title: [Adaptation of Crimean-Congo hemorrhagic fever virus to culture in Vero-E6 cells].
abstract: Adaptation of the Crimean-Congo hemorrhagic fever (CCHF) virus to continuous culturing in Vero-E6 cells was studied by coculturing of infected and intact cells. Adapted strain Hoja-A exerted a complete cytocidal effect and was characterized by a high level of virus accumulation in the early period of the infection. The resultant strain survived through more than 80 passages and retained the newly acquired properties; lyophilized, it can be stored for a long time. Availability of such a strain opens new vistas in studies of the CCHF agent.
authors.forename: S E
authors.initials: SE
authors.lastname: Smirnova
authors.forename: G G
authors.initials: GG
authors.lastname: Karganova
authors.forename: L V
authors.initials: LV
authors.lastname: Gmyl'
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D005612:Freeze Drying; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000472:pathogenicity / Q000502:physiology*; D012692:Serial Passage; D014709:Vero Cells
vernacular_title: Adaptatsiia virusa Krymskoĭ-Kongolezskoĭ gemorragicheskoĭ likhoradki k kul'ture kletok Vero-E6.