title: Successful use of intravenous immunoglobulins in Landau-Kleffner syndrome.
abstract: A detailed history of a boy with Landau-Kleffner syndrome is presented, demonstrating a close relationship between language functioning and paroxysmal electroencephalogram activity. During a 3-year 6-month follow-up period, three abrupt deteriorations of all language functions occurred: the child became totally noninteractive with his environment within 1 week's time. Two of these deteriorations were reversed with steroid treatment, with an identical recovery phase. Intravenous immunoglobulins had a very dramatic and comparable effect in the third relapse; both language functions and electroencephalogram abnormalities were influenced significantly by the intravenous immunoglobulin treatment.
authors.affiliation: University Hospital Gasthuisberg; Department of Pediatrics; Leuven, Belgium.
authors.forename: L G
authors.initials: LG
authors.lastname: Lagae
authors.forename: J
authors.initials: J
authors.lastname: Silberstein
authors.forename: P L
authors.initials: PL
authors.lastname: Gillis
authors.forename: P J
authors.initials: PJ
authors.lastname: Casaer
mesh_terms: D002648:Child; D004569:Electroencephalography; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D018887:Landau-Kleffner Syndrome / Q000150:complications / Q000628:therapy*; D007806:Language Disorders / Q000209:etiology / Q000628:therapy; D008297:Male; D009483:Neuropsychological Tests
chemical_list: D016756:Immunoglobulins, Intravenous