title: Development of a new kind of dual modulated QCM biosensor.
abstract: To distinguish the mass loading effect from the total frequency change is a problem in the application of a quartz crystal microbalance (QCM) biosensor in the liquid phase. Based on the characteristic damping theory, this paper proposes a new method of dual modulation to solve this problem. Using polyethyleneimine to immobilize anti-SE (staphylococcin enterotoxin) antibody (C2 type), a dual modulated QCM SE biosensor was developed and the experiment proved that it has little cross-reaction with B-type SE. The measuring curve of the sensor was also determined through experiment.
authors.affiliation: Department of Precision Instruments and Mechanology, Tsinghua University, Beijing, People's Republic of China.
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Feng
authors.forename: Z
authors.initials: Z
authors.lastname: Gao
mesh_terms: D015374:Biosensing Techniques; D004768:Enterotoxins / Q000032:analysis*; D011791:Quartz; D012680:Sensitivity and Specificity
chemical_list: D004768:Enterotoxins; D011791:Quartz; C031818:enterotoxin B, staphylococcal; C034959:enterotoxin C, staphylococcal