Inhibition of shear-induced platelet aggregation by Chinese herbal medicines.
Shear-induced platelet aggregation (SIPA) plays an important role in vascular diseases. In this study, SIPA was generated by a computerized cone-plate apparatus. Six compounds from Chinese herbal medicine were selected for in vitro and in vivo tests. Rabbit and rat were involved in the tests accordingly. Ligustrazine hydrochloridi appeared to be most effective for inhibition of SIPA. The inhibition rate of SIPA reached 44.2% (p < 0.01) for an in vitro concentration of 1 mg/ml, and 46.1% (p < 0.01) for an in vivo dose of 50 mg/kg.
Liao
F L
FL
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing.
Li
B
B
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical
D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin