Schizophrenic patients before and after HIV infection: a case-control study.
Thirteen HIV positive schizophrenic patients (Group 1), age ranging from 23 to 60 years, diagnosed as schizophrenics (DSM IV), were studied during a four week hospitalization period, due to an acute exacerbation phase. The patients were treated with haloperidol (3-15 mg/die p.o.) and diazepam (2-25 mg/die p.o.). Clinical picture and side-effects were assessed by BPRS, HRS-A, HRS-D, and DOTES, at admission and after 2, 3, 4 weeks of hospitalization period (Time 5, 7, 8, 9). Clinical evaluations were compared to a previous hospitalization period, before seroconversion (Time 0, 2, 3, 4), and to a control group (Group 2) of HIV negative schizophrenic patients (11 pb) followed as well during 2 periods of hospitalization. Our data seem to emphasize that the HIV infection could induce organic alterations in the CNS which might cause psychopathological consequences: significantly more severe depressive symptomatology and a reduction of tolerability to neuroleptics in the seroconverted patients' group.
Mauri
M C
MC
Department of Clinical Psychiatry, University of Milan, IRCCS, Ospedale Maggiore di Milano, Italy.
Fabiano
L
L
Bravin
S
S
Ricci
C
C
Invernizzi
G
G
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006679:HIV Seropositivity / Q000523:psychology*; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D006220:Haloperidol; D003975:Diazepam