[Chronic HIV- and chronic HBV infection with hematuria and proteinuria].
METHODS
A medical examination, undertaken in an apparently healthy 30-year-old man because of his occupational exposure to chemicals, revealed haematuria and proteinuria. Physical examination was unremarkable except for oral hair-leukoplakia and swelling of the cervical, supraclavicular, axillary and inguinal lymph nodes.


METHODS
Examination of the urine demonstrated selective glomerular proteins (1.5 g/24 h) and dysmorphic erythrocytes. SGOT and SGPT activities were raised (73 and 129 IU/l, respectively). Active hepatitis B virus (HBV) and human immunodeficiency virus (HIV-1) infections were demonstrated virologically. The CD4+ count in blood was reduced to 200 cells/microliter. Renal biopsy showed an IgA nephropathy.


METHODS
Antiretroviral treatment with zidovudine and lamivudine were started. SGOT and SGPT activities and HIV load fell steadily, while CD4+ cell count rose markedly. Renal functions have remained stable during the past 6 months.


CONCLUSIONS
Signs of glomerular damage are not unusual in systemic diseases, tumors or infections (Hepatitis B and HIV in this case) and they may be the first manifestations of the underlying disease.
von Appen
K
K
Medizinische Kliniken, Klinikum Grosshadern. Kai.vonAppen@lrz.uni-muenchen.de
Beuers
U
U
Mühlhöfer
A
A
Weiss
M
M
Thoenes
G H
GH
Samtleben
W
W
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002908:Chronic Disease; D004784:Environmental Monitoring; D004906:Erythrocyte Count; D015497:HIV-1 / Q000302:isolation & purification*; D015386:Hazardous Substances / Q000009:adverse effects; D006417:Hematuria / Q000209:etiology*; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects; D011507:Proteinuria / Q000209:etiology*; D015215:Zidovudine / Q000627:therapeutic use
D019380:Anti-HIV Agents; D015386:Hazardous Substances; D019259:Lamivudine; D015215:Zidovudine
Chronische HIV- und chronische HBV-Infektion mit Erythrozyturie und Proteinurie.