Structural aspects of monoamine oxidase and its reversible inhibition.
Among the various types of amine oxidases, monoamine oxidase (MAO) is of special interest for neuropsychiatry. It appears to play a central role in several psychiatric and neurological disorders, including clinical depression and Parkinson's Disease. The purpose of this paper is to review the major structural aspects of MAO, in relation with its primary sequence (site-directed mutagenesis, chimeric constructions), secondary and three-dimensional structures. The consequences of the inhibition of monoamine oxidase are considered, mainly focusing on the new generations of reversible and selective MAO inhibitors. Recent efforts to design and develop those inhibitors are emphasized and discussed.
Wouters
J
J
Facultes Universitaires Notre Dame de la Paix, Laboratoire de Chimie Moleculaire Structurale, 61, Rue de Bruxelles, B-5000 Namur, Belgium. wouters@scf.fundp.ac.be
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000737:chemistry* / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D016297:Mutagenesis, Site-Directed; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014337:Trout
D008996:Monoamine Oxidase Inhibitors; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; D008995:Monoamine Oxidase