Genetic manipulation of antibiotic-producing Streptomyces.
The genetic manipulation of Streptomyces species has been facilitated by the development of versatile cloning vectors, robust gene transfer systems and transposable elements. These molecular genetic tools have been used to construct antibiotic-producing strains with improved properties and recombinants for the production of hybrid glycopeptide and macrolide antibiotics, novel anthelminthic agents and novel cytotoxic anthracyclines.
Baltz
R H
RH
DowElanco, Indianapolis, IN 46268, USA. rbaltz@dowelanco.com
D000871:Anthelmintics / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis; D018014:Gene Transfer Techniques; D005818:Genetic Engineering / Q000379:methods; D005822:Genetic Vectors; D006020:Glycopeptides; D018942:Macrolides; D013302:Streptomyces / Q000235:genetics*
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D006020:Glycopeptides; D018942:Macrolides