Tyrosine phosphorylation in the action of neuropeptides and growth factors.
The non-receptor tyrosine kinase p125FAK and the adaptor proteins paxillin and p130CAS are implicated in signal transduction at the focal adhesion plaques. An increase in the tyrosine phosphorylation of p125FAK, paxillin and p130CAS has been identified as an early signal in response to integrin engagement, mitogenic neuropeptides, bioactive lipids and growth factors. Agonist-mediated induction of tyrosine phosphorylation of focal adhesion proteins occurs through a PKC and Ca(2+)-independent pathway that is critically dependent on the integrity of the actin cytoskeleton and on functional Rho. The coordinate tyrosine phosphorylation of p125FAK, paxillin and p130CAS plays a role in cell locomotion, DNA synthesis and apoptosis.
Rozengurt
E
E
Growth Regulation Laboratory, Imperial Cancer Research Fund, London, U.K.
Rodríguez-Fernández
J L
JL
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002455:Cell Division; D050719:Crk-Associated Substrate Protein; D003598:Cytoskeletal Proteins / Q000378:metabolism; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D008246:Lysophospholipids / Q000494:pharmacology; D009479:Neuropeptides / Q000378:metabolism* / Q000494:pharmacology; D051419:Paxillin; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D010982:Platelet-Derived Growth Factor / Q000378:metabolism / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011506:Proteins; D050717:Retinoblastoma-Like Protein p130; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D014443:Tyrosine / Q000378:metabolism*
C493841:BCAR1 protein, human; D015815:Cell Adhesion Molecules; D050719:Crk-Associated Substrate Protein; D003598:Cytoskeletal Proteins; D006133:Growth Substances; D008246:Lysophospholipids; D009479:Neuropeptides; C496061:PXN protein, human; D051419:Paxillin; D010750:Phosphoproteins; D010982:Platelet-Derived Growth Factor; D011506:Proteins; D050717:Retinoblastoma-Like Protein p130; C005356:sphingosine phosphorylcholine; D010767:Phosphorylcholine; D014443:Tyrosine; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human; D013110:Sphingosine