Towards development of T-cell vaccines.
Recent studies on the recognition of antigens by CD4+ and CD8+ T cells have revealed new ways of preparing efficient T-cell vaccines. Here, Constantin Bona and colleagues discuss several approaches for the development of T-cell vaccines, with applications ranging from the induction of protective immunity against intracellular parasites to the development of therapeutic agents against autoimmune disorders, allergic diseases and cancer.
Bona
C A
CA
Mount Sinai School of Medicine, Dept of Microbiology, New York, NY 10029, USA. bona@msvax.mssm.edu
Casares
S
S
Brumeanu
T D
TD
D000818:Animals; D004247:DNA / Q000276:immunology; D016503:Drug Delivery Systems; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006801:Humans; D018448:Models, Immunological; D011994:Recombinant Proteins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology / Q000627:therapeutic use
D018984:Epitopes, T-Lymphocyte; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D004247:DNA