[Free radical oxidation in patients with hypertrophic cardiomyopathy].
As shown by the study of 27 patients with non-obstructive form of hypertrophic cardiomyopathy (HC), this disease is associated with a significant rise in the production of active oxygen forms by leukocytes, significant changes in the activity of enzyme antioxidant defense, unchanged lipid peroxidation, high total antioxidant activity of blood plasma. The patients received a complex of natural antioxidants varying by mechanism of action and glutaminic acid. Antioxidants produced a subjective clinical response, reduced incidence of cardiac arrhythmia, improved exercise tolerance. The response becomes still better in combination of antioxidants with conventional therapeutic tools.
Liusov
V A
VA
Gomzikova
Iu A
IuA
D000328:Adult; D000975:Antioxidants / Q000493:pharmacokinetics / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D015150:Echocardiography, Doppler; D015716:Electrocardiography, Ambulatory; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000097:blood*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000975:Antioxidants; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species
Sostoianie svobodnoradikal'nogo okisleniia u bol'nykh gipertroficheskoĭ kardiomiopatieĭ.