title: [Treatment of patients for chronic pulmonary tuberculosis with expectoration--selection and tolerance to drugs].
abstract: In retrospective analysis of 48 patients with chronic pulmonary tuberculosis we concluded that in spite of increasing drug resistance to first line drugs only 52% chronics received other than first line antituberculous drugs. Our treatment was based on the selection of drugs according to susceptibility tests. 4-6 drugs were used at the beginning of treatment. 13 patient were excluded of the group. Of remaining 35 chronics sputum conversion was achieved in 30 cases (85.7%). Our successful treatment of patients with chronic tuberculosis was based on the following principles: treatment with other than first line antituberculous drugs and treatment with the combination of 5 or 6 drugs selected on susceptibility tests in the initial phase continuing with 2-3 drugs for 12-18 months after sputum conversion. Ofloxacin improves the efficacy of regimens used for treatment of chronic tuberculosis.
authors.affiliation: I Kliniki Gruźlicy i Chorób Płuc.
authors.forename: D
authors.initials: D
authors.lastname: Michałowska-Mitczuk
authors.forename: J
authors.initials: J
authors.lastname: Kuś
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D006801:Humans; D015994:Incidence; D015242:Ofloxacin / Q000008:administration & dosage; D012189:Retrospective Studies; D013183:Sputum / Q000382:microbiology; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D015242:Ofloxacin
vernacular_title: Leczenie chorych na gruźlice płuc przewlekle pratkujacych--dobór i tolerancja leków.