Effect of insulin therapy on body fat distribution in NIDDM patients with secondary sulfonylurea failure: a preliminary report.
To clarify the influence of insulin therapy on body weight and fat distribution, we compared these parameters in five non-insulin dependent diabetes mellitus (NIDDM) patients, with secondary sulfonylurea failure, before and after insulin therapy. Body weight increased significantly after instituting insulin treatment. However, the visceral to subcutaneous fat (V/S) ratio decreased significantly due to a marked increase in S-fat without a change in V-fat. Insulin therapy necessitated by sulfonylurea failure does not appear to accelerate the atherogenic process in NIDDM patients as there is no increase in visceral fat.
Takei
I
I
Department of Internal Medical, Keio University School of Medicine, Tokyo, Japan.
Takayama
S
S
Yamauchi
A
A
Nakamoto
S
S
Kitamura
Y
Y
Katsukawa
F
F
Yamazaki
H
H
Saruta
T
T
Inoue
S
S
D000273:Adipose Tissue; D001823:Body Composition; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D017211:Treatment Failure; D015430:Weight Gain
D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds