Proaggregatory and procoagulant properties of three murine mammary gland tumor cell lines with different metastatic capabilities.
We have investigated the in vitro proaggregatory and procoagulant properties of three murine tumor cell lines having different metastatic potentials. The characterization was carried out with appropriate procoagulant inhibitors and plasma deficient in factors VII and X. The proaggregatory properties of M2, M3 and MM3 cell lines increased according to their metastatic potentials. Their procoagulant activity were dependent on factor X. The prothrombotic abilities exhibited by neoplastic cells (NC), acting synergistically, might play a role in cancer dissemination.
Pasqualini
M E
ME
Departamento de Histología, Embriología y Genética, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Ruiz Moreno
L
L
Muñoz
S E
SE
Eynard
A R
AR
D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology; D000818:Animals; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D003546:Cysteine Endopeptidases / Q000097:blood; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000097:blood / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis / Q000473:pathology*; D009363:Neoplasm Proteins; D010974:Platelet Aggregation; D010976:Platelet Count; D014407:Tumor Cells, Cultured
D009363:Neoplasm Proteins; D003546:Cysteine Endopeptidases; C030910:cancer procoagulant