[Effect of the optimal neuroprotective doses of alpha2-adrenoreceptor agonists on the total cerebral blood flow in the normal conditions and in subsequent ischemia].
Optimal neuroprotective doses of clonidine and guanobenz considerably reduce the total cerebral blood flow and reduce or do not change arterial pressure. In occlusion of the carotid arteries the alpha 2-agonists fail to reduce the degree of cerebral ischemia and hypotension. The neuroprotective effect of alpha 2-adrenoceptor-agonists is not a result of cerebral blood flow improvement.
Kulinskiĭ
V I
VI
Irkutsk State Medical University, Russia.
Medvedeva
T N
TN
Usov
L A
LA
Ekimov
E N
EN
D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002545:Brain Ischemia / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D018696:Neuroprotective Agents; D003000:Clonidine
Vliianie optimal'nykh neĭroprotektornykh doz agonistov al'fa2-adrenoretseptorov na obshchiĭ krovotok v norme i pri posleduiushcheĭ ishemii.