[Importance of neuromuscular "jitter" under stimulation in the diagnosis of myasthenia gravis].
Ninety five patients with global muscular weakness or purely extraocular weakness were included in a retrospective study. Electrical micro stimulation and single fiber electromyography were performed in all, for neuromuscular jitter evaluation in myasthenia gravis diagnosis. In our study, increased jitter was more often present (70% of generalised myasthenia gravis and 57% of ocular myasthenia gravis) than decrement after repetitive nerve stimulations (58% of generalised myasthenia gravis and 14% of ocular myasthenia gravis). Increased jitter was also found in non-myasthenic patients. With the aim of a better sensitivity and specificity of the electrophysiological diagnosis for myasthenia gravis a protocol is described.
Durand
M C
MC
Service central d'explorations fonctionnelles, hôpital Raymond-Poincaré, Garches, France.
Goulon-Goeau
C
C
Gajdos
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000502:physiology*; D012021:Reflex, Abnormal / Q000502:physiology*; D012189:Retrospective Studies; D009435:Synaptic Transmission / Q000502:physiology*
Intérêt du "jitter" neuromusculaire sous stimulation pour le diagnostic de myasthénie.