The stimulation of the mitochondrial permeability transition by dihydrolipoate and alpha-lipoate.
The effect of alpha-lipoate and dihydrolipoate on the mitochondrial permeability transition was investigated. Both substances promoted the permeability transition in isolated rat liver mitochondria and in permeabilized hepatocytes, dihydrolipoate most potently in spite of it being a dithiol. The stimulation was prevented by Cyclosporin A or hydroxybutyltoluene but not by ascorbate. It is suggested that the greater potency of dihydrolipoate could be due to formation of a radical.
Saris
N E
NE
Department of Medical Chemistry, University of Helsinki, Finland.
Karjalainen
A
A
Teplova
V V
VV
Lindros
K O
KO
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects*; D010539:Permeability / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D008063:Thioctic Acid; C015144:dihydrolipoic acid; D016572:Cyclosporine