[Pathogenetic aspects of urinary tract infection].
Most urinary tract infections are caused by Enterobacteriaceae; E. coli-strains dominating in 50 to 80% of primary infections. Microorganisms possessing the ability to colonize the uroepithelium (fimbriae/pili) and to cytotoxically damage of cells (hemolysin) may initiate acute infections. On the other hand, properties favouring the survival of these strains in the tissue (K-antigen, iron sequestering/aerobactin) tend to produce relapse and/or chronic infection. A variety of host-specific factors, especially glycosphingolipids, on the surface of epithelial cells determine the virulence of pathogenic microorganisms in the urinary tract and the course of a disease. Structural damages resulting from intra- or extrarenal obstructions, disturbances of the urinary flow and metabolic disorders are essential, predisposing factors of a host organism. These different factors and interactions of these mechanisms determine the manifestation and course of urinary tract infections.
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Klinik für Innere Medizin IV, Friedrich-Schiller-Universität, Jena, Deutschland.
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D001437:Bacteriuria; D004927:Escherichia coli Infections / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D008297:Male; D014552:Urinary Tract Infections / Q000145:classification / Q000175:diagnosis / Q000382:microbiology*; D014556:Urine / Q000382:microbiology; D014774:Virulence
Pathogenetische Aspekte der Harnwegsinfektion.