Ventricular arrhythmias in adult aortic stenosis: prevalence, mechanisms, and clinical relevance.
With the longer life expectancy of the population, calcific aortic stenosis has become a common cardiac problem in the elderly. When patients with moderate to severe aortic stenosis become symptomatic, the prognosis is usually poor in absence of valve replacement and sudden death is a feared complication. It has been hypothesized that malignant ventricular arrhythmias could be responsible for the high incidence of sudden death in symptomatic patients with aortic stenosis. The purpose of this review is to analyze the prevalence, the electrophysiologic mechanisms, and the possible role of ventricular arrhythmias in the development of symptoms and in the outcome of adult subjects with aortic stenosis.
Sorgato
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A
Divisione di Cardiologia, Ospedale S. Orsola-Fatebenefratelli, Brescia, Italy.
Faggiano
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P
Aurigemma
G P
GP
Rusconi
C
C
Gaasch
W H
WH
D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000150:complications*; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology; D002114:Calcinosis / Q000150:complications*; D016757:Death, Sudden, Cardiac / Q000209:etiology; D004562:Electrocardiography; D005544:Forecasting; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D015994:Incidence; D008017:Life Expectancy; D017063:Outcome Assessment, Health Care; D015995:Prevalence; D011379:Prognosis; D013575:Syncope / Q000150:complications; D018754:Ventricular Dysfunction / Q000209:etiology* / Q000503:physiopathology