title: Hazards of inadequate fluconazole dosage to treat deep-seated or systemic Candida albicans infection.
abstract: We report three cases of deep-seated and systemic Candida albicans infection in which inadequate dosages of fluconazole were used, leading to breakthrough fungaemia, candidal osteomyelitis and endocarditis. The need to modify fluconazole dosage in patients receiving continuous venovenous haemofiltration is discussed.
authors.affiliation: Department of Medical Microbiology, University Hospital of Wales, Cardiff, UK.
authors.forename: P G
authors.initials: PG
authors.lastname: Flanagan
authors.forename: R A
authors.initials: RA
authors.lastname: Barnes
mesh_terms: D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000671:Amputation, Surgical; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001174:Arthrodesis; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D004172:Diplopia / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D005437:Flucytosine / Q000627:therapeutic use; D006440:Hemofiltration; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000150:complications; D010019:Osteomyelitis / Q000601:surgery; D012123:Pulmonary Ventilation; D014821:Vitrectomy
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine