Effects of soya milk and Bifidobacterium-fermented soya milk on plasma and liver lipids, and faecal steroids in hamsters fed on a cholesterol-free or cholesterol-enriched diet.
The effects of freeze-dried soya milk (SM) and Bifidobacterium-fermented soya milk (FSM) on plasma and liver lipids, and faecal steroid excretion were estimated in hamsters fed on a cholesterol-free or cholesterol-enriched diet. Hamsters fed on the cholesterol-free diet containing 300 g FSM/kg had lower levels of plasma VLDL + LDL cholesterol than the animals fed on the control diet. SM in the diet produced a similar pattern without significant differences. In the cholesterol-enriched diet group, SM and FSM decreased the levels of plasma total cholesterol and VLDL + LDL-cholesterol. SM and FSM decreased the plasma triacylglycerol level in both the cholesterol-free and -enriched diet groups. The liver total cholesterol contents in the SM and FSM groups were lower than that in the control group, for hamsters fed on the cholesterol-free diet. The liver triacylglycerol content was not modified by SM or FSM in hamsters fed on either the cholesterol-free or -enriched diet. SM and FSM increased the total bile acid excretion and the proportion of cholesterol entering the cholic acid biosynthesis pathway in both the cholesterol-free and -enriched diet groups. SM and FSM did not affect neutral steroid excretion in the cholesterol-free or -enriched diet group. There was an inverse relationship between VLDL + LDL-cholesterol and faecal bile acid excretion in hamsters fed on the cholesterol-free (r -0.670, P < 0.01) and cholesterol-enriched (r -0.761, P < 0.001) diets respectively. These results indicated that SM had an anti-atherogenic effect, and that this effect was not diminished by prior fermentation.
Kikuchi-Hayakawa
H
H
Yakult Central Institute for Microbiological Research, Tokyo, Japan.
Onodera
N
N
Matsubara
S
S
Yasuda
E
E
Shimakawa
Y
Y
Ishikawa
F
F
D000704:Analysis of Variance; D000818:Animals; D001644:Bifidobacterium; D001647:Bile Acids and Salts / Q000032:analysis; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D008078:Cholesterol, LDL / Q000032:analysis / Q000097:blood; D015243:Cholesterol, VLDL / Q000032:analysis / Q000097:blood; D006224:Cricetinae; D005243:Feces / Q000737:chemistry; D005285:Fermentation; D005612:Freeze Drying; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D013024:Soybean Oil / Q000008:administration & dosage* / Q000378:metabolism; D013261:Sterols / Q000032:analysis; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D013261:Sterols; D014280:Triglycerides; D013024:Soybean Oil; D002784:Cholesterol