title: Is seborrhea a sign of autonomic impairment in Parkinson's disease?
abstract: An increase of sebum excretion rate (SER) is frequently observed in patients suffering from Parkinson's disease (PD). Some authors attribute it to the hyperactivity of the parasympathetic system, while others consider the possible action of androgens or of MSH-hormone. The aim of our study was to verify and quantify SER in 70 parkinsonian patients and compare it with SER in 60 normal subjects. We found higher values of SER in male subjects, both in normal and in parkinsonian patients. The highest rate of excretion was observed in parkinsonian males, in agreement with the possible main role of androgens or testosterone in sebum excretion, while the phenomenon did not appear to be related to abnormalities of the autonomic nervous system. The association of PD and sex hormones might therefore be crucial for the developing of seborrhea.
authors.affiliation: Parkinson's Disease and Movement Disorders' Centre, Department of Neurology, IRCCS C. Mondino, University of Pavia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Martignoni
authors.forename: L
authors.initials: L
authors.lastname: Godi
authors.forename: C
authors.initials: C
authors.lastname: Pacchetti
authors.forename: E
authors.initials: E
authors.lastname: Berardesca
authors.forename: G P
authors.initials: GP
authors.lastname: Vignoli
authors.forename: G
authors.initials: G
authors.lastname: Albani
authors.forename: F
authors.initials: F
authors.lastname: Mancini
authors.forename: G
authors.initials: G
authors.lastname: Nappi
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D001341:Autonomic Nervous System / Q000503:physiopathology*; D012628:Dermatitis, Seborrheic / Q000209:etiology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D008055:Lipids / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D012727:Sex Characteristics; D012867:Skin / Q000737:chemistry
chemical_list: D000978:Antiparkinson Agents; D008055:Lipids; D007980:Levodopa