Granulocyte-macrophage colony-stimulating factor-associated histiocytosis and capillary-leak syndrome following autologous bone marrow transplantation: two case reports and a review of the literature.
Bone marrow (BM) histiocystosis in association with the administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) is a rare phenomenon with few published cases. We report two cases of BM histiocystosis in patients with Hodgkin's disease treated with GM-CSF after autologous bone marrow transplantation. Both patients also developed clinical features of capillary leak syndrome, another rare complication of GM-CSF administration. GM-CSF-induced histiocystosis should now be considered in the differential diagnosis of delayed engraftment post-autotransplant.
Al-Homaidhi
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University of Toronto Autologous Blood and Marrow Transplant Program, The Toronto Hospital, Ontario, Canada.
Prince
H M
HM
Al-Zahrani
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Doucette
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Keating
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D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D019559:Capillary Leak Syndrome / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000009:adverse effects*; D015614:Histiocytosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology; D008297:Male; D014182:Transplantation, Autologous
D016178:Granulocyte-Macrophage Colony-Stimulating Factor