title: [Organophosphate poisoning and myocardial necrosis].
abstract: A man (46 years-old) was admitted to the intensive care unit (ICU) with a history that eight hours before he had voluntarily drank 100 ml of malathion. He complained of a burning pain on the anterior thorax and was confused. His cardiovascular evaluation was normal and his breathing was heavy with some rales on the pulmonary auscultation. He was treated with atropine and contrathion and rapidly evolved into coma. Electrocardiogram showed subendocardial lesion in the inferior wall with diffuse ly altered ventricular repolarization and increase QT interval. During the ICU period his cardiac enzyme levels also raised. The patient died in the 8th day after admission. The pathological evaluation of the heart revealed foci of myocardial necrosis. This is the 1st case of medical literature with histological confirmation of myocardial necrosis from organophosphate intoxication.
authors.affiliation: Escola Paulista de Medicina, UNIFESP, São Paulo.
authors.forename: R
authors.initials: R
authors.lastname: Póvoa
authors.forename: S H
authors.initials: SH
authors.lastname: Cardoso
authors.forename: B
authors.initials: B
authors.lastname: Luna Filho
authors.forename: C
authors.initials: C
authors.lastname: Ferreira Filho
authors.forename: M
authors.initials: M
authors.lastname: Ferreira
authors.forename: C
authors.initials: C
authors.lastname: Ferreira
mesh_terms: D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D009946:Organothiophosphorus Compounds
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds
vernacular_title: Intoxicação por órgano-fosforado e necrose miocárdica.