[Digitalis poisoning treated with a specific antidote].
Toxicity by digitalis is a common problem in everyday clinical practice. In this paper three cases of severe poisoning with digitoxin with maximal S-digitoxin levels of 115, 150 and 239 nmol/l are described. All patients received specific digoxin Fab-fragment intravenously. Administration of antidotes resulted in a favourable outcome in all three patients. So far, the use of digoxin-specific antibodies has been limited to a few cases of severe intoxication where life-threatening arrhythmias and hyperkalaemia were present. We discuss whether a more liberal indication should be accepted.
Rykke
E O
EO
Hjertemedisinsk avdeling, Ullevål sykehus, Oslo.
Bredesen
J E
JE
Stokland
O
O
Jacobsen
D
D
D000889:Anti-Arrhythmia Agents / Q000097:blood / Q000276:immunology / Q000506:poisoning*; D000931:Antidotes / Q000008:administration & dosage*; D004074:Digitoxin / Q000097:blood / Q000276:immunology / Q000506:poisoning*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D013406:Suicide, Attempted
D000889:Anti-Arrhythmia Agents; D000931:Antidotes; D007140:Immunoglobulin Fab Fragments; D004074:Digitoxin
Digitalisforgiftning behandlet med spesifikt antidot.