title: Assessment of cure by detection of circulating antigens in serum and urine, following schistosomiasis mass treatment in two villages of the Office du Niger, Mali.
abstract: Eight weeks after mass chemotherapy with 40 mg/kg praziquantel in two villages in Office du Niger (an irrigation area in Mali, endemic for both Schistosoma haematobium and Schistosoma mansoni) the circulating anodic (CAA) and cathodic (CCA) antigen detection assays were carried out on serum and urine samples. Both prior and post treatment highest prevalence was measured with the urine-CCA assay. Cure rates determined by antigen detection were almost half that of the egg counting methods. It was shown that the reduction in intensity should be preferentially assessed by the serum-CAA assay. Compared with egg detection, a single antigen detection assay gave a much better assessment of the impact of chemotherapy.
authors.affiliation: Universiteit Gent (RUG), Faculteit Diergeneeskunde, Laboratorium voor Parasitologie, Merelbeke, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: De Clercq
authors.forename: M
authors.initials: M
authors.lastname: Sacko
authors.forename: J
authors.initials: J
authors.lastname: Vercruysse
authors.forename: V
authors.initials: V
authors.lastname: vanden Bussche
authors.forename: A
authors.initials: A
authors.lastname: Landouré
authors.forename: A
authors.initials: A
authors.lastname: Diarra
authors.forename: B
authors.initials: B
authors.lastname: Gryseels
authors.forename: A
authors.initials: A
authors.lastname: Deelder
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000097:blood* / Q000652:urine*; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use; D008302:Mali; D011223:Praziquantel / Q000627:therapeutic use; D012548:Schistosoma haematobium / Q000302:isolation & purification*; D012550:Schistosoma mansoni / Q000302:isolation & purification*; D012552:Schistosomiasis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000652:urine; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D000947:Antigens, Helminth; D000980:Antiplatyhelmintic Agents; D011223:Praziquantel