title: [The importance of determination of interleukin-10 in the blood of patients with systemic lupus erythematosus].
abstract: BACKGROUND
  Hitherto, not very numerous investigations provided so far only few often controversial findings on the importance of interleukin-10 (IL-10) in systemic lupus erythematosus (SLE). The objective of the present investigation was to assess whether there exist practically applicable relations between the serum level of IL-10, clinical and laboratory indicators of activity of the disease and serum levels of selected cytokines or their soluble receptors.
  
  
  RESULTS
  The authors analyzed a group of 23 patients with SLE (23 women and 1 man, median age 37 years). Interleukin-10 and other cytokines were examined by the ELISA method, the clinical activity of the disease was evaluated by the ECLAM system (European Consensus Lupus Activity Measurement). Elevated IL-10 values (> 5 pg/ml) were assessed in 10 (43%) patients. Correlation analysis (Pearson's test, p < 0.05) revealed statistically significant relations between IL-10 levels and the activity of the disease, values of antibody levels against dsDNA and levels of the soluble receptor IL-2 (sIL-2R) in serum. Conversely, no relationship was revealed between values of IL-10 and values of C3 and C4 complement components, IL-1, IL-2, IL-6, sIL-6R, TNF-alpha, sTNFR-alpha and INF-gamma.
  
  
  CONCLUSIONS
  Elevated IL-10 serum levels in patients with SLE did not have, with the exception of the index of clinical activity of the disease, antibodies against dsDNA and sIL-2R any statistically significant relations to laboratory indicators of disease activity and levels of selected cytokines and their soluble receptors.
authors.affiliation: III. interní klinika LF UK a FN, Olomouc.
authors.forename: V
authors.initials: V
authors.lastname: Scudla
authors.forename: P
authors.initials: P
authors.lastname: Horák
authors.forename: L
authors.initials: L
authors.lastname: Faltýnek
authors.forename: Z
authors.initials: Z
authors.lastname: Pospísil
authors.forename: M
authors.initials: M
authors.lastname: Budíková
authors.forename: Z
authors.initials: Z
authors.lastname: Hermanová
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D016753:Interleukin-10
vernacular_title: Význam vysetrení interleukinu-10 v séru nemocných se systémovým lupus erythematodes.