[New medicinal action of native hormone].
Estrogen is involved in the growth and development of female organs such as uterus and mammary gland. On the other hand, from clinical point of view, it is recently suggested that estrogen is effective to protect postmenopausal women from osteoporosis, coronary heart disease and Alzheimer disease. In order to study the molecular mechanism of estrogen action, we have identified an estrogen responsive gene, efp (estrogen-responsive finger protein), which might mediate estrogen action in various target organs at diverse stages and targeted mutagenesis of efp gene could help clarify physiologic actions of estrogen.
Orimo
A
A
Department of Biochemistry, Saitama Medical School, Japan.
Inoue
S
S
Minowa
O
O
Ikeda
K
K
Hiroi
H
H
Ogawa
S
S
Watanabe
T
T
Kuno
J
J
Noda
T
T
Muramatsu
M
M
D000544:Alzheimer Disease / Q000517:prevention & control; D000818:Animals; D003327:Coronary Disease / Q000517:prevention & control; D004268:DNA-Binding Proteins / Q000235:genetics; D004967:Estrogens / Q000494:pharmacology / Q000502:physiology; D005260:Female; D051379:Mice; D016296:Mutagenesis; D009928:Organ Specificity; D010024:Osteoporosis / Q000517:prevention & control; D011960:Receptors, Estrogen / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; D004967:Estrogens; D011960:Receptors, Estrogen; D014157:Transcription Factors; C490034:Trim25 protein, mouse