title: Aneurysms of sinus of Valsalva eroding into the interventricular septum: etiopathology and surgical considerations.
abstract: OBJECTIVE
  To evaluate and discuss etiopathology, clinical manifestations and surgical outcome of a rare subset of unruptured aneurysm of the sinus of Valsalva which erodes into the interventricular septum.
  
  
  METHODS
  Between 1989 and 1995, seven cases of unruptured aneurysm of the sinus of Valsalva eroding into the interventricular septum underwent surgical correction at the King Edward VII Memorial Hospital, Bombay. The origin of all these aneurysms was from the right coronary sinus. The mean age of presentation was 31 years. All patients were male. Calcification of the aneurysm was seen in three. Three patients presented without aortic regurgitation; all had complete heart block. Four patients presented with aortic regurgitation and in addition, two had complete heart block. Preoperative left ventricular function was poor in patients with aortic regurgitation (Ejection fraction range; 30-42%), when compared to those without aortic regurgitation (Ejection fraction range; 48-52%). Of those without aortic regurgitation at initial presentation, one patient developed progressive aortic regurgitation after 3 years requiring surgery. While two other patients were operated at earliest for closure of aneurysm, even in the absence of aortic regurgitation. All those with aortic regurgitation required surgery for aortic valve replacement and closure of aneurysm. Aneurysm was closed by direct suturing of the ostium in two patients and by patch closure in five patients. Permanent pacemaker was implanted in five patients.
  
  
  RESULTS
  There was no operative death. Patients who underwent aortic valve replacement required postoperative ionotropic support. Two patients, who underwent surgery in absence of aortic regurgitation, remain free of aortic regurgitation at the end of 36 and 42 months of follow-up. One of the patients with calcific aneurysmal sac underwent successful re-replacement of the aortic valve for paravalvar leak after a 2 year interval.
  
  
  CONCLUSIONS
  Unruptured aneurysm of the sinus of Valsalva eroding into the interventricular septum should be operated at the earliest, which makes surgery simple and prevents development of complications such as aortic regurgitation and heart block.
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, King Edward VII Memorial Hospital, Parel, Bombay, India. manesh.patel@arthurandersen.com
authors.forename: V N
authors.initials: VN
authors.lastname: Bapat
authors.forename: A G
authors.initials: AG
authors.lastname: Tendolkar
authors.forename: J
authors.initials: J
authors.lastname: Khandeparkar
authors.forename: B
authors.initials: B
authors.lastname: Dalvi
authors.forename: N
authors.initials: N
authors.lastname: Agrawal
authors.forename: H
authors.initials: H
authors.lastname: Kulkarni
authors.forename: R
authors.initials: R
authors.lastname: Magotra
mesh_terms: D000328:Adult; D001014:Aortic Aneurysm / Q000150:complications / Q000209:etiology / Q000473:pathology* / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000209:etiology; D002114:Calcinosis / Q000473:pathology; D006327:Heart Block / Q000209:etiology; D006346:Heart Septum / Q000473:pathology; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D012086:Reoperation; D012850:Sinus of Valsalva; D013318:Stroke Volume; D016896:Treatment Outcome