The aged suprachiasmatic nucleus is phase-shifted by cAMP in vitro.
The cyclic adenosine monophosphate (cAMP) analog, 8-bromo-cAMP, phase advanced circadian neuronal rhythms in both aged and adult rat suprachiasmatic nuclei (SCN) by approximately 2 h in vitro. Rhythm amplitude was 20% lower in aged compared to adult SCN. The diminished efficacy of serotonergic agonists to phase shift behavioral rhythms of aged animals may be due to decrements in signal transduction mechanisms proximal to cAMP.
Ruby
N F
NF
Department of Biological Sciences, Stanford University, CA 94305, USA. ruby@leland.stanford.edu
Edgar
D M
DM
Heller
H C
HC
Miller
J D
JD
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D000242:Cyclic AMP / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344; D013493:Suprachiasmatic Nucleus / Q000187:drug effects*
D015124:8-Bromo Cyclic Adenosine Monophosphate; D000242:Cyclic AMP