title: [The effect of MS-551 on two VT/Vf patients in CABG: a case report].
abstract: Uncontrollable arrhythmia is one of the causes of operative death in CABG. We report two cases of successful treatment of recurrent VT/Vf in CABG operation by MS-551. One case was a 72-year-old male, who had unstable angina and OMI with left ventricular dysfunction (LVEF 24%). After weaning from CPB, the rhythm turned into VT/Vf suddenly. Lidocaine and verapamil were not effective. VT/Vf recurred over the over. The another case was a 52-year-old male, who had OMI and effort angina. He became myocardial infarction during operation. VT/Vf occurred after the weaning from CPB. Lidocaine and amiodarone were of no effect on his VT/Vf. In both cases, intravenous injection of MS-551 promptly stopped VT/Vf. Use of MS-551 was limited mainly on DCM patients. But other antiarrhythmic agents were ineffective on these cases. We have had to continue support circulation for a long time without MS-551. As MS-551 is being used as a trial on medically followed patients, it was unknown how effective clinically on the acute myocardial infarction. In this regard, our cases may suggest a positive answer to that.
authors.affiliation: Department of Cardiovascular Surgery and Cardiology, Heart Institute of Japan, Tokyo Women's Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Uwabe
authors.forename: M
authors.initials: M
authors.lastname: Endo
authors.forename: H
authors.initials: H
authors.lastname: Nishida
authors.forename: Y
authors.initials: Y
authors.lastname: Tomizawa
authors.forename: H
authors.initials: H
authors.lastname: Koyanagi
authors.forename: S
authors.initials: S
authors.lastname: Ohnishi
authors.forename: H
authors.initials: H
authors.lastname: Kasanuki
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000601:surgery*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D011744:Pyrimidinones / Q000627:therapeutic use*
chemical_list: D000889:Anti-Arrhythmia Agents; D011744:Pyrimidinones; C076259:nifekalant