[Measures for the prevention of infections in patients with bone marrow transplantations].
One of the most frequent complications in patients undergoing bone marrow transplantation (BMT) is represented by severe infectious episodes, neutropenia being the most important factor. Among preventive measures, those represented by careful hygenic and environmental procedures are of pivotal importance. In this study, we retrospectively analyzed the infectious episodes in 295 patients subjected to BMT who have been treated with the same caring protocol. In 21.8% of patients an infectious event was recorded during the post-BMT period; in patients subjected to BMT from an unrelated donor the incidence of positive haemocultures was as high as 33.3%. Sixty-five per cent of isolated agents in haemocultures were Gram-positive, 33% Gram-negative and only 2% fungi. In 35% of patients with positive haemocultures, the same infectious agent had previously been isolated in a skin sample. Overall, the incidence of documented infections was lower than in other studies, suggesting that careful protocols of personal and environmental hygene may be very important for the prevention of infectious episodes in BMT patients.
Rasero
L
L
Unità di Trapianto di Midollo Osseo, Divisione di Ematologia, Ospedale di Careggi, Firenze.
Errico
A
A
Bertelli
A
A
D001424:Bacterial Infections / Q000209:etiology* / Q000517:prevention & control*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D006920:Hygiene; D017053:Infection Control / Q000379:methods*
Misure per la prevenzione delle complicanze infettive in pazienti sottoposti a trapianto di midollo osseo. Esperienza del Centro Trapianti di Firenze.