The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism.
The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen-identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1-negative allelic counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1-induced GvHD development.
den Haan
J M
JM
Department of Immunohematology and Bloodbank, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Meadows
L M
LM
Wang
W
W
Pool
J
J
Blokland
E
E
Bishop
T L
TL
Reinhardus
C
C
Shabanowitz
J
J
Offringa
R
R
Hunt
D F
DF
Engelhard
V H
VH
Goulmy
E
E
D000483:Alleles; D000595:Amino Acid Sequence; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002460:Cell Line; D002461:Cell Line, Transformed; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D015234:HLA-A Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D015778:Minor Histocompatibility Antigens / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D008912:Minor Histocompatibility Loci; D009842:Oligopeptides / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
C110615:HA-1 antigen; D015234:HLA-A Antigens; D015778:Minor Histocompatibility Antigens; D009842:Oligopeptides