[Anti-dermaptophyte activity of phenolic compounds in "mokusaku-eki"].
"Mokusaku-eki," a kind of pyroligneous acid, is a dark brown color solution obtained from the charcoal burner of such Quercus spp. woods as a by-product. This is used as a folk medicine in water eczema. The n-hexane fraction of this solution contained several phenolic compounds such as 4-ethyl-2-methoxyphenol (3) and 2,6-dimethoxyphenol (4), which could not be found in the fresh woods. Among these compounds, 3 has the highest anti-dermaptophyte activity against Trichophyton mentagrophytes at minimum inhibitory concentration (MIC) 150 micrograms/ml.
Ikegami
F
F
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Sekine
T
T
Fujii
Y
Y
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D002606:Charcoal; D004352:Drug Resistance, Microbial; D008401:Gas Chromatography-Mass Spectrometry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011748:Pyrogallol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects*; D014934:Wood
D000470:Alkaloids; D010936:Plant Extracts; D011748:Pyrogallol; D002606:Charcoal; C058228:magnosprengerine; C010120:pyrogallol 1,3-dimethyl ether