Myocardial damage during percutaneous transluminal coronary angioplasty as evidenced by troponin T measurements.
OBJECTIVE
The present study was undertaken to assess the effect of balloon inflation during percutaneous transluminal coronary angioplasty on markers of myocardial damage.


RESULTS
Seventy-five patients undergoing elective percutaneous transluminal coronary angioplasty were evaluated with serum creatine kinase MB and cardiospecific troponin T before and 1 and 4 days after the procedure. On day 1, 28% of the patients had increased cardiospecific troponin T values and 18% had increased creatine kinase MB values. On day 4, 24% had increased cardiospecific troponin T values, whereas all creatine kinase MB values were normal. A high degree of correlation between creatine kinase MB and cardiospecific troponin T on day 1, as well as between both markers on day 1 and cardiospecific troponin T on day 4 were found. The increased levels of cardiospecific troponin T on day 4 was significantly correlated with the total balloon inflation time (P < 0.001).


CONCLUSIONS
We conclude that irreversible myocardial damage, as evidenced by increased cardiospecific troponin T values on day 4, occurs in an appreciable number of patients during percutaneous transluminal coronary angioplasty, and that this damage is strongly correlated with the total balloon inflation time.
Johansen
O
O
Department of Cardiology, Ullevål University Hospital, Oslo, Norway.
Brekke
M
M
Strømme
J H
JH
Valen
V
V
Seljeflot
I
I
Skjaeggestad
O
O
Arnesen
H
H
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006335:Heart Injuries / Q000209:etiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014336:Troponin / Q000032:analysis*
D014336:Troponin; D003402:Creatine Kinase