title: Acquired hepatocerebral degeneration: MR and pathologic findings.
abstract: Acquired (non-Wilsonian) hepatocerebral degeneration (AHD) is a rare irreversible neurologic syndrome that occurs in patients with chronic liver disease associated with multiple metabolic insults. The pathophysiology and the locations of the cerebral injuries are incompletely understood. We describe a patient with fatal hepatic cirrhosis and AHD in whom MR images showed abnormalities in the brachium pontis bilaterally. Neuropathologic evaluation disclosed multiple regions of subcortical spongiform white matter changes.
authors.affiliation: Department of Radiology, University of Pittsburgh School of Medicine, PA 15213, USA.
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: D
authors.initials: D
authors.lastname: Lacomis
authors.forename: S
authors.initials: S
authors.lastname: Comu
authors.forename: J
authors.initials: J
authors.lastname: Jacobsohn
authors.forename: E
authors.initials: E
authors.lastname: Kanal
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D009410:Nerve Degeneration / Q000175:diagnosis*