title: Delusional disorder in a boy with phenylketonuria and amine metabolites in the cerebrospinal fluid after treatment with neuroleptics.
abstract: A case report of a 16-year-old boy with the classical form of phenylketonuria (PKU) and suffering from a delusional disorder is presented. He did not respond to a traditional antipsychotic medication but improved on an atypical antipsychotic, risperidone. The cerebrospinal fluid metabolites of the biogenic amines were measured and are also reported in the context of a recent interest in the ratios of these amine metabolites in schizophrenia. It is proposed that such dually diagnosed patients with PKU may provide a model in which to test the prevalent biogenic amine theories in psychiatric disorders.
authors.affiliation: Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75235-9070, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Shiwach
authors.forename: S
authors.initials: S
authors.lastname: Sheikha
mesh_terms: D000293:Adolescent; D000588:Amines / Q000134:cerebrospinal fluid* / Q000378:metabolism; D006801:Humans; D008297:Male; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000150:complications*; D012563:Schizophrenia, Paranoid / Q000134:cerebrospinal fluid / Q000150:complications*
chemical_list: D000588:Amines; D010649:Phenylalanine