[The effect of MS-551 on two VT/Vf patients in CABG: a case report].
Uncontrollable arrhythmia is one of the causes of operative death in CABG. We report two cases of successful treatment of recurrent VT/Vf in CABG operation by MS-551. One case was a 72-year-old male, who had unstable angina and OMI with left ventricular dysfunction (LVEF 24%). After weaning from CPB, the rhythm turned into VT/Vf suddenly. Lidocaine and verapamil were not effective. VT/Vf recurred over the over. The another case was a 52-year-old male, who had OMI and effort angina. He became myocardial infarction during operation. VT/Vf occurred after the weaning from CPB. Lidocaine and amiodarone were of no effect on his VT/Vf. In both cases, intravenous injection of MS-551 promptly stopped VT/Vf. Use of MS-551 was limited mainly on DCM patients. But other antiarrhythmic agents were ineffective on these cases. We have had to continue support circulation for a long time without MS-551. As MS-551 is being used as a trial on medically followed patients, it was unknown how effective clinically on the acute myocardial infarction. In this regard, our cases may suggest a positive answer to that.
Uwabe
K
K
Department of Cardiovascular Surgery and Cardiology, Heart Institute of Japan, Tokyo Women's Medical College, Japan.
Endo
M
M
Nishida
H
H
Tomizawa
Y
Y
Koyanagi
H
H
Ohnishi
S
S
Kasanuki
H
H
D000368:Aged; D000789:Angina, Unstable / Q000601:surgery*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D011744:Pyrimidinones / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D011744:Pyrimidinones; C076259:nifekalant