Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity.
A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was only active against Aspergillus niger, but not active against other fungi including yeasts as well as other filamentous like fungi and bacteria. Brasilinolide A exerted an immunosuppressive activity in the assay system of a mixed lymphocyte reaction (MLR).
Tanaka
Y
Y
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Komaki
H
H
Yazawa
K
K
Mikami
Y
Y
Nemoto
A
A
Tojyo
T
T
Kadowaki
K
K
Shigemori
H
H
Kobayashi
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D003470:Culture Media; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009615:Nocardia / Q000737:chemistry* / Q000145:classification
D000900:Anti-Bacterial Agents; D003470:Culture Media; D018942:Macrolides; C111141:brasilinolide A