title: Effects of electroconvulsive therapy in adolescents with severe endogenous depression resistant to pharmacotherapy.
abstract: BACKGROUND
  This open, prospective study examined the effects of electroconvulsive therapy (ECT) in 10 adolescents with primary, endogenous, psychotic depression who were resistant to antidepressant pharmacotherapy.
  
  
  METHODS
  Change in symptom severity from baseline was assessed weekly with Hamilton Depression Rating Scale (HDRS) ratings, and outcome was measured additionally at 1 month, and again at 1 year, post-ECT.
  
  
  RESULTS
  All but 1 patient demonstrated dramatic improvement, with statistically significant decreases in mean HDRS score detected after the first week of treatment. All responders maintained the benefits of their treatment.
  
  
  CONCLUSIONS
  The results provide evidence of the clinical effectiveness of ECT in adolescents with phenomenological characteristics shown to be predictive of ECT response in adults.
authors.affiliation: Department of Psychiatry & Biobehavioral Sciences, Neuropsychiatric Institute & Hospital, School of Medicine, University of California at Los Angeles 90024-1759, USA.
authors.forename: M
authors.initials: M
authors.lastname: Strober
authors.forename: U
authors.initials: U
authors.lastname: Rao
authors.forename: M
authors.initials: M
authors.lastname: DeAntonio
authors.forename: E
authors.initials: E
authors.lastname: Liston
authors.forename: M
authors.initials: M
authors.lastname: State
authors.forename: L
authors.initials: L
authors.lastname: Amaya-Jackson
authors.forename: S
authors.initials: S
authors.lastname: Latz
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D004351:Drug Resistance; D004565:Electroconvulsive Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents