title: Further antineoplastic terpenylquinones and terpenylhydroquinones.
abstract: Influences of the quinone/hydroquinone fragment and other structural features are considered in relation with the antineoplastic activity and selectivity of terpenylquinones/hydroquinones. Several compounds have shown IC50 values under the microM level.
authors.affiliation: Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Miguel del Corral
authors.forename: M
authors.initials: M
authors.lastname: Gordaliza
authors.forename: M A
authors.initials: MA
authors.lastname: Castro
authors.forename: M M
authors.initials: MM
authors.lastname: Mahiques
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
authors.forename: M D
authors.initials: MD
authors.lastname: García-Grávalos
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011809:Quinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D006873:Hydroquinones; D011809:Quinones; D013729:Terpenes