Effect of soluble complement receptor type 1 on porphyrin-induced phototoxicity in guinea pigs.
The effect of recombinant human soluble complement receptor type 1 (sCR1) on the porphyrin-mediated phototoxic reaction was evaluated in guinea pigs. Phototoxicity was induced in the animals by intraperitoneal injection of hematoporphyrin derivative (HpD), followed by irradiation at a wavelength range of 320-450 nm. sCR1 administration decreased CH50 titers in a dose-dependent fashion, while it only moderately suppressed HpD/radiation-induced ear swelling at a high dose. These findings suggest that phototoxic dermatological changes in cutaneous porphyrias are not solely due to complement activation.
Nomura
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Dermatology Service, New York Veterans Affair Medical Center, USA.
Lim
H W
HW
Levin
J L
JL
Sassa
S
S
D000818:Animals; D015941:Complement Hemolytic Activity Assay; D003169:Complement Inactivator Proteins / Q000494:pharmacology; D017484:Dermatitis, Phototoxic / Q000276:immunology*; D004195:Disease Models, Animal; D004347:Drug Interactions; D004423:Ear / Q000473:pathology; D006168:Guinea Pigs; D006801:Humans; D011166:Porphyrins / Q000494:pharmacology*; D011951:Receptors, Complement / Q000097:blood; D011994:Recombinant Proteins / Q000097:blood / Q000494:pharmacology; D012995:Solubility
D003169:Complement Inactivator Proteins; D011166:Porphyrins; D011951:Receptors, Complement; D011994:Recombinant Proteins