title: Role of hepatic arterial embolisation in the treatment for metastatic insulinoma. Report of two cases and review of the literature.
abstract: Malignant insulinomas are very rare. They have typical clinical and biochemical characteristics that allow an early detection and distinction from other sorts of islet cell carcinoma. As a result a curative resection can occasionally be managed. Nevertheless, for more advanced stages the same treatment options as for other metastatic neuroendocrine tumours must be considered: palliative surgery, medical treatment, chemotherapy and hepatic arterial (chemo-) embolisation. Especially the last kind of treatment has recently gained interest. We report two cases of metastatic insulinoma treated in this way. In the first case we are able to record an unusually long survival through the single use of sequential embolisation, following palliative resection of the primary tumour. In the second case we describe the current way to use this technique, i.e. in combination with chemotherapy. We argue that it might be more important in the treatment of metastatic insulinoma to combine hepatic arterial embolisation with other types of local or systemic therapy, rather than the choice of this most efficient technique on its own.
authors.affiliation: Department of Endocrinology, Algemeen Ziekenhuis Middelheim, Antwerp.
authors.forename: J
authors.initials: J
authors.lastname: Berwaerts
authors.forename: J
authors.initials: J
authors.lastname: Verhelst
authors.forename: H
authors.initials: H
authors.lastname: Hubens
authors.forename: J
authors.initials: J
authors.lastname: Kunnen
authors.forename: D
authors.initials: D
authors.lastname: Schrijvers
authors.forename: E
authors.initials: E
authors.lastname: Joosens
authors.forename: C
authors.initials: C
authors.lastname: Mahler
authors.forename: L
authors.initials: L
authors.lastname: Van Gaal
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007340:Insulinoma / Q000556:secondary*; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology*; D016896:Treatment Outcome