[Effect of hydroxylated pyrimidine derivatives on activities of thiamine-dependent enzymes and some parameters of lipid metabolism in mice].
It has been found that hydroxylated pyrimidine derivatives actively participate in metabolic proceeds related to functioning of vitamin B1-dependent enzymes (transketolase, 2-oxo acid dehydrogenase). Hydroxypyrimidines also induce a significant increase in the levels of total lipids and cholesterol in the mice liver, not changing the phospholipid content.
Oparin
D A
DA
Gorenshteĭn
B I
BI
Karaedova
L M
LM
Naruta
E E
EE
Zabrodskaia
S V
SV
Rudiak
T V
TV
Akat'ev
V E
VE
Larin
F S
FS
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D006900:Hydroxylation; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism*; D050356:Lipid Metabolism; D051379:Mice; D010743:Phospholipids / Q000378:metabolism; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D014174:Transketolase / Q000378:metabolism*
D010743:Phospholipids; D011743:Pyrimidines; D011768:Pyruvate Dehydrogenase Complex; D002784:Cholesterol; D007655:Ketoglutarate Dehydrogenase Complex; D014174:Transketolase
Vliianie gidroksilirovannykh proizvodnykh pirimidina na aktivnost' tiaminzavisimykh fermentov i nekotorye pokazateli obmena lipidov u mysheĭ.