Neurochemical abnormalities in Alzheimer's disease and Parkinson's disease--a comparative review.
We report a meta-analysis of the brain neurochemical abnormalities in Alzheimer's (AD) and Parkinson's disease (PD). Evidence for oxidative stress, and disorders of energy metabolism and excitatory amino acids is presented for both disorders. However, limited data and conflicting findings preclude any definitive statement relating to differences and overlap between the two conditions.
Gsell
W
W
Department of Psychiatry, Clinical Neurochemistry, University of Würzburg, Federal Republic of Germany.
Strein
I
I
Krause
U
U
Riederer
P
P
D000544:Alzheimer Disease / Q000378:metabolism*; D001923:Brain Chemistry / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D018846:Excitatory Amino Acids / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000378:metabolism*
D018846:Excitatory Amino Acids