In vivo preclinical test models for studying airway mucus secretion.
There are many in vivo animal models for studying airway mucus secretion and hypersecretion, each with advantages and disadvantages. Use of a particular test system will depend upon the aspect of secretion to be modelled. Airway hypersecretory diseases exhibit chronic mucus hypersecretion, of which the clinical impact is predominantly in the distal airways. The majority of documented test preparations study acute secretion, invariably using tracheal preparations, but have been invaluable in elucidating the normal physiology of airway mucus secretion. Chronic models of the hypersecretory state in the distal airways have been developed, but are predominantly histologic in nature (for example quantification of increased goblet cell number). There are few investigations of mucus hypersecretion. Examination of the 'antisecretory' potential of pharmaceutical compounds has been investigated predominantly in chronic histologic models with the drug being given 'prophylactically' rather than 'therapeutically'. Refinement of chronic hypersecretory models should lead to elucidation of the connection between airway irritation, inflammation, MUC gene expression, mucous cell hyperplasia/metaplasia, airway hypersecretion and bronchial hypersecretory disease.
Rogers
D F
DF
Thoracic Medicine, National Heart & Lung Institute (Imperial College), Dovehouse Street, London, SW3 6LY, U.K. duncan.rogers@ic.ac.uk
D000818:Animals; D001980:Bronchi / Q000378:metabolism / Q000503:physiopathology*; D008954:Models, Biological; D009093:Mucus / Q000378:metabolism*; D012907:Smoking / Q000009:adverse effects; D014132:Trachea / Q000378:metabolism / Q000503:physiopathology*