Chronic toxicity studies of piperonyl butoxide in CD-1 mice: induction of hepatocellular carcinoma.
Male and female CD-1 mice (51-104 mice/group) were administered piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltol uene) in the diet at levels of 0 (control), 0.6 and 1.2% for 52 weeks (1 year). Hepatocellular carcinomas were induced in treated groups in a dose-dependent manner. The incidences of hepatocellular carcinoma were 11.3 and 52.0% in male mice given 0.6 and 1.2% piperonyl butoxide, and 41.2% in female mice given 1.2%. Piperonyl butoxide is thus a hepatocarcinogen to mice as it is known to be to rats.
Takahashi
O
O
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Oishi
S
S
Fujitani
T
T
Tanaka
T
T
Yoneyama
M
M
D000818:Animals; D015197:Carcinogenicity Tests; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000401:mortality; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010574:Pesticide Synergists / Q000633:toxicity*; D010882:Piperonyl Butoxide / Q000633:toxicity*
D010574:Pesticide Synergists; D010882:Piperonyl Butoxide