title: [Bufferin-induced lung injury manifesting as acute eosinophilic pneumonia].
abstract: A 26-year-old woman was admitted to our hospital because of dyspnea and fever one day after taking medicines for the common cold. A chest roentgenogram and a computed tomogram revealed diffuse patchy infiltrates in both lung fields. Examination of a specimen obtained by transbronchial lung biopsy showed thickening of alveolar walls and infiltration of eosinophils. Bronchoalveolar lavage fluid had many eosinophils. DLST was positive for Bufferin, which the patient took one day before the dyspnea and fever began. We believe that this patient's pulmonary disease was caused by Bufferin. We should realize that this widely used analgesic can cause acute eosinophilic lung disease. The patient was not given corticosteroids, and her condition improved soon after she stopped taking Bufferin.
authors.affiliation: Department of Respiratory Medicine, Showa General Hospital, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Shiota
authors.forename: Y
authors.initials: Y
authors.lastname: Nakaya
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: A
authors.initials: A
authors.lastname: Iwase
authors.forename: S
authors.initials: S
authors.lastname: Aoki
authors.forename: R
authors.initials: R
authors.lastname: Matsuoka
authors.forename: T
authors.initials: T
authors.lastname: Nagayama
authors.forename: Y
authors.initials: Y
authors.lastname: Kawabata
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D011657:Pulmonary Eosinophilia / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin