Ecstasy-induced very severe aplastic anaemia complicated by invasive pulmonary mucormycosis treated with allogeneic peripheral blood progenitor cell transplant.
Very severe aplastic anaemia (vSAA) is rare. We report a case of Ecstasy-induced very severe aplastic anaemia which did not respond to immunosuppressive therapy, developing invasive pulmonary mucormycosis. The patient underwent an HLA-identical sibling peripheral blood progenitor cell transplant (PBPCT) with rapid neutrophil engraftment. During engraftment he developed life-threatening adult respiratory distress syndrome (ARDS). This case serves to illustrate a novel aetiology of vSAA where the infective complications responded to prompt haematopoietic engraftment.
Clark
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AD
Bone Marrow Transplant Unit, Glasgow Royal Infirmary University NHS Trust, UK.
Butt
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N
D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced*; D015198:Designer Drugs / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008172:Lung Diseases, Fungal / Q000209:etiology / Q000628:therapy*; D008297:Male; D009091:Mucormycosis / Q000209:etiology / Q000628:therapy*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000009:adverse effects*; D014184:Transplantation, Homologous
D015198:Designer Drugs; D018817:N-Methyl-3,4-methylenedioxyamphetamine