title: Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3.
abstract: Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein-Barr virus, and environmental conditions may play a role in determining incidence. Molecular studies have implicated a tumor suppressor gene(s) on the short arm of chromosome 3. In this study we provide functional evidence, via monochromosome transfer, for a tumor suppressor gene(s) activity in chromosome 3p21.3.
authors.affiliation: University of California, Irvine, Irvine, CA 92697-4025, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
authors.forename: N E
authors.initials: NE
authors.lastname: Poulos
authors.forename: M L
authors.initials: ML
authors.lastname: Lung
authors.forename: G
authors.initials: G
authors.lastname: Hampton
authors.forename: B
authors.initials: B
authors.lastname: Ou
authors.forename: M I
authors.initials: MI
authors.lastname: Lerman
authors.forename: E J
authors.initials: EJ
authors.lastname: Stanbridge
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008819:Mice, Nude; D018895:Microsatellite Repeats; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured