title: A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13.
abstract: We performed a genome-wide linkage analysis search for a genetic locus responsible for kidney dysfunction in a large family. This inherited condition, characterized by proteinuria, progressive renal insufficiency, and focal segmental glomerulosclerosis, follows autosomal dominant inheritance. We show with a high degree of certainty (maximum 2-point lod score 12.28) that the gene responsible for this condition is located on chromosome 19q13.
authors.affiliation: Department of Medicine, Oklahoma State University College of Osteopathic Medicine, Tulsa, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Mathis
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Calabrese
authors.forename: M
authors.initials: M
authors.lastname: Haas
authors.forename: J G
authors.initials: JG
authors.lastname: Seidman
authors.forename: C E
authors.initials: CE
authors.lastname: Seidman
authors.forename: M R
authors.initials: MR
authors.lastname: Pollak
mesh_terms: D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005192:Family Health; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics* / Q000473:pathology; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree