title: Platelet activating factor antagonist activity of ginsenosides.
abstract: Ginseng saponins and their degradation products have been screened for antagonist activity towards [3H]PAF (platelet activating factor) in washed rabbit platelet receptor binding studies. 20(S)- and delta20-ginsenosides Rg3, protopanaxadiol-type saponins, were found to be relatively potent PAF antagonists (IC50 = 4.9 x 10(-5) M and 9.2 x 10(-5) M, respectively).
authors.affiliation: Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Taejon.
authors.forename: K Y
authors.initials: KY
authors.lastname: Jung
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
authors.forename: S R
authors.initials: SR
authors.lastname: Oh
authors.forename: I S
authors.initials: IS
authors.lastname: Lee
authors.forename: J J
authors.initials: JJ
authors.lastname: Lee
authors.forename: J D
authors.initials: JD
authors.lastname: Park
authors.forename: S I
authors.initials: SI
authors.lastname: Kim
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002021:Buffers; D036145:Ginsenosides; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism; D011817:Rabbits; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D012503:Saponins / Q000494:pharmacology*
chemical_list: D002021:Buffers; D036145:Ginsenosides; D007202:Indicators and Reagents; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D012503:Saponins; C039351:platelet activating factor receptor