title: [Pneumocystosis of splenic localization in the course of HIV infection: a new indication for splenectomy. Description of a case].
abstract: Pneumocystis carinii is a common cause of interstitial pneumonitis in AIDS patients: it affects 85% of patients with cell-mediated immunodeficiencies. Extrapulmonary infection is much more infrequent and it is observed only in these patients who receive aerosolized pentamidine prophylaxis because of minimal systemic distribution of the drug. No case of extrapulmonary disease was observed in patients receiving systemic prophylaxis for Pneumocystis carinii with cotrimoxazole. The pathogenesis of extrapulmonary infection is not clear: it is probably connected with hematogenous or lymphatic dissemination from the lung. In a small number of case is due to reactivation of extrapulmonary foci or to a new infection. The management of disseminated infection of Pneumocystis carinii is medical: only recently a combination of medical and surgical approach was proposed for a patient with extrapulmonary infection. We report a case of 29 years old patient with AIDS with a demonstrated pulmonary and splenic localisation of pneumocystis carinii submitted to surgical splenectomy. The surgical decision was taken for several reasons: no response to medical therapy, the relative good general condition of the patient despite the immunological status, the presence of thrombocytopenia and abdominal pain in the left upper quadrant, and the risk of rupture of spleen. The post-operative course was eventful. We support splenectomy for splenic infection of Pneumocystis carinii in very small selected cases and only with palliative intent.
authors.affiliation: Cattedra di Chirurgia Generale, Ospedale L. Sacco, Università degli Studi di Milano.
authors.forename: A
authors.initials: A
authors.lastname: Galimberti
authors.forename: E
authors.initials: E
authors.lastname: Morandi
authors.forename: G
authors.initials: G
authors.lastname: Giani
authors.forename: P
authors.initials: P
authors.lastname: Vitri
authors.forename: S
authors.initials: S
authors.lastname: Piraneo
authors.forename: L
authors.initials: L
authors.lastname: De Pasquale
authors.forename: A
authors.initials: A
authors.lastname: Bastagli
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy; D008297:Male; D016720:Pneumocystis Infections / Q000188:drug therapy / Q000601:surgery*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy; D013156:Splenectomy; D013158:Splenic Diseases / Q000188:drug therapy / Q000601:surgery*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
vernacular_title: Pneumocistosi a localizzazione splenica in corso di infezione da HIV: una nuova indicazione alla splenectomia. Descrizione di un caso.