title: Cortical spreading depression induces an LTP-like effect in rat neocortex in vitro.
abstract: We have developed an in vitro model of spreading depression (SD) in rat neocortex. KCl application induced a propagating wave of SD associated with a change of optical lucency and an extracellular negative wave. Both of these were abolished by aminophosphonovaleric acid (100 microM), indicating SD's mediation by NMDA receptors. SD abolished synaptically-mediated field potentials in layer II and this depression was followed by a previously undescribed, sustained LTP-like enhancement of transmission.
authors.affiliation: University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: Footitt
authors.forename: N R
authors.initials: NR
authors.lastname: Newberry
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D013181:Cortical Spreading Depression / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D019579:Neocortex / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate