Complete heart block in association with graft-versus-host disease.
An infant who received haploidentical BM for severe combined immunodeficiency (SCID) developed acute, reversible complete heart block in association with an exacerbation of GVHD. Respiratory distress and myocardial dysfunction were also seen with this and previous GVHD exacerbations. The patient had not received chemotherapy or radiation prior to BMT. The complete heart block resolved after 1 week of intensive immunosuppression. The association of complete heart block with GVHD is important because the heart block is potentially reversible with prompt, aggressive control of the GVHD.
Gilman
A L
AL
Division of Hematology/Oncology, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, USA.
Kooy
N W
NW
Atkins
D L
DL
Ballas
Z
Z
Rumelhart
S
S
Holida
M
M
Lee
N
N
Goldman
F
F
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006086:Graft vs Host Disease / Q000150:complications*; D006327:Heart Block / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D008297:Male
D007166:Immunosuppressive Agents