title: Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vgamma9/Vdelta2 T cells in tumor immunity.
abstract: The Vgamma9/Vdelta2 T cell receptor (TCR) is expressed by most human gammadelta T cells. We show here that cytotoxic T lymphocytes of the Vgamma9/Vdelta2 subset, but not of the Vdelta1 subset of human gammadelta T cells, express natural killer inhibitory receptors (KIR) with specificity for different HLA class I alleles that down-regulate TCR-mediated signaling in response to HLA class I-expressing B cell lymphomas. Vgamma9/Vdelta2 T cell clones with a T helper cell phenotype lack KIR and produce lymphokines in response to most human B cell lymphomas, just as they do upon recognition of the HLA class I-deficient human Burkitt's lymphoma Daudi. Thus, human Vgamma9/Vdelta2 T cells have an innate specificity for nonpolymorphic cell surface structures expressed by many lymphoma cells and their cytotoxic activity is controlled by KIR. These results imply a general role of human Vgamma9/Vdelta2 T cells in the defense against hematopoietic tumors that is distinct from NK cells.
authors.affiliation: Department of Immunology, University of Tübingen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Fisch
authors.forename: E
authors.initials: E
authors.lastname: Meuer
authors.forename: D
authors.initials: D
authors.lastname: Pende
authors.forename: S
authors.initials: S
authors.lastname: Rothenfusser
authors.forename: O
authors.initials: O
authors.lastname: Viale
authors.forename: S
authors.initials: S
authors.lastname: Kock
authors.forename: S
authors.initials: S
authors.lastname: Ferrone
authors.forename: D
authors.initials: D
authors.lastname: Fradelizi
authors.forename: G
authors.initials: G
authors.lastname: Klein
authors.forename: L
authors.initials: L
authors.lastname: Moretta
authors.forename: H G
authors.initials: HG
authors.lastname: Rammensee
authors.forename: T
authors.initials: T
authors.lastname: Boon
authors.forename: P
authors.initials: P
authors.lastname: Coulie
authors.forename: P
authors.initials: P
authors.lastname: van der Bruggen
mesh_terms: D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta; D011971:Receptors, Immunologic