title: [Histogenesis of the giant cells of the osteoclast type in anaplastic thyroid carcinoma].
abstract: One case is reported of amphicrin thyroid carcinoma with signs of A- and C-cell differentiation. This tumor at its early stage had a follicular structure with massive deposits of amyloid in the stroma. In the course of progression the tumor transformed into C-cell anaplastic carcinoma with stromal amyloid deposits in the form of thin fibrils and production of polypeptide hormones and their precursors by tumor cells. The distinctive feature of the tumor metastases was the presence of many giant cells which, as was shown, were amyloid-clasts.
authors.affiliation: State Medical University, Rostov-on-Don.
authors.forename: I S
authors.initials: IS
authors.lastname: Derizhanova
authors.forename: S I
authors.initials: SI
authors.lastname: Sidorenko
authors.forename: E A
authors.initials: EA
authors.lastname: Bardakhch'ian
mesh_terms: D018286:Carcinoma, Giant Cell / Q000473:pathology* / Q000556:secondary; D002454:Cell Differentiation / Q000502:physiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology*
vernacular_title: K voprosu o gistogeneze gigantskikh kletok tipa osteoklastov v anaplasticheskom rake shchitovidnoĭ zhelezy.