Lung fibrosis induced by paclitaxel.
In a 59-year old man with IIIb non-small-cell lung cancer, a combined treatment with paclitaxel and carboplatin was used for potentiation of radiotherapy. The patient was alive and free of neoplastic disease 14 months after the end of treatment but irreversible lung fibrosis had developed.
Sotiriou
C
C
Service de Médecine Interne, Institut Jules Bordet, Université Libre de Bruxelles, Belgium.
van Houtte
P
P
Klastersky
J
J
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000532:radiotherapy; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis; D011838:Radiation-Sensitizing Agents / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D011838:Radiation-Sensitizing Agents; D016190:Carboplatin; D017239:Paclitaxel