How do G-proteins stay at the plasma membrane?
G-protein alpha-subunits are modified by combinations of fatty acyl groups. G-protein gamma-subunits are isoprenylated. These modifications play central roles in membrane association of the G-proteins. Attachment of long-chain fatty acyl chains to G-protein alpha-subunits via a thioester linkage allows the possibility of dynamic regulation of membrane attachment and function.
Milligan
G
G
Molecular Pharmacology Group, University of Glasgow, U.K.
Grassie
M A
MA
D000215:Acylation; D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008969:Molecular Sequence Data; D010169:Palmitic Acids / Q000378:metabolism; D017368:Protein Prenylation; D013379:Substrate Specificity
D010169:Palmitic Acids; D019204:GTP-Binding Proteins