Transcription: TRF walks the walk but can it talk the talk?
The TBP-related factor TRF binds to a TATA box promoter sequence and mediates basal transcription in vitro. A central question is: does TRF function in vivo to transduce the effects of activators in a tissue-specific fashion?
Hori
R
R
Department of Biological Chemistry, UCLA School of Medicine 90095-1737, USA.
Carey
M
M
D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D035182:TATA Box Binding Protein-Like Proteins; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D035182:TATA Box Binding Protein-Like Proteins; C441409:TBPL1 protein, human; D014157:Transcription Factors