A case of chronic myelomonocytic leukemia with isochromosome 14q.
A 72-year-old man with increased monocytes and eosinophils in the bone marrow was found to have an isochromosome, i(14q), as the sole abnormality on bone-marrow cytogenetics. Follow-up over 12 months with repeat cytogenetic testing of bone marrow specimens on three further occasions showed an additional abnormality consisting of an apparently balanced translocation, t(6;21)(p21.1; q22). This abnormality, together with other features, indicated disease progression. A review of seven reported cases of i(14q) revealed limited follow-up information.
Flaherty
L
L
Department of Cytogenetics, Royal Alexandra Hospital, Westmead, New South Wales, Australia.
Jarvis
A
A
Harris
M
M
Tyrrell
V
V
Smith
A
A
D000368:Aged; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D018404:Isochromosomes; D007621:Karyotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D013997:Time Factors