Evidence for an inhibition by endogenous galanin of neurogenic cutaneous vasodilatation in the pigeon.
The effect of high affinity galanin antagonist M35 on neurogenic cutaneous vasodilatation has been studied in the pigeon using a Laser Doppler Imager. Cutaneous application of mustard oil or antidromic electrical stimulation of a cutaneous nerve produced a small increase in skin blood flow. Close arterial injection of M35 prior to chemical or electrical stimulation resulted in a marked augmentation of the vasodilatory response. This effect was abolished by chronic denervation. The results suggest a nerve-mediated inhibitory effect of endogenous galanin on neurogenic cutaneous vasodilatation in the pigeon skin and provide the first experimental evidence for an inhibitory local regulatory function of cutaneous sensory nerves at least in the avian skin.
Sántha
P
P
Department of Physiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Pierau
F K
FK
Jancsó
G
G
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D010856:Columbidae; D003714:Denervation; D004558:Electric Stimulation; D019004:Galanin / Q000378:metabolism* / Q000494:pharmacology; D006145:Guanethidine / Q000494:pharmacology; D017078:Laser-Doppler Flowmetry; D009149:Mustard Plant; D009475:Neurons, Afferent / Q000502:physiology*; D010446:Peptide Fragments / Q000378:metabolism* / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D010938:Plant Oils; D012867:Skin / Q000098:blood supply* / Q000294:innervation*; D013268:Stimulation, Chemical; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D000959:Antihypertensive Agents; D010446:Peptide Fragments; D010936:Plant Extracts; D010938:Plant Oils; C074069:galanin-(1-13)-bradykinin-(2-9)-amide; D019004:Galanin; D001920:Bradykinin; C027793:mustard oil; D006145:Guanethidine