Unchanged density of caudate nucleus dopamine uptake sites in depressed suicide victims.
In depressive states, theories concerning serotonin and norepinephrine have been dominating, but there are several lines of evidence indicating the involvement of the dopamine system as well, especially in suicidal depression. In this post-mortem study, the binding of the ligand [3H]WIN 35,428 to dopamine uptake sites in the caudate nucleus was investigated in 13 depressed suicide victims and 19 controls. There were no differences in Bmax or Kd between the suicide group and controls. Subdividing the suicide group into subgroups regarding the presence of major depression, antidepressant medication and suicide method, respectively, did not yield any differences. Previous findings regarding reduced CSF HVA in suicidal depression and indications of striatal dopaminergic biochemical and receptor changes in depression seem, according to the present study, not to be reflected by alterations in density or affinity of dopamine uptake sites in depressed suicide victims.
Allard
P
P
Department of Psychiatry, Umeå University, Sweden.
Norlén
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002421:Caudate Nucleus / Q000378:metabolism*; D003042:Cocaine / Q000031:analogs & derivatives; D003866:Depressive Disorder / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D011954:Receptors, Dopamine / Q000378:metabolism*; D013405:Suicide
D018765:Dopamine Uptake Inhibitors; D008024:Ligands; D011954:Receptors, Dopamine; C021279:(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester; D003042:Cocaine; D004298:Dopamine