[Synthesis of triterpene 2,6-dideoxy-alpha-L-arabino-hexopyranosides from L-rhamnal. Their pharmacological properties].
Triterpene 2,6-dideoxy-alpha-L-arabino-hexopyranosides were synthesized by the glycosylation of oleanane triterpene alcohols with L-rhamnal acetate in the presence of cationite KU-2-8 and lithium bromide. 2,6-Dideoxy-alpha-L-arabino-hexopyranosides of allobetulin and methyl glycyrrhetinate showed pronounced antiulcerous activity; the latter also stimulated reparative skin regeneration in rats and was effective as a hepatoprotectant.
Baltina
L A
LA
Flekhter
O B
OB
Davydova
V A
VA
Ismagilova
A F
AF
Zarudiĭ
F S
FS
Nasyrov
Kh M
KhM
Gromakova
L S
LS
Tolstikov
G A
GA
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001965:Bromides; D002251:Carbon Tetrachloride; D006027:Glycosides / Q000138:chemical synthesis*; D007475:Ion Exchange Resins; D018020:Lithium Compounds; D008099:Liver / Q000187:drug effects; D051381:Rats; D012210:Rhamnose / Q000031:analogs & derivatives*; D012867:Skin / Q000187:drug effects; D014315:Triterpenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D001965:Bromides; D006027:Glycosides; D007475:Ion Exchange Resins; D018020:Lithium Compounds; D014315:Triterpenes; C040949:lithium bromide; D002251:Carbon Tetrachloride; D012210:Rhamnose
Sintez triterpenovykh 2,6-didezoksi-alpha-L-arabino-geksopiranozidov na osnove L-ramnalia i ikh farmakologicheskie svoĭstva.