Inhibitory effects of fatty acid monoesters of 2-O-beta-D-glucosylglycerol on Epstein-Barr virus activation.
In a screening for cancer chemopreventing agents several glycosylglycerols were found to be active. In order to optimize the anti-tumor activity of this class of compounds, a series of 1-O-acyl-2-O-beta-D-glucopyranosyl-sn-glycerols differing in the acyl chain length, which varied from C4 to C18, were examined for their in vitro anti-tumor promoting effects on Epstein-Barr virus early antigen (EBV-BA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among the compounds tested, the monohexanoyl derivative was the most active and, noteworthy, the most potent compound of the glycosylglycerol series hitherto known.
Colombo
D
D
Dipartimento di Chimica e Biochimica Medica, Università di Milano, Italy.
Scala
A
A
Taino
I M
IM
Toma
L
L
Ronchetti
F
F
Tokuda
H
H
Nishino
H
H
Nagatsu
A
A
Sakakibara
J
J
D000956:Antigens, Viral / Q000032:analysis; D000970:Antineoplastic Agents / Q000737:chemistry*; D001681:Biological Assay; D005227:Fatty Acids / Q000737:chemistry; D006017:Glycolipids / Q000737:chemistry / Q000494:pharmacology*; D004854:Herpesvirus 4, Human; D006801:Humans; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000187:drug effects
D000956:Antigens, Viral; D000970:Antineoplastic Agents; D005227:Fatty Acids; D006017:Glycolipids; D013755:Tetradecanoylphorbol Acetate