title: Vincristine therapy for mast cell tumors in dogs.
abstract: Twenty-seven dogs with naturally occurring mast cell tumors were treated with weekly i.v. injections of vincristine (0.75 mg/m2) for 4 treatments. Two dogs (7%) had a partial response. Nine dogs (32%) had treatment stopped prematurely because of toxicity or a perceived deterioration in their quality of life. We conclude that vincristine is ineffective as a sole treatment for measurable mast cell tumors in dogs and produces an undesirable number of adverse reactions.
authors.affiliation: Department of Veterinary Medicine and Surgery, University of Missouri, Columbia 65211, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: McCaw
authors.forename: M A
authors.initials: MA
authors.lastname: Miller
authors.forename: P J
authors.initials: PJ
authors.lastname: Bergman
authors.forename: S J
authors.initials: SJ
authors.lastname: Withrow
authors.forename: A S
authors.initials: AS
authors.lastname: Moore
authors.forename: D W
authors.initials: DW
authors.lastname: Knapp
authors.forename: D
authors.initials: D
authors.lastname: Fowler
authors.forename: J C
authors.initials: JC
authors.lastname: Johnson
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D012515:Mast-Cell Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D009919:Orchiectomy; D010052:Ovariectomy; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine