title: MRI of laser-induced interstitial thermal injury in an in vivo animal liver model with histologic correlation.
abstract: Laser-induced interstitial thermal therapy (LITT) is a preferred method of minimally invasive therapy. MRI is a noninvasive method by which to monitor the thermal effects of LITT. To properly control such effects, changes in MRI parameters during and after LITT should be correlated with changes in the tissue. T1-weighted fast spin echo (FSE) MRI (1 image/10 seconds) at 1.5 T monitored LITT in vivo in rabbit liver (n = 6) using an interstitial bare delivery fiber (600-microm diameter; 3.0 W; 1,064 nm; 150 seconds). During laser irradiation, MRI signal intensity decreased around the fiber tip; after irradiation, this hypointensity proved reversible and permanent lesions were evident. The lesions had hyperintense margins that were brighter than surrounding normal tissue (P < .001); the tissue in these bright regions was mapped to tissue necrosis characterized by the presence of thermally damaged ghost red blood cells amid generally normal hepatocytes. T1-FSE identified the spatial extent of the LITT lesions.
authors.affiliation: Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. paul@bwh.harvard.edu
authors.forename: P R
authors.initials: PR
authors.lastname: Morrison
authors.forename: F A
authors.initials: FA
authors.lastname: Jolesz
authors.forename: D
authors.initials: D
authors.lastname: Charous
authors.forename: R V
authors.initials: RV
authors.lastname: Mulkern
authors.forename: S G
authors.initials: SG
authors.lastname: Hushek
authors.forename: R
authors.initials: R
authors.lastname: Margolis
authors.forename: M P
authors.initials: MP
authors.lastname: Fried
mesh_terms: D000818:Animals; D006979:Hyperthermia, Induced; D053685:Laser Therapy; D007834:Lasers / Q000009:adverse effects*; D008099:Liver / Q000293:injuries* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D011817:Rabbits