Nonprogressive CMV retinitis in AIDS patients with protease inhibitors therapy for AIDS.
Cytomegalovirus (CMV) retinitis is the most common opportunistic viral infection in acquired immunodeficiency syndrome (AIDS) patients with a low CD4+ count. Without specific treatment, the disease is an important cause of blindness. We report two cases of AIDS with nonprogressive CMV retinitis after undergoing a combined antiHIV treatment schedule including at least one protease inhibitor. The treatment was associated with an increase in circulating CD4+ lymphocytes. This newly available antiviral combination may well prevent the recurrence of CMV disease and decrease the morbidity of CMV retinitis.
Ortega-Larrocea
G
G
Uveitis Department, Asociación para Evitar la Ceguera en México, México, D.F.
Feregrino-Goyos
M
M
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D004359:Drug Therapy, Combination; D005654:Fundus Oculi; D015774:Ganciclovir / Q000627:therapeutic use*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D019438:Ritonavir / Q000627:therapeutic use; D019258:Saquinavir / Q000627:therapeutic use
D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D019259:Lamivudine; D019258:Saquinavir; D019438:Ritonavir; D015774:Ganciclovir