2-Mercapto-N-(azolyl)benzenesulphonamides. IV. Syntheses of some 4-chloro-2-mercapto-5-methyl-N-(benzimidazol-2-yl)benzenesulph onamide derivatives with potential anticancer and anti-HIV activities.
Syntheses of 4-chloro-2-mercapto-5-methyl-N-(5-R1-6-R2-benzimidazol-2-yl) benzenesulphonamides [II-V], their disulfides [IIa-IVa] and S,N-substituted derivatives [VI-IX] were described. The probable mechanism for the reactions was suggested. The moderate anticancer activity was observed in vitro for compounds [II-IV].
Pomarnacka
E
E
Department of Chemical Drug Technology, Medical University of Gdańsk, Poland.
Brzozowski
Z
Z
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D001562:Benzimidazoles; D013449:Sulfonamides