[Antibodies to cardiolipin and hemostasis in rheumatic patients during development of rheumatic valvular disease].
The observational study included 79 rheumatic patients aged 14-49 years. The diagnosis of acute rheumatic fever (ARF) was made in 29 patients (13-first attack, 16-recurrence), 50 patients had rheumatic heart disease (RHD) without signs of activity, 40 healthy donors served control. Antibodies to cardiolipin (a-CL) in the blood were determined by enzyme immunoassay, hemostasis was assessed by the level of antithrombin III, platelet aggregation, readings of electrocoagulograms. ARF patients were examined throughout the year, RHD patients--only once. Compared to the controls, both ARF and RHD patients demonstrated higher occurrence of a-CL, enhanced platelet aggregation, low antithrombin III level, hypercoagulation on electrocoagulogram, a-CL in ARF patients were detectable from the first month of the attack. By month 7-12 their count decreased, hemostasis normalized. In the onset and progression of RHD in the presence of ARF a-CL occurred more frequently. A direct relationship was found between the time of a-CL detection in the blood and severity, duration of rheumatic carditis. The data obtained validate feasibility of using a-CL for diagnosis of rheumatic carditis severity and prognosis of RHD development.
Bobkov
V A
VA
Miasoedova
S E
SE
Lebedeva
A V
AV
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000276:immunology*; D000990:Antithrombin III / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000097:blood / Q000209:etiology / Q000276:immunology*; D006487:Hemostasis / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D011379:Prognosis; D012189:Retrospective Studies; D012214:Rheumatic Heart Disease / Q000097:blood / Q000150:complications / Q000276:immunology*
D017153:Antibodies, Anticardiolipin; D015415:Biomarkers; D000990:Antithrombin III
Antitela k kardiolipinu i pokazateli gemostaza u bol'nykh revmatizmom pri formirovanii revmaticheskikh porokov serdtsa.