Wave propagation mediated by GABAB synapse and rebound excitation in an inhibitory network: a reduced model approach.
A reduction method is used to analyze a spatially structured network model of inhibitory neurons. This network model displays wave propagation of postinhibitory rebound activity, which depends on GABAB synaptic interactions among the neurons. The reduced model allows explicit solutions for the wavefronts and their velocity as a function of various parameters, such as the synaptic coupling strength. These predictions are shown to agree well with the numerical simulations of the conductance-based biophysical model.
Chen
Z
Z
Department of Mathematics, University of Pittsburgh, PA 15260, USA.
Ermentrout
B
B
Wang
X J
XJ
D004553:Electric Conductivity; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology*; D018080:Receptors, GABA-B / Q000502:physiology*; D012890:Sleep / Q000502:physiology; D013569:Synapses / Q000737:chemistry* / Q000502:physiology*; D013788:Thalamus / Q000737:chemistry / Q000502:physiology
D018080:Receptors, GABA-B