title: Locally applied transdermal nitrate patches for the treatment of ischaemic rest pain.
abstract: Patients with severe peripheral vascular disease may suffer considerable pain which can be difficult to control with conventional analgesics. We sought to assess the analgesic effect of transdermal nitrate patches in such patients. A prospective trial was performed in 15 patients with ischaemic rest pain due to atherosclerotic peripheral vascular disease. Pain control and oral analgesic requirement were assessed. Fourteen of the 15 had a good or moderate response to the nitrate patches with a subsequent reduction in oral analgesic requirement. The patients with primarily small vessel disease had the greatest improvement in pain control. We conclude that topical nitrates may be used to provide rapid and safe analgesia for patients with ischaemic rest pain.
authors.affiliation: Renal Unit, Hull Royal Infirmary, UK.
authors.forename: S
authors.initials: S
authors.lastname: Fletcher
authors.forename: M
authors.initials: M
authors.lastname: Wright
authors.forename: A
authors.initials: A
authors.lastname: Wilkinson
authors.forename: M
authors.initials: M
authors.lastname: Farr
authors.forename: L
authors.initials: L
authors.lastname: Sellars
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005121:Extremities / Q000098:blood supply*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D011446:Prospective Studies; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin