[Immunologic characteristics of women recurrent spontaneous abortion of unknown etiology. II. Characterization of humoral immunology].
The purpose of this study was to analyze the humoral immune response of non-pregnant women with unexplained recurrent spontaneous abortion (RSA). The study group was consisted of 117 nonpregnant women with RSA and 44 healthy, non-pregnant multigravidas (as a control). The following immunological parameters were analyzed in peripheral blood of two groups of women: the effect of autologous sera on proliferation of lymphocytes stimulated with phytohemagglutinin (PHA) or paternal lymphocytes (in mixed lymphocyte reaction--MLR), incidence of MLR-blocking antibodies (MLR-BAbs) incidence of antinuclear and anticardiolipin antibodies. The results show that women with RSA of unknown etiology differ in some parameters of immune response--higher incidence of antinuclear and anticardiolipin antibodies, absence of serum factors suppressing lymphocyte proliferation in response to PHA and paternal alloantigens--in comparison with nonpregnant normal multigravidas.
Malinowski
A
A
Katedry Połoznictwa i Ginekologii WAM, Centrum Zdrowia Matki Polki.
Zeman
K
K
Wilczyński
J
J
Głowacka
E
E
Banasik
M
M
Powierza
S
S
Pokoca
L
L
Szpakowski
M
M
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D000974:Antibodies, Antinuclear / Q000032:analysis; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000032:analysis; D010298:Parity; D011247:Pregnancy; D012008:Recurrence
D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D007519:Isoantigens
Immunologiczne odrebności kobiet z poronieniami nawykowymi o niewyjaśnionej etiologii. II. Charakterystyka stanu odporności humoralnej.