title: Severe juvenile vaginal bleeding due to Glanzmann's thrombasthenia: case report and review of the literature.
abstract: Glanzmann's thrombasthenia is a rare inherited hematological disorder defined by deficiency or abnormality of the glycoprotein (GP) IIb-IIIa complex. Presenting symptoms are hemorrhagic events, mainly epistaxis, purpura, or menorrhagia. We describe the clinical course and management of a 14-year-old girl with Glanzmann's thrombasthenia and severe menorrhagia. Following treatment with 20 U of packed red blood cells, 37 U of platelets, 7 U of fresh frozen plasma, cryoprecipitate, intravenous estrogens, and methylergotrine maleate with no improvement, the uterine cavity was packed for 48 hr. This unusual procedure halted the bleeding and avoided the necessity for a hysterectomy. When treating acute menorrhagia in patients with Glanzmann's thrombasthenia, the physician should be familiar with the characteristics and all treatment modalities for this disorder.
authors.affiliation: Department of Obstetrics and Gynecology, Meir Hospital, Kfar Saba, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Markovitch
authors.forename: M
authors.initials: M
authors.lastname: Ellis
authors.forename: M
authors.initials: M
authors.lastname: Holzinger
authors.forename: S
authors.initials: S
authors.lastname: Goldberger
authors.forename: Y
authors.initials: Y
authors.lastname: Beyth
mesh_terms: D000293:Adolescent; D001792:Blood Platelets; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics; D013915:Thrombasthenia / Q000150:complications* / Q000235:genetics / Q000628:therapy
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex