Secondary ANLL with t(11;19)(q23;p13) following etoposide and cisplatin for ovarian germ cell tumor.
This is a case report of a ten year old girl with ovarian germ cell tumor who was successfully treated with BEP chemotherapy. She developed acute myloid leukemia, AML-M5 with t(11;19)(q23;p13), 29 months after being off therapy. She received a cumulative dose of 2000 mg/m2 of etoposide and 400 mg/m2 of cisplatin. The association of etoposide and therapy related leukemia is reviewed.
Kapoor
G
G
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India.
Kadam
P R
PR
Chougule
A
A
Gladstone
B
B
Advani
S H
SH
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002648:Child; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D002945:Cisplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D018237:Germinoma / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000235:genetics; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D014178:Translocation, Genetic
D005047:Etoposide; D002945:Cisplatin