Genes that regulate interleukin-4 expression in T cells.
Interleukin-4 is an immunomodulatory cytokine which plays a central role in the regulation of allergic and atopic immune responses. Significant progress has been made in gaining a detailed understanding of the transcriptional regulation of the interleukin-4 gene. The recent identification and characterization of several key transcription factors has helped to elucidate the molecular mechanisms of T helper cell cytokine gene expression.
Szabo
S J
SJ
Harvard School of Public Health, Department of Cancer Biology, Boston, MA 02115, USA. sjszabo@mbcrr.harvard.edu
Glimcher
L H
LH
Ho
I C
IC
D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics* / Q000276:immunology; D050800:STAT6 Transcription Factor; D013601:T-Lymphocytes / Q000276:immunology*; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D015847:Interleukin-4