title: Successful treatment for active cytomegalovirus infection by cytomegalovirus antibody-enriched immunoglobulin in a renal transplant recipient.
abstract: Active cytomegalovirus (CMV) infection was treated successfully by only CMV antibody-enriched immunoglobulin (CMV-IG) in a renal transplant recipient. CMV-IG was injected at 86 mg/kg i.v. twice a day for a total of 16 days (4 plus 12 days, interrupted by a pause of 4 days), followed by weekly i.v. injection of 86 mg/kg (7 weeks). Active CMV infection was diagnosed on the basis of DNAemia in plasma, by a newly developed CMV polymerase chain reaction (PCR) test (AMPLICOR CMV). The disappearance of CMV from plasma was confirmed by this PCR test. It seems that single CMV-IG therapy is worth consideration for the treatment of CMV infection.
authors.affiliation: Department of Laboratory Medicine, Osaka City University Medical School.
authors.forename: M
authors.initials: M
authors.lastname: Hiyoshi
authors.forename: T
authors.initials: T
authors.lastname: Takubo
authors.forename: S
authors.initials: S
authors.lastname: Tagawa
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: N
authors.initials: N
authors.lastname: Tatsumi
mesh_terms: D000914:Antibodies, Viral / Q000008:administration & dosage*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000628:therapy*; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins