Eight-epi-PGF2alpha: a possible marker of lipid peroxidation in term infants with severe pulmonary disease.
A prostaglandin F2-like compound, 8-epi-PGF2alpha, formed from oxidation of arachidonate, has been proposed as an indicator of lipid peroxidation. We determined whether tracheal aspirate or urinary 8-epi-PGF2alpha levels would differ over time or between infants in a control group and infants with severe respiratory failure. We correlated tracheal aspirate 8-epi-PGF2alpha levels with the fraction of inspired oxygen and with mean airway pressures at 24 and 48 hours of life. Levels in tracheal aspirates were in the range of 0 to 36 pg/microg of fSC of IgA and were higher in infants with severe pulmonary disorders compared with those in infants in the control group (p < 0.02). Urinary concentrations did not discriminate between sick infants and infants in the control group.
Goil
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S
The Children's Mercy Hospital, Department of Pediatrics, The University of Missouri-Kansas City School of Medicine, 64108-9898, USA.
Truog
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WE
Barnes
C
C
Norberg
M
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Rezaiekhaligh
M
M
Thibeault
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D
D015415:Biomarkers / Q000032:analysis; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000032:analysis / Q000652:urine; D005122:Exudates and Transudates / Q000737:chemistry; D028441:F2-Isoprostanes; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D015227:Lipid Peroxidation; D008171:Lung Diseases / Q000503:physiopathology*; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology* / Q000652:urine; D014132:Trachea
D015415:Biomarkers; D028441:F2-Isoprostanes; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost