title: The improved image of indocyanine green angiography in young healthy volunteers.
abstract: OBJECTIVE
  The authors performed indocyanine green (ICG) angiography in healthy volunteers using a high resolution ICG video system to obtain baseline images for subsequent studies.
  
  
  METHODS
  Ten eyes of 10 healthy, young volunteers were studied. Before ICG angiography, all eyes were examined ophthalmoscopically and biomicroscopically and found to be intact. Indocyanine green (50 mg) dissolved in 2 mL of distilled water was injected through the antecubital vein. Video ICG angiogram was recorded until 30 minutes after the dye injection.
  
  
  RESULTS
  Although the choroidal dye filling varied among subjects, it always began in the macular area. In the 10 volunteers, initial dye filling had two patterns: flush (n = 2) and reticular (n = 8). Patchy dye-filling delay in the posterior fundus was a common finding (n = 9). Vertical filling delay running between the medial and nasal cilial arteries was observed in nine eyes. The choroidal circulation filled completely before the retinal circulation did. At 30 minutes after dye injection, interstitial tissue staining of the choroid and vascular silhouette resulting from dye washout was observed in all eyes.
  
  
  CONCLUSIONS
  Arterioles and capillaries of the choroid were well delineated by ICG angiography, resulting in better understanding of the physiologic and pathologic conditions of the choroidal circulations and the chorioretina itself.
authors.affiliation: Department of Ophthalmology, Saitama Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yoneya
authors.forename: Y
authors.initials: Y
authors.lastname: Komatsu
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Deguchi
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: J
authors.initials: J
authors.lastname: Young-Duvall
mesh_terms: D000328:Adult; D002829:Choroid / Q000098:blood supply*; D005260:Female; D005451:Fluorescein Angiography; D005456:Fluorescent Dyes / Q000008:administration & dosage; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D008297:Male; D012016:Reference Values; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000502:physiology
chemical_list: D005456:Fluorescent Dyes; D007208:Indocyanine Green