title: Changes in right ventricular filling dynamics during left anterior descending, left circumflex and right coronary artery balloon occlusion.
abstract: OBJECTIVE
  Transient coronary artery occlusion during percutaneous transluminal coronary angioplasty may cause left ventricular diastolic dysfunction. The aim of this study was to evaluate the effect of left anterior descending, left circumflex and right coronary artery balloon occlusion on right ventricular diastolic function.
  
  
  METHODS
  Thirty-five patients with single-vessel coronary artery disease and no previous myocardial infarction were selected. Left and right ventricular filling pressures were monitored by Doppler echocardiography and haemodynamic monitoring. This was performed during and immediately after 60 s of coronary balloon occlusion of the left anterior descending artery in 21 cases (Group 1), the left circumflex artery in eight cases (Group 2) and the right coronary artery in six cases (Group 3). Doppler analysis of left and right ventricular filling included peak velocity of early (PFVE) and late ventricular filling (PFVA) and PFVE to PFVA ratio (PFVE/PFVA).
  
  
  RESULTS
  In all three groups, balloon inflation induced a significant increase in left and right filling pressures (P < 0.05). No qualitative difference in haemodynamic changes was found between groups during inflation. Significant impairment in the Doppler pattern of left and right ventricular filling occurred after 20 s of coronary occlusion: PFVE values in mitral and tricuspid valves decreased by 14% and 25% in Group 1, 13% and 25% in Group 2, and 10% and 21% in Group 3, respectively, as PFVA remained unchanged in all groups, the PFVE/PFVA ratio of mitral and tricuspid valve flows significantly decreased (Group 1: -12% and -20%, Group 2: -10% and -21%, Group 3: -14% and -21%, respectively). All parameters returned to baseline within 30 s after each balloon deflation.
  
  
  CONCLUSIONS
  Our data suggest that brief episodes of acute myocardial ischaemia, such as those induced by 60 s of coronary artery occlusion during percutaneous transluminal coronary angioplasty, elicit simultaneous diastolic dysfunction of both ventricles, independent of the coronary artery involved.
authors.affiliation: Istituto di Cardiologia dell'Universitá degli Studi di Milano, Fondazione I. Monzino IRCCS, Milan Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fabbiocchi
authors.forename: C
authors.initials: C
authors.lastname: Galli
authors.forename: P
authors.initials: P
authors.lastname: Sganzerla
authors.forename: P
authors.initials: P
authors.lastname: Montorsi
authors.forename: A
authors.initials: A
authors.lastname: Loaldi
authors.forename: N
authors.initials: N
authors.lastname: de Cesare
authors.forename: A L
authors.initials: AL
authors.lastname: Bartorelli
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology; D012039:Regional Blood Flow; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000503:physiopathology*