A novel DRB1*0801 haplotype carrying DRB3*0202 found in a German pedigree.
DRB1*08 haplotypes have not been known to carry a DRB3 gene. We have found a patient suffering from liver disease who has a novel HLA haplotype of DRB1*0801 with DRB3*0202 as established by family segregation. These two genes were confirmed by sequencing. DR8 and DR52 antigen specificities were serologically detected, indicating expression of these genes.
Chen
D F
DF
Blutbank-Immunhämatologie-Transfusionsmedizin, Medizinische Hochschule Hannover, Germany.
Pastucha
L T
LT
Albert
E D
ED
Seibert
I
I
Volgger
A
A
Yao
Z
Z
Pein
C D
CD
Tillmann
H L
HL
Manns
M P
MP
Stangel
W
W
D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics; D005858:Germany; D006684:HLA-DR Antigens / Q000032:analysis / Q000097:blood / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008107:Liver Diseases / Q000235:genetics / Q000276:immunology; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C041559:HLA-DR8 antigen; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains