title: Effects of prenatal morphine and cocaine exposure on spinal sexual reflexes in male and female rats.
abstract: Previous studies demonstrated that in utero exposure to morphine or cocaine differentially alters adult sexual behaviors, which are dependent on circulating gonadal hormones in male and female rats. In the present study, the effects of in utero morphine and cocaine exposure on the urethrogenital reflex were examined. The urethrogenital reflex is thought to be a hormone-independent spinal sexual reflex in both males and females. This reflex is tonically inhibited by supraspinal neurons but can be consistently evoked by urethral stimulation in the spinally transected animals. Prenatal morphine or cocaine exposure did not remove the supraspinal inhibition of the urethrogenital reflex in spinally intact male or female rats. In spinally transected animals, the urethrogenital reflex was qualitatively similar in all groups. However, morphine-exposed males required a stronger stimulus to elicit the urethrogenital reflex but once elicited, the frequency of the urethrogenital reflex was significantly higher compared to either controls or cocaine-exposed males. In contrast, in female rats, neither prenatal morphine nor cocaine exposure had any effect on the urethrogenital reflex. Thus, the urethrogenital reflex appears to be differentially affected by prenatal exposure to morphine in males and females.
authors.affiliation: Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: I
authors.initials: I
authors.lastname: Vathy
authors.forename: L
authors.initials: L
authors.lastname: Marson
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D005260:Female; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
chemical_list: D009294:Narcotics; D009020:Morphine; D003042:Cocaine