title: The use of propofol as an induction agent for halothane and isoflurane anesthesia in dogs.
abstract: Cardiovascular, pulmonary, and quantitative electroencephalographic parameters were assessed in 12 anesthetized dogs to determine the compatibility of the injectable anesthetic propofol with halothane and isoflurane. No cases of apnea were observed during induction of anesthesia. An adequate level of anesthesia was established in each protocol as judged by both the lack of response to mechanical noxious stimuli (i.e., tail clamping) and evidence of reduction in total amplitude of brain wave activity. The initial propofol-mediated decrease in arterial blood pressure continued during either halothane (52.4%) or isoflurane (38%) anesthesia without a simultaneous increase in heart rate. The results of this study suggest that propofol, in combination with inhalant agents, can be used effectively and safely for canine anesthesia in veterinary practice.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
authors.forename: A
authors.initials: A
authors.lastname: Bufalari
authors.forename: S M
authors.initials: SM
authors.lastname: Miller
authors.forename: C
authors.initials: C
authors.lastname: Giannoni
authors.forename: C E
authors.initials: CE
authors.lastname: Short
mesh_terms: D000704:Analysis of Variance; D000769:Anesthesia, Inhalation / Q000379:methods / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D004569:Electroencephalography / Q000187:drug effects / Q000662:veterinary; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D007530:Isoflurane / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010146:Pain; D015742:Propofol / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D013990:Tidal Volume / Q000187:drug effects
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D002245:Carbon Dioxide; D007530:Isoflurane; D010100:Oxygen; D006221:Halothane; D015742:Propofol