title: Doppler-derived left ventricular rate of pressure rise and inotropic requirements during mitral valve surgery.
abstract: BACKGROUND
  The estimation of left ventricular (LV) contractility is difficult in the presence of significant mitral regurgitation (MR). Prediction of LV performance after MR repair is even more problematic. The intraoperative Doppler-derived LV rate of pressure rise (LV delta P/delta t) analyzed before cardiopulmonary bypass (CPB) was presumed to be a useful predictive parameter for LV performance. Therefore, its relation to perioperative inotropic requirements (PIR) necessary for separation from CPB after surgical MR repair was investigated.
  
  
  METHODS
  Twenty-eight patients scheduled for surgical MR repair fulfilled the selection criteria. Pre-CPB LV delta P/delta t, pre-CPB echocardiographic LV fractional area change (LV FAC), and pre-CPB thermodilution-derived cardiac index (CI) were recorded. After MR repair, separation from CPB was performed with regard to standardized guidelines. PIR during the first 60 minutes following separation were recorded.
  
  
  RESULTS
  Pre-CPB LV delta P/delta t could be assessed in 22 patients. Pre-CPB LV delta P/delta t was 882 +/- 450 mmHg/sec, pre-CPB LV FAC was 49% +/- 9%, and pre-CPB CI was 2.0 +/- 0.2 L/kg/min. Pre-CPB LV delta P/delta t was significantly correlated with pre-CPB LV FAC (r = 0.56), and with pre-CPB CI (r = 0.72). Inotropic support was necessary in 16 patients (73%), and was best predicted by the pre-CPB LV delta P/delta t, by means of logistic regression (p = 0.026).
  
  
  CONCLUSIONS
  Doppler-derived LV delta P/delta t was assessable in most patients with severe chronic MR, and was the best intraoperative predictive parameter of post-CPB inotropic requirements after surgical MR repair.
authors.affiliation: Department of Anesthesiology, University Clinics UCL of Mont-Godinne, Yvoir, Belgium.
authors.forename: S M
authors.initials: SM
authors.lastname: Broka
authors.forename: A R
authors.initials: AR
authors.lastname: Ducart
authors.forename: J
authors.initials: J
authors.lastname: Jamart
authors.forename: E L
authors.initials: EL
authors.lastname: Collard
authors.forename: X R
authors.initials: XR
authors.lastname: Fournet
authors.forename: S
authors.initials: S
authors.lastname: Chevalier
authors.forename: B A
authors.initials: BA
authors.lastname: Marchandise
authors.forename: K L
authors.initials: KL
authors.lastname: Joucken
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000503:physiopathology / Q000601:surgery*; D009200:Myocardial Contraction; D016277:Ventricular Function, Left