Ultrastructural study of the lateral lobe of the prostate of Wistar rats submitted to experimental chronic alcohol ingestion.
Alcoholism is considered today one of the most serious social and medical problems. Different investigators have demonstrated that chronic exposure to alcohol causes morphological and physiological changes in the testes and in the accessory sex glands, in the prostate in particular. In the present study, experimental rats were divided into groups receiving sugar cane brandy diluted to 30 degrees G.L. (30%, v/v) and Purina ration ad libitum for 60, 120, 180, 240 and 300 days, respectively. At the end of each period the animals were sacrificed and the lateral lobe of the prostate was collected for histological examination. The results showed atrophied epithelium, accumulation of lipidic droplets and rupture of the microvilli that line the cell surface facing the lumen of cells of the secretory epithelium of the lateral lobe of the prostate.
Cagnon
V H
VH
Department of Anatomy, Institute of Biology, State University of Campinas, UNICAMP, São Paulo.
Garcia
P J
PJ
Guazzelli Filho
J
J
Martinez
F E
FE
Mello
W
W
Martinez
M
M
D000437:Alcoholism / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D000431:Ethanol / Q000633:toxicity; D005837:Genitalia, Male / Q000187:drug effects / Q000648:ultrastructure; D050356:Lipid Metabolism; D008297:Male; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D011467:Prostate / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000431:Ethanol