Magnesium deficiency exacerbates brain injury and stroke mortality induced by alcohol: a 31P-NMR in vivo study.
Mimicking in rats the reduced level of dietary magnesium (Mg) intake, seen in present-day Western World populations, short-term (4 weeks) restriction of Mg intake (30-35% normal) resulted in a 40% loss in brain intracellular free Mg2+ ions ([Mg2+]i) and significant rises in brain intracellular pH (pHi) and phosphocreatine ([PCr]) but no change in [ATP] or [Pi] as measured by 31P-NMR spectroscopy. Such Mg-deficient animals (serum Mg fell 65%), when given ED40 stroke doses of ethanol, demonstrated a 100% stroke mortality. These findings indicate that: 1) moderate, short-term Mg deficiency makes the brain vulnerable to hypoxic-lethal stroke insults induced by alcohol administration, and 2) brain [Mg2+]i appears to play an important role in finely regulating brain pHi and [PCr].
Altura
B M
BM
Department of Physiology, and The Center for Cardiovascular and Muscle Research, State University of New York Health Science Center at Brooklyn, 11203, USA.
Gebrewold
A
A
Zhang
A
A
Altura
B T
BT
Gupta
R K
RK
D000818:Animals; D001921:Brain / Q000378:metabolism; D001930:Brain Injuries / Q000139:chemically induced*; D002561:Cerebrovascular Disorders / Q000139:chemically induced* / Q000401:mortality*; D004032:Diet; D000431:Ethanol / Q000633:toxicity*; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000008:administration & dosage / Q000378:metabolism; D008275:Magnesium Deficiency / Q000150:complications*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D010710:Phosphates; D010725:Phosphocreatine; D000431:Ethanol; D008274:Magnesium