Gastric perforation with Candida tropicalis invasion in a previously healthy girl.
Fungal cells were observed infiltrating the submucosal margins of an acutely perforated gastric ulceration in an apparently immunocompetent 3-year-old girl. Perforation had occurred 24 h after hospital admission because of pain and vomiting. Colonies of Candida tropicalis were grown from peritoneal fluid and blood cultures. After surgical repair and a 30-day treatment with amphotericin B at a daily dose of 1 mg kg-1 body weight, the child was discharged in good health. No further infections have occurred in the 3 years since treatment.
Faure-Fontenla
M A
MA
Laboratorio de Immunología y Reumatología, Hospital Infantil de México Federico Gómez, México City, México.
Bracho-Blanchet
E
E
Yañez-Molina
C
C
Barragan-Tame
L
L
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications* / Q000628:therapy; D002675:Child, Preschool; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D007121:Immunocompetence; D008297:Male; D010146:Pain; D012422:Rupture, Spontaneous / Q000150:complications / Q000382:microbiology / Q000628:therapy; D013275:Stomach Rupture / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D013276:Stomach Ulcer / Q000150:complications* / Q000382:microbiology / Q000628:therapy; D014839:Vomiting
D000935:Antifungal Agents; D000666:Amphotericin B