title: Lack of cardiac manifestations among patients with previously treated Lyme disease.
abstract: BACKGROUND
  Cardiac involvement is common in acute Lyme disease, and case reports suggest that cardiac abnormalities might also occur years after the primary infection.
  
  
  OBJECTIVE
  To determine the prevalence of cardiac abnormalities in persons with previously treated Lyme disease.
  
  
  METHODS
  Population-based, retrospective cohort study with controls.
  
  
  METHODS
  Nantucket Island, Massachusetts.
  
  
  METHODS
  From among 3703 adult respondents to a total-population (n = 6046) mail survey, 336 (176 case-patients and 160 controls) were randomly selected for clinical evaluation.
  
  
  METHODS
  Current cardiac symptoms and major or minor abnormal electrocardiographic features, including heart rate; rhythm; axis; PR, QRS, and QT intervals; QRS structure; atrioventricular blocks; and ST-segment and T-wave changes.
  
  
  RESULTS
  Persons with Lyme disease (case-patients, n = 176) (mean duration from disease onset to study evaluation, 5.2 years) and persons without evidence of previous Lyme disease (controls, n = 160) did not differ significantly in their patterns of current cardiac symptoms and electrocardiographic findings, including heart rate (P > 0.2), PR interval (P = 0.15), QRS interval (P > 0.2), QT interval (P > 0.2), axis (P > 0.2), presence of arrhythmias (P > 0.2), first-degree heart block (P = 0.12), bundle-branch block (P > 0.2), and ST-segment abnormalities (P > 0.2). In multivariate analyses that adjusted for age, sex, and previous heart disease, a history of previously treated Lyme disease was not associated with either major (odds ratio, 0.78; P > 0.2) or minor (odds ratio, 1.09; P > 0.2) electrocardiographic abnormalities.
  
  
  CONCLUSIONS
  Persons with a history of previously treated Lyme disease do not have a higher prevalence of cardiac abnormalities than persons without a history of Lyme disease.
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: O
authors.initials: O
authors.lastname: Sangha
authors.forename: C B
authors.initials: CB
authors.lastname: Phillips
authors.forename: K E
authors.initials: KE
authors.lastname: Fleischmann
authors.forename: T J
authors.initials: TJ
authors.lastname: Wang
authors.forename: A H
authors.initials: AH
authors.lastname: Fossel
authors.forename: R
authors.initials: R
authors.lastname: Lew
authors.forename: M H
authors.initials: MH
authors.lastname: Liang
authors.forename: N A
authors.initials: NA
authors.lastname: Shadick
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008193:Lyme Disease / Q000150:complications*; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013223:Statistics as Topic