Effect of simvastatin on ischemic signs and symptoms in the Scandinavian simvastatin survival study (4S).
In patients participating in the Scandinavian Simvastatin Survival Study, cholesterol lowering with simvastatin reduced the incidence of carotid bruits and cerebrovascular events as well as new-onset or worsening of angina pectoris and intermittent claudication. These effects suggest that simvastatin may have a general antiatherosclerotic effect not limited to the coronary bed.
Pedersen
T R
TR
Aker Hospital, Oslo, Norway.
Kjekshus
J
J
Pyörälä
K
K
Olsson
A G
AG
Cook
T J
TJ
Musliner
T A
TA
Tobert
J A
JA
Haghfelt
T
T
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000150:complications / Q000517:prevention & control*; D018450:Disease Progression; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007511:Ischemia / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D019821:Simvastatin / Q000627:therapeutic use*; D016896:Treatment Outcome
D000960:Hypolipidemic Agents; D019821:Simvastatin