title: Cataract progression in India.
abstract: OBJECTIVE
  The study was undertaken to test the feasibility of using the LOCS III cataract grading scale in the field and to determine the rate of cataract progression over a 1 year period of time.
  
  
  METHODS
  For 150 subjects between the ages of 33 and 55 who attended the refraction clinic at Aravind Eye Hospital in Madurai, India, lens abnormalities were graded at the slit lamp using the LOCS III scale. One year later, 99 of the subjects were re-evaluated by the same methodology to assess the amount of lens change.
  
  
  RESULTS
  Interrater reliability was high. A change of 0.5 or more in lens colour, cortical, nuclear, or posterior subcapsular cataract was observed in at least one eye of 54% of the subjects.
  
  
  CONCLUSIONS
  The LOCS III grading scale is a feasible method for measuring lens changes in the field with the slit lamp. Cataract progression in India is rapid enough to permit intervention studies to be performed with relatively small numbers of subjects over a short period of time (that is, 600 subjects for 2 years).
authors.affiliation: Aravind Eye Hospital, Madurai, India.
authors.forename: M
authors.initials: M
authors.lastname: Srinivasan
authors.forename: R
authors.initials: R
authors.lastname: Rahmathullah
authors.forename: C R
authors.initials: CR
authors.lastname: Blair
authors.forename: A C
authors.initials: AC
authors.lastname: Murphy
authors.forename: R W
authors.initials: RW
authors.lastname: Beck
authors.forename: J H
authors.initials: JH
authors.lastname: Wilkins
authors.forename: J P
authors.initials: JP
authors.lastname: Whitcher
authors.forename: G
authors.initials: G
authors.lastname: Smolin
mesh_terms: D000328:Adult; D002386:Cataract / Q000453:epidemiology / Q000473:pathology*; D018450:Disease Progression; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009885:Ophthalmology / Q000379:methods; D015203:Reproducibility of Results