title: Thunderclap headache caused by Erve virus?
abstract: Systematic studies of a possible human neuropathogenicity of the Erve virus have not yet been carried out. In a randomized, blind study 166 patients with viral encephalitis, 46 patients with cerebral hemorrhage, 72 patients with "thunderclap" headache, and 205 healthy blood donors were examined by indirect immunofluorescence for Erve virus antibodies. None of the patients with encephalitis, two patients with cerebral hemorrhage (4.3%), 10 patients with thunderclap headache (13.9%; p < 0.0001), and two blood donors (1.0%) exhibited antibodies against the Erve virus. These results suggest a human pathogenicity of the Erve virus for the first time.
authors.affiliation: Department of Neurology, University Hospital of Saarland, Homburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Treib
authors.forename: G
authors.initials: G
authors.lastname: Dobler
authors.forename: A
authors.initials: A
authors.lastname: Haass
authors.forename: W
authors.initials: W
authors.lastname: von Blohn
authors.forename: M
authors.initials: M
authors.lastname: Strittmatter
authors.forename: G
authors.initials: G
authors.lastname: Pindur
authors.forename: G
authors.initials: G
authors.lastname: Froesner
authors.forename: K
authors.initials: K
authors.lastname: Schimrigk
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002043:Bunyaviridae / Q000302:isolation & purification*; D002044:Bunyaviridae Infections / Q000150:complications*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000821:virology; D003937:Diagnosis, Differential; D018792:Encephalitis, Viral / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006261:Headache / Q000209:etiology* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000914:Antibodies, Viral