title: Effect of soluble complement receptor type 1 on porphyrin-induced phototoxicity in guinea pigs.
abstract: The effect of recombinant human soluble complement receptor type 1 (sCR1) on the porphyrin-mediated phototoxic reaction was evaluated in guinea pigs. Phototoxicity was induced in the animals by intraperitoneal injection of hematoporphyrin derivative (HpD), followed by irradiation at a wavelength range of 320-450 nm. sCR1 administration decreased CH50 titers in a dose-dependent fashion, while it only moderately suppressed HpD/radiation-induced ear swelling at a high dose. These findings suggest that phototoxic dermatological changes in cutaneous porphyrias are not solely due to complement activation.
authors.affiliation: Dermatology Service, New York Veterans Affair Medical Center, USA.
authors.forename: N
authors.initials: N
authors.lastname: Nomura
authors.forename: H W
authors.initials: HW
authors.lastname: Lim
authors.forename: J L
authors.initials: JL
authors.lastname: Levin
authors.forename: S
authors.initials: S
authors.lastname: Sassa
mesh_terms: D000818:Animals; D015941:Complement Hemolytic Activity Assay; D003169:Complement Inactivator Proteins / Q000494:pharmacology; D017484:Dermatitis, Phototoxic / Q000276:immunology*; D004195:Disease Models, Animal; D004347:Drug Interactions; D004423:Ear / Q000473:pathology; D006168:Guinea Pigs; D006801:Humans; D011166:Porphyrins / Q000494:pharmacology*; D011951:Receptors, Complement / Q000097:blood; D011994:Recombinant Proteins / Q000097:blood / Q000494:pharmacology; D012995:Solubility
chemical_list: D003169:Complement Inactivator Proteins; D011166:Porphyrins; D011951:Receptors, Complement; D011994:Recombinant Proteins