A study on ester thiosemicarbazones.
The cyclization of ester thiosemicarbazones to two different heterocycles was studied for some new thiosemicarbazones, and only the formation of 1,2,4-triazol-5-thiols was attributed to the regioselectivity of the ring closure reaction, due to a steric hindrance of bulky groups. Next, some of the new compounds were tested for their in vitro antimicrobial and antitumor activities.
Ikizler
A A
AA
Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
Kahveci
B
B
Johansson
C B
CB
Celik
C
C
Yüksek
H
H
D000904:Antibiotics, Antitubercular / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
C111463:3-(4-chlorobenzyl)-1,2,4-triazol-5-thiol; C111462:3-(4-methylbenzyl)-1,2,4-triazol-5-thiol; D000904:Antibiotics, Antitubercular; D000970:Antineoplastic Agents; D013882:Thiosemicarbazones; D014230:Triazoles; C111460:ethyl 4-chlorophenylacetate thiosemicarbazone; C111458:ethyl 4-methylphenylacetate thiosemicarbazone