The value of methylprednisolone in the treatment of an experimental sensorineural hearing loss following drill-induced ossicular chain injury: a randomized, blinded study in guinea-pigs.
In a previously established animal model a standardized drill-induced injury to the body of the incus was applied, and the effects on hearing were characterized by electrocochleography. In a placebo-controlled, randomized, blinded study methylprednisolone showed no protective effect in reducing or improving the auditory threshold shifts, which occurred within seconds after drilling and remained stable throughout the 5-week observation period. Therefore the otologic surgeon must pay close attention to avoiding any contact of a rotating burr with an ossicle in an intact ossicular chain.
Schneider
W
W
Department of Otorhinolaryngology, University of Erlangen-Nuremberg, Germany.
Gjuric
M
M
Katalinic
A
A
Buhr
W
W
Wolf
S R
SR
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001300:Audiometry, Evoked Response; D001305:Auditory Fatigue / Q000187:drug effects; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology*; D007188:Incus / Q000187:drug effects / Q000293:injuries* / Q000503:physiopathology; D007274:Injections, Intraperitoneal; D007431:Intraoperative Complications / Q000503:physiopathology; D008775:Methylprednisolone / Q000494:pharmacology*; D013525:Surgical Instruments
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone