Etiology of AIDS-related Kaposi's sarcoma and lymphoma.
Kaposi's sarcoma (KS) and non-Hodgkin's lymphomas (NHL) are common consequences of HIV infection. These tumours appear to be precipitated by herpesviruses. Epstein-Barr virus (EBV) is implicated as a cause of up to 50% of systemic NHLs and up to 100% of central nervous system lymphomas in patients with AIDS. KS may be a consequence of the newly identified gamma-herpesvirus KSHV (KS-associated herpesvirus or HHV-8). This herpesvirus is found in all KS biopsies from different epidemiologic forms of this disease. KSHV is also implicated in the pathogenesis of a rare form of B cell lymphoma called body-cavity based lymphoma or primary effusion lymphoma (PEL).
Boshoff
C
C
Institute of Cancer Research, London, UK.
Whitby
D
D
Talbot
S
S
Weiss
R A
RA
D017088:AIDS-Related Opportunistic Infections / Q000209:etiology / Q000821:virology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D005260:Female; D015658:HIV Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D016867:Immunocompromised Host; D016483:Lymphoma, AIDS-Related / Q000209:etiology / Q000821:virology*; D008297:Male; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000821:virology*; D014412:Tumor Virus Infections / Q000209:etiology / Q000821:virology*