title: Elevation in plasma alkaline phosphatase level during rhG-CSF administration. Granulocytopenic patients with gynecologic cancers treated with cancer chemotherapy.
abstract: Neutropenic patients suffering from gynecologic cancers treated with cancer chemotherapy were evaluated to investigate changes in levels of plasma alkaline phosphatase (ALP) during recombinant human granulocyte colony stimulating factor (rhG-CSF) administration, and to discern its causes. Plasma ALP, ALP isozymes, neutrophil alkaline phosphatase (NAP) activity, and morphological maturation of neutrophils were measured prior to, during, and after rhG-CSF administration. Plasma ALP values were significantly elevated (p < 0.05) during administration of rhG-CSF. ALP-3, the dominant alkaline phosphatase fraction of NAP, was the dominant isozyme that showed an increase in the plasma. Moreover, the elevation of plasma ALP-3 significantly correlated with the elevation of NAP activity (r = 0.939, p < 0.0001), and neutrophils in which NAP activity was induced were not limited to morphologically mature neutrophils. These results showed that rhG-CSF acts to stimulate neutrophils at all stages of maturation and causes an elevation of plasma ALP(ALP-3) concentrations in plasma.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fukumasu
authors.forename: Y
authors.initials: Y
authors.lastname: Fukumasu
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016889:Endometrial Neoplasms / Q000188:drug therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000201:enzymology* / Q000628:therapy; D009504:Neutrophils / Q000201:enzymology / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy; D011994:Recombinant Proteins
chemical_list: D000970:Antineoplastic Agents; D007527:Isoenzymes; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000469:Alkaline Phosphatase