title: Interleukin-1beta in plasma and synovial fluid in relation to radiographic changes in arthritic temporomandibular joints.
abstract: The aim of this study was to investigate the level of the cytokine IL-1beta in plasma and temporomandibular joint (TMJ) synovial fluid of patients with arthropathies, and to study the relation between IL-1beta levels of synovial fluid and plasma as well as radiographic changes of the TMJ. 31 patients with general disease, 14 with rheumatoid arthritis (RA) and 17 with various arthritides were included in the study. Synovial fluid and blood samples were collected, and an individualized tomography of the TMJ was performed. Detectable levels of IL-1beta were found in 5 out of 39 synovial fluids and in 10 out of 27 plasma samples. The presence of IL-1beta in both plasma and synovial fluid was more frequent in RA patients than in the non-RA group. The extension of radiographic erosion was significantly greater in joints with IL-1beta than in those without. Both the extension of erosion and grade of radiographic changes of the TMJ were greater in patients with detectable IL-1beta level of plasma than in patients without. Our study indicates that presence of IL-1beta in plasma and synovial fluid is related to radiographic changes of the TMJ.
authors.affiliation: Department of Clinical Oral Physiology, School of Dentistry, Karolinska Institute, Huddinge, Sweden. silvi.nordahl@swipnet.se
authors.forename: S
authors.initials: S
authors.lastname: Nordahl
authors.forename: P
authors.initials: P
authors.lastname: Alstergren
authors.forename: S
authors.initials: S
authors.lastname: Eliasson
authors.forename: S
authors.initials: S
authors.lastname: Kopp
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000097:blood / Q000000981:diagnostic imaging* / Q000378:metabolism; D015535:Arthritis, Psoriatic / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism; D001799:Blood Sedimentation; D001862:Bone Resorption / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis* / Q000097:blood; D008297:Male; D008335:Mandibular Condyle / Q000000981:diagnostic imaging; D008382:Marfan Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism; D013053:Spectrophotometry; D013166:Spondylitis / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism; D013582:Synovial Fluid / Q000737:chemistry*; D013701:Temporal Bone / Q000000981:diagnostic imaging; D013704:Temporomandibular Joint / Q000000981:diagnostic imaging; D013705:Temporomandibular Joint Disorders / Q000097:blood / Q000000981:diagnostic imaging* / Q000378:metabolism; D014056:Tomography, X-Ray
chemical_list: D007375:Interleukin-1