An evaluation of the markers p53 and Ki-67 for their predictive value in prostate cancer.
OBJECTIVE
p53 and Ki-67 are but two markers being evaluated for their predictive value in prostate cancer. The purpose of this study was to compare p53 and Ki-67 with age, stage, Gleason score, and ploidy for their prognostic abilities in prostate cancer.


METHODS
Prostate cancer specimens from 134 patients were immunohistochemically stained for p53 and Ki-67 expression and differences evaluated by SPSS analysis of variance (ANOVA) methods. The dependent variable was patient survival and the independent variables were age, stage, Gleason score, and ploidy.


RESULTS
In decreasing order of prediction of survival were stage (P < 0.001), Gleason score (P < 0.001), age (P = 0.1869), Ki-67 (P = 0.2284), p53 (P = 0.4282) and ploidy (P = 0.8141).


CONCLUSIONS
It is concluded that stage and Gleason score are significant predictors of survival while p53, Ki-67, age and ploidy are not.
Uzoaru
I
I
Division of Cellular Biology, Hektoen Institute for Medical Research, Chicago, IL 60612, USA.
Rubenstein
M
M
Mirochnik
Y
Y
Slobodskoy
L
L
Shaw
M
M
Guinan
P
P
D000368:Aged; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D011003:Ploidies; D011237:Predictive Value of Tests; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53