title: [The use of sirdalud in painful muscle tonic syndromes].
abstract: The paper considers mechanisms of action and clinical efficacy of the drug sirdalud (tizanidine) in painful musculotonic syndromes. Sirdalud is an agonist of alpha 2-adrenergic receptors effective in painful musculotonic syndromes and spasticity of various genesis. The drug exhibits myorelaxative and direct central analgetic effects, is well tolerated and has minimal side effects (drowsiness). The response can be seen as early as the first treatment days. Sirdalud is applicable as alone and in combination with non-steroid anti-inflammatory drugs.
authors.forename: I V
authors.initials: IV
authors.lastname: Damulin
mesh_terms: D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D009125:Muscle Relaxants, Central / Q000008:administration & dosage* / Q000009:adverse effects; D009128:Muscle Spasticity / Q000188:drug therapy; D009129:Muscle Tonus / Q000187:drug effects*; D009135:Muscular Diseases / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy*; D013577:Syndrome
chemical_list: D009125:Muscle Relaxants, Central; C023754:tizanidine; D003000:Clonidine
vernacular_title: Primenenie sirdaluda pri bolevykh myshechno-tonicheskikh sindromakh.