title: Multiple cavernous angiomas after high-dose whole-brain radiation therapy.
abstract: Modern neuroimaging techniques have led to increased identification of angiographically occult cerebral angiomatous malformations. Cavernous angiomas or cavernomas account for approximately 16% of all cerebrovascular malformations. Little is reported about the etiology or risk for acquiring these lesions. This report suggests a possible association between acquired intracranial vascular malformations and long-term survivors after craniospinal external beam radiation therapy indicating that greater understanding of the cerebral vascular system's response to injury may provide insight into the evolution and progression of these lesions.
authors.affiliation: Section of Pediatric Neurosurgery, Allegheny University of the Health Sciences, Pittsburgh, Pa, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Novelli
authors.forename: D H
authors.initials: DH
authors.lastname: Reigel
authors.forename: P
authors.initials: P
authors.lastname: Langham Gleason
authors.forename: E
authors.initials: E
authors.lastname: Yunis
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000532:radiotherapy*; D002528:Cerebellar Neoplasms / Q000532:radiotherapy*; D002552:Cerebral Ventricles; D002675:Child, Preschool; D016371:Cranial Irradiation / Q000009:adverse effects; D004806:Ependymoma / Q000532:radiotherapy*; D006392:Hemangioma, Cavernous / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy*; D008833:Microcirculation / Q000528:radiation effects; D009381:Neoplasms, Radiation-Induced; D016609:Neoplasms, Second Primary; D010296:Parietal Lobe; D017741:Survivors; D013702:Temporal Lobe