In vitro genotoxicity of polycyclic musk fragrances in the micronucleus test.
The synthetic polycyclic musk fragrance compounds galaxolide (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-(g)-2-b enzopyrane), tonalide (7-acetyl-1,1,3,4,4,6-hexamerthyltetraline), celestolide (4-acetyl-1,1-dimethyl-6-tert-butylindane), phantolide (6-acetyl-1,1,2,3,3,5-hexamethylindane), cashmeran (6,7-dihydro-1,1,2,3,3-pentamethyl-4-(5H) indanone) and traseolide (5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane) were examined for their genotoxicity in the micronucleus test (MNT) with human lymphocytes in vitro in the presence and absence of an exogenous metabolizing system containing rat liver S9 and the metabolically competent human hepatoma cell line Hep G2. Compound concentrations were employed up to cytotoxic doses. Galaxolide, tonalide, celestolide, phantolide, cashmeran and traseolide revealed no genotoxicity in the micronucleus test with human lymphocytes and with the human hepatoma cell line Hep G2.
Kevekordes
S
S
Medical Institute of General Hygiene and Environmental Health, University of Göttingen, Germany.
Mersch-Sundermann
V
V
Diez
M
M
Dunkelberg
H
H
D000328:Adult; D000818:Animals; D001578:Benzopyrans / Q000633:toxicity; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D005229:Fatty Acids, Monounsaturated / Q000633:toxicity*; D006801:Humans; D007189:Indans / Q000633:toxicity; D008214:Lymphocytes / Q000187:drug effects; D015162:Micronucleus Tests; D010476:Perfume / Q000633:toxicity*; D051381:Rats; D013764:Tetrahydronaphthalenes / Q000633:toxicity; D014407:Tumor Cells, Cultured
C110695:5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane; D001578:Benzopyrans; D005229:Fatty Acids, Monounsaturated; D007189:Indans; D010476:Perfume; D013764:Tetrahydronaphthalenes; C008563:musk; C033118:acetyl tert-butyl dimethylindan; C033119:galaxolide; C033117:phantolid; C033116:acetyl methyl tetramethyl tetralin; C110694:6,7-dihydro-1,1,2,3,3-pentamethyl-4-(5H)indanone