title: Helium versus oxygen for tracheal gas insufflation during mechanical ventilation.
abstract: OBJECTIVE
  To evaluate and compare the effect of tracheal gas insufflation using two gases with different physical properties, helium and oxygen, as an adjunct to conventional mechanical ventilation in patients with respiratory failure.
  
  
  METHODS
  Prospective, intervention study.
  
  
  METHODS
  General intensive care unit in a tertiary university medical center.
  
  
  METHODS
  Seven sedated and paralyzed patients with respiratory failure of various etiologies. All patients were ventilated in the volume-control mode (tidal volume 5 to 7 mL/kg). Inclusion criteria were PaCO2 of > or =50 torr (> or =6.7 kPa), together with peak inspiratory pressure of > or =35 cm H2O and respiratory rate of > or =14 breaths/min.
  
  
  METHODS
  All patients were intubated with an endotracheal tube that had an additional lumen opening at its distal end, through which tracheal gas insufflation was administered. The tracheal gas insufflation was applied continuously throughout the respiratory cycle at three flow rates (2, 4, and 6 L/min) with two gases, oxygen and helium, while the ventilatory settings were maintained constant.
  
  
  RESULTS
  In addition to airway pressures and arterial blood gases, the relative efficacy of tracheal gas insufflation with each gas was estimated using a "coefficient of efficiency" (which we defined as the change in PaCO2/peak inspiratory pressure) compared with baseline measurements. Tracheal gas insufflation with both gases decreased PaCO2 significantly (p < .05) at all flow rates. This effect was accompanied by an increase in airway pressure with both gases (oxygen and helium). However, at flow rates of 6 L/min, tracheal gas insufflation with helium resulted in lower peak inspiratory pressure than with oxygen. Tracheal gas insufflation with helium was more effective (as estimated by the coefficient of efficiency) than with oxygen at all flow rates (p < .05).
  
  
  CONCLUSIONS
  In volume-controlled, mechanically ventilated patients with respiratory failure, tracheal gas insufflation with helium might be suggested as an alternative to oxygen.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Hadassah-Hebrew University Hospital, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Pizov
authors.forename: A
authors.initials: A
authors.lastname: Oppenheim
authors.forename: L A
authors.initials: LA
authors.lastname: Eidelman
authors.forename: Y G
authors.initials: YG
authors.lastname: Weiss
authors.forename: C L
authors.initials: CL
authors.lastname: Sprung
authors.forename: S
authors.initials: S
authors.lastname: Cotev
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D005069:Evaluation Studies as Topic; D005260:Female; D006371:Helium / Q000008:administration & dosage*; D006801:Humans; D007327:Insufflation / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage*; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods* / Q000706:statistics & numerical data; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000628:therapy; D018709:Statistics, Nonparametric; D014132:Trachea
chemical_list: D006371:Helium; D010100:Oxygen