title: Clinical evaluation of sodium fluoride chewable tablets in dental caries.
abstract: Chewable tablets containing low dosage fluoride content were prepared using two varieties of celluloses and their in vitro parameters were evaluated. An eighteen month clinical trial revealed that both these formulations were effective in controlling the caries. However, ethyl cellulose is proved to be superior to methylcellulose as a controlled release matrix material in controlling caries. Thus this study recommends ethylcellulose matrix tablets containing low fluoride content is an efficacious and cost effective drug device in controlling dental caries.
authors.affiliation: College of Pharmaceutical Sciences, Manipal Academy of Higher Education, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Aithal
authors.forename: D N
authors.initials: DN
authors.lastname: Udupa
authors.forename: S
authors.initials: S
authors.lastname: Tandon
mesh_terms: D000284:Administration, Oral; D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D002648:Child; D004245:DMF Index; D003692:Delayed-Action Preparations; D003731:Dental Caries / Q000188:drug therapy*; D005260:Female; D005460:Fluorides, Topical / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008747:Methylcellulose / Q000627:therapeutic use; D010592:Pharmaceutic Aids / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000008:administration & dosage*; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D005460:Fluorides, Topical; D010592:Pharmaceutic Aids; D013607:Tablets; C013517:ethyl cellulose; D012969:Sodium Fluoride; D002482:Cellulose; D008747:Methylcellulose