title: Familial resemblance for resting blood pressure with particular reference to racial differences: preliminary analyses from the HERITAGE Family Study.
abstract: Resting blood pressure in both white and black families participating in the HERITAGE Family Study was analyzed using a simple familial correlation model to assess familial influences. The two samples of black and white families were analyzed separately and together, providing an opportunity to test for heterogeneity in the familial resemblance. Maximal heritability was 46% for systolic blood pressure (SBP) and 31% for diastolic blood pressure (DBP) in the pooled sample. Noticeably higher heritabilities were found in the black sample (68% for SBP and 56% for DBP) than in the white sample (43% for SBP and 24% for DBP). The patterns of familial correlations were similar in blacks and whites, with the exception that spouse resemblance was significant in white families but not in black families. These results along with the finding that the magnitude of the familial correlations was higher in the black sample than in the white sample suggest that the effects of host and familial environmental factors differ between the races.
authors.affiliation: Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: C
authors.initials: C
authors.lastname: Gu
authors.forename: I
authors.initials: I
authors.lastname: Borecki
authors.forename: J
authors.initials: J
authors.lastname: Gagnon
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
authors.forename: A S
authors.initials: AS
authors.lastname: Leon
authors.forename: J S
authors.initials: JS
authors.lastname: Skinner
authors.forename: J H
authors.initials: JH
authors.lastname: Wilmore
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
mesh_terms: D000293:Adolescent; D000328:Adult; D044383:Black People / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D005260:Female; D018740:Genetic Heterogeneity; D005828:Genetics, Population; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics*; D001741:Black or African American