title: Histological, clinical, and digital subtraction radiographic evaluation of repair of periodontal defects resulting from mechanical perforation of the chamber floor using ePTFE membranes.
abstract: The aim of this study was to test the hypothesis that a biocompatible membrane, when placed between the gingiva and cortical bone in teeth with periodontal defects that occurred following mechanical endodontic perforation, would facilitate greater regeneration than in control sites not treated with guided tissue regeneration. One beagle dog with a healthy periodontium was used in the study. The maxillary right first and second molars and the mandibular left first and second molars acted as the experimental group in which furcation perforations were treated by guided tissue regeneration. The maxillary left and mandibular right first and second molars served as the controls in which furcation perforation lesions were only treated by open flap debridement. Clinical, histological, and standardized radiographic evaluation showed significant differences between the test and control groups. In addition, digital subtraction radiography revealed a gain in alveolar bone height and increased density at all experimental sites, and a loss at all control sites. Histological evaluation showed extensive regeneration of both alveolar bone and connective tissue at experimental sites, but none at control sites. The results of this study suggest that the use of guided tissue regeneration in furcation lesions produced by endodontic perforations will result in significant new bone and connective tissue attachment.
authors.affiliation: Department of Periodontics, University of Medicine and Dentistry of New Jersey, New Jersey Dental School, Newark 07103-2425, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Leder
authors.forename: B I
authors.initials: BI
authors.lastname: Simon
authors.forename: M
authors.initials: M
authors.lastname: Deasy
authors.forename: K E
authors.initials: KE
authors.lastname: Fenesy
authors.forename: S
authors.initials: S
authors.lastname: Dunn
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004195:Disease Models, Animal; D004285:Dogs; D017823:Furcation Defects / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods / Q000706:statistics & numerical data; D008567:Membranes, Artificial; D010519:Periodontium / Q000473:pathology; D011138:Polytetrafluoroethylene; D019252:Radiography, Dental, Digital / Q000706:statistics & numerical data; D013382:Subtraction Technique
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene