[Aortic stop flow and hypoxic perfusion chemotherapy for unresectable gallbladder cancer].
We performed the aortic stop flow and hypoxic perfusion chemotherapy for unresectable gallbladder cancer under general anesthesia and made the perfusion only in the abdominal cavity by clamping the abdominal aorta and inferior vena cava near the site of diaphragma. Although temporary hypertension occurred just after clamping the aorta, no severe problem could be seen during operation. After surgery the patient had no abnormalities such as liver or kidney dysfunction, and tumor markers gradually came to decrease. Furthermore, the effectiveness of this therapy is greatly anticipated for the unresectable abdominal cancer, evaluating the selection of anti-cancer drugs and their administration dosage etc.
Aoki
T
T
Dept. of Surgery, Tokyo Medical College.
Tsuchida
A
A
Aoki
T
T
Asami
K
K
Uda
O
O
Inoue
K
K
Masuhara
S
S
Kasuya
K
K
Ozawa
T
T
Koyanagi
Y
Y
D000768:Anesthesia, General; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001012:Aorta, Abdominal; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D005472:Fluorouracil / Q000008:administration & dosage; D005706:Gallbladder Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D010100:Oxygen / Q000502:physiology
D016685:Mitomycin; D010100:Oxygen; D005472:Fluorouracil