Roseocardin, a novel cardiotonic cyclodepsipeptide from Trichothecium roseum TT103.
A new cyclodepsipeptide, designated roseocardin, was isolated from the culture broth of Trichothecium roseum TT103. Roseotoxin B and destruxins A and B were also isolated during the same procedure. The structure of roseocardin was determined by EI-MS, NMR and X-ray crystallographic analysis. Roseocardin as well as the other cyclodepsipeptides were shown to produce positive inotropic effects on rat heart muscles.
Tsunoo
A
A
Meiji Institute of Health Science, Meiji Milk Products Co., Ltd., Kanagawa, Japan.
Kamijo
M
M
Taketomo
N
N
Sato
Y
Y
Ajisaka
K
K
D000818:Animals; D002316:Cardiotonic Agents / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D047630:Depsipeptides; D006321:Heart / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D003904:Mitosporic Fungi / Q000737:chemistry*; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D002316:Cardiotonic Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C111135:roseocardin; C040423:destruxin A; C010324:roseotoxin B