Role of plasma and extracellular matrix proteins in the physiopathology of foreign body infections.
Foreign body implants are highly susceptible to microorganism infection. The infectious agents may be of low pathogenicity (such as S. epidermidis) or involve more virulent strains (such as S. aureus). The common denominator for the three main elements that play a role in the physiopathology of such infections (bacteria, neutrophils, and different biomaterials) are host proteins deposited over the surface of the devices immediately after their implantation. These proteins modulate that host cells response but can also promote Staphylococcus adhesion to the biomaterial. Neutrophils and other cells such as fibroblasts adhere to several extracellular matrix proteins such as fibronectin, fibrinogen, collagen, vitronectin, via specific cell surface receptor. The evolution of the technology and the increasing numbers of long-term artificial implants require a better understanding of fundamental mechanisms of foreign body infections to reduce their incidence and optimize their treatment.
François
P
P
Division of Infectious Diseases, University Hospital, University of Geneva, Switzerland.
Vaudaux
P
P
Lew
P D
PD
D001422:Bacterial Adhesion; D001798:Blood Proteins / Q000502:physiology*; D002405:Catheterization, Central Venous; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D005549:Foreign-Body Reaction / Q000382:microbiology / Q000503:physiopathology*; D006801:Humans; D009504:Neutrophils / Q000502:physiology; D013203:Staphylococcal Infections / Q000209:etiology / Q000503:physiopathology*
D001798:Blood Proteins; D016326:Extracellular Matrix Proteins