Stimulation of IL-2 production and CD2R expression by splenopentin analogs.
Splenopentin (SP-5), is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin. Its synthetic analogs: Lys-Lys-Glu-Val-Tyr(1) and D-Lys-Lys-Glu-Val-Tyr (2) have been evaluated for active T-cell rosette (CD2R), total T-cell rosette (CD2), interleukin-2 (IL-2) stimulation and effect on antibody production. SP-5 as well as both the analogs stimulated CD2R. Analogs (1) and (2) were also found to stimulate IL-2 production. These observations suggest that in vitro human NK cell augmentation with analogs (1) and (2) reported earlier may be due to enhanced IL-2 production.
Biswas
S
S
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Singh
V K
VK
Rastogi
A
A
Sharan
R
R
Haq
W
W
Mathur
K B
KB
Agarwal
S S
SS
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D018801:CD2 Antigens / Q000096:biosynthesis*; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D010446:Peptide Fragments / Q000494:pharmacology*; D012397:Rosette Formation; D013268:Stimulation, Chemical; D013946:Thymopoietins / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects
D000276:Adjuvants, Immunologic; D018801:CD2 Antigens; D007376:Interleukin-2; D010446:Peptide Fragments; D013946:Thymopoietins; C041898:splenopentin