title: Function of the proximal stomach after Nissen fundoplication.
abstract: BACKGROUND
  After Nissen fundoplication patients frequently report upper abdominal (dyspeptic) symptoms. Theoretically, these symptoms may be the result of changes in function of the proximal stomach as induced by fundoplication.
  
  
  METHODS
  In this case-control study the response of the proximal stomach to both distension by an air-filled bag and a liquid meal were evaluated with the use of a barostat. In 12 patients after fundoplication and 12 healthy volunteers (age- and sex-matched) perception of symptoms was evaluated during both bag distension and liquid meal stimulus.
  
  
  RESULTS
  The minimal distending pressure required to overcome the intra-abdominal pressure was significantly different between patients and controls (mean(s.e.m.) 9.34(0.26) versus 6.73(0.43) mmHg; P < 0.001). There was no difference between groups in either the fasted state, volume-pressure curve (compliance) or total symptom score. After ingestion of the liquid meal the adaptive relaxation in the fundoplication group was significantly less than that in controls (mean(s.e.m.) 150(29.2) versus 244(34.8) ml; P = 0.04).
  
  
  CONCLUSIONS
  This study showed that after Nissen fundoplication compliance of the proximal stomach is no different from that in healthy volunteers. Postprandial relaxation of the proximal stomach is decreased and this abnormality may be involved in the pathogenesis of reported dyspeptic symptoms.
authors.affiliation: Department of Surgery, University Hospital Utrecht, The Netherlands.
authors.forename: B P
authors.initials: BP
authors.lastname: Wijnhoven
authors.forename: G A
authors.initials: GA
authors.lastname: Salet
authors.forename: J M
authors.initials: JM
authors.lastname: Roelofs
authors.forename: A J
authors.initials: AJ
authors.lastname: Smout
authors.forename: L M
authors.initials: LM
authors.lastname: Akkermans
authors.forename: H G
authors.initials: HG
authors.lastname: Gooszen
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004415:Dyspepsia / Q000209:etiology / Q000503:physiopathology; D005260:Female; D018662:Fundoplication / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D010146:Pain / Q000209:etiology; D019518:Postprandial Period; D011312:Pressure; D013270:Stomach / Q000503:physiopathology*; D013272:Stomach Diseases / Q000503:physiopathology / Q000601:surgery*