Fixed drug eruption due to amlexanox.
A 23-year-old woman developed allergic rhinitis in 1993. Her doctor prescribed for her Solfa (amlexanox 25 mg) and Lysozymen 90 (lysozyme chloride 90 mg) tablets. She took the tablets occasionally, whenever she developed allergic rhinitis. She noticed a macular erythema of about 3.5 cm wide on her buttocks in 1994, about 1 year after the initial prescription. We conducted a series of tests with the tablets. On patch testing, the patient had a positive reaction to Solfa 50% pet. on the eruptive area, but no such reaction on the non-eruptive area. Furthermore, on patch testing, she had no reaction to Lysozymen 90, 50% pet. on either the eruptive or the non-eruptive area. We also used open application test with Solfa 50% pet. to confirm the cause of her erythema.
Sugiura
M
M
Department of Dermatology, Daiko Medical Center, Nagoya University Hospital, Japan.
Hayakawa
R
R
Osada
T
T
D000328:Adult; D000368:Aged; D000631:Aminopyridines / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use; D018926:Anti-Allergic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy
D000631:Aminopyridines; D018926:Anti-Allergic Agents; C045742:amlexanox