title: Placental metastasis from maternal primitive neuroectodermal tumor.
abstract: The occurrence of placental metastasis from maternal primitive neuroectodermal tumor (PNET) is extremely rare. A 33-year-old woman at 33 weeks' gestation was admitted to the hospital. She died of the disease on hospital day 28 because the unresectable tumor was located over a wide area of the retroperitoneum. A neonate was delivered by a caesarean section without evidence of disease and has survived to 1 year of age. Pathologically, the tumor consisted of monotonous small round cells with a high nuclear cytoplasmic ratio, including several pseudorosettes and Homer-Wright-type rosettes. On immunohistochemical examination, the tumor cells were positively stained for neuron-specific enolase. Microscopically, the placenta showed intervillous metastasis from the maternal PNET. This case may be the first one of placental metastasis from PNET ever reported in the literature.
authors.affiliation: Department of Radiology and Radiation Oncology, School of Medicine, Gunma University, Maebashi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
authors.forename: N
authors.initials: N
authors.lastname: Mitsuhashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ibuki
authors.forename: T
authors.initials: T
authors.lastname: Joshita
authors.forename: T
authors.initials: T
authors.lastname: Fukusato
authors.forename: H
authors.initials: H
authors.lastname: Niibe
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018242:Neuroectodermal Tumors, Primitive / Q000556:secondary*; D010922:Placenta Diseases / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology; D011256:Pregnancy Outcome; D012186:Retroperitoneal Neoplasms / Q000556:secondary*