title: An inhibitor of aldose reductase and sorbitol accumulation from Anthocepharus chinensis.
abstract: A flavonoid glycoside was isolated from Anthocepharus chinensis. Its structure was elucidated by spectral data and determined to be myricetin 3-O-(4"-acetyl)-alpha-fucoside. This flavonoid glycoside and its aglycone showed potent inhibition against rat and porcine lens aldose reductase. The flavonoid aglycone also inhibited sorbitol accumulation in human red blood cells.
authors.forename: H
authors.initials: H
authors.lastname: Haraguchi
authors.forename: M
authors.initials: M
authors.lastname: Kanada
authors.forename: A
authors.initials: A
authors.lastname: Fukuda
authors.forename: K
authors.initials: K
authors.lastname: Naruse
authors.forename: N
authors.initials: N
authors.lastname: Okamura
authors.forename: A
authors.initials: A
authors.lastname: Yagi
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007908:Lens, Crystalline / Q000201:enzymology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013012:Sorbitol / Q000378:metabolism*; D013057:Spectrum Analysis; D013552:Swine
chemical_list: D004791:Enzyme Inhibitors; D013012:Sorbitol; D000449:Aldehyde Reductase