[The depression of the reproduction of the human immunodeficiency virus by the use of Bogomolets antireticular cytotoxic serum].
The action of the Bogomolets' antireticular cytotoxic serum (ACS) as a HIV-1 reproduction inhibitor was studied on the model of human lymphoblastoid cell line MT-4/BRU (acute infection). The HIV-1 reproduction inhibition was estimated according to cell protection level for virus cytopathic action and p24 antigen level in the cultural media. The both tests data on ACS usage in dilutions 1:160-1:640 prove that the virus inhibition effect which may be compared with anti-HIV action of the well-known agent, azidothymidine, was observed. At this dilutions range ACS is devoid of the cell toxicity. The conclusion about perspectivity of ACS usage in the AIDS complex therapy was drawn.
Spivak
M Ia
MIa
Karpov
O V
OV
Antonenko
S V
SV
Barbasheva
O V
OV
Kvielienkova
K I
KI
Voloshchenko
Iu V
IuV
D019380:Anti-HIV Agents / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D013997:Time Factors; D014407:Tumor Cells, Cultured; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects* / Q000502:physiology
D019380:Anti-HIV Agents; D007106:Immune Sera; C092051:antireticular cytotoxic serum
Pryhnichennia reproduktsiï virusu imunodefitsytu liudyny za dopomohoiu antyretykuliarnoï tsytotoksychnoï syrovatky Bohomol'tsia.