[The possible role of plasma membranes receptor domains in the mechanisms of cell differentiation and proliferation, and the control over these processes by specific receptor ligands].
Within the limits of the previously proposed conception concerning the dynamic domain organization of receptor molecules in biological membranes the possible role of receptor domains of plasma membranes in the mechanisms of cell differentiation and division, and also the control over these processes by specific receptor ligands is discussed. It is suggested that receptor domains of plasma membranes take part in secretion growth factor and chalones by cells, and two possible mechanisms of such secretion are proposed. The conclusion that degree of cell differentiation can be determined by dimensions of receptor domains which are formed on the cell plasma membrane ia made. It is suggested that phosphatidylinositol and cyclic nucleotide metabolisms may be coupled to biochemical control over cell differentiation and division by specific receptor ligands. Molecular mechanisms of such control are also discussed. The theoretical substantiation of the existence of two types of growth factors, competence and progression, and also the existence of polyfunctional proliferation regulators is given. A new interpretation of the cell cycle is proposed. Kinetic diagram of alteration of number of cells in cell population is examined. The origin of aging of cell cultures and tissues, and also the origin of cell immortalization are postulated.
Talako
S A
SA
Laboratory of Molecular Bases of Reception, Mogilev, Belorussia.
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D008024:Ligands; D011956:Receptors, Cell Surface
Vozmozhnaia rol' retseptornykh domenov plazmaticheskikh membran v mekhanizmakh differentsirovki i deleniia kletok i reguliatsii etikh protsessov spetsificheskimi retseptornymi ligandami.