Synthesis of 5H-dipyrido[1,2-a:2',3'-d]pyrimidin-5-ones as potential antiallergy agents.
A novel synthesis of 5H-dipyrido[1,2-a:2',3'-d]pyrimidin-5-ones is described. The method is based on Ullmann condensation of 2-chloronicotinic acid and its 5-bromo analoguewith 2-aminopyridine 1-oxides, followed by intramolecular cyclization of the resulting 3-carboxy-2,2'-bipyridylamine 1'-oxides with phosphorous.
Rykowski
A
A
Institute of Chemistry, Agricultural and Pedagogical University, Siedlce, Poland.
Pucko
W
W
D018926:Anti-Allergic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
D018926:Anti-Allergic Agents; D011725:Pyridines; D011744:Pyrimidinones