title: Achalasia: a prospective study comparing the results of dilatation and myotomy.
abstract: OBJECTIVE
  In a prospective and randomized clinical study, the operative method and dilatation in the initial stage of megaesophagus were evaluated.
  
  
  METHODS
  Forty patients in the initial stage of megaesophagus, managed by forced hydrostatic dilatation of the cardia (20 patients-DILAT Group) or by esophagocardiomyotomy associated with esophagofundopexy (20 patients-Group OP) were followed-up for three years, in terms of clinical, radiographic, endoscopic, manometric and pH monitoring.
  
  
  RESULTS
  1) Both procedures can be performed without significant morbidity or mortality. 2) The two procedures are similar regarding ongoing suppression of dysphagia. 3) Radiologically, the methods are equivalent, since they promote significant elimination of contrast stasis and maintenance of the esophageal diameter. 4) Endoscopic follow-up did not differentiate the procedures in terms of the development of reflux esophagitis, with a rate of only 5% for each group of patients. 5) Manometry demonstrated that surgery produced a significantly greater reduction of the LESP as compared to dilatation, although the latter also determined a marked drop in the maximum basal pressure of the LES. 6) Neither procedure altered the length of the LES. 7) With prolonged esophageal pH monitoring, dilatation demonstrated a greater propensity for reflux as compared to surgery.
  
  
  CONCLUSIONS
  Both methods offer benefits in the treatment of the initial stage of megaesophagus, although esophageal pH monitoring indicates that dilatation provokes a greater index of esophageal acid exposition time.
authors.affiliation: Department Professors, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (FMUSP).
authors.forename: V N
authors.initials: VN
authors.lastname: Felix
authors.forename: I
authors.initials: I
authors.lastname: Cecconello
authors.forename: B
authors.initials: B
authors.lastname: Zilberstein
authors.forename: J P
authors.initials: JP
authors.lastname: Moraes-Filho
authors.forename: H W
authors.initials: HW
authors.lastname: Pinotti
authors.forename: E
authors.initials: E
authors.lastname: Carvalho
mesh_terms: D000328:Adult; D004106:Dilatation; D004931:Esophageal Achalasia / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D004943:Esophagogastric Junction / Q000503:physiopathology; D004947:Esophagus / Q000601:surgery*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011312:Pressure; D011446:Prospective Studies