Algorithmic analysis of in vitro chemotherapy against Pneumocystis carinii.
The development of in vitro experimental chemotherapy against P.carinii has been hindered by the lack of efficient methods for continuous cultivation of the microorganism. Various short-term systems, allowing the production of infectious forms of Pneumocystis, can be employed for in vitro experimental chemotherapy. The purpose of the present study is to describe a statistically relevant algorithmic model for the evaluation of P.carinii in short-term in vitro culture and drug screening.
Atzori
C
C
II Div. Inf. Dis., L. Sacco Hosp. Milan, Italy.
Agostoni
F
F
Angeli
E
E
Cargnel
A
A
Drago
L
L
Gismondo
M R
MR
D000465:Algorithms; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D011010:Pneumocystis / Q000187:drug effects*; D051381:Rats
D000935:Antifungal Agents