Antiatherosclerotic effect of Lipotab Forte in cholesterol-fed rabbits.
The effect of Lipotab Forte, a new polypharmaceutical herbal formulation developed on the principles of the Unani system of medicine, was investigated on the progression of atherosclerosis in cholesterol fed rabbits. Retardation of the progression of atherosclerosis was observed in animals treated with Lipotah Forte. The results were related to changes in the cholesterol content of aorta from the same animal. Blood cholesterol and triglyceride levels were greatly elevated in all rabbits on cholesterol feeding, but were significantly decreased by Lipotab Forte treatment. Lipotab Forte treatment also lowered aorta Thiobarbituric acid reactive substance (TBARS) levels from 79.72 (+/-5.70) to 24.9 (+/-2.04) nmol/g of wet tissue and reduced hepatic cholesterol significantly in hypercholesterolemic rabbits.
Raj kumar
S
S
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, Hamdard University, Hamdard Nagar, New Delhi, India.
Pillai
K K
KK
Balani
D K
DK
Hussain
S Z
SZ
D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000473:pathology / Q000628:therapy*; D002448:Cell Adhesion; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D005260:Female; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D011817:Rabbits; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D002784:Cholesterol