title: Neuropathogenesis induced by rhesus cytomegalovirus in fetal rhesus monkeys (Macaca mulatta).
abstract: Rhesus cytomegalovirus (RhCMV) infection of rhesus macaques offers opportunities to analyze mechanisms of CMV pathogenesis in a primate species. Four fetal rhesus monkeys were inoculated intraperitoneally with RhCMV early in the second trimester, and pregnancies were terminated by hysterotomy during the third trimester. Three fetuses had evidence of severe CMV disease, including intrauterine growth restriction, ventriculomegaly, microcephaly, lissencephaly, and extensive degenerative changes of the cerebral parenchyma. Histopathologic examination revealed polymicrogyria, gliosis, leptomeningitis, periventricular calcifications, and inclusion-bearing cells. These results demonstrate that the developing macaque brain is susceptible to infection with RhCMV early in the second trimester and that intrauterine infection results in neuropathologic outcomes similar to those observed in humans congenitally infected with CMV.
authors.affiliation: California Regional Primate Research Center, Department of Pediatrics, University of California, Davis 95616-8542, USA. aftarantal@ucdavis.edu
authors.forename: A F
authors.initials: AF
authors.lastname: Tarantal
authors.forename: M S
authors.initials: MS
authors.lastname: Salamat
authors.forename: W J
authors.initials: WJ
authors.lastname: Britt
authors.forename: P A
authors.initials: PA
authors.lastname: Luciw
authors.forename: A G
authors.initials: AG
authors.lastname: Hendrickx
authors.forename: P A
authors.initials: PA
authors.lastname: Barry
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000821:virology; D001927:Brain Diseases / Q000196:embryology* / Q000473:pathology / Q000821:virology*; D002114:Calcinosis / Q000821:virology; D003586:Cytomegalovirus Infections / Q000196:embryology* / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005315:Fetal Diseases / Q000473:pathology / Q000821:virology*; D005865:Gestational Age; D005911:Gliosis / Q000821:virology; D008253:Macaca mulatta; D008581:Meningitis / Q000821:virology; D011247:Pregnancy