Increased CD5+CD19+ B lymphocytes at the onset of type 1 diabetes in children.
The aim of this study was to determine whether the proportion of circulating B cells expressing the differentiative antigen CD5 was increased in children affected by type 1 diabetes, and whether the number of these cells was correlated with the presence of anti-islet cell autoantibodies. Sixteen children affected by insulin-dependent diabetes mellitus (type 1) were investigated for the presence of B lymphocytes bearing the CD5 surface molecule, T-cell-specific activation markers, organ- and nonorgan-specific autoantibodies. The number of CD5+CD19+ cells was higher in type 1 children with a very recent onset of the disease, as compared with patients on insulin therapy for more than 30 days and controls (P < 0.05). No correlation was found between the number of CD5+CD19+ cells and the presence of either organ- or nonorgan-specific autoantibodies. Our results indicate that CD5+CD19+ cells are involved in the pathogenesis of type 1 diabetes in children. A potential immunoregulatory role of this B cell population is discussed.
De Filippo
G
G
Department of Pediatrics, Federico II University, Naples, Italy.
Pozzi
N
N
Cosentini
E
E
Cavalcanti
M
M
Carel
J C
JC
Tamasi
S
S
Franzese
A
A
Pignata
C
C
D017668:Age of Onset; D018941:Antigens, CD19 / Q000276:immunology* / Q000378:metabolism; D016175:B-Lymphocyte Subsets / Q000145:classification / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D018956:CD5 Antigens / Q000276:immunology* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D012016:Reference Values
D018941:Antigens, CD19; D015415:Biomarkers; D018956:CD5 Antigens