Pharmacological investigation of oedema induced by venom from the wasp Polistes fuscatus.
Subplantar injection of Polistes fuscatus venom induced dose-dependent rat hindpaw oedema. The oedema was significant in the first hour and reached maximum size in the fifth hour after injection of the venom (20-600 micrograms/paw). Low doses of the venom (20-80 micrograms/paw) produced oedema which disappeared within 48 hr after injection, while at doses of 300-600 micrograms/paw, oedema was present in excess of 48 hr. Pharmacological studies suggested that P. fuscatus venom-induced oedema probably has a mechanism which is multimediated. Pretreatment of rats with a combination of cyproheptadine (5 mg/kg)-captopril (2 mg/kg)-dexamethasone (1 mg/kg) inhibited the formation of oedema (maximal swelling) produced by the venom (300 micrograms/paw) by about 79% and improved the time to recovery. Paw swellings caused by 20 and 40 micrograms/paw venom were completely eliminated by the same doses of this drug combination. The kinins, autacoids (histamine and serotonin) and lipogenase derivatives are probably involved in the venom-induced oedema.
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Department of Physiology, College of Medical Sciences, University of Calabar, Cross River State, Nigeria.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002216:Captopril / Q000627:therapeutic use; D003533:Cyproheptadine / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced* / Q000188:drug therapy; D006633:Histamine Antagonists / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000627:therapeutic use; D014862:Wasp Venoms / Q000633:toxicity*; D014863:Wasps
D000893:Anti-Inflammatory Agents; D006633:Histamine Antagonists; D012702:Serotonin Antagonists; D014862:Wasp Venoms; D003533:Cyproheptadine; D003907:Dexamethasone; D002216:Captopril