Mycobacterium tuberculosis and the complement system.
Accumulated evidence to date confirms the importance of the C3-CR pathway in the phagocytosis of pathogenic mycobacteria. Detailed receptor-ligand studies for phagocytosis are creating the framework to test the hypothesis that the entry pathway for these bacteria influences the immediate host cell response and their intracellular fate. These types of study are particularly important for improving our understanding of the outcome of primary infection in humans, where the number of bacilli is presumed to be very low.
Schlesinger
L S
LS
Dept of Medicine, University of Iowa, Iowa City 52242, USA. larry-schlesinger@uiowa.edu
D003167:Complement Activation; D003175:Complement C2 / Q000276:immunology; D050678:Complement C2a; D003176:Complement C3 / Q000276:immunology; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D007963:Leukocytes, Mononuclear / Q000276:immunology; D018448:Models, Immunological; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D009895:Opsonin Proteins; D010587:Phagocytosis; D011951:Receptors, Complement
D003175:Complement C2; D003176:Complement C3; D009895:Opsonin Proteins; D011951:Receptors, Complement; D050678:Complement C2a