Super potent topical corticosteroid use associated with adrenal suppression: clinical considerations.
The potential for a variety of local and systemic side effects from the use of potent topical corticosteroids has long been recognized. However, adrenal suppression has only rarely been documented. We describe two patients with profound hypothalamic-pituitary-adrenal axis suppression resulting from the unregulated use of super potent topical corticosteroids.
Gilbertson
E O
EO
Department of Medicine, UCSD School of Medicine, San Diego, California, USA.
Spellman
M C
MC
Piacquadio
D J
DJ
Mulford
M I
MI
D000287:Administration, Topical; D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D002908:Chronic Disease; D002990:Clobetasol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D003864:Depression, Chemical; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D009824:Ointments; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy; D012651:Self Medication / Q000009:adverse effects
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D009824:Ointments; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone; D002990:Clobetasol