title: Erythromycin gastrokinetic activity is partially vagally mediated.
abstract: Erythromycin overcomes postvagotomy gastroparesia in patients without a distal stomach and functional pylorus. We investigate the role of the vagus in gastric emptying increased by erythromycin, using a model that preserves the physiology of the distal stomach and pylorus. The effects of erythromycin lactobionate (10 mg/kg) on transpyloric flow pattern and pyloric resistance were evaluated during repetitive bilateral vagal cooling in anesthetized pigs. Vagal cooling during erythromycin infusion produced a marked decreased of pyloric outflow (23 +/- 1.1 vs 50 +/- 2.6 ml/min) related to a reduced stroke volume of the flow pulses (7.8 +/- 3.31 vs. 14.1 +/- 2.44 ml). The amplitude and frequency of gastric and duodenal pressure events were unchanged or slightly reduced during vagal cooling. The smaller stroke volume of flow pulse was the consequence of increased pyloric resistance (6.2 +/- 1.98 vs. 2.3 +/- 0.21 mmHg.ml-1.s), which is associated with changes in the temporal relationship between a pyloric pressure event and flow pulse. In conclusion, erythromycin activity on the pylorus requires the integrity of vagal pathways. Enhancement of gastric outflow by erythromycin is also modulated by the vagus, since pyloric resistance was able to overcome increased gastric motility.
authors.affiliation: Unité de Contrôle des Flux Digestifs et Métabolisme Protéique, Institut National de la Recherche Agronomique, Saint-Gilles, France.
authors.forename: C
authors.initials: C
authors.lastname: Mathis
authors.forename: C H
authors.initials: CH
authors.lastname: Malbert
mesh_terms: D000818:Animals; D004386:Duodenum / Q000187:drug effects / Q000502:physiology*; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D007262:Infusions, Intravenous; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D011706:Pyloric Antrum; D013270:Stomach / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D013552:Swine; D013997:Time Factors; D014628:Vagotomy; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
chemical_list: C010948:erythromycin lactobionate; D004917:Erythromycin