title: Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.
authors.affiliation: Department of Chemistry, Searle, Monsanto, Skokie, Illinois 60077, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Hallinan
authors.forename: S
authors.initials: S
authors.lastname: Tsymbalov
authors.forename: P M
authors.initials: PM
authors.lastname: Finnegan
authors.forename: W M
authors.initials: WM
authors.lastname: Moore
authors.forename: G M
authors.initials: GM
authors.lastname: Jerome
authors.forename: M G
authors.initials: MG
authors.lastname: Currie
authors.forename: B S
authors.initials: BS
authors.lastname: Pitzele
mesh_terms: D004790:Enzyme Induction / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005233:Fatty Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D005233:Fatty Alcohols; D007097:Imines; C111347:N-(5-amino-6,7-dihydroxyheptyl)ethanimidamide; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II