Agrin and acetylcholine receptor distribution following electrical stimulation.
Electrical stimulation is a therapeutic modality available for the preservation of muscle function following peripheral nerve injury. Agrin, a synaptic basal lamina protein, induces accumulation of acetylcholine receptors (AChRs) and other molecules at the neuromuscular junction. Electrical stimulation of denervated muscle does not alter agrin and AChR distribution at abandoned synaptic sites, supporting the hypothesis that the existing aggregation of synaptic molecules, which may be necessary for successful reinnervation, is unaltered by electrical stimulation of denervated muscle.
Stanco
A M
AM
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160-7400, USA.
Werle
M J
MJ
D000818:Animals; D004558:Electric Stimulation; D008297:Male; D009045:Motor Endplate / Q000502:physiology; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D011894:Rana pipiens; D011950:Receptors, Cholinergic / Q000378:metabolism*; D017978:Receptors, Growth Factor / Q000378:metabolism*
D011950:Receptors, Cholinergic; D017978:Receptors, Growth Factor; C080030:agrin receptor