Local antifibrinolytic treatment with tranexamic acid in hemophilic children undergoing dental extractions.
The incidence of post-extraction bleeding and the amount of replacement therapy needed to control bleeding in 24 hemophilic children following the local use of tranexamic acid mouthwash have been investigated. The results of the study showed that 91.6% of patients who used tranexamic acid mouthwash as a supplement to systemic therapy, did not develop post-extraction bleeding; while in 25% of the control patients who received only systemic tranexamic acid, postoperative bleeding was not observed.
Waly
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NG
Pedodontic Dept., Faculty of Oral and Dental Medicine, Cairo University.
D000284:Administration, Oral; D000287:Administration, Topical; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000008:administration & dosage; D005340:Fibrinogen / Q000008:administration & dosage; D005884:Gingival Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D007262:Infusions, Intravenous; D009067:Mouthwashes; D014081:Tooth Extraction / Q000009:adverse effects*; D014148:Tranexamic Acid / Q000008:administration & dosage*
D000933:Antifibrinolytic Agents; D009067:Mouthwashes; C026912:cryoprecipitate coagulum; D014148:Tranexamic Acid; D005169:Factor VIII; D005340:Fibrinogen