title: Fatal Staphylococcus aureus infective endocarditis: the dental implications.
abstract: Infective endocarditis remains an important and life-threatening infection despite improvements in diagnosis and management. There is currently a greater role for nosocomial acquisition of organisms and immunosuppression in the pathogenesis of this disease and emergence of a broader spectrum of infective organisms including those not commonly isolated from the mouth such as staphylococci. We report a case of infective endocarditis caused by Staphylococcus aureus in which the patient developed disseminated intravascular coagulation and multiple septic infarcts resulting in a frontal lobe brain abscess. Multiple dental extractions were complicated by delayed postextraction hemorrhage and the immediate cause of death was abdominal hemorrhage. The dental management in infective endocarditis should be planned in consultation with the attending physician, and should take into account both the causative organism and the presence of complications. When the oral cavity cannot be proven as the bacterial source for infective endocarditis, the immediate dental management should be directed toward improving the patient's oral hygiene and providing pain relief. Definitive long-term treatment, including any extractions, is ideally delayed until the patient has fully recovered from the infective endocarditis and its attendant complications.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Westmead Hospital Dental Clinical School, NSW, Australia.
authors.forename: O J
authors.initials: OJ
authors.lastname: Younessi
authors.forename: D M
authors.initials: DM
authors.lastname: Walker
authors.forename: P
authors.initials: P
authors.lastname: Ellis
authors.forename: D E
authors.initials: DE
authors.lastname: Dwyer
mesh_terms: D001922:Brain Abscess / Q000209:etiology* / Q000382:microbiology; D017742:Dental Care for Chronically Ill / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000382:microbiology; D004697:Endocarditis, Bacterial / Q000150:complications / Q000382:microbiology*; D017809:Fatal Outcome; D005260:Female; D005491:Focal Infection, Dental / Q000382:microbiology*; D006465:Hemoperitoneum / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D006472:Oral Hemorrhage / Q000209:etiology; D013211:Staphylococcus aureus / Q000302:isolation & purification; D014081:Tooth Extraction / Q000009:adverse effects