Brain mapping with single photon emission CT.
OBJECTIVE
To investigate the feasibility of performing brain mapping studies by using cortical activation paradigms and single photon emission computed tomography (SPECT) and to evaluate methods of analysis.


METHODS
Twenty healthy volunteers underwent technetium-99m bicisate SPECT under baseline conditions and during either full-field or right hemifield visual stimulation with a black and white reversing checkerboard pattern. Changes in regional cerebral perfusion were measured by using regions of interest (ROIs) and statistical parametric mapping.


RESULTS
ROI analysis identified statistically significant increases in perfusion in the occipital cortex with full-field visual stimulation (mean +/- standard error of the mean percentage change from baseline: left, 8.0 +/- 1.5; right, 6.6 +/- 2.4). With right hemifield visual stimulation, perfusion was significantly increased only in the left occipital cortex (left, 5.2 +/- 1.5; right, -0.2 +/- 1.9). Statistical parametric mapping showed areas of activation (more than 100 voxel clusters showed significant change from baseline at a threshold value of P < or = .005 or z > or = 2.58) in the left primary visual cortex (right hemifield visual stimulation) and in both right and left primary visual areas (full-field visual stimulation).


CONCLUSIONS
Brain mapping studies were preformed with Tc-99m bicisate SPECT, and activation-induced changes were visualized and measured. These methods can be applied to develop improved methods of diagnosis and assessment of treatment outcome in patients with neuropsychiatric disorders.
Matthew
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Department of Radiologic Sciences, Beth Israel Deaconess Medical Center-West Campus, Harvard Medical School, Boston, MA 02215, USA.
Hill
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TC
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D003545:Cysteine / Q000031:analogs & derivatives*; D005074:Evoked Potentials, Visual; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D015609:Organotechnetium Compounds; D010775:Photic Stimulation; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014793:Visual Cortex / Q000000981:diagnostic imaging / Q000502:physiology*
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine