[The reactive and/or repair role of the smooth muscle cells in Horton's arteritis].
A recent view of atherosclerosis indicates vascular smooth muscle cell proliferation not only as a response-to-injury but also as an essential reparative process leading to plaque stabilization. To assess the role of vascular smooth muscle cell in vasculitides we studied, as a model, 10 cases of Horton's arteritis. In particular, we investigated by immunohistochemical analysis cellular population and proliferation rate in the intimal layer. As in atherosclerotic plaques, intimal thickening in arteritis is essentially due to proliferation and migration of vascular smooth muscle cells. We suppose that, whatever the vascular disease, intimal hyperplasia contributes to stability of the vessel's wall; however the reactive/reparative process is extremely slow in spontaneous atherosclerosis, accelerated in arteritis.
Gori
F
F
Istituto di Anatomia e Istologia Patologica, Università di Firenze.
Baroni
G
G
Caldarella
A
A
Pedemonte
E
E
Dini
M
M
D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division; D002465:Cell Movement; D005260:Female; D013700:Giant Cell Arteritis / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D013699:Temporal Arteries / Q000473:pathology*
Il ruolo reattivo e/o riparativo delle cellule muscolari lisce nell'arterite di Horton.