title: [Prevention of hemorrhage and dental treatment of patients with congenital or acquired coagulopathies].
abstract: The physiopathology of the hemorrhagic blood coagulation disorders caused by genetic or aquired problems is described. Among the former the most frequent ones include the hemophilia of type A-B and the von Willebrand disease, among the latter the use of oral anticoagulant constitutes the most frequent cause. If the are not subjected to an adequate haemostatic prophylaxis, both patients with hemophilia and von Willebrand disease present a serious haemorrhagic risk as a consequence of dental practice. As far as the use of anticoagulants is concerned, a periodical monitoring of the time of prothrombin (PT) is needed to find the right dosage (TP between 20%-30% or INR--international normalized radio between 2 and 3.5). Values over this range cause an increase of the hemorrhagic risk, while lower values involve an increased risk of thrombotic events. According to the authors the patients with the hemorrhagic diathesis show a precise handicap, caused both by his illness and by environmental elements, such as the fear of doctors for the haemorrhagic complications consequent to a therapeutical operation, fear that often leads to neglect important medical measures, in particular dental measures. The specialized dental surgeon has to mantain a strict cooperation with the hematologist in order to arrange an appropriate procedure of the prophylaxis. As far as the hemostatic prophylaxis is concerned, the use of the dermopressin (DDAVP), in patients with hemophilia A and von Willebrand disease, guarantees the realisation of dental practice without hemorrhagic risk. On the contrary, the use of the tranhexanic acid on patients in an anticoagulant oral treatment gives hemostatic security and makes it possible to carry on the therapy and the out-patient treatment.
authors.affiliation: Servizio di Odontoiatria, Ospedale di Sandrigo, Vicenza.
authors.forename: R
authors.initials: R
authors.lastname: Vangelisti
authors.forename: O
authors.initials: O
authors.lastname: Pagnacco
authors.forename: G
authors.initials: G
authors.lastname: Ristagno
authors.forename: M
authors.initials: M
authors.lastname: Ruggeri
authors.forename: A
authors.initials: A
authors.lastname: Tosetto
authors.forename: G
authors.initials: G
authors.lastname: Castaman
authors.forename: F
authors.initials: F
authors.lastname: Rodeghiero
mesh_terms: D001778:Blood Coagulation Disorders; D003729:Dental Care; D006467:Hemophilia A / Q000503:physiopathology; D006801:Humans; D006472:Oral Hemorrhage / Q000517:prevention & control*; D013515:Surgery, Oral; D014842:von Willebrand Diseases / Q000503:physiopathology
vernacular_title: Profilassi antiemorragica e trattamento odontoiatrico dei pazienti con coagulopatie congenite ed acquisite.