title: Bronchiolar-alveolar carcinoma in a cow.
abstract: Bronchiolar-alveolar carcinoma was observed in the lung of an 8-year-old Holstein cow. Grossly, the lung contained multiple tumour masses, which were solid, yellowish-white in colour, and firm in consistency. These tumours also occurred in the liver, pancreas, uterus and lymph nodes in the thoracic, abdominal and pelvic cavities. Histologically, the masses were composed of abundant fibrous stroma and proliferating atypical cuboidal epithelial cells, occasionally forming glandular structures. Electron microscopy revealed that the neoplastic cells had microvilli and lamellar bodies in the cytoplasm, suggesting that they originated from immature respiratory epithelial cells differentiating towards either Clara cells or type II pneumocytes.
authors.affiliation: Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Ochiai
authors.forename: K
authors.initials: K
authors.lastname: Osaki
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: C
authors.initials: C
authors.lastname: Itakura
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000473:pathology* / Q000556:secondary / Q000648:ultrastructure / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D005260:Female; D008175:Lung Neoplasms / Q000473:pathology* / Q000648:ultrastructure / Q000662:veterinary*