title: Expression of progesterone receptor form A and B mRNAs in uterine leiomyoma.
abstract: This study was designed to determine the expression pattern of progesterone receptor form A (PR-A) and B (PR-B) mRNAs in uterine leiomyoma. Approximately equal expression of PR-A and PR-B mRNAs was designated as type AB and dominant expression of PR-B mRNA as type B. In all cases of normal uterine myometrium, PR mRNA expression was type AB. Alteration to type B in the superficial part of uterine leiomyoma was observed in approximately 40% of cases. Therefore, the relative overexpression of PR-B mRNA in the surface of uterine leiomyoma might reveal an activated phenotype of progestational proliferation, plausibly related to the growth of uterine leiomyoma.
authors.affiliation: Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Fujimoto
authors.forename: R
authors.initials: R
authors.lastname: Hirose
authors.forename: S
authors.initials: S
authors.lastname: Ichigo
authors.forename: H
authors.initials: H
authors.lastname: Sakaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Tamaya
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis*; D014158:Transcription, Genetic; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery
chemical_list: D012333:RNA, Messenger; D011980:Receptors, Progesterone; C101118:progesterone receptor A; C097314:progesterone receptor B