Magnesium lithospermate B ameliorates cisplatin-induced injury in cultured renal epithelial cells.
A study was conducted to clarify whether magnesium lithospermate B ameliorates cisplatin-induced renal injury in terms of lactate dehydrogenase and malondialdehyde leakage from LLC-PK1 cells in culture. Magnesium lithospermate B was shown to suppress the cytotoxicity of cisplatin, the suppressive effect increasing with the dose of magnesium lithospermate B.
Yokozawa
T
T
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Dong
E
E
Oura
H
H
Nonaka
G
G
Nishioka
I
I
D000818:Animals; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000633:toxicity*; D003404:Creatinine / Q000037:antagonists & inhibitors; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism; D006146:Guanidines / Q000037:antagonists & inhibitors; D007668:Kidney / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D018374:LLC-PK1 Cells; D008760:Methylguanidine / Q000037:antagonists & inhibitors; D013386:Succinates / Q000037:antagonists & inhibitors; D013552:Swine
D004365:Drugs, Chinese Herbal; D006146:Guanidines; D013386:Succinates; C061091:lithospermate B; D008760:Methylguanidine; C001318:guanidinosuccinic acid; D003404:Creatinine; D002945:Cisplatin