A rhino mutant originating in KK mice.
In 1991, several hairless offspring were found in our black haired KK (KK-C) mouse colony. This mutant, provisionally naming KK-rhino mouse was clinicopathologically and histopathologically investigated in a chronological manner. KK-rhino has a hairless trait and wrinkled and pimpled skin, which resemble the characteristics of the so-called rhino mouse. It was presumed from a preliminary mating examination that the trait of the KK-rhino mutant might be manifested by the [hrrh] gene. Other properties of this mutant might be inherited from the maternal KK-C line. KK-rhino mouse is a unique mouse strain which has two quite different traits, "rhino" and "diabetes".
Kume
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E
Lead Optimization Research Laboratory, Tanabe Seiyaku Co. Ltd., Saitama, Japan.
Yamada
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T
Iwasaki
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H
D000818:Animals; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000235:genetics; D001947:Breeding; D005260:Female; D008136:Longevity; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D008813:Mice, Inbred ICR; D008817:Mice, Mutant Strains / Q000033:anatomy & histology / Q000097:blood / Q000235:genetics / Q000502:physiology