Variation of the total amount of fluoride in blood of young women during the menstrual cycle.
We have previously reported the distribution and the forms of fluorides in the blood of men. This study is concerned with the distribution of fluorides in the blood of young women and sex-related differences in the fluoride metabolism related to the calcium metabolism keeping the postmenopausal osteoporosis in mind. The present study shows that women, aged 18 to 20 years, retain more fluorides in blood compared with men and that the nonionic fluoride level in blood varies during a menstrual cycle, whereas the ionic fluoride level is constant. Since fluoride has strong affinity for calcium, behavior of fluoride may reflect that of calcium balance during the menstrual cycle. However, fluoride which binds to calcium is believed to be ionic. Therefore, there must be a transformation between ionic fluoride and nonionic fluoride in order to keep the homeostasis.
Kimura
T
T
Department of Chemistry, Shiga University of Medical Science, Japan.
Hayakawa
F
F
Yamamoto
G
G
Yoshitake
K
K
Ando
T
T
D000328:Adult; D002118:Calcium / Q000097:blood / Q000378:metabolism; D005260:Female; D005459:Fluorides / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood* / Q000378:metabolism
D005459:Fluorides; D002118:Calcium