title: Kinetic analysis and comparison of uptake, distribution, and excretion of 48V-labeled compounds in rats.
abstract: Vanadium has been found to be orally active in lowering plasma glucose levels; thus it provides a potential treatment for diabetes mellitus. Bis(maltolato)oxovanadium(IV) (BMOV) is a well-characterized organovanadium compound that has been shown in preliminary studies to have a potentially useful absorption profile. Tissue distributions of BMOV compared with those of vanadyl sulfate (VS) were studied in Wistar rats by using 48V as a tracer. In this study, the compounds were administered in carrier-added forms by either oral gavage or intraperitoneal injection. Data analyzed by a compartmental model, by using simulation, analysis, and modeling (i.e., SAAM II) software, showed a pattern of increased tissue uptake with use of 48V-BMOV compared with 48VS. The highest 48V concentrations at 24 h after gavage were in bone, followed by kidney and liver. Most ingested 48V was eliminated unabsorbed by fecal excretion. On average, 48V concentrations in bone, kidney, and liver 24 h after oral administration of 48V-BMOV were two to three times higher than those of 48VS, which is consistent with the increased glucose-lowering potency of BMOV in acute glucose lowering compared with VS.
authors.affiliation: Chemsitry Department, University of British Columbia, Vancouver, Canada.
authors.forename: I A
authors.initials: IA
authors.lastname: Setyawati
authors.forename: K H
authors.initials: KH
authors.lastname: Thompson
authors.forename: V G
authors.initials: VG
authors.lastname: Yuen
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: M
authors.initials: M
authors.lastname: Battell
authors.forename: D M
authors.initials: DM
authors.lastname: Lyster
authors.forename: C
authors.initials: C
authors.lastname: Vo
authors.forename: T J
authors.initials: TJ
authors.lastname: Ruth
authors.forename: S
authors.initials: S
authors.lastname: Zeisler
authors.forename: J H
authors.initials: JH
authors.lastname: McNeill
authors.forename: C
authors.initials: C
authors.lastname: Orvig
mesh_terms: D000818:Animals; D003198:Computer Simulation; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics*; D008297:Male; D008954:Models, Biological; D011753:Pyrones / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014638:Vanadates / Q000493:pharmacokinetics*; D017968:Vanadium Compounds / Q000493:pharmacokinetics
chemical_list: D007004:Hypoglycemic Agents; D011753:Pyrones; D017968:Vanadium Compounds; C074212:bis(maltolato)oxovanadium(IV); D014638:Vanadates; C034028:vanadyl sulfate