title: In-vitro susceptibility of Helicobacter pylori to ampicillin, clarithromycin, metronidazole and omeprazole.
abstract: The in-vitro activities of omeprazole and three antimicrobial agents against 89 clinical isolates of Helicobacter pylori from a population with duodenal ulcer disease were determined by an agar dilution method. Resistance rates were 20% for metronidazole (MIC > 8 mg/L), 1% for clarithromycin (MIC > 2 mg/L) and zero for ampicillin (MIC > 8 mg/L). Omeprazole was relatively active against H. pylori in vitro (MIC < or = 8 mg/L).
authors.affiliation: Department of Microbiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: V G
authors.initials: VG
authors.lastname: Loo
authors.forename: C A
authors.initials: CA
authors.lastname: Fallone
authors.forename: E
authors.initials: E
authors.lastname: De Souza
authors.forename: J
authors.initials: J
authors.lastname: Lavallée
authors.forename: A N
authors.initials: AN
authors.lastname: Barkun
mesh_terms: D000667:Ampicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009853:Omeprazole / Q000494:pharmacology*; D011792:Quebec
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D000667:Ampicillin; D017291:Clarithromycin; D009853:Omeprazole