title: Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease.
abstract: The function of the cytokine interleukin-6 (IL-6) is augmented by soluble IL-6 receptors (sIL-6R). We investigated cerebrospinal fluid sIL-6R concentrations in patients with Alzheimer's disease (AD) compared to age-matched healthy subjects and individuals with at least one first degree relative with AD. We found a statistically significant decrease in sIL-6R levels in the AD group compared to controls. Complete analysis of the IL-6R complex seems crucial to better understand the impact of IL-6 in AD pathophysiology.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilian University Munich, School of Medicine, Germany. hampel@psy.med.uni.muenchen.de
authors.forename: H
authors.initials: H
authors.lastname: Hampel
authors.forename: T
authors.initials: T
authors.lastname: Sunderland
authors.forename: H U
authors.initials: HU
authors.lastname: Kötter
authors.forename: C
authors.initials: C
authors.lastname: Schneider
authors.forename: S J
authors.initials: SJ
authors.lastname: Teipel
authors.forename: F
authors.initials: F
authors.lastname: Padberg
authors.forename: R
authors.initials: R
authors.lastname: Dukoff
authors.forename: J
authors.initials: J
authors.lastname: Levy
authors.forename: H J
authors.initials: HJ
authors.lastname: Möller
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019947:Receptors, Interleukin-6 / Q000378:metabolism*; D012044:Regression Analysis; D012995:Solubility
chemical_list: D019947:Receptors, Interleukin-6