[Possibility of using saliva for therapeutic monitoring of digoxin].
Digoxin in salvia and blood serum of 24 patients obtained Bemecor was determined by the method of FPIA (IMx-ABBOT). Mixed saliva was collected by three different types of Salivette (Sarstedt) given in order: normal Salivette with cotton wool swab, Slivette with polyester wool and Salivette with citric acid as a stimulator. It was found, that the correletio between the digoxin concentrations in saliva and serum and saliva/serum rations depended on the type of Salivette. The highest correlation was obtained with the Salivette with polyester wool (r = 0.892), but low concentrations of this drug in serum were good reflected in all samples of saliva, independent on kind of Salivette.
Tadeusiak
W
W
Zakładu Diagnostyki Laboratoryjnej CMKP, Warszawie.
Marcinowska-Suchowierska
E
E
Podleśny
J
J
Andrzejewski
A
A
D004077:Digoxin / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008520:Medigoxin / Q000008:administration & dosage / Q000378:metabolism; D012463:Saliva / Q000737:chemistry*; D013048:Specimen Handling / Q000379:methods*
D004077:Digoxin; D008520:Medigoxin
Mozliwość zastosowania śliny do terapii monitorowanej digoksyny.