[Cold agglutinins with new specificity against type 2 chains].
Two examples of IgM lambda cold agglutinins (CA) with a new specificity are characterized. 1. CAs ZI and BR react with newborn as well as with adult red cells. 2. Both CAs react with I- and i-active animal red cells. 3. The CAs are inhibited by linear and branched type 2 chains. 4. Endo-beta-galactosidase, splitting type 2 chains from human red cells, abolishes reactivity of both CAs. Both CAs recognize linear as well as branched type 2 chains.
Hack
H
H
Institut für Immunologie, Blutbank, Universität Heidelberg, Deutschland.
Kreft
H
H
Roelcke
D
D
D000328:Adult; D000373:Agglutinins / Q000276:immunology*; D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood*; D003450:Cryoglobulins; D004912:Erythrocytes / Q000276:immunology*; D006026:Glycoside Hydrolases; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D008258:Waldenstrom Macroglobulinemia / Q000097:blood* / Q000276:immunology; D001616:beta-Galactosidase
D000373:Agglutinins; D001323:Autoantibodies; D003450:Cryoglobulins; D007075:Immunoglobulin M; C029443:cold agglutinins; D006026:Glycoside Hydrolases; C026093:keratan-sulfate endo-1,4-beta-galactosidase; D001616:beta-Galactosidase
Kälteagglutinine einer neuen Spezifität gegen Typ-2-Ketten.