title: Incidence of new-onset hypercholesterolemia in renal transplant patients treated with FK506 or cyclosporine.
abstract: In this study, we compare cholesterol levels during the first year after renal transplantation in FK506 (Prograf)- and cyclosporine-treated patients matched for cumulative first-year steroid dose and hypercholesterolemia risk factors. All patients had pretransplant cholesterol levels < 200 mg/dl. At 3 months posttransplant, 68% of the cyclosporine-treated patients had at least one cholesterol level greater than 200 mg/dl compared with 30% of the FK506-treated patients (P < 0.05). At the end of the year, 26% of FK506- and 67% of cyclosporine-treated patients remained hypercholesterolemic (P < 0.05). We conclude that cyclosporine has inherently more effect on cholesterol levels than FK506 during the first year after kidney transplantation.
authors.affiliation: National Institute of Transplantation, Los Angeles, California 90057, USA.
authors.forename: R
authors.initials: R
authors.lastname: Satterthwaite
authors.forename: S
authors.initials: S
authors.lastname: Aswad
authors.forename: V
authors.initials: V
authors.lastname: Sunga
authors.forename: H
authors.initials: H
authors.lastname: Shidban
authors.forename: T
authors.initials: T
authors.lastname: Bogaard
authors.forename: P
authors.initials: P
authors.lastname: Asai
authors.forename: U
authors.initials: U
authors.lastname: Khetan
authors.forename: I
authors.initials: I
authors.lastname: Akra
authors.forename: R G
authors.initials: RG
authors.lastname: Mendez
authors.forename: R
authors.initials: R
authors.lastname: Mendez
mesh_terms: D000328:Adult; D000367:Age Factors; D002784:Cholesterol / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects*; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000453:epidemiology*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015994:Incidence; D016030:Kidney Transplantation / Q000276:immunology* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced / Q000453:epidemiology*; D012189:Retrospective Studies; D012737:Sex Factors; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D005665:Furosemide; D016572:Cyclosporine; D002784:Cholesterol; D016559:Tacrolimus