Ion channels and exchangers that mediate ischemic neuronal injury.
Preventing the loss of ion homeostasis or promoting its recovery are two primary targets of neuroprotective strategies. The contribution of excitatory neurotransmitter receptor linked ion channels is now well established. Sodium and calcium may also enter neurons and glia through voltage sensitive channels and exchangers, contributing directly and indirectly to injury.
Vornov
J J
JJ
Department of Neurology, Johns Hopkins Hospital, Baltimore, MD 21287-6953, USA.
D000818:Animals; D017920:Antiporters / Q000502:physiology*; D002411:Cation Exchange Resins / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D007511:Ischemia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*
D017920:Antiporters; D002411:Cation Exchange Resins; D007473:Ion Channels