title: Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis: in vivo evidence of a role for nerve growth factor.
abstract: Proliferating cells in the subventricular zone (SVZ) of adult rat brain could provide a source of cells for repair attempts during degenerative diseases. However, very few reports dealt with the spontaneous regulation of this cell population during experimental conditions. In this paper, we describe an increase in the proliferation activity in the SVZ during experimental allergic encephalomyelitis, a demyelinating disease widely used as an experimental model for human multiple sclerosis. Moreover, p75(LNGFR)-immunoreactive elements in the SVZ were larger in experimental allergic encephalomyelitis compared with control groups, and they also showed multiple and branched elongations. Finally, a selective uptake of 125I-nerve growth factor was observed in the SVZ in neonatal rats, and positive elements migrated in the corpus callosum within a few days. These data indicate that cell populations in the SVZ are regulated during inflammatory conditions and degenerative diseases involving oligodendrocytes and neurotrophins, including nerve growth factor, could participate in these phenomena.
authors.affiliation: Department of Biochemistry and Human Physiology, University of Cagliari, 09124 Cagliari, Italy. cefisnmo@mbox.vol.it
authors.forename: L
authors.initials: L
authors.lastname: Calzà
authors.forename: L
authors.initials: L
authors.lastname: Giardino
authors.forename: M
authors.initials: M
authors.lastname: Pozza
authors.forename: C
authors.initials: C
authors.lastname: Bettelli
authors.forename: A
authors.initials: A
authors.lastname: Micera
authors.forename: L
authors.initials: L
authors.lastname: Aloe
mesh_terms: D000818:Animals; D001324:Autoantigens; D015415:Biomarkers; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D002552:Cerebral Ventricles / Q000166:cytology* / Q000378:metabolism*; D003337:Corpus Callosum / Q000166:cytology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism*; D005260:Female; D009414:Nerve Growth Factors / Q000378:metabolism*; D009687:Nuclear Proteins / Q000302:isolation & purification; D009830:Olfactory Bulb / Q000378:metabolism; D010641:Phenotype; D046988:Proteasome Endopeptidase Complex; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis; D051381:Rats; D011917:Rats, Inbred Lew; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis; D020800:Receptor, Nerve Growth Factor; D020917:Receptor, trkA; D017475:Receptors, Nerve Growth Factor / Q000096:biosynthesis / Q000302:isolation & purification
chemical_list: D001324:Autoantigens; D015415:Biomarkers; C099558:Ki antigen; D009414:Nerve Growth Factors; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D020917:Receptor, trkA; D046988:Proteasome Endopeptidase Complex