title: [Efficacy of ritonavir in HIV positive patients pretreated with nucleoside analogues].
abstract: The virologic and immunologic efficacy of ritonavir, an HIV protease inhibitor, was examined in 14 HIV-infected patients with a mean CD4+ cell count of 183 x 10(6)/l at baseline. All had been exposed to nucleoside analogs for longer than 6 months; and ritonavir was added to previous ongoing antiretroviral drugs. A mean reduction of 1.5 logs was seen in plasma viral load 4 weeks after began ritonavir, and 9 (64.3%) of 14 patients achieved undetectable levels (< 4,000 HIV-RNA copies/ml). A mean increase of 222 x 10(6) cells was observed in the CD4+ count. Nine (64.3%) individuals reported side effects, although they did not force to stop the medication. In conclusion, the addition of ritonavir seem to be a reasonable alternative strategy in patients with advanced HIV disease and heavy previous exposure to nucleoside analogs.
authors.affiliation: Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid.
authors.forename: M
authors.initials: M
authors.lastname: Gómez-Cano
authors.forename: V
authors.initials: V
authors.lastname: Soriano
authors.forename: R
authors.initials: R
authors.lastname: Polo
authors.forename: E
authors.initials: E
authors.lastname: Valencia
authors.forename: M
authors.initials: M
authors.lastname: Adrados
authors.forename: J
authors.initials: J
authors.lastname: González-Lahoz
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1; D006801:Humans; D008297:Male; D019438:Ritonavir / Q000627:therapeutic use*; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D019438:Ritonavir
vernacular_title: Eficacia del ritonavir en pacientes VIH+ previamente tratados con análogos de nucleósidos.