[Relationship between alcoholism and CYP2E1 genotypes].
The genotype of the CYP2E1 loci in 36 alcoholic and 42 non-alcoholic (healthy) Japanese were investigated to examine the relationship between the polymorphisms of CYP2E1 (C/D) and the susceptibility to alcohol dependence. There was a significant (df = 1, chi 2 = 4.39, p < 0.05) difference in CYP2E1 CD (heterozygote) genotype frequency between alcohol dependents (56%) and controls (33%), suggesting that the CD (heterozygote) genotype of CYP2E1 may have something to the risk of developing alcoholism in Japanese, whereas DD (homozygote) genotype was high among controls.
Sakae
Y
Y
Department of Neuropsychiatry, Kagawa Medical University, Japan.
Iwahashi
K
K
Ameno
S
S
Ameno
K
K
Okada
N
N
Nakamura
K
K
Watanabe
M
M
Suwaki
H
H
Ijiri
I
I
Harada
S
S
D000328:Adult; D000437:Alcoholism / Q000201:enzymology* / Q000235:genetics*; D044466:Asian People; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012306:Risk
D019392:Cytochrome P-450 CYP2E1