The glycoprotein P0 in peripheral gliogenesis.
Recent data show that during development protein zero, P0, the most abundant peripheral nerve myelin protein, is detecable long before myelination. In particular, the expression of P0 in a fraction of migrating neural crest reveals progenitor cell heterogeneity in the developing PNS. Here we review the regulation and potential function of P0 during peripheral gliogenesis.
Sommer
L
L
Institute of Cell Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093 Zürich, Switzerland.
Suter
U
U
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D018993:Myelin P0 Protein / Q000235:genetics / Q000502:physiology*; D017933:Peripheral Nervous System / Q000166:cytology / Q000254:growth & development* / Q000502:physiology*; D012583:Schwann Cells / Q000166:cytology / Q000378:metabolism* / Q000502:physiology*
D018993:Myelin P0 Protein