[The cytokine-inducing activity of the Yersinia pestis "murine" toxin].
In this work the data obtained in the study of cytokinin-inducing activity of Y. pestis "mouse" toxin (MT) are presented. The study revealed that MT induced the synthesis of IL 1, IL 2 and TNF alpha. The most pronounced activity in MT was IL 2 inducing activity having dose-dependent character: the effect increased with the decrease of the dose of the preparation. The maximum level of the synthesis of IL 2 was observed when very low doses of the preparation (0.01 microgram/ml) were used, which was characteristic of superantigens. The presented data suggest that IL 2 plays an essential role in the mechanism of immunopathological reactions stipulated by MT.
Vasil'eva
G I
GI
Research Institute for Plague Control, Rostov-on-Don.
Mishan'kin
M B
MB
Kozlovskiĭ
V N
VN
Verkina
L M
LM
Mishan'kin
B N
BN
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001427:Bacterial Toxins / Q000276:immunology*; D002478:Cells, Cultured; D004269:DNA, Bacterial; D004274:DNA, Recombinant; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000235:genetics / Q000276:immunology; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D051379:Mice; D010957:Plasmids; D018089:Superantigens / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000187:drug effects*; D015010:Yersinia pestis / Q000276:immunology*
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D004269:DNA, Bacterial; D004274:DNA, Recombinant; D007375:Interleukin-1; D007376:Interleukin-2; D018089:Superantigens; D014409:Tumor Necrosis Factor-alpha
Tsitokinindutsiruiushchaia aktivnost' "myshinogo" toksina Yersinia pestis.