Pharmacological screening of different Juniperus oxycedrus L. extracts.
Methanol and dichloromethanol extracts of leaves and stems of Juniperus oxycedrus have been tested for their toxicity, analgesic, antiinflammatory and central effects. Both extracts showed low acute toxicity and decreased spontaneous motility. The methanol extract exhibited an analgesic effect in models of chemical, mechanical and thermal stimulation whereas dichloromethanol extract showed only a significant effect in models of pain induced by chemical stimulation. Both extracts showed a significant antiinflammatory activity and inhibition of the rat paw oedema induced by carrageenin.
Moreno
L
L
Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain.
Bello
R
R
Beltrán
B
B
Calatayud
S
S
Primo-Yúfera
E
E
Esplugues
J
J
D000818:Animals; D005260:Female; D007249:Inflammation / Q000188:drug therapy; D018653:Juniperus / Q000737:chemistry / Q000627:therapeutic use; D008297:Male; D000432:Methanol; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D000432:Methanol