Glucose intolerance in familial combined hyperlipidaemia. EUFAM study group.
BACKGROUND
Familial combined hyperlipidaemia (FCHL) is a common hereditary disorder. Hypertriglyceridaemia is associated with glucose intolerance and insulin resistance.


METHODS
To study glucose tolerance in FCHL patients with different lipid phenotypes [hypercholesterolaemia (IIA), mixed hyperlipidaemia (IIB), hypertriglyceridaemia (IV)], we investigated 253 family members and 92 spouses arising from 33 well-defined Finnish FCHL pedigrees.


RESULTS
In oral glucose tolerance tests the affected family members had higher values for glucose area under the curve than did non-affected family members [673+/-127 min mmolL(-1), 754+/-145 min mmol L(-1), 846+/-180 min mmol L(-1) and 838+/-183 min mmol L(-1) for phenotypes normal, IIA, IIB and IV respectively; P < 0.001 after adjustment for body mass index, waist circumference and age]. Impaired glucose tolerance and diabetes were more common among affected than non-affected family members (prevalences of normal glucose tolerance 94.0%, 80.0%, 54.3% and 58.5% for phenotypes normal, IIA, IIB and IV).


CONCLUSIONS
Affected FCHL family members were more glucose intolerant than non-affected family members. In men, this disturbance was not related to lipid phenotype nor was it explained by obesity.
Vakkilainen
J
J
Department of Medicine, University of Helsinki, Finland.
Porkka
K V
KV
Nuotio
I
I
Pajukanta
P
P
Suurinkeroinen
L
L
Ylitalo
K
K
Viikari
J S
JS
Ehnholm
C
C
Taskinen
M R
MR
D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D018149:Glucose Intolerance / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D005951:Glucose Tolerance Test; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015995:Prevalence