title: [Chronic HIV- and chronic HBV infection with hematuria and proteinuria].
abstract: METHODS
  A medical examination, undertaken in an apparently healthy 30-year-old man because of his occupational exposure to chemicals, revealed haematuria and proteinuria. Physical examination was unremarkable except for oral hair-leukoplakia and swelling of the cervical, supraclavicular, axillary and inguinal lymph nodes.
  
  
  METHODS
  Examination of the urine demonstrated selective glomerular proteins (1.5 g/24 h) and dysmorphic erythrocytes. SGOT and SGPT activities were raised (73 and 129 IU/l, respectively). Active hepatitis B virus (HBV) and human immunodeficiency virus (HIV-1) infections were demonstrated virologically. The CD4+ count in blood was reduced to 200 cells/microliter. Renal biopsy showed an IgA nephropathy.
  
  
  METHODS
  Antiretroviral treatment with zidovudine and lamivudine were started. SGOT and SGPT activities and HIV load fell steadily, while CD4+ cell count rose markedly. Renal functions have remained stable during the past 6 months.
  
  
  CONCLUSIONS
  Signs of glomerular damage are not unusual in systemic diseases, tumors or infections (Hepatitis B and HIV in this case) and they may be the first manifestations of the underlying disease.
authors.affiliation: Medizinische Kliniken, Klinikum Grosshadern. Kai.vonAppen@lrz.uni-muenchen.de
authors.forename: K
authors.initials: K
authors.lastname: von Appen
authors.forename: U
authors.initials: U
authors.lastname: Beuers
authors.forename: A
authors.initials: A
authors.lastname: Mühlhöfer
authors.forename: M
authors.initials: M
authors.lastname: Weiss
authors.forename: G H
authors.initials: GH
authors.lastname: Thoenes
authors.forename: W
authors.initials: W
authors.lastname: Samtleben
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002908:Chronic Disease; D004784:Environmental Monitoring; D004906:Erythrocyte Count; D015497:HIV-1 / Q000302:isolation & purification*; D015386:Hazardous Substances / Q000009:adverse effects; D006417:Hematuria / Q000209:etiology*; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects; D011507:Proteinuria / Q000209:etiology*; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D015386:Hazardous Substances; D019259:Lamivudine; D015215:Zidovudine
vernacular_title: Chronische HIV- und chronische HBV-Infektion mit Erythrozyturie und Proteinurie.