title: Familial acute myeloid leukaemia: four male members of a single family over three consecutive generations exhibiting anticipation.
abstract: A kindred with familial acute myeloid leukaemia (AML) is described displaying the concept of anticipation which refers to increased disease severity and/or earlier age at onset with succeeding generations. The affected individual in the first generation was the father (aged 34 years at diagnosis) of two affected members of a single sibship (aged 24 and 25 years). The fourth patient is the son (aged 4 years) of one of these brothers in the second generation. The AML was of different subtypes and a karyotypic abnormality (del[6q]) was detected in one of three patients. The first-generation patient died during chemotherapy; the remaining three patients are in complete remission after chemotherapy and autologous bone marrow transplantation.
authors.affiliation: Department of Academic Haematology, Royal Marsden Hospital, Sutton, Surrey.
authors.forename: C
authors.initials: C
authors.lastname: De Lord
authors.forename: R
authors.initials: R
authors.lastname: Powles
authors.forename: J
authors.initials: J
authors.lastname: Mehta
authors.forename: K
authors.initials: K
authors.lastname: Wilson
authors.forename: J
authors.initials: J
authors.lastname: Treleaven
authors.forename: S
authors.initials: S
authors.lastname: Meller
authors.forename: D
authors.initials: D
authors.lastname: Catovsky
mesh_terms: D000208:Acute Disease; D000328:Adult; D017668:Age of Onset; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D017809:Fatal Outcome; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000628:therapy; D008297:Male; D010375:Pedigree; D013921:Thrombocytopenia / Q000235:genetics / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents