title: Unique cytomegalovirus intracytoplasmic inclusions in ectocervical cells on a cervical/endocervical smear.
abstract: This case demonstrates unique cytomegalovirus (CMV)-associated intracytoplasmic inclusions in the intermediate squamous cells of a cervical/endocervical smear. These concentric, rod-shaped, perinuclear inclusions were stained for CMV by immunohistochemistry. Cytomegalovirus endocervicitis was also documented on a concurrent cervical biopsy. The finding of these characteristic inclusions on a routine endocervical/cervical smear may provide morphologic evidence for CMV infection in the absence of an adequate endocervical component.
authors.affiliation: Department of Pathology, University of Pennsylvania Medical Center, Philadelphia 19101, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Hunt
authors.forename: Z
authors.initials: Z
authors.lastname: Baloch
authors.forename: A
authors.initials: A
authors.lastname: Judkins
authors.forename: V A
authors.initials: VA
authors.lastname: LiVolsi
authors.forename: K T
authors.initials: KT
authors.lastname: Montone
authors.forename: P K
authors.initials: PK
authors.lastname: Gupta
mesh_terms: D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D003593:Cytoplasm / Q000378:metabolism / Q000473:pathology / Q000821:virology; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007181:Inclusion Bodies, Viral / Q000378:metabolism / Q000473:pathology*; D002575:Uterine Cervicitis / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D014626:Vaginal Smears; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D014764:Viral Proteins