Immunomodulating therapeutic approaches for multiple sclerosis.
In this review we delineate the rationale for immunotherapy in multiple sclerosis and describe the various levels at which immune intervention, according to a modern model of the immune system organization, is feasible. Current and future immunosuppressive and immunomodulating therapeutic approaches at the level of antigen presentation and at the lymphocyte and cytokine network levels are discussed.
Karussis
D M
DM
Department of Neurology, Hadassah-Hebrew University Hospital, Jerusalem, Israel.
Abramsky
O
O
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D007167:Immunotherapy; D009103:Multiple Sclerosis / Q000628:therapy*
D000276:Adjuvants, Immunologic