title: Expression of granulocyte colony-stimulating factor receptor correlates with prognosis in oral and mesopharyngeal carcinoma.
abstract: Granulocyte colony-stimulating factor receptors (G-CSFRs) have been observed on the surface of not only hematopoietic cells but also several cancer cells. The stimulation of G-CSF has been demonstrated to induce proliferation and activation of G-CSFR-positive cells. In this study, we investigated the expression of G-CSFR on the surface of tumor cells and G-CSF production in oral and mesopharyngeal squamous cell carcinoma (SCC) by an immunohistochemical approach. Of 58 oral and mesopharyngeal SCCs, 31 cases (53.4%) and 36 cases (62.1%) were positive for G-CSFR and G-CSF, respectively. There was no association between G-CSFR expression and G-CSF staining. In the group positive for G-CSFR expression, relapse was significantly more likely after primary treatment (P = 0.0069), whereas there was no association between G-CSFR expression and age, sex, tumor size, lymph node metastasis, and clinical stage. Also, the G-CSFR-positive groups had a significantly lower disease-free and overall survival rate than the G-CSFR-negative groups (P = 0.0172 and 0.0188, respectively). However, none of the clinical markers correlated significantly with G-CSF staining, nor did the status of G-CSF production influence the overall survival. The results imply that assessment of G-CSFR may prove valuable in selecting patients with oral and mesopharyngeal SCC for aggressive therapy.
authors.affiliation: Department of Otorhinolaryngology, Fukui Medical University, Yoshida-gun, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsuzuki
authors.forename: S
authors.initials: S
authors.lastname: Fujieda
authors.forename: H
authors.initials: H
authors.lastname: Sunaga
authors.forename: I
authors.initials: I
authors.lastname: Noda
authors.forename: H
authors.initials: H
authors.lastname: Saito
mesh_terms: D000368:Aged; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism*; D010610:Pharyngeal Neoplasms / Q000378:metabolism*; D011379:Prognosis; D016184:Receptors, Colony-Stimulating Factor / Q000378:metabolism*
chemical_list: D016184:Receptors, Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor