An open study of the anti-TNF alpha agent pentoxifylline in the treatment of rheumatoid arthritis.
OBJECTIVE
Monoclonal antibodies to TNF alpha have a rapid therapeutic effect in rheumatoid arthritis. Pentoxifylline is an anti-TNF alpha agent that is easier to handle than antibodies.


METHODS
An open prospective trial was conducted in 21 patients with active rheumatoid arthritis. Pentoxifylline was given in a daily dosage of 1,200 mg for at least one month. Five patients received the drug as a continuous intravenous infusion during the first seven days.


RESULTS
After one month, a significant decrease in the pain severity score was noted, but all other clinical and laboratory efficacy parameters were unchanged. A limited response was seen in four patients. TNF alpha levels did not decrease under therapy.


CONCLUSIONS
Under the conditions of our trial, the therapeutic benefits provided by pentoxifylline were too small to warrant use of this drug in severe refractory rheumatoid arthritis.
Dubost
J J
JJ
Clinical Immunology Unit, Gabriel-Montpied Hospital, Clermont-Ferrand, France.
Soubrier
M
M
Ristori
J M
JM
Beaujon
G
G
Oualid
T
T
Bussière
J L
JL
Sauvezie
B
B
D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010431:Pentoxifylline / Q000627:therapeutic use*; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D010431:Pentoxifylline