Role of spinal premotoneurones in mediating corticospinal input to forearm motoneurones in man.
1. Evidence was sought to support the suggestion that corticospinal input can be relayed to motoneurones (MNs) via a population of interneurones (premotoneurones) in the cervical cord, and that this pathway operates in parallel with the direct monosynaptic pathway. 2. Single motor units were recorded in forearm muscles and post-stimulus time histograms (PSTHs) of their firing pattern were constructed during voluntary activation. Weak transcranial magnetic stimulation of the contralateral motor cortex was used to produce a small facilitation in the PSTH. We then examined how the size of this peak was affected by low threshold electrical stimulation of either the homonymous muscle nerve or the musculo-cutaneous nerve at various interstimulus intervals (ISIs). 3. Homonymous nerve stimulation had the following characteristics: (a) the cortical peak was facilitated when stimuli were timed so that both inputs arrived simultaneously at the MN; (b) the amount of facilitation was only slightly greater than the sum of the effects of each stimulus given alone; and (c) facilitation affected even the earliest bins of the cortically evoked peak. These three features are consistent with a monosynaptic input onto the MN from both sources. 4. Stimulation of the musculo-cutaneous nerve (which has no monosynaptic connections with forearm MNs) had no effect at similar timings. It (a) produced facilitation only at longer intervals corresponding to an extra central delay of 4-6 ms; (b) always gave a significantly larger facilitation than expected from the algebraic sum of the effects of each stimulus given alone; and (c) never affected the earliest bins of the cortical peak. These features are compatible with interaction of peripheral and cortical inputs at a population of premotoneurones. 5. These results confirm the suggestion that premotoneurones mediate part of the cortical command to MNs innervating forearm muscles. 6. Excitation is followed by an inhibition which may almost completely suppress the cortical peak. It is suggested that cortical and musculo-cutaneous volleys also converge onto inhibitory interneurones projecting to the premotoneuronal pool.
Pauvert
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Laboratoire de Neurophysiologie Clinique, Reeducation, Hopital de la Salpetriere, 47 boulevard de l'Hopital, F-75651 Paris cedex 13, France.
Pierrot-Deseilligny
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Rothwell
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D000328:Adult; D013181:Cortical Spreading Depression / Q000502:physiology; D004558:Electric Stimulation; D005542:Forearm / Q000294:innervation*; D007839:Functional Laterality; D006801:Humans; D008280:Magnetics; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology*; D009068:Movement / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation*; D012867:Skin / Q000294:innervation; D013116:Spinal Cord / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology