title: Immune-cell system provides the development of extraneural tumors in the ethyl-nitrosourea model of neurocarcinogenesis.
abstract: Immunological suppression of the immune-cell system by means of cyclosporin-A was performed at a stage corresponding to microtumor development in the ethyl-nitrosourea (ENU) model of neurocarcinogenesis. The results that we have obtained suggest that this immunological manipulation is related to the appearance of extraneural undifferentiated tumors, suggesting that the immune-cell system is effective in immunocompetent rodents for providing extraneural ENU carcinogenesis.
authors.affiliation: Neurosciences Research Unit of the Mapfre-Medicine Foundation, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vaquero
authors.forename: M
authors.initials: M
authors.lastname: Zurita
authors.forename: S
authors.initials: S
authors.lastname: Oya
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced*; D016572:Cyclosporine / Q000494:pharmacology*; D005038:Ethylnitrosourea; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental; D009442:Neurilemmoma / Q000139:chemically induced*; D009837:Oligodendroglioma / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D005038:Ethylnitrosourea