Mechanistic modeling of multiple tumorigenesis: an application to data on lung tumors in mice exposed to urethane.
This paper discusses an application of the stochastic model of carcinogenesis proposed by Yakovlev and Polig to the analysis of experimental data on multiple pulmonary tumors induced by urethane. The results of this analysis suggest that the rate of administration of urethane has no effect on the mean number of initiated cells per unit dose. Likewise, the formation of lesions responsible for cell death appears to be unaffected by the dose rate.
Yakovlev
A Y
AY
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City 84108, USA. yak@genetics.utah.edu
Pavlova
L V
LV
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D004195:Disease Models, Animal; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D008805:Mice, Inbred A; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced; D013269:Stochastic Processes; D014520:Urethane / Q000633:toxicity*
D014520:Urethane