Protection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon.
The role of CD8 T cells in controlling Mycobacterium tuberculosis infections in mice was confirmed by comparing the levels of growth of the organism in control, major histocompatibility complex class II knockout, and athymic mice and by transferring T-cell populations into athymic mice. By using donor mice which were incapable of making gamma interferon (IFN-gamma), it was shown that IFN-gamma production was essential for CD8 cell mediation of protective immunity against M. tuberculosis.
Tascon
R E
RE
National Institute for Medical Research, London, United Kingdom.
Stavropoulos
E
E
Lukacs
K V
KV
Colston
M J
MJ
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D000949:Histocompatibility Antigens Class II / Q000502:physiology; D007371:Interferon-gamma / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008819:Mice, Nude; D014376:Tuberculosis / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007371:Interferon-gamma