Salivary IgA responses to bacteria in dental plaque as related to periodontal and HIV infection status.
Levels of total IgA and specific IgA reactive with Streptococcus mutans, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens and Fusobacterium nucleatum were measured by ELISA in parotid saliva from HIV+ and HIV- persons with healthy gingiva (HG), chronic gingivitis, chronic marginal periodontitis (CMP), or necrotizing ulcerative periodontitis (NUP). When the HIV+ group was compared with the HIV- group regardless of periodontal status, total salivary IgA concentration was higher in HIV+ patients, but no such difference was observed for total IgA output. HIV+ CMP displayed higher total IgA concentration as compared with HIV- CMP. No significant differences in specific IgA outputs and ratios were detected between HIV+ and HIV- subgroups with similar periodontal status. HIV+ NUP displayed increased specific IgA output towards S. mutans and increased specific IgA ratio values towards S. mutans, P. gingivalis and P. nigrescens as compared with HIV+ CMP, and increased specific IgA ratio values towards S. mutans and P. nigrescens as compared with HIV+ HG. No such differences were observed between the HIV- subgroups. In sum, salivary IgA responses to bacteria in dental plaque seem not to be related to chronic periodontal disease and HIV infection, but are possibly influenced by acute periodontal infection.
Myint
M M
MM
Department of Oral Biology, Dental Faculty, University of Oslo, Norway. myintm@odont.uio.no
Steinsvoll
S
S
Odden
K
K
Dobloug
J
J
Schenck
K
K
D000328:Adult; D000368:Aged; D016976:Aggregatibacter actinomycetemcomitans / Q000276:immunology; D000907:Antibodies, Bacterial / Q000032:analysis*; D002908:Chronic Disease; D003773:Dental Plaque / Q000276:immunology / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016967:Fusobacterium nucleatum / Q000276:immunology; D005881:Gingiva / Q000276:immunology; D005884:Gingival Hemorrhage / Q000276:immunology; D005891:Gingivitis / Q000276:immunology* / Q000382:microbiology; D015658:HIV Infections / Q000276:immunology*; D018023:HIV Seronegativity; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010306:Parotid Gland; D017622:Periodontal Attachment Loss / Q000276:immunology; D010518:Periodontitis / Q000276:immunology* / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000276:immunology; D018713:Prevotella intermedia / Q000276:immunology; D012463:Saliva / Q000276:immunology; D013295:Streptococcus mutans / Q000276:immunology; D014456:Ulcer
D000907:Antibodies, Bacterial; D007071:Immunoglobulin A, Secretory