Immunohistochemical demonstration of beta-endorphin in guinea pig sebaceous glands of normal skin and during immune inflammation.
Very suggestive evidence for possible role of beta-endorphin (BE) in immune activity has been continuously accumulated in the literature in spite of contradictory results about the involvement of the opiate system in immunological response. The reversed passive Arthus reaction (RPAR) was performed in the dorsal area of the guinea pig skin and immunohistochemical PAP method was applied for visualisation of BE. The positive BE immunoreactivity was observed in sebaceous gland cells (SGC) , mainly localized in the middle layer of the glands, both in the normal and experimental skin. The maximal intensity of immunoreactivity to BE in SGC during RPAR was stronger than normal. In control skin, 50% of SGC revealed positive immunoreactivity comparing to 60-66% in the late phase of RPAR. Sebaceous glands (SGs) probably take part in local homeostasis in the skin, also during immune inflammation.
Gendek-Kubiak
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Department of Histology and Embryology, Medical University, Lódź, Poland.
D000818:Animals; D001183:Arthus Reaction / Q000276:immunology; D006168:Guinea Pigs; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology*; D008297:Male; D012627:Sebaceous Glands / Q000166:cytology* / Q000276:immunology; D012867:Skin / Q000166:cytology* / Q000276:immunology; D001615:beta-Endorphin / Q000378:metabolism*
D001615:beta-Endorphin