Tumor differentiation-dependent local immunity in human head and neck cancers.
Distribution of markers of local cell-mediated immunity was examined in oral tumors exhibiting different histological stages of differentiation. Using a RT-PCR-based semiquantitative technique we determined levels of Langerhans cells, CD4- and CD8-positive T-cells, macrophages/NK cells, beta2-microglobulin and IFN-gamma mRNAs from tissue biopsies. A positive correlation was found between levels of these immunological markers and the tumor differentiation stage. Since tumor differentiation may correlate with the prognosis and response to various treatment modalities, our results may be useful clinically.
Arany
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I
Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston 77555, USA.
Adler-Storthz
K
K
Chen
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Z
Tyring
S K
SK
Brysk
M M
MM
D018949:Antigens, CD1 / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000378:metabolism; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D017452:Receptors, IgG / Q000032:analysis; D014158:Transcription, Genetic; D001613:beta 2-Microglobulin / Q000378:metabolism
D018949:Antigens, CD1; D015415:Biomarkers; D015704:CD4 Antigens; D016827:CD8 Antigens; D012333:RNA, Messenger; D017452:Receptors, IgG; D001613:beta 2-Microglobulin; D007371:Interferon-gamma