title: [The effect of the heptoprotective agent LIV 52 on liver damage].
abstract: BACKGROUND
  The action of hepatoprotective drugs is a steady subject of discussions. Despite the equivocal character of action hepatoprotective drugs are used, despite the fact that the effect is partly a placebo effect. In the literature are reports on preparation LIV 52 which is a mixture of substances of plant origin and improves the subjective complaints of patients as well as the objective condition of patients with liver disease.
  
  
  RESULTS
  The effect of preparation LIV 52 was investigated in a retrospective study in 19 patients with liver damage. In the majority liver damage caused by alcohol was involved, steatosis and persisting hepatitis without the finding of chronic hepatitis B and C. The authors investigated biochemical parameters (bilirubin, ALT, AST, ALP, TZR, cholesterol). The size of the liver was assessed by ultrasonography and the subjective status of the patients was recorded. Within one year of administration of the preparation subjective improvement occurred, hepatomegaly diminished and the activity of aminotransferases declined.
  
  
  CONCLUSIONS
  Administration of LIV 52 can improve the subjective condition and clinical parameters in patients with liver damage, in particular in alcoholic liver damage and in steatosis. The effect is certainly due also to better motivation on the patients part, better lifestyle and dietary measures. After one year of treatment no undesirable side-effects were detected.
authors.affiliation: I. interní klinika 1, LF UK a VFN, Praha.
authors.forename: M
authors.initials: M
authors.lastname: Kaláb
authors.forename: T
authors.initials: T
authors.lastname: Krechler
mesh_terms: D000328:Adult; D000368:Aged; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D012189:Retrospective Studies
chemical_list: D004338:Drug Combinations; D010936:Plant Extracts; C002614:Liv 52
vernacular_title: Vliv hepatoprotektiva LIV 52 na jaterní poskozeni.