title: Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice.
abstract: The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven-transmembrane G protein-coupled receptors that mediate diverse biological responses including secretion, neuromodulation, chemotaxis, and growth. The X chromosome-linked GRP-R gene is expressed widely during embryonic development and predominantly in gastrointestinal, neuronal, and neuroendocrine systems in the adult. Surprisingly, gene-targeted mice lacking a functional GRP-R gene develop and reproduce normally and show no gross phenotypic abnormalities. However, peripheral administration of bombesin at dosages up to 32 nmol/kg to such mice had no effect on the suppression of glucose intake, whereas normal mice showed a dose-dependent suppression of glucose intake. These data suggest that selective agonists for the GRP-R may be useful in inducing satiety.
authors.affiliation: Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.
authors.forename: L L
authors.initials: LL
authors.lastname: Hampton
authors.forename: E E
authors.initials: EE
authors.lastname: Ladenheim
authors.forename: M
authors.initials: M
authors.lastname: Akeson
authors.forename: J M
authors.initials: JM
authors.lastname: Way
authors.forename: H C
authors.initials: HC
authors.lastname: Weber
authors.forename: V E
authors.initials: VE
authors.lastname: Sutliff
authors.forename: R T
authors.initials: RT
authors.lastname: Jensen
authors.forename: L J
authors.initials: LJ
authors.lastname: Wine
authors.forename: H
authors.initials: H
authors.lastname: Arnheiter
authors.forename: J F
authors.initials: JF
authors.lastname: Battey
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D051379:Mice; D008817:Mice, Mutant Strains; D010179:Pancreas / Q000187:drug effects; D018004:Receptors, Bombesin / Q000819:agonists / Q000172:deficiency* / Q000235:genetics; D012527:Satiation / Q000502:physiology*; D012844:Sincalide / Q000494:pharmacology
chemical_list: D018004:Receptors, Bombesin; D002217:Carbachol; D000681:Amylases; D012844:Sincalide; D001839:Bombesin