Histologic evaluation of preventive measures for scald injury on the peritoneo-serosal surface due to intraoperative hyperthermic chemoperfusion for patients with gastric cancer and peritoneal metastasis.
To histologically assess the preventive efficacy of cimetidine against scald injury on the peritoneo-serosal surface during intraperitoneal hyperthermic chemoperfusion (IHCP) for advanced gastric cancer, a randomized histologic study using cimetidine, a histamine H2-receptor antagonist, was performed for 20 patients with advanced or recurrent gastric cancer and peritoneal metastasis. Cimetidine 50 mg/kg was administered intravenously to 10 patients just prior to the IHCP (cimetidine group), and the remaining 10 patients underwent the IHCP without cimetidine (control group). The background factors and IHCP treatments of these two groups were nearly the same. Although the antitumour efficacy of the IHCP was not histologically different between the two groups, the histological analysis revealed that the peritoneo-serosal surface in the cimetidine group was protected against scald injury, compared with the control group. This finding suggests that pre-IHCP cimetidine is of great benefit for protecting the peritoneo-serosal surface from scald injury due to IHCP.
Fujimoto
S
S
Social Insurance Funabashi Central Hospital, Japan.
Takahashi
M
M
Kobayashi
K
K
Mutou
T
T
Toyosawa
T
T
Izawa
E
E
Numai
T
T
Kondoh
F
F
Ohkubo
H
H
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy; D002927:Cimetidine / Q000627:therapeutic use; D004358:Drug Therapy / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006651:Histocytochemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007583:Jejunum / Q000166:cytology / Q000187:drug effects / Q000293:injuries; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010477:Perfusion / Q000379:methods; D010537:Peritoneum / Q000166:cytology / Q000187:drug effects / Q000293:injuries; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013696:Temperature
D000970:Antineoplastic Agents; D006635:Histamine H2 Antagonists; D002927:Cimetidine