[Lethal infection of newborn mice, caused by hepatitis C virus].
Intracerebral infection of mice aged 2-3 days with hepatitis C virus (HCV) from chronically infected suckling mouse brain cultures and porcine embryo cells resulted in the death of animals after 12-14 days. Repeated passages of HCV in animals decreased the incubation period to just 3-4 days. Blood serum of surviving mice collected during the 4th week postinfection contained antiHCV antibodies detected by enzyme immunoassay and hemagglutination inhibition test. The results are proof of creation of a new in vivo model of experimental HCV infection.
Deriabin
P G
PG
Isaeva
E I
EI
Viazov
S O
SO
L'vov
D K
DK
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001921:Brain / Q000821:virology; D002417:Cattle; D046508:Culture Techniques; D006386:Hemagglutination Tests; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D006526:Hepatitis C / Q000503:physiopathology*; D018937:Hepatitis C Antibodies / Q000097:blood; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000166:cytology / Q000196:embryology / Q000821:virology; D051379:Mice; D012692:Serial Passage
D018937:Hepatitis C Antibodies
Letal'naia infektsiia novorozhdennykh mysheĭ, vyzvannaia virusom gepatita C.