Distribution of the alpha7 nicotinic acetylcholine receptor subunit in the developing chick cerebellum.
Previous studies of the nicotinic acetylcholine receptor (nAChR) subunits in adult mammalian and avian brains have demonstrated a spatially restricted distribution of these subunits; little, however, is known about the nAChR subunit developmental distribution. The present study demonstrated a transient pattern of distribution of the neuronal nAChR subunit, alpha7, in the developing chick cerebellum by using immunohistochemical techniques. This transient distribution may suggest a critical period for the development of the cholinergic system in the cerebellum.
Kaneko
W M
WM
Department of Neurosciences, University of California, San Diego, La Jolla 92093-0608, USA. wkaneko@ucsd.edu
Britto
L R
LR
Lindstrom
J M
JM
Karten
H J
HJ
D000818:Animals; D000911:Antibodies, Monoclonal; D002531:Cerebellum / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D002645:Chickens / Q000502:physiology*; D007150:Immunohistochemistry; D011689:Purkinje Cells / Q000502:physiology; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D011978:Receptors, Nicotinic