title: Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant.
abstract: We describe two patients with acute myeloid leukaemia (AML) associated with erythrophagocytosis and a pericentric inversion of chromosome 8, inv(8)(p11q13). The haematological features were indistinguishable from those of patients with the t(8;16) syndrome and its variants. Our observations emphasize the importance of the breakpoint at 8p11 and the possible involvement of the MOZ gene in all these cases.
authors.affiliation: Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London.
authors.forename: S
authors.initials: S
authors.lastname: Coulthard
authors.forename: A
authors.initials: A
authors.lastname: Chase
authors.forename: K
authors.initials: K
authors.lastname: Orchard
authors.forename: A
authors.initials: A
authors.lastname: Watmore
authors.forename: A
authors.initials: A
authors.lastname: Vora
authors.forename: J M
authors.initials: JM
authors.lastname: Goldman
authors.forename: D M
authors.initials: DM
authors.lastname: Swirsky
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D019457:Chromosome Breakage; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004913:Erythrocytes, Abnormal / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D010587:Phagocytosis / Q000502:physiology*