Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation.
To assess the inter-study variability of a recently published unsupervised segmentation method (Magn. Reson. Med. 1997;37:84-93), 14 brain MR studies were performed in five normal subjects. Standard deviations for absolute and fractional volumes of intracranial compartments, which reflect the experimental variability, were smaller than 16.5 ml and 1.1%, respectively. By comparing the experimental component of the variability with the variability observed in our reference database, an estimate of the biological variability of the intracranial fractional volumes in the database population was obtained.
Alfano
B
B
Department of Radiology, CNR-Nuclear Medicine Center, University Federico II, Napoli, Italy.
Quarantelli
M
M
Brunetti
A
A
Larobina
M
M
Covelli
E M
EM
Tedeschi
E
E
Salvatore
M
M
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology; D001284:Atrophy; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology; D002555:Cerebrospinal Fluid; D019992:Databases as Topic; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology; D019047:Phantoms, Imaging; D012044:Regression Analysis; D015203:Reproducibility of Results; D012189:Retrospective Studies