[Effects of xenotransplantation of pancreatic islet cells on immunological state of patients with diabetic angiopathies].
The cell and humoral immunity state was studied up in 35 patients with diabetic angiopathy (insulin-dependent diabetes mellitus) before and 7 days, 3, 6, 9 and 12 months after the pancreatic islet cells (PIC) xenotransplantation conduction in newborn piglets. Stimulation or suppression of the recipient immune system were not observed. This is associated with the PIC immune modulation due to their cultivation. Transplantation of the newborn piglets PIC is a safe method concerning the recipient immune system state. The contents of antibodies to insulin do not change in term of observation up to one year after the PIC cultures xenotransplantation conduction.
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D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000601:surgery*; D003925:Diabetic Angiopathies / Q000276:immunology* / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007330:Insulin Antibodies / Q000032:analysis; D016381:Islets of Langerhans Transplantation; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014183:Transplantation, Heterologous
D007136:Immunoglobulins; D007330:Insulin Antibodies
Vplyv ksenotransplantatsiï klityn pankreatychnykh ostrivtsiv na imunolohichnyĭ status khvorykh z diabetychnoiu anhiopatiieiu.