title: Unusual nasal and orbital involvement of glioblastoma multiforme: a case report and review of the literature.
abstract: We describe a case of glioblastoma treated with chemoradiotherapy that spread to the dura mater with direct invasion of the skull base, protrusion into the homolateral nasal fossa, and penetrated of the frontal sinus, the orbital wall and the ethmoidal sinuses. Only eight cases of glioblastoma showing this development have been described in the literature; one of these, however, had a sarcomatous component which was absent in our case.
authors.affiliation: Department of Medical Oncology, Azienda Ospedaliera, Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Brandes
authors.forename: C
authors.initials: C
authors.lastname: Carollo
authors.forename: M
authors.initials: M
authors.lastname: Gardiman
authors.forename: E
authors.initials: E
authors.lastname: Scelzi
authors.forename: R
authors.initials: R
authors.lastname: Bottin
authors.forename: P
authors.initials: P
authors.lastname: Zampieri
authors.forename: A
authors.initials: A
authors.lastname: Rigon
authors.forename: M V
authors.initials: MV
authors.lastname: Fiorentino
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology*; D004388:Dura Mater / Q000473:pathology; D005909:Glioblastoma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000556:secondary*; D009361:Neoplasm Invasiveness; D009918:Orbital Neoplasms / Q000473:pathology* / Q000556:secondary*; D019292:Skull Base Neoplasms / Q000473:pathology / Q000556:secondary