Treatment of enteritis in chronic granulomatous disease with granulocyte colony stimulating factor.
BACKGROUND
In several diseases there is a relation between deficiency of neutrophil granulocytes and granulomatous lesions. Recently, in glycogen storage disease type Ib, this relation has been supported by the beneficial effect of treatment of enteritis with granulocyte-macrophage colony stimulating factor.


OBJECTIVE
To investigate whether chronic granulomatous disease could be treated according to the same principle.


METHODS
Inflammatory lesions were monitored in two brothers with chronic granulomatous disease demonstrated by very low superoxide production in neutrophil granulocytes. The two patients were treated with recombinant human granulocyte colony stimulating factor on three occasions when the disease was active.


RESULTS
In one patient, remission of an inflamed stenosis of the colon sigmoideum was shown by granulocyte scintigraphy after one month of treatment with granulocyte colony stimulating factor. In the other patient, remission of colon disease of later of a non-malignant tumor in the right lung hilum was shown by colonoscopy and computed tomography scans respectively.


CONCLUSIONS
Remission of inflammatory lesions in two brothers with chronic granulomatous disease was induced by granulocyte colony stimulating factor on three occasions. The mechanism for this effect is now known. The result is similar to the response found in patients with leucocyte deficiency due to glycogen storage disease type Ib.
Myrup
B
B
Department of Medicine A, Rigshospitalet, Denmark.
Valerius
N H
NH
Mortensen
P B
PB
D000328:Adult; D003092:Colitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D003113:Colonoscopy; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006098:Granulocytes / Q000000981:diagnostic imaging; D006105:Granulomatous Disease, Chronic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D008297:Male; D011877:Radionuclide Imaging; D011994:Recombinant Proteins; D014057:Tomography, X-Ray Computed
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor