title: Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania.
abstract: Leishmania exploits several strategies to survive within the phagolysosome of vertebrate macrophages and be transmitted by sand fly vectors. Recent advances in functional genetic analysis provide a new avenue for identifying genes implicated in the infectious cycle of the parasite, such as those necessary for the synthesis and expression of the key surface glycoconjugate, lipophosphoglycan (LPG).
authors.affiliation: Dept of Molecular Microbiology, Washington University Medical School, St Louis, MO 63110, USA. beverley@borcim.wustl.edu
authors.forename: S M
authors.initials: SM
authors.lastname: Beverley
authors.forename: S J
authors.initials: SJ
authors.lastname: Turco
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D017125:Genes, Protozoan; D006028:Glycosphingolipids / Q000032:analysis / Q000235:genetics*; D007891:Leishmania / Q000737:chemistry / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity*; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013329:Structure-Activity Relationship; D014774:Virulence / Q000235:genetics*
chemical_list: D006028:Glycosphingolipids; C008290:lipophosphonoglycan