In vitro activities of Y-688, a new 7-substituted fluoroquinolone, against anaerobic bacteria.
The in vitro activities of Y-688, a new 7-substituted fluoroquinolone derivative, against 317 nonduplicate anaerobic isolates were determined. Eighty-five percent of the Bacteroides fragilis group (n = 89) were inhibited by < or = 2 mg of Y-688 per liter, while 78, 100, 89, and 98% of gram-negative bacilli (n = 135), gram-positive cocci (n = 59), and non-spore-forming (n = 58) and spore-forming (n = 51) gram-positive bacilli, respectively, were inhibited by < or = 1 mg of Y-688 per liter.
MacGowan
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AP
Bristol Centre for Antimicrobial Research and Evaluation, University of Bristol, Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, United Kingdom. STAFF@BCARE.ORG.UK
Bowker
K E
KE
Wootton
M
M
Holt
H A
HA
Reeves
D S
DS
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C111081:Y 688