title: Survival of patients who needed salvage surgery for recurrence after radiotherapy for oral carcinoma.
abstract: OBJECTIVE
  To find out how long patients with oral carcinoma survived after the primary tumour had been treated by radiotherapy and who required salvage surgery for recurrence; to see if there were any significant differences in age, sex, site, size, and histology of the tumours in relation to survival; and to see if the time of the recurrence had any effect on the survival.
  
  
  METHODS
  Retrospective analysis of case notes.
  
  
  METHODS
  Teaching Hospital Scotland.
  
  
  METHODS
  370 consecutive patients, 187 (51%) of whom were initially treated by radiotherapy; 58 of the 187 (31%) developed a recurrence that was considered suitable for salvage surgery.
  
  
  CONCLUSIONS
  43/58 patients had died and 15 patients were still alive at the time of the study, the median (range) survival of the group was 21 (6-89) months compared with 72 (19-212) months, respectively (P = 0.0001). Other significant difference included age at presentation for men (P = 0.004), and the increased likelihood of survival if the initial site of the tumour was the tongue (P = 0.02). There was also a highly significant correlation between time to recurrence and survival amongst those who died (P = 0.002). A short recurrence time may suggest a less radical surgical salvage option if reduced survival is likely. Why there should be such an association is unknown.
authors.affiliation: Department of Maxillofacial Surgery and Oral Surgery, Royal Gwent Hospital, Glan Hafren NHS Trust, Newport, UK.
authors.forename: J
authors.initials: J
authors.lastname: Llewelyn
authors.forename: R
authors.initials: R
authors.lastname: Mitchell
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000601:surgery*; D016879:Salvage Therapy; D012737:Sex Factors; D018709:Statistics, Nonparametric; D015996:Survival Rate; D013997:Time Factors