title: Spatio-temporal working memory and frontal lesions in man.
abstract: The delayed-response paradigm is thought to be a marker of the activity of the dorsolateral convexity of primates' prefrontal cortex, as this procedure requires the activation of working memory processes. Although the role of the dorsolateral prefrontal cortex (DLPC) in working memory seems to be well established, much remains to be understood about the processes this structure actually controls: encoding domain-specific information, its retention in short-term memory, its monitoring in working memory, or its selection and retrieval when a specific response program is required. To clarify the role of the DLPC in delayed-response tasks in humans, a set of sequencing paradigms was designed which incorporates the dissociation of (1) spatial and temporal parameters, (2) recall and recognition processes, and (3) the presence or absence of a delay. Performance of a group of patients with DLPC lesions (n = 8) was compared to that of age-matched normal subjects (n = 8). To verify the specificity of the results obtained for the DLPC lesioned patients, the performance of patients with a temporal lobotomy was also studied (n = 10). A significant effect of the delay was observed only in patients with DLPC lesions, affecting both their spatial and spatio-temporal recall, whereas their spatio-temporal recognition was normal. These findings suggest that the DLPC plays a role in the retrieval of visuospatial information for guiding a response program.
authors.affiliation: Inserm U289, Paris.
authors.forename: C T
authors.initials: CT
authors.lastname: Ferreira
authors.forename: M
authors.initials: M
authors.lastname: Vérin
authors.forename: B
authors.initials: B
authors.lastname: Pillon
authors.forename: R
authors.initials: R
authors.lastname: Levy
authors.forename: B
authors.initials: B
authors.lastname: Dubois
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
mesh_terms: D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D005625:Frontal Lobe / Q000293:injuries* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D013028:Space Perception / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*; D014057:Tomography, X-Ray Computed