Increased plasma amyloid beta protein 1-42 levels in Down syndrome.
Amyloid beta protein 1-40 (A beta40) and A beta42 levels were quantitated in plasma from 43 persons with Down syndrome (DS; 26-68 years of age), 43 age-matched normal controls, and 19 non-DS mentally retarded (MR) persons (26-91 years of age) by using a sandwich enzyme linked immunosorbent assay. A beta40 levels were higher in DS and MR than controls, but were similar between DS and MR groups. A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were higher in DS than controls or MR persons. The findings are consistent with those seen in DS brains.
Mehta
P D
PD
Department of Immunology, New York State Institute for Basic Research, Staten Island 10314-6399, USA. pdmehta@worldnet.att.net
Dalton
A J
AJ
Mehta
S P
SP
Kim
K S
KS
Sersen
E A
EA
Wisniewski
H M
HM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000097:blood*; D004314:Down Syndrome / Q000097:blood* / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D006801:Humans; D008607:Intellectual Disability / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D014314:Trisomy
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)