[An immunohistochemical study of tenascin expression in cerebellar medulloblastomas].
The paper presents the results of immunohistochemical study of tenascin expression in 62 specimens of cerebellar medulloblastomas. All tumors can be classified as belonging to one of the 3 types of immunoreactivity: (1) tenascin-negative medulloblastomas, (2) tumors with extracellular and (3) intracellular expression of tenascin. Immunoreactivity was demonstrated in 61% of specimens. It perfectly matches the incidence of metastases. Medulloblastomas with intracellular tenascin expression demonstrated higher proliferative potential and are capable of expressing other oncoproteins (i.e. p 53, bcl-2). The data obtained in the study brought us to the conclusion that in patients with positive tenascin expression the prognosis is worse.
Korshunov
A G
AG
Golanov
A V
AV
Sycheva
R V
RV
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000378:metabolism* / Q000473:pathology; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008527:Medulloblastoma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D015513:Oncogene Proteins / Q000378:metabolism; D019063:Tenascin / Q000378:metabolism*
D015513:Oncogene Proteins; D019063:Tenascin
Immunogistokhimicheskoe izuchenie ékspressii tenastsina v medulloblastomakh mozzhechka.