A plasmid-mediated beta-lactamase conferring resistance to cefotaxime in a Salmonella typhimurium clone found in St Petersburg, Russia.
Four clinical and two environmental isolates of cefotaxime-resistant Salmonella typhimurium strains collected in St Petersburg, Russia, were studied. Molecular typing demonstrated that they constituted a single clone. The isolates expressed a cefotaxime-hydrolysing beta-lactamase with a pl of 8.4. The enzyme was encoded by a 12 kb plasmid which did not hybridize with TEM, SHV or ampC probes.
Gazouli
M
M
Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
Sidorenko
S V
SV
Tzelepi
E
E
Kozlova
N S
NS
Gladin
D P
DP
Tzouvelekis
L S
LS
D002439:Cefotaxime / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D010957:Plasmids / Q000235:genetics; D012426:Russia; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000187:drug effects* / Q000378:metabolism
D002511:Cephalosporins; D001618:beta-Lactamases; D002439:Cefotaxime