title: Short-pulse carbon dioxide laser resurfacing in the treatment of rhytides and scars. A clinical and histopathological study.
abstract: BACKGROUND
  Previous studies have shown the efficacy of short-pulse carbon dioxide (CO2) lasers in the treatment of rhytides and scars. To date, there have been few studies examining the histological aspects of these treatments.
  
  
  OBJECTIVE
  The purpose of this study was to perform a prospective clinical and histopathological study of CO2 laser resurfacing for improvement of facial rhytides and scars.
  
  
  METHODS
  A total of 23 patients were studied. Clinical improvement was evaluated both pre- and postoperatively using photographs and optical profilometry. Skin biopsies of rhytides were also obtained.
  
  
  RESULTS
  Postoperatively, rhytides and scars both demonstrated significant increases in clinical improvement scores. Results from optical profilometry studies reflected these results. Skin biopsies from rhytides posttreatment demonstrated increases in collagen layer thickness. Improvement was sustained as late as 1 year following treatment.
  
  
  CONCLUSIONS
  Histopathological studies suggest improvement of rhytides and scars by CO2 laser resurfacing may be attributed to new collagen formation following treatment.
authors.affiliation: Ronald O. Perelman Department of Dermatology, New York University Medical Center, New York, USA.
authors.forename: E
authors.initials: E
authors.lastname: Shim
authors.forename: Y
authors.initials: Y
authors.lastname: Tse
authors.forename: E
authors.initials: E
authors.lastname: Velazquez
authors.forename: H
authors.initials: H
authors.lastname: Kamino
authors.forename: V
authors.initials: V
authors.lastname: Levine
authors.forename: R
authors.initials: R
authors.lastname: Ashinoff
mesh_terms: D002921:Cicatrix / Q000473:pathology / Q000601:surgery*; D062109:Dermatologic Surgical Procedures; D005145:Face / Q000601:surgery*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D015361:Rhytidoplasty; D012867:Skin / Q000473:pathology; D015595:Skin Aging