[Artificial pressure increase in subcutaneous abscess with evidence of general systemic reaction].
Abscess is customarily thought of as a collection of a large number of microorganisms, inflammatory cells and necrotic debris separated from the surrounding tissue by a fibrous capsule. Modern work focussed attention on more physico-chemical parameters in abscess pathogenesis. Recent experiences from animal models underline the impact of abscess pressure and bio-physicochemical parameters in the "abscess compartment" for systemic spreading. Artificial raising of abscess-pressure in pigs up to 80 mmHg was followed by increase of temperature and heartbeat rate and decrease of median arterial pressure. Elevated levels of TNF alpha, IL-1 and positive blood cultures support the theory of abscess pressure as a most important variable in abscess formation. We conclude that abscess pressure may play a pivotal role in systemic spreading of the primarily localized process.
Bertram
P
P
Chirurgische Universitätsklinik und Poliklinik, RWTH Aachen, Germany.
Treutner
K H
KH
Klosterhalfen
B
B
Arlt
G
G
Anurov
M
M
Polivoda
M
M
Ottinger
A
A
Schumpelick
V
V
D000038:Abscess / Q000503:physiopathology*; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D007375:Interleukin-1 / Q000097:blood; D010865:Pilot Projects; D011312:Pressure; D018805:Sepsis / Q000503:physiopathology; D013290:Streptococcal Infections / Q000503:physiopathology*; D013530:Surgical Wound Infection / Q000503:physiopathology*; D013552:Swine; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha
Artifizielle Drucksteigerung im subkutanen Abszess mit Nachweis einer systemischen Allgemeinreaktion.