title: Determination of coagulation inhibitor levels and resistance to activated protein C in patients undergoing gastric surgery for benign and malignant disorders.
abstract: The aim of the present study was to determine plasma levels of protein C antigen (PC:Ag) and activity (PC:Act), tissue factor pathway inhibitor (TFPI), protein S (PS), antithrombin (AT), heparin cofactor II (HCII), and resistance to activated protein C (APCR) before, during and after elective gastric surgery in order to compare patients with and without gastric malignancy. Blood was collected from a forearm vein of two age-matched patient groups undergoing elective gastric surgery, 9 patients with and 9 patients without gastric malignancy. The plasma levels of the parameters were determined preoperatively, intraoperatively, and on days 1 and 7 postoperatively. On the 1st and 7th postoperative day, plasma levels of HCII were significantly lower in patients operated for gastric malignancy than in those operated for benign disorders, but levels of TFPI, PC:Act, PC:Ag, AT, PS and APCR did not differ in the postoperative period. The day-to-day variation was also rather similar in the two patient groups.
authors.affiliation: Venous Thrombosis Group, Aalborg Hospital, Denmark.
authors.forename: B S
authors.initials: BS
authors.lastname: Andersen
authors.forename: H B
authors.initials: HB
authors.lastname: Rahr
authors.forename: J V
authors.initials: JV
authors.lastname: Sørensen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000991:Antithrombins / Q000032:analysis; D019774:Blood Coagulation Factor Inhibitors / Q000378:metabolism*; D002940:Circadian Rhythm; D004351:Drug Resistance; D005260:Female; D005743:Gastrectomy; D015844:Heparin Cofactor II / Q000032:analysis; D006801:Humans; D008074:Lipoproteins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000494:pharmacology*; D017293:Protein S / Q000032:analysis; D013272:Stomach Diseases / Q000378:metabolism / Q000601:surgery*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000601:surgery*; D013997:Time Factors
chemical_list: D000991:Antithrombins; D019774:Blood Coagulation Factor Inhibitors; D008074:Lipoproteins; D011486:Protein C; D017293:Protein S; C051928:lipoprotein-associated coagulation inhibitor; D015844:Heparin Cofactor II