title: Heart rate variability in patients with familial amyloid polyneuropathy.
abstract: The purpose of this study was to evaluate heart rate variability (HRV) in patients with familial amyloid polyneuropathy (FAP) using the time- and frequency-domain analysis. The study population consisted of 19 patients with FAP, and 19 age and sex matched normal volunteers. The 24-hour Holter recordings of all subjects in sinus rhythm and off medication were analyzed. Five time-domain indices of HRV were computed. The frequency component of HRV was calculated by fast Fourier transform analysis of the RR intervals. The power spectrum of the low frequency (LF) between 0.04-0.15 Hz and high frequency (HF) between 0.15-0.40 Hz and the LF/HF ratio was calculated. Global measures of HRV including the standard deviation of the mean of RR intervals (SDNN) and the standard deviation of 5-minute mean RR intervals (SDANN) were decreased in patients with FAP. Specific vagal influences on HRV including the proportion of RR intervals more than 50 milliseconds different (pNN50) and the HF power on spectral analysis were less in patients with FAP. LF power and LF/HF ratio were more decreased in patients with FAP at the advanced stage than at the early stage. In conclusion, HRV was significantly decreased in patients with FAP at the early stage, and sympathetic activity was more decreased in patients at the advanced stage. These findings suggest that the decrease of the HRV is an indicator of this disease and the power spectral analysis of the HRV is beneficial in assessing the severity of the autonomic dysfunction.
authors.affiliation: First Department of Internal Medicine, Shinshu University, Marunouchi Hospital, Matsumoto City, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Kinoshita
authors.forename: M
authors.initials: M
authors.lastname: Hongo
authors.forename: Y
authors.initials: Y
authors.lastname: Saikawa
authors.forename: T
authors.initials: T
authors.lastname: Katsuyama
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Isobe
authors.forename: M
authors.initials: M
authors.lastname: Sekiguchi
mesh_terms: D000328:Adult; D000368:Aged; D017772:Amyloid Neuropathies / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000503:physiopathology; D001706:Biopsy; D015716:Electrocardiography, Ambulatory; D005260:Female; D005583:Fourier Analysis; D006329:Heart Conduction System / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012720:Severity of Illness Index