[The effect of the lectin from Sambucus nigra inflorescences on spontaneous and alkylating agent-induced mutagenesis in mammalian somatic cells].
Data on separation of purified galactose-specific lectin as well as its two polypeptide chains from inflorescences of European elder Sambucus nigra are represented. Their molecule quaternary structure after the pattern a2 b2 is suggested. It was shown that purified protein in concentration 2.0 mg/ml had mutagenic activity and might enhance mutagenic effect of alkylating substance MNNG. Thus, preparations of lectin from inflorescences of European elder influenced on spontaneous and induced by the alkylating agent mutagenicity in mammalian somatic cells in vitro.
Lukash
L L
LL
Karpova
I S
IS
Miroshnichenko
O S
OS
Tikhonova
T N
TN
Lylo
V V
VV
Man'ko
V G
VG
Sukhorada
E M
EM
Golynskaia
E L
EL
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003470:Culture Media; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D037102:Lectins / Q000302:isolation & purification / Q000494:pharmacology*; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D016296:Mutagenesis / Q000187:drug effects*; D009153:Mutagens / Q000494:pharmacology*; D037121:Plant Lectins; D054788:Ribosome Inactivating Proteins
D000477:Alkylating Agents; D003470:Culture Media; D037102:Lectins; D009153:Mutagens; D037121:Plant Lectins; C050600:Sambucus nigra lectins; D008769:Methylnitronitrosoguanidine; D054788:Ribosome Inactivating Proteins
Vliianie lektina sotsvetiĭ Sambucus nigra na spontannyĭ i indutisrovannyĭ alkiliruiushchim agentom mutagenez v somaticheskikh kletkakh mlekopitaiushchikh.