Meta-analyses of dietary fats and mammary neoplasms in rodent experiments.
We review two meta-analyses of experiments on dietary fat and mammary tumor incidence in rodents, emphasizing a recent meta-analysis on the effects of different types of dietary fatty acids. This analysis shows that n-6 polyunsaturated fatty acids most strongly enhance mammary tumors in rodents, and saturated fats also enhance these tumors but less strongly. Further, the analysis shows that energy restriction protects against mammary tumors. We show that these results agree qualitatively with estimates of effects on human breast cancer derived from international correlations.
Fay
M P
MP
Biometry Branch, National Cancer Institute, Bethesda, MD 20892-7354, USA. m7f@helix.nih.gov
Freedman
L S
LS
D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology; D004041:Dietary Fats / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000209:etiology*; D012377:Rodentia
D004041:Dietary Fats