Testing of decomposition of pyridinedicarboxylic acid derivatives in selected pharmaceutical preparations.
Decomposition of nifedipine in Adalat tabl. and Cordafen drops and nitrendipine in Nitrendipine tabl. preparations under influence of UV radiation operation and temperature of 50 degrees C was tested. Chromatographic methods of TLC and HPCL and spectrophotometry were used for evaluation of the decomposition processes.
Bogdan
A
A
Drug Institute, Warsaw, Poland.
Kaniewska
T
T
D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000528:radiation effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D009543:Nifedipine / Q000737:chemistry* / Q000528:radiation effects; D009568:Nitrendipine / Q000737:chemistry* / Q000528:radiation effects; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays
D002121:Calcium Channel Blockers; D009568:Nitrendipine; D009543:Nifedipine