title: Phenytoin toxicity in an older patient with slow metabolism and atypical presentation.
abstract: Phenytoin toxicity occurred in an older man who received a dosage of 300 mg/day. The patient developed high serum phenytoin concentrations from this common adult dosage, with symptoms of functional decline and altered mental status. These behaviors were perceived as sun-downing and were treated with haloperidol. A long hospitalization was required.
authors.affiliation: Division of Geriatrics and Extended Care, Ralph H. Johnson V.A. Medical Center, and Medical University of South Carolina, Charleston 29401-5799, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Pitner
authors.forename: L D
authors.initials: LD
authors.lastname: Long
authors.forename: R P
authors.initials: RP
authors.lastname: Meyer
authors.forename: L C
authors.initials: LC
authors.lastname: Pennypacker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000009:adverse effects* / Q000378:metabolism*; D003704:Dementia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000378:metabolism*; D012640:Seizures / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin