title: A comparative evaluation of the effect of pump type and heparin-coated surfaces on platelets during cardiopulmonary bypass.
abstract: Cardiopulmonary bypass (CPB) is associated with hemostatic disorders, mainly due to platelet function defects. In the present prospective study, platelet count and GMP-140 expression on platelets were investigated to comparatively evaluate the impact of different CPB-circuit systems on platelets. The study included 61 patients undergoing coronary artery bypass grafting, randomly assigned to 3 groups. In group A a roller pump, in group B a centrifugal pump, and in group C a centrifugal pump with a Carmeda heparin-coated CPB circuit was applied. Platelet count and GMP-140 expression were analysed pre, during, and following CPB. None of the tested CPB systems did affect platelet count. The percentage of GMP-140-positive platelets increased slightly early during CPB, whereas it decreased significantly postoperatively; group differences were observed between B and C after protamin administration. An advantage of the use of centrifugal pumps and heparin-coated circuits could not be proven with the present set-up. The results suggest that the benefit of the tested systems might depend on the operative procedure and management.
authors.affiliation: Department of Cardiothoracic Surgery, University Hospital, Würzburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Misoph
authors.forename: J
authors.initials: J
authors.lastname: Babin-Ebell
authors.forename: S
authors.initials: S
authors.lastname: Schwender
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage; D001792:Blood Platelets / Q000737:chemistry; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D001026:Coronary Artery Bypass; D005260:Female; D006355:Heart-Lung Machine; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation; D010976:Platelet Count
chemical_list: D000925:Anticoagulants; D019007:P-Selectin; D006493:Heparin