title: Polioencephalomalacia.
abstract: Polioencephalomalacia (PEM) is a neuropathologic condition of ruminants that can be induced by a variety of neural metabolic disruptions. These include altered thiamine status, water deprivation-sodium ion toxicosis, lead poisoning, and high sulfur intake. Investigations of sulfur-related PEM have demonstrated that the onset of the clinical signs coincides with excessive ruminal sulfide production. A number of ruminal factors could modulate the production and absorption of ruminal sulfide. The development of a convenient method to estimate ruminal gas cap H2S has made it possible to identify cattle with high levels of ruminal H2S and evaluate their risk of developing PEM.
authors.affiliation: Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: Gould
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism*; D004678:Encephalomalacia / Q000453:epidemiology / Q000378:metabolism / Q000662:veterinary*; D006862:Hydrogen Sulfide / Q000032:analysis / Q000378:metabolism; D015994:Incidence; D012307:Risk Factors; D012417:Rumen / Q000737:chemistry / Q000378:metabolism; D012418:Ruminants; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D013440:Sulfides / Q000032:analysis / Q000378:metabolism*; D013831:Thiamine / Q000378:metabolism
chemical_list: D013440:Sulfides; D012964:Sodium; D013831:Thiamine; D006862:Hydrogen Sulfide