title: Punc, a novel mouse gene of the immunoglobulin superfamily, is expressed predominantly in the developing nervous system.
abstract: A search for genes regulated by the LlM/homeodomain transcription factor islet-1 during development identified the novel mouse gene punc (putative neuronal cell adhesion molecule). Punc is a member of the immunoglobulin superfamily, exhibits a novel configuration of four immunoglobulin domains and two fibronectin-type III repeats, and resembles proteins involved in axon guidance. Punc expression in the embryo occurs in restricted patterns in both the nervous system and limb mesoderm. A sharp decrease in punc expression after embryonic day 11.5 suggests a function for punc early in mouse embryogenesis.
authors.affiliation: The Neurosciences Institute, San Diego, CA 92121, USA.salbaum@nsi.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Salbaum
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000096:biosynthesis / Q000235:genetics*; D007136:Immunoglobulins / Q000096:biosynthesis / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009420:Nervous System / Q000196:embryology* / Q000378:metabolism
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D007136:Immunoglobulins; C112440:Punc protein, mouse