Cutaneous infection by Scedosporium apiospermum and its successful treatment with itraconazole.
We report the case of a 42-year-old man with a 13-year history of bilateral faciocervical infiltrative erythema, which had been misdiagnosed as tuberculoderma and which had failed to respond to treatment with adrenal corticosteroids and antituberculotics. On admission to the department, Scedosporium apiospermum was identified on lesion biopsies and fungus cultures as the causative agent and a diagnosis of cutaneous infection by S. apiospermum was made. This is the first report of chronic skin granuloma caused by S. apiospermum in China. Treatment with oral itraconazole (100-400 mg/day) led to clinical cure within 4 months.
Liu
Y F
YF
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zhao
X D
XD
Ma
C L
CL
Li
C X
CX
Zhang
T S
TS
Liao
W J
WJ
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D003881:Dermatomycoses / Q000175:diagnosis* / Q000188:drug therapy; D005148:Facial Dermatoses / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D011541:Pseudallescheria
D000935:Antifungal Agents; D017964:Itraconazole