Individual T cells hold unexpected clues to the nature of anergy and memory.
The primary interest of our laboratory is understanding how the signals that a T cell receives influence its behavior during an immune response. Recently, we have focused our attention on the examination of T cell responses at an individual cell level. This article outlines our approach, presents our initial findings, and discusses the implications of these findings relative to our current models of T cell activation.
Wells
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AD
Department of Microbiology/Immunology, University of Pennsylvania, Philadelphia, USA.
Turka
L A
LA
D000818:Animals; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*