Chelating agents as potential antitumorals: alpha-(N)-heterocyclic hydrazones and bis-alpha-(N)-heterocyclic hydrazones.
A number of pyruvic acid and methylpyruvate alpha-(N)-heterocyclic hydrazones has been synthesized. Bis-heterocyclic hydrazones were obtained from reaction with pyruvic carboxaldehyde. Some complexes of Ni(II) were prepared and characterized as neutral complexes. All these compounds have been evaluated for cytotoxicity against P388 and HL-60 leukemia.
Savini
L
L
Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Italy.
Massarelli
P
P
Chiasserini
L
L
Nencini
C
C
Pellerano
C
C
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002614:Chelating Agents; D006835:Hydrazones; D008024:Ligands