title: Clinical significance of cytogenetic abnormalities in uterine myomas.
abstract: OBJECTIVE
  To investigate the clinical characteristics of uterine myomas with cytogenetic rearrangements.
  
  
  METHODS
  Comparative study of myomas with normal and abnormal karyotype.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Premenopausal, GnRH-agonist (GnRH-a) treated and menopausal patients.
  
  
  METHODS
  Myomectomy or hysterectomy.
  
  
  METHODS
  Karyotype analysis and clinical characteristics.
  
  
  RESULTS
  Clonal abnormalities occurred in 29% of uterine myomas but were not related to the age of the patient or, in untreated menopausal patients, to the size of the myoma. In GnRH-a treated and menopausal women, 48% of the myomas larger than 4 cm were associated with clonal abnormalities. Submucous myomas had significantly fewer clonal abnormalities (12%) than subserosal (29%) or intramural myomas (35%).
  
  
  CONCLUSIONS
  The data support the hypothesis that cytogenetic rearrangements in uterine myomas are associated with loss of steroid hormones dependency and alter the growth potential of the tumor.
authors.affiliation: University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Brosens
authors.forename: J
authors.initials: J
authors.lastname: Deprest
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D002869:Chromosome Aberrations / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D025063:Chromosome Disorders; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007621:Karyotyping; D018231:Leiomyomatosis / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D017329:Triptorelin Pamoate / Q000627:therapeutic use; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017329:Triptorelin Pamoate