title: In situ detection of Epstein-Barr virus in breast cancer.
abstract: Epstein-Barr virus (EBV) is strongly associated with nasopharyngeal carcinoma and some lymphoepithelioma-like carcinomas from other anatomic sites. This study investigates the presence of EBV in breast cancer. Immunohistochemistry for EBV proteins (EBV nuclear antigen-2 and latent membrane protein-1) and in situ hybridization for EBV-encoded small nuclear RNAs (EBER-1 and -2) were performed in 60 invasive breast cancers. None of the 60 breast cancer samples showed detectable EBV. These results suggest that EBV may not play a significant role in the etiology of breast cancers in Taiwan.
authors.affiliation: Department of Pathology, College of Medicine, National Taiwan University, Taipei.
authors.forename: J S
authors.initials: JS
authors.lastname: Chu
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: K J
authors.initials: KJ
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry / Q000821:virology*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis*; D005260:Female; D006566:Herpesviridae Infections / Q000378:metabolism* / Q000821:virology; D004854:Herpesvirus 4, Human; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008875:Middle Aged; D012342:RNA, Small Nuclear / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D014412:Tumor Virus Infections / Q000378:metabolism* / Q000821:virology; D014763:Viral Matrix Proteins / Q000032:analysis*
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; D012342:RNA, Small Nuclear; D012367:RNA, Viral; D014763:Viral Matrix Proteins