title: Rapid estimation of regurgitant volume by the proximal isovelocity surface area method in mitral regurgitation: Can continuous-wave Doppler echocardiography be omitted?
abstract: The proximal isovelocity surface area (PISA) method is accurate for quantitating mitral regurgitation but requires recording both mitral maximal and integrated jet velocities using the same continuous-wave Doppler jet signal. In 272 consecutive patients with isolated mitral regurgitation, the mean ratio of maximal to integral of velocity had a narrow range of variation (mean +/- SD, 3.25 +/- 0.47). The estimated regurgitant volume, calculated as regurgitant flow/3.25, showed an excellent correlation with reference regurgitant volumes (r = 0.96 and r = 0.97; standard error of the estimate, 11 ml; both p < 0.0001), with limited overestimation and high sensitivity and specificity for severe mitral regurgitation. The estimated regurgitant volume is a useful measurement in patients in whom the continuous-wave Doppler signal of mitral regurgitation cannot be obtained.
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: A
authors.initials: A
authors.lastname: Rossi
authors.forename: K S
authors.initials: KS
authors.lastname: Dujardin
authors.forename: K R
authors.initials: KR
authors.lastname: Bailey
authors.forename: J B
authors.initials: JB
authors.lastname: Seward
authors.forename: M
authors.initials: M
authors.lastname: Enriquez-Sarano
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity