[The relationship between anticonvulsant and anti-anxiety effects of calcium channel blockers].
The effect of calcium channel blockers on the development of convulsive and anxiogenic actions of corasole and caffeine was studied on mice. Verapamil, nifedipine, cinnarizine, and fendilin attenuated corasole-induced convulsions were attenuated by convulsions. Nifedipine also weakened while fendilin increased the course of convulsions induced by caffeine. All calcium antagonists did not change the effects of corasole and caffeine in the dark-light chamber test and the test in an elevated plus maze (anxiogens shortened the time that the mice stayed in the open sections of the maze). It is concluded that there are no relations between the anticonvulsive and anxiolytic effects of calcium antagonists.
Kozlovskiĭ
V L
VL
Department of Clinical and Experimental Psychopharmacology, Bechterev Psychoneurological Institute, St. Petersburg, Russia.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002110:Caffeine / Q000633:toxicity; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000633:toxicity; D002936:Cinnarizine / Q000494:pharmacology; D003292:Convulsants / Q000633:toxicity; D004110:Diltiazem / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D005275:Fendiline / Q000494:pharmacology; D008297:Male; D051379:Mice; D009543:Nifedipine / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D014700:Verapamil / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D000697:Central Nervous System Stimulants; D003292:Convulsants; D002936:Cinnarizine; D002110:Caffeine; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine; D005275:Fendiline; D010433:Pentylenetetrazole
O sviazi mezhdu protivosudorozhnym i anksioliticheskim deĭstviem blokatorov kal'tsievykh kanalov.