title: Plasminogen activator inhibitor-1 activity is independently related to both insulin sensitivity and serum triglycerides in 70-year-old men.
abstract: Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been discussed as a part of the insulin resistance syndrome. However, it is not clear whether the relationship between PAI-1 and insulin resistance is independent of or mediated by increased triglycerides levels. The aim of this study was to investigate whether PAI-1 activity is associated with insulin sensitivity independently of serum triglycerides (sTG) and of other potential confounders. Seventy-year-old men (n=871), participating in a cohort study undergoing extensive metabolic investigations, had blood samples taken for determination of PAI-1 activity. Insulin sensitivity was determined by the euglycemic hyperinsulinemic clamp. In multivariate correlation and regression analyses, insulin sensitivity was a statistically significant determinant of PAI-1 activity (partial r=-.12; P<.001), independent of sTG, body mass index, waist-hip ratio, and other potential confounders. The levels of sTG were also independently related to PAI-1 activity (partial r=.18; P<.001). The relationships between PAI-1 and insulin sensitivity and sTG were independent of fasting glucose levels. Aggregation of risk factors of the insulin resistance syndrome was associated with increased activity of PAI-1 in men with normal glucose tolerance. We conclude that PAI-1 activity is related to insulin sensitivity and sTG, independently of each other and of other potential confounders, and that increased levels of PAI-1 should be regarded as a component of the insulin resistance syndrome.
authors.affiliation: Department of Geriatrics, Uppsala University, Sweden. liisa.byberg@geriatrik.uu.se
authors.forename: L
authors.initials: L
authors.lastname: Byberg
authors.forename: A
authors.initials: A
authors.lastname: Siegbahn
authors.forename: L
authors.initials: L
authors.lastname: Berglund
authors.forename: P
authors.initials: P
authors.lastname: McKeigue
authors.forename: R
authors.initials: R
authors.lastname: Reneland
authors.forename: H
authors.initials: H
authors.lastname: Lithell
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D015331:Cohort Studies; D015309:Glucose Clamp Technique; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D014280:Triglycerides