[Effect of sex hormones on lipid peroxidation in the rat aorta].
The effect of sex hormones on lipid peroxidation (LPO) in the wall of the aorta of male rats was studied in vivo and in vitro. Female sex hormones (17 beta-estradiol and progesterone) inhibited LPO in the aorta: 17 beta-estradiol caused a maximum antioxidant effect at the beginning of its action, progester one during prolonged action. Testosterone had a marked prooxidant effect, activating lipid LPO in the aorta both in vivo and in vitro whatever its concentration and duration of incubation.
Karachentsev
A N
AN
Russian State Medical University, Moscow, Russia.
Mel'chenko
I A
IA
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000378:metabolism; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D011374:Progesterone; D004958:Estradiol
Perekisnoe okislenie lipidov v aorte krysy pri deĭstvii polovykh gormonov.