Distribution of the alpha7 nicotinic acetylcholine receptor subunit in the developing chick cerebellum
Previous studies of the nicotinic acetylcholine receptor (nAChR) subunits in adult mammalian and avian brains have demonstrated a spatially restricted distribution of these subunits; little, however, is known about the nAChR subunit developmental distribution. The present study demonstrated a transient pattern of distribution of the neuronal nAChR subunit, alpha7, in the developing chick cerebellum by using immunohistochemical techniques. This transient distribution may suggest a critical period for the development of the cholinergic system in the cerebellum.
Kaneko
WM
Department of Neurosciences-0608, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0608, USA
Britto
LRG
Lindstrom
JM
Karten
HJ