title: Preparation and characterization of sustained-release microspheres of chlorpromazine.
abstract: Sustained release microspheres of chlorpromazine were prepared from Eudragit RS 100 by an emulsion-solvent evaporation method using a six-baffled vessel. The morphology of microspheres was characterized by scanning electron microscopy (SEM). In the presence of aluminium tristearate (5%), microspheres were spherical in shape and uniform. The release of chlorpromazine from microspheres was pH-independent. With increasing amount of aluminium tristearate and increasing ratio of Eudragit RS 100/drug from 1:1 to 9:1, the particle size of chlorpromazine microspheres was reduced and the release rate decreased. The microspheres prepared with the polymer/drug ratio of 9:1 produced a 12-h sustained release pattern.
authors.affiliation: College of Pharmacy, Seoul National University, South Korea.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Gao
authors.forename: K H
authors.initials: KH
authors.lastname: Oh
authors.forename: C K
authors.initials: CK
authors.lastname: Kim
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D002746:Chlorpromazine / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D006863:Hydrogen-Ion Concentration; D008863:Microspheres
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D002746:Chlorpromazine