Minocycline-induced scleral, dental, and dermal pigmentation.
OBJECTIVE
To report a case of scleral discoloration secondary to minocycline therapy.


METHODS
Case report of a patient referred to a university-based cornea and external disease clinic.


RESULTS
The patient had been treated with oral minocycline therapy for adult facial acne for 12 years when she began to develop bilateral blue-gray discoloration of the sclera as well as of the teeth, hard palate, ears, nail beds, and skin.


CONCLUSIONS
Chronic systemic minocycline therapy may induce scleral pigmentary changes. The mechanism of discoloration and the long-term natural history upon cessation of minocycline are unclear.
Morrow
G L
GL
Toronto East General and Orthopedic Hospital.
Abbott
R L
RL
D000152:Acne Vulgaris / Q000188:drug therapy; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005145:Face; D005260:Female; D006801:Humans; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use; D009260:Nail Diseases / Q000139:chemically induced; D010859:Pigmentation Disorders / Q000139:chemically induced*; D015422:Scleral Diseases / Q000139:chemically induced*; D012880:Skin Pigmentation / Q000187:drug effects*; D014075:Tooth Discoloration / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D008911:Minocycline