title: Frequency and methodologic rigor of quality-of-life assessments in the critical care literature.
abstract: OBJECTIVE
  To present a framework for describing/measuring quality of life (QOL) and health-related quality of life (HRQL), and to assess the frequency and methodologic rigor of QOL studies in the adult critical care literature.
  
  
  METHODS
  Computerized bibliographic search of published research, manual search of key intensive care unit (ICU) journals, and citation review of relevant articles.
  
  
  METHODS
  We manually searched Critical Care Medicine, American Journal of Respiratory and Critical Care Medicine, and Intensive Care Medicine for the period January 1992 to July 1995 to assess the frequency of published QOL studies. Combined with a computerized bibliographic search, we found 64 studies that met our criteria that reported on patient-related outcomes (other than mortality) after hospital discharge.
  
  
  METHODS
  We abstracted data on the nature of each study, the instruments used to measure QOL, and the methodologic rigor of the QOL assessments. We evaluated each study using criteria we developed to assess the validity of HRQL measurements.
  
  
  RESULTS
  In our manual search, we found 1,073 articles relevant to the practice of adult critical care. Of these, 19 (1.7%)/1073 included QOL measurements. Combined with our comprehensive search strategy, we found 64 papers that evaluated QOL in ICU patients. These papers dealt primarily with issues of: prognosis (32 [50%]), resource allocation (23 [36%]), and clinical prediction (9 [14%]). We found no randomized trials that included post-ICU QOL as an outcome. With respect to the validity of the HRQL assessments, 63/64 (98%) studies evaluated aspects of patients' lives that we considered important. Thirty-three (52%) studies were limited in scope to specific aspects of HRQL, and 31 (48%) studies covered broad areas of HRQL. In these 64 studies, there were 108 different instruments used. The reliability and validity of the instruments used were reported in 7 (6%) and 15 (14%) cases, respectively. For 81 (75%) instruments, the investigators either explained the results or used informative, qualitative descriptors whose interpretation was self-evident. Overall, three (5%) of the included studies met all four methodologic criteria to assess the validity of HRQL assessments.
  
  
  CONCLUSIONS
  QOL assessments occur infrequently in the ICU literature and are of limited methodologic quality. More studies using valid and reliable instruments are necessary to document the long-term QOL of critically ill patients, especially those at risk of a "poor" outcome.
authors.affiliation: Department of Medicine, Queen's University, Kingston, ON, Canada.
authors.forename: D K
authors.initials: DK
authors.lastname: Heyland
authors.forename: G
authors.initials: G
authors.lastname: Guyatt
authors.forename: D J
authors.initials: DJ
authors.lastname: Cook
authors.forename: M
authors.initials: M
authors.lastname: Meade
authors.forename: E
authors.initials: E
authors.lastname: Juniper
authors.forename: L
authors.initials: L
authors.lastname: Cronin
authors.forename: A
authors.initials: A
authors.lastname: Gafni
mesh_terms: D000328:Adult; D015706:Bibliometrics; D003422:Critical Care; D006801:Humans; D017063:Outcome Assessment, Health Care; D011788:Quality of Life