Noradrenergic response in vas deferens from rats submitted to acute and repeated stress.
1. This work investigated the effects of androgens on the norepinephrine sensitivity of vasa deferentia from rats submitted to acute or repeated stress, as well as the participation of alpha1-adrenoceptors in the response of intact and bisected vasa deferentia from adult normal rats submitted to acute or repeated stress. 2. The acute stress produced subsensitivity to norepinephrine only in intact vasa deferentia from adult normal rats, which was prevented by lack of androgens, suggesting that the sensitivity may be dependent on the physiological level of androgen. 3. No change was observed in intact vas deferens sensitivity to norepinephrine in repeated stress, suggesting the occurrence of adaptation to elevated norepinephrine levels or a mild decrease in androgen levels or both. 4. The changes in sensitivity observed in acute and repeated stress may also be due to alterations in alpha1-adrenergic receptors that are located in the prostatic portion of the vas deferens.
Pereira
O C
OC
Department of Pharmacology, Institute of Bioscience-São Paulo State University (UNESP), Botucatu, Brazil.
Dega
M R
MR
Souza
M S
MS
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000728:Androgens / Q000172:deficiency*; D000818:Animals; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects* / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology*; D014649:Vas Deferens / Q000187:drug effects / Q000503:physiopathology*
D000316:Adrenergic alpha-Agonists; D000728:Androgens; D018340:Receptors, Adrenergic, alpha-1; D009638:Norepinephrine