title: Altered expression of the cell cycle regulatory protein cyclin D1 in the rat dentate gyrus after adrenalectomy-induced granular cell loss.
abstract: The loss of dentate gyrus (DG) granular cells after removal of the rat adrenal glands (ADX) is mediated by a process that is apoptotic in nature. The present study was initiated to compare changes in the immunocytochemical distribution of the cell-cycle regulatory protein cyclin D1, which has been implicated in apoptosis, with the loss of DG granular cells after ADX. Our data indicate that cyclin D1-immunoreactivity (cyclin D1-ir) is enhanced in the rat dentate gyrus after adrenalectomy. The enhanced cyclin D1-ir shows a close relationship, both in time and space, with granular cell loss in the rat dentate gyrus that occurs after adrenalectomy. However, the enhanced cyclin D1-immunoreactivity was present in microglia and radial glia rather than in the dentate gyrus granular cells. This suggests that cyclin D1 is not directly involved in apoptosis of granular cells in the rat dentate gyrus after adrenalectomy.
authors.affiliation: Department of Biological Psychiatry, Graduate School for Behavioral, and Cognitive Neurosciences, University of Groningen, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Postigo
authors.forename: Y D
authors.initials: YD
authors.lastname: Van der Werf
authors.forename: J
authors.initials: J
authors.lastname: Korf
authors.forename: H J
authors.initials: HJ
authors.lastname: Krugers
mesh_terms: D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D019938:Cyclin D1 / Q000096:biosynthesis*; D018891:Dentate Gyrus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D016622:Silver Staining
chemical_list: D009419:Nerve Tissue Proteins; D019938:Cyclin D1