[Spontaneous abortion of male fetuses with incontinentia pigmenti (apropos of a family)].
We report a family with incontinentia pigmenti. One affected woman had seven pregnancies, seven miscarriages; a prenatal diagnosis by molecular biology was undertaken in the last four cases (two males, two females). In the last two males, a miscarriage occurred at the beginning of the second trimester with cystic hygroma in a case. In the first two males a miscarriage was observed also at the beginning of the second trimester after chorionic biopsy or amniocentesis. These two miscarriages would not be a complication of prenatal diagnosis but spontaneous abortion of an affected male. The date of the miscarriage of affected males (the beginning of the second trimester) and the role of a cystic hygroma for the diagnosis of incontinentia pigmenti in this mother of a fetus karyotyped 46,XY are discussed.
Odent
S
S
Unité de Médecine Foetale, Hôpital Pontchaillou, Rennes.
Le Marec
B
B
Smahi
A
A
Hors-Cayla
C
C
Milon
J
J
Jouan
H
H
Laurent
M C
MC
Borg
A M
AM
D000028:Abortion, Induced; D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D000649:Amniocentesis; D015193:Chorionic Villi Sampling; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000235:genetics; D005865:Gestational Age; D006801:Humans; D007184:Incontinentia Pigmenti / Q000000981:diagnostic imaging / Q000235:genetics*; D007621:Karyotyping; D018191:Lymphangioma, Cystic / Q000000981:diagnostic imaging / Q000235:genetics; D008297:Male; D008967:Molecular Biology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012737:Sex Factors; D016216:Ultrasonography, Prenatal
L'interruption spontanée des grossesses de foetus mâles atteints dans l'incontinentia pigmenti (a propos d'une famille).