title: [Changes in clinical and epidemiologic characteristics in Western Bohemia of invasive meningococcal disease associated with the occurrence of an invasive clone of Neisseria meningitidis].
abstract: The authors analyzed the incidence of meningococcal diseases in the West Bohemian region in 1982-1996. The draw attention to changes of clinical and epidemiological characteristics of the disease which appeared in 1994 in conjunction with a new invasive clonus of Neisseria meningitidis C:2a:P1.2, P1.5, ET-15/37. While in 1982-1993 invasive meningococcal diseases had in 75% the course of meningitis with a relatively low fatality (4%), during the subsequent period a marked change occurred. Since 1994 the disease took in the West Bohemian region in 58% the course of sepsis with a fatality of 16%. 25% cases of meningococcal meningitis were diagnosed combined sepsis and meningitis in 17%. The disease lost its seasonal character and the authors confirmed the highest incidence of the disease in the age group from 15-19 years and 0-4 years. Neisseria meningitidis group C was detected in 1994-1996 in 73% and the invasive clone C:2a:P1.2, P1.5, ET-15/37 in 62%.
authors.affiliation: Infekcní klinika, Fakultní nemocnice, Plzen.
authors.forename: V
authors.initials: V
authors.lastname: Struncová
authors.forename: P
authors.initials: P
authors.lastname: Pazdiora
authors.forename: M
authors.initials: M
authors.lastname: Valchová
authors.forename: D
authors.initials: D
authors.lastname: Sedlácek
authors.forename: D
authors.initials: D
authors.lastname: Fránová
authors.forename: R
authors.initials: R
authors.lastname: Bárta
authors.forename: M
authors.initials: M
authors.lastname: Musílek
authors.forename: P
authors.initials: P
authors.lastname: Krízová
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018153:Czech Republic / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D008875:Middle Aged; D009345:Neisseria meningitidis / Q000472:pathogenicity*
vernacular_title: Zmĕny klinických a epidemiologických charakteristik invazivního meningokokového onemocnĕní v západních Cechách v souvislosti s výskytem invazivního klonu Neisseria meningitidis.