Matrix metalloproteinases and diseases of the CNS.
Matrix metalloproteinases (MMPs) are increasingly being implicated in the pathogenesis of several CNS diseases. In multiple sclerosis, MMPs could be responsible for the influx of inflammatory mononuclear cells into the CNS, contribute to myelin destruction and disrupt the integrity of the blood-brain barrier; in Alzheimer's disease, MMPs might mediate the deposition of amyloid beta-proteins; and MMPs are known to contribute to the invasiveness of malignant glioma cells and might regulate their angiogenic capacity. Nonetheless, MMPs could also have beneficial roles in recovery from CNS injury.Therefore, both the identity of the MMP and its cellular origin could determine whether disease pathogenesis or regeneration occurs, and thus synthetic MMP inhibitors might be valuable for treating some CNS diseases.
Yong
V W
VW
Dept of Oncology, University of Calgary, Alberta, Canada.
Krekoski
C A
CA
Forsyth
P A
PA
Bell
R
R
Edwards
D R
DR
D000818:Animals; D002493:Central Nervous System Diseases / Q000201:enzymology* / Q000473:pathology; D005109:Extracellular Matrix / Q000201:enzymology*; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism*
D008666:Metalloendopeptidases