Hepatic nodules as single organ involvement in an adult with Langerhans cell granulomatosis. A case report.
Liver involvement manifesting as hepatomegaly in Langerhans cell granulomatosis (LCG) is well known, but the definitive diagnosis is generally possible because other organs are involved. We report a 41-year-old white man who presented with cholestasis and liver nodules as an isolated hepatic LCG. The diagnosis of LCG was suspected based on routine histopathologic examination; the diagnosis became definitive 4 years later when Birbeck granules were found in the liver, an uncommon occurrence in this organ. This is an unusual presentation of a benign form of this disease and one of the first that reported Birbeck granules in the liver.
Lévy
S
S
Department of Hepato-Gastroenterology, Amiens Hospital, France.
Capron
D
D
Joly
J P
JP
Cordonnier
C
C
Sevestre
H
H
Delamarre
J
J
Tribout
B
B
Capron
J P
JP
D000328:Adult; D006529:Hepatomegaly / Q000209:etiology / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications*; D006801:Humans; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D008297:Male; D011859:Radiography; D014463:Ultrasonography