Pneumocystis carinii and the immune response in disease.
Pneumocystis carinii causes serious disease in immunocompromised patients, notably in AIDS patients. Our understanding of the biology of this fungus is advancing but still incomplete. Protective immunity against P. carinii is mediated by CD4+ T cells in the immunocompetent host, but precise resistance mechanisms remain to be determined.
Hanano
R
R
Dept of Immunology, University of Ulm, Germany. ralph.hanano@medizin,uni-ulm.de
Kaufmann
S H
SH
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D051379:Mice; D011010:Pneumocystis / Q000145:classification; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000276:immunology* / Q000473:pathology