[Hep-A-in-Vac, a Russian cultured concentrated inactivated vaccine against hepatitis A].
The results of the study of the reactogenicity, safety and immunological activity of Russian cultural vaccine against hepatitis A are presented. The vaccine was found to have specific safety, moderate reactogenicity and pronounced immunological activity. In addition, the study of the prophylactic efficiency of the vaccine in the pre-epidemic period of the outbreak of hepatitis A morbidity in a group exceeding 14,000 adults was carried out. The study revealed high prophylactic efficiency of the vaccine (its efficiency rate was equal to 97.7%). On the basis of materials thus obtained vaccine "Hep-A-in-Vac" was recommended for use in medical practice for the prophylaxis of hepatitis A among adults.
Gorbunov
M A
MA
Tarasevich State Research Institute for Standartization and Control of Medical Biological Preparations, Moscow, Russia.
Pavlova
L I
LI
Rozhkov
S D
SD
Kukharev
A I
AI
Novikov
V Iu
VIu
Karpovich
L G
LG
Kalashnikova
T V
TV
Bektimirov
T A
TA
Zelenov
I A
IA
Levina
V D
VD
Belashev
B P
BP
Ermolaeva
T N
TN
Doroshenko
N V
NV
Maĭdaniuk
A T
AT
D000293:Adolescent; D000328:Adult; D006506:Hepatitis A / Q000453:epidemiology / Q000517:prevention & control*; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology; D006801:Humans; D008297:Male; D012426:Russia / Q000453:epidemiology; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000009:adverse effects / Q000276:immunology*
D006508:Hepatitis Antibodies; D017325:Hepatitis B Vaccines; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines
Izuchenie otechestvennoĭ kul'tural'noĭ kontsentrirovannoĭ inaktivirovannoĭ vaktsiny protiv gepatita A "Gep-A-in-Vak".