title: Loss of serotonin-containing neurons in the raphe of patients with myotonic dystrophy: a quantitative immunohistochemical study and relation to hypersomnia.
abstract: Hypersomnia occurs frequently in patients with myotonic dystrophy (MyD). We performed a quantitative immunohistochemical study of serotonin (5-HT)-containing neurons linked to hypersomnia in the dorsal raphe nucleus (DRN) and the superior central nucleus (SCN) in 8 patients with MyD, 5 of whom showed hypersomnia, and in 12 age-matched controls. The densities of 5-HT neurons in the DRN and the SCN were significantly lower in MyD patients with hypersomnia than in MyD patients without hypersomnia and controls. These data suggest that the loss of 5-HT neurons of the DRN and the SCN is associated with the presence of hypersomnia in MyD.
authors.affiliation: Department of Neurology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ono
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Jinnai
authors.forename: F
authors.initials: F
authors.lastname: Kanda
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuoka
authors.forename: H
authors.initials: H
authors.lastname: Kurisaki
authors.forename: S
authors.initials: S
authors.lastname: Mitake
authors.forename: T
authors.initials: T
authors.lastname: Inagaki
authors.forename: T
authors.initials: T
authors.lastname: Yamano
authors.forename: K
authors.initials: K
authors.lastname: Nagao
mesh_terms: D000368:Aged; D006970:Disorders of Excessive Somnolence / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000150:complications* / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D011903:Raphe Nuclei / Q000473:pathology*; D012701:Serotonin / Q000032:analysis*
chemical_list: D012701:Serotonin