title: [Specific features of cellular immunity of pulmonary tuberculosis in patients with diabetes mellitus].
abstract: The parameters of cellular immunity were studied in 64 patients with pulmonary tuberculous developed in the presence of type 1 diabetes mellitus and compared with those in 36 patients with pulmonary tuberculosis alone. Patients with concomitant abnormalities showed higher depression of cellular immunity appeared as fewer T lymphocytes and their decreased capacity for blast-cell transformation than those with tuberculosis alone. Immunological parameters became normal only due to complex chemo- and immunotherapies (with T-activin). In addition, treatment outcomes improve and more rapid and frequent abacillation occurs. The development of tuberculosis in patients with diabetes mellitus is an additional indication for immunostimulant therapy with T-activin.
authors.forename: M A
authors.initials: MA
authors.lastname: Karachunskiĭ
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Gergert
authors.forename: O B
authors.initials: OB
authors.lastname: Iakovleva
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D016516:CD4-CD8 Ratio; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology / Q000628:therapy; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007167:Immunotherapy; D007328:Insulin / Q000627:therapeutic use; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D010455:Peptides / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013949:Thymus Extracts / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000276:immunology* / Q000628:therapy
chemical_list: D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D007004:Hypoglycemic Agents; D007328:Insulin; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
vernacular_title: Osobennosti kletochnogo immuniteta pri tuberkuleze legkikh u bol'nykh sakharnym diabetom.