Protective effect of passive immunization against TNF-alpha in mice infected with Sendai virus.
TNF-alpha has been reported to be induced in mice infected with Sendai virus. We evaluated the role of TNF-alpha in the virus infection. TNF-alpha was induced locally in proportion to virus titers in the lung. The activity was correlated with suppression of body weight gain. Passive immunization against TNF-alpha improved body weight gain and ameliorated pneumonic lesions in infected mice, and prevented them from lethal infection, but lung virus induced emaciation, pneumonic lesions and death were mediated by TNF-alpha.
Iwai
H
H
Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.
Morioka
A
A
Shoya
Y
Y
Obata
Y
Y
Goto
M
M
Kirisawa
R
R
Okada
H
H
Yoshino
T
T
D000818:Animals; D001835:Body Weight / Q000276:immunology; D005260:Female; D007116:Immunization, Passive; D008171:Lung Diseases / Q000276:immunology / Q000401:mortality / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D011817:Rabbits; D018108:Respirovirus / Q000276:immunology*; D010253:Respirovirus Infections / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000276:immunology* / Q000502:physiology
D014409:Tumor Necrosis Factor-alpha