title: [Oxidative modification of monoamine oxidase].
abstract: Oxidative modification of monoamine oxidases (MAO) accompanied by alteration of their substrate specificity and sensitivity to specific inhibitors was discovered by Professor V.Z. Gorkin more than 30 years ago. The mechanism of this phenomenon includes oxidation of SH groups of the enzyme. Oxidative modification of MAO is also accompanied by increased sensitivity to limited proreolysis. Modification of MAO was found in many pathological states, however, elucidation of biological role of this phenomenon requires further investigations.
authors.affiliation: Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Medvedev
authors.forename: K F
authors.initials: KF
authors.lastname: Tipton
mesh_terms: D000818:Animals; D002384:Catalysis; D008995:Monoamine Oxidase / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D013379:Substrate Specificity
chemical_list: D008995:Monoamine Oxidase
vernacular_title: Okislitel'naia modifikatsiia monoaminoksidaz.