Increased synaptic availability of norepinephrine following desipramine is not essential for increases in GR mRNA. Short communication.
Male Sprague-Dawley rats were treated for 7 days with the norepinephrine (NE) uptake inhibitors desipramine (DMI) or (+)-oxaprotiline or the inactive (-)-enantiomer of oxaprotiline. DMI, as previously reported, significantly increased hippocampal glucocorticoid receptor (GR) mRNA while the equipotent NE uptake inhibitor (+)-oxaprotiline like the inactive (-)-oxaprotiline did not alter hippocampal levels of GR mRNA. The results indicate that an increase in the synaptic availability of NE as a consequence of uptake inhibition is not responsible for the action of DMI on GR gene expression.
Eiring
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A
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA.
Sulser
F
F
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology*; D008297:Male; D008376:Maprotiline / Q000031:analogs & derivatives / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000096:biosynthesis*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*
D018759:Adrenergic Uptake Inhibitors; D000928:Antidepressive Agents; D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D008376:Maprotiline; C027299:hydroxymaprotilin; D003891:Desipramine; D009638:Norepinephrine