[New class of drugs for treatment of eye vascular diseases].
Hemolytic ocular film (HOF) represents a polymer-based "puff pastry" whose external layers contain antioxidant emoxipine and the internal layer contains an immobilized thrombolytic enzyme; such a structure ensures a successive multifunctional effect on the main components of pathogenesis: lipid peroxidation, local hemostasis, fibrinolysis, and immune system of patients with vascular abnormalities of the eyes. The drug was used in the treatment of 248 patients with intraocular hemorrhages of traumatic origin. Control group (150 patients with the same condition) was treated traditionally. Application of HOF resulted in complete or almost complete lysis of the blood in 95% of patients; in 5% the effect was null. Traditional therapy helped attain complete lysis of the blood in 9% and partial in 43% of patient; in 48% of patients the effect was null.
Travkin
A G
AG
Romashchenko
A D
AD
D000179:Acrylates; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005130:Eye Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D005131:Eye Injuries / Q000150:complications; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D010847:Picolines / Q000008:administration & dosage / Q000627:therapeutic use*; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use*; D015912:Thrombolytic Therapy / Q000379:methods*
D000179:Acrylates; D000975:Antioxidants; D005343:Fibrinolytic Agents; D010847:Picolines; D013300:Streptokinase; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Novyĭ klass lekarstvennykh veshchestv v lechenii sosudistoĭ patologii glaz]