Effect of nitric oxide on poliovirus infection of two human cell lines.
The role of nitric oxide after poliovirus infection of the human HeLa (carcinoma) and U937 (promonocytic) cell lines has been analyzed. Both types of cells produced detectable levels of nitric oxide after poliovirus infection. However, this production was not sufficient to limit viral productivity. On the other hand, pretreatment with the nitric oxide donor glycerine trinitrate lengthened the course of poliovirus infection.
López-Guerrero
J A
JA
Centro de Biología Molecular, CSIC-UAM, Spain. JALOPEZ@TRASTO.CBM.UAM.ES
Carrasco
L
L
D006367:HeLa Cells; D006801:Humans; D009569:Nitric Oxide / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D017955:Poliovirus / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000032:analysis
D014764:Viral Proteins; D009569:Nitric Oxide; D005996:Nitroglycerin