The Philadelphia chromosome as a secondary change in leukemia: three case reports and an overview of the literature.
Three cases of acute nonlymphocytic leukemia with a Philadelphia chromosome (Ph) as a secondary abnormality are reported. The Ph was late-appearing in one patient and appeared as an additional anomaly in the other two patients. Fluorescence in situ hybridization studies of the first patient identified the presence of a minor BCR/ABL rearrangement. The findings of these cases support the conclusion that the Ph plays a role not only in leukemogenesis, but also in disease progression. An overview of the literature dealing with similar cases is also presented.
Chen
Z
Z
Genzyme Genetics, Scottsdale, Arizona, USA.
Morgan
R
R
Notohamiprodjo
M
M
Meloni-Ehrig
A
A
Schuster
R T
RT
Bennett
J S
JS
Cohen
J D
JD
Stone
J F
JF
Sandberg
A A
AA
D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology; D008297:Male; D010677:Philadelphia Chromosome