Antibacterial activity of ciprofloxacin-beta-cyclodextrin complex and its efficacy in dental implants.
Ciprofloxacin forms an inclusion complex with beta-cyclodextrin. The in vitro antibacterial activity of ciprofloxacin on E. coli and Staphylococcus aureus was found better on complexation. The complex was found very effective as a local antibacterial agent when used in dental implants. Significant reduction in the gingival index, probing pocket depth and microbial growth coupled with gain in attachment at the test site compared to control on the 14th day was observed when the implants containing 2.0 mg of the complex equivalent to 0.4 mg of ciprofloxacin was used in clinical trials.
Aithal
K S
KS
College of Pharamaceutical Sciences and College of Dental Surgery, Manipal, India.
Udupa
N
N
Varma
B R
BR
Kurian
R
R
D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000494:pharmacology* / Q000627:therapeutic use; D003505:Cyclodextrins / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004341:Drug Evaluation; D004343:Drug Implants; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000706:statistics & numerical data; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D047392:beta-Cyclodextrins
D000890:Anti-Infective Agents; D003505:Cyclodextrins; D004338:Drug Combinations; D004343:Drug Implants; D047392:beta-Cyclodextrins; C111670:betacyclodextrin, ciprofloxacin drug combination; D002939:Ciprofloxacin; C031215:betadex