title: Growth failure as the first expression of malnutrition in children with human immunodeficiency virus infection.
abstract: BACKGROUND
  To define the onset, pattern, and earliest manifestations of malnutrition related to HIV infection.
  
  
  METHODS
  A retrospective cross-sectional analysis of changes in weight and growth in a group of 54 children with perinatally acquired HIV infection was conducted. Eight children had asymptomatic HIV infection, 26 had symptomatic infection, and 20 had symptomatic infection and were referred for nutritional support.
  
  
  RESULTS
  We found an early decline in the rate of linear growth with a relative preservation of the weight-for-age. Weight-for-height measurements were preserved until there was advanced HIV-related disease.
  
  
  CONCLUSIONS
  This pattern can result in a false impression of adequate nutrition and emphasizes the importance of longitudinal growth data of the child with HIV infection. Evidence of linear growth failure before clinical wasting is apparent is an absolute indication for aggressive nutritional support.
authors.affiliation: Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: V B
authors.initials: VB
authors.lastname: Peters
authors.forename: J R
authors.initials: JR
authors.lastname: Rosh
authors.forename: L
authors.initials: L
authors.lastname: Mugrditchian
authors.forename: A H
authors.initials: AH
authors.lastname: Birnbaum
authors.forename: K J
authors.initials: KJ
authors.lastname: Benkov
authors.forename: D S
authors.initials: DS
authors.lastname: Hodes
authors.forename: N S
authors.initials: NS
authors.lastname: LeLeiko
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D006130:Growth Disorders / Q000209:etiology*; D019247:HIV Wasting Syndrome / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D012189:Retrospective Studies; D018709:Statistics, Nonparametric