title: CD4+/CD45RA+ 'naive' T cells and immunological response to influenza virus vaccine in B-cell chronic lymphocytic leukaemia patients.
abstract: B-cell chronic lymphocytic leukaemia (B-CLL) is characterized by a high frequency of infections, including those of viral aetiology. Previous reports have demonstrated a specific immunologic response to influenza virus vaccine in B-CLL patients with normal IgG levels. In this study, we have evaluated different immunophenotypically defined B and T cell subsets in 18 B-CLL patients before immunization with killed-influenza-virus vaccine. A correlation between immunological response to vaccination and both absolute numbers of CD4+/CD45RA+ naive T cells and CD5- B cells was found. These data may suggest a supporting role of the CD4+/CD45RA+ T cell subset in the specific antibody response to vaccination with influenza virus vaccine in B-CLL patients.
authors.affiliation: Cattedra e Divisione di Ematologia, Universitá degli Studi, Siena, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Marotta
authors.forename: A
authors.initials: A
authors.lastname: Bucalossi
authors.forename: P
authors.initials: P
authors.lastname: Galieni
authors.forename: C
authors.initials: C
authors.lastname: Bigazzi
authors.forename: S
authors.initials: S
authors.lastname: Nuti
authors.forename: P E
authors.initials: PE
authors.lastname: Valenzin
authors.forename: M
authors.initials: M
authors.lastname: Bocchia
authors.forename: F
authors.initials: F
authors.lastname: Lauria
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000096:biosynthesis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D007252:Influenza Vaccines / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology* / Q000473:pathology; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D017493:Leukocyte Common Antigens