Studies on antimicrobial effect of the antihistaminic phenothiazine trimeprazine tartrate.
The antibacterial and bactericidal activities of the antihistamine trimeprazine were studied against 243 strains of bacteria which included both Gram positive and Gram negative types. The susceptibility of these bacterial strains to trimeprazine was assessed by determining their minimum inhibitory concentration (MIC) which was found to be between 10 and 100 micrograms/ml. Nineteen strains of Staphylococcus spp. and Salmonella spp. were trimeprazine. Most of the strains belonging to Bacillus spp. and Salmonella spp. were inhibited by less than 100 micrograms/ml. Trimeprazine could also inhibit strains of Shigella spp. Vibrio cholerae and V. parahaemolyticus at 10-100 micrograms/ml. Strains of klebsiella, proteus, pseudomonas and citrobacter were moderately sensitive to trimeprazine. In in vivo studies it was seen that when trimeprazine was used at a concentration of 0.75 and 0.4 micrograms/gm body weight of the mouse both levels offered significant protection to Swiss mice challenged with 50LD50 of virulent strain of S. typhimurium 74. Statistical analysis of the data was found to be significant, p < 0.001 according to chi 2 test.
Dastidar
S G
SG
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Jairaj
J
J
Mookerjee
M
M
Chakrabarty
A N
AN
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D051379:Mice; D014291:Trimeprazine / Q000031:analogs & derivatives*
D000900:Anti-Bacterial Agents; D006634:Histamine H1 Antagonists; D014291:Trimeprazine