In vitro susceptibility of Staphylococcus aureus isolated from blood to currently used antistaphylococcal drugs.
Changes in antibiotic susceptibility was evaluated in 77 consecutive nosocomial clinical isolates of Staphylococcus aureus collected from 1986 to 1994 at the Umberto I Polyclinic of the University of Rome (63 isolates) and from 7 other Roman hospitals (14 isolates). Oxacillin resistance in these isolates increased from 39% during the 1980s to 69% during the 1990s. Significant increases in resistance to ciprofloxacin, clindamycin and rifampicin were observed among oxacillin-resistant strains. No resistance to glycopeptides was observed although both teicoplanin and vancomycin had slightly reduced antistaphylococcal activity.
Baiocchi
P
P
Department of Clinical Medicine, University of Rome La Sapienza, Italy.
Galiè
M
M
Santini
C
C
Carfagna
P
P
Cassone
M
M
Tarasi
D
D
Venditti
M
M
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006020:Glycopeptides; D006801:Humans; D007558:Italy; D010068:Oxacillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D015610:Serum Bactericidal Test; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000904:Antibiotics, Antitubercular; D006020:Glycopeptides; D010406:Penicillins; D002981:Clindamycin; D002939:Ciprofloxacin; D010068:Oxacillin; D012293:Rifampin