title: [Successful therapy of persistent androgen-induced cholestasis with ursodeoxycholic acid].
abstract: Drug-induced cholestasis can rarely persist for a considerable time period even after withdrawal of the drug. We report the case of a 55-year-old man with progressive jaundice after oral therapy with 17-alpha-methyltestosterone. Under empiric therapy with ursodeoxycholic acid the condition resolved completely. According to this observation, we suggest a therapeutic trial with ursodeoxycholic acid in cases of prolonged androgen-induced cholestasis.
authors.affiliation: Medizinische Poliklinik, Universität Würzburg.
authors.forename: H
authors.initials: H
authors.lastname: Mörk
authors.forename: O
authors.initials: O
authors.lastname: al-Taie
authors.forename: O
authors.initials: O
authors.lastname: Klinge
authors.forename: M
authors.initials: M
authors.lastname: Scheurlen
mesh_terms: D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008777:Methyltestosterone / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D045165:Testosterone Congeners / Q000008:administration & dosage / Q000009:adverse effects*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D002756:Cholagogues and Choleretics; D045165:Testosterone Congeners; D014580:Ursodeoxycholic Acid; D008777:Methyltestosterone
vernacular_title: Erfolgreiche Therapie einer persistierenden androgeninduzierten Cholestase mit Ursodesoxycholsäure.