title: The vestibular hair cells: post-transductional signal processing.
abstract: Hair cells in mechanosensory systems transduce mechanical stimuli into biological signals to be presented to and analyzed by the brain. Vestibular hair cells transduce stimuli primarily associated with the organism's orientation and motion in space. When examined superficially it may appear that the hair cells act as passive transducers whereby mechanical stimulation of their hair bundle results in transmitter release at their afferent synapses. In fact, hair cell functions are more complicated, and the mechanical signals are heavily processed even before being encoded in afferent nerve activity. Hair cells are different from one another in morphology, biophysics, transmitter and transmitter receptor complements, not only across different organs (as one might expect), but even in the same organ. This review focuses on hair cell morpho-physiological properties, ionic conductances, neurotransmitters/modulators and their receptors, second messengers and effectors. Special features of hair cell neurotransmission, as the synaptic body and the presence of autoreceptors and local circuits, are also discussed, as is the possibility of a differential modulation of hair cell transmitter release in the resting and mechanically-stimulated states.
authors.affiliation: Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Guth
authors.forename: P
authors.initials: P
authors.lastname: Perin
authors.forename: C H
authors.initials: CH
authors.lastname: Norris
authors.forename: P
authors.initials: P
authors.lastname: Valli
mesh_terms: D000818:Animals; D018069:Hair Cells, Vestibular / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*