[The developmental characteristics of the embryonic anlagen of rat neocortex and spinal cord when transplanted into the distal end of the dissected sciatic nerve of adult animals].
The spinal cord and cerebral cortex of 14 day old embryos of Wistar rats were transplanted into the distal stump of the adult rat cut sciatic nerve in order to study dynamics of the development of the transplanted cell elements, and to elucidate relations of neuronal elements in the central and peripheral nervous systems. By means of light and electron microscopy it has been stated that the transplanted nerve cells of the cortex and spinal cord could survive for 60 days and differentiate from neuroepithelial cells and neuroblasts up to young and mature neurons. In the transplants a neuropil is seen to form with both unmyelinated and myelinated axons and synaptic contacts. In the cortex transplants cavities appear paved with ependyma-like cells having cilia and microvilli. It has been found that axons of the transplanted spinal cord neurons may leave transplants to be myelinated by the recipient's Schwann cells of the peripheral nerve.
Petrova
E S
ES
Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Chumasov
E I
EI
Otellin
V A
VA
D000818:Animals; D016380:Brain Tissue Transplantation; D005260:Female; D016332:Fetal Tissue Transplantation; D008854:Microscopy, Electron; D019579:Neocortex / Q000196:embryology / Q000637:transplantation* / Q000648:ultrastructure; D009474:Neurons / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve; D016622:Silver Staining; D013116:Spinal Cord / Q000196:embryology / Q000637:transplantation* / Q000648:ultrastructure; D013997:Time Factors; D016042:Transplantation, Heterotopic
Osobennosti razvitiia émbrional'nykh zakladok neokorteksa i spinnogo mozga krys v usloviiakh transplantatsii v distal'nyĭ konets pererezannogo sedalishchnogo nerva vzroslykh zhivotnykh.