An expression of anaplastic large cell lymphoma-associated antigens on HTLV-I-infected CD4+ T cells.
We investigated tumor-associated antigens induced by infection with human T-lymphotropic virus type I(HTLV-I). Anaplastic large cell lymphoma (APLL) antigens were found to be expressed on interleukin 2 (IL-2)-dependent, HTLV-I-infected CD4+ T-cell lines established from patients with adult T-cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis. However, APLL antigens were not detected on unstimulated lymphocytes, mitogen-activated T lymphocytes, or Epstein-Barr virus-infected B cells. Furthermore, APLL antigens were not found on IL-2-independent HTLV-I-transformed cells such as MT-I or MT-2. When naive CD4+ T cells were infected with HTLV-I in vitro in the presence of IL-2, the APLL antigens were detected on them 4 weeks after infection. The expression level increased in a time-dependent fashion. These results indicate that HTLV-I infection induces a unique category of tumor-associated antigens on CD4+ T cells.
Makino
M
M
Division of Human Retroviruses, Faculty of Medicine, Kagoshima University, Japan.
Yashiki
S
S
Fujiyoshi
T
T
Baba
M
M
Sonoda
S
S
D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D002461:Cell Line, Transformed; D002478:Cells, Cultured; D015490:HTLV-I Infections / Q000378:metabolism*; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D017730:Ki-1 Antigen / Q000378:metabolism*; D015458:Leukemia, T-Cell / Q000150:complications / Q000378:metabolism; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism / Q000821:virology; D015493:Paraparesis, Tropical Spastic / Q000150:complications / Q000378:metabolism*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013997:Time Factors
D007376:Interleukin-2; D017730:Ki-1 Antigen; D010835:Phytohemagglutinins; D015847:Interleukin-4