[NO synthetase in the cells of different tissues and organs of the mouse].
Cellular NO synthase was assayed in bone marrow, spleen, thymus, lymph nodes, epidermis, hypodermic connective tissue, small gut, peritoneal exudate, liver, kidney, and heart by cytochemical and immunofluorescent methods. As a rule the enzymatic activity was found in differentiated cells that finished proliferation (mature hemopoietic cells, epithelium of gut villi, etc.). The enzyme activity was undetectable in actively reproducing low-differentiated cells (basal layer of the epidermis, crypt cells of the small gut, or blast hemopoietic forms). NO is proposed to participate in regulation of tissue-specific terminal differentiation (maturation) of the cells.
Vasil'eva
T V
TV
Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
Michurina
T V
TV
Radionova
Iu V
IuV
Kuzin
B A
BA
Enikolopov
G N
GN
Khrushchov
N G
NG
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019084:Fluorescent Antibody Technique, Indirect; D006651:Histocytochemistry; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D019001:Nitric Oxide Synthase / Q000378:metabolism*
D007527:Isoenzymes; D019001:Nitric Oxide Synthase
Issledovanie NO-sintetazy v kletkakh razlichnykh tkaneĭ i organov myshi.