title: A case of chronic myelomonocytic leukemia with isochromosome 14q.
abstract: A 72-year-old man with increased monocytes and eosinophils in the bone marrow was found to have an isochromosome, i(14q), as the sole abnormality on bone-marrow cytogenetics. Follow-up over 12 months with repeat cytogenetic testing of bone marrow specimens on three further occasions showed an additional abnormality consisting of an apparently balanced translocation, t(6;21)(p21.1; q22). This abnormality, together with other features, indicated disease progression. A review of seven reported cases of i(14q) revealed limited follow-up information.
authors.affiliation: Department of Cytogenetics, Royal Alexandra Hospital, Westmead, New South Wales, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Flaherty
authors.forename: A
authors.initials: A
authors.lastname: Jarvis
authors.forename: M
authors.initials: M
authors.lastname: Harris
authors.forename: V
authors.initials: V
authors.lastname: Tyrrell
authors.forename: A
authors.initials: A
authors.lastname: Smith
mesh_terms: D000368:Aged; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D018404:Isochromosomes; D007621:Karyotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D013997:Time Factors