[Cytopathogenic bovine viral diarrhea viruses induce apoptosis in bovine cell cultures].
The pestivirus bovine viral diarrhea (BVD) virus is the causative agent of Mucosal Disease (MD) of cattle. From persistently infected animals, only the non-cytopathogenic biotype BVD virus can be isolated. Cattle succumbing to MD additionally harbour cytopathogenic BVD virus. While cp BVD virus isolates induce a cytopathic effect (cpe) in susceptible monolayer cell cultures, infection with ncp BVD virus isolates has no visible effect. The purpose of this study was to investigate the correlation between cpe and apoptosis.
Grummer
B
B
Institut für Virologie, Tierärztliche Hochschule Hannover.
Moennig
V
V
Greiser-Wilke
I
I
D000818:Animals; D017209:Apoptosis; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000821:virology*; D002417:Cattle; D002478:Cells, Cultured; D005333:Fetus; D007668:Kidney / Q000166:cytology / Q000502:physiology / Q000821:virology; D010576:Pestivirus / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D014774:Virulence
Zytopathogene Bovine Virusdiarrhoe Viren induzieren Apoptose in infizierten Rinderzellkulturen.