title: Ruptured giant intracranial aneurysms. Part II. A retrospective analysis of timing and outcome of surgical treatment.
abstract: OBJECTIVE
  This retrospective study was made to determine the relationship between surgical timing and outcome in all patients with ruptured giant intracranial aneurysms undergoing surgical treatment at the Mayo Clinic between 1973 and 1996.
  
  
  METHODS
  The authors studied 109 patients, 102 of whom were referred from other medical centers. The ruptured giant aneurysms were 25 to 60 mm in diameter. One hundred five of the patients survived the rupturing of the aneurysm to undergo operation, with direct surgery possible in 84% of cases. Excluding delayed referrals, the average time to surgery after admission to the Mayo Clinic was approximately 4 to 5 days. Patients admitted earlier tended to be in poorer condition, often undergoing earlier operation. On average, surgical treatment was administered later for patients with ruptured aneurysms of the posterior circulation than for those with aneurysms in the anterior circulation. Temporary occlusion of the parent vessel was necessary in 67% of direct procedures, with an average occlusion time of 15.5 minutes. Among surgically treated patients, a favorable outcome was achieved in 72% harboring ruptured anterior circulation aneurysms and in 78% with ruptured posterior circulation lesions.
  
  
  CONCLUSIONS
  The overall management mortality rate was 21.1%, and the mortality rate for surgical management was 8.6%. The authors believe that because of the technical difficulties and risk of rebleeding associated with ruptured giant intracranial aneurysms, timely referral to and well-planned treatment at medical centers specializing in management of these lesions are essential to effect a more favorable outcome.
authors.affiliation: Department of Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Piepgras
authors.forename: V G
authors.initials: VG
authors.lastname: Khurana
authors.forename: J P
authors.initials: JP
authors.lastname: Whisnant
mesh_terms: D000367:Age Factors; D017542:Aneurysm, Ruptured / Q000145:classification / Q000473:pathology / Q000601:surgery*; D001921:Brain / Q000098:blood supply; D002423:Cause of Death; D016009:Chi-Square Distribution; D003250:Constriction; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000145:classification / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D008910:Minnesota; D009460:Neurologic Examination; D010343:Patient Admission; D010347:Patient Care Planning; D012008:Recurrence; D012017:Referral and Consultation; D012189:Retrospective Studies; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000209:etiology; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome