[HLA antigens are associated in seronegativity to cytomegalovirus(CMV)].
Cytomegalovirus(CMV) is ubiquitous in the world, but the rate of CMV antibody positivity (seropositivity) in adults varies geographically. In Japan, CMV seropositivity in adults in 90% and we perceived seronegative adults tend to remain seronegative in 10 years follow up study. We have performed HLA typing 125 seronegative healthy donors of 28 years and up (28-57, Ave.35), and the results were compared with those of healthy donors in same area and whole Japan (data from 10th HLA workshop). Incidence of HLA-A33 and HLA-Cw4 were significantly higher in seronegatives than control groups. This report suggests possible involvement of HLA type in CMV negativity.
Machida
S
S
Department of Bacteriology, Saitama Medical School.
Takahashi
T
T
Nomoto
K
K
Murata
S
S
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology*; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis / Q000502:physiology; D015236:HLA-C Antigens / Q000032:analysis / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests
D000914:Antibodies, Viral; D015234:HLA-A Antigens; C082945:HLA-A*33 antigen; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen