Plasma lactic acid and pyruvic acid levels in migraine and tension-type headache.
We examined the lactic and pyruvic acid levels in the plasma of 14 patients with migraine, 17 patients with tension-type headache, and 12 normal controls. The lactic and pyruvic acid levels in the plasma of the migraine patients were significantly higher than those of the normal controls (9.6 +/- 5.0 mg/dL and 0.51 +/- 0.30 mg/dL versus 3.3 +/- 1.9 mg/dL and 0.26 +/- 0.20 mg/dL, respectively). There were no significant differences in the levels between the patients with tension-type headache and normal controls. Our results suggest that migraine patients may have functional abnormalities in mitochondrial energy metabolism.
Okada
H
H
Division of Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.
Araga
S
S
Takeshima
T
T
Nakashima
K
K
D000328:Adult; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology; D008928:Mitochondria / Q000378:metabolism* / Q000502:physiology; D019289:Pyruvic Acid / Q000097:blood*; D018781:Tension-Type Headache / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology
D019344:Lactic Acid; D019289:Pyruvic Acid