title: Pathological investigation of armadillos infected with Mycobacterium leprae.
abstract: An infection experiment with M. leprae was carried out using 20 nine-banded armadillos. As a result, the development of leprous lesions and a marked multiplication of AFB were confirmed in a high rate of 13 out of 15 cases (86.8%) in the inoculated groups. These changes were found to be progressing at post mortem of one case even with the shortest life period for 7.5 months and were very serious in one case with the longest life period for 33 months, suggesting the continuation of symptoms, though it is an expression neglecting the individual difference in susceptibility to leprosy. Among infected viscera with AFB, the most conspicuous lesions were found in the liver and spleen. The developed lesions were found in the lung, stomach and kidney which had been never seen in HD in human cases, and so, which may characterize armadillos' leprosy. The change in the peripheral nerve was not so severe when compared with that in HD in human cases. This difference will remain as a future pathological problem to be solved.
authors.affiliation: Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Kawatsu
authors.forename: S
authors.initials: S
authors.lastname: Tsutsumi
authors.forename: M
authors.initials: M
authors.lastname: Gidoh
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kashiwabara
authors.forename: G
authors.initials: G
authors.lastname: Matsuki
authors.forename: H
authors.initials: H
authors.lastname: Endo
mesh_terms: D000818:Animals; D001135:Armadillos; D004195:Disease Models, Animal; D007918:Leprosy / Q000473:pathology*