The glycoprotein D (US6) homolog is not essential for oncogenicity or horizontal transmission of Marek's disease virus.
RB1BUS6lacgpt, a Marek's disease virus (MDV) mutant having a disrupted glycoprotein D (gD) homolog gene, established infection and induced tumors in chickens exposed to it by inoculation or by contact. Lymphoblastoid cell lines derived from RB1BUS6lacgpt-induced tumors harbored only the mutant virus. These results provide strong evidence that an intact gD homolog gene is not essential for oncogenicity or horizontal transmission of MDV.
Anderson
A S
AS
Delaware Agricultural Experiment Station, Department of Animal and Food Sciences, College of Agricultural Sciences, University of Delaware, Newark 19717-1303, USA.
Parcells
M S
MS
Morgan
R W
RW
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D002472:Cell Transformation, Viral; D002645:Chickens; D003001:Cloning, Molecular; D018562:Disease Transmission, Infectious; D029968:Escherichia coli Proteins; D015870:Gene Expression; D008381:Herpesvirus 2, Gallid / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D007763:Lac Operon; D008223:Lymphoma; D008380:Marek Disease / Q000635:transmission* / Q000821:virology; D016254:Mutagenesis, Insertional; D010430:Pentosyltransferases; D011506:Proteins; D012367:RNA, Viral; D014407:Tumor Cells, Cultured; D014759:Viral Envelope Proteins / Q000235:genetics / Q000502:physiology*
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D011506:Proteins; D012367:RNA, Viral; D014759:Viral Envelope Proteins; C102727:glycoprotein D, Marek's disease virus; D010430:Pentosyltransferases; C071962:Gpt protein, E coli