[The testicular feminization syndrome--a report of 9 cases].
We present the data of analysis of 9 cases (girls and young women) aged 14 to 20 years, with syndrome of testicular feminisation. The patients were diagnosed and treated at the departments of Paediatric and Adolescent Gynaecology and of Gynaecological Endocrinology at the University Ob. & Gyn. hospital in Sofia. The diagnosis was based on the clinical picture, karyogram and radioimmunoassay of gonadotropic and sex hormones. Described were some data as family history, clinical picture, from of the disease, appearance, genital and hormonal status, and histodiagnosis of the removed gonads. Out of nine, primarily diagnosed as a syndrome of testicular feminisation girls and women one ws with an incomplete from, in another further investigations evoked a suspicion of Swyer syndrome (a 14-years-old girl, on whom surgical treatment due to big gonadoblastoma was performed, she died a year later). One patient also developed an ovarian tumour, in six we performed gonadectomy. One patient did not come for any treatment. The differential diagnosis with some relatively rare syndromes, as well as the treatment of this patients were discussed.
Sirakov
M
M
Kolarov
G
G
Veltova
L
L
Nalbanski
B
B
D000293:Adolescent; D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000175:diagnosis* / Q000601:surgery; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004407:Dysgerminoma / Q000175:diagnosis / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D018238:Gonadoblastoma / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007621:Karyotyping; D008297:Male; D009919:Orchiectomy; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000601:surgery; D010052:Ovariectomy; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000601:surgery
Kŭm sindroma na testikularnata feminizatsiia--s prinos ot 9 sluchaia.