title: A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyltransferase.
authors.affiliation: Drug Discovery Research Laboratory, Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd., Japan.
authors.forename: T
authors.initials: T
authors.lastname: Aoyama
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Yonemoto
authors.forename: J
authors.initials: J
authors.lastname: Shibata
authors.forename: K
authors.initials: K
authors.lastname: Nonoshita
authors.forename: S
authors.initials: S
authors.lastname: Arai
authors.forename: K
authors.initials: K
authors.lastname: Kawakami
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasawa
authors.forename: H
authors.initials: H
authors.lastname: Sano
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Monden
authors.forename: T
authors.initials: T
authors.lastname: Kodera
authors.forename: H
authors.initials: H
authors.lastname: Arakawa
authors.forename: I
authors.initials: I
authors.lastname: Suzuki-Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Kamei
authors.forename: K
authors.initials: K
authors.lastname: Tomimoto
mesh_terms: D016475:3T3 Cells; D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D051231:Farnesyltranstransferase; D005260:Female; D051379:Mice; D008819:Mice, Nude; D008956:Models, Chemical; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011106:Polyisoprenyl Phosphates / Q000737:chemistry* / Q000494:pharmacology; D012717:Sesquiterpenes; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011106:Polyisoprenyl Phosphates; D012717:Sesquiterpenes; C004808:farnesyl pyrophosphate; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase