title: [Molecular biological and biochemical features of breast cancer].
abstract: Some molecular genetic and biochemical features of malignant breast tumors were studied in females living in North-Western Russia. ERBB-2 oncogene amplification frequently (25%) occurred and was associated with poor outcomes. The frequency of C-MYC extra copies was lower (3%) than that in Europe and the USA. Deletions at chromosome 17p were associated with ERBB-2 amplification and the lack of nodal involvement. Moreover, it is concluded that endogenous hormonal and metabolic parameters, as well their changes due to some environmental factors (smoking), plays a great role in the modification both of breast cancer risk and autocrine-paracrine relationships in the very tumor tissue and of the hormone sensitivity of the latter.
authors.forename: K P
authors.initials: KP
authors.lastname: Khanson
authors.forename: L M
authors.initials: LM
authors.lastname: Bershteĭn
authors.forename: E N
authors.initials: EN
authors.lastname: Imianitov
authors.forename: E V
authors.initials: EV
authors.lastname: Tsyrlina
authors.forename: V F
authors.initials: VF
authors.lastname: Semiglasov
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry* / Q000235:genetics* / Q000473:pathology; D002455:Cell Division / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005784:Gene Amplification / Q000235:genetics; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm
vernacular_title: Molekuliarno-biologicheskie i biokhmicheskie osobennosti raka molochnoĭ zhelezy.