title: Amide derivatives with H1-antihistaminic effect.
abstract: The synthesis and the structure-activity correlation of a series of N-aminoalkylacetamides as H1-antihistaminic agents have been carried out. The compounds were tested in vitro by measurement of the inhibition of histamine-induced contractions on isolated guinea pig ileum; the results are expressed as pA2.
authors.affiliation: Facoltà di Farmacia, Università degli Studi di Salerno, Penta-Salerno, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Saturnino
authors.forename: P
authors.initials: P
authors.lastname: Saturnino
authors.forename: G
authors.initials: G
authors.lastname: De Martino
authors.forename: J C
authors.initials: JC
authors.lastname: Lancelot
authors.forename: D
authors.initials: D
authors.lastname: Perrine
authors.forename: R
authors.initials: R
authors.lastname: Boureau
authors.forename: M
authors.initials: M
authors.lastname: Robba
mesh_terms: D000577:Amides / Q000737:chemistry*; D000818:Animals; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D006634:Histamine H1 Antagonists; D006632:Histamine