The clinical significance of T-cell superantigens.
Superantigens are a diverse collection of molecules that share the ability to activate specific lymphocyte subsets. In animal models, many of these molecules delete T-cell populations or render them anergic. The clinical impact of superantigens is significant, but much of their pathophysiology remains unclear.
Michie
C A
CA
Dept of Paediatrics, Ealing Hospital NHS Trust, Middlesex, UK. colinm@easynet.co.uk
Cohen
J
J
D000818:Animals; D017635:Clonal Anergy; D017637:Clonal Deletion; D004194:Disease / Q000209:etiology; D006801:Humans; D051379:Mice; D018448:Models, Immunological; D018089:Superantigens / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D018089:Superantigens