Effects of indomethacin, cisplatin and delta 12-prostaglandin J2 on growth of oral squamous carcinoma cells.
The effect of indomethacin, cisplatin and delta 12-prostaglandin J2 (PGJ2) on the inhibition of cell growth and DNA Synthesis (i.e. cell proliferation), was evaluated in vitro on human oral squamous carcinoma cells(SCC-25). The rank order of their inhibitory potency at 10(-5) M was delta 12-PGJ2 > cisplatin > indomethacin. However, delta 12-PGJ2 at 10(-7) and 10(-6) M induced a significant stimulatory effect on cell growth as well as DNA synthesis. The sefindings suggest that delta 12-PGJ2 is a promising novel chemotherapeutic agent for oral cancer and potential candidate for future clinical investigations.
el Attar
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Hormone Research Laboratory, University of Missouri-Kansas City, Schools of Dentistry and Medicine 64108, USA.
Virji
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D002294:Carcinoma, Squamous Cell; D002455:Cell Division / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D002945:Cisplatin / Q000633:toxicity*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007213:Indomethacin / Q000633:toxicity*; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000633:toxicity; D011465:Prostaglandins, Synthetic / Q000633:toxicity; D014062:Tongue Neoplasms; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm; D011465:Prostaglandins, Synthetic; C040810:9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2; D002945:Cisplatin; D015230:Prostaglandin D2; D007213:Indomethacin