Depression in classic versus akinetic-rigid Parkinson's disease.
We examined the prevalence of major depression and dysthymia in 78 patients with the classic variant of Parkinson's disease (PD) (that is, tremor plus rigidity and/or bradykinesia), and in 34 patients with the akinetic-rigid variant. Although the prevalence of dysthymia was similar in both groups (classic PD, 31%; and akinetic-rigid PD, 32%), patients with akinetic-rigid PD had a significantly higher prevalence of major depression (38% versus 15%, respectively; p < 0.01). A stepwise regression analysis demonstrated that bradykinesia was the extrapyramidal sign with the highest correlation with Hamilton depression scale scores. Our findings demonstrate a significant association between major depression and the akinetic-rigid type of PD.
Starkstein
S E
SE
Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
Petracca
G
G
Chemerinski
E
E
Tesón
A
A
Sabe
L
L
Merello
M
M
Leiguarda
R
R
D000368:Aged; D016009:Chi-Square Distribution; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology*; D003866:Depressive Disorder / Q000453:epidemiology*; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000453:epidemiology; D010300:Parkinson Disease / Q000145:classification / Q000453:epidemiology*; D015995:Prevalence; D014202:Tremor / Q000453:epidemiology