title: Time course of myocardial viability after acute myocardial infarction: an echocardiographic study.
abstract: The recognition of dysfunctional but viable myocardium after acute myocardial infarction (MI) may be of importance for both patient prognostication and the decision for revascularization. Low-dose dobutamine echocardiography (LDDE) has been shown to be a reliable technique in detecting reversibility of dysfunctional myocardium. The aim of the present study was to assess by LDDE possible time-dependent changes in myocardial viability and to evaluate the value of LDDE used in the postinfarction period. Twenty-seven patients with acute MI underwent LDDE on day 6, 30, and 90. At LDDE day 6, 41% of the affected segments showed a positive response to LDDE. At later examination on day 30 and 90, only 32% and 18%, respectively, of the dysfunctioning segments responded to dobutamine stimulation, with a significant decline in response (p < 0.0001), indicating loss of viability. Spontaneous segmental outcome was significantly better for LDDE-responding segments than for nonresponding segments (p = 0.0001). This study indicated that myocardial viability may be temporary and that a time-dependent loss of viability may take place during the first months after MI.
authors.affiliation: Department of Medicine and Cardiology, Aarhus University, Denmark.
authors.forename: A S
authors.initials: AS
authors.lastname: Knudsen
authors.forename: A Z
authors.initials: AZ
authors.lastname: Darwish
authors.forename: A
authors.initials: A
authors.lastname: Nørgaard
authors.forename: O
authors.initials: O
authors.lastname: Gøtzsche
authors.forename: K
authors.initials: K
authors.lastname: Thygesen
mesh_terms: D004280:Dobutamine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D013997:Time Factors; D014463:Ultrasonography
chemical_list: D004280:Dobutamine