[An experimental model of benzodiazepine intoxication].
It has been demonstrated in rat experiments that intraperitoneal injection of 100 mg/kg phenazepam immobilizes the animals for one hour, causes long-term diminution of the muscular tonus and disturbed coordination of movements, tachycardia, hypotension, hyperthermia, depression of orientation and exploration motor activity, and disturbance of conditioned reflexes of active and passive avoidance. It is concluded that the changes in the above-indicated parameters of autonomic and behavioral status of rats under the effect of a 100 mg/kg dose of phenazepam are clearly expressed for a long period of time, are specific to the effect of benzodiazepines and may therefore serve as a model of severe BD intoxication for evaluating the efficacy of their antidotes. This has been confirmed in experiments with the well-known BD antagonist phlumazelin.
Georgianova
E K
EK
Institute of Toxicology, Russian Federation Ministry of Public Health, St. Petersburg, Russia.
Lychakov
A V
AV
Malov
A M
AM
Nikolaev
A I
AI
Petrov
A N
AN
Savateeva
T N
TN
Tomilin
N V
NV
Shevchuk
M K
MK
Shestova
G V
GV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000506:poisoning*; D000931:Antidotes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000506:poisoning*; D004195:Disease Models, Animal; D005442:Flumazenil / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D011041:Poisoning / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D051381:Rats
D014151:Anti-Anxiety Agents; D000931:Antidotes; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D005442:Flumazenil
Eksperimental'naia model' otravleniia benzodiazepinami.