title: A case of canine central nervous system cryptococcosis: management with fluconazole.
abstract: A three-year-old, female Labrador retriever was presented for acute generalized seizures. Disseminated cryptococcosis with central nervous system (CNS) involvement was diagnosed by serum and cerebrospinal fluid (CSF) fungal titers, histopathological examination, and magnetic resonance imaging (MRI). Fluconazole therapy resulted in prolonged, substantial clinical improvement for a period of one year. This report documents the diagnosis of a case of cryptococcal meningoencephalitis and its management with the new antifungal agent, fluconazole.
authors.affiliation: Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: D
authors.initials: D
authors.lastname: Tiches
authors.forename: C H
authors.initials: CH
authors.lastname: Vite
authors.forename: B
authors.initials: B
authors.lastname: Dayrell-Hart
authors.forename: S A
authors.initials: SA
authors.lastname: Steinberg
authors.forename: S
authors.initials: S
authors.lastname: Gross
authors.forename: F
authors.initials: F
authors.lastname: Lexa
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D002490:Central Nervous System / Q000382:microbiology* / Q000473:pathology; D003453:Cryptococcosis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D015725:Fluconazole / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008590:Meningoencephalitis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D011859:Radiography; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole