A reexamination of the concurrent discrimination learning task: the importance of anterior inferotemporal cortex, area TE.
For 30 years, the concurrent discrimination learning task has figured prominently in studies used to determine the effects of medial temporal lobe damage in monkeys. However, the findings from these studies have been contradictory. We explored the contribution to concurrent discrimination performance of inadvertent damage to area TE by reexamining the behavioral data and histological material from monkeys with medial temporal lobe lesions previously tested in our laboratory. The amount of inadvertent damage to area TE was more predictive of impaired performance on the concurrent discrimination learning task than was the amount of damage to any medial temporal lobe structure, including the perirhinal cortex. These findings resolve earlier inconsistent findings regarding the concurrent discrimination learning task by demonstrating that performance on this task depends on area TE and not on perirhinal cortex or other medial temporal lobe structures.
Buffalo
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Graduate Program in Neurosciences, University of California, San Diego, La Jolla 92037, USA.
Stefanacci
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Squire
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Zola
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D000818:Animals; D001245:Association Learning / Q000502:physiology; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D003118:Color Perception / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology; D003867:Depth Perception / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology*; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*