title: Radiation following chemotherapy for mediastinal Hodgkin's disease: the outcome of various doses for bulky tumors.
abstract: Twenty-one patients with bulky mediastinal disease responding to chemotherapy received consolidation with low-dose mediastinal radiation (19.8-25.2 Gy). Their 5-year mediastinal failure rate (10%) was equivalent to that of 10 similar patients who received higher doses of 30-44 Gy (20%). Low-dose radiation may be appropriate for these patients. Prospective studies are required to verify these findings.
authors.affiliation: Department of Radiation Oncology, University of Michigan, Ann Arbor 48109, USA.
authors.forename: A
authors.initials: A
authors.lastname: Eisbruch
authors.forename: E A
authors.initials: EA
authors.lastname: Kazerooni
authors.forename: W M
authors.initials: WM
authors.lastname: Sahijdak
authors.forename: I R
authors.initials: IR
authors.lastname: Francis
authors.forename: A S
authors.initials: AS
authors.lastname: Lichter
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D018450:Disease Progression; D018572:Disease-Free Survival; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents