New cembranolides from the gorgonian Eunicea succinea.
A new chemical study of the Caribbean gorgonian Eunicea succinea collected in Puerto Rico afforded seven new cembranolides (1-5, 7, and 8). Excepting 1, the new compounds described here possess an unusual unsaturation at either position C-1, C-6, or C-8, and all but 8 possess the C-12R, C-13S stereochemistry usually ascribed to cembranolides from E. succinea. Their chemical structures were carefully established by a combination of chemical and spectroscopic methods in addition to detailed NMR spectral comparisons with known cembranolide models.
Rodríguez
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AD
Department of Chemistry, University of Puerto Rico, Rio Piedras. abrodrig@upracd.upr.clu.edu
Acosta
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AL
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011647:Puerto Rico; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes