B cell maturation and selection at the marrow-periphery interface.
More than 95% of newly formed B cells die in the short interval spanning sIgM acquisition in the bone marrow and entry into the long-lived pool, suggesting that selective events dictating B cell longevity occur at this stage. These likely include both ligand-induced deletion as well as discrete events that mediate recruitment to the long-lived recirculating pool. We are probing these events through the examination of normal B cell differentiation during this critical period: the characterization of a natural mutation that blocks late maturation, an irradiation/autoreconstitution model of marrow-derived B cell differentiation, and the identification of life span regulatory genes whose expression changes within this window.
Cancro
M P
MP
Dept. of Pathol., Univ. of Penn., Philadelphia 19104, USA. cancro@mail.med.upenn.edu
Allman
D M
DM
Hayes
C E
CE
Lentz
V M
VM
Fields
R G
RG
Sah
A P
AP
Tomayko
M
M
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D009154:Mutation
D007075:Immunoglobulin M