title: Neuroradiologic findings in Marinesco-Sjögren syndrome.
abstract: OBJECTIVE
  Our purpose was to determine the neuroradiologic findings of Marinesco-Sjögren syndrome on plain skull radiographs, CT, and MR images.
  
  
  METHODS
  Eight patients with proved Marinesco-Sjögren syndrome (age range, 4 to 56 years) had a total of nine CT scans, seven MR imaging studies, and two plain radiographic examinations of the skull. The findings were reviewed retrospectively, with particular attention to the size of the posterior fossa and cerebellum.
  
  
  RESULTS
  All patients had hypoplastic cerebellar hemispheres and a hypoplastic vermis in a small posterior fossa. One patient had a midline posterior fossa cyst and another had agenesis of the corpus callosum.
  
  
  CONCLUSIONS
  Hypoplasia of the cerebellar hemispheres and the vermis and a small posterior fossa are the most prominent neuroradiologic findings in Marinesco-Sjögren syndrome.
authors.affiliation: Department of Radiology, University of South Alabama College of Medicine, Mobile, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Georgy
authors.forename: R D
authors.initials: RD
authors.lastname: Snow
authors.forename: B G
authors.initials: BG
authors.lastname: Brogdon
authors.forename: W
authors.initials: W
authors.lastname: Wertelecki
mesh_terms: D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum; D002531:Cerebellum / Q000002:abnormalities / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D003337:Corpus Callosum / Q000473:pathology; D003388:Cranial Fossa, Posterior / Q000473:pathology; D003560:Cysts / Q000175:diagnosis / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013132:Spinocerebellar Degenerations / Q000175:diagnosis* / Q000235:genetics; D014057:Tomography, X-Ray Computed