Helicases: a unifying structural theme?
The recent structure determinations of PcrA DNA helicase, NS3 RNA helicase, and Rep DNA helicase have revealed similarities between their folds. When these data are examined with sequence and biochemical analyses, as well as microscopy studies of hexameric helicases, a picture of a unifying structure and mechanism for all helicases is beginning to emerge.
Bird
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LE
Sir William Dunn School of Pathology, University of Oxford, UK.
Subramanya
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HS
Wigley
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DB
D004247:DNA / Q000378:metabolism; D004265:DNA Helicases / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D008958:Models, Molecular; D017510:Protein Folding; D013329:Structure-Activity Relationship
D004247:DNA; D004265:DNA Helicases