title: Drug eruption (erythema multiforme type) due to a digestive enzyme drug.
abstract: An 84-year-old Japanese male had pruritic indurated erythema on his upper limb and left lower abdomen, which had developed abruptly two months before visiting our hospital. Hematological examination showed eosinophilia, 550/mm3. Histopathological findings were suggestive of erythema multiforme in response to a drug. By means of patch tests and a p.o. challenge test, Aczym, a digestive enzyme drug, was shown to be the cause of his condition. Further study revealed that the specific ingredients involved were pancreatin and Taka-diastase. An eruption resulting from ingestion of a digestive enzyme drug has not previously been reported.
authors.affiliation: Department of Dermatology, Kagoshima University Faculty of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Miyoshi
authors.forename: T
authors.initials: T
authors.lastname: Kanzaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003875:Drug Eruptions / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced; D004892:Erythema Multiforme / Q000139:chemically induced*; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010194:Pancreatin / Q000009:adverse effects*; D010328:Patch Tests; D011537:Pruritus / Q000139:chemically induced; D000516:alpha-Amylases / Q000009:adverse effects*
chemical_list: D005765:Gastrointestinal Agents; D010194:Pancreatin; D000516:alpha-Amylases