title: Psychiatric symptoms and syndromes among adolescent children of parents with lithium-responsive or lithium-nonresponsive bipolar disorder.
abstract: OBJECTIVE
  The purpose of this pilot study was to describe the initial course of psychiatric illness in the adolescent children of parents with bipolar disorder who were divided into two groups on the basis of their response to long-term lithium monotherapy.
  
  
  METHODS
  Proband parents met Research Diagnostic Criteria for bipolar illness and predetermined criteria for a clear response or nonresponse to lithium prophylaxis. All adolescent offspring were interviewed by a blinded interviewer using the Schedule for Affective Disorders and Schizophrenia for School-Age Children, and final diagnosis was made by blinded consensus.
  
  
  RESULTS
  Psychiatrically ill children of lithium-responsive parents tended to have affective disorders that remitted and followed a recurrent course. Psychiatrically ill children of lithium-nonresponsive parents, however, manifested a broad range of psychopathology, had high rates of comorbid illnesses, and experienced nonremitting affective illnesses.
  
  
  CONCLUSIONS
  These results suggest that family history and course of illness are important factors to consider in the diagnosis and pharmacological treatment of affective disorders.
authors.affiliation: Affective Disorders Service, Royal Ottawa Hospital, Ont., Canada.
authors.forename: A
authors.initials: A
authors.lastname: Duffy
authors.forename: M
authors.initials: M
authors.lastname: Alda
authors.forename: S
authors.initials: S
authors.lastname: Kutcher
authors.forename: C
authors.initials: C
authors.lastname: Fusee
authors.forename: P
authors.initials: P
authors.lastname: Grof
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy / Q000523:psychology; D002648:Child; D016241:Child of Impaired Parents; D015897:Comorbidity; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000453:epidemiology; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D016896:Treatment Outcome
chemical_list: D008094:Lithium