Craniofacial resection for tumors of the nasal cavity and paranasal sinuses--a 17-year experience.
BACKGROUND
The rarity of sinonasal tumors has precluded long-term follow-up of large series of craniofacial resections until now.


METHODS
A series of 209 patients suffering from a wide range of histologies who had undergone craniofacial resection for sinonasal neoplasia with up to 17 years' follow-up were analyzed.


RESULTS
An overall actuarial survival of 51% at 5 years and 41% at 10 years was found for the cohort as a whole. For malignant tumors, the 5-year actuarial survival was 44%, falling to 32% at 10 years. For benign pathology, the actuarial survival was 75% at both 5 and 10 years. Statistical analysis identified three factors which significantly affect outcome and survival: malignant histology, brain involvement, and orbital involvement. Few complications are associated with the surgery, with the mean post-operative stay being 16 days.


CONCLUSIONS
The improved survival and minimal morbidity and mortality associated with craniofacial resection make it the optimum approach to sinonasal tumors.
Lund
V J
VJ
Institute of Laryngology and Otology, London, United Kingdom.
Howard
D J
DJ
Wei
W I
WI
Cheesman
A D
AD
D000206:Actuarial Analysis; D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D002648:Child; D015331:Cohort Studies; D018572:Disease-Free Survival; D018304:Esthesioneuroblastoma, Olfactory / Q000473:pathology; D005147:Facial Bones / Q000601:surgery*; D005206:Fascia Lata / Q000637:transplantation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007902:Length of Stay; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009669:Nose Neoplasms / Q000473:pathology / Q000601:surgery*; D009918:Orbital Neoplasms / Q000473:pathology; D010027:Osteotomy / Q000009:adverse effects / Q000379:methods; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000601:surgery*; D018714:Radiotherapy, Adjuvant; D016038:Skin Transplantation / Q000009:adverse effects / Q000379:methods; D012886:Skull / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome