Trisomy 1 in a canine acute leukemia indicating the pathogenetic importance of polysomy 1 in leukemias of the dog.
We report on a canine acute myeloid leukemia showing a trisomy 1 and a t(X;8) as clonal cytogenetic abnormalities. Comparing these results with similar cases of canine leukemias reported in the literature, one realizes that trisomy 1 is a recurrent cytogenetic finding in canine acute leukemia. Trisomy 1 may be a specific anomaly associated with either etiology or progression of this disease. As with comparable human neoplasms, cytogenetic investigations could be of diagnostic and prognostic significance for canine hematopoietic diseases. Moreover, as trisomies are recurrent cytogenetic findings in human leukemias, as well, comparative gene mapping in future studies may help to focus the etiologic basis of the disease to particular chromosomal segments instead of whole chromosomes.
Reimann
N
N
Center for Human Genetics and Genetic Counseling, University of Bremen, Germany.
Bartnitzke
S
S
Bullerdiek
J
J
Mischke
R
R
Nolte
I
I
D000208:Acute Disease; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D007938:Leukemia / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D014178:Translocation, Genetic; D014314:Trisomy