title: Giant lamellar bodies in a pulmonary MALT lymphoma: a case report with ultrastructural and immunohistochemical studies.
abstract: A 35-year-old, African-American man presented with a 7-year history of a persistent, enlarging pulmonary infiltrate in the right middle lobe associated with three episodes of right-sided pneumonia, recent 12-lb weight loss, and progressive shortness of breath. The nature of the right middle lobe infiltrate was unclear, but recurrent aspiration pneumonia and carcinoma of lung were important considerations. Exploratory thoracotomy with partial lobectomies revealed a low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). Clusters of giant lamellar bodies were a unique finding in this lymphoma. Results of ultrastructural and immunohistochemical studies gave support to the views that these inclusions were derived from both products of cellular degeneration and surfactant. The pulmonary lymphoma subsequently spread to the gastric mucosa. The patient is alive with lymphoma 5 years after the initial diagnosis was made.
authors.affiliation: Pathology and Laboratory Medicine Service, Department of Veterans Affairs Medical Center, Washington, DC 20422, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Guccion
authors.forename: P K
authors.initials: PK
authors.lastname: Rohatgi
authors.forename: R H
authors.initials: RH
authors.lastname: Patterson
authors.forename: J
authors.initials: J
authors.lastname: Hall
mesh_terms: D000328:Adult; D006801:Humans; D007128:Immunoglobulin Fragments / Q000032:analysis; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000473:pathology* / Q000648:ultrastructure*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology* / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D011663:Pulmonary Surfactants / Q000032:analysis
chemical_list: D007128:Immunoglobulin Fragments; D011663:Pulmonary Surfactants