[Blood viscosity disorders as an etiopathological factor in sudden deafness].
Because idiopathic sudden deafness is regarded as the result of a cochlear microcirculation disorder, its treatment has been based mainly on vasoactive therapy with little regard for the blood-flow conditions produced by these circumstances. In a group of 16 patients with sudden-onset deafness, we determined blood viscosity at different shear rates, as well as erythrocyte aggregability, deformability, and filterability, and other potentially influential parameters, such as hematobrit, fibrinogen, and leukocyte and platelet count. These values correlated with hearing loss and average recovery after conventional treatment. Our results showed a trend to high blood viscosity in patients in relation to a control group of persons with normal hearing, with a notorious increase in aggregability, which correlated significantly with recovery of hearing capacity, and a decrease in blood filterability, which correlated with average hearing loss. This suggests a potential etiopathogenic mechanism of the disease and an alternative treatment complementary to current treatment.
García Callejo
F J
FJ
Servicio de ORL, Hospital Clínico Universitario, Valencia.
Velert Vila
M M
MM
Orts Alborch
M H
MH
Pardo Mateu
L
L
Monzó Gandía
R
R
Marco Algarra
J
J
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001809:Blood Viscosity; D003051:Cochlea / Q000098:blood supply / Q000503:physiopathology; D004903:Erythrocyte Aggregation / Q000150:complications* / Q000175:diagnosis; D003639:Hearing Loss, Sudden / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008833:Microcirculation; D009553:Nimodipine / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use; D014803:Vitamin B Complex / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D014665:Vasodilator Agents; D014803:Vitamin B Complex; D009553:Nimodipine; D008775:Methylprednisolone
Trastornos en la viscosidad sanguínea como factor etiopatogénico en la sordera brusca.