Labeling and biodistribution studies of Tc-99m radiopharmaceuticals with (o-hydroxyphenyl)diphenylphosphine.
New Tc-99m radiopharmaceuticals with the ligand (o-hydroxyphenyl)diphenylphosphine have been prepared and their biodistributions evaluated in rats. The monoxo Tc(V) complex [99mTc(O)Cl(PO)2], the Tc(IV) complex [99mTc(OH)2(PO)2], the Tc(III) complex [99mTc(PO)3], and the nitrido Tc(V) complex [99mTc(N)(PO)2] have been characterized by TLC and HPLC chromatography, and their chemical structure elucidated by comparison with the corresponding complexes obtained using the beta-emitting isotope Tc-99g. Biodistribution studies of these complexes have been carried out in rats.
Bolzati
C
C
Department of Clinical and Experimental Medicine, University of Ferrara, Italy.
Uccelli
L
L
Refosco
F
F
Tisato
F
F
Duatti
A
A
Giganti
M
M
Piffanelli
A
A
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007553:Isotope Labeling / Q000379:methods; D010636:Phenols / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017556:Technetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
C111013:(2-hydroxyphenyl)diphenylphosphine; D010636:Phenols; D010720:Phosphines; D019275:Radiopharmaceuticals; D017556:Technetium Compounds