The determination of thymopoietin conformation based on X-ray structure of a discontinuous thymopoietin-like motif of G-actin.
The biologically active conformation of thymopoietin, based on X-ray data reported for discontinuous thymopoietin-like motif of G-actin, is proposed. The conformation is compared with that resulting from the prediction made by the method of Chou & Fasman (Annu. Rev. Biochem. 47, 251-276, 1978) and Rost & Sander (Methods Enzymol. 266, 525-539, 1996).
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Department of Chemistry, University of Wrocław, Poland. SIEMION@CHEM.UNI.WROC.PL
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Szewczuk
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D000199:Actins / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000737:chemistry; D011487:Protein Conformation; D011817:Rabbits; D013946:Thymopoietins / Q000737:chemistry*; D014961:X-Ray Diffraction
D000199:Actins; D013946:Thymopoietins