.lastname: Sampson
authors.forename: S
authors.initials: S
authors.lastname: Davies
authors.forename: I
authors.initials: I
authors.lastname: Talbot
authors.forename: J
authors.initials: J
authors.lastname: Wyke
authors.forename: G
authors.initials: G
authors.lastname: Thomas
authors.forename: W
authors.initials: W
authors.lastname: Bodmer
authors.forename: A
authors.initials: A
authors.lastname: Hemminki
authors.forename: E
authors.initials: E
authors.lastname: Avizienyte
authors.forename: A
authors.initials: A
authors.lastname: de la Chapelle
authors.forename: L
authors.initials: L
authors.lastname: Aaltonen
authors.forename: I
authors.initials: I
authors.lastname: Tomlinson
mesh_terms: D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D005260:Female; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010375:Pedigree; D010580:Peutz-Jeghers Syndrome / Q000235:genetics*
chemical_list: D005819:Genetic Markers