[Paroxysmal activity test in pediatric neurology].
Taking into consideration the significance of glutamate receptors in epileptic focus forming, the authors studied the level of autoantibodies (Glu aAB) to fragment of glutamate receptors, quisqualate membrane protein with molecular mass 56 kDa in blood serum. The study employed the diagnostic kit "Paroxysmal activity test" (PAT) elaborated in Institute of Human Brain, RAS (St-Petersburg), 140 children from 2 months to 16 years with epilepsy, epileptic syndrome, paroxysmal states of nonepileptic genesis and with other neurologic diseases as well as 32 practically healthy children were examined. Significant increase of Glu aAB level was found in children with epilepsy and epileptic syndrome as compared with healthy children. Glu aAB level was decreased in patients which were treated by adequate anticonvulsant therapy that resulted in relief of convulsive fits for 6 months and normalization of EEG. In patients with paroxysmal disorders Glu aAB content was lower than in patients with epilepsy and epileptic syndrome, but higher than in healthy children; 5 children from this group with high level of Glu aAB had seizures in aged. It was proposed to introduce the described method into clinic for the study of the processes of brain's epileptization in process of development of diseases of nervous system, accompanied by convulsions or paroxysmal states.
Maslova
O I
OI
Globa
O V
OV
Sorokina
E G
EG
Pinelis
V G
VG
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis*; D001921:Brain / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007223:Infant; D017470:Receptors, Glutamate / Q000276:immunology* / Q000502:physiology; D012640:Seizures / Q000503:physiopathology
D000927:Anticonvulsants; D001323:Autoantibodies; D017470:Receptors, Glutamate
"Test paroksizmal'noĭ aktivnosti" v detskoĭ nevrologii.