title: The UL6 locus of pseudorabies virus and its homology to oncogenic herpesviruses.
abstract: The UL6 locus of pseudorabies virus (PRV) was analyzed to reveal a gene cluster with homology to herpes simplex virus UL5, UL6, UL7 and UL8, Epstein-Barr virus BBRF1 and BBRF2, and Kaposi sarcoma-associated herpes virus ORF43 and ORF42. The noncoding region between PRV UL7 and UL8 contained 16 copies of a 14 bp T + C-rich repeat element. The mRNA start sites for UL6 and UL7 were mapped by primer extension and UL6 was expressed in vitro. The mobility of the in vitro-expressed UL6 protein correlated with the predicted mass of 66 kDa. The relationship and potential significance of the UL6 locus with the corresponding sequences in oncogenic herpesviruses is discussed.
authors.affiliation: Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, NC, 27858-4354, USA.
authors.forename: N E
authors.initials: NE
authors.lastname: Pederson
authors.forename: J T
authors.initials: JT
authors.lastname: Casey
authors.forename: K M
authors.initials: KM
authors.lastname: Koslowski
authors.forename: P R
authors.initials: PR
authors.lastname: Shaver
mesh_terms: D000818:Animals; D001483:Base Sequence; D002213:Capsid / Q000096:biosynthesis / Q000235:genetics*; D036022:Capsid Proteins; D002460:Cell Line; D017931:DNA Primers; D016679:Genome, Viral; D011558:Herpesvirus 1, Suid / Q000235:genetics*; D004854:Herpesvirus 4, Human / Q000235:genetics; D019288:Herpesvirus 8, Human / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D016366:Open Reading Frames; D014176:Protein Biosynthesis; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013552:Swine; D016385:TATA Box; D014158:Transcription, Genetic; D014764:Viral Proteins
chemical_list: D036022:Capsid Proteins; D017931:DNA Primers; D014764:Viral Proteins; C069185:DNA cleavage and packaging proteins, Herpesvirus