A synthetic model of intra-Golgi traffic.
We present a hypothesis on the mechanisms used by cells to transport cargo through the secretory system. We propose that at least three basic processes coordinately participate in membrane traffic: cisternal maturation-progression, controlled cargo diffusion along transient membrane continuities between different compartments, and a mostly retrograde vesicle-mediated transport. A 'synthetic' model based on the combination of these mechanisms can explain both the progression of supramolecular aggregates through the secretory pathway and the fast intra-Golgi transport of conventional cargoes. Analysis of the existing literature shows that the available data are consistent with the proposed model.
Mironov
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Laboratory of Molecular Neurobiology, Mario Negri Sud Institute, Chieti, Italy.
Luini
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Mironov
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D004721:Endoplasmic Reticulum / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology*; D007425:Intracellular Membranes / Q000502:physiology*; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism
D011506:Proteins