title: Treatment of diastolic dysfunction in hypertensive patients without left ventricular hypertrophy.
abstract: The aim of this study was to evaluate the influence of verapamil SR 240 mg (V) and the combination amiloride 5 mg + hydrochlorothiazide 50 mg (AH) on diastolic dysfunction of hypertensive patients without left ventricular hypertrophy (LVH). Twenty-six hypertensive patients with diastolic dysfunction, normal systolic function and without LVH were included into a 2-week washout period and then randomised to a 6-month V or AH treatment. One blinded-to-treatment echocardiographist at baseline and at weeks 4, 12 and 24 assessed Doppler-echocardiography. Both V and AH, satisfactorily controlled blood pressure, but only V improved diastolic function shown by a tendency to reduce peak A and to increase peak E/A ratio, and by a significant reduction in deceleration time. After 24 weeks, V significantly reduced wall thickness in comparison with AH. These results need to be confirmed in a larger scale study.
authors.affiliation: Cardiology Service, Basurto Hospital, Bilbao, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Molinero
authors.forename: N
authors.initials: N
authors.lastname: Murga
authors.forename: J D
authors.initials: JD
authors.lastname: Sagastagoitia
authors.forename: R
authors.initials: R
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: Garrido
mesh_terms: D000328:Adult; D000368:Aged; D000584:Amiloride / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D018754:Ventricular Dysfunction / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D004232:Diuretics; D006852:Hydrochlorothiazide; D000584:Amiloride; D014700:Verapamil