Leptin injected into the fourth ventricle inhibits gastric emptying.
The effect of leptin on gastric emptying of glucose was studied in freely moving rats bearing intragastric fistulas. Leptin (0.39 microg and 3.9 microg) injected into the fourth ventricle inhibited gastric emptying significantly, whereas s.c. administration of leptin (10 microg/kg) had no effect. Leptin receptor immunoreactivity, revealed by an antiserum that recognizes all leptin receptor isoforms, was demonstrated in choline acetyltransferase (ChAT)-containing neurones of the dorsal motor nucleus of the vagus nerve (DMX). The data indicate that leptin acts centrally to suppress gastric emptying possibly via leptin receptors located on cholinergic DMX neurones.
Smedh
U
U
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Håkansson
M L
ML
Meister
B
B
Uvnäs-Moberg
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D005746:Gastric Emptying / Q000187:drug effects*; D007150:Immunohistochemistry; D007276:Injections, Intraventricular; D020738:Leptin; D008297:Male; D008969:Molecular Sequence Data; D011506:Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology
D020738:Leptin; D011506:Proteins; D011994:Recombinant Proteins