title: A murine TSPY.
abstract: Sequences homologous to human and bovine TSPY were isolated from M. musculus testicular cDNA, and a nearly full-length gene was polymerase chain reaction (PCR) amplified from mouse genomic DNA. This gene is apparently non-functional. Contrary to the situation encountered in species along the primate and artiodactyl lineages, in which TSPY is moderately repetitive, murine Tspy appears to be single copy. Murine Tspy is located on Yp, i.e. in the same syntenic group as in man. Sequence comparisons of murine, human and bovine TSPY exons suggest that TSPY became non-functional during rodent evolution.
authors.affiliation: Institute of Human Genetics, Medizinische Hochschule Hannover, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Vogel
authors.forename: H
authors.initials: H
authors.lastname: Boettger-Tong
authors.forename: I
authors.initials: I
authors.lastname: Nanda
authors.forename: F
authors.initials: F
authors.lastname: Dechend
authors.forename: A I
authors.initials: AI
authors.lastname: Agulnik
authors.forename: C E
authors.initials: CE
authors.lastname: Bishop
authors.forename: M
authors.initials: M
authors.lastname: Schmid
authors.forename: J
authors.initials: J
authors.lastname: Schmidtke
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D005091:Exons / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D008297:Male; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D016366:Open Reading Frames / Q000235:genetics; D011544:Pseudogenes / Q000235:genetics*; D012326:RNA Splicing; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D051876:Sex-Determining Region Y Protein; D013737:Testis; D014157:Transcription Factors; D014998:Y Chromosome / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors