title: Repair and processing events at DNA ends.
abstract: Cell nuclei contain several abundant enzymes that bind rapidly and avidly to exposed termini of DNA. The properties and physiological roles of such factors are described; they include poly (ADP-ribose) polymerase, DNA-dependent protein kinase, several DNA ligases and excision-repair enzymes. Telomeres normally seem shielded from these activities by telomere-binding proteins. If incomplete protection of telomeres occurred, the functions of the DNA end-specific enzymes would be relevant for processing of telomeres. This could include alternative pathways for telomere propagation in telomerase-negative cells.
authors.affiliation: Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK.
authors.forename: T
authors.initials: T
authors.lastname: Lindahl
authors.forename: D E
authors.initials: DE
authors.lastname: Barnes
authors.forename: A
authors.initials: A
authors.lastname: Klungland
authors.forename: V J
authors.initials: VJ
authors.lastname: Mackenney
authors.forename: P
authors.initials: P
authors.lastname: Schär
mesh_terms: D004247:DNA / Q000378:metabolism*; D011088:DNA Ligases / Q000378:metabolism; D004260:DNA Repair; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D009711:Nucleotides / Q000378:metabolism; D011064:Poly Adenosine Diphosphate Ribose / Q000096:biosynthesis; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D009711:Nucleotides; D011064:Poly Adenosine Diphosphate Ribose; D004247:DNA; D011065:Poly(ADP-ribose) Polymerases; D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases; D011088:DNA Ligases