title: [Neurological manifestations on collagenoses].
abstract: Collagen diseases are precipitated by very different etiologic factors, but have a common pathogenic mechanism--autoimmune, which evolves chronically and progressively involving new territories. The initial and main pathologic lesions are vascular arterial ischemic (and, according to the prevalently involved territory, the type of disease results: PAN--medium-sized and small arterioles; scleroderma--small arterioles and capillaries), and the secondary ones are the result of ischemia with plurivisceral involvement. Neurological dysfunctions were detected in about 50% of collagen diseases diagnosed during a 25 year interval in the IIIrd Medical Clinic of Iaşi. The neurological manifestations were inaugural in 10% (in SLE) to 46.4% (in PAN) of the cases, the remainder occurring during the course of collagenosis, more commonly at 3-5 years and before death. Peripheral nervous system involvement (mainly polyneuritis) has prevailed, the central nervous system involvement being more rare and often fatal. Long-term corticosteroid therapy was followed by full or partial remission of peripheral nervous dysfunctions, but had transient effects or was ineffective on the central nervous ones.
authors.affiliation: Facultateta de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: V
authors.initials: V
authors.lastname: Ambăruş
authors.forename: A
authors.initials: A
authors.lastname: Cosovanu
authors.forename: G
authors.initials: G
authors.lastname: Ungureanu
authors.forename: R
authors.initials: R
authors.lastname: Grozdan
authors.forename: S
authors.initials: S
authors.lastname: Ionescu
authors.forename: C
authors.initials: C
authors.lastname: Caşcaval
authors.forename: T
authors.initials: T
authors.lastname: Samoil
authors.forename: M
authors.initials: M
authors.lastname: Noghin
authors.forename: C
authors.initials: C
authors.lastname: Rezuş
authors.forename: E
authors.initials: E
authors.lastname: Leuciuc
mesh_terms: D003095:Collagen Diseases / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D009422:Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*
vernacular_title: Manifestări neurologice în colagenoze.