title: Myocardial perfusion characteristics and hemodynamic profile of MRX-115, a venous echocardiographic contrast agent, during acute myocardial infarction.
abstract: We sought to determine whether MRX-115, a new venous echocardiographic contrast agent, could accurately assess risk area during coronary occlusion and infarct size after reperfusion by using novel imaging modalities meant to selectively enhance contrast signals. In 12 open-chest dogs, venous injections of 0.5 ml of MRX-115 were performed during baseline and coronary occlusion and after reperfusion in the presence of exogenous hyperemia. Ultrasound was transmitted at 2 MHz and received at both 2 MHz (fundamental) and 4 MHz (harmonic) frequencies during continuous and intermittent (end-systolic only) imaging. The risk area during coronary occlusion was compared with technetium autoradiography, and the infarct size after reperfusion was compared with postmortem tissue staining. MRX-115 produced no alterations in hemodynamic or pulmonary gas exchange at any stage. During continuous (both fundamental and harmonic) and intermittent fundamental imaging, measurements of perfusion defects were precluded in many dogs by either poor signal enhancement or posterior wall attenuation. By comparison, these measurements were possible during intermittent harmonic imaging in all dogs except one, which had a very small infarction during reflow. Correlation analysis between perfusion defect size on intermittent harmonic imaging and either autoradiographic risk area or postmortem infarct size gave r values of 0.83 and 0.92, respectively. We conclude that MRX-115 is hemodynamically well tolerated and, when imaging is performed after venous injection, can accurately assess regions of hypoperfusion when combined with intermittent harmonic imaging. These results are promising for the use of this approach in patients with acute myocardial infarction.
authors.affiliation: Cardiovascular Division, University of Virginia Medical Center, Charlottesville 22908, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Lindner
authors.forename: C
authors.initials: C
authors.lastname: Firschke
authors.forename: K
authors.initials: K
authors.lastname: Wei
authors.forename: N C
authors.initials: NC
authors.lastname: Goodman
authors.forename: D M
authors.initials: DM
authors.lastname: Skyba
authors.forename: S
authors.initials: S
authors.lastname: Kaul
mesh_terms: D000818:Animals; D001345:Autoradiography; D003287:Contrast Media / Q000008:administration & dosage; D003326:Coronary Circulation; D004285:Dogs; D004452:Echocardiography; D005466:Fluorocarbons / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects; D007275:Injections, Intravenous; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D013668:Technetium Tc 99m Aggregated Albumin; C042852:perflutren