Antigen processing: HLA-DO--a hitchhiking inhibitor of HLA-DM.
Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules.
Jensen
P E
PE
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA. pjensen@bimcore.emory.edu
D017951:Antigen Presentation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002384:Catalysis; D006681:HLA-D Antigens / Q000276:immunology*; D000949:Histocompatibility Antigens Class II; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology
C416186:H-2O antigen; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; C046148:HLA-DO antigens; D000949:Histocompatibility Antigens Class II