Identification of a high concentration of scyllo-inositol in the brain of a healthy human subject using 1H- and 13C-NMR.
The peak at 3.35 ppm in the 1H-NMR spectrum characteristic for scyllo-inositol may be a marker for cerebral pathology, although it has a well-known constant concentration relative to myo-inositol. Such a peak was observed with an intensity at least 300% above normal in the brain of a healthy volunteer. The scyllo-inositol signal was assigned based on the detection of a corresponding peak at 74.5 ppm in the 13C-NMR spectrum and on the demonstration of singlet characteristics of the proton signal. The presence of substantial brain concentrations of scyllo-inositol suggests that scyllo-inositol metabolism may be regulated independently from myo-inositol and that such concentrations are compatible with normal health.
Seaquist
E R
ER
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA.
Gruetter
R
R
D000328:Adult; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013237:Stereoisomerism
C009217:scyllitol; D007294:Inositol