[Various reactions of sevoflurane with the individual components of soda lime].
The various components of commercial soda lime (sodium hydroxide, potassium hydroxide, calcium hydroxide, barium hydroxide) were studied in terms of their reactivity with sevoflurane at its boiling point (59 degrees C). A simple closed system, a reflux cooler, served as a model. Analyses were performed by GC/MS. Besides sevoflurane, we identified four compounds: A, B, C, and D. Free methanol, formaldehyde and formic acid could not be found. Presumably methanol is transferred from an intermediate formalin-semiacetal of the hexafluorisopropanol. Calcium hydroxide and barium hydroxide showed little reaction with sevoflurane, whereas larger amounts of reaction products were observed with sodium hydroxide and potassium hydroxide. The alkali hydroxides of sodalime are presumably responsible for its reaction with halogenated inhalation anaesthetics. We therefore conclude that decomposing reactions of halogenated inhalation anesthetics with dry soda lime could be prevented by using a newly developed soda lime.
Förster
H
H
Zentrum der Anaesthesiologie und Wiederbelebung, Klinkum der Johann-Wolfgang-Goethe-Universität Frankfurt am Main.
Warnken
U H
UH
Asskali
F
F
D018685:Anesthetics, Inhalation / Q000737:chemistry*; D017609:Barium Compounds / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry*; D002126:Calcium Hydroxide / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006878:Hydroxides / Q000737:chemistry; D008738:Methyl Ethers / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D017680:Potassium Compounds / Q000737:chemistry; D000077149:Sevoflurane; D012972:Sodium Hydroxide / Q000737:chemistry*
D018685:Anesthetics, Inhalation; D017609:Barium Compounds; D017610:Calcium Compounds; D006878:Hydroxides; D008738:Methyl Ethers; D010087:Oxides; D017680:Potassium Compounds; C012766:barium hydroxide; D000077149:Sevoflurane; C004569:soda lime; D012972:Sodium Hydroxide; D002126:Calcium Hydroxide; C029943:potassium hydroxide
Unterschiedliche Reaktion von Sevofluran mit einzelnen Komponenten von Atemkalk.