Hypotensive reactions associated with platelet transfusions and angiotensin-converting enzyme inhibitors.
OBJECTIVE
To determine the cause of hypotensive reactions associated with platelet transfusions in coronary artery bypass surgery patients.


METHODS
Platelet transfusion reactions that occurred during a 3-month period were retrospectively reviewed.


RESULTS
Eighteen transfusion reactions occurred in 16 patients. Sixteen of the reactions were hypotensive and occurred in 14 patients transfused with platelets through negatively charged bedside leukocyte reduction filters. All 14 patients had received angiotensin-converting enzyme (ACE) inhibitors prior to transfusion.


CONCLUSIONS
Preliminary findings suggest a new type of transfusion reaction associated with the use of negatively charged leukocyte reduction filters during platelet transfusions to patients on ACE inhibitors.
Mair
B
B
Florida Blood Services, Tampa 33612, USA.
Leparc
G F
GF
D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D001781:Blood Component Removal / Q000009:adverse effects; D005260:Female; D005374:Filtration / Q000379:methods; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000009:adverse effects*; D012189:Retrospective Studies
D000806:Angiotensin-Converting Enzyme Inhibitors