title: Synthesis of 5-membered ring-type compounds as potential cholecystokinin receptor ligands.
abstract: Imidazolidine-2,4-diones and 1,5-diphenyl tetramic acid derivatives were selected in order to evaluate some 5-membered heterocyclic ring compounds as potential templates for the synthesis of CCK receptor ligands. All the compounds were evaluated in vitro towards both CCK-B and CCK-A receptors.
authors.affiliation: Glaxo Wellcome S.p.A., Medicines Research Centre, Verona, Italy. GGP7108@ggr.co.uk
authors.forename: G
authors.initials: G
authors.lastname: Pentassuglia
authors.forename: G L
authors.initials: GL
authors.lastname: Araldi
authors.forename: D
authors.initials: D
authors.lastname: Donati
authors.forename: A
authors.initials: A
authors.lastname: Feriani
authors.forename: B
authors.initials: B
authors.lastname: Oliosi
authors.forename: A
authors.initials: A
authors.lastname: Pasquarello
authors.forename: A
authors.initials: A
authors.lastname: Ursini
mesh_terms: D002478:Cells, Cultured; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D008566:Membranes / Q000378:metabolism; D008958:Models, Molecular; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D011869:Radioligand Assay; D011949:Receptors, Cholecystokinin / Q000187:drug effects*
chemical_list: D007093:Imidazoles; D008024:Ligands; D011760:Pyrrolidinones; D011949:Receptors, Cholecystokinin; C009435:tetramic acid