Stereoselection in designed three-helix bundle metalloproteins.
The stereochemical consequences of the metal-ion assisted self-assembly of parallel three-helix peptide bundles are investigated. Chiral induction in the self-assembly of systems containing extensive protein secondary structure is compared with the racemic synthesis of short metallopeptides. Isolation and characterization of the individual stereoisomers of an exchange-inert metalloprotein provide structural insights into analogous exchange-labile systems.
Case
M A
MA
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Ghadiri
M R
MR
Mutz
M W
MW
McLendon
G L
GL
D002942:Circular Dichroism; D019277:Entropy; D007501:Iron / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008667:Metalloproteins / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011487:Protein Conformation; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
D008667:Metalloproteins; D010455:Peptides; D012428:Ruthenium; D007501:Iron