[Dipeptide nootropic agent GVS-111 prevents accumulation of the lipid peroxidation products during immobilization].
Immobilization of rats in a narrow plastic chamber for 24 h caused a sharp increase in the level of diene conjugates and the content of schiff bases in the synaptosomes of the brain cortex as well as accumulation of extraerythrocytic hemoglobin in blood serum. The dipeptide nootropic agent GVS-111 (ethyl ether of phenylacetylprolylglycine), when administered 15 and particularly 60 min before immobilization reduced the accumulation of these products of lipid peroxidation in the brain and blood. GVS-111 demonstrated these signs of its antioxidant effect after a single i.p. injection in doses of 0.12 and 0.5 mg/kg. Pyracetam produced a similar effect on the listed parameters in injection in a dose of 300 mg/kg for three successive days. The protective effect of the new pyracetam dipeptide analog GVS-111 in relation to activation of free-radical processes induced by immobilization is additional proof of the antistress action of this dipeptide.
Lysenko
A V
AV
Institute of Neurokibernetics, Rostov State Uneversity, Rostov-na-Donu, Russia.
Uskova
N I
NI
Ostrovskaia
R U
RU
Gudasheva
T A
TA
Voronina
T A
TA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D004151:Dipeptides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism
D004151:Dipeptides; D008055:Lipids; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly; D010889:Piracetam
Dipeptidnyĭ nootrop GVS-111 predotvrashchaet nakoplenie produktov perekisnogo okisleniia lipidov pri immobilizatsii.