Lithium modulates biochemical circadian rhythms in Wistar rats.
We studied the effects of chronic lithium treatment on circadian rhythms of glucose, cholesterol, calcium, potassium, malondialdehyde (MDA), and lactic acid in Wistar rats. Lithium altered the peak time, range, and 24h mean of these biochemical rhythms. Peak times of the circadian rhythms of glucose, calcium, and potassium were delayed by 3h, 6h, and 6h, respectively, whereas circadian rhythms of MDA and lactic acid were advanced by 9h and 3h, respectively, in lithium-treated rats. Delays observed in our experiments would support the hypothesis that lithium's therapeutic effect is to delay overtly fast circadian rhythms. Advances of peak times owing to lithium treatment are discussed.
Subramanian
P
P
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, India.
Menon
V P
VP
Arokiam
F V
FV
Rajakrishnan
V
V
Balamurugan
E
E
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002940:Circadian Rhythm / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008094:Lithium / Q000378:metabolism / Q000494:pharmacology*; D008315:Malondialdehyde / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D019344:Lactic Acid; D008315:Malondialdehyde; D002784:Cholesterol; D008094:Lithium; D005947:Glucose; D011188:Potassium; D002118:Calcium