title: Conservation of locus-specific microsatellite variability across species: a comparison of two Drosophila sibling species, D. melanogaster and D. simulans.
abstract: Fifteen microsatellite loci were studied in Drosophila melanogaster and Drosophila simulans, two closely related sibling species which split 2-3.5 MYA. Within-species variances in repeat number were found to differ up to 1,000-fold among individual microsatellite loci. A significant correlation of log variances between both species indicated a locus-specific mutation rate of microsatellites. Hence, locus-specific effects are apparently among the major forces influencing microsatellite variation and deserve more consideration in microsatellite analysis.
authors.affiliation: Institut für Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Harr
authors.forename: B
authors.initials: B
authors.lastname: Zangerl
authors.forename: G
authors.initials: G
authors.lastname: Brem
authors.forename: C
authors.initials: C
authors.lastname: Schlötterer
mesh_terms: D000349:Africa; D000818:Animals; D004330:Drosophila / Q000145:classification / Q000235:genetics*; D004331:Drosophila melanogaster / Q000145:classification / Q000235:genetics; D019143:Evolution, Molecular; D005819:Genetic Markers; D018895:Microsatellite Repeats; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D013045:Species Specificity
chemical_list: D005819:Genetic Markers