Metipranolol-associated nongranulomatous anterior uveitis.
OBJECTIVE
To describe the findings in a patient with a nongranulomatous anterior uveitis, presumed to be induced by metipranolol.


METHODS
A 69-year-old woman developed bilateral, nongranulomatous, anterior uveitis while undergoing treatment with metipranolol 0.3% for primary open-angle glaucoma. Four months after resolution of the initial episode, the patient was challenged with metipranolol 0.3% in the right eye.


RESULTS
On reinstituting metipranolol 0.3%, the patient once again developed a unilateral, nongranulomatous, anterior uveitis in the challenged eye.


CONCLUSIONS
Metipranolol 0.3% eyedrops, used to treat primary open-angle glaucoma, appear to cause a nongranulomatous anterior uveitis.
Patel
N P
NP
Glaucoma Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Patel
K H
KH
Moster
M R
MR
Spaeth
G L
GL
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006099:Granuloma / Q000139:chemically induced; D006801:Humans; D007429:Intraocular Pressure; D014290:Metipranolol / Q000009:adverse effects* / Q000627:therapeutic use; D009883:Ophthalmic Solutions; D012008:Recurrence; D014606:Uveitis, Anterior / Q000139:chemically induced*; D014792:Visual Acuity
D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions; D014290:Metipranolol