A single dose of methamphetamine in neonatal gerbils affects adult prefrontal gamma-aminobutyric acid innervation.
A single non-invasive dose of methamphetamine (50 mg/kg i.p.) was administered to neonatal male gerbils (Meriones unguiculatus) aged 14 days. At the age of postnatal day 90, the gamma-aminobutyric acid (GABA) immunoreactive profiles were electron microscopically quantified in the prelimbic area of the prefrontal cortex and compared with those of saline-treated controls. This early solitary drug challenge resulted in adult GABAergic innervation densities which were approximately 40% above those of saline-treated controls.
Nossoll
M
M
Department of Neuroanatomy, Faculty of Biology, University of Bielefeld, Germany.
Teuchert-Noodt
G
G
Dawirs
R R
RR
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D005849:Gerbillinae; D007150:Immunohistochemistry; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008854:Microscopy, Electron; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000502:physiology*
D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D005680:gamma-Aminobutyric Acid