title: Association between high antistaphylolysin and teichoic acid antibody titres with rheumatic syndromes.
abstract: To analyse which rheumatic syndromes are associated with serological evidence of recent Staphylococcus aureus infection, we studied retrospectively 44 adult patients, gathered between 1979-1990, having an acute arthritis syndrome or an exacerbation in their chronic rheumatic disease and simultaneously a high antistaphylolysin (ASTA > 4,0) and/or high teichoic acid antibody titre (TAA > 8). Patients with septic arthritis or endoprosthetic infections were not included. 25 patients had arthritis/arthralgia associated with a known rheumatic disease, 9 patients had reactive arthritis and 8 patients had arthralgia. The frequency of HLA-B27 in tested patients was significantly higher in the whole patient group than in the healthy Finnish population (43% v 14%, p < 0.001). It is concluded that high ASTA and/or TAA titres are associated with various acute rheumatic syndromes including reactive arthritis.
authors.affiliation: Department of Medicine, Helsinki University Central Hospital, Finland.
authors.forename: J M
authors.initials: JM
authors.lastname: Valtonen
authors.forename: M T
authors.initials: MT
authors.lastname: Syrjälä
authors.forename: V V
authors.initials: VV
authors.lastname: Valtonen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000097:blood; D001168:Arthritis / Q000276:immunology; D001170:Arthritis, Infectious / Q000276:immunology; D016918:Arthritis, Reactive / Q000276:immunology; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006460:Hemolysin Proteins / Q000097:blood*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus; D013682:Teichoic Acids / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D015796:HLA-B27 Antigen; D006460:Hemolysin Proteins; D007136:Immunoglobulins; D013682:Teichoic Acids; C006603:antistaphylolysin