title: Electroretinographic alterations during vitrectomy in human eyes.
abstract: BACKGROUND
  We previously reported a new system of electroretinographic monitoring of the retinal function during vitrectomy in human eyes, and found that lowering the intravitreal temperature by applying an infusion solution kept at room temperature (used routinely for vitrectomy throughout the world) can alter the electroretinogram (ERG). This time we attempted to study the effect upon the ERG of replacing the intraocular medium and acutely elevating the intraocular pressure during vitrectomy.
  
  
  METHODS
  Using a special contact lens with a built-in light-emitting diode light source, 30-Hz flicker ERG was quickly recorded under aseptic conditions.
  
  
  RESULTS
  Acute, reversible reduction in amplitude was observed upon replacing the intraocular medium with air or silicon oil and during periods of acutely elevated intraocular pressure. Infusions of gentamicin or miconazole did not affect the ERG when intravitreal temperature and intraocular pressure were constant.
  
  
  CONCLUSIONS
  The ERG monitor can reveal changes of the retinal function during vitrectomy, particularly when the infusion temperature, intraocular medium and intraocular pressure are kept constant.
authors.affiliation: Department of Ophthalmology, Nagoya University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyake
authors.forename: M
authors.initials: M
authors.lastname: Horiguchi
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001831:Body Temperature; D004596:Electroretinography / Q000187:drug effects; D009877:Endophthalmitis / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure; D008825:Miconazole / Q000008:administration & dosage / Q000627:therapeutic use; D016343:Monitoring, Intraoperative; D019736:Prostheses and Implants; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D012826:Silicone Elastomers; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery
chemical_list: D000935:Antifungal Agents; D012826:Silicone Elastomers; D008825:Miconazole