title: Meningoencephalocele associated with Tripterygium wilfordii treatment.
abstract: We treated a male infant with occipital meningoencephalocele associated with the taking of Tripterygium wilfordii. The infant was delivered normally at 38 weeks of gestation with a huge cystic mass protruding from the occiput. He was diagnosed with occipital meningoencephalocele and cerebellar agenesis. His mother had taken T. wilfordii for rheumatoid arthritis early in her pregnancy. T. wilfordii is a herbal medicine used for rheumatoid arthritis and male contraception. Since its toxicity is high and its use during pregnancy is restricted, it is the most likely cause of this infant's anomalies.
authors.affiliation: Department of Neurosurgery, Showa University, Fujigaoka Hospital, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takei
authors.forename: G
authors.initials: G
authors.lastname: Nagashima
authors.forename: R
authors.initials: R
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Hokaku
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Miyo
authors.forename: J
authors.initials: J
authors.lastname: Asai
authors.forename: Y
authors.initials: Y
authors.lastname: Sanada
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
mesh_terms: D000014:Abnormalities, Drug-Induced; D000015:Abnormalities, Multiple; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002531:Cerebellum / Q000002:abnormalities*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D004677:Encephalocele / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008588:Meningocele / Q000139:chemically induced* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D029757:Tripterygium
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal