Brain derived neurotrophic factor is increased in cerebrospinal fluid of children suffering from asphyxia.
Brain derived neurotrophic factor (BDNF) is a neurotrophic factor that is relatively highly expressed in developing and adult brain. Whereas clinical determinations of nerve growth factor (NGF) in human serum and cerebrospinal fluid (CSF) in different conditions have been undertaken there are no reports on levels of BDNF in human CSF. Here we show that BDNF is increased in CSF of neonatal children suffering from asphyxia which is characterised by periods of brain hypoxic-ischemia. In contrast to BDNF, levels of CSF NGF were largely decreased in these children. The present results show that BDNF can be detected in human CSF and that the levels increase following hypoxic-ischemic brain injury. As suggested by animal studies the increased BDNF might counteract neuronal damage observed in these patients following asphyxia.
Korhonen
L
L
Department of Developmental Neuroscience, Biomedical Centre, Uppsala, Sweden.
Riikonen
R
R
Nawa
H
H
Lindholm
D
D
D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000134:cerebrospinal fluid*; D001930:Brain Injuries / Q000134:cerebrospinal fluid; D002545:Brain Ischemia / Q000134:cerebrospinal fluid; D019208:Brain-Derived Neurotrophic Factor / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors