Triplex-directed modification of genes and gene activity.
Oligonucleotides offer enormous potential for manipulating gene function in cells and, as such, constitute a promising new class of pharmaceutical agents. Oligonucleotides that form triple helices (triplexes) at specific DNA sequences in defined genes can be used to reduce transcription selectively, to introduce site-specific mutations or to stimulate gene-specific targeted recombination.
Vasquez
K M
KM
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Wilson
J H
JH
D000818:Animals; D015870:Gene Expression; D015316:Genetic Therapy; D006801:Humans; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*
D009841:Oligonucleotides