[Activity of glutathione-S-transferase in the blood plasma, liver and crystalline lens tissues as affected by low doses of ionizing radiation and polychromatic light].
The developmental dynamics of pathologic changes in the lenses and activity of glutathione-S-transferase in the blood plasma, liver and lens tissues of rabbits under chronic influence (2 months) of small doses of X-ray radiation (total dose 2 Gy) and polychromatic light have been researched. It was shown, that polychromatic light and X-ray irradiation of rabbits significantly affected the lens nativity and increased the developmental frequency and the intensity of lens opacities. It was determined, that activity of glutathione-S-transferase in blood plasma increased for 1 month after the beginning of X-ray effects. The same effect on the enzymatic activity was shown by the summary influence of polychromatic light and X-ray irradiation. Glutathione-S-transferase activity decreased during 2 months as compared with the initial values, before irradiation of the animals. The enzymatic activity was increased in rabbit-liver cytoplasm by X-ray irradiation in 2 months. A decrease of glutathione-S-transferase activity in the liver, cortex and lens nucleus was determined under the influence of both X-ray radiation and polychromatic light.
Leus
N F
NF
V.P. Filatov Institute of Eye Diseases and Tissue Therapy, Academy of Medical Sciences of Ukraine, Odessa.
Kolomiĭchuk
S G
SG
Lishchenko
V B
VB
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005982:Glutathione Transferase / Q000097:blood / Q000378:metabolism / Q000528:radiation effects*; D007908:Lens, Crystalline / Q000201:enzymology / Q000528:radiation effects*; D008027:Light; D008099:Liver / Q000201:enzymology / Q000528:radiation effects*; D008297:Male; D011817:Rabbits
D005982:Glutathione Transferase
Aktivnost' glutation-S-transferazy v plazme krovi, tkaniakh pecheni i khrustalika glaz v usloviiakh deĭstviia nizkikh doz ioniziruiushchego izlucheniia i polikhromnogo sveta.