title: [Administration of combination therapy with synthetic pgf2alpha analogs and a dopamine agonist for the termination of unwanted pregnancy in pregnant dogs. A study of six cases].
abstract: Analogous to the study of Onclin and Verstegen of 1996 the combination of a dopamine agonist, cabergoline, and a synthetic analogue of prostaglandin F2 alpha, cloprostenol or dinoprost, was used to induce termination of pregnancy 25 (+/- 2) days after the first mating. The study was done in six bitches. Cabergoline was administered at a dose of 5 micrograms/kg daily over a period of nine days and cloprostenol was injected subcutaneously at 1-2 micrograms/kg (dinoprost at a dose of 25 micrograms/kg) every other day. Treatment efficacy was 100%. No side effects were observed. Pregnancy and its termination was diagnosed by ultrasonographic examination. The combination of cabergoline and cloprostenol offers a simple and safe procedure for the termination of unwanted pregnancy.
authors.forename: P
authors.initials: P
authors.lastname: Hettling
mesh_terms: D000019:Abortifacient Agents / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods / Q000662:veterinary*; D000818:Animals; D000077465:Cabergoline; D003008:Cloprostenol / Q000008:administration & dosage*; D015237:Dinoprost / Q000008:administration & dosage*; D004285:Dogs; D018491:Dopamine Agonists / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004873:Ergolines / Q000008:administration & dosage*; D005260:Female; D007279:Injections, Subcutaneous; D011247:Pregnancy
chemical_list: D000019:Abortifacient Agents; D018491:Dopamine Agonists; D004873:Ergolines; D003008:Cloprostenol; D015237:Dinoprost; D000077465:Cabergoline
vernacular_title: Einsatz einer Kombinationsbehandlung eines synthetischen PGF2 alpha-Analogons und eines Dopaminagonisten zum Abbruch ungewollter Gravidität bei Hündinnen. Eine Studie an sechs Fällen.