The distribution of estrogen receptors in the brainstem of female sheep.
Estrogen receptors (ER) have been mapped in the brainstem of the female sheep with immunocytochemistry. A small group of ER-positive cells was found in the lateral and ventrolateral medulla and a larger number in the nucleus of the solitary tract. ER-positive cells were abundant in the area postrema. In the rostral brainstem a small number of ER-positive cells were found in the lateral and dorsal regions of the periaqueductal gray area, and some immediately lateral to the fourth ventricle. Many ER-positive cells were also present in the region around the superior cerebellar peduncle, particularly in the lateral parabrachial nucleus. These results describe for the first time the distribution of ER in the brainstem of the sheep and indicate that the majority of estrogen-containing cells are located in structures involved in the regulation of cardiovascular parameters and fluid balance.
Scott
C J
CJ
Department of Physiology, Monash University, Clayton, Victoria, Australia. chris.scott@med.monash.edu.au
Rawson
J A
JA
Pereira
A M
AM
Clarke
I J
IJ
D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D001933:Brain Stem / Q000378:metabolism*; D005260:Female; D008526:Medulla Oblongata / Q000378:metabolism; D009928:Organ Specificity; D011960:Receptors, Estrogen / Q000378:metabolism*; D012756:Sheep
D011960:Receptors, Estrogen