title: Interferon beta normalizes suppressor cell function in dysimmune neuropathies.
abstract: We found a defective suppressor cell function in vitro both in idiopathic chronic inflammatory demyelinating polyneuropathy and in paraproteinemic neuropathy with antibodies to sulfated glucuronyl paragloboside. In the presence of interferon beta, suppressor cell function was normalized. Our results suggest that a decreased suppressor cell function plays a pathogenetic role in dysimmune neuropathies. Interferon beta might represent an adjunctive therapy in CIDP both acting on a defective blood-nerve barrier and normalizing an otherwise defective suppressor cell function.
authors.affiliation: Center for Neuromuscular Diseases, Department of Oncology and Neurosciences of the University of Chieti, Policlinico Clinicizzato `Colle Dell'Ara', I-66013 Chieti, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: De Luca
authors.affiliation: Center for Neuromuscular Diseases, Department of Oncology and Neurosciences of the University of Chieti, Policlinico Clinicizzato `Colle Dell'Ara', I-66013 Chieti, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Lugaresi
authors.affiliation: Center for Neuromuscular Diseases, Department of Oncology and Neurosciences of the University of Chieti, Policlinico Clinicizzato `Colle Dell'Ara', I-66013 Chieti, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Iarlori
authors.affiliation: Center for Neuromuscular Diseases, Department of Oncology and Neurosciences of the University of Chieti, Policlinico Clinicizzato `Colle Dell'Ara', I-66013 Chieti, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Marzoli
authors.affiliation: Center for Neuromuscular Diseases, Department of Oncology and Neurosciences of the University of Chieti, Policlinico Clinicizzato `Colle Dell'Ara', I-66013 Chieti, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Uncini
authors.affiliation: Center for Neuromuscular Diseases, Department of Oncology and Neurosciences of the University of Chieti, Policlinico Clinicizzato `Colle Dell'Ara', I-66013 Chieti, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Gambi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000097:blood; D002648:Child; D003711:Demyelinating Diseases / Q000276:immunology / Q000628:therapy*; D005260:Female; D005915:Globosides / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016899:Interferon-beta / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D010265:Paraproteinemias / Q000276:immunology / Q000628:therapy*; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000628:therapy*; D011115:Polyneuropathies / Q000276:immunology / Q000628:therapy; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D005915:Globosides; D007075:Immunoglobulin M; D018992:Myelin-Associated Glycoprotein; D011994:Recombinant Proteins; C051917:sulfate-3-glucuronyl paragloboside; D016899:Interferon-beta