Comparative experimental study of Mg lactate, vitamin B6 and their association on the permeability of a human membrane. 1. Effect on the total ionic transfer through isolated amniotic membrane.
The effects of Mg lactate, vitamin B6 and their association were studied on the ionic transfer through a membranous model: the human isolated amniotic membrane. The ionic transfer was evaluated by measuring of the total conductance in the maternal to fetal way (GtM) and in the fetal to maternal way (GtF) and of the ionic fluxes (F1 on the maternal side, F2 on the fetal side) and of the ratio F1/F2. Whatever the concentration, Mg lactate decreased GtM, F1, F2, F1/F2 but had a concentration-dependent effect on GtF. Vitamin B6 had no significant effect on GtF, F1, F2, F1/F2, but decreased GtM whatever its concentration. The association Mg lactate + vitamin B6 presented a biphasic action on GtM, GtF, F1, F2 and F1/F2: decrease at low ratio and increase from ratio equal to 8. This association induced interesting effect in the case of therapeutic use in comparison with the effects of separated compounds.
Bara
M
M
Laboratory of Physiopathologie de l'Implantation et du Développement, University P.M. Curie, Paris, France. Michel.Bara@snv,jussieu.fr
Guiet-Bara
A
A
Durlach
J
J
D000650:Amnion / Q000187:drug effects / Q000378:metabolism*; D001692:Biological Transport; D002463:Cell Membrane Permeability / Q000187:drug effects*; D005260:Female; D006801:Humans; D007223:Infant; D007477:Ions; D019344:Lactic Acid / Q000378:metabolism / Q000494:pharmacology*; D008274:Magnesium / Q000378:metabolism / Q000494:pharmacology*; D011247:Pregnancy; D011736:Pyridoxine / Q000378:metabolism / Q000494:pharmacology*
D007477:Ions; D019344:Lactic Acid; D008274:Magnesium; D011736:Pyridoxine