[A rare case of BCG vaccinal sepsis in a patient with bladder cancer].
Immunotherapy consisting in intravesical injection of BCG vaccine to a 44-year-old patient with surface relapsing cancer of the bladder resulted in development of sepsis. The vaccine in a dose of 120 mg was injected directly after bougienage of the urethra and catheterization of the bladder. As soon as in 2 h the patient developed chill, fever (38.5 degrees C), and felt bad. The condition progressed, but only in 15 days did the patient applied for medical care. Intensive care including antibiotics and antituberculous drugs in massive doses and repeated sessions of hemoperfusion were of no avail. The patient died with signs of progressive hepatorenal failure. Autopsy confirmed vaccinal mycobacterial sepsis. Intravesical immunotherapy after injury to the urethra was an error, promoting generalization of the infection; another cause of lethal outcome was late application for medical care.
Gorobets
E S
ES
Sviridova
S P
SP
Gromova
E G
EG
Figurin
K M
KM
D000283:Administration, Intravesical; D000328:Adult; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D002295:Carcinoma, Transitional Cell / Q000628:therapy*; D004106:Dilatation; D006801:Humans; D016233:Immunotherapy, Active / Q000009:adverse effects*; D008297:Male; D018805:Sepsis / Q000209:etiology* / Q000401:mortality; D001749:Urinary Bladder Neoplasms / Q000628:therapy*; D014546:Urinary Catheterization
D001500:BCG Vaccine
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