[The effect of catecholamines on the luminol-dependent chemiluminescence of rat polymorphonuclear leukocytes].
The effects of catecholamines on reactive oxygen species (ROS) generation by polymorphonuclear leucocytes were studied using chemiluminescence (CL). It has been found that catecholamines in 10(-9)-10(-10) M concentration range are able to increase reactive oxygen species generation. Within the micromolar concentration range (10(-6)-10(-5) M) cetacholamines (CA) strongly suppress CL intensity and ROS production. The efficiency of inhibitory action of CA: noradrenaline > adrenaline > dopamine > L-DOPA correspond to their redox properties. A conclusion is made that peroxidase is one of the main targets of CA effect.
Potselueva
M M
MM
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
Marinov
B S
BS
Pustovidko
A V
AV
Kudzina
L Iu
LIu
Evtodienko
Iu V
IuV
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008163:Luminescent Measurements; D008165:Luminol; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
D002395:Catecholamines; D017382:Reactive Oxygen Species; D008165:Luminol
Vliianie katekholaminov na liuminolzavisimuiu khemiliuminestsentsiiu polimorfnoiadernykh leĭkotsitov krysy.