title: [The antioxidant systems in rheumatoid polyarthritis].
abstract: The inflammatory process from rheumatoid arthritis (RA) is marked by complexity, maintenance and destruction. The inflammatory lesions are induced by oxygen free radicals, that have a great capacity of destruction. We studied 52 patients with RA (defined by ARA criteria--1987). We have observed the inflammatory rheumatic syndrome, humoral and cellular immune syndrome and the antioxidant systems, i.e.: superoxidedismutaze, glutathione and its fractions, glutathione peroxidase, the total SH groups. We have observed the decrease of the glutathione in 40% of patients and the decrease of the total SH groups in 65% of patients. The total SH groups are correlated with the severe forms of the disease. Superoxide dismutase had decrease values in 85% of cases. We have remarked that the treatment with corticosteroids and D-penicillamina improved the serum levels of the glutathione and total SH groups.
authors.affiliation: Departamentul de Reumatologie şi Recuperare, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: R
authors.initials: R
authors.lastname: Chiriac
authors.forename: E
authors.initials: E
authors.lastname: Rezuş
authors.forename: B
authors.initials: B
authors.lastname: Florică
authors.forename: C
authors.initials: C
authors.lastname: Chiriac
authors.forename: B
authors.initials: B
authors.lastname: Bucur
authors.forename: O
authors.initials: O
authors.lastname: Popârda
authors.forename: G
authors.initials: G
authors.lastname: Mancaş
authors.forename: I
authors.initials: I
authors.lastname: Palamaru
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides
vernacular_title: Sistemele antioxidante în poliartrita reumatoidă.