title: Protein folds from pair interactions: a blind test in fold recognition.
abstract: We submitted nine predictions to CASP2 using our fold recognition program ProFIT. Two of these structures were still unsolved by the end of the experiment, six had a recognizable fold, and one fold was new. Four predictions of the six recognizable folds were correct. Two models were excellent in terms of alignment quality (T0031, T0004): in one the alignment was partially correct (T0014), and one fold was correctly identified (T0038). We discuss improvements of the program and analyze the prediction results.
authors.affiliation: Center for Applied Molecular Engineering, University of Salzburg, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Flöckner
authors.forename: F S
authors.initials: FS
authors.lastname: Domingues
authors.forename: M J
authors.initials: MJ
authors.lastname: Sippl
mesh_terms: D019747:Aldose-Ketose Isomerases / Q000737:chemistry; D000595:Amino Acid Sequence; D005083:Exfoliatins / Q000737:chemistry; D006597:Fructose-Bisphosphatase / Q000737:chemistry; D006836:Hydro-Lyases / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011117:Polyribonucleotide Nucleotidyltransferase / Q000737:chemistry; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D013913:Threonine Dehydratase / Q000737:chemistry
chemical_list: D005083:Exfoliatins; D011506:Proteins; D011117:Polyribonucleotide Nucleotidyltransferase; D006597:Fructose-Bisphosphatase; D006836:Hydro-Lyases; C020000:3-dehydroquinate dehydratase; D013913:Threonine Dehydratase; D019747:Aldose-Ketose Isomerases; C019714:D-arabinose isomerase