Neurotoxicodynamics of the interaction between ciprofloxacin and foscarnet in mice.
The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of gamma-aminobutyric acid (GABA)-GABA(A) receptor binding in the presence of PFA.
Matsuo
H
H
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Ryu
M
M
Nagata
A
A
Uchida
T
T
Kawakami
J I
JI
Yamamoto
K
K
Iga
T
T
Sawada
Y
Y
D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D000998:Antiviral Agents / Q000633:toxicity*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002939:Ciprofloxacin / Q000633:toxicity*; D004347:Drug Interactions; D017245:Foscarnet / Q000633:toxicity*; D008297:Male; D051379:Mice; D018079:Receptors, GABA / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced
D000890:Anti-Infective Agents; D000998:Antiviral Agents; D018079:Receptors, GABA; D017245:Foscarnet; D002939:Ciprofloxacin