title: Dual skin testing with Mycobacterium avium sensitin and purified protein derivative to discriminate pulmonary disease due to M. avium complex from pulmonary disease due to Mycobacterium tuberculosis.
abstract: Skin testing with Mycobacterium avium sensitin (MAS) RS 10/2 and purified protein derivative (PPD) was conducted on patients with pulmonary disease due to M. avium complex (MAC) or Mycobacterium tuberculosis (MTB) and no known immunodeficiency. Reactions > or = 5 mm to either MAS or PPD were present in 37 (84%) of 44 MAC patients and 28 (97%) of 29 MTB patients. MAC patients had a mean MAS reaction of 13.8 (+/-8.3) mm and a mean PPD reaction of 3.5 (+/-8.6) mm (P < .001). MTB patients had a mean MAS reaction of 17.9 (+/-9.4) mm and a mean PPD reaction of 22.9 (+/-11.4) mm (P < .001). MAS-dominant skin tests (MAS reaction > or = 5 mm larger than PPD reaction) were present in 32 (73%) of 44 MAC patients and 1 (3%) of 29 MTB patients. MAS-dominant skin tests had a specificity of 97% for discriminating MAC disease from MTB disease.
authors.affiliation: Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA. c.fordham.von.reyn@hitchcock.org
authors.forename: C F
authors.initials: CF
authors.lastname: von Reyn
authors.forename: D E
authors.initials: DE
authors.lastname: Williams
authors.forename: C R
authors.initials: CR
authors.lastname: Horsburgh
authors.forename: A S
authors.initials: AS
authors.lastname: Jaeger
authors.forename: B J
authors.initials: BJ
authors.lastname: Marsh
authors.forename: K
authors.initials: K
authors.lastname: Haslov
authors.forename: M
authors.initials: M
authors.lastname: Magnusson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000941:Antigens; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007428:Intradermal Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015269:Mycobacterium avium Complex / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis*; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D016037:Single-Blind Method; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis*
chemical_list: D000941:Antigens; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C012031:sensitin