[Effect of calcium channel blockers on developing nervous syndrome of high pressure and nitrogen narcosis in mice].
In the experiments conducted on mice which prior to compression in a heliox environment have been injected the blockers of various types of calcium channels (flunarezine, verapramil and nifedipine) as well as bemethyl (actoprotector) and oxymethacye (antioxidant) there escaped detection of noticeable effect of these drugs on developing the high pressure nervous syndrome (HPNS). On exposure to the hyperbaric nitrogen-oxygen environment verapromil (phenylalkulamine blocker of L-type calcium channels) had a protection effect with respect to a convulsive component of the nitrogen narcosis.
Sledkov
A I
AI
Institute of Evolution Physiology and Biochemistry of IM Sechenov RAN, Saint Petersburg.
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004195:Disease Models, Animal; D006610:High Pressure Neurological Syndrome / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D007222:Inert Gas Narcosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice
D002121:Calcium Channel Blockers
Vliianie blokatorov kal'tsievykh kanalov na razvitie azotnogo narkoza i nervnogo sindroma vysokikh davlenií u mysheí.