title: Photodynamic therapy in the management of metastatic cutaneous adenocarcinomas: case reports from phase 1/2 studies using tin ethyl etiopurpurin (SnET2).
abstract: OBJECTIVE
  Photodynamic therapy (PDT) using a photoreactive purpurin, tin ethyl etiopurpurin (SnET2, Purlytin, Miravant Medical Technologies, Santa Barbara, CA), was investigated as a treatment for cutaneous metastatic disease that had failed other treatment options.
  
  
  METHODS
  Three patients with biopsy-proven metastatic adenocarcinoma of the skin were treated with a single dose of the study drug. Twenty-four hours later, the patients were exposed to a laser light at 664 nm in multiple light fields. Patients were followed for 6 months for safety, efficacy, recurrence, and palliative response.
  
  
  RESULTS
  After PDT with SnET2, complete response was observed in all 13 treated lesions in three patients, with no evidence of recurrence at any treated site at the 6-month follow-up. Two patients subsequently died of distant metastatic disease. One patient with local chest wall recurrence after mastectomy was disease-free 24 months after PDT.
  
  
  CONCLUSIONS
  PDT with SnET2 could be an effective treatment in locally advanced metastatic carcinoma of the skin.
authors.affiliation: Department of Surgery, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kaplan
authors.forename: R G
authors.initials: RG
authors.lastname: Somers
authors.forename: R H
authors.initials: RH
authors.lastname: Greenberg
authors.forename: J
authors.initials: J
authors.lastname: Ackler
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010778:Photochemotherapy; D011166:Porphyrins / Q000627:therapeutic use; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D013365:Submandibular Gland Neoplasms / Q000473:pathology
chemical_list: D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C063166:tin etiopurpurin