Age-related decrease of gamma-aminobutyric acid (GABA) release in brain of spontaneously hypertensive rats.
We studied the developmental alteration of GABA release in spontaneous ly hypertensive(SHR) and normotensive Wistar-Kyoto rat(WKY) brain. The release of [3H]GABA observed under high potassium(30 mM) in eleven-week-old(hypertensive) SHR hippocampus and the spontaneous release of [3H]GABA in the same aged SHR medulla oblongata were lower than those of age-matched WKY. We conclude that the GABAergic mechanisms may be different in SHR and WKY brain and may be associated with the development of hypertension.
Ichida
T
T
Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.
Takeda
K
K
Sasaki
S
S
Nakagawa
M
M
Hashimoto
T
T
Kuriyama
K
K
D017677:Age Distribution; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid