[Interaction of L-glutamic acid with human T-lymphocytes].
A specific interaction of [3H]Glu with T lymphocytes from the blood of healthy donors (Kd = 0.236 microM) was revealed and described. It was found that unlabeled quisqualate, a structural analogue of L-glutamic acid, and unlabeled dipeptides Ala-Glu, Glu-Ala, and Glu-Glu competitively inhibit the specific binding of [3H]Glu to T lymphocytes (with Ki 0.19, 2.4, 3.4, and 1.2 microM, respectively). Binding experiments with conjugates of labeled and unlabeled glutamic acid with dextran showed that the receptors of [3H]Glu are localized on the outer surface of the plasma membrane of T lymphocytes.
Kostanyan
I A
IA
Navolotskaya
E V
EV
Nurieva
R I
RI
Zav'ialov
V P
VP
Lipkin
V M
VM
D001667:Binding, Competitive / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D018698:Glutamic Acid / Q000097:blood / Q000378:metabolism*; D006801:Humans; D016318:Quisqualic Acid / Q000494:pharmacology*; D017470:Receptors, Glutamate / Q000378:metabolism*; D013237:Stereoisomerism; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*
D004151:Dipeptides; D018690:Excitatory Amino Acid Agonists; D017470:Receptors, Glutamate; C004276:glutamylalanine; C094686:glutamyl-glutamic acid; D018698:Glutamic Acid; C045560:alanylglutamic acid; D016318:Quisqualic Acid
Vzaimodeĭstvie L-glutaminovoĭ kisloty s T-limfotsitami cheloveka.