title: Kinetics of fluid delivery from methylcellulose sponges.
abstract: OBJECTIVE
  The authors quantitatively evaluate the kinetics of fluid transfer from microsurgical sponges in a laboratory model to understand the kinetics of mitomycin C (MMC) delivery.
  
  
  METHODS
  The amount of fluid transferred from soaked methylcellulose (Weck-cel, Weck Inc., Durham, NC, U.S.A.) sponges to small pieces of hydrated or dry filter paper used to simulate episcleral tissue and Tenon fascia was measured as a function of time, sponge size, hydration status of the filter paper, and technique of sponge application.
  
  
  RESULTS
  The time course of fluid delivery from methylcellulose sponges to filter paper was nonlinear and characterized by a rapid delivery phase over the first 15 to 30 seconds, followed by a slow phase extending to at least 5 minutes. Sponge size and baseline hydration of the paper significantly influenced the rate and amount of fluid delivered, as did replacing the sponge every minute with a new sponge.
  
  
  CONCLUSIONS
  The transfer of fluid from a microsurgical sponge displays nonlinear kinetics, with the majority of delivery occurring in the first 15 to 30 seconds. Sponge size, hydration of the recipient tissue, and technique of sponge application are significant variables influencing the amount of fluid, and therefore mitomycin C, delivered.
authors.affiliation: Department of Ophthalmology, Medical College of Georgia, Augusta 30912, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Brooks
authors.forename: M L
authors.initials: ML
authors.lastname: Laird
authors.forename: D M
authors.initials: DM
authors.lastname: Marcus
authors.forename: M H
authors.initials: MH
authors.lastname: Johnson
authors.forename: J I
authors.initials: JI
authors.lastname: Ramage
authors.forename: K
authors.initials: K
authors.lastname: Green
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000295:instrumentation; D008747:Methylcellulose; D016685:Mitomycin / Q000493:pharmacokinetics*; D008954:Models, Biological; D015503:Surgical Sponges
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin; D008747:Methylcellulose