Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506.
Two patients with CsA-associated neurotoxicity developed severe cerebellar swelling and thrombotic thrombocytopenic purpura after switching to FK506 and high-dose corticosteroids. The prodrome of CsA-associated neurotoxicity, TTP and hypertension while receiving FK506, and high-dose corticosteroids could all be implicated in the development of this syndrome. Close monitoring of patients receiving FK506 and high-dose corticosteroids, for the development of TTP is warranted. Early radiological examination should also be considered in such patients to allow early surgical intervention.
Tezcan
H
H
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Zimmer
W
W
Fenstermaker
R
R
Herzig
G P
GP
Schriber
J
J
D000328:Adult; D016026:Bone Marrow Transplantation; D002531:Cerebellum / Q000187:drug effects*; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced*; D016559:Tacrolimus / Q000009:adverse effects*; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus