Age-related marrow conversion in the proximal metaphysis of the femur: evaluation with T1-weighted MR imaging.
OBJECTIVE
To determine the normal chronologic changes in fatty marrow conversion of the proximal femoral metaphysis at magnetic resonance (MR) imaging.


METHODS
The "marrow conversion index," (signal intensity of the proximal femoral metaphysis divided by signal intensity of the greater trochanter) x 100, was measured in 182 hips of 91 patients who had no evidence of osteonecrosis or diseases involving bone marrow, no history of steroid treatment, and no other risk factors for osteonecrosis. The results were evaluated according to patient age and sex.


RESULTS
The index showed a progressive linear increase with age regardless of sex. The index was 65.4% +/- 5.6 (standard deviation) in patients aged 15-19 years and increased monotonously with age to 87.5% +/- 7.0 in patients aged 60-79 years. Simple linear regression of the index according to age group showed that the marrow conversion index is roughly equal to 63 + 4 x Z (p < .001), where Z is 1.5 for patients aged 15-19 years, 2.0 for patients aged 20-29 years, 3.0 for patients aged 30-39 years, 4.0 for patients aged 40-49 years, 5.0 for patients aged 50-59 years, and 6.0 for patients aged 60-79 years.


CONCLUSIONS
There is a linear association of marrow conversion index and age. The estimating equation may provide baseline information for the marrow conversion index.
Koo
K H
KH
Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, USA.
Dussault
R
R
Kaplan
P
P
Kim
R
R
Ahn
I O
IO
Christopher
J
J
Song
H R
HR
Wang
G J
GJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001853:Bone Marrow / Q000033:anatomy & histology* / Q000502:physiology; D005260:Female; D005269:Femur / Q000033:anatomy & histology* / Q000502:physiology; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged