title: HLA-B alleles associated with the B15 serologically defined antigens.
abstract: Cells expressing HLA molecules in the B15 family were identified by serologic typing in routine testing of volunteer donors of various ethnic backgrounds for a bone marrow registry. DNA sequencing was used to identify HLA-B15 alleles associated with each serologic type and to examine the diversity within the B15 antigen family. Alleles which appeared predominantly in each B15 serologic cluster included: B15 with no defined serologic subdivision (B*1501), B62 (B*1501), B63 (B*1516, B*1517), B75 (B*1502, B*1521), and B76/77 (B*1513). Other B*15 alleles were also found associated with the serotypes and some of these alleles (e.g., B*1501 and B*1516) were found in two or more serologic clusters illustrating the complexity of this family. The B15 unsplit and B75 groups were the most complex exhibiting 16 and 7 alleles, respectively, within each serotype. Five new B*15 alleles (B*1530, B*1531, B*1533, B*1534, B*1535) and 5 other new HLA-B alleles (B*38022, B*3910, B*4010, B*51012, and B*5108) were also identified.
authors.affiliation: Department of Microbiology and Immunology, Georgetown University Medical School, Washington, DC 20007, USA.
authors.forename: N
authors.initials: N
authors.lastname: Steiner
authors.forename: J
authors.initials: J
authors.lastname: Ng
authors.forename: J
authors.initials: J
authors.lastname: Bush
authors.forename: R J
authors.initials: RJ
authors.lastname: Hartzman
authors.forename: L
authors.initials: L
authors.lastname: Johnston-Dow
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
mesh_terms: D000483:Alleles; D000940:Antigenic Variation; D003429:Cross Reactions; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D017422:Sequence Analysis, DNA; D012698:Serologic Tests
chemical_list: D015235:HLA-B Antigens