title: Endoscopic treatment of urinary incontinence in children with primary epispadias.
abstract: OBJECTIVE
  To evaluate the efficacy of the endoscopic insertion of polydimethylsiloxane particles (Macroplastique, Uroplasty Inc) (MPQ) into the posterior urethral region of boys with urinary incontinence and primary epispadias.
  
  
  METHODS
  Between 1991 and 1995, 12 boys aged 3-7 years (mean 4.8) received an endoscopic submucosal injection with MPQ into the posterior urethra to correct urinary incontinence; the 12 boys were wet day and night. All patients had undergone a modified Cantwell epispadias repair before injection. The procedure was performed 24 times with a total volume of 83 mL of material injected into 59 sites in the posterior urethra (mean volume per injection 1.4 mL). The mean follow-up after injection was 10.8 months (range 3-22).
  
  
  RESULTS
  Three patients became completely dry, the degree of incontinence was improved in six and there was no change in three.
  
  
  CONCLUSIONS
  The preliminary results of this relatively non-invasive treatment are encouraging.
authors.affiliation: Great Ormond Street Hospital for Children NHS Trust, Institute of Urology, Middlesex Hospital, London, UK.
authors.forename: P G
authors.initials: PG
authors.lastname: Duffy
authors.forename: P G
authors.initials: PG
authors.lastname: Ransley
mesh_terms: D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004129:Dimethylpolysiloxanes / Q000008:administration & dosage*; D004724:Endoscopy; D004842:Epispadias / Q000150:complications* / Q000628:therapy; D006801:Humans; D007267:Injections; D008297:Male; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000209:etiology / Q000628:therapy*
chemical_list: D004129:Dimethylpolysiloxanes