Prospects for human papillomavirus vaccine development: emerging HPV vaccines.
This review concentrates on recent advances in human papillomavirus vaccine development. Strategies for prophylactic HPV subunit vaccines utilizing recombinantly synthesized, immunogenic virus-like particles are discussed. Therapeutic strategies focusing on the induction of cell-mediated immunity and gene manipulation for the treatment of established HPV-associated disease are also reviewed.
Hines
J F
JF
Department of Obstetrics and Gynecology, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200, USA. hinesjeff@aol.com
Ghim
S J
SJ
Jenson
A B
AB
D004341:Drug Evaluation; D005260:Female; D015316:Genetic Therapy; D006801:Humans; D016233:Immunotherapy, Active; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D030361:Papillomavirus Infections / Q000517:prevention & control / Q000821:virology; D053918:Papillomavirus Vaccines; D014412:Tumor Virus Infections / Q000517:prevention & control / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control / Q000821:virology; D014614:Vaccines, Synthetic / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage
D053918:Papillomavirus Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines