title: Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone.
abstract: The secretion pattern of putuitary growth hormone (GH) in rodents is sexually dimorphic and regulates the expression of some hepatic genes. We report cloning of mouse glycine N-methyltransferase (GNMT) cDNA. The mouse GNMT mRNA is expressed at much lower levels in male than in female livers. Hypophysectomy in male mice resulted in as a high level of the expression as in female mice. Treatment with GH of hypophysectomized male mice twice a day for 5 days decreased the expression. These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns.
authors.affiliation: Third Department of Internal Medicine, Yamanashi Medical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Aida
authors.forename: M
authors.initials: M
authors.lastname: Tawata
authors.forename: M
authors.initials: M
authors.lastname: Negishi
authors.forename: T
authors.initials: T
authors.lastname: Onaya
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D050938:Glycine N-Methyltransferase; D013006:Growth Hormone / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008780:Methyltransferases / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012727:Sex Characteristics
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger; D013006:Growth Hormone; D008780:Methyltransferases; D050938:Glycine N-Methyltransferase; C494511:Gnmt protein, mouse