title: Splenectomy for HIV-related immune thrombocytopenia: comparison with results of splenectomy for non-HIV immune thrombocytopenic purpura.
abstract: OBJECTIVE
  To determine the effectiveness and safety of splenectomy for patients with human immunodeficiency virus (HIV)-related immune thrombocytopenia, using the results of splenectomy for patients with non-HIV immune thrombocytopenic purpura as a control group for comparison.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Tertiary care university hospital.
  
  
  METHODS
  Fourteen patients who underwent splenectomy for symptomatic, medically refractory HIV-related immune thrombocytopenia at this hospital from 1988 to 1997. During the same period, 20 patients had splenectomy for treatment of non-HIV immune thrombocytopenic purpura.
  
  
  METHODS
  Splenectomy.
  
  
  METHODS
  Platelet response, need for postsplenectomy medical therapy, progression of HIV disease, and complications.
  
  
  RESULTS
  All patients with HIV-related thrombocytopenia had a complete early platelet response to splenectomy, with an elevation of the platelet count to greater than 100X10(9)/L. After a median follow-up of 26.5 months, all but 1 patient had a sustained complete remission with no need for medical therapy for thrombocytopenia. Splenectomy was more effective in the HIV-related thrombocytopenia group than in the non-HIV immune thrombocytopenic purpura group, with significantly higher platelet counts at 1 week and 1 month after splenectomy in the HIV group (t test, P=.02 and P=.009, respectively). There were significantly fewer patients needing medical therapy for thrombocytopenia after splenectomy in the HIV group (chi2 test, P=.02). There were no remarkable short- or long-term complications in the patients with HIV infection, including no overwhelming postsplenectomy infections. Three patients have died, and 2 patients have developed AIDS since operation.
  
  
  CONCLUSIONS
  Splenectomy is effective treatment for patients with symptomatic HIV-related thrombocytopenia that is resistant to medical therapy. The effectiveness of this treatment suggests that the predominant mechanism of thrombocytopenia in HIV-infected patients is increased destruction of platelets because of platelet-associated immunoproteins.
authors.affiliation: Department of Surgery, St Vincent's Hospital, Sydney, New South Wales, Australia.
authors.forename: R V
authors.initials: RV
authors.lastname: Lord
authors.forename: M J
authors.initials: MJ
authors.lastname: Coleman
authors.forename: S T
authors.initials: ST
authors.lastname: Milliken
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000601:surgery; D012189:Retrospective Studies; D013156:Splenectomy; D013921:Thrombocytopenia / Q000276:immunology* / Q000601:surgery* / Q000821:virology; D016896:Treatment Outcome