Failure to find the alpha-synuclein gene missense mutation (G209A) in 100 patients with younger onset Parkinson's disease.
The missense G209A mutation at exon 4 of the alpha-synuclein gene was recently found to be responsible for familial Parkinson's disease (PD) in a large kindred of Italian descent. We studied 100 typical PD patients with onset before age 51, both with and without a family history of PD. We did not find this alpha-synuclein missense mutation in any patient, but it was present in a symptomatic member of the Contursi family.
Chan
P
P
Parkinson's Institute, Sunnyvale, CA 94089, USA.
Tanner
C M
CM
Jiang
X
X
Langston
J W
JW
D000328:Adult; D017668:Age of Onset; D001426:Bacterial Proteins; D005091:Exons; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009679:Nuclear Family; D010300:Parkinson Disease / Q000235:genetics* / Q000503:physiopathology; D017354:Point Mutation; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific); D051843:Synucleins; D051844:alpha-Synuclein
D001426:Bacterial Proteins; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein; C109784:Tsp45I methylase, Thermus sp. YS45; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)