Gastric mucosal function following withdrawal of omeprazole in rats.
In the following study the function of gastric mucosa after withdrawal of 4-week suppression of acid secretion was examined. Rats were treated orally for 4 weeks with omeprazole (CAS 73590-58-6, 150 mg/kg/day). While elevated plasma gastrin levels during the treatment returned to normal 4 days after the last dosing, exogenously applied pentagastrin induced higher acid secretion compared with the vehicle-treated controls. Acetylsalicylic acid induced mucosal lesion 3.6-fold over the control as well. In contrast, the HCl-induced lesion was inhibited by 24.4%. These results indicate that not only the acid secretion but also the mucosal protection is enhanced after 4-week treatment with omeprazole in rats.
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Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
Nagasaki
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Yomota
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D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D001241:Aspirin / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006632:Histamine / Q000378:metabolism; D008297:Male; D009853:Omeprazole / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D018712:Analgesics, Non-Narcotic; D000897:Anti-Ulcer Agents; D005755:Gastrins; D006632:Histamine; D009853:Omeprazole; D001241:Aspirin