[The role of mononuclear phagocytes in the immunopathogenesis of HIV infection].
The functional state of HIV-infected monocytes in 153 persons aged 20-59 years was studied. It was characterized by an increase in the production of monokines (TNF-alpha, IL1 beta) at stages IIB-IIIA, pronounced activation of the synthesis of DNA at stages IIB-IIC of the disease due to mass intracellular production of viral proteins. At the same stages an increase in the activity of lactate dehydrogenase and a decrease in the activity of succinate dehydrogenase were noted, which was indicative of an increase in the intensity of the process of anaerobic oxygenation at early of infection with the simultaneous decrease of the intensity of the tricarbon acid cycle and the subsequent suppression of the immunoregulating properties of monocytes.
Zmushko
E I
EI
Military Medical Academy, St. Petersburg, Russia.
Dmitriev
V I
VI
Malkov
A N
AN
Mikhal'tsov
A N
AN
Bolekhan
V N
VN
Mikhaĭlov
N V
NV
D000293:Adolescent; D000328:Adult; D004247:DNA / Q000096:biosynthesis; D015658:HIV Infections / Q000097:blood / Q000145:classification / Q000209:etiology* / Q000276:immunology; D015497:HIV-1; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism; D008875:Middle Aged; D010084:Oxidation-Reduction; D010586:Phagocytes / Q000276:immunology* / Q000378:metabolism; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D004247:DNA
Rol' mononuklearnykh fagotsitov v immunopatogeneze VICh-infektsii.