Thermoeffector thresholds and preferred ambient temperatures of the FOK rat.
The FOK is an inbred rat strain with a genotypic adaptation to hot environments. The present study compared the thermoeffector thresholds and preferred ambient temperatures (Tpref) of the FOK rat with those of other rat strains. Male FOK, WKAH, and Donryu rats were used. First, they were loosely restrained and placed individually in a metabolic chamber with an ambient temperature of 26.0 degrees C. Their hypothalamic temperature (T(hy)), tail skin temperature (Tsk), and heat production (M) were measured. After thermal equilibrium had been attained, the rats were gradually warmed and then cooled using an intravenous thermode. The threshold T(hy) values for tail skin vasodilation and cold-induced thermogenesis were defined as the points at which sharp increases in Tsk and M occurred, respectively. The two thresholds of the FOK rat were lower than those of the WKAH and Donryu rats. In a second set of experiments, the FOK and WKAH rats were placed individually in a thermocline. Their intra-abdominal temperatures (T(ab)) were measured by a biotelemetry system, and the rats' Tpref values were estimated with the thermal gradient. Mean T(ab) and Tpref over a 24-h period for the FOK rat were significantly lower than those of the WKAH rat. The results suggest that in the FOK rat the control ranges of autonomic and behavioral thermoregulation are lower than those of the other rat strains examined. This contributes to the maintenance of core temperature at low levels.
Shido
O
O
Department of Physiology, School of Medicine, Faculty of Medicine, Kanazawa University, Japan.
Sakurada
S
S
Sugimoto
N
N
Furuyama
F
F
Nagasaka
T
T
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001831:Body Temperature; D001833:Body Temperature Regulation; D006358:Hot Temperature; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D013623:Tail