Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5.
The mitogen-activated protein kinase (MAPK) signaling cascade is one of the most important mechanisms for the cytoplasmic transduction of extracellular signals. We report the chromosomal localization of the human MEK1, MEK3, MEK4 and MEKK5 genes, involved in the MAPK cascade. Using radiation hybrid mapping, MEK1 was assigned to chromosome 15q22.1 --> q22.33, MEK3 to chromosome 17q11.2, MEK4 to chromosome 17p12, and MEKK5 to chromosome 6q22.33.
Rampoldi
L
L
Biology Department, University of Padova, Italy.
Zimbello
R
R
Bortoluzzi
S
S
Tiso
N
N
Valle
G
G
Lanfranchi
G
G
Danieli
G A
GA
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics*; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002896:Chromosomes, Human, Pair 6; D006224:Cricetinae; D017931:DNA Primers; D006801:Humans; D006822:Hybrid Cells; D048369:MAP Kinase Kinase 1; D048671:MAP Kinase Kinase 5; D020929:Mitogen-Activated Protein Kinase Kinases; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011828:Radiation Chimera; D015398:Signal Transduction / Q000235:genetics
D017931:DNA Primers; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D048369:MAP Kinase Kinase 1; D048671:MAP Kinase Kinase 5; C482125:MAP2K1 protein, human; C482563:MAP2K5 protein, human; D020929:Mitogen-Activated Protein Kinase Kinases