title: Preparation of silicone microspheres by emulsion polymerization: application to the encapsulation of a hydrophilic drug.
abstract: The objective of this work was to evaluate the ability of appropriate silicone elastomers to encapsulate hydrophilic compounds in microspheres prepared according to a multiphase emulsion-polymerization process. The particle size of the microspheres can be modified by controlling the usual emulsification parameters, such as the viscosity of the different phases, shear rates and surface activity properties of additives. The encapsulation efficiencies of a hydrophilic drug, propranolol hydrochloride, were very high but its release rates were very slow. Osmotic agents such as glycerol and propylene glycol did not enhance the release rate, whereas it was slightly increased by both sodium chloride addition and higher drug loading.
authors.affiliation: Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacie Galénique et Biopharmacie, Université de Nancy I, France.
authors.forename: F
authors.initials: F
authors.lastname: Kedzierewicz
authors.forename: X
authors.initials: X
authors.lastname: Darme
authors.forename: A
authors.initials: A
authors.lastname: Etienne
authors.forename: J
authors.initials: J
authors.lastname: Lemut
authors.forename: M
authors.initials: M
authors.lastname: Hoffman
authors.forename: P
authors.initials: P
authors.lastname: Maincent
mesh_terms: D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods*; D005990:Glycerol / Q000494:pharmacology; D008854:Microscopy, Electron; D008863:Microspheres; D011433:Propranolol / Q000493:pharmacokinetics*; D019946:Propylene Glycol / Q000494:pharmacology; D012828:Silicones / Q000737:chemistry*; D012965:Sodium Chloride / Q000494:pharmacology; D014783:Viscosity
chemical_list: D012828:Silicones; D012965:Sodium Chloride; D019946:Propylene Glycol; D011433:Propranolol; D005990:Glycerol