An integrated genetic and man-mouse comparative map of the DXHXS674-Pdha1 region of the mouse X chromosome.
The genes for ocular albinisim type 1 (OA1) and the Xenopus laevis-like apical protein (APXL) map between amelogenin (AMELX) and the pseudoautosomal boundary in the distal region of the human X chromosome short arm. The mouse homologues, Oa1 and Apxl, have recently been shown to lie proximal to their expected locations on the mouse X chromosome, but their positions with respect to critical gene loci in the vicinity have not been defined. By analyzing recombination events from (Mus musculus x Mus spretus) x M. musculus backcrosses, we have constructed a detailed mouse genetic map that encompasses Oa1, five other genes, and 13 microsatellite loci. The order of genes and evolutionary breakpoints (EB) is defined as centromere-(EB)-(DXHXS674, DXHXS679)-Smcx-(EB)-Oa1-(EB)-Phex (3'-->5')-Pdha1-telomere. Thus Oa1 lies in a region between two previously characterized conserved segments.
Blair
H J
HJ
MRC Mammailan Genetics Unit, Harwell, Oxon, United Kingdom.
Uwechue
I C
IC
Barsh
G S
GS
Rowe
P S
PS
Boyd
Y
Y
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004276:DNA, Satellite; D006801:Humans; D051379:Mice; D011995:Recombination, Genetic; D014960:X Chromosome
D004276:DNA, Satellite