Association between HLA-A1 allele and schizophrenia gene(s) in patients refractory to conventional neuroleptics but responsive to clozapine medication.
We report an association between HLA-A1 allele and a subgroup of schizophrenic patients refractory to conventional neuroleptic treatment but responsive to clozapine. The frequency of HLA-A1 was 58% among the schizophrenic patients not responding to conventional treatment but responsive to clozapine but only 10.5% among the patients responding to conventional neuroleptics. The HLA-A1 occurs in 20% of the random Finnish population. Our results indicate that HLA-A1 defines a subgroup of schizophrenic patients with a selective response to neuroleptics.
Lahdelma
L
L
Department of Pathology, Haartman Institute, University of Helsinki, Finland.
Ahokas
A
A
Andersson
L C
LC
Huttunen
M
M
Sarna
S
S
Koskimies
S
S
D000328:Adult; D000483:Alleles; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use; D005260:Female; D005387:Finland; D005787:Gene Frequency; D008040:Genetic Linkage; D015788:HLA-A1 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology*
D014150:Antipsychotic Agents; D015788:HLA-A1 Antigen; D003024:Clozapine