title: Malignant eccrine spiradenoma with carcinomatous and sarcomatous elements.
abstract: A case of a 60 year old man with malignant eccrine spiradenoma involving the perineum is described. Areas of typical eccrine spiradenoma were admixed with carcinomatous and sarcomatous elements. Immunohistochemical and ultrastructural analysis revealed no evidence of epithelial differentiation in the sarcomatous areas. The tumour qualified for the designation carcinosarcoma arising in eccrine spiradenoma. The clinical course was aggressive with rapid development of nodal and pulmonary metastases.
authors.affiliation: Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK.
authors.forename: W G
authors.initials: WG
authors.lastname: McCluggage
authors.forename: L J
authors.initials: LJ
authors.lastname: Fon
authors.forename: D
authors.initials: D
authors.lastname: O'Rourke
authors.forename: M
authors.initials: M
authors.lastname: Ismail
authors.forename: C M
authors.initials: CM
authors.lastname: Hill
authors.forename: T G
authors.initials: TG
authors.lastname: Parks
authors.forename: D C
authors.initials: DC
authors.lastname: Allen
mesh_terms: D006607:Adenoma, Sweat Gland / Q000473:pathology* / Q000648:ultrastructure; D002296:Carcinosarcoma / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000648:ultrastructure; D010502:Perineum; D013544:Sweat Gland Neoplasms / Q000473:pathology* / Q000648:ultrastructure