Synthesis of 5-membered ring-type compounds as potential cholecystokinin receptor ligands.
Imidazolidine-2,4-diones and 1,5-diphenyl tetramic acid derivatives were selected in order to evaluate some 5-membered heterocyclic ring compounds as potential templates for the synthesis of CCK receptor ligands. All the compounds were evaluated in vitro towards both CCK-B and CCK-A receptors.
Pentassuglia
G
G
Glaxo Wellcome S.p.A., Medicines Research Centre, Verona, Italy. GGP7108@ggr.co.uk
Araldi
G L
GL
Donati
D
D
Feriani
A
A
Oliosi
B
B
Pasquarello
A
A
Ursini
A
A
D002478:Cells, Cultured; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D008566:Membranes / Q000378:metabolism; D008958:Models, Molecular; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D011869:Radioligand Assay; D011949:Receptors, Cholecystokinin / Q000187:drug effects*
D007093:Imidazoles; D008024:Ligands; D011760:Pyrrolidinones; D011949:Receptors, Cholecystokinin; C009435:tetramic acid