Respiratory syncytial virus pneumonitis-induced diffuse alveolar damage in an autologous bone marrow transplant recipient.
A 24-year-old woman with recurrent Hodgkin's lymphoma, stage IIB nodular sclerosing type, underwent an autologous bone marrow transplantation. Forty-five days after transplantation, an upper respiratory tract infection developed that progressed to respiratory distress necessitating mechanical ventilation. An open-lung biopsy demonstrated diffuse alveolar damage. After an extensive search for the cause of the respiratory compromise, we detected respiratory syncytial virus in a bronchoalveolar lavage specimen. The patient was immediately treated with aerosolized ribavirin and intravenous immunoglobulin; her symptoms resolved, and she was extubated 4 days after initiation of therapy.
Markovic
S N
SN
Department of Internal Medicine, Mayo Clinic Rochester, Minnesota 55905, USA.
Adlakha
A
A
Smith
T F
TF
Walker
R C
RC
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D011014:Pneumonia / Q000150:complications* / Q000628:therapy / Q000821:virology*; D011650:Pulmonary Alveoli / Q000821:virology*; D018357:Respiratory Syncytial Virus Infections / Q000150:complications* / Q000628:therapy; D012254:Ribavirin / Q000627:therapeutic use; D014182:Transplantation, Autologous
D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D012254:Ribavirin