title: Bone loss in young women with karyotypically normal spontaneous premature ovarian failure.
abstract: OBJECTIVE
  To evaluate the effects of karotypically normal spontaneous premature ovarian failure on femoral neck bone mineral density.
  
  
  METHODS
  Eighty-nine women with karyotypically normal spontaneous premature ovarian failure who desired fertility were evaluated at a tertiary care academic center and underwent hip and spinal bone density measurements by conventional dual-photon absorptiometry. Seventy-seven of the women (87%) had sought medical advice previously and had taken a variety of estrogen and progestin replacement regimens at least intermittently. The median (range) age was 32 (20-39) years, and the median (range) time since diagnosis was 1.5 (0.5-11) years. Findings were compared with a reference group of 218 regularly menstruating women of similar age.
  
  
  RESULTS
  Sixty of the 89 women with premature ovarian failure (67%, 95% confidence interval 57, 77) had a femoral neck bone mineral density more than 1 standard deviation (SD) below the mean of the reference group (P < .001, chi2 with Yates correction). Even in women in whom the bone mineral density measurement was made within just 1.5 years of the diagnosis, nearly one-half (47%) had a femoral neck bone mineral density more than 1 SD below the mean of the reference group (P < .01).
  
  
  CONCLUSIONS
  Two-thirds of young women with karyotypically normal spontaneous premature ovarian failure have a femoral neck bone mineral density more than 1 SD below the mean of a reference group. These young women need early education regarding strategies to maintain their bone mass and ongoing medical evaluation to maintain compliance with these strategies.
authors.affiliation: Section on Women's Health, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, and the Clinical Center Nursing Department, National Institutes of Health, Bethesda, Maryland 20892-1862, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Anasti
authors.forename: S N
authors.initials: SN
authors.lastname: Kalantaridou
authors.forename: L M
authors.initials: LM
authors.lastname: Kimzey
authors.forename: R A
authors.initials: RA
authors.lastname: Defensor
authors.forename: L M
authors.initials: LM
authors.lastname: Nelson
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D007621:Karyotyping; D016649:Primary Ovarian Insufficiency / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D011446:Prospective Studies; D011877:Radionuclide Imaging; D013131:Spine / Q000000981:diagnostic imaging / Q000502:physiology*