title: In vitro synthesis of prostaglandin E2 by synovial tissue after helium-neon laser radiation in rheumatoid arthritis.
abstract: This paper reports the effect of helium-neon laser radiation (power of 5 mW and 632.8 nm wave length) on the synthesis of PGE2 in vitro in synovial tissue of biopsy samples of knee joints in patients with chronic rheumatoid arthritis stages II or III. Twelve patients were studied. Each patient received 15 applications of He-Ne laser. Eleven points for He-Ne laser applications were selected in one of the affected knees. The energy density used was 8 J/cm2 per application point. The He-Ne laser therapy reduced the synthesis of PGE2. The analysis of the data revealed a statistically significant difference between the levels of the synthesis of PGE2 before treatment (17.69 +/- 2.65 ng mg-1 of dry tissue h-1) and after treatment (13.85 +/- 2.73 ng mg-1 of dry tissue h-1), with p < 0.01 comparing mean values. This was also accompanied by relief of pain (91.6%), and a favorable subjective report from the patient. We conclude that PGE2 is a quantifiable parameter that could explain what causes pain relief in patients with rheumatoid arthritis that are treated with He-Ne laser.
authors.affiliation: Servicio de Reumatología, Hospital Nacional de Clinicas, Córdoba, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Barberis
authors.forename: S
authors.initials: S
authors.lastname: Gamron
authors.forename: G
authors.initials: G
authors.lastname: Acevedo
authors.forename: I
authors.initials: I
authors.lastname: Cadile
authors.forename: H
authors.initials: H
authors.lastname: Juri
authors.forename: V
authors.initials: V
authors.lastname: Campana
authors.forename: A
authors.initials: A
authors.lastname: Castel
authors.forename: C M
authors.initials: CM
authors.lastname: Onetti
authors.forename: J A
authors.initials: JA
authors.lastname: Palma
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000378:metabolism* / Q000532:radiotherapy*; D015232:Dinoprostone / Q000096:biosynthesis*; D005260:Female; D006371:Helium; D006801:Humans; D007719:Knee Joint; D053685:Laser Therapy; D008875:Middle Aged; D009356:Neon; D010146:Pain / Q000209:etiology / Q000532:radiotherapy*; D013583:Synovial Membrane / Q000378:metabolism / Q000528:radiation effects*
chemical_list: D006371:Helium; D009356:Neon; D015232:Dinoprostone