Mechanisms of chemically induced renal carcinogenesis in the laboratory rodent.
Laboratory studies with classical renal carcinogens in the rat and mouse, as well as research investigation with some of the chemicals proving positive for the kidney in National Toxicology Program carcinogenicity bioassays, have demonstrated the existence of a range of diverse mechanisms underlying rodent kidney carcinogenesis. The classical carcinogens used as experimental models for studying renal tumor pathogenesis, such as the nitrosamines, are genotoxic and interact directly with DNA, forming DNA adducts with mutagenic potential. In contrast, potassium bromate and ferric nitrilotriacetate (Fe-NTA), also effective renal carcinogens, appear to cause indirect damage to DNA mediated by oxidative stress. A number of nongenotoxic chemicals are associated with epigenetic renal tumor induction in rodents, and the activity of these tends to involve prolonged stimulation of cell proliferation throughout the duration of exposure. This mode of action reflects a sustained regenerative response, either due to direct chemical toxicity to the tubule cells, as with chloroform, or to indirect cytotoxicity associated with lysosomal overload, as in alpha2u-globulin accumulation in male rats resulting from the administration of such chemicals as d-limonene and tetrachloroethylene. The histopathologic nature of hydroquinone renal carcinogenesis suggests that an additional epigenetic pathway to renal tubule tumor formation in rats may be through chemical-mediated exacerbation of, and interaction with, the age-related spontaneous renal disease, chronic progressive nephropathy. These various mechanistic pathways have implications for the nature of the induced cancer process with respect to tumor incidence, latency, malignancy, and sex predisposition.
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American Health Foundation, Valhalla, New York 10595, USA.
D000818:Animals; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D002455:Cell Division; D004273:DNA, Neoplasm / Q000187:drug effects; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000235:genetics; D007684:Kidney Tubules / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D051437:Renal Insufficiency / Q000139:chemically induced / Q000473:pathology
D002273:Carcinogens; D004273:DNA, Neoplasm