title: A metabolic approach to simulating the dynamics of C-14, H-3 and S-35 in sheep tissues.
abstract: The results of a study in which groups of sheep were given single oral administrations of 14C, 3H and 35S and then slaughtered over a period of 1 year are reported. The experimental data were used to investigate the potential of metabolically based models for describing the transfer of the three radionuclides to sheep tissues. The structure of these models is based upon a simplified understanding of the transfer of the macro-elements C, H and S by processes such as respiration and protein synthesis/degradation. A consequence of this approach is that the three models have many common parameters. The models reproduced the general trends of the observations, accounting for 74%, 66%, and 58% of the observed variation in the 14C, 3H and 35S data, respectively, suggesting that they may provide a useful alternative approach to modelling the transfer of these radionuclides. The models presented are limited to the particular experimental situation for which they were developed, and further experimental work would be required to extend them. However, such metabolically based models have great potential: for example, they should be able to account for the influence of dietary intake, physiological status or the form of the radionuclide in the animals diet (e.g. tritiated water or organically bound tritium).
authors.affiliation: Department of Physiology and Environmental Science, University of Nottingham, Sutton Bonington, UK.
authors.forename: N M
authors.initials: NM
authors.lastname: Crout
authors.forename: R W
authors.initials: RW
authors.lastname: Mayes
authors.forename: N A
authors.initials: NA
authors.lastname: Beresford
authors.forename: C S
authors.initials: CS
authors.lastname: Lamb
authors.forename: B J
authors.initials: BJ
authors.lastname: Howard
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*; D013462:Sulfur Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution; D014316:Tritium / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D002250:Carbon Radioisotopes; D013462:Sulfur Radioisotopes; D014316:Tritium