Injection of low and iso-osmolar contrast medium decreases oxygen tension in the renal medulla.
The oxygen tension (PO2) in the renal cortex and outer renal medulla in 26 rats was studied by use of oxygen microelectrodes before and after injection of x-ray contrast media (CM). The CM, iopromide, ioxaglate and iotrolan were administrated intravenously in iodine equivalent doses (1,600 mg iodine/kg body wt). Ringer's solution was used as the control. In the outer medulla, all three CM induced a decrease in PO2: iopromide (N = 6) from 30 +/- 3 to 18 +/- 4 mm Hg; ioxaglate (N = 7) from 32 +/- 6 to 15 +/- 4 mm Hg; and iotrolan (N = 6) from 36 +/- 3 to 14 +/- 4 mm Hg. All these decreases were significant. After the injection of Ringer's (N = 7) there was an increase from 34 +/- 3 to 35 +/- 3 mm Hg. In the cortex a slight decrease was noted for injection of CM, but this was significant only after injection of iotrolan. All tested contrast media decrease PO2 in the outer renal medulla, which may partly explain contrast medium-induced acute renal failure.
Liss
P
P
Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
Nygren
A
A
Erikson
U
U
Ulfendahl
H R
HR
D058186:Acute Kidney Injury / Q000139:chemically induced; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage* / Q000633:toxicity*; D000860:Hypoxia / Q000139:chemically induced; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity; D007485:Ioxaglic Acid / Q000008:administration & dosage / Q000633:toxicity; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism; D007679:Kidney Medulla / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D012079:Renal Circulation / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000633:toxicity
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C033300:iotrolan; D007472:Iohexol; C038192:iopromide; D010100:Oxygen; D007485:Ioxaglic Acid