title: Habitual snorers and sleep apnoics have abnormal vascular reactions of the soft palatal mucosa on afferent nerve stimulation.
abstract: A local disturbance in the afferent nerves involved in the reflexogenic dilation of the upper airways (UAs) could contribute to the increased collapsibility seen in patients with obstructive sleep apnea (OSA). Laser Doppler perfusion monitoring, combined with electrical stimulation, is a method for investigating the afferent nerve regulation of the microcirculation. It was used in the mucosa of the soft palate in 35 patients with various degrees of UA obstruction and in 13 control subjects, all nonsmoking men. In a majority of snorers and patients with mild OSA, stimulation induced an exaggerated vasodilation, compared with controls. In contrast, in patients with severe OSA, the vasodilation was significantly reduced, compared with controls. These signs of disturbances in the microcirculation support the hypothesis of a local progressive afferent nerve lesion in heavy snorers with or without OSA.
authors.affiliation: Department of Otorhinolaryngology, Söder Hospital, Karolinska Institute, Stockholm, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Friberg
authors.forename: B
authors.initials: B
authors.lastname: Gazelius
authors.forename: L E
authors.initials: LE
authors.lastname: Lindblad
authors.forename: B
authors.initials: B
authors.lastname: Nordlander
mesh_terms: D000328:Adult; D000344:Afferent Pathways; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004558:Electric Stimulation; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation / Q000294:innervation; D008875:Middle Aged; D009061:Mouth Mucosa / Q000098:blood supply*; D010160:Palate, Soft / Q000098:blood supply* / Q000294:innervation; D017933:Peripheral Nervous System; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D012913:Snoring / Q000503:physiopathology*; D014664:Vasodilation