title: Cancer risk after adjuvant chemo- or chemohormonal therapy of breast cancer.
abstract: This study is based on 194 patients with primary breast cancer treated with adjuvant CNF combination chemotherapy, who were followed-up for the risk of subsequent neoplasms. During an average follow-up of 4.8 years, 16 cases of new cancers were detected. Nine non-breast cancers were observed versus 2.2 expected (standardized incidence ratio 4.2). Of the patients with subsequent malignancies, 88% had received antiestrogen (chemohormonal adjuvant therapy); the percentage among all patients was 25%. We conclude that the benefit derived from adjuvant therapy of breast cancer may be reduced because of an increased risk of subsequent cancers.
authors.affiliation: Department of Oncology, Kuopio University Hospital, Finland.
authors.forename: E J
authors.initials: EJ
authors.lastname: Kumpulainen
authors.forename: P P
authors.initials: PP
authors.lastname: Hirvikoski
authors.forename: E
authors.initials: E
authors.lastname: Pukkala
authors.forename: R T
authors.initials: RT
authors.lastname: Johansson
mesh_terms: D000328:Adult; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D008942:Mitoxantrone / Q000009:adverse effects / Q000627:therapeutic use; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D012306:Risk
chemical_list: D018931:Antineoplastic Agents, Hormonal; D003520:Cyclophosphamide; D008942:Mitoxantrone; D005472:Fluorouracil