Urinary growth hormone excretion in post-menarcheal adolescent girls with type 1 diabetes.
The aim of the present study was to compare measurements of urinary growth hormone (GH), serum insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP3) between two groups of post-menarcheal girls, 13-18 y of age, one comprising 64 type 1 diabetic patients and the other 64 healthy girls matched for age and stage of puberty. GH was determined on two occasions in nocturnal urine samples by using a modification of an immunoradiometric method for serum. Significantly higher urinary GH concentrations but lower IGF-I and IGFBP3 levels were found in diabetic girls than in controls (p < 0.001). A significant correlation was found between urinary GH concentrations and the daily dose of insulin (U kg[-1]) (r = 0.426, p = 0.003). Urinary GH concentrations were also significantly related to HbA1c (r = 0.380, p = 0.003). In conclusion, disturbances of the GH-IGF-I axis may be evaluated by the use of non-invasive urinary GH measurements, which is a simple alternative to frequent sampling of serum GH. Increased GH secretion seems to be related to a great need for insulin and poor metabolic control. More knowledge about underlying causal factors in the disturbed GH-IGF-I axis is required.
Aman
J
J
Department of Paediatrics, Orebro Medical Centre Hospital, Sweden.
Kroon
M
M
Jones
I
I
Segnestam
K
K
Snellman
K
K
D000293:Adolescent; D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000652:urine*; D019382:Human Growth Hormone / Q000652:urine*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000652:urine*; D007334:Insulin-Like Growth Factor I / Q000652:urine*; D008297:Male; D011627:Puberty; D011863:Radioimmunoassay; D012044:Regression Analysis; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I