[Effect of zinc-metallothionein on DNA replicative synthesis and single-stranded DNA-binding protein (SSB-protein) content in chromatin of mice bone marrow cells].
It was shown that the incubation in vitro of mice bone marrow cells with rat hepatic zinc-metallothionein (10-138 micrograms per 10(7) nuclear cells) leads to simultaneous 1.2-1.4 fold increase of DNA replicative synthesis level and 1.2-3 fold increase of the content of single-stranded DNA-binding proteins in chromatin of nuclear cells. Possible mechanisms of these effects connected with zinc ions donation and the increase of the content of DNA with single-stranded regions were discussed.
Koterov
A N
AN
D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism*; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism*; D008668:Metallothionein / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D015032:Zinc
D002843:Chromatin; D004268:DNA-Binding Proteins; C021267:zinc thionein; D008668:Metallothionein; D015032:Zinc
Vliianie tsink-metallotioneina na replikativnyĭ sintez DNK i soderzhanie belkov, sviazyvaiushchikhsia s odnonitevoĭ DNK (belki SSB) v khromatine kletok kostnogo mozga mysheĭ.