title: Association between IgE antibody against soluble egg antigen and resistance to reinfection with Schistosoma japonicum.
abstract: There is evidence that immunoglobulin (Ig) E antibody may be a critical component of protective immunity against Schistosoma mansoni and S. haematobium reinfection. In the present study, 555 individuals aged 3-67 years infected with S.japonicum received praziquantel treatment before the transmission season commenced; 45 d later, blood samples from 265 individuals who had no S. japonicum egg in their stool were examined by enzyme-linked immunosorbent assay for specific isotypic antibodies. Single, non-conditional logistic regression analysis showed that exposure intensity, age, soluble egg antigen (SEA)-IgE, SEA-IgM and soluble adult worm antigen-IgG4 were relevant to reinfection; multiple, non-conditional logistic regression analysis showed that exposure intensity was still a significant factor for reinfection while the SEA-IgE antibody level was associated with resistance to reinfection with S. japonicum, with a protective index of 2.00. It is suggested that this population in an area endemic for schistosomiasis japonica exhibits acquired immunity.
authors.affiliation: Molecular and Immunoparasitology Research Department, Nanjing Medical University, Nanjing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Hu
authors.forename: Z
authors.initials: Z
authors.lastname: Xie
authors.forename: Y
authors.initials: Y
authors.lastname: Qiu
authors.forename: C
authors.initials: C
authors.lastname: Su
authors.forename: J P
authors.initials: JP
authors.lastname: Cao
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000909:Antibodies, Helminth / Q000097:blood*; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002681:China; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016015:Logistic Models; D008875:Middle Aged; D011223:Praziquantel / Q000627:therapeutic use; D012008:Recurrence; D012554:Schistosomiasis japonica / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000980:Antiplatyhelmintic Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E; D011223:Praziquantel