[The role of glucocorticoids in a modification of the hypothalamo-hypophyseal-adrenal cortical function of rats induced by stress exposures in early ontogeny].
In the rat litter, saline injections during stress-hyporesponsive period induced long-lasting changes in the function of the hypothalamo-pituitary-adrenocortical system. As adults, the rats revealed increased basal and decreased emotional stress-induced levels of the plasma corticosterone and a disorder in the adrenocortical diurnal rhythm. Hydrocortisone injections prevented the long-lasting effects of the stress. The glycocorticoid deficiency during stress seems to mediate the long-lasting effects.
Maslova
L N
LN
Institute of Cytology and Genetics, Siberian Branch, Russian Acad. Sci., Novosibirsk, Russia.
Naumenko
E V
EV
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D003345:Corticosterone / Q000097:blood; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood / Q000209:etiology / Q000503:physiopathology*
D005938:Glucocorticoids; D003345:Corticosterone; D006854:Hydrocortisone
O roli gliukokortikoidov v modifikatsii gipotalamo-gipofizarno-adrenokortikal'noĭ funktsii u krys, vyzvannoĭ stressornymi vozdeĭstviiami v rannem ontogeneze.