Human and recombinant erythropoietin stimulate erythropoiesis in the goldfish Carassius auratus.
Erythropoietin (EPO) stimulates differentiation of erythrocytes and biosynthesis of haemoglobin in mammals. It has not been confirmed that EPO is effective in other vertebrates, so we attempted to verify the effectiveness of human-urinary and recombinant EPO on erythropoiesis of the goldfish Carassius auratus. The results indicate that both types of EPO produce an increase in haemoglobin, erythrocytes and erythroblasts number in peripheral blood of the goldfish; moreover, they stimulate erythropoiesis in lymphomyeloid tissue of kidney which, in normal conditions we find to be prevalently myelopoietic.
Taglialatela
R
R
Della Corte
F
F
D000704:Analysis of Variance; D000818:Animals; D004900:Erythroblasts / Q000187:drug effects; D004906:Erythrocyte Count / Q000187:drug effects; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology*; D006054:Goldfish / Q000097:blood*; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D011994:Recombinant Proteins
D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin