title: Development of pyothorax-associated pleural lymphoma in relation to focal cytokinemic condition and Epstein-Barr virus infection.
abstract: We report an initial case of pyothorax-associated pleural lymphoma (PAPL) in which the level of interleukin 6 (IL-6) was remarkably high in the pleural fluid contaminated with tumor cells; at the same time Epstein-Barr virus (EBV)-encoded small RNAs (EBERs) were detected in the lymphoma cells by in situ hybridization. These findings suggest the possibility that EBV-transformed B cells proliferated in the focal cytokinemic condition caused by long-standing chronic inflammation of the pleura and give us a clue to the lymphoma genesis of PAPL.
authors.affiliation: Department of Internal Medicine, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Danbara
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: Y
authors.initials: Y
authors.lastname: Fujino
authors.forename: I
authors.initials: I
authors.lastname: Okayasu
authors.forename: S
authors.initials: S
authors.lastname: Shionoya
mesh_terms: D000368:Aged; D002871:Chromosome Banding; D016207:Cytokines / Q000378:metabolism; D016724:Empyema, Pleural / Q000150:complications*; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D012367:RNA, Viral / Q000378:metabolism; D014412:Tumor Virus Infections / Q000150:complications*
chemical_list: D016207:Cytokines; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral