title: Nutrition in early life and cardiovascular disease.
abstract: Fat-modified diets for children are controversial. Infant nutrition imprints adult lipid metabolism in animals, but evidence is not available for humans. Three intervention trials to reduce total fat, saturated fat and cholesterol intake in children showed small effects on lipid intakes and on serum lipids, but no adverse effects. Serum lipoproteins are associated with coronary artery raised lesions in young adults. Although modifying dietary intakes of children and adolescents appears difficult, changes sufficient to lower plasma cholesterol levels would retard the progression of atherosclerosis and would be safe.
authors.affiliation: Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. hmcgill@icarus.sfbr.org
authors.forename: H C
authors.initials: HC
authors.lastname: McGill
mesh_terms: D000293:Adolescent; D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood*; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D002986:Clinical Trials as Topic; D004041:Dietary Fats / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D018673:Nutrition Policy; D012307:Risk Factors
chemical_list: D004041:Dietary Fats