title: Transitional cell carcinoma of the vagina with pagetoid spread pattern.
abstract: A distinctive variant of a papillary noninvasive transitional cell carcinoma (TCC) of the vagina removed from a postmenopausal woman is described. The neoplasm was evaluated by immunohistochemistry. The designation of this neoplasm as a TCC is supported by its morphological features and its coexpression for cytokeratin (CK) 7 and CK 20. Its main feature is pagetoid infiltration into adjacent vaginal epithelium. This is the second reported case involving a transitional cell metaplasia (TCM) of the vagina, a possible precursor lesion of the TCC.
authors.affiliation: Division of Surgical Pathology, Cantonal Hospital, Baden, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Singer
authors.forename: M K
authors.initials: MK
authors.lastname: Hohl
authors.forename: F
authors.initials: F
authors.lastname: Hering
authors.forename: M
authors.initials: M
authors.lastname: Anabitarte
mesh_terms: D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008679:Metaplasia; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D017698:Postmenopause; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery; D014621:Vagina / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D007633:Keratins