A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyltransferase.
Aoyama
T
T
Drug Discovery Research Laboratory, Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd., Japan.
Satoh
T
T
Yonemoto
M
M
Shibata
J
J
Nonoshita
K
K
Arai
S
S
Kawakami
K
K
Iwasawa
Y
Y
Sano
H
H
Tanaka
K
K
Monden
Y
Y
Kodera
T
T
Arakawa
H
H
Suzuki-Takahashi
I
I
Kamei
T
T
Tomimoto
K
K
D016475:3T3 Cells; D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D051231:Farnesyltranstransferase; D005260:Female; D051379:Mice; D008819:Mice, Nude; D008956:Models, Chemical; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011106:Polyisoprenyl Phosphates / Q000737:chemistry* / Q000494:pharmacology; D012717:Sesquiterpenes; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011106:Polyisoprenyl Phosphates; D012717:Sesquiterpenes; C004808:farnesyl pyrophosphate; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase