Cartilage macromolecules in knee joint synovial fluid. Markers of the disease course in patients with acute oligoarthritis.
OBJECTIVE
To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms.


METHODS
Retrospective follow up of 25 patients identified in a bank of knee joint synovial fluids collected consecutively from patients presenting with knee joint synovitis and symptoms from at most three additional joints and in whom no diagnosis could be established at presentation.


RESULTS
The 10 patients who developed chronic joint symptoms were characterised by lower knee joint synovial fluid concentrations of aggrecan as well as lower aggrecan/COMP ratios (p < 0.001) than the 15 patients who had a transient arthritis. No other clinical or laboratory differences between the groups were apparent at the time of presentation.


CONCLUSIONS
The synovial fluid content of aggrecan is a potential tool in acute arthritis for distinguishing patients with a benign disease course from those who will develop a chronic joint disorder.
Lindqvist
E
E
Department of Rheumatology, Lund University Hospital, Sweden.
Saxne
T
T
D000208:Acute Disease; D000328:Adult; D000368:Aged; D053674:Aggrecans; D001168:Arthritis / Q000378:metabolism*; D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism; D002908:Chronic Disease; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007719:Knee Joint / Q000378:metabolism*; D037181:Lectins, C-Type; D008297:Male; D064235:Matrilin Proteins; D008875:Middle Aged; D011379:Prognosis; D011509:Proteoglycans / Q000378:metabolism*; D012189:Retrospective Studies; D013582:Synovial Fluid / Q000378:metabolism*
D053674:Aggrecans; D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D011508:Chondroitin Sulfate Proteoglycans; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D037181:Lectins, C-Type; D064235:Matrilin Proteins; D011509:Proteoglycans; C577553:TSP5 protein, human