In vivo investigations of vascular density and local mitochondrial metabolism after irradiation.
It is obvious that irradiation increases local oxygen uptake. Because the oxygen supply is not altered, a decrease in local oxygen partial pressure may develop. This state may be called relative hypoxia. If the metabolism is altered for a period of at least 24 hrs an increase in angiogenic mitogens, inducing angiogenesis will occur. Presumably this is the mechanism underlying the therapeutic effect of radiotherapy in benign disease.
Plasswilm
L
L
Klinik und Poliklinik für Strahlentherapie, Universität Erlangen-Nürnberg, Germany.
Höper
J
J
D000818:Animals; D002642:Chick Embryo; D003124:Colorimetry; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism / Q000528:radiation effects*; D018919:Neovascularization, Physiologic / Q000528:radiation effects*; D013997:Time Factors; D015017:Yolk Sac / Q000098:blood supply* / Q000378:metabolism