title: Effect of insulin therapy on body fat distribution in NIDDM patients with secondary sulfonylurea failure: a preliminary report.
abstract: To clarify the influence of insulin therapy on body weight and fat distribution, we compared these parameters in five non-insulin dependent diabetes mellitus (NIDDM) patients, with secondary sulfonylurea failure, before and after insulin therapy. Body weight increased significantly after instituting insulin treatment. However, the visceral to subcutaneous fat (V/S) ratio decreased significantly due to a marked increase in S-fat without a change in V-fat. Insulin therapy necessitated by sulfonylurea failure does not appear to accelerate the atherogenic process in NIDDM patients as there is no increase in visceral fat.
authors.affiliation: Department of Internal Medical, Keio University School of Medicine, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Takei
authors.forename: S
authors.initials: S
authors.lastname: Takayama
authors.forename: A
authors.initials: A
authors.lastname: Yamauchi
authors.forename: S
authors.initials: S
authors.lastname: Nakamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kitamura
authors.forename: F
authors.initials: F
authors.lastname: Katsukawa
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Saruta
authors.forename: S
authors.initials: S
authors.lastname: Inoue
mesh_terms: D000273:Adipose Tissue; D001823:Body Composition; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D017211:Treatment Failure; D015430:Weight Gain
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds