title: MRI follow-up in a case of clinically diagnosed Creutzfeld-Jakob disease.
abstract: We report the case of a 75-year-old woman suffering from Creutzfeld-Jakob disease (CJD). As brain biopsy was refused, diagnosis had to be based on clinical examination, EEC and findings on cranial MRI. Over a 4-month period MRI examinations demonstrated progressive cortical atrophy and bilateral enhanced signal intensity on T2-weighted images of caudate nuclei and putamina indicating development of spongioform degeneration. As clinical course and the characteristic pattern of brain lesions corresponded to cases of neuropathologically confirmed CJD, we suggest that MRI should be considered a valuable diagnostic tool in clinical diagnosis of the disease.
authors.affiliation: Department of Radiology, Christian-Albrechts-Universität zu Kiel, Arnold Heller Strasse 9, D-24105 Kiel, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Hutzelmann
authors.forename: J
authors.initials: J
authors.lastname: Biederer
mesh_terms: D000368:Aged; D001284:Atrophy; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology; D001706:Biopsy; D001921:Brain / Q000473:pathology*; D002421:Caudate Nucleus / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D003704:Dementia / Q000503:physiopathology; D018450:Disease Progression; D004569:Electroencephalography; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D011699:Putamen / Q000473:pathology; D013035:Spasm / Q000503:physiopathology