The antagonism of ipsapirone induced biobehavioral responses by +/- pindolol in high and low impulsives.
The present study was conducted to investigate whether +/- pindolol antagonizes ipsapirone induced biobehavioral changes in a personality dependent way. Our previous work demonstrated that high impulsives show higher immune cell responses than low impulsive subjects upon treatment with ipsapirone. A total number of 80 healthy male volunteers received placebo (N = 20) or 10 mg ipsapirone (N = 20), 30 mg +/- pindolol (N = 20), or a combination of 30 mg +/- pindolol and 10 mg ipsapirone (N = 20). Each group consisted of 10 low and 10 high impulsive subjects. Since 5-HT related drugs induce thermoregulatory responses, the study took place in a climate chamber with a constant ambient temperature. Blood samples (for measurement of CD4+ cell counts) were drawn from an indwelling catheter invisibly for the subjects. The results clearly demonstrate that the ipsapirone induced decreases in body temperature and number of peripheral CD4+ cells are more pronounced in high impulsives. +/- Pindolol antagonizes thermoregulatory and CD4+ cell responses. The results are discussed with respect to mechanisms of alteration in 5-HT function related to impulsivity.
Hennig
J
J
Department of Psychology, University of Giessen, Federal Republic of Germany.
Opper
C
C
Huwe
S
S
Netter
P
P
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001831:Body Temperature / Q000187:drug effects; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D006801:Humans; D007175:Impulsive Behavior; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000187:drug effects; D010556:Personality Tests; D010869:Pindolol / Q000494:pharmacology*; D011743:Pyrimidines / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; C043077:ipsapirone; D010869:Pindolol