title: Preoperative screening for lung volume reduction surgery: usefulness of combining thin-section CT with physiologic assessment.
abstract: OBJECTIVE
  This study was performed to assess the usefulness of preoperative thin-section CT alone and in combination with physiologic measurements in emphysema patients being evaluated for lung volume reduction surgery.
  
  
  METHODS
  Six 1-mm collimation sections through the chest were obtained in 20 patients being evaluated for lung volume reduction surgery. Extent and severity of emphysema were assessed by visually scoring the images. CT scores ranged from 0 to 144. Inspiratory resistance was measured in 12 of 20 patients and was also used to discriminate between responders (change in forced expiratory volume in 1 sec, > or = 150 ml after surgery) and nonresponders (change in forced expiratory volume in 1 sec, < 150 ml after surgery).
  
  
  RESULTS
  Four of 20 patients with mild emphysema as revealed by thin-section CT (scores of < 50) did not improve lung function after lung volume reduction surgery. Eight of the remaining 16 patients with moderate to severe emphysema as revealed by thin-section CT (scores of > 50) underwent inspiratory resistance measurement. Those seven patients whose inspiratory resistance measurement exceeded 8.5 cm H2O/l per second did not respond favorably to lung volume reduction surgery (change in forced expiratory volume in 1 sec, < 150 ml). The remaining five patients whose inspiratory resistance measurement was less than 8.5 cm H2O/l per second responded favorably to lung volume reduction surgery. Thus, only five of the 20 patients showed improvement in forced expiratory volume in 1 sec after surgery.
  
  
  CONCLUSIONS
  Our data suggest that among patients with moderate to severe emphysema who are being examined for lung volume reduction surgery, the combination of radiologic and physiologic assessment is more accurate for predicting a favorable response to lung volume reduction surgery than radiologic assessment alone. However, in patients with chronic obstructive pulmonary disease by the American Thoracic Society criteria, mild emphysema as revealed on thin-section CT virtually precludes further workup because these patients are unlikely to respond favorably to lung volume reduction surgery.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: A
authors.initials: A
authors.lastname: Hunsaker
authors.forename: E
authors.initials: E
authors.lastname: Ingenito
authors.forename: U
authors.initials: U
authors.lastname: Topal
authors.forename: R
authors.initials: R
authors.lastname: Pugatch
authors.forename: J
authors.initials: J
authors.lastname: Reilly
mesh_terms: D000328:Adult; D000368:Aged; D000403:Airway Resistance; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011013:Pneumonectomy; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011656:Pulmonary Emphysema / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery*; D012680:Sensitivity and Specificity; D013147:Spirometry; D014057:Tomography, X-Ray Computed