title: [Optimisation of epilepsy monotherapy (clinico-pharmacological study)].
abstract: The effect of four preparations (benzonal, phenobarbital, diphenyn, finlepsin), were examined in 214 epileptic patients with different forms of the fits. The advantages of monotherapy of epilepsy were grounded and therapeutic possibilities of the drugs were considered by means of clinico-pharmacological study. Standard and intensive methods of treatment of different forms of the fits were considered. It is demonstrated that maximal usage of therapeutic possibilities of the drugs resulted in the increase of the efficiency of treatment 2.5-fold. Daily doses and blood levels of the preparations were elevated, respectively. The term of "pseudotherapy" is grounded.
authors.forename: S A
authors.initials: SA
authors.lastname: Gromov
authors.forename: S K
authors.initials: SK
authors.lastname: Khorshev
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001463:Barbiturates / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002220:Carbamazepine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D005500:Follow-Up Studies; D006207:Half-Life; D006801:Humans; D010634:Phenobarbital / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010672:Phenytoin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D001463:Barbiturates; D002220:Carbamazepine; D010672:Phenytoin; C002915:benzobarbital; D010634:Phenobarbital
vernacular_title: Optimizatsiia monoterapii épilepsii (kliniko-farmakologicheskoe issledovanie).