title: Atypical central lesions in serpiginous choroiditis treated with oral prednisone.
abstract: OBJECTIVE
  To demonstrate the effect of oral prednisone in the treatment of atypical isolated central lesions in two patients with serpiginous choroiditis.
  
  
  METHODS
  Two patients with a history of serpiginous choroiditis in the fellow eye developed an isolated central lesion. One patient showed combined detachment of the retinal pigment epithelium and serous detachment of the retina, while the other showed thickening of the retinal pigment epithelium and shallow detachment of the retina. Both patients were treated with 80 mg/day of oral prednisone.
  
  
  RESULTS
  In both patients regression of the lesion and improvement of visual acuity was achieved within several days without the development of a chorioretinal scar. In one patient the lesion recurred after discontinuation of the prednisone. With continuation of a low dose of prednisone for several months definite regression of the lesion and improvement of visual acuity to near-normal values was achieved in both patients.
  
  
  CONCLUSIONS
  In two patients with visual loss due to an atypical central lesion in serpiginous choroiditis, regression of the lesion without the development of a typical chorioretinal scar and subsequent improvement of visual acuity was achieved with the administration of oral prednisone.
authors.affiliation: Institute of Ophthalmology, University of Nijmegen, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Hoyng
authors.forename: M
authors.initials: M
authors.lastname: Tilanus
authors.forename: A
authors.initials: A
authors.lastname: Deutman
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002833:Choroiditis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D012163:Retinal Detachment / Q000209:etiology; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D005938:Glucocorticoids; D011241:Prednisone