[Comparative study of DNA-repair ability of lymphocytes from systemic lupus erythematosus and rheumatoid arthritis patients].
Induction of DNA breaks with 4-NQO and their resynthesis in the cultivated lymphocytes of peripheral blood of 23 patients with systemic lupus erythematosus (SLE) and 12 patients with rheumatoid arthritis (RA) were studied by the method of hydroxyapatite column chromatography of cell lysates. The number of spontaneous DNA breaks was shown to increase in 48% of patients with SLE and in 42% of patients with RA, compared to that in the control. Inhibition of the repair process was observed in 35% of patients with SLE and in 17% of patients with RA. Complete repair of DNA breaks was observed in 67% of patients with RA and only in 26% of patients with SLE.
Vasil'eva
I M
IM
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Lisitsina
T A
TA
Durnev
A D
AD
Ivanova
M M
MM
Zasukhina
G D
GD
D015112:4-Nitroquinoline-1-oxide / Q000633:toxicity; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D002853:Chromatography, Liquid; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008214:Lymphocytes / Q000378:metabolism*; D009153:Mutagens / Q000633:toxicity
D009153:Mutagens; D015112:4-Nitroquinoline-1-oxide
Sravnitel'noe issledovanie DNA-repariruiushcheĭ sposobnosti limfotsitov bol'nykh sistemnoĭ krasnoĭ volchankoĭ i revmatoidnym artritom.