A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13.
We performed a genome-wide linkage analysis search for a genetic locus responsible for kidney dysfunction in a large family. This inherited condition, characterized by proteinuria, progressive renal insufficiency, and focal segmental glomerulosclerosis, follows autosomal dominant inheritance. We show with a high degree of certainty (maximum 2-point lod score 12.28) that the gene responsible for this condition is located on chromosome 19q13.
Mathis
B J
BJ
Department of Medicine, Oklahoma State University College of Osteopathic Medicine, Tulsa, USA.
Kim
S H
SH
Calabrese
K
K
Haas
M
M
Seidman
J G
JG
Seidman
C E
CE
Pollak
M R
MR
D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005192:Family Health; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics* / Q000473:pathology; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree