Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114.
A perchloric acid-soluble protein extracted from goat liver and designated as UK 114 is known to be expressed over the cell membrane of (some) human cancer cell lines. This protein is antigenic, and specific antibodies elicit complement-dependent cytolysis of neoplastic target cells. In this study we demonstrate that administration of UK 114, either pure or as a crude extract (designated UK 101), inhibits the growth of mammary carcinomas induced in female Sprague-Dawley rats by dimethylbenzanthracene (DMBA). The mechanism of the tumour inhibitory activity of UK 114 is probably related to induction of immunosurveillance.
Racca
S
S
Department of Biological and Clinical Sciences, University of Turin, Italy.
Di Carlo
F
F
Bartorelli
A
A
Bussolati
B
B
Bussolati
G
G
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000951:Antigens, Neoplasm / Q000378:metabolism; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006041:Goats; D008099:Liver / Q000737:chemistry*; D015674:Mammary Neoplasms, Animal / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011506:Proteins / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000951:Antigens, Neoplasm; D011506:Proteins; D015127:9,10-Dimethyl-1,2-benzanthracene; D003165:Complement System Proteins