The pathogenesis of atherosclerosis.
The hypothesis that atherosclerosis is a 'response to injury' is now generally accepted. This paper briefly reviews factors that can damage the vascular endothelium plus the formation of fatty streak lesions, thrombogenic surfaces, fibrous plaques and complex advanced lesions of atherosclerosis.
Schachter
M
M
Department of Clinical Pharmacology, Imperial College School of Medicine at St. Mary's, London, UK. M.Schachter@ic.ac.uk
D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D002450:Cell Communication; D002455:Cell Division; D002463:Cell Membrane Permeability; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D014661:Vasoconstriction
D016326:Extracellular Matrix Proteins; D006133:Growth Substances; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein