Hydroxylated polychlorinated biphenyls: distribution in the pregnant mouse.
1. In the pregnant C57BL mouse the disposition of a single, intravenous low dose of 14C-labelled 4-hydroxy-3,5,3',4'-tetrachlorobiphenyl (4-OH-TCB) or 4-hydroxy-3,5,2',3',4'-pentachloro-biphenyl (4-OH-PeCB1) was monitored by liquid scintillation counting and whole-body autoradiography. The compounds were placentally transferred and accumulated in the foetal tissues (e.g. plasma and liver). Also, maternal accumulation was observed in selected tissues, including liver, adrenal gland, adipose tissue and yolk sac placenta. 2. The foetal concentration of both hydroxy-PCBs increased with time up 24 h post-exposure and the foetal plasma concentration with at this time-point two-fold of that in maternal plasma. Chemical analysis of maternal plasma and liver showed no metabolism of the administered compounds. 3. In the pregnant C57BL mouse at late gestation, exposure to 4-OH-TCB generally resulted in a higher foetal and maternal tissue retention than did 4-OH-PeCB1. The estimated elimination half-lives (t 1/2) of 4-OH-TCB in maternal liver and plasma were 69 and 13 h respectively, and for 4-OH-PeCB1 were 17 and 13 h. 4. No differences in foetal tissue concentration of 4-OH-TCB were observed between the C57BL, and NMRI mouse. In contrast, earlier studies have shown that the PCB congener CB-77, the parent compound of 4-OH-TCB, resulted in a C57BL/NMRI foetal ratio of 1:5.
Sinjari
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T
Department of Pharmaceutical Biosciences, Uppsala University, Sweden.
Klasson-Wehler
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Hovander
L
L
Darnerud
P O
PO
D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes; D005260:Female; D005333:Fetus / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D051379:Mice; D008810:Mice, Inbred C57BL; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics*; D011247:Pregnancy; D012588:Scintillation Counting; D014018:Tissue Distribution
C111118:2',3,3',4',5-pentachloro-4-hydroxybiphenyl; C111117:3,3',4',5-tetrachloro-4-hydroxybiphenyl; D002250:Carbon Radioisotopes; D011078:Polychlorinated Biphenyls