Independent regulation of anterior/posterior and equatorial/polar polarity in the Drosophila eye; evidence for the involvement of Wnt signaling in the equatorial/polar axis.
The Drosophila retina is made from hundreds of asymmetric subunit ommatidia arranged in a crystalline-like array with each unit shaped and oriented in a precise way. One explanation for the precise cellular arrangements and orientations of the ommatidia is that they respond to two axes of polarized information present in the plane of the retinal epithelium. Earlier work showed that one of these axes lies in the anterior/posterior(A/P) direction and that the polarizing influence is closely associated with the sweep of the Hedgehog-dependent morphogenetic wave. Here we present evidence for a second and orthogonal axis of polarity, and show that it can be functionally separated from the A/P axis. Further, we show that the polarizing information acting in this equatorial/polar axis (Eq/Pl) is established in at least two steps - the activity of one signaling molecule functions to establish the graded activity of a second signal.
Wehrli
M
M
Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Tomlinson
A
A
D000818:Animals; D019521:Body Patterning; D016764:Cell Polarity / Q000502:physiology*; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins; D005260:Female; D017344:Genes, Insect; D005838:Genotype; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D009024:Morphogenesis; D009030:Mosaicism; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012160:Retina / Q000166:cytology* / Q000502:physiology*; D015398:Signal Transduction; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D019476:Insect Proteins; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C074622:wg protein, Drosophila