Telomerase: a promising marker of biological immortality of germ, stem, and cancer cells. A review.
This review will describe the current state of knowledge of telomerase as it relates to human malignancies, focusing primarily on published measurements of this enzymes activity in benign and malignant neoplasms and their normal tissue counterparts. Key questions concerning the potential clinical utility of assaying for telomerase activity will be addressed and the implications of recent findings discussed.
Meeker
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James Buchanan Brady Urological Institute Research Laboratories, Johns Hopkins Hospital, Baltimore, Maryland 21287-2101, USA.
Coffey
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D015415:Biomarkers; D005260:Female; D005854:Germ Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D019098:Telomerase / Q000032:analysis / Q000378:metabolism*; D016615:Telomere / Q000502:physiology*
D015415:Biomarkers; D019098:Telomerase