Possible therapeutic effects of growth hormone on wound healing in the diabetic patient.
Growth factors are increasingly investigated for their role in wound healing. The authors present evidence from human and animal studies suggesting that growth hormone induces a positive nitrogen balance, enhances connective-tissue synthesis, and increases lean body mass. The physiology of diabetes and wound healing is reviewed in the context of how growth hormone therapy could benefit this patient population.
Massey
K A
KA
Pennsylvania College of Podiatric Medicine, Philadelphia 19107, USA.
Blakeslee
C
C
Pitkow
H S
HS
D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000503:physiopathology; D004359:Drug Therapy, Combination; D019382:Human Growth Hormone / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage; D051381:Rats; D013514:Surgical Procedures, Operative; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D007328:Insulin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I