Survival time in mice bearing TLX5 lymphoma subjected to rotational stress and chemotherapy with CCNU.
The effects of a psychological stress model rotational stress were examined in mice bearing TLX5 lymphoma. The survival time of the animals was determined as a function of tumor inoculum size and treatment with the antitumor drug, CCNU. Rotational stress significantly decreased the mean survival time of mice implanted with 10 or 10(2) tumor cells, and significantly increased tumor takes in mice implanted with 10 cells. Treatment with CCNU significantly prolonged the survival time of the treated animals; the application of rotational stress significantly attenuated the increase in survival time caused by CCNU. These results indicate that in mice with a limited tumor burden, psychological stress favors the progression of TLX5 lymphoma, and reduces the effectiveness of the antitumor drug, CCNU. Moreover, the experimental model employed may provide a tool useful for investigating the mechanisms involved in the sensitivity of lymphoma to psychosocial stress.
Perissin
L
L
Department of Biomedical Sciences and Technologies, University of Udine, Italy. laura.perissin@kolbe.drmm.uniud.it
Rapozzi
V
V
Zorzet
S
S
Giraldi
T
T
D000818:Animals; D005260:Female; D008130:Lomustine / Q000627:therapeutic use*; D008223:Lymphoma / Q000188:drug therapy* / Q000401:mortality / Q000523:psychology*; D051379:Mice; D008808:Mice, Inbred CBA; D012399:Rotation; D013315:Stress, Psychological; D016019:Survival Analysis
D008130:Lomustine