Endoscopic and pathological manifestations of the gastrointestinal tract in familial amyloidotic polyneuropathy type I (Met30).
OBJECTIVE
To evaluate the characteristic changes in the gastrointestinal tract in familial amyloidotic polyneuropathy (FAP) (Met30), both fibre gastroscopy and colonoscopy studies were performed in FAP (Met30) patients. Microscopic changes were also examined in autopsied and biopsied materials from patients with FAP, and compared with data from autopsied samples from patients with AL amyloidosis, and secondary amyloidosis patients.


METHODS
Endoscopic and histopathological study.


METHODS
Kumamoto University Hospital, Kumamoto, Japan.


METHODS
Nine patients with FAP (Met30) underwent fibre gastroscopy and colonoscopy. Six autopsied and 23 biopsied gastrointestinal samples from FAP patients, four from autopsied amyloidosis (including two myeloma associated form), and two from autopsied secondary amyloidosis patients were examined for histopathological study.


METHODS
Fibre gastroscopy and colonoscopy were employed for macroscopic study. Congo red and H-E staining were performed for histopathological study. Macroscopic changes in the gastrointestinal tract and microscopic differences in the amyloid distribution pattern were compared between the different types of amyloidosis.


RESULTS
Fibre gastroscopy and colonoscopy for nine FAP patients revealed that four showed a fine granular appearance in the duodenum, three showed lack of lustre, and two showed mucosal friability in the gastrointestinal tract; however, no macroscopic abnormality was observed in four other FAP patients. Histopathological examination of tissue from FAP patients revealed that, although a small amount of amyloid was recognized in the submucosa perivascular layer, a significant amount of amyloid was seen in and around the nerves of the gastrointestinal tract, but very little in Auerbach's nerve plexus. In total, the amount of deposited amyloid in the tissues was small compared with that in other types of systemic amyloidosis, such as AL and secondary amyloidosis.


CONCLUSIONS
These results suggest that the major reason why FAP patients show such severe gastrointestinal symptoms, compared with other types of systemic amyloidosis, may be because of the deposition of a significant amount of amyloid in the nerves in the gastrointestinal tract.
Yoshimatsu
S
S
First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Ando
Y
Y
Terazaki
H
H
Sakashita
N
N
Tada
S
S
Yamashita
T
T
Suga
M
M
Uchino
M
M
Ando
M
M
D000328:Adult; D000682:Amyloid / Q000032:analysis; D017772:Amyloid Neuropathies / Q000235:genetics / Q000473:pathology*; D001344:Autopsy; D001706:Biopsy; D003113:Colonoscopy; D004064:Digestive System / Q000473:pathology*; D004947:Esophagus / Q000473:pathology; D005260:Female; D005773:Gastroscopy; D006801:Humans; D007422:Intestines / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D013270:Stomach / Q000473:pathology
D000682:Amyloid