title: Calcitonin gene-related peptide (CGRP) and hypertrophy of cardiomyocytes.
abstract: We studied whether calcitonin gene-related peptide (CGRP), a neuropeptide secreted from the sensory nervous supply to the myocardium, induces hypertrophy of cardiomyocytes in culture. CGRP increased the cell surface area of neonatal rat cardiomyocytes; the surface area of the cells was almost doubled by treatment with CGRP for 48 h. Furthermore, CGRP up-regulated mRNA expression for skeletal alpha-actin and atrial natriuretic peptides, which are genetic markers for cardiac hypertrophy. These results indicate that CGRP is a potent hypertrophic factor for cardiomyocytes.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: D
authors.initials: D
authors.lastname: Bell
authors.forename: M
authors.initials: M
authors.lastname: Tamamori
authors.forename: T
authors.initials: T
authors.lastname: Nozato
authors.forename: T
authors.initials: T
authors.lastname: Shimojo
authors.forename: S
authors.initials: S
authors.lastname: Adachi
authors.forename: S
authors.initials: S
authors.lastname: Abe
authors.forename: F
authors.initials: F
authors.lastname: Marumo
authors.forename: M
authors.initials: M
authors.lastname: Hiroe
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D006332:Cardiomegaly / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D006801:Humans; D017379:Hypertrophy, Left Ventricular; D009206:Myocardium / Q000166:cytology* / Q000473:pathology; D051381:Rats
chemical_list: D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D015740:Calcitonin Gene-Related Peptide