[Side effects of anticonvulsants in the treatment of idiopathic generalized epilepsy].
This investigation was ainced on detection of frequency and main features of side effects of anticonvulsants in therapy of idiopathic generalized epilepsy. There were observed 190 patients aged 5-29 years suffering from different forms of idiopathic generalized epilepsy. Side effects were revealed in 48.4% of patients as a result of the investigation. Almost half of patients (49.0%) who were administered valproic acid developed side effects. Neuroendocrine dysfunctions and digestive disturbances were the most frequent. Side effects were revealed within the first two months after administration of valproats. Only in 13.2% of cases the treatment and to be stopped at the expense of severeness of side effects. Barbiturates caused side effects in 39.6% of cases. Toxic damage of CNS was the most significant. Hyperkinetic syndrome with lack of attention was observed 37.9% of cases. Succinimides caused side effects in 37.9% of cases. Toxic damage of CNS was the most frequent--in 22.4% of cases, digestive disturbances was in 15.5% of cases. There are no really effective means for correction of above mentioned side effects.
Mukhin
K Iu
KIu
Petrukhin
A S
AS
Rykova
E A
EA
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001463:Barbiturates / Q000009:adverse effects; D002490:Central Nervous System / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004064:Digestive System / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects; D004829:Epilepsy, Generalized / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D012189:Retrospective Studies; D013388:Succinimides / Q000009:adverse effects; D013921:Thrombocytopenia / Q000139:chemically induced*; D014635:Valproic Acid / Q000009:adverse effects
D000927:Anticonvulsants; D001463:Barbiturates; D013388:Succinimides; D014635:Valproic Acid
Pobochnye éffekty antikonvul'santov pri lechenii idiopaticheskoĭ generalizovannoĭ épilepsii.