Unsuspected uterine leiomyosarcoma discovered during treatment with a gonadotropin-releasing hormone analogue: a case report and literature review.
We report a case of a 37-year-old woman who had received five courses of gonadotropin-releasing hormone (GnRH) agonist (Decapeptyl) for presumed uterine leiomyomata associated with episodes of uterine bleeding. Submucous myoma (histologically proven) was partially removed on the first visit. After a period of significant reduction in the tumor size and cessation of uterine bleeding, the symptoms recurred along with rapid re-growth of the uterus. Total abdominal hysterectomy was performed and the pathologic evaluation revealed leiomyosarcoma with a high mitotic rate. This case and the literature review emphasize the problems encountered with the early diagnosis of uterine leiomyosarcoma during GnRH agonist therapy.
Milman
D
D
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Zalel
Y
Y
Biran
H
H
Open
M
M
Caspi
B
B
Hagay
Z
Z
Dgani
R
R
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008938:Mitosis; D017329:Triptorelin Pamoate / Q000627:therapeutic use*; D014592:Uterine Hemorrhage; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology
D018931:Antineoplastic Agents, Hormonal; D017329:Triptorelin Pamoate