title: In vivo MRI thermometry using a phase-sensitive sequence: preliminary experience during MRI-guided laser-induced interstitial thermotherapy of brain tumors.
abstract: The purpose of this study was the application of the proton-resonance-frequency method to monitor laser-induced interstitial thermotherapy (LITT) in a patient with an astrocytoma WHO II. A phase-sensitive two-dimensional (2D) fast low-angle shot (FLASH) sequence was used to determine the temperature-related phase shifts during LITT. Temperature maps were displayed during therapy with a temporal resolution of 20 seconds. Irradiation was discontinued as soon as the 60 to 65 degrees C isotherm reached the margin of the tumor. A contrast-enhanced MRI study performed immediately after therapy showed a good correlation of the size of an enhancing rim around the lesion with the 60 to 65 degrees C isotherm. The preliminary results of our study indicate that MRI guidance of LITT may be improved by temperature quantification based on the proton-resonance-frequency method.
authors.affiliation: Institute of Diagnostic Radiology, Heinrich-Heine-University, Düsseldorf, Germany. kahn@mr.uni-duesseldorf.de
authors.forename: T
authors.initials: T
authors.lastname: Kahn
authors.forename: T
authors.initials: T
authors.lastname: Harth
authors.forename: J C
authors.initials: JC
authors.lastname: Kiwit
authors.forename: H J
authors.initials: HJ
authors.lastname: Schwarzmaier
authors.forename: C
authors.initials: C
authors.lastname: Wald
authors.forename: U
authors.initials: U
authors.lastname: Mödder
mesh_terms: D001254:Astrocytoma / Q000473:pathology / Q000628:therapy*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053685:Laser Therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015642:Radiology, Interventional