title: Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia.
abstract: The effects of consuming foods containing 0 (control), 3.4, 6.8, or 10.2 g psyllium seed husk (PSH)/d for 24 wk on the serum lipid profile were assessed in this randomized, double-blind controlled study. Men and women (n = 286) with LDL-cholesterol concentrations between 3.36 and 5.68 mmol/L (130 and 220 mg/dL) were randomly assigned to one of four treatment groups after following a low-fat diet for > or = 8 wk. At week 24, LDL cholesterol was 3% above baseline in the control group. In the group consuming 10.2 g PSH/d, LDL cholesterol remained below baseline during treatment, with a value 5.3% below that of the control group at week 24 (P < 0.05 compared with the control group). No significant differences were observed in HDL cholesterol or triacylglycerol. Although modest, the effect of 10.2 g PSH/d on LDL cholesterol (relative to the control) persisted throughout the 24-wk treatment period, indicating potential for long-term benefit.
authors.affiliation: Chicago Center for Clinical Research, IL 60610, USA. mdavidson@cccr.com
authors.forename: M H
authors.initials: MH
authors.lastname: Davidson
authors.forename: K C
authors.initials: KC
authors.lastname: Maki
authors.forename: J C
authors.initials: JC
authors.lastname: Kong
authors.forename: L D
authors.initials: LD
authors.lastname: Dugan
authors.forename: S A
authors.initials: SA
authors.lastname: Torri
authors.forename: H A
authors.initials: HA
authors.lastname: Hall
authors.forename: K B
authors.initials: KB
authors.lastname: Drennan
authors.forename: S M
authors.initials: SM
authors.lastname: Anderson
authors.forename: V L
authors.initials: VL
authors.lastname: Fulgoni
authors.forename: L G
authors.initials: LG
authors.lastname: Saldanha
authors.forename: B H
authors.initials: BH
authors.lastname: Olson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D015930:Diet Records; D004043:Dietary Fiber / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011620:Psyllium / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D014280:Triglycerides; D011620:Psyllium