Red cell aplasia in children on tacrolimus after liver transplantation.
Hematological toxicity of tacrolimus has been rarely reported. We report two pediatric recipients of liver transplantation with anemia. They were treated with tacrolimus for 8 and 47 months, respectively, before developing pure red cell aplasia (PRCA) confirmed by bone marrow biopsy. The children recovered quickly on withdrawal of tacrolimus. The clinical profile of these children is compared with the only other patient reported in the literature with PRCA due to tacrolimus. All three patients had similar hematological findings. However, the mechanism of the tacrolimus-induced PRCA in these children appears to be different from that reported in the adult patient.
Misra
S
S
Department of Pediatrics, UCLA Medical Center, Los Angeles, California 90095-1752, USA.
Moore
T B
TB
Ament
M E
ME
Busuttil
R W
RW
McDiarmid
S V
SV
D000328:Adult; D001803:Blood Transfusion; D001853:Bone Marrow / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007223:Infant; D016031:Liver Transplantation / Q000276:immunology*; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D016559:Tacrolimus / Q000009:adverse effects*; D013997:Time Factors
D007166:Immunosuppressive Agents; D016559:Tacrolimus