[Bone mineralization in insulin-dependent diabetes mellitus].
One of insulin-dependent diabetes mellitus (IDDM) complications are bone mineral disorders called diabetic osteopathy. Because of many controversies of this subject we took a research of bone mineralisation in IDDM patients before 40 years old. The evaluation of BMD was performed with the use of X-ray dual energy absorptiometry--DEXA in the AP projection for lumbar part of vertebral column (BMD L2-L4), left femur neck (BMD-neck) and total skeleton (BMD-total). Bone tissue metabolism was evaluated with the aid of biochemical tests. The examined group consisted of 99 patients with IDDM (45 women and 54 men), without any other risk factors for changes in bone metabolism. The results were related to: sex, age in which IDDM was diagnosed, duration of IDDM, metabolic control of diabetes and to some IDDM complications. The control group consisted of 113 healthy subjects matched for age, sex, weight, height and calcium diet. We observed that BMD in IDDM patients before 40 years old was significantly lower than in healthy subject. One of some diabetic osteopathy pathomechanism seems to be an advantage of bone resorption over bone formation. Bone demineralisation which was observed to be most pronounced in femur neck, was not related to age, differed in accordance to sex and was higher of age when IDDM appeared was lower. BMD was also related to duration of IDDM and metabolic control of IDDM.
Goliat
E
E
Kliniki Chorób Wewnetrznych Akademii Medycznej w Warszawie.
Lipińska
A
A
Marusza
W
W
Ostrowski
K
K
D015502:Absorptiometry, Photon; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001862:Bone Resorption / Q000503:physiopathology*; D001842:Bone and Bones / Q000378:metabolism*; D002113:Calcification, Physiologic; D002118:Calcium / Q000097:blood / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D005272:Femur Neck / Q000378:metabolism; D006801:Humans; D006909:Hydroxyproline / Q000097:blood; D008159:Lumbar Vertebrae / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000097:blood / Q000652:urine
D010710:Phosphates; D000469:Alkaline Phosphatase; D006909:Hydroxyproline; D002118:Calcium
Mineralizacja tkanki kostnej w cukrzycy insulinozaleznej.