An inhibitor of aldose reductase and sorbitol accumulation from Anthocepharus chinensis.
A flavonoid glycoside was isolated from Anthocepharus chinensis. Its structure was elucidated by spectral data and determined to be myricetin 3-O-(4"-acetyl)-alpha-fucoside. This flavonoid glycoside and its aglycone showed potent inhibition against rat and porcine lens aldose reductase. The flavonoid aglycone also inhibited sorbitol accumulation in human red blood cells.
Haraguchi
H
H
Kanada
M
M
Fukuda
A
A
Naruse
K
K
Okamura
N
N
Yagi
A
A
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007908:Lens, Crystalline / Q000201:enzymology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013012:Sorbitol / Q000378:metabolism*; D013057:Spectrum Analysis; D013552:Swine
D004791:Enzyme Inhibitors; D013012:Sorbitol; D000449:Aldehyde Reductase