[Effects of emoxipine and histochrome on lipid peroxidation and activity of serum MB-creatine phosphokinase in patients with ischemic heart disease during aortocoronary shunting].
Comparative study of the cardioprotective effect of antioxidants emoxipin and hystochrom was conducted in patients with chronic ICD during and after operation for aorto-coronary shunting. Both drugs effectively inhibited LPO activation and reduced the reperfusion damage to the myocardium recorded according to the release of MB-PCK into the blood. The new antioxidant hystochrom proved to be more effective. Its prevalent effect is associated with its higher antioxidant activity.
Lasukova
T V
TV
Tomsk Cardiology Institute, Research Center of Russian Academy of Medical Sciences, Russia.
Uskina
E V
EV
Afanas'iev
S A
SA
Ponomarenko
I V
IV
Naryzhnaia
N V
NV
Cherniavskiĭ
A M
AM
Lishmanov
Iu B
IuB
D000368:Aged; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001026:Coronary Artery Bypass / Q000009:adverse effects; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007527:Isoenzymes; D015227:Lipid Peroxidation / Q000187:drug effects*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D009285:Naphthoquinones / Q000494:pharmacology* / Q000627:therapeutic use; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use
D000975:Antioxidants; D007527:Isoenzymes; D009285:Naphthoquinones; D010847:Picolines; C103614:histochrome; D003402:Creatine Kinase; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Vliianie émoksipina i gistokhroma na protsess perekisnogo okisleniia lipidov i aktivnost' MB-kreatinfosfokinazy syvorotki krovi bol'nykh ishemicheskoĭ bolezn'iu serdtsa v dinamike operatsii aorto-koronarnogo shuntirovaniia.