[The effect of the delta sleep-inducing peptide on NMDA-induced seizure activity in rats].
The ED100 of the NMDA inducing clonic seizures (0.53 mcg) or tonic extension of forelimbs (5.02 mcg) increased their efficiency 2.3-fold and 4.46-fold, resp., due to the delta-sleep-inducing peptide administration in rats. The data obtained suggests a neuroprotective effect of the peptide on agonists of excitatory amino acid receptors action.
Shandra
A A
AA
State Medical University, Odessa, Ukraine.
Godlevskiĭ
L S
LS
Brusentsov
A I
AI
Karliuga
V A
VA
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D003701:Delta Sleep-Inducing Peptide / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008845:Microinjections; D016202:N-Methylaspartate / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D000927:Anticonvulsants; D018690:Excitatory Amino Acid Agonists; D016202:N-Methylaspartate; D003701:Delta Sleep-Inducing Peptide
Vliianie del'ta-son indutsiruiushchego peptida na sudorozhnuiu aktivnost', vyzvannuiu NMDA u krys.