title: t(3;17)(q21;q25) in Epstein-Barr virus associated peripheral T-cell lymphoma: a paediatric case.
abstract: We describe an immunocompetent 8-year-old boy with a serological profile indicating chronic infection by Epstein-Barr virus (EBV) who developed subcutaneous and pulmonary lesions related to a peripheral T-cell proliferation. No clonal rearrangement of T-cell receptor or immunoglobulin genes was seen. However, the finding of a t(3;17)(q21;q25) in 44 metaphases from one skin lesion demonstrated a clonal origin. We also showed that the proliferative T cells contained EBV genome leading to the diagnosis of EBV-associated peripheral T-cell lymphoma. Further cytogenetic and molecular studies are needed to identify genes implicated in the pathogenesis of this haematological malignancy.
authors.affiliation: Department of Clinical Haematology, Hospital Jean Bernard, Poitiers, France.
authors.forename: F
authors.initials: F
authors.lastname: Millot
authors.forename: F
authors.initials: F
authors.lastname: Brizard
authors.forename: P
authors.initials: P
authors.lastname: Babin
authors.forename: D
authors.initials: D
authors.lastname: Canioni
authors.forename: E
authors.initials: E
authors.lastname: Macintyre
authors.forename: G
authors.initials: G
authors.lastname: Levard
authors.forename: C
authors.initials: C
authors.lastname: Gambert
authors.forename: C
authors.initials: C
authors.lastname: Ricour
authors.forename: F
authors.initials: F
authors.lastname: Guilhot
mesh_terms: D002648:Child; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D004854:Herpesvirus 4, Human; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics* / Q000821:virology; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics* / Q000821:virology; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics* / Q000821:virology; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics* / Q000821:virology; D014178:Translocation, Genetic; D014412:Tumor Virus Infections / Q000235:genetics*