title: Pulmonary invasive aspergillosis in patients infected with the human immunodeficiency virus: report of two cases.
abstract: Patients infected with the human immunodeficiency virus (HIV) have an increased frequency of invasive aspergillosis. We report two cases of invasive pulmonary aspergillosis in patients infected with HIV. Patients had less than 10 CD4 (helper cell) cells/mm3 (2/2), presented with fever (2/2), dyspnea (1/2), and abnormal chest radiograph (2/2). Diagnosis was established by transbronchial biopsy (1/2) and autopsy (1/2). Patients died in spite of treatment with intravenous deoxycholate amphotericin B. Prognosis of invasive pulmonary aspergillosis among patients infected with HIV remains dismal, even with aggressive antifungal treatment.
authors.affiliation: Department of Medicine, The Miriam Hospital, Brown University School of Medicine, Providence, RI 02906, USA.
authors.forename: E
authors.initials: E
authors.lastname: Mylonakis
authors.forename: M D
authors.initials: MD
authors.lastname: Mileno
authors.forename: T
authors.initials: T
authors.lastname: Flanigan
authors.forename: D F
authors.initials: DF
authors.lastname: De Orchis
authors.forename: J
authors.initials: J
authors.lastname: Rich
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D011379:Prognosis
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B