GM1 ganglioside potentiates trimethyltin-induced expression of interleukin-1 beta and the nerve growth factor in reactive astrocytes in the rat hippocampus: an immunocytochemical study.
This study demonstrates potentiation by GM1 ganglioside treatment of trimethyltin (TMT) induced reactivity of astrocytes, and the expression of astroglial interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) immunoreactivities in the rat hippocampus. GM1 treatment also results in an increase of the number of IL-1 beta and NGF immunoreactive astrocytes. Both the intensity of gliosis and stimulation of IL-1 beta and NGF expression in astrocytes mostly occurs in the regions of heaviest neurodegeneration in the hippocampus (CA4/CA3c and CA1). It is tempting to assume that enhancement of astroglial NGF expression by GM1 ganglioside may play a role in the protective action of GM1 against neurotoxic insult.
Oderfeld-Nowak
B
B
Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Science, Warszawa.
Zaremba
M
M
D000818:Animals; D001253:Astrocytes / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D004357:Drug Synergism; D005677:G(M1) Ganglioside / Q000008:administration & dosage*; D006624:Hippocampus / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D009414:Nerve Growth Factors / Q000032:analysis / Q000096:biosynthesis* / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014298:Trimethyltin Compounds / Q000008:administration & dosage*
D007375:Interleukin-1; D009414:Nerve Growth Factors; D014298:Trimethyltin Compounds; D005677:G(M1) Ganglioside; C040533:trimethyltin chloride