title: Autoimmune ovarian disease: mechanism of disease induction and prevention.
abstract: Investigation of the versatile models for autoimmunity of the ovary and other selected organs has contributed to our understanding of the following aspects of autoimmunity: the mechanism of T cell molecular mimicry; T-->B epitope spreading, as a basis for autoantibody diversification, and as a link between organ-specific and systemic autoimmunity; the localization of genetic loci potentially influencing multiple autoimmune diseases; and the elucidation of regulatory T cells as a component of physiological self tolerance.
authors.affiliation: Department of Pathology, University of Virginia, Charlottesville 22908, USA. kst7k@Virginia.edu
authors.forename: K S
authors.initials: KS
authors.lastname: Tung
authors.forename: Y H
authors.initials: YH
authors.lastname: Lou
authors.forename: K M
authors.initials: KM
authors.lastname: Garza
authors.forename: C
authors.initials: C
authors.lastname: Teuscher
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D001327:Autoimmune Diseases / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D005260:Female; D006801:Humans; D008211:Lymphocyte Cooperation; D051379:Mice; D018716:Molecular Mimicry; D010049:Ovarian Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology