Detection of Epstein-Barr virus DNA in cerebrospinal fluid from immunocompetent individuals with brain disorders.
Fifty four cerebrospinal fluid samples obtained from as many immunocomponent patients with disorders of the central nervous system were investigated for the presence of herpesvirus DNA by nested polymerase chain reaction in order to determine an etiological diagnosis. Four of these samples proved positive for the presence of Epstein-Barr virus DNA (7.4%). The result of this diagnostic study is reported to draw insiders' attention to the possible presence of EBV in cerebrospinal fluid from patients with central nervous system diseases.
Portolani
M
M
Department of Biomedical Sciences, University of Modena, Italy.
Pietrosemoli
P
P
Meacci
M
M
Sabbatini
A M
AM
Pecorari
M
M
Mantovani
G
G
Cermelli
C
C
D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000821:virology*; D004279:DNA, Viral / Q000134:cerebrospinal fluid*; D006564:Herpesviridae / Q000235:genetics / Q000302:isolation & purification; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007121:Immunocompetence; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D004279:DNA, Viral