Bone fracture history and prospective bone fracture risk of hemodialysis patients are related to apolipoprotein E genotype.
This investigation of 219 hemodialysis patients relates the history and prospective risk of bone fractures to apolipoprotein E (apoE) genotype. A greater percentage of the 41 patients with the E3/4 and E4/4 genotypes than of the 38 patients with the E2/3 and E2/2 genotypes had a history of bone fractures at the time of recruitment (44% versus 16%, P < 0.005). During the 4 years following recruitment, more of the patients with apoE genotypes E3/4 and E4/4 than with apoE genotypes E2/3 and E2/2 suffered bone fractures, but this difference was not statistically significant (17.1 versus 5.3%, P < 0.1). ApoE genotype appears to be an important genetic risk factor for bone fracture, possibly due to its previously reported influence on vitamin K concentrations in blood.
Kohlmeier
M
M
Department of Nutrition, CB #7400 School of Public Health, University of North Carolina, Chapel Hill 27599-7400, USA.
Saupe
J
J
Schaefer
K
K
Asmus
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D001842:Bone and Bones / Q000293:injuries*; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D012307:Risk Factors; D014812:Vitamin K / Q000235:genetics / Q000378:metabolism
D001057:Apolipoproteins E; D014812:Vitamin K