title: Synthesis and evaluation of 1,5-benzodiazepines with bridged cycloalkyl substituents at the N-1 position as potent and selective CCK-B Ligands.
abstract: The synthesis and biological evaluation of 3-ureido and 3-carbamate derivatives of 1,5-benzodiazepines bearing bridged cycloalkyl substituents at N-1 are reported. Their activity as CCK-B receptor ligands is briefly discussed.
authors.affiliation: Glaxo Wellcome S.p.A., Medicines Research Center, Verona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Finizia
authors.forename: D
authors.initials: D
authors.lastname: Donati
authors.forename: G
authors.initials: G
authors.lastname: Pentassuglia
authors.forename: S
authors.initials: S
authors.lastname: Polinelli
authors.forename: G
authors.initials: G
authors.lastname: Tarzia
authors.forename: M E
authors.initials: ME
authors.lastname: Tranquillini
authors.forename: A
authors.initials: A
authors.lastname: Ursini
mesh_terms: D000818:Animals; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008024:Ligands; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*
chemical_list: D008024:Ligands; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; D001569:Benzodiazepines