Neuroradiologic findings in Marinesco-Sjögren syndrome.
OBJECTIVE
Our purpose was to determine the neuroradiologic findings of Marinesco-Sjögren syndrome on plain skull radiographs, CT, and MR images.


METHODS
Eight patients with proved Marinesco-Sjögren syndrome (age range, 4 to 56 years) had a total of nine CT scans, seven MR imaging studies, and two plain radiographic examinations of the skull. The findings were reviewed retrospectively, with particular attention to the size of the posterior fossa and cerebellum.


RESULTS
All patients had hypoplastic cerebellar hemispheres and a hypoplastic vermis in a small posterior fossa. One patient had a midline posterior fossa cyst and another had agenesis of the corpus callosum.


CONCLUSIONS
Hypoplasia of the cerebellar hemispheres and the vermis and a small posterior fossa are the most prominent neuroradiologic findings in Marinesco-Sjögren syndrome.
Georgy
B A
BA
Department of Radiology, University of South Alabama College of Medicine, Mobile, USA.
Snow
R D
RD
Brogdon
B G
BG
Wertelecki
W
W
D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum; D002531:Cerebellum / Q000002:abnormalities / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D003337:Corpus Callosum / Q000473:pathology; D003388:Cranial Fossa, Posterior / Q000473:pathology; D003560:Cysts / Q000175:diagnosis / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013132:Spinocerebellar Degenerations / Q000175:diagnosis* / Q000235:genetics; D014057:Tomography, X-Ray Computed