Integrin chatter and vascular function in diabetic retinopathy.
The interplay between adhesion receptors and proteolytic cascades is crucial for cell proliferation and migration in the (patho-)physiology of vascular function. Disregulated angiogenesis in diabetic retinopathy appears to be associated with the appearance of advanced glycation end products that disturb interactions between capillary cells and extracellular matrix. Vitronectin receptor-type integrins are expressed on angiogenic endothelial cells and contribute to unwanted vascular sprouting in the retinal tissue. In a hypoxia-induced retinal neovascularization model, intervention with low molecular weight integrin antagonist resulted in significant reduction of unwanted angiogenesis indicating that this angiostatic therapy appears to be promising also for late complications in diabetes.
Preissner
K T
KT
Haemostasis Research Unit, Kerckhoff Klinik, MPI, Bad Nauheim, Germany.
Kanse
S M
SM
Hammes
H P
HP
D003930:Diabetic Retinopathy / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000037:antagonists & inhibitors / Q000502:physiology*; D010960:Plasminogen Activators / Q000378:metabolism; D019030:Receptors, Vitronectin / Q000378:metabolism; D012160:Retina / Q000378:metabolism; D015861:Retinal Neovascularization / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism
D017127:Glycation End Products, Advanced; D016023:Integrins; D019030:Receptors, Vitronectin; D010960:Plasminogen Activators