title: Circulating immune complexes from HIV-1+ patients induces apoptosis on normal lymphocytes.
abstract: Isolated immune complexes from sera of 49 out of 67 human immunodeficiency virus-1-positive (HIV-1+) patients (CIC-HIV+), composed of anti-HIV-HIV-Ag, could induce apoptosis on normal phytohaemagglutinin (PHA)-activated lymphocytes. DNA degradation was detected by propidium iodide staining. This activity is directed against CD4+ lymphocytes as demonstrated by double binding of CIC-HIV+ and anti-CD4 on apoptosis cells. Expression of Fas antigen is prior to apoptotic phenomena. CIC-HIV+ apoptosis inducers belong mainly to asymptomatic HIV-infected patients, indicating that immune complexes from these patients can destroy CD4+ lymphocytes.
authors.affiliation: Department of Immunology, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Aceituno
authors.forename: S
authors.initials: S
authors.lastname: Castañón
authors.forename: C
authors.initials: C
authors.lastname: Jiménez
authors.forename: D
authors.initials: D
authors.lastname: Subirá
authors.forename: M
authors.initials: M
authors.lastname: De Górgolas
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Guerrero
authors.forename: F
authors.initials: F
authors.lastname: Ortíz
authors.forename: R
authors.initials: R
authors.lastname: García
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D017209:Apoptosis / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018929:Cell Culture Techniques; D005260:Female; D006679:HIV Seropositivity / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D019014:fas Receptor / Q000097:blood
chemical_list: D000936:Antigen-Antibody Complex; D019014:fas Receptor