[Effect of positive end-expiratory pressure on respiration and hemodynamics in dogs with pulmonary edema caused by increased membrane permeability].
The effect of PEEP on the extravascular lung water, respiratory mechanics and hemodynamics were studied in dogs with oleic acid-induced pulmonary edema. The dogs were randomized into one of three groups according to PEEP of 0, 5 and 10 cmH2O, 60 minutes after oleic acid (0.1 ml.kg-1) injection. PEEP improved oxygenation accompanied by increased FRC and DLco. However, oxygen delivery decreased in association with the decreased cardiac index caused by application of PEEP. PEEP failed to decrease the extravascular lung water volume measured by double-indicator dilution technique after lung edema formation.
Kato
M
M
Department of Anesthesiology, Fukushima Medical College.
Otsuki
M
M
Wang
L Q
LQ
Kawamae
K
K
Tase
C
C
Okuaki
A
A
D000818:Animals; D002463:Cell Membrane Permeability; D004195:Disease Models, Animal; D004285:Dogs; D015633:Extravascular Lung Water / Q000378:metabolism; D006439:Hemodynamics; D019301:Oleic Acid; D011175:Positive-Pressure Respiration; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy; D011897:Random Allocation; D012119:Respiration
D019301:Oleic Acid