[Sexual differences in the development of a hyperthermic reaction in rats after the administration of Freund's complete adjuvant].
Application of Freund's complete adjuvant containing killed and dried Mycobacterium butyricum led to a two-phase hyperthermic response in white rats, much more obvious in female than in male rats. The difference seems to be due to a more obvious increase of the tumour necrosis alpha-factor, progesterone, and thyrotropic hormone in the blood of female rats, as well as to prevalence of pyretic activity over the pyretic one in them.
Semenenia
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Institute of Physiology, Beloruss. Acad. Sci., Minsk, Belorussia.
Gurin
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AV
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D005334:Fever / Q000097:blood / Q000139:chemically induced*; D005620:Freund's Adjuvant / Q000494:pharmacology*; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009161:Mycobacterium / Q000276:immunology; D011374:Progesterone / Q000097:blood; D051381:Rats; D012007:Rectum; D012727:Sex Characteristics; D013972:Thyrotropin / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D014409:Tumor Necrosis Factor-alpha; D011374:Progesterone; D013972:Thyrotropin; D005620:Freund's Adjuvant; D006854:Hydrocortisone
Polovye razlichiia v razvitii gipertermicheskoĭ reaktsii u krys posle vvedeniia polnogo ad''iuvanta Freĭnda.