Insolubilization test of sodium chondroitin sulphate with a view to its use as colonic carrier of drugs.
Several studies have been devoted to cross-linked sodium chondroitin sulphate (SCS), in the context of numerous strategies attempting to target the colon for the absorption or the therapeutic action of a drug. SCS, a glycosaminoglycan presenting a specific degradation in the colon, is in fact soluble in water and its use as drug carrier at such a distance from the digestive tube necessitates its hydrophobisation. One method described in the literature consists in manufacturing a three-dimensional network by cross-linking with bifunctional compounds. However, all the structural characterisations carried out on the products resulting from the catalysed treatments of SCS with diaminoalkanes demonstrate that there are no cross-linking bridges between the polymer chains. Moreover, treated SCS-based tablets containing theophylline as model drug lead in vitro to dissolution profiles which are identical to those obtained with the non-treated SCS. We were therefore unable to find the announced results using the method described.
Bourie
C
C
Pierre Fabre Research Institute, Boulogne, France.
Paillard
B
B
Goutay
E
E
Avan
J L
JL
Combal
J P
JP
Bougaret
J
J
Aiache
J M
JM
Jacquinet
J C
JC
D002809:Chondroitin Sulfates / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D003106:Colon / Q000378:metabolism* / Q000382:microbiology; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D003432:Cross-Linking Reagents; D004337:Drug Carriers; D002809:Chondroitin Sulfates