Unique cytomegalovirus intracytoplasmic inclusions in ectocervical cells on a cervical/endocervical smear.
This case demonstrates unique cytomegalovirus (CMV)-associated intracytoplasmic inclusions in the intermediate squamous cells of a cervical/endocervical smear. These concentric, rod-shaped, perinuclear inclusions were stained for CMV by immunohistochemistry. Cytomegalovirus endocervicitis was also documented on a concurrent cervical biopsy. The finding of these characteristic inclusions on a routine endocervical/cervical smear may provide morphologic evidence for CMV infection in the absence of an adequate endocervical component.
Hunt
J L
JL
Department of Pathology, University of Pennsylvania Medical Center, Philadelphia 19101, USA.
Baloch
Z
Z
Judkins
A
A
LiVolsi
V A
VA
Montone
K T
KT
Gupta
P K
PK
D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D003593:Cytoplasm / Q000378:metabolism / Q000473:pathology / Q000821:virology; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007181:Inclusion Bodies, Viral / Q000378:metabolism / Q000473:pathology*; D002575:Uterine Cervicitis / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D014626:Vaginal Smears; D014764:Viral Proteins / Q000378:metabolism
D014764:Viral Proteins