title: [Auditory evoked magnetic fields in patients of pure word deafness].
abstract: Auditory evoked magnetic fields (AEF) were recorded in 2 cases with pure word deafness. AEF examination were performed with a novel 129-channel vector neuromagnetic imaging system (SBI 100). The latency and the location of equivalent current dipole (ECD) of N100 m after 1,000 Hz tone burst stimulation, one of the most prominent peak of AEF, were evaluated. One patient, 59-year-old man, suffered from left putaminal hemorrhage and the other, 59-year-old man, had a history of bilateral putaminal hemorrhage. There was no N100 m detected in the left temporal lobe with the right ear stimulation in both patients. However normal N100 m was obtained in the right hemisphere with the left ear stimulation in both cases. And the position of ECD of N100 m in the right hemisphere were correctly superimposed on the Heschl gyrus in brain MRI. The pathophysiology of pure word deafness has been postulated that a disconnection between Wernicke area and bilateral auditory inputs played one of important roles in progression of pure word deafness. Because there was no pathological lesion in temporal lobe verified by MRI study in both patients, N100 m in the left could not be evoked due to interception of the auditory pathway to the Heschl gyrus, but not due to destruction of Heschl gyrus. AEF test is one of the most useful tools in order to estimate central auditory function in patients with pure word deafness.
authors.affiliation: Department of Neurology, Kyoto Prefectural University of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Makino
authors.forename: Y
authors.initials: Y
authors.lastname: Takanashi
authors.forename: K
authors.initials: K
authors.lastname: Iwamoto
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: H
authors.initials: H
authors.lastname: Ohshima
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: R
authors.initials: R
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Endo
mesh_terms: D001041:Aphasia, Wernicke / Q000175:diagnosis / Q000503:physiopathology*; D001301:Audiometry, Pure-Tone; D001921:Brain / Q000473:pathology; D004292:Dominance, Cerebral / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged