title: Cytokines and adhesion molecules in allergic rhinitis.
abstract: This review summarizes our current knowledge of nasal allergic inflammation based on studies of cytokines, chemokines, and adhesion molecules in allergic rhinitis. The article also includes some aspects of viral rhinitis. Due to artificial or natural allergen exposure, an increase in the number of eosinophils and basophils, mast cells, IgE-positive cells, macrophages, monocyte-like cells, Langerhans cells, and activated T-cells can be observed within the mucosa and on the mucosal surface. Mediators are known to be released in response to allergens, but do not seem to be adequate to initiate the cell recruitment. After antigen challenge, the release of proinflammatory and regulatory cytokines could be demonstrated, and TH2-type cytokine mRNA upregulation in allergic mucosa has been shown. Proinflammatory cytokines initiate an adhesion cascade and activate T-cells that create an "atopic" cytokine environment within the tissue, which also may be linked to the long-term selective recruitment of eosinophils. However, the acute selective migration of eosinophils after allergen challenge is not fully understood, nor is the role of chemokines in allergic and viral rhinitis. Allergic rhinitis clearly represents an inflammatory reaction.
authors.affiliation: ENT Department, University Hospital Düsseldorf, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Bachert
authors.forename: M
authors.initials: M
authors.lastname: Wagenmann
authors.forename: G
authors.initials: G
authors.lastname: Holtappels
mesh_terms: D000485:Allergens / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology; D016207:Cytokines / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000502:physiology
chemical_list: D000485:Allergens; D015815:Cell Adhesion Molecules; D016207:Cytokines; D018836:Inflammation Mediators