title: [Occurrence of prostatic intraepithelial neoplasia in needle biopsy of the prostate and its clinical significance].
abstract: From March 1994 to September 1996 485 patients of median age 67 years (range 49-82) underwent transrectal prostate needle biopsy at the Urological Clinic JLF UK in Martin. PIN was detected in 31 (6.4%) patients. Median age of patients with PIN was 67 years (range 58-75). There were 21 (68%) patients with low-grade PIN and 10 (32%) patients with high-grade PIN. In this group concomitant invasive cancer of the prostate was detected in 6 (19.4%) patients with PIN, of whom 5 (16.0%) had high-grade PIN and 1 (3.4%) nad low-grade PIN. Median concentration of PSA in patients with PIN was 9.1 ng/ml (range 1.3-85 ng/ml), significantly higher (p < 0.001) than PSA concentration in patients with BPH. We did not find significant differences between PSA concentrations in patients with PIN and in those with prostate cancer (p = 0.77). In conclusion we recommend clinical management of patients newly diagnosed with PIN.
authors.affiliation: Urologická klinika JLF UK, Martin, Slovenská republika.
authors.forename: B
authors.initials: B
authors.lastname: Eliás
authors.forename: J
authors.initials: J
authors.lastname: Kliment
authors.forename: J
authors.initials: J
authors.lastname: Svihra
authors.forename: A
authors.initials: A
authors.lastname: Kalis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D019048:Prostatic Intraepithelial Neoplasia / Q000175:diagnosis / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen
vernacular_title: Výskyt prostatickej intraepiteliálnej neoplázie v materiáli získanom punkcnou biopsiou prostaty a jej klinický význam.