Some serum activity markers of airways inflammation in difficult-to-control asthma patients.
The main aim of the present study was a search for a characteristic serum marker of inflammatory activity in the airways of asthmatics with difficult-to-control disease. Therefore, serum levels of interleukin-4 (IL-4), serum low-affinity Fc Epsilon Receptor II (sFcER II), Interferon-gamma (INF-gamma) Immunoglobulin-E (IgE), Interleukin-2 (IL-2), serum Interleukin Receptor 2 (sIL-2R) and Intercellular Adhesion Molecule-1 (sICAM-1) were measured in 2 groups of asthmatics: 1-26 patients with difficult-to-control asthma (DTCA), 2-22 asthmatics, minimally symptomatic (MSA).


RESULTS
No significant difference in either measured parameters between the DTCA and MSA group in peripheral blood samples was found.


CONCLUSIONS
The above mentioned serum markers of T- and B-cell activation as well as the serum ICAM-1 level are not sensitive enough to determine the type, activity and severity of the inflammatory process in the asthmatic airways.
Král
B
B
IInd Department of Medicine, Charles University, Faculty of Medicine, Hradec Králové.
Krejsek
J
J
Paráková
Z
Z
Kopecký
O
O
Vokurková
D
D
Derner
V
V
Tousková
M
M
D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines; D007073:Immunoglobulin E