Effect of metoprolol in reducing myocardial ischemic threshold during exercise and during daily activity.
In a study of 48 patients with coronary artery disease and evidence of ischemia during exercise and daily life, metoprolol reduced the threshold of myocardial ischemia in a dose-dependent manner. This effect of beta blockers is probably due to increased coronary tone.
Tzivoni
D
D
Department of Cardiology, Shaare Zedek Medical Center, and Bikur Cholim Hospital, Jerusalem, Israel.
Medina
A
A
David
D
D
Barzilai
Y
Y
Brunel
P
P
D000203:Activities of Daily Living; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D001794:Blood Pressure; D004305:Dose-Response Relationship, Drug; D015716:Electrocardiography, Ambulatory; D015444:Exercise; D006339:Heart Rate; D006801:Humans; D008790:Metoprolol / Q000494:pharmacology*; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000517:prevention & control*
D000319:Adrenergic beta-Antagonists; D008790:Metoprolol