[Population features of gene mutation frequency of the CKR-5 receptor, determining sensitivity to the AIDS virus].
Recently, it was shown that a 32-bp deletion in the CKR5 macrophage chemokine receptor gene produced resistance to HIV infection. Frequencies of the CKR5 mutant allele in Russians, Tatars, Uzbeks, Kazakhs, Azerbaijanis, Uigurts, Tuvinians, and Georgians estimated by means of the PCR technique were equal to 0.13, 0.12, 0.85, 0.06, 0.05, 0.04, 0.03, and 0.00, respectively. While the theoretically expected frequency of deletion homozygotes in Russians and Tatars was 1.7%, none of such homozygotes were detected among the 90 persons examined. The data suggested that about 25% of the population in northwestern Russia is highly resistant to HIV infection.
Aseev
M V
MV
Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg, Russia.
Shawi
A
A
Dean
M
M
Baranov
V S
VS
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015497:HIV-1 / Q000378:metabolism*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction; D019713:Receptors, CCR5 / Q000235:genetics*; D017384:Sequence Deletion
D019713:Receptors, CCR5
Populiatsionnye osobennosti chastot mutatsii gena khemokinovogo retseptora CKR-5, opredeliaiushchego chuvstvitel'nost' k virusu SPIDa.