title: [A case of multiple endocrine neoplasia type I with primary hyperparathyroidism, prolactin secreting pituitary microadenoma and gastrin secreting duodenal carcinoid].
abstract: A case of MEN type I in a 64-year-old man is reported. He had undergone partial duodenectomy because of gastric ulcer and multiple duodenal polyps (gastrin secreting carcinoid). Blood examination revealed hypercalcemia, hyperPTHemia, and hyperprolactinemia. Neck US and CT showed enlargement of 4 parathyroid glands. Brain MRI revealed the microadenoma in left pituitary gland. Total parathyroidectomy with auto-transplantation in the left forearm were performed. Histological examination showed the hyperplasia of the parathyroid. Three and a half year after parathyroidectomy, there was no evidence of recurrence of gastrin secreting tumor and hyperparathyroidism, and enlargement of pituitary microadenoma. This is the first MEN type I case in Japan which have detected 3 endocrine tumors clinically with gastrin secreting duodenal carcinoid.
authors.affiliation: Department of Urology, Asahikawa Medical College.
authors.forename: M
authors.initials: M
authors.lastname: Tokumitsu
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Noda
authors.forename: A
authors.initials: A
authors.lastname: Numata
authors.forename: M
authors.initials: M
authors.lastname: Morikawa
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: S
authors.initials: S
authors.lastname: Yachiku
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D002276:Carcinoid Tumor / Q000378:metabolism*; D004379:Duodenal Neoplasms / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology*; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1; D010280:Parathyroid Glands / Q000473:pathology; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*
chemical_list: D005755:Gastrins; D011388:Prolactin