Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients.
Down's syndrome (DS) cases from 1-40 years of age and showing no other anomalies or deficiencies were categorized into three age groups: group 1, < or = 12 years; group 2, 13-25 years; and group 3, > or = 26 years. The DNA-repair markers like unscheduled DNA synthesis (UDS), activities of DNA polymerases, (Total, beta and epsilon) and two endodeoxyribonucleases, (UV- and AP-DNases) were assessed in the peripheral lymphocytes of these subjects (under different conditions) along with age and sex matched normal healthy human subjects. The DS group showed lower DNA-repair efficiency and also an accelerated decline in DNA-repair capacity with age. These results indicate that deteriorated DNA-repair potential could be one of the probable reasons for premature aging seen in this chromosomal disorder.
Raji
N S
NS
Department of Biochemistry, School of Life Sciences, University of Hyderabad, India.
Rao
K S
KS
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism*; D019757:Carbon-Oxygen Lyases / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D043223:Deoxyribonuclease IV (Phage T4-Induced); D004314:Down Syndrome / Q000378:metabolism*; D004706:Endodeoxyribonucleases / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism; D009699:N-Glycosyl Hydrolases / Q000378:metabolism
D009097:Multienzyme Complexes; C032219:UV endonuclease; D004247:DNA; D004259:DNA-Directed DNA Polymerase; D004706:Endodeoxyribonucleases; D043223:Deoxyribonuclease IV (Phage T4-Induced); D009699:N-Glycosyl Hydrolases; D019757:Carbon-Oxygen Lyases; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase