Betablockers: old concept in a modern approach.
In summary, carvedilol lowers blood pressure effectively. There is a decrease in left ventricular mass. Carvedilol has a good metabolic profile and seems to improve insulin sensitivity. Through its effects on the endothelial function and its antioxidative properties carvedilol has positive effects on the atherosclerotic process. Carvedilol also decreases microalbuminuria. In several aspects carvedilol differs from the conventional beta-blocking drugs, and some of these effects are now being investigated in new studies.
Hansson
B G
BG
Department of Internal Medicine, Regional Hospital, Halmstad, Sweden.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D000077261:Carvedilol; D006801:Humans; D011412:Propanolamines / Q000494:pharmacology / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol