title: Myocardial damage during percutaneous transluminal coronary angioplasty as evidenced by troponin T measurements.
abstract: OBJECTIVE
  The present study was undertaken to assess the effect of balloon inflation during percutaneous transluminal coronary angioplasty on markers of myocardial damage.
  
  
  RESULTS
  Seventy-five patients undergoing elective percutaneous transluminal coronary angioplasty were evaluated with serum creatine kinase MB and cardiospecific troponin T before and 1 and 4 days after the procedure. On day 1, 28% of the patients had increased cardiospecific troponin T values and 18% had increased creatine kinase MB values. On day 4, 24% had increased cardiospecific troponin T values, whereas all creatine kinase MB values were normal. A high degree of correlation between creatine kinase MB and cardiospecific troponin T on day 1, as well as between both markers on day 1 and cardiospecific troponin T on day 4 were found. The increased levels of cardiospecific troponin T on day 4 was significantly correlated with the total balloon inflation time (P < 0.001).
  
  
  CONCLUSIONS
  We conclude that irreversible myocardial damage, as evidenced by increased cardiospecific troponin T values on day 4, occurs in an appreciable number of patients during percutaneous transluminal coronary angioplasty, and that this damage is strongly correlated with the total balloon inflation time.
authors.affiliation: Department of Cardiology, Ullevål University Hospital, Oslo, Norway.
authors.forename: O
authors.initials: O
authors.lastname: Johansen
authors.forename: M
authors.initials: M
authors.lastname: Brekke
authors.forename: J H
authors.initials: JH
authors.lastname: Strømme
authors.forename: V
authors.initials: V
authors.lastname: Valen
authors.forename: I
authors.initials: I
authors.lastname: Seljeflot
authors.forename: O
authors.initials: O
authors.lastname: Skjaeggestad
authors.forename: H
authors.initials: H
authors.lastname: Arnesen
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006335:Heart Injuries / Q000209:etiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014336:Troponin / Q000032:analysis*
chemical_list: D014336:Troponin; D003402:Creatine Kinase