title: Adult ganglioneuroblastoma of the anterior mediastinum.
abstract: A case of ganglioneuroblastoma occurring in the anterior mediastinum of a 79 year-old man is reported. The tumor was mainly composed of neuroblasts with occasional ganglion cells. Foci of melanin-laden cells were also identified. Immunohistochemistry revealed that the tumor cells showed both schwannian and melanocytic differentiation with immunoreactivity to anti-S100 protein and anti-HMB45 antibodies. In addition, the tumor contained several microcysts lined by squamous epithelial and one lymphoid tissue abundant in T lymphocytes, which appeared to be derived from thymic tissue. This case is unique in that neuroblastoma group tumors including ganglioneuroblastoma is uncommon in the elderly and in the thymic region, and rarely shows melanocytic differentiation. To the best of our knowledge, this case is a tumor of neuroblastoma group occurring in the eldest patient.
authors.affiliation: Department of Pathology, Yokohama City University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Y
authors.initials: Y
authors.lastname: Miyagi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Miyashita
authors.forename: S
authors.initials: S
authors.lastname: Shigematsu
authors.forename: I
authors.initials: I
authors.lastname: Aoki
authors.forename: Y
authors.initials: Y
authors.lastname: Nakatani
authors.forename: K
authors.initials: K
authors.lastname: Misugi
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D002454:Cell Differentiation; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D018305:Ganglioneuroblastoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008544:Melanocytes / Q000648:ultrastructure
chemical_list: D014408:Biomarkers, Tumor; D005047:Etoposide; D002945:Cisplatin