[Follow-up of patients with chronic aortic valve insufficiency with ACE inhibitor therapy].
Long-term treatment with ACE-inhibitors improves left ventricular function in patients with aortic regurgitation. But how does this advantage influence capacity? Using echocardiography and spiroergometry, we investigated 13 patients before and after a 3 month treatment with cilazapril (2.5-5 mg/d). Ventricular enddiastolic diameter-index decreased from 3.5 to 3.1 cm/m2 (p = 0.005), left ventricular endsystolic diameter-index from 2.3 to 2.0 cm/m2 (p = 0.005), and wallstress from 174 to 150 dyn/cm2 (p = 0.01). Left ventricular mass was reduced by 14% to 488 g (= 253 g/m2, p < 0.05). The regurgitant jet area decreased from 10.1 to 8.1 cm2 (p < 0.05). Wall thickness, workload, and maximal oxygen intake showed no significant difference during follow-up. These results indicate that left ventricular volumes and muscle mass in patients with aortic regurgitation are positively influenced by long term ACE-inhibition, which preserves exercise capacity.
Weyer
C
C
I. Medizinische Abteilung, DRK-Krankenhaus Neuwied.
Mohr-Kahaly
S
S
Erbel
R
R
Meyer
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002306:Cardiac Volume / Q000187:drug effects; D002908:Chronic Disease; D017315:Cilazapril / Q000009:adverse effects / Q000627:therapeutic use*; D004452:Echocardiography; D018618:Echocardiography, Doppler, Color; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013318:Stroke Volume / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D017315:Cilazapril
Verlaufsbeobachtung von Patienten mit chronischer Aortenklappeninsuffizienz unter ACE-Hemmer-Therapie.