Analysis of urinary 11-dehydrothromboxane B2 in patients with occluded retinal vein using GC/SIM.
We describe variations of 11-dehydrothromboxane B2(11-dehydro-TXB2) levels in human urine samples. Retinal vein occlusion (RVO) is a thrombotic disease in which the retinal vein is blocked by blood aggregations. We considered the possibility that 11-dehydro-TXB2 plays an important role in the formation of RVO. Thus, we determined the 11-dehydro-TXB2 levels in patients with RVO using gas chromatography/selected ion monitoring (GC/SIM) and compared them with those of healthy volunteers. The thromboxane levels in patients with RVO, who did not also have diabetes, were significantly higher than those in healthy volunteers. One cause of RVO may be the variation of thromboxane production. Furthermore, this GC/SIM method can be applied to the prevention and treatment of not only RVO, but also of general thrombosis.
Yamanobe
S
S
Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
Nakagawa
Y
Y
Hishinuma
T
T
Mizugaki
M
M
Tamai
M
M
D000328:Adult; D000368:Aged; D002849:Chromatography, Gas / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000209:etiology* / Q000473:pathology; D013927:Thrombosis / Q000209:etiology / Q000473:pathology; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine
D013929:Thromboxane B2; C049235:11-dehydro-thromboxane B2