[The selective effect of monoclonal antibodies to the nerve growth protein A3G7 on the central mechanisms of different types of defensive behavior in adult rats].
The behavioral effects were studied of monoclonal antibodies (MA) against A3G7 protein, which is known to be associated with the processes of nervous cell differentiation. Elaboration, storage, and retention of acoustic startle (ASR) habituation and freezing behavior were tested in adult rats. The MA applied in a dose of 50 ng on cerebellar vermis selectively impaired only the ASR long-term habituation storage whereas its dose of 5 mcg impaired both long-term habituation storage and fear-conditioned freezing. Application of 10 mcg of MA disrupted the elaboration and storage of the ASR short- and long-term habituation as well as fear-conditioned freezing. The results are considered as experimental verification of systemogenesis theory and hypothesis about a common molecular basis of learning and development.
Sherstnev
V V
VV
Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
Pletnikov
M V
MV
Storozheva
Z I
ZI
Proshin
A T
AT
D000161:Acoustic Stimulation; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D002531:Cerebellum / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology; D008297:Male; D009414:Nerve Growth Factors / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D000911:Antibodies, Monoclonal; D009414:Nerve Growth Factors
Izbiratel'noe vliianie monoklonal'nykh antitel k neĭrorostovomu belku A3G7 na tsentral'nye mekhanizmy razlichnykh vidov oboronitel'nogo povedeniia u vzroslykh krys.