title: HLA class I and class II frequencies of a Hong Kong Chinese population based on bone marrow donor registry data.
abstract: HLA-A, and -B antigen, gene and haplotype frequencies have been calculated from 18,774 southern Chinese donors on a Hong Kong-based bone marrow donor registry. Two hundred and fifty donors were also tested for HLA-DRB1, -DQA1, and -DQB1 alleles using the PCR-SSP technique. Forty-one HLA-A, -B combinations showed statistically significant positive linkage disequilibrium at the 0.05 level after adjustment for the number of haplotypes theoretically possible and 43 showed significant negative disequilibrium. Thirty-nine different DRB1-DQA1-DQB1 haplotypes were identified of which 20 occurred 5 or more times. The most prevalent was DRB1*0901-DQA1*0301-DQB1*0303 (haplotype frequency = 0.1620). This is the first paper to report the distribution of DQA1*0104, DQA1*05011 and DQA1*05012/13 alleles in Chinese. These data are important for phylogenetic, comparative and medico-legal studies and are of particular value in estimating the likelihood of obtaining appropriately matched donors for Chinese patients awaiting bone marrow transplantation.
authors.affiliation: Department of Pathology, University of Hong Kong, Hong Kong.
authors.forename: Y W
authors.initials: YW
authors.lastname: Chang
authors.forename: B R
authors.initials: BR
authors.lastname: Hawkins
mesh_terms: D016026:Bone Marrow Transplantation / Q000706:statistics & numerical data*; D002681:China / Q000208:ethnology; D005787:Gene Frequency; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006723:Hong Kong; D006801:Humans; D012042:Registries; D014019:Tissue Donors
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II