Diffuse Lewy body disease.
Diffuse Lewy body disease (DLBD) has been studied from various viewpoints, and although clinical diagnostic criteria for DLBD have been proposed, the diagnosis remains difficult. It has been reported that DLBD is the second most frequent degenerative dementia among the elderly, following Alzheimer-type dementia. Many DLBD cases, however, are clinically misdiagnosed. Therefore, the search for diagnostic markers for DLBD must continue. Very recently, "dementia with Lewy bodies" (DLB) was proposed as a generic term including DLBD and similar disorders. Cortical Lewy bodies are the most important pathological marker for diagnosis of DLB. At this time, however, the mechanism of cortical Lewy body formation is yet to be disclosed.
Kosaka
K
K
Department of Psychiatry, Yokohama City University, Yokohama, Kanagawa.
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D010300:Parkinson Disease / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000378:metabolism
D001057:Apolipoproteins E; D011978:Receptors, Nicotinic; D010450:Endopeptidases