title: Nutrition and acute leukemia in adults: relation between nutritional status and infectious complications during remission induction.
abstract: BACKGROUND
  The purpose of this study was to determine whether nutritional state was related to infectious complications in adult patients with acute leukemia.
  
  
  METHODS
  During first-remission induction therapy (mean, 71 days), the duration of neutropenia, various infections, and fevers were related to changes in body weight and serum albumin concentrations as well as total parenteral nutrition (TPN) in 52 patients receiving standardized anti-infectious treatment.
  
  
  RESULTS
  Severe neutropenia prevailed for 27% and fever for 28% of the induction period. A mean weight loss of 5.1 kg, corresponding to a reduction of body mass index from 23.5 to 21.7, was correlated with the number of days that patients had fever (P = 0.026). Despite a normal serum albumin value at the time of admission, patients had severe hypoalbuminemia (<25 g/L) during 16% of the induction period. The drop in serum albumin was independently related to the weight loss (r = 0.37, P = 0.03). Moreover, the incidence and duration of hypoalbuminemia were significantly correlated with duration of fever (P < 0.0001), diarrhea (P = 0.03), and TPN administration (P = 0.00002).
  
  
  CONCLUSIONS
  Weight loss and severe hypoalbuminemia were common during remission induction for these adult patients with acute leukemia and were closely related to the patients' infections.
authors.affiliation: Department of Medicine, Stockholm Söder Hospital, Sweden.
authors.forename: K M
authors.initials: KM
authors.lastname: Eriksson
authors.forename: T
authors.initials: T
authors.lastname: Cederholm
authors.forename: J E
authors.initials: JE
authors.lastname: Palmblad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007239:Infections / Q000209:etiology*; D015470:Leukemia, Myeloid, Acute / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D009752:Nutritional Status; D018529:Nutritional Support; D010289:Parenteral Nutrition, Total; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000503:physiopathology / Q000628:therapy*; D012074:Remission Induction; D012709:Serum Albumin / Q000378:metabolism; D015431:Weight Loss
chemical_list: D000970:Antineoplastic Agents; D012709:Serum Albumin