Distinct light microscopic changes in human immunodeficiency virus-associated nemaline myopathy.
The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM; however, HAONM had distinctive pathologic features by light microscopy. The fibers in HAONM showed marked intrasarcoplasmic changes, including small vacuoles and granular degeneration.
Feinberg
D M
DM
Department of Neurology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA.
Spiro
A J
AJ
Weidenheim
K M
KM
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D019992:Databases as Topic; D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology*; D017696:Myopathies, Nemaline / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology