Inhibitory effect of chlorpromazine on nematode eggs and larvae.
Chlorpromazine inhibited the hatching of eggs of the parasitic nematode Haemonchus contortus and the free-living nematode Caenorhabditis elegans. In both species, hatching occurred at a concentration of 100 microg/ml but was almost totally blocked at 400 microg/ml. In the case of C. elegans, the effect was shown to be reversible by removal of chlorpromazine after exposure of the eggs to the drug for 1 hr. Caenorhabditis elegans larvae that hatched in a chlorpromazine concentration of 100 microg/ml were killed, but those that hatched in a concentration of 6.25 microg/ml were not. Taken together with data published by others, these observations indicate that the first-stage larva of C. elegans is less sensitive to chlorpromazine than is the adult worm.
Patel
M R
MR
Department of Biology and Research Institute for Scientists Emeriti, Drew University, Madison, New Jersey 07940, USA.
Campbell
W C
WC
D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005243:Feces / Q000469:parasitology; D006189:Haemonchus / Q000187:drug effects*; D007814:Larva; D012756:Sheep; D015053:Zygote / Q000187:drug effects / Q000502:physiology
D018492:Dopamine Antagonists; D002746:Chlorpromazine