Expression of human endogenous retrovirus ERV3 (HERV-R) mRNA in normal and neoplastic tissues.
We investigated the mRNA expression of the human endogenous retrovirus ERV3 (HERV-R) in several normal and corresponding tumor tissues. The env gene of ERV3 is expressed as mRNA in several tissues. Comparison of ERV3 mRNA expression by Northern analyses, revealed a non-systematic variation. Expression was shown to be particularly high in the adrenal gland and some cases of lung cancer. This tissue-tropism should be seen in relation to the high expression previously found in syncytiotrophoblasts in placenta and sebaceous glands of the skin, suggesting profound influences by steroid hormonal regulation.
Andersson
A C
AC
Department of Pathology, Uppsala University Hospital, S-751 85 Uppsala, Sweden.
Svensson
A C
AC
Rolny
C
C
Andersson
G
G
Larsson
E
E
D015152:Blotting, Northern; D020077:Endogenous Retroviruses / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D005814:Genes, Viral; D006801:Humans; D017403:In Situ Hybridization; D009369:Neoplasms / Q000235:genetics / Q000821:virology*; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000096:biosynthesis*; D012367:RNA, Viral / Q000096:biosynthesis*; D014018:Tissue Distribution; D014327:Trophoblasts
D012333:RNA, Messenger; D012367:RNA, Viral