title: Chromosomal translocation (1:13) in a case of alveolar rhabdomyosarcoma.
abstract: OBJECTIVE
  To describe a patient with a variant translocation (1;13)(p36;q14) in an alveolar rhabdomyosarcoma and compare the clinical course with four other cases.
  
  
  METHODS
  A 10-year-old girl presented with multiple masses involving the thigh, abdomen, chest wall, and scalp with pleural effusion and edema of the lower extremities.
  
  
  RESULTS
  A bone marrow biopsy, aspirate, and biopsy of the thigh mass all showed tumor invasion. Histopathology and cytogenetics of the thigh mass revealed an alveolar rhabdomyosarcoma with a t(1;13)(p36q14) variant. There was no response to aggressive therapy and the patient died within 3 weeks of admission.
  
  
  CONCLUSIONS
  Variant t(1;13)(p36;q14) has now been described in 5 cases of rhabdomyosarcoma, and may define a subset of patients with extensive disease at diagnosis unresponsive to current therapeutic modalities.
authors.affiliation: Pediatric Hemato-Oncology Department, The Chaim Sheba Medical Center, affiliated to the Sackler School of Medicine, Tel-Hashomer, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Kenet
authors.forename: N
authors.initials: N
authors.lastname: Sharon
authors.forename: E
authors.initials: E
authors.lastname: Rosner
authors.forename: A
authors.initials: A
authors.lastname: Toren
authors.forename: Y
authors.initials: Y
authors.lastname: Neumann
authors.forename: M
authors.initials: M
authors.lastname: Mandel
authors.forename: C
authors.initials: C
authors.lastname: Kaplinsky
authors.forename: N
authors.initials: N
authors.lastname: Gipsh
authors.forename: S
authors.initials: S
authors.lastname: Berman
authors.forename: G
authors.initials: G
authors.lastname: Rechavi
mesh_terms: D002648:Child; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D005260:Female; D006801:Humans; D018232:Rhabdomyosarcoma, Alveolar / Q000235:genetics*; D014178:Translocation, Genetic