[Use of methotrexate for treatment of corticosteroid-dependent asthma].
We evaluated the effects of methotrexate treatment in 20 subjects (10 men, 10 women) suffering from corticosteroid-dependent asthma. All patients had been treated with 15 mg of prednisone or more per day for at least 3 years before including in the study. Methotrexate (15 mg once weekly) had been given for 9.7 months on average. Oral steroid intake was reduced by 50% in 8 patients and it was possible to discontinue oral corticosteroids in further 6 patients without deterioration of spirometric parameters at the end of the study. Side effects of methotrexate therapy were observed in 40% of patients, and required the discontinuation of treatment in 6 subjects.
Kazimierczak
A
A
I Kliniki Gruźlicy i Chorób Płuc Instytutu, Gruźlicy i Chorób Płuc w Warszawie.
Maziarka
D
D
Skorupa
W
W
Kuś
J
J
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005493:Folic Acid Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage*
D005493:Folic Acid Antagonists; D005938:Glucocorticoids; D011241:Prednisone; D008727:Methotrexate
Zastosowanie metotreksatu w leczeniu kortykozaleznej astmy oskrzelowej.