title: Pancreatic adenocarcinoma: combination of MR imaging, MR angiography and MR cholangiopancreatography for the diagnosis and assessment of resectability.
abstract: The purpose of this study was to determine the possibility of integrating MR cholangiopancreatography (MRCP) and MR angiography (MRA) to conventional MR images in the diagnosis and assessment of resectability of pancreatic adenocarcinoma. Twenty-three patients with pancreatic adenocarcinoma were prospectively examined with MR. Conventional MR images were acquired in all patients. Three-dimensional MRCP and MRA images were acquired in all patients with suspected biliary and vascular involvement. Acquisition time was less than 45 min in all cases. Images were independently evaluated by two radiologists, with final reading decided by consensus among readers. Diagnosis was confirmed with surgery in 16 patients and with percutaneous biopsy in 7. Concordance among readers was high with a kappa value of 0.83. Pancreatic adenocarcinoma was observed in all patients. Correct assessment of unresectability due to vascular involvement was found in 22 of 23 patients. Biliary obstruction was evident in 13 patients, involving the biliary and pancreatic ducts in 9 and the biliary ducts only in 4. Technical advances permit extensive use of MRI in the evaluation of abdominal pathologies. The combination of MR imaging, MRCP, and MRA can provide sufficient information for the diagnosis and assessment of resectability of pancreatic adenocarcinoma, which otherwise would require three different exams.
authors.affiliation: Department of Radiology, II Chair, University of Rome "La Sapienza", V.le Regina Elena, 324, I-00 161 Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Catalano
authors.forename: P
authors.initials: P
authors.lastname: Pavone
authors.forename: A
authors.initials: A
authors.lastname: Laghi
authors.forename: V
authors.initials: V
authors.lastname: Panebianco
authors.forename: A
authors.initials: A
authors.lastname: Scipioni
authors.forename: F
authors.initials: F
authors.lastname: Fanelli
authors.forename: R
authors.initials: R
authors.lastname: Brillo
authors.forename: R
authors.initials: R
authors.lastname: Passariello
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D001158:Arteries / Q000473:pathology; D001652:Bile Ducts / Q000473:pathology; D001706:Biopsy; D002779:Cholestasis / Q000175:diagnosis / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010179:Pancreas / Q000098:blood supply / Q000473:pathology; D010183:Pancreatic Ducts / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010347:Patient Care Planning; D011446:Prospective Studies; D013154:Spleen / Q000473:pathology