Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.
Fontecave
M
M
Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS-CEA/CNRS/Université Joseph Fourier, Grenoble, France. Fontecav@cbcrb.ceng.cea.fr
Lepoivre
M
M
Elleingand
E
E
Gerez
C
C
Guittet
O
O
D000818:Animals; D004273:DNA, Neoplasm; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005609:Free Radicals; D006801:Humans; D051379:Mice; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology*; D011993:Recombinant Fusion Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D000077185:Resveratrol; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors* / Q000235:genetics; D013267:Stilbenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000378:metabolism
D004273:DNA, Neoplasm; D004791:Enzyme Inhibitors; D005609:Free Radicals; D019384:Nucleic Acid Synthesis Inhibitors; D011993:Recombinant Fusion Proteins; D013267:Stilbenes; D014443:Tyrosine; D012264:Ribonucleotide Reductases; C108427:ribonucleotide reductase R2 subunit; D000077185:Resveratrol