Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania.
Leishmania exploits several strategies to survive within the phagolysosome of vertebrate macrophages and be transmitted by sand fly vectors. Recent advances in functional genetic analysis provide a new avenue for identifying genes implicated in the infectious cycle of the parasite, such as those necessary for the synthesis and expression of the key surface glycoconjugate, lipophosphoglycan (LPG).
Beverley
S M
SM
Dept of Molecular Microbiology, Washington University Medical School, St Louis, MO 63110, USA. beverley@borcim.wustl.edu
Turco
S J
SJ
D000818:Animals; D002240:Carbohydrate Sequence; D017125:Genes, Protozoan; D006028:Glycosphingolipids / Q000032:analysis / Q000235:genetics*; D007891:Leishmania / Q000737:chemistry / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity*; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013329:Structure-Activity Relationship; D014774:Virulence / Q000235:genetics*
D006028:Glycosphingolipids; C008290:lipophosphonoglycan