MRI visualization of focal induced neocortical malformations of the rat.
In an attempt to determine whether small focal malformations of the neocortex can be visualized in vivo, focal microgyria were induced in the neocortex of otherwise normal rats by freezing injury to the developing cortical plate, and in adulthood the malformation was visualized using MRI. Induced microgyria of varying size were successfully visualized with MRI, and the location and extent of the malformation was confirmed on subsequent histology. This work has potential implications for the field of experimental neuropathology by enhancing the ability to study the behavioral and connectional consequences of these malformations in animals. In addition, this work points toward future research for the in vivo visualization of these small, focal malformations in humans.
Rosen
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Dyslexia Research Laboratory and Charles A. Dana Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Burstein
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D000818:Animals; D002465:Cell Movement / Q000502:physiology; D005260:Female; D005615:Freezing; D008279:Magnetic Resonance Imaging; D019579:Neocortex / Q000002:abnormalities*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar