title: [Alternation of protease inhibitors and hemostasis system in treatment of spontaneous pneumothorax].
abstract: 3 groups of 37 patients were examined, in which for treatment of spontaneous pneumothorax drainage of pleural cavity and medicamentous pleurodesis with tetracycline hydrochloride and 4% solution of sodium bicarbonate were used. Interdependence of clinical criteria and level of protease inhibitors were evaluated, as well as the basic components of hemostasis. The best effectiveness of treatment in carrying out chemical pleurodesis was demonstrated, especially when 4% sodium bicarbonate solution was used. At the same time the application of this agent has evoked the most evident changes in values of hemostasis and protease inhibitors. The possibility of use of the above mentioned biochemical in dices together with clinical criteria for the evaluation of effectiveness of treatment of the unspecific spontaneous pneumothorax is stressed.
authors.forename: M M
authors.initials: MM
authors.lastname: Abakumov
authors.forename: V A
authors.initials: VA
authors.lastname: Abrosimov
authors.forename: O A
authors.initials: OA
authors.lastname: Markova
authors.forename: V B
authors.initials: VB
authors.lastname: Khvatov
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D004322:Drainage / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008297:Male; D018700:Pleurodesis / Q000379:methods*; D011030:Pneumothorax / Q000097:blood / Q000201:enzymology / Q000628:therapy*; D011480:Protease Inhibitors / Q000097:blood*; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D013752:Tetracycline / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D011480:Protease Inhibitors; D017693:Sodium Bicarbonate; D013752:Tetracycline
vernacular_title: Izmenenie ingibitorov proteaz i sistemy gemostaza pri lechenii spontannogo pnevmotoraksa.