title: Radiation-induced double-strand modification in calf thymus DNA in the presence of 1,2-dihydroxy-9,10-anthraquinone and its Cu(II) complex.
abstract: When cells or DNA is exposed to ionizing radiation, the radicals produced in the irradiated sample will modify the base-pair region of the double strands. Effects of 1,2-dihydroxy-9,10-anthraquinone (DHA) and its Cu(II) complex on the radiation-induced modification of double-strands in calf thymus DNA were studied using ethidium bromide as a fluorescent probe. Our results show that the Cu(II)-DHA complex is more efficient in modifying the base-pair region in double-stranded DNA compared to free DHA.
authors.affiliation: Nuclear Chemistry Division, Saha Institute of Nuclear Physics, Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Das
authors.forename: A
authors.initials: A
authors.lastname: Saha
authors.forename: P C
authors.initials: PC
authors.lastname: Mandal
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D002417:Cattle; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage / Q000187:drug effects*; D007502:Iron Chelating Agents / Q000633:toxicity*; D009154:Mutation
chemical_list: D000880:Anthraquinones; D007502:Iron Chelating Agents; C010078:alizarin; D004247:DNA