Translocation (5;10)(q13;q26) in acute monoblastic leukemia.
We report a case of acute monoblastic leukemia [French-American-British (FAB) M5a] observed in a 38-year-old man and associated at diagnosis with a t(5;10)(q13;q26) found in cells from a bone marrow culture. The patient survived only 2 months after diagnosis. t(5;10) as a solitary chromosome abnormality has not been previously reported in M5a, and, in the case that we describe, it appears to be correlated with a poor prognosis.
Pernice
F
F
Cattedra e Divisione di Medicina Interna, Università degli Studi di Messina, Italy.
Musolino
C
C
Mazza
G
G
Puglisi
D
D
Squadrito
G
G
Frisina
N
N
Squadrito
G
G
D000328:Adult; D002871:Chromosome Banding; D002879:Chromosomes, Human, Pair 10; D002895:Chromosomes, Human, Pair 5; D017809:Fatal Outcome; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic