Derivatives of asparagic acid with hypotensive action.
To obtain new compounds with biological activity, 1-[N-(p-nitrobenzoyl)-alpha-D,L- asparagyl]-benzimidazole derivatives were synthesized by decyclization of 2-(p-nitrophenyl)-4-[2'- (diethylamino) ethyl-carboxymethyl]-delta 2-oxazolinone-5 with benzimidazole, 2-methylbenzimidazole and 5,6-dimethyl-benzimidazole. The synthesized products show a hypotensive action comparable to that Hipopresol.
Sunel
V
V
Department of Organic Chemistry, University Al. I. Cuza, Iassy.
Ciugureanu
C
C
Ungureanu
M
M
D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry* / Q000494:pharmacology; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D013329:Structure-Activity Relationship
D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001224:Aspartic Acid