title: Mediators of inflammation.
abstract: Therapeutic studies and genetically engineered animals have elucidated the inflammatory roles of cytokines and chemokines in autoimmune disease. Most unexpected has been a continuum of recent evidence demonstrating that inflammatory mediators are crucial in lymphoid organ development, thus suggesting that these hitherto unrelated processes have common elements with implications for determinant spreading.
authors.affiliation: Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06520-8034, USA.
authors.forename: R
authors.initials: R
authors.lastname: Sacca
authors.forename: C A
authors.initials: CA
authors.lastname: Cuff
authors.forename: N H
authors.initials: NH
authors.lastname: Ruddle
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines