title: Norethisterone therapy for bleeding due to gastrointestinal telangiectases in Glanzmann's thrombasthenia.
abstract: We report a case of a patient with Glanzmann's thrombasthenia and anti-GPIIb/IIIa alloantibodies who developed life-threatening and intractable bleeding from gastrointestinal telangiectatic lesions. After a period of transfusion-dependent gastrointestinal bleeding despite tranexamic acid, oral iron, omeprazole and platelet transfusions, the use of oral norethisterone produced a significant improvement with a marked reduction in her transfusion requirements.
authors.affiliation: Department of Haematology, Royal Hallamshire Hospital, Sheffield.
authors.forename: M
authors.initials: M
authors.lastname: Leach
authors.forename: M
authors.initials: M
authors.lastname: Makris
authors.forename: K K
authors.initials: KK
authors.lastname: Hampton
authors.forename: F E
authors.initials: FE
authors.lastname: Preston
mesh_terms: D000328:Adult; D001803:Blood Transfusion; D002908:Chronic Disease; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D009640:Norethindrone / Q000627:therapeutic use*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D045167:Progesterone Congeners / Q000627:therapeutic use*; D013684:Telangiectasis / Q000150:complications*; D013915:Thrombasthenia / Q000150:complications*
chemical_list: D007518:Isoantibodies; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D045167:Progesterone Congeners; D009640:Norethindrone