title: Disseminated reticulate hypomelanosis developing during primary biliary cirrhosis.
abstract: We report on a 50-year-old woman with disseminated reticulate hypomelanosis developing on the limbs and abdomen during primary biliary cirrhosis (PBC). Histopathological examination showed vacuolar basal cells, dyskeratosis and large multinucleated epidermal cells. Diagnosis of lichen sclerosus et atrophicus and autoimmune disease are discussed. The similarity between cutaneous changes in PBC and a graft-versus-host reaction is outlined.
authors.affiliation: Department of Dermatology, Purpan La Grave Hospital, Toulouse, France.
authors.forename: R
authors.initials: R
authors.lastname: Viraben
authors.forename: B
authors.initials: B
authors.lastname: Couret
authors.forename: B
authors.initials: B
authors.lastname: Gorguet
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis; D002467:Cell Nucleus / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004817:Epidermis / Q000473:pathology; D005260:Female; D006087:Graft vs Host Reaction / Q000276:immunology; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology* / Q000473:pathology; D015603:Keratinocytes / Q000473:pathology; D007642:Keratosis / Q000473:pathology; D018459:Lichen Sclerosus et Atrophicus / Q000175:diagnosis; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D014617:Vacuoles / Q000648:ultrastructure