title: Marrow versus infection in the Charcot joint: indium-111 leukocyte and technetium-99m sulfur colloid scintigraphy.
abstract: This study evaluated the role of combined leukocyte/marrow scintigraphy in the assessment of the neuropathic or Charcot joint.
  
  
  METHODS
  Seventeen patients with (111)In-labeled leukocyte accumulation in 20 radiographically confirmed Charcot joints underwent 99mTc-sulfur colloid marrow scintigraphy. Studies demonstrating labeled leukocyte accumulation without corresponding activity on marrow images were classified as positive for osteomyelitis. Six of the patients also underwent three-phase bone scintigraphy. Bone scans were interpreted as positive for osteomyelitis when focal hyperperfusion, focal hyperemia and focal bony uptake on delayed images were present. Bone images were also interpreted together with labeled leukocyte images using two different criteria for a positive study. One criterion was the presence of labeled leukocyte activity in a region demonstrating abnormal activity on the bone scan, which was more intense than adjacent marrow activity or marrow activity in the corresponding region of the contralateral foot. The second criterion was either a spatially incongruent distribution of the two tracers or hyperintense activity on the leukocyte study, as compared to the bone scan.
  
  
  RESULTS
  Leukocyte/marrow studies were positive for osteomyelitis in 4 of the 20 neuropathic joints. Osteomyelitis was present in three of the four joints, whereas in the fourth, infection was confined to overlying soft tissues. None of the 16 neuropathic joints with negative leukocyte/marrow scans were infected. In one patient who underwent below-the-knee amputation, histological analysis confirmed the presence of hematopoietically active marrow corresponding to areas of congruent activity on the leukocyte and marrow images. Three-phase bone scintigraphy was positive in all six neuropathic joints studied; osteomyelitis was present in two of them. Using the first criterion, leukocyte/bone imaging was also positive in all six. Using the second criterion, leukocyte/bone imaging was positive in the two infected neuropathic joints, as well as in three uninfected ones. Leukocyte/marrow scintigraphy was positive in both infected joints and negative in the four without infection.
  
  
  CONCLUSIONS
  Labeled leukocyte accumulation in the uninfected Charcot joint does occur and is related, at least in part, to hematopoietically active marrow. Leukocyte/marrow scintigraphy is a reliable way to differentiate between marrow and infection as the cause of labeled leukocyte accumulation in the neuropathic joint and, in this series, was superior to both three-phase bone scintigraphy and combined leukocyte/bone scintigraphy.
authors.affiliation: Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Palestro
authors.forename: H H
authors.initials: HH
authors.lastname: Mehta
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: S J
authors.initials: SJ
authors.lastname: Freeman
authors.forename: W N
authors.initials: WN
authors.lastname: Harrington
authors.forename: M B
authors.initials: MB
authors.lastname: Tomas
authors.forename: S E
authors.initials: SE
authors.lastname: Marwin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001177:Arthropathy, Neurogenic / Q000000981:diagnostic imaging*; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007596:Joints / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid