title: Design and preliminary results of an ultrasound applicator for interstitial thermal coagulation.
abstract: The extracorporeal high-intensity focused ultrasound (HIFU) techniques are not still transposable for tumors of the digestive tract because of their locations. This study was designed to evaluate the feasibility of interstitial applicators (3.8 mm O.D.) to comply with this therapeutic lack and to demonstrate the possibility of producing coagulation necrosis by a specially designed probe and with a short exposure time (20 s). The active surface of the applicators consists of plane water-cooled PZT transducers working at 10 or 5 MHz. They were evaluated in terms of acoustic power emitted as a function of the frequency, and applied electrical input (electroacoustic efficiency of 75% at their working frequency) and in vitro and in vivo pig liver tissue destruction. The in vitro and in vivo necroses depth from the applicator surface ranged from 8 to 20 mm. This showed the advantage of a nondivergent source: the pressure decay is only due to the tissue absorption in the Fresnel zone. The lesions dimensions are slightly dependent on perfusion: 8 +/- 2 mm deep in vitro for a 10.7-MHz transducer working at 14 W/cm2 against 10 mm in vivo. Operating at 5 MHz makes it possible to increase the therapeutic heating depth. For example, at a similar close-to-transducer temperature, the 5-MHz applicator induced, at a depth of 10 mm, a temperature elevation of 27 degrees C against 15 degrees C for that working at 10 MHz.
authors.affiliation: INSERM, Unité 281, Lyon, France. lafon@lyon151.inserm.fr
authors.forename: C
authors.initials: C
authors.lastname: Lafon
authors.forename: J Y
authors.initials: JY
authors.lastname: Chapelon
authors.forename: F
authors.initials: F
authors.lastname: Prat
authors.forename: F
authors.initials: F
authors.lastname: Gorry
authors.forename: J
authors.initials: J
authors.lastname: Margonari
authors.forename: Y
authors.initials: Y
authors.lastname: Theillère
authors.forename: D
authors.initials: D
authors.lastname: Cathignol
mesh_terms: D000818:Animals; D004564:Electrocoagulation / Q000295:instrumentation*; D004867:Equipment Design; D005240:Feasibility Studies; D006979:Hyperthermia, Induced; D066298:In Vitro Techniques; D008099:Liver / Q000293:injuries / Q000473:pathology; D008297:Male; D009336:Necrosis; D013552:Swine; D014159:Transducers; D014465:Ultrasonics