Primary B cells essentially lack constitutive NF-kappa B activity.
Based primarily on the analysis of B cell lines, mature B cells are considered distinct from non-B cells and immature B cells by having constitutive nuclear NF-kappaB activity. By their comparison to splenic non-B cells or activated B cells we show here that primary resting B cells lack cell-autonomous NF-kappaB activity. This finding indicates that the role of the transcription factor in B cells is similar to that in other cells, namely a common mediator of activation and stress signals. Whereas the absence of constitutive NF-kappaB activity in mature B cells does not argue against a role of NF-kappaB in B cell development, it does not support the notion of the essential function of the factor in maintaining the unique transcriptional activities in B cells.
Yedidia
Y
Y
The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Ben-Neriah
Y
Y
Jung
S
S
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D008213:Lymphocyte Activation / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000166:cytology; D014158:Transcription, Genetic
D016328:NF-kappa B