title: Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy.
abstract: Two children with acquired immunodeficiency syndrome (AIDS) and progressive encephalopathy underwent MR spectroscopy before and after antiretroviral therapy. Initial MR spectroscopy of the basal ganglia region showed decreased N-acetylaspartate (NAA)/creatine (Cr) and a lactate peak. After therapy, there was improvement in NAA/Cr and an absence of the abnormal lactate peak. We suggest that decreased NAA/Cr in AIDS is reversible, that brain lactate might correlate with inflammation, and that MR spectroscopy can be useful in treatment trials.
authors.affiliation: Department of Neurology, New York University School of Medicine, North Shore University Hospital, Manhasset 11030, USA.
authors.forename: S G
authors.initials: SG
authors.lastname: Pavlakis
authors.forename: D
authors.initials: D
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Frank
authors.forename: A
authors.initials: A
authors.lastname: Wiznia
authors.forename: D
authors.initials: D
authors.lastname: Eidelberg
authors.forename: T
authors.initials: T
authors.lastname: Barnett
authors.forename: R A
authors.initials: RA
authors.lastname: Hyman
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000188:drug therapy; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003401:Creatine / Q000378:metabolism; D016049:Didanosine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D001224:Aspartic Acid; D019344:Lactic Acid; D015215:Zidovudine; C000179:N-acetylaspartate; D016049:Didanosine; D003401:Creatine