title: Complement factors and their receptors.
abstract: In summary, recent advances in molecular cloning of anaphylatoxins and the anaphylatoxin receptors add new dimensions to our investigations and understanding of the molecular mechanisms involved in anaphylatoxin action. Combining knowledge accumulated from peptide modeling of the ligands with mutagenesis studies of these ligands and their receptors makes it possible to more accurately model interactive sites and understand the sequence of molecular interactions required for cellular activation. In addition, these new developments provide valuable tools for investigating, yet unknown, activities and cellular targets of the anaphylatoxin molecules.
authors.affiliation: Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Ember
authors.forename: T E
authors.initials: TE
authors.lastname: Hugli
mesh_terms: D000595:Amino Acid Sequence; D000706:Anaphylatoxins / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D000707:Anaphylaxis / Q000235:genetics / Q000276:immunology*; D000936:Antigen-Antibody Complex; D003001:Cloning, Molecular; D003167:Complement Activation / Q000235:genetics / Q000276:immunology*; D015926:Complement C3a / Q000031:analogs & derivatives / Q000235:genetics / Q000276:immunology; D015934:Complement C4a / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D015936:Complement C5a / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D016296:Mutagenesis / Q000235:genetics / Q000276:immunology; D011951:Receptors, Complement / Q000737:chemistry / Q000235:genetics* / Q000276:immunology
chemical_list: D000706:Anaphylatoxins; D000936:Antigen-Antibody Complex; D011951:Receptors, Complement; D015926:Complement C3a; D015934:Complement C4a; D015936:Complement C5a