title: The role of hypoxic stop-flow perfusion and high dose chemotherapy in the treatment of regionally advanced colorectal cancer.
abstract: The primary or secondary forms of colorectal cancers involving local structures or spreading in the abdomen or pelvic area without extra-regional metastases are identified as regionally advanced colorectal cancers (RACRC). They are unresectable and thus radiotherapy and chemotherapy are the fundamental treatment methods. However, these regimens have failed to check the diffusion of tumor satisfactorily in most forms of RACRC. The abdominal and pelvic regions can be isolated from corporal circulation by temporary occlusion of the aorta and cava and perfused with high doses of chemotherapeutic drugs. The hypoxic abdominal or pelvic stop-flow method for delivering high-dose antiblastic agents to these body districts to avoid toxicity by chemofiltration has been suggested. This study examines the possibility of using this method to treat various forms of RACRC.
authors.affiliation: I Istituto di Clinica Chirurgia-Università La Sapienza Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Di Giorgio
authors.forename: F
authors.initials: F
authors.lastname: Franchi
authors.forename: M
authors.initials: M
authors.lastname: Di Seri
authors.forename: V
authors.initials: V
authors.lastname: Lacava
authors.forename: S
authors.initials: S
authors.lastname: Caroli
authors.forename: G E
authors.initials: GE
authors.lastname: Russo
authors.forename: V
authors.initials: V
authors.lastname: Borzomati
authors.forename: M
authors.initials: M
authors.lastname: Al Mansour
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006440:Hemofiltration; D006801:Humans; D007558:Italy; D009361:Neoplasm Invasiveness; D010386:Pelvic Neoplasms / Q000188:drug therapy; D012042:Registries; D016896:Treatment Outcome