[The pathogenetic characteristics of the anemic syndrome in liver cirrhosis].
Overall sixty-two patients, in different age brackets, with cirrhosis of the liver were examined. Of these, 42 presented with anemia, while 20 with no anemia. All patients were evaluated for activity of lipid peroxidation and state of the antioxidant systems. Cirrhotic patients with anemia displayed more profound dysfunction of antioxidant systems. This led to disorganization of the erythrocytic membranes' lipid and protein components, worsening of their rheologic properties, causing morbid shifts in the receptors' function. The above pathologies combined affect the degree of anemia in cirrhotic patients. Anemic syndrome in this patient population was managed with anaprilin, a beta-adrenoblocker.
Tymofieiev
V V
VV
Kolomoiets'
M Iu
MIu
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D002395:Catecholamines / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use; D013577:Syndrome
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D005609:Free Radicals; D011433:Propranolol
Patohenetychni osoblyvosti anemichnoho syndromu pry tsyrozi pechinky.