Clinical significance of serum P53 antibody in patients with gastric cancer.
The presence of serum p53 antibody has been reported to have prognostic significance in patients with breast and ovarian cancers. In order to clarify clinical and prognostic significance of p53 antibody in serum, we measured p53 antibody in patients with gastric cancer. Twenty-five patients with gastric cancer were examined as well as 9 patients with gastric polyp as controls. Eight of 25 patients (32%) with gastric cancer were positive for p53 antibody, while no patients with gastric polyp were positive in gastric polyp group (p < 0.05). The presence of p53 antibody was significantly associated with histology, liver metastasis and stage classification in gastric cancer (p < 0.05, respectively). Presence of liver metastasis, type of histology and presence of p53 antibody are independent prognostic factors (p < 0.05, respectively). The overall survival in patients with p53 antibody was significantly shorter survival than for those without antibody (p < 0.05%). These data suggest that p53 antibody serves as one of the prognostic factors in gastric cancer.
Shiota
G
G
Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Ishida
M
M
Noguchi
N
N
Takano
Y
Y
Oyama
K
K
Okubo
M
M
Katayama
S
S
Harada
K
K
Hori
K
K
Ashida
K
K
Kishimoto
Y
Y
Hosoda
A
A
Suou
T
T
Ito
H
H
Kawasaki
H
H
D000236:Adenoma / Q000097:blood / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D000368:Aged; D000906:Antibodies / Q000097:blood* / Q000276:immunology; D014408:Biomarkers, Tumor / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D009367:Neoplasm Staging; D011127:Polyps / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000097:blood* / Q000276:immunology
D000906:Antibodies; D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53