Comparative effect of gentamicin and pefloxacin treatment on the late stages of mouse typhoid.
The present study compares the ability of gentamicin and pefloxacin to eradicate a Salmonella infection in BALB/c mice when the treatment is instituted in the late stages of the infection. The results indicate that pefloxacin is highly effective in the treatment of mouse typhoid even when the therapy is instituted after the suppression of bacterial growth in the reticuloendothelial system (RES). Conversely, gentamicin treatment only reduced the bacterial load in the RES of infected mice, but neither induced the clearance of the organisms from the RES, nor prevented the resurgence of bacterial growth. Even when using gentamicin at a high dosage, bacterial clearance could not be accomplished.
Bonina
L
L
Istituto di Microbiologia, Università di Messina, Italy.
Costa
G B
GB
Mastroeni
P
P
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004334:Drug Administration Schedule; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D007111:Immunity, Cellular; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012157:Mononuclear Phagocyte System / Q000382:microbiology; D015366:Pefloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D012481:Salmonella Infections, Animal / Q000188:drug therapy*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000254:growth & development; D013154:Spleen / Q000382:microbiology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005839:Gentamicins; D015366:Pefloxacin