[Systematic calciphylaxis in chronic renal failure: fulminant course after kidney transplantation].
Description of a 27 years old patient with chronic renal failure due to diabetes, which requires dialysis, and tertiary hyperparathyroidism, who developed fulminant systemic calciphylaxis after successful renal transplantation. Characteristic of this syndrome, there occurred soft tissue calcification, mediacalcinosis of the small and medium-sized arteries and ischemic skin necrosis. The pathogenesis is not completely clear, but challenging agents like corticosteroids or immunosuppressants, in a sensitized organism (at hypercalcemia or elevated parathormon) could lead to calcium deposits. These are showing a particular affinity for elastic tissue. Lungs, stomach, kidneys, cutis, heart and vascular system are most frequently involved. Treatment is primarily supportive; an early parathyroidectomy seems to have the best prognosis.
Barbur
M A
MA
Institut für Allgemeine Pathologie und Pathologische Anatomie, Technischen Universität München.
Kurjak
M
M
Becker
K
K
D000328:Adult; D001158:Arteries / Q000473:pathology; D002114:Calcinosis / Q000209:etiology / Q000473:pathology; D002115:Calciphylaxis / Q000209:etiology* / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000601:surgery; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000473:pathology*; D008297:Male; D009336:Necrosis; D011183:Postoperative Complications; D012867:Skin / Q000473:pathology
Systemische Kalziphylaxie bei chronischer Niereninsuffizienz: fulminanter Verlauf nach Nierentransplantation.