Cytotoxic substances produced by a fungal strain from a sponge: physico-chemical properties and structures.
Five novel metabolites, trichodenones A-C (1-3), harzialactone A (4) and B (5), have been isolated together with known R-mevalonolactone (6) from the culture broth of a strain of Trichoderma harzianum OUPS-N115 originally separated from the sponge Halichondria okadai. Their structures have been elucidated by spectral evidence. Among them, 1-3 exhibited significant cytotoxicity against cultured P388 cells.
Amagata
T
T
Osaka University of Pharmaceutical Sciences, Japan.
Usami
Y
Y
Minoura
K
K
Ito
T
T
Numata
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D003517:Cyclopentanes / Q000737:chemistry* / Q000302:isolation & purification*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011161:Porifera / Q000382:microbiology*; D014242:Trichoderma / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism
D000970:Antineoplastic Agents; D003517:Cyclopentanes; D007783:Lactones; C111277:harzialactone-A; C111278:harzialactone-B; C111274:trichodenone-A; C111275:trichodenone-B; C111276:trichodenone-C