[Protective effect of colchicine on tissue damage caused by free radicals in hepatic cirrhosis: an experimental study in rats].
The present study was undertaken to evaluate the effect of colchicine on oxidative stress in cirrhosis assessed by lipid peroxidation products. Wistar rats were used and induced hepatic cirrhosis by carbon tetrachloride. After the cirrhosis-induced period colchicine was administrated daily during 90 days. Lipid peroxidation was evaluated by the thiobarbituric acid reactive substances method (TBARS) and chemiluminescence initiated by tert-butyl hydroperoxide. The liver was submitted to histological evaluation to check whether cirrhosis was present. The results demonstrated an higher increase in lipid peroxide levels in cirrhotic tissue when compared with normal tissue and it was decreased by colchicine treatment (P < 0.05). Observing this study, we can conclude that hepatic cirrhosis produce an higher oxidative stress than normal liver and it can be decreased by colchicine treatment.
Rhoden
E L
EL
Departamento de Farmacologia e Toxicologia da Fundação Federal Faculdade de Ciências Médicas de Porto Alegre (FFFCMPA).
Mauri
M
M
Petteffi
L
L
Belló-Klein
A
A
Zettler
C G
CG
Rhoden
C R
CR
D000818:Animals; D003078:Colchicine / Q000494:pharmacology*; D005609:Free Radicals; D015227:Lipid Peroxidation; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000378:metabolism / Q000503:physiopathology*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D005609:Free Radicals; D003078:Colchicine
Efeito protetor da colchicina no dano tecidual causado por radicais livres na cirrose hepática: um estudo experimental em ratos.