title: Relation of coagulation parameters to patency and recurrent ischemia in the Thrombolysis in Myocardial Infarction (TIMI) Phase II Trial.
abstract: Current protocols for use of tissue-type plasminogen activator in acute myocardial infarction include heparin estimated by the activated partial thromboplastin time (aPTT). Recent reports indicate a risk of recurrent ischemic events with long aPTT values. Longer aPTT values in the Thrombolysis in Myocardial Infarction-II (TIMI II) Trial, obtained within the first 48 hours, were associated with patency at 18 to 48 hours and better left ventricular function at discharge (average 9.6 days), but also with emergency catheterizations within the first 48 hours and, weakly, with recurrent ischemia during the first 18 hours. A moderate decrease in fibrinogen, compared with a "small" decrease, was also associated with patency, but a "large" decrease was associated with hemorrhagic events. Patency was associated with higher fibrinogen values and higher plasminogen values at baseline. The aPTT results support frequent monitoring during the first 24 to 48 hours to ensure optimal clinical outcome. The coagulation factor results suggest that there may be an optimum window for fibrinogenolysis in this setting.
authors.affiliation: Department of Pathology, University of Vermont College of Medicine, Colchester 05446, USA. rtracy@salus.uvm.edu
authors.forename: R P
authors.initials: RP
authors.lastname: Tracy
authors.forename: N S
authors.initials: NS
authors.lastname: Kleiman
authors.forename: B
authors.initials: B
authors.lastname: Thompson
authors.forename: C P
authors.initials: CP
authors.lastname: Cannon
authors.forename: E G
authors.initials: EG
authors.lastname: Bovill
authors.forename: R G
authors.initials: RG
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Collen
authors.forename: E
authors.initials: E
authors.lastname: Mahan
authors.forename: K G
authors.initials: KG
authors.lastname: Mann
authors.forename: W J
authors.initials: WJ
authors.lastname: Rogers
authors.forename: G
authors.initials: G
authors.lastname: Sopko
authors.forename: D C
authors.initials: DC
authors.lastname: Stump
authors.forename: D O
authors.initials: DO
authors.lastname: Williams
authors.forename: B L
authors.initials: BL
authors.lastname: Zaret
mesh_terms: D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D010314:Partial Thromboplastin Time; D010958:Plasminogen / Q000032:analysis; D012008:Recurrence; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000627:therapeutic use; D014654:Vascular Patency
chemical_list: D005340:Fibrinogen; D010958:Plasminogen; D010959:Tissue Plasminogen Activator