The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?
The existence of diversity in the voltage activated Ca2+ channel populations of vertebrate cells has been long recognized. More recently, the molecular cloning of a considerable number of Ca2+ channel subunits from cDNA libraries has indicated that the range of possible Ca2+ channel phenotypes a cell can express may be even greater than was previously appreciated. A challenge of recent years has been to resolve how the properties of recombinant channels correspond with their counterparts experimentally characterized in native cells. In this short review I will outline the properties of both native and recombinant Ca2+ channels, and will then describe the current agreements and controversies concerning their relationships to each other.
Randall
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AD
Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK.
D000818:Animals; D015220:Calcium Channels / Q000235:genetics*; D003001:Cloning, Molecular; D004563:Electrochemistry; D014644:Genetic Variation; D015640:Ion Channel Gating; D010641:Phenotype
D015220:Calcium Channels