[Effects, on early auditory evoked potentials, of road traffic noise, of benzodiazepine and their combination].
In this study, 30 young men and 30 young women (with the same proportion of anxious persons in each group) were submitted, in random order, to: i) a road traffic noise of 75 dBA for 15 min; ii) this same noise for 15 min, having ingested 0.25 mg of alprazolam (Xanax*) 1 h before; iii) uniquely 0.25 mg of alprazolam. The auditory brainstem evoked potentials (ABEP) were taken before and after exposure to noise (for the non-noise case, we respected the same time schedule). The alprazolam had an effect on the cochlea and can be considered as a noise adaptation factor on the auditory pathways explored by the ABEP.
Morizot-Martinet
S
S
Laboratoire d'ergonomie, de psychophysiologie, de psychosociologie et de santé au travail (LEPPST), faculté des sciences de la vie, université de Bourgogne, Dijon.
Petiot
J C
JC
Smolik
H J
HJ
Trapet
P
P
Gisselmann
A
A
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000525:Alprazolam / Q000494:pharmacology*; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy; D001336:Automobiles; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009624:Noise, Transportation; D012737:Sex Factors; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000525:Alprazolam
Effects, sur les potentiels évoqués auditifs précoces, d'un bruit de trafic routier, d'une benzodiazépine et de leur conjugaison.