[Preventive action of nicotinamide on the pancreatic antioxidant system in experimental streptozotocin diabetes].
The pancreatic antioxidant system and the effect of the pretreatment with 500 mg/ kg b.w. i.p. nicotinamide were studied in male mice (CBA/J x C57BL/6J)F1 with low-dose streptozotocin-induced diabetes (50 mg/kg b.w. x 5 days). Nicotinamide prevented the development of basal hyperglycaemia, hypoinsulinemia and the growth of superoxide dismutase activity without any impact on the elevated glutathione peroxidase activity and the increase in lipid hydroperoxide level.
Nikulina
M A
MA
Ukrainian Research Institute of Pharmacotherapy of Endocrinous Diseases, Kharkov.
Poltorakh
V V
VV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009536:Niacinamide / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology
D000975:Antioxidants; D009536:Niacinamide
Preventivnoe deĭstvie nikotinamida na antioksidantnuiu sistemu podzheludochnoĭ zhelezy pri eksperimental'nom streptozototsinovom diabete.