title: The pre-UV nutritional stresses increase UV resistance, decrease UV mutagenesis and inhibit excision repair.
abstract: Nutritional stresses applied to E. coli prior to UV irradiation increase UV resistance and decrease UV mutagenesis. This effect is uvrA-dependent and might reflect a more efficient excision of pyrimidine dimers [1]. The data presented here, however, indicate that after prestarvation for glucose or amino acids pyrimidine dimer excision (PDE) was partly inhibited. It appears that the stress conditions stimulate a mode of uvr-dependent tolerance of lesions, efficient and precise. Possible modes of PDE inhibition and lesion tolerance are discussed.
authors.affiliation: Department of Molecular Genetics, Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic.
authors.forename: V
authors.initials: V
authors.lastname: Slezarikova
authors.forename: F
authors.initials: F
authors.lastname: Masek
authors.forename: M
authors.initials: M
authors.lastname: Pirsel
authors.forename: M
authors.initials: M
authors.lastname: Sedliakova
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism; D002854:Chromatography, Paper; D004260:DNA Repair; D004269:DNA, Bacterial / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004720:Endonucleases / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects*; D029968:Escherichia coli Proteins; D005947:Glucose / Q000378:metabolism*; D016296:Mutagenesis / Q000528:radiation effects*; D013941:Thymine / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D004720:Endonucleases; C068631:UvrA protein, E coli; D000251:Adenosine Triphosphatases; D005947:Glucose; D013941:Thymine