title: A pilot study comparing ketoprofen and acetaminophen with hydrocodone for the relief of postoperative periodontal discomfort.
abstract: The aim of this study was to compare ketoprofen to acetaminophen with hydrocodone (A/H) in a postoperative periodontal pain model. A double-blind protocol was used. Thirty minutes prior to each procedure, subjects were given orally either 100 mg ketoprofen or a placebo tablet. Four hours later, the subjects took either 50 mg ketoprofen (ketoprofen group) or 1000 mg acetaminophen with 10 mg hydrocodone (placebo group). Subjects reported levels of overall discomfort and pain using visual analog scales at eight hourly intervals following the first dose of ketoprofen or placebo. Information about adverse side effects was requested from the patients in the form of a checklist. The results revealed only small differences between the two drug regimens with respect to levels of pain or overall discomfort. A/H provided significantly better pain relief at Hours 5 and 6, while overall discomfort levels were significantly higher with ketoprofen than with placebo at Hours 3 and 4. Pain levels were low for both groups. It is recommended that additional analgesics for mild to moderate pain should be tested.
authors.affiliation: Department of Biological Structure and Function, School of Dentistry, Oregon Health Sciences University, Portland, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Reed
authors.forename: J R
authors.initials: JR
authors.lastname: Smith
authors.forename: T
authors.initials: T
authors.lastname: Lie
authors.forename: D F
authors.initials: DF
authors.lastname: Adams
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000766:Anesthesia, Dental; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D006853:Hydrocodone / Q000627:therapeutic use*; D007660:Ketoprofen / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D010166:Palliative Care; D010510:Periodontal Diseases / Q000601:surgery*; D010865:Pilot Projects
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D006853:Hydrocodone; D007660:Ketoprofen