title: [Effect of calcium channel blockers on developing nervous syndrome of high pressure and nitrogen narcosis in mice].
abstract: In the experiments conducted on mice which prior to compression in a heliox environment have been injected the blockers of various types of calcium channels (flunarezine, verapramil and nifedipine) as well as bemethyl (actoprotector) and oxymethacye (antioxidant) there escaped detection of noticeable effect of these drugs on developing the high pressure nervous syndrome (HPNS). On exposure to the hyperbaric nitrogen-oxygen environment verapromil (phenylalkulamine blocker of L-type calcium channels) had a protection effect with respect to a convulsive component of the nitrogen narcosis.
authors.affiliation: Institute of Evolution Physiology and Biochemistry of IM Sechenov RAN, Saint Petersburg.
authors.forename: A I
authors.initials: AI
authors.lastname: Sledkov
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004195:Disease Models, Animal; D006610:High Pressure Neurological Syndrome / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D007222:Inert Gas Narcosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice
chemical_list: D002121:Calcium Channel Blockers
vernacular_title: Vliianie blokatorov kal'tsievykh kanalov na razvitie azotnogo narkoza i nervnogo sindroma vysokikh davlenií u mysheí.