title: Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes.
abstract: Fibrocalculous pancreatic diabetes (FCPD) is a type of diabetes secondary to tropical chronic non-alcoholic pancreatitis. Little is known about the aetiopathogenesis of FCPD. We studied glutamic acid decarboxylase antibodies (GAD-Ab) and islet cell antibodies (ICA) in patients with FCPD and compared the results with Type 1 (insulin dependent) diabetes mellitus, Type 2 (non-insulin-dependent) diabetes mellitus and non-diabetic subjects in Southern India. The prevalence of GAD-Ab was 7.0% (95% Confidence Interval (CI) 1.9-17.2) in FCPD, 47.5% (CI 31.4-64.0) in Type 1 (p < 0.001 compared to FCPD), 5.6% (CI 1.5-13.9) in Type 2 (non-significant (NS) compared to FCPD) and 0% in controls. The prevalence of ICA was 6.3% (CI 1.2-17.4) in FCPD, 53.8% (CI 37.1-70.0) in Type 1 (p < 0.001 compared to FCPD), 9.9% (CI 4.0-19.4) in Type 2 (NS compared to FCPD) and 4.7% (CI 0.4-16.1) in controls. The data suggest that in FCPD, the frequency of auto-antibodies is low and its aetiology is probably not linked to autoimmunity in the majority of the patients.
authors.affiliation: M.V. Diabetes Specialites Centre, and Madras Diabetes Research Foundation, Gopalapuram, Chennai, India.
authors.forename: V
authors.initials: V
authors.lastname: Mohan
authors.forename: R
authors.initials: R
authors.lastname: Deepa
authors.forename: E
authors.initials: E
authors.lastname: Bhatia
authors.forename: A K
authors.initials: AK
authors.lastname: Singh
authors.forename: G A
authors.initials: GA
authors.lastname: Hitman
authors.forename: P Z
authors.initials: PZ
authors.lastname: Zimmet
authors.forename: I R
authors.initials: IR
authors.lastname: MacKay
mesh_terms: D000328:Adult; D001324:Autoantigens / Q000032:analysis*; D002096:C-Peptide / Q000097:blood; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007194:India; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000276:immunology*; D010195:Pancreatitis / Q000150:complications*; D012016:Reference Values
chemical_list: D001324:Autoantigens; D002096:C-Peptide; D005968:Glutamate Decarboxylase