Soluble adhesion molecules in type 1 diabetes mellitus.
Adhesion molecules play an important role during leukocyte emgration from blood vessels. Furthermore, adhesion molecules are involved in the regulation of the immune system. In addition to membrane-bound adhesion molecules soluble forms have been detected in human serum. During the last few years we have analysed the role of adhesion molecules during the pathogenesis of type 1 diabetes. This review describes the results of studies on membrane-bound and soluble adhesion molecules in humans and the model of the NOD mouse. Based on these results different adhesion molecule-specific immunotherapies are presented for the prevention of type 1 diabetes and its preclinical stages.
Martin
S
S
Diabetes Research Institute, Heinrich-Heine Universität of Düsseldorf, Germany.
D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000627:therapeutic use; D008213:Lymphocyte Activation; D051379:Mice; D016688:Mice, Inbred NOD; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology
D015815:Cell Adhesion Molecules; D011993:Recombinant Fusion Proteins; D018799:Intercellular Adhesion Molecule-1