Response of rat adrenal neuropeptide Y and tyrosine hydroxylase mRNA to acute stress is enhanced by long-term voluntary exercise.
Neuropeptide Y (NPY) and catecholamines are synthesized in response to stress. Adrenal NPY mRNA and tyrosine hydroxylase (TH) mRNA were measured by Northern analysis 2 h after a single 20 min bout of shaker stress in exercised and sedentary male Sprague-Dawley rats. Long-term exercise (18 weeks of voluntary wheel running) alone did not significantly alter adrenal NPY mRNA or TH mRNA levels. However, increases in stress-induced NPY and TH mRNA abundances were significantly enhanced by long-term exercise (P < 0.01). These results suggest that long-term physical activity may enhance the ability to synthesize NPY and catecholamines under conditions of stress.
Levenson
C W
CW
Department of Nutrition, Food and Movement Sciences, Florida State University, Tallahassee 32306-4340, USA. levenson@neuro.fsu.edu
Moore
J B
JB
D000313:Adrenal Medulla / Q000502:physiology*; D000818:Animals; D015152:Blotting, Northern; D002395:Catecholamines / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D008297:Male; D009478:Neuropeptide Y / Q000235:genetics*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000235:genetics / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D002395:Catecholamines; D009478:Neuropeptide Y; D012333:RNA, Messenger; D014446:Tyrosine 3-Monooxygenase