title: Levels of soluble Fas in patients with myocarditis, heart failure of unknown origin, and in healthy volunteers.
abstract: This study showed that serum levels of sFas were elevated in patients with myocarditis, and that this elevation was correlated with sIL-2R level as a marker of T-cell activation. Therefore, sFas levels may be associated with T-cell activation in patients with myocarditis, and elevation of sFas may inhibit apoptosis in activated T cells, leading to persistent cell-mediated destruction of myocytes in myocarditis.
authors.affiliation: Division of Pathology, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Toyozaki
authors.forename: M
authors.initials: M
authors.lastname: Hiroe
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Iijima
authors.forename: H
authors.initials: H
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Hiroshima
authors.forename: H
authors.initials: H
authors.lastname: Kohno
authors.forename: S
authors.initials: S
authors.lastname: Ishiyama
authors.forename: F
authors.initials: F
authors.lastname: Marumo
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: H
authors.initials: H
authors.lastname: Ohwada
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis; D016022:Case-Control Studies; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D009205:Myocarditis / Q000097:blood*; D016133:Polymerase Chain Reaction / Q000379:methods; D012333:RNA, Messenger / Q000032:analysis; D012194:RNA-Directed DNA Polymerase; D015375:Receptors, Interleukin-2 / Q000097:blood; D012720:Severity of Illness Index; D019014:fas Receptor / Q000097:blood* / Q000235:genetics
chemical_list: D008565:Membrane Proteins; D012333:RNA, Messenger; D015375:Receptors, Interleukin-2; D019014:fas Receptor; D012194:RNA-Directed DNA Polymerase