title: [An unusual course of viral hepatitis A in children].
abstract: To determine the present-day specific clinical features of viral hepatitis A (HA) in children, observation on 447 children aged 1 year and 10 months to 14 years with verified HA monoinfection was carried out. At the season of 1993 essential differences were observed in the clinical picture of HA: the disease took a more severe course with the prevalence of medium-severe (59.3%) and severe (3.6%) forms of this infection, a tendency to a prolonged convalescence period and fermentative aggravations, an increase in the occurrence of cholestatic forms. One of the causes of this phenomenon may be attributed to changes in the properties of the infective agent.
authors.affiliation: Central Research Institute of Epidemiology, Moscow, Russia.
authors.forename: A R
authors.initials: AR
authors.lastname: Reĭzis
authors.forename: A K
authors.initials: AK
authors.lastname: Drondina
authors.forename: T S
authors.initials: TS
authors.lastname: Nikitina
authors.forename: N A
authors.initials: NA
authors.lastname: Zamiatina
authors.forename: M I
authors.initials: MI
authors.lastname: Mikhaĭlov
authors.forename: A A
authors.initials: AA
authors.lastname: Asratian
authors.forename: A P
authors.initials: AP
authors.lastname: Stulov
authors.forename: N P
authors.initials: NP
authors.lastname: Anan'eva
authors.forename: G V
authors.initials: GV
authors.lastname: Mel'nikova
authors.forename: M A
authors.initials: MA
authors.lastname: Svanidze
authors.forename: A I
authors.initials: AI
authors.lastname: Kosorotikova
authors.forename: A P
authors.initials: AP
authors.lastname: Evgrafova
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003289:Convalescence; D005243:Feces / Q000737:chemistry; D006506:Hepatitis A / Q000175:diagnosis*; D017957:Hepatitis A Virus, Human / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood; D018963:Hepatitis Antigens / Q000032:analysis; D006801:Humans; D007223:Infant; D013997:Time Factors
chemical_list: D015415:Biomarkers; D006508:Hepatitis Antibodies; D018963:Hepatitis Antigens
vernacular_title: Neobychnoe techenie virusnogo gepatita A u deteĭ.