title: Modelling tissue heating with ferromagnetic seeds.
abstract: Interstitial hyperthermia using ferromagnetic seeds demands accurate treatment planning: the seed characteristics and implant geometry must be determined prior to the treatment. A new, finite difference based, seed modelling method is presented. The seed, together with all its surrounding (non-tissue) layers is described as one unit, independent of the tissue grid. The calculation of the seed-tissue interaction is based on the local seed temperature and several tissue temperature samples in the direct vicinity. All the layers between the seed and the surrounding tissue are taken into account in this interaction calculation. The presented implementation describes the analytical solution of the modelled steady-state configurations very accurately. The separation between tissue and seed allows easy assessment of the resulting seed temperature profile which is essential to the optimization of the seed characteristics in treatment planning. The thermal effect due to blood flow in the modelled tissue volume surrounding the seed can be accounted for by inclusion of a heat sink term as well as by inclusion of realistic discrete vasculature.
authors.affiliation: Department of Radiotherapy, University Hospital Utrecht, The Netherlands.
authors.forename: A N
authors.initials: AN
authors.lastname: Kotte
authors.forename: N
authors.initials: N
authors.lastname: van Wieringen
authors.forename: J J
authors.initials: JJ
authors.lastname: Lagendijk
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D005290:Ferric Compounds; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008433:Mathematics; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy; D019736:Prostheses and Implants; D013696:Temperature
chemical_list: D005290:Ferric Compounds; C001215:ferrite