Factors related to axillary lymph node metastasis in T1 breast carcinoma.
The current study was performed on 38 cases of T1 breast cancers ( 2 cm in greatest diameter) to identify the factors related to recognition of axillary lymph node (AxLN) metastasis. Ten patients (26.3%) had lymph node metastases. Comparing the AxLN positive (+) group with the AxLN negative (-) group revealed that tumor size and hormone receptor status as well as age of the patients were not significantly different. However, the Ki-67 labeling index (22.2 +/- 5. 9% vs. 12.5 +/- 2.8%), the microvessel count (43.8 +/- 12.4/0.785 mm2 vs. 27.0 +/- 8.4/0.785 mm2) and bcl-2+ cases (70% vs. 29%) were significantly higher in the AxLN+ cases. These results suggest that the Ki-67 labeling index, microvessel count and Bcl-2 expression, especially when combined, are useful predictors of AxLN metastases in T1 breast cancers.
Singh
Y
Y
Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570, Japan.
Nambu
H
H
Yoshizawa
K
K
Hatano
T
T
Hioki
K
K
Tsubura
A
A
D000328:Adult; D000368:Aged; D001365:Axilla; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008207:Lymphatic Metastasis; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014841:von Willebrand Factor