title: Mouse muscle regeneration: an in vivo 2D 1H magnetic resonance spectroscopy (MRS) study.
abstract: Muscle degeneration and regeneration were studied by 2D 1H magnetic resonance spectroscopy (MRS) and histological examination, in an experimental model of muscle injury using a myotoxic snake venom, notexin. The injured muscles produced a very specific MRS signal, corresponding to a tri-unsaturated fatty acid (linolenic acid-like) signal, from day 2 to day 9 after injury. The combination of MRS with histology showed that this signal was associated with a mechanism occurring during myoblast fusion to form myotubes. 2D 1H MRS is thus a useful non-invasive tool for detecting muscle regeneration in vivo.
authors.affiliation: Laboratoire de RMN biologique, ICSN, CNRS, Gif sur Yvette, France. cathy.sebrie@icsn.cnrs-gif.fr
authors.lastname: Sébrié
authors.forename: B
authors.initials: B
authors.lastname: Gillet
authors.forename: J P
authors.initials: JP
authors.lastname: Lefaucheur
authors.forename: A
authors.initials: A
authors.lastname: Sébille
authors.forename: J C
authors.initials: JC
authors.lastname: Beloeil
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012038:Regeneration / Q000502:physiology*