title: Phakomatous choristoma of the eyelid: immunohistochemical observation.
abstract: This article reports the first case of phakomatous choristoma of the eyelid in Japan. The tumor occurred in a 2-week-old boy and was located in the left lower lid near the inner canthus. An immunohistochemical study of this rare, congenital tumor was performed. The immunohistochemical analysis revealed that the epithelial cells of this tumor showed positive staining for vimentin, S-100 protein, and neuron-specific enolase, while they had no immunoreactivity for cytokeratin, glial fibrillary acidic protein, epithelial membrane antigen, or a macrophage marker. Both the epithelial cells and the central contents of the islands in this tumor showed positive staining with anti-human alpha crystallin monoclonal mouse IgG. These results strongly indicated that a phakomatous choristoma was of a lenticular origin.
authors.affiliation: Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kamada
authors.forename: A
authors.initials: A
authors.lastname: Sakata
authors.forename: S
authors.initials: S
authors.lastname: Nakadomari
authors.forename: M
authors.initials: M
authors.lastname: Takehana
mesh_terms: D002828:Choristoma / Q000378:metabolism / Q000473:pathology*; D003459:Crystallins / Q000378:metabolism; D005141:Eyelid Diseases / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D007908:Lens, Crystalline; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D003459:Crystallins; D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase