Soluble interleukin 2 receptor in dialyzed patients.
Azotemic patients are usually characterized by a state of so-called preactivation resulting in excessive expression of interleukin 2 receptors (IL-2R) on T lymphocytes. The etiological mechanism of this preactivation is, however, still speculative. We studied the serum level of the soluble form of IL-2R (sIL-2R) in azotemic patients on either hemodialysis (HD) (n = 49) or continuous ambulatory peritoneal dialysis (CAPD) (n = 45). Both patient groups had significantly higher sIL-2R levels (1,750+/-664 U/ml in the HD group and 1,769+/-647 U/ml in the CAPD group, respectively) p < 0.00001 as compared to the normal control group (511+/-436 U/ml). However, there was no significant difference between the levels of the HD and CAPD group patients. When clinical parameters were studied for their influence on sIL-2R levels, none of the following caused any significant changes: blood transfusion, type of dialyzer used, type of dialysis fluid used, treatment with erythropoietin, hepatitis B infection, or liver function profile. We conclude that chronic renal failure per se is the major cause of the preactivation of T lymphocytes. The modes of treatment and various clinical variables in these patients have no significant influence on sIL-2R levels.
Shu
K H
KH
Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taiwan.
Lu
Y S
YS
Cheng
C H
CH
Lian
J D
JD
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008213:Lymphocyte Activation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis* / Q000097:blood / Q000737:chemistry; D006435:Renal Dialysis; D012995:Solubility; D013601:T-Lymphocytes / Q000378:metabolism*; D014511:Uremia / Q000097:blood* / Q000628:therapy
D015375:Receptors, Interleukin-2