title: Primary malignancies of the nasal fossa and paranasal sinuses: comparison between UICC classification and a new staging system.
abstract: There is not a general accepted classification for tumor of nasal cavity and paranasal sinuses, and furthermore, there is a lack in the most commonly used T staging, the Union Internationale Contre Cancer (UICC) and the American Joint Committee on Cancer systems, which offer a classification strictly for tumors of the maxillary antrum. A new T staging (NTS) has been proposed: It is applicable to neoplasms arising from the mucosa of nasal fossa and all paranasal sinuses. To evaluate the advantages of NTS, a retrospective analysis of 54 cases of paranasal sinus cancers in patients admitted between 1983 and 1993 was undertaken. Tumors were staged according to UICC and to NTS systems, and then a statistical comparison was performed. Univariate analysis stratified according with T stage, tumors origin, and treatment modalities demonstrated different survival rates in both systems. Multivariate analysis showed a higher risk of death into the T4 category coded according with NTS with respect to UICC system. We concluded that NTS offers some advantages: (1) It presents a general view of the maxillofacial cavities; (2) it prognosticates successfully for T stage (1-4); (3) it gives significant improvement in detecting the risk of death for T4 when compared with the UICC system.
authors.affiliation: Department of Maxillo-Facial Surgery, University of Ferrara, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Carinci
authors.forename: A
authors.initials: A
authors.lastname: Farina
authors.forename: E
authors.initials: E
authors.lastname: Padula
authors.forename: C
authors.initials: C
authors.lastname: Calearo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000145:classification* / Q000401:mortality / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000145:classification* / Q000401:mortality / Q000473:pathology*; D012044:Regression Analysis; D016019:Survival Analysis