Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis: comparison with uninvolved surrounding tissues.
Glutathione (GSH), glutathione S-transferase (GST) activity and GSTpi expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GSTpi expression were higher in tumor tissues (P < 0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GSTpi expression in both tumor and uninvolved tissues.
Hassan
A A
AA
Laboratory of Molecular Toxicology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Tagliabue
G
G
Codegoni
A M
AM
D'Incalci
M
M
el-Sewedy
S M
SM
Airoldi
L
L
D000328:Adult; D002277:Carcinoma / Q000150:complications / Q000201:enzymology / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000378:metabolism; D002295:Carcinoma, Transitional Cell / Q000150:complications / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012552:Schistosomiasis / Q000150:complications; D001743:Urinary Bladder / Q000201:enzymology / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000201:enzymology / Q000378:metabolism*
D007527:Isoenzymes; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D005978:Glutathione