title: Correlation between urinary epidermal growth factor excretion and serum thyroid hormone in premature and term neonates.
abstract: Eighty neonates, including 14 full-term, 31 premature, 27 twin or triplet, 6 small-for-gestational-age, and 2 infants with hyperthyroidism, were evaluated. The urinary epidermal growth factor/creatinine ratio (EGF/Cr) on the 1st postnatal day was not statistically different among full-term, premature, multiple-pregnancy, and small-for-gestational-age infants (F = 1.06, p = 0.6). There was no difference in urinary EGF/Cr between the 1st postnatal day and the 7th day (p = 0.4 by paired t test). The urinary EGF/Cr was not correlated with the serum thyroid-stimulating hormone level (r = -0.162, n = 60, p = 0.21), but showed a positive correlation with serum total T3 (r = 0.526, n = 60, p < 0.001) and with serum total T4 (r = 0.460, n = 60, p < 0.001). The correlation between urinary EGF/Cr and serum free T4 was even much better (r = 0.727, n = 25, p < 0.001). These results implicate that thyroid hormone may play a role in regulating urinary EGF excretion.
authors.affiliation: Department of Pediatrics, National Taiwan University Hospital, Taipei, Republic of China.
authors.forename: Y K
authors.initials: YK
authors.lastname: Tsau
authors.forename: R J
authors.initials: RJ
authors.lastname: Teng
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
mesh_terms: D003404:Creatinine / Q000652:urine; D004815:Epidermal Growth Factor / Q000652:urine*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000097:blood* / Q000652:urine*; D007234:Infant, Premature / Q000097:blood* / Q000652:urine*; D007236:Infant, Small for Gestational Age / Q000097:blood / Q000652:urine; D011247:Pregnancy; D011272:Pregnancy, Multiple; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D004815:Epidermal Growth Factor; D013972:Thyrotropin; D003404:Creatinine; D013974:Thyroxine