title: Restenosis after coronary stenting in current clinical practice.
abstract: BACKGROUND
  Randomized trials have demonstrated that planned coronary stenting may lower restenosis rate in patients with de novo short lesions. In a prospective study we sought to determine the frequency of restenosis, reocclusion, and adverse cardiovascular events after coronary stenting in a series of 258 consecutive nonselected patients, including those with complex lesions not fulfilling past and ongoing randomized trial criteria for stent implantation.
  
  
  METHODS
  Criteria for stenting were as follows: (1) dissection associated with occlusion or threatened closure, (2) a residual percentage stenosis > 30% or nonocclusive dissection, (3) restenotic lesion or chronic total occlusion.
  
  
  RESULTS
  In most cases (89%) the target lesion had two or more unfavorable morphologic characteristics, whereas only 11% of target lesions could be classified as type A or B1 lesions. Overall, the 6-month restenosis rate was 23%. By use of subgroup analysis restenosis rate was found to range widely, from 11% to 46%. With multivariate analysis, only four variables were found to be independently related to restenosis: age > 63 years (odds ratio [OR] = 2.651, p = 0.011), female sex (OR = 3.807, p = 0.002), lesion length > 12 mm (OR 3.185, p = 0.002), and type C lesion (OR 2.527, p = 0.014).
  
  
  CONCLUSIONS
  Results from randomized trials on coronary stenting cannot be extrapolated to current clinical practice because most of the treated lesions do not fulfill the criteria adopted in these studies for stent implantation. The restenosis rate is nearly four times greater for long and complex lesions treated by multiple stent implantation as compared with simple lesions, and additional studies need to be performed to evaluate the efficacy of stenting on these lesions.
authors.affiliation: Division of Cardiology, Careggi Hospital, Florence, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Antoniucci
authors.forename: R
authors.initials: R
authors.lastname: Valenti
authors.forename: G M
authors.initials: GM
authors.lastname: Santoro
authors.forename: L
authors.initials: L
authors.lastname: Bolognese
authors.forename: M
authors.initials: M
authors.lastname: Trapani
authors.forename: G
authors.initials: G
authors.lastname: Cerisano
authors.forename: V
authors.initials: V
authors.lastname: Boddi
authors.forename: P F
authors.initials: PF
authors.lastname: Fazzini
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography; D003327:Coronary Disease / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012008:Recurrence; D012737:Sex Factors; D015607:Stents; D016896:Treatment Outcome