[Kinase inhibitors of microbial origins].
Microorganisms are beneficial as a source of natural products in the following sense, diversity of species, versatility and variety of substrates, and unique productivity. On top of them, advantage for industrial utilization of microorganisms is that mass production is feasible by culturing them in a fermentation tank. We have been looking for new substances which interact with a molecule involved in biological responses in animal cells. Among them, we summarize our kinase inhibitors isolated from microbial culture in this paper.
Nakanishi
S
S
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Matsuda
Y
Y
D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D002227:Carbazoles / Q000494:pharmacology; D005285:Fermentation; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D026121:Indole Alkaloids; D009219:Myosin-Light-Chain Kinase / Q000037:antagonists & inhibitors*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011423:Propionibacteriaceae; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D000077191:Wortmannin
D000730:Androstadienes; D002227:Carbazoles; D026121:Indole Alkaloids; D000081082:Phosphoinositide-3 Kinase Inhibitors; C049985:staurosporine aglycone; D011493:Protein Kinase C; D009219:Myosin-Light-Chain Kinase; D000077191:Wortmannin