Overview: hyperacute rt-PA stroke treatment. The NINDS rt-PA Stroke Study Group.
Ischemic stroke remains a significant problem in the United States. Complex intracellular metabolic events occur leading to cell death. A search for treatments to prevent this ischemic process continues. Thrombolytic agents, recently developed and tested, may lessen the disabling effects of stroke.
Donnarumma
R
R
Long Island Jewish Medical Center, Department of Neurology, New York, New York 11040, USA.
Kongable
G
G
Barch
C
C
Braimah
J
J
Bratina
P
P
Daley
S
S
Rapp
K
K
Sailor
S
S
Spilker
J
J
D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D006233:Persons with Disabilities; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D010960:Plasminogen Activators / Q000494:pharmacology / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D010959:Tissue Plasminogen Activator / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator