title: [The regulatory aspects of the blood circulation in the placenta in physiological and complicated pregnancies].
abstract: New data about the development of placental circulation and the features of its regulation in normal and complicate pregnancy are considered in present review. Biochemical mechanisms leading to the dilatation of umbilical-placental circulation as well as the relaxation and contraction of placental vessels smooth muscles are discussed. It is shown that the disturbance of the balance between dilation and constriction factors being the results of injury of endothelial cells causes the spasm of uterine vessels, "delimiting" of maternal circulation from fetal one and proceeds a clinical manifestations of placental insufficiency. The data about the trophoblast autoimmune affection that underly to induction of autoimmune state of pre-eclampsia are described.
authors.forename: G L
authors.initials: GL
authors.lastname: Gromyko
authors.forename: A O
authors.initials: AO
authors.lastname: Shpakov
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000503:physiopathology; D005260:Female; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy / Q000502:physiology*; D011248:Pregnancy Complications / Q000503:physiopathology*; D011270:Pregnancy, Animal / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology
vernacular_title: Nekotorye aspekty reguliatsii krovoobrashcheniia v platsente pri fiziologicheskoĭ i oslozhnennoĭ beremennosti.