Urinary levels of monocyte chemoattractant protein (MCP)-1 and disease activity in patients with IgA nephropathy.
Using a quantitative sandwich ELISA, we studied 17 patients with IgA nephropathy to determine if levels of urinary monocyte chemoattractant protein-1 (MCP-1) might reflect the disease activity. The levels of urinary MCP-1 in patients with the advanced stage were significantly higher than those in patients with the mild stage of the disease, or in healthy controls. The results showed a significant correlation between the levels of urinary MCP-1 and the disease activity, i.e., levels of urinary casts and urinary protein. It was thus suggested that the measurement of urinary MCP-1 is useful in evaluating the degree of renal injuries and/or prognosis in patients with IgA nephropathy.
Saitoh
A
A
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Suzuki
Y
Y
Takeda
M
M
Kubota
K
K
Itoh
K
K
Tomino
Y
Y
D000328:Adult; D018932:Chemokine CCL2 / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005922:Glomerulonephritis, IGA / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged
D018932:Chemokine CCL2