Early detection of cardiac damage with heart fatty acid-binding protein after cardiac operations.
BACKGROUND
It is still difficult to evaluate myocardial damage in the acute phase of reperfusion in cardiac operations. We investigated the clinical significance of human heart fatty acid-binding protein (HH-FABP) for detecting myocardial damage after cardiac operations earlier than creatine kinase MB isoform or troponin-T.


METHODS
Blood samples from 20 patients who underwent coronary artery bypass grafting were collected serially after reperfusion to measure serum levels of creatine kinase-MB, troponin-T, and HH-FABP.


RESULTS
Serum HH-FABP levels peaked earliest after reperfusion. In addition, the maximum serum HH-FABP level was predictable immediately after reperfusion. The maximum serum HH-FABP level correlated with the maximum serum creatine kinase-MB or troponin-T level, as well as with the aortic cross-clamp time or the maximum dose of catecholamines administered after reperfusion.


CONCLUSIONS
Measurements of HH-FABP allow for earlier evaluation of myocardial damage in the acute phase of reperfusion. Human heart fatty acid-binding protein may be a useful indicator of myocardial damage after cardiac operations.
Suzuki
K
K
First Department of Surgery, Osaka University, Suita, Japan.
Sawa
Y
Y
Kadoba
K
K
Takahashi
T
T
Ichikawa
H
H
Kagisaki
K
K
Ohata
T
T
Matsuda
H
H
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002352:Carrier Proteins / Q000097:blood*; D002395:Catecholamines / Q000008:administration & dosage; D001026:Coronary Artery Bypass / Q000009:adverse effects; D003402:Creatine Kinase / Q000097:blood; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D018996:Myelin P2 Protein / Q000097:blood*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis*; D009363:Neoplasm Proteins; D014336:Troponin / Q000097:blood; D025521:Tumor Suppressor Proteins
D015415:Biomarkers; D002352:Carrier Proteins; D002395:Catecholamines; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D007527:Isoenzymes; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D014336:Troponin; D025521:Tumor Suppressor Proteins; D003402:Creatine Kinase