Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease.
The function of the cytokine interleukin-6 (IL-6) is augmented by soluble IL-6 receptors (sIL-6R). We investigated cerebrospinal fluid sIL-6R concentrations in patients with Alzheimer's disease (AD) compared to age-matched healthy subjects and individuals with at least one first degree relative with AD. We found a statistically significant decrease in sIL-6R levels in the AD group compared to controls. Complete analysis of the IL-6R complex seems crucial to better understand the impact of IL-6 in AD pathophysiology.
Hampel
H
H
Department of Psychiatry, Ludwig-Maximilian University Munich, School of Medicine, Germany. hampel@psy.med.uni.muenchen.de
Sunderland
T
T
Kötter
H U
HU
Schneider
C
C
Teipel
S J
SJ
Padberg
F
F
Dukoff
R
R
Levy
J
J
Möller
H J
HJ
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019947:Receptors, Interleukin-6 / Q000378:metabolism*; D012044:Regression Analysis; D012995:Solubility
D019947:Receptors, Interleukin-6