Analysis of selected diphosphonic acid derivatives used in treatment of osteoporosis. Part I. Complexometric determination of diphosphonic acid derivatives.
The purpose of the study was to develop a simple method for determination of diphosphonic acid derivatives in pharmaceutical preparations used in treatment of osteoporosis: disodium etidronate, disodium clodronate, disodium tiludronate, disodium pamidronate, sodium alendronate. The analysis performed by the visual end point titration method with complexing reagent Th(DCTA) in presence of xylenol orange used the ability of these compounds to form complexes.
Podolska
M
M
Drug Institute, Warsaw, Poland.
Białecka
W
W
Kwiatkowska-Puchniarz
B
B
Tuszyńska
E
E
D019386:Alendronate / Q000032:analysis; D018712:Analgesics, Non-Narcotic / Q000032:analysis; D004002:Clodronic Acid / Q000032:analysis; D004164:Diphosphonates / Q000032:analysis* / Q000737:chemistry; D012968:Etidronic Acid / Q000032:analysis; D010024:Osteoporosis / Q000188:drug therapy; D000077268:Pamidronate; D017186:Titrimetry / Q000379:methods*
D018712:Analgesics, Non-Narcotic; D004164:Diphosphonates; D004002:Clodronic Acid; C058651:tiludronic acid; D012968:Etidronic Acid; D000077268:Pamidronate; D019386:Alendronate