title: Late-onset warfarin-induced skin necrosis: case report and review of the literature.
abstract: Warfarin-induced skin necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced skin necrosis and review the literature on this rarely reported variant of warfarin-induced skin necrosis. The skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C.
authors.affiliation: Department of Internal Medicine, State University of New York, Health Science Center at Brooklyn, 11203, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Essex
authors.forename: S S
authors.initials: SS
authors.lastname: Wynn
authors.forename: D K
authors.initials: DK
authors.lastname: Jin
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D019774:Blood Coagulation Factor Inhibitors / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011486:Protein C / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D013927:Thrombosis / Q000188:drug therapy; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D019774:Blood Coagulation Factor Inhibitors; D011486:Protein C; D014859:Warfarin