Reduced Loa loa microfilaria count ten to twelve months after a single dose of ivermectin.
The action of a single dose of ivermectin (200 micrograms/kg) on 71 Gabonese patients with Loa loa microfilariae in the peripheral blood, and living in areas highly endemic for loiasis, has been evaluated. Ten to 12 months after treatment, 43 patients (63%) had no circulating microfilaria and the geometric mean peripheral blood microfilaria count had decreased by 88.6% (P < 0.02). Thus, a single annual dose of ivermectin can markedly reduce loiasis transmission.
Duong
T H
TH
Faculté de Médecine, Tours, France.
Kombila
M
M
Ferrer
A
A
Bureau
P
P
Gaxotte
P
P
Richard-Lenoble
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005681:Gabon; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use*; D008117:Loa / Q000187:drug effects*; D008118:Loiasis / Q000188:drug therapy*; D008297:Male; D008842:Microfilariae / Q000187:drug effects; D008875:Middle Aged
D000969:Antinematodal Agents; D007559:Ivermectin