Immunoadjuvant effect of inactivated Cryptococcus neoformans.
Cryptococcus neoformans disseminated into the central nervous system (CNS) of intraperitoneally inoculated adult ICR mice, but did not potentiate penetration of concurrently given Bhanja virus (Bunyaviridae) into the CNS. Likewise, Bhanja virus infection did not affect significantly the course of murine cryptococcosis. However, formalin-killed C. neoformans cells non-specifically increased production of antibodies against the virus infection in the animals.
Hubálek
Z
Z
Institute of Landscape Ecology, Academy of Sciences, Brno, Czech Republic.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002044:Bunyaviridae Infections / Q000276:immunology; D002490:Central Nervous System / Q000382:microbiology / Q000821:virology*; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000276:immunology* / Q000472:pathogenicity; D005557:Formaldehyde / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015164:Vaccines, Inactivated
D000276:Adjuvants, Immunologic; D015164:Vaccines, Inactivated; D005557:Formaldehyde