[The effect of activated macrophage products on neurite growth in an organotypic culture of chick embryo sensory ganglia].
Murine peritoneal macrophages, activated by BCG vaccine, and human peripheral blood monocytes, activated by lipopolysaccharides, exerted neurite stimulating or neurite inhibiting effects in various periods of activation. The supernatants of these preparations were active in organotypic culture of chick embryo dorsal root ganglia. The inhibition of neurite growth on the 1st day of cultivation was followed by the neurite-stimulating effect. The fluctuation of neurite-inhibition and neurite-stimulation effect of macrophage supernatants suggest the availability of certain changes in cytokine composition in different periods of macrophage activation.
Chalisova
N I
NI
Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Okulov
V B
VB
Akoev
G N
GN
Danilov
A O
AO
Zubova
S G
SG
Liudyno
M I
MI
Penniiaĭnen
V A
VA
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000648:ultrastructure; D001500:BCG Vaccine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D046508:Culture Techniques; D017950:Ganglia, Sensory / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects; D016215:Macrophage-Activating Factors / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D001500:BCG Vaccine; D008070:Lipopolysaccharides; D016215:Macrophage-Activating Factors
Vliianie produktov aktivirovannykh makrofagov na rost neĭritov v organotipicheskoĭ kul'ture chuvstvitel'nykh gangliev kurinykh émbrionov.