[Perfluorocarbon emulsions and other corpuscular systems influence on neutrophil activity].
Influence of perfluorodecalin, perfluoromethilcyclohexylpiperidine, perfluorotributylamine emulsions on active oxygen form (AOF) generation by neutrophils has been studied. All investigated emulsions stabilized both proxanol 268 and egg yolk phospholipids inhibited PMA-stimulated neutrophil activity. Castor oil emulsion also inhibited the neutrophil activity. Neutrophil response for chemotactic peptide, was unchanged in the presence of all tested emulsions. We suppose that fast hydrophobic attachment of inert submicrone emulsion particles to cell surface provokes alteration of neutrophil plasma membrane function resulting in a decrease of AOF generation.
Shekhtman
D G
DG
Institute of Cell Biophysics, Russian Acad. Sci., Pushchino, Moscow Region.
Safronova
V G
VG
Sklifas
A N
AN
Alovskaia
A A
AA
Gapeev
A B
AB
Obraztsov
V V
VV
Chemeris
N K
NK
D000818:Animals; D001802:Blood Substitutes; D005466:Fluorocarbons / Q000494:pharmacology*; D051379:Mice; D018375:Neutrophil Activation / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D016897:Respiratory Burst / Q000187:drug effects*
D001802:Blood Substitutes; D005466:Fluorocarbons; D010880:Piperidines; C008807:perfluorotributylamine; C008805:perfluorodecalin
Deĭstvie emul'siĭ perftororganicheskikh soedineniĭ i drugikh korpuskuliarnykh sred na aktivnost' neĭtrofilov.