[Effects of mono- and combined peptic ulcer therapy on lipid peroxidation and antioxidant defense in ulcerous zone].
Lipid peroxidation and antioxidant activity in the margin and periulcerous zones of duodenal mucosa were investigated in 111 patients with duodenal ulcer before treatment and in periscar zone after chemotherapy allowing for Helicobacter pylori infection. In active ulcer lipid peroxidation was high while antioxidant activity was depressed. Helicobacter pylori was found able to initiate peroxidation. Pathogenetic therapy including antihelicobacter drugs inhibits activity of lipid peroxidation and promotes normalization of antioxidant activity of duodenal mucosa. This gives grounds for combined use of antisecretory and antichelicobacter medicines.
Esedov
E M
EM
Mamaev
S N
SN
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D016480:Helicobacter pylori; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D017382:Reactive Oxygen Species
Vliianie mono- i kombinirovannoĭ terapii iazvennoĭ bolezni na perekisnoe okislenie lipidov i antioksidantnuiu zashchitu v ul'tseroznoĭ zone.