The apolipoprotein CI A allele as a risk factor for Alzheimer's disease.
The E4 allele for the apolipoprotein E gene has been shown to be a significant risk factor for Alzheimer's disease. The gene is located in a conserved gene cluster on chromosome 19q12-13.2. Downstream from APOE is the gene for apolipoprotein CI. We had previously shown that the presence of a restriction site in the 5'end of APOCI (the A allele) was present at increased frequency in Alzheimer's patients and could also be considered as a risk factor for the disease. We have extended these studies and find that both familial and sporadic cases of Alzheimer's disease have a higher frequency of the APOCI A allele than control spouses. In addition, male patients with the APOCI A allele and/or the APOE4 allele tend to have an earlier age of onset of the disease than female patients.
Poduslo
S E
SE
Department of Neurology, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
Neal
M
M
Herring
K
K
Shelly
J
J
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053302:Apolipoprotein C-I; D053327:Apolipoprotein E4; D001056:Apolipoproteins C / Q000235:genetics*; D001057:Apolipoproteins E; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012737:Sex Factors
D053302:Apolipoprotein C-I; D053327:Apolipoprotein E4; D001056:Apolipoproteins C; D001057:Apolipoproteins E; C024406:endodeoxyribonuclease HpaI; D015252:Deoxyribonucleases, Type II Site-Specific