Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant.
We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasize the importance of the breakpoint at 8p11 and the possible involvement of the MOZ gene in all these cases.
Coulthard
S
S
Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London.
Chase
A
A
Orchard
K
K
Watmore
A
A
Vora
A
A
Goldman
J M
JM
Swirsky
D M
DM
D000208:Acute Disease; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D019457:Chromosome Breakage; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004913:Erythrocytes, Abnormal / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D010587:Phagocytosis / Q000502:physiology*