title: Induction of cell proliferation and differentiation in the pancreas of the adult Vervet monkey (Cercopithecus aethiops): preliminary results.
abstract: Cellophane wrapping of the adult Syrian golden hamster pancreas has been found to result in ductular cell proliferation leading to islet regeneration. Injection of cytosol from a cellophane-wrapped pancreas into normal or diabetic hamsters evoked a similar response. In view of the therapeutic potential of the active substance in this cytosol, it was decided to investigate whether a similar response could be achieved in a primate. In normal adult Vervet monkey (Cercopithecus aethiops) pancreas, proliferation is seen only rarely in islet cells and occasionally in duct and acinar cells. Immunohistochemical investigation of normal Vervet monkey pancreas (n = 4) and 14 days (n = 2) and 56 days (n = 1) after cellophane wrapping of the Vervet monkey pancreas revealed a slight increase in proliferation of islet and acinar cells and a larger increase in proliferation of duct cells and in total endocrine cell volume. The results suggest that there is a latent developmental capability in the adult primate pancreas.
authors.affiliation: Experimental Biology Programme, Medical Research Council, Cape Town, South Africa.
authors.forename: S A
authors.initials: SA
authors.lastname: Wolfe-Coote
authors.forename: J
authors.initials: J
authors.lastname: Louw
authors.forename: C W
authors.initials: CW
authors.lastname: Woodroof
authors.forename: J J
authors.initials: JJ
authors.lastname: Heydenrych
authors.forename: D F
authors.initials: DF
authors.lastname: du Toit
mesh_terms: D000818:Animals; D002452:Cell Count; D002454:Cell Differentiation; D002455:Cell Division; D002476:Cellophane; D002522:Chlorocebus aethiops; D007515:Islets of Langerhans / Q000166:cytology; D008297:Male; D010179:Pancreas / Q000166:cytology* / Q000502:physiology; D010183:Pancreatic Ducts / Q000166:cytology; D012038:Regeneration; D013997:Time Factors
chemical_list: D002476:Cellophane