title: Bath-PUVA therapy in three patients with scleredema adultorum.
abstract: BACKGROUND
  Scleredema adultorum (SA) is a rare connective tissue disorder for which no treatment has proven to be effective.
  
  
  OBJECTIVE
  Our purpose was to determine the effect of bath-PUVA therapy on SA.
  
  
  METHODS
  Three patients were treated. Clinical evaluation of skin induration and thickness as well as ultrasonography were performed at baseline and after treatment.
  
  
  RESULTS
  All three patients showed substantial clinical improvement with bath-PUVA therapy (median of 59 treatments and a cumulative UVA dose of 245.7 J/cm2). Ultrasonography showed significant reduction in both skin thickness and density.
  
  
  CONCLUSIONS
  Bath-PUVA therapy appears to be effective in the treatment of SA.
authors.affiliation: Department of Dermatology, University of Cologne, Germany.
authors.forename: C M
authors.initials: CM
authors.lastname: Hager
authors.forename: H A
authors.initials: HA
authors.lastname: Sobhi
authors.forename: N
authors.initials: N
authors.lastname: Hunzelmann
authors.forename: C
authors.initials: C
authors.lastname: Wickenhauser
authors.forename: R
authors.initials: R
authors.lastname: Scharenberg
authors.forename: T
authors.initials: T
authors.lastname: Krieg
authors.forename: K
authors.initials: K
authors.lastname: Scharffetter-Kochanek
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D011879:Radiotherapy Dosage; D012592:Scleredema Adultorum / Q000188:drug therapy* / Q000473:pathology