title: [Psychoses, mood, suicidal tendencies and clozapine].
abstract: Depression and mood disorders are frequently associated. They can be described as a part of schizophrenic symptomatology, observed as post-psychotic depression, be a part of a schizoaffective disorder or be a consequence of neuroleptic treatment. Suicide is the main risk of evolution in young schizophrenics and is often associated to depression. Despite methodological difficulties, a few studies demonstrate the efficacy of clozapine, one of the first atypical antipsychotic, in the treatment of depressive symptomatology in schizophrenics and schizoaffectives. This action remains controversial in the treatment of post-psychotic depression. This drug also contribute to reduce suicidality in a sample of chronic schizophrenics in an open study. This action has to be considered when we evaluate the risk-benefit of the prescription of clozapine.
authors.affiliation: CH Sainte-Marie, Clermont-Ferrand.
authors.forename: P M
authors.initials: PM
authors.lastname: Llorca
authors.forename: C
authors.initials: C
authors.lastname: Lançon
authors.forename: G
authors.initials: G
authors.lastname: Reine
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D015897:Comorbidity; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013405:Suicide / Q000523:psychology; D000092864:Suicide Prevention
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine
vernacular_title: Psychoses, humeur, suicidalité et clozapine.