Half corneal light shield as a delivery system for standardized application of mitomycin C.
OBJECTIVE
The authors develop a simple and economical method of applying reproducible intraoperative doses of mitomycin C for glaucoma filtering surgery.


METHODS
A three-part protocol was developed to study several properties of half corneal light shields (HCLSs). Part A tested the amount of mitomycin C (0.4 mg/ml) absorbed, the expansion dimensions attained, and the amount released to filter paper. In part B, the in vitro release of mitomycin C to an enucleated pig eye was examined. In part C, the in vivo release during intraoperative filtering surgery was tested.


RESULTS
The amount of mitomycin C solution absorbed by the HCLSs ranged from 1.07 x 10(-2) mg to 1.19 x 10(-2) mg; expansion width ranged from 6.8 mm to 7.0 mm; expansion height ranged from 3.6 mm to 3.8 mm; expansion thickness was constant at 0.6 mm. The amount of solution released to filter paper ranged from 6.8 x 10(-3) mg to 8.6 x 10(-3) mg. The amount of solution transferred to the pig eye ranged from 1.0 x 10(-3) mg to 2.7 x 10(-3) mg. The amount of solution released in filtering surgery ranged from 2.0 x 10(-3) mg to 4.8 x 10(-3) mg.


CONCLUSIONS
The contact surface area, the amount absorbed, and the amount released by each HCLS was reproducible. The uniform thickness theoretically provides a uniform distribution of mitomycin C. This method may allow standardization of intraoperative mitomycin C application, and may reduce the incidence of complications.
Khoury
J M
JM
Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-8808, USA.
Joos
K M
KM
Shen
J H
JH
Davis
D
D
O'Day
D M
DM
D000042:Absorption; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D003315:Cornea / Q000187:drug effects / Q000378:metabolism; D016503:Drug Delivery Systems / Q000592:standards; D018463:Filtering Surgery; D005901:Glaucoma / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007432:Intraoperative Period; D016685:Mitomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D015203:Reproducibility of Results; D013552:Swine
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin