Zinc intestinal absorption in newborn rats at 21 day postpartum: effects of maternal ethanol consumption.
This study was designed to examine the effects of prenatal and postnatal exposure of ethanol in the in vivo absorption of zinc in the small intestine in newborn rats at the 21st day after birth. The rats were accustomed to increasing amounts of ethanol (5 to 20%, vol/vol) in tap water for 1 month. During pregnancy and suckling period, ethanol-fed dams were assigned again to ethanol 20% in drinking water. Two sets of experiments were performed. In the first set, jejunal zinc absorption in control group and litters nursed by dams receiving ethanol showed a gradual increase along with the increase of perfusion time at all the assayed concentrations. In general, in litters of ethanol-fed dams, jejunal zinc absorption expressed as nmol/intestinal surface was higher than in control animals. In the second set of experiments, distal ileum zinc absorption in offspring of ethanol-fed dams showed a significantly decrease at all concentrations tested. The results showed that intestinal parameters measured in jejunum and distal ileum of litters exposed to ethanol were always significantly less than in control newborn. These results indicate that exposure of rats to ethanol during the pregnancy and suckling period, may affect postnatal development of intestinal functions and decrease the distal ileum zinc absorption in pups at the end of the lactation period.
Tavares
E
E
Departamento de Fisiología y Biología Animal, Facultad de Farmacia, Universidad de Sevilla, Spain.
Carreras
O
O
Gómez-Tubio
A
A
Herce-Pagliali
C
C
Murillo
M L
ML
D000818:Animals; D000831:Animals, Newborn; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D051381:Rats; D013054:Spectrophotometry, Atomic; D015032:Zinc / Q000097:blood / Q000493:pharmacokinetics*
D000431:Ethanol; D015032:Zinc