title: Management of acute leg ischaemia in the elderly.
abstract: BACKGROUND
  Peripheral thrombolysis is advocated by some as the best initial treatment for acute leg ischaemia; but this may not be true for elderly patients. This study reviewed the management of acute leg ischaemia in patients aged over 75 years.
  
  
  METHODS
  Over a 5-year interval, 91 events of acute leg ischaemia in 84 patients were managed in a single district general hospital according to a local protocol. There were 60 women and 24 men of median age 81 (range 75-100) years. Fifteen patients were too elderly and infirm for active treatment and received anticoagulation alone. Some 76 events (84 per cent) occurred in patients suitable for active therapy: 33 were managed by initial surgery and 43 by peripheral thrombolysis with tissue plasminogen activator.
  
  
  RESULTS
  Overall outcome after 30 days was limb salvage in 48 (53 per cent), amputation in five (5 per cent) and death in 38 (42 per cent). In actively treated patients the corresponding values were 43 (57 per cent), four (5 per cent) and 29 (38 per cent). Initial successful revascularization was more likely following surgery (29 of 33 versus 25 of 43 events with thrombolysis, P < 0.01), but the 30-day outcome was similar in the actively treated groups owing to subsequent morbidity and mortality.
  
  
  CONCLUSIONS
  A group of patients (mostly women) with emboli could be identified, using clinical criteria, who had a high chance of successful revascularization following embolectomy. Late outcome remained poor due to associated co-morbid conditions. Thrombolysis is associated with substantial risk in the elderly, and with high complication rates.
authors.affiliation: Department of Surgery, Gloucestershire Royal Hospital, UK.
authors.forename: B D
authors.initials: BD
authors.lastname: Braithwaite
authors.forename: B
authors.initials: B
authors.lastname: Davies
authors.forename: P A
authors.initials: PA
authors.lastname: Birch
authors.forename: B P
authors.initials: BP
authors.lastname: Heather
authors.forename: J J
authors.initials: JJ
authors.lastname: Earnshaw
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D002423:Cause of Death; D017128:Embolectomy / Q000379:methods; D005260:Female; D006801:Humans; D007511:Ischemia / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants