title: [Intrabronchial curietherapy. Experiences at Hôpital Saint-Louis after the treatment of 149 patients].
abstract: Endobronchial tumour obstruction threatens to occur in cases of carcinoma of the bronchus throughout the course of the disease. Such patients can benefit from relief of the bronchial obstruction by several techniques which are currently available. We have treated 149 patients with endobronchial radiotherapy. Seventy three patients were treated with a view to cure, 47 with a palliative dose and 29 received endobronchial radiation in complement with external irradiation. The treatment was carried out in series repeated every 15 days until a maximum of three treatments, consisting of two sessions at 24 hour intervals delivering at each session and irradiating of 7 Gy with a 1 cm catheter. All the clinical signs were relieved and in 79% of patients there was a symptomatic benefit. One hundred and thirty two patients were evaluated by control endoscopy two months after the treatment and 64 had a complete histological remission. The median survival was 14.4 months for patients treated with intent to cure. Obtaining a histological remission was a gauge for prolonged survival (median survival 26.5 months), 11 (7.4%) had massive hemoptysis and 13 (8%) irradiation pneumonitis, all of which occurred some time after the therapeutic procedure. The results confirm the feasibility and the good results of endobronchial irradiation in this field and encourage the idea of controlled multi-centre trials in order to assess a placed of endobronchial radiotherapy in the therapeutic strategy of bronchial cancer.
authors.affiliation: Service de Pneumologie, Hôpital Saint-Louis, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Trédaniel
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
authors.forename: G
authors.initials: G
authors.lastname: Zalcman
authors.forename: D
authors.initials: D
authors.lastname: Gossot
authors.forename: F
authors.initials: F
authors.lastname: Lavergne
authors.forename: P
authors.initials: P
authors.lastname: Colin
authors.forename: D
authors.initials: D
authors.lastname: Manoux
authors.forename: M
authors.initials: M
authors.lastname: Perret
authors.forename: F
authors.initials: F
authors.lastname: Gerber
authors.forename: C
authors.initials: C
authors.lastname: Maylin
authors.forename: A
authors.initials: A
authors.lastname: Hirsch
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary; D000402:Airway Obstruction / Q000532:radiotherapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001918:Brachytherapy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D001984:Bronchial Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D001999:Bronchoscopy; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary; D003131:Combined Modality Therapy; D018849:Controlled Clinical Trials as Topic; D003452:Cryosurgery; D019583:Dose Fractionation, Radiation; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010166:Palliative Care; D011013:Pneumonectomy; D017564:Radiation Pneumonitis / Q000209:etiology; D011879:Radiotherapy Dosage; D012074:Remission Induction; D015996:Survival Rate
vernacular_title: Curiethérapie endobronchique. L'expérience de l'Hôpital Saint-Louis après le traitement de 149 patients.