title: Absence of cross-reactivity of SR90107A/ORG31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopenia.
abstract: New carbohydrate-based anticoagulants devoid of the side effects of unfractionated heparin are currently under development and show a major potential for patients with heparin-induced thrombocytopenia (HIT) who still require efficient antithrombotic therapy. As HIT is usually associated with antibodies to heparin-platelet factor 4 (H-PF4) complexes, cross-reactivity of the heparin pentasaccharide SR90107A/ORG31540 was tested in the presence of PF4 with the plasma from 49 patients with HIT. No cross-reactivity was observed whatever the pentasaccharide concentrations. Although more extensive studies are required for excluding its total absence of immunogenicity and pathogenicity, this pentasaccharide is a candidate for use in emergency situations in patients with HIT.
authors.affiliation: Serbio Research Laboratory, Gennevilliers, France.
authors.forename: J
authors.initials: J
authors.lastname: Amiral
authors.forename: J C
authors.initials: JC
authors.lastname: Lormeau
authors.forename: A
authors.initials: A
authors.lastname: Marfaing-Koka
authors.forename: A M
authors.initials: AM
authors.lastname: Vissac
authors.forename: M
authors.initials: M
authors.lastname: Wolf
authors.forename: C
authors.initials: C
authors.lastname: Boyer-Neumann
authors.forename: B
authors.initials: B
authors.lastname: Tardy
authors.forename: J M
authors.initials: JM
authors.lastname: Herbert
authors.forename: D
authors.initials: D
authors.lastname: Meyer
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005343:Fibrinolytic Agents / Q000276:immunology* / Q000627:therapeutic use; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D046911:Macromolecular Substances; D008297:Male; D009844:Oligosaccharides / Q000276:immunology* / Q000627:therapeutic use; D010978:Platelet Factor 4 / Q000276:immunology*; D011182:Postoperative Care; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology*; D013927:Thrombosis / Q000188:drug therapy
chemical_list: D001323:Autoantibodies; D005343:Fibrinolytic Agents; D046911:Macromolecular Substances; D009844:Oligosaccharides; C064764:PENTA; D010978:Platelet Factor 4; D006493:Heparin