title: [Infants of diabetic mothers (IDM). I -- Macrosomia and growth factors].
abstract: OBJECTIVE
  The objective of this study was to determine the incidence of macrosomia in infants of diabetic mothers (IDM) and to analyze its possible correlation with insulin, C-peptide, growth hormone (GH) and IGF-I levels in umbilical cord blood.
  
  
  METHODS
  A prospective study of 58 IDM and 58 control newborns (33 males and 25 females in both groups) was carried out.
  
  
  RESULTS
  The incidence of macrosomia was 25.8% in the IDM group and 61.5% in the IIDDM group (infant of insulin-dependent diabetic mother) compared to 5% in the control group. There was a positive correlation between maternal Hgb Alc levels in the third trimester of gestation and insulin and C-peptide levels with newborn weight in the IDM group (especially in the IIDDM group). IGF-I levels were positively correlated with newborn weight in both control and IDM groups. There was no correlation between GH and IGF-I levels in any group.
authors.affiliation: Servicio de Endocrinología, Hospital Infantil La Paz, Madrid.
authors.forename: G
authors.initials: G
authors.lastname: Martín Carballo
authors.forename: G
authors.initials: G
authors.lastname: Fernández Cano
authors.forename: C
authors.initials: C
authors.lastname: Grande Aragón
authors.forename: J
authors.initials: J
authors.lastname: Méndez Alavedra
authors.forename: F
authors.initials: F
authors.lastname: Hawkins Carranza
authors.forename: R
authors.initials: R
authors.lastname: Gracia Bouthelier
mesh_terms: D002096:C-Peptide / Q000097:blood; D002657:Child Development; D003924:Diabetes Mellitus, Type 2; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005320:Fetal Macrosomia / Q000097:blood* / Q000453:epidemiology; D006454:Hemoglobins / Q000032:analysis; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D008297:Male; D011446:Prospective Studies
chemical_list: D002096:C-Peptide; D006454:Hemoglobins; D007328:Insulin; D019382:Human Growth Hormone
vernacular_title: El recién nacido hijo de madre diabética (RNHMD). I--Macrosomia y factores de crecimiento.