title: [The prevention of reproductive disorders occurring during the chemotherapy of women of child-bearing age suffering from Hodgkin's disease].
abstract: A menstrual function was studied in 24 females treated by drugs for advanced stages of Hodgkin's disease. 17 of them received oral contraceptives for preventing gonadotoxic effect of cytostatic agents (the study group). 7 women did not use contraceptives (the control group). After chemotherapy menstrual cycle was normal in 88.2% of patients of the study group, whereas in 71.4% of controls artificial menopause developed. Oral contraceptives can be recommended to protect the ovaries in the course of chemotherapy.
authors.forename: E V
authors.initials: EV
authors.lastname: Ignashina
authors.forename: A V
authors.initials: AV
authors.lastname: Pivnik
authors.forename: D E
authors.initials: DE
authors.lastname: Shilin
authors.forename: O M
authors.initials: OM
authors.lastname: Nasibov
authors.forename: O V
authors.initials: OV
authors.lastname: Margolin
authors.forename: L A
authors.initials: LA
authors.lastname: Pustovoĭt
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage; D004347:Drug Interactions; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced / Q000517:prevention & control*; D008598:Menstruation / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects*
chemical_list: D003278:Contraceptives, Oral, Hormonal
vernacular_title: Profilaktika reproduktivnykh narusheniĭ, voznikaiushchikh v protsesse khimioterapii u zhenshchin detorodnogo vozrasta, stradaiushchikh bolezn'iu Khodzhkina.