Efficacy of doxycycline and ciprofloxacin against experimental Yersinia pestis infection.
The efficacies of ciprofloxacin and doxycycline prophylaxis and therapy were assessed against experimental pneumonic plague infections induced by two strains of Yersinia pestis in a mouse model. When exposed to an aerosol of Y. pestis strain GB, containing 8.39 x 10(5) +/- 4.17 x 10(4) cfu, the retained dose was 7.3 x 10(3) +/- 2.3 x 10(3) cfu. When exposed to an aerosol of Y. pestis strain CO-92, containing 1.86 x 10(5) +/- 7.4 x 10(3) cfu, the retained dose was 3.4 x 10(4) +/- 2.6 x 10(3) cfu. Both strains resulted in a respiratory and systemic infection closely resembling human pneumonic plague. Ciprofloxacin prophylaxis and therapy was successful against both strains for up to 24 h after challenge, but not after 48 h. Both doxycycline prophylaxis and therapy regimens were ineffective against both strains, although strain CO-92 was more susceptible in vitro to doxycycline than strain GB and supra-MIC levels were achieved in the serum and lungs of the animal.
Russell
P
P
CBD Porton Down, Salisbury, Wiltshire, UK.
Eley
S M
SM
Green
M
M
Stagg
A J
AJ
Taylor
R R
RR
Nelson
M
M
Beedham
R J
RJ
Bell
D L
DL
Rogers
D
D
Whittington
D
D
Titball
R W
RW
D000818:Animals; D019072:Antibiotic Prophylaxis; D002939:Ciprofloxacin / Q000494:pharmacology*; D004195:Disease Models, Animal; D004318:Doxycycline / Q000494:pharmacology*; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008826:Microbial Sensitivity Tests; D010930:Plague / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D016896:Treatment Outcome; D015010:Yersinia pestis / Q000187:drug effects*
D002939:Ciprofloxacin; D004318:Doxycycline