Pretreatment plasma HVA predicts neuroleptic response in manic psychosis.
Elevated pretreatment plasma free homovanillic acid (HVA) predicted acute response to neuroleptic treatment in patients with manic psychosis. These findings suggest that plasma HVA may be a useful predictor of a successful short-term response in manic as well as schizophrenic psychoses, and that elevated pre-synaptic dopaminergic release may play a role in more than one group of psychotic disorders.
Mazure
C M
CM
Yale University School of Medicine, Department of Psychiatry, Yale New Haven Hospital, CT 06504, USA.
Bowers
M B
MB
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006220:Haloperidol / Q000494:pharmacology* / Q000627:therapeutic use*; D006719:Homovanillic Acid / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D008875:Middle Aged; D010546:Perphenazine / Q000494:pharmacology* / Q000627:therapeutic use*; D011379:Prognosis
D014150:Antipsychotic Agents; D008734:Methoxyhydroxyphenylglycol; D010546:Perphenazine; D006220:Haloperidol; D006719:Homovanillic Acid