[Optimum quinine therapy in falciparum malaria attacks contracted in Africa].
A review about the use of quinine for uncomplicated falciparum malaria contracted in Africa is proposed. The dose of 8 mg/kg of quinine base 3 times a day seems to be admitted by all. On the other way, the duration of treatment fluctuates from 2 to 10 days without evidence of difference in efficacy between 3, 5 and 7 days. The pharmacodynamic and pharmacokinetic properties of quinine are reviewed and suggest that 3, 5 and 7 days are efficient at least on, respectively, 1, 2 and 3 parasite cycles and suggest that a five day treatment may be curative for all kind of patients infested with a quinine-sensitive strain of P. falciparum in Africa.
Clain
J
J
Service de parasitologie & centre national de référence de la chimiosensibilité du paludisme (CNRCP), Hôpital Bichat-Claude-Bernard, Paris.
Peytavin
G
G
Gachot
B
B
Vachon
F
F
Le Bras
J
J
D000349:Africa / Q000208:ethnology; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005602:France / Q000453:epidemiology; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000208:ethnology*; D011803:Quinine / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D000962:Antimalarials; D011803:Quinine
Du bon usage thérapeutique de la quinine dans l'accès palustre à P. falciparum contracté en Afrique.