title: Erythrocyte aging in the demented elderly: a fluctuating process?
abstract: Measurement of erythrocyte aging parameters in patients with dementia indicates that an Alzheimer-related disturbance of the erythrocyte aging process may not be detectable until in the more advanced stages of the disease. Also, a strong fluctuation in the values of erythrocyte aging parameters, over a period of 15 months, was observed in patients with dementia, but not in age-matched control donors. This fluctuation was independent of the type and stage of dementia, and its cause remains to be elucidated. Such variability hampers the use of erythrocyte aging characteristics for the diagnosis of dementia. On the other hand, the aging-related erythrocyte IgG content may be a sensitive biomarker for disturbed systemic homeostasis in the elderly.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Nijmegen, The Netherlands. G.Bosman@bioch.kun.nl
authors.forename: G J
authors.initials: GJ
authors.lastname: Bosman
authors.forename: P A
authors.initials: PA
authors.lastname: Van der Linden
authors.forename: I G
authors.initials: IG
authors.lastname: Bartholomeus
authors.forename: A J
authors.initials: AJ
authors.lastname: De Man
authors.forename: W J
authors.initials: WJ
authors.lastname: De Grip
authors.forename: P J
authors.initials: PJ
authors.lastname: Van Kalmthout
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism; D003704:Dementia / Q000097:blood* / Q000276:immunology; D004905:Erythrocyte Aging / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis
chemical_list: D001457:Anion Exchange Protein 1, Erythrocyte; D007074:Immunoglobulin G