title: Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria.
abstract: Quinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg) were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were similar to those reported previously for the 2 compounds given individually to a similar group of patients. Although postural hypotension was common (6 cases before treatment and 7 after) and the electrocardiogram QTc interval was prolonged by a mean of 12% (SD = 8) following drug treatment, there was no evidence of a clinically significant cardiovascular pharmacodynamic interaction between these 2 structurally related antimalarial compounds.
authors.affiliation: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: W
authors.initials: W
authors.lastname: Supanaranond
authors.forename: Y
authors.initials: Y
authors.lastname: Suputtamongkol
authors.forename: T M
authors.initials: TM
authors.lastname: Davis
authors.forename: S
authors.initials: S
authors.lastname: Pukrittayakamee
authors.forename: P
authors.initials: P
authors.lastname: Teja-Isavadharm
authors.forename: H K
authors.initials: HK
authors.lastname: Webster
authors.forename: N J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000188:drug therapy*; D015767:Mefloquine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D011803:Quinine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D011803:Quinine; D015767:Mefloquine