GABAergic function in detoxified heroin addicts: relationship to anxiety disorders.
The function of the GABAergic system was examined in 20 subjects with heroin dependence and abuse, 2 months after detoxification, and in 10 healthy volunteers, by measuring the growth hormone (GH) response to a challenge with the GABA B receptor agonist baclofen. Ten heroin addicts had comorbid anxiety disorder (Group A), while the other ten had heroin addiction uncomplicated by Axis I and II psychopathologies (Group B). GH responses to baclofen stimulation of Group A patients were significantly blunted, while those of Group B subjects did not differ from responses of healthy volunteers. Our data show that the function of the GABAergic system is impaired only in heroin addicts with comorbid anxiety disorders (anxious cluster), suggesting that the GABA system is not persistently influenced by prolonged exposure to opioid receptor stimulation.
Gerra
G
G
Centro Studi Farmacotossicodipendenze, Ser.T., Azienda USL, Parma, Italy.
Ferri
M
M
Zaimovic
A
A
Giucastro
G
G
Palladino
M
M
Sartori
R
R
Delsignore
R
R
Maestri
D
D
Marzocchi
G
G
Brambilla
F
F
D000328:Adult; D000704:Analysis of Variance; D001008:Anxiety Disorders / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D001418:Baclofen / Q000494:pharmacology; D018755:GABA Agonists / Q000494:pharmacology; D003932:Heroin / Q000493:pharmacokinetics*; D006556:Heroin Dependence / Q000150:complications / Q000534:rehabilitation*; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D011569:Psychiatric Status Rating Scales; D018079:Receptors, GABA / Q000187:drug effects / Q000378:metabolism*
D018755:GABA Agonists; D018079:Receptors, GABA; D003932:Heroin; D001418:Baclofen