[Effect of baclofen on calcium channel currents in dorsal sensory cells of the lamprey spinal cord].
delta-Baclofen reduced the peak amplitude of the barium current in the DSCs from Lunicuspis and L.fluviatilis. The membrane conductance was not altered either by baclofen or GABA. The reducing effect could be abolished with delta-aminovaleric acid or 2(OH)saclofen. The data obtained suggest presence of the GABAB receptors in the DSC membranes. Functional role of the GABAB receptors in primary afferent cells of cyclostomes, is discussed.
Batueva
I V
IV
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg, Russia.
Buchanan
J T
JT
Tsvetkov
E A
EA
Sagatelian
A K
AK
Veselkin
N P
NP
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001464:Barium / Q000378:metabolism; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D018755:GABA Agonists / Q000494:pharmacology*; D018756:GABA Antagonists / Q000494:pharmacology; D058787:GABA-A Receptor Antagonists; D058788:GABA-B Receptor Antagonists; D066298:In Vitro Techniques; D007798:Lampreys; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D018408:Patch-Clamp Techniques; D018080:Receptors, GABA-B / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D015220:Calcium Channels; D018755:GABA Agonists; D018756:GABA Antagonists; D058787:GABA-A Receptor Antagonists; D058788:GABA-B Receptor Antagonists; D018080:Receptors, GABA-B; D001464:Barium; D005680:gamma-Aminobutyric Acid; D001418:Baclofen
Vliianie baklofena na tok kal'tsievykh kanalov v dorsal'nykh chuvstvitel'nykh kletkakh spinnogo mozga minogi.