[Anti-arrhythmic properties of specific bradycardic agents from the group of 2-mercaptobenzimidazole derivatives].
It was shown in experiments on aconitine, calcium chloride, and epinephrine models of heart rhythm disorders that derivatives of 2-mercaptobenzimidasole possessing the properties of specific bradycardiac agents coded as SM-251, SM-266, and SM-345 cause a marked antiarrhythmic effect. SM-266 and SM-345 reduce considerably the number of ventricular fibrillations and the life-hazardous arrhythmia occurring during 7-min occlusion and subsequent reperfusion of the coronary artery in anesthetized rats. The agents under study reduced the ectopic heart rate in Harris' conscious dogs. It is concluded that the studied 2-mercaptobenzimidasole derivatives exert a marked antiarrhythmic and antifibrillatory effect.
Chichkanov
G G
GG
Laboratory of Pharmacology and Blood Circulation, Institute of Pharmacology, Russia.
Tsorin
I B
IB
Kirsanova
G Iu
GIu
Berdiaev
S Iu
SIu
Turilova
A I
AI
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D015425:Myocardial Reperfusion / Q000009:adverse effects; D011817:Rabbits; D051381:Rats; D013438:Sulfhydryl Compounds / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D013617:Tachycardia, Supraventricular / Q000139:chemically induced / Q000517:prevention & control; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control
C111158:2-(2-(diethylamino)ethyl)thio-5,6-dimethylbenzimidazole; C111159:2-(2-(diethylamino)ethyl)thio-5-ethoxybenzimidazole; C111157:2-(2-(dimethylamino)ethyl)thio-5,6-dimethylbenzimidazole; D000889:Anti-Arrhythmia Agents; D001562:Benzimidazoles; D013438:Sulfhydryl Compounds
Antiaritmicheskie svoĭstva spetsificheskikh bradikardicheskikh sredstv iz gruppy proizvodnykh 2-merkaptobenzimidazola.