title: Conjunctival necrosis following the administration of subconjunctival corticosteroid.
abstract: This report describes an unusual reaction to injected subconjunctival corticosteroid. The authors examined a patient with large areas of conjunctival necrosis at the site of a previous subconjunctival corticosteroid injection. A Gram's strain and culture of the affected conjunctival area and the bottled corticosteroid suspension were negative. Necrosis of the conjunctiva is a heretofore unreported adverse reaction to a subconjunctival corticosteroid injection. These lesions probably represent a localized toxic reaction rather than a sequela of infection.
authors.affiliation: Wills Eye Hospital, Philadelphia, PA 19107, USA.
authors.forename: T
authors.initials: T
authors.lastname: Kim
authors.forename: C J
authors.initials: CJ
authors.lastname: Rapuano
authors.forename: R C
authors.initials: RC
authors.lastname: Rodman
authors.forename: J F
authors.initials: JF
authors.lastname: Vander
authors.forename: E J
authors.initials: EJ
authors.lastname: Cohen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003228:Conjunctiva / Q000187:drug effects* / Q000473:pathology; D003229:Conjunctival Diseases / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007267:Injections; D008269:Macular Edema / Q000188:drug therapy; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077555:Methylprednisolone Acetate; D009336:Necrosis
chemical_list: D000893:Anti-Inflammatory Agents; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone