Interleukin-1 receptor antagonist inhibits transient increase of plasma corticosterone in the initial phase of trimethyltin-induced hippocampal necrosis.
The temporal increase of plasma corticosterone (CORT) levels at 3 or 4 days after a single oral administration of trimethyltin (TMT) was suppressed by intracerebroventricular administration of the interleukin-1 receptor antagonist (IL-1ra). On the other hand, glutamate receptor antagonist (MK801) did not affect the TMT-induced CORT level increase. These results indicate that this transient activation of the hypothalamo-pituitary-adrenocortical axis in TMT-treated rats may be in part attributable to the neuroendocrine effects of IL-1 produced by microglia.
Imai
H
H
Regional Environment Division, National Institute for Environmental Studies, Ibaraki, Japan.
Kabuto
M
M
Takita
M
M
Kato
N
N
D000284:Administration, Oral; D000818:Animals; D003345:Corticosterone / Q000037:antagonists & inhibitors* / Q000097:blood*; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012795:Sialoglycoproteins / Q000008:administration & dosage*; D014298:Trimethyltin Compounds / Q000008:administration & dosage / Q000633:toxicity*
D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D014298:Trimethyltin Compounds; D016291:Dizocilpine Maleate; C040533:trimethyltin chloride; D003345:Corticosterone