Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines.
Clone 120041 was selected from the EST database for sequence similarity to DEK and SET proteins rearranged in leukemias. The ends of the cDNA were isolated by RACE technique. The assembled cDNA encodes an LRR-containing protein of 251 amino acids designated APRIL (acidic protein rich in leucines). APRIL has high similarity to human pp32, also named PHAPI (bovine I[PP2A]1), and to rat LANP, respectively. APRIL shows tissue-specific expression as shown by Northern blot analysis. It was localized to 15q25 by FISH.
Mencinger
M
M
Department of Clinical Genetics, University Hospital, Lund, Sweden. marina.mencinger@klingen.lu.se
Panagopoulos
I
I
Contreras
J A
JA
Mitelman
F
F
Aman
P
P
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D047390:Casein Kinase II; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051381:Rats; D014407:Tumor Cells, Cultured
C490341:ANP32B protein, human; C490338:Anp32a protein, rat; D009479:Neuropeptides; D009687:Nuclear Proteins; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases; D017868:Cyclic AMP-Dependent Protein Kinases