[Outcome of nephrogenic metaplasia of the bladder in kidney transplant recipients].
OBJECTIVE
To evaluate the risk of recurrence and malignant degeneration of vesical nephrogenic metaplasia in renal transplant recipients.


METHODS
Fourteen patients with known nephrogenic metaplasia were systematically followed. Vesical biopsies were performed with a resector, stained with eosin haemalun saffron, analysed and compared to initial results. Labelling by anti-EBV and anti-CMV monoclonal antibodies was performed in 5 cases of intense inflammatory reactions.


RESULTS
All patients were males, with a median age of 39 years. Nephrogenic metaplasia had been diagnosed 7 to 80 months after renal transplantation (median = 37.8). Twelve patients were reviewed 5 to 116 months after the initial diagnosis (median = 52). Relapse was observed in 83% of cases, but without any malignant degeneration.


CONCLUSIONS
Nephrogenic metaplasia is therefore a benign recurrent disease. The importance of the initial blood supply and fibrosis in the case of recurrence suggest a disorder of the blood supply, probably traumatic in origin. Only symptomatic patients are currently followed.
Karam
G
G
Clinique Urologique, CHU Hôtel-Dieu, Nantes, France.
Gaschignard
N
N
Hourmant
M
M
Prunet
D
D
Garcia
S
S
Le Normand
L
L
Buzelin
F
F
Glémain
P
P
Buzelin
J M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors; D001743:Urinary Bladder / Q000473:pathology*
Devenir de la métaplasie néphrogène vésicale chez les transplantés rénaux.