[Participation of N-methyl-D-aspartate receptors in modification of the frequency composition in rat electroencephalogram].
Injection of N-methyl-D-aspartate (NMDA) into the brain of nonanesthetized and nonimmobilized rats with chronically implanted electrodes in the brain cortex and cannula in its lateral ventricle caused dose-dependent augmentation of low-frequency (0.5-2.5 Hz) and diminution of high-frequency (9-20 Hz) components of the ECG spectrum. The specific antagonist of nmm the NMDA-subtype glutamate/aspartate receptors CPP removed the effects on EEG of subsequent NMDA administration. The results of experiments with D- and L-glutamate are indicative of the receptor character of the NMDA effects of intensification of the slow EEG rhythm related to the appearance of seizure activity in the brain.
Vorob'ev
V V
VV
Institute of Cell Biophysics, Russian Academy of Sciences, Moscow Region, Russia.
Akhmetova
E R
ER
Kovalev
G I
GI
D000818:Animals; D004569:Electroencephalography; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D013237:Stereoisomerism
D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D010879:Piperazines; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C104291:3-(2-carboxypiperazine-4-yl)propyl-1-phosphate; D018698:Glutamic Acid; D016202:N-Methylaspartate
Uchastie retseptorov N-metyl-D-aspartata v modifikatsii chastotnogo sostava élektroéntsefalogrammy krys.