An allelic association study of two polymorphic markers in close proximity to a balanced translocation t(1:11) that co-segregates with mental illness.
We report a case control association study using polymorphic markers D1S1621 and D11S931 in unrelated individuals with schizophrenia, unipolar depression and a matched control group. The two polymorphic markers were identified during the positional cloning of the translocation breakpoint t(1:11)(q43:q14.3) that cosegregates with schizophrenia and affective disorders. These markers provided an opportunity to investigate linkage disequilibrium with a postulated schizophrenia susceptibility gene close to the translocation breakpoint in random populations of schizophrenia and unipolar depression individuals compared with a normal control population. No significant differences between allele frequencies for either of the markers in the affected populations were observed in comparison with the control group, which provides evidence against a nearby gene of major effect in the populations studied.
Wilson-Annan
J C
JC
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK. Juliew@hgu.mrc.ac.uk
Blackwood
D H
DH
Muir
W
W
Millar
J K
JK
Porteous
D J
DJ
D000483:Alleles; D016022:Case-Control Studies; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D003627:Data Interpretation, Statistical; D003863:Depression / Q000235:genetics; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics; D014178:Translocation, Genetic
D005819:Genetic Markers