Arterial ketone body ratio does not correlate with ischemic changes during major hepatectomy.
OBJECTIVE
The arterial ketone body ratio (AKBR) has been proposed as an accurate indicator of hepatic mitochondrial redox potential. However, recent studies of the utility of the AKBR as a biochemical marker have been called into question. It is not clear whether the AKBR is closely related to ischemic changes during major hepatectomy.


METHODS
Arterial acetoacetate and beta-hydroxybutyrate concentrations were measured in eleven patients who underwent major hepatectomy. The ratio between them (AKBR) was calculated before and after vascular occlusion during the hepatectomy procedure.


RESULTS
The AKBR increased following normothermic arterial or portal venous ischemia as compared to the levels prior to vascular occlusion in 36.4% of the patients who underwent major hepatectomy. An AKBR of less than 0.5 prior to vascular occlusion did not correlate with preoperative hepatocellular function. An AKBR of less than 0.7 throughout surgery was not a consistent risk factor for postoperative complications or liver dysfunction.


CONCLUSIONS
The AKBR does not correlate with ischemic changes or postoperative complications after major hepatectomy.
Hanazaki
K
K
Department of Surgery, Nagano Red Cross Hospital, Japan.
Wakabayashi
M
M
Sodeyama
H
H
Makiuchi
A
A
Igarashi
J
J
Yokoyama
S
S
Sode
Y
Y
Kawamura
N
N
Miyazaki
T
T
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000097:blood; D000328:Adult; D000368:Aged; D005260:Female; D006498:Hepatectomy; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007511:Ischemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D007657:Ketone Bodies / Q000097:blood*; D008099:Liver / Q000098:blood supply*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000378:metabolism; D010084:Oxidation-Reduction
D000090:Acetoacetates; D006885:Hydroxybutyrates; D007657:Ketone Bodies; C016635:acetoacetic acid; D020155:3-Hydroxybutyric Acid