[Effect of the angiotensin-converting enzyme inhibitor ramipril on the processes of lipid peroxidation on the status of the endogenous antioxidant system in patients with myocardial infarction].
57 patients with macrofocal through-and-through myocardial infarction (MI) formed two groups. The control one (37 patients) received conventional treatment and the study one (20 patients) received adjuvant ramipril beginning from day 1 of MI and over the observation period. The patients were examined on day 1, 3, 10 and 20 from the moment of admission. MI patients of all the studied groups exhibited high level of lipid peroxidation (LP) products in the serum. Ramipril treatment produced marked correcting influence on conjugated dienes, malonic dialdehyde and degree of lipid oxidation. In MI patients on ramipril conjugated dienes level was the lowest on MI day 1-3, and malonic dialdehyde on MI day 10-20. Ramipril treatment limited alpha-tocopherol and ceruloplasmin increase in the serum. It is shown that in the mechanism of a positive effect of angiotensin-converting enzyme inhibitors in MI not only their direct pharmacological action can be involved but also a correction of LP processes and antioxidant system disturbances.
Davydov
B V
BV
Golikov
P P
PP
Marchenko
V V
VV
Riabinin
V A
VA
Golikov
A P
AP
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D017257:Ramipril / Q000627:therapeutic use*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D017257:Ramipril
Vliianie ingibitora angiotenzin-prevrashchaiushchego fermenta ramiprila na protsessy perekisnogo okiseleniia lipidov i sostoianie éndogennoĭ antioksidantnoĭ sistemy u bol'nykh s infarktom miokarda.