title: Cutaneous lymphadenoma: an adnexal neoplasm with intralobular activated lymphoid cells.
abstract: Cutaneous lymphadenoma is an uncommon epithelial neoplasm with a controverted adnexal differentiation. We report a typical case of cutaneous lymphadenoma that developed on the left cheek of a 18-year-old woman. Histologically, the neoplasm consisted of lobules of basaloid cells with a peripheral palisading array and filled with a lymphocyte-predmoninant mixed cellular population. Numerous intralobular cells with ample amphopilic cytoplasm, large vesicular nuclei, and prominent nucleoli also were noticed. Immunohistochemical study showed labeling of these Reed-Sternberg-like large cells by antibodies against CD30 antigen. Our findings suggest that cutaneous lymphadenoma is a poorly differentiated adnexal neoplasm, probably trichoblastoma-related, where a singular interaction with several immune cells is established, including activated large lymphocytes analogous to those malignantly proliferating in Hodgkin's disease.
authors.affiliation: Seccion de Dermatologia, Hospital Nuestra Señora de Sonsóles, Avila, España.
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez-Díaz
authors.forename: C
authors.initials: C
authors.lastname: Román
authors.forename: M
authors.initials: M
authors.lastname: Yuste
authors.forename: A G
authors.initials: AG
authors.lastname: Morán
authors.forename: T
authors.initials: T
authors.lastname: Aramendi
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D002610:Cheek / Q000473:pathology; D005153:Facial Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D008223:Lymphoma / Q000737:chemistry / Q000473:pathology*; D009375:Neoplasms, Glandular and Epithelial / Q000737:chemistry / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D015415:Biomarkers; D017730:Ki-1 Antigen; D009418:S100 Proteins; D017493:Leukocyte Common Antigens