Unidirectional transfer of D-xylose across the rat placenta.
1. The transplacental transfer of D-xylose was investigated in the present study. 2. Umbilical perfusion of the rat term placenta was used to study materno-foetal (M-F) and foetomaternal (F-M) transfer of this compound. 3. D-Xylose was found to cross the rat term placenta very quickly in the M-F direction, with subsequent accumulation in the foetal compartment (the F-M ratio being 2.23 at the end of the experiments). In contrast, no transfer in the F-M direction was observed. 4. A possible facilitation of the transplacental transfer of D-xylose from the mother to foetus in rats is suggested.
Staud
F
F
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Heyrovského, Czech Republic. fstaud@pharm.kyoto-u.ac.jp
Fendrich
Z
Z
Karlícek
R
R
Pávek
P
P
D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D005260:Female; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014994:Xylose / Q000493:pharmacokinetics*
D014994:Xylose