title: Removal of local field gradient artifacts in T2*-weighted images at high fields by gradient-echo slice excitation profile imaging.
abstract: Development of high magnetic field MRI techniques is hampered by the significant artifacts produced by B0 field inhomogeneities in the excited slices. A technique, gradient-echo slice excitation profile imaging (GESEPI), is presented for recovering the signal lost caused by intravoxel phase dispersion in T2*-weighted images. This technique superimposes an incremental gradient offset on the slice refocusing gradient to sample k-space over the full range of spatial frequencies of the excitation profile. A third Fourier transform of the initial two-dimensional image set generates an image set in which the artifacts produced by the low-order B0 inhomogeneity field gradients in the sample are separated and removed from the high-order microscopic field gradients responsible for T2* contrast. Application to high field brain imaging, at 3.0 T for human and at 9.4 T for immature rat imaging demonstrates the significant improvement in quality of the T2*-weighted contrast images.
authors.affiliation: Department of Radiology (Center for NMR Research), The Pennsylvania State University, College of Medicine, Hershey 17033, USA.
authors.forename: Q X
authors.initials: QX
authors.lastname: Yang
authors.forename: G D
authors.initials: GD
authors.lastname: Williams
authors.forename: R J
authors.initials: RJ
authors.lastname: Demeure
authors.forename: T J
authors.initials: TJ
authors.lastname: Mosher
authors.forename: M B
authors.initials: MB
authors.lastname: Smith
mesh_terms: D000465:Algorithms; D000818:Animals; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D019047:Phantoms, Imaging; D051381:Rats