title: Age-associated alterations in sympathetic neural interactions with the immune system.
abstract: We have examined age-related alterations in sympathetic noradrenergic (NA) innervation in primary and secondary lymphoid organs from mouse and rat. As the thymus involuted with age, the density of NA innervation and norepinephrine (NE) concentration increased markedly. Total thymic NE was not altered significantly with age, suggesting that NA innervation is maintained as the thymus involutes. In the rat spleen, NA innervation and NE concentration were diminished with age. Enhanced antibody responses and in vitro proliferation to a T-dependent protein antigen were observed following selective destruction of NA nerve fibers with the neurotoxin 6-hydroxydopamine (6-OHDA), demonstrating that the diminished NA innervation in the aged spleen is capable of signaling the immune system. Plasticity of NA nerves in old rats was demonstrated following lesioning with 6-OHDA and in intact rats treated with L-deprenyl, a monoamine oxidase B inhibitor. These age-related alterations in NA innervation of lymphoid organs occur concurrently with age-associated changes in immune function. Understanding the functional relationship between these two physiological systems in aging will contribute to a greater understanding of sympathetic nervous system regulation of immune function.
authors.affiliation: Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, NY 14642, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Madden
authors.forename: S
authors.initials: S
authors.lastname: Rajan
authors.forename: D L
authors.initials: DL
authors.lastname: Bellinger
authors.forename: S Y
authors.initials: SY
authors.lastname: Felten
authors.forename: D L
authors.initials: DL
authors.lastname: Felten
mesh_terms: D000367:Age Factors; D000818:Animals; D006801:Humans; D008221:Lymphoid Tissue / Q000294:innervation; D051379:Mice; D009638:Norepinephrine; D051381:Rats; D013154:Spleen / Q000294:innervation; D013564:Sympathetic Nervous System / Q000276:immunology*; D013950:Thymus Gland / Q000294:innervation
chemical_list: D009638:Norepinephrine