Comparative efficacy and safety of terfenadine with pseudoephedrine and terfenadine alone in allergic rhinitis.
A randomized, double-blind clinical trial was conducted on 41 adult patients to compare the efficacy and safety of the combination of terfenadine and pseudoephedrine with that of terfenadine alone. Efficacy of treatment evaluated by the physician and patients showed an excellent rating in 45.45% patients in the combination treatment group compared with an excellent rating in 10.53% in the single treatment group. The difference between both treatments was statistically significant, with a z value of 1.660 (p < 0.05). The combination of terfenadine and pseudoephedrine was found to result in faster relief in a greater number of patients than terfenadine alone. However, both drugs were well tolerated.
Panda
N K
NK
Department of Otolaryngology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Mann
S B
SB
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004809:Ephedrine / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D014663:Nasal Decongestants / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D016593:Terfenadine / Q000627:therapeutic use*; D016896:Treatment Outcome
D006634:Histamine H1 Antagonists; D014663:Nasal Decongestants; D016593:Terfenadine; D004809:Ephedrine