Altered catecholamine synthesis and degradation in the epidermis of patients with atopic eczema.
Patients with atopic eczema have significantly higher norepinephrine levels in plasma than healthy controls. In addition, significantly higher levels of the essential cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (6BH4) were found in this patient group. Cell extracts from epidermal suction blister roofs revealed only half the normal activity of phenylethanolamine-N-methyl transferase (PNMT) together with a threefold induction of the norepinephrine-degrading enzyme monoamine oxidase A (MAO-A). Taken together, these results support earlier observations of a defective catecholamine/adrenoceptor signal in patients with atopic eczema.
Schallreuter
K U
KU
Clinical and Experimental Dermatology Department of Biomedical Sciences, University of Bradford, UK. K.Schallreuter@Bradford.ac.uk
Pittelkow
M R
MR
Swanson
N N
NN
Beazley
W D
WD
Körner
C
C
Ehrke
C
C
Büttner
G
G
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002395:Catecholamines / Q000096:biosynthesis*; D002478:Cells, Cultured; D002648:Child; D003876:Dermatitis, Atopic / Q000378:metabolism*; D004817:Epidermis / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology*
D002395:Catecholamines; D018343:Receptors, Adrenergic, beta-2; D009638:Norepinephrine; D004837:Epinephrine