title: Contact lens associated bacterial keratitis: past, present, and future.
abstract: OBJECTIVE
  This paper reviews the medical history of the pathogenesis of contact lens related bacterial keratitis and its relationship to the development of successive generations of soft contact lenses.
  
  
  METHODS
  The Methods section presents a literature review and the author's personal experience.
  
  
  RESULTS
  Bacterial corneal infections have been a significant complication limiting the overall success of soft contact lenses for visual correction. Experience with different types of lenses has pointed to specific causes for the frequency of infection. However, there has been a general understanding that the health of the patient's epithelium, the patient's lens care practices, and the hypoxic effects of overnight wear each significantly contribute to the development of corneal infection.
  
  
  CONCLUSIONS
  A complete understanding of the pathogenesis of contact lens associated bacterial infection would allow the development of strategies to prevent infectious complications of lens wear. Progress appears to have been made with a trend toward fewer and less severe infections. As the possibility of a reasonably priced daily wear disposable lens with better oxygen transmissibility and surface modifications to limit deposits and bacterial adherence evolves, safer lenses will continue to be developed.
authors.affiliation: University of Florida College of Medicine, Gainesville, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Stern
mesh_terms: D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects / Q000639:trends*; D003315:Cornea / Q000382:microbiology; D004209:Disposable Equipment; D015818:Eye Infections, Bacterial / Q000209:etiology / Q000517:prevention & control*; D005544:Forecasting; D006801:Humans; D007634:Keratitis / Q000209:etiology / Q000517:prevention & control*; D012307:Risk Factors