title: Semen parameters and testicular pathology in men with testicular cancer and contralateral carcinoma in situ or bilateral testicular malignancies.
abstract: We evaluated 14 patients with bilateral testicular tumour, one-sided tumour and contralateral carcinoma in situ (CIS) of the testis or testis tumour in single testis with respect to their fertility. We analysed semen parameters, serum hormones [follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone], testicular sonography, testicular volumes and testicular histology prior to further anti-cancer treatment. Ten out of 14 patients showed normal or reduced sperm concentrations, while 4/14 patients were azoospermic. Serum FSH levels showed a significant negative correlation with sperm concentrations in patients with testicular malignancies (r = -0.64, P = 0.025). Testicular volumes revealed a significant positive correlation with semen parameters in patients with testes that were affected by CIS (r = 0.733, P = 0.038). We conclude that even bilateral testicular cancer and/or CIS do not preclude fertility and, therefore, patients should be offered andrological investigation and therapy, including possibly surveillance strategy or the chance for cryopreservation of the semen prior to further treatment in order to preserve their chances for paternity.
authors.affiliation: Department of Urology, University of Münster, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Kliesch
authors.forename: M
authors.initials: M
authors.lastname: Bergmann
authors.forename: L
authors.initials: L
authors.lastname: Hertle
authors.forename: E
authors.initials: E
authors.lastname: Nieschlag
authors.forename: H M
authors.initials: HM
authors.lastname: Behre
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000097:blood / Q000150:complications / Q000473:pathology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000473:pathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D012661:Semen / Q000166:cytology*; D018239:Seminoma / Q000473:pathology; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000473:pathology; D013736:Testicular Neoplasms / Q000097:blood / Q000150:complications / Q000473:pathology*; D013737:Testis / Q000000981:diagnostic imaging / Q000473:pathology*; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone