Expressions of E-cadherin and alpha- and beta-catenin mRNAs in uterine endometrial cancers.
To know the biological function of the adherens junction associated with histological dedifferentiation, intramuscular invasion, and clinical staging, we studied the expressions of E-cadherin and alpha- and beta-catenin mRNAs in endometrial cancers in comparison with those in normal uterine counterparts. As dedifferentiation, myometrial invasion and staging advanced, the expressions of E-cadherin and beta-catenin mRNAs decreased. This suggests that the function of adhesive molecules in the adherens junction might be disturbed, leading to invasiveness and metastatic potential.
Fujimoto
J
J
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Ichigo
S
S
Hori
M
M
Tamaya
T
T
D000328:Adult; D000368:Aged; D015820:Cadherins / Q000096:biosynthesis*; D003598:Cytoskeletal Proteins / Q000096:biosynthesis; D015536:Down-Regulation; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D016133:Polymerase Chain Reaction; D015534:Trans-Activators; D014158:Transcription, Genetic; D051178:alpha Catenin; D051176:beta Catenin
C495273:CTNNA1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin