title: Purine and nucleoside metabolites from the Antarctic sponge Isodictya erinacea.
abstract: The bright yellow sponge Isodictya erinacea is one of several chemically defended sponges found on the benthos of McMurdo Sound, Antarctica. An investigation of the metabolites from this sponge has resulted in the isolation of purine and nucleoside metabolites, including the previously unreported erinacean (1) and p-hydroxybenzaldehyde. The latter metabolite has been demonstrated to cause a feeding deterrence behavior in Perknaster fuscus, the major predator of antarctic sponges.
authors.affiliation: Department of Chemistry, Florida Institute of Technology, Melbourne 32901, USA.
authors.forename: B
authors.initials: B
authors.lastname: Moon
authors.forename: B J
authors.initials: BJ
authors.lastname: Baker
authors.forename: J B
authors.initials: JB
authors.lastname: McClintock
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000378:metabolism*; D011687:Purines / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013215:Starfish; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D009705:Nucleosides; D011687:Purines