title: Basal activity of the hypothalamic-pituitary-adrenal axis in patients with the chronic fatigue syndrome (neurasthenia).
abstract: BACKGROUND
  Impairments in both basal activity and activation of the hypothalamic-pituitary-adrenal axis (HPA) have been reported in chronic fatigue syndrome (CFS; neurasthenia). We sought to replicate these findings and examined basal activity of the HPA in a carefully selected sample of patients with CFS.
  
  
  METHODS
  Basal activity of the HPA was assessed using salivary and urinary cortisol collection over a 24-hour period in 22 (12 male; 10 female) patients meeting criteria for CFS and appropriate controls.
  
  
  RESULTS
  Salivary and urinary cortisol measures did not differ between CFS patients and controls.
  
  
  CONCLUSIONS
  Basal activity of the HPA was not reduced in CFS patients. Reasons for the failure to replicate previous findings are discussed.
authors.affiliation: University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom.
authors.forename: A H
authors.initials: AH
authors.lastname: Young
authors.forename: M
authors.initials: M
authors.lastname: Sharpe
authors.forename: A
authors.initials: A
authors.lastname: Clements
authors.forename: B
authors.initials: B
authors.lastname: Dowling
authors.forename: K E
authors.initials: KE
authors.lastname: Hawton
authors.forename: P J
authors.initials: PJ
authors.lastname: Cowen
mesh_terms: D000328:Adult; D015673:Fatigue Syndrome, Chronic / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism / Q000652:urine; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D010912:Pituitary-Adrenal Function Tests; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011863:Radioimmunoassay; D012463:Saliva / Q000378:metabolism
chemical_list: D006854:Hydrocortisone