title: Myocardial clearance of I-123 metaiodobenzylguanidine in dilated cardiomyopathy.
abstract: We present the results of sequential imaging studies conducted in two patients with dilated cardiomyopathy whose responses to long-term beta-blocker therapy differed. We evaluated the time course of the myocardial clearance and the heart to upper mediastinal ratios of I-123 metaiodobenzylguanidine (MIBG) scintigraphy. In the first patient, the left ventricular ejection fraction as well as the clinical symptoms were improved by long-term beta-blocker therapy with a concurrent normalization of the myocardial clearance and the heart to upper mediastinal ratio of I-123 MIBG scintigraphy. The myocardial clearance and the upper mediastinal ratio of I-123 MIBG indicated no improvement in the second patient, and the left ventricular function did not change. The myocardial clearance and the heart to upper mediastinal ratio of I-123 MIBG scintigraphy were useful in evaluating the efficacy of long-term beta-blocker therapy in patients with dilated cardiomyopathy.
authors.affiliation: Department of Cardiovascular Medicine, Okayama University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamanari
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: S
authors.initials: S
authors.lastname: Takenaka
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Koyama
authors.forename: T
authors.initials: T
authors.lastname: Ohe
mesh_terms: D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000378:metabolism; D015902:Gamma Cameras; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine