Extracellular levels of neuropeptide Y are markedly increased in the dorsal hippocampus of freely moving rats during kainic acid-induced seizures.
In this microdialysis study we measured the extracellular neuropeptide Y (NPY) levels in the dorsal hippocampus of conscious rats. During potassium-induced depolarisations, a 93% increase in extracellular levels of NPY was observed. NPY has been demonstrated to reduce kainic acid-induced convulsions in rats, but it is unknown whether NPY neurotransmission is affected by seizures. During seizures induced by kainic acid we observed a 104% increase in levels of NPY, suggesting that convulsions are associated with a dramatically increased NPYergic neurotransmission.
Husum
H
H
Department of Neurobiology, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Copenhagen-Valby, Denmark.
Mikkelsen
J D
JD
Mørk
A
A
D000818:Animals; D006624:Hippocampus / Q000378:metabolism*; D007608:Kainic Acid; D008297:Male; D017551:Microdialysis; D009068:Movement / Q000502:physiology*; D009478:Neuropeptide Y / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
D009478:Neuropeptide Y; D007608:Kainic Acid