title: IgG antineutrophil cytoplasmic antibodies in IgA nephropathy: a clinical variant?
abstract: Anti-neutrophil cytoplasmic antibodies (ANCAs) of the immunoglobulin (Ig) G isotype are associated with rapidly progressive glomerulonephritis. These have been detected rarely in patients with Henoch-Schönlein purpura (HSP) and have only been previously reported once in a patient with IgA nephropathy (IgAN). In contrast, IgA-ANCAs have been detected in patients with HSP or IgAN, although further verification of this finding by various investigators has yielded conflicting results. We report a case of biopsy-proven IgAN in which the patient developed a rapidly progressive glomerulonephritis and was determined to have ANCAs of both IgA and IgG isotypes. This report suggests an association between fulminant IgAN and ANCA-associated disease and that ANCAs may be underdetected in children with previously diagnosed IgAN. Identification of these antibodies may guide further management of these patients.
authors.affiliation: Division of Nephrology, Children's Hospital, Boston, MA 02115, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Ramirez
authors.forename: S
authors.initials: S
authors.lastname: Rosen
authors.forename: J
authors.initials: J
authors.lastname: Niles
authors.forename: M J
authors.initials: MJ
authors.lastname: Somers
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D002648:Child; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007668:Kidney / Q000473:pathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007070:Immunoglobulin A