Allergen gene transfer.
DNA-based immunization induces a biased Th1 immune response, and offers a novel strategy for modulation of the Th2-associated response. Recent studies have provided evidence that antigen-induced allergic responses can be modulated in rodents immunized with plasmid DNAs encoding the sensitizing antigens. Further understanding of the regulatory mechanism involved and optimization of gene transfer/expression systems will assist greatly in proving the clinical utility of this process.
Huang
S K
SK
Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA. skhuang@welchlink.welch.jhu.edu
Chua
K Y
KY
Hsieh
K H
KH
D000276:Adjuvants, Immunologic / Q000235:genetics; D000485:Allergens / Q000235:genetics* / Q000276:immunology; D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D000276:Adjuvants, Immunologic; D000485:Allergens