title: An ancient system of host defense.
abstract: Research over the past few years has begun to provide significant advances in our understanding of the interplay between the innate and adaptive immune systems. New findings in several model systems reveal remarkable parallels and conservation of ancient host defense pathways in organisms separated by over a billion years of evolution.
authors.affiliation: Section of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: R
authors.initials: R
authors.lastname: Medzhitov
authors.forename: C A
authors.initials: CA
authors.lastname: Janeway
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004330:Drosophila / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008322:Mammals / Q000276:immunology; D010944:Plants / Q000276:immunology