[Pathogenesis, diagnosis and therapy of heart disease caused by enteroviruses (molecular biological study)].
Molecular hybridization studies have demonstrated that human enteroviruses, including group B coxsackieviruses (CVB), are detectable in myocardial tissue of patients with acute and chronic myocarditis. As well, such infections are observed in some patients with end-stage dilated cardiomyopathy indicating the possibility of persistent heart muscle infection. Enterovirus persistence in the human heart is supported by the discovery in various murine models of chronic myocarditis, demonstrating that coxsackievirus B3 (CVB3), typically a cytolytic virus, is capable of evading immunological surveillance in a host-dependent manner. Currently attention is focused on the analysis of molecular mechanisms of virus persistence, the characterization of viral and host factors and their impact in determining the natural course of myocardial enterovirus infections. The evidence for a causal linkage of enterovirus infection with heart muscle diseases has emerged therapeutic implications. From the view of a virologist, immunosuppressive treatment of patients revealing enterovirus infection in the myocardium with steroids is clearly contraindicated. The evaluation of potent antiviral agents, such as interferons, in established in vitro and in vivo model systems of enterovirus infection is expected to contribute significantly to new therapeutic strategies in human enteroviral heart disease.
Klingel
K
K
Selinka
H C
HC
Zell
R
R
Mall
G
G
Bultmann
B
B
Kandolf
R
R
D000818:Animals; D009202:Cardiomyopathies / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D029822:Enterovirus B, Human / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000150:complications*; D006801:Humans; D051379:Mice
K patogenezu, diagnostike i terapii porazheniia serdtsa, vyzvannogo énterovirusami (molekuliarno-biologicheskoe issledovanie).