A method for measuring capillary bleeding time in non-anaesthetized dogs: prolongation of the bleeding time by acetylsalicylic acid.
A reproducible standardized method for measuring capillary bleeding time (CBT) in dogs is presented. The skin was punctured at the toe from a forelimb of non-anaesthetized dogs parallel to the edge of the horny skin of the pad. Before the procedure, a cuff of a sphygmometer was placed above the antibrachium and a hyperaemie agent was applied to the shaved area. The normal CBT in non-anaesthetized dogs was 2.25 +/- 0.76 min (x +/- SD). After injection of acetylsalicylic acid (ASA) (20 mg/kg body weight), CBT was prolonged up to 25 min. Platelet aggregation in response to 10 micrograms collagen/ml was decreased in parallel after treatment with ASA.
Nolte
I
I
Hanover School of Veterinary Medicine, Clinic of Small Animals, Germany.
Niemann
C
C
Bowry
S K
SK
Failing
K
K
Müller-Berghaus
G
G
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001760:Bleeding Time / Q000662:veterinary; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D001780:Blood Coagulation Tests / Q000379:methods / Q000662:veterinary*; D004285:Dogs / Q000097:blood* / Q000502:physiology; D015203:Reproducibility of Results; D012867:Skin / Q000098:blood supply
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin