title: Pretreatment plasma HVA predicts neuroleptic response in manic psychosis.
abstract: Elevated pretreatment plasma free homovanillic acid (HVA) predicted acute response to neuroleptic treatment in patients with manic psychosis. These findings suggest that plasma HVA may be a useful predictor of a successful short-term response in manic as well as schizophrenic psychoses, and that elevated pre-synaptic dopaminergic release may play a role in more than one group of psychotic disorders.
authors.affiliation: Yale University School of Medicine, Department of Psychiatry, Yale New Haven Hospital, CT 06504, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Mazure
authors.forename: M B
authors.initials: MB
authors.lastname: Bowers
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006220:Haloperidol / Q000494:pharmacology* / Q000627:therapeutic use*; D006719:Homovanillic Acid / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D008875:Middle Aged; D010546:Perphenazine / Q000494:pharmacology* / Q000627:therapeutic use*; D011379:Prognosis
chemical_list: D014150:Antipsychotic Agents; D008734:Methoxyhydroxyphenylglycol; D010546:Perphenazine; D006220:Haloperidol; D006719:Homovanillic Acid