title: Screening for neuroblastoma is ineffective in reducing the incidence of unfavourable advanced stage disease in older children.
abstract: Neuroblastoma exhibits many characteristics which would suggest that preclinical detection may improve outcome. The Quebec Neuroblastoma Screening Project was initiated to determine whether mass screening could reduce mortality in a large cohort of infants. All 476,603 children born in the province of Quebec during a 5-year period of time (1 May 1989 to 30 April 1994) were eligible for determinations of urinary catecholamine metabolites at 3 weeks and 6 months of age. Children with positive screening were referred to one of four paediatric cancer centres in Quebec for uniform evaluation and treatment. Standardised incidence ratios (SIRs) were calculated for neuroblastoma in Quebec and two comparable population-based controls during the same period of time using similar ascertainment procedures. Compliance with screening in Quebec was 91% at 3 weeks (n = 425,816) and 74% at 6 months (n = 349,706). Up to 31 July 1995 with a follow-up of the birth cohort of 15-75 months, 118 cases of neuroblastoma were diagnosed, 43 detected preclinically by screening, 20 detected clinically prior to screening at 3 weeks of age and 55 detected clinically after 3 weeks of age having normal screens (n = 52) or never screened (n = 3). Based on data from concurrent control populations, 54.5 cases of neuroblastoma would have been expected in Quebec during the study period for an SIR of 2.17 (95% CI 1.79-2.57, P < 0.0001). For the two control groups, the overall SIR was 1.00 (NS). SIRs for Quebec by age at diagnosis in yearly intervals show a marked increased incidence under 1 year of age (SIR = 2.85, 95% CI 2.26-3.50), with no reduction in incidence in subsequent years. We conclude that screening for neuroblastoma markedly increases the incidence in infants without decreasing the incidence of unfavourable advanced stage disease in older children. It is unlikely that screening for neuroblastoma in infants will reduce the mortality of this disease.
authors.affiliation: University of Minnesota, Minneapolis, USA.
authors.forename: W G
authors.initials: WG
authors.lastname: Woods
authors.forename: M
authors.initials: M
authors.lastname: Tuchman
authors.forename: L L
authors.initials: LL
authors.lastname: Robison
authors.forename: M
authors.initials: M
authors.lastname: Bernstein
authors.forename: J M
authors.initials: JM
authors.lastname: Leclerc
authors.forename: L C
authors.initials: LC
authors.lastname: Brisson
authors.forename: J
authors.initials: J
authors.lastname: Brossard
authors.forename: G
authors.initials: G
authors.lastname: Hill
authors.forename: J
authors.initials: J
authors.lastname: Shuster
authors.forename: R
authors.initials: R
authors.lastname: Luepker
authors.forename: T
authors.initials: T
authors.lastname: Byrne
authors.forename: S
authors.initials: S
authors.lastname: Weitzman
authors.forename: G
authors.initials: G
authors.lastname: Bunin
authors.forename: B
authors.initials: B
authors.lastname: Lemieux
authors.forename: G M
authors.initials: GM
authors.lastname: Brodeur
mesh_terms: D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008403:Mass Screening; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*; D010349:Patient Compliance