Antigen receptor-initiated signals for B cell development and selection.
The B cell antigen receptor or signaling components of this receptor play varying roles in determining the fate of the B cell at different stages of B cell development. Signals generated through this receptor complex or its various components determine the survival, progression, expansion, and activation of the B cell. Factors that determine the fate of the B cell following antigen receptor engagement include the developmental stage, coreceptor expression, degree and stability of ligand-receptor engagement, and the availability of T cell-derived secondary signals. The author's laboratory is interested in defining the molecular processes linking B cell antigen receptor signaling to these specific cellular responses in the context of antigen-independent and dependent B cell development. Here our current progress and thinking with regard to the determination between negative selection and activation as it pertains to the transition from the immature- to the mature-stage B cell will be discussed.
Monroe
J G
JG
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA. monroej@mail.med.upenn.edu
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D008024:Ligands; D008211:Lymphocyte Cooperation; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D008024:Ligands; D011947:Receptors, Antigen, B-Cell