[The effect of cyclooxygenase inhibitors on ion and water transport in the human kidney and frog skin and bladder].
In the frog urinary bladder and skin, block of cyclooxygenase with diclofenac (voltaren) resulted in an increase in the water permeability and a decrease in the potential difference and short-circuit current. Addition of 0.01 mumole of prostaglandine E2 decreased the osmotic water permeability to initial values and increased the transepithelial ion transport in the frog skin. In the kidney of children with nocturnal enuresis there was an increase in the night diuresis and in excretion of osmotically active substances. Voltaren by reducing the endogenous autacoid production, restored the kidney function and symptoms of enuresis disappeared. The results obtained indicate an important role of the rate of the endogenous autacoid production in regulation of the water and ion transport in the osmoregulating organs studied.
Shakhmatova
E I
EI
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg, Russia.
Kuznetsova
A A
AA
Prutskova
N P
NP
Bogolepova
A E
AE
Natochin
Iu V
IuV
D000293:Adolescent; D000818:Animals; D002648:Child; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D006801:Humans; D017136:Ion Transport / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D011896:Rana temporaria; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D001743:Urinary Bladder / Q000187:drug effects* / Q000378:metabolism; D019459:Urothelium / Q000187:drug effects / Q000378:metabolism; D014867:Water / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D016861:Cyclooxygenase Inhibitors; D014867:Water
Vliianie ingibitorov tsiklooksigenazy na transport ionov i vody v pochve cheloveka, kozhe i mochevom puzyre liagushki.