title: Effect of supplemental gases on end-tidal CO2 and oxygen saturation in patients undergoing fentanyl and midazolam outpatient sedation.
abstract: Forty-six American Society of Anesthesiologists Class I and II adults were randomly assigned to one to two study groups. Each subject received 0.7 microgram/kg of fentanyl and a titrated dose of midazolam. One group received 100% supplemental oxygen (O2) while another group received 50% nitrous oxide (N2O) and 50% O2. End-tidal carbon dioxide (EtCO2) and O2 saturation (SpO2) were measured at 5-min intervals throughout the procedure. We conclude that there was no significant difference in EtCO2 or O2 saturation between the two groups.
authors.affiliation: Montefiore Medical Center, Bronx, New York 10467, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Rubin
authors.forename: S
authors.initials: S
authors.lastname: Eisig
authors.forename: K
authors.initials: K
authors.lastname: Freeman
authors.forename: R A
authors.initials: RA
authors.lastname: Kraut
mesh_terms: D000328:Adult; D000556:Ambulatory Surgical Procedures; D000701:Analgesics, Opioid; D002245:Carbon Dioxide / Q000502:physiology*; D016292:Procedural Sedation / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl; D006801:Humans; D006993:Hypnotics and Sedatives; D008874:Midazolam; D009609:Nitrous Oxide / Q000627:therapeutic use*; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use*; D013990:Tidal Volume / Q000187:drug effects*; D014081:Tooth Extraction
chemical_list: D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D002245:Carbon Dioxide; D009609:Nitrous Oxide; D008874:Midazolam; D010100:Oxygen; D005283:Fentanyl