[Effect of the fibrinous sorbent Akvalen on survival and spontaneous tumorigenesis in mice].
SHP female mice were fed 100 mg/kg carbonic fibrilous sorbent Akvalen 5 times a week, from the age of 3 months until death. The treatment failed to have a significant influence on body weight dynamics or mean lifespan. However, sorbent-treated animals survived 4 months longer until 90% of them died. Although there were no significant differences in the frequency of either all or only malignant tumors between study group and controls, the former showed fewer multiple tumors (1.4 times) as well as a tendency of decreased incidence of neoplasms of the hemopoietic system and uterine polyps. Tumor-bearing sorbent-treated mice survived 4 months longer, while those with malignant tumors only survived 5 months longer (p < 0.05). The investigation failed to detect any carcinogenicity of Akvalen. It is suggested that the sorbent possesses certain geroprotective and anti-tumor properties.
Anisimov
V N
VN
Prof. N.N.Petrov Research Institute of Oncology, Ministry of Health of the RF, St.Petersburg.
Zabezhinskiĭ
M A
MA
Popovich
I G
IG
Liberman
A I
AI
Schmidt
J L
JL
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002244:Carbon / Q000494:pharmacology*; D005260:Female; D005337:Fibrin; D051379:Mice; D016019:Survival Analysis
C110642:Akvalen; D000970:Antineoplastic Agents; D002244:Carbon; D005337:Fibrin
Vliianie voloknistogo sorbenta Akvalen na prodolzhitel'nost' zhizni i vozniknovenie spontannykh opukholeĭ u mysheĭ.