Recurrent chromosome changes in two adult fibrosarcomas.
Cytogenetic analysis of two adult fibrosarcomas revealed clonal chromosomal rearrangements including unbalanced translocations between chromosomes 2 and 19, with the same segment, 2q21-qter, translocated onto 19p13 in one tumor and 19q13 in another; and partial monosomy of 10q due to add(10)(q22) and del(10)(q22q25) seen in one tumor each. This is the first description of nonrandom chromosomal changes in adult fibrosarcoma.
Limon
J
J
Department of Biology and Genetics, Medical University of Gdańsk, Poland. katgen@amed01.amg.gda.pl
Szadowska
A
A
Iliszko
M
M
Babińska
M
M
Mrózek
K
K
Jaśkiewicz
J
J
Kopacz
A
A
Roszkiewicz
A
A
Debiec-Rychter
M
M
D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics* / Q000473:pathology; D025063:Chromosome Disorders; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D005354:Fibrosarcoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D019042:Muscle Neoplasms / Q000235:genetics* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*