In-vitro susceptibility of Helicobacter pylori to ampicillin, clarithromycin, metronidazole and omeprazole.
The in-vitro activities of omeprazole and three antimicrobial agents against 89 clinical isolates of Helicobacter pylori from a population with duodenal ulcer disease were determined by an agar dilution method. Resistance rates were 20% for metronidazole (MIC > 8 mg/L), 1% for clarithromycin (MIC > 2 mg/L) and zero for ampicillin (MIC > 8 mg/L). Omeprazole was relatively active against H. pylori in vitro (MIC < or = 8 mg/L).
Loo
V G
VG
Department of Microbiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
Fallone
C A
CA
De Souza
E
E
Lavallée
J
J
Barkun
A N
AN
D000667:Ampicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009853:Omeprazole / Q000494:pharmacology*; D011792:Quebec
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D000667:Ampicillin; D017291:Clarithromycin; D009853:Omeprazole