[Autologous thrombocyte administration in treatment of idiopathic macular foramen].
BACKGROUND
Recent studies have shown the usefulness of pars plana vitrectomy with the use of growth factors in the treatment of macular holes. Autologous platelet concentrates contain many growth factors to stimulate glial wound healing.


METHODS
Nineteen patients with idiopathic macular hole underwent vitrectomy, membrane peeling, air injection and installation of autologous platelet concentrate (0.1 ml). The platelet concentrate contained a mean of 1.8 x 10(9) platelets/ml.


RESULTS
The anatomic success rate in stage 2 macular hole was 100%, in stage 3, 82% and in stage 4, 50%. Visual acuity improved in all patients with stage 2 (two lines) and in 73% of stage 3 at least (one line).


CONCLUSIONS
Platelets are effective in the treatment of macular holes due to the high amount of different growth factors (PDGF, EGF, bFGF, IGF-1) which have a high affinity binding to Müller cells helping to seal the hole by photoreceptor adaption.
Faude
F
F
Universitäts-Augenklinik Leipzig.
Edel
E
E
Dannhauer
M
M
Petzel
C
C
Meier
P
P
Wiedemann
P
P
D000368:Aged; D001804:Blood Transfusion, Autologous; D005260:Female; D006801:Humans; D008297:Male; D017713:Platelet Transfusion; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage; D012167:Retinal Perforations / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
D010982:Platelet-Derived Growth Factor
Autologe Thrombozytenapplikation bei der Behandlung des idiopathischen Makulaforamens.