title: Potent free radical scavenging activity of propol isolated from Brazilian propolis.
abstract: We evaluated free radical scavenging activity of the water, methanol and chloroform extracts of propolis in 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and xanthine-xanthine oxidase (XOD) generated superoxide anion assay systems. The free radical scavenging activity guided fractionation and chemical analysis led to the isolation of a new compound, propol (3-[4-hydroxy-3-(3-oxo-but-1-enyl)-phenyl]-acrylic acid) from the water extract, which was more potent than most common antioxidants such as vitamin C and vitamin E (alpha-tocopherol) in these assay systems.
authors.affiliation: Pharmazeutisch-Chemisches Institut, Universität Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Basnet
authors.forename: T
authors.initials: T
authors.lastname: Matsuno
authors.forename: R
authors.initials: R
authors.lastname: Neidlein
mesh_terms: D000179:Acrylates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001938:Brazil; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005609:Free Radicals; D011429:Propolis / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: C110594:3-(4-hydroxy-3-(3-oxo-but-1-enyl)-phenyl)-acrylic acid; D000179:Acrylates; D016166:Free Radical Scavengers; D005609:Free Radicals; D013481:Superoxides; D019820:Xanthine; D011429:Propolis; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase