title: Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden).
abstract: Bilateral renal vein thrombosis and venous sinus thrombosis were diagnosed within 3 weeks of birth in a full-term neonate. Heterozygosity for a factor V mutation leading to resistance against the anticoagulatory properties of activated protein C was found. Heparin therapy led to resolution of the thrombotic manifestations. With long-term oral anticoagulation, no relapse or other thrombotic event occurred during infancy.
authors.affiliation: University Children's Hospital, Albert-Ludwig University, Freiburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Pohl
authors.forename: L B
authors.initials: LB
authors.lastname: Zimmerhackl
authors.forename: F
authors.initials: F
authors.lastname: Heinen
authors.forename: A H
authors.initials: AH
authors.lastname: Sutor
authors.forename: R
authors.initials: R
authors.lastname: Schneppenheim
authors.forename: M
authors.initials: M
authors.lastname: Brandis
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D006493:Heparin / Q000627:therapeutic use; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D002542:Intracranial Embolism and Thrombosis / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D009154:Mutation; D012082:Renal Veins; D013927:Thrombosis / Q000150:complications / Q000188:drug therapy / Q000235:genetics*
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V; D006493:Heparin