[The dependence of shifts in arterial pressure and cardiac output during alpha-adrenoreceptor stimulation on the initial (controlled) tonus of arterial vessels in rats].
A significant decrease in arterial pressure and total peripheral resistance occurred following elevation of the initial blood pressure to 160 mm Hg with mesathone in anesthetised rats. The increase in the cardiac output remaining unchanged. Vascular and cardiac mechanisms of the revealed relationships are discussed.
Osadchiĭ
L I
LI
Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, Russia.
Balueva
T V
TV
Sergeev
I V
IV
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002302:Cardiac Output / Q000187:drug effects* / Q000502:physiology; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D011942:Receptors, Adrenergic, alpha; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D010656:Phenylephrine
Zavisimost' sdvigov arterial'nogo davleniia i serdechnogo vybrosa pri stimuliatsii al'fa-adrenoretseptorov ot iskhodnogo (upravliaemogo) tonusa arterial'nykh sosudov u krys.