[Hormonal treatment of proximal tubal pathology with the GnRH analogue leuprorelin].
In proximal tubal occlusions (PTO) the microsurgical anastomosis or in case of extensive tubal damage the in vitro-fertilisation (IVF) are the treatment modalities of choice. Aim of our study was to evaluate the effectivity of GnRH-analogues in the treatment of PTO. In 23 patients with repeatedly proven proximal tubal occlusion the GnRH-analogon Leuprorelin was applied for a 3 month period. 20 out of 23 patients completed the entire study including a further tubal patency test. 10 patients showed open tubes on both sides and in 2 cases one oviduct was patent. In 8 patients no effect of the hormonal treatment was found. Following the therapy 4 pregnancies occurred, 2 were located ectopically. Regarding tubal patency we could demonstrate a significant effect of hormonal treatment in proximal tubal occlusions (PTO). However, in respect to the pregnancy rate the results were not satisfactory. Therefore, the hormonal treatment of PTO by GnRH-analogues is limited to certain cases and doesn't represent a standard therapy.
Korell
M
M
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Ludwig Maximilians Universität, Aussenstelle Klinikum Grosshadern.
Löhrs
B
B
Strowitzki
T
T
Lebeau
A
A
Hepp
H
H
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D003251:Constriction, Pathologic / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005184:Fallopian Tube Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005186:Fallopian Tube Patency Tests; D005187:Fallopian Tubes / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D016729:Leuprolide / Q000008:administration & dosage* / Q000009:adverse effects; D008866:Microsurgery; D011247:Pregnancy; D016896:Treatment Outcome
D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide
Hormonelle Behandlung der proximalen Tubenpathologie mit dem GnRH-Analogon Leuprorelin.