[The effect of short term administration of cordafen on lipid peroxidation, activity of certain antioxidant enzymes and levels of reduced glutathione in erythrocytes].
After 3 days of orally administrated cordafen (nifedipine) (30 mg per day divided in 3 equal doses) we revealed in red blood cells: statistically significant decrease of malonyl dialdehyde concentration, statistically significant increase of selenium-dependent glutathione peroxidase activity and superoxide dismutase activity. Also increased mean reduced glutathione concentration in erythrocytes of human peripheral blood was found, though statistically nonsignificant.
Misiewicz
A
A
VI Katedry i Kliniki Chorób Wewnetrznych Slaskiej Akademii Medycznej w Katowicach.
Radwan
K
K
Dziewit
T
T
Kowalczyk-Kowalska
M
M
Dutkiewicz
B
B
D000284:Administration, Oral; D000328:Adult; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*; D010088:Oxidoreductases / Q000187:drug effects / Q000378:metabolism; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism
D002121:Calcium Channel Blockers; D010088:Oxidoreductases; D013482:Superoxide Dismutase; D005978:Glutathione; D009543:Nifedipine
Wpływ krótkotrwałego podawania cordafenu na peroksydacje lipidów, aktywność niektórych enzymów antyutleniajacych i stezenie zredukowanego glutationu w krwinkach czerwonych.