title: [The effect of brain peptides on nerve tissue cells in vitro].
abstract: The effect of cortexin and epithalamin on the cell growth rate was investigated in the organotypic tissue culture of dorsal root ganglia (DRG), and of cortex and subcortical structures of 10-11-day old chick embryos. Cortexin in concentrations of 20 and 100 ng/ml is active, inducing a more intensive neurite outgrowth in DRG, compared to the control. Epithalamin was active in concentrations 20 and 200 ng/ml. Cortexin (100 ng/ml) was active in the cortex tissue culture, but inhibited the neurite growth in the subcortical structures culture. The stimulation of this culture to development was evident after using 200 ng/ml epithalamin. The neurite stimulating effect of cortexin and epithalamin is presumably associated with neurotrophic factors.
authors.affiliation: Institute of Bioregulation and Gerontology, St. Petersburg.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: V G
authors.initials: VG
authors.lastname: Morozov
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.forename: V B
authors.initials: VB
authors.lastname: Okulov
mesh_terms: D000818:Animals; D002417:Cattle; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects*; D002642:Chick Embryo; D003470:Culture Media; D046508:Culture Techniques; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D019261:Epithalamus; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects*; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides / Q000494:pharmacology*; D013268:Stimulation, Chemical
chemical_list: D003470:Culture Media; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C027437:epithalamin; C056590:cortexin
vernacular_title: Vliianie peptidov golovnogo mozga na kletki nervnoĭ tkani in vitro.