Characterization of FOX-3, an AmpC-type plasmid-mediated beta-lactamase from an Italian isolate of Klebsiella oxytoca.
Klebsiella oxytoca 1731, which showed a wide spectrum of resistance to beta-lactams, including cefoxitin, was isolated in 1994 from a patient in Genoa, Italy. This strain contained a plasmid-mediated AmpC beta-lactamase with a pI of 7.25. Sequencing of the corresponding DNA of K. oxytoca 1731 revealed 96 and 97% identities of the deduced amino acid sequence with FOX-1 and FOX-2, respectively.
Marchese
A
A
Istituto Di Microbiologia, Genoa, Italy.
Arlet
G
G
Schito
G C
GC
Lagrange
P H
PH
Philippon
A
A
D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D005260:Female; D006801:Humans; D007558:Italy; D007709:Klebsiella / Q000201:enzymology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D001618:beta-Lactamases / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology
D001426:Bacterial Proteins; D047090:beta-Lactams; C111085:FOX-3 protein, Klebsiella oxytoca; D001618:beta-Lactamases