title: Hyalinizing trabecular carcinoma of the thyroid gland: report of two cases of follicular cell thyroid carcinoma with hyalinizing trabecular pattern.
abstract: Recently tumors have been reported that have an architectural pattern and cellularity similar to hyalinizing trabecular adenoma and show either parafollicular differentiation or histological findings suggestive of malignant neoplasm of the follicular cells. This study describes two cases of thyroid carcinoma of follicular cells that displayed a hylinizing trabecular pattern. The first case was a 25-year-old euthyroid woman with a cold thyroid nodule in the right lobe. On fine needle aspiration a diagnosis of papillary carcinoma was rendered. The thyroidectomy disclosed a 2-cm, firm, brown, encapsulated tumor in the right lobe. The tumor had a growth pattern and cytologic features similar to those described in hyalinizing trabecular adenoma. The differences between these neoplasms were the presence of mitotic figures, prominence of the nucleolus, capsular blood vessel invasion, and microtubule groups in the endoplasmic reticulum. The second case was a 19-year-old euthyroid woman with a cold thyroid nodule in the left lobe. A cytologic diagnosis of follicular proliferation was rendered. A 4-cm, firm, whitish, encapsulated nodule was found in the left lobectomy. The tumor cells were arranged in two clear-cut patterns: a trabecular hyalinizing pattern with a small focus of papillary growth, and a follicular pattern. These findings confirm the existence of malignant thyroid tumors with a hyalinizing trabecular pattern and illustrate the nonspecificity of this peculiar pattern, since it may also be seen in papillary carcinomas of the thyroid. The relationship between hyalinizing trabecular adenoma and papillary carcinoma of the thyroid is commented on.
authors.affiliation: Hospital Universitario Virgen Macarena, University of Seville, Spain.
authors.forename: R
authors.initials: R
authors.lastname: González-Cámpora
authors.forename: E
authors.initials: E
authors.lastname: Fuentes-Vaamonde
authors.forename: A
authors.initials: A
authors.lastname: Hevia-Vázquez
authors.forename: C
authors.initials: C
authors.lastname: Otal-Salaverri
authors.forename: J L
authors.initials: JL
authors.lastname: Villar-Rodriguez
authors.forename: H
authors.initials: H
authors.lastname: Galera-Davidson
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000648:ultrastructure