Long-term effects of CCK-agonist and -antagonist on food intake and body weight in Zucker lean and obese rats.
The present study evaluates long-term effects of the CCK-agonist caerulein and the CCK-A antagonist loxiglumide in obese and lean Zucker rats. Caerulein and loxiglumide altered food intake neither in obese nor in lean rats. By as yet unknown mechanisms, however, weight increase was accelerated by loxiglumide and reduced by caerulein in obese and lean rats. Caerulein increased pancreatic weight only in lean but not in obese rats. Thus, obese rats show a resistance of pancreatic CCK-A receptors. The failure of CCK-agonist and -antagonist to alter food intake suggests that this CCK-resistance is not responsible for obesity in the genetically altered rats.
Meereis-Schwanke
K
K
Department of Medicine, Heinrich-Heine-University, Düsseldorf, Germany.
Klonowski-Stumpe
H
H
Herberg
L
L
Niederau
C
C
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002108:Ceruletide / Q000494:pharmacology; D002766:Cholecystokinin / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000097:blood / Q000494:pharmacology; D004351:Drug Resistance; D004435:Eating / Q000187:drug effects*; D005260:Female; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000254:growth & development / Q000473:pathology; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011924:Rats, Zucker; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000378:metabolism; D012528:Satiety Response / Q000187:drug effects / Q000502:physiology
D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; C053737:loxiglumide; D002108:Ceruletide; D002766:Cholecystokinin; D011377:Proglumide