Oxidative stress and enzyme activity in ambulatory renal patients undergoing continuous peritoneal dialysis.
Some parameters indicating the possibility of oxidative stress in chronic renal failure patients (CRF) undergoing continuous ambulatory peritoneal dialysis (CAPD), are presented in this study. Oxidative stress appears to be lower than in hemodialysis patients. In a group of CRF patients and in a control group malondialdehyde (MDA) was determined as an indicator of red-blood-cell membrane lipid peroxidation. Also, the three glutathione forms, total (GST), oxidated (GSSG) and reduced (GSH) and the levels of glutathione peroxidase (GPX), the levels of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) have been measured. Significantly higher MDA values (p < .05) have been found in CRF patients when compared to controls. The three forms of glutathione and GPX are also significantly decreased in the CRF group (p < .05 and p < .001, respectively). The levels of SOD and CAT are increased with respect to the control group (p < .001).
Martin-Mateo
M C
MC
Department of Biochemistry, Molecular Biology and Physiology, Faculty of Sciences, University of Valladolid, Spain.
del Canto-Jafiez
E
E
Barrero-Martinez
M J
MJ
D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy*; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D010531:Peritoneal Dialysis, Continuous Ambulatory; D013482:Superoxide Dismutase / Q000378:metabolism
D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione