title: Inteins in mycobacterial GyrA are a taxonomic character.
abstract: The A subunit of DNA gyrase in mycobacteria is frequently subjected to splicing events as its gene, gyrA, harbours an insertion encoding an intein. Investigation of a number of different isolates of Mycobacterium kansasii, Mycobacterium malmoense, Mycobacterium marinum, Mycobacterium ulcerans and Mycobacterium xenopi demonstrated that the presence of GyrA inteins is not random but a taxonomic character specific for a given taxon at a species or subspecies level.
authors.affiliation: Institut für Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Sander
authors.affiliation: Département de Medicine Interne, Division des Maladies Infectieuses, CHUV-1011 Lausanne, Switzerland.
authors.forename: Fernando
authors.initials: F
authors.lastname: Alcaide
authors.affiliation: Institut für Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Richter
authors.affiliation: Institut für Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Frischkorn
authors.affiliation: Bacteriological and Virological Laboratory, Careggi Hospital, 50139 Firenze, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Tortoli
authors.affiliation: Institut für Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Burkhard
authors.initials: B
authors.lastname: Springer
authors.affiliation: Département de Medicine Interne, Division des Maladies Infectieuses, CHUV-1011 Lausanne, Switzerland.
authors.forename: Amalio
authors.initials: A
authors.lastname: Telenti
authors.affiliation: Institut für Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
authors.forename: Erik C
authors.initials: EC
authors.lastname: Böttger
mesh_terms: D001426:Bacterial Proteins / Q000032:analysis* / Q000235:genetics*; D002965:Classification; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D008969:Molecular Sequence Data; D009161:Mycobacterium / Q000145:classification* / Q000235:genetics; D009170:Nontuberculous Mycobacteria / Q000145:classification* / Q000235:genetics; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S; C093709:pps1 protein, Mycobacterium sp.; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II