Corticosteroid therapy does not alter the threshold for contraction-induced injury in dystrophic (mdx) mouse diaphragm.
The effects of methylprednisolone therapy on the susceptibility of dystrophin-deficient myofibers to contraction-induced injury were evaluated in the mdx mouse diaphragm model of Duchenne dystrophy. Mdx myofibers were abnormally vulnerable to injury induced by high-stress eccentric contractions. However, methylprednisolone therapy did not significantly alter the degree of contraction-induced injury. These data suggest that beneficial effects of corticosteroid therapy in Duchenne dystrophy are unlikely to be related to a change in the threshold for contraction-induced myofiber damage.
Yang
L
L
Respiratory Division, Royal Victoria Hospital, Montreal, Quebec, Canada.
Luo
J
J
Petrof
B J
BJ
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D003964:Diaphragm; D008775:Methylprednisolone / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D018101:Mice, Inbred mdx; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D009137:Muscular Dystrophy, Animal / Q000188:drug therapy* / Q000503:physiopathology*
D000305:Adrenal Cortex Hormones; D008775:Methylprednisolone