Immune system activation by cisplatin and its analog 'poly-plat': an in vitro and in vivo study.
Swiss Webster mice treated with bolus injections of 'poly-plat' (10 mg/kg) show increased macrophage activation after 2 and 12 days when isolated in cultures. Such macrophages demonstrate an increase in the number of lysosomes and cytoplasmic extension formation with enhanced cytokine (interleukin-1alpha) activity. In addition, peripheral blood smears demonstrated an increase in lymphocytes and monocytes compared to cisplatin-treated animals. These results show that 'poly-plat' activates the immune system more effectively than cisplatin both in vitro and in vivo.
Muenchen
H J
HJ
Department of Zoology, Michigan State University, East Lansing 48824-1115, USA.
Aggarwal
S K
SK
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002448:Cell Adhesion; D007375:Interleukin-1 / Q000378:metabolism; D007958:Leukocyte Count / Q000187:drug effects; D008262:Macrophage Activation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D007375:Interleukin-1; D009944:Organoplatinum Compounds; C111406:poly(trans-1,2-diaminocyclohexane)platinum-carboxyamylose; D009569:Nitric Oxide