[Genetic polymorphism of FXIII B subunit in seven Chinese populations].
OBJECTIVE
To understand the distribution of allele frequencies of blood factor XIIIB subunit(FXIIIB) in Chinese populations and evaluate the genetic polymorphism of FXIIIB for the purposes of population genetics and forensic haemogenetics.


METHODS
The genetic polymorphism of FXIIIB subunit in seven Chinese populations was investigated. Isoelectrofocusing technique on polyoacrylamid gels followed by immunoblotting was used to determine the phenotype of individuals in each population sample.


RESULTS
There were three common alleles in all the seven Chinese populations. The frequency of FXIIIB*3 was the highest, that of FXIIIB*2 was the lowest, and the one of FXXIIIB*1 was at the middle. All of them reached to the polymorphism's level. A rare variant allele was also found in some Chinese populations. Comparison of the constituents of FXIIIB phenotypes in the seven populations showed that there was no significant difference (P>0.05). The distribution of the allele frequencies in these populations reflected most likely the mode of the distribution in all Chinese populations. The phylogenetic tree and genetic distance, based on the allele frequencies of FXIIIB differentiated the populations in the world into the main ethnic groups as what other authors reported.


CONCLUSIONS
FXIIIB is a useful genetic marker for population genetics and forensic haemogenetics.
Chen
L
L
Institute of Forensic Medicine, West China University of Medical Sciences, Chengdu, 610041 R.P. China.
Hou
Y
Y
Jin
Z
Z
Wu
J
J
Li
Y
Y
Gou
Q
Q
Xu
P
P
D002681:China / Q000208:ethnology; D005174:Factor XII / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D007525:Isoelectric Focusing; D011110:Polymorphism, Genetic
D005174:Factor XII