title: B cell maturation and selection at the marrow-periphery interface.
abstract: More than 95% of newly formed B cells die in the short interval spanning sIgM acquisition in the bone marrow and entry into the long-lived pool, suggesting that selective events dictating B cell longevity occur at this stage. These likely include both ligand-induced deletion as well as discrete events that mediate recruitment to the long-lived recirculating pool. We are probing these events through the examination of normal B cell differentiation during this critical period: the characterization of a natural mutation that blocks late maturation, an irradiation/autoreconstitution model of marrow-derived B cell differentiation, and the identification of life span regulatory genes whose expression changes within this window.
authors.affiliation: Dept. of Pathol., Univ. of Penn., Philadelphia 19104, USA. cancro@mail.med.upenn.edu
authors.forename: M P
authors.initials: MP
authors.lastname: Cancro
authors.forename: D M
authors.initials: DM
authors.lastname: Allman
authors.forename: C E
authors.initials: CE
authors.lastname: Hayes
authors.forename: V M
authors.initials: VM
authors.lastname: Lentz
authors.forename: R G
authors.initials: RG
authors.lastname: Fields
authors.forename: A P
authors.initials: AP
authors.lastname: Sah
authors.forename: M
authors.initials: M
authors.lastname: Tomayko
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D009154:Mutation
chemical_list: D007075:Immunoglobulin M