[In vitro peroxidation of plasma and erythrocyte lipids during WR-1339 induced hyperlipidemia in Wistar rats].
The inhibition of lipoprotein catabolism after triton WR-1339 intravenous administration is associated with an impressive modification in the balance between plasma peroxidable substrates and antioxidants. Treated rat plasma and membrane lipids become peroxiaable when they are incubated with phenylhydrazine in standardized conditions and the production of thiobarbituric acid-reactive substances (lipoperoxidation markers) significantly increases. An accumulation of native lipoproteins which present a decreased alpha-tocopherol on triglycerid ratio and a modification in the plasmatic balance between alpha-tocopherol and ascorbate could explain these observations.
Zimmermann
L
L
Service Pharmacie, Hôpital Joffre, Draveil.
Antébi
H
H
Morvan-Bourcier
C
C
Alcindor
L G
LG
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000737:chemistry; D005227:Fatty Acids / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000139:chemically induced; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013501:Surface-Active Agents / Q000494:pharmacology*; D014810:Vitamin E / Q000097:blood
D005227:Fatty Acids; D008055:Lipids; D013501:Surface-Active Agents; D014810:Vitamin E; D011092:Polyethylene Glycols; D001205:Ascorbic Acid; C016811:tyloxapol
Peroxydation in vitro des lipides plasmatiques et érythrocytaires au cours de l'hyperlipémie post-triton WR-1339 chez le rat Wistar.