The antiatherogenic effect of nifedipine on intramural small coronary arterial lesions in cholesterol-fed rabbits.
The objective of this study was to examine the suppressive effect of nifedipine on intramural coronary arterial lesions in cholesterol-fed rabbits. Each rabbit in Groups A (n=6) and B (n=5) was fed a 0.3% cholesterol diet and was orally administered nifedipine (40 mg/day) or placebo. Each rabbit in Groups C (n=5) and D (n=6) was fed a 0.5% cholesterol diet and was orally administered nifedipine (40 mg/day) or placebo. The serum concentrations of total cholesterol (TC) were determined at 1-week intervals to calculate the integrated values. The lesion induction ratio was defined as the ratio of intramural coronary arteries 50-150 microm in diameter with arterial lipoidosis to the total number of arteries of the same diameter. There were no significant differences between the nifedipine-treated and placebo groups in either the integrated TC or lesion induction ratio in either the 0.3% and 0.5% cholesterol-fed rabbits. This study demonstrates that nifedipine does not suppress atherogenesis in the intramural small coronary arteries of cholesterol-fed rabbits.
Kato
H
H
Department of Internal Medicine, Saga Medical School, Japan.
Okada
R
R
Enoki
M
M
Oogushi
K
K
Emura
S
S
Takashima
T
T
Ohmori
K
K
D000284:Administration, Oral; D000818:Animals; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000473:pathology; D003327:Coronary Disease / Q000188:drug therapy* / Q000473:pathology; D003331:Coronary Vessels / Q000187:drug effects* / Q000473:pathology; D004036:Diet, Atherogenic; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000473:pathology; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008833:Microcirculation / Q000473:pathology; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D011817:Rabbits; D011897:Random Allocation; D017211:Treatment Failure
D002121:Calcium Channel Blockers; D002791:Cholesterol, Dietary; D000960:Hypolipidemic Agents; D010919:Placebos; D002784:Cholesterol; D009543:Nifedipine