Immature teratoma of the pineal gland with isochromosome 12p.
An immature teratoma arising in the pineal gland in a 27-year-old male was shown to present an isochromosome 12p as evidenced by cytogenetic and fluorescence in situ hybridization analysis. As i(12p) is characteristic of gonadal germ cell tumors, this case indicates that similar genetic pathways may operate in gonadal and intracranial teratomas.
Dal Cin
P
P
Center for Human Genetics, University of Leuven, Belgium.
Dei Tos
A P
AP
Qi
H
H
Giannini
C
C
Furlanetto
A
A
Longatti
P L
PL
Marynen
P
P
Van den Berghe
H
H
D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology*; D002881:Chromosomes, Human, Pair 12 / Q000502:physiology / Q000648:ultrastructure; D003582:Cytogenetics; D018237:Germinoma / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D018404:Isochromosomes / Q000502:physiology*; D008297:Male; D008677:Metaphase; D010870:Pineal Gland / Q000473:pathology* / Q000648:ultrastructure; D013724:Teratoma / Q000473:pathology*