HLA-Cw*1602: a new susceptibility marker of Behçet's disease in southern Spain.
Genotyping of the HLA-C locus by PCR-SSP in Behçet's disease patients from southern Spain reveals a statistically significant association with Cw*1602 (OR 20.15, corrected p < 0.05). This is an uncommon allele absent from the healthy control group, which seems to confer higher relative risk than B51 in this study (OR 1.85). Stratified frequencies do not show statistically significant differences but suggest that the Cw*1602-B51 haplotype could be the main HLA marker of Behçet's disease in the analyzed population.
Sanz
L
L
Servicio de Inmunología, Clínica Puerta de Hierro, Madrid, Spain.
González-Escribano
F
F
de Pablo
R
R
Núñez-Roldán
A
A
Kreisler
M
M
Vilches
C
C
D000483:Alleles; D000951:Antigens, Neoplasm; D001528:Behcet Syndrome / Q000235:genetics* / Q000276:immunology; D015415:Biomarkers; D004198:Disease Susceptibility / Q000276:immunology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000235:genetics*; D013030:Spain
D000951:Antigens, Neoplasm; D015415:Biomarkers; C072011:MAGEA1 protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins