Rat liver mitochondrial respiratory capacities in the transition from weaning to adulthood.
In the present study we investigated the changes in hepatic mitochondrial function in the transition from weaning to adulthood in the rat. We measured mitochondrial respiration using FAD- and NAD-linked substrates in 25 and 60 day old rats. The results show that adult rats exhibited significantly higher respiratory rates with all the substrates used except pyruvate. Our results indicate that the transition from weaning to adulthood induces important changes in hepatic mitochondrial function.
Iossa
S
S
Department of General and Environmental Physiology, University of Naples Federico II, Italy. susiossa@unina.it
Mollica
M P
MP
Lionetti
L
L
Barletta
A
A
Liverini
G
G
D000375:Aging / Q000378:metabolism*; D000818:Animals; D019069:Cell Respiration; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013379:Substrate Specificity; D013385:Succinate Dehydrogenase / Q000378:metabolism
D009243:NAD; D005182:Flavin-Adenine Dinucleotide; D013385:Succinate Dehydrogenase