[Various aspects of increased resistance of the brain tissue and its vessels to extreme effects with the use of GABAergic compounds and Ca(2+) antagonists].
Experiments on rats showed that the morpho-functional state of the cerebral cortex microcirculatory bed suffers marked changes in different periods of hypokinesia. This was accompanied with obvious morphological changes in the brain, the development of brain edema in particular. It was found that the GABAergic agents which we used ranked below Ca-antagonists in antiedemic activity.
Akopian
V P
VP
Erevan State Medical University, Armenia.
Melkonian
K V
KV
Samvelian
V M
VM
Shirinian
E A
EA
Mirzoian
N R
NR
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D001929:Brain Edema / Q000517:prevention & control; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004146:Dioxanes / Q000494:pharmacology; D005260:Female; D018682:GABA Agents / Q000494:pharmacology*; D018756:GABA Antagonists / Q000494:pharmacology; D058787:GABA-A Receptor Antagonists; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013844:Thiazoles / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D002121:Calcium Channel Blockers; D004146:Dioxanes; D018682:GABA Agents; D018756:GABA Antagonists; D058787:GABA-A Receptor Antagonists; D013844:Thiazoles; C107649:beditine; D005680:gamma-Aminobutyric Acid; D014700:Verapamil; D009543:Nifedipine; D001640:Bicuculline; D010889:Piracetam
Nekotorye aspekty povysheniia rezistentnosti mozgovoĭ tkani i ee sosudov k ékstremal'nym vozdeĭstviiam s pomoshch'iu GAMK-ergicheskikh veshchestv i antagonistov Ca(++).