[Mechanism of phototoxicity induced by drugs].
First of all some general concepts are given on phototoxic activity of pharmaceutical products which full fill the structural characteristics required to decompose by light and to cause biological damage, either themselves, their photoproducts or the products of their metabolism. These considerations are important due to the fact that this field of research is fairly new. Next, a review is given on recent research carried out in this laboratory on the photochemistry and phototoxicity of fibric acid and their derivatives and finally a review is made as well on the photochemistry and phototoxicity of antibacterial quinolones. Mechanisms are postulated for the photochemical decomposition of the substances investigated and possible mechanism for the in vitro activity at cellular level are also presented.
Vargas
F
F
Centro de Química, Instituto Venezolano de Investigaciones Científicas I.V.I.C., Caracas, Venezuela.
Rivas
C
C
Canudas
N
N
Torrealba
A
A
Sarabia
Z
Z
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000633:toxicity; D002087:Butyrates / Q000633:toxicity; D017484:Dermatitis, Phototoxic / Q000378:metabolism*; D064420:Drug-Related Side Effects and Adverse Reactions; D011345:Fenofibrate / Q000633:toxicity; D015248:Gemfibrozil / Q000633:toxicity; D000960:Hypolipidemic Agents / Q000633:toxicity; D010777:Photochemistry; D010782:Photolysis
D042462:4-Quinolones; D000890:Anti-Infective Agents; D002087:Butyrates; D000960:Hypolipidemic Agents; D015248:Gemfibrozil; D011345:Fenofibrate
Elucidación de los mecanismos de fototoxicidad inducida por fármacos.