Experimental study of antidiarrheal activity of Salicairine.
Experimental antidiarrheal activity of a traditionally used medication, Salicairine, was demonstrated in comparison to loperamide by significant inhibition of castor oil-induced diarrhea in mice (increases in hard faeces/total faeces ratio of 38 and 54 and 5 and 54% with respect to controls, at 0.5 and 1 mL/kg and 1 and 2 mg/kg, respectively) and bisacodyl-induced increase in large intestine transit in rats (125 and 280 and 210% with respect to controls, at 0.4 and 2 mL/kg Salicairine and 5 mg/kg loperamide, respectively). Salicairine was able to reduce contractions of isolated rat duodenum induced by barium chloride and acetylcholine, although not completely (that is about 60%) as seen with loperamide. Also, it did not change normal gastrointestinal transit in mice at doses of 0.5 to 1 mL/kg, conversely to loperamide which had a significant effect (decrease of 50%) at 2 mg/kg. Finally, Salicairine at 0.01 mL/mL, like loperamide at 0.2 mg/mL, significantly increased net fluid absorption in rat colon, either in basal conditions (30 and 64% respectively) or after a prostaglandin E1-induced increase in net fluid secretion (41 and 35%, respectively). The antidiarrheal activity of Salicairine is possibly related, at least in part, to an increase in colon net fluid absorption or a decrease in net fluid secretion.
Brun
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Laboratoire de Physiologie et Pharmacologie-PCEBM, Faculté de Pharmacie, Université Joseph Fourier, La Tronche, France.
Wang
X P
XP
Willemot
J
J
Sevenet
T
T
Demenge
P
P
D000109:Acetylcholine / Q000494:pharmacology; D000527:Alprostadil / Q000494:pharmacology; D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D017609:Barium Compounds / Q000494:pharmacology; D001726:Bisacodyl / Q000633:toxicity; D001834:Body Water / Q000378:metabolism; D002368:Castor Oil / Q000633:toxicity; D002400:Cathartics / Q000633:toxicity; D002712:Chlorides / Q000494:pharmacology; D003106:Colon / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced / Q000503:physiopathology*; D004386:Duodenum / Q000187:drug effects; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D047348:Hydrolyzable Tannins; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects; D008139:Loperamide / Q000494:pharmacology; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013634:Tannins / Q000494:pharmacology*
D000930:Antidiarrheals; D017609:Barium Compounds; D002400:Cathartics; D002712:Chlorides; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; D013634:Tannins; C111726:salicairine; C024986:barium chloride; D001726:Bisacodyl; D008139:Loperamide; D002368:Castor Oil; D000527:Alprostadil; D000109:Acetylcholine