[Inflammatory smears in cervicovaginal cytology. A finding meaning infection?].
BACKGROUND
Inflammatory changes are relatively frequent findings in cervical smears and are generally believed to be a consequence of genital infection. However, clinical signs of infection are frequently absent and no consensus exists on the management of these patients. The objective of this study was to assess whether or not inflammatory smears are exclusively a consequence of genital infection. For this purpose, the prevalence of genital infection in a group of women with inflammatory cells in the cervical smear and a control group with normal smears was compared.


METHODS
Sixty-two regularly menstruating women aged 17 to 48 years, attending the outpatient Gynaecology sector of S. João Hospital, were prospectively evaluated. Cervical smears were analysed by the same cytologist who chose 10 inflammatory cells per high power field (400x) as the cut-off value for normality. Infection by Candida spp., Trichomonas vaginalis, Neisseria gonorrhoeae, Mycoplasma hominis, Ureaplasma urealyticum, Chlamydia trachomatis and bacterial vaginosis was investigated. Human Papillomavirus infection was evaluated by colposcopy and biopsy of abnormal colposcopic findings.


RESULTS
Thirty-four women and inflammatory cells on their cervical smear and 15 of these (44%) had a genital infection. Of the 28 women with normal smears, 12 (43%) had a genital infection. No statistically significant difference in the prevalence of infection was found between the two groups.


CONCLUSIONS
Our results suggest that the presence of inflammatory cells in cervical smears is not necessarily due to infection and other causes may be responsible for their appearance.
Ayres de Campos
D
D
Departamento de Ginecologia e Obstetrícia, Hospital de São João, Porto.
Nogueira
A
A
Magalhães
F
F
Bayer
P
P
Monteiro
J
J
Lameirão
A
A
Martinez de Oliveira
J
J
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000175:diagnosis; D005260:Female; D006801:Humans; D007239:Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000175:diagnosis; D011446:Prospective Studies; D014412:Tumor Virus Infections / Q000175:diagnosis; D002575:Uterine Cervicitis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D014626:Vaginal Smears
Células inflamatórias na citologia cervicovaginal. Um achado tradutor de infecção?