Derangement of warfarin anticoagulation by miconazole oral gel.
The potentiation of the anticoagulant effects of warfarin by miconazole, when used in oral gel form, is described in three patients. The associated morbidity is examined, emphasising the importance of considering this potentially serious interaction when prescribing antifungal agents to patients on oral anticoagulants.
Pemberton
M N
MN
Clinical Academic Group of Oral Medicine and Dental Diagnostic Science, University Dental Hospital of Manchester.
Sloan
P
P
Ariyaratnam
S
S
Thakker
N S
NS
Thornhill
M H
MH
D000284:Administration, Oral; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D002180:Candidiasis, Oral / Q000188:drug therapy; D003288:Contusions / Q000139:chemically induced; D004347:Drug Interactions; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008551:Melena / Q000139:chemically induced; D008825:Miconazole / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced; D011693:Purpura / Q000139:chemically induced; D013282:Stomatitis, Denture / Q000188:drug therapy / Q000382:microbiology; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D000925:Anticoagulants; D000935:Antifungal Agents; D005782:Gels; D014859:Warfarin; D008825:Miconazole