[No association between IgG anti-GTla antibody and bulbar palsy in Guillain-Barré and Fisher's syndromes].
Pharyngeal-cervical-brachial weakness (PCB) is a rare variant of Guillain-Barré syndrome (GBS) and shows a regional muscle weakness, specially in oropharynx. Mizoguchi et al. (1994) reported a GBS patient with PCB-like symptoms who had serum IgG anti-GTla antibodies in the acute phase of illness. We therefore assumed that bulbar palsy was associated with anti-GTla antibodies and made serological study in patients with GBS or Fisher's syndrome. The frequency of positive IgG anti-GTla antibody was significantly higher in patients with bulbar palsy than those without bulbar palsy. Most of the patients with IgG anti-GTla antibodies, however, had also anti-GQlb antibodies in their sera and anti-GTla antibodies were more closely associated with ophthalmoplegia than with bulbar palsy. These findings do not support that IgG anti-GTla antibodies play an important role in the pathogenesis of bulbar palsy in GBS.
Koga
M
M
Department of Neurology, Dokkyo University School of Medicine.
Yuki
N
N
Hirata
K
K
D001323:Autoantibodies / Q000032:analysis*; D010244:Bulbar Palsy, Progressive / Q000209:etiology*; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D019846:Miller Fisher Syndrome / Q000150:complications* / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000150:complications* / Q000276:immunology* / Q000503:physiopathology
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; C016481:trisialoganglioside GT1