Biological and molecular characteristics of interleukin-5 and its receptor.
Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders. T cells purified from bronchoalveolar lavage and peripheral blood of asthmatics secrete elevated amount of IL5. Therefore IL5 emerges to be an attractive target for the generation of new anti-allergic drugs. Agents which inhibit either the production or the activity of IL5 could be expected to ameliorate the pathological effects of the allergic response. A better understanding of the biology of IL5 and the regulation of its expression is, however, a prerequisite for the development of new therapeutic agents. This review covers the major biological, molecular and structural aspects of IL5 research since the identification of this cytokine ten years ago.
Karlen
S
S
TVWT Institute for Child Health Research, West Perth, Australia.
De Boer
M L
ML
Lipscombe
R J
RJ
Lutz
W
W
Mordvinov
V A
VA
Sanderson
C J
CJ
D004804:Eosinophils / Q000276:immunology; D006801:Humans; D015848:Interleukin-5 / Q000235:genetics / Q000502:physiology*; D011487:Protein Conformation; D018123:Receptors, Interleukin / Q000235:genetics / Q000502:physiology*; D053649:Receptors, Interleukin-5
D015848:Interleukin-5; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5