title: Epidemiological survey of Neisseria meningitidis susceptibility to penicillin G in France.
abstract: The susceptibility of 82 strains of Neisseria meningitidis to penicillin G and amoxicillin was evaluated with two media "gonococci-meningococci" medium (G medium) derived from Mueller Hinton and chocolate agar. Among these 82 strains 52 were isolated from CSF and/or blood and 30 from miscellaneous isolates. G medium was compared with chocolate agar using the correlation between diameters and MIC and the E-test. Routinely standardised antibiogram is still used but the authors added the following techniques 1) MIC of penicillin G is tested (0.06; 0.125; 0.250; 0.50 mg/l); 2) use of oxacillin disc charged with 5 micrograms. Penicillinase producing meningococci were not found. Standardised antibiogram on 4192 strains resulted in a modal distribution of diameters between 18 to 40 mm. Moderate meningococci susceptible strains to penicillin G are increasing in France: 1994: 4%; 1995: 11%; 1996: 18%.
authors.affiliation: Centre National de Référence des Méningocoques (CNRM), Unité des Neisseria, Institut Pasteur, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Guibourdenche
authors.forename: T
authors.initials: T
authors.lastname: Lambert
authors.forename: P
authors.initials: P
authors.lastname: Courvalin
authors.forename: J Y
authors.initials: JY
authors.lastname: Riou
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D003470:Culture Media; D005602:France / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D009345:Neisseria meningitidis / Q000187:drug effects*; D010400:Penicillin G / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology
chemical_list: D003470:Culture Media; D010406:Penicillins; D000658:Amoxicillin; D010400:Penicillin G