title: Association between HLA-A1 allele and schizophrenia gene(s) in patients refractory to conventional neuroleptics but responsive to clozapine medication.
abstract: We report an association between HLA-A1 allele and a subgroup of schizophrenic patients refractory to conventional neuroleptic treatment but responsive to clozapine. The frequency of HLA-A1 was 58% among the schizophrenic patients not responding to conventional treatment but responsive to clozapine but only 10.5% among the patients responding to conventional neuroleptics. The HLA-A1 occurs in 20% of the random Finnish population. Our results indicate that HLA-A1 defines a subgroup of schizophrenic patients with a selective response to neuroleptics.
authors.affiliation: Department of Pathology, Haartman Institute, University of Helsinki, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Lahdelma
authors.forename: A
authors.initials: A
authors.lastname: Ahokas
authors.forename: L C
authors.initials: LC
authors.lastname: Andersson
authors.forename: M
authors.initials: M
authors.lastname: Huttunen
authors.forename: S
authors.initials: S
authors.lastname: Sarna
authors.forename: S
authors.initials: S
authors.lastname: Koskimies
mesh_terms: D000328:Adult; D000483:Alleles; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use; D005260:Female; D005387:Finland; D005787:Gene Frequency; D008040:Genetic Linkage; D015788:HLA-A1 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*
chemical_list: D014150:Antipsychotic Agents; D015788:HLA-A1 Antigen; D003024:Clozapine