title: Optical biopsy with optical coherence tomography.
abstract: A need exists in medicine for a technology capable of 'optical biopsy,' imaging at or near the resolution of histopathology without the need for excisional biopsy. Optical coherence tomography (OCT) is a recently developed imaging technology that uses infrared light to generate cross-sectional images on a micron scale. In this work, the feasibility of OCT for optical biopsy was confirmed with in vitro tissue from the skeletal and male reproductive systems. This work supports the hypothesis that OCT is an attractive technology for in vivo optical biopsy.
authors.affiliation: Cardiac Unit, Massachusetts General Hospital, Boston 02114, USA. mebrezin@mit.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Brezinski
authors.forename: G J
authors.initials: GJ
authors.lastname: Tearney
authors.forename: B
authors.initials: B
authors.lastname: Bouma
authors.forename: S A
authors.initials: SA
authors.lastname: Boppart
authors.forename: C
authors.initials: C
authors.lastname: Pitris
authors.forename: J F
authors.initials: JF
authors.lastname: Southern
authors.forename: J G
authors.initials: JG
authors.lastname: Fujimoto
mesh_terms: D001706:Biopsy / Q000379:methods*; D001842:Bone and Bones / Q000473:pathology; D006801:Humans; D008297:Male; D013737:Testis / Q000473:pathology; D014054:Tomography