Effects of C-type natriuretic peptide on renal vasoconstriction in dogs.
Intrarenal arterial infusion of C-type natriuretic peptide (CNP, 50 ng/kg per min) increased urine flow rate without affecting glomerular filtration rate. Intrarenal arterial bolus injection of angiotensin II (25, 50 and 100 ng) or of norepinephrine (0.25, 0.5 and 1.0 microg) reduced renal blood flow. The blood flow response induced by angiotensin II was slightly attenuated but the response induced by norepinephrine was unaffected during CNP infusion. These results suggest that exogenous CNP, even at the pharmacological dose that can induce diuresis, has little effect on the canine renal vasculature.
Yoshida
K
K
Department of Pharmacology, Pharmaceutical Institute, Tohoku University, Sendai, Japan.
Yamagata
T
T
Tomura
Y
Y
Suzuki-Kusaba
M
M
Yoshida
M
M
Hisa
H
H
Satoh
S
S
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D008297:Male; D020098:Natriuretic Peptide, C-Type; D009638:Norepinephrine / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects*; D012964:Sodium / Q000652:urine; D014563:Urodynamics / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D011506:Proteins; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D020098:Natriuretic Peptide, C-Type; D009320:Atrial Natriuretic Factor; D012964:Sodium; D009638:Norepinephrine