Evaluation of acceleration plethysmograms in dermatology--efficacy of lipo PGE1 preparations against herpes zoster and neuralgia following herpes.
Reports published in recent years indicate that administration of lipo PGE1 is effective against herpes zoster and neuralgia following herpes. However, there are presently no standards to objectively assess efficacy. We therefore looked into the possibility of achieving this goal by using an acceleration plethysmograph. The results showed a significant difference in the rate of change of pulse waves after initiation of drip infusion as compared to before drip infusion among the effective group, the control group, and the non-effective group. This method appears to be useful to objectively assess both the analgesic effects of lipo PGE1 and the efficacy of drugs in general, based on data analysis. Our results suggest that investigations using this method may be able to predict the therapeutic effects of vasodilators and analyze hemodynamic disorders of the skin.
Okuda
T
T
Department of Dermatology, Tokyo Medical College, Japan.
Oh-i
T
T
Koga
M
M
D000527:Alprostadil / Q000008:administration & dosage*; D003880:Dermatology / Q000295:instrumentation*; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D006562:Herpes Zoster / Q000150:complications / Q000517:prevention & control*; D006801:Humans; D007262:Infusions, Intravenous; D009437:Neuralgia / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D010147:Pain Measurement; D010991:Plethysmography / Q000295:instrumentation*; D012680:Sensitivity and Specificity; D012867:Skin / Q000098:blood supply; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D000527:Alprostadil