title: The response of adenoid cystic carcinoma to tamoxifen.
abstract: Adenoid cystic carcinoma of the parotid gland often recurs locally, or metastases develop, after initial treatment with surgery and radiotherapy. We report a patient with an inoperable local recurrence of previously irradiated adenoid cystic carcinoma, who was treated with tamoxifen, an oestrogen receptor antagonist. After 18 months of treatment with tamoxifen, MRI showed a partial response, and further clinical progression of the disease was halted.
authors.affiliation: Royal National Throat, Nose and Ear Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Shadaba
authors.forename: M N
authors.initials: MN
authors.lastname: Gaze
authors.forename: H R
authors.initials: HR
authors.lastname: Grant
mesh_terms: D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D003528:Carcinoma, Adenoid Cystic / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010166:Palliative Care; D010307:Parotid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D016588:Anticarcinogenic Agents; D013629:Tamoxifen