Clinical-pathological study of uterine leiomyomas with high mitotic activity.
OBJECTIVE
To evaluate clinical-pathological aspects of mitotically active leiomyomas.


METHODS
Twenty patients with smooth muscle tumors of the uterus, with 5-9 mitotic figures per 10 high power fields and without atypia or necrosis were studied. The clinical and pathological characteristics of these tumors were reviewed and analyzed.


RESULTS
Patients' ages ranged from 33 to 63 years (mean 42.5 years). The size of the tumors ranged from 1.5 to 9.5 cm (mean 5.4 cm). On gross examination all tumors appeared as typical leiomyomas. Treatment included hysterectomy in 16 patients and myomectomy in four. Follow-up periods ranged from 1.5 to 11 years (mean 6.8 years). None of the patients developed a recurrent tumor.


CONCLUSIONS
The benign clinical behavior of such tumors supports their current designation as mitotically active leiomyomas, thus deleting the previous misnomer 'smooth muscle tumors of uncertain malignant potential'. Myomectomy is an appropriate treatment, particularly in young patients interested in reproduction.
Dgani
R
R
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Piura
B
B
Ben-Baruch
G
G
Open
M
M
Glezerman
M
M
Nass
D
D
Czernobilsky
B
B
Yanai-Inbar
I
I
Elchalal
U
U
D000328:Adult; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D008940:Mitotic Index; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery