Age-associated mosaicism and polyploidy in Down's syndrome.
Age-related increases in the frequencies of cells with chromosome 21 loss and of polyploid cells were documented in short-term peripheral blood lymphocyte cultures from 54 patients with Down's syndrome (DS), ages 0 to 48 years. The polyploid data, together with previous work from this laboratory with non-DS subjects, suggest that this may be a useful indicator of aging in lymphocytes.
Borsatto
B
B
Departamento de Morfologia, Disciplina de Genética, UNIFESP-Escola Paulista de Medicina, Sao Paulo, Brazil.
Smith
M de A
Mde A
Garcez
E M
EM
Peres
C A
CA
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D011123:Polyploidy