Regional distribution of glutamate receptor mRNA in the monkey hippocampus and temporal cortex: influence of estradiol.
The distribution of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) glutamate receptor subunits was examined in the hippocampus and temporal cortex of adult ovariectomized female rhesus macaques, some of which received estradiol replacement. In situ hybridization revealed a generalized overlap of NR1, GluR1, and GluR2 subunit mRNAs, but no effect due to estradiol treatment. However, regional differences in expression were noted for each subunit.
Kohama
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SG
Division of Neuroscience, Oregon Regional Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006, USA.
Garyfallou
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VT
Urbanski
H F
HF
D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D017403:In Situ Hybridization; D008253:Macaca mulatta; D009474:Neurons / Q000378:metabolism*; D009928:Organ Specificity; D010052:Ovariectomy; D012333:RNA, Messenger / Q000378:metabolism*; D018091:Receptors, AMPA / Q000096:biosynthesis*; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis*; D013702:Temporal Lobe / Q000187:drug effects / Q000378:metabolism*
D004958:Estradiol; D012333:RNA, Messenger; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; C104722:glutamate receptor ionotropic, AMPA 2