title: A method for functional magnetic resonance imaging of olfaction.
abstract: A method for generating olfactory stimuli for humans within a functional magnetic resonance imaging (fMRI) experimental design is described. The system incorporates a nasal-mask in which the change from odorant to no-odorant conditions occurs in less than 500 ms and is not accompanied by visual, auditory, tactile, or thermal cues. The mask provides an ordorant-free environment following prolonged ordorant presence. Specific imaging parameters that are conducive to the study of the human olfactory system are described. In a pilot study performed using these methods, the specific patterns of activation observed converged with published experimental and clinical findings.
authors.affiliation: Department of Neuroscience, Stanford University, CA 94305, USA. nsobel@leland/stanford.edu
authors.forename: N
authors.initials: N
authors.lastname: Sobel
authors.forename: V
authors.initials: V
authors.lastname: Prabhakaran
authors.forename: J E
authors.initials: JE
authors.lastname: Desmond
authors.forename: G H
authors.initials: GH
authors.lastname: Glover
authors.forename: E V
authors.initials: EV
authors.lastname: Sullivan
authors.forename: J D
authors.initials: JD
authors.lastname: Gabrieli
mesh_terms: D001547:Benzaldehydes; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods*; D003463:Cues; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008397:Masks; D009666:Nose / Q000502:physiology*; D009812:Odorants; D010465:Perception / Q000502:physiology*; D010812:Physical Stimulation; D011422:Propionates; D012903:Smell / Q000502:physiology*; D014110:Touch
chemical_list: D001547:Benzaldehydes; D011422:Propionates; C100058:vanillin; C029658:propionic acid