title: Role of gamma delta T cells in immunity to infectious diseases and the regulation of hematolymphoid cell development.
abstract: My research interests are twofold. The first is to define the biochemical and molecular mechanisms that regulate hematopoietic cell development. In particular, the role that the cytokine interleukin-2 (IL2) plays in regulating the development and selection of lymphocyte progenitor cells, and in myelopoiesis are primary areas of research. The second is to understand the role that gamma delta T cells play in pathogen-induced immune responses and autoimmunity. Their involvement in the immune response to the intracellular bacteria Listeria monocytogenes in mice and Mycobacteria tuberculosis (Mtb) in humans, in T cell-mediated inflammatory bowel disease in humans, and the nature of the antigens they recognize during these responses are major areas of interest. Research material includes patient-derived tissues as well as both conventional and genetically engineered (transgenic) strains of mice.
authors.affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6076, USA. carding@mail.med.upenn.edu
authors.forename: S R
authors.initials: SR
authors.lastname: Carding
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D003141:Communicable Diseases / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta