Ileal pouch-anal anastomosis in patients with colorectal cancer: long-term functional and oncologic outcomes.
When colorectal cancer complicates chronic ulcerative colitis or familial adenomatous polyposis, the role of ileal pouch-anal anastomosis is uncertain because of concerns that the procedure may compromise oncologic therapy and that oncologic therapy may compromise ileal pouch-anal anastomosis function.


OBJECTIVE
This study was undertaken to investigate the impact both of ileal pouch-anal anastomosis on cancer outcomes and of cancer treatments on ileal pouch-anal anastomosis function.


METHODS
Of 1,616 patients undergoing ileal pouch-anal anastomosis for chronic ulcerative colitis or familial adenomatous polyposis (1981-1994), 77 patients were identified with adenocarcinoma of the colon (56), rectum (17), or both (4). Data were obtained from an ileal pouch-anal anastomosis registry, case notes, and postal and telephone surveys.


RESULTS
Mean age of the 77 index patients was 37 (range, 13-60) years. Stage distribution was as follows: Stage 0, 9; Stage I, 31; Stage II, 15; Stage III, 22 patients. Twelve patients died with systemic disease (6 with a local component) after a mean follow-up of 6 (range, 2-15) years. Twenty-two patients received adjuvant therapy (chemotherapy, 16; radiotherapy, 2; both, 4 patients). Chemotherapy complications requiring dose reduction or interruption occurred in three (15 percent) patients. One patient developed radiation enteritis (17 percent). Pouch failure occurred in 16 percent of cancer patients, compared with 7 percent for the overall registry. There were no differences between cancer and non-cancer groups in operative complications, median stool frequency, incontinence, pad usage, or pouchitis.


CONCLUSIONS
Although pouch failure is more common, ileal pouch-anal anastomosis can be performed in the setting of colorectal cancer without significant impact on oncologic outcome or long-term ileal pouch-anal anastomosis function.
Radice
E
E
Mayo Clinic and Mayo Foundation, Division of Colon and Rectal Surgery, Rochester, Minnesota 55905, USA.
Nelson
H
H
Devine
R M
RM
Dozois
R R
RR
Nivatvongs
S
S
Pemberton
J H
JH
Wolff
B G
BG
Fozard
B J
BJ
Ilstrup
D
D
D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000150:complications / Q000601:surgery; D003108:Colonic Diseases / Q000150:complications / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D003131:Combined Modality Therapy; D000075202:Contraindications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative; D011878:Radiotherapy / Q000009:adverse effects; D016896:Treatment Outcome