title: Carboplatin and vinorelbine in the treatment of advanced non-small-cell lung cancer: a multicenter phase II study.
abstract: The aim of this study was to identify a chemotherapy combination that would be active and well tolerated for palliative treatment of advanced non-small-cell lung cancer (NSCLC). From February 1992 to December 1994, a total of 77 patients affected by stage-IIIB and stage-IV NSCLC were treated with carboplatin 350 mg/m2 on day 1 and vinorelbine 25 mg/m2 on days 1 and 8 of each cycle, with cycles repeated every 28 days. All patients were evaluable for response and toxicity. A total of 24 patients showed a partial response (31% response rate; 95% CI = 21-41%). The median duration of overall survival was 41 weeks (95% CI = 31-51), and the median time to disease progression was 34 weeks (95% CI = 25-43). The treatment was well tolerated: no grade-4 toxicity was observed. The carboplatin-vinorelbine combination deserves to considered as a valid alternative to regimens that include cisplatin for palliative treatment of advanced NSCLC.
authors.affiliation: Department of Pneumology, Azienda Ospedaliera Careggi, Florence, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Santomaggio
authors.forename: E
authors.initials: E
authors.lastname: Tucci
authors.forename: M
authors.initials: M
authors.lastname: Rinaldini
authors.forename: R
authors.initials: R
authors.lastname: Algeri
authors.forename: R
authors.initials: R
authors.lastname: Righi
authors.forename: F
authors.initials: F
authors.lastname: Pepi
authors.forename: P
authors.initials: P
authors.lastname: Ghezzi
authors.forename: A
authors.initials: A
authors.lastname: Andrei
authors.forename: A
authors.initials: A
authors.lastname: Bellezza
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D016190:Carboplatin; D000077235:Vinorelbine