Apo E isoforms, insulin output and plasma lipid levels in essential hypertension.
BACKGROUND
The association between apo E isoforms and insulin output during the oral glucose test (OGTT) in 60 non-diabetic, non-obese patients with essential hypertension and in control subjects (non-obese, non-diabetic normotensive subjects) was estimated.


METHODS
According to low or high insulin output during OGTT, the subjects were divided into the following groups: normotensive subjects with low (NLI) and high (NHI) and hypertensive subjects with low (HLI) and high (HHI) insulin output.


RESULTS
The apo E 4/2 phenotype was detected in 32% of hypertensive subjects but not in control subjects. The frequency of apo E 3/2 phenotype in hypertensive subjects was 5% and in normotensive subjects 15%. An increased frequency of phenotype apo E 4/3 was noticed both in HHI (46%) and in NHI (50%) compared with HLI (22%) and NLI (17%) groups.


CONCLUSIONS
The results suggest that the determination of phenotypes apo E and insulin output may contribute to an early detection of individuals at high risk of hypertension development.
Dembińska-Kieć
A
A
Collegium Medicum, Jagiellonian University, Cracow, Poland. mbkiec@cyf-kr.edu.pl
Kawecka-Jaszcz
K
K
Kwaśniak
M
M
Guevara
I
I
Pankiewicz
J
J
Malczewska-Malec
M
M
Iwanejko
J
J
Hartwich
J
J
Zdzienicka
A
A
Stochmal
A
A
Leszczyńska-Gołabek
I
I
D000328:Adult; D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000097:blood* / Q000235:genetics; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D001057:Apolipoproteins E; D007328:Insulin; D008055:Lipids