Clinicopathologic aspects of 8 Kaposi's sarcomas among 1009 renal transplant patients.
In 8 of 1009 patients receiving renal grafts and consecutive immunosuppressive therapy during the last 20 years in Budapest, Hungary, Kaposi's sarcoma developed 6.5 months (average) after transplantation. Of 8 cutaneous cases of this disease, 5 also presented visceral manifestations. Seven patients died. Those with visceral tumors died because of the tumor itself. One patient affected by cutaneous tumor has survived for 5 years post-treatment. The relatively high incidence of Kaposi's sarcoma may be explained by a high infection rate with Herpes virus 8, which was shown to be positive in all three cases investigated.
Szende
B
B
1st Institute of Pathology and Experimental Cancer Research, Semmelweis University Medical School, Budapest, Hungary. bszende@korb1.sote.hu
Tóth
A
A
Perner
F
F
Nagy
K
K
Takács
K
K
D000328:Adult; D001345:Autoradiography; D015139:Blotting, Southern; D005260:Female; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D016030:Kidney Transplantation / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology / Q000821:virology; D008175:Lung Neoplasms / Q000209:etiology / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000473:pathology* / Q000821:virology; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology / Q000821:virology; D013274:Stomach Neoplasms / Q000209:etiology / Q000473:pathology / Q000821:virology