title: [Malignant mesothelioma of the pleura with etiological association to asbestos: report of 3 clinical cases].
abstract: Diffuse Malign Mesotheliomas (DMM) has a low background prevalence. High incidences of this tumor have been related to asbestos exposure in the past.
  
  
  OBJECTIVE
  To describe and discuss three clinical cases treated in our hospital, in which precise histopathologic diagnosis was made, and detailed occupational and environmental histories were taken, trying to identify in their past some kind of asbestos exposure.
  
  
  METHODS
  Three cases of DMM are described. Diagnosis was confirmed by histochemical analysis and electronmicroscopy. Detailed occupational and environmental histories were taken from subjects and their families, searching for past contact with asbestos.
  
  
  RESULTS
  The cases were diagnosed in a short period of time (two years), in a region of the country where many asbestos cement plants are located since the mid sixties. Skillful histological procedures were used. From these cases we found out that one had a twelve months period of exposure, 24 years before, in one of those plants. Another patient had an exposure for three years, as a bystander, in the same plant (also 24 years before) and a third patient was contaminated by asbestos brought home by his father in the 1950s (latency period of 30 years). All cases were histochemically studied and diagnosis confirmed by the presence of microvilli at electronmicroscopic examination.
  
  
  CONCLUSIONS
  These three cases seem to confirm the existence of the epidemiologic association with asbestos exposure in our country. Definition of diagnosis criteria, centralization of cases registry and the necessity of more attention to this kind of asbestos related disease are discussed and stressed, as many new cases like those described are thought to occur in the near future, as the latency period of the disease seems to match with that of industrial asbestos manipulation in Brazil.
authors.affiliation: Hospital de Clínicas, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), SP.
authors.forename: E M
authors.initials: EM
authors.lastname: de Capitani
authors.forename: K
authors.initials: K
authors.lastname: Metze
authors.forename: C
authors.initials: C
authors.lastname: Frazato Júnior
authors.forename: A M
authors.initials: AM
authors.lastname: Altemani
authors.forename: L
authors.initials: L
authors.lastname: Zambom
authors.forename: I F
authors.initials: IF
authors.lastname: Toro
authors.forename: E
authors.initials: E
authors.lastname: Bagatin
mesh_terms: D000328:Adult; D001194:Asbestos / Q000009:adverse effects*; D002273:Carcinogens / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000209:etiology*
chemical_list: D002273:Carcinogens; D001194:Asbestos
vernacular_title: Mesotelioma maligno de pleura com associação etiológica a asbesto: a propósito de três casos clínicos.