title: The slow axonal transport of cytoskeletal proteins.
abstract: Once presumed to be relatively uniform, the axonal cytoskeleton can vary markedly in size and composition along its length. New studies emphasize the interactiveness of neurofilaments and identify a family of cytoskeletal proteins that may cross-link the various cytoskeletal polymers of the axon, and anchor this network to the membrane skeleton. These and other findings support a model of the axonal cytoskeleton as a stationary but dynamic structure. Current evidence continues to support the possibility that axonally transported polymers/oligomers and/or monomers may serve as precursors to the cytoskeleton in different situations. Although the motors for slow transport of cytoskeletal proteins remain elusive, possible candidates are emerging.
authors.affiliation: Nathan Kline Institute for Psychiatric Research, New York University Medical Center, Orangeburg 10962, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Nixon
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism
chemical_list: D003598:Cytoskeletal Proteins