title: Effect of systemic pretreatment with betamethasone on the bacterial flora, inflammatory response, and polyp formation in experimentally infected rabbit maxillary sinus mucosa.
abstract: To investigate possible effects of corticosteroids on polyp formation and local bacterial colonization, pneumococcal sinusitis was experimentally induced in rabbits pretreated with betamethasone or saline. After 7 days, macroscopic polyps were counted post-mortem and on histologic slides after serial sectioning. Histologic sections were also examined with light microscopy. Macroscopic polyps were significantly fewer in animals given betamethasone, while there was no difference regarding the number of microscopic polyps. Ingrowth of pathogenic microorganisms was found in five of eight rabbits given placebo but in none of the animals treated with corticosteroids (P < 0.05). The reduced number of pathogenic strains in these animals may be explained by a better-preserved local host defense. The lower number of macroscopic polyps in the same animals could be because of a delayed mucosal repair and subsequent polyp formation.
authors.affiliation: Department of Otorhinolaryngology, Huddinge University Hospital, Karolinska Institute, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Norlander
authors.forename: S H
authors.initials: SH
authors.lastname: Kwon
authors.forename: G
authors.initials: G
authors.lastname: Henriksson
authors.forename: K M
authors.initials: KM
authors.lastname: Westrin
authors.forename: K
authors.initials: K
authors.lastname: Sandstedt
authors.forename: P
authors.initials: P
authors.lastname: Stierna
mesh_terms: D000818:Animals; D001623:Betamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008443:Maxillary Sinus / Q000382:microbiology; D008444:Maxillary Sinus Neoplasms / Q000473:pathology / Q000517:prevention & control*; D015523:Maxillary Sinusitis / Q000382:microbiology / Q000473:pathology; D009092:Mucous Membrane / Q000382:microbiology / Q000473:pathology; D011127:Polyps / Q000473:pathology / Q000517:prevention & control*; D011292:Premedication; D011817:Rabbits; D013296:Streptococcus pneumoniae
chemical_list: D005938:Glucocorticoids; D001623:Betamethasone