[The action of insulin on cardiac contractility in active, hibernating and arousing susliks Citellus undulatus].
During the deep hibernation (at 5-6 degrees C of the heart temperature) and during arousal from hibernation (at 15-16 degrees C) insulin have no effect on contractility. Two opposite inotropic effects of insulin at concentrations 0.1-50 nM were found at higher temperature of arousing: a transient positive inotropic effect between 21-28 degrees C, and a negative one (about 20-30% from the control value) above 28 degrees C. In active summer and winter animals insulin produced mainly the negative inotropic effect.
Nakipova
O V
OV
Institute of Cell Biophysics, Russian Acad. Sci., Pushchino, Moscow Region.
Gaĭnullin
R Z
RZ
Safronova
V G
VG
Kosarskiĭ
L S
LS
Bakaneva
B F
BF
Ignat'ev
D A
DA
Amerkhanov
Z G
ZG
Kolaeva
S G
SG
Kukushkin
N I
NI
Solomonov
N G
NG
D000818:Animals; D001143:Arousal / Q000502:physiology*; D006605:Hibernation / Q000502:physiology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology* / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects*; D012589:Sciuridae / Q000502:physiology*
D007004:Hypoglycemic Agents; D007328:Insulin
Vliianie insulina na izmenenie napravleniia inotropii sokrashcheniia miokarda giberniruiushchego suslika Citellus undulatus na razlichnykh stadiiakh protsessa probuzhdeniia.