title: Differing characteristics of hepatitis B and C risk factors among elders in a rural area in Taiwan.
abstract: BACKGROUND
  Both hepatitis B and C are major health concerns in Taiwan. The goal of this study was to determine how risk factors for hepatitis B and C differed in this study population. It was also hoped that the data might help determine how age and place of residence affect hepatitis risk factors.
  
  
  METHODS
  Complete serum and hepatitis marker analysis (HBsAg and AntiHCV) was done for 282 individuals over 65 years old. Of these, 254 were interviewed for risk factor analysis.
  
  
  RESULTS
  Of the 282 subjects, 8.2% were HBsAg+, 27.3% were AntiHCV+, and 3.2% were both HBsAg+ and AntiHCV+. AntiHCV+ subjects were more likely than AntiHCV-subjects to have had frequent medical injections, odds ratio (OR) = 2.94, 95% confidence interval (CI) (1.68, 5.12), and it was the only independent risk factor for determining AntiHCV+, OR = 3.26, 95% CI (1.85, 6.11) (N = 254). The AntiHCV+ group had higher alanine and asparate aminotransferase levels but lower cholesterol and triglyceride levels than AntiHCV- and HBsAg+ groups (p < .0001). Abnormal ALT existed in 40.3% of AntiHCV+ and 10.7% of AntiHCV- cases. ALT was associated with AntiHCV and sex, although abnormal AST was only associated with AntiHCV.
  
  
  CONCLUSIONS
  AntiHCV was closely related with frequent medical injections and was the primary risk factor for abnormal ALT and AST levels in this study population. It appears that frequent medical injections are an important risk factor because of the previously common habit of reusing syringes. This is of major concern to elders in Taiwan because of their much greater likelihood of repeated exposure.
authors.affiliation: A-Lein Community Health Center, Taiwan, Republic of China.
authors.forename: C S
authors.initials: CS
authors.lastname: Wang
authors.forename: T T
authors.initials: TT
authors.lastname: Chang
authors.forename: P
authors.initials: P
authors.lastname: Chou
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood / Q000276:immunology / Q000502:physiology*; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D005163:Factor Analysis, Statistical; D005260:Female; D006509:Hepatitis B / Q000209:etiology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006526:Hepatitis C / Q000209:etiology*; D018937:Hepatitis C Antibodies / Q000032:analysis; D006801:Humans; D007267:Injections / Q000009:adverse effects; D008297:Male; D012307:Risk Factors; D012424:Rural Population; D013624:Taiwan
chemical_list: D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase