title: [The effects of long-term captopril treatment on the evolution of urinary albumin excretion in patients with non-insulin-dependent diabetes mellitus].
abstract: OBJECTIVE
  To identify diabetics not dependent on insulin (DNDI) who are carriers of clinical proteinuria and microalbuminuria susceptible to captopril treatment and to evaluate the evolution of the urinary excretion of albumin (UEA) rate after three years of follow-up.
  
  
  METHODS
  A prevalence study followed by an intervention and follow-up over 3 years.
  
  
  METHODS
  The urban Health Centre "San Agustín" in Burgos.
  
  
  METHODS
  107 DNDI included in the "Diabetes programme".
  
  
  METHODS
  Patients with increased UEA were treated with 25 mg of captopril (Capoten) every 12 hours for 3 years.
  
  
  RESULTS
  A steady drop in the UEA of patients with microalbuminuria was observed in their third year of treatment (p = 0.01). 5 patients (41.6%) became negative (p = 0.01).
  
  
  CONCLUSIONS
  Captopril treatment reduced levels of UEA in DNDI who had high UEA. Significantly, evolution to clinical proteinuria of patients with persistent microalbuminuria was avoided.
authors.affiliation: Centro de Salud San Agustín, Unidad Docente de Medicina Familiar y Comunitaria, Burgos.
authors.forename: M L
authors.initials: ML
authors.lastname: González Castro
authors.forename: J
authors.initials: J
authors.lastname: Cordero Guevara
authors.forename: A
authors.initials: A
authors.lastname: Sáez Fernández
authors.forename: J
authors.initials: J
authors.lastname: Sagredo Pérez
authors.forename: E
authors.initials: E
authors.lastname: Arrojo Arias
authors.forename: V
authors.initials: V
authors.lastname: del Saz Moreno
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology / Q000652:urine; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril; D006442:Glycated Hemoglobin
vernacular_title: Efectos del tratamiento a largo plazo con captopril sobre la evolución de la excreción urinaria de albúmina en pacientes con diabetes mellitus no insulinodependiente.