Analysis of FcgammaRII gene polymorphisms in Wegener's granulomatosis.
Fcgamma receptors (FcgammaRs) are potent initiators of proinflammatory reactions and tissue injury programs through the oxidative burst, degranulation and the production of a variety of proinflammatory cytokines. Direct experimental evidence indicates that translocation of ANCA target from intracellular granules to the neutrophil membrane and subsequent binding of ANCA enables FcgammaR-mediated neutrophil activation. In the presence of ANCA, these data provide a framework from which to understand the importance of ANCA class, subclass, and titer in Wegener's granulomatosis and other ANCA-positive vasculitides. The well-characterized and functionally important alleles of neutrophil FcgammaR (FcgammaRIIa-H131/R131 and FcgammaRIIIb-NA1/NA2) are possible inheritable genetic elements that may alter disease severity and/or phenotype.
Edberg
J C
JC
Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 35294-0006, USA.
Wainstein
E
E
Wu
J
J
Csernok
E
E
Sneller
M C
MC
Hoffman
G S
GS
Keystone
E C
EC
Gross
W L
WL
Kimberly
R P
RP
D000483:Alleles; D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology; D014890:Granulomatosis with Polyangiitis / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics* / Q000276:immunology
D015703:Antigens, CD; C080568:Fc gamma receptor IIA; D007074:Immunoglobulin G; D017452:Receptors, IgG