title: [Effect of thymoleptics in aspects of new clinical systematics of depressive syndrome].
abstract: Analysis of present concepts of clinico-pharmacological correlations in depression shows the necessity of search for new approaches to the problem. The original clinical model of depression, based on the idea of positive and negative affectivity in its structure is discussed. When applied to therapeutical strategy these principals elucidate new clinical signs for choice of appropriate class of antidepressants. The correlation between predominance of positive or negative appearance of depression and efficacy of antidepressants with selective and non-selective neurochemical action is suggested. A new clinical classification of antidepressants based on their influence on the negative or positive appearance of affective disorder is suggested. The speculations on certain neurochemical specificity of negative and positive disorders are presented.
authors.forename: A B
authors.initials: AB
authors.lastname: Smulevich
authors.forename: M A
authors.initials: MA
authors.lastname: Morozova
mesh_terms: D000928:Antidepressive Agents / Q000145:classification / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D012449:Safety; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors
vernacular_title: Effekty timoleptikov v aspekte novoĭ klinicheskoĭ sistematiki depressivnogo sindroma.