[The clinical and experimental evaluation of the pharmacological efficacy of the new antidiarrheal preparation ftorazol].
A clinical trial of the new antidiarrheal drug of antisecretory action fluorasol was studied with patients with salmonellosis and food toxic infections. 65 patients had moderate and 53 severe symptoms. It was established that fluorasol was superior to basic rehydration therapy in relieving diarrheal syndrome irrespective of severity of acute intestinal infections. Clinical effects on intoxication were not registered. Antidiarrheal activity of fluorasol was confirmed on the model of experimental diarrhea on isolated loops of the rat small intestine. Liquid secretion into the lumen of small intestinal isolated loops in the presence of fluorasol substance fell twofold compared to control loops.
Namitokov
Kh A
KhA
Pak
S G
SG
Astashkin
E I
EI
Grachev
S V
SV
Malova
V A
VA
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology* / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D005517:Foodborne Diseases / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats; D017208:Rats, Wistar
D000930:Antidiarrheals; D001562:Benzimidazoles; C111636:fluorasol
Otsenka farmakologicheskoĭ éffektivnosti novogo antidiareĭnogo preparata ftorazol v klinike i éksperimente.