hu-PBL-SCID mice: an in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease.
The Epstein-Barr virus (EBV) exists in most humans as a lifelong latent infection established in host B cells after a primary viral encounter. In immunosuppressed individuals, such as post-transplant patients, the presence of EBV-infected B cells may lead to lymphoproliferative disease. Injection of human peripheral blood lymphocytes from EBV-positive donors into mice with severe combined immunodeficiency induces human lymphoproliferative disease in the recipient closely resembling that of human post-transplant patients. This xenochimeric human-mouse model is increasingly being used to elucidate the mechanisms of EBV-specific lymphomagenesis and to assess novel therapeutic approaches.
Fuzzati-Armentero
M T
MT
Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Duchosal
M A
MA
D000818:Animals; D001402:B-Lymphocytes / Q000821:virology; D002051:Burkitt Lymphoma / Q000473:pathology* / Q000821:virology*; D004195:Disease Models, Animal; D004854:Herpesvirus 4, Human; D006801:Humans; D051379:Mice; D016513:Mice, SCID / Q000821:virology; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous