[Misoprostol--oral prostanoid--the first clinical trial for use in patients with peripheral vascular disease].
Misoprostol, the oral analogue of alprostadil was used for the treatment of 20 patients (aged 40-60) with peripheral arterial disease according to Fontaine's classification at stages IIa and IIb (PAD). All patients received 200 micrograms of misoprostol 3 times a day during a month. The therapy with misoprostol resulted in a clinical improvement in all patients. Elongation of pain free (before treatment 129 m +/- 78 m, after treatment 214 m +/- 109 m) and maximum walking distance (before treatment 304 m +/- 169 m, after treatment 471 m +/- 264 m) was observed. At the same time a shortening of the pain duration was noted (before treatment 100 sec +/- 37 sec, after treatment 71 sec +/- 23 sec). The ankle/arm pressure ratio (AAPR) and arterial blood flow increased in both limbs after 4 weeks of the treatment. Activation of the fibrinolytic system was seen in the course of the therapy (shortening of euglobulin clot lysis time-ECLT and increase in t-PA activity). The platelets became less sensitive to ADP and collagen after intake of misoprostol. The results justify administration of misoprostol as a new therapeutic agent for the treatment of patients with PAD.
Goszcz
A
A
Katedry Farmakologii, Zakładu Farmakologii Klinicznej Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Grodzińska
L
L
Kostka-Trabka
E
E
Bieroń
K
K
Sławiński
M
M
Jachym
R
R
Ochmański
W
W
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001132:Arm / Q000098:blood supply; D005080:Exercise Test; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007866:Leg / Q000098:blood supply; D008875:Middle Aged; D016595:Misoprostol / Q000008:administration & dosage*; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000188:drug therapy*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D012039:Regional Blood Flow / Q000187:drug effects
D010975:Platelet Aggregation Inhibitors; D016595:Misoprostol
Mizoprostol--doustny prostanoid--pierwsza próba klinicznego zastosowania w chorobie niedokrwiennej kończyn dolnych.