DNA as a vehicle for the self-assembly model of computing.
A DNA version of the self-assembly model of computing, feasible using currently available laboratory techniques, is proposed. Input signals are coded into unmethylated and methylated oligonucleotides which then hybridize with a backbone that contains complementary sequences. Different input signal patterns are thus represented as DNA duplexes with distinctly different conformational dynamics, in particular different equilibria of B and Z DNA. The pattern classification activity of the system is mediated by the interactions that lead to the secondary structural organization. Circular dichroism may be used for readout.
Conrad
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M
Department of Computer Science, Wayne State University, Detroit, MI 48202, USA. biocomputing@cs.wayne.edu
Zauner
K P
KP
D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry; D012313:RNA / Q000737:chemistry
D011506:Proteins; D012313:RNA; D004247:DNA