Remission of cancer chemotherapy-induced emesis during antidepressant therapy with nefazodone.
OBJECTIVE
To emphasize the importance of treating a major depressive episode in an elderly patient with small cell lung cancer (SCLC).


METHODS
A case report is described to illustrate the importance of treating depression in an elderly patient with SCLC undergoing chemotherapy.


RESULTS
During the course of antidepressant therapy with nefazodone, the patient also experienced a remission of cancer chemotherapy-induced emesis.


CONCLUSIONS
This case report suggests that the remission of emesis could be related to the 5-hydroxytryptamine (5-HT) antagonistic property of nefazodone.
Khouzam
H R
HR
VA Medical Center, Manchester, New Hampshire 03104-4098, USA.
Monteiro
A J
AJ
Gerken
M E
ME
D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D010879:Piperazines; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D012803:Sick Role; D014230:Triazoles / Q000009:adverse effects / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy / Q000523:psychology
D018687:Antidepressive Agents, Second-Generation; D010879:Piperazines; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; D014230:Triazoles; C051752:nefazodone