The use of heparinase to neutralize residual heparin in blood samples drawn through pediatric indwelling central venous catheters.
Routine-coagulation screening is unreliable if obtained through a previously heparinized central venous catheter. Screening tests were performed on 14 paired peripheral and central venous catheter samples without and with heparinase. The heparinase treated central venous catheter samples correlated well with the peripheral samples and can be used to atraumatically screen for hemostatic abnormalities.
Keller
F G
FG
Department of Pediatrics, West Virginia University School of Medicine, Morgantown 26506-9214, USA.
DeFazio
J
J
Jencks
F
F
Steiner
M
M
Rogers
J
J
Ritchey
A K
AK
D000293:Adolescent; D001780:Blood Coagulation Tests; D002405:Catheterization, Central Venous; D002406:Catheterization, Peripheral; D002408:Catheters, Indwelling; D002648:Child; D004866:Equipment Contamination; D006487:Hemostasis; D006493:Heparin / Q000097:blood*; D019763:Heparin Lyase; D006801:Humans
D006493:Heparin; D019763:Heparin Lyase