Cystitis and interstitial nephritis related to the use of tiaprofenic acid (Surgam).
We describe a case of concurrent presentation of severe haemorrhagic cystitis and acute interstitial nephritis with eventually lethal outcome, associated with the use of tiaprofenic acid (Surgam), a propionic acid-derived non-steroidal anti-inflammatory drug (NSAID). Although interstitial nephritis and haemorrhagic cystitis are caused by all types of NSAIDs, a higher incidence of interstitial nephritis and especially haemorrhagic cystitis has been described related to propionic acid derivatives. Awareness of this serious adverse effect is important.
van Gameren
I I
II
Department of Internal Medicine, Martini Hospital LvS, Groningen.
Gökemeijer
J D
JD
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D018771:Arthralgia / Q000188:drug therapy; D003556:Cystitis / Q000139:chemically induced* / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced* / Q000150:complications; D006801:Humans; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000150:complications; D011422:Propionates / Q000009:adverse effects* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid