title: Heterobifunctional membranes by plasma induced graft polymerization as an artificial organ for penetration keratoprosthesis.
abstract: Highly biocompatible polymer membrane was developed for an artificial cornea in this surface modification study. Heterobifunctional silicone rubber membranes (hetero-SR) were prepared by grafting different functional polymers on each side of a silicone rubber membrane (SR). A novel type of bifunctional membrane was developed with the upper-side favoring cell attachment and growth, and the lower-side suppressing cell adhesion. The preparation of heterobifunctional membranes, characterization of polymer membrane surface properties such as ATR-FTIR and ESCA and contact angle, and biological analysis (in vitro and in vivo studies) were investigated in this work. Based on the biological analysis, the heterobifunctional membrane displays promising potential for use as an artificial cornea.
authors.affiliation: Department of Ophthalmology, Taichung Veterans General Hospital, Taiwan, ROC.
authors.forename: P C
authors.initials: PC
authors.lastname: Chang
authors.forename: S D
authors.initials: SD
authors.lastname: Lee
authors.forename: G H
authors.initials: GH
authors.lastname: Hsiue
mesh_terms: D000327:Adsorption; D000818:Animals; D001187:Artificial Organs; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D003094:Collagen / Q000737:chemistry / Q000494:pharmacology; D003315:Cornea / Q000502:physiology*; D016039:Corneal Transplantation / Q000379:methods*; D005455:Fluorescent Antibody Technique; D006801:Humans; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D010973:Platelet Adhesiveness / Q000187:drug effects; D011506:Proteins / Q000737:chemistry; D011817:Rabbits; D012826:Silicone Elastomers; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011506:Proteins; D012826:Silicone Elastomers; D003094:Collagen