title: Myeloperoxidase activity in skin lesions. II. Influence of alcohol and some medicines.
abstract: The measurement of myeloperoxidase activity was used to quantify the acute granulocyte reaction. Ethyl alcohol given intraperitoneally in rats as doses of 3, 4 and 5 g per kg body weight resulted in a clear decrease of the myeloperoxidase activity at the edges of incision wounds. When one-half of the LD 50 dose of chlorpromazine was given intraperitoneally a remarkable decrease in the myeloperoxidase activity was observed. Moderate decreases were obtained with one-half of the LD 50 dose of acetyl salisylic acid and Na-pentobarbital and with high therapeutic doses of hydrocortisone and indomethacin.
authors.forename: K
authors.initials: K
authors.lastname: Laiho
mesh_terms: D000818:Animals; D015415:Biomarkers; D002746:Chlorpromazine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D005554:Forensic Medicine; D006098:Granulocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009195:Peroxidase / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000201:enzymology / Q000293:injuries* / Q000473:pathology; D014950:Wounds, Penetrating / Q000201:enzymology* / Q000473:pathology
chemical_list: D015415:Biomarkers; D000431:Ethanol; D009195:Peroxidase; D002746:Chlorpromazine