Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone.
The superoxide (O2.-) scavenging activity and the neuroprotective effects of pterin-6-aldehyde (P6A), a xanthine oxidase inhibitor, were examined and compared with those of alpha-phenyl-N-tert-butyl nitrone (PBN), a spin trapping agent. The scavenging activity of P6A was more potent than that of PBN by 150-fold in neutrophil/phorbol myristate acetate O2.- generating system. P6A attenuated the neuronal damage with a much smaller dose and a greater efficiency than PBN in global brain ischemia in gerbils. These findings suggest that P6A is a more potent neuroprotective agent than PBN and has possible therapeutic effects against various diseases in which O2.- is involved.
Mori
H
H
Department of Anesthesia, Kyoto University Hospital, Japan.
Arai
T
T
Ishii
H
H
Adachi
T
T
Endo
N
N
Makino
K
K
Mori
K
K
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D003497:Cyclic N-Oxides; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005849:Gerbillinae; D008297:Male; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009589:Nitrogen Oxides / Q000494:pharmacology*; D011621:Pteridines / Q000494:pharmacology*; D011622:Pterins; D013113:Spin Labels; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D003497:Cyclic N-Oxides; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D009589:Nitrogen Oxides; D011621:Pteridines; D011622:Pterins; D013113:Spin Labels; C029217:phenyl-N-tert-butylnitrone; C005926:2-amino-4-hydroxy-6-formylpteridine; D014969:Xanthine Oxidase