[Comparative analysis of the effects of clonidine preparations depending on methods of arterial pressure recording].
Changes in hemodynamic parameters in intravenous infusion of drugs of the clonidine group were studied in Wistar rats by means of the radio-telemetry and catheter systems of arterial pressure (AP) recording. Clonidine (5 micrograms/kg), rilmenidine (300 micrograms/kg), and moxonidine (100 micrograms/kg) were found to cause significant decrease in AD and bradycardia whatever the method of AD measurement used. However, the degree of the hypotensive and negative cardiochronotropic effects of the central action drugs was higher in rats with radio-telemetry transmitters. The results provide evidence that the radio-telemetry system of monitoring of the hemodynamic parameters is more sensitive and accurate for evaluating the effect of the drugs under study.
Kunduzova
O R
OR
Lomonosov Moscow State University, Moscow, Russia.
Murashev
A N
AN
Medvedeva
N A
NA
Medvedev
O S
OS
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000379:methods; D002404:Catheterization; D003000:Clonidine / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D010080:Oxazoles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000077769:Rilmenidine; D013686:Telemetry / Q000379:methods
D000959:Antihypertensive Agents; D007093:Imidazoles; D010080:Oxazoles; C043482:moxonidine; D003000:Clonidine; D000077769:Rilmenidine
Sravnitel'nyĭ analiz éffektov preparatov gruppy klonidina v zavisimosti ot metodov registratsii arterial'nogo davleniia.