title: Applications of mass spectrometry to the characterization of oligonucleotides and nucleic acids.
abstract: Mass spectrometry-based techniques continue to undergo active development for applications to nucleic acids, fueled by methods based on electrospray and matrix-assisted laser desorption ionization. In the past two years, notable advances have occurred in multiple interrelated areas, including sequencing techniques for oligonucleotides, approaches to mixture analysis, microscale sample handling and targeted DNA assays, and improvements in instrumentation for greater sensitivity and mass resolution.
authors.affiliation: University of Utah, Department of Medicinal Chemistry, Salt Lake City 84112-5820, USA. pamela.crain@rna.pharm.utah.edu
authors.forename: P F
authors.initials: PF
authors.lastname: Crain
authors.forename: J A
authors.initials: JA
authors.lastname: McCloskey
mesh_terms: D002853:Chromatography, Liquid; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D009841:Oligonucleotides / Q000032:analysis* / Q000737:chemistry*; D017422:Sequence Analysis, DNA / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
chemical_list: D009841:Oligonucleotides