title: Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression.
abstract: OBJECTIVE
  Increased frequency and severity of signal hyperintensities have been regularly reported in elderly depressed patients compared with normal subjects, however, greater neuroanatomic localization of lesions has been limited.
  
  
  METHODS
  T2-weighted MRI scans in elderly depressed patients (n = 35) and normal comparison subjects (n = 31) were assessed for signal hyperintensities in lateralized discrete brain regions.
  
  
  RESULTS
  Logistic regression revealed that left frontal deep white matter (P<.005) and left putaminal (P<.04) hyperintensities significantly predicted depressive group assignment.
  
  
  CONCLUSIONS
  Findings suggest that greater neuroanatomic localization of hyperintensities than heretofore appreciated may relate to late-life depression.
authors.affiliation: Department of Psychiatry, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA. greenwal@lij.edu
authors.forename: B S
authors.initials: BS
authors.lastname: Greenwald
authors.forename: E
authors.initials: E
authors.lastname: Kramer-Ginsberg
authors.forename: K R
authors.initials: KR
authors.lastname: Krishnan
authors.forename: M
authors.initials: M
authors.lastname: Ashtari
authors.forename: C
authors.initials: C
authors.lastname: Auerbach
authors.forename: M
authors.initials: M
authors.lastname: Patel
mesh_terms: D000368:Aged; D001931:Brain Mapping; D003863:Depression / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D006973:Hypertension / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male