Induction of apoptosis in human stomach cancer cells by green tea catechins.
The exposure of human stomach cancer KATO III cells to green tea catechin extract and epigallocatechin gallate (EGCG), a main component of the extract led to both growth inhibition and the induction of programmed cell death (apoptosis). Morphological changes showing apoptotic body were observed in the cells treated with green tea catechin extract and EGCG. The fragmentation of DNA to oligonucleosomal-sized fragments, characteristic of apoptosis was determined to be concentration- and time-dependent. These data suggest that drinking of green tea in large amounts is recommended possibly to protect humans from stomach cancer.
Hibasami
H
H
Faculty of Medicine, Mie University, Tsu-city, Mie 514, Japan.
Komiya
T
T
Achiwa
Y
Y
Ohnishi
K
K
Kojima
T
T
Nakanishi
K
K
Akashi
K
K
Hara
Y
Y
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010936:Plant Extracts; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*; D013662:Tea; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D010936:Plant Extracts; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate