title: Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage.
abstract: The alpha7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity administered 24 h before, but not concomitantly with, NMDA. This action was blocked by nicotinic but not muscarinic antagonists. DMXB (1 mg/kg i.p.) also reduced infarct size in rats when injected 24 h before, but not during, focal ischemic insults. In a mecamylamine-sensitive manner, alpha7 receptors appear neuroprotective in non-apoptotic model.
authors.affiliation: Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shimohama
authors.forename: D L
authors.initials: DL
authors.lastname: Greenwald
authors.forename: D H
authors.initials: DH
authors.lastname: Shafron
authors.forename: A
authors.initials: A
authors.lastname: Akaika
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: S
authors.initials: S
authors.lastname: Kaneko
authors.forename: J
authors.initials: J
authors.lastname: Kimura
authors.forename: C E
authors.initials: CE
authors.lastname: Simpkins
authors.forename: A L
authors.initials: AL
authors.lastname: Day
authors.forename: E M
authors.initials: EM
authors.lastname: Meyer
mesh_terms: D000818:Animals; D001597:Benzylidene Compounds / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011978:Receptors, Nicotinic / Q000502:physiology*
chemical_list: D001597:Benzylidene Compounds; D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D018722:Nicotinic Agonists; D011725:Pyridines; D011978:Receptors, Nicotinic; C088936:3-(2,4-dimethoxybenzylidene)anabaseine