title: [Efficacy of moxonidine, an imidazoline receptor agonist, in patients with essential hypertension].
abstract: OBJECTIVE
  Study of zint (moxonidine), a hypotensive drug with the central mechanism of action.
  
  
  METHODS
  The hemodynamics and platelet functional activity were assessed in 30 patients with essential hypertension treated by zint in a daily dose of 0.4 mg, taken in the morning, for 3 months.
  
  
  RESULTS
  By the end of treatment the systolic arterial pressure decreased by 23 +/- 4 mm Hg, diastolic by 15 +/- mm Hg, mean pressure by 17 +/- 2 mm Hg, and heart rate by 5 +/- 4 str/min. Echography showed that myocardial hypertrophy decreased but negligibly. An evident decrease of ADP-induced platelet aggregation was observed.
  
  
  CONCLUSIONS
  Zint therapy may be a most physiological method of arterial hypertension control.
authors.forename: E V
authors.initials: EV
authors.lastname: Baliakina
authors.forename: I F
authors.initials: IF
authors.lastname: Patrusheva
authors.forename: E E
authors.initials: EE
authors.lastname: Rynskova
authors.forename: A P
authors.initials: AP
authors.lastname: Iurenev
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004452:Echocardiography; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000188:drug therapy; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D054755:Imidazoline Receptors; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D011955:Receptors, Drug / Q000819:agonists*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D007093:Imidazoles; D054755:Imidazoline Receptors; D010975:Platelet Aggregation Inhibitors; D011955:Receptors, Drug; C043482:moxonidine
vernacular_title: Opyt primeneniia agonista imidazolinovykh retseptorov moksonidina u bol'nykh gipertonicheskoĭ bolezn'iu (sobstvennoe nabliudenie).