title: Ultrasound-guided fine-needle aspiration cytology of nonpalpable breast lesions: Institut Curie's experience with 198 histologically correlated cases.
abstract: BACKGROUND
  The value of ultrasound-guided fine-needle aspiration cytology (FNAC) in the diagnosis of nonpalpable breast lesions remains a subject of debate. To determine the accuracy of this procedure in these lesions, a comparative analysis with open surgical biopsy in 188 patients was performed.
  
  
  METHODS
  Six hundred and fifty-four nonpalpable breast lesions detected by ultrasound in 585 patients were subjected to FNAC. Of these, 198 lesions (30.3%) from 188 patients were surgically excised.
  
  
  RESULTS
  Histologically, 105 lesions (53%) were malignant and 93 (47%) were benign. Among carcinomas, 65 cases (61.9%) were concordant, whereas 21 cases (20%) were suspicious, 12 cases (11.4%) were false-negative (benign), and 7 cases (6.7%) were unsatisfactory for diagnosis. Among benign lesions, 80 cases (86%) were concordant, whereas 5 cases (5.4%) were suspicious, and 8 cases (8.6%) were unsatisfactory. No false-positive diagnoses were made. The sensitivity of the FNAC method was 87.8%, the specificity was 94.5%, and the positive predictive value was 94.6%.
  
  
  CONCLUSIONS
  These results indicate that, with the exception of random microcalcified lesions, ultrasound-guided FNAC is a valuable and reliable technique in the diagnosis of nonpalpable breast lesions.
authors.affiliation: Département de Pathologie, Institut Curie, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Klijanienko
authors.forename: J F
authors.initials: JF
authors.lastname: Côté
authors.forename: F
authors.initials: F
authors.lastname: Thibault
authors.forename: B
authors.initials: B
authors.lastname: Zafrani
authors.forename: M
authors.initials: M
authors.lastname: Meunier
authors.forename: K
authors.initials: K
authors.lastname: Clough
authors.forename: B
authors.initials: B
authors.lastname: Asselain
authors.forename: P
authors.initials: P
authors.lastname: Vielh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods; D001940:Breast / Q000033:anatomy & histology; D001941:Breast Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D016217:Ultrasonography, Mammary