Active sensitization and occupational allergic contact dermatitis caused by para-tertiary-butylcatechol.
Para-tertiary-butylcatechol (PTBC) is a rare allergen which is used in the rubber, paint and petroleum industries. We present 9 patients who were sensitized to PTBC and examined at the Finnish Institute of Occupational Health (FIOH) between 1974 and 1995. 3 of the patients had been exposed to PTBC in their work. 2 of them also had allergic reactions to para-tertiary-butylphenol (PTBP)-formaldehyde resin and to PTBP. 5 of the patients became sensitized to PTBC from patch testing. PTBC was found to be one of the most common causes of active sensitization in our clinic. Accordingly, at the FIOH, the patch test concentration of PTBC was lowered to 0.25% and this lower concentration is recommended for general use.
Estlander
T
T
Finnish Institute of Occupational Health, (FIOH), Helsinki, Finland.
Kostiainen
M
M
Jolanki
R
R
Kanerva
L
L
D000269:Adhesives / Q000009:adverse effects; D000328:Adult; D000975:Antioxidants / Q000009:adverse effects*; D002396:Catechols / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D009783:Dermatitis, Occupational / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D005029:Ethylenediamines / Q000009:adverse effects; D005260:Female; D005387:Finland / Q000453:epidemiology; D005557:Formaldehyde / Q000009:adverse effects; D006801:Humans; D007114:Immunization; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects / Q000331:legislation & jurisprudence / Q000592:standards; D010328:Patch Tests; D010636:Phenols / Q000009:adverse effects / Q000737:chemistry; D010655:Phenylenediamines / Q000009:adverse effects; D010969:Plastics / Q000009:adverse effects; D012116:Resins, Plant / Q000009:adverse effects; D013997:Time Factors
D000269:Adhesives; D000975:Antioxidants; D002396:Catechols; D005029:Ethylenediamines; D010636:Phenols; D010655:Phenylenediamines; D010969:Plastics; D012116:Resins, Plant; D005557:Formaldehyde; C038096:tert-butylcatechol; C031234:ethylenediamine; C014627:N-isopropyl-N-phenyl-4-phenylenediamine; C006862:butylphen