Molecular physiology of cardiac delayed rectifier K+ channels.
Delayed rectifier K+ current in cardiac myocytes is the sum of two distinct currents, IKr and IKs. The molecular basis of these channels has recently been defined. HERG subunits coassemble to form IKr channels. KvLQT1 and minK subunits coassemble to form IKs channels. Mutations in HERG or KVLQT1 genes predispose affected individuals to ventricular arrhythmias and sudden death.
Sanguinetti
M C
MC
University of Utah, Department of Medicine, Salt Lake City 84112, USA.
Zou
A
A
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000235:genetics*; D016757:Death, Sudden, Cardiac; D006321:Heart / Q000502:physiology*; D006801:Humans; D015640:Ion Channel Gating / Q000235:genetics; D008133:Long QT Syndrome / Q000235:genetics; D015221:Potassium Channels / Q000235:genetics*
D015221:Potassium Channels