title: [Optimum quinine therapy in falciparum malaria attacks contracted in Africa].
abstract: A review about the use of quinine for uncomplicated falciparum malaria contracted in Africa is proposed. The dose of 8 mg/kg of quinine base 3 times a day seems to be admitted by all. On the other way, the duration of treatment fluctuates from 2 to 10 days without evidence of difference in efficacy between 3, 5 and 7 days. The pharmacodynamic and pharmacokinetic properties of quinine are reviewed and suggest that 3, 5 and 7 days are efficient at least on, respectively, 1, 2 and 3 parasite cycles and suggest that a five day treatment may be curative for all kind of patients infested with a quinine-sensitive strain of P. falciparum in Africa.
authors.affiliation: Service de parasitologie & centre national de référence de la chimiosensibilité du paludisme (CNRCP), Hôpital Bichat-Claude-Bernard, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Clain
authors.forename: G
authors.initials: G
authors.lastname: Peytavin
authors.forename: B
authors.initials: B
authors.lastname: Gachot
authors.forename: F
authors.initials: F
authors.lastname: Vachon
authors.forename: J
authors.initials: J
authors.lastname: Le Bras
mesh_terms: D000349:Africa / Q000208:ethnology; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005602:France / Q000453:epidemiology; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000208:ethnology*; D011803:Quinine / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000962:Antimalarials; D011803:Quinine
vernacular_title: Du bon usage thérapeutique de la quinine dans l'accès palustre à P. falciparum contracté en Afrique.