Fatal overdose of olanzepine.
An ingestion of an unknown quantity of Zyprexa (olanzapine) tablets in a suicide is described. Biological fluid samples obtained at autopsy were analyzed for the presence of olanzapine by gas chromatography equipped with nitrogen-phosphorous detector and gas chromatography/mass spectroscopy. The blood concentration of olanzapine was 490 micrograms/dl and the concentration in gastric contents was 4100 micrograms/dl.
Elian
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Commonwealth of Massachusetts, Forensic Toxicology Laboratory, Sudbury, MA 01776, USA.
D014150:Antipsychotic Agents / Q000097:blood / Q000506:poisoning*; D001569:Benzodiazepines; D001774:Blood Chemical Analysis; D062787:Drug Overdose; D017809:Fatal Outcome; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005750:Gastric Juice / Q000737:chemistry; D006801:Humans; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000097:blood / Q000506:poisoning; D013405:Suicide
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine