title: Echocardiographic detection of the extent of coronary artery disease in the elderly using dobutamine and adenosine infusion.
abstract: BACKGROUND
  The high prevalence of asymptomatic multivessel disease in the elderly and the fact that most of them can not carry out an exercise stress testing renders the application of other stress modalities necessary. The aim of this study is to compare the diagnostic value of dobutamine and adenosine stress echocardiography and their accuracy in determining the extent of coronary artery disease in elderly people.
  
  
  METHODS
  Dobutamine and adenosine stress echocardiography were performed in 128 consecutive patients > or = 70 years-of-age with known or suspected coronary artery disease. All patients underwent coronary angiography within 2 weeks of the stress tests.
  
  
  RESULTS
  The presence of any echocardiographic abnormality on dobutamine (odds ratio 30.8) and adenosine (odds ratio 18.1) test, the need for cessation of dobutamine test and the ST depression during dobutamine infusion, were independent predictors of significant coronary artery disease. Both tests proved more sensitive for detecting multivessel disease (89% for dobutamine, 74% for adenosine test), than one-vessel disease (74 and 39%, respectively). This difference was statistically significant only for the adenosine echocardiography test (P = 0.008). In patients with localized resting wall motion abnormalities, the accuracy of dobutamine test to predict a remotely diseased vessel (70%), was statistically superior to the accuracy of adenosine test (57%, P = 0.008). Patients with multivessel disease showed delayed resolution of test-induced wall motion abnormalities, during the recovery period after both tests, compared with those who suffered from one-vessel disease.
  
  
  CONCLUSIONS
  Dobutamine echocardiography was more sensitive and accurate than adenosine echocardiography in detecting and determining the extent and the severity of coronary artery disease in the elderly. A positive adenosine echocardiography result reflected the presence of advanced coronary artery disease. The two tests, combined with clinical data, could classify the elderly into low- and high-risk subgroups for ischemic heart disease.
authors.affiliation: First Department of Cardiology, Evangelismos' Hospital, Athens, Greece.
authors.forename: L P
authors.initials: LP
authors.lastname: Anthopoulos
authors.forename: M S
authors.initials: MS
authors.lastname: Bonou
authors.forename: E P
authors.initials: EP
authors.lastname: Sioras
authors.forename: A I
authors.initials: AI
authors.lastname: Kranidis
authors.forename: F G
authors.initials: FG
authors.lastname: Kardaras
authors.forename: I P
authors.initials: IP
authors.lastname: Antonellis
mesh_terms: D000241:Adenosine; D000368:Aged; D000789:Angina, Unstable / Q000503:physiopathology; D002316:Cardiotonic Agents; D002637:Chest Pain / Q000209:etiology; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D004280:Dobutamine; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine; D000241:Adenosine