[Soluble TNF-alpha receptors].
Soluble cytokine receptors are more general phenomena and play a wider physiological role in the regulation of the immune system than previously recognized. Soluble TNF receptors--sTNF-Rp55 and sTNF-Rp75 by ability to bind to free TNF-alpha might play a regulatory role in a variety of normal and abnormal reactions mediated by TNF-alpha. Increase of sTNF-Rs levels have been observed in the serum of patients with a different diseases. Measurement of soluble TNF receptors concentrations seems to be a significant indicator in prognostic estimation of some diseases. Additionally, bioengineered soluble receptors may prove useful as specific cytokine-inhibiting therapeutic agents.
Jabłońska
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Zakład Immunopatologii Akademii Medycznej w Białymstoku.
D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism* / Q000627:therapeutic use; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D047889:Receptors, Tumor Necrosis Factor, Type II; D053319:Tumor Necrosis Factor Decoy Receptors
D009363:Neoplasm Proteins; D018124:Receptors, Tumor Necrosis Factor; D047889:Receptors, Tumor Necrosis Factor, Type II; D053319:Tumor Necrosis Factor Decoy Receptors
Rozpuszczalne receptory TNF-alpha.