title: African origin of GB virus C/hepatitis G virus.
abstract: Ninety-four GB virus C/hepatitis G virus (GBV-C/ HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBV-C/HGV.
authors.affiliation: Second Department of Medicine, Nagoya City University Medical School, Kawasumi, Mizuho, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Mizokami
authors.forename: E
authors.initials: E
authors.lastname: Orito
authors.forename: K
authors.initials: K
authors.lastname: Ohba
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Kondo
authors.forename: I
authors.initials: I
authors.lastname: Mboudjeka
authors.forename: L
authors.initials: L
authors.lastname: Zekeng
authors.forename: L
authors.initials: L
authors.lastname: Kaptue
authors.forename: B
authors.initials: B
authors.lastname: Bikandou
authors.forename: P
authors.initials: P
authors.lastname: M'Pele
authors.forename: J
authors.initials: J
authors.lastname: Takehisa
authors.forename: M
authors.initials: M
authors.lastname: Hayami
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Gojobori
mesh_terms: D000349:Africa; D000595:Amino Acid Sequence; D018067:Flaviviridae / Q000737:chemistry* / Q000235:genetics; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D020365:RNA Helicases; D012367:RNA, Viral / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012697:Serine Endopeptidases; D017361:Viral Nonstructural Proteins / Q000235:genetics*; D014764:Viral Proteins / Q000737:chemistry*; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D020365:RNA Helicases; D012367:RNA, Viral; D012697:Serine Endopeptidases; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C060028:NS3 protein, flavivirus; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C096041:NS5 protein, flavivirus