title: Sonographic detection of focal changes in the liver hilus in patients receiving corticosteroid therapy.
abstract: OBJECTIVE
  While diffuse deposition of fat may occur with corticosteroid (CS) administration both in the liver and in other organs, comparatively little is known about focal changes in the liver under corticosteroid medication. Therefore, we evaluated pattern and extent of focal hepatic steatosis by ultrasound (US) in patients receiving corticosteroids.
  
  
  METHODS
  93 patients with known inflammatory bowel disease (IBD) received corticosteroids during a period of at least six weeks prior to the ultrasound examination and 28 IBD-patients had no corticosteroids within the last three years. 13 additional patients received corticosteroids for other reasons than IBD for > 1 year. 80 healthy volunteers served as controls. Focal changes of the liver as assessed by high resolution ultrasound (Acuson 128, 3.5 and 5 MHz) were defined as areas of brighter echogenicity compared to the general aspect of the liver. The size of the hyperechoic areas was documented (photoprint).
  
  
  RESULTS
  40/93 IBD-patients with corticosteroids (43%) had definite areas of brighter echos in the hilus region of the liver. In IBD-patients without corticosteroids only one patient showed a focal brighter echogenicity, whereas in the non-IBD group with corticosteroids 8/13 had focal lesions (62%). In the control group only four healthy subjects showed brighter areas (5%).
  
  
  CONCLUSIONS
  Bright focal areas in the liver hilus occur in > 40% of IBD-patients during corticosteroid medication. This phenomenon occurs in IBD-patients as frequently and as intense as in other patients with longstanding corticosteroid therapy. There is a hilar area of the liver with typical size and location which reacts to corticosteroid administration with hyperechoic reflexes at ultrasound investigation. This is important to know when it comes to the differential diagnosis of focal changes.
authors.affiliation: Medizinische Klinik II, J.-W.-Goethe-Universitätsklinik, Frankfurt, Germany.
authors.forename: C F
authors.initials: CF
authors.lastname: Dietrich
authors.forename: H
authors.initials: H
authors.lastname: Schall
authors.forename: J
authors.initials: J
authors.lastname: Kirchner
authors.forename: H
authors.initials: H
authors.lastname: Seifert
authors.forename: G
authors.initials: G
authors.lastname: Herrmann
authors.forename: W F
authors.initials: WF
authors.lastname: Caspary
authors.forename: B
authors.initials: B
authors.lastname: Lembcke
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000000981:diagnostic imaging*; D005234:Fatty Liver / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D008099:Liver / Q000000981:diagnostic imaging; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D000305:Adrenal Cortex Hormones