Soluble CD30, dehydroepiandrosterone sulfate and dehydroepiandrosterone in atopic and non atopic children.
Elevated levels of soluble CD30-sCD30 (possibly related to Th2) are seen in atopy and other diseases. Dehydroepiandrosterone (DHEA) may regulate Th1/Th2 balance. The aim was to study the relationship between the levels of sCD30, DHEAS and DHEA in atopic (A) and non atopic (B) children, to assess immune-endocrine interactions. We studied 36 children (8-15 years), 18 (A) monosensitised to Dermatophagoides Pteronyssinus (Dpt.), and 18 (B) with isolate rhinitis (R) or asthma (BA) and R (33.3%) without differences in age and sex. They were all HIV negative and free from any medication. It was determined sCD30, DHEAS and DHEA. There was no statistically significant differences between A and B for the levels of DHEAS, DHEA suggesting that the role of this regulation in Th2 type is not important in patients with allergic disease in this age group. sCD30: A-mean 121.1U/ml; B-mean 53.9U/ml. This difference is statistically significant-p = 0.02. sCD30 in patients only with R showed also significant differences-p = 0.01. These results could reflect the Th2 profile. There is an overlap of the values (for R < 80 U/ml; for BA + R < 140 U/ml). Due to this only values > 80 U/ml for R and > 140 U/ml for BA + R could be considered discriminating for atopy.
Nogueira
J M
JM
Serviço de Immunoalergologia, Hospital de Dona Estefânia, Lisboa, Portugal.
Pinto
P L
PL
Loureiro
V
V
Prates
S
S
Gaspar
A
A
Almeida
M M
MM
Pinto
J E
JE
D000293:Adolescent; D000818:Animals; D001249:Asthma / Q000097:blood; D002648:Child; D003687:Dehydroepiandrosterone / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood*; D017730:Ki-1 Antigen / Q000097:blood*; D008297:Male; D008925:Mites / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000097:blood; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood; D012995:Solubility; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D017730:Ki-1 Antigen; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate