[Effect of pyrimidine derivatives on the regulation of active transport of calcium in the immunocompetent cells].
Experiments with guinea pig immunocompetent cells and nonadherent and adherent mononuclear fractions of the peripheral blood of healthy donors, and patients with rheumatoid arthritis and purulent surgical infection disclosed different levels of Ca(2+)-ATPase activity. Thymectomy in adult guinea pigs led to diminution of activity of the enzyme in all lymphoid organs. The effect of ximedon (30 mg/kg) on Ca(2+)-ATPase activity depended on the thymus and duration of treatment with the drug, and was of a two-phase character.
Slabnov
Iu D
IuD
Research Department, Republican Medical Diagnostic Center 1a, Kazan, Russia.
Cherepnev
G V
GV
Tsibul'kin
A P
AP
Karimova
F G
FG
Garaev
R S
RS
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002448:Cell Adhesion; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D011743:Pyrimidines / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D013492:Suppuration / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D013934:Thymectomy; D013950:Thymus Gland / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology / Q000378:metabolism
D011743:Pyrimidines; C069705:xymedon; D000252:Calcium-Transporting ATPases; D002118:Calcium
Vliianie pirimidinovykh proizvodnykh na sistemu reguliatsii aktivnogo transporta kal'tsiia v immunokompetentnykh kletkakh.