title: [Synthesis of modified oligodeoxyribonucleotides containing 9-(2'-amino-2'-deoxy-beta-D-arabinofuranosyl)adenine].
abstract: A method for preparing a modified derivative of 2'-amino-2'-deoxy-arabino-adenosine ready for directed insertion into an oligonucleotide chain during solid-phase synthesis was elaborated. A series of the title oligonucleotides (6-25-mers) containing a 2'-amino-2'-deoxy-arabino-adenosine fragment were prepared. A high reactivity of the 2'-amino group during the acylation with carboxylic acid anhydrides was demonstrated. It was shown that the insertion of the modified fragments into oligonucleotides did not inhibit the formation of the DNA duplex.
authors.forename: E M
authors.initials: EM
authors.lastname: Zubin
authors.forename: S I
authors.initials: SI
authors.lastname: Antsypovich
authors.forename: T S
authors.initials: TS
authors.lastname: Oretskaya
authors.forename: E A
authors.initials: EA
authors.lastname: Romanova
authors.forename: E M
authors.initials: EM
authors.lastname: Volkov
authors.forename: V N
authors.initials: VN
authors.lastname: Tashlitskiĭ
authors.forename: Z A
authors.initials: ZA
authors.lastname: Shabarova
mesh_terms: D000215:Acylation; D000588:Amines / Q000737:chemistry; D000812:Anhydrides / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D014740:Vidarabine / Q000737:chemistry*
chemical_list: D000588:Amines; D000812:Anhydrides; D009838:Oligodeoxyribonucleotides; D004247:DNA; D014740:Vidarabine
vernacular_title: Sintez modifitsirovannykh oligodezoksiribonukleotidov, soderzhashchikh 9-(2'-amino-2'-dezoksi-beta-D-arabinofuranozil)adenin.