Non-Hodgkin's lymphoma presenting with prominent splenomegaly--clinicopathologic diversity in relationship to immunophenotype.
Splenomegaly is an uncommon presenting feature of non-Hodgkin's lymphoma. This is a study of 16 cases of non-Hodgkin's lymphoma presenting with prominent splenomegaly, which includes ten B-cell lymphomas and six T-cell lymphomas. There were distinct clinical and morphologic differences between these two immunologic types of splenic lymphomas, the B-cell types being predominantly low grade and occurring in older individuals whereas the T-cell lymphomas were predominantly high grade and occurred in adolescents and young adults.
Nair
S
S
Department of Pathology, Christian Medical College and Hospital, Vellore, India.
Shukla
J
J
Chandy
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000276:immunology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013163:Splenomegaly / Q000209:etiology* / Q000276:immunology / Q000473:pathology