Effects of noradrenaline on rate-level function of auditory cortex neurons: is there a "gating" effect of noradrenaline?
To test a potential "gating" effect of noradrenaline (NA) in the auditory cortex, the acoustic threshold was estimated by determining the rate-level function of neurons before, during, and after microiontophoretic application (5-40 nA) of NA. The rationale behind this experiment was that a gating effect should decrease the threshold for acoustic excitatory responses. From 84 recorded neurons, we observed (1) that application of NA increased the threshold for 48 of 84 cells, and (2) that, on average, the slope of the rate-level functions was unchanged. These effects on the threshold are consistent with the fact that the dominant effect of NA on the evoked response is inhibition for 34 of 84 cells; increases in evoked responses were observed for only 14 of 84 cells. GABA application (0-50 nA) also led to increased response threshold for 19 of 24 cells (unaffected, 5 of 24 cells). However, for three cells the effect of GABA application was antagonized by bicuculline application, while on the same cells bicuculline application did not prevent the noradrenergic increase in threshold. The effect induced by NA on the threshold raises questions about the generality of a gating effect of NA in sensory neocortex.
Manunta
Y
Y
Laboratoire de Neurobiologie de l'Apprentissage et de la Mémoire, URA 1491, Université Paris-Sud, Orsay, France.
Edeline
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JM
D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects / Q000502:physiology*; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology; D001931:Brain Mapping; D002138:Calibration; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D007266:Inhibition, Psychological; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D009638:Norepinephrine; D001640:Bicuculline