Effect of various marine lipids on transdermal drug delivery--in vitro evaluation.
The effects of several marine lipids on the penetration of hydrocortisone and nitroglycerin through excised hairless mouse skin have been studied. Fatty acid extracts obtained by hydrolysis of Portuguese dog-fish-liver-oil or by hydrolysis of cod-liver-oil were shown to be effective skin penetration enhancers. Phospholipid obtained from squid was also shown to be effective enhancer. However, the enhancing effect of the marine products could generally be associated with their content of free unsaturated fatty acids. The fatty acid extract obtained from cod-liver-oil caused insignificant skin irritation when incorporated into an ointment base and applied to human skin.
Loftsson
T
T
Department of Pharmacy, University of Iceland, Reykjavik.
Gunnarsdóttir
T
T
Magnúsdóttir
L M
LM
Frioriksdóttir
H
H
Guomundsdóttir
T K
TK
Olafsson
J H
JH
Haraldsson
G G
GG
Guomundsson
G
G
Hjaltason
B
B
D000279:Administration, Cutaneous; D000287:Administration, Topical; D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D005395:Fish Oils / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D006854:Hydrocortisone; D007509:Irritants / Q000633:toxicity; D051379:Mice; D008812:Mice, Hairless; D008875:Middle Aged; D009824:Ointments; D012869:Skin Absorption / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet
D000893:Anti-Inflammatory Agents; D005395:Fish Oils; D007509:Irritants; D009824:Ointments; D006854:Hydrocortisone