[Apoptotic cell death of F9 mouse embryonal teratocarcinoma depends on cell population density].
Apoptosis, or programmed cell death, is an active process fundamental to the development and homeostasis of multicellular organisms. Mouse embryonal carcinoma F9 cell line was shown to express wild type p53 protein known to be one of the major regulators of apoptotic cell death. Herein we describe apoptosis-inducing conditions for F9 cells. The density reached by a cell population in culture is shown to be a factor of apoptotic death for both undifferentiated and induced to differentiation F9 cells. However, the relationships between population cell density and apoptosis induction are different in undifferentiated and differentiating cells.
Malashicheva
A B
AB
Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
Kisliakova
T V
TV
Pospelov
V A
VA
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002452:Cell Count; D002454:Cell Differentiation / Q000502:physiology; D006706:Homeostasis; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis; D018243:Teratocarcinoma / Q000473:pathology*; D014407:Tumor Cells, Cultured
D009363:Neoplasm Proteins
Apoptoticheskaia gibel' kletok émbrional'noĭ teratokartsinomy myshi F9 zavisit ot plotnosti kletochnoĭ populiatsii.