[The anti-aggregatory effect of chloramine derivatives of amino acids on platelets in the presence of plasma].
Rabbit platelet aggregation induced by ADP is suppressed equally by the group of the chloramine derivatives of uncharged amino acid with the high molecular masses (N-chlorphenylalanine, N-chlorglutamine, N-chlorleucine). The effects of the derivatives of other uncharged amino acids are different, the inhibition degree increasing sharply at the decrease of molecular mass of amino acid chloramines. Ratio of the rate constant for the reaction of these chloramines with platelets and the rate constant for the reaction with plasma components raises exponentially at the molecular mass reduction.
Murina
M A
MA
Russian State Medical University, Ministry of Health of Russia, Moscow.
Roshchupkin
D I
DI
Kravchenko
N N
NN
Sadovnikov
V B
VB
Sergienko
V I
VI
D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002700:Chloramines / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits
D000596:Amino Acids; D002700:Chloramines; D010975:Platelet Aggregation Inhibitors; C030816:chloramine
Protivoagregatsionnoe deĭstvie khloraminovykh proizvodnykh aminokislotna trombotsity v prisutstvii plazmy krovi.