title: Criteria for evaluating protein structures derived from comparative modeling.
abstract: Following the first experiment for the Critical Assessment of methods for protein Structure Prediction (CASP1), numerical criteria were devised to analyze the performance of prediction methods. We report here the criteria for comparative modeling, and how effective they were in CASP2. These criteria are intended to evolve into a set of numerical measures that provide a comprehensive assessment of the quality of a structure produced by comparative modeling, and provide a means of investigating which modeling methods are most effective, so as to establish where future effort may be most productively applied.
authors.affiliation: Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California, USA.
authors.forename: C
authors.initials: C
authors.lastname: Venclovas
authors.forename: A
authors.initials: A
authors.lastname: Zemla
authors.forename: K
authors.initials: K
authors.lastname: Fidelis
authors.forename: J
authors.initials: J
authors.lastname: Moult
mesh_terms: D005069:Evaluation Studies as Topic; D008958:Models, Molecular; D011487:Protein Conformation; D015203:Reproducibility of Results; D012107:Research Design; D016415:Sequence Alignment