Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan. Short communication.
We report -108Met/Val polymorphism of the COMT gene in Japanese patients with Parkinson's disease (PD). The allele frequency for -108Val was higher in PD patients compared with controls, although the differences did not reach the statistical significance. However, the frequency of -108Val homozygotes was significantly higher in PD patients (56.8%) than in control subjects (44.2%), and heterozygotes of -108Met/Val were less in PD. COMT gene polymorphism may constitute a genetic risk factor for PD among Japanese.
Yoritaka
A
A
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Hattori
N
N
Yoshino
H
H
Mizuno
Y
Y
D000368:Aged; D000483:Alleles; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic
D002394:Catechol O-Methyltransferase