A nosocomial cluster of Candida inconspicua infections in patients with hematological malignancies.
Candida inconspicua was recovered from three patients with hematological malignancies. Two patients had intravenous-catheter-associated fungemia, whereas the third had fungal hepatitis. The three cases of infection occurred over a period of 1 month in patients staying in adjacent single rooms. In vitro susceptibility testing of fungal strains showed all isolates to be resistant to fluconazole, with MICs greater than 32 microg/ml. All of the strains had identical DNA restriction profiles and randomly amplified polymorphic DNA fingerprints. These data suggest a nosocomially acquired infection emanating from a common source within the hospital environment.
D'Antonio
D
D
Dipartimento di Ematologia ed Oncologia, Ospedale Santo Spirito, Pescara, Italy.
Violante
B
B
Mazzoni
A
A
Bonfini
T
T
Capuani
M A
MA
D'Aloia
F
F
Iacone
A
A
Schioppa
F
F
Romano
F
F
D000328:Adult; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D016000:Cluster Analysis; D003428:Cross Infection / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D004196:Disease Outbreaks; D005260:Female; D016469:Fungemia / Q000382:microbiology; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D008224:Lymphoma, Follicular / Q000150:complications; D008297:Male; D008875:Middle Aged