[The antioxidant systems in rheumatoid polyarthritis].
The inflammatory process from rheumatoid arthritis (RA) is marked by complexity, maintenance and destruction. The inflammatory lesions are induced by oxygen free radicals, that have a great capacity of destruction. We studied 52 patients with RA (defined by ARA criteria--1987). We have observed the inflammatory rheumatic syndrome, humoral and cellular immune syndrome and the antioxidant systems, i.e.: superoxidedismutaze, glutathione and its fractions, glutathione peroxidase, the total SH groups. We have observed the decrease of the glutathione in 40% of patients and the decrease of the total SH groups in 65% of patients. The total SH groups are correlated with the severe forms of the disease. Superoxide dismutase had decrease values in 85% of cases. We have remarked that the treatment with corticosteroids and D-penicillamina improved the serum levels of the glutathione and total SH groups.
Chiriac
R
R
Departamentul de Reumatologie şi Recuperare, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Rezuş
E
E
Florică
B
B
Chiriac
C
C
Bucur
B
B
Popârda
O
O
Mancaş
G
G
Palamaru
I
I
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000975:Antioxidants; D008054:Lipid Peroxides
Sistemele antioxidante în poliartrita reumatoidă.