Phenytoin toxicity in an older patient with slow metabolism and atypical presentation.
Phenytoin toxicity occurred in an older man who received a dosage of 300 mg/day. The patient developed high serum phenytoin concentrations from this common adult dosage, with symptoms of functional decline and altered mental status. These behaviors were perceived as sun-downing and were treated with haloperidol. A long hospitalization was required.
Pitner
J K
JK
Division of Geriatrics and Extended Care, Ralph H. Johnson V.A. Medical Center, and Medical University of South Carolina, Charleston 29401-5799, USA.
Long
L D
LD
Meyer
R P
RP
Pennypacker
L C
LC
D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000009:adverse effects* / Q000378:metabolism*; D003704:Dementia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000378:metabolism*; D012640:Seizures / Q000188:drug therapy / Q000378:metabolism
D000927:Anticonvulsants; D010672:Phenytoin