The patched gene in development and cancer.
The cloning of vertebrate homologues of the Drosophila segment polarity gene patched has led to confirmation of a role for the multipass transmembrane protein which it encodes as a receptor for secreted signalling proteins of the Hedgehog family. In addition, human patched has been identified as a tumour suppressor gene implicated in basal cell carcinomas and medullablastomas.
Ingham
P W
PW
Developmental Genetics Programme, Krebs Institute, University of Sheffield, UK. p.w.ingham@sheffield.ac.uk
D000818:Animals; D001478:Basal Cell Nevus Syndrome / Q000235:genetics; D002280:Basal Cell Carcinoma / Q000235:genetics*; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D006801:Humans; D019476:Insect Proteins / Q000378:metabolism; D008527:Medulloblastoma / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D009154:Mutation; D000072079:Patched Receptors; D011956:Receptors, Cell Surface; D015398:Signal Transduction; D014714:Vertebrates / Q000254:growth & development*
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D000072079:Patched Receptors; D011956:Receptors, Cell Surface; C077245:hh protein, Drosophila