Cellular senescence: lessons from yeast for human aging?
Recent results point to an important role for the nucleolus in the senescence of yeast cells. A further report suggests that the formation and preferential accumulation in mother cells of extrachromosomal rDNA circles is a cause of aging in yeast; this may be an ancient and conserved mechanism of senescence.
Shore
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Department of Molecular Biology, University of Geneva, Switzerland.
D000375:Aging; D002466:Cell Nucleolus / Q000235:genetics; D016922:Cellular Senescence / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000502:physiology; D005111:Extrachromosomal Inheritance / Q000235:genetics; D005656:Fungal Proteins / Q000502:physiology; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D016615:Telomere / Q000235:genetics; D015534:Trans-Activators / Q000502:physiology
D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D015534:Trans-Activators