title: Trends in the incidence of upper extremity soft tissue malignancies: a 40-year review of the Connecticut State Tumor Registry.
abstract: BACKGROUND
  Although soft tissue malignancies of the upper extremity are rare, the management of these lesions has been controversial and the etiologic factors associated with the occurrence of these tumors are not well understood. The purpose of this study was to identify possible epidemiologic factors related to a recently noted rise in the occurrence of these tumors in the state of Connecticut.
  
  
  METHODS
  The occurrence of upper extremity soft tissue tumors over the past 40 years was reviewed in the Connecticut State Tumor Registry. Demographic data collected included occupational history, residence, and presence of concomitant malignancies. Tumor histology, the extent of resection, and the incidence of recurrences were also noted. Factors associated with recurrence were identified using linear regression analysis.
  
  
  RESULTS
  During the 40-year study period, 359 patients having upper extremity soft tissue tumors were entered into the Connecticut State Tumor Registry. An increasing trend in the number of upper extremity soft tissue tumors was evident. Many patients were involved in heavy industry or related fields. Fibrosarcoma and liposarcoma were the most common tumor types, occurring in 111 (30.3%) and 48 patients (13.2%), respectively. Sixty-seven patients presented with a synchronous second primary malignancy of the breast (49 patients), lung (seven patients), or gastrointestinal tract (five patients). Most patients (69.9%) underwent local excision of the soft tissue tumors, with fewer undergoing wide excision (20.3%) or radical excision (9.7%). Recurrence, which occurred in 144 patients, was found to be associated with extent of resection, occupational history, and concomitant malignancy. Delineation of such risk factors may be helpful in identifying patients in whom aggressive management may decrease recurrence and improve survival.
authors.affiliation: Saint Mary's Hospital/Yale University School of Medicine, Waterbury, CT, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Zahir
authors.forename: J A
authors.initials: JA
authors.lastname: Quin
authors.forename: W
authors.initials: W
authors.lastname: Brown
authors.forename: J G
authors.initials: JG
authors.lastname: Thomson
authors.forename: S J
authors.initials: SJ
authors.lastname: Dudrick
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001132:Arm; D002648:Child; D002675:Child, Preschool; D003237:Connecticut / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005354:Fibrosarcoma / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D006801:Humans; D015994:Incidence; D007223:Infant; D008080:Liposarcoma / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012042:Registries / Q000706:statistics & numerical data; D012307:Risk Factors; D012983:Soft Tissue Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery