Early infection and subsequent insulin dependent diabetes.
In a study of 58 children under the age of 16 with insulin dependent diabetes (IDDM) and 172 matched non-diabetic controls, infection during the first year of life was associated with a reduction in diabetes risk (odds ratio 0.81, 95% confidence interval 0.67 to 0.98, per infective episode). Decreased exposure to common infections during infancy may be linked with subsequent IDDM.
Gibbon
C
C
MRC Environmental Epidemiology Unit, University of Southampton.
Smith
T
T
Egger
P
P
Betts
P
P
Phillips
D
D
D000293:Adolescent; D000367:Age Factors; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000209:etiology; D005194:Family Practice; D005260:Female; D006801:Humans; D006920:Hygiene; D007239:Infections / Q000453:epidemiology*; D008297:Male; D012307:Risk Factors