title: The presence of cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA) in the course of subacute bacterial endocarditis with glomerular involvement, coincidence or association?
abstract: Antineutrophil cytoplasmic antibodies positivity with cytoplasmic pattern (C-ANCA) and proteinase-3 (PR-3) specificity was found in two patients with both subacute bacterial endocarditis (SBE) and glomerular involvement. Renal biopsy showed membranoproliferative glomerulonephritis in one case and focal segmental glomerulonephritis in the second case. Immunofluorescence study showed granular immune deposits in both cases evocating immune complex glomerulonephritis. Renal and biological manifestations disappeared with clinical improvement secondary to antibiotherapy. Physicians have to consider the possible occurrence of such C-PR-3 ANCA, claimed to be specific markers for Wegener's granulomatosis, in infectious diseases such as SBE. Hence we focus on the necessity of performing a renal biopsy with light microscopy and immunofluorescence studies in all patients with ANCA associated glomerular disease.
authors.affiliation: Service de Néphrologie, CHU Angers, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Subra
authors.forename: C
authors.initials: C
authors.lastname: Michelet
authors.forename: J
authors.initials: J
authors.lastname: Laporte
authors.forename: F
authors.initials: F
authors.lastname: Carrere
authors.forename: P
authors.initials: P
authors.lastname: Reboul
authors.forename: F
authors.initials: F
authors.lastname: Cartier
authors.forename: J P
authors.initials: JP
authors.lastname: Saint-André
authors.forename: A
authors.initials: A
authors.lastname: Chevailler
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology; D004698:Endocarditis, Subacute Bacterial / Q000150:complications / Q000276:immunology*; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology*; D015433:Glomerulonephritis, Membranous / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D053146:Myeloblastin; D012697:Serine Endopeptidases / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001324:Autoantigens; D012697:Serine Endopeptidases; D053146:Myeloblastin