title: Untreated cervical infections, chorioamnionitis and prematurity.
abstract: OBJECTIVE
  To examine the relationship of endocervical pathogens and cervicitis with the development of chorioamnionitis, premature rupture of membranes (PROM) and prematurity.
  
  
  METHODS
  Three groups of pregnant women were included in the study: group A, controls with no evidence of cervicitis; group B, women with cervicitis due to pathogenic bacteria, who had been treated; and group C, women with untreated cervicitis who had not followed the prescribed therapy. Endocervical samples were cultured and aerobic and anaerobic bacteria isolated to examine the correlation of cervicitis with chorioamnionitis, PROM and prematurity.
  
  
  RESULTS
  There was a significantly higher incidence of prematurity in women with untreated cervicitis (group C). Mixed endocervical pathogens were most often involved (36.3%). A significantly higher number of endocervical pathogens were isolated in cases of chorioamnionitis (P < 0.001). Prematurity was seen in 39.6% of cases of chorioamnionitis. Prematurity was also more common in women with PROM (42.1%) than in those with intact membranes (11.8%).
  
  
  CONCLUSIONS
  It is concluded that untreated endocervical infections are an etiological factor of chorioamnionitis, PROM and prematurity.
authors.affiliation: 1st Department of Obstetrics and Gynecology, University of Athens, Alexandra Hospital, Greece.
authors.forename: G C
authors.initials: GC
authors.lastname: Creatsas
authors.forename: V M
authors.initials: VM
authors.lastname: Charalambidis
authors.forename: E
authors.initials: E
authors.lastname: Zagotzidou
authors.forename: D I
authors.initials: DI
authors.lastname: Aravantinos
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002821:Chorioamnionitis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D015994:Incidence; D007234:Infant, Premature; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000382:microbiology; D011256:Pregnancy Outcome; D002575:Uterine Cervicitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents