Release of peptide YY and inhibition of gastric acid secretion by long-chain and medium-chain triglycerides but not by sucrose polyester in men.
METHODS
In the present study, we have investigated the effects of intraduodenal perfusion of long-chain and medium-chain triglycerides and of sucrose polyester on the release of peptide YY in healthy men.


RESULTS
Perfusion of medium-chain triglycerides (180 mmol fatty acids) increased the plasma concentration of peptide YY from 7.9 pmol L(-1) (SEM 0.2, n=8) to 10.7 pmol L(-1) (SEM 0.5, n=8), whereas perfusion of long-chain triglycerides (180 mmol fatty acids) had a significantly greater effect, increasing peptide YY concentration from 8 6 pmol L(-1) (SEM 0.2, n=8) to 18.9 pmol L(-1) (SEM 2.4, n=8, P < 0.008). A smaller quantity of long-chain triglycerides (90 mmol fatty acids) increased plasma concentration of peptide YY from 7.4 pmol L(-1) (SEM 0.4, n=8) to 13.3 pmol L(-1) (SEM 1.5, n=8), whereas sucrose polyester (90 mmol fatty acids) did not change peptide YY concentration. In a previous study, we investigated gastrin-stimulated gastric acid output in response to these treatments. The correlation between increases in peptide YY in response to all treatments and the decrease in acid output was r=0.72 (n=48, P < 0.0001). These results show that both long-chain and medium-chain triglycerides, but not sucrose polyester, stimulate the release of peptide YY.


CONCLUSIONS
We speculate that peptide YY may play an important role in the inhibition of gastrin-stimulated gastric acid secretion by long-chain and medium-chain triglycerides.
Maas
M I
MI
University Hospital Nijmegen, The Netherlands.
Hopman
W P
WP
Katan
M B
MB
Jansen
J B
JB
D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004386:Duodenum; D004435:Eating; D005227:Fatty Acids / Q000008:administration & dosage*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D008297:Male; D019894:Peptide YY / Q000097:blood / Q000378:metabolism*; D010477:Perfusion; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014280:Triglycerides / Q000008:administration & dosage*
D000897:Anti-Ulcer Agents; D004041:Dietary Fats; D005227:Fatty Acids; D005755:Gastrins; D014280:Triglycerides; D019894:Peptide YY; D013395:Sucrose; C013692:sucrose polyester