title: [The reaction of 3-(R-phenyl)-6-hydrazine pyridazine with 5-methylisatin and 1-morpholinomethyl-5-methylisatin].
abstract: This paper presents the synthesis of six hydrazones obtained by treating 5-methyl-isatin or 1-morpholino methyl-5-methyl-isatin with 3-(R-phenyl)-6-hydrazino-pyridazine (R = OCH3, Cl, Br) and two complex combination with copper, derived from 3-(p-anisyl-pyridazinyl)-hydrazone-5-methyl-indoline-2- one. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR, UV-VIS spectral analysis. The biological tests point out that product VI, in which a copper atom binds two molecules of 3-(p-anisyl-pyridazinyl)-hydrazono-5-methyl-indoline-2-one, has a considerable antiinflammatory activity, giving a inflammation inhibition of 39, 6%. All the synthetized compounds have a moderate antimicrobial activity against Candida albicans.
authors.affiliation: Faculté de Pharmacie, Université de Médecine et de Pharmacie Gr. T. Popa, Iaşi.
authors.forename: M
authors.initials: M
authors.lastname: Dorneanu
authors.forename: E
authors.initials: E
authors.lastname: Stefănescu
authors.forename: O
authors.initials: O
authors.lastname: Păduraru
authors.forename: M
authors.initials: M
authors.lastname: Pavelescu
authors.forename: A
authors.initials: A
authors.lastname: Hriscu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D002351:Carrageenan; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects; D006834:Hydrazines / Q000737:chemistry*; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007510:Isatin / Q000031:analogs & derivatives* / Q000737:chemistry; D051379:Mice; D011724:Pyridazines / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: C110649:1-morpholinomethyl-5-methylisatin; C110647:3-phenyl-6-hydrazinopyridazine; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D006834:Hydrazines; D006835:Hydrazones; D011724:Pyridazines; C110648:5-methylisatin; D007510:Isatin; D002351:Carrageenan
vernacular_title: La réaction de la 3-(R-phényle)-6-hydrazino-pyridazine avec la 5-méthyl-isatine et la 1-morpholinométhyl-5-méthyl-isatine.