title: Intrarenal arteriosclerosis and impairment of kidney function in NIDDM subjects.
abstract: It is currently under debate whether the pathogenesis of end-stage renal failure in non-insulin-dependent diabetes mellitus (NIDDM) is a consequence of microangiopathy alone. The aim of this study was to investigate intrarenal arteriosclerosis and its correlation with kidney function in NIDDM. In 36 diabetic subjects, and in 10 age- and sex-matched healthy control subjects we measured kidney volume and resistive index of the interlobar arteries by duplex Doppler ultrasonography. Clinical and metabolic parameters, renal function and vascular sequelae of the disease were also evaluated. In diabetic subjects resistive index (median 0.72, range 0.54-0.79) was higher than in control subjects (median 0.62, range 0.57-0.66) (2p < 0.002). Kidney volume and resistive index correlated with age (p < 0.004), body mass index (p < 0.001), mean blood pressure (p < 0.001), total and LDL cholesterol (p < 0.01) and creatinine clearance (p < 0.001 and < 0.01, respectively). Kidney volume also correlated with HbA1 (p < 0.01) and resistive index with uric acid (p < 0.01). Lower body macroangiopathy was associated with increased resistive index and reduced kidney volume (2p < 0.05), while upper body macroangiopathy and microangiopathy were not. Our data suggest that macroangiopathy rather than microangiopathy is mainly responsible for impairment of kidney function in NIDDM. The resistive index of interlobar arteries seems to be a reliable marker of intrarenal arteriosclerosis and can be used as a non-invasive, easily available parameter of its evolution.
authors.affiliation: Cattedra di Clinica Medica RR, Dipartimento di Medicina Interna, Università di Genova, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Boeri
authors.forename: L E
authors.initials: LE
authors.lastname: Derchi
authors.forename: C
authors.initials: C
authors.lastname: Martinoli
authors.forename: G
authors.initials: G
authors.lastname: Simoni
authors.forename: L
authors.initials: L
authors.lastname: Sampietro
authors.forename: D
authors.initials: D
authors.lastname: Storace
authors.forename: L
authors.initials: L
authors.lastname: Ponte
authors.forename: C
authors.initials: C
authors.lastname: Calvi
authors.forename: M
authors.initials: M
authors.lastname: Repetto
authors.forename: C
authors.initials: C
authors.lastname: Robaudo
authors.forename: M
authors.initials: M
authors.lastname: Maiello
mesh_terms: D001161:Arteriosclerosis / Q000097:blood / Q000503:physiopathology*; D001794:Blood Pressure; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D003404:Creatinine / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology / Q000098:blood supply / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000000981:diagnostic imaging; D018616:Ultrasonography, Doppler, Duplex
chemical_list: D008078:Cholesterol, LDL; D003404:Creatinine; D006442:Glycated Hemoglobin