title: Complications associated with high-dose prednisolone sodium succinate therapy in dogs with neurological injury.
abstract: A retrospective study of 105 dogs with neurological injury was conducted to evaluate the type and prevalence of complications encountered when treatment consisted of a high-dose corticosteroid protocol. All dogs were treated with high-dose prednisolone sodium succinate (HDPSS) (30 mg/kg body weight, administered intravenously [i.v.] q 6 hrs for 36 hrs). Thirty-five (33.3%) cases developed complications including diarrhea (n = 11), melena (n = 11), vomiting (n = 6), hematochezia (n = 3), hematemesis (n = 1), anorexia (n = 1), or a combination (n = 2). Most complications resolved without additional treatments after termination of the HDPSS therapy. None of the complications were considered serious, and none prolonged hospitalization.
authors.affiliation: Department of Surgery, Animal Medical Center, New York, New York, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Culbert
authors.forename: D J
authors.initials: DJ
authors.lastname: Marino
authors.forename: R M
authors.initials: RM
authors.lastname: Baule
authors.forename: V W
authors.initials: VW
authors.lastname: Knox
mesh_terms: D000818:Animals; D000855:Anorexia / Q000139:chemically induced / Q000662:veterinary; D002490:Central Nervous System / Q000293:injuries*; D003967:Diarrhea / Q000139:chemically induced / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000662:veterinary; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006396:Hematemesis / Q000139:chemically induced / Q000662:veterinary; D008551:Melena / Q000139:chemically induced / Q000662:veterinary; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D014839:Vomiting / Q000139:chemically induced / Q000662:veterinary
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone