Does a moderate hypoxia induce manganese-superoxide dismutase or heat shock proteins to act as possible protective factors?
Male Wistar rats were kept in a hypoxia chamber (9% O2) for eight hours. Control animals breathed room air in the same chamber for a similar period of time. One week later the brains of all rats were prepared for the immunohistochemical demonstration of Mn-superoxide dismutase (Mn-SOD). In comparison with the sham-exposed controls, the hypoxia-treated animals showed an increase in the number of Mn-SOD-immunoreactive neurons in several hippocampal structures. The 72 kD heat shock protein was not found to be induced one week after a moderate hypoxia.
Pohle
W
W
Department of Pharmacology and Toxicology, Faculty of Medicine of the Otto-von-Guericke-University, Magdeburg, Germany.
Rauca
C
C
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004790:Enzyme Induction; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D000860:Hypoxia / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000096:biosynthesis*
D006360:Heat-Shock Proteins; D013482:Superoxide Dismutase