Effects of aluminum hydroxide and famotidine on bioavailability of tosufloxacin in healthy volunteers.
This study was designed to determine the influence of aluminum hydroxide and famotidine on the bioavailability of tosufloxacin. Coadministration of aluminum hydroxide reduced the bioavailability of tosufloxacin by 31.6% (P < 0.05). Famotidine did not alter tosufloxacin absorption. To avoid potential treatment failures, the concurrent use of tosufloxacin and aluminum hydroxide should be avoided altogether.
Minami
R
R
Department of Pharmaceutical Services, Kumamoto University Hospital, Honjo, Japan.
Nakamura
C
C
Inotsume
N
N
Nakano
M
M
D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001682:Biological Availability; D004347:Drug Interactions; D015738:Famotidine / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D009287:Naphthyridines / Q000097:blood / Q000493:pharmacokinetics*
D000863:Antacids; D000890:Anti-Infective Agents; D000897:Anti-Ulcer Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D000536:Aluminum Hydroxide; D015738:Famotidine; C055185:tosufloxacin