title: N-arylsubstituted-1-aryl-3,4-diphenyl-5-pyrazole amines with analgesic and antiarrhythmic properties.
abstract: A series of N-aryl substituted-1-aryl-3,4-diphenyl-5-pyrazole amines was synthesized and evaluated for antiinflammatory, antihypertensive and platelet antiaggregating activities. Several of them were found to exhibit a significant analgesic and antiarrhythmic activity.
authors.affiliation: Istituto di Scienze Farmaceutiche dell'Università, Genova.
authors.forename: O
authors.initials: O
authors.lastname: Bruno
authors.forename: S
authors.initials: S
authors.lastname: Schenone
authors.forename: A
authors.initials: A
authors.lastname: Ranise
authors.forename: F
authors.initials: F
authors.lastname: Bondavalli
authors.forename: G
authors.initials: G
authors.lastname: Falcone
authors.forename: W
authors.initials: W
authors.lastname: Filippelli
authors.forename: I
authors.initials: I
authors.lastname: Marabese
authors.forename: G
authors.initials: G
authors.lastname: Motula
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D000588:Amines; D018712:Analgesics, Non-Narcotic; D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D010975:Platelet Aggregation Inhibitors; D011720:Pyrazoles