title: Compared effect of a genetically engineered glucagon and hyoscine N-butylbromide on double-contrast barium meal study.
abstract: The aim of this study was to compare the effects of a genetically engineered glucagon (geG) and hyoscine N-butylbromide (HBB) on the quality of double-contrast barium meal (DCBM) study. Two hundred sixty-four patients scheduled for DCBM were randomized to receive intravenously geG 0.25 mg (geG-25), or geG 0.5 mg (geG-50), or HBB 20 mg as hypotonic agent. The evaluation concerned: duration of isolated visualization of the stomach (A); gastric mucosal coating (B); visualization of areae gastricae (C); quality of duodenal cap (D) and loop (E) study; delay, if any, of duodenal study (F). Global significant differences (P from 0.0183 to < 0.0001) were found for A, C, D, and F. GeG-50 allowed the longest isolated gastric visualization (P < 0.0001); geG-25 allowed more extensive visualization of areae gastricae than HBB (P = 0.0006); HBB allowed a better study of duodenal cap (P = 0.0052) and loop (P = 0.0190) than geG-25; geG-50 prolonged the examination time (P < 0.01). No adverse effect was observed with geG within 1 h after DCBM. In conclusion, geG can be safely used as a hypotonic agent in DCBM. When DCBM is focused on the stomach, 0.25 mg of geG is the optimal choice; if DCBM is focused on the duodenum, 0.5 mg of geG (with a prolonged examination time) or 20 mg of HBB (with a less effective study of the stomach) should be used.
authors.affiliation: Department of Radiology, University of Genova, San Martino Hospital, Largo R. Benzi 10, I-16 132 Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cittadini
authors.forename: F
authors.initials: F
authors.lastname: Sardanelli
authors.forename: E
authors.initials: E
authors.lastname: De Cicco
authors.forename: M
authors.initials: M
authors.lastname: Casiglia
authors.forename: T
authors.initials: T
authors.lastname: De Cata
authors.forename: R C
authors.initials: RC
authors.lastname: Parodi
mesh_terms: D000284:Administration, Oral; D001466:Barium Sulfate / Q000008:administration & dosage; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage / Q000009:adverse effects; D003287:Contrast Media / Q000008:administration & dosage; D004386:Duodenum / Q000000981:diagnostic imaging*; D005260:Female; D005753:Gastric Mucosa / Q000000981:diagnostic imaging; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000009:adverse effects; D005818:Genetic Engineering; D005934:Glucagon / Q000008:administration & dosage / Q000009:adverse effects / Q000235:genetics; D006801:Humans; D007038:Hypotonic Solutions / Q000008:administration & dosage / Q000009:adverse effects; D007275:Injections, Intravenous; D008297:Male; D010276:Parasympatholytics / Q000008:administration & dosage / Q000009:adverse effects; D011856:Radiographic Image Enhancement; D013270:Stomach / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media; D005765:Gastrointestinal Agents; D007038:Hypotonic Solutions; D010276:Parasympatholytics; D001466:Barium Sulfate; D002086:Butylscopolammonium Bromide; D005934:Glucagon