title: Simian Y chromosomes: species-specific rearrangements of DAZ, RBM, and TSPY versus contiguity of PAR and SRY.
abstract: The three human male specific expressed gene families DAZ, RBM, and TSPY are known to be repetitively clustered in the Y-specific region of the human Y Chromosome (Chr). RBM and TSPY are Y-specifically conserved in simians, whereas DAZ cannot be detected on the Y chromosomes of New World monkeys. The proximity of SRY to the pseudoautosomal region (PAR) is highly conserved and thus most effectively stabilizes the pseudoautosomal boundary on the Y (PABY) in simians. In contrast, the non-recombining part of the Y Chrs, including DAZ, RBM, and TSPY, was exposed to species-specific amplifications, diversifications, and rearrangements. Evolutionary fast fixation of any of these variations was possible as long as they did not interfere with male fertility.
authors.affiliation: Institute of Human Genetics and Anthropology, University of Freiburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Gläser
authors.forename: F
authors.initials: F
authors.lastname: Grützner
authors.forename: U
authors.initials: U
authors.lastname: Willmann
authors.forename: R
authors.initials: R
authors.lastname: Stanyon
authors.forename: N
authors.initials: N
authors.lastname: Arnold
authors.forename: K
authors.initials: K
authors.lastname: Taylor
authors.forename: W
authors.initials: W
authors.lastname: Rietschel
authors.forename: S
authors.initials: S
authors.lastname: Zeitler
authors.forename: R
authors.initials: R
authors.lastname: Toder
authors.forename: W
authors.initials: W
authors.lastname: Schempp
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D000075364:Deleted in Azoospermia 1 Protein; D015321:Gene Rearrangement; D000882:Haplorhini / Q000145:classification / Q000235:genetics*; D015186:Hominidae / Q000235:genetics; D006922:Hylobates / Q000235:genetics; D008297:Male; D009687:Nuclear Proteins; D010802:Phylogeny; D016601:RNA-Binding Proteins / Q000235:genetics*; D051876:Sex-Determining Region Y Protein; D013045:Species Specificity; D014157:Transcription Factors; D014998:Y Chromosome
chemical_list: C095668:DAZ1 protein, human; D004268:DNA-Binding Proteins; D000075364:Deleted in Azoospermia 1 Protein; D009687:Nuclear Proteins; C501499:RBMY1A1 protein, human; D016601:RNA-Binding Proteins; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors