Association between hyperhomocysteinemia and ischemic heart disease in Sri Lankans.
OBJECTIVE
The objective of this study was to examine the relation between hyperhomocysteinaemia and ischemic heart disease in a cohort of Sri Lankan patients with ischemic heart disease.


METHODS
Serum homocysteine, cysteine and cysteinylglyceine were measured in 54 patients with a definite diagnosis of ischemic heart disease and compared with those of an age and sex matched control group.


RESULTS
Patients with coronary ischaemia had significantly higher mean concentrations of homocysteine and its metabolite cysteine (P<0.01). Of the 54 patients with ischemic heart disease 14 (35%) had fasting homocysteine concentrations above the 90th percentile of the controls (odds ratio 3.2, 95% CL 1.0-11.3).


CONCLUSIONS
Hyperhomocysteinaemia is associated with a three fold increase in coronary risk.
Mendis
S
S
Department of Medicine, Faculty of Medicine, Peradeniya, Sri Lanka.
Athauda
S B
SB
Takashi
K
K
D000328:Adult; D000368:Aged; D015984:Causality; D015331:Cohort Studies; D003545:Cysteine / Q000097:blood; D004151:Dipeptides / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology*; D016017:Odds Ratio; D012016:Reference Values; D012307:Risk Factors; D013188:Sri Lanka / Q000453:epidemiology
D004151:Dipeptides; D006710:Homocysteine; C028505:cysteinylglycine; D003545:Cysteine