[Management of diabetic vasculopathy].
The high prevalence rate of mortality in diabetic patients is explained by atherothrombotic cardiovascular disease. Hyperinsulinemia and insulin resistance, dyslipidemia, chronic hyperglycemia, decrease of endothelial cells and of monocytes-macrophage cell functions, and hypercoagulability are the main side-effects which are involved in the pathogenesis of diabetic atherothrombotic disease. Its clinical manifestations are coronary heart disease, peripheral vascular insufficiency, cerebral vascular insufficiency and reno-vascular hypertension. The common characteristics are a clinical latent period, the frequency of acute complications and the widespread bilateral distal localisation of vascular insufficiency. The therapeutic strategy in diabetic atherothrombotic disease is becoming better codified, leading to screening and prevention. The evaluation of diabetic vascular risk could reduce the prevalence of thrombotic events.
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Service d'Endocrinologie et de Diabétologie, Clinique Marc Linquette CHRU, Lille, France.
D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D012307:Risk Factors; D014652:Vascular Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy
Prise en charge de la vasculopathie diabétique.