title: Positron emission tomography measurements of pulmonary vascular permeability with Ga-68 transferrin or C-11 methylalbumin.
abstract: OBJECTIVE
  To compare estimates of pulmonary endothelial barrier integrity obtained using two different tracer proteins.
  
  
  METHODS
  Measure the pulmonary transcapillary escape rate with gallium (Ga)-68 labeled transferrin (PTCER(tf)) and positron emission tomography (PET) imaging and compare the results to similar measurements obtained with C-11 labeled methylalbumin (PTCER(alb)).
  
  
  METHODS
  Laboratory investigation.
  
  
  METHODS
  Mongrel dogs.
  
  
  METHODS
  No intervention in one group of dogs (n = 3); oleic-acid induced lung injury in another set (n = 4).
  
  
  RESULTS
  Although PTCER(tf) was consistently higher than PTCER(alb) (mean difference: 50 x 10(-4)/min), the overall correlation between the two methods, after normalizing for differences in regression slope and intercept among the individual dogs, was excellent (r2 = .67).
  
  
  CONCLUSIONS
  The data support the continued use of PET and Ga-68 transferrin as an appropriate means of evaluating and quantifying lung injury.
authors.affiliation: Department of Internal Medicine, the Institute for Biomedical Computing, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Schuster
authors.forename: J
authors.initials: J
authors.lastname: Markham
authors.forename: M J
authors.initials: MJ
authors.lastname: Welch
mesh_terms: D000418:Albumins; D000818:Animals; D002199:Capillary Permeability; D002250:Carbon Radioisotopes; D004285:Dogs; D005710:Gallium Radioisotopes; D008168:Lung / Q000098:blood supply* / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed; D014168:Transferrin
chemical_list: D000418:Albumins; D002250:Carbon Radioisotopes; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D014168:Transferrin