title: Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: comparison with positron emission tomography values.
abstract: The authors determined cerebral blood flow (CBF) with magnetic resonance imaging (MRI) of contrast agent bolus passage and compared the results with those obtained by O-15 labeled water (H215O) and positron emission tomography (PET). Six pigs were examined by MRI and PET under normo- and hypercapnic conditions. After dose normalization and introduction of an empirical constant phi Gd, absolute regional CBF was calculated from MRI. The spatial resolution and the signal-to-noise ratio of CBF measurements by MRI were better than by the H215O-PET protocol. Magnetic resonance imaging cerebral blood volume (CBV) estimates obtained using this normalization constant correlated well with values obtained by O-15 labeled carbonmonooxide (C15O) PET. However, PET CBV values were approximately 2.5 times larger than absolute MRI CBV values, supporting the hypothesized sensitivity of MRI to small vessels.
authors.affiliation: Department of Neuroradiology, Arhus University Hospital, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Ostergaard
authors.forename: D F
authors.initials: DF
authors.lastname: Smith
authors.forename: P
authors.initials: P
authors.lastname: Vestergaard-Poulsen
authors.forename: S B
authors.initials: SB
authors.lastname: Hansen
authors.forename: A D
authors.initials: AD
authors.lastname: Gee
authors.forename: A
authors.initials: A
authors.lastname: Gjedde
authors.forename: C
authors.initials: C
authors.lastname: Gyldensted
mesh_terms: D000818:Animals; D001810:Blood Volume; D002248:Carbon Monoxide / Q000493:pharmacokinetics; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D006935:Hypercapnia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010104:Oxygen Radioisotopes / Q000493:pharmacokinetics; D013552:Swine; D014055:Tomography, Emission-Computed
chemical_list: D003287:Contrast Media; D010104:Oxygen Radioisotopes; D002248:Carbon Monoxide