title: The value of methylprednisolone in the treatment of an experimental sensorineural hearing loss following drill-induced ossicular chain injury: a randomized, blinded study in guinea-pigs.
abstract: In a previously established animal model a standardized drill-induced injury to the body of the incus was applied, and the effects on hearing were characterized by electrocochleography. In a placebo-controlled, randomized, blinded study methylprednisolone showed no protective effect in reducing or improving the auditory threshold shifts, which occurred within seconds after drilling and remained stable throughout the 5-week observation period. Therefore the otologic surgeon must pay close attention to avoiding any contact of a rotating burr with an ossicle in an intact ossicular chain.
authors.affiliation: Department of Otorhinolaryngology, University of Erlangen-Nuremberg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Gjuric
authors.forename: A
authors.initials: A
authors.lastname: Katalinic
authors.forename: W
authors.initials: W
authors.lastname: Buhr
authors.forename: S R
authors.initials: SR
authors.lastname: Wolf
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001300:Audiometry, Evoked Response; D001305:Auditory Fatigue / Q000187:drug effects; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology*; D007188:Incus / Q000187:drug effects / Q000293:injuries* / Q000503:physiopathology; D007274:Injections, Intraperitoneal; D007431:Intraoperative Complications / Q000503:physiopathology; D008775:Methylprednisolone / Q000494:pharmacology*; D013525:Surgical Instruments
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone