Antiplasmodial activity of mono- and dimeric carbazoles.
A series of mono- and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 micrograms/ml. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).
Bringmann
G
G
Institut für Organische Chemie der Universität, Würzburg, Germany. bringman@chemic.uni-wuerzburg.de
Ledermann
A
A
Holenz
J
J
Kao
M T
MT
Busse
U
U
Wu
H G
HG
François
G
G
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D013057:Spectrum Analysis
D000962:Antimalarials; D002227:Carbazoles