Chick Delta-1 gene expression and the formation of the feather primordia.
The chick dermis is known to control the formation of feathers and interfeathery skin in a hexagonal pattern. The evidence that the segregation of two types of fibroblasts involves Delta/Notch signalling is based on three facts. Rings of C-Delta-1-expressing fibroblasts precede and delimit the forming feather primordia. C-Delta-1 is uniformly expressed in the dermis of the scaleless mutant, which is almost entirely devoid of feathers. Feather development is inhibited by overexpression of C-Delta-1 in wild type dermis using a retroviral construct. We also show that the distribution of C-Delta-1 in the mutant dermis can be rescued by its association with a wild type epidermis, which acts as a permissive inducer, or by epidermal secreted proteins like FGF2.
Viallet
J P
JP
Equipe Biologie de la Différenciation Epithéliale, UMR CNRS 5538, Laboratoire d'Etude de la Différenciation et de l'Adhérence Cellulaires, Institut Albert Bonniot, Université Joseph Fourier, Grenoble, France.
Prin
F
F
Olivera-Martinez
I
I
Hirsinger
E
E
Pourquié
O
O
Dhouailly
D
D
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002450:Cell Communication; D002642:Chick Embryo; D004627:Embryonic Induction; D005241:Feathers / Q000196:embryology*; D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics*; D012867:Skin / Q000196:embryology
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C064045:delta protein; D016222:Fibroblast Growth Factor 2