Mammalian artificial chromosomes--vectors for somatic gene therapy.
Mammalian artificial chromosomes might prove to be useful vectors for somatic gene therapy. The functional elements of such an artificial chromosome are telomeres, a centromere and a replication origin. Recent progress in the characterization of these functional elements of the eukaryotic chromosome will be described. Attempts to construct artificial chromosomes for mammalian cells and their use for somatic gene therapy are discussed.
Ascenzioni
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Instituto Pasteur, Fondazione Cenci Bolognetti, Dipartimento di Biologia cellulare e dello Sviluppo, University of Rome, Italy.
Donini
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Lipps
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D000818:Animals; D002503:Centromere; D002875:Chromosomes; D004261:DNA Replication; D004270:DNA, Circular; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D008322:Mammals; D018741:Replication Origin; D019098:Telomerase; D016615:Telomere
D004270:DNA, Circular; D019098:Telomerase