title: Evaluation of nickel toxicity on liver, spleen, and kidney of mice after administration of high-dose metal ion.
abstract: The toxic effects caused by nickel (Ni) per si were explored by performing in vivo studies on mice following subcutaneous administration of a metallic solution of nickel at 1, 2, 3, and 4 weeks to evaluate the side effects of this metal ion when released from stainless steel implants. Other groups were similarly injected with HBSS and used as controls. Accumulation of Ni ions on liver, spleen, and kidney was assessed by an electrochemical method, adsorptive stripping voltammetry (AdSV) using microelectrodes, and atomic absorption spectrometry (AAS). Alterations of those organs induced by Ni ions were studied, showing that several histological changes had been induced. Chemical analysis and histological features indicate that Ni is partially accumulated in the study organs.
authors.affiliation: INEB-Instituto de Engenharia Biomédica, Faculdade de Engenharia da Universidade do Porto, Portugal.
authors.forename: M C
authors.initials: MC
authors.lastname: Pereira
authors.forename: M L
authors.initials: ML
authors.lastname: Pereira
authors.forename: J P
authors.initials: JP
authors.lastname: Sousa
mesh_terms: D000818:Animals; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D009532:Nickel / Q000008:administration & dosage / Q000633:toxicity*; D013054:Spectrophotometry, Atomic; D013154:Spleen / Q000187:drug effects* / Q000473:pathology
chemical_list: D009532:Nickel