title: Proliferating cells in adult cardiomyopathic hamster ventricles.
abstract: Myocardium of hereditary hypertrophic cardiomyopathic hamsters UM.X7.1 between 60 and 90 days of life shows large clusters of densely packed, actively proliferating cells with a rhabdoid appearance. Immunohistochemical studies showed that most of proliferating cells express, although with variable patterns, muscular markers such as desmin, alpha-sarcomeric actin, myoglobin and alpha/gamma-smooth muscle actin. The simultaneous occurrence of a poorly differentiated appearance, intense proliferating activity and expression of muscular markers seems to indicate that cluster cells may be muscular in origin and that their proliferation can be a fundamental pathophysiological step in the onset of cardiomyopathy. The possibility that myocardial proliferating cells originated from de-differentiated adult cardiomyocytes, which undergo a short cellular proliferation program, or from not fully matured (fetal) cardiomyocytes scattered throughout the myocardium is discussed.
authors.affiliation: Department of Internal Medicine, University of Rome, Tor Vergata, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Carbone
authors.forename: M
authors.initials: M
authors.lastname: Minieri
authors.forename: P
authors.initials: P
authors.lastname: Di Nardo
mesh_terms: D000818:Animals; D002312:Cardiomyopathy, Hypertrophic / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D006224:Cricetinae; D007150:Immunohistochemistry; D009124:Muscle Proteins / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism / Q000473:pathology
chemical_list: D009124:Muscle Proteins