Further antineoplastic terpenylquinones and terpenylhydroquinones.
Influences of the quinone/hydroquinone fragment and other structural features are considered in relation with the antineoplastic activity and selectivity of terpenylquinones/hydroquinones. Several compounds have shown IC50 values under the microM level.
Miguel del Corral
J M
JM
Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
Gordaliza
M
M
Castro
M A
MA
Mahiques
M M
MM
San Feliciano
A
A
García-Grávalos
M D
MD
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011809:Quinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D006873:Hydroquinones; D011809:Quinones; D013729:Terpenes