Role of dentinal carious lesions in the pathogenesis of oral candidiasis in HIV infection.
The authors describe a clinicopathologic study that evaluated whether dentinal carious lesions are colonized by candidal organisms--and if so, whether there is a relationship between dentinal carious lesion colonization and clinical oral candidiasis, or OC, in HIV infection. Using light microscopy, the authors examined 30 extracted teeth with dentinal carious lesions from people in each of two groups: 30 consecutively treated HIV-positive patients and 30 consecutively treated HIV-negative patients. OC was diagnosed only in HIV-positive patients (40 percent). The dentinal carious lesion pattern in both groups was similar in occlusal, root and proximal caries. Candidal colonization of carious dentinal tubules was more frequent in HIV-positive subjects than it was in HIV-negative subjects. This research shows that it may be important to restore dentinal caries in HIV-infected patients to remove a protected niche for candidal organisms.
Jacob
L S
LS
University of Texas-Houston Health Science Center, Dental Branch, USA.
Flaitz
C M
CM
Nichols
C M
CM
Hicks
M J
MJ
D017088:AIDS-Related Opportunistic Infections / Q000209:etiology* / Q000517:prevention & control; D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D000704:Analysis of Variance; D002175:Candida / Q000254:growth & development*; D002180:Candidiasis, Oral / Q000209:etiology* / Q000517:prevention & control; D016009:Chi-Square Distribution; D015169:Colony Count, Microbial; D004396:Coloring Agents; D003731:Dental Caries / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D003793:Dental Restoration, Permanent; D003804:Dentin / Q000382:microbiology* / Q000473:pathology; D005260:Female; D005456:Fluorescent Dyes; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000382:microbiology; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D016612:Paraffin Embedding; D012307:Risk Factors; D017213:Root Caries / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D012907:Smoking / Q000009:adverse effects; D015819:Substance Abuse, Intravenous / Q000150:complications
D004396:Coloring Agents; D005456:Fluorescent Dyes