title: Effects of mastoid cavity obliteration on the growth of experimentally produced residual cholesteatoma.
abstract: The effects of obliteration of the mastoid cavity on the growth of residual cholesteatoma were histologically studied in an animal model. A dermal cyst was produced by grafting a piece of autologous auricular skin in the otic bulla of 11 guinea-pigs. Three weeks after grafting, part of the cyst wall facing the cavity was removed and the debris accumulated inside was inserted into the surrounding granulation using a micropick. This procedure simulates the growth mechanism of cholesteatoma residue which sometimes occurs after middle ear surgery in human subjects. In six animals, the bulla was then obliterated with plaster of Paris. The remaining five animals were used as controls. Animals were killed for histological study at 2, 4 or 8 weeks postoperatively. Microscopic examinations revealed that in the obliteration group, severe inflammatory reactions were induced in the otic bulla, although the graft epithelium survived there; dermal cyst reformed in only one of six animals. In the controls, cyst reformation was recognized in all animals. This indicated that severe inflammation induced by plaster prevented growth of the graft epithelium in the otic bulla.
authors.affiliation: Department of Otolaryngology, Ehime University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hinohira
authors.forename: K
authors.initials: K
authors.lastname: Gyo
authors.forename: N
authors.initials: N
authors.lastname: Yanagihara
authors.forename: G
authors.initials: G
authors.lastname: Bredberg
authors.forename: E
authors.initials: E
authors.lastname: Alsterborg
mesh_terms: D000818:Animals; D018424:Cholesteatoma, Middle Ear / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D015726:Giant Cells / Q000473:pathology; D006097:Granulation Tissue / Q000473:pathology; D006168:Guinea Pigs; D006801:Humans; D008416:Mastoid / Q000473:pathology / Q000601:surgery*; D012008:Recurrence