Effects of metallic antioxidants on cadmium-catalyzed peroxidation of arachidonic acid.
In the present study, the reaction mixtures (cadmium chloride with arachidonic acid) were preincubated at 37 degrees C for 24 h prior to the measurement of malondialdehyde (MDA) by high performance liquid chromatography (HPLC). The cadmium-catalyzed reactions were also compared to those in the presence of selenium (Se), zinc (Zn) or germanium (Ge), metallic antioxidants. Our results showed that the toxic effects of cadmium cause lipid peroxidation of arachidonic acid by the catalytic process. The addition of metallic antioxidants to the reaction mixtures, might be useful in protecting against Cd-induced lipid peroxidation.
Yiin
S J
SJ
Ta Jen Junior College of Pharmacy, Pintung, Taiwan, ROC.
Lin
T H
TH
D000975:Antioxidants / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000737:chemistry*; D019256:Cadmium Chloride / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005857:Germanium / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000032:analysis; D008670:Metals / Q000494:pharmacology*; D010084:Oxidation-Reduction; D012643:Selenium / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D000975:Antioxidants; D008670:Metals; D005857:Germanium; D016718:Arachidonic Acid; D008315:Malondialdehyde; D012643:Selenium; D015032:Zinc; D019256:Cadmium Chloride