title: Traumatic brain injury-associated delayed sleep phase syndrome.
abstract: A 15-year-old girl developed a prominent delayed sleep phase syndrome (DSPS) following traumatic brain injury. Several physiological markers of the sleep-wake rhythm: plasma melatonin, body temperature, wrist activity and sleep architecture (EEG) were delayed almost half a day, returning to normal after treatment with 5 mg melatonin. This report suggests an association between traumatic brain injury and DSPS. Awareness of this phenomenon may result in better possibilities for treatment of patients with brain injury.
authors.affiliation: Department of Clinical Pharmacy, Hospital de Gelderse Vallei, Bennekom, The Netherlands.
authors.forename: J E
authors.initials: JE
authors.lastname: Nagtegaal
authors.forename: G A
authors.initials: GA
authors.lastname: Kerkhof
authors.forename: M G
authors.initials: MG
authors.lastname: Smits
authors.forename: A C
authors.initials: AC
authors.lastname: Swart
authors.forename: Y G
authors.initials: YG
authors.lastname: van der Meer
mesh_terms: D000293:Adolescent; D001831:Body Temperature / Q000502:physiology; D001930:Brain Injuries / Q000150:complications*; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D008550:Melatonin / Q000097:blood / Q000627:therapeutic use; D008991:Monitoring, Physiologic; D012007:Rectum / Q000503:physiopathology; D012894:Sleep Stages / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D013577:Syndrome; D013997:Time Factors
chemical_list: D008550:Melatonin