Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype.
Two new pimarane diterpenoids, lonchophylloids A (1) and B (2), were isolated from the stems of Ephemerantha lonchophylla. The structures of 1 and 2 were established predominantly through the application of extensive 1H-and 13C-NMR, 1D- and 2D-homonuclear and heteronuclear correlation NMR experiments, and X-ray diffraction methods. Consistent with structure--activity predictions, both compounds were capable of sensitizing cells that expressed the multidrug resistance phenotype to the toxicity of the anticancer drug doxorubicin.
Na
G X
GX
Institute of Traditional Chinese Medicine and Pharmacology, Nanjing University of Traditional Chinese Medicine, People's Republic of China. gma@gamma.is.tuc.edu
Wang
T S
TS
Yin
L
L
Pan
Y
Y
Guo
Y L
YL
LeBlanc
G A
GA
Reinecke
M G
MG
Watson
W H
WH
Krawiec
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D019450:Genes, MDR / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010616:Phenanthrenes / Q000302:isolation & purification* / Q000494:pharmacology; D010641:Phenotype; D018547:Plant Stems / Q000737:chemistry; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes; C110799:lonchophylloid A; C110800:lonchophylloid B; D004317:Doxorubicin