Atorvastatin does not alter the anticoagulant activity of warfarin.
Twelve patients chronically maintained on warfarin were administered 80 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slightly, but only for the first few days of the two-week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activity of warfarin and adjustment in warfarin dosing should not be necessary.
Stern
R
R
Department of Clinical Pharmacology, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan, USA.
Abel
R
R
Gibson
G L
GL
Besserer
J
J
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D000069059:Atorvastatin; D001777:Blood Coagulation / Q000187:drug effects*; D004347:Drug Interactions; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011516:Prothrombin / Q000187:drug effects*; D011517:Prothrombin Time; D011758:Pyrroles / Q000008:administration & dosage / Q000494:pharmacology*; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D014859:Warfarin; D011516:Prothrombin; D000069059:Atorvastatin