Raynaud's phenomenon and acral necrosis after chemotherapy for AIDS-related Kaposi's sarcoma.
Raynaud's phenomenon is a common vascular side effect of chemotherapy drug regimens. Chemotherapy-induced Raynaud's phenomenon leading to acral gangrene has rarely been reported. In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented. Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy. The literature is reviewed, and clinical symptoms, pathophysiology, and treatment options are discussed.
Reiser
M
M
Medizinische Klinik I, University Hospital, Cologne, Germany.
Bruns
C
C
Hartmann
P
P
Salzberger
B
B
Diehl
V
V
Fätkenheuer
G
G
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001761:Bleomycin / Q000009:adverse effects; D005385:Fingers; D005734:Gangrene / Q000139:chemically induced*; D006801:Humans; D008297:Male; D011928:Raynaud Disease / Q000139:chemically induced*; D012514:Sarcoma, Kaposi / Q000188:drug therapy*; D014747:Vinblastine / Q000009:adverse effects / Q000627:therapeutic use; D014750:Vincristine / Q000009:adverse effects / Q000627:therapeutic use
D001761:Bleomycin; D014750:Vincristine; D014747:Vinblastine