[The effect of an acetylcholine analog on the activity of the angiotensin-converting enzyme in the lung, kidney and plasma of the arterial and renal venous blood of rats].
Angiotensin-converting enzyme (ACE) activity after i.v. carbachol administration increased in the renal cortex and decreased in the renal venous plasma. Carbachol did not affect the pulmonary ACE activity. The renal ACE pool seems to be more sensitive to cholinergic effect than the pulmonary one.
Fedorov
V I
VI
Institute of Laser Physics, Siberian Branch, Russian Acad. Sci., Novosibirsk, Russia.
Tkhaĭ
E K
EK
Cherkasova
O P
OP
D000109:Acetylcholine / Q000031:analogs & derivatives*; D000818:Animals; D001158:Arteries; D002217:Carbachol / Q000494:pharmacology*; D018678:Cholinergic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology*; D008168:Lung / Q000187:drug effects* / Q000201:enzymology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects*; D010949:Plasma / Q000187:drug effects* / Q000201:enzymology*; D051381:Rats; D014680:Veins
D018678:Cholinergic Agents; D002217:Carbachol; D007703:Peptidyl-Dipeptidase A; D000109:Acetylcholine
Vliianie analoga atsetilkholina na aktivnost' angiotenzinprevrashchaiushchego fermenta v legkom, pochke i plazme arterial'noĭ i pochechnoĭ venoznoĭ krovi u krys.