Effect of early body weight and moderate dietary restriction on the survival of the Sprague-Dawley rat.
The effects of ad libitum (AL) feeding, moderate dietary restriction (DR), and initial (6-week) and one-year body weights on the two-year survival of the Sprague-Dawley (SD) rat were evaluated. DR-fed rats were given approximately 75 percent of the adult AL food intake. At two years, body weights of DR-fed males and females were approximately 69 and 58 percent of the AL-fed male and female body weights, respectively. The 2-year survival rate was 80 and 74 percent in DR-fed males and females, respectively, and 28 and 38 percent in AL-fed males and females, respectively. This increase in longevity indicates that DR-fed males and females in carcinogenicity studies would have 14.8 and 9.1 additional weeks of exposure in a 2-year period to test compounds, respectively, compared to AL-fed animals. There was no correlation between initial body weight and 2-year survival in DR or AL-fed rats. There was no association between 1-year body weight and 2-year survival among DR-fed rats. However, AL-fed rats with the greatest 1-year body weight had a lower 2-year average survival compared with the lightest AL-fed rats; this trend was statistically significant only in males. Body weights between the first and second years were statistically significantly correlated for both genders and feeding regimens but no correlation was observed between pretest and 2-year body weights. These findings demonstrate that initial body weight is not the determining factor of 2-year survival, but that the total adult food (caloric) intake is important. In conclusion, moderate dietary restriction prevented excessive body weight gain and greatly increased the 2-year survival of the SD rat. Initial body weights did not correlate to 2-year body weight gain and were not a predictive biomarker of 2-year SD rat survival.
Laroque
P
P
Laboratoires MSD-Chibret, Centre de Recherche, Clermont-Ferrand, France.
Keenan
K P
KP
Soper
K A
KA
Dorian
C
C
Gerin
G
G
Hoe
C M
CM
Duprat
P
P
D000818:Animals; D001835:Body Weight; D002423:Cause of Death; D004435:Eating / Q000502:physiology*; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley / Q000502:physiology*; D015996:Survival Rate; D015430:Weight Gain / Q000502:physiology