Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice.
To evaluate the cognitive phenotype of the segmental trisomy 16 (Ts65Dn) mouse, a model of Down Syndrome (DS, trisomy 21), we assessed spatial working and reference memory using a 12-arm radial maze (RAM). Ts65Dn mice made a greater number of reference memory errors across trials compared to control mice. Both genotypes showed improvement across trials, although improvement was slower in Ts65Dn mice. Ts65Dn mice also made a greater number of working memory errors on the RAM, and in contrast to control mice, did not improve across trials, always performing at near-chance levels. These results provide evidence for both spatial working and reference memory deficits in Ts65Dn mice, characteristics of cognitive dysfunction.
Demas
G E
GE
Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA. demas@ren.psy.jhu.edu
Nelson
R J
RJ
Krueger
B K
BK
Yarowsky
P J
PJ
D000818:Animals; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000235:genetics* / Q000523:psychology; D051379:Mice; D008818:Mice, Neurologic Mutants; D013028:Space Perception / Q000502:physiology*; D014314:Trisomy / Q000235:genetics* / Q000503:physiopathology*