Early viral complications following CD34-selected autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.
A patient with non-Hodgkin's lymphoma who received a CD34-selected autologous peripheral blood stem cell transplant (PBSCT) developed cytomegalovirus retinitis, adenovirus-associated haemorrhagic cystitis (HC) and fatal herpes simplex virus pneumonia. Depletion of mature T cells from the graft and a persistent decrease in CD4+ lymphocytes following PBSCT may have predisposed this patient to such viral infections. Infusion of cryopreserved autologous PBSC (containing mature T cells) was effective for adenovirus-associated HC. Immunosuppression and resultant viral infections may affect patients receiving CD34-selected autologous transplantation.
Miyamoto
T
T
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Gondo
H
H
Miyoshi
Y
Y
Shigematsu
H
H
Minematsu
T
T
Takenaka
K
K
Tanimoto
K
K
Horiuchi
T
T
Asano
Y
Y
Inaba
S
S
Minamishima
Y
Y
Niho
Y
Y
D000257:Adenoviridae Infections / Q000150:complications; D018952:Antigens, CD34; D017726:Cytomegalovirus Retinitis / Q000150:complications; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006561:Herpes Simplex / Q000150:complications; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000628:therapy*; D016399:Lymphoma, T-Cell / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications; D011024:Pneumonia, Viral / Q000150:complications; D014777:Virus Diseases / Q000150:complications*
D018952:Antigens, CD34