title: Modulation of cutaneous SP receptors in atopic dermatitis after UVA irradiation.
abstract: Atopic dermatitis is a pruritic inflammatory skin disorder, involving immunological and non-immunological factors. Substance P seems to be involved in the pathogenesis of atopic dermatitis. Substance P-containing nerve fibers are increased in the lesional skin of patients with atopic dermatitis and a reduced weal and flare reaction to intradermal injection of substance P has been observed. We investigated the distribution of substance P receptors in the involved skin of patients before and after single or repetitive UVA irradiations. Our results indicate that substance P receptors of the NK-1 subtype are expressed on blood vessels and on epidermal keratinocytes of involved skin of patients with atopic dermatitis. UVA irradiations did not modify the epidermal distribution of substance P receptors but decreased their expression intensity on blood vessels. UVA irradiations seem to decrease skin inflammation through the modulation of NK-1 receptor expression on endothelial cells.
authors.affiliation: INSERM U 346, Pavillon. R, E. Herriot Hospital, Lyon, France.
authors.forename: V
authors.initials: V
authors.lastname: Staniek
authors.forename: C
authors.initials: C
authors.lastname: Liebich
authors.forename: E
authors.initials: E
authors.lastname: Vocks
authors.forename: S G
authors.initials: SG
authors.lastname: Odia
authors.forename: J D
authors.initials: JD
authors.lastname: Doutremepuich
authors.forename: J
authors.initials: J
authors.lastname: Ring
authors.forename: A
authors.initials: A
authors.lastname: Claudy
authors.forename: D
authors.initials: D
authors.lastname: Schmitt
authors.forename: L
authors.initials: L
authors.lastname: Misery
mesh_terms: D003876:Dermatitis, Atopic / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy*; D005786:Gene Expression Regulation / Q000528:radiation effects; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism / Q000528:radiation effects; D018040:Receptors, Neurokinin-1 / Q000378:metabolism* / Q000528:radiation effects*; D013373:Substance P / Q000378:metabolism* / Q000528:radiation effects*; D014467:Ultraviolet Therapy
chemical_list: D018040:Receptors, Neurokinin-1; D013373:Substance P