[The correction of amphetamine action by the delta sleep-inducing peptide].
Effects of "delta-sleep inducing peptide" administration (60 micrograms/kg) to rats on the background of amphetamine action (2.5 mg/kg during 3 weeks) were studied. Activities of the enzymes of neurotransmitter turnover as well as the contents of biogenic amines in structures of motor cortex and caudate nucleus were investigated. Normalizing action of the peptide on the studied indices was found. It reflected the correction of the increased activity of dopaminergic and serotoninergic systems elevated as a result of amphetamine action. The suggestion was made that reconstruction of the interactions of neurotransmitter systems in brain providing adaptive behavior in animals was the main mechanism of delta-sleep inducing peptide's action.
Dovedova
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EL
Monakov
M Iu
MIu
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009044:Motor Cortex / Q000187:drug effects / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001679:Biogenic Amines; D018765:Dopamine Uptake Inhibitors; D018377:Neurotransmitter Agents; D003701:Delta Sleep-Inducing Peptide; D000661:Amphetamine
Korrektsiia deĭstviia amfetamina peptidom, indutsiruiushchim del'ta-son.