[Mechanisms of cell death in Alzheimer's disease].
Molecular mechanisms involved in neuronal degeneration in Alzheimer's disease remain still unknown. A toxic effect induced by beta amyloid, oxidative stress, excitotoxicity and alterations in signal transduction mechanisms are the main factors linked to neuronal death. In addition, it has been suggested that apoptosis may also participate as a part of the cascade of events resulting in neurodegeneration.
Luquin
M R
MR
Departamento de Neurología y Neurocirugía, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
Martínez-Vila
E
E
Saldise
L
L
D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D017209:Apoptosis; D016923:Cell Death / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009498:Neurotoxins / Q000009:adverse effects; D018377:Neurotransmitter Agents / Q000378:metabolism; D018384:Oxidative Stress; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D016229:Amyloid beta-Peptides; D009419:Nerve Tissue Proteins; D009498:Neurotoxins; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter; D019204:GTP-Binding Proteins
Mecanismos de muerte celular en la enfermedad de Alzheimer.