title: The biological role of haptoglobin and behaviour of this protein in different diseases, with special attention paid to brain stroke.
abstract: Haptoglobin (Hp) is an alpha 2 glycoprotein, the presence of which was determined in blood serum in 1940 by Polonovski and Jayle. Smithies showed genetically conditioned polymorphism of haptoglobin (4, 16). Molecular heterogeneity of haptoglobin is demonstrated by three main phenotypes: Hp 1-1, Hp 2-2, Hp 2-1. Haptoglobin is a glycoprotein with tetrametric structure. Haptoglobin 1-1 is composed of two alpha (light) chains with 9,000 molecular mass including 83 amino acids and two beta (heavy) chains with 40,000 molecular mass including 245 amino acids. Alpha chains are connected with each other by two sulfurous bonds which also connect alpha chains with beta chains (3, 4).
authors.affiliation: Katedra i Klinika Neurologii Akademii Medycznej w Lublinie.
authors.forename: J
authors.initials: J
authors.lastname: Iłzecka
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000378:metabolism*; D005786:Gene Expression Regulation; D006242:Haptoglobins / Q000378:metabolism*; D006801:Humans; D017665:Hydroxyl Radical / Q000378:metabolism; D002546:Ischemic Attack, Transient / Q000378:metabolism; D008099:Liver / Q000378:metabolism
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D017665:Hydroxyl Radical