title: Blood usage in lung transplantation.
abstract: BACKGROUND
  Few published data are available regarding perioperative blood usage in lung transplantation.
  
  
  METHODS
  The medical records of all patients undergoing lung transplantation at a university medical center in 1994 and 1995 were reviewed.
  
  
  RESULTS
  Ninety patients underwent lung transplantation during this period. Six patients were excluded: two received a living related-donor lung, three underwent retransplantation and one underwent concomitant repair of a tetralogy of Fallot. Of the 84 evaluable patients, 59 underwent single lung transplantation and 25 double lung transplantation. Double-lung recipients used more red cells (6.4 vs. 1.7 units, p = 0.0002) and were more likely to receive red cells, platelets, plasma, or any component (92 vs. 32%, p< or =0.0001) than were single-lung recipients. Double-lung recipients were more likely to require cardiopulmonary bypass (40 vs. 12%, p = 0.003), and cardiopulmonary bypass was associated with greater transfusion requirements (p< or =0.0001). However, among patients requiring cardiopulmonary bypass, blood use did not differ between those undergoing double lung transplantation and those undergoing single lung transplantation. In the subset of patients not requiring cardiopulmonary bypass, double-lung recipients received more red cells (4.5 vs. 0.7 units, p< or =0.0001) and more plasma (2.0 vs. 0.2 units, p = 0.006).
  
  
  CONCLUSIONS
  Double-lung recipients require more perioperative transfusions than single-lung recipients. The greater transfusion requirement is due to the more frequent need for cardiopulmonary bypass as well as the greater complexity of the procedure. These data are useful for developing surgical blood ordering guidelines for lung transplantation.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Triulzi
authors.forename: B P
authors.initials: BP
authors.lastname: Griffith
mesh_terms: D000328:Adult; D016913:Blood Component Transfusion / Q000706:statistics & numerical data*; D005260:Female; D006301:Health Services Needs and Demand; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care