Synthesis and conformational analysis of two 2-oxopiperazine-containing tetrapeptide analogues.
One unsubstituted and one stereoselectively prepared 3-(S)-substituted-2-oxopiperazine have been used as dipeptide templates to generate tetrapeptide analogues. NMR analysis shows that these tetrapeptide analogues present an inverse gamma-turn conformation in chloroform.
Pohlmann
A
A
Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
Guillaume
D
D
Quirion
J C
JC
Husson
H P
HP
D000478:Alkylation; D002725:Chloroform; D004151:Dipeptides; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry*; D011487:Protein Conformation; D013698:Templates, Genetic
D004151:Dipeptides; D009842:Oligopeptides; D010879:Piperazines; D002725:Chloroform