Structural insights into DNA polymerase beta fidelity: hold tight if you want it right.
DNA polymerases must select and incorporate the correct deoxynucleoside 5'-triphosphate from a pool of structurally similar molecules. The structural and kinetic characterization of DNA polymerase beta indicates that this polymerase must stabilize the templating base to achieve efficient polymerization with high fidelity.
Beard
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Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Wilson
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D001665:Binding Sites; D018360:Crystallography, X-Ray; D004247:DNA / Q000096:biosynthesis; D019951:DNA Polymerase beta / Q000737:chemistry* / Q000378:metabolism; D004261:DNA Replication; D003854:Deoxyribonucleotides / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation
D003854:Deoxyribonucleotides; D004247:DNA; D019951:DNA Polymerase beta