The construction of metal centers in proteins by rational design.
Metalloprotein properties result from the interplay between coordination requirements of the metal center, protein stability, and modulation of the metal center by the surrounding protein matrix. Simple metal centers, which exercise control over the protein by affecting stability or enzyme activity, have been created by rational design. Complex centers, which require control by the protein matrix, have also been constructed.
Hellinga
H W
HW
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA. hellinga@linnaeus.biochem.duke.edu
D002118:Calcium / Q000737:chemistry; D004798:Enzymes / Q000737:chemistry; D006418:Heme / Q000737:chemistry; D006639:Histidine / Q000737:chemistry; D007506:Iron-Sulfur Proteins / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
D004798:Enzymes; D007506:Iron-Sulfur Proteins; D008670:Metals; D011506:Proteins; D006418:Heme; D006639:Histidine; D002118:Calcium