[Parkinsonism induced by propiverine hydrochloride--report of 3 cases].
We report 3 cases of parkinsonism (ages ranging between 79 and 86) induced by propiverine hydrochloride (P-4), an anticholinergic drug with a direct effect on the smooth muscle of the bladder, used for the treatment of patients with urinary frequency and/or incontinence. An 87-year-old man with no neurological disorders developed parkinsonism for the first time soon after administration of P-4. In two other patients already diagnosed with parkinsonism, the disease condition worsened after administration of P-4. Their symptoms and signs were characterized by gait disturbance (marche à petits pas) and bradykinesia. All patients recovered from P-4-induced parkinsonism after interruption of P-4. We must watch carefully for the development or progression of parkinsonism when administering P-4 to elderly people.
Sugiyama
Y
Y
Department of Neurology, Kanazawa Municipal Hospital.
D000368:Aged; D000369:Aged, 80 and over; D001561:Benzilates / Q000009:adverse effects*; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D005684:Gait; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000009:adverse effects*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D011470:Prostatic Hyperplasia / Q000150:complications; D014555:Urination Disorders / Q000188:drug therapy / Q000209:etiology
D001561:Benzilates; D018680:Cholinergic Antagonists; D010276:Parasympatholytics; C015586:propiverine