title: Up-regulation of beta-actin, cyclophilin and GAPDH in N1S1 rat hepatoma.
abstract: Beta-actin, cyclophilin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are all constantly expressed proteins that regulate cellular structures and endogenous cytoarchitectural functions. In this study, we used an in vivo N1S1 rat hepatoma model to examine changes in the expression levels of these housekeeping genes in normal and tumor liver samples. The beta-actin, cyclophilin and GAPDH genes were all up-regulated in tumor groups as compared to the controls. Our results suggest that up-regulation of beta-actin, cyclophilin and GAPDH genes may be essential for oncogenesis in hepatoma.
authors.affiliation: Department of Medical Research and Education, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: T J
authors.initials: TJ
authors.lastname: Chang
authors.forename: C C
authors.initials: CC
authors.lastname: Juan
authors.forename: P H
authors.initials: PH
authors.lastname: Yin
authors.forename: C W
authors.initials: CW
authors.lastname: Chi
authors.forename: H J
authors.initials: HJ
authors.lastname: Tsay
mesh_terms: D000199:Actins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D015152:Blotting, Northern; D005786:Gene Expression Regulation / Q000235:genetics*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000235:genetics / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009368:Neoplasm Transplantation; D019696:Peptidylprolyl Isomerase / Q000235:genetics / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000302:isolation & purification / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015854:Up-Regulation
chemical_list: D000199:Actins; D012334:RNA, Neoplasm; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D019696:Peptidylprolyl Isomerase