[Testing basic visual functions in the evaluation of extrapyramidal side effects of antipsychotic agents].
One of the cornerstones of antipsychotic therapy is the evaluation of the effective dose that cause minimal extrapyramidal side effects. It is known that the visual system (e. g. the retina) contains dopaminergic cells similarly to the striatum where dopaminergic blockade is crucial in the induction of extrapyramidal symptoms. This rises the possibility that striatal functions can be tested by the evaluation of certain visual functions. This study compared the visual contrast-sensitivity of 20 schizophrenic patients on antipsychotic medication (9 patients were on risperidone, 9 on haloperidol, and 1-1 on zuclopenthixol and fluanxol treatment) to that of normal control subjects, and found significant impairment in the former group. The contrast-sensitivity impairments correlated with the severity of extrapyramidal symptoms. These results suggest that contrast-sensitivity measurements can be useful in the evaluation of neuroleptic threshold in the clinical practice.
Kéri
S
S
Szent-Györgyi Albert Orvostudományi Egyetem Elettani Intézet Szeged, Pszichiátriai Klinika.
Antal
A
A
Szekeres
G
G
Szendi
I
I
Kovács
Z
Z
Janka
Z
Z
Benedek
G
G
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D005116:Extrapyramidal Tracts / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy*; D014786:Vision Disorders / Q000139:chemically induced* / Q000175:diagnosis; D014787:Vision Tests
D014150:Antipsychotic Agents
Elemi vizuális funkciók vizsgálata az antipszichotikumok által elP6dézett extrapyramidalis mellékhatások követésében.