title: Multi-start downhill simplex method for spatio-temporal source localization in magnetoencephalography.
abstract: A multi-start downhill simplex method is examined as a global minimization technique for fitting multidipole, spatio-temporal magnetoencephalography (MEG) data. This procedure has been performed on both simulated and empirical human visual data, known to exhibit complex field patterns due to multiple sources. Unlike some other non-linear fitting techniques the multi-start downhill simplex method does not require users to provide initial guesses for the dipole parameters, hence the fitting procedure is less time-consuming, more objective, and user-friendly. In addition, this method offers more than one adequate solution thus providing a range of uncertainty for the estimated parameters. The Multi-start downhill simplex method is used to fit the non-linear dipole spatial parameters, while the linear temporal parameters are fit using a separate linear fitting procedure. Singular value decomposition (SVD) is also used in order to improve the procedure for determining the adequate number of modeled dipoles.
authors.affiliation: Biophysics Group, Los Alamos National Laboratory, NM 87545, USA. mhuang@lawyer.lanl.gov
authors.forename: M
authors.initials: M
authors.lastname: Huang
authors.forename: C J
authors.initials: CJ
authors.lastname: Aine
authors.forename: S
authors.initials: S
authors.lastname: Supek
authors.forename: E
authors.initials: E
authors.lastname: Best
authors.forename: D
authors.initials: D
authors.lastname: Ranken
authors.forename: E R
authors.initials: ER
authors.lastname: Flynn
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008959:Models, Neurological; D017711:Nonlinear Dynamics; D010775:Photic Stimulation; D014793:Visual Cortex / Q000502:physiology*