Effects of lormetazepam on glycemia and serum lipids in hyperlipidemic rats.
Lormetazepam (N-methyllorazepam) administered intraperitoneally to rats rendered hyperlipidemic by Triton WR-1339 induced an elevation of blood glucose level at all investigated doses. It brought about significant reduction of serum total lipids, total cholesterol and triglycerides. The dose-response relationship was bell-shaped. However, it presented two peaks, differing from the responses to other benzodiazepines (BZD) which were characterized by only one peak.
Horák
J
J
Department of Pharmacology, Faculty of Medicine, University of Oradea, Romania.
Horák
A
A
Lenghel
A
A
Cuparencu
B
B
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D001569:Benzodiazepines; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006949:Hyperlipidemias / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008140:Lorazepam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D014151:Anti-Anxiety Agents; D001786:Blood Glucose; D000960:Hypolipidemic Agents; D008055:Lipids; D014280:Triglycerides; D001569:Benzodiazepines; D002784:Cholesterol; C023842:lormetazepam; D008140:Lorazepam