[Effects of cerebrolysin on the oxidant homeostasis, the content of microelements and electrolytes in children with minimal brain dysfunction].
In 36 children of 3-8 years old with minimal cerebral dysfunction there were evaluated both concentrations of malonic dialdehyde in blood plasma, erythrocytes and platelets as well as the content of 25 elements (K, Mg, Ca, Na, P, Se, Zn, Co, Cr, Cu, Fe, Mn, Mo, Si, Li, Ni, V, Pb, Sn, Cd, Al, As, Be, Bi, Ti) in hairs. These indices were estimated both before and after course of cerebrolysin therapy (the a dose 2-5 ml intramuscularly during 1 month). There was observed positive influence of the drug on the clinical manifestations of the disease, oxidant and elements homeostasis. Nuclear-emission analysis of the elements' composition of cerebrolysin revealed quite high content in the drug of magnesium, potassium, phosphorus, and selenium which had neuroactive and antioxidant properties.
Gromova
O A
OA
Avdeenko
T V
TV
Burtsev
E M
EM
Skal'nyĭ
A V
AV
Solov'ev
O I
OI
D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000378:metabolism; D001921:Brain / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D004573:Electrolytes / Q000378:metabolism*; D005260:Female; D006197:Hair / Q000737:chemistry*; D006706:Homeostasis; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018697:Nootropic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors; D014131:Trace Elements / Q000032:analysis*
D000596:Amino Acids; D000975:Antioxidants; D004573:Electrolytes; D018697:Nootropic Agents; D014131:Trace Elements; C006952:cerebrolysin; D008315:Malondialdehyde
Vliianie tserebrolizina na oksidantnyĭ gomeostaz, soderzhanie mikroélementov i élektrolitov u deteĭ s minimal'noĭ mozgovoĭ disfunktsieĭ.