Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E.
Feline immunodeficiency virus (FIV) is classified into five genotypes, A, B, C, D and E, based on the phylogenetic analysis of the env V3-V5 region. However, whether there is correlation between phylogenetic and antigenic diversities remains unknown. In this study, we examined the cross virus neutralization of FIV genotypes A through E by sera from cats infected with a single genotype. The results indicated some relationships between phylogenetic genotype and neutralization serotype, and that cross-clade virus neutralization is possible. For example, serum from a cat infected with genotype E virus neutralized all five FIV genotypes. Our results suggest that the FIV subtyping according to the sequence diversity is partially reflected by antigenic diversity and serum neutralization.
Inoshima
Y
Y
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan.
Miyazawa
T
T
Kohmoto
M
M
Ikeda
Y
Y
Sato
E
E
Hohdatsu
T
T
Mathiason-Dubard
C
C
Hoover
E A
EA
Mikami
T
T
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D002415:Cats; D003429:Cross Reactions / Q000276:immunology; D016181:Feline Acquired Immunodeficiency Syndrome / Q000097:blood / Q000145:classification / Q000276:immunology; D005838:Genotype; D016089:Immunodeficiency Virus, Feline / Q000145:classification / Q000235:genetics / Q000276:immunology*; D009500:Neutralization Tests; D012680:Sensitivity and Specificity
D000914:Antibodies, Viral