Telomeres and senescence: the history, the experiment, the future.
Telomere length has been proposed to signal entry into cellular senescence. Expression of the human telomerase subunit, hTERT, in primary cells now shows that these cells bypass senescence.
Greider
C W
CW
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 617 Hunterian Building, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA. cgreider@bs.jhmi.edu
D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000502:physiology*
D019098:Telomerase