[Serum creatine kinase MM isoforms and lactate dehydrogenase isoenzymes in patients with non-traumatic acute rhabdomyolysis].
We studied lactate-dehydrogenase (LD) isoenzymes and creatinekinase MM (CKMM) isoforms MM1, MM2 and MM3, in the serum of 18 patients with nontraumatic acute rhabdomyolysis, to test the utility of these markers in the diagnosis and disease evolution. The isoenzymes were separated by electrophoresis on agarose gel and were quantified with a densitometer. We studied the correlation between CKMM isoforms calculating the MM3/MM1 ratio, establishing the reference values from control group of 36 healthy adults. MM3 and MM3/MM1 ratio values were significantly increased in patients with rhabdomyolysis (p < 0.001) and progressively decreased coinciding with signs of getting better, showing 10 days after similar values of control group. LD4 and LD5 isoenzymes were significantly increased (p < 0.001) keeping elevated until 8-10 days when they showed a significant decrease compared with admission values (p < 0.05) but keeping elevated respect to control (p < 0.01).
Sanchez Navarro
M R
MR
Departamento de Bioquímica, Hospital Universitario San Cecilio, Granada.
Wangensteen Fuentes
R
R
Oliver Almendros
C
C
D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000097:blood* / Q000503:physiopathology
D015415:Biomarkers; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase
Isoformas de creatin quinasa-MM e isoenzimas de lactico deshidrogenasa en el suero de pacientes con rabdomiolisis aguda no traumática.