Effects of probenecid and cimetidine on renal disposition of ofloxacin in rats.
The renal handling of ofloxacin in rats which were given ofloxacin either alone or in combination with probenecid or cimetidine was studied. In the presence of cimetidine or probenecid, ofloxacin's total and renal clearances were reduced and its half-life was prolonged. This suggests that ofloxacin is secreted by both the anionic and cationic transport systems.
Foote
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Department of Medicine, Hennepin County Medical Center, and College of Pharmacy, University of Minnesota, Minneapolis 55455, USA. efoote@rci.rutgers.edu
Halstenson
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CE
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000652:urine; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008657:Metabolic Clearance Rate; D015242:Ofloxacin / Q000493:pharmacokinetics* / Q000652:urine; D011339:Probenecid / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012076:Renal Agents / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000897:Anti-Ulcer Agents; D012076:Renal Agents; D002927:Cimetidine; D015242:Ofloxacin; D011339:Probenecid