Grouping of anticancer drugs based on administration method-related toxicity patterns in rats.
As part of the study of the appropriate usage of anticancer drugs, and the effects of the administration method (single dose, or divided doses) on the death rate from toxicity, five anticancer drugs (nimustine hydrochloride = ACNU, cyclophosphamide = CY, carboplatine = CBDCA, mitomycin C = MMC, vindesine = VDS) were studied in F-344 rats. A reduced death rate from toxicity was achieved by divided-dose administration of ACNU and CBDCA (group 1), but it was higher for CY and VDS (group 2), and there was no significant difference with MMC (group 3). In conclusion, the drugs were divided into three groups according to the administration method-related toxicity patterns. Improved knowledge of the properties of anticancer drugs is important for the success of chemotherapy.
Mizushima
Y
Y
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Li
H
H
Sassa
K
K
Fujishita
T
T
Oosaki
R
R
Kobayashi
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000633:toxicity*; D016026:Bone Marrow Transplantation / Q000502:physiology*; D016190:Carboplatin / Q000008:administration & dosage / Q000633:toxicity; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity; D004334:Drug Administration Schedule; D007275:Injections, Intravenous; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage / Q000633:toxicity; D015376:Nimustine / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344; D014185:Transplantation, Isogeneic; D014751:Vindesine / Q000008:administration & dosage / Q000633:toxicity
D000970:Antineoplastic Agents; D015376:Nimustine; D016685:Mitomycin; D003520:Cyclophosphamide; D016190:Carboplatin; D014751:Vindesine