Role of neuropeptide Y in cold stress-induced hypertension.
Chronic cold stress (4 degrees C) produced a sustained increase in mean arterial pressure in both normotensive and borderline hypertensive rats (BHR). The high blood pressure in BHRs was significantly reversed by a neuropeptide Y (NPY) Y1 receptor antagonist suggesting that NPY is involved in mediating stress-induced hypertension. Corresponding increases in adrenal NPY messenger RNA and NPY immunoreactivity were found during the stress; furthermore, chronic cold stress also potentiated the pressor response of rats to a subsequent acute stress test in which NPY has been shown to play a role. These results suggest that chronic cold stress-induced hypertension is mediated by elevated NPY release and vascular tone as a result of increased NPY gene expression and storage.
Han
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Department of Pharmacological and Physiological Science, St. Louis University Health Science Center, MO 63104, USA. hans@slu.edu
Chen
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X
Cox
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B
Yang
C L
CL
Wu
Y M
YM
Naes
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L
Westfall
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T
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003080:Cold Temperature / Q000009:adverse effects*; D015870:Gene Expression; D006339:Heart Rate / Q000502:physiology; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D009478:Neuropeptide Y / Q000031:analogs & derivatives / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D017476:Receptors, Neuropeptide Y / Q000819:agonists / Q000502:physiology; D013312:Stress, Physiological / Q000150:complications* / Q000503:physiopathology*
D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; C062259:neuropeptide Y, Leu(31)-Pro(34)-