Treatment of fibrinolytic alveolitis with rifamycin B diethylamide associated with gelfoam: a histological study.
The most common complication in the healing of extraction wounds is fibrinolytic alveolitis, which may also be termed "dry socket". Reduction in the incidence of this condition after the application of topical antibiotics and the use of systemic antibiotics has been reported. A histological study of disturbed alveolar socket healing in rats was carried out to analyze the influence of application of rifamycin B diethylamide (Rifocin M) associated or not with Gelfoam. Sixty-four male rats (Rattus norvegicus albinus, Wistar), weighing 120-150 g, were divided into 4 groups of 16 animals each. In the second group of rats which received implants of Gelfoam, there was an intense resorption of bone walls in the initial stage. The rats that received implants of Gelfoam saturated with Rifocin M (fourth group) showed better results than the second group. The third group (only irrigation with rifamycin) showed better bone formation in the alveolar socket compared to the first, second and fourth groups. Thus, these results showed that rifamycin irrigation is useful in the control of alveolar infections.
de Carvalho
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Departamento de Diagnostico e Cirurgia Oral, Faculdade de Odontologia, Universidade Estadual Paulista Julio de Mesquita Filho, Araçatuba, SP, Brasil.
Mariano
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RC
Okamoto
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T
D000287:Administration, Topical; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004368:Dry Socket / Q000188:drug therapy* / Q000473:pathology*; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012294:Rifamycins / Q000627:therapeutic use*; D013997:Time Factors; D014081:Tooth Extraction; D014945:Wound Healing / Q000187:drug effects
D012294:Rifamycins; C009186:rifamide