The mouse trap.
Mouse models of asthma are now being used extensively in drug research. However, the successful unravelling of combinatorial interplays of cells and molecules in the murine airways may not be matched by equally successful demonstrations of an asthma-like pathophysiology. Here, Carl Persson, Jonas Erjefält, Magnus Korsgren and Frank Sundler discuss the fact that major features of asthma may still need to be demonstrated in the airways of allergic mice.
Persson
C G
CG
Department of Clinical Pharmacology, University Hospital of Lund, Sweden.
Erjefält
J S
JS
Korsgren
M
M
Sundler
F
F
D000485:Allergens / Q000633:toxicity; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D016535:Bronchial Hyperreactivity / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D002199:Capillary Permeability; D015550:Cell Degranulation; D004195:Disease Models, Animal; D004804:Eosinophils / Q000502:physiology*; D004847:Epithelial Cells / Q000276:immunology; D008168:Lung / Q000276:immunology*; D051379:Mice; D009092:Mucous Membrane / Q000276:immunology; D010641:Phenotype
D000485:Allergens