[The delta sleep-inducing peptide, its analogs and the serotoninergic system in the development of anticonvulsant action].
A seizure-protecting effect of the delta-sleep-inducing peptide (DSIP) and its analogues was revealed. An intensive sorption of H3 tryptophan occurred under the effect of the DSIP and its analogues. The data obtained suggests that the serotoninergic system plays no important part in the seizure-protecting effect.
Shandra
A A
AA
State Medical University, Odessa, Ukraine.
Godlevskiĭ
L S
LS
Brusentsov
A I
AI
Petrashevich
V P
VP
Vast'ianov
R S
RS
Nickel
B
B
Mikhaleva
I I
II
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D003292:Convulsants; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000188:drug therapy; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D007608:Kainic Acid; D008297:Male; D010852:Picrotoxin; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology; D014316:Tritium; D014364:Tryptophan / Q000378:metabolism
D000927:Anticonvulsants; D003292:Convulsants; D003701:Delta Sleep-Inducing Peptide; D007608:Kainic Acid; D010852:Picrotoxin; D011985:Receptors, Serotonin; D014316:Tritium; D014364:Tryptophan
Del'ta-son indutsiruiushchiĭ peptid, ego analogi i serotoninergicheskaia sistema v razvitii protivosudorozhnogo deĭstviia.