Therapeutic potential of anti-IgE antibodies.
Anti-IgE antibodies directed against the Fc epsilon RI-binding region on IgE inhibit binding of IgE to IgE receptors without inducing mediator release from IgE sensitized cells. In mice these antibodies selectively reduce serum IgE, inhibit antigen induced skin reactions, cytokine production by lung Th2 cells, and pulmonary eosinophil infiltration. Clinical trials in humans reveal that such antibodies are well tolerated and reduce rhinitis symptoms and early and late phase bronchoconstriction responses. Thus interruption of the allergic cascade at the IgE antibody level with non-anaphylactogenic anti-IgE antibodies is effective and represents an attractive intervention for the treatment of allergic diseases.
Heusser
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Pharmaceutical Research, Basel, Switzerland. Christoph.Heusser@Pharma.Novartis.com
Jardieu
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D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D000939:Epitopes / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D051379:Mice; D011961:Receptors, Fc / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D011961:Receptors, Fc; D007073:Immunoglobulin E