title: The genome sequence of herpes simplex virus type 2.
abstract: The genomic DNA sequence of herpes simplex virus type 2 (HSV-2) strain HG52 was determined as 154,746 bp with a G+C content of 70.4%. A total of 74 genes encoding distinct proteins was identified; three of these were each present in two copies, within major repeat elements of the genome. The HSV-2 gene set corresponds closely with that of HSV-1, and the HSV-2 sequence prompted several local revisions to the published HSV-1 sequence (D. J. McGeoch, M. A. Dalrymple, A. J. Davison, A. Dolan, M. C. Frame, D. McNab, L. J. Perry, J. E. Scott, and P. Taylor, J. Gen. Virol. 69:1531-1574, 1988). No compelling evidence for the existence of any additional protein-coding genes in HSV-2 was identified.
authors.affiliation: MRC Virology Unit, Institute of Virology, Glasgow, United Kingdom. a.dolan@vir.gla.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Dolan
authors.forename: F E
authors.initials: FE
authors.lastname: Jamieson
authors.forename: C
authors.initials: C
authors.lastname: Cunningham
authors.forename: B C
authors.initials: BC
authors.lastname: Barnett
authors.forename: D J
authors.initials: DJ
authors.lastname: McGeoch
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D004265:DNA Helicases / Q000235:genetics; D019915:DNA Primase; D004279:DNA, Viral; D005814:Genes, Viral; D016679:Genome, Viral; D018259:Herpesvirus 1, Human / Q000235:genetics; D018258:Herpesvirus 2, Human / Q000235:genetics*; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014760:Viral Fusion Proteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; C105843:ICP47 protein, Herpes simplex virus; D017874:Immediate-Early Proteins; C078035:UL36 protein, Human herpesvirus 1; C085822:VP13-14 protein, herpes simplex virus type 1; C442523:VP5 protein, Herpes simplex virus type 1; D014760:Viral Fusion Proteins; D014764:Viral Proteins; D019915:DNA Primase; C062021:helicase-primase, Human herpesvirus 1; D004265:DNA Helicases