title: Interaction with a lipid membrane: a key step in bacterial toxins virulence.
abstract: Bacterial toxins are secreted as soluble proteins. However, they have to interact with a cell lipid membrane either to permeabilize the cells (pore forming toxins) or to enter into the cytosol to express their enzymatic activity (translocation toxins). The aim of this review is to suggest that the strategies developed by toxins to insert in a lipid membrane is mediated by their structure. Two categories, which contains both pore forming and translocation toxins, are emerging: alpha helical proteins containing hydrophobic domains and beta sheets proteins in which no hydrophobicity can be clearly detected. The first category would rather interact with the membrane through multi-spanning helical domains whereas the second category would form a beta barrel in the membrane.
authors.affiliation: Université Libre de Bruxelles, Laboratoire de Chimie Physique des Macromolécules aux Interfaces, Belgium. vcabiaux@ulb.ac.be
authors.forename: V
authors.initials: V
authors.lastname: Cabiaux
authors.forename: C
authors.initials: C
authors.lastname: Wolff
authors.forename: J M
authors.initials: JM
authors.lastname: Ruysschaert
mesh_terms: D000595:Amino Acid Sequence; D000942:Antigens, Bacterial; D001427:Bacterial Toxins / Q000737:chemistry* / Q000378:metabolism*; D002462:Cell Membrane / Q000382:microbiology*; D003087:Colicins / Q000737:chemistry / Q000378:metabolism; D004167:Diphtheria Toxin / Q000737:chemistry / Q000378:metabolism; D006460:Hemolysin Proteins / Q000737:chemistry / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D052899:Pore Forming Cytotoxic Proteins; D012995:Solubility; D014774:Virulence
chemical_list: D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D003087:Colicins; D004167:Diphtheria Toxin; D006460:Hemolysin Proteins; D008563:Membrane Lipids; D052899:Pore Forming Cytotoxic Proteins; C030325:anthrax toxin; C021091:staphylococcal alpha-toxin; C032676:aerolysin