title: Hemodilution and hyperoxia locally change distribution of regional pulmonary perfusion in dogs.
abstract: In seven anesthetized dogs, the effects of acute normovolemic hemodilution (ANH) to a hematocrit of 20 and 8% and the effects of hyperoxic ventilation (100% oxygen) on distribution of regional pulmonary blood flow (rPBF; radioactive microspheres) were investigated. Normovolemia was monitored with blood volume measurements (indocyanine green dilution kinetics). Before ANH, fractal dimension (D) of rPBF in the whole lung was 1.19 +/- 0.09 (mean +/- SD). Spatial correlation (rho) of rPBF in the whole lung was 0.6 +/- 0.08. D is a resolution-independent measure for global rPBF distribution, and rho is the averaged flow relationship of directly neighboring lung samples. With regard to the entire lung, neither ANH nor hyperoxia changed D or rho. With regard to horizontal, isogravitational planes, ANH induced opposite changes of rPBF heterogeneity depending on the vertical location of the plane and the parameter used. In ventral planes, a change in relative dispersion (SD/mean) indicated decreased homogeneity. However, rho suggested more homogeneous perfusion. Hyperoxia restored baseline rPBF distribution. Our data suggest that ANH causes different alterations of heterogeneity of rPBF depending on location within the lung.
authors.affiliation: Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Kleen
authors.forename: O
authors.initials: O
authors.lastname: Habler
authors.forename: J
authors.initials: J
authors.lastname: Hutter
authors.forename: G
authors.initials: G
authors.lastname: Kemming
authors.forename: A
authors.initials: A
authors.lastname: Podtschaske
authors.forename: M
authors.initials: M
authors.lastname: Tiede
authors.forename: M
authors.initials: M
authors.lastname: Welte
authors.forename: P E
authors.initials: PE
authors.lastname: Keipert
authors.forename: S
authors.initials: S
authors.lastname: Batra
authors.forename: N S
authors.initials: NS
authors.lastname: Faithfull
authors.forename: C
authors.initials: C
authors.lastname: Corso
authors.forename: B
authors.initials: B
authors.lastname: Zwissler
authors.forename: K
authors.initials: K
authors.lastname: Messmer
mesh_terms: D000818:Animals; D001810:Blood Volume; D004285:Dogs; D004395:Dye Dilution Technique; D005260:Female; D006400:Hematocrit; D006438:Hemodilution; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D007208:Indocyanine Green; D007700:Kinetics; D008297:Male; D008863:Microspheres; D010100:Oxygen / Q000008:administration & dosage; D011652:Pulmonary Circulation; D012039:Regional Blood Flow
chemical_list: D007208:Indocyanine Green; D010100:Oxygen