title: [Local injection of cisplatin for vaginal stump recurrence of gynecological malignant tumor].
abstract: Cisplatin (CDDP) has been reported to be a most effective drug for gynecologic cancer. We investigated the efficacy of local injection of CDDP. The subjects are 3 patients with local recurrence of vaginal stump in a gynecologic malignant tumor. CDDP was injected locally in the tumor using a single dose of 10 mg for 5 days. The effects of the therapy were evaluated by cytology, tumor markers, ultrasonography and CT. The results of this therapy were PR in one patient and NC in two patients. One patient with ovarian carcinoma stage III c survived for 11 months following this therapy with CDDP. Her genital bleeding was stopped, and her performance status was improved. In conclusion, it is suggested that this therapy is useful for vaginal recurrence of a gynecologic malignant tumor. We hope that wider use of this method will improve the quality of life for end-stage patients.
authors.affiliation: Dept. of Obstetrics and Gynecology, Senboku Kumiai General Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Igarashi
authors.forename: T
authors.initials: T
authors.lastname: Kushima
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D010051:Ovarian Neoplasms / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000188:drug therapy* / Q000556:secondary*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin