[Molecular biological and biochemical features of breast cancer].
Some molecular genetic and biochemical features of malignant breast tumors were studied in females living in North-Western Russia. ERBB-2 oncogene amplification frequently (25%) occurred and was associated with poor outcomes. The frequency of C-MYC extra copies was lower (3%) than that in Europe and the USA. Deletions at chromosome 17p were associated with ERBB-2 amplification and the lack of nodal involvement. Moreover, it is concluded that endogenous hormonal and metabolic parameters, as well their changes due to some environmental factors (smoking), plays a great role in the modification both of breast cancer risk and autocrine-paracrine relationships in the very tumor tissue and of the hormone sensitivity of the latter.
Khanson
K P
KP
Bershteĭn
L M
LM
Imianitov
E N
EN
Tsyrlina
E V
EV
Semiglasov
V F
VF
D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry* / Q000235:genetics* / Q000473:pathology; D002455:Cell Division / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005784:Gene Amplification / Q000235:genetics; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
Molekuliarno-biologicheskie i biokhmicheskie osobennosti raka molochnoĭ zhelezy.