Complementary DNA (cDNA) sequence of baboon tumor necrosis factor alpha.
Baboons are less LPS-sensitive than humans, even though their immune response mechanisms are similar. Since TNFalpha is a central mediator of the LPS-response we cloned and sequenced the baboon TNFalpha cDNA and compared the resulting sequence with the human TNFalpha sequence. Analysis of the TNFalpha protein coding region indicated 97% homology and of the 3' UTF 89%. The predicted baboon TNFalpha amino acid sequence differed at 10 positions from the human sequence. "TA" rich motifs within the 3' UTR were 100% homologous.
Haudek
S B
SB
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063, USA.
Redl
H
H
Schlag
G
G
Giroir
B P
BP
D000595:Amino Acid Sequence; D000818:Animals; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D010215:Papio; D017386:Sequence Homology, Amino Acid; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D018076:DNA, Complementary; D014409:Tumor Necrosis Factor-alpha