title: Muscle regionalization.
abstract: In this review, the term muscle fibre regionalization signifies the presence of regional intramuscular differences in fibre type composition. As is well known, highly regionalized muscles commonly have greater concentrations of slow fibres deep than superficially. However, the degree of regionalization varies markedly between muscles and is not confined to deep vs. superficial locations. Fibres of the same myosin type may show regionalized differences in their metabolic enzyme activity, even within single motor units (Larsson, 1992). Regionalization of fibre type composition occurs also within single neuromuscular partitions. The intraspinal position of motoneurones is often coarsely related to the intramuscular sites of their muscle units. Muscles with a marked fibre type regionalization tend to show a corresponding regionalization of activity; in several muscles, however, the activity regionalization may vary depending on the motor task. During early development, fibre type regionalization emerges even under aneural conditions. The mechanisms are still unknown; relevant aspects of early development are briefly reviewed.
authors.affiliation: Department of Medical Physiology, University of Groningen, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Kernell
mesh_terms: D000818:Animals; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000166:cytology* / Q000201:enzymology