[Nitric oxide synthase in neuroepithelial brain tumors].
Immunohistochemical investigation of NO-synthase in brain astrocytic tumors revealed intense reaction in many tumor cells as well as direct correlation in the intensity of reaction and the degree of tumor anaplasia. Grade I astrocytomas did not show immunoreactivity in contrast to high anaplastic tumors where many cells had positive reaction with a different degree of intensity. Positive immunoreaction was shown in many giant cells. Small cell glioblastomas and oligodendrogliomas were immunonegative. There was a direct correlation between NO-synthase expression and glial fibrillar acidic protein.
Sosunov
A A
AA
N.P. Ogarev Mordovian State University, Saransk, Russia.
Chairkin
I N
IN
Odyvanova
L R
LR
Guski
G
G
Tservos-Navarro
D Zh
DZh
D001254:Astrocytoma / Q000201:enzymology*; D001932:Brain Neoplasms / Q000201:enzymology*; D005909:Glioblastoma / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D019001:Nitric Oxide Synthase / Q000032:analysis*
D019001:Nitric Oxide Synthase
Sintaza okisi azota v neĭroépitelial'nykh opukholiakh golovnogo mozga.