Effect of chronic amitriptyline administration on serotonergic receptors in rats with methylazoxymethanol-induced microencephaly.
Methylazoxymethanol (MAM)-induced cortical hypoplasia resulted in a 20% decrease in the Bmax of 5-HT2A receptors in the frontal cortex with no change in the Bmax of 5-HT1A receptors. Chronic treatment with amitriptyline did not further decrease the Bmax of 5-HT2A receptors in the MAM-lesioned cortex, suggesting that the persistent down-regulation of cortical 5-HT2A receptors in MAM-lesioned rats was induced by serotonergic hyperinnervation.
Watanabe
M
M
Department of Psychopharmacology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, Setagaya-ku, Tokyo 156, Japan. watanabe@prit.go.jp
Kodama
Y
Y
Hagino
Y
Y
Nonaka
R
R
Kaichi
Y
Y
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000477:Alkylating Agents; D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D005260:Female; D007650:Ketanserin / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives*; D008831:Microcephaly / Q000139:chemically induced / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D000477:Alkylating Agents; D000929:Antidepressive Agents, Tricyclic; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D000639:Amitriptyline; D008746:Methylazoxymethanol Acetate; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007650:Ketanserin; C030667:methylazoxymethanol