[Changes in the kinetics of the hemoglobin, total protein and DNA content in rat erythroid cells in experimental anemia. I. The peripheral blood].
Cytophotometry of rat blood erythroid cells during anaemia, induced by phenylhydrazin (4-8 days from the beginning of injections), revealed that all forms of bone marrow containing haemoglobin were thrown into the blood. On its peak (4th day), the greatest contribution in blood haemoglobinization (50%) is made by microcytes. From the 5th day and up to the end of the restoration period the important role in this process is played by macrocytes. From the 6th day the role of normocytes increases, whose contribution by 8th day reaches 70% of the whole haemoglobin amount in blood. In contrary to anaemizated birds, whose erythroid cells ripen in blood, in rats all the transformations of erythron during anaemia are accomplished in bone marrow.
Magakian
Iu A
IuA
Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, Yerevan.
Karalova
E M
EM
Abroian
L O
LO
Karapetian
S A
SA
D000208:Acute Disease; D000740:Anemia / Q000097:blood* / Q000139:chemically induced; D000818:Animals; D001798:Blood Proteins / Q000032:analysis* / Q000187:drug effects; D003592:Cytophotometry; D004247:DNA / Q000097:blood* / Q000187:drug effects; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000378:metabolism*; D006454:Hemoglobins / Q000032:analysis* / Q000187:drug effects; D007700:Kinetics; D010659:Phenylhydrazines; D051381:Rats; D013997:Time Factors
D001798:Blood Proteins; D006454:Hemoglobins; D010659:Phenylhydrazines; C030299:phenylhydrazine; D004247:DNA
Izmeneniia v kinetike soderzhaniia gemoglobina, summarnogo belka i DNK v éritroidnykh kletkak krys pri éksperimental'noĭ anemii. I. Perifericheskaia krov'.