Vincristine therapy for mast cell tumors in dogs.
Twenty-seven dogs with naturally occurring mast cell tumors were treated with weekly i.v. injections of vincristine (0.75 mg/m2) for 4 treatments. Two dogs (7%) had a partial response. Nine dogs (32%) had treatment stopped prematurely because of toxicity or a perceived deterioration in their quality of life. We conclude that vincristine is ineffective as a sole treatment for measurable mast cell tumors in dogs and produces an undesirable number of adverse reactions.
McCaw
D L
DL
Department of Veterinary Medicine and Surgery, University of Missouri, Columbia 65211, USA.
Miller
M A
MA
Bergman
P J
PJ
Withrow
S J
SJ
Moore
A S
AS
Knapp
D W
DW
Fowler
D
D
Johnson
J C
JC
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D012515:Mast-Cell Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D009919:Orchiectomy; D010052:Ovariectomy; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use*
D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine