Pigmented ("black") extraadrenal paraganglioma.
A pigmented ("black") extraadrenal paraganglioma was discovered incidentally in a 57-year-old woman during ultrasonography. The tumor was located in the retroperitoneum near the superior border of the right kidney. Results of preoperative fine-needle aspiration and intraoperative frozen sectioning of the resected jet-black tumor (13 cm in diameter, 225 g) were both interpreted as suspicious for malignant melanoma. Histomorphology and immunohistochemistry were diagnostic for paraganglioma. Electron microscopy showed numerous dense-core neurosecretory-type granules, as well as abundant, larger pleomorphic electron-dense granules; most were consistent with lipofuscin or neuromelanin. No melanosomes or premelanosomes were identified. Histochemical stains showed that the pigment most likely is neuromelanin, a nonenzymatic or oxidative waste product of catecholamine metabolism. Eighteen other examples of pigmented paragangliomas have been reported in various sites in the English literature during the last 12 years; most indicate the presence of melanosomes or premelanosomes using electron microscopy, whereas in a minority of cases the pigment has not been characterized rigorously. Common embryogenesis from neural crest may help explain the overlapping phenotype of melanocytes and cells of paraganglioma.
Lack
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Department of Pathology, Georgetown University School of Medicine, Washington, DC 20007, USA.
Kim
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Reed
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D005260:Female; D006801:Humans; D008875:Middle Aged; D010236:Paraganglioma, Extra-Adrenal / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D010860:Pigments, Biological
D010860:Pigments, Biological