[Doppler sonographic monitoring control of perfusion of hepatocellular carcinoma after arterial chemoembolization].
BACKGROUND
22 patients with hepato-cellular carcinomas were examined sonographically before and after intra-arterial chemo-embolisation. The aim was to evaluate different techniques for judging tumour morphology and for assessing changes in perfusion.


METHODS
The morphological appearances and perfusion changes were analysed by means of colour coded duplex sonography and power Doppler sonography before and after intravenous contrast medium. Pulsatility (Pl) and resistance index (RI) were used as quantitative parameters for judging changes in perfusion.


RESULTS
In 13 patients intra-tumoral arteries were identified by duplex sonography and in four patients only by the power Doppler procedure. In three patients arterial vessels could only be identified after intravenous contrast. In 9 patients it was possible to document a reduction in arterial perfusion following embolisation. The indices calculated from these findings gave no prognostic indication.


CONCLUSIONS
The methods described give information concerning changes in perfusion of a tumour following chemo-embolisation and, in conjunction with CT and clinical findings, provide indications for further tumour embolisation.
Steger
W
W
Strahlenklinik und Poliklinik, Virchow Klinikum, Humboldt-Universität Berlin.
Vogl
T J
TJ
Hosten
N
N
Steger
S
S
Hidajat
N
N
Felix
R
R
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005500:Follow-Up Studies; D006499:Hepatic Artery / Q000000981:diagnostic imaging*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy*; D010477:Perfusion; D015203:Reproducibility of Results; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D018608:Ultrasonography, Doppler
D004317:Doxorubicin; D002945:Cisplatin
Dopplersonographische Verlaufskontrolle der Perfusion hepatozellulärer Karzinome nach arterieller Chemoembolisation.