Brenner tumor of the vagina.
Two cases of Brenner tumor of the vagina were encountered in postmenopausal asymptomatic women who presented with polypoid lesions measuring 0.5 and 1.2 cm, respectively, in the upper and mid-vagina. DNA flow cytometry in one tumor showed a diploid histogram, and Ki-67 (MIB-1) proliferation marker was very low in both tumors. To the best of our knowledge, only two vaginal Brenner tumors have been previously reported. Transition between the vaginal surface epithelium and the tumor in one of our cases may support a metaplastic mullerian origin for these tumors.
Ben-Izhak
O
O
Department of Pathology, Rambam Medical Center, and the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Munichor
M
M
Malkin
L
L
Kerner
H
H
D000368:Aged; D034961:Antigens, Nuclear; D001324:Autoantigens / Q000378:metabolism; D001948:Brenner Tumor / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D009687:Nuclear Proteins / Q000378:metabolism; D014625:Vaginal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
D034961:Antigens, Nuclear; D001324:Autoantigens; D019394:Ki-67 Antigen; D009687:Nuclear Proteins