Fenoterol increases erythropoietin concentrations during tocolysis.
OBJECTIVE
The present study was carried out to assess the effect of the selective beta2-adrenoceptor agonists on erythropoietin (EPO) production.


METHODS
Routine tocolysis with fenoterol (using the regular rate of 2 microg min[-1]) was used as a clinically easily accessible model.


RESULTS
EPO concentrations had doubled 24 h after the start of tocolysis (P < 0.001). This increase lasted over the entire observation period of 48 h. Potassium concentrations fell significantly during the first hours of fenoterol infusion. There was no increase of human placenta lactogen during the period of EPO increase.


CONCLUSIONS
The data confirm our earlier results that fenoterol increases EPO concentrations following haemorrhage. In this model it was not necessary to stimulate EPO production prior to pharmacological treatment.
Gleiter
C H
CH
Abteilung Klinische Pharmakologie, George-August-Universität, Göttingen, Germany.
Schreeb
K H
KH
Goldbach
S
S
Herzog
S
S
Cunze
T
T
Kuhn
W
W
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000328:Adult; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood; D007752:Obstetric Labor, Premature / Q000188:drug therapy / Q000517:prevention & control; D010928:Placental Lactogen / Q000097:blood / Q000187:drug effects; D011188:Potassium / Q000097:blood; D011247:Pregnancy; D013997:Time Factors; D015145:Tocolysis; D015149:Tocolytic Agents / Q000627:therapeutic use; D014168:Transferrin / Q000187:drug effects / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D006454:Hemoglobins; D015149:Tocolytic Agents; D014168:Transferrin; D004921:Erythropoietin; D005280:Fenoterol; D010928:Placental Lactogen; D007501:Iron; D011188:Potassium