title: [A patient with mixed collagen disease, antiphospholipid syndrome and Sjögren syndrome].
abstract: A 32-year-old female patient is described who suffered from common symptoms such as Raynaud's phenomenon and swollen fingers, high titers of antibodies to U1RNP, SLE-like findings, scleroderma-like findings and polymyositis-like findings. A diagnosis of mixed connective tissue disease (Sharp-syndrome) was established. In addition, the patient had antibodies against cardiolipin, thrombocytopenia, recurrent fetal loss and a history of deep venous thrombosis of her left leg which is typical for an antiphospholipid syndrome. The symptoms dry eyes and dry mouth pointed at secondary Sjögren's syndrome. The diagnosis of these disease entities and the therapeutic regimens are described and discussed.
authors.affiliation: Medizinische Klinik I, Universitätkliniken des Saarlandes.
authors.forename: M
authors.initials: M
authors.lastname: Zuber
authors.forename: N
authors.initials: N
authors.lastname: Kranzhöfer
authors.forename: R
authors.initials: R
authors.lastname: Lindemuth
authors.forename: F
authors.initials: F
authors.lastname: Hartmann
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D001241:Aspirin / Q000008:administration & dosage; D001379:Azathioprine / Q000008:administration & dosage; D001706:Biopsy; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis* / Q000188:drug therapy; D018482:Muscle, Skeletal / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D001379:Azathioprine; D001241:Aspirin; D011241:Prednisone
vernacular_title: Eine Patientin mit Mischkollagenose, Antiphospholipid-Syndrom und Sjögren-Syndrom.