title: Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis.
abstract: The water extract of Biota orientalis showed a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets using [3H]PAF as a ligand in our previous screening studies for Korean medicinal antagonists by the activity-guided purification studies. Another active compound, compound 1 (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml, n = 4) was isolated from the title plant. The chemical structure of compound 1 was elucidated as pinusolidic acid by chemical and spectrometric analyses.
authors.forename: H O
authors.initials: HO
authors.lastname: Yang
authors.forename: B H
authors.initials: BH
authors.lastname: Han
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D001572:Benzofurans; D009281:Naphthalenes; D010972:Platelet Activating Factor; C111016:pinusolidic acid