Excretion of a fluorescent rapamycin-derivative in proximal kidney tubules is mediated by P-glycoprotein.
Fricker
G
G
Institut für Pharmazeutische Technologie und Biopharmazie, Heidelberg, Germany.
Drewe
J
J
Miller
D S
DS
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D004058:Diffusion; D018432:Drug Resistance, Multiple; D005456:Fluorescent Dyes; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D007695:Killifishes; D018613:Microscopy, Confocal; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D011090:Polyenes / Q000032:analysis / Q000493:pharmacokinetics*; D020123:Sirolimus
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D005456:Fluorescent Dyes; D007166:Immunosuppressive Agents; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D011090:Polyenes; D020123:Sirolimus