[Anti Ko(a) as a cause of neonatal alloimmune thrombocytopenia].
Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal immunization against a paternal antigen on fetal platelets. The antigens mostly involved are Zwa (PlA1) and Br(a). The Ko alloantigen system which is localized on the N-terminal region of glycoprotein Ib usually causes antibody formation in polytransfused patients but is only rarely implicated in NAIT. Ko(a) antibodies raised in the mother of a thrombocytopenic newborn were shown to be detectable by platelet agglutination and MAIPA assay if the antigen-bearing N-terminal glycocalicin is protected from proteolytic degradation.
Kroll
H
H
Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen, Deutschland.
Muntean
W
W
Kiefel
V
V
Giptner
A
A
Schlüter
C
C
Santoso
S
S
Mueller-Eckhardt
C
C
D016824:Antigens, Human Platelet / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology; D011247:Pregnancy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*
C071221:2b alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies; D019038:Platelet Glycoprotein GPIb-IX Complex
Anti-Ko(a) als Ursache der neonatalen Alloimmunthrombozytopenie.