Activated protein C resistance in patients with central retinal vein occlusion.
OBJECTIVE
A new defect in the anticoagulant system has recently been discovered--activated protein C resistance. The frequency of this disorder has been shown to be increased in young patients (< 50 years of age) with central retinal vein occlusion. This study was carried out to determine if there was any overrepresentation of activated protein C resistance in patients > 50 years of age with central retinal vein occlusion.


METHODS
Blood samples were obtained from 83 patients > 50 years of age and with a history of central retinal vein occlusion. The blood samples were analysed for activated protein C resistance with standard clinical laboratory methods.


RESULTS
In this material 11% of the patients were resistant to activated protein C. The normal incidence of activated protein C resistance in the same geographical area is 10-11%.


CONCLUSIONS
Activated protein C resistance does not seem to be a cause of central retinal vein occlusion in people older than 50 years.
Larsson
J
J
Department of Ophthalmology, Lund University Hospital, Sweden.
Sellman
A
A
Bauer
B
B
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011486:Protein C / Q000378:metabolism*; D012170:Retinal Vein Occlusion / Q000097:blood* / Q000235:genetics
D011486:Protein C