[Drug sensitivity of falciparum malaria imported into France in 1995].
The National Reference Centre for Malaria Chemosusceptibility (CNRCP) and the Tropical Medicine Institute of the Health Department for the Army (IMTSSA) monitor the chemosusceptibility of falciparum malaria introduced in France. In 1995, 353 isolates of P. falciparum are sent to the CNRCP and IMTSSA from malaria cases presenting in 49 civil and military hospitals distributed all over the french country. The patients are mostly Africans living in France and have mainly stayed in West Africa. Half of them did not take any chemoprophylaxis and a quarter took only chloroquine more or less regularly. The curative treatment, when known, is halofantrine alone in 52% of cases and quinine alone in 28% of cases. Three halofantrine failures are reported including 1 incorrect regimen and 4 quinine failures including 3 incorrect regimens. In 1995, in vitro resistance of P. falciparum isolates imported in France to the chemoprophylactic and therapeutic drugs is not worsening. In vitro quinine resistance is rare (1/108), mefloquine resistance (2/20) and halofantrine resistance (12/211) are limited, cycloguanil resistance (42/185) is stable and chloroquine resistance (84/230) is even decreasing (less selective pressure in Africa?).
Longuet
C
C
Centre national de référence de la chimiosensibilité du paludisme, hôpital Bichat-Claude Bernard, Paris.
Ramiliarisoa
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O
Thor
R
R
Bouchaud
O
O
Basco
L K
LK
Doury
J C
JC
Le Bras
J
J
D000293:Adolescent; D000328:Adult; D000354:Africa, Western / Q000208:ethnology; D000368:Aged; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D004641:Emigration and Immigration; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000208:ethnology* / Q000469:parasitology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011159:Population Surveillance; D012111:Residence Characteristics
D000962:Antimalarials
Chimiosensibilité du paludisme d'importation à Plasmodium falciparum en France en 1995.