title: Radiotherapy for Kimura's disease: the optimum dosage.
abstract: OBJECTIVE
  To evaluate retrospectively the optimum dosage of irradiation for Kimura's disease.
  
  
  METHODS
  Twenty patients with Kimura's disease were treated with radiotherapy. The sex ratio was 19 males to 1 female. The mean ages at onset, initial treatment, and radiotherapy were 26.2, 29.5, and 32.2 years, respectively. Radiotherapy was mainly applied for residual or recurrent tumors. The eosinophil count increased by more than 10% in 18 of the 20 patients. In most instances, irradiation was given through a single field with dosages ranging from 20 to 44 Gy.
  
  
  RESULTS
  At the completion of radiotherapy, a marked response in tumor size was noted in all cases. The minimum follow-up was 48 months. Local control was obtained in 23 of 31 lesions (74.1%). At dosages of < or =25 Gy, 26-30 Gy, and > 30 Gy, local control was obtained in 2 of 8 (25.0%), 9 of 10 (90.0%), and 12 of 13 sites (92.3%), respectively.
  
  
  CONCLUSIONS
  Radiotherapy is an effective treatment for Kimura's disease. This strongly suggests that no surgical procedure other than a biopsy should be carried out. The radiation field should be limited to the lesion and swelling of the adjacent lymph nodes as much as possible, with a optimum dosage of 26-30 Gy regardless of tumor size.
authors.affiliation: Department of Radiology, Sapporo Medical University, School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hareyama
authors.forename: A
authors.initials: A
authors.lastname: Oouchi
authors.forename: H
authors.initials: H
authors.lastname: Nagakura
authors.forename: K
authors.initials: K
authors.lastname: Asakura
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Tamakawa
authors.forename: H
authors.initials: H
authors.lastname: Akiba
authors.forename: K
authors.initials: K
authors.lastname: Sakata
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Koito
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: A
authors.initials: A
authors.lastname: Kataura
authors.forename: K
authors.initials: K
authors.lastname: Morita
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000473:pathology / Q000532:radiotherapy*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012189:Retrospective Studies