Relation of von Willebrand factor to occurrence of Q waves and thrombolytic treatment in acute myocardial infarction.
We measured the changes of plasma von Willebrand factor antigen and fibrinogen levels in patients with acute myocardial infarction treated with recombinant tissue plasminogen activator and patients not given fibrinolytic drugs. The von Willebrand factor levels are greater in patients with Q-wave than in patients with non-Q-wave myocardial infarction and are independent of thrombolytic treatment. Fibrinogen levels are depressed by thrombolytic treatment but are unrelated to the presence or absence of Q waves.
Tousoulis
D
D
Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece.
Davies
G
G
Tentolouris
C
C
Bosinakou
E
E
Toutouzas
P
P
D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005260:Female; D005340:Fibrinogen / Q000187:drug effects / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D010959:Tissue Plasminogen Activator / Q000494:pharmacology / Q000627:therapeutic use*; D014841:von Willebrand Factor / Q000187:drug effects / Q000378:metabolism*
D005343:Fibrinolytic Agents; D014841:von Willebrand Factor; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator