title: Autoimmune thyrotoxicosis developed during growth hormone (GH) treatment of an adult with childhood onset GH-deficiency. A causal relationship?
abstract: Thyroid hyperfunction during growth hormone (GH) therapy has not been reported previously. We report a case of a 33-year-old female who developed autoimmune thyrotoxicosis during treatment with GH and with normalization of the thyroid function after discontinuation of GH therapy. After rechallenge with GH she again developed thyrotoxicosis, this time with presence of thyroid autoantibodies and without normalization of the thyroid function after stopping the GH treatment. Several possibilities for a causal relationship between GH therapy and development of autoimmune thyrotoxicosis are proposed.
authors.affiliation: Department of Medical Endocrinology, National University Hospital, Copenhagen University, Denmark.
authors.forename: A K
authors.initials: AK
authors.lastname: Rasmussen
authors.forename: U
authors.initials: U
authors.lastname: Feldt-Rasmussen
authors.forename: N E
authors.initials: NE
authors.lastname: Skakkebaek
authors.forename: J O
authors.initials: JO
authors.lastname: Jørgensen
authors.forename: J S
authors.initials: JS
authors.lastname: Christiansen
authors.forename: J
authors.initials: J
authors.lastname: Müller
mesh_terms: D000328:Adult; D017668:Age of Onset; D001327:Autoimmune Diseases / Q000139:chemically induced*; D005260:Female; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D013961:Thyroid Gland / Q000187:drug effects / Q000276:immunology; D013971:Thyrotoxicosis / Q000139:chemically induced*
chemical_list: D019382:Human Growth Hormone