Medico-genetic and cytogenetic study of a family with high predisposition to malignant disease in gastro-intestinal tract.
In a family consisting of 48 persons with high predisposition to familial stomach cancer (SCr), SCr was diagnosed in 8 persons (I-2; II-1,3,4; III-1,2,3,4). Moreover, one woman (III-8) had bilateral breast cancer and two (proband: IV-1 and her father's cousin: III-10) chronic gastritis. The proband, her father's cousin, his sister (III-11) and the proband's sister (IV-2) were examined clinically and cytogenetically (with the metaphase method on blood lymphocytes with G-banding of chromosome 21: (p12-pter) in 100% of cells on the basis of chromosomal instability; besides, the complex translocation in chromosome 2 in 4% of cells and the increase of q-arm of chromosome 21 was found in 2% of cells. The proband's sister (IV-2) had 3% of cells with polyploidy, the del 1 (p34-pter) in 1% of cells and the del 7 (p21-pter) in 4% of cells. The cytogenetic examination of the proband's uncle (III-10), carried out 3 times, revealed the case of the proband, endomitosis in 2% of cells, polyploidy in 2% of cells and hyperaneuploidy in 4% of cells. His sister (III-11) had 4% of cells with endomitosis, 3% of cells with chromosome and chromatid breaches, an increase of the p-arm of chromosome 21 in 100% of cells and the loss of 7p in 2% of cells. The nature of the phenomenon in chromosome 21 and the translocations in the members of this family is here discussed. The cytogenetic examination is currently ongoing.
Monakhov
A S
AS
N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.
Gulyaev
A V
AV
Savochkina
I V
IV
Hanson
K P
KP
D000328:Adult; D000368:Aged; D002891:Chromosomes, Human, Pair 21; D004198:Disease Susceptibility; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012307:Risk Factors; D014178:Translocation, Genetic
D005819:Genetic Markers