title: Sequence and function of the two P domain potassium channels: implications of an emerging superfamily.
abstract: A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two P domain channels have been isolated thus far; among these are the first cloned examples of outward rectifier and open rectifier (or leak) K+ channels. The two P domain K+ channels offer a new perspective from which to glimpse the molecular basis for function and dysfunction of K+-selective ion channels.
authors.affiliation: Department of Pediatrics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Goldstein
authors.forename: K W
authors.initials: KW
authors.lastname: Wang
authors.forename: N
authors.initials: N
authors.lastname: Ilan
authors.forename: M H
authors.initials: MH
authors.lastname: Pausch
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D015221:Potassium Channels / Q000737:chemistry* / Q000502:physiology*; D013329:Structure-Activity Relationship
chemical_list: D015221:Potassium Channels