Adenosquamous carcinoma: a case report with immunohistochemical evaluation.
The histogenetic origin of adenosquamous carcinoma, a high-grade variant of malignant epithelial neoplasm, has long been debated. We report a case that clearly demonstrated a mucosal surface epithelial origin. This concept was supported through histologic analysis of hematoxylin- and eosin-stained sections, as well as by the pattern of immunohistochemical reactivity with antibodies directed against low and high molecular weight cytokeratins, cell adhesion molecules (CAM 5.2), and carcinoembryonic antigens. The histologic differential diagnosis, biological behavior, and prognosis of adenosquamous carcinoma are also examined.
Abdelsayed
R A
RA
Oral and Maxillofacial Pathology Department, School of Dentistry, Medical College of Georgia, Augusta 30912-1110, USA.
Sangueza
O P
OP
Newhouse
R F
RF
Singh
B S
BS
D000328:Adult; D002272:Carcinoembryonic Antigen / Q000032:analysis; D018196:Carcinoma, Adenosquamous / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D015815:Cell Adhesion Molecules / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D014062:Tongue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D007633:Keratins