title: Inheritance of chronic tension-type headache investigated by complex segregation analysis.
abstract: We investigated the mode of inheritance of chronic tension-type headache in 122 families. The probands were from the Copenhagen Headache Clinic, Denmark. The criteria of the International Headache Society were used. The patterns of segregation of chronic tension-type headache were assessed by complex segregation analysis performed with the computer program POINTER. Of the 122 probands with chronic tension-type headache, 56 had 71 first-degree relatives with chronic tension-type headache. The complex segregation analysis indicates that chronic tension-type headache has multifactorial inheritance.
authors.affiliation: Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: M B
authors.initials: MB
authors.lastname: Russell
authors.forename: L
authors.initials: L
authors.lastname: Iselius
authors.forename: S
authors.initials: S
authors.lastname: Ostergaard
authors.forename: J
authors.initials: J
authors.lastname: Olesen
mesh_terms: D000367:Age Factors; D002908:Chronic Disease; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D009679:Nuclear Family; D012737:Sex Factors; D018781:Tension-Type Headache / Q000453:epidemiology / Q000235:genetics*