title: Quantitative structure-activity relationship study of some 7-substituted theophyllines.
abstract: Some novel 7-substituted theophylline derivatives have been investigated for quantitative structure-activity relationship (QSAR). For this purpose, their bronchodilatory activities (in vitro), which were examined by the inhibition of acetylcholine induced contraction in tracheae isolated from guinea pigs, have been correlated with various quantum chemical and physicochemical parameters.
authors.affiliation: Middle East Technical University, Department of Chemistry, Ankara, Turkey.
authors.forename: L
authors.initials: L
authors.lastname: Türker
authors.forename: H
authors.initials: H
authors.lastname: Akgün
authors.forename: A
authors.initials: A
authors.lastname: Balkan
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001993:Bronchodilator Agents / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001993:Bronchodilator Agents; D013806:Theophylline; D000109:Acetylcholine