title: Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.
abstract: We characterized the effects of Leishmania infection on activation-induced translocation of protein kinase C (PKC) isoforms in murine bone marrow-derived macrophages. Although PKC-dependent gene expression was attenuated by infection, the distribution and translocation of PKC isoforms were unaffected. However, subsequent dissociation from membranes was substantially delayed for some isoforms, particularly PKCbeta.
authors.affiliation: Department of Medicine, University of California San Francisco, 94143-0654, USA.
authors.forename: S
authors.initials: S
authors.lastname: Pingel
authors.forename: Z E
authors.initials: ZE
authors.lastname: Wang
authors.forename: R M
authors.initials: RM
authors.lastname: Locksley
mesh_terms: D000818:Animals; D007527:Isoenzymes / Q000032:analysis*; D018320:Leishmania major / Q000502:physiology*; D008264:Macrophages / Q000201:enzymology* / Q000469:parasitology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011493:Protein Kinase C / Q000032:analysis*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D007527:Isoenzymes; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate