title: [Antipyrine test in evaluation of patient's hepatic failure in early postoperative period].
abstract: In victims of severe combined trauma in early postoperative period there are disorders in the system of monooxygenase detoxication of hepatocytes--the duration of antipyrine semiexcretion period in the blood was 2.5 times longer than in healthy people. In 40% of injured parallelism in changes of values of the antipyrine test and general blood bilirubin are detected; in 18% of cases hyperbilirubinemia is revealed in antipyrine clearence being normal, and in 42% a sharp decrease of antipyrine clearence at the background of normal bilirubin content is detected. Hypoproteinemia, hypoalbuminuria, and activation of ALT and AST was revealed, which evidenced of the reaction of urgent adaptation. Under conditions of development of the postoperative stress-reaction the examination of monooxygenaze system of hepatocytes' detoxication is the most specific test of revealing early hepatic insufficiency. A sharp decrease or increase of antipyrine clearence is a sign of irreversibility of hepatic insufficiency.
authors.forename: N S
authors.initials: NS
authors.lastname: Nemchenko
authors.forename: V K
authors.initials: VK
authors.lastname: Vagner
authors.forename: O N
authors.initials: ON
authors.lastname: Erashev
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics; D000983:Antipyrine / Q000493:pharmacokinetics; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D006801:Humans; D017093:Liver Failure / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D009104:Multiple Trauma / Q000601:surgery*; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D011184:Postoperative Period; D012680:Sensitivity and Specificity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D001663:Bilirubin; D000983:Antipyrine
vernacular_title: Antipirinovaia proba v otsenke pechenochnoĭ nedostatochnosti u bol'nykh v rannem posleoperatsionnom periode.