[GABA-ergic system in defense against excitatory kynurenines].
Protection against the excitatory action of L-kynurenine and quinolinic acid in mice is related to the activation of GABA-B and dopamine receptors of the brain and to much lesser degree to the activation of GABA-A receptors. It is hardly believable that the anticonvulsant effect of phenibut (beta-phenyl-GABA), baclofen (CL-phenibut), sodium hydroxybutyrate and taurine against seizures induced by these two kynurenines is determined by alterations in metabolism of GABA.
Lapin
I P
IP
Bekhterev Psychoneurological Research Institute, Saint-Petersburg, Russia.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001418:Baclofen / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D018491:Dopamine Agonists / Q000494:pharmacology; D058785:GABA-A Receptor Agonists; D058786:GABA-B Receptor Agonists; D006885:Hydroxybutyrates / Q000494:pharmacology; D007276:Injections, Intraventricular; D007737:Kynurenine / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D017378:Quinolinic Acid / Q000008:administration & dosage / Q000633:toxicity; D013654:Taurine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*
D000927:Anticonvulsants; D018491:Dopamine Agonists; D058785:GABA-A Receptor Agonists; D058786:GABA-B Receptor Agonists; D006885:Hydroxybutyrates; D013654:Taurine; D007737:Kynurenine; D005680:gamma-Aminobutyric Acid; D017378:Quinolinic Acid; D001418:Baclofen; C008842:4-amino-3-phenylbutyric acid
GAMK-ergicheskaia sistema v zashchite ot vozbuzhdaiushchikh kinureninov.