title: Pretreatment of skin with a Ginkgo biloba extract/sodium carboxymethyl-beta-1,3-glucan formulation appears to inhibit the elicitation of allergic contact dermatitis in man.
abstract: The clinical efficiency of mitigating contact dermatitis with a Ginkgo biloba extract and carboxymethyl-beta-1,3-glucan formulation was investigated in a double-blind versus placebo study using 22 subjects (Caucasian women aged 22-55 years) with allergic contact dermatitis from various substances in the European standard series. The formulation was applied to intact skin 2X a day for 2 weeks ("in use" application) prior to a single application of a selected contact allergen under a Finn Chamber for 24 h. Readings were carried out in a blind study by a dermatologist 2 and 3 days after patch removal. Representative photographs were taken of treated, placebo and untreated test areas. 68.2% of the panelists showed significantly reduced skin reactivity (p = 0.037*) on the treated site 2 days after patch removal, versus untreated and/or placebo sites. This finding indicates that the Ginkgo biloba/carboxymethyl-beta-1,3-glucan formulation can mitigate against allergic contact dermatitis.
authors.affiliation: RoC Laboratoires de Dermo-esthétique, Colombes, France.
authors.forename: D
authors.initials: D
authors.lastname: Castelli
authors.forename: L
authors.initials: L
authors.lastname: Colin
authors.forename: E
authors.initials: E
authors.lastname: Camel
authors.forename: G
authors.initials: G
authors.lastname: Ries
mesh_terms: D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000473:pathology / Q000517:prevention & control*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D020441:Ginkgo biloba; D005936:Glucans / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009824:Ointments / Q000627:therapeutic use; D010328:Patch Tests; D010936:Plant Extracts; D017592:Skin Care; D016896:Treatment Outcome; D047071:beta-Glucans; D000096983:Ginkgo Extract
chemical_list: D004338:Drug Combinations; D005419:Flavonoids; D016166:Free Radical Scavengers; D005936:Glucans; D009824:Ointments; D010936:Plant Extracts; D047071:beta-Glucans; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract; C029933:carboxymethyl-beta-1,3-glucan