title: [Collagenous colitis: presentation of 12 cases].
abstract: Collagenous colitis (CC) is a cause of chronic aqueous diarrhea with normal radiologic study and endoscopic appearance of the colonic mucosa. Histologically, it is defined by the presence of a thickened subepithelial collagenous band and inflammatory changes of the mucosa. The cause of CC is currently unknown, although several mechanisms have been proposed, such as an inflammatory, autoimmune, origin, disregulation in collagen synthesis, plasma vasculosis and a possible role of bacterial or drug toxins. The clinicopathological data of 12 patients (9 females and 3 males) with a mean age of 52.4 years diagnosed by histologic criteria are presented. Aqueous diarrhea was observed in all the patients with a mean number of 5.4 stools/day during a time period between 3 weeks and 10 years (mean, 14.7 months). In a 6 patients allergies and/or associated diseases, mainly rheumatologic diseases were found. Laboratory and endoscopic data were normal or unspecific, with colon biopsy being carried out in all the patients. Several treatments were tested with good response with sulphasalazine derivatives, corticoids, antibiotics, and mebeverine, with no solution to the diarrhea in 2 patients. A review of the literature is also provided.
authors.affiliation: Servicio de Patología Digestiva, Hospital General Universitario de Valencia.
authors.forename: P
authors.initials: P
authors.lastname: Rivera
authors.forename: S
authors.initials: S
authors.lastname: Pamos
authors.forename: J
authors.initials: J
authors.lastname: Cuquerella
authors.forename: L
authors.initials: L
authors.lastname: Ferrer
authors.forename: A
authors.initials: A
authors.lastname: Tomé
authors.forename: E
authors.initials: E
authors.lastname: Ortí
authors.forename: I
authors.initials: I
authors.lastname: Salvador
authors.forename: E
authors.initials: E
authors.lastname: Medina
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000930:Antidiarrheals / Q000627:therapeutic use; D001706:Biopsy; D002939:Ciprofloxacin / Q000627:therapeutic use; D003092:Colitis / Q000188:drug therapy / Q000473:pathology; D003106:Colon / Q000473:pathology; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D008139:Loperamide / Q000627:therapeutic use; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use; D010627:Phenethylamines / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use; D012460:Sulfasalazine / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000930:Antidiarrheals; D005765:Gastrointestinal Agents; D010276:Parasympatholytics; D010627:Phenethylamines; D000644:Quaternary Ammonium Compounds; C013934:octylonium; D012460:Sulfasalazine; D019804:Mesalamine; D002939:Ciprofloxacin; D004917:Erythromycin; D008139:Loperamide; C005096:mebeverine; D011241:Prednisone
vernacular_title: Colitis colágena: presentación de 12 casos.