Mediators of inflammation.
Therapeutic studies and genetically engineered animals have elucidated the inflammatory roles of cytokines and chemokines in autoimmune disease. Most unexpected has been a continuum of recent evidence demonstrating that inflammatory mediators are crucial in lymphoid organ development, thus suggesting that these hitherto unrelated processes have common elements with implications for determinant spreading.
Sacca
R
R
Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06520-8034, USA.
Cuff
C A
CA
Ruddle
N H
NH
D000818:Animals; D030801:Animals, Genetically Modified; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D016207:Cytokines