[The local immunoneuroendocrine system of the pancreas and the development of type-1 diabetes mellitus. A hypothesis].
It is suggested that the development of insulin-dependent diabetes mellitus (IDDM) is due to insufficiency of local immunoneuroendocrine system (LINES), which prevents development of the pathological process in the insular tissue at the very early stages. The further disbalance between LINES and CNS and development of pathology occurs with a very active involvement of immunocompetent cells and their effector molecules (autoantibodies, cytokines). We believe that finding of mechanisms of cell interactions inside LINES (beta-cells, neurons, lymphocytes and macrophages) at the early stages will serve a basis for IDDM prevention.
Goranov
V A
VA
Institute of Physiology, Belorussia Academy of Sciences, Minsk.
Murzënok
P P
PP
D015551:Autoimmunity / Q000276:immunology / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000503:physiopathology*; D015213:Neuroimmunomodulation / Q000276:immunology / Q000502:physiology; D009490:Neurosecretory Systems / Q000276:immunology / Q000503:physiopathology*; D010179:Pancreas / Q000276:immunology / Q000503:physiopathology*
Lokal'naia immunoneĭroéndokrinnaia sistema podzheludochnoĭ zhelezy i razvitie sakharnogo diabeta I tipa. Gipoteza.