Suppression of the number of aberrant crypt foci of rat colorectum by ingestion of sugar beet fiber regardless of administration of anti-asialo GM1.
Anti-asialo GM1 serum (AGM1) reduces natural killer (NK) activity in vitro and in vivo. We investigated the effect of ingestion of sugar beet fiber (SBF) on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) and whether the effect was maintained under NK-reducing conditions by AGM1 injection. The ingestion of SBF decreased the number of ACF in the colorectum at 4 weeks after treatment with DMH. Dietary SBF had a suppressive effect on the formation of ACF regardless of the administration of AGM1. These results suggest that the suppressive effect created by the ingestion of SBF may overwhelm the effect of AGM1 treatment on ACF formation.
Ishizuka
S
S
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan. zuka@chem.agr.hokudai.ac.jp
Kasai
T
T
D000818:Animals; D019663:Chenopodiaceae; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology*; D003111:Colonic Polyps / Q000473:pathology*; D004043:Dietary Fiber / Q000494:pharmacology*; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011230:Precancerous Conditions / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000254:growth & development
D004043:Dietary Fiber; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside