title: Severe cerebellar swelling and thrombotic thrombocytopenic purpura associated with FK506.
abstract: Two patients with CsA-associated neurotoxicity developed severe cerebellar swelling and thrombotic thrombocytopenic purpura after switching to FK506 and high-dose corticosteroids. The prodrome of CsA-associated neurotoxicity, TTP and hypertension while receiving FK506, and high-dose corticosteroids could all be implicated in the development of this syndrome. Close monitoring of patients receiving FK506 and high-dose corticosteroids, for the development of TTP is warranted. Early radiological examination should also be considered in such patients to allow early surgical intervention.
authors.affiliation: Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: H
authors.initials: H
authors.lastname: Tezcan
authors.forename: W
authors.initials: W
authors.lastname: Zimmer
authors.forename: R
authors.initials: R
authors.lastname: Fenstermaker
authors.forename: G P
authors.initials: GP
authors.lastname: Herzig
authors.forename: J
authors.initials: J
authors.lastname: Schriber
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D002531:Cerebellum / Q000187:drug effects*; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced*; D016559:Tacrolimus / Q000009:adverse effects*; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus