[The effect of a stable acetylcholine analog on angiotensin-converting enzyme activity in the lung, kidney and arterial blood plasma of rats with increased sympathetic activity].
Anesthetised rats with sympathetic overactivity were selected by previous testing on the base of the plasma level of corticosterone, norepinephrine and epinephrine, arterial pressure reactivity on epinephrine and acetylcholine injections, and difference between carotid and tail arterial pressure. Basal ACE activity in kidney, lung, and arterial plasma of such rats was in 5, 3 and 1.7-fold more than in mesotonic rats, respectively. I.v. administration of carbachol (10(-9) and 10(-8) mol/kg) produced decrease in arterial plasma ACE activity in dose-dependent manner (from 40 to 20 nmol/ml.min) and diminution of lung ACE activity (on 18%). It is suggested that carbachol produces an inactivation and inhibition of ACE secretion by lung and lung ACE biosynthesis in sympathetic overactivity rats. A pattern of ACE activity in plasma, kidney and lung is determined by the sympathetic-parasympathetic balance.
Fedorov
V I
VI
Institute of Laser Physics, Siberian Branch of the Russian Acad. Sci., Russia.
Cherkasova
O P
OP
D000109:Acetylcholine / Q000031:analogs & derivatives*; D000818:Animals; D001158:Arteries; D002217:Carbachol / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008168:Lung / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects* / Q000378:metabolism; D010949:Plasma / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*
D002217:Carbachol; D007703:Peptidyl-Dipeptidase A; D000109:Acetylcholine; D003345:Corticosterone
Vliianie stabil'nogo analoga atsetilkholina na aktivnost' angiotenzinprevrashchaiushchego fermenta legkogo, pochki i plazmy arterial'noĭ krovi u krys a povyshennoĭ simpaticheskoĭ aktivnost'iu.