title: Evolution of grass-cutter (Thryonomys swinderianus) inflammation markers: comparison with rabbit (Oryctolagus cuniculus) and rat (Rattus norvegicus).
abstract: An inflammatory reaction was induced in grass-cutters (Thryonomys swinderianus) by injecting turpentine. The changes in the plasma haptoglobin, fibrinogen, alpha 2 macroglobulin and immunoglobulin G was followed for 23 days by immunonephelometry. The results were compared to rat and rabbit. They showed that (a) the inflammatory reaction is delayed in the grass-cutter compared to rats and rabbits; (b) the concentration of haptoglobin increases less than in rat and rabbit; (c) the fibrinogen concentration is very low in the grass-cutter, despite hypercoagulability of blood; (d) the changes in the plasma alpha 2-macroglobulin in the grass-cutter seems to be comparable to that of rabbit alpha 1 macroglobulin in amplitude and in its slow return to the initial concentration; and (e) fibrinogen and haptoglobin are suitable markers for grass-cutter inflammation monitoring.
authors.affiliation: Laboratoire de Biochimie FAST/UNB, Cotonou, République du Benin.
authors.forename: H
authors.initials: H
authors.lastname: Ahissou
authors.forename: T
authors.initials: T
authors.lastname: Lebreton de Vonne
authors.forename: F
authors.initials: F
authors.lastname: Esnard
authors.forename: H
authors.initials: H
authors.lastname: Mouray
mesh_terms: D000818:Animals; D005075:Biological Evolution; D015415:Biomarkers; D004591:Electrophoresis, Polyacrylamide Gel; D005340:Fibrinogen / Q000378:metabolism; D006242:Haptoglobins / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits; D051381:Rats; D012377:Rodentia / Q000502:physiology*; D013997:Time Factors; D014425:Turpentine; D000511:alpha-Macroglobulins / Q000378:metabolism
chemical_list: D015415:Biomarkers; D006242:Haptoglobins; D000511:alpha-Macroglobulins; D005340:Fibrinogen; D014425:Turpentine