title: Cyclospora.
abstract: Although Cyclospora infection has been documented in humans worldwide since at least 1977, it is only in the past 2 years that this organism has come into prominence as a result of major foodborne outbreaks in the United States and Canada. Cyclospora causes significant gastrointestinal disease in immunocompetent and immunocompromised hosts and can be successfully treated with trimethoprim-sulfamethoxazole. The infection is under-recognized because our methods for diagnosis are rudimentary and insensitive. The mechanisms by which the parasite causes disease, the range of animal hosts, and the natural reservoir are unknown. Cyclospora is a unique coccidian parasite that has just begun to emerge; as yet, we have no clue as to where it comes from or where it hides.
authors.affiliation: Division of International Medicine and Infectious Diseases, Cornell University Medical College, New York, New York, USA.
authors.forename: R
authors.initials: R
authors.lastname: Soave
authors.forename: B L
authors.initials: BL
authors.lastname: Herwaldt
authors.forename: D A
authors.initials: DA
authors.lastname: Relman
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D005075:Biological Evolution; D003048:Coccidiosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D016783:Eucoccidiida / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity; D006801:Humans; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination