title: Psychiatric disorders in Wolfram syndrome heterozygotes.
abstract: Wolfram syndrome is an autosomal recessive disorder caused by a gene on the short arm of chromosome 4 and characterized by a range of neurological, psychiatric and behavioural abnormalities. Recent research suggests that heterozygous carriers of the disease gene are at increased risk of psychiatric hospitalization.
authors.forename: M J
authors.initials: MJ
authors.lastname: Owen
mesh_terms: D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D005808:Genes, Recessive; D006579:Heterozygote; D006801:Humans; D001523:Mental Disorders / Q000209:etiology / Q000235:genetics*; D010641:Phenotype; D014929:Wolfram Syndrome / Q000235:genetics* / Q000523:psychology*