Basic science and clinical aspects of wound healing in glaucoma filtering surgery.
Success of glaucoma filtration surgery is influenced by the wound healing response. Attention has been focused on pharmacological agents to control a process that leads to excessive scarring and eventual failure of glaucoma filtration surgery. Several agents, including 5-fluorouracil and mitomycin C, as well as other antiproliferative drugs will be discussed. Newer antifibrotic agents and novel drug delivery systems are under development in tissue culture and animal models in an effort to improve efficacy and safety. This article summarizes current treatment modalities and future prospects to prevent excessive wound healing and improve the success of glaucoma filtration surgery.
Chang
M R
MR
Jules Stein Eye Institute, Department of Opthalmology, UCLA School of Medicine, Los Angeles, California 90095-7004, USA.
Cheng
Q
Q
Lee
D A
DA
D046508:Culture Techniques; D005347:Fibroblasts / Q000187:drug effects; D005355:Fibrosis / Q000517:prevention & control; D018463:Filtering Surgery / Q000009:adverse effects*; D005472:Fluorouracil / Q000494:pharmacology; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D016685:Mitomycin / Q000494:pharmacology; D016032:Randomized Controlled Trials as Topic; D014945:Wound Healing / Q000187:drug effects*
D016685:Mitomycin; D005472:Fluorouracil