[Evaluation of treatment with cyclosporine in three patients with pulmonary fibrosis].
There are few reports on the use of cyclosporine in idiopathic pulmonary fibrosis, in experimental animals or humans. We report three patients with advanced pulmonary fibrosis in whom steroid therapy failed and that received cyclosporine in a dose of 3 to 5 mg/kg for three to five months. One patient developed systemic hypertension that subsided reducing the dose of cyclosporine. No positive changes in dyspnea were obtained and pulmonary function tests deteriorated during the treatment period. We conclude that cyclosporine treatment had no clinical benefit in these patients with pulmonary fibrosis.
Undurraga
A
A
Servicio de Medicina INERyCT, Anatomía Patológica Hospital del Salvador, Facultad de Medicina, Universidad de Chile.
Meneses
M
M
Oyarzún
M
M
D000368:Aged; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000188:drug therapy* / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine
Evaluación del tratamiento con ciclosporina en tres pacientes con fibrosis pulmonar.