title: Effect of magnesium sulfate administration on subendocardial and subepicardial perfusion.
abstract: The objective of this study was to determine the effect of systemic MgSO4 infusion on subendocardial and subepicardial perfusion. Seventeen spontaneously breathing piglets were examined. Myocardial perfusion was measured using radiolabeled microspheres at baseline, 30 and 60 min after either MgSO4 (80 mg/kg) or saline infusion. Blood pressure, heart rate, and cardiac output were also measured at these time intervals. Comparison of the magnesium-induced changes in systemic blood pressure and on subendocardial and subepicardial perfusion at 30 and 60 min with values obtained with saline solution at 30 and 60 min, yielded no statistically significant difference (Tables 1-3). The ratio of subendocardial/subepicardial blood flow and subendocardial and subepicardial coronary vascular resistance at 30 and 60 min revealed no statistically significant differences between the magnesium and the control group (Table 3). There were no statistically significant difference in cardiac output and heart rate during any of the measured periods (Table 2). Our results suggest that the administration of MgSO4 does not alter the ratio of subendocardial/subepicardial blood flow and the ratio of subendocardial/subepicardial coronary vascular resistance.
authors.affiliation: The Research Unit-Experimental Surgery, Hospital La Paz, Facultad de Medicina, Universidad Autonoma, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Fantidis
authors.forename: T A
authors.initials: TA
authors.lastname: Stiris
authors.forename: D
authors.initials: D
authors.lastname: Blanco
authors.forename: R M
authors.initials: RM
authors.lastname: Jarabo
authors.forename: M J
authors.initials: MJ
authors.lastname: Del Cerro
authors.forename: M A
authors.initials: MA
authors.lastname: Ruiz
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D006321:Heart / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008863:Microspheres; D011877:Radionuclide Imaging; D012462:Saline Solution, Hypertonic; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D012462:Saline Solution, Hypertonic; D008278:Magnesium Sulfate