DNA bending and the curious case of Fos/Jun.
DNA bending has been implicated as an important regulatory mechanism in several processes involving protein-DNA interactions. Various methods for examining intrinsic and protein-induced DNA bending may lead to different conclusions. For the Fos and Jun transcription factors, this has resulted in controversy over whether these factors significantly bend DNA at all.
McGill
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Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute and Children's Hospital, Boston, MA 02115, USA.
Fisher
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D004247:DNA / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000378:metabolism; D004586:Electrophoresis; D005786:Gene Expression Regulation / Q000235:genetics; D016350:Leucine Zippers / Q000502:physiology; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics
D004268:DNA-Binding Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors; D004247:DNA