title: Vitamin B-6 requirement and status assessment of young women fed a high-protein diet with various levels of vitamin B-6.
abstract: The vitamin B-6 requirement of young women consuming a constant high-protein diet (1.55 g/kg body wt) and the effect of various ratios of vitamin B-6 to protein on this requirement were studied. Eight women were fed a lactoovovegetarian basal diet containing 0.45 mg vitamin B-6 (2.66 micromol as pyridoxine) and 30 micromol carnitine for 92 d. The protocol consisted of successive baseline adjustment (9 d), depletion (27 d), and repletion (two 21-d and then one 14-d) periods. Vitamin B-6 intakes were 1.60, 0.45, 1.26, 1.66, and 2.06 mg, resulting in ratios of vitamin B-6 (in mg) to protein (in g) for the five periods of 0.016, 0.005, 0.013, 0.017, and 0.021, respectively. Direct and indirect as well as short- and long-term vitamin B-6 status measures were assessed weekly. Regression analysis revealed that the amount of dietary vitamin B-6 required to normalize urinary 4-pyridoxic acid, plasma pyridoxal-P, erythrocyte pyridoxal-P and pyridoxal, and erythrocyte alanine and aspartate aminotransferase activity coefficients to predepletion baseline values was 1.94 mg vitamin B-6/d (0.019 mg vitamin B-6/g protein). This study suggests that the current vitamin B-6 recommended dietary allowance of 1.6 mg/d based on 0.016 mg/g protein is not an adequate intake and may require reevaluation.
authors.affiliation: Department of Food Science and Human Nutrition, Washington State University, Pullman 99164-6376, USA.
authors.forename: Y C
authors.initials: YC
authors.lastname: Huang
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: M A
authors.initials: MA
authors.lastname: Evans
authors.forename: M E
authors.initials: ME
authors.lastname: Mitchell
authors.forename: T D
authors.initials: TD
authors.lastname: Shultz
mesh_terms: D000328:Adult; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D006801:Humans; D016014:Linear Models; D015596:Nutrition Assessment; D018673:Nutrition Policy; D009751:Nutritional Requirements; D011735:Pyridoxic Acid / Q000652:urine; D011736:Pyridoxine / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism
chemical_list: D004044:Dietary Proteins; D011735:Pyridoxic Acid; D011736:Pyridoxine