Cytoskeletal proteins and Golgi dynamics.
Association of the Golgi complex with cytoskeletal elements, in particular microtubules, is required for maintenance of the Golgi's characteristic spatial location within cells and for efficient delivery of proteins and lipids to diverse cellular sites. Recent work has suggested the mechanisms underlying this association involve components, such as ankyrin and spectrin, that facilitate Golgi membrane association with motor proteins, including cytoplasmic dynein, kinesin and myosin. Understanding how these associations are regulated and what roles they play in Golgi trafficking and dynamics is fundamental for insight into the spatial and functional integration of secretory membrane traffic.
Lippincott-Schwartz
J
J
Cell Biology and Metabolism Branch, NICHD, National Institute for Health, Bethesda, MD 20892-0001, USA. jlippin@helix.nih.gov
D000818:Animals; D003598:Cytoskeletal Proteins / Q000502:physiology*; D006056:Golgi Apparatus / Q000378:metabolism*; D008870:Microtubules / Q000502:physiology
D003598:Cytoskeletal Proteins