title: Circulating CD4+CD8+ T lymphocytes in patients with Kawasaki disease.
abstract: We serially monitored cell surface antigen expression on mononuclear cells in peripheral blood isolated from patients with Kawasaki disease (KD), and found, for the first time, that a markedly increased number of CD4+CD8+ T lymphocytes was present in some of the patients (11 of the 24 cases). The cases of five of these 11 patients were complicated with coronary artery lesion (CAL); the 13 patients with normal numbers of CD4+CD8+ T lymphocytes did not have CAL. The patients' age, sex and grade of systemic inflammation evaluated by peripheral leucocyte count and serum C-reactive protein levels were not correlated to the number of CD4+CD8+ T lymphocytes. Other cell surface antigen characteristics of the CD4+CD8+ T lymphocytes included CD3+, CD45RA+, CD45RO+, CD16-, and HLA-DR+. These results indicate that the surface antigen characteristics of the KD peripheral blood examined were the same as those of Epstein-Barr virus infection without CD45RA+. These findings provide useful information for the analysis of the pathogenesis of KD.
authors.affiliation: First Department of Paediatrics, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Hirao
authors.forename: K
authors.initials: K
authors.lastname: Sugita
mesh_terms: D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000276:immunology* / Q000628:therapy; D010641:Phenotype; D012016:Reference Values; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D005719:gamma-Globulins