[Treatment of patients with chronic pulmonary tuberculosis with expectoration--evaluation of effectiveness].
48 patients with chronic pulmonary tuberculosis (10 women and 38 men) aged between 22 and 87 years were treated. They were sputum culture positive from 1 to 12 years (x = 3.6). In chronics all patients but one were resistant to one or more drugs (average to 4 drugs). Control group consisted of 29 patients with recently diagnosed pulmonary tuberculosis sensitive to all drugs. Treatment of chronics based on: selection of drugs according to susceptibility test, using of 4-6 antituberculous drugs, treatment for not less than one year after sputum culture conversion. Control group was treated with standard therapy consisted of 3 or 4 drugs. Out of 48 chronics 13 patients dropped out due to: drug toxicity in 5 cases, noncompliance in 5 cases and death in 3 cases (in 2nd and 5th months of treatment). Of remaining 35 chronics sputum conversion was achieved in 30 cases (85.7%) average after 9 weeks. In control group 3 patients died during 2 weeks of treatment and remaining patients became sputum culture negative after average 6 weeks. Difference is significant (p = 0.006).
Michałowska-Mitczuk
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I Kliniki Gruźlicy i Chorób Płuc, Instytutu Gruźlicy i Chorób Płuc w Warszawie.
Kuś
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J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010349:Patient Compliance; D013183:Sputum / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology
D000995:Antitubercular Agents
Leczenie chorych na gruźlice płuc przewlekle pratkujacych--ocena skuteczności.