Oral phentolamine as treatment for erectile dysfunction.
OBJECTIVE
For most patients with erectile dysfunction oral agents are a preferred treatment option. Oral or buccal phentolamine has been shown to produce full erections in impotent subsets of study populations. We evaluate the efficacy of oral phentolamine.


METHODS
After a comprehensive evaluation 44 patients with recent onset (less than 3 years) of erectile dysfunction and a high likelihood of organogenic etiology underwent a prospective, double-blind and placebo controlled trial with oral phentolamine after placebo.


RESULTS
After placebo 4 of the 44 patients who reported full erections were excluded from study. Of the 40 patients in the double-blind phase full erections were achieved by 2 of 10 with placebo, and 3 of 10 with 20 mg., 5 of 10 with 40 mg. and 4 of 10 with 60 mg. phentolamine. There were no serious complications observed during the study, and only a single minor side effect occurred in 1 patient after 60 mg. phentolamine.


CONCLUSIONS
Our results indicate that oral phentolamine may be of benefit for the treatment of erectile dysfunction. Further studies are required to corroborate our findings.
Becker
A J
AJ
Department of Urology, Medizinsche Hochschule Hannover, Germany.
Stief
C G
CG
Machtens
S
S
Schultheiss
D
D
Hartmann
U
U
Truss
M C
MC
Jonas
U
U
D000284:Administration, Oral; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D010646:Phentolamine / Q000008:administration & dosage*; D011446:Prospective Studies
D000317:Adrenergic alpha-Antagonists; D010646:Phentolamine