title: Tetrodotoxin inactivation of the gustatory cortex disrupts the effect of the N-methyl-D-aspartate antagonist ketamine on latent inhibition of conditioned taste aversion in rats.
abstract: The effect of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist ketamine on latent inhibition of taste aversion learning was studied in rats. Systemic injections of ketamine (50 mg/kg) applied after each of three preexposures to sodium saccharin (0.1%) disrupted the latent inhibition effect. The blockade was not due to aversive properties of ketamine, because three saccharin-ketamine pairings did not produce saccharin aversion. Moreover, the ketamine-induced blockade of latent inhibition was disrupted by tetrodotoxin injections (10 ng/microl)-induced reversible inactivation of gustatory cortex, applied after each preexposure. A specific gustatory cortex mediation of the ketamine effect is discussed.
authors.affiliation: Department of Experimental Psychology and Physiology of Behavior, University of Granada, Campus Cartuja, Spain. mgallo@platon.ugr.es
authors.forename: M
authors.initials: M
authors.lastname: Gallo
authors.forename: E
authors.initials: E
authors.lastname: Bielavska
authors.forename: G
authors.initials: G
authors.lastname: Roldán
authors.forename: J
authors.initials: J
authors.lastname: Bures
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003213:Conditioning, Psychological / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D007649:Ketamine / Q000008:administration & dosage*; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects*; D013779:Tetrodotoxin / Q000008:administration & dosage*
chemical_list: D013779:Tetrodotoxin; D016202:N-Methylaspartate; D007649:Ketamine