title: A case report of biliary cystadenoma and cystadenocarcinoma.
abstract: Three cases of intrahepatic biliary cystadenoma with mesenchymal stroma and one case of biliary cystadenocarcinoma are presented. Their immunohistochemical features and the surgical treatment are discussed together with a brief review of the literature. The benign cystadenomas stained positive for cytokeratin and CA 19-9 in the epithelium of the cyst wall. Mesenchymal stromal cells were strongly positive for a-SMA and moderately positive for desmin. The epithelium of the cystadenocarcinoma, however, was positive only for cytokeratin and the stroma only for a-SMA. Our findings indicate that biliary cystadenomas seem to be of primitive hepatobiliary origin. Furthermore, the malignant variant cystadenocarcinoma may loose its immunoreactivity for CA 19-9 and desmin.
authors.affiliation: Helsinki University Central Hospital, Department of Surgery.
authors.forename: J
authors.initials: J
authors.lastname: Sirén
authors.forename: P
authors.initials: P
authors.lastname: Kärkkäinen
authors.forename: P
authors.initials: P
authors.lastname: Luukkonen
authors.forename: T
authors.initials: T
authors.lastname: Kiviluoto
authors.forename: E
authors.initials: E
authors.lastname: Kivilaakso
mesh_terms: D002759:Adenoma, Bile Duct / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D000328:Adult; D001650:Bile Duct Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D003536:Cystadenocarcinoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D003537:Cystadenoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged