title: A nosocomial cluster of Candida inconspicua infections in patients with hematological malignancies.
abstract: Candida inconspicua was recovered from three patients with hematological malignancies. Two patients had intravenous-catheter-associated fungemia, whereas the third had fungal hepatitis. The three cases of infection occurred over a period of 1 month in patients staying in adjacent single rooms. In vitro susceptibility testing of fungal strains showed all isolates to be resistant to fluconazole, with MICs greater than 32 microg/ml. All of the strains had identical DNA restriction profiles and randomly amplified polymorphic DNA fingerprints. These data suggest a nosocomially acquired infection emanating from a common source within the hospital environment.
authors.affiliation: Dipartimento di Ematologia ed Oncologia, Ospedale Santo Spirito, Pescara, Italy.
authors.forename: D
authors.initials: D
authors.lastname: D'Antonio
authors.forename: B
authors.initials: B
authors.lastname: Violante
authors.forename: A
authors.initials: A
authors.lastname: Mazzoni
authors.forename: T
authors.initials: T
authors.lastname: Bonfini
authors.forename: M A
authors.initials: MA
authors.lastname: Capuani
authors.forename: F
authors.initials: F
authors.lastname: D'Aloia
authors.forename: A
authors.initials: A
authors.lastname: Iacone
authors.forename: F
authors.initials: F
authors.lastname: Schioppa
authors.forename: F
authors.initials: F
authors.lastname: Romano
mesh_terms: D000328:Adult; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D016000:Cluster Analysis; D003428:Cross Infection / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D004196:Disease Outbreaks; D005260:Female; D016469:Fungemia / Q000382:microbiology; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D008224:Lymphoma, Follicular / Q000150:complications; D008297:Male; D008875:Middle Aged