title: Dietary maltitol decreases the incidence of 1,2-dimethylhydrazine-induced cecum and proximal colon tumors in rats.
abstract: Maltitol is fermented in the colon due to only partial hydrolysis in the small intestine. In the present study, we examined effects of dietary maltitol on dimethylhydrazine-induced intestinal tumor in rats. In experiment 1, rats were fed a fiber-free diet or diets supplemented with 1 or 5 g/100 g maltitol for 27 wk. Each group of rats was injected with dimethylhydrazine or vehicle alone for the first 14 wk of the experimental period. Maltitol supplementation at 1 g/100 g of the diet significantly reduced tumor incidence in the cecum and the 5% supplement reduced tumor incidence in both the cecum and proximal colon in dimethylhydrazine-treated rats. In experiment 2, we investigated the effect of the 1 g/100 g maltitol diet on the short chain fatty acid concentrations in cecal contents of placebo and dimethylhydrazine-treated rats. Intake of the 1 g/100 g maltitol diet doubled (P < 0.05) the concentration of butyrate but did not affect acetate or propionate in the cecal contents. These results suggest that dietary maltitol has a protective effect against dimethylhydrazine-induced tumors in rat cecum and proximal colon and that butyrate produced by bacterial fermentation of maltitol in the cecum may be involved in the protection.
authors.affiliation: Department of Internal Medicine II, School of Medicine, Nagoya University, Showa-ku, Nagoya, 466, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tsukamura
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Arisawa
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: N
authors.initials: N
authors.lastname: Nakai
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: N
authors.initials: N
authors.lastname: Fujitsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Shimomura
mesh_terms: D019813:1,2-Dimethylhydrazine; D000818:Animals; D001835:Body Weight / Q000502:physiology; D002273:Carcinogens; D002430:Cecal Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*; D002432:Cecum / Q000502:physiology; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*; D004032:Diet; D004435:Eating / Q000502:physiology; D005232:Fatty Acids, Volatile / Q000032:analysis; D005766:Gastrointestinal Contents / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D008297:Male; D008320:Maltose / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D013402:Sugar Alcohols / Q000494:pharmacology*
chemical_list: D002273:Carcinogens; D005232:Fatty Acids, Volatile; D013402:Sugar Alcohols; D008320:Maltose; C010745:maltitol; D019813:1,2-Dimethylhydrazine