title: Cloning and sequencing of the cDNA encoding human neurotrypsin.
abstract: cDNA clones encoding human neurotrypsin have been isolated from a human fetal brain cDNA library using a PCR-amplified probe. The assembled cDNA sequence contains a 2625 bp open reading frame encoding a multidomain serine protease with an overall sequence identity of 82.5% to murine neurotrypsin. Surprisingly, the human neurotrypsin exhibits an additional scavenger receptor cysteine-rich repeat.
authors.affiliation: Institute of Biochemistry, University of Zurich, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Proba
authors.forename: T P
authors.initials: TP
authors.lastname: Gschwend
authors.forename: P
authors.initials: P
authors.lastname: Sonderegger
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology / Q000378:metabolism; D003001:Cloning, Molecular; D018076:DNA, Complementary; D015723:Gene Library; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; D012697:Serine Endopeptidases; C108493:neurotrypsin