[The receptor and pathways for human cytomegalovirus entry].
The cellular receptor for human cytomegalovirus(HCMV) entry has not been identified. To date, heparan sulfate proteoglycan, annexin II, and CD13(aminopeptidase N) are reported to be associated with HCMV entry into human fibroblast cells. A recombinant HCMV that can express a marker protein on the infected cell was generated and used to assess relationship between HCMV entry and expression of heparan sulfate and CD13. The recombinant virus could infect to two human neuroblastoma-derived cell lines that do not express CD13 but do heparan sulfate on the surface. In addition, a human malignant melanoma-derived cell line that expresses CD13 did not allow HCMV entry. HCMV appears to enter into neuroectodermal tissue-derived cells via a CD13-independent pathway.
Watanabe
S
S
Department of Virology, University of Tokyo.
D000818:Animals; D017306:Annexin A2 / Q000378:metabolism; D018826:CD13 Antigens / Q000378:metabolism; D002478:Cells, Cultured / Q000821:virology; D003587:Cytomegalovirus / Q000472:pathogenicity; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D006801:Humans; D011991:Receptors, Virus / Q000378:metabolism
D017306:Annexin A2; D019812:Heparan Sulfate Proteoglycans; D011991:Receptors, Virus; D018826:CD13 Antigens