title: [High- and low-risk molecular sequences in autoimmune diseases. An analysis of type I diabetes in Latin America].
abstract: Type I diabetes is an autoimmune and a polygenic disease, in which MHC-class II genes contribute to 48% of the disease. The aim of the present study, is to provide a guideline to understanding the molecular association of these genes, through the immunogenetic analysis of 3 Latin american mestizo populations. We included 606 individuals, 349 patients with DMDI and 257 healthy controls coming from 3 geographical areas: Mexico City, Mexico; Caracas, Venezuela and Medellin, Colombia. The results clearly indicate that in mestizo groups, the diabetogenic haplotypes are from mediterranean ancestry, while protection is due to Amerindian genes. It was demonstrated that the relevant sequences for IDDM expression are located to DRB1 and DQB1 loci with a minimal contribution of DQA1 residues. The sequences determining peptide recognition and the induction of TH1 cells mediating the cellular autoimmune response are in positions DRB1-57 and 74 (an aspartic acid and a glutamic acid respectively, confer protection), modulated by D-57 in the DQ, 8 chain. These data show that DRB1-DQB1 haplotypes are central for IDDM expression and open new pathways for the disease management.
authors.affiliation: Departamento de Inmunogenética, INDRE, SSA, MEXICO D.F. cgorodeaUmailer.main.conacyt.mx
authors.forename: C
authors.initials: C
authors.lastname: Gorodezky
authors.forename: A
authors.initials: A
authors.lastname: Olivo
authors.forename: C
authors.initials: C
authors.lastname: Alaez
authors.forename: M N
authors.initials: MN
authors.lastname: Vázquez
authors.forename: G
authors.initials: G
authors.lastname: de la Rosa
authors.forename: H
authors.initials: H
authors.lastname: Debaz
authors.forename: C
authors.initials: C
authors.lastname: Robles
authors.forename: N
authors.initials: N
authors.lastname: Altamirano
authors.forename: Z
authors.initials: Z
authors.lastname: Layrisse
authors.forename: P L
authors.initials: PL
authors.lastname: Balducci
authors.forename: E
authors.initials: E
authors.lastname: Domínguez
authors.forename: F
authors.initials: F
authors.lastname: Herrera
authors.forename: S
authors.initials: S
authors.lastname: Montagnani
authors.forename: B
authors.initials: B
authors.lastname: Esparza
authors.forename: O
authors.initials: O
authors.lastname: Balbas
authors.forename: P
authors.initials: P
authors.lastname: Gunczler
authors.forename: R
authors.initials: R
authors.lastname: Lanes
authors.forename: R
authors.initials: R
authors.lastname: Amaro
authors.forename: R
authors.initials: R
authors.lastname: Zaro
authors.forename: V
authors.initials: V
authors.lastname: Fuenmayor
authors.forename: F
authors.initials: F
authors.lastname: Montoya
authors.forename: C I
authors.initials: CI
authors.lastname: Bedoya
authors.forename: M C
authors.initials: MC
authors.lastname: Restrepo
authors.forename: A
authors.initials: A
authors.lastname: Villegas
authors.forename: J L
authors.initials: JL
authors.lastname: Vicario
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001208:Asia / Q000208:ethnology; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003105:Colombia / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics; D004198:Disease Susceptibility; D005006:Ethnicity / Q000235:genetics; D005060:Europe / Q000208:ethnology; D005260:Female; D005802:Genes, MHC Class II; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D007198:Indians, North American; D007199:Indians, South American; D007223:Infant; D007843:Latin America / Q000453:epidemiology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012307:Risk Factors; D014687:Venezuela / Q000453:epidemiology; D044465:White People
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains
vernacular_title: Secuencias moleculares de alto y bajo riesgo en enfermedades autoinmunes. Un análisis de la diabetes tipo I en Latinoamérica.