title: The human phase response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to light.
abstract: Melatonin's timekeeping function is undoubtedly related to the fact that it is primarily produced during nighttime darkness; that is, melatonin and light occur at opposite times. The human phase response curve (PRC) to melatonin appears to be about 12h out of phase with the PRC to light. These striking complementarities, together with light's acute suppressant effect on melatonin production, suggest that a function for endogenous melatonin is to augment entrainment of the circadian pacemaker by the light-dark cycle. The melatonin PRC also indicates correct administration times for using exogenous melatonin to treat circadian phase disorders.
authors.affiliation: Department of Psychiatry, Oregon Health Sciences University, Portland 97201-3098, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lewy
authors.forename: V K
authors.initials: VK
authors.lastname: Bauer
authors.forename: S
authors.initials: S
authors.lastname: Ahmed
authors.forename: K H
authors.initials: KH
authors.lastname: Thomas
authors.forename: N L
authors.initials: NL
authors.lastname: Cutler
authors.forename: C M
authors.initials: CM
authors.lastname: Singer
authors.forename: M T
authors.initials: MT
authors.lastname: Moffit
authors.forename: R L
authors.initials: RL
authors.lastname: Sack
mesh_terms: D000328:Adult; D000368:Aged; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D018849:Controlled Clinical Trials as Topic; D003624:Darkness; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000096:biosynthesis / Q000493:pharmacokinetics; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D008550:Melatonin