[Congenital toxoplasmosis and seroconversion at the end of pregnancy: clinical observations].
We report seven cases of subclinical congenital toxoplasmosis secondary to maternal primary infections. Mothers were infected between two and four weeks prior to delivery. The diagnostic criteria of congenital infections included: IgM antibody (Ab) (1 case); IgM and IgA Ab (1 case); a real IgG seroconversion in the neonatal and postnatal samples (3 cases); persistence of IgG Ab beyond 6 months post-delivery (2 cases). A treatment was initiated, including a combination of pyrimethamine + sulfadiazine (6 cases); trimethoprim + sulfamethoxazole (1 case). This retrospective study suggests that it is important to screen the non-immune pregnant women until delivery. We confirmed the usefulness of a combination of isotypes of antibodies for the accurate assessment of congenital infection. Finally, infected infants have to be treated and monitored clinically and immunologically during the first year of life.
Luyasu
V
V
Service de Biologie Clinique, Clinique Saint-Pierre, Ottignies.
Bauraind
O
O
Bernard
P
P
Bietlot
Y
Y
Brasseur
C
C
Englebert
J
J
Fiasse
L
L
Givron
O
O
Longueville
E
E
Melard
J L
JL
Michel
M
M
Wacquez
M
M
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000913:Antibodies, Protozoan / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000302:isolation & purification; D007231:Infant, Newborn; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy / Q000276:immunology*; D012189:Retrospective Studies; D015572:Spiramycin / Q000627:therapeutic use; D014123:Toxoplasmosis / Q000188:drug therapy / Q000276:immunology*; D014125:Toxoplasmosis, Congenital / Q000188:drug therapy / Q000276:immunology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000913:Antibodies, Protozoan; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D015572:Spiramycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
Toxoplasmoses congénitales et séroconversions de fin de grossesse: observations cliniques.