title: Analysis of FcgammaRII gene polymorphisms in Wegener's granulomatosis.
abstract: Fcgamma receptors (FcgammaRs) are potent initiators of proinflammatory reactions and tissue injury programs through the oxidative burst, degranulation and the production of a variety of proinflammatory cytokines. Direct experimental evidence indicates that translocation of ANCA target from intracellular granules to the neutrophil membrane and subsequent binding of ANCA enables FcgammaR-mediated neutrophil activation. In the presence of ANCA, these data provide a framework from which to understand the importance of ANCA class, subclass, and titer in Wegener's granulomatosis and other ANCA-positive vasculitides. The well-characterized and functionally important alleles of neutrophil FcgammaR (FcgammaRIIa-H131/R131 and FcgammaRIIIb-NA1/NA2) are possible inheritable genetic elements that may alter disease severity and/or phenotype.
authors.affiliation: Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 35294-0006, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Edberg
authors.forename: E
authors.initials: E
authors.lastname: Wainstein
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: E
authors.initials: E
authors.lastname: Csernok
authors.forename: M C
authors.initials: MC
authors.lastname: Sneller
authors.forename: G S
authors.initials: GS
authors.lastname: Hoffman
authors.forename: E C
authors.initials: EC
authors.lastname: Keystone
authors.forename: W L
authors.initials: WL
authors.lastname: Gross
authors.forename: R P
authors.initials: RP
authors.lastname: Kimberly
mesh_terms: D000483:Alleles; D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology; D014890:Granulomatosis with Polyangiitis / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics* / Q000276:immunology
chemical_list: D015703:Antigens, CD; C080568:Fc gamma receptor IIA; D007074:Immunoglobulin G; D017452:Receptors, IgG