Traumatic brain injury-associated delayed sleep phase syndrome.
A 15-year-old girl developed a prominent delayed sleep phase syndrome (DSPS) following traumatic brain injury. Several physiological markers of the sleep-wake rhythm: plasma melatonin, body temperature, wrist activity and sleep architecture (EEG) were delayed almost half a day, returning to normal after treatment with 5 mg melatonin. This report suggests an association between traumatic brain injury and DSPS. Awareness of this phenomenon may result in better possibilities for treatment of patients with brain injury.
Nagtegaal
J E
JE
Department of Clinical Pharmacy, Hospital de Gelderse Vallei, Bennekom, The Netherlands.
Kerkhof
G A
GA
Smits
M G
MG
Swart
A C
AC
van der Meer
Y G
YG
D000293:Adolescent; D001831:Body Temperature / Q000502:physiology; D001930:Brain Injuries / Q000150:complications*; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D008550:Melatonin / Q000097:blood / Q000627:therapeutic use; D008991:Monitoring, Physiologic; D012007:Rectum / Q000503:physiopathology; D012894:Sleep Stages / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D013577:Syndrome; D013997:Time Factors
D008550:Melatonin