Candida funisitis: A clinicopathologic study of 32 cases.
We report on 32 cases of Candida funisitis and describe the associated clinicopathologic features. The Candida funisitis was characterized grossly by small, circumscribed, yellow-white nodules on the umbilical cord surface and, microscopically, by subamnionic microabscesses in which fungal organisms were demonstrable. Chorioamnionitis was present in all cases. Twenty-four (75%) of the 32 infants were premature. There were 7 perinatal deaths, all in immature fetuses. Five (16%) of the 32 fetuses had congenital candidiasis. Five (16%) of the mothers had a history of intrauterine foreign body, including intrauterine contraceptive device in three and cervical cerclage in two. The diagnosis of Candida funisitis should prompt a careful examination for fetal infection, even though it is associated with congenital candidiasis in only a minority of the cases.
Qureshi
F
F
Department of Pathology, Hutzel Hospital, 4707 St. Antoine Boulevard, Detroit, MI 48201, USA.
Jacques
S M
SM
Bendon
R W
RW
Faye-Peterson
O M
OM
Heifetz
S A
SA
Redline
R
R
Sander
C M
CM
D000328:Adult; D002177:Candidiasis / Q000473:pathology*; D005260:Female; D005315:Fetal Diseases / Q000382:microbiology / Q000473:pathology*; D005865:Gestational Age; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000382:microbiology / Q000473:pathology; D010920:Placenta / Q000382:microbiology / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000473:pathology*; D014470:Umbilical Cord / Q000382:microbiology / Q000473:pathology*