Protection against post-ischaemic neuronal loss in gerbil hippocampal CA1 by glycineB and AMPA antagonists. Short communication.
Novel antagonists of the glycineB site of the NMDA receptor (MRZ 2/570, MRZ 2/576), and an AMPA receptor antagonist, NBQX were tested in 3-min global ischaemia in gerbils. Untreated animals showed after 14 days a loss of almost 90% of pyramidal neurones in the CA1 region, which was prevented by NBQX, and reduced to 50% by both glycineB antagonists. NBQX produced a delayed, long lasting (up to 24 hr) hypothermia while hypothermia with both glycineB antagonists was transient.
Lazarewicz
J W
JW
Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Gadamski
R
R
Parsons
C G
CG
Danysz
W
W
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002545:Brain Ischemia / Q000473:pathology*; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*; D018009:Receptors, Glycine / Q000378:metabolism*
D018691:Excitatory Amino Acid Antagonists; D018091:Receptors, AMPA; D018009:Receptors, Glycine