[Effect of Rhodiola rosea on the yield of mutation alterations and DNA repair in bone marrow cells].
The study was made of the influence of the Rhodiola rosea extracts administration on chromosome aberrations, production of cells with micronuclei and unscheduled DNA synthesis in bone marrow cells of mice under action of mutagens cyclophosphamide and N-nitroso-N-methylurea (NMU). It was found that Rhodiola rosea extracts reduce significantly the yield of cells with the chromosome aberrations and micronuclei induced by cyclophosphamide in vivo, inhibit unscheduled DNA synthesis induced by NMU in vitro. It is emphasized that Rhodiola rosea extracts are antimutagens due to ability to raise the efficiency of the intracell DNA repair mechanisms.
Salikhova
R A
RA
Aleksandrova
I V
IV
Mazurik
V K
VK
Mikhaĭlov
V F
VF
Ushenkova
L N
LN
Poroshenko
G G
GG
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects*; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects*; D008297:Male; D051379:Mice; D009154:Mutation; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
D010936:Plant Extracts
Vliianie ékstraktov rodioly rozovoĭ na vykhod mutatsionnykh izmeneniĭ i reparatsiiu DNK v kletkakh kostnogo mozga.