title: Islet-cell hyperplasia causing hyperinsulinemic hypoglycemia in an adult.
abstract: We report a patient, a 23-year-old man, who had clinical and laboratory findings suggestive of insulinoma. Although imaging studies did not reveal any tumors in the pancreas, distal pancreatectomy was performed because the possibility of small insulinoma could not be completely excluded. Grossly, the surgically removed pancreas did not reveal any tumors. Microscopically, the pancreas exhibited islet cell hyperplasia and nesidioblastosis. To our knowledge, this is the first authentic reported case of islet-cell hyperplasia occurring in a Japanese adult.
authors.affiliation: Department of Internal Medicine, Uwajima City Hospital, Ehime, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: K
authors.initials: K
authors.lastname: Kurihara
authors.forename: T
authors.initials: T
authors.lastname: Kondoh
authors.forename: T
authors.initials: T
authors.lastname: Okanoue
authors.forename: T
authors.initials: T
authors.lastname: Chiba
mesh_terms: D000328:Adult; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications* / Q000209:etiology; D006965:Hyperplasia / Q000150:complications; D007003:Hypoglycemia / Q000209:etiology*; D007515:Islets of Langerhans / Q000473:pathology*; D008297:Male; D010182:Pancreatic Diseases / Q000473:pathology* / Q000601:surgery