title: T1 effects in sequential dynamic susceptibility contrast experiments.
abstract: Residual effects of an initial bolus of gadolinium contrast agent have been previously demonstrated in sequential dynamic susceptibility contrast MR experiments. While these residual effects quickly reach a saturation steady state, their etiology is uncertain, and they can lead to spurious estimates of hemodynamic parameters in activation experiments. The possible influence of T1 effects is now investigated with experiments in which T1 weighting is varied as well as with serial regional T1 measurements. Little evidence for significant residual T1 effects is found, suggesting instead that susceptibility effects underlie these observations. An initial saturation dose of contrast agent minimizes this effect.
authors.affiliation: Brain Imaging Center, Harvard Medical School, Belmont, Massachusetts, 02178, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Levin
authors.forename: L L
authors.initials: LL
authors.lastname: Wald
authors.forename: M J
authors.initials: MJ
authors.lastname: Kaufman
authors.forename: M H
authors.initials: MH
authors.lastname: Ross
authors.forename: L C
authors.initials: LC
authors.lastname: Maas
authors.forename: P F
authors.initials: PF
authors.lastname: Renshaw
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003287:Contrast Media / Q000008:administration & dosage; D005682:Gadolinium; D006571:Heterocyclic Compounds / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium