Treatment of vitamin D deficient osteomalacia may unmask autonomous hyperparathyroidism.
Two cases of vitamin D deficient osteomalacia with secondary hyperparathyroidism are presented. In both cases treatment with vitamin D replacement therapy resulted in elevated calcium levels and a failure of parathormone levels to normalise, indicating autonomous parathyroid activity. Subsequent surgery in one case resulted in removal of a parathyroid adenoma. The importance of osteomalacia and its complications are discussed.
Taylor
A V
AV
Department of Endocrinology, Charing Cross Hospital, London, UK.
Wise
P H
PH
D000328:Adult; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D010018:Osteomalacia / Q000188:drug therapy / Q000209:etiology*; D010281:Parathyroid Hormone / Q000097:blood; D014807:Vitamin D / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications*
D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium