title: Immunohistochemical localization of leptin receptor in the rat brain.
abstract: The distribution of leptin receptor in the rat brain was determined by immunocytochemistry and Western blotting. Strong leptin receptor immunoreactivity was detected in the arcuate, paraventricular and ventromedial nuclei of the hypothalamus, and lateral hypothalamic area. The olfactory bulb, neocortex, cerebellar cortex, dorsal raphe nucleus, inferior olive nucleus, nucleus of the solitary tract, dorsal motor nucleus of the vagus nerve also showed intense immunoreactivity. Western blotting analysis yielded a 120-kDa major band.
authors.affiliation: Department of Anatomy, Showa University School of Medicine, Tokyo, Japan. shioda@med.showa-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Shioda
authors.forename: H
authors.initials: H
authors.lastname: Funahashi
authors.forename: S
authors.initials: S
authors.lastname: Nakajo
authors.forename: T
authors.initials: T
authors.lastname: Yada
authors.forename: O
authors.initials: O
authors.lastname: Maruta
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
mesh_terms: D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000737:chemistry; D015153:Blotting, Western; D001923:Brain Chemistry / Q000502:physiology*; D002352:Carrier Proteins / Q000032:analysis*; D007026:Hypothalamic Area, Lateral / Q000737:chemistry; D007150:Immunohistochemistry; D008297:Male; D019579:Neocortex / Q000737:chemistry / Q000166:cytology; D009765:Obesity / Q000378:metabolism*; D011689:Purkinje Cells / Q000737:chemistry; D017966:Pyramidal Cells / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D014630:Vagus Nerve / Q000737:chemistry / Q000166:cytology
chemical_list: D002352:Carrier Proteins; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin