title: Increased levels of the soluble adhesion molecule E-selectin in patients with chronic myeloproliferative disorders and thromboembolic complications.
abstract: Patients with chronic myeloproliferative disorders (CMD) show a high frequency of thrombosis. For this reason we evaluated endothelial cell markers, soluble adhesion molecule E-selectin (sELAM), and thrombomodulin (TM) in 25 patients with CMD. Among them nine presented thromboses in their past history. Data were compared with those obtained in a group of healthy subjects and a group of patients with secondary thrombocytosis. The mean plasma concentrations of sELAM were elevated in patients with CMD, as compared with healthy subjects (81.27 +/- 42.8 ng/ml vs. 41.75 +/- 13; P < 0.02). Similarly, the mean plasma concentrations of sTM were increased in CMD patients in comparison with the control group (102.0 +/- 73 ng/ml vs. 16.7 +/- 9.6; P < 0.01). More markedly elevated sELAM levels were observed in CMD patients with thrombosis than in patients without thrombosis (113.16 +/- 29.5 ng/ml vs. 55.11 +/- 19.1 ng/ml; P < 0.001), while no significant difference was found between CMD patients without thrombosis and secondary thrombocytosis (50.72 +/- 10.8 ng/ml). Plasma thrombomodulin values in CMD patients with thrombosis (131 +/- 93.8 ng/ml) were higher than those without thrombosis (65.77 +/- 43.9 ng/ml; P < 0.02). sTM values were also significantly increased in patients with secondary thrombocytosis (P < 0.01). It is speculated that the plasma, sELAM levels may reflect endothelium activation and that it is possibly useful in predicting the thrombotic risk in myeloproliferative disorders.
authors.affiliation: Department of Internal Medicine, Università di Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Musolino
authors.forename: A
authors.initials: A
authors.lastname: Alonci
authors.forename: A
authors.initials: A
authors.lastname: Allegra
authors.forename: G
authors.initials: G
authors.lastname: Spatari
authors.forename: G
authors.initials: G
authors.lastname: Bellomo
authors.forename: O
authors.initials: O
authors.lastname: Tringali
authors.forename: C
authors.initials: C
authors.lastname: Quartarone
authors.forename: G
authors.initials: G
authors.lastname: Squadrito
authors.forename: M
authors.initials: M
authors.lastname: Quartarone
mesh_terms: D000328:Adult; D015415:Biomarkers; D002908:Chronic Disease; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000097:blood* / Q000150:complications; D013923:Thromboembolism / Q000097:blood* / Q000209:etiology; D018180:Thrombomodulin / Q000097:blood*
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D018180:Thrombomodulin