[Specific features of pulmonary tuberculosis course in patients with insulin-dependent diabetes mellitus in relation to a varying HLA phenotype].
The examination and treatment of 67 new cases of infiltrative pulmonary tuberculous developed in the presence of insulin-dependent diabetes revealed two different types of the course of a tuberculous process. Due to therapy there was nearly complete resolution of inflammatory changes in 36 (54%) patients (Group 1). Large caseous foci of the tuberculoma type were formed in 31 (46%) patients (Group 2), including in 19 on admission and in 12 during chemotherapy Group 1 more frequently showed antigens of HLA A1 (p < 0.02) and DR2 (p < 0.01). Antigens of HLA B15 and DR6 were encountered only in this group. Those of HLA A2 (p < 0.01), DR3 (p < 0.01) were more commonly detected in Group 2. The HLA phenotype may be assumed to be an important factor that influences the course of pulmonary tuberculosis in patients with insulin-dependent mellitus and it may be of prognostic value.
Karachunskií
M A
MA
Central NII of Tuberculosis RAMN, Moscow.
Komliakova
E G
EG
Pospelov
L E
LE
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D015415:Biomarkers; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology; D004359:Drug Therapy, Combination; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D011379:Prognosis; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy / Q000276:immunology*
D000995:Antitubercular Agents; D015415:Biomarkers; D006680:HLA Antigens
Osobennosti techeniia tuberkuleza legkikh u bol'nykh insulinozavisimym sakharnym diabetom v zavisimosti ot razlichnogo HLA-fenotipa.