title: [Angiostrongylus in the infant at Reunion and Mayotte. Apropos of 3 cases of eosinophilic meningitis including 1 fatal radiculomyeloencephalitis with hydrocephalus].
abstract: BACKGROUND
  Eosinophilic meningitis caused by Angiostrongylus cantonensis is widespread in Southeast Asia and Pacific islands. Adults develop a transient meningitis with a benign course but severe or fatal disease may occur in pediatric patients. CASE REPORT 1: A 11 months old boy living in Mayotte island was hospitalized some days after fever and skin rash with seizure status, coma, flaccid quadriplegia, absence of deep tendon reflexes, urinary retention and anal incontinence. Eosinophilia was observed in peripheral blood and in the cerebrospinal fluid. Secondary, he developed a triventricular hydrocephalus treated by a ventriculoperitoneal shunt. After 3 weeks, the child died. Retrospectively, the diagnosis of angiostrongylus infection was established with the help of serology. CASE REPORTS 2 AND 3: Two infants, 10 and 11 months old boys, living in Reunion island, developed fever and vomitings, irritability and, for one of them, a unilateral sixth cranial nerve palsy. There was eosinophilia in the peripheral blood and in the cerebrospinal fluid. All symptoms progressively disappeared with complete recovery. The suspected diagnosis of angiostrongylus infection was confirmed by the serology.
  
  
  CONCLUSIONS
  We report the first case of Angiostrongylus cantonensis infection in the French island of Mayotte (Comoro Islands) and we confirm the presence of this disease in Reunion island. In this Indian Ocean area, eosinophilic meningitis occurs most of the time in infants with sometimes severe radiculomyeloencephalitic forms. The origin of these occasionally massive infections is the giant African snail Achatina fulica. For a child with meningitis living in Reunion or Mayotte, or coming back from these 2 islands, Angiostrongylus cantonensis infection must be evoked, especially if there is a blood eosinophilia. Since efficiency of antiparasitic treatment is nowadays not proved, information must be given to people living in exposed areas in view to limit incidence of this disease.
authors.affiliation: Service de pédiatrie, Centre hospitalier départemental F. Guyon, St. Denis, France.
authors.forename: D
authors.initials: D
authors.lastname: Graber
authors.forename: M C
authors.initials: MC
authors.lastname: Jaffar
authors.forename: T
authors.initials: T
authors.lastname: Attali
authors.forename: J
authors.initials: J
authors.lastname: Poisson
authors.forename: M
authors.initials: M
authors.lastname: Renouil
authors.forename: J L
authors.initials: JL
authors.lastname: Alessandri
authors.forename: J C
authors.initials: JC
authors.lastname: Combes
mesh_terms: D017185:Angiostrongylus cantonensis; D000818:Animals; D017507:Comoros; D004679:Encephalomyelitis / Q000469:parasitology*; D004802:Eosinophilia / Q000469:parasitology*; D017809:Fatal Outcome; D006801:Humans; D006849:Hydrocephalus / Q000469:parasitology*; D007223:Infant; D008297:Male; D008581:Meningitis / Q000469:parasitology*; D017508:Reunion; D017206:Strongylida Infections
vernacular_title: L'angiostrongylose chez le nourrisson à la Réunion et à Mayotte. A propos de trois méningites à éosinophiles dont une radiculomyéloencéphalite avec hydrocéphalie fatale.