title: The histidin-rich glycoprotein Pro186/Ser polymorphism is not related to myocardial infarction in the ECTIM study.
abstract: The histidin-rich glycoprotein (HRG) may contribute to coronary heart disease as a consequence of its possible thrombophilic properties. To test this hypothesis we have investigated the Pro186/Ser polymorphism of the HRG gene, which is known to strongly affect plasma HRG levels, in a large multicenter case-control study of myocardial infarction (MI). The results failed to demonstrate any association between the polymorphism and MI or angiographically assessed coronary stenosis.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale SC7, Paris, France.
authors.forename: S M
authors.initials: SM
authors.lastname: Herrmann
authors.forename: O
authors.initials: O
authors.lastname: Poirier
authors.forename: V
authors.initials: V
authors.lastname: Nicaud
authors.forename: J B
authors.initials: JB
authors.lastname: Ruidavets
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: D
authors.initials: D
authors.lastname: Arveiler
authors.forename: G
authors.initials: G
authors.lastname: Luc
authors.forename: L
authors.initials: L
authors.lastname: Bara
authors.forename: F
authors.initials: F
authors.lastname: Cambien
mesh_terms: D000328:Adult; D000483:Alleles; D001798:Blood Proteins / Q000235:genetics; D016022:Case-Control Studies; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D000099053:Histidine-Rich Glycoprotein
chemical_list: D001798:Blood Proteins; D006023:Glycoproteins; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein