title: Antiplasmodial activity of mono- and dimeric carbazoles.
abstract: A series of mono- and dimeric natural and structurally modified carbazoles has been tested for activity against Plasmodium falciparum. One of the monomers, the synthetic compound 1,4-diacetoxy-3-methylcarbazole (17), displays the highest activity, with an IC50 value of 1.79 micrograms/ml. It is distinctly more active than the as yet best natural compound, 1-hydroxy-3-methylcarbazole (4) (4).
authors.affiliation: Institut für Organische Chemie der Universität, Würzburg, Germany. bringman@chemic.uni-wuerzburg.de
authors.forename: G
authors.initials: G
authors.lastname: Bringmann
authors.forename: A
authors.initials: A
authors.lastname: Ledermann
authors.forename: J
authors.initials: J
authors.lastname: Holenz
authors.forename: M T
authors.initials: MT
authors.lastname: Kao
authors.forename: U
authors.initials: U
authors.lastname: Busse
authors.forename: H G
authors.initials: HG
authors.lastname: Wu
authors.forename: G
authors.initials: G
authors.lastname: François
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*; D013057:Spectrum Analysis
chemical_list: D000962:Antimalarials; D002227:Carbazoles