Paternity in men with stage I testis tumors on surveillance.
OBJECTIVE
We report long-term paternity in men with stage I testis tumors who were managed initially by surveillance.


METHODS
One hundred five patients with clinical stage I nonseminomatous germ cell tumors of the testis were entered on a surveillance protocol and followed up for more than 10 years. Actual fertility potential was assessed by pregnancy.


RESULTS
Of the 105 patients, 41 (39%) have fathered children, which includes 36 of 78 (46%) patients while on active surveillance and five of 27 (19%) patients after treatment for relapse. Of 63 couples who attempted a pregnancy on surveillance or were presumed capable of impregnation (whether they tried or not), 41 (65%) were successful.


CONCLUSIONS
These results show that the majority of men with stage I testis tumor who are on surveillance after orchiectomy, have a suitable partner, and attempt impregnation achieve a successful pregnancy. Pregnancy rates appear to be less than reported in men who have a nerve-sparing retroperitoneal lymph node dissection (RPLND) because more patients on surveillance require treatment for relapse, which reduces their chances for pregnancy.
Herr
H W
HW
Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. herrh@mskcc.org
Bar-Chama
N
N
O'Sullivan
M
M
Sogani
P C
PC
D000293:Adolescent; D000328:Adult; D005260:Female; D005298:Fertility; D005500:Follow-Up Studies; D018237:Germinoma / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007248:Infertility, Male / Q000209:etiology; D008197:Lymph Node Excision / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011247:Pregnancy; D012008:Recurrence; D012187:Retroperitoneal Space; D013736:Testicular Neoplasms / Q000503:physiopathology* / Q000601:surgery