title: Myocardial ischaemia after coronary artery bypass grafting: early vs late extubation.
abstract: The technique of early extubation after coronary artery bypass grafting is increasing in popularity, but its safety and effect on myocardial ischaemia remain to be established. In a randomized, prospective study, patients undergoing routine elective coronary artery bypass grafting were managed with either early or late tracheal extubation. The incidence and severity of electrocardiographic myocardial ischaemia were compared. Data were analysed from 85 patients (43 early extubation; 42 late extubation). Median time to extubation was 110 min in the early extubation patients and 757 min in the late extubation patients. After correction for randomization bias, there were no significant differences between groups in ischaemic burden, maximal ST-segment deviation, incidence of ischaemia and area under the ST deviation-time curve (integral of ST deviation and time). Similarly, there were no differences between groups in postoperative creatine kinase MB-isoenzyme concentrations and duration of stay in the ICU or hospital. Therefore, this study provides evidence for the safety of early extubation after routine coronary artery bypass grafting.
authors.affiliation: Cardiothoracic Centre Liverpool-NHS Trust.
authors.forename: P D
authors.initials: PD
authors.lastname: Berry
authors.forename: S D
authors.initials: SD
authors.lastname: Thomas
authors.forename: S P
authors.initials: SP
authors.lastname: Mahon
authors.forename: M
authors.initials: M
authors.lastname: Jackson
authors.forename: M A
authors.initials: MA
authors.lastname: Fox
authors.forename: B
authors.initials: B
authors.lastname: Fabri
authors.forename: W I
authors.initials: WI
authors.lastname: Weir
authors.forename: G N
authors.initials: GN
authors.lastname: Russell
mesh_terms: D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology*; D011182:Postoperative Care / Q000379:methods*; D011184:Postoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome