FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
FADD (also known as Mort-1) is a signal transducer downstream of cell death receptor CD95 (also called Fas). CD95, tumor necrosis factor receptor type 1 (TNFR-1), and death receptor 3 (DR3) did not induce apoptosis in FADD-deficient embryonic fibroblasts, whereas DR4, oncogenes E1A and c-myc, and chemotherapeutic agent adriamycin did. Mice with a deletion in the FADD gene did not survive beyond day 11.5 of embryogenesis; these mice showed signs of cardiac failure and abdominal hemorrhage. Chimeric embryos showing a high contribution of FADD null mutant cells to the heart reproduce the phenotype of FADD-deficient mutants. Thus, not only death receptors, but also receptors that couple to developmental programs, may use FADD for signaling.
Yeh
W C
WC
Amgen Institute, University of Toronto, Toronto, Ontario, Canada.
de la Pompa
J L
JL
McCurrach
M E
ME
Shu
H B
HB
Elia
A J
AJ
Shahinian
A
A
Ng
M
M
Wakeham
A
A
Khoo
W
W
Mitchell
K
K
El-Deiry
W S
WS
Lowe
S W
SW
Goeddel
D V
DV
Mak
T W
TW
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017209:Apoptosis; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004317:Doxorubicin / Q000494:pharmacology; D005314:Embryonic and Fetal Development; D004730:Endothelium, Vascular / Q000196:embryology; D053200:Fas-Associated Death Domain Protein; D005260:Female; D015870:Gene Expression; D018390:Gene Targeting; D006321:Heart / Q000196:embryology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009154:Mutation; D009857:Oncogenes; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D019014:fas Receptor / Q000235:genetics / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C505534:Fadd protein, mouse; D053200:Fas-Associated Death Domain Protein; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; D004317:Doxorubicin