title: Group O human immunodeficiency virus-1 infections.
abstract: Human immunodeficiency viruses (HIV), the cause of AIDS, have remarkable genetic diversity. Among the HIV-1 viruses are the "major" (group M) HIV-1 subtypes and genetic "outliers" that have been designated as group O viruses. Group O viruses are most prevalent in parts of Africa, although they have also been reported in Europe and the United States and are associated with AIDS. Because group O viruses are so highly divergent, tests designed to detect group M viruses may be unreliable in the diagnosis of group O infection. Modification of these tests are needed to protect the safety of the blood supply.
authors.affiliation: Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: H W
authors.initials: HW
authors.lastname: Jaffe
authors.forename: G
authors.initials: G
authors.lastname: Schochetman
mesh_terms: D003140:Communicable Disease Control; D014644:Genetic Variation; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D010802:Phylogeny