title: Lack of correlation between bronchoconstrictor response and bronchodilator response in a population-based study.
abstract: Bronchodilator and bronchoconstrictor responsiveness have been considered physiological opposites in patients with obstructive airways disease. Provocation challenges have been replaced by bronchodilator tests in the assessment of cases of severe airways obstruction. The aim of this study was to examine the relationship between bronchoconstrictor and bronchodilator responsiveness, and their supposed interchangeability, in a general population. From the Vlagtwedde-Vlaardingen follow-up study, 101 adults were recruited (mean (SD) age 55 (11) yrs, 67 males and 34 females, and 31 were smokers). All completed a questionnaire on airways symptoms. Bronchoconstrictor and bronchodilator responsiveness were assessed with cumulative dose-response curves, using histamine and terbutaline, respectively. Thus, it was possible to relate histamine sensitivity of the airways (the concentration of histamine, at which forced expiratory volume in one second (FEV1) falls by 10% (PC10)) to the maximal bronchodilator response (delta FEV1) and the sensitivity to the bronchodilator (cumulative dose of inhaled terbutaline at which FEV1 increases by 10% (RD10)). Subjects with a bronchoconstrictor response (PC10 < or = 16 mg x mL(-1); n=38) had more respiratory symptoms than those without (n=63) (40 versus 21%) and also lower baseline FEV1 values (90 versus 96% predicted), but had comparable bronchodilator responsiveness. Subjects with a bronchodilator response (delta FEV1 > or = 9% of the predicted value; n=13) did not differ from those without (n=88) for all parameters, including symptoms, allergy and pulmonary function. In those with a bronchoconstrictor response, there was a weak but significant correlation between the PC10 and RD10 (rho=-0.32), but not between PC10 and delta FEV1. This study suggests that bronchoconstrictor and bronchodilator responsiveness are not highly correlated, even in subjects with airways obstruction. Symptoms were associated with the presence of a bronchoconstrictor, but not a bronchodilator, response. We conclude that bronchoconstrictor and bronchodilator responsiveness are two different phenotypic markers that are not interchangeable in epidemiological studies.
authors.affiliation: Dept of Pulmonology, University Hospital, Groningen, The Netherlands.
authors.forename: W R
authors.initials: WR
authors.lastname: Douma
authors.forename: A
authors.initials: A
authors.lastname: de Gooijer
authors.forename: B
authors.initials: B
authors.lastname: Rijcken
authors.forename: J P
authors.initials: JP
authors.lastname: Schouten
authors.forename: G H
authors.initials: GH
authors.lastname: Koëter
authors.forename: S T
authors.initials: ST
authors.lastname: Weiss
authors.forename: D S
authors.initials: DS
authors.lastname: Postma
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001980:Bronchi / Q000187:drug effects*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D013726:Terbutaline / Q000008:administration & dosage*
chemical_list: D001993:Bronchodilator Agents; D006632:Histamine; D013726:Terbutaline