title: Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients.
abstract: Linoleic acid is the most abundant fatty acid in human low density lipoproteins (LDL). Oxidation of LDL transforms linoleic acid to hydroperoxyderivatives. These are converted to 9-hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE). 9-HODE is much more abundant in oxidized LDL than other lipid peroxidation products and therefore an indicator of lipid peroxidation (LPO). In this study the 9-HODE content in the LDL of 19 obviously healthy volunteers and 17 atherosclerotic patients was investigated. The level of 9-HODE obtained from LDL of young atherosclerotic patients (aged 36-47 years) was increased by a factor of 20 when compared with samples from healthy volunteers of the same age group. The content of 9-HODE in the LDL of atherosclerotic patients aged between 69 and 94 years increased 30-100 fold when compared with young healthy individuals, but when compared with 'healthy' individuals of the same age group it was only 2-3 fold increased. Obviously, as individuals grow older LDL becomes more and more oxidized. Consequently, assuming that LDL oxidation is a precondition for atherosclerosis--older individuals will suffer from atherosclerosis, even if no easy detectable visible signs of this disease are recognizable. According to 9-HODE determination, the onset of the disease starts slowly in most individuals at around 50 years of age.
authors.affiliation: Lehrstuhl für Organische Chemie I, Universität Bayreuth, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Jira
authors.forename: G
authors.initials: G
authors.lastname: Spiteller
authors.forename: W
authors.initials: W
authors.lastname: Carson
authors.forename: A
authors.initials: A
authors.lastname: Schramm
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008041:Linoleic Acids / Q000378:metabolism*; D044243:Linoleic Acids, Conjugated; D008054:Lipid Peroxides / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000032:analysis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography
chemical_list: D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; C024347:9-hydroxy-10,12-octadecadienoic acid; C024348:13-hydroxy-9,11-octadecadienoic acid