Can cervical dysplasia and cancer be prevented with nutrients?
Invasive cervical cancer accounts for 11.6% of all cancers worldwide and is the second most common cancer among women. It is the most common cancer among women living in less developed countries. Although infection with oncogenic-type human papillomaviruses (HPV) is associated with most cases of cervical cancer, HPV infection alone is an insufficient cause of cervical cancer. Research from the last two decades suggests a role for nutrients in the prevention of cervical cancer. However, results from phase III folic acid and beta-carotene chemoprevention trials have been negative. Potential reasons for the lack of treatment effect are discussed within the context of cervical carcinogenesis.
Giuliano
A R
AR
Arizona Prevention Center, University of Arizona, Tucson 85724, USA.
Gapstur
S
S
D019587:Dietary Supplements; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage* / Q000627:therapeutic use; D002578:Uterine Cervical Dysplasia / Q000178:diet therapy / Q000517:prevention & control*; D002583:Uterine Cervical Neoplasms / Q000178:diet therapy / Q000517:prevention & control*; D019207:beta Carotene / Q000008:administration & dosage* / Q000627:therapeutic use
D019207:beta Carotene; D014212:Tretinoin; D005492:Folic Acid