title: Cell kinetic patterns in early gastric cancer.
abstract: Early gastric cancers (EGC) may be subdivided into 2 groups by means of the use of mitotic index, apoptotic index and cell density: EGCs with high cell turnover and low cell density, which show high cell dissociation and, more frequently, lymph node invasion; EGCs with low cell turnover and high cell density. The same parameters discriminate among intestinal type tumors, when separately considered from diffuse ones. No correlation is noted of these 2 groups with transforming growth factor-alpha, epidermal growth factor receptor and p53 expression, gross type, entity of neoangiogenesis, and submucosal invasion.
authors.affiliation: Institute of Pathological Anatomy and Histology, University of Siena, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Spina
authors.forename: C
authors.initials: C
authors.lastname: Miracco
authors.forename: C
authors.initials: C
authors.lastname: Vindigni
authors.forename: M
authors.initials: M
authors.lastname: Gallorini
authors.forename: L
authors.initials: L
authors.lastname: Presenti
authors.forename: D
authors.initials: D
authors.lastname: Marrelli
authors.forename: F
authors.initials: F
authors.lastname: Roviello
authors.forename: E
authors.initials: E
authors.lastname: Pinto
authors.forename: M I
authors.initials: MI
authors.lastname: Filipe
authors.forename: P
authors.initials: P
authors.lastname: Tosi
mesh_terms: D017209:Apoptosis; D002452:Cell Count; D006801:Humans; D008938:Mitosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D018809:Proliferating Cell Nuclear Antigen