title: [Peri-infarct angiographic behavior of "non-culprit" coronary infarct lesions].
abstract: Because systemic factors, such as lipoproteins, autoantigens, infectious agents, may facilitate plaque rupture, thrombus formation and coronary occlusion, the question may arise of whether thrombosis be only a local plaque event or the consequence of an acute activity of the entire coronary tree. Taking changes at the narrowest point of non culprit lesions as reflecting progression or regression of the disease when > 0.27 mm, early (within a few days) and late (within 1 month) coronarographic findings in 23 patients with first infarction were compared with those of patients with stable angina, in whom coronary angiography was performed for diagnostic purposes and was repeated 1 month later, before angioplasty. Sixteen infarction patients had progression, 4 had regression, 1 had both, and 2 had steadiness; corresponding values in stable angina group were 2 (p < 0.001), 1 (NS), 0 (NS) and 20 (p < 0.001). In the infarction group, 17 out of the 45 non culprit lesions progressed and 5 regressed; corresponding figures in stable angina group were 2 (p < 0.001) and 1 (p < 0.05). Three of the infarction patients developed interim angina at rest that was associated with progression of a culprit lesion in each of them. These results support the hypothesis that in a number of cases infarction may not reflect an arbitrary plaque event but rather a systemic coronary disease activity with maximal expression at the level of the offending plaque.
authors.affiliation: Istituto di Cardiologia, Università degli Studi, Milano.
authors.forename: A
authors.initials: A
authors.lastname: Loaldi
authors.forename: M
authors.initials: M
authors.lastname: Bussotti
authors.forename: L
authors.initials: L
authors.lastname: Grancini
authors.forename: M
authors.initials: M
authors.lastname: Guazzi
authors.forename: I L
authors.initials: IL
authors.lastname: Pera
authors.forename: N B
authors.initials: NB
authors.lastname: de Cesare
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*
vernacular_title: Comportamento angiografico perinfartuale delle lesioni coronariche "non colpevoli" di infarto.