Fc gamma RIIa polymorphism in systemic lupus erythematosus.
OBJECTIVE
Polymorphism of the phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupus nephritis. Fc gamma RIIa is biallelic, the alleles R and H each having a gene frequency of about 50%. Nephritis has been associated with an increased frequency of the R allele. The frequency of common Fc gamma RIIa alleles was examined in white subjects from the United Kingdom and Greek subjects with systemic lupus erythematosus (SLE) and healthy controls.


METHODS
Fc gamma RIIa genotyping was performed using a single step polymerase chain reaction technique, which differentiates the two major alleles, R and H. Two study populations were examined: (a) white subjects from the United Kingdom: 66 controls and 81 with SLE (19 of whom had renal disease) and (b) Greek: 52 controls and 42 with SLE (19 with renal disease).


RESULTS
No significant relation was observed between Fc gamma RIIa genotype and susceptibility to SLE or SLE nephritis.


CONCLUSIONS
The Fc gamma RIIa R allele does not seem to be associated with SLE (with or without renal disease) in our United Kingdom white or Greek populations.
Smyth
L J
LJ
ARC Epidemiology Unit, University of Manchester.
Snowden
N
N
Carthy
D
D
Papasteriades
C
C
Hajeer
A
A
Ollier
W E
WE
D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D006115:Greece; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000276:immunology*; D008181:Lupus Nephritis / Q000235:genetics / Q000276:immunology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D006113:United Kingdom
D015703:Antigens, CD; C080568:Fc gamma receptor IIA; D017452:Receptors, IgG