Neural noise limitations on infant visual sensitivity.
Visual contrast sensitivity is poor in newborn human infants, but improves rapidly to approach adult levels by 8 months of age. During this period, infant sensitivity can be limited by physical factors affecting photon capture, such as eye size and photoreceptor density. Here we show that infant visual sensitivity is also limited by high levels of noise in the neural transduction process. Using a non-invasive electrophysiological measurement and a visual noise titration technique, we have found that intrinsic neural noise in neonates is approximately nine times higher than in adults. As intrinsic neural noise decreases during infancy, contrast sensitivity improves proportionally, suggesting that neural noise places critical limits on contrast sensitivity throughout development. Moreover, contrast gain control, an inhibitory process that adjusts visual responses to changing stimulation, is in place and operating in infants as young as 6 weeks of age, in spite of high levels of neural noise and significant immaturities in contrast sensitivity. The contrast gain control that we observed in human neonates may serve as a building block for more complex forms of visual inhibition, which develop later in infancy.
Skoczenski
A M
AM
Smith-Kettlewell Eye Research Institute, San Francisco, California 94115, USA. sko@skivs.ski.org
Norcia
A M
AM
D000328:Adult; D000375:Aging / Q000502:physiology; D015350:Contrast Sensitivity / Q000502:physiology*; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology*; D012684:Sensory Thresholds