Effects of cadmium on haemopoiesis in irradiated and non-irradiated mice: 2. Relationship to the number of circulating blood cells and haemopoiesis.
The effect of administration of cadmium alone in non-irradiated mice as well as the effect of pre-irradiation administration of cadmium on the reparation processes of haemopoiesis were investigated in mice irradiated by a dose of 7.5 Gy. The pre-irradiation administration of cadmium accelerated the reparation processes in the bone marrow and spleen as well as the number of leukocytes and thrombocytes in the peripheral blood. The administration of cadmium alone caused a temporary weight decrease of the thymus and reduced number of erythrocytes, reticulocytes and haemoglobin values in the peripheral blood. The temporary rapid increase in the number of leukocytes on the 21st day after cadmium administration was investigated.
Macková
N O
NO
Department of Cellular and Molecular Biology, Faculty of Sciences, Safárik University, Moyzesova, Kosice, Slovak Republic.
Leníková
S
S
Fedorocko
P
P
Brezáni
P
P
Fedorocková
A
A
D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects* / Q000528:radiation effects*; D001773:Blood Cells / Q000187:drug effects* / Q000528:radiation effects*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000528:radiation effects; D002104:Cadmium / Q000494:pharmacology*; D005260:Female; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects*; D051379:Mice; D008813:Mice, Inbred ICR; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects
D002104:Cadmium