Comutagenesis--V: rapid conversion of 2-hydroxyl-amino-3-methylpyridineto 2-amino-3-methylpyridine by a hepatic S9 preparation.
The in vitro metabolism of 2-hydroxylamino-3-methylpyridine has been investigated using arochlor 1254 pretreated rat S9 mixtures. 2-Hydroxylamino-3-methylpyridine is rapidly converted to the parent amine 2-amino-3-methylpyridine. No further oxidation products of 2-hydroxylamino-3-methylpyridine (i.e. nitroso or nitro) were detected under the HPLC conditions used. This observation may explain our previous findings on the in vitro metabolism of 2-amino-3-methylpyridine where no hydroxylamino metabolite was detected.
Gorrod
J W
JW
Chelsea Department of Pharmacy, King's College London, University of London, UK.
Altuntas
T G
TG
D000631:Aminopyridines / Q000378:metabolism*; D000818:Animals; D001140:Aroclors / Q000378:metabolism; D020111:Chlorodiphenyl (54% Chlorine); D002851:Chromatography, High Pressure Liquid; D006898:Hydroxylamines / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D016296:Mutagenesis / Q000502:physiology*; D009153:Mutagens / Q000378:metabolism*; D010847:Picolines / Q000378:metabolism*; D011725:Pyridines / Q000378:metabolism*; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism
C111606:2-hydroxylamino-3-methylpyridine; D000631:Aminopyridines; D001140:Aroclors; D006898:Hydroxylamines; D009153:Mutagens; D010847:Picolines; D011725:Pyridines; D020111:Chlorodiphenyl (54% Chlorine); C109727:2-amino-3-methylpyridine