[The dynamic indices of the natural cell-mediated cytotoxicity in patients with duodenal peptic ulcer who participated in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station].
As many as 129 patients with duodenal ulcer (DU) who took part in the elimination of the aftereffects of the Chernobyl Nuclear Power Plant breakdown were studied for parameters characterizing the natural cell-mediated cytotoxicity, such as ability to form conjugates with NK-sensitive K-562 target cells, content of conjugate-forming mononuclear cells endowed with known lytic activity, total cytotoxic activity. The functional state of NK-cells is shown to be interrelated with the objective clinical criteria of the condition. Based on the results obtained it can be concluded that alterations in the mechanisms of functioning of NK-cells in the above contingent of examinees can be interpreted as a negative factor in the course of the reparative processes in DU in the remote future after the Chernobyl accident.
Shevchenko
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SV
D001782:Blood Donors; D002908:Chronic Disease; D003602:Cytotoxicity, Immunologic / Q000528:radiation effects*; D004381:Duodenal Ulcer / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000528:radiation effects; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000528:radiation effects; D011210:Power Plants; D018788:Radioactive Hazard Release; D014455:Ukraine
Dinamika nekotorykh pokazateleĭ estestvennoĭ kletochno-oposredovannoĭ tsitotoksichnosti u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki--likvidatorov posledstviĭ avarii na ChAES.