Reciprocal expression of mRNA for inhibin betaC and betaA subunits in hepatocytes.
Messenger RNA expression of activin betaC subunit in the liver was compared with that for betaA subunit before and after 70% hepatectomy. mRNA for betaC was abundantly expressed in the liver but decreased at 12 h and later after 70% hepatectomy, whereas that for betaA was increased 12 h after the hepatectomy. We also compared the expression of mRNA for betaA and betaC in cultured rat hepatocytes. mRNA for betaC subunit was abundantly expressed in the beginning of the culture but was reduced gradually after stimulation with epidermal growth factor. In contrast, mRNA for betaA subunit was undetectable before stimulation and was increased 24 to 48 h after stimulation with the mitogen. These results indicate that expression of mRNA for betaC and betaA is regulated differently. The role of activin C may be different from that of activin A in the liver.
Zhang
Y Q
YQ
Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Shibata
H
H
Schrewe
H
H
Kojima
I
I
D000818:Animals; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006498:Hepatectomy; D006801:Humans; D007265:Inhibins; D008099:Liver / Q000737:chemistry* / Q000166:cytology; D008115:Liver Regeneration / Q000235:genetics / Q000502:physiology; D008297:Male; D010455:Peptides / Q000235:genetics*; D029584:Prostatic Secretory Proteins; D012333:RNA, Messenger / Q000032:analysis* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D010455:Peptides; D029584:Prostatic Secretory Proteins; D012333:RNA, Messenger; C043076:beta-microseminoprotein; C094377:inhibin-alpha subunit; D007265:Inhibins; D004815:Epidermal Growth Factor