title: Antimicrobial resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995.
abstract: Three hundred and thirty-three Shigella isolates obtained in 1986 to 1995 were tested for their susceptibilities to 19 antimicrobial agents. Nalidixic acid resistance had emerged in 59.6% of Shigella flexneri isolates during 1994 to 1995, with all tested resistant isolates having the mutation in gyrA encoding the Ser-83 alteration. Multiresistance (resistance to four or more agents) was more common in S. flexneri than in Shigella sonnei.
authors.affiliation: Department of Microbiology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories.
authors.forename: Y W
authors.initials: YW
authors.lastname: Chu
authors.forename: E T
authors.initials: ET
authors.lastname: Houang
authors.forename: D J
authors.initials: DJ
authors.lastname: Lyon
authors.forename: J M
authors.initials: JM
authors.lastname: Ling
authors.forename: T K
authors.initials: TK
authors.lastname: Ng
authors.forename: A F
authors.initials: AF
authors.lastname: Cheng
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics; D006723:Hong Kong; D006801:Humans; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology*; D012763:Shigella flexneri / Q000187:drug effects* / Q000235:genetics; D012764:Shigella sonnei / Q000187:drug effects* / Q000235:genetics
chemical_list: D000890:Anti-Infective Agents; D009268:Nalidixic Acid; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II