title: Photo-oxidized bovine arterial grafts: short-term results.
abstract: Biologic grafts are the conduit of choice for vascular reconstructive procedures. The short-term thrombogenicity, patency, and stability of bovine arterial grafts, altered by a dye-mediated photo-oxidation process, was evaluated in the canine common femoral vein (CFV) and artery (CFA) model. Modified bovine interposition grafts were implanted in the CFV of 12 dogs and in the CFA of 11 dogs, respectively. Polytetrafluoroethylene (PTFE) implants on the contralateral side served as controls. Patency and histology were assessed at 1, 2, 4, and 6 weeks. In the CFV, patency of photo-oxidized grafts was 83% at 1 week and 71% at 2 weeks, compared to 17% and 0% for PTFE, respectively (p = 0.0033). In CFA, patency was 82% for the photo-oxidized graft and 63% for PTFE at 6 weeks (p = NS). Photo-oxidized grafts were nonreactive, without evidence of degenerative changes or cellular infiltration at all time periods. Compared to commercially available PTFE, photo-oxidized arterial grafts have superior patency in the CFV, and comparable patency in the CFA. Preliminary results demonstrate that these xenografts are stable and without degenerative changes. If corroborated by long-term data, these grafts may be a suitable alternative to currently available prosthetics for peripheral vascular reconstructive procedures.
authors.affiliation: Department of Surgery, Columbia-Presbyterian Medical Center, New York, New York 10032, USA.
authors.forename: N
authors.initials: N
authors.lastname: Moazami
authors.forename: M
authors.initials: M
authors.lastname: Argenziano
authors.forename: M
authors.initials: M
authors.lastname: Williams
authors.forename: S B
authors.initials: SB
authors.lastname: Cabreriza
authors.forename: M C
authors.initials: MC
authors.lastname: Oz
authors.forename: R
authors.initials: R
authors.lastname: Nowygrod
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D004285:Dogs; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D005268:Femoral Vein / Q000000981:diagnostic imaging; D006085:Graft Survival; D010777:Photochemistry; D011138:Polytetrafluoroethylene; D011859:Radiography; D019651:Plastic Surgery Procedures
chemical_list: D001672:Biocompatible Materials; D011138:Polytetrafluoroethylene