t(3;17)(q21;q25) in Epstein-Barr virus associated peripheral T-cell lymphoma: a paediatric case.
We describe an immunocompetent 8-year-old boy with a serological profile indicating chronic infection by Epstein-Barr virus (EBV) who developed subcutaneous and pulmonary lesions related to a peripheral T-cell proliferation. No clonal rearrangement of T-cell receptor or immunoglobulin genes was seen. However, the finding of a t(3;17)(q21;q25) in 44 metaphases from one skin lesion demonstrated a clonal origin. We also showed that the proliferative T cells contained EBV genome leading to the diagnosis of EBV-associated peripheral T-cell lymphoma. Further cytogenetic and molecular studies are needed to identify genes implicated in the pathogenesis of this haematological malignancy.
Millot
F
F
Department of Clinical Haematology, Hospital Jean Bernard, Poitiers, France.
Brizard
F
F
Babin
P
P
Canioni
D
D
Macintyre
E
E
Levard
G
G
Gambert
C
C
Ricour
C
C
Guilhot
F
F
D002648:Child; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D004854:Herpesvirus 4, Human; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics* / Q000821:virology; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics* / Q000821:virology; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics* / Q000821:virology; D008297:Male; D012878:Skin Neoplasms / Q000235:genetics* / Q000821:virology; D014178:Translocation, Genetic; D014412:Tumor Virus Infections / Q000235:genetics*