title: Diabetes microvascular complications in prepubertal children.
abstract: These are the baseline findings of a group of 68 prepubertal children enrolled in a longitudinal study of the development of early diabetes microvascular complications prior to gonadarche. The median age of the children was 9.8 years, the median diabetes duration 3.6 years and the mean HbA1c 8.4%. Mild nonproliferative retinopathy was present in 6 of 67 (9%) children, assessed by 7-field stereoscopic fundus photography. Those with retinopathy had higher total cholesterol (p < 0.05) and lower DHEAS (p < 0.01). Albumin excretion rate (AER) was calculated as the mean of three overnight consecutive urine collections. AER > 7.5 micrograms/min was present in 5 of 64 (8%), and one boy had a mean AER > 15 micrograms/min. Those with AER > 7.5 micrograms/min had higher diastolic blood pressure and diastolic blood pressure percentiles (p < 0.05). Longitudinal study of this cohort will establish which factors in the prepubertal years are important for the development of diabetes microvascular complications.
authors.affiliation: Ray Williams Institute of Paediatric Endocrinology, Diabetes and Metabolism, Royal Alexandra Hospital for Children, Westmead, NSW, Australia.
authors.forename: K C
authors.initials: KC
authors.lastname: Donaghue
authors.forename: J M
authors.initials: JM
authors.lastname: Fairchild
authors.forename: A
authors.initials: A
authors.lastname: Chan
authors.forename: S J
authors.initials: SJ
authors.lastname: Hing
authors.forename: J
authors.initials: J
authors.lastname: King
authors.forename: N J
authors.initials: NJ
authors.lastname: Howard
authors.forename: M
authors.initials: M
authors.lastname: Silink
mesh_terms: D000419:Albuminuria / Q000652:urine*; D001794:Blood Pressure / Q000502:physiology; D002648:Child; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000503:physiopathology / Q000517:prevention & control / Q000652:urine*; D003930:Diabetic Retinopathy / Q000097:blood* / Q000503:physiopathology / Q000517:prevention & control; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies
chemical_list: D002784:Cholesterol; D019314:Dehydroepiandrosterone Sulfate; D006442:Glycated Hemoglobin