Sustained local drug delivery from a radiopaque implanted reservoir.
A new polymeric biomaterial that contains covalently bound iodine, and is therefore radiopaque, was used to construct a sustained local drug-delivery device. A polymeric wall was designed to be porous (i.e., passage of low-molecular-weight molecules across the wall is possible), self-healing, and biocompatible. Once implanted, the sphere cavity can be filled and refilled with a concentrated solution of a (cytostatic) drug, which is subsequently released by slow diffusion into the tissue region surrounding the sphere. This principle of sustained local drug delivery is shown by a series of in vitro experiments on the release of 5-fluorouracil, and in vivo animal experiments, using x-ray fluoroscopic and scintigraphic techniques.
Koole
L H
LH
Centre for Biomaterials Research, University of Maastricht, The Netherlands. l.koole@bioch.unimaas.nl
Kruft
M A
MA
Aldenhoff
Y B
YB
van 't Oost
N E
NE
van Kroonenburgh
M J
MJ
van der Veen
F H
FH
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001672:Biocompatible Materials; D003287:Contrast Media; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005471:Fluoroscopy; D005472:Fluorouracil / Q000008:administration & dosage; D007455:Iodine; D007463:Iodobenzoates; D008297:Male; D008689:Methacrylates; D011108:Polymers; D011817:Rabbits; D051381:Rats; D011921:Rats, Inbred WKY
C092619:2-(4-iodobenzoyl)ethyl methacrylate; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003287:Contrast Media; D003692:Delayed-Action Preparations; D007463:Iodobenzoates; D008689:Methacrylates; D011108:Polymers; C005044:hydroxyethyl methacrylate; D007455:Iodine; D005472:Fluorouracil