title: Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells.
abstract: The pleiotropic biological activities of interleukin-18 (IL-18) are mediated by IL-18 receptor (IL-18R). When the ligand binds to the IL-18R, IL-18R initiates a signaling cascade that results in the activation of nuclear factor kappa B (NF-kappa B). When mouse EL-4 cells were exposed to IL-18, IL-1 receptor-associated kinase (IRAK) was recruited to IL-18R and was phosphorylated. In addition, tumor necrosis factor receptor-associated factor-6 (TRAF6) was associated with IRAK. Therefore, we concluded that IL-18/IL-18R-mediated signaling may share the IRAK/TRAF6 pathway through NF-kappa B activation with the IL-1/IL-1 receptor system.
authors.affiliation: Fujisaki Institute, Hayashibara Biochemical Labs., Inc., Okayama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kojima
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: Y
authors.initials: Y
authors.lastname: Nishida
authors.forename: N
authors.initials: N
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Ikegami
authors.forename: M
authors.initials: M
authors.lastname: Kurimoto
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology*; D004789:Enzyme Activation; D053592:Interleukin-1 Receptor-Associated Kinases; D020382:Interleukin-18; D007378:Interleukins / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism* / Q000502:physiology; D011506:Proteins; D017472:Receptors, Interleukin-1 / Q000378:metabolism* / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013601:T-Lymphocytes / Q000201:enzymology / Q000378:metabolism; D048029:TNF Receptor-Associated Factor 6; D013945:Thymoma; D014407:Tumor Cells, Cultured
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; D020382:Interleukin-18; D007378:Interleukins; D016328:NF-kappa B; D011506:Proteins; D017472:Receptors, Interleukin-1; D018124:Receptors, Tumor Necrosis Factor; D048029:TNF Receptor-Associated Factor 6; D011494:Protein Kinases; D053592:Interleukin-1 Receptor-Associated Kinases