title: Changes in endogenous benzodiazepine-like compound levels during the course of fulminant hepatic failure: potential effects of decreased renal function.
abstract: The pathogenetic agents which cause encephalopathy due to fulminant hepatic failure are still under debate. Ammonia and benzodiazepine-like compounds are two of the most important agents considered, so far. Herein, we report the levels of benzodiazepine-like compounds in serum and in urine and of venous ammonia measured during the course of the disease (30 days). The patient rapidly developed stage IV encephalopathy with high levels of ammonia and with only a slight increase of benzodiazepine-like compounds. At that moment, the levels of these compounds were similar to those recorded in the blood when the patient regained full consciousness 28 days later. During the course of the disease, there was a 10-fold increase of benzodiazepine-like compounds in serum which was recorded in parallel with an impaired excretion due to oliguria. This observation seems to indicate that encephalopathy may develop in the absence of significantly increased levels of these compounds and that their episodic increase during fulminant hepatic failure may be an epiphenomenon linked with several factors such as impaired renal function.
authors.affiliation: Department of Internal Medicine, University of Modena, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Zeneroli
authors.forename: I
authors.initials: I
authors.lastname: Venturini
authors.forename: R
authors.initials: R
authors.lastname: Avallone
authors.forename: F
authors.initials: F
authors.lastname: Farina
authors.forename: L
authors.initials: L
authors.lastname: Miglioli
authors.forename: R
authors.initials: R
authors.lastname: Cosenza
authors.forename: R
authors.initials: R
authors.lastname: Amedei
authors.forename: G
authors.initials: G
authors.lastname: Ardizzone
authors.forename: M
authors.initials: M
authors.lastname: Centanaro
authors.forename: A
authors.initials: A
authors.lastname: Arrigo
authors.forename: M
authors.initials: M
authors.lastname: Baraldi
mesh_terms: D000328:Adult; D000641:Ammonia / Q000097:blood; D001569:Benzodiazepines / Q000378:metabolism*; D005260:Female; D006501:Hepatic Encephalopathy / Q000378:metabolism*; D006801:Humans
chemical_list: D001569:Benzodiazepines; D000641:Ammonia