A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer cells.
In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2,3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1 beta,2 beta-diacetoxy-6 alpha,9 alpha-bis(benzoyloxy)dihydro-beta-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.
Kim
S E
SE
Natural Product & Biosynthesis Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.
Kim
Y H
YH
Lee
J J
JJ
Kim
Y C
YC
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000502:physiology; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D006801:Humans; D012717:Sesquiterpenes; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C110798:1,2-diacetoxy-6,9-bis(benzoyloxy)dihydro-beta-agarofuran; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D014315:Triterpenes