title: Candida funisitis: A clinicopathologic study of 32 cases.
abstract: We report on 32 cases of Candida funisitis and describe the associated clinicopathologic features. The Candida funisitis was characterized grossly by small, circumscribed, yellow-white nodules on the umbilical cord surface and, microscopically, by subamnionic microabscesses in which fungal organisms were demonstrable. Chorioamnionitis was present in all cases. Twenty-four (75%) of the 32 infants were premature. There were 7 perinatal deaths, all in immature fetuses. Five (16%) of the 32 fetuses had congenital candidiasis. Five (16%) of the mothers had a history of intrauterine foreign body, including intrauterine contraceptive device in three and cervical cerclage in two. The diagnosis of Candida funisitis should prompt a careful examination for fetal infection, even though it is associated with congenital candidiasis in only a minority of the cases.
authors.affiliation: Department of Pathology, Hutzel Hospital, 4707 St. Antoine Boulevard, Detroit, MI 48201, USA.
authors.forename: F
authors.initials: F
authors.lastname: Qureshi
authors.forename: S M
authors.initials: SM
authors.lastname: Jacques
authors.forename: R W
authors.initials: RW
authors.lastname: Bendon
authors.forename: O M
authors.initials: OM
authors.lastname: Faye-Peterson
authors.forename: S A
authors.initials: SA
authors.lastname: Heifetz
authors.forename: R
authors.initials: R
authors.lastname: Redline
authors.forename: C M
authors.initials: CM
authors.lastname: Sander
mesh_terms: D000328:Adult; D002177:Candidiasis / Q000473:pathology*; D005260:Female; D005315:Fetal Diseases / Q000382:microbiology / Q000473:pathology*; D005865:Gestational Age; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000382:microbiology / Q000473:pathology; D010920:Placenta / Q000382:microbiology / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000473:pathology*; D014470:Umbilical Cord / Q000382:microbiology / Q000473:pathology*