[The effectiveness of ramipril in the treatment of diabetic nephropathy in normotensive children and adolescents].
To study the effectiveness of ACE-inhibitors in diabetic nephropathy (DN) 12 male and 16 female patients aged 13-21 years with DN having normal blood pressure (BP) were given ramipril (tritace) in a dose 2.5-5 mg/day in the course of 12-24 weeks. Efficacy and safety of the treatment were assessed by changes in albuminuria and proteinuria, BP. Reduction of albuminuria occurred in 19(79.1%) out of 24 patients with microalbuminuria, in 13(54.1%) of them urine excretion of albumin returned to normal levels. All the patients with proteinuria and macroalbuminuria benefited from ramipril therapy because their proteinuria diminished or even disappeared (2 cases). The persistence of the antiproteinuria effect on posttreatment week 12 was 66.6%. Ramipril effect on BP was minimal. It is inferred that ramipril is effective in the treatment of DN at the stage of microalbuminuria and proteinuria in patients with normal BP.
Sivous
G I
GI
Kafedra éndokrinologii detskogo i podrostkovogo vozrasta Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Tsentral'naia klinicheskaia bol'nitsa MPS, Moskva.
Kasatkina
E P
EP
Samsonova
L N
LN
Voĭchik
E A
EA
Gerasimov
N P
NP
D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure; D002648:Child; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D017257:Ramipril / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D017257:Ramipril
Effektivnost' ramiprila v lechenii diabeticheskoĭ nefropatii u deteĭ i podrostkov s normal'nym urovnem arterial'nogo davleniia.