[Bronchial hyperresponsiveness in patients with vasospastic angina pectoris (VSAP)].
To determine the relationship between airway and coronary artery spasmogenesity in patients with vasospastic angina pectoris (VSAP), we measured the bronchial responsiveness to inhaled methacholine in 21 VSAP patients (V-group) and compared it to that of 17 chest pain syndrome patients with normal coronary (N-group). In the V-group, logarithmic values of the minimum cumulative dose required to decrease respiratory conductance from the baseline (Log Dmin) was significantly lower than that in N-group (0.47 +/- 0.60 log units vs. 0.98 +/- 0.60 log units respectively, p < 0.05). Log Dmin was significantly correlated with the dose of acetylcholine which induced a greater than 90% stenosis of the coronary artery (r = 0.383, p < 0.05). We concluded that both the coronary artery and the airway show hyperresponsiveness to cholinergic agonists in patients with VSAP.
Kageshita
T
T
Department of Respiratory Disease, Takatsuki General Hospital, Osaka, Japan.
Nishimura
Y
Y
Nakata
H
H
Terashima
M
M
Kajiura
T
T
Maeda
H
H
Yokoyama
M
M
D000368:Aged; D000787:Angina Pectoris / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D003329:Coronary Vasospasm / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged
D016210:Methacholine Chloride