title: Expression of Kin, a nuclear protein binding to curved DNA, in mammal and avian brains.
abstract: Kin is a nuclear protein which presents cross-immunoreactivity with the bacterial RecA protein and which efficiently binds to curved DNA. This genomic interaction could be implied in DNA repair and illegitimate recombination in eukaryotic cells. Using immunocytochemistry with anti-RecA antibodies, we report the ubiquitous presence of the Kin protein in the CNS of mice and quails. However, some brain structures such as the hippocampal area, the locus coeruleus and Purkinje cells are preferentially immunolabelled and show some homologies between the two species. In conclusion, the expression of the Kin protein is preserved in the phylogeny of the brain of higher vertebrates.
authors.affiliation: Département de Médecine Expérimentale, Faculté de Médecine, Université Claude Bernard, INSERM U52, CNRS ERS 5645, Lyon, France. mermet@sommeil.univ-lyon1.fr
authors.forename: N
authors.initials: N
authors.lastname: Mermet
authors.forename: J
authors.initials: J
authors.lastname: Angulo
authors.forename: J
authors.initials: J
authors.lastname: Repérant
authors.forename: M
authors.initials: M
authors.lastname: Medina
authors.forename: S
authors.initials: S
authors.lastname: Araneda
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D001933:Brain Stem / Q000737:chemistry; D003429:Cross Reactions; D004260:DNA Repair / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000032:analysis* / Q000276:immunology; D004027:Diencephalon / Q000737:chemistry; D019143:Evolution, Molecular; D005260:Female; D008297:Male; D051379:Mice; D009687:Nuclear Proteins; D009830:Olfactory Bulb / Q000737:chemistry; D011784:Quail; D011938:Rec A Recombinases / Q000276:immunology; D011995:Recombination, Genetic / Q000502:physiology*; D013045:Species Specificity
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C071214:Kin protein, mouse; D011938:Rec A Recombinases