title: [Relationship between alcoholism and CYP2E1 genotypes].
abstract: The genotype of the CYP2E1 loci in 36 alcoholic and 42 non-alcoholic (healthy) Japanese were investigated to examine the relationship between the polymorphisms of CYP2E1 (C/D) and the susceptibility to alcohol dependence. There was a significant (df = 1, chi 2 = 4.39, p < 0.05) difference in CYP2E1 CD (heterozygote) genotype frequency between alcohol dependents (56%) and controls (33%), suggesting that the CD (heterozygote) genotype of CYP2E1 may have something to the risk of developing alcoholism in Japanese, whereas DD (homozygote) genotype was high among controls.
authors.affiliation: Department of Neuropsychiatry, Kagawa Medical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakae
authors.forename: K
authors.initials: K
authors.lastname: Iwahashi
authors.forename: S
authors.initials: S
authors.lastname: Ameno
authors.forename: K
authors.initials: K
authors.lastname: Ameno
authors.forename: N
authors.initials: N
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Suwaki
authors.forename: I
authors.initials: I
authors.lastname: Ijiri
authors.forename: S
authors.initials: S
authors.lastname: Harada
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000201:enzymology* / Q000235:genetics*; D044466:Asian People; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012306:Risk
chemical_list: D019392:Cytochrome P-450 CYP2E1