title: Can cerebrovascular reactivity be assessed by dynamic susceptibility contrast-enhanced MRI?
abstract: The acetazolamide (ACZ) test is performed to evaluate the decrease in cerebral perfusion pressure (CPP) by investigation of vasomotor reactivity (VMR). Our aim was to study cerebral blood flow and blood volume changes induced by the ACZ test in healthy control subjects using dynamic susceptibility contrast-enhanced gradient-echo MRI (DSC-MRI). A FLASH sequence was used to produce susceptibility-weighted images during an intravenous injection of 0.1 mmol/kg gadopentetate dimeglumine (Gd-DTPA). After the first dynamic study, 1 g acetazolamide was given intravenously and 10 min later a second bolus of Gd-DTPA was injected. Using the indicator-dilution theory, relative cerebral blood volume and relative cerebral blood flow were estimated. In healthy subjects the ACZ test induced a significant increase in relative blood volume (from 80.5 +/- 10.7 to 113.4 +/- 11.9) and relative blood flow (from 5.73 +/- 0.96 to 7.5 +/- 0.97), symmetrically in the cerebral hemispheres. This approach might be promising in the understanding of cerebral haemodynamics in patients with vascular disorders.
authors.affiliation: Department of Radiology, Creatis UMR CNRS 5515, Neurological Hospital, Lyon, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Berthezene
authors.forename: N
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: R
authors.initials: R
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Damien
authors.forename: L
authors.initials: L
authors.lastname: Cinotti
authors.forename: P
authors.initials: P
authors.lastname: Adeleine
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
authors.forename: J C
authors.initials: JC
authors.lastname: Froment
mesh_terms: D000086:Acetazolamide; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002257:Carbonic Anhydrase Inhibitors; D003287:Contrast Media; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014666:Vasomotor System / Q000187:drug effects / Q000502:physiology
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D003287:Contrast Media; D019786:Gadolinium DTPA; D000086:Acetazolamide