Translocation (X;1) reveals metastasis 31 years after renal cell carcinoma.
Cytogenetic investigation of a metastatic lesion appearing 31 years after nephrectomy allowed for the diagnosis of a renal cell carcinoma. The der(X)t(X;1)(p11.2;q21.1) found in this case and review of the 14 other cases previously reported indicates that this chromosome lesion may characterize a specific subgroup of renal cell carcinoma, with distinct histology and age distribution that also can occur in females.
Dal Cin
P
P
Center for Human Genetics, Leuven, Belgium.
Stas
M
M
Sciot
R
R
De Wever
I
I
Van Damme
B
B
Van den Berghe
H
H
D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology*; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D014178:Translocation, Genetic; D014960:X Chromosome