C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells.
We report the cloning and characterization of a novel cDNA termed C2H2-546 which encodes a C2H2-type zinc finger protein. C2H2-546 RNA is expressed in the HTLV-1 infected T cells examined which were derived from HAM-TSP patients, but not in T cells derived from ATL patients. The C2H2-546 gene is conserved in humans and primates and maps to chromosome 10q11.2, a site associated with a variety of cancers. Thus, C2H2-546 is a candidate regulatory molecule important in the formation of these tumors, and may serve as an important marker to distinguish HTLV-1 infected ATL versus HAM-TSP T cell lineages.
Drew
P D
PD
Neuroimmunology Branch, NCHGR National Institutes of Health, Bethesda, Maryland 20892, USA.
Gado
A M
AM
Canning
R D
RD
Nagle
J W
JW
Dehejia
A M
AM
Polymeropoulos
M H
MH
Biddison
W E
WE
Jacobson
S
S
Becker
K G
KG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018244:Chromosomes, Artificial, Yeast; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D005796:Genes; D015490:HTLV-I Infections / Q000235:genetics*; D015368:Human T-lymphotropic virus 1 / Q000502:physiology*; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000473:pathology; D008322:Mammals / Q000235:genetics; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D009687:Nuclear Proteins; D015493:Paraparesis, Tropical Spastic / Q000235:genetics / Q000473:pathology; D016133:Polymerase Chain Reaction; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013045:Species Specificity; D013601:T-Lymphocytes / Q000378:metabolism* / Q000821:virology; D014157:Transcription Factors; D014407:Tumor Cells, Cultured; D016335:Zinc Fingers / Q000235:genetics*
D018076:DNA, Complementary; D051741:Kruppel-Like Transcription Factors; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C111477:ZNF32 protein, human