Specific inhibition of macrophage-derived proinflammatory cytokine synthesis with a tetravalent guanylhydrazone CNI-1493 accelerates early islet graft function posttransplant.
Hyon
S H
SH
Division of Transplantation, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Tracey
K J
KJ
Kaufman
D B
DB
D000818:Animals; D016207:Cytokines / Q000276:immunology; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D006084:Graft Rejection / Q000517:prevention & control; D006085:Graft Survival / Q000276:immunology*; D006835:Hydrazones / Q000008:administration & dosage*; D007249:Inflammation / Q000517:prevention & control*; D016381:Islets of Langerhans Transplantation; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D014184:Transplantation, Homologous; D000813:Anilides; D006146:Guanidines
D016207:Cytokines; D006835:Hydrazones; C097256:semapimod; D000813:Anilides; D006146:Guanidines