[Plaque morphology after arterial interventions in the New Zealand white rabbit--which model of restenosis is most suitable?].
OBJECTIVE
For evaluation of therapy for possible reduction of restenosis after PTA a suitable animal model is needed. The influence of different interventions on arterial plaque composition was analysed in New Zealand White Rabbits.


METHODS
The following interventions were performed in the infrarenal aorta of New Zealand White Rabbits (n = 42): a) Balloon denudation (BD) with and b) without 0.5% cholesterol diet (CD), c) application of a Wiktor stent, d) CF without BD, and e) control group, 6 weeks after intervention morphometry and histology were performed.


RESULTS
After BD the stenosis rate measured 26 +/- 18%, additional CD after prior BD increased the stenoses rate by 2.5 times up to 61.1%. After stent implantation there was only a thin neointimal layer (89 +/- 68 microns) around the stent wires.


CONCLUSIONS
Neither implantation of stents nor single CD are suitable as restenosis models. BD with and without CD was followed by a distinct neointima formation with different cellular composition. The New Zealand White Rabbit constitutes an acceptable model for contemporary research in arteriosclerosis.
Tepe
G
G
Abteilung für Radiologische Diagnostik, Universität Tübingen.
Duda
S H
SH
Hagmeier
S
S
Brehme
U
U
Kalinowski
M
M
Bruck
B
B
Schmahl
F W
FW
Claussen
C D
CD
D000800:Angioplasty, Balloon; D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology*; D001161:Arteriosclerosis / Q000473:pathology* / Q000628:therapy*; D002791:Cholesterol, Dietary; D004036:Diet, Atherogenic; D008297:Male; D011817:Rabbits; D012008:Recurrence; D015607:Stents; D017539:Tunica Intima / Q000473:pathology
D002791:Cholesterol, Dietary
Plaquemorphologie nach arteriellen Interventionen am Weissen Neuseelandkaninchen--Wann ist welches Restenosemodell geeignet?