Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3.
Nasopharyngeal carcinoma is a malignancy that is prevalent among populations from Southeast Asia. Epidemiological studies indicate that genetic predisposition, Epstein-Barr virus, and environmental conditions may play a role in determining incidence. Molecular studies have implicated a tumor suppressor gene(s) on the short arm of chromosome 3. In this study we provide functional evidence, via monochromosome transfer, for a tumor suppressor gene(s) activity in chromosome 3p21.3.
Cheng
Y
Y
University of California, Irvine, Irvine, CA 92697-4025, USA.
Poulos
N E
NE
Lung
M L
ML
Hampton
G
G
Ou
B
B
Lerman
M I
MI
Stanbridge
E J
EJ
D000818:Animals; D002277:Carcinoma / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008819:Mice, Nude; D018895:Microsatellite Repeats; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured