[Change in distribution of actin and intermediate filaments at early stages of action of epidermal growth factor on A431 cells].
By electron microscopy using immunocytochemical reactions on actin and EGF-R with mild glycerinization it became possible to reveal a thick layer of actin filaments under the apical membrane within the first minutes of the impact of EGF on A431 cells. Keratin fibrils being located near the nucleus are transported apart from the membrane. It is supposed that this process is connected with retardation of capping on principles of competition.
Bobrova
I F
IF
Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
Teslenko
L V
LV
Korolev
E V
EV
D000199:Actins / Q000378:metabolism*; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism / Q000494:pharmacology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D005990:Glycerol; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism*; D011485:Protein Binding; D014407:Tumor Cells, Cultured
D000199:Actins; D004815:Epidermal Growth Factor; D007633:Keratins; D066246:ErbB Receptors; D005990:Glycerol
Izmenenie razpredeleniia aktinovykh i promezhutochnykh filamentov na rannikh srokakh deĭstviia épidermal'nogo faktora rosta na kletki A431.