A novel photoaffinity probe for the LTD4 receptor.
A novel photoaffinity probe for the leukotriene D4 receptor (LTD4) is described. L-745310, which is structurally related to the potent LTD4 antagonist MK-0476 (Singulair), was found to selectively label a 43-kDa protein in guinea-pig lung membrane previously identified as the LTD4 receptor.
Gallant
M
M
Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Québec, Canada.
Sawyer
N
N
Metters
K M
KM
Zamboni
R J
RJ
D000085:Acetates / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001389:Azirines; D003521:Cyclopropanes; D006168:Guinea Pigs; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D020024:Leukotriene Antagonists; D008168:Lung / Q000378:metabolism*; D008565:Membrane Proteins; D008970:Molecular Weight; D019920:Photoaffinity Labels; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism; D018077:Receptors, Leukotriene / Q000378:metabolism; D013440:Sulfides
D000085:Acetates; D001389:Azirines; D003521:Cyclopropanes; D007457:Iodine Radioisotopes; C111619:L 745310; D020024:Leukotriene Antagonists; D008565:Membrane Proteins; D019920:Photoaffinity Labels; D011804:Quinolines; D018077:Receptors, Leukotriene; D013440:Sulfides; C412375:cysteinyl leukotriene receptor 2; C083169:leukotriene D4 receptor; C093875:montelukast