title: The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22.
abstract: We isolated the human glutamate receptor delta 2 (GRID2) gene, which has 97.0% identity in amino acid sequence to the mouse glutamate receptor delta 2 (Grid2) gene. We subsequently mapped this gene to human chromosome 4q22 by radiation hybrid mapping and by hybridization to two overlapping human yeast artificial chromosomes that are located in 4q22. The Grid2 gene, which is mutated in lurcher (Lc) mice, maps to mouse chromosome 6. Thus, the mapping of the GRID2 gene to human chromosome 4q22 confirms and refines a region of synteny between mouse and human genomes.
authors.affiliation: Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA.
authors.forename: W
authors.initials: W
authors.lastname: Hu
authors.forename: J
authors.initials: J
authors.lastname: Zuo
authors.forename: P L
authors.initials: PL
authors.lastname: De Jager
authors.forename: N
authors.initials: N
authors.lastname: Heintz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002525:Cerebellar Cortex / Q000502:physiology; D002874:Chromosome Mapping / Q000379:methods; D002894:Chromosomes, Human, Pair 4; D003001:Cloning, Molecular; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells / Q000528:radiation effects; D017403:In Situ Hybridization / Q000379:methods; D051379:Mice; D008969:Molecular Sequence Data; D017470:Receptors, Glutamate / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D005819:Genetic Markers; D017470:Receptors, Glutamate; C107913:glutamate receptor delta 2