title: Magna-field irradiation: work in progress in bone marrow transplantation at The Princess Margaret Hospital, Toronto.
abstract: Our work with total body irradiation (TBI) for acute leukemia in relapse dates from 1959. Following reports of the Seattle experience, we treated a small number of patients in remission--lowering the dose to 500 rad given at 50 rad/min, based in part on our experience with radiation pneumonitis complicating upper HBI. We have treated 51 patients since July 1979, with an actuarial survival of 65% overall, and 85% for patients 35 years-old or less. A specially designed cobalt-60 unit is used, which allows very large fields and high exposure rates. Dose is calculated at midplane and a homogeneity of +/- 5% obtained.
authors.affiliation: The Princess Margaret Hospital, Toronto, Ontario, Canada.
authors.forename: W D
authors.initials: WD
authors.lastname: Rider
authors.forename: H A
authors.initials: HA
authors.lastname: Messner
mesh_terms: D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D017619:Hemibody Irradiation; D006801:Humans; D007938:Leukemia / Q000000981:diagnostic imaging* / Q000628:therapy; D009864:Ontario; D017564:Radiation Pneumonitis / Q000209:etiology; D011859:Radiography; D011879:Radiotherapy Dosage; D012008:Recurrence; D016896:Treatment Outcome; D014916:Whole-Body Irradiation / Q000379:methods*