Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria.
Quinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg) were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were similar to those reported previously for the 2 compounds given individually to a similar group of patients. Although postural hypotension was common (6 cases before treatment and 7 after) and the electrocardiogram QTc interval was prolonged by a mean of 12% (SD = 8) following drug treatment, there was no evidence of a clinically significant cardiovascular pharmacodynamic interaction between these 2 structurally related antimalarial compounds.
Supanaranond
W
W
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Suputtamongkol
Y
Y
Davis
T M
TM
Pukrittayakamee
S
S
Teja-Isavadharm
P
P
Webster
H K
HK
White
N J
NJ
D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000188:drug therapy*; D015767:Mefloquine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D011803:Quinine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*
D000962:Antimalarials; D011803:Quinine; D015767:Mefloquine