title: Early detection of cardiac damage with heart fatty acid-binding protein after cardiac operations.
abstract: BACKGROUND
  It is still difficult to evaluate myocardial damage in the acute phase of reperfusion in cardiac operations. We investigated the clinical significance of human heart fatty acid-binding protein (HH-FABP) for detecting myocardial damage after cardiac operations earlier than creatine kinase MB isoform or troponin-T.
  
  
  METHODS
  Blood samples from 20 patients who underwent coronary artery bypass grafting were collected serially after reperfusion to measure serum levels of creatine kinase-MB, troponin-T, and HH-FABP.
  
  
  RESULTS
  Serum HH-FABP levels peaked earliest after reperfusion. In addition, the maximum serum HH-FABP level was predictable immediately after reperfusion. The maximum serum HH-FABP level correlated with the maximum serum creatine kinase-MB or troponin-T level, as well as with the aortic cross-clamp time or the maximum dose of catecholamines administered after reperfusion.
  
  
  CONCLUSIONS
  Measurements of HH-FABP allow for earlier evaluation of myocardial damage in the acute phase of reperfusion. Human heart fatty acid-binding protein may be a useful indicator of myocardial damage after cardiac operations.
authors.affiliation: First Department of Surgery, Osaka University, Suita, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Sawa
authors.forename: K
authors.initials: K
authors.lastname: Kadoba
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
authors.forename: K
authors.initials: K
authors.lastname: Kagisaki
authors.forename: T
authors.initials: T
authors.lastname: Ohata
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002352:Carrier Proteins / Q000097:blood*; D002395:Catecholamines / Q000008:administration & dosage; D001026:Coronary Artery Bypass / Q000009:adverse effects; D003402:Creatine Kinase / Q000097:blood; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D018996:Myelin P2 Protein / Q000097:blood*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis*; D009363:Neoplasm Proteins; D014336:Troponin / Q000097:blood; D025521:Tumor Suppressor Proteins
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; D002395:Catecholamines; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D007527:Isoenzymes; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D014336:Troponin; D025521:Tumor Suppressor Proteins; D003402:Creatine Kinase