title: Acute quadriplegia with delayed onset and rapid recovery. Case report.
abstract: The authors describe a patient with severe head injury and sepsis who became acutely quadriplegic 3 days postinjury because of a critical illness polyneuropathy (CIP) and critical illness myopathy (CIM), which resolved rapidly after treatment of the underlying infection. In only 3 days the patient developed septic shock together with flaccid quadriplegia and absent deep tendon reflexes with no clinical or radiological evidence of central nervous system deterioration. Neurophysiological studies showed an acute axonal sensorimotor polyneuropathy, whereas the clinical course strongly suggested a concurrent myopathy. A severe Staphylococcus epidermidis infection accompanied by bacteremia was treated and the patient recovered fully within a few days. Although the case described here is unique because of its very early onset and rapid resolution, CIP and CIM are frequent complications of sepsis and multiple organ failure. The authors suggest that severely head injured patients with sepsis should be evaluated for CIP and CIM when presenting with unexplained muscle weakness or paralysis.
authors.affiliation: Department of Anesthesiology-Intensive Care, University of Brescia, Spedali Civili, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Latronico
authors.forename: F A
authors.initials: FA
authors.lastname: Rasulo
authors.forename: D
authors.initials: D
authors.lastname: Recupero
authors.forename: A
authors.initials: A
authors.lastname: Beindorf
authors.forename: P
authors.initials: P
authors.lastname: Liberini
authors.forename: R
authors.initials: R
authors.lastname: Stefini
authors.forename: A
authors.initials: A
authors.lastname: Candiani
mesh_terms: D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006259:Craniocerebral Trauma / Q000150:complications / Q000601:surgery; D016638:Critical Illness; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000150:complications; D010523:Peripheral Nervous System Diseases / Q000150:complications; D011183:Postoperative Complications; D011782:Quadriplegia / Q000209:etiology* / Q000503:physiopathology*; D012772:Shock, Septic / Q000209:etiology; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents