title: Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness.
abstract: Three central indices of serotonin (5-HT) system activity in human subjects were examined to: (a) estimate intercorrelations among 5-HT indices and (b) compare correlations of these indices with a measure of assaultiveness (Buss-Durkee 'Assault') in personality-disordered individuals. Cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) concentration and prolactin responses to m-chlorophenylpiperazine (m-CPP) m-CPP (PRL[m-CPP]) and fenfluramine (PRL[FEN]), served as indices of pre-, post- and 'net'-synaptic central 5-HT activity, respectively. PRL[D,L-FEN] responses were inversely related to CSF 5-HIAA concentration and positively correlated with PRL[m-CPP] responses. Both PRL[D,L-FEN] and PRL[m-CPP] response data correlated equally, and inversely, with BD Buss-Durkee Assault when the same subjects were examined. Basal CSF 5-HIAA concentration did not correlate with Buss-Durkee 'Assault'. PRL responses to challenge probes which involve activation of 5-HT post-synaptic receptors may correlate better than a basal measure of pre-synaptic 5-HT function with a tendency to assaultive behavior in non-criminally aggressive personality-disordered individuals.
authors.affiliation: Department of Psychiatry, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA.
authors.forename: E F
authors.initials: EF
authors.lastname: Coccaro
authors.forename: R J
authors.initials: RJ
authors.lastname: Kavoussi
authors.forename: R L
authors.initials: RL
authors.lastname: Trestman
authors.forename: S M
authors.initials: SM
authors.lastname: Gabriel
authors.forename: T B
authors.initials: TB
authors.lastname: Cooper
authors.forename: L J
authors.initials: LJ
authors.lastname: Siever
mesh_terms: D000328:Adult; D000374:Aggression / Q000502:physiology*; D003863:Depression / Q000503:physiopathology; D005260:Female; D005277:Fenfluramine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010554:Personality Disorders / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D010879:Piperazines; D011388:Prolactin / Q000187:drug effects; D012701:Serotonin / Q000134:cerebrospinal fluid / Q000502:physiology*; D018490:Serotonin Agents
chemical_list: D010879:Piperazines; D018490:Serotonin Agents; D005277:Fenfluramine; D012701:Serotonin; D011388:Prolactin; C015068:1-(3-chlorophenyl)piperazine