title: Non-invasive measurement of colonic blood flow distribution using laser Doppler imaging.
abstract: BACKGROUND
  This study tested a prototype laser Doppler scanner for the measurement of human colonic blood flow.
  
  
  METHODS
  Blood flow distribution was assessed in human colon during operation in six controls and in six patients with inflammatory bowel disease undergoing colectomy. Image processing software analysed several hundred reading points, expressing average flow in perfusion units.
  
  
  RESULTS
  Blood flow in the colon was not significantly lower in the control group than in patients with inflammatory bowel disease (mean(s.e.m.) 297.8(24.5) versus 347.2(59.0) perfusion units, P = 0.12). Intestinal colonic mural blood supply was demonstrated up to a distance of 6 cm and ischaemia demarcation lines were identified before the onset of visible changes.
  
  
  CONCLUSIONS
  This prototype laser Doppler flowscanner overcomes the previous limitations of laser Doppler flowmeters and may have many clinical and research applications.
authors.affiliation: Department of Coloproctology, Royal Infirmary, University of Strathclyde, Glasgow, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Hajivassiliou
authors.forename: K
authors.initials: K
authors.lastname: Greer
authors.forename: A
authors.initials: A
authors.lastname: Fisher
authors.forename: I G
authors.initials: IG
authors.lastname: Finlay
mesh_terms: D000328:Adult; D000368:Aged; D003106:Colon / Q000098:blood supply*; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D012039:Regional Blood Flow; D018615:Ultrasonography, Doppler, Color / Q000379:methods*