Changes of plasma level of neurotensin, somatostatin, and dynorphin A in pilots under acute hypoxia.
This study examined the effect of high-altitude exposure on the plasma levels of certain peptides in the regulation of heart and blood vessels. The plasma levels of dynorphin A, neurotensin, and somatostatin were measured in 30 pilots before and after exposure to hypoxia in an altitude chamber. The results showed that plasma concentrations of the three peptides were increased significantly after exposure to hypoxia. In the test group, 18 pilots lived on a plateau (1,725 m above sea level); the other 12 pilots lived on a plain (208 m above sea level). When exposed to hypoxia, the three peptides increased significantly in the plateau group, but in the plain group, neurotensin and dynorphin A increased but somatostatin had no significant change. These results indicate that these peptides might participate in the regulation of cardiovascular activities under hypoxia.
Shen
D
D
Department of Nuclear Medicine, Space Central Hospital, No. 15 Yu Quan Lu, Beijing, People's Republic of China.
Wang
Y
Y
D000328:Adult; D000337:Aerospace Medicine; D000531:Altitude; D001273:Atmosphere Exposure Chambers; D016022:Case-Control Studies; D004399:Dynorphins / Q000097:blood*; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000503:physiopathology; D008297:Male; D009496:Neurotensin / Q000097:blood*; D013004:Somatostatin / Q000097:blood*
D009496:Neurotensin; D013004:Somatostatin; D004399:Dynorphins