title: Attention deficits in childhood-onset schizophrenia: reaction time studies.
abstract: The hypothesis of continuity between childhood-onset and adult schizophrenia was tested by comparing the performance of 15 patients with childhood-onset schizophrenia and 52 age-matched controls on 2 reaction time paradigms that have been used to study adult schizophrenia. On simple reaction time to tones with regular and irregular preparatory intervals of 2, 4, and 8 s, patients showed greater effects of the length of the preparatory interval in the regular condition and greater effects of the preparatory interval (girls only) and the preceding preparatory interval in the irregular series. On simple reaction time to random lights and tones, patients were faster on ipsimodal sequences than cross-modal sequences compared with controls. Overall, patients were much slower than controls in both paradigms. The results suggest similar attention dysfunction as is found in adult schizophrenia and thus are consistent with the continuity hypothesis.
authors.affiliation: Laboratory of Brain and Cognition, NIMH, Bethesda, Maryland 20892-1366, USA. ted_zahn@nih.gov
authors.forename: T P
authors.initials: TP
authors.lastname: Zahn
authors.forename: L K
authors.initials: LK
authors.lastname: Jacobsen
authors.forename: C T
authors.initials: CT
authors.lastname: Gordon
authors.forename: K
authors.initials: K
authors.lastname: McKenna
authors.forename: J A
authors.initials: JA
authors.lastname: Frazier
authors.forename: J L
authors.initials: JL
authors.lastname: Rapoport
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time; D012561:Schizophrenia, Childhood / Q000145:classification / Q000175:diagnosis* / Q000523:psychology