[The central mechanisms of the stimulating influence of intervalic hypoxic conditioning on the endocrine function of the pancreas in rats].
In the investigation of Wistar rats the morpho-functional state of the neurons of the dorsal motor nucleus of n. vagus (DVC), locus coeruleus (LC) and peptidergic neurons of medical parvocellular subnuclei of paraventricular nucleus of hypothalamus (PVHmp) in the conditions of intermittent hypoxic training (IHT) (6 hours a day on the altitude 6000 m for 21 day) was studied. Immunocytochemical method was used to determine the functional state of peptidergic neurons of PVMmp and of the median eminence of hypothalamus, which are synthesizing neurotensin, cholecystokinin, bombesin, leu- and met-enkephalins, calcitonin-gene-related peptide and vasointestinal peptide. It was established that IHT leads to the activation of peptidergic neurons of PVHmp, neurons of DVC and to the lesser restrain of LC. It is demonstrated that these structures may take part in realisation of IHT's stimulating effect on the state of pancreatic beta-cells. In consists of insulin-stimulating and insulocyteprotective effects, that can be realised by the hypothalamic and neuroconducting ways of regulation of endocrine pancreas, with direct participation of hypothalamic neuropeptides.
Abramov
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D000818:Animals; D001273:Atmosphere Exposure Chambers; D000860:Hypoxia / Q000503:physiopathology*; D007515:Islets of Langerhans / Q000502:physiology*; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology*
Tsentral'ni mekhanizmy stymuliuiuchoho vplyvu interval'nykh hipoksychnykh trenuvan' na endokrynnu funktsiiu pidshlunkovoĭ zalozy shchuriv.