Spatial fluctuation of regional myocardial blood flows.
Digital radiography (100 pixels/mm2) combined with the technique of 3H-labeled desmethylimipramine deposition was employed to visualize regional blood flow distributions in rabbit left ventricular myocardium. A fluctuated pattern of myocardial flow and its dependence on arterial oxygen tension (PaO2) was evaluated with the coefficient of variation (CV) computed at each step of coarse-graining; flow images were revisualized by increasing pixel area (PA) step by step from 0.01 to 1 mm2. The CV values decreased with hypoxia at all resolution levels, suggesting that there is a vascular regulatory mechanism for making myocardial perfusion uniform in response to decreased PaO2. In both perfusion states, CV decreased with increasing PA. The relationship between CV and PA fitted the noninteger power law function, implying an apparent fractality of CV.
Matsumoto
T
T
Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan. matsumoto@me.kawasaki-m.ac.jp
Ebata
J
J
Tsujioka
K
K
Ogasawara
Y
Y
Kajiya
F
F
D000818:Animals; D003326:Coronary Circulation; D003891:Desipramine; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D000860:Hypoxia / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D011817:Rabbits; D011856:Radiographic Image Enhancement; D014316:Tritium
D014316:Tritium; D010100:Oxygen; D003891:Desipramine