[Role of aldose reductase inhibitors in the development of peripheral neuropathy in experimental diabetes].
Streptozotocin-induced diabetes in rats is accompanied by development of diabetic complications such as neuropathies. It was shown that aldose reductase inhibitors (A1-1576, sorbinil and unithiol) administration partially normalized not only polyol pathway. Aldose reductase inhibitors partially restored Na+, K(+)-ATP-ase activity in sciatic nerve of diabetic rats and redox state of nicotinamide adenine dinucleotides. The sorbitol level increases in streptozotocin-diabetic rats as compared to control. Administration of aldose reductase inhibitors to diabetic rats is accompanied by partial reduction of sorbitol level in sciatic nerve. The results obtained confirm the important role of a dose reductase inhibitors, as antidiabetic drugs, in the improvement of diabetic neuropathy.
Kuchmerovskaia
T M
TM
A.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine.
Donchenko
G V
GV
Klimenko
A P
AP
Chichkovskaia
G V
GV
Pakirbaeva
L V
LV
Kozitskiĭ
Z Ia
ZIa
Efimov
A S
AS
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005449:Fluorenes / Q000627:therapeutic use; D005947:Glucose / Q000378:metabolism; D006827:Hydantoins / Q000627:therapeutic use; D007093:Imidazoles / Q000627:therapeutic use; D048289:Imidazolidines; D008297:Male; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014494:Unithiol / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D005449:Fluorenes; D006827:Hydantoins; D007093:Imidazoles; D048289:Imidazolidines; C052241:imirestat; D014494:Unithiol; D009249:NADP; D000449:Aldehyde Reductase; D000254:Sodium-Potassium-Exchanging ATPase; C026411:sorbinil; D005947:Glucose
Rol' ingibitorov al'dozoreduktazy v razvitii perifericheskikh neĭropatiĭ pri éksperimental'nom diabete.