[Associations of HLA class I haplotype antigens with various patterns of keratoconus].
Analysis of deviations in the distribution of HLA antigens and haplotypes characteristic of each of the three patterns of keratocone revealed a genetic predisposition to the development of a certain pattern of the illness. HLA-B27 antigen in the phenotype and increased incidence of haplotypes A2-B27 and A3-B35 were typical of patients with the progressive course of keratocone. In patients with a favorable course of the illness the incidence of HLA-A2 and B15 was the highest. Patients with a history of acute keratocone were characterized by an increased incidence of HLA-A1, A19, B7, and complete absence of HLA-A2. Our findings will help predict the course of keratocone and its relapses presenting as acute keratocone and plan the treatment strategy with due consideration for the immunogenetic features.
Gorskova
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EN
Sevost'ianov
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EN
D000293:Adolescent; D000328:Adult; D002648:Child; D005500:Follow-Up Studies; D005805:Genes, MHC Class I / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D007640:Keratoconus / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D010375:Pedigree
D006680:HLA Antigens
Assotsiatsiia antigenov, gapltipov HLA I klassa s razlichnymi tipami techeniia keratokonusa.