Duodenal gastric metaplasia, gastric anatomic-functional correlations (parietal cell mass and hydrochloric acid secretion) and Helicobacter pylori. Any differences between chronic autonomous non-specific duodenitis ("non active") and duodenal ulcer?
METHODS
Aim of the present experience was to carry out a study on a dyspeptic population in order to verify the role of Helicobacter Pylori (HP), duodenal gastric metaplasia (GM), hydrochloric acid secretion in the genesis of chronic autonomous non-specific duodenitis (ANSD). A comparison with duodenal ulcer (DU) was effected.


RESULTS
Histology showed the presence of ANSD in 24.6% of dyspeptic population. GM was present in 15.1% of ANSD, in 12.8% of dyspepsia without ANSD and in 78.1% of DU. HP in duodenum was present in 12.1% of ANSD, in 10.8% of cases of dyspepsia and in 75% of DU. Concerning parietal cell mass and acid secretion in ANSD and in dyspepsia was found a prevalence of normoparietalism with normochlorhydria, while in DU was found a prevalence of hyperparietalism with hyperchlorhydria. This study shows that the role of HP has not a well defined etiologic weight in ANSD.


CONCLUSIONS
The observations of the present experience, which differentiate ANSD and DU, lead to exclude a pathogenetic relation between ANSD and DU.
Testino
G
G
Department of Gastroenterology and Digestive Endoscopy, San Martino Hospital, Genova, Italy.
Cornaggia
M
M
Cheli
R
R
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004378:Duodenal Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004381:Duodenal Ulcer / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D004382:Duodenitis / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D004386:Duodenum / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D006851:Hydrochloric Acid / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000473:pathology; D013270:Stomach / Q000033:anatomy & histology* / Q000382:microbiology / Q000502:physiology*
D006851:Hydrochloric Acid