Evaluation and management of pediatric solid ovarian tumors.
Solid ovarian tumors are uncommon in the pediatric population, but when they occur, they are a major source of anxiety for the patient and her family. The pediatric surgeon will be relied on to diagnose these tumors because they usually present as abdominal pain with a mass. The diagnostic evaluation consists of a carefully obtained history and physical examination, ultrasound examination, serum assay for tumor markers, and further radiographic evaluation as indicated. Two thirds of malignant tumors in children are germ cell tumors, and most of these are dysgerminomas or endodermal sinus tumors. A multimodal, team-oriented approach to therapy is crucial. Reproductive organ-sparing surgery with salpingo-oophorectomy, ascites sampling, nodule biopsy, omentectomy, and contralateral ovarian biopsy as indicated, may be curative for stage I tumors; more advanced or highly aggressive tumors should be treated with cytoreduction surgery and will require platinum-based chemotherapy. Postinduction surgery is indicated for progressive or recurrent disease. One third of tumors are physiologically active stromal tumors that often become apparent because of hormonal effects. Epithelial tumors, common in the adult, are uncommon in children and are of mild to moderate malignant potential. Other miscellaneous tumors and benign lesions are less common.
Lazar
E L
EL
Division of Pediatric Surgery, Babies and Childrens Hospital of New York, NY, USA.
Stolar
C J
CJ
D018236:Carcinoma, Embryonal / Q000175:diagnosis / Q000601:surgery; D002648:Child; D002822:Choriocarcinoma / Q000175:diagnosis; D003131:Combined Modality Therapy; D005260:Female; D018237:Germinoma / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D013724:Teratoma / Q000175:diagnosis / Q000601:surgery