The effects of bone resorption inhibitors on the growth plate and proximal tibial metaphysis of rats: clinical implications.
This study investigated the effects of diphosphonates at scalar doses in a high bone turnover structure, namely, the proximal tibial metaphysis of rats. Arrest of bone modeling was represented by cylindrical-shaped metaphyses, increased height of the perichondrial bone bark, and persistence of primary metaphyseal trabeculae; these changes were dose-related. Higher doses of the inhibitors produced extension of the growth plate and arrest of the mineralization process. The dose-related dissociation between the effects on bone resorption and mineralization allows the therapeutic use of this class of drugs.
Pazzaglia
U E
UE
Clinica Ortopedica 2a Facolta' di Medicina e Chirurgia, Universita' di Pavia, Varese, Italy.
Andrini
L
L
Leutner
M
M
Di Nucci
A
A
D000818:Animals; D001862:Bone Resorption; D002116:Calcitonin / Q000494:pharmacology*; D004164:Diphosphonates / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D006132:Growth Plate / Q000187:drug effects* / Q000473:pathology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000187:drug effects* / Q000473:pathology / Q000502:physiology
D004164:Diphosphonates; D002116:Calcitonin