title: The cytomorphologic features of sclerosing mucoepidermoid carcinoma of the thyroid gland with eosinophilia.
abstract: Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a recently described carcinoma of the thyroid gland associated with Hashimoto's thyroiditis and considered to have a relatively indolent clinical course. We describe two patients with SMECE and its aspiration and exfoliative cytologic features. Patient 1 was a 39-year-old woman with a goiter for many years. Examination of the lobectomy specimen revealed SMECE associated with Hashimoto's disease; 4 months later a total thyroidectomy was performed, metastases were found in nine lymph nodes in the neck. Two years later, fine-needle aspiration biopsy (FNAB) of a paritracheal mass revealed recurrent tumor. After 2 more years, two pleural fluid samples contained metastatic carcinoma with eosinophils. Patient 2 was a 61-year-old man with thyromegaly and vocal cord paralysis. The FNAB revealed a poorly differentiated carcinoma. The subsequent thyroidectomy demonstrated SMECE. Two years later, an FNAB of a vertebral mass demonstrated metastatic mucoepidermoid carcinoma. In all specimens, malignant cells with definite glandular and squamoid differentiation were present in small cohesive aggregates; eosinophils associated with the tumor cells were present in all specimens.
authors.affiliation: Department of Pathology, Wake Forest University and the Baptist Hospital Medical Center, Winston-Salem, North Carolina, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Geisinger
authors.forename: C H
authors.initials: CH
authors.lastname: Steffee
authors.forename: R S
authors.initials: RS
authors.lastname: McGee
authors.forename: R D
authors.initials: RD
authors.lastname: Woodruff
authors.forename: D H
authors.initials: DH
authors.lastname: Buss
mesh_terms: D000328:Adult; D018277:Carcinoma, Mucoepidermoid / Q000150:complications / Q000473:pathology* / Q000556:secondary; D004802:Eosinophilia / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000473:pathology; D012598:Sclerosis / Q000473:pathology; D013125:Spinal Neoplasms / Q000473:pathology / Q000556:secondary; D013904:Thoracic Vertebrae / Q000473:pathology; D013964:Thyroid Neoplasms / Q000150:complications / Q000473:pathology*; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000473:pathology*