title: Slow elimination of mannitol from human cerebrospinal fluid.
abstract: OBJECTIVE
  The rise of intracranial pressure above the pre-treatment level (rebound phenomenon) is considered, in part, a consequence of osmotherapeutics penetrating into the intracranial compartments.
  
  
  METHODS
  The kinetics of mannitol in the ventricular CSF were studied in 10 patients with cerebrovascular stroke after a single i.v. infusion of 37.5 g over 15 min.
  
  
  RESULTS
  Maximum mannitol CSF concentrations (mean = 51.1 mg.1-1) were reached 2-12 h after termination of the infusion. Mean t1/2CSF (18.3 h) by far exceeded t1/2S (3.71 h). AUCCSF/AUCS, as a measure of mannitol CSF penetration, ranged from 0.037 to 0.390.
  
  
  CONCLUSIONS
  The slow elimination of mannitol from CSF implies a high risk of accumulation in the central nervous compartments after repeated dosing.
authors.affiliation: Department of Neurology, University of Göttingen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Nau
authors.forename: H
authors.initials: H
authors.lastname: Desel
authors.forename: C
authors.initials: C
authors.lastname: Lassek
authors.forename: A
authors.initials: A
authors.lastname: Thiel
authors.forename: S
authors.initials: S
authors.lastname: Schinschke
authors.forename: R
authors.initials: R
authors.lastname: Rössing
authors.forename: H
authors.initials: H
authors.lastname: Kolenda
authors.forename: H W
authors.initials: HW
authors.lastname: Prange
mesh_terms: D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008353:Mannitol / Q000134:cerebrospinal fluid*; D008875:Middle Aged
chemical_list: D008353:Mannitol