title: Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1.
abstract: The human bone morphogenetic protein-1 was originally identified as a protein with the capacity to stimulate bone and cartilage growth in vitro. Its gene sequence identified it as an alternatively spliced human homolog of the Drosophila dorsal-ventral patterning tolloid gene and suggested that it activates transforming growth factor-beta-like molecules by proteolytic cleavage. Its expression pattern and its recently identified activity as a procollagen C proteinase, however, suggest that it has a more general function in the early stages of embryogenesis. This view is strengthened by the previous observation of a third alternatively spliced isoform of the gene, called bone morphogenetic protein 1/His. We now show that the gene is expressed in three additional variants, leading to shorter and slightly modified C-termini. The three variants are preferentially expressed in placenta but show individual differences in their expression profiles in other soft tissues.
authors.affiliation: Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Janitz
authors.forename: V
authors.initials: V
authors.lastname: Heiser
authors.forename: U
authors.initials: U
authors.lastname: Böttcher
authors.forename: O
authors.initials: O
authors.lastname: Landt
authors.forename: R
authors.initials: R
authors.lastname: Lauster
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001483:Base Sequence; D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D008666:Metalloendopeptidases / Q000235:genetics*; D008969:Molecular Sequence Data
chemical_list: D019485:Bone Morphogenetic Proteins; D008666:Metalloendopeptidases; C525705:BMP1 protein, human; D055395:Bone Morphogenetic Protein 1