Adrenoleukodystrophy--unusual CT and MR findings in two siblings. Case reports.
OBJECTIVE
To describe the unusual appearance of adrenoleukodystrophy (ALD) in MR imaging.


METHODS
An analysis was made of MR findings, histopathology and clinical course in the cases of two brothers with ALD.


RESULTS
The older brother presented with frontal contrast-enhanced lesions, including a cyst. These were initially misinterpreted as a tumour at both radiology and pathology. The correct diagnosis was made after the discovery of very-long-chain fatty acids in the blood. The younger brother presented initially with involvement of various segments of the corticospinal tract.


CONCLUSIONS
It is important that the radiologist be aware of the variants of ALD in MR imaging so as to avoid diagnostic mistakes.
Sundgren
P C
PC
Department of Diagnostic Radiology, University Hospital, Lund, Sweden.
Blennow
G
G
Englund
E
E
Holtås
S
S
D000326:Adrenoleukodystrophy / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D001706:Biopsy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis; D002648:Child; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009679:Nuclear Family; D014057:Tomography, X-Ray Computed