Effect of isoflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells.
Two dietary soybean isoflavones, genistein and daidzein, were studied for the inhibition of lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. The isoflavone genistein at 200 mumol/kg body wt significantly inhibited (53.6%, p < 0.001) lung tumor nodule formation. The lung collagen hydroxyproline content and the serum sialic acid level, a marker of metastasis, were also significantly lower in these animals than in untreated tumor-bearing animals. Genistein treatment also increased the life span of the tumor-bearing animals (47.7%, p < 0.001). The isoflavone daidzein had no significant effect on the reduction of lung metastasis induced by B16F-10 melanoma cells.
Menon
L G
LG
Amala Cancer Research Centre, Nagar, India.
Kuttan
R
R
Nair
M G
MG
Chang
Y C
YC
Kuttan
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor; D003094:Collagen / Q000032:analysis; D019833:Genistein / Q000627:therapeutic use*; D006909:Hydroxyproline / Q000032:analysis; D007529:Isoflavones / Q000627:therapeutic use*; D008168:Lung / Q000737:chemistry; D008175:Lung Neoplasms / Q000401:mortality / Q000517:prevention & control* / Q000556:secondary*; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D019158:N-Acetylneuraminic Acid / Q000097:blood; D015996:Survival Rate; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D007529:Isoflavones; C004742:daidzein; D003094:Collagen; D019833:Genistein; D019158:N-Acetylneuraminic Acid; D006909:Hydroxyproline