title: An experimental pilot study of tacalcitol activities during modulation of parakeratotic skin features.
abstract: Establishing guidelines and experimental models preclinical and clinical evaluations of new agents for treatment, and/or prevention of human diseases has become a task of crucial importance. Psoriasis is such one disease holding great interest for dermatology owing to its high rate of incidence and complexity of treatment. However the absence of psoriatic lesions in animals and the inability to induce them, calls for experimental techniques both in vitro and in vivo. The purpose of this study was to evaluate experimentally the effects of tacalcitol on cell proliferation and differentiation process. Thereafter a human pilot study on psoriatic patients has been developed.
authors.affiliation: Dipartimento Ricerche, I.N.R.C.A., Ancona, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Tucci
authors.forename: G
authors.initials: G
authors.lastname: Ricotti
authors.forename: R
authors.initials: R
authors.lastname: Giardino
authors.forename: S
authors.initials: S
authors.lastname: Carraro
authors.forename: G
authors.initials: G
authors.lastname: Mattei
authors.forename: I
authors.initials: I
authors.lastname: Cataldi
authors.forename: G
authors.initials: G
authors.lastname: Lucarini
authors.forename: R
authors.initials: R
authors.lastname: Solmi
authors.forename: L
authors.initials: L
authors.lastname: Tosi
authors.forename: G
authors.initials: G
authors.lastname: Biagini
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D010241:Parakeratosis / Q000188:drug therapy* / Q000473:pathology; D010865:Pilot Projects; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000187:drug effects* / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D004100:Dihydroxycholecalciferols; C023850:1 alpha,24-dihydroxyvitamin D3