Which is the threshold glycose value for further investigation in pregnancy?
The aim of this study was to investigate the lower threshold glycose value in a 50 gr-1 hour screening test for further testing in diagnosing gestational diabetes mellitus (GDM). Our study consisted of 602 pregnant women between 24-28 weeks of gestation, who received a 50 gr glycose load followed by glycose determination one hour later. After screening 273 out of 602 women showed test serum glycose values > 125 mg/dl. All 273 women received a 100 gr 3-hour glycose tolerance test (GTT). Thirty out of 273 women were found to have carbohydrate intolerance. The overall incidence of GDM was 4.98%. When the threshold glycose value was > or = 130 mg/dl the incidence of GDM was 17.8%, but lowering the threshold to 126 mg/dl a further 1.3% of the women showed carbohydrate intolerance. In the above threshold value the sensitivity was 100% but the specificity was only 54%. However, we recommend 126 mg/dl threshold for GTT since this threshold allows for the diagnosis of all women with carbohydrate intolerance during pregnancy.
Vitoratos
N
N
2nd Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Salamalekis
E
E
Bettas
P
P
Kalabokis
D
D
Chrisikopoulos
A
A
D000328:Adult; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D015994:Incidence; D008403:Mass Screening; D011247:Pregnancy; D012680:Sensitivity and Specificity
D001786:Blood Glucose