Effect of the quassinoids glaucarubolone and simalikalactone D on growth of cells permanently infected with feline and human immunodeficiency viruses and on viral infections.
Growth of Crandall feline kidney cells permanently infected with feline immunodeficiency virus was inhibited by the anti-cancer quassinoid glaucarubolone whereas growth of uninfected cells was not inhibited. Similar results were obtained for human MOLT-4 cells infected with HIV-1. The results suggest that cell lines permanently infected with either the feline or the human lentivirus exhibit growth response characteristics to the quassinoids in common with other cell lines malignantly transformed. In addition the quassinoids may delay viral infection suggesting some commonality between the mechanism responsible for inhibition of the growth of the transformed phenotype and viral infection.
Morré
D J
DJ
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA.
Zeichhardt
H
H
Maxeiner
H G
HG
Grünert
H P
HP
Sawitzky
D
D
Grieco
P
P
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002415:Cats; D002455:Cell Division / Q000187:drug effects*; D002472:Cell Transformation, Viral / Q000187:drug effects*; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects*; D036702:Quassins
D000972:Antineoplastic Agents, Phytogenic; D036702:Quassins; C024967:glaucarubolone; C024970:simalikalactone D; D005900:Glaucarubin