title: Double high-dose chemotherapy with autologous peripheral stem cell rescue in relapsed Wilms' tumor.
abstract: We performed double high-dose chemotherapy (HDCT) and autologous stem cell rescue (ASCR) on an 8-year-old girl after relapse of Wilms' tumor with unfavorable histology. Relapse occurred while the patient was still on first-line therapy and showed multiple adverse prognostic features. Since depleted hematopoietic reserves restricted further conventional therapy, a double HDCT approach was chosen to achieve maximal dose intensity. Four years after relapse the girl is in second remission and well. Double HDCT with ASCR may represent a feasible approach to rescue extensively pretreated patients with recurrent Wilms' tumor of unfavorable histology.
authors.affiliation: Department of Pediatrics, University Hospital Innsbruck, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Maurer
authors.forename: A
authors.initials: A
authors.lastname: Heitger
authors.forename: H
authors.initials: H
authors.lastname: Schwaighofer
authors.forename: F M
authors.initials: FM
authors.lastname: Fink
authors.forename: D
authors.initials: D
authors.lastname: Niederweiser
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000601:surgery / Q000628:therapy; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D016879:Salvage Therapy; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents; D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D007069:Ifosfamide