[The antianginal activity of angiotensin-converting enzyme inhibitors].
The authors studied an antianginal effect of the angiotensin-converting enzyme, for which purpose they used Capoten at 75 mg daily over two weeks in 24 patients with stable functional class II-III exertional angina. Capoten was shown to be capable of reducing occurrences of angina attacks as well as intakes of tablets of nitroglycerin for the above attacks to be arrested; besides, it lowers systolic and diastolic arterial pressure, enhances exercise tolerance, increase rate of circular shortening of left ventricular myocardium fibres, decreases total peripheral vascular resistance. In conclusion, apart from antihypertensive and positive inotropic action Capoten has a coranolytic effect.
Cherevatov
B G
BG
Shelest
A N
AN
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use*; D004341:Drug Evaluation; D004562:Electrocardiography / Q000187:drug effects; D017079:Exercise Tolerance / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril
Antianginal'naia aktivnost' ingibitorov angiotenzinprevrashchaiushchego fermenta.