title: [Immune system function in patients with acute pyelonephritis].
abstract: As many as 296 patients with acute pyelonephritis were evaluated for parameters characterizing their immunological status. The results were as follows: decreased levels of T-lymphocytes, T-helpers, and immunoregulatory index in 42%, 87% and 72% respectively. In normal indices of spontaneous test with nitroblue tetrazolium stimulated below the norm was in 71% of cases. A study involving the use of monoclonal antibodies revealed no changes in the EK-cells counts, while their functional activity was decreased in 52% of patients. The functional activity of lymphocytes in the reaction of blast transformation in response to phytohemagglutinin and PWM was running down in 83% and 75% of cases respectively. With high levels of blood serum IgA and IgM the number of the immune complexes was noted to be on the increases in 68% of patients. The level of spontaneous productions of IL-1 was normal whereas that of IL-2 elevated, with the stimulated production of there mediators in AP patients being significantly below the norm.
authors.forename: V E
authors.initials: VE
authors.lastname: Driianskaia
mesh_terms: D000208:Acute Disease; D000917:Antibody Formation; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000503:physiopathology*; D007111:Immunity, Cellular; D007375:Interleukin-1 / Q000097:blood / Q000378:metabolism; D007376:Interleukin-2 / Q000097:blood / Q000378:metabolism; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D011704:Pyelonephritis / Q000276:immunology / Q000503:physiopathology*
chemical_list: D007375:Interleukin-1; D007376:Interleukin-2
vernacular_title: Sostoianie immunnoĭ sistemy u bol'nykh ostrym pielonefritom.