The response of adenoid cystic carcinoma to tamoxifen.
Adenoid cystic carcinoma of the parotid gland often recurs locally, or metastases develop, after initial treatment with surgery and radiotherapy. We report a patient with an inoperable local recurrence of previously irradiated adenoid cystic carcinoma, who was treated with tamoxifen, an oestrogen receptor antagonist. After 18 months of treatment with tamoxifen, MRI showed a partial response, and further clinical progression of the disease was halted.
Shadaba
A
A
Royal National Throat, Nose and Ear Hospital, London, UK.
Gaze
M N
MN
Grant
H R
HR
D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D003528:Carcinoma, Adenoid Cystic / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010166:Palliative Care; D010307:Parotid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013629:Tamoxifen / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D013629:Tamoxifen