title: Structural insights into DNA polymerase beta fidelity: hold tight if you want it right.
abstract: DNA polymerases must select and incorporate the correct deoxynucleoside 5'-triphosphate from a pool of structurally similar molecules. The structural and kinetic characterization of DNA polymerase beta indicates that this polymerase must stabilize the templating base to achieve efficient polymerization with high fidelity.
authors.affiliation: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Beard
authors.forename: S H
authors.initials: SH
authors.lastname: Wilson
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D004247:DNA / Q000096:biosynthesis; D019951:DNA Polymerase beta / Q000737:chemistry* / Q000378:metabolism; D004261:DNA Replication; D003854:Deoxyribonucleotides / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D003854:Deoxyribonucleotides; D004247:DNA; D019951:DNA Polymerase beta