title: Immunogenicity study of Haemophilus influenzae type B conjugate vaccine in Indian infants.
abstract: OBJECTIVE
  To assess the immunogenicity in Indian infants to Haemophilus influenzae b oligosaccharide conjugate vaccine (HbOC).
  
  
  METHODS
  Prospective multicenter study.
  
  
  METHODS
  Pediatric Out Patient Department of general hospitals in Pune and Mumbai.
  
  
  METHODS
  124 full term healthy infants brought for routine DPT/OPV immunization.
  
  
  METHODS
  Infants were administered 3 doses of 0.5 ml of HbOC, on the same day as their DPT/OPV immunization, injected intramuscularly on the limb opposite to that where DPT vaccine was administered. Data on local reactions and general symptoms was collected for three days after every dose. The children had their blood collected for assay of anti PRP (polyribosil ribitol phosphate) antibody titers, along with the first injection and one month after the third injection. One hundred and three infants completed the study protocol with two blood collections.
  
  
  RESULTS
  The initial geometric mean titers (GMT) of 0.124 mcg/ml rose by 37 times to 4.552 mcg/ml. Ninety eight children (95.1%) had a final titer of > or = 0.15 mcg/ml, the minimum level associated with protection, and 77 children (74.8%) had a final level of > or = 1.0 mcg/ml, a level associated with long term protection.
  
  
  CONCLUSIONS
  HbOC is immunogenic in Indian infants when used as per the locally recommended DPT/OPV immunization schedule.
authors.affiliation: Department of Pediatrics, B.J. Medical College, Pune.
authors.forename: M A
authors.initials: MA
authors.lastname: Phadke
authors.forename: M V
authors.initials: MV
authors.lastname: Kulkarni
authors.forename: V B
authors.initials: VB
authors.lastname: Sovani
authors.forename: M R
authors.initials: MR
authors.lastname: Lokeshwar
authors.forename: R
authors.initials: R
authors.lastname: Venkataraman
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis*; D016667:Bacterial Capsules; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology* / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000276:immunology; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007109:Immunity; D007115:Immunization Schedule; D007194:India; D007223:Infant; D008297:Male; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage* / Q000276:immunology; D011446:Prospective Studies
chemical_list: D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial