Chromatographic analysis (TLC) of fluoxetine, doxepine, imipramine and opipramol in human plasma.
Fluoxetine, imipramine, doxepine and opipramol after liquid-liquid extraction were separated by TLC on silica gel 60 GF254 by ascending and horizontal technique using suitable mobile phases. The substances were identified by UV irradiation at 254 nm and by spraying of Amelinka's reagnet (up to the amount 0.25 microgram fluoxetine and 0.05 microgram imipramine, doxepine and opipramol).
Misztal
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Department of Medicinal Chemistry, School of Medicine, Lublin, Poland.
Hopkała
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H
Sławik
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D000928:Antidepressive Agents / Q000097:blood*; D002855:Chromatography, Thin Layer / Q000379:methods*; D004316:Doxepin / Q000097:blood; D005473:Fluoxetine / Q000097:blood; D006801:Humans; D007099:Imipramine / Q000097:blood; D009888:Opipramol / Q000097:blood; D013056:Spectrophotometry, Ultraviolet
D000928:Antidepressive Agents; D005473:Fluoxetine; D004316:Doxepin; D009888:Opipramol; D007099:Imipramine