Studies of metabolic control using NMR and molecular genetics.
The techniques of NMR spectroscopy and molecular genetics have provided new and powerful approaches to studying the control and organisation of cellular metabolism in vivo. We review here our recent applications of these methodologies to the study of energy metabolism in yeast and mammalian cells.
Brindle
K M
KM
Department of Biochemistry, University of Cambridge, UK.
Fulton
S M
SM
Gillham
H
H
Williams
S P
SP
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D008099:Liver / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008928:Mitochondria / Q000378:metabolism; D009132:Muscles / Q000201:enzymology; D010085:Oxidative Phosphorylation; D010732:Phosphofructokinase-1 / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D000255:Adenosine Triphosphate; D010732:Phosphofructokinase-1; D003402:Creatine Kinase