[The effect of sodium nitroprusside on the membrane potential and mechanical tension of the smooth-muscle cells in the rat aorta].
The rat aorta smooth muscles were contracted and depolarised with high potassium or phenylephrin solution which was followed by a relaxation and repolarisation after sodium nitroprusside administration. The latter effect was decreased az a combined action of phenylephrin and high potassium solution. Nitroprusside seems to act through a cGMP-dependent potassium transient activation of the smooth muscle cell membrane.
Kovalev
I V
IV
Siberian Medical University, Tomsk, Russia.
Baskakov
M B
MB
Panov
A A
AA
Petrov
E Iu
EIu
Kapilevich
L V
LV
Medvedev
M A
MA
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D004566:Electrodes; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D009599:Nitroprusside / Q000494:pharmacology*; D015221:Potassium Channels / Q000819:agonists*; D051381:Rats; D013314:Stress, Mechanical
D015221:Potassium Channels; D009599:Nitroprusside; D006152:Cyclic GMP
Vliianie nitroprussida natriia na membrannyĭ potentsial i mekhanicheskoe napriazhenie gladkomyshechnykh kletok aorty krysy.