Atypical dendritic cell-related histiocytosis with goiter and primary hypothyroidism.
Langerhans cell histiocytosis may be seen with goiter and histiocytic infiltration of the thyroid. We report a 2 1/2-year-old boy who had goiter and primary hypothyroidism develop, later had pulmonary disease, and died of neurologic involvement. Autopsy lesions suggested a transitional dendritic cell precursor of the epidermal Langerhans cell. Of the reported cases of Langerhans cell histiocytosis with goiter in children and adolescents, 82% were male when the relative incidence of Langerhans cell histiocytosis is two males to one female.
Diamond
F B
FB
Department of Pediatrics, University of South Florida College of Medicine, Tampa, USA.
Shulman
D I
DI
Lacson
A
A
Casadonte
J
J
Favara
B
B
D002675:Child, Preschool; D003713:Dendritic Cells; D017809:Fatal Outcome; D006042:Goiter / Q000150:complications* / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000473:pathology; D008297:Male; D013961:Thyroid Gland / Q000473:pathology