title: [The action of insulin on cardiac contractility in active, hibernating and arousing susliks Citellus undulatus].
abstract: During the deep hibernation (at 5-6 degrees C of the heart temperature) and during arousal from hibernation (at 15-16 degrees C) insulin have no effect on contractility. Two opposite inotropic effects of insulin at concentrations 0.1-50 nM were found at higher temperature of arousing: a transient positive inotropic effect between 21-28 degrees C, and a negative one (about 20-30% from the control value) above 28 degrees C. In active summer and winter animals insulin produced mainly the negative inotropic effect.
authors.affiliation: Institute of Cell Biophysics, Russian Acad. Sci., Pushchino, Moscow Region.
authors.forename: O V
authors.initials: OV
authors.lastname: Nakipova
authors.forename: R Z
authors.initials: RZ
authors.lastname: Gaĭnullin
authors.forename: V G
authors.initials: VG
authors.lastname: Safronova
authors.forename: L S
authors.initials: LS
authors.lastname: Kosarskiĭ
authors.forename: B F
authors.initials: BF
authors.lastname: Bakaneva
authors.forename: D A
authors.initials: DA
authors.lastname: Ignat'ev
authors.forename: Z G
authors.initials: ZG
authors.lastname: Amerkhanov
authors.forename: S G
authors.initials: SG
authors.lastname: Kolaeva
authors.forename: N I
authors.initials: NI
authors.lastname: Kukushkin
authors.forename: N G
authors.initials: NG
authors.lastname: Solomonov
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology*; D006605:Hibernation / Q000502:physiology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology* / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects*; D012589:Sciuridae / Q000502:physiology*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
vernacular_title: Vliianie insulina na izmenenie napravleniia inotropii sokrashcheniia miokarda giberniruiushchego suslika Citellus undulatus na razlichnykh stadiiakh protsessa probuzhdeniia.