Emodin-induced inhibition of growth and DNA damage in the Helicobacter pylori.
Studies were conducted to examine the dose effects of emodin on inhibition of growth versus DNA damage events in H. pylori from patients who had peptic ulcer disease. Inhibition of growth study from H. pylori demonstrated that emodin elicited dose-dependent growth inhibition in H. pylori cultures; that is, the greater the concentration of emodin, the greater the growth inhibition to H. pylori. However, S1 nuclease sensitivity analysis studies revealed that emodin induced dose-dependent DNA damage in H. pylori. Collectively, these results suggest that there was a possible relationship between the dose response to emodin and the inhibition of growth and DNA damage in H. pylori.
Wang
H H
HH
Department of Internal Medicine, China Medical College Hospital, Taichung, Taiwan, Republic of China.
Chung
J G
JG
D000328:Adult; D000368:Aged; D004269:DNA, Bacterial / Q000032:analysis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004642:Emodin / Q000494:pharmacology*; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015719:Single-Strand Specific DNA and RNA Endonucleases / Q000378:metabolism
D004269:DNA, Bacterial; D015719:Single-Strand Specific DNA and RNA Endonucleases; D004642:Emodin