title: Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea.
abstract: Four new triterpenoid compounds, 1-4, were isolated from the mycelium of a basidiomycete, Fomitella fraxinea, and their structures determined by spectroscopic analyses. Compounds 1-5 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with respective minimum inhibitory concentration (MIC) ranges of 35-75 and 90-130 microM.
authors.affiliation: Department of Applied Biological Science, Science University of Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Kitamura
authors.forename: Y
authors.initials: Y
authors.lastname: Mizushina
authors.forename: F
authors.initials: F
authors.lastname: Sugawara
authors.forename: K
authors.initials: K
authors.lastname: Sakaguchi
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000187:drug effects / Q000201:enzymology*; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019384:Nucleic Acid Synthesis Inhibitors; D051381:Rats; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors; D014315:Triterpenes