title: The change of periapical exudate prostaglandin E2 levels during root canal treatment.
abstract: We have previously demonstrated that detectable levels of prostaglandin E2 exist in periapical exudates (PE-PGE2) from root canals of periapical periodontitis. Our data from a cross-sectional study also suggested the association of PE-PGE2 concentrations with the active phase of periapical lesions. The objective of this study was to investigate the longitudinal changes of PE-PGE2 levels during root canal treatment. Periapical exudate specimens were quantitatively sampled from root canals of 20 nonvital teeth at consecutive treatment visits to measure PGE2 concentrations. The mean PE-PGE2 levels significantly decreased following the endodontic therapy (158.0 +/- 54.1 pg/microliter in the first samples versus 48.4 +/- 37.9 pg/microliter in the second samples). A significant correlation was also found between the changes in PE-PGE2 levels and the clinical disease expression of periapical periodontitis (p < 0.01). Decreased PGE2 production is considered to reflect the remission of disease activity. These results suggest the central roles of PGE2 in regulatory mechanisms for the expression of periapical disease.
authors.affiliation: Department of Periodontology and Endodontology, Osaka University Faculty of Dentistry, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shimauchi
authors.forename: S
authors.initials: S
authors.lastname: Takayama
authors.forename: Y
authors.initials: Y
authors.lastname: Miki
authors.forename: H
authors.initials: H
authors.lastname: Okada
mesh_terms: D003786:Dental Pulp Cavity; D015232:Dinoprostone / Q000032:analysis*; D005122:Exudates and Transudates / Q000737:chemistry*; D006801:Humans; D010485:Periapical Periodontitis / Q000378:metabolism / Q000628:therapy; D010486:Periapical Tissue / Q000737:chemistry*; D012390:Root Canal Therapy
chemical_list: D015232:Dinoprostone