Cost-effectiveness of posttreatment surveillance after radiation therapy for early stage seminoma.
BACKGROUND
This study evaluated the cost-effectiveness of posttreatment surveillance after radiation therapy for early stage seminoma.


METHODS
From 1988-1995, 47 patients with Stage I, and 11 patients with Stage II seminoma (based on the Royal Marsden staging system) received paraaortic and pelvic lymph node radiation after radical orchiectomy. Patient records were reviewed and patients surveyed to determine the tests ordered for posttreatment surveillance.


RESULTS
With a median follow-up of 55 months, there were 2 recurrences among the 58 patients. Eight-year actuarial disease free survival was 93%, with 100% overall survival. Information concerning follow-up screening was available for 56 patients. The follow-up tests ordered included 842 physical examinations, 815 chest X-rays, 839 serum markers, 250 computerized tomography scans, and 112 abdominal plain films. The total cost of these examinations according to 1996 private sector charges and 1996 Medicare reimbursement rates, respectively, was $602,673.01 (average $10,762.02 per patient) and $282,746.52 (average $5049.05 per patient). The two patients who experienced recurrence were diagnosed independently of their posttreatment screening program. One patient recurred 7.5 months after his original diagnosis with an isolated spinal cord compression. The second patient had a mediastinum recurrence > 6 years after treatment. At last follow-up, both patients were disease free after salvage treatment.


CONCLUSIONS
Patients with early stage seminoma treated with orchiectomy and radiation have excellent disease free survival rates. The cost of the surveillance program studied does not appear to be justifiable.
Buchholz
T A
TA
Department of Radiation Oncology, M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Walden
T L
TL
Prestidge
B R
BR
D000328:Adult; D003131:Combined Modality Therapy; D003362:Cost-Benefit Analysis; D019937:Diagnostic Techniques and Procedures / Q000191:economics*; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D009919:Orchiectomy; D018239:Seminoma / Q000191:economics* / Q000532:radiotherapy* / Q000601:surgery; D013736:Testicular Neoplasms / Q000191:economics* / Q000532:radiotherapy* / Q000601:surgery