Epilepsy genetics: an abundance of riches for biologists.
Twenty-five genes have been identified in which mutations cause epileptic seizures in mice. The gene for a Na+/H+ exchanger has recently been found to underlie the spontaneous mutant slow wave epilepsy. Studies of such mutants should help elucidate the mechanisms that control neuronal excitability.
McNamara
J O
JO
Department of Medicine, Duke University Medical Center, 401 Bryan Research Building, Research Drive, Durham, North Carolina 27710, USA.
Puranam
R S
RS
D000818:Animals; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics / Q000502:physiology
D017923:Sodium-Hydrogen Exchangers; C069139:growth factor-activatable Na-H exchanger NHE-1