[Radiation protective effect of beta-ketoanalogs of hydroxyphenyl ethanolamines].
Experiments are carried out on 3400 mice, irradiated in dose 8 Gy (LD97/30). beta-Ketoanalogs of adrenaline (adrenalone, 50-150 mumol/kg), m,p-dipivaloyladrenaline (20 mumol/kg) and phenylephrine (but at 2070 mumol/kg) have the high radioprotective effect (survival is 60-100%), beta-ketoanalogs of isoprenaline and m-benzoylphenylephrine have the middle RPE (50-60%). Their effective doses (except dipivaloyladrenalone) are considerably bigger (in 9-76 times), than beta-hydroxysubstances doses, but the toxicity of benzoylphenylephrone, dipivaloyladrenalone and especially adrenalone is by far lower (consequently in 3, 8, 2, 7 and 136 times). Therapeutic indexes of beta-ketosubstances achieve 35-100.
Kulinskiĭ
V I
VI
Irkutsk State Medical University, SPC Pharmzashchita, Himki, Russia.
Iashunskiĭ
V G
VG
Klimova
A D
AD
Alpatova
T V
TV
D000818:Animals; D004837:Epinephrine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010656:Phenylephrine / Q000494:pharmacology / Q000633:toxicity; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D010656:Phenylephrine; C015173:dipivefrin; C040224:adrenalone; D007545:Isoproterenol; D004837:Epinephrine
Radiozashchitnyĭ éffekt beta-ketoanalogov oksifenilétanolaminov.