title: MS-681a, b, c and d, new inhibitors of myosin light chain kinase from Myrothecium sp. II. Physico-chemical properties and structure elucidation.
abstract: MS-681a, b, c and d are new inhibitors of myosin light chain kinase produced by Myrothecium sp. They are novel octapeptides containing alpha-alkyl-alpha-amino acids and a polyamine moiety. The structures were determined by NMR and FAB-MS/MS spectral analyses of the intact peptides. Their absolute configurations were elucidated by GC analysis on a chiral column of the constituent amino acids and by chemical synthesis of the polyamine moieties.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ikuina
authors.forename: C
authors.initials: C
authors.lastname: Bando
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Yano
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry*; D006999:Hypocreales / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009219:Myosin-Light-Chain Kinase / Q000037:antagonists & inhibitors*; D010455:Peptides / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D013095:Spermidine / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D010455:Peptides; D011073:Polyamines; D009219:Myosin-Light-Chain Kinase; D013095:Spermidine