[Comparison of the tocolytic and hemodynamic effects of calcium channel blockers in pregnant rats].
It was demonstrated in experiments on pregnant rats that toxolytic doses of the calcium channel blockers nifedipine, cardiazem (diltiazem) and verapamyl reduce blood pressure, heart rate, and doppler ultrasound velocity in the uterine artery. Toxolytic doses of sensit (fendilin) do not change hemodynamics in pregnant rats.
Maksimenko
E I
EI
Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg, Russia.
Zaĭtsev
A A
AA
Aĭlamazian
E K
EK
Ignatov
Iu D
IuD
Mikhaĭlov
A A
AA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005275:Fendiline / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D015149:Tocolytic Agents / Q000494:pharmacology*; D014599:Uterus / Q000098:blood supply / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D015149:Tocolytic Agents; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine; D005275:Fendiline
Sravnenie tokoliticheskogo i gemodinamicheskikh éffektov blokatorov kal'tsievykh kanalov u beremennykh krys.