Vitamin K1-induced localized scleroderma (morphea) with linear deposition of IgA in the basement membrane zone.
We describe a 45-year-old white man in whom distinctive clinical and histologic features of localized scleroderma developed at sites of injection of vitamin K1 (phytonadione). A direct immunofluorescence test demonstrated prominent linear deposition of IgA along the basement membrane zone. No circulating antibasement membrane zone IgA antibodies were identified on indirect immunofluorescence testing. We believe that the unusual immunofluorescence finding in our patient is nonspecific and represents an epiphenomenon caused by cutaneous injury.
Alonso-Llamazares
J
J
Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
Ahmed
I
I
D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001485:Basement Membrane / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D019085:Fluorescent Antibody Technique, Direct; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007020:Hypoprothrombinemias / Q000150:complications / Q000188:drug therapy; D007070:Immunoglobulin A / Q000187:drug effects* / Q000378:metabolism; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000009:adverse effects*
D000933:Antifibrinolytic Agents; D007070:Immunoglobulin A; D010837:Vitamin K 1