Pleural disease during treatment with bromocriptine in patients previously exposed to asbestos.
Bromocriptine, which is used in the treatment of Parkinson's disease, can cause adverse pleuropulmonary reactions. Exposure to asbestos can result in similar lesions. Fifteen patients with former exposure to asbestos, who developed pleural fibrosis after treatment with bromocriptine, were observed independently in Sweden (11 patients) and Australia (four patients). The patients complained of malaise, often associated with weight loss, dyspnoea, and a disturbing cough. Laboratory values included increased erythrocyte sedimentation rate and a low haemoglobin level. Lung function tests showed a restrictive lung function defect. Chest radiographs showed bilateral pleural fibrosis, with small amounts of fluid in some cases. Soon after bromocriptine was withdrawn, the patients improved clinically, and the laboratory values returned to normal. However, in most cases, pleural fibrosis and a restrictive lung function defect persisted to some extent. In conclusion, in patients who develop pleuropulmonary fibrosis whilst being treated with bromocriptine, former exposure to asbestos should be investigated. Conversely, when pleural changes develop in a patient on bromocriptine and with prior exposure to asbestos, the possible causative role of the drug should be discussed. Special follow-up may be indicated when bromocriptine is planned in a patient with previous asbestos exposure, and if symptoms or signs of pleural fibrosis develop, bromocriptine withdrawal should be considered.
Hillerdal
G
G
Dept of Lung Medicine, Karolinska Hospital, Stockholm, Sweden.
Lee
J
J
Blomkvist
A
A
Rask-Andersen
A
A
Uddenfeldt
M
M
Koyi
H
H
Rasmussen
E
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001194:Asbestos / Q000009:adverse effects*; D001971:Bromocriptine / Q000009:adverse effects* / Q000627:therapeutic use; D018893:Bronchoalveolar Lavage; D015331:Cohort Studies; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy; D010995:Pleural Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D011859:Radiography; D012129:Respiratory Function Tests; D012307:Risk Factors
D000978:Antiparkinson Agents; D001194:Asbestos; D001971:Bromocriptine