title: Pulpal tissue reaction to formocresol vs. ferric sulfate in pulpotomized rat teeth.
abstract: The purpose of this study was to assess histologically the pulpal healing process after pulpotomies in rat teeth were done using two different agents: 20% dilution of formocresol (FMC) and ferric sulfate (FS). Two criteria were used: degree of inflammation and extent of pulpal involvement. Zinc oxide-eugenol paste (ZOE) or polycarboxylate cement (PCX) were placed to seal the cavity preparations. The maxillary first molars of 120 Sprague-Dawley rats were treated in this study and were divided into four groups: 1) FMC + ZOE, 2) FS + PCX, 3) FMC + PCX, and 4) FS + ZOE. After treatment the animals were sacrificed at weekly intervals for four weeks and pulpal response was evaluated according to the degree of inflammation. Other criteria were also evaluated: dentinal bridge formation, reparative dentin and odontoblastic layer. A Friedman test was performed to compare the results and find out if any differences could be found. FMC + ZOE group showed the least pulpal inflammation response, and the use of FS as an alternative agent for pulpotomies did not improve pulpal response.
authors.affiliation: Dental School, University of Barcelona, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Cotes
authors.forename: J R
authors.initials: JR
authors.lastname: Boj
authors.forename: C
authors.initials: C
authors.lastname: Canalda
authors.forename: M
authors.initials: M
authors.lastname: Carreras
mesh_terms: D000818:Animals; D003782:Dental Pulp / Q000187:drug effects*; D003809:Dentin, Secondary / Q000254:growth & development; D004338:Drug Combinations; D005290:Ferric Compounds / Q000633:toxicity*; D005355:Fibrosis / Q000139:chemically induced; D005566:Formocresols / Q000633:toxicity*; D011076:Polycarboxylate Cement / Q000633:toxicity; D011671:Pulpitis / Q000139:chemically induced*; D011672:Pulpotomy / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015035:Zinc Oxide-Eugenol Cement / Q000633:toxicity
chemical_list: D004338:Drug Combinations; D005290:Ferric Compounds; D005566:Formocresols; D011076:Polycarboxylate Cement; D015035:Zinc Oxide-Eugenol Cement; C031374:zinc polyacrylate; C031025:formocresol; C024823:ferric sulfate