title: Efficacy of amlodipine in pediatric bone marrow transplant patients.
abstract: The calcium antagonist amlodipine may have the potential for expanded use in children owing to its physiochemistry and pharmacokinetic profile that facilitates once-daily dosing in a liquid formulation. Its safety and efficacy have not been previously evaluated in children. A retrospective analysis of 15 pediatric bone marrow transplant patients who had amlodipine incorporated into their antihypertensive drug regimen reveals significantly lower blood pressure as compared with baseline therapy (123.5+/-2.1 mmHg and 117.2+/-2.2 mmHg, systolic blood pressure before and during amlodipine, P<0.05; 81.5+/-1.8 mmHg and 75.5+/-2.6 mmHg, diastolic blood pressure before and during amlodipine, P<0.05). Amlodipine provided improved blood pressure control in this cohort and may provide a valuable pharmacologic alternative for treatment of pediatric hypertension.
authors.affiliation: Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, The University of Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Khattak
authors.forename: J W
authors.initials: JW
authors.lastname: Rogan
authors.forename: E F
authors.initials: EF
authors.lastname: Saunders
authors.forename: J G
authors.initials: JG
authors.lastname: Theis
authors.forename: G S
authors.initials: GS
authors.lastname: Arbus
authors.forename: G
authors.initials: G
authors.lastname: Koren
mesh_terms: D000293:Adolescent; D000367:Age Factors; D017311:Amlodipine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007223:Infant; D007668:Kidney / Q000187:drug effects; D008297:Male; D011182:Postoperative Care
chemical_list: D017311:Amlodipine