Induction of mucosal B-cell memory by intramuscular inoculation of mice with rotavirus.
We investigated the capacity of intramuscular (i.m.) immunization with heterologous-host rotavirus (simian strain RRV) to induce mucosal virus-specific memory B cells in mice. We found that prior i.m. immunization enhanced the magnitude of mucosal virus-specific immunoglobulin A (IgA) production but did not alter the site and timing of induction of virus-specific IgA responses after challenge.
Coffin
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Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, and The University of Pennsylvania School of Medicine, 19104, USA. coffin@email.chop.edu
Offit
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PA
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D000882:Haplorhini; D018928:Immunity, Mucosal / Q000276:immunology; D007070:Immunoglobulin A / Q000096:biosynthesis; D007156:Immunologic Memory / Q000276:immunology*; D007273:Injections, Intramuscular; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*
D000914:Antibodies, Viral; D007070:Immunoglobulin A