Chemical mixtures in the workplace. Research and practice.
1. Exposures to mixtures of chemicals in occupational settings and in the environment are of increasing concern. No single approach is appropriate for determining the risk associated with exposure to chemical mixtures. 2. The effects of coexposure of chemicals can occur in different stages of metabolism, including uptake, elimination, biotransformation, and binding. 3. Solvents represent the most widespread use of multicomponent mixtures in industry today. Solvents have the ability to inhibit the metabolism of other chemicals. 4. Lifestyle factors such as exercise, alcohol use, smoking, and the use of medications can affect the uptake and metabolism of chemicals. The effects of these factors are of particular significance in interpreting the results of biological monitoring of exposed workers.
McCauley
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Center for Research on Occupational and Environmental Toxicology, Oregon Health Sciences University, Portland, USA.
D000395:Air Pollutants, Occupational; D004347:Drug Interactions; D004784:Environmental Monitoring; D015386:Hazardous Substances; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016273:Occupational Exposure; D009785:Occupational Health Nursing; D017132:Workplace
D000395:Air Pollutants, Occupational; D015386:Hazardous Substances