title: The human blood pressure chronome: a biological gauge of aging.
abstract: OBJECTIVE
  This study examines changes in the broad time structure (chronome) of blood pressure (BP) as a function of age.
  
  
  METHODS
  This is an observational study.
  
  
  METHODS
  The study was conducted at the Chronobiology Laboratories of the University oi Minnesota, Minneapolis, Minnesota.
  
  
  METHODS
  Seventy-two individuals 12 to 106 years of age provided a 7-day record of BP measured indirectly with an ambulatory monitor, mostly at 15-60-minute intervals.
  
  
  METHODS
  Amplitudes in least squares spectra at frequencies of 1 to 7 cycles per week and 1 to 8 cycles per day were analyzed by linear regression as a function of age. A two-way analysis of variance for subjects classified in four age groups tested for any variance transposition from the circadian (about-daily) to the infradian (frequency lower than one cycle per day) and/or to the ultradian (frequency higher than one cycle per day) domain.
  
  
  RESULTS
  The decreasing circadian BP amplitude with age is accompanied by an increase in infradian and ultradian prominence. The day-to-day variability in circadian characteristics also increases with age.
  
  
  CONCLUSIONS
  A variance transposition from the circadian to the neighboring ultradian and infradian domains characterizes the elderly human BP chronome, as a new, technically implementable biological, rather than chronological, gauge of human aging.
authors.affiliation: Tyumen Medical Academy, Russia.
authors.forename: D
authors.initials: D
authors.lastname: Gubin
authors.forename: G
authors.initials: G
authors.lastname: Cornélissen
authors.forename: F
authors.initials: F
authors.lastname: Halberg
authors.forename: G
authors.initials: G
authors.lastname: Gubin
authors.forename: K
authors.initials: K
authors.lastname: Uezono
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure; D002648:Child; D002940:Circadian Rhythm; D006801:Humans; D008875:Middle Aged