The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor.
With the purification and cloning of the interferon gamma (IFN-gamma) receptor chains the mechanism of IFN-gamma action and the resultant signal transduction events were delineated in remarkable detail. The interferon gamma (IFN-gamma) receptor complex consists of two chains: IFN-gammaR1, the ligand-binding chain, and IFN-gammaR2, the accessory chain. Binding of IFN-gamma causes oligomerization of the two IFN-gamma receptor subunits, IFN-gammaR1 and IFN-gammaR2, which initiates the signal transduction events: activation of Jak1 and Jak2 receptor associated protein tyrosine kinases, phosphorylation of the IFN-gammaR1 intracellular domain on Tyr440 followed by phosphorylation and activation of Stat1alpha, the latent transcriptional factor. With all these steps established, the IFN-gamma receptor complex has provided the basic model for understanding the receptors for other members of the family of class II cytokine receptors.
Pestka
S
S
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Kotenko
S V
SV
Muthukumaran
G
G
Izotova
L S
LS
Cook
J R
JR
Garotta
G
G
D000818:Animals; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D008954:Models, Biological; D017471:Receptors, Interferon / Q000235:genetics* / Q000502:physiology*
D017471:Receptors, Interferon; D007371:Interferon-gamma