title: Trisomy 3 as the sole karyotypic change in a pediatric immature teratoma.
abstract: Cytogenetic analysis of short-term cultured cells from an immature ovarian teratoma of a 9-year-old girl disclosed an extra copy of chromosome 3 as the sole clonal abnormality. The fact that trisomy 3 was previously reported as the only karyotypic change in two ovarian germ-cell tumors--one teratoma NOS and one immature teratoma--suggests that gain of chromosome 3 constitutes an early and pathogenetically important change in a subset of female germ-cell tumors.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Mertens
authors.forename: C M
authors.initials: CM
authors.lastname: Kullendorff
authors.forename: L
authors.initials: L
authors.lastname: Hjorth
authors.forename: J
authors.initials: J
authors.lastname: Alumets
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D013724:Teratoma / Q000235:genetics*; D014314:Trisomy