title: Echinococcus granulosus myophilin--relationship with protein homologues containing "calponin-motifs".
abstract: Myophilin, a smooth-muscle protein of the tapeworm Echinococcus granulosus, was recently postulated to be a member of the calponin family of proteins. A detailed genetic analysis revealed that 17 proteins had significant homology with the amino-acid sequence of the N-terminal region of myophilin and/or possessed one or more "calponin-motifs". Comparison of the amino-acid sequences of the N-terminus showed that the homologous proteins clustered into distinct groups based on the number of calponin-motifs. The calponin-motif of myophilin was genetically more similar to that present in the muscle protein mp20 of Drosophila melanogaster than to those in any other homologous proteins of vertebrates. The existence of a distinct motif which is "conserved" in other proteins across a range of species suggests an important functional role for the motif.
authors.affiliation: Department of Veterinary Science, University of Melbourne, Werribee, Victoria, Australia.
authors.forename: R M
authors.initials: RM
authors.lastname: Martin
authors.forename: N B
authors.initials: NB
authors.lastname: Chilton
authors.forename: M W
authors.initials: MW
authors.lastname: Lightowlers
authors.forename: R B
authors.initials: RB
authors.lastname: Gasser
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics; D004446:Echinococcus / Q000737:chemistry* / Q000235:genetics*; D015801:Helminth Proteins / Q000737:chemistry* / Q000235:genetics*; D008840:Microfilament Proteins; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000737:chemistry* / Q000235:genetics*; D009130:Muscle, Smooth / Q000737:chemistry; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D000096985:Calponins
chemical_list: D000947:Antigens, Helminth; D002135:Calcium-Binding Proteins; D015801:Helminth Proteins; D008840:Microfilament Proteins; D009124:Muscle Proteins; D000096985:Calponins; C095050:myophilin protein, Echinococcus granulosus