title: Comparative linkage mapping of genes on sheep chromosome 3 provides evidence of chromosomal rearrangements in the evolution of the Bovidae.
abstract: Three genes--parathyroid hormone-like hormone (PTHLH), insulin-like growth factor 1 (IGF 1), and retinoic acid receptor gamma (RARG)--have been mapped to sheep (Ovis aries) chromosome 3 (OAR 3). The order and genetic distances between loci on OAR 3 are similar to those on cattle (Bos taurus) chromosome 5, as expected from their close evolutionary relationship. The OAR 3 linkage map shows conserved synteny with human chromosome 12, but there are at least two rearrangements in gene order between the species.
authors.affiliation: Department of Biochemistry, University of Otago, Dunedin, New Zealand. jenkinsz@agresearch.cri.nz
authors.forename: Z A
authors.initials: ZA
authors.lastname: Jenkins
authors.forename: H M
authors.initials: HM
authors.lastname: Henry
authors.forename: S M
authors.initials: SM
authors.lastname: Galloway
authors.forename: K G
authors.initials: KG
authors.lastname: Dodds
authors.forename: G W
authors.initials: GW
authors.lastname: Montgomery
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D019143:Evolution, Molecular; D015321:Gene Rearrangement; D008040:Genetic Linkage; D018859:Hair Follicle; D010281:Parathyroid Hormone / Q000235:genetics; D044162:Parathyroid Hormone-Related Protein; D012150:Polymorphism, Restriction Fragment Length; D011506:Proteins / Q000235:genetics; D018168:Receptors, Retinoic Acid / Q000235:genetics; D012756:Sheep / Q000235:genetics*; D013045:Species Specificity; D014935:Wool; D000097768:Retinoic Acid Receptor gamma
chemical_list: D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D018168:Receptors, Retinoic Acid; D000097768:Retinoic Acid Receptor gamma