The histidin-rich glycoprotein Pro186/Ser polymorphism is not related to myocardial infarction in the ECTIM study.
The histidin-rich glycoprotein (HRG) may contribute to coronary heart disease as a consequence of its possible thrombophilic properties. To test this hypothesis we have investigated the Pro186/Ser polymorphism of the HRG gene, which is known to strongly affect plasma HRG levels, in a large multicenter case-control study of myocardial infarction (MI). The results failed to demonstrate any association between the polymorphism and MI or angiographically assessed coronary stenosis.
Herrmann
S M
SM
Institut National de la Santé et de la Recherche Médicale SC7, Paris, France.
Poirier
O
O
Nicaud
V
V
Ruidavets
J B
JB
Evans
A
A
Arveiler
D
D
Luc
G
G
Bara
L
L
Cambien
F
F
D000328:Adult; D000483:Alleles; D001798:Blood Proteins / Q000235:genetics; D016022:Case-Control Studies; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D000099053:Histidine-Rich Glycoprotein
D001798:Blood Proteins; D006023:Glycoproteins; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein