title: [Fatal poisoning with clozapine and perazine. A case report].
abstract: An intoxication following an apparent overdose of clozapine (Leponex) and perazine (Taxilan) is reported. There was a wide range of variation in postmortem blood and tissue concentrations of clozapine, desmethyclozapine and perazine. Clozapine/norclozapine blood and tissue ratios and perazine-pill-fragments in the gastric content could be used as a sign of suspected acute clozapine and perazine overdose.
authors.affiliation: Institut für Rechtsmedizin und Verkehrsmedizin, Universität Heidelberg.
authors.forename: B
authors.initials: B
authors.lastname: Ganssmann
authors.forename: G
authors.initials: G
authors.lastname: Skopp
authors.forename: R
authors.initials: R
authors.lastname: Aderjan
authors.forename: R
authors.initials: R
authors.lastname: Mattern
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000506:poisoning* / Q000627:therapeutic use; D002423:Cause of Death; D003024:Clozapine / Q000506:poisoning* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010464:Perazine / Q000506:poisoning* / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy / Q000401:mortality; D013405:Suicide / Q000331:legislation & jurisprudence*; D013406:Suicide, Attempted / Q000331:legislation & jurisprudence
chemical_list: D014150:Antipsychotic Agents; D010464:Perazine; D003024:Clozapine
vernacular_title: Tödliche Vergiftung mit Clozapin und Perazin. Eine Falldarstellung.