title: Specific antibody to Cryptococcus neoformans alters human leukocyte cytokine synthesis and promotes T-cell proliferation.
abstract: Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.
authors.affiliation: Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy. vecchiar@unipg.it
authors.forename: A
authors.initials: A
authors.lastname: Vecchiarelli
authors.forename: C
authors.initials: C
authors.lastname: Retini
authors.forename: C
authors.initials: C
authors.lastname: Monari
authors.forename: A
authors.initials: A
authors.lastname: Casadevall
mesh_terms: D000908:Antibodies, Fungal / Q000097:blood*; D003455:Cryptococcus neoformans / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D000908:Antibodies, Fungal; D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha