Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer.
We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). There was no difference between the two groups, suggesting that specific haplotypes are not required for the development of the "anti-Hu syndrome."
Uchuya
M
M
Department of Neurology, Hôpital de la Salpêtrière, Paris, France.
Fleury
A
A
Graus
F
F
Costagliola
D
D
Liblau
R
R
Merle-Beral
H
H
Théodorou
I
I
Delattre
J Y
JY
D000483:Alleles; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000276:immunology*; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology*; D009422:Nervous System Diseases / Q000235:genetics / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000276:immunology*
D001323:Autoantibodies; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains