Pathophysiological response of cytokines and vasoactive agents in patients undergoing total gastrectomy.
OBJECTIVE
To investigate the involvement of vasoactive agents, endothelin (ET)-1, and atrial natriuretic peptide (ANP), and the responses of cytokines in patients undergoing total gastrectomy.


METHODS
Prospective study.


METHODS
University hospital, Japan.


METHODS
20 patients with advanced gastric cancer who had undergone total gastrectomy with lymph node dissection.


METHODS
Serum or plasma samples collected on the day before the operation, at the time of skin closure, and on postoperative days 1, 3, 5, and 7.


METHODS
Concentrations of acute phase reactants, cytokines (interleukin (IL)-1, tumour necrosis factor (TNF) and interleukin (IL)-6), and vasoactive agents (ET-1 and ANP).


RESULTS
There were significant increases in concentrations of IL-6 and acute phase reactants postoperatively. ET-1 and ANP concentrations did not change significantly.


CONCLUSIONS
There was no correlation between concentrations of the vasoactive agents ET-1 and ANP, and those of acute phase reactants or cytokines in serum or plasma in patients undergoing total gastrectomy.
Shito
M
M
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Ueda
M
M
Wakabayashi
G
G
Endo
M
M
Kitajima
M
M
D000209:Acute-Phase Proteins / Q000032:analysis; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D019272:Leukocyte Elastase / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000209:Acute-Phase Proteins; D016207:Cytokines; D019332:Endothelin-1; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D009320:Atrial Natriuretic Factor; D002097:C-Reactive Protein; D019272:Leukocyte Elastase