Folate and coronary heart disease.
Low folate intake is an important determinant of elevated blood levels of homocysteine. Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD. The magnitude of the association between folate and CHD is consistent with its effects on homocysteine.
Verhoef
P
P
Division of Human Nutrition and Epidemiology, Agricultural University, Wageningen, The Netherlands.
Stampfer
M J
MJ
Rimm
E B
EB
D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2); D003327:Coronary Disease / Q000097:blood*; D005492:Folic Acid / Q000008:administration & dosage* / Q000378:metabolism; D006710:Homocysteine / Q000097:blood; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D018673:Nutrition Policy; D010088:Oxidoreductases / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors
D006710:Homocysteine; D005492:Folic Acid; D010088:Oxidoreductases; D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2); D042965:Methylenetetrahydrofolate Reductase (NADPH2)