title: Immature teratoma of the pineal gland with isochromosome 12p.
abstract: An immature teratoma arising in the pineal gland in a 27-year-old male was shown to present an isochromosome 12p as evidenced by cytogenetic and fluorescence in situ hybridization analysis. As i(12p) is characteristic of gonadal germ cell tumors, this case indicates that similar genetic pathways may operate in gonadal and intracranial teratomas.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: A P
authors.initials: AP
authors.lastname: Dei Tos
authors.forename: H
authors.initials: H
authors.lastname: Qi
authors.forename: C
authors.initials: C
authors.lastname: Giannini
authors.forename: A
authors.initials: A
authors.lastname: Furlanetto
authors.forename: P L
authors.initials: PL
authors.lastname: Longatti
authors.forename: P
authors.initials: P
authors.lastname: Marynen
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology*; D002881:Chromosomes, Human, Pair 12 / Q000502:physiology / Q000648:ultrastructure; D003582:Cytogenetics; D018237:Germinoma / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D018404:Isochromosomes / Q000502:physiology*; D008297:Male; D008677:Metaphase; D010870:Pineal Gland / Q000473:pathology* / Q000648:ultrastructure; D013724:Teratoma / Q000473:pathology*