title: Characteristics of chronic MS lesions in the cerebrum, brainstem, spinal cord, and optic nerve on T1-weighted MRI.
abstract: We analyzed the prevalence of severely hypointense lesions on T1-weighted MRI in the brainstem, spinal cord, and optic nerve from 65 patients with MS. About half of 1,274 supratentorial lesions were classified as severely hypointense. Severe hypointensity was not seen in the optic nerve and spinal cord, and in only one of 168 chronic brainstem lesions. Tissue destruction in the brainstem, spinal cord, and optic nerve of MS patients does not usually result in severely hypointense lesions.
authors.affiliation: Department of Neurology, Klinikum Mannheim, University of Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Gass
authors.forename: M
authors.initials: M
authors.lastname: Filippi
authors.forename: M E
authors.initials: ME
authors.lastname: Rodegher
authors.forename: A
authors.initials: A
authors.lastname: Schwartz
authors.forename: G
authors.initials: G
authors.lastname: Comi
authors.forename: M G
authors.initials: MG
authors.lastname: Hennerici
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*