title: [From phylogenesis to physiology: dopamine receptors].
abstract: Communication between neurones requires specialised proteins called receptors which fix the neuromediator (e.g. dopamine) and transmit a message to the cell interior. For a given neuromediator there exist several types and subtypes of receptors, which make up multigenic families. These gene families have come to be thanks to successive duplications of one initial gene in the course of evolution. Thus dopamine receptors of the D1 class include up to four subtypes in vertebrates. The cloning and subsequent study of D1 genes in a sample of species representative of the major evolutionary stages in vertebrates has led to the localisation of the duplication phases of the genes at the origin of the functional diversity of these receptors.
authors.forename: J D
authors.initials: JD
authors.lastname: Vincent
mesh_terms: D000818:Animals; D014644:Genetic Variation; D010802:Phylogeny; D011954:Receptors, Dopamine / Q000145:classification / Q000235:genetics*; D017447:Receptors, Dopamine D1 / Q000235:genetics; D014714:Vertebrates / Q000235:genetics* / Q000502:physiology
chemical_list: D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1
vernacular_title: De la phylogénèse à la physiologie: à propos des récepteurs de la dopamine.