Thermoregulation in the canine prostate during transurethral microwave hyperthermia, Part II: Blood flow response.
Recent studies on transurethral-applied local hyperthermia in both the canine and human prostate have revealed significant effects of natural thermoregulation on the therapeutical results in the prostate. Using a thermal clearance method, blood perfusion rates were measured within different regions in the canine prostate under normal and hyperthermic conditions. It has been found that the canine-prostatic blood perfusion is strongly linked to the geometrical location within the gland, the local tissue temperature, and the imposed thermal dosage. Results from this research are expected to provide a better understanding of the thermoregulatory behaviour in the canine prostate, and thus lay an important foundation for predicting tissue temperature in the human prostate during transurethral microwave hyperthermia.
Xu
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LX
Department of Applied Sciences, College of Staten Island, City University of New York, USA.
Zhu
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L
Holmes
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KR
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D004285:Dogs; D005334:Fever; D008297:Male; D008872:Microwaves / Q000627:therapeutic use; D010477:Perfusion; D011467:Prostate / Q000098:blood supply / Q000166:cytology / Q000528:radiation effects*; D012039:Regional Blood Flow / Q000502:physiology / Q000528:radiation effects; D013696:Temperature; D014521:Urethra / Q000528:radiation effects