Role of B-cell and Fc receptors in the selection of T-cell epitopes.
The role of specific receptors in antigen internalization and presentation to helper T lymphocytes has been known for more than ten years. However, recent work indicates that internalization may not always be sufficient for antigen presentation. Indeed, antigen receptors such as B-cell receptors and Fc receptors may also be involved in the post-endocytic transport events that determine selectively the delivery of antigens to different endocytic compartments and thereby the presentation of different T-cell epitopes.
Amigorena
S
S
Institut Curie, INSERM, Paris, France. s.amigorena@curie.fr
Bonnerot
C
C
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D011947:Receptors, Antigen, B-Cell; D011961:Receptors, Fc