Enhancement of the effect of an angiogenesis inhibitor on murine tumors by hyperthermia.
We investigated the effect of angiogenesis inhibitors (FR118487 and TNP-470) on two murine tumors (FM3A and SCC-VII) with and without hyperthermia. When angiogenesis inhibitors were administered immediately after tumor implantations there was no tumor growth. As the tumor diameter increased, the antitumor effect of the inhibitors decreased. When FR118487 was combined with hyperthermia, the antitumor effect was potentiated. This study suggested that angiogenesis inhibitors show their maximal effect against small tumors and have increased activity when combined with hyperthermia.
Ikeda
S
S
Department of Radiology, Kansai Medical University, 10-15 Fumizono-chou, Moriguchi-city, Osaka 570, Japan.
Akagi
K
K
Shiraishi
T
T
Tanaka
Y
Y
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D002455:Cell Division / Q000187:drug effects; D003131:Combined Modality Therapy; D003510:Cyclohexanes; D005260:Female; D006979:Hyperthermia, Induced; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D012717:Sesquiterpenes / Q000627:therapeutic use*; D013141:Spiro Compounds / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D003510:Cyclohexanes; C096036:FR 118487; D012717:Sesquiterpenes; D013141:Spiro Compounds; D000077609:O-(Chloroacetylcarbamoyl)fumagillol