title: Dermatomyositis: a dermatology-based case series.
abstract: BACKGROUND
  Dermatomyositis is associated with significant morbidity and occasional mortality. Currently there is no consensus on treatment for patients with dermatomyositis.
  
  
  OBJECTIVE
  Our purpose was to review the clinical features and response to therapy of patients with dermatomyositis and compare these data with previous series of patients with dermatomyositis/polymyositis.
  
  
  METHODS
  Clinical characteristics of 65 patients seen during a 10-year period were reviewed retrospectively. Twenty-one of these patients were enrolled in a prospective, uncontrolled study of treatment with high-dose prednisone followed by slow tapering.
  
  
  RESULTS
  Clinical features were similar to those previously described; however, muscle strength at diagnosis was on average greater in patients in this series than in patients previously reported. Malignancy was present in 5 of 43 adult patients (12%), but was not found in patients with juvenile dermatomyositis. Another connective tissue disease was present in 19% of patients. Twelve patients had dermatomyositis sine myositis. Eighteen of 21 patients (85%) in the prednisone study group had resolution of myositis.
  
  
  CONCLUSIONS
  Patients with dermatomyositis in this series had less active myositis at presentation, but were otherwise similar to patients with dermatomyositis/polymyositis previously reported. Treatment with high-dose daily prednisone followed by slow tapering was effective.
authors.affiliation: Department of Dermatology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157-1071, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Dawkins
authors.forename: J L
authors.initials: JL
authors.lastname: Jorizzo
authors.forename: F O
authors.initials: FO
authors.lastname: Walker
authors.forename: D
authors.initials: D
authors.lastname: Albertson
authors.forename: S H
authors.initials: SH
authors.lastname: Sinal
authors.forename: A
authors.initials: A
authors.lastname: Hinds
mesh_terms: D000328:Adult; D002648:Child; D003882:Dermatomyositis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D011241:Prednisone / Q000008:administration & dosage*; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology
chemical_list: D011241:Prednisone