Serum amyloid A and P protein levels are lowered by dextran sulfate cellulose low-density lipoprotein apheresis.
The present study describes the short-term effect of dextran sulfate cellulose (DSC) low-density lipoprotein (LDL) apheresis using a plasma separator equipped with a polysulfone (PS) membrane filter (PS/DSC-LDL apheresis) on the serum amyloid A (SAA) and P (SAP) protein levels during treatment in a patient with familial hypercholesterolemia (type IIa, heterozygote). PS/DSC-LDL apheresis markedly lowered both the SAA (reduction percentage, 84.1+/-8.2%) and SAP (91.4+/-5%) levels, which returned to their respective initial levels within 4 days. Experimentally, the levels of both proteins also decreased on passage through the DSC minicolumn without a PS membrane, indicating that the DSC resin had an affinity to both proteins. These results suggest that PS/DSC-LDL apheresis may be advantageous for amyloid protein accumulating disorders, including amyloidosis and atherosclerosis.
Yoshidome
H
H
The Third Department of Internal Medicine, Kagoshima University School of Medicine, Sakuragaoka, Japan.
Kuriyama
M
M
Fujiyama
J
J
Osame
M
M
D000328:Adult; D001781:Blood Component Removal; D001798:Blood Proteins / Q000032:analysis; D002482:Cellulose / Q000097:blood / Q000737:chemistry*; D016264:Dextran Sulfate / Q000097:blood / Q000737:chemistry*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000628:therapy; D008077:Lipoproteins, LDL / Q000097:blood / Q000302:isolation & purification*; D008567:Membranes, Artificial; D011108:Polymers / Q000737:chemistry; D000685:Serum Amyloid A Protein / Q000032:analysis / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000032:analysis / Q000378:metabolism*; D013450:Sulfones / Q000737:chemistry
D001798:Blood Proteins; D008077:Lipoproteins, LDL; D008567:Membranes, Artificial; D011108:Polymers; D000685:Serum Amyloid A Protein; D000683:Serum Amyloid P-Component; D013450:Sulfones; C017662:polysulfone P 1700; D002482:Cellulose; D016264:Dextran Sulfate