[Immune reaction to human cytomegalovirus].
Cytomegalovirus(CMV) infection is an important infection in immunocompromised host. Cell mediated immunity is important in recovery from CMV infection. CMV-specific cytotoxic T lymphocytes(CTL), natural killer (NK) cells can lyse CMV-infected cells. Expression of HLA class I antigen is decreased in CMV-infected cells. CMV-infected cells that has lost cell-surface expression of MHC class I to avoid CTL attack may be susceptible to NK cell-mediated cytotoxicity. Lymphocytes activation in response to CMV antigen is observed in CD45RO memory T cells and adhesion molecules are responsible for adherence of lymphocytes to CMV-infected cells. Cytokines has an important role in recovery from CMV infection.
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Department of Pediatrics, Mie University School of Medicine.
D015815:Cell Adhesion Molecules / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular; D016867:Immunocompromised Host / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D015815:Cell Adhesion Molecules; D016207:Cytokines; D015395:Histocompatibility Antigens Class I