title: Incorporation of devitalised autografts in dogs.
abstract: Segments of the tibial diaphysis from 24 adult dogs were reimplanted after extracorporeal autoclaving or gamma-irradiation. Fixation was by interlocking intramedullary nailing, or plating. The dogs were killed after 36 weeks and the tibias examined. Bony union was seen in 46 of the 48 contact areas. Microangiography and Tc-perfusion scans demonstrated complete revascularisation of all the grafts. Biomechanical tests showed defective union with increased bending and decreased stiffness compared to normal controls. Fluorescent microscopy confirmed restitution of Haversian systems and slow replacement of the graft by lamellar bone containing viable osteocytes.
authors.affiliation: Orthopädische Klinik und Poliklinik, Eberhard-Karls-Universität Tübingen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Böhm
authors.forename: M A
authors.initials: MA
authors.lastname: Scherer
mesh_terms: D000792:Angiography; D000818:Animals; D001696:Biomechanical Phenomena; D016723:Bone Remodeling / Q000502:physiology*; D018483:Diaphyses / Q000637:transplantation; D004285:Dogs; D006253:Haversian System / Q000502:physiology; D008833:Microcirculation; D008856:Microscopy, Fluorescence; D011877:Radionuclide Imaging; D012092:Replantation / Q000379:methods*; D013242:Sterilization / Q000379:methods; D013669:Technetium Tc 99m Medronate; D013977:Tibia / Q000000981:diagnostic imaging / Q000637:transplantation*; D014182:Transplantation, Autologous / Q000379:methods
chemical_list: D013669:Technetium Tc 99m Medronate