title: Postoperative accelerated radiotherapy in high-risk squamous cell carcinoma of the head and neck: long-term results of a prospective trial.
abstract: BACKGROUND
  For patients treated with combination resection and postoperative radiotherapy, the interval between surgery and completion of radiotherapy represents an opportunity for tumor repopulation and treatment failure. A prospective trial to test the feasibility and efficacy of accelerated postoperative radiotherapy was concluded in August of 1990.
  
  
  METHODS
  Thirty-two patients with high-risk pathologic findings were treated with 63 Gy in 35 fractions of 1.8 Gy over 5.2 weeks using a modified concomitant-boost technique.
  
  
  RESULTS
  Acute mucosal and skin reactions were increased but tolerable. At a median follow-up of 6 years, the crude in-field recurrence rate for the entire group was 10/32 (31%), with 0/10 (0%) recurrences in patients commencing accelerated radiotherapy within 4 weeks of surgery and 10/22 (45%) recurrences in patients with a delay of more than 4 weeks (p = .006). The rate of late complications appears similar to that seen with conventional radiotherapy, with possibly a higher rate of "consequential"-type late effects.
  
  
  CONCLUSIONS
  This pilot study suggests that prompt application of accelerated postoperative radiotherapy significantly improves local-regional control and supports the concept of rapid tumor repopulation in the postoperative setting. Various strategies to overcome tumor repopulation are discussed.
authors.affiliation: Division of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, James A. Haley Veterans Administration Medical Center at the University of South Florida, Tampa 33612, USA.
authors.forename: A
authors.initials: A
authors.lastname: Trotti
authors.forename: D
authors.initials: D
authors.lastname: Klotch
authors.forename: J
authors.initials: J
authors.lastname: Endicott
authors.forename: M
authors.initials: M
authors.lastname: Ridley
authors.forename: A
authors.initials: A
authors.lastname: Cantor
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D002423:Cause of Death; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005240:Feasibility Studies; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D009061:Mouth Mucosa / Q000528:radiation effects; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control; D009367:Neoplasm Staging; D010865:Pilot Projects; D011182:Postoperative Care; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D012867:Skin / Q000528:radiation effects; D013997:Time Factors; D017211:Treatment Failure