Amino acid and nucleotide sequences of human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase cDNA.
Deficiency of enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase (peroxisomal bifunctional enzyme), one of the enzymes of the peroxisomal beta-oxidation system, leads to clinical manifestations resembling Zellweger syndrome with hypotonia, psychomotor delay, hepatomegaly, typical facial appearance and accumulation of very long-chain fatty acids. The nucleotide sequence of the human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase cDNA has been reported by Hoefler and colleagues; however, we have found some amino acid differences from our originally isolated cDNA. Contrary to the findings described in a previous paper, we report here the cDNA sequence of human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase in which there are 9 authenticated amino acid alterations.
Fukuda
S
S
Department of Pediatrics, Gifu University School of Medicine, Japan.
Suzuki
Y
Y
Shimozawa
N
N
Zhang
Z
Z
Orii
T
T
Aoyama
T
T
Hashimoto
T
T
Kondo
N
N
D015094:3-Hydroxyacyl CoA Dehydrogenases / Q000235:genetics*; D001483:Base Sequence; D018076:DNA, Complementary; D004746:Enoyl-CoA Hydratase / Q000235:genetics*; D006801:Humans; D007535:Isomerases; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000235:genetics*; D063994:Peroxisomal Bifunctional Enzyme; D017422:Sequence Analysis, DNA
D018076:DNA, Complementary; D009097:Multienzyme Complexes; D015094:3-Hydroxyacyl CoA Dehydrogenases; C576253:EHHADH protein, human; D004746:Enoyl-CoA Hydratase; D063994:Peroxisomal Bifunctional Enzyme; D007535:Isomerases