[Infants of diabetic mothers (IDM). I -- Macrosomia and growth factors].
OBJECTIVE
The objective of this study was to determine the incidence of macrosomia in infants of diabetic mothers (IDM) and to analyze its possible correlation with insulin, C-peptide, growth hormone (GH) and IGF-I levels in umbilical cord blood.


METHODS
A prospective study of 58 IDM and 58 control newborns (33 males and 25 females in both groups) was carried out.


RESULTS
The incidence of macrosomia was 25.8% in the IDM group and 61.5% in the IIDDM group (infant of insulin-dependent diabetic mother) compared to 5% in the control group. There was a positive correlation between maternal Hgb Alc levels in the third trimester of gestation and insulin and C-peptide levels with newborn weight in the IDM group (especially in the IIDDM group). IGF-I levels were positively correlated with newborn weight in both control and IDM groups. There was no correlation between GH and IGF-I levels in any group.
Martín Carballo
G
G
Servicio de Endocrinología, Hospital Infantil La Paz, Madrid.
Fernández Cano
G
G
Grande Aragón
C
C
Méndez Alavedra
J
J
Hawkins Carranza
F
F
Gracia Bouthelier
R
R
D002096:C-Peptide / Q000097:blood; D002657:Child Development; D003924:Diabetes Mellitus, Type 2; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005320:Fetal Macrosomia / Q000097:blood* / Q000453:epidemiology; D006454:Hemoglobins / Q000032:analysis; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D008297:Male; D011446:Prospective Studies
D002096:C-Peptide; D006454:Hemoglobins; D007328:Insulin; D019382:Human Growth Hormone
El recién nacido hijo de madre diabética (RNHMD). I--Macrosomia y factores de crecimiento.