Allotypes and gynecological cancer.
OBJECTIVE
To investigate if gynecologic cancer patients have different immune responses.


METHODS
Immunoglobulin heavy chains (Glm, G3m), Kappa light chains (Km) and allotype and phenotype frequencies were examined in 58 patients with gynecologic cancer (ovarian, cervical, endometrial, vulval, vaginal and uterine sarcoma) and a control group of 26 women.


RESULTS
No significant differences were found between the different allotype of phenotype frequencies between the two groups.


CONCLUSIONS
Our results indicate that Gm and Km allotypes do not represent susceptibility factors for gynecologic cancer in Caucasians.
Hitoglou-Hadji
S
S
Laboratory of General Biology, Aristotelian University of Thessaloniki, Greece.
Makedos
G
G
Papanicolaou
A
A
Dozi-Vasiliadou
I
I
D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000276:immunology; D005260:Female; D005833:Genital Neoplasms, Female / Q000145:classification / Q000276:immunology*; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000276:immunology; D010641:Phenotype; D012016:Reference Values; D002583:Uterine Cervical Neoplasms / Q000276:immunology; D014594:Uterine Neoplasms / Q000276:immunology; D014625:Vaginal Neoplasms / Q000276:immunology; D014846:Vulvar Neoplasms / Q000276:immunology
D015415:Biomarkers; D007129:Immunoglobulin Gm Allotypes