[The role of blockage of various M-cholinoreceptor subtypes in induction of tachycardia in rats].
The mechanism of the effect of M-cholinoblockers on the heart rate was analysed. It is suggested on the basis of this analysis that tachycardia induced in reats by muscarinic antagonists was caused by blockade of ther central M1-cholinoceptors which is accompanied with increase in the tone of the sympathetic branch of the autonomic nervous system.
Kosmachev
A B
AB
Institute of Toxicology, Ministry of Public Health of the Russian Federation, St. Petersburg, Russia.
Lychakov
A V
AV
Saunkina
Iu A
IuA
Fil'ko
O A
OA
Chigareva
S M
SM
D000818:Animals; D001115:Arecoline / Q000633:toxicity; D004006:Dichlorvos / Q000506:poisoning; D006339:Heart Rate / Q000187:drug effects; D018727:Muscarinic Antagonists / Q000633:toxicity*; D011041:Poisoning / Q000517:prevention & control; D051381:Rats; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D011976:Receptors, Muscarinic / Q000187:drug effects*; D013610:Tachycardia / Q000139:chemically induced* / Q000503:physiopathology; D014202:Tremor / Q000139:chemically induced / Q000517:prevention & control
D018727:Muscarinic Antagonists; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D011976:Receptors, Muscarinic; D001115:Arecoline; D004006:Dichlorvos
Rol' blokady otdel'nykh podtipov M-kholinoretseptorov v vozniknovenii takhikardii u krys.