title: [Morphological study of the liver of mice-like rodents from areas of the Altai region exposed to radioactive pollution].
abstract: Morphofunctional liver state of two mice-like rodents species caught at the three areas of Altai region exposed to radiation during nuclear tests at Semipalatinsk site was studied. It was shown that the stereotype morphofunctional changes in the liver of both rodent species were developed under chronic influence of low doses of radiation and chemical contamination. These changes are manifested as dystrophic disorders of hepatocytes and hemodynamic disturbances accompanied by a decrease of volume ratio of sinusoidal capillaries to hepatocytes and stroma to parenchyma. Hyperglycogenosis, redistribution of the main cytoplasmic organelles, and considerably reduction of the volume densities of mitochondria, smooth and rough endoplasmic reticulum are the leading ultrastructural changes. Moreover, character and manifestation of the changes are determined by ecological belonging and correlated with intensity of anthropogenic pollution. The role of these changes in development of long-term pathology are discussed.
authors.affiliation: Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: O P
authors.initials: OP
authors.lastname: Molodykh
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomniashchikh
mesh_terms: D000818:Animals; D003411:Arvicolinae; D003627:Data Interpretation, Statistical; D004463:Ecology; D008099:Liver / Q000378:metabolism / Q000528:radiation effects* / Q000648:ultrastructure; D008112:Liver Glycogen / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism / Q000528:radiation effects; D009689:Nuclear Warfare; D015388:Organelles / Q000378:metabolism / Q000528:radiation effects; D011847:Radioactive Fallout; D012800:Siberia
chemical_list: D008112:Liver Glycogen; D011847:Radioactive Fallout
vernacular_title: Morfologicheskoe issledovanie pecheni myshevidnykh gryzunov iz raĭonov Altaĭskogo kraia, podvergnutykh radiatsionnomu zagriazneniiu.