title: Extreme insulin resistance: clinical management by external subcutaneous insulin infusion.
abstract: Management of very high insulin requirements in rare extreme insulin resistance syndromes is difficult and poorly documented. We report a case of a type B insulin-resistant patient requiring approximately 10,000 units of insulin per day, i.e. beyond the possibilities of current insulin formulations and delivery devices. Only the Panomat C10 portable pump model (Disetronic) and U500 Humulin (Lilly) allowed the required rate of 400 units per hour to be attained only when the reservoir was changed twice daily and the site and catheter were changed once daily. Three months after discharge, the patient was in good general and local condition, but with only fair diabetes control (glycated haemoglobin 9.5%).
authors.affiliation: Department of Diabetology, INSERM U. 341, Hotel-Dieu Hospital, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Lalej-Bennis
authors.forename: J L
authors.initials: JL
authors.lastname: Selam
authors.forename: S
authors.initials: S
authors.lastname: Fluteau-Nadler
authors.forename: J
authors.initials: J
authors.lastname: M'Bemba
authors.forename: G
authors.initials: G
authors.lastname: Reach
authors.forename: G
authors.initials: G
authors.lastname: Sorel
authors.forename: C
authors.initials: C
authors.lastname: Bardin
authors.forename: P
authors.initials: P
authors.lastname: Zirinis
authors.forename: F
authors.initials: F
authors.lastname: Chast
authors.forename: F
authors.initials: F
authors.lastname: Elgrably
authors.forename: G
authors.initials: G
authors.lastname: Slama
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006029:Glycosuria; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D007332:Insulin Infusion Systems; D007333:Insulin Resistance; D010951:Plasma Exchange
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin