[Variation of amino acids in relation to age in Down syndrome subjects].
BACKGROUND
A preliminary study of plasma and urinary amino acid concentration in Down's syndrome subjects had shown some impairments.


METHODS
A comparative study of the variations of amino acid concentration with age in Down's syndrome subjects aged 0 to 60 years and in control subjects aged 0 to 94 years was made in order to determine whether these impairments could be explained by generalized premature aging, or by a specific gene dosage effect.


RESULTS
Two major changes (P < 0.001) were found in Down's syndrome: a decrease in plasma concentration of serine at any age, which could be due to a dosage effect of cytathionine-beta-synthase, and an increase in plasma lysine concentration in patients above 10 year's old, probably due to premature aging. Other minor changes were also present in plasma and urine, also possibly explained by premature aging.


CONCLUSIONS
Other studies are necessary to evaluate possible consequences of such changes in the amino acid profiles.
Mircher
C
C
Laboratoire de neuroendocrinologie, faculté de pharmacie, Paris, France.
Salabelle
A
A
Peeters
M A
MA
Rabier
D
D
Parvy
P
P
Kamoun
P
P
Lejeune
J
J
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000596:Amino Acids / Q000097:blood* / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D007223:Infant; D008239:Lysine / Q000097:blood; D008297:Male; D008875:Middle Aged; D012694:Serine / Q000097:blood
D000596:Amino Acids; D012694:Serine; D008239:Lysine
Variation des acides aminés en fonction de l'âge chez des sujets trisomiques 21.