title: Surgery in the management of small cell lung cancer.
abstract: OBJECTIVE
  We analyzed our experience in the period January 1975-December 1995 aiming to confirm the role of surgery in the multimodality treatment of small cell lung cancer (SCLC).
  
  
  METHODS
  127 patients (5.28% of the overall lung resections for carcinoma) underwent surgery for SCLC. The median age was 60 years (range 34-73). In 87 patients (68.5%) a pre-operative tissue diagnosis was effected and those patients underwent a complete staging procedure. Fifteen patients received up to six complete courses of neoadjuvant and adjuvant chemotherapy. The surgical procedures included: 50 pneumonectomies, 71 lobectomies and six wedge resections. Two patients experienced a local recurrence and a completion pneumonectomy was performed.
  
  
  RESULTS
  The median follow-up is 66 months (range 6-214). The 5-year actuarial survival rate is 22.6% (median 18 months). Twenty-three patients are still alive, 21 of them being disease-free. Considering the most conspicuous group of patients (n = 92) treated by surgery and adjuvant chemotherapy, the survival data were 47.2, 14.8 and 14.4% for Stage I, II and III, respectively (P = 0.001). NO patients had a significantly better survival than N1 and N2 patients (P = 0.035).
  
  
  CONCLUSIONS
  Surgery and adjuvant chemotherapy might represent an effective form of treatment of limited SCLC without lymph-node involvement. The role of surgery is yet to be verified as regards N1 and N2 status, where even neoadjuvant chemotherapy has not achieved the hoped-for results (no patient reaching a 2-year survival).
authors.affiliation: Service of Thoracic Surgery, Department of Surgery, University of Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Lucchi
authors.forename: A
authors.initials: A
authors.lastname: Mussi
authors.forename: A
authors.initials: A
authors.lastname: Chella
authors.forename: A
authors.initials: A
authors.lastname: Janni
authors.forename: A
authors.initials: A
authors.lastname: Ribechini
authors.forename: G F
authors.initials: GF
authors.lastname: Menconi
authors.forename: C A
authors.initials: CA
authors.lastname: Angeletti
mesh_terms: D000328:Adult; D000368:Aged; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011013:Pneumonectomy; D015996:Survival Rate