Minute mixed hepatoma with two components: hepatocellular and cholangiocarcinoma, which developed on liver cirrhosis with HCV.
Mixed type hepatoma with two components, hepatocellular and cholangiocellular carcinoma, is very rare. We encountered a case of a single and minute mixed type hepatoma developing on liver cirrhosis in a patient with persistent hepatitis C viral infection. Histologically, the two-type cancer tissue existed in a nodule with a maximal diameter of approximately 20 mm, and the cholangiocellular carcinoma occupied about 70% of the tumor. The original cell of the mixed type hepatoma is unknown, but this case suggests that a bipotential cell developing into hepatocellular and cholangiocellular carcinoma may be the origin.
Tanaka
T
T
Liver Unit, Tokyo Metropolitan Komagome Hospital, Japan.
Imamura
A
A
Hayashi
S
S
Tsuruta
K
K
Igari
T
T
Koike
M
M
Tanaka
S
S
D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000150:complications / Q000473:pathology*; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D008875:Middle Aged