Cell death in the nervous system.
Programmed cell death is an important process in many types of cell. In the central nervous system of vertebrates, up to 50% of neurons die during development. The fact that in many cases neuronal cell death depends on macromolecular synthesis suggests that there is a genetic program that must be activated for cell death to occur. In this review, general features of cell death are discussed; in addition, the role of putative death-associated genes is outlined. Finally, the influence of neurotrophic factors on cell death is described.
Mahalik
T J
TJ
Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver, USA.
Owens
G P
GP
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology*; D009420:Nervous System / Q000166:cytology*; D009474:Neurons / Q000166:cytology; D014714:Vertebrates / Q000033:anatomy & histology*
D009414:Nerve Growth Factors