title: Eprinomectin: a novel avermectin for control of lice in all classes of cattle.
abstract: Eight trials were conducted in the United States to determine the efficacy of eprinomectin applied topically against four common species of lice in cattle. In two dose titration trials, eprinomectin dosages of 125 to 750 mcg/kg body weight applied topically were compared to untreated controls. In dose confirmation studies, animals treated topically with eprinomectin applied at the rate of 500 mcg/kg were compared to vehicle-treated controls. Four species of lice were present in these trials: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus, all sucking lice, and Damalinia (Bovicola) bovis, the cattle biting louse. Louse counts were made on six to nine predilection sites (the same number of sites in all animals in the same trial) prior to treatment. The same sites were counted again seven days after treatment and weekly thereafter until trial termination eight weeks after treatment. When no lice were found in the predilection sites, a modified whole body search was conducted. Each species of lice was present on at least six animals in each treatment group on at least one counting date in two or more trials. No lice were found on any animal treated topically with eprinomectin at a dosage of > or = 500 mcg/kg after 14 days posttreatment until termination of the trials eight weeks after treatment.
authors.affiliation: Merck, Rahway, NJ 07065, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Holste
authors.forename: L L
authors.initials: LL
authors.lastname: Smith
authors.forename: J A
authors.initials: JA
authors.lastname: Hair
authors.forename: J L
authors.initials: JL
authors.lastname: Lancaster
authors.forename: J E
authors.initials: JE
authors.lastname: Lloyd
authors.forename: W K
authors.initials: WK
authors.lastname: Langholff
authors.forename: R A
authors.initials: RA
authors.lastname: Barrick
authors.forename: J S
authors.initials: JS
authors.lastname: Eagleson
mesh_terms: D000818:Animals; D000854:Anoplura; D002417:Cattle; D002418:Cattle Diseases; D004305:Dose-Response Relationship, Drug; D005260:Female; D007306:Insecticides / Q000627:therapeutic use*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010373:Lice Infestations / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D008003:Phthiraptera
chemical_list: D007306:Insecticides; D007559:Ivermectin; C101434:eprinomectin