title: Half corneal light shield as a delivery system for standardized application of mitomycin C.
abstract: OBJECTIVE
  The authors develop a simple and economical method of applying reproducible intraoperative doses of mitomycin C for glaucoma filtering surgery.
  
  
  METHODS
  A three-part protocol was developed to study several properties of half corneal light shields (HCLSs). Part A tested the amount of mitomycin C (0.4 mg/ml) absorbed, the expansion dimensions attained, and the amount released to filter paper. In part B, the in vitro release of mitomycin C to an enucleated pig eye was examined. In part C, the in vivo release during intraoperative filtering surgery was tested.
  
  
  RESULTS
  The amount of mitomycin C solution absorbed by the HCLSs ranged from 1.07 x 10(-2) mg to 1.19 x 10(-2) mg; expansion width ranged from 6.8 mm to 7.0 mm; expansion height ranged from 3.6 mm to 3.8 mm; expansion thickness was constant at 0.6 mm. The amount of solution released to filter paper ranged from 6.8 x 10(-3) mg to 8.6 x 10(-3) mg. The amount of solution transferred to the pig eye ranged from 1.0 x 10(-3) mg to 2.7 x 10(-3) mg. The amount of solution released in filtering surgery ranged from 2.0 x 10(-3) mg to 4.8 x 10(-3) mg.
  
  
  CONCLUSIONS
  The contact surface area, the amount absorbed, and the amount released by each HCLS was reproducible. The uniform thickness theoretically provides a uniform distribution of mitomycin C. This method may allow standardization of intraoperative mitomycin C application, and may reduce the incidence of complications.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN 37232-8808, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Khoury
authors.forename: K M
authors.initials: KM
authors.lastname: Joos
authors.forename: J H
authors.initials: JH
authors.lastname: Shen
authors.forename: D
authors.initials: D
authors.lastname: Davis
authors.forename: D M
authors.initials: DM
authors.lastname: O'Day
mesh_terms: D000042:Absorption; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D003315:Cornea / Q000187:drug effects / Q000378:metabolism; D016503:Drug Delivery Systems / Q000592:standards; D018463:Filtering Surgery; D005901:Glaucoma / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007432:Intraoperative Period; D016685:Mitomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D015203:Reproducibility of Results; D013552:Swine
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin