Trypanocidal effects of gallic acid and related compounds.
Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally abundant plant phenolic compound and it is well known as a component of hydrolyzable tannins. We report here that gallic acid and related compounds have trypanocidal activity against Trypanosoma brucei brucei (GUTat 3.1) in both the long slender bloodstream forms and the procyclic forms, in vitro. LD50 values of gallic acid are 46.96 +/- 1.28 microM for bloodstream forms and 30.02 +/- 3.49 for procyclic forms, respectively. A study of structurally related compounds suggested that the pyrogallol moiety could be responsible for this activity.
Koide
T
T
Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Nose
M
M
Inoue
M
M
Ogihara
Y
Y
Yabu
Y
Y
Ohta
N
N
D000818:Animals; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D051379:Mice; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects*
D014344:Trypanocidal Agents; D005707:Gallic Acid