[Excitotoxic cascade and neuroprotection in various stages of cerebral development].
Prevalence of cerebral palsy enhanced dramatically during the last decades in some western countries. Pathophysiology of perinatal brain lesions has been revisited. Etiology seems multifactorial including perfusion failure/hypoxia, preconceptional factors, thyroid hormone and growth factors deficiencies, maternal infections with production of cytokines. Excitatory amino acids and excitotoxic cascade seem to be a common final pathway leading to neural cell death. Pharmacological tools destined to inhibit the excitotoxic cascade have been recently developed and are promising for neonatal "neuroprotection".
Evrard
P
P
Service de Neurologie pédiatrique, CRI INSERM 96-03, Hôpital Robert-Debré, faculté de Médecine Xavier-Bichat, Université de Paris VII.
Marret
S
S
Gressens
P
P
D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D016923:Cell Death; D002547:Cerebral Palsy / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D002648:Child; D018846:Excitatory Amino Acids / Q000378:metabolism*; D005333:Fetus / Q000502:physiology; D006801:Humans; D002534:Hypoxia, Brain / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009498:Neurotoxins / Q000096:biosynthesis
D018846:Excitatory Amino Acids; D018696:Neuroprotective Agents; D009498:Neurotoxins
La cascade excitotoxique et la neuroprotection aux différentes phases du développement cérébral.