Protein aggregation: folding aggregates, inclusion bodies and amyloid.
Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding aggregates. Substantial data support the hypothesis that partially folded intermediates are key precursors to aggregates, that aggregation involves specific intermolecular interactions and that most aggregates involve beta sheets.
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Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064, USA. enzyme@cats.ucsc.edu
D000682:Amyloid / Q000737:chemistry*; D006801:Humans; D002479:Inclusion Bodies / Q000737:chemistry*; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
D000682:Amyloid; D011506:Proteins