Myocardial effects of isoflurane in healthy infants and small children. Assessment by continuous oesophageal aortic blood flow echo-Doppler.
BACKGROUND
In paediatric healthy patients and in real peroperative conditions, the cardiovascular effects of isoflurane have been poorly described.


METHODS
We have evaluated the myocardial effects of 1% end-expired concentration (EEC) of isoflurane in 25 healthy infants or small children undergoing superficial surgical therapy for small burns with a continuous aortic blood flow echo-Doppler device. Aortic blood flow (ABF) was measured with a small oesophageal probe specially designed for infants. The aortic flowmeter was connected with satellite devices to visualize the haemodynamic profile variations during the isoflurane inhalation period.


RESULTS
Isoflurane significantly decreased ABF and increased pre-ejection period/left ventricular ejection time (PEP/LVET), when compared with control values previously recorded 5 min after induction with halothane-fentanyl and atracurium (respectively, 80 +/- 7%, mean +/- SD; P < 0.001 and 111 +/- 11%; P = 0.017, 5 min after EEC of isoflurane reached 1%, then respectively, 75 +/- 12%; P < 0.001 and 119 +/- 16%; P < 0.001, at the end of the isoflurane inhalation period). These variations reversed to a great extent when isoflurane was switched off (97 +/- 17% for ABF; P = 0.08 and 105 +/- 12% for PEP/LVET; P = 0.75). Among the usual parameters, 1% EEC of isoflurane caused no significant changes in heart rate, moderately decreased mean arterial pressure (successively, 88 +/- 12%; P = 0.045 and 87 +/- 19%; P = 0.049), but belatedly decreased end-tidal CO2 pressure (87 +/- 11% at the end of the inhalation period (P < 0.001) which persisted 5 min after isoflurane was turned off (90 +/- 11%; P < 0.001)).


CONCLUSIONS
These findings suggest that isoflurane can transiently depress cardiac function in healthy infants.
Gueugniaud
P Y
PY
Department of Anaesthesia, Burn Centre, Claude Bernard University, Edouard Herriot Hospital, Lyon, France.
Bertin-Maghit
M
M
Abisseror
M
M
Branche
P
P
Piriou
V
V
Bouchard
C
C
Petit
P
P
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D002675:Child, Preschool; D004947:Esophagus / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007223:Infant; D007530:Isoflurane / Q000494:pharmacology*; D017078:Laser-Doppler Flowmetry; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects
D018685:Anesthetics, Inhalation; D007530:Isoflurane