title: Leukemia cutis with prominent giant cell reaction.
abstract: We present a case of leukemia cutis associated with a prominent giant cell component. This lesion was initially diagnosed as chronic granulomatous inflammation 1 year before the definitive diagnosis of leukemia cutis was made. Skin biopsy specimens showed numerous Langhans-type giant cells occurring singly and as poorly formed granulomas. However, the majority of the infiltrate consisted of immature myeloid cells, positive for chloroacetate esterase, lysozyme, and CD 68. Subsequent peripheral blood and bone marrow examinations confirmed the progression of the disease to acute myeloid leukemia.
authors.affiliation: Department of Pathology, Eastern Virginia Medical School, Norfolk 23507, USA.
authors.forename: F K
authors.initials: FK
authors.lastname: Baksh
authors.forename: D
authors.initials: D
authors.lastname: Nathan
authors.forename: W
authors.initials: W
authors.lastname: Richardson
authors.forename: T
authors.initials: T
authors.lastname: Kestenbaum
authors.forename: J
authors.initials: J
authors.lastname: Woodroof
mesh_terms: D000368:Aged; D001854:Bone Marrow Cells / Q000473:pathology; D017809:Fatal Outcome; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D017254:Leukemic Infiltration / Q000473:pathology*; D008297:Male; D012867:Skin / Q000473:pathology*