Role of QT interval prolongation in the creation of spiral wave type reentry.
The inducibility of reentry was compared for four QT patterns in a heart conduction simulation model. Local (L) and gradual (G) QT prolongation models are more susceptible to reentry induction than the no (N) QT prolongation model (reentry induced episodes for N, L, and G numbered 90, 120, and 122, respectively). This increased vulnerability was diminished when the QT interval was prolonged at all simulation sites (reentry induced episodes for the diffuse QT prolongation model, D model, numbered 82). Decreased QT dispersion might be important for the prevention of reentry induction regardless of whether the QT interval is increased.
Shibata
N
N
Department of Cardiology, Heart Institute of Japan, Tokyo Women's Medical College, Japan.
Watanabe
H
H
Sakuma
I
I
Kodama
I
I
Niwa
R
R
Fukui
Y
Y
Toyama
J
J
Hosoda
S
S
D000200:Action Potentials; D004558:Electric Stimulation; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular