title: Migration resistant, blood-compatible plasticized polyvinyl chloride for medical and related applications.
abstract: Plasticized polyvinyl chloride (PVC), although not a blood-compatible polymer, is the material of choice for the manufacture of blood bags and hemodialysis tubing throughout the world. PVC is usually plasticized with di-(2-ethylhexyl phthalate) (DEHP) to impart flexibility and low temperature properties to the final product. DEHP belongs to a class of agents called hypolipidemic hepatocarcinogens, and it migrates in small quantities into the storage medium such as blood, plasma, or serum, resulting in a number of toxic effects. It has been shown that the migration resistance and blood compatibility of flexible PVC could be significantly improved by grafting polyethylene glycol (PEG), the most blood-compatible polymer known today, onto the surface of flexible PVC by the classical Williamson ether synthesis reaction. The technique is simple and versatile enough to produce blood-compatible, migration resistant PVC surfaces for many medical applications. The method may also find use for preventing plasticizer migration from PVC cling films and polyvinylidene chloride films used extensively in food packaging.
authors.affiliation: Polymer Chemistry Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
authors.forename: S
authors.initials: S
authors.lastname: Lakshmi
authors.forename: A
authors.initials: A
authors.lastname: Jayakrishnan
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000737:chemistry*; D001672:Biocompatible Materials; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D002273:Carcinogens / Q000737:chemistry / Q000378:metabolism; D004051:Diethylhexyl Phthalate / Q000737:chemistry / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D010968:Plasticizers / Q000737:chemistry / Q000378:metabolism; D010973:Platelet Adhesiveness / Q000187:drug effects; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology; D011143:Polyvinyl Chloride / Q000737:chemistry* / Q000378:metabolism; D011817:Rabbits; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D001672:Biocompatible Materials; D002273:Carcinogens; D010968:Plasticizers; D011092:Polyethylene Glycols; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate