Influences of 50-Hz magnetic fields and ionizing radiation on c-jun and c-fos oncoproteins.
The effect of magnetic fields (50 Hz, 100 microT[rms] sinusoidal magnetic field combined with a 55 microT geomagnetic-like field) and/or gamma rays of 60 Cobalt on the expression of the c-jun and c-fos proteins was investigated in primary rat tracheal epithelial cells and two related immortalized cell lines. Quite similar patterns and amplitudes of induction of these proteins were evidenced after either ionizing radiation or magnetic field exposure. No synergism after both treatments was observed. These findings suggest that magnetic fields explored in the present study may be considered as an insult at the cellular level.
Lagroye
I
I
CEA/DSV/SRCA/DRR-Laboratoire de Radio Toxicologie, Bruyères-le-Châtel, France.
Poncy
J L
JL
D000818:Animals; D002461:Cell Line, Transformed; D002478:Cells, Cultured; D004574:Electromagnetic Fields; D004847:Epithelial Cells; D005720:Gamma Rays; D015870:Gene Expression / Q000528:radiation effects; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000528:radiation effects*; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014132:Trachea
D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun