Lysine clonixinate vs. paracetamol/codeine in postepisiotomy pain.
This study was conducted to compare the analgesic action of Lysine Clonixinate (LC) vs Paracetamol/Codeine association (PC) in the treatment of postepisiotomy pain in primiparae women: 131 primiparous patients with moderate-to-severe postepisiotomy pain were enrolled in a double blind dummy design study and randomly allocated to either treatment with fixed doses of LC 125 mg or Paracetamol 500 mg+Codeine 30 mg 6 qh during 24 hours. Intensity of spontaneous pain and pain on walking was assessed according to a visual analog scale (VAS) and patient's assessment before receiving treatment and after 1, 2, 6 and 24 hours. Intensity of spontaneous pain was reduced in 24 hours from 4.28 +/- 2.11 to 1.73 +/- 1.46 (P < 0.0001) in the LC group and from 4.78 +/- 2.08 to 1.90 +/- 1.72 in the PC-treated group (p < 0.0001); with no significant differences between treatments. 54% of the patients treated with LC and 55% of those receiving PC showed onset of analgesic action 30 minutes following dose administration. Patient's final global assessment revealed that 95% of LC-treated patients and 96% of the PC group showed total or partial pain relief during the first treatment day. No sleep disturbances were seen during the night in 75% of patients. Only one patient receiving LC showed nausea not requiring treatment discontinuation. It is concluded that both treatments are equally effective to relieve moderate-to-severe postepisiotomy pain.
De los Santos
A R
AR
School of Medicine, Department of Medicine, Universidad de Buenos Aires, Argentina.
Martí
M I
MI
Espinosa
D
D
Di Girolamo
G
G
Vinacur
J C
JC
Casadei
A
A
D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D000704:Analysis of Variance; D003002:Clonixin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003061:Codeine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004841:Episiotomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D013997:Time Factors
D000700:Analgesics; C089163:lysine clonixinate; D000082:Acetaminophen; D008239:Lysine; D003061:Codeine; D003002:Clonixin