title: Primary non-Hodgkin's lymphoma of the lung presenting as bronchiolitis obliterans organizing pneumonia.
abstract: A 44-year-old man presented with fever, dyspnea, and bilateral cavitary lung lesions. Following percutaneous transthoracic CT guided needle biopsy of the lung, a diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP) was made and the patient was treated with corticosteroids. Despite a good initial response he developed new lung lesions within six months, associated with a lack of response to corticosteroids. Due to further deterioration and the development of Guillian-Barre' syndrome an open lung biopsy was performed and revealed T-cell rich, B-cell non Hodgkin's lymphoma with BOOP. We suggest that BOOP may be the presenting manifestation of primary lung lymphoma. We recommend that when BOOP has an atypical course or does not respond to corticosteroids open lung biopsy should be performed in order to exclude pulmonary lymphoma.
authors.affiliation: Department of Medicine, Hadassah University Hospital, Hebrew University Medical School, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Safadi
authors.forename: N
authors.initials: N
authors.lastname: Berkman
authors.forename: Y S
authors.initials: YS
authors.lastname: Haviv
authors.forename: A
authors.initials: A
authors.lastname: Ben-Yehuda
authors.forename: G
authors.initials: G
authors.lastname: Amir
authors.forename: Y
authors.initials: Y
authors.lastname: Naparstek
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D018549:Cryptogenic Organizing Pneumonia / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D008297:Male