Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism.
Antiepileptic drug-induced reductions in serum levels of biologically active testosterone and elevations in serum estradiol (E2) may contribute to sexual dysfunction among men with epilepsy. Treatment using a combination of testosterone and the aromatase inhibitor testolactone may have significantly better effects on sexual function and also seizure frequency than testosterone alone.
Herzog
A G
AG
Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Klein
P
P
Jacobs
A R
AR
D000328:Adult; D047072:Aromatase Inhibitors; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D004827:Epilepsy / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D004958:Estradiol / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012098:Reproduction / Q000187:drug effects*; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy* / Q000209:etiology; D013738:Testolactone / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood / Q000627:therapeutic use*; D016896:Treatment Outcome
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D013739:Testosterone; D004958:Estradiol; D013738:Testolactone