Alternative therapies for vasculitis and proliferative nephritides: the role of cyclic AMP elevating agents.
Cytoprotection by E-prostaglandins, working by elevation of intracellular cyclic AMP, is a natural physiological mechanism. When agents that elevate cAMP are used in pharmacological regimens they have potent anti-inflammatory effects that could be used to good effect as adjuncts for the control of vasculitides/nephritides.
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D000241:Adenosine / Q000502:physiology; D000527:Alprostadil / Q000627:therapeutic use; D000242:Cyclic AMP / Q000502:physiology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D009393:Nephritis / Q000188:drug therapy* / Q000628:therapy; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D014657:Vasculitis / Q000188:drug therapy* / Q000628:therapy
D016756:Immunoglobulins, Intravenous; D010726:Phosphodiesterase Inhibitors; D000242:Cyclic AMP; D000527:Alprostadil; D000241:Adenosine