[Palladium-containing compounds possess radiation-protective properties and enhance adaptive response of CFUs to radiation].
Efasol and potassium tetrachloropalladate being injected into mice prior to irradiation with a dose of 150 sGy increase the colony forming activity of animals bone marrow cells transplanted in lethally irradiated recipient mice. The palladium presence in such compounds is supposed to be a reason of radioprotection. Upon the combined application of potassium tetrachloropalladate and irradiation of mice with an adaptive dose of 5 sGy a potentiation of individual effect of each separate agent to increase CFUs resistance against the consequent irradiation was observed.
Semenets
T N
TN
Medical Radiological Research Centre of Russian Academy of Medical Science, Obninsk.
Semina
O V
OV
Efimenko
I A
IA
Ivanova
N A
NA
Poverennyĭ
A M
AM
D000220:Adaptation, Biological; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects*; D016026:Bone Marrow Transplantation; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010165:Palladium / Q000494:pharmacology*; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013997:Time Factors
D011837:Radiation-Protective Agents; C030174:tetrachloropalladium; D010165:Palladium
Palladiĭsoderzhashchie soedineniia obladaiut radioprotektivnymi svoĭstvami i usilivaiut adaptivnyĭ otvek KOEs k radiatsionnomu vozdeĭstviiu.