Activin and bone morphogenetic protein (BMP) signalling during tooth development.
Activins and bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related cytokines. Results of recent in vivo and in vitro studies suggest that activin A, several BMPs, and their cell surface receptors may participate in tooth development. In addition, follistatin an extracellular protein that may interact with activin and BMP signaling, appears to be involved. This review focuses on recent advances in relation to the roles of activin/BMP receptors, their ligands and extracellular modifiers during tooth development.
Heikinheimo
K
K
Institute of Dentistry, University of Turku, Finland. heikinhe@netlife.fi
Bègue-Kirn
C
C
Ritvos
O
O
Tuuri
T
T
Ruch
J V
JV
D029404:Activin Receptors; D028341:Activins; D000818:Animals; D052004:Bone Morphogenetic Protein Receptors; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000502:physiology*; D038681:Follistatin; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins / Q000235:genetics / Q000502:physiology; D066298:In Vitro Techniques; D007265:Inhibins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009805:Odontogenesis / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
D019485:Bone Morphogenetic Proteins; D038681:Follistatin; D006023:Glycoproteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D017978:Receptors, Growth Factor; D028341:Activins; D007265:Inhibins; D029404:Activin Receptors; D052004:Bone Morphogenetic Protein Receptors