[Invasive pulmonary aspergillosis caused by Aspergillus ochraceus].
Invasive pulmonary aspergillosis (IPA) is a frequent complication in patients with severe neutropenia resulting from cytotoxic chemotherapy. In Europe, Aspergillus fumigatus is most common pathogen of IPA. In our case, IPA was recognised in 54 year old female suffering from acute lymphoblastic leukemia with pancytopenia. The patient developed severe granulocytopenia during chemotherapy. Chest radiograph revealed progressive bilateral infiltrations with cavitation. In sputum culture Aspergillus ochraceus was found. The results of precipitating tests were positive for A. ochraceus and A. fumigatus. Treatment with amphotericin B was used successfully leading soon to clinical improvement, yet radiological lesions remained largely unchanged. The patient received itraconazole, which was very effective and caused almost complete regression. Two episodes of IPA recurrence were treated with antifungal therapy with good results.
Wierzbicka
M
M
I Kliniki Gruźlicy i Chorób Płuc, Warszawie.
Podsiadło
B
B
Janczarski
M
M
D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D001235:Aspergillus ochraceus / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D008875:Middle Aged; D010198:Pancytopenia / Q000150:complications; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications; D011859:Radiography; D012008:Recurrence; D013183:Sputum / Q000382:microbiology
D000935:Antifungal Agents; D017964:Itraconazole
Inwazyjna aspergiloza płuc wywołana przez Aspergillus ochraceus.