Perivascular localization of nitric oxide synthase in the rat adenohypophysis: potential implications for function and cell-cell interaction.
The possible localization of nitric oxide (NO) synthase (NOS) in proximity to the microvasculature was examined in the rat adenohypophysis using immunohistochemistry and nicotinamide adenine dinucleotide phosphate diaphorase histochemistry. A population of NOS-positive cells was localized in very close contact with the sinusoidal capillaries. The pattern of this perivascular localization was either unicellular, bicellular or multicellular. These observations suggest that, at least, some actions of NO in the adenohypophysis can be accounted for by a local regulation of the glandular microvasculature.
Okere
C O
CO
Department of Physiology, Kochi Medical School, Nankoku, Kochi 783, Japan.
Murata
E
E
Higuchi
T
T
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D008833:Microcirculation / Q000201:enzymology; D009252:NADPH Dehydrogenase / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar
D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase