The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily.
Interferon-gamma inducible protein 10 kD (IP-10) is a highly inducible, primary response gene that belongs to the C-X-C chemokine superfamily. Despite the original cloning of IP-10 in 1985, its biological functions are still unclear although accumulating reports indicate that it is a pleiotropic molecule capable of eliciting potent biological effects, including stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. More interest is now likely to be focused on IP-10 due to the recent cloning of an IP-10 receptor. This paper aims to highlight our current knowledge of IP-10 and its homologues as well as defining its likely involvement in regulating fibroproliferation following inflammatory lung injury.
Neville
L F
LF
XTL Biopharmaceuticals, Rehovot, Israel.
Mathiak
G
G
Bagasra
O
O
D000595:Amino Acid Sequence; D000818:Animals; D054357:Chemokine CXCL10; D018925:Chemokines / Q000235:genetics* / Q000276:immunology*; D019743:Chemokines, CXC; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D054357:Chemokine CXCL10; D018925:Chemokines; D019743:Chemokines, CXC; D007371:Interferon-gamma