[Effects of estrogen monotherapy on breast tissue in the primate model (Macaca fascicularis)].
Much is unknown about the effects of estrogen's on the mammary gland in postmenopausal women today. In a recent study of estrogenmonotherapy 28 adult, surgically postmenopausal female monkeys (Macaca fascicularis) were treated continuously with estradiol or were given only a diet (control group). After 6 months serum levels of estradiol and progesterone, morphometrical, histopathological and immunohistochemical measurements of the mammary gland were performed. In monkeys receiving estradiol the mammary epithel thickness and the mammary epithelial area (as percentage of total breast area) increased. Estradiol induced mammary gland hyperplasia, but we did not see any atypical hyperplasia. Estradiol and progesterone receptors staining in mammary ducts and lobuli increased (not significant). Estradiol induced a mammary gland proliferation (not significant) shown as increased staining for PCNA and Ki67.
Foth
D
D
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Ernst-Moritz-Arndt-Universität Greifswald.
Cline
J M
JM
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D004958:Estradiol / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006965:Hyperplasia; D008252:Macaca fascicularis; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000473:pathology; D011960:Receptors, Estrogen / Q000187:drug effects; D011980:Receptors, Progesterone / Q000187:drug effects
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004958:Estradiol
Effekte einer Ostrogenmonotherapie auf das Mammagewebe am Primatenmodell (Macaca fascicularis).