title: Value of routine, non-targeted biopsies in the diagnosis of gastric neoplasia.
abstract: OBJECTIVE
  To explore how often a diagnosis of gastric neoplasia is made on routine, non-targeted biopsies taken for determination of Helicobacter pylori status, compared with directed biopsies from endoscopically abnormal mucosa.
  
  
  METHODS
  Records of all patients with a biopsy diagnosis of gastric cancer or dysplasia during a two year period were reviewed to determine whether the biopsy had been targeted at an area of mucosal abnormality, and whether there was any evidence of dysplasia or malignancy before endoscopy.
  
  
  RESULTS
  Of the 8907 endoscopic examinations that included biopsy, histology showed malignancy in 115 cases and dysplasia in 20. Of these, in 128 cases the biopsies were targeted from focal abnormal areas of mucosa, and six were from areas of diffuse mucosal thickening. In one case, adenocarcinoma was diagnosed in a patient with a "normal" endoscopic appearance; this patient was undergoing repeat endoscopy for previous dysplasia.
  
  
  CONCLUSIONS
  Gastric malignancy or dysplasia was detected histologically in 1.5% of endoscopies that included biopsy. The performance of routine biopsies not targeted at a visible lesion from patients without previous diagnosis of neoplasia did not increase the detection of gastric malignancy. Such biopsies are indicated, however, if histological aspects of a patient's gastritis (such as atrophy or intestinal metaplasia) influence the clinical management, as in the treatment of helicobacter gastritis.
authors.affiliation: Department of Histopathology, Leeds General Infirmary, UK.
authors.forename: B
authors.initials: B
authors.lastname: Cadman
authors.forename: M F
authors.initials: MF
authors.lastname: Dixon
authors.forename: J I
authors.initials: JI
authors.lastname: Wyatt
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D001706:Biopsy; D002276:Carcinoid Tumor / Q000473:pathology; D005753:Gastric Mucosa / Q000382:microbiology* / Q000473:pathology; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D008223:Lymphoma / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000473:pathology*