Differential effects of alcohol on the cortical processing of foreign and native language.
The effect of alcohol (ethanol) on cortical processing of Finnish vs. English words in Finnish-speaking subjects was studied by recording auditory event-related potentials in 10 subjects who had started studying English at the age of 9-10 years. At the beginning of the block of 100 words, the subject heard an introductory sentence. Half of the words completed the sentence well and the other half did not. The subject pressed a reaction key immediately after hearing a proper word. After the control condition, the subject ingested alcohol (1 ml/kg). Alcohol attenuated the amplitude of N100 to both Finnish and English words, this attenuation being significantly stronger for English than for Finnish words. The early differential effect of alcohol suggests that language-specific information is extracted in the cortex already approximately 100 ms from the word onset. The results are in line with animal experiments demonstrating that alcohol selectively affects the activity of single units involved in newer forms of behavior.
Alexandrov
Y
Y
Laboratory of Neural Basis of Mind, Russian Academy of Sciences, Moscow, Russia.
Sams
M
M
Lavikainen
J
J
Reinikainen
K
K
Näätänen
R
R
D000161:Acoustic Stimulation; D000328:Adult; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008606:Mental Processes / Q000502:physiology*
D002492:Central Nervous System Depressants; D000431:Ethanol