title: Neonatal equine herpesvirus type 1 infection on a thoroughbred breeding farm.
abstract: Of 17 foals born on a Thoroughbred breeding farm between March and April 1995, infection with equine herpesvirus type 1 (EHV-1) was associated with neonatal morbidity in 5 foals, 3 of which died or were euthanized. Morbidity and mortality were associated with pulmonary inflammation, and EHV-1 was identified in the lungs of the 3 foals that died. All neonatal EHV-1 infections occurred in foals of mares housed in the same pasture and barn. No other clinical manifestations of EHV-1 infection (e.g., abortion, neurologic disease, or respiratory disease) occurred during this outbreak. Three foals were treated with acyclovir (1 died, 2 survived), which may have influenced the clinical outcome in the surviving foals.
authors.affiliation: Marion duPont Scott Equine Medical Center, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute, Leesburg, USA. mjmurray@vt.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Murray
authors.forename: F
authors.initials: F
authors.lastname: del Piero
authors.forename: S C
authors.initials: SC
authors.lastname: Jeffrey
authors.forename: M S
authors.initials: MS
authors.lastname: Davis
authors.forename: M O
authors.initials: MO
authors.lastname: Furr
authors.forename: E J
authors.initials: EJ
authors.lastname: Dubovi
authors.forename: J A
authors.initials: JA
authors.lastname: Mayo
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000276:immunology / Q000302:isolation & purification; D006734:Horse Diseases / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D006736:Horses; D008168:Lung / Q000473:pathology / Q000821:virology; D051379:Mice
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral