[Epstein-Barr virus and cellular immortalization].
Epstein-Barr virus has been associated to several forms of neoplasia including Burkitt's lymphoma, B lymphomas in immuno-compromised patients and undifferentiated nasopharyngeal carcinoma. Immunodepression, genetic and/or environmental factors and the expression of several viral genes (latent genes mainly) may contribute to these pathologies. In vitro, several latent proteins (EBNA 1, 2, 3A, 3C, 5 et LMP-1) directly or indirectly contribute to the initiation and maintenance of the transformation process. The role of these proteins is discussed in the present article.
Marechal
V
V
Service de Microbiologie, Hôpital Rothschild, Paris.vmarechal@infobiogen.fr
Dehée
A
A
Nicolas
J C
JC
D000818:Animals; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral / Q000502:physiology*; D005814:Genes, Viral / Q000502:physiology*; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000502:physiology; D006801:Humans; D017735:Virus Latency
Virus Epstein-Barr et immortalisation cellulaire.