MS-681a, b, c and d, new inhibitors of myosin light chain kinase from Myrothecium sp. II. Physico-chemical properties and structure elucidation.
MS-681a, b, c and d are new inhibitors of myosin light chain kinase produced by Myrothecium sp. They are novel octapeptides containing alpha-alkyl-alpha-amino acids and a polyamine moiety. The structures were determined by NMR and FAB-MS/MS spectral analyses of the intact peptides. Their absolute configurations were elucidated by GC analysis on a chiral column of the constituent amino acids and by chemical synthesis of the polyamine moieties.
Ikuina
Y
Y
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Bando
C
C
Yoshida
M
M
Yano
H
H
Saitoh
Y
Y
D004791:Enzyme Inhibitors / Q000737:chemistry*; D006999:Hypocreales / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009219:Myosin-Light-Chain Kinase / Q000037:antagonists & inhibitors*; D010455:Peptides / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D013095:Spermidine / Q000737:chemistry
D004791:Enzyme Inhibitors; D010455:Peptides; D011073:Polyamines; D009219:Myosin-Light-Chain Kinase; D013095:Spermidine