title: Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness.
abstract: alpha-Tectorin is one of the major noncollagenous components of the mammalian tectorial membrane in the inner ear. We have mapped the gene encoding alpha-tectorin to mouse chromosome 9 and human chromosome 11 in a known region of conserved synteny. Human YAC clones containing alpha-tectorin have been identified, demonstrating physical linkage to the anonymous marker D11S925. This places alpha-tectorin within the genetic interval that contains both the human nonsyndromic autosomal dominant deafness DFNA12 and the proximal limit of a subset of deletions within Jacobsen syndrome. Thus both DFNA12 and the hearing loss in some cases of Jacobsen syndrome may be due to haploinsufficiency for TECTA.
authors.affiliation: MRC Institute of Hearing Research, University of Nottingham, United Kingdom. davidh@ihr.mrc.ac.uk
authors.forename: D C
authors.initials: DC
authors.lastname: Hughes
authors.forename: P K
authors.initials: PK
authors.lastname: Legan
authors.forename: K P
authors.initials: KP
authors.lastname: Steel
authors.forename: G P
authors.initials: GP
authors.lastname: Richardson
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D003638:Deafness / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D058851:GPI-Linked Proteins; D005799:Genes, Dominant; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D016326:Extracellular Matrix Proteins; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; C491350:TECTA protein, human; C105350:Tecta protein, mouse