[Efficacy of immunosorption in patients with systemic lupus erythematosus: double blind controlled trial].
Efficacy of immunosorption (IS) employing perfusion of whole blood through activated charcoal containing DNA was studied in 11 patients with systemic lupus erythematosus (SLE). 11 SLE patients exposed to hemosorption on charcoal free from DNA served as controls. When used in combination with intensive therapy (corticosteroids and cytostatic immunosuppressant), IS produced a positive effect on lupus nephritis symptoms in 8 out of 10 patients with kidney affection. AntiDNA antibodies blood level decreased by 53.6% after two IS procedures, while only by 36.4% after nonselective hemosorption. Reduced count and functional activity of B-cells recorded after IS contribute much to final outcome of the treatment.
Amosova
E N
EN
Iaremenko
O B
OB
Snezhkova
E A
EA
Drannik
G V
GV
D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology; D034961:Antigens, Nuclear; D001402:B-Lymphocytes / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006464:Hemoperfusion; D006801:Humans; D007164:Immunosorbents / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology / Q000628:therapy*; D008297:Male; D009687:Nuclear Proteins / Q000276:immunology; D016896:Treatment Outcome
D000974:Antibodies, Antinuclear; D034961:Antigens, Nuclear; D015415:Biomarkers; D005938:Glucocorticoids; D007164:Immunosorbents; D007166:Immunosuppressive Agents; D009687:Nuclear Proteins
Effektivnost' immunosorbtsii u bol'nykh sistemnoĭ krasnoĭ volchankoĭ: dvoĭnoe slepoe kontroliruemoe issledovanie.