title: Dopamine markers and general cognitive ability.
abstract: Because general cognitive ability (g) is among the most heritable behavioural traits, it is a reasonable target for a search for quantitative trait loci (QTLs). We used a selected-extremes design to test candidate genes for allelic association with g. Polymorphisms in four genes in the dopamine system (DRD2, DRD3, DRD4, DAT1) were genotyped for 51 high g children with IQ scores > 130 and for 51 average g control children. No significant allelic or genotypic differences were found between the high g and average g groups for these markers of the dopamine system, even though the selected-extremes design provides power to detect QTL associations that involve a relative risk of about 1.5.
authors.affiliation: Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Denmark Hill, London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Ball
authors.forename: L
authors.initials: L
authors.lastname: Hill
authors.forename: T C
authors.initials: TC
authors.lastname: Eley
authors.forename: M J
authors.initials: MJ
authors.lastname: Chorney
authors.forename: K
authors.initials: K
authors.lastname: Chorney
authors.forename: L A
authors.initials: LA
authors.lastname: Thompson
authors.forename: D K
authors.initials: DK
authors.lastname: Detterman
authors.forename: C
authors.initials: C
authors.lastname: Benbow
authors.forename: D
authors.initials: D
authors.lastname: Lubinski
authors.forename: M
authors.initials: M
authors.lastname: Owen
authors.forename: P
authors.initials: P
authors.lastname: McGuffin
authors.forename: R
authors.initials: R
authors.lastname: Plomin
mesh_terms: D000293:Adolescent; D000483:Alleles; D015415:Biomarkers; D002648:Child; D003071:Cognition / Q000502:physiology*; D004247:DNA / Q000032:analysis; D004298:Dopamine / Q000235:genetics* / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D011110:Polymorphism, Genetic; D019655:Quantitative Trait, Heritable
chemical_list: D015415:Biomarkers; D004247:DNA; D004298:Dopamine