[Biphasic course of left ventricular dysfunction in a 22-year-old female with acute myocarditis].
METHODS
Two days before admission a 22-year-old woman developed general fatigue, nausea, headache and retrosternal pain. Physical examination was unremarkable.


METHODS
Erythrocyte sedimentation rate was increased to 20/48, C-reactive protein to 3.3 mg/dl, and there was evidence of myocardial damage (creatine kinase 609 U/l, creatine kinase-MB 42 U/l, troponine T 8.39 ng/ml); ST-segment elevations in I, II, III, aVF and V-V6 of the ECG. Echocardiography revealed clearly thickened myocardium, moderate but haemodynamically not significant pericardial effusion, as well as impaired left ventricular function. Antimyosin scintigraphy was very abnormal. Cardiac catheterization confirmed the left ventricular dysfunction, rise of left ventricular enddiastolic pressure to 17 mm Hg, and a markedly reduced cardiac output of 2.4 l/min. Myocardial biopsy showed severe myocarditis with marked myocytolysis and considerable lymphocytic infiltrations. Enteroviral RNA was demonstrated in the myocardium by polymerase chain reaction.


METHODS
The haemodynamics became normal within only 3 days. Myocardial biopsy after 6 months was unremarkable histologically and immunohistologically, and left ventricular function was also normal. However, while after a further 12 months myocardial biopsy remained normal and no virus was demonstrated, there was definite, though moderate, impairment in left ventricular function, indicating a dilated cardiomyopathy.


CONCLUSIONS
Even when histological and immunohistological evidence of healing of an acute viral myocarditis has been achieved, with complete normalization of left ventricular function, a dilated cardiomyopathy may subsequently develop. The pathophysiological mechanism of this occurrence remains unknown.
Lauer
B
B
Herzzentrum, Universität Leipzig.
Schulze
K
K
Kühl
U
U
Pauschinger
M
M
Schwimmbeck
P
P
Strauer
B E
BE
Schultheiss
H P
HP
D000208:Acute Disease; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001706:Biopsy; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D004232:Diuretics / Q000008:administration & dosage; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D009205:Myocarditis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics; D002097:C-Reactive Protein
Biphasischer Verlauf der linksventrikulären Funktion bei einer 22jährigen Patientin mit akuter Myokarditis.