title: Antibacterial activity of cured dental resin incorporating the antibacterial monomer MDPB and an adhesion-promoting monomer.
abstract: In this study, the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) and an adhesion-promoting phosphoric monomer were incorporated into Bis-GMA-based dental resin and its antibacterial activity after curing was investigated. The experimental resin containing MDPB and 10-methacryloyloxydecyl dihydrogen phosphate (MDP) was polymerized and washed with methanol, and the bacteriostatic and bactericidal effects against Streptococcus mutans were determined. Growth of S. mutans was strongly inhibited by contact with the surface of cured MDPB/MDP-containing resin, although the bactericidal effect was small. Cured MDPB/MDP-containing resin also showed an inhibitory effect against in vitro plaque formation on its surface by S. mutans. The bactericide immobilized in Bis-GMA-based resin demonstrated bacteriostatic activity as a contact antimicrobial even when adhesion-promoting phosphoric monomer was incorporated into the materials.
authors.affiliation: Department of Operative Dentistry, Osaka University Faculty of Dentistry, Suita, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Imazato
authors.forename: T
authors.initials: T
authors.lastname: Imai
authors.forename: R R
authors.initials: RR
authors.lastname: Russell
authors.forename: M
authors.initials: M
authors.lastname: Torii
authors.forename: S
authors.initials: S
authors.lastname: Ebisu
mesh_terms: D000269:Adhesives; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003188:Composite Resins; D003773:Dental Plaque; D006801:Humans; D008422:Materials Testing; D009055:Mouth / Q000382:microbiology; D011726:Pyridinium Compounds; D013295:Streptococcus mutans / Q000187:drug effects / Q000254:growth & development
chemical_list: D000269:Adhesives; D000900:Anti-Bacterial Agents; D003188:Composite Resins; D011726:Pyridinium Compounds; C089392:methacryloyloxydodecylpyridinium bromide