title: Age and sex effects on brain morphology.
abstract: 1. Brain morphology can be assessed readily in vivo using magnetic resonance imaging (MRI). 2. In this study, the effects of age and sex on whole-brain morphology were examined using an operator-controlled computer-segmentation protocol. 3. Results indicated that age was associated with gray-matter volume reduction. 4. Brain-size differences between males and females were primarily attributable to white-matter volume. 5. This study confirms the importance of controlling for age and sex in brain-morphology studies.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Passe
authors.forename: P
authors.initials: P
authors.lastname: Rajagopalan
authors.forename: L A
authors.initials: LA
authors.lastname: Tupler
authors.forename: C E
authors.initials: CE
authors.lastname: Byrum
authors.forename: J R
authors.initials: JR
authors.lastname: MacFall
authors.forename: K R
authors.initials: KR
authors.lastname: Krishnan
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012727:Sex Characteristics