title: Spiral CT during pharmacoangiography with angiotensin II in patients with pancreatic disease. Technique and diagnostic efficacy.
abstract: OBJECTIVE
  To compare the diagnostic efficacy of pancreatic pharmacoangiographic CT using angiotensin II with conventional angiographic CT.
  
  
  METHODS
  Eighteen patients with space-occupying pancreatic disease were examined in this study. Pharmacoangiographic CT was performed with a 1-3 micrograms/6-ml solution of angiotensin II injected through a catheter into the celiac artery during spiral CT.
  
  
  RESULTS
  In 17 of the 18 (94%) patients, the area of pancreatic parenchymal enhancement was the same or larger at pharmacoangiographic CT than at conventional angiographic CT. The attenuation value of the pancreatic parenchyma was significantly increased at pharmacoangiographic CT (p = 0.0010). Although the attenuation value of tumors was also increased on images obtained after the injection of angiotensin II, the tumor-to-pancreas contrast was significantly greater at pharmacoangiographic CT (p = 0.0479). The mean differences in attenuation between tumor and pancreas at angiographic CT with and without angiotensin II were respectively 182 HU and 115 HU.
  
  
  CONCLUSIONS
  Pharmacoangiographic CT with angiotensin II proved superior to conventional angiographic CT in the diagnosis of pancreatic disease. We therefore recommend it as a supplementary technique at the angiographic examination of patients with suspected pancreatic tumor.
authors.affiliation: Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Kuroda
authors.forename: N
authors.initials: N
authors.lastname: Mihara
authors.forename: N
authors.initials: N
authors.lastname: Hosomi
authors.forename: E
authors.initials: E
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Ohigashi
authors.forename: O
authors.initials: O
authors.lastname: Ishikawa
authors.forename: A
authors.initials: A
authors.lastname: Nakaizumi
authors.forename: S
authors.initials: S
authors.lastname: Ishiguro
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D000804:Angiotensin II; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000098:blood supply / Q000000981:diagnostic imaging*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D010195:Pancreatitis / Q000000981:diagnostic imaging*; D012039:Regional Blood Flow / Q000187:drug effects; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D000804:Angiotensin II