[Combined effect of hypokinesia of various duration and gamma-radiation on central nervous system activity in rats].
There studied the effects of a combined effect of hypokinesia (HK) of various duration (7 and 30 days, corresponding to the stages of anxiety and resistance of general adaptation syndrome) and gamma-radiation dose of 3 Gy on the formation of differentiated motor-drinking conditioned reflex (CR) in the rats. It is demonstrated that the applied exposures lead to the various disorders of the higher nervous activity of the test animals: after 7-day hypokinesia in the behaviour there prevail the fear and emotional-vegetative components whereas following 30-day hypokinetic exposure there occurs some stimulation of the orientation-exploratory behaviour with concurrent enhancement of the inertness of nervous processes and the tendency to formation of stringent behavioural stereotypes slowing-down the conditioned reflex formation. A modifying effect of radiation counts only after 30-day hypokinesia and consists in the development of extra-limited inhibition (reaction of acquired helplessness) in the part of animals.
Shtemberg
A S
AS
State Research Center "Institute of Medical Biological Problems", RF.
D000818:Animals; D001522:Behavior, Animal / Q000528:radiation effects*; D002490:Central Nervous System / Q000502:physiology* / Q000528:radiation effects; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D018476:Hypokinesia / Q000503:physiopathology*; D008297:Male; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar
Kombinirovannoe deístvie gipokinezii raznoí prodolzhitel'nosti i gamma-oblucheniia na vysshuiu nervnuiu deiatel'nost' krys.