The endoplasmic reticulum Ca2+ store: a view from the lumen.
The endoplasmic reticulum (ER) and its specialized subcompartments such as the sarcoplasmic reticulum, is the main dynamic Ca2+ storage compartment of the cell. Key cellular functions are regulated, either directly or indirectly, by the free Ca2+ concentration in the ER. This article discusses the properties of Ca2+ storage in the ER and considers the functions that appear to be regulated by the Ca2+ stores within the ER, both in and around the ER and at a distance from it.
Meldolesi
J
J
Department of Pharmacology, B. Ceccarelli Center of Neurobiology, University of Milano, Italy.
Pozzan
T
T
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology; D002451:Cell Compartmentation; D004721:Endoplasmic Reticulum / Q000502:physiology*; D006801:Humans; D008954:Models, Biological
D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D002118:Calcium