title: [Therapy with large doses of methylprednisolone in Basedow's ophthalmopathy].
abstract: Up to now there is no satisfactory therapeutical method in Graves' ophthalmopathy (GO). Recently, several authors have published the results of the so-called "pulse" method of corticotherapy, using intravenous methylprednisolone (MP) 1 g dissolved in 200 ml isotonic NaCl solution. We have treated with this method 4 patients (3 women and 1 man, aged between 35-62 years) with severe GO (III-V class after AMT Classification). Although the number of perfusions varied between 1 (2 patients) and 8, the results are encouraging: 3 improvements, 1 stationary evolution (after a single "pulse"). We have not noticed important side-effects. In conclusion we consider that the "pulse" method have proved its efficiency, recommendable in severe GO.
authors.affiliation: Clinica Endocrinologică, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: E
authors.initials: E
authors.lastname: Zbranca
authors.forename: V
authors.initials: V
authors.lastname: Mogoş
authors.forename: G
authors.initials: G
authors.lastname: Nisfoeanu
authors.forename: C
authors.initials: C
authors.lastname: Vulpoi
authors.forename: V
authors.initials: V
authors.lastname: Gneazdovschi
authors.forename: D
authors.initials: D
authors.lastname: Georgescu
mesh_terms: D000328:Adult; D004341:Drug Evaluation; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone
vernacular_title: Terapia cu doze mari de metilprednisolon în oftalmopatia basedowiană.