Body-fundic gastric ulcer and Helicobacter pylori: muco-peptic cells expansion (immature cells) in Helicobacter pylori positive patients.
It is generally agreed that Helicobacter pylori (Hp) plays a key role in alterating regulatory factors affecting cellular proliferation during the disease process. During chronic superficial gastritis there is, in case of moderate/severe activity, a foveolar-superficial expansion of immature muco-peptic cells. In the present experience this phenomenon has been evaluated in the surrounding areas of 22 body-fundic gastric ulcer (BFGU). The 72.7% of BFGU were Hp positive. The expansion was detectable in 68.7% of Hp positive BFGU. The expansion process involves the substitution of mature cells with immature one determining a reduction of the efficacy of the mucosa barrier in association with an increment of aggressive factors (mucosal pepsins). This phenomenon in relation with host genetic susceptibility may favor peptic ulcer.
Testino
G
G
Department of Gastroenterology and Digestive Endoscopy, S. Martino Hospital, Genova, Italy.
Testino
R
R
D002455:Cell Division; D016009:Chi-Square Distribution; D005260:Female; D005748:Gastric Fundus / Q000378:metabolism / Q000473:pathology; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000382:microbiology / Q000473:pathology*