Comparison of the safety and efficacy of a combination analgesic Myprodol and Ponstan in the treatment of dental pain.
A comparison of the efficacy of Myprodol, a combination analgesic (Ibuprofen, Paracetamol and Codeine phosphate) and Ponstan (Mefenamic acid) was undertaken in a randomised double blind trial of 52 patients who underwent surgical removal of impacted or unerupted teeth. Pain scores were measured for patients pre- and post operatively by means of a visual analogue scale and data was analysed using the BMPD package on the ISM main frame computer at the Medical Research Council. The results indicated that although Myprodol and Ponstan were equally adequate and well tolerated in the control of post operative dental pain, Myprodol exceeded Ponstan in duration of analgesia and in the degree of pain intensity control experienced by the patient.
Lownie
J F
JF
Department of Surgery, University of the Witwatersrand, Johannesburg.
Lownie
M A
MA
Reinach
S G
SG
D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D003061:Codeine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008528:Mefenamic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D008964:Molar, Third; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology; D014081:Tooth Extraction / Q000009:adverse effects; D014095:Tooth, Impacted / Q000150:complications / Q000601:surgery; D014097:Tooth, Unerupted / Q000150:complications / Q000601:surgery
D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; C113552:Myprodol; D000082:Acetaminophen; D008528:Mefenamic Acid; D003061:Codeine; D007052:Ibuprofen