title: Parenteral nutrition facilitates activation of coagulation but not of fibrinolysis during human endotoxemia.
abstract: Venous thrombosis and bacterial infections are common complications of parenteral nutrition. To test the hypothesis that infection facilitates activation of coagulation during parenteral nutrition, healthy subjects were intravenously injected with endotoxin (2 ng/kg) after they had received either 1 week of standard parenteral nutrition (n = 7) or normal enteral feeding (n = 8). Compared with enteral feeding, parenteral nutrition was associated with a selectively enhanced activation of the coagulation system (plasma levels of thrombin-antithrombin III complexes) during endotoxemia. Activation of the fibrinolytic system (plasminogen activator activity, tissue-type plasminogen activator, plasminogen activator inhibitor type 1) proceeded similarly in both study groups. In patients receiving parenteral nutrition, one common complication (bacterial infection) may facilitate the occurrence of another common complication (venous thrombosis) by synergistic stimulation of the coagulation system.
authors.affiliation: Cornell University Medical College, Laboratory of Surgical Metabolism, New York, New York, USA.
authors.forename: T
authors.initials: T
authors.lastname: van der Poll
authors.forename: M
authors.initials: M
authors.lastname: Levi
authors.forename: C C
authors.initials: CC
authors.lastname: Braxton
authors.forename: S M
authors.initials: SM
authors.lastname: Coyle
authors.forename: M
authors.initials: M
authors.lastname: Roth
authors.forename: J W
authors.initials: JW
authors.lastname: ten Cate
authors.forename: S F
authors.initials: SF
authors.lastname: Lowry
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D019446:Endotoxemia / Q000150:complications*; D004731:Endotoxins; D004750:Enteral Nutrition; D004926:Escherichia coli; D006801:Humans; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D013924:Thrombophlebitis / Q000150:complications*
chemical_list: D004731:Endotoxins; C044101:endotoxin, Escherichia coli