title: [Genotype and phenotype of apolipoprotein E in patients with Alzheimer's disease in Castille and Leon].
abstract: We determined the variants of the apolipoprotein E (apo-E) in a sample taken from a castellano-leonesa population with Alzheimer's disease (AD). The prevalence of the allele E-4 is 0.33 in AD and 0.12 in the control group. This results allow us to estimate that the risk of suffering from the disease is higher when the patients have an allele E-4. A significant correlation was found between the presence of the allele E4 and the AD (p < 0.005).
authors.affiliation: Servicio de Neurología, Hospital Clínico Universitario, Salamanca.
authors.forename: J
authors.initials: J
authors.lastname: Cacho
authors.forename: T
authors.initials: T
authors.lastname: Breñas
authors.forename: C
authors.initials: C
authors.lastname: González
authors.forename: T
authors.initials: T
authors.lastname: Arroyo
authors.forename: J
authors.initials: J
authors.lastname: Arcaya
authors.forename: R
authors.initials: R
authors.lastname: García
authors.forename: A L
authors.initials: AL
authors.lastname: Guerrero
authors.forename: J A
authors.initials: JA
authors.lastname: Navajo
authors.forename: C
authors.initials: C
authors.lastname: García
authors.forename: J M
authors.initials: JM
authors.lastname: González Buitrago
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics*; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D001057:Apolipoproteins E
vernacular_title: Genotipo y fenotipo de la apolipoproteína E en enfermos de Alzheimer en Castilla y León.