[Correlation of changes in bone marrow cell sensitivity to the clastogenic effect of thiotepa and fertility in CBA/LacY mice in successive inbred generations].
The causes of the significant increases in the sensitivity to of clastogenic effect of thio-TEPA in bone marrow cells of inbred CBA/LacY mice were studied. The increases were shown to be associated with decreased fertility. The fluctuations of fertility and the association of fertility and sensitivity with thio-TEPA were analyzed in foundation stocks (FSs) for 24 and 6 inbred generations, respectively. The stocks examined were obtained in the Laboratory of Experimental Biological Models and the Stolbovaya breeding facility. The correlation analysis revealed a significant association of fluctuations of the coefficient of fertility in two FSs (eta = 0.78 +/- 0.13) and a high negative correlation between fertility and mutagen sensitivity in inbred generations (r = -0.91 +/- 0.21). The comparison between the fluctuations of fertility for four generations revealed the same fluctuation period in CBA/LacY, DBA/2Y, and C57Bl/6JY mice. The detected phenomena were assumed to result from genetically determined regular fluctuations in genome functioning. This explained a number of observations and allowed several prognoses to be made.
Malashenko
A M
AM
Research Laboratory of Experimental Biological Models, Russian Academy of Medical Sciences, Otradnoe, Moscow, Russia.
Ignat'eva
E L
EL
Beskova
T B
TB
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects*; D029968:Escherichia coli Proteins; D005298:Fertility / Q000187:drug effects*; D026901:Membrane Transport Proteins / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D009004:Monosaccharide Transport Proteins; D009153:Mutagens / Q000633:toxicity*; D027981:Symporters; D013852:Thiotepa / Q000633:toxicity*
D029968:Escherichia coli Proteins; C050221:LacY protein, E coli; D026901:Membrane Transport Proteins; D009004:Monosaccharide Transport Proteins; D009153:Mutagens; D027981:Symporters; D013852:Thiotepa; C021499:lactose permease
Korreliatsiia kolebaniĭ chuvstvitel'nosti kletok kostnogo mozga k klastogennomu éffektu tioTEF i plodovitosti u mysheĭ linii CBA/LacY v riadu pokoleniĭ inbridinga.