Platelet serotonin and interleukin-1 beta after sleep deprivation and recovery sleep in humans.
Sleep deprivation (SD) represents a well-established therapy for major depression. Recent findings suggest that the antidepressive effects of sleep deprivation are mediated at least in part by pro-serotoninergic mechanisms. Furthermore, SD has been demonstrated to modify different host defense activities. We therefore investigated the serotonin (5-HT) content in platelets, platelet density distribution and 5-HT-induced IL-1 beta release from platelets in 10 healthy men before and after total SD (TSD) as well as after recovery sleep. Blood samples were drawn on 3 consecutive days at 7.00 h, 13.00 h, and 19.00 h, respectively. In addition, the psychophysiological parameters tiredness and wakefulness were assessed. After TSD the normal daily variation of IL-1 beta release with high morning levels and low evening levels was found to be significantly inverted. The release of IL-1 beta corresponded positively to the subjectively experienced tiredness of the probands. Analysis of platelet density distribution indicated a significant daily variation of low density platelets with low levels in the morning and high levels in the evening, which was absent after TSD. Our findings favour an increased pro-serotoninergic effect after TSD, which comprises respective variations of the host defense system, but is abolished by consecutive recovery sleep.
Heiser
P
P
Institute of Physiological Chemistry, Philipps University, Marburg, Federal Republic of Germany.
Dickhaus
B
B
Opper
C
C
Schreiber
W
W
Clement
H W
HW
Hasse
C
C
Hennig
J
J
Krieg
J C
JC
Wesemann
W
W
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm / Q000502:physiology; D005221:Fatigue / Q000523:psychology; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D010976:Platelet Count; D012701:Serotonin / Q000097:blood*; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000502:physiology*
D007375:Interleukin-1; D012701:Serotonin