title: Trace alignment and some of its applications.
abstract: BACKGROUND
  Extra useful information can be extracted from a DNA chromatogram trace, over that contained in the base-called DNA sequence. Many sequencing applications can benefit from examination of these traces.
  
  
  RESULTS
  An algorithm, based on dynamic programming, for aligning a DNA chromatogram to a DNA sequence is described and implemented. Its applications to vector clipping, EST alignment and mutation detection are discussed.
authors.affiliation: Informatics Group, Sanger Centre, Cambridge, UK.
authors.forename: R
authors.initials: R
authors.lastname: Mott
mesh_terms: D000465:Algorithms; D001331:Automation; D004247:DNA; D018076:DNA, Complementary; D008432:Mathematical Computing; D009154:Mutation; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
chemical_list: D018076:DNA, Complementary; D004247:DNA