title: Pressure support ventilation in adult respiratory distress syndrome: short-term effects of a servocontrolled mode.
abstract: OBJECTIVE
  To assess the short-term effects of pressure support ventilation in adult respiratory distress syndrome (ARDS), we studied 17 patients with moderate to severe ARDS using mandatory rate ventilation (MRV), a servocontrolled mode of PSV having respiratory rate as the targeted parameter.
  
  
  METHODS
  Based on the duration of ARDS, the patients were divided into two groups: Group 1, early ARDS (duration up to 1 week), 10 patients; Group 2, intermediate ARDS (duration between 1 and 2 weeks). The patients were initially ventilated with assisted mechanical ventilation then with MRV, and finally with controlled mechanical ventilation. After a 20-minute period allowed for stabilization in each mode, ventilatory variables, gas exchange, hemodynamics, and patient's inspiratory effort were evaluated.
  
  
  RESULTS
  During MRV blood gases, airway pressures and hemodynamic variables remained within acceptable limits in all patients. Compared with assisted mechanical ventilation, during MRV, patients of group 1 decreased their VT and V (from 0.64 +/- 0.04 to 0.42 +/- 0.03 L/sec) and increased their TI/TT (from 0.39 +/- 0.03 to 0.52 +/- 0.03). f did not change. PAO2 - PaO2 and QS/QT decreased (from 306 +/- 16 to 269 +/- 15 mm Hg, and from 20.2 +/- 1.4 to 17.5 +/- 1.1, respectively), while PaCO2 increased (from 44 +/- 3 to 50 +/- 3 mm Hg). On the contrary, patients of group 2 increased their VT (from 0.69 +/- 0.02 to 0.92 +/- 0.09 L), decreased their f (from 22.3 +/- 0.5 to 19.3 +/- 0.3 b/min), although they did not change their V and TI/TT. PAO2 - PaO2 and QS/QT remained stable. PaCO2 diminished (from 39 +/- 3 to 34 +/- 3 mm Hg). Pressure support level was higher in group 2 than in group 1 (29.4 +/- 3.0 v 19.8 +/- 2.9 cm H2O).
  
  
  CONCLUSIONS
  We conclude that (1) PSV delivered by MRV may adequately ventilate patients with moderate to severe ARDS, preserving gas exchange and hemodynamics, at least for the short period tested; (2) early and intermediate ARDS respond in a different manner to MRV in terms of breathing pattern, gas exchange, and level of pressure assistance; and (3) patients with early ARDS are those who have an improvement in intrapulmonary oxygenation probably due, at least in part, to alveolar recruitment augmented by active diaphragmatic contraction.
authors.affiliation: Department of Critical Care and Pulmonary Services, Athens University Medical School, Evangelismos Hospital, Greece.
authors.forename: S G
authors.initials: SG
authors.lastname: Zakynthinos
authors.forename: T
authors.initials: T
authors.lastname: Vassilakopoulos
authors.forename: Z
authors.initials: Z
authors.lastname: Daniil
authors.forename: E
authors.initials: E
authors.lastname: Zakynthinos
authors.forename: E
authors.initials: E
authors.lastname: Koutsoukos
authors.forename: K
authors.initials: K
authors.lastname: Katsouyianni
authors.forename: C
authors.initials: C
authors.lastname: Roussos
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007320:Inspiratory Capacity; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D011175:Positive-Pressure Respiration / Q000379:methods*; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation; D012128:Respiratory Distress Syndrome / Q000503:physiopathology* / Q000628:therapy*; D012720:Severity of Illness Index; D012122:Ventilators, Mechanical