Influence of intermittent fasting and high-fat diet on morphological changes of the digestive system and on changes of lipid metabolism in the laboratory mouse.
The simultaneous effect of intermittent starvation and a high-fat diet were investigated in mice after several weeks of experimental feeding. The animals adapted to intermittent fasting fed a high-fat diet showed a lower degree of hyperphagia than animals adapted to intermittent fasting fed a standard laboratory diet. The weight of both individual portions of the stomach was elevated in adapted animals fed both a standard laboratory diet and the high-fat diet. The weight of the small intestine was increased in adapted animals fed a high-fat diet. The length of the small intestine was not changed after 8 weeks of intermittent starvation in both adapted groups (standard laboratory diet, high-fat diet). A higher amount of body fat was found in both groups of animals adapted to intermittent fasting (standard laboratory diet, high-fat diet) but adapted animals fed a high-fat diet showed less body fat than adapted animals fed a standard laboratory diet. Lower levels of serum lipids were found in adapted animals fed a high-fat diet. These results suggest that both lipogenesis and lipid oxidation are accentuated by intermittent starvation and a high-fat diet act concomitantly.
Krízová
E
E
Department of Comparative Animal Physiology and General Zoology, Faculty of Science, Masaryk University, Brno, Kotlárská, Czech Republic.
Simek
V
V
D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D004064:Digestive System / Q000033:anatomy & histology* / Q000187:drug effects; D005215:Fasting / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D013270:Stomach / Q000033:anatomy & histology / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology
D004041:Dietary Fats; D008055:Lipids