title: The effect of pre-operative administration of bupivacaine compared with its postoperative use.
abstract: Eighty patients undergoing lower third molar surgery under general anaesthesia were assigned to one of two groups to receive local anaesthetic blockade either 10 min prior to surgery or after surgery just before leaving the operating theatre. Patients in both groups received the local anaesthetic block whilst unconscious. Pain was assessed using visual analogue scales at 6 h and 1, 3 and 6 days after surgery. A McGill Pain Questionnaire was also completed on the morning following surgery. At no time was it possible to detect any significant difference in pain between the two groups. The administration of local anaesthesia prior to starting surgery does not appear to have any advantage over its postoperative administration in patients undergoing this type of surgery. The local anaesthetic, however, does provide excellent analgesia during the first few hours following surgery.
authors.affiliation: Department of Anaesthesia, Ulster Hospital, UNDAH Trust, Dundonald, Belfast, UK.
authors.forename: W I
authors.initials: WI
authors.lastname: Campbell
authors.forename: R W
authors.initials: RW
authors.lastname: Kendrick
authors.forename: P
authors.initials: P
authors.lastname: Ramsay-Baggs
authors.forename: W
authors.initials: W
authors.lastname: McCaughey
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental; D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000627:therapeutic use; D002045:Bupivacaine / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D014081:Tooth Extraction
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine