[Effect of superinhibitory levels of imipenem and amikacin singly or in combination on Pseudomonas aeruginosa].
Suppression of bacterial growth of a clinical Pseudomonas aeruginosa strain after 30 min treatment with imipenem and amikacin alone as well as after treatment with a combination of these antibiotics (postantibiotic effect-PAE) was studied. Imipenem (2xMIC) induced PAE lasting 0.7 h, at a concentration of 4xMIC caused suppression of bacterial growth for 1.5 h. The effect of suprainhibitory concentrations of amikacin was more substantial. Amikacin (2x or 4xMIC) manifested PAE of 1.9 h or 4.0 h. The postantibiotic effect induced by antibiotic combination-imipenem (2xMIC) + amikacin (2xMIC) (3.0 h) as well as imipenem (4xMIC) + amikacin (2xMIC) (4.0 h) was longer than the mathematical sum of the postantibiotic effects produced by individual antibiotics at the mentioned concentrations (2.6 h or 3.4 h). Prolongation of the suppression of bacterial growth induced by a combination of imipenem (2xMIC) + amikacin (2xMIC) was 15.4%, and 17.6% after treatment with a combination of imipenem (4xMIC) + amikacin (2xMIC).
Hostacká
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Ustav preventívnej a klinickej medicíny, Bratislava, Slovenská republika.
D000583:Amikacin / Q000008:administration & dosage / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D015378:Imipenem / Q000008:administration & dosage / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development*; D013845:Thienamycins / Q000008:administration & dosage / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem; D000583:Amikacin
Ucinok suprainhibicných koncentrácií imipenemu a amikacínu jednotlivo a úcinok ich kombinácie na Pseudomonas aeruginosa.