Preventive effects of Hange-shashin-to on irinotecan hydrochloride-caused diarrhea and its relevance to the colonic prostaglandin E2 and water absorption in the rat.
The possible preventive effect of Kampo medicine Hange-shashin-to (TJ-14) on chronic diarrheal symptoms induced by the administration of the anticancer agent irinotecan hydrochloride (CPT-11) was investigated in the rat. Repeated oral administrations of TJ-14 at 125 and 500 mg/kg significantly prevented the reduction in body weight and the onset of chronic diarrheal symptoms due to CPT-11 in a dose-dependent manner, even though it failed to show a definite effect on acute diarrheal symptoms. In addition, treatment with TJ-14 accelerated the healing of the intestinal tract injured by repeated dosing of CPT-11 and inhibited significantly the increase of colonic prostaglandin E2 (PGE2) which is closely related to the onset of diarrhea. TJ-14 also improved colonic water absorption impaired by repeated dosing of CPT-11 in rats. These results demonstrate that TJ-14 is an effective medicine for the prevention and/or treatment of CPT-11-induced chronic diarrheal symptoms.
Kase
Y
Y
Central Research Laboratories, Tsumura & Co., Inashiki-gun, Ibaraki, Japan.
Hayakawa
T
T
Aburada
M
M
Komatsu
Y
Y
Kamataki
T
T
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000633:toxicity; D003106:Colon / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control*; D015232:Dinoprostone / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D007408:Intestinal Absorption / Q000187:drug effects*; D000077146:Irinotecan; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D059004:Topoisomerase I Inhibitors; D014867:Water / Q000378:metabolism*; D015430:Weight Gain / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D059004:Topoisomerase I Inhibitors; C088236:hange-shashinto; D014867:Water; D000077146:Irinotecan; D015232:Dinoprostone; D002166:Camptothecin