Neuropeptide Y antibody attenuates 2-deoxy-D-glucose induced feeding in rats.
2-deoxy-D-glucose (2-DG) has been shown to induce increased feeding responses in animals. Recent studies suggest the possible involvement of neuropeptide Y (NPY) in 2-DG-induced feeding. The present study examined the effect of immunoneutralization of endogenous NPY on 2-DG-induced feeding. NPY antibody injected into the paraventricular nucleus of the rats significantly attenuated 2-DG-induced feeding, suggesting that hypothalamic NPY may mediate, at least partly, the effect of 2-DG on food intake.
He
B
B
Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA.
White
B D
BD
Edwards
G L
GL
Martin
R J
RJ
D000818:Animals; D003847:Deoxyglucose / Q000276:immunology / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D007106:Immune Sera; D008297:Male; D009478:Neuropeptide Y / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007106:Immune Sera; D009478:Neuropeptide Y; D003847:Deoxyglucose