New steroidal constituents of the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells.
Phytochemical examination of the underground parts of Ruscus aculeatus has led to the isolation of a total of twelve steroidal saponins, including seven new ones. The structures of the new saponins were determined by spectroscopic analysis and chemical evidence. The furostanol saponin, having a diglycoside moiety modified with a (2S,3S)-2-hydroxy-3-methylpentanoic acid group and an acetic acid group, and its corresponding spirostanol saponin exhibited cytostatic activity on leukemia HL-60 cells.
Mimaki
Y
Y
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Kuroda
M
M
Kameyama
A
A
Yokosuka
A
A
Sashida
Y
Y
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002247:Carbon Isotopes; D018922:HL-60 Cells / Q000187:drug effects*; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D002247:Carbon Isotopes; D010936:Plant Extracts; D013256:Steroids