Gastroduodenal permeability in Crohn's disease.
BACKGROUND
Gastric permeability was prospectively investigated by determination of sucrose excretion in 100 patients with Crohn's disease. Results were compared with histological findings and the lactulose-mannitol ratio as a measure of intestinal permeability.


METHODS
All subjects underwent oesophagogastroduodenoscopy with biopsies of all investigated parts. Thirty-two Helicobacter pylori-positive patients were excluded from further analyses.


RESULTS
Gastroduodenal permeability was significantly higher in patients with Crohn's disease than in control subjects (P < 0.00001). Sucrose excretion alone did not predict microscopic inflammation of the upper gastrointestinal tract. Increased gastroduodenal permeability with a concomitant rise in intestinal permeability predicted histological upper gastrointestinal involvement of Crohn's disease with a likelihood of 86%. The negative predictive value was 43%.


CONCLUSIONS
In parallel with findings in the small intestine, gastroduodenal permeability is increased in a high proportion of patients with Crohn's disease. In patients with an increased lactulose-mannitol ratio, elevated sucrose excretion is highly predictive of histological gastroduodenal involvement.
Püspök
A
A
Department of Gastroenterology and Hepatology, University of Vienna, Austria. andreas.puespoek@akh-wien.ac.at
Oberhuber
G
G
Wyatt
J
J
Maier-Dobersberger
T
T
Hammer
J
J
Pfeffel
F
F
Wrba
F
F
Pötzi
R
R
Vogelsang
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002463:Cell Membrane Permeability; D003424:Crohn Disease / Q000378:metabolism* / Q000473:pathology; D004386:Duodenum; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013395:Sucrose / Q000493:pharmacokinetics
D013395:Sucrose