Amide derivatives with H1-antihistaminic effect.
The synthesis and the structure-activity correlation of a series of N-aminoalkylacetamides as H1-antihistaminic agents have been carried out. The compounds were tested in vitro by measurement of the inhibition of histamine-induced contractions on isolated guinea pig ileum; the results are expressed as pA2.
Saturnino
C
C
Facoltà di Farmacia, Università degli Studi di Salerno, Penta-Salerno, Italy.
Saturnino
P
P
De Martino
G
G
Lancelot
J C
JC
Perrine
D
D
Boureau
R
R
Robba
M
M
D000577:Amides / Q000737:chemistry*; D000818:Animals; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D013329:Structure-Activity Relationship
D000577:Amides; D006634:Histamine H1 Antagonists; D006632:Histamine