title: The pufferfish SLP-1 gene, a new member of the SCL/TAL-1 family of transcription factors.
abstract: The SCL/TAL-1 gene encodes a basic helix-loop-helix (bHLH) transcription factor essential for the development of all hemopoietic lineages and also acts as a T-cell oncogene. Four related genes have been described in mammals (LYL-1, TAL-2, NSCL1, and NSCL2), all of which exhibit a high degree of sequence similarity to SCL/TAL-1 in the bHLH domain and two of which (LYL-1 and TAL-2) have also been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia. In this study we describe the identification and characterization of a pufferfish gene termed SLP-1, which represents a new member of this gene family. The genomic structure and sequence of SLP-1 suggests that it forms a subfamily with SCL/TAL-1 and LYL-1 and is most closely related to SCL/TAL-1. However, unlike SCL/TAL-1, SLP-1 is widely expressed. Sequence analysis of a whole cosmid containing SLP-1 shows that SLP-1 is flanked upstream by a zinc finger gene and a fork-head-domain gene and downstream by a heme-oxygenase and a RING finger gene.
authors.affiliation: Department of Haematology, MRC Centre, University of Cambridge, United Kingdom.
authors.forename: B
authors.initials: B
authors.lastname: Göttgens
authors.forename: J G
authors.initials: JG
authors.lastname: Gilbert
authors.forename: L M
authors.initials: LM
authors.lastname: Barton
authors.forename: S
authors.initials: S
authors.lastname: Aparicio
authors.forename: K
authors.initials: K
authors.lastname: Hawker
authors.forename: S
authors.initials: S
authors.lastname: Mistry
authors.forename: M
authors.initials: M
authors.lastname: Vaudin
authors.forename: A
authors.initials: A
authors.lastname: King
authors.forename: D
authors.initials: D
authors.lastname: Bentley
authors.forename: G
authors.initials: G
authors.lastname: Elgar
authors.forename: A R
authors.initials: AR
authors.lastname: Green
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D004268:DNA-Binding Proteins / Q000235:genetics*; D029941:Fish Proteins; D005400:Fishes, Poisonous / Q000235:genetics*; D015870:Gene Expression; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D029941:Fish Proteins; D011518:Proto-Oncogene Proteins; C111555:SLP-1 protein, Fugu rubripes; D014157:Transcription Factors