Identification of new urinary metabolites of famprofazone in humans.
Urinary metabolites of famprofazone following oral administration in humans were identified by gas chromatography-mass spectrometry with electron impact-ionization and comparison with the spectra and retention times of authentic standards. The metabolites were determined following selective derivatization with N-methyl-bis-trifluoroacetamide (MBTFA) and N-methyl-N-trimethyl silyl trifluoroacetamide (MSTFA). Famprofazone was rapidly and extensively metabolized by N-dealkylation, beta-hydroxylation, and p-hydroxylation. The major metabolite, representing approximately 15% of the dose, was methamphetamine. The other metabolites, which were present in minor amounts, were amphetamine, norephedrine, norpseudoephedrine, ephedrine, pseudoephedrine, p-hydroxyamphetamine, p-hydroxymethamphetamine, and p-hydroxydemethyl famprofazone.
Shin
H S
HS
Department of Environmental Education, Kongju National University, Chungcheungnam-Do, Korea.
Park
B B
BB
Choi
S N
SN
Oh
J J
JJ
Hong
C P
CP
Ryu
H
H
D000081:Acetamides; D000284:Administration, Oral; D000328:Adult; D000661:Amphetamine / Q000652:urine*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000652:urine*; D000697:Central Nervous System Stimulants / Q000652:urine; D005463:Fluoroacetates; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006900:Hydroxylation; D007202:Indicators and Reagents / Q000737:chemistry; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000652:urine*; D010665:Phenylpropanolamine / Q000652:urine; D011720:Pyrazoles / Q000008:administration & dosage / Q000737:chemistry / Q000652:urine*; D047069:Pyrazolones; D014269:Trifluoroacetic Acid / Q000737:chemistry; D014297:Trimethylsilyl Compounds / Q000737:chemistry; D010136:p-Hydroxyamphetamine / Q000652:urine
D000081:Acetamides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000697:Central Nervous System Stimulants; D005463:Fluoroacetates; D007202:Indicators and Reagents; D011720:Pyrazoles; D047069:Pyrazolones; D014297:Trimethylsilyl Compounds; C086665:N-methyl-N-(trimethylsilyl)trifluoroacetamide; C005331:norpseudoephedrine; D010665:Phenylpropanolamine; D008694:Methamphetamine; C005877:pholedrine; D000661:Amphetamine; D014269:Trifluoroacetic Acid; D010136:p-Hydroxyamphetamine; C076013:famprofazone