title: Accurate and precise measurement of heteronuclear long-range couplings by a gradient-enhanced two-dimensional multiple-bond correlation experiment.
abstract: We propose a phase-sensitive gradient-enhanced two-dimensional heteronuclear multiple-bond correlation (psge-2D HMBC) experiment for speedy, accurate, and precise measurement of 2JCH and 3JCH. The experiment does not suppress one-bond correlations. Rather, the value of a desired long-range JCH is obtained from the pertinent cross-peak pattern in the HMBC spectrum, using the corresponding 1JCH correlation pattern as reference. The application of the proposed experiment is illustrated for the trisaccharide raffinose.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia, 30303-3083, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sheng
authors.forename: H
authors.initials: H
authors.lastname: van Halbeek
mesh_terms: D005583:Fourier Analysis; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D011887:Raffinose / Q000737:chemistry*; D015203:Reproducibility of Results; D012984:Software
chemical_list: D011887:Raffinose