[HHV-7 infection of CD4 gene-transduced cells].
It has been reported recently that CD4 is a major component of the receptor for human herpesvirus-7 (HHV-7), which has been newly identified as a T-lymphotropic virus. To investigate further the role of CD4 in HHV-7 infection, we examined the susceptibility to HHV-7 infection of various CD4-negative or weakly positive cell lines into which the cDNA for CD4 was transferred using an adenovirus vector. Out of 13 cell lines transduced with a CD4 gene, one T-lymphoid cell line, one monocytoid cell line, and two myeloid cell lines showed high susceptibility to HHV-7 infection. Taken together with previous studies, these data suggest strongly that CD4 is a major component of the binding receptor for HHV-7.
Yasukawa
M
M
First Department of Internal Medicine, Ehime University School of Medicine.
D000256:Adenoviridae; D015704:CD4 Antigens / Q000235:genetics*; D002460:Cell Line; D015967:Gene Expression Regulation, Viral; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006566:Herpesviridae Infections; D016199:Herpesvirus 7, Human; D006801:Humans; D008214:Lymphocytes / Q000821:virology*; D011991:Receptors, Virus / Q000235:genetics
D015704:CD4 Antigens; D011991:Receptors, Virus