Cardiomyopathy in a case of Crow-Fukase syndrome.
Crow-Fukase syndrome or POEMS syndrome is a variant of plasma cell dyscrasia that is characterized by polyneuropathy, organomegaly, endocrinopathy, the presence of M-protein in serum, and dermatological changes. A 60-year-old man presented with features of Crow-Fukase syndrome, such as the presence of M-protein in serum, dermatological changes, and osteosclerotic changes, but did not have polyneuropathy. To our knowledge, this is the first case of Crow-Fukase syndrome in which the presence of hypertrophic cardiomyopathy has been confirmed by a left endomyocardial biopsy. The findings suggest that hypertrophic cardiomyopathy may be a manifestation of organomegaly in patients with Crow-Fukase syndrome.
Shimizu
N
N
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Goya
M
M
Akimoto
H
H
Koike
A
A
Nogami
A
A
Ito
H
H
Marumo
F
F
Hiroe
M
M
D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology*; D064211:Connectin; D006801:Humans; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins; D009194:Myeloma Proteins / Q000032:analysis; D016878:POEMS Syndrome / Q000097:blood / Q000150:complications*
D064211:Connectin; D009124:Muscle Proteins; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins