[Fatal outcome in allopurinol hypersensitivity syndrome].
A 76 year-old otherwise healthy man was treated with allopurinol after a single episode of gout. He developed allopurinol hypersensitivity syndrome with epidermal necrolysis, dermal vasculitis, impaired renal function, fever, gastrointestinal bleeding, and possibly pulmonary vasculitis. The outcome was lethal. Controlling allopurinol therapy according to renal function is emphasized.
Kluger
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E
Odense Universitetshospital, medicinsk afdeling C.
D000368:Aged; D000493:Allopurinol / Q000009:adverse effects* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology*; D017809:Fatal Outcome; D006073:Gout / Q000188:drug therapy* / Q000276:immunology; D006074:Gout Suppressants / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000209:etiology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology
D006074:Gout Suppressants; D000493:Allopurinol
Letalt forløbende allopurinolhypersensitivitetssyndrom.