Loss of serotonin-containing neurons in the raphe of patients with myotonic dystrophy: a quantitative immunohistochemical study and relation to hypersomnia.
Hypersomnia occurs frequently in patients with myotonic dystrophy (MyD). We performed a quantitative immunohistochemical study of serotonin (5-HT)-containing neurons linked to hypersomnia in the dorsal raphe nucleus (DRN) and the superior central nucleus (SCN) in 8 patients with MyD, 5 of whom showed hypersomnia, and in 12 age-matched controls. The densities of 5-HT neurons in the DRN and the SCN were significantly lower in MyD patients with hypersomnia than in MyD patients without hypersomnia and controls. These data suggest that the loss of 5-HT neurons of the DRN and the SCN is associated with the presence of hypersomnia in MyD.
Ono
S
S
Department of Neurology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan.
Takahashi
K
K
Jinnai
K
K
Kanda
F
F
Fukuoka
Y
Y
Kurisaki
H
H
Mitake
S
S
Inagaki
T
T
Yamano
T
T
Nagao
K
K
D000368:Aged; D006970:Disorders of Excessive Somnolence / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000150:complications* / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D011903:Raphe Nuclei / Q000473:pathology*; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin