Cell kinetic patterns in early gastric cancer.
Early gastric cancers (EGC) may be subdivided into 2 groups by means of the use of mitotic index, apoptotic index and cell density: EGCs with high cell turnover and low cell density, which show high cell dissociation and, more frequently, lymph node invasion; EGCs with low cell turnover and high cell density. The same parameters discriminate among intestinal type tumors, when separately considered from diffuse ones. No correlation is noted of these 2 groups with transforming growth factor-alpha, epidermal growth factor receptor and p53 expression, gross type, entity of neoangiogenesis, and submucosal invasion.
Spina
D
D
Institute of Pathological Anatomy and Histology, University of Siena, Italy.
Miracco
C
C
Vindigni
C
C
Gallorini
M
M
Presenti
L
L
Marrelli
D
D
Roviello
F
F
Pinto
E
E
Filipe
M I
MI
Tosi
P
P
D017209:Apoptosis; D002452:Cell Count; D006801:Humans; D008938:Mitosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D013274:Stomach Neoplasms / Q000473:pathology*
D018809:Proliferating Cell Nuclear Antigen