[Bone metabolism and phosphorus metabolism in patients with prostate cancer: paracrine and endocrine effects produced by prostate neoplasm].
We examined whether paracrine factors produced by prostate cancer cells can modulate bone metabolism in proportion to the volume of cancer cells in bone metastasis. Endocrine factors produced by prostate cancer cells affect both phosphate and 1,25-dihydroxyvitamin D metabolisms. Levels of urine pyridinoline (U-Pyr) excretion and serum carboxy-terminal propeptide of type 1 procollagen (P1CP) in patients with bone metastasis were significantly higher than those in patients without bone metastasis (P < 0.05). In patients with bone metastasis (n = 17), serum prostate-specific antigen (PSA) levels were significantly correlated with the levels of U-Pyr and urine deoxypyridinoline (U-dPyr) excretion, serum cross-linked carboxyterminal telopeptide of type 1 collagen (1CTP), and P1CP levels (p < 0.05). However, serum PSA levels were not correlated with U-Pyr, U-dPyr excretions, serum 1CTP and P1CP levels in patients without bone metastasis. Therefore, prostate cancer cells appear to have some paracrine effects on bone cells. In controls (n = 15), serum 1,25-dihydroxyvitamin D levels (1,25-(OH)2D) were inversely correlated with serum phosphorus levels (P < 0.01). In prostate cancer patients with bone metastasis, the ability to regulate the serum 1,25-(OH)2D levels in response to serum phosphorus levels is lost. These results suggest that endocrine factors produced by prostate cancer cells disturb the regulation of serum 1,25-(OH)2D in response to serum phosphorus levels.
Satani
H
H
Department of Urology, Mie University School of Medicine.
Yamakawa
K
K
Kawamura
J
J
Mori
O
O
Saito
K
K
Kato
H
H
Tochigi
H
H
Sakurai
M
M
Kato
T
T
D000368:Aged; D000596:Amino Acids / Q000652:urine; D014408:Biomarkers, Tumor / Q000378:metabolism; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary*; D001842:Bone and Bones / Q000378:metabolism*; D006801:Humans; D008297:Male; D019899:Paracrine Communication; D010446:Peptide Fragments / Q000097:blood; D010758:Phosphorus / Q000378:metabolism*; D011347:Procollagen / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000378:metabolism
D000596:Amino Acids; D014408:Biomarkers, Tumor; D010446:Peptide Fragments; D011347:Procollagen; C042813:procollagen type I carboxy terminal peptide; D014807:Vitamin D; D010758:Phosphorus; C015484:pyridinoline; C097949:1,25-dihydroxyvitamin D; C036020:deoxypyridinoline; D017430:Prostate-Specific Antigen