title: [The selective inhibition of cyclooxygenase isoforms: a new approach to the search for effective and safe nonsteroidal anti-inflammatory drug agents].
abstract: The author submits present-day data on mechanisms of action and clinical application of new drug preparations, NSAID, derivatives of enolic acid of the oxicam class, movalis, as one of their number (meloxicam, international name), of Boehringer Ingelheim (Germany). Clinical and pharmacological value is discussed of selective blockade of cyclogenase isoenzymes (COX)--COX1 and COX2 in the antiinflammatory effect and development of unfavourable side-effects.
authors.forename: A P
authors.initials: AP
authors.lastname: Viktorov
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000145:classification / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000145:classification / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008297:Male; D000077239:Meloxicam; D008875:Middle Aged; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013843:Thiazines / Q000009:adverse effects / Q000145:classification / Q000493:pharmacokinetics / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects / Q000145:classification / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D013843:Thiazines; D013844:Thiazoles; D011451:Prostaglandin-Endoperoxide Synthases; D000077239:Meloxicam
vernacular_title: Selektivnaia ingibitsiia izoform tsiklooksigenazy: novyĭ podkhod k izyskaniiu éffektivnykh i bezopasnykh nesteroidnykh protivovospalitel'nykh lekarstvennykh sredstv.