title: Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development.
abstract: This is the first in situ hybridization analysis of expression of a tumor necrosis factor (TNF) receptor associated factor (TRAF) during development. TRAF4 is observed throughout mouse embryogenesis, most notably during ontogenesis of the central (CNS) and peripheral (PNS) nervous system, and of nervous tissues of sensory organs. TRAF4 is preferentially expressed by post-mitotic undifferentiated neurons. Interestingly, TRAF4 remains expressed in the adult hippocampus and olfactory bulb, known to contain multipotential cells responsible for neoneurogenesis.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Strasbourg, France.
authors.forename: R
authors.initials: R
authors.lastname: Masson
authors.forename: C H
authors.initials: CH
authors.lastname: Régnier
authors.forename: M P
authors.initials: MP
authors.lastname: Chenard
authors.forename: C
authors.initials: C
authors.lastname: Wendling
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: C
authors.initials: C
authors.lastname: Tomasetto
authors.forename: M C
authors.initials: MC
authors.lastname: Rio
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008938:Mitosis / Q000235:genetics; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics*; D009420:Nervous System / Q000196:embryology / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics*; D011506:Proteins; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D053449:TNF Receptor-Associated Factor 4; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
chemical_list: D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D011506:Proteins; D018124:Receptors, Tumor Necrosis Factor; D053449:TNF Receptor-Associated Factor 4; C506368:Traf4 protein, mouse; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins