Chromatin remodeling machines: similar motors, ulterior motives.
Chromatin is a dynamic material; chromatin structures can repress transcription and their remodeling accompanies activation. Recent biochemical studies in Drosophila have revealed three multi-protein complexes with ATP-dependent chromatin restructuring activities. Although all contain the ATPase ISWI, their properties in vitro are markedly different, distinct from SWI-SNF and reveal intriguing connections to both transcription and chromatin assembly.
Cairns
B R
BR
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. cairns@rascal.med.harvard.edu
D000251:Adenosine Triphosphatases / Q000502:physiology; D000818:Animals; D002843:Chromatin / Q000502:physiology*; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D014157:Transcription Factors / Q000502:physiology
D002843:Chromatin; C086468:ISWI protein; D014157:Transcription Factors; D000251:Adenosine Triphosphatases