[Protein A immunoadsorption al a new apheresis procedure for elimination of HLA antibodies].
The protein A immunoadsorption allows to remove antibodies of the classes IgG, IgM and IgA in special quantities from the plasma. IgG subclasses 1, 2 and 4 will be removed for 100% and IgG of class 3 for nearly 80%. For this reason immunoadsorptions are a useful therapeutic method especially for immunological diseases with antibodies of IgG type. The successful use of immunoadsorption in the removal of HLA antibodies in patients with acute myeloic leukemia and patients after kidney allograft is reported.
Schneidewind
J
J
Klinik für Innere Medizin, Universität Rostock, Deutschland.
Gliesche
T
T
Sehland
D
D
Ramlow
W
W
Wolfsdorff
B
B
Bast
R
R
Wegener
S
S
Decker
S
S
Schmidt
R
R
D001803:Blood Transfusion; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood* / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000097:blood* / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000097:blood* / Q000302:isolation & purification; D007163:Immunosorbent Techniques; D007518:Isoantibodies / Q000096:biosynthesis* / Q000302:isolation & purification; D016030:Kidney Transplantation / Q000276:immunology* / Q000502:physiology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D013205:Staphylococcal Protein A; D014184:Transplantation, Homologous
D006680:HLA Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies; D013205:Staphylococcal Protein A
Die Protein-A-Immunadsorption als ein neues Aphereseverfahren zur Elimination von HLA-Antikörpern.