title: Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats.
abstract: Laminar profiles of rises in [K+]o and slow field potentials induced by alvear stimulation were recorded in area CA1 of hippocampal slices from control and pilocarpine-treated rats in absence and presence of Ba2+. In control animals, Ba2+ augmented rises in [K+]o in stratum pyramidale (SP) as well as in stratum radiatum (SR). In pilocarpine-treated animals an augmentation of rises in [K+]o was restricted to SP and its immediate vicinity. Moreover, the effect of Ba2+ in SP was small or missing in eight out of 15 slices of pilocarpine-treated animals. In these slices laminar profiles of rises in [K+]o were not affected by Ba2+. It is suggested that spatial K+-buffering is reduced in area CA1 of epileptic animals.
authors.affiliation: Abt. Neurophysiologie, Institut für Physiologie, Universitätsklinikum Charité/Virchow-Klinikum, Humboldt-Universität zu Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Gabriel
authors.forename: A
authors.initials: A
authors.lastname: Eilers
authors.forename: A
authors.initials: A
authors.lastname: Kivi
authors.forename: R
authors.initials: R
authors.lastname: Kovacs
authors.forename: K
authors.initials: K
authors.lastname: Schulze
authors.forename: T N
authors.initials: TN
authors.lastname: Lehmann
authors.forename: U
authors.initials: U
authors.lastname: Heinemann
mesh_terms: D000818:Animals; D001464:Barium / Q000494:pharmacology*; D004833:Epilepsy, Temporal Lobe / Q000139:chemically induced / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D010862:Pilocarpine / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000494:pharmacology
chemical_list: D010862:Pilocarpine; D001464:Barium; D012601:Scopolamine; D011188:Potassium