Effects of extract of oyster on lipid metabolism in rats.
We examined the effects of oyster (Ostrea gingas Thunb.) water extracts on hyperlipemia and liver injury produced in rats by feeding on peroxidized oil. The extracts of oyster were found to reduce the levels of serum free fatty acid, triglyceride, lipid peroxide and liver cholesterol in the peroxidized oil-treated rats. In addition, we found that the water extracts of oyster inhibited adrenaline-induced lipolysis, and that these extracts stimulated lipogenesis from glucose in isolated fat cells of rats. The active substance was isolated and identified as adenosine by direct comparison with an authentic sample.
Kimura
Y
Y
Second Department of Medical Biochemistry, School of Medicine, Ehime University, Japan.
Ohminami
H
H
Okuda
H
H
D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D004837:Epinephrine / Q000494:pharmacology; D006949:Hyperlipidemias / Q000628:therapy; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis / Q000097:blood; D008066:Lipolysis / Q000187:drug effects; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D010125:Ostreidae; D051381:Rats; D017208:Rats, Wistar; D012758:Shellfish; D000637:Transaminases / Q000097:blood
D004042:Dietary Fats, Unsaturated; D008055:Lipids; D000637:Transaminases; D004837:Epinephrine