Influence of sphingolipids on T lymphocyte activation.
Sphingolipid metabolism in immune cells results in formation of a second lipid messenger, e.g., ceramide, sphingosine, ceramide-1-phosphate, and sphingosine-1-phosphate. They are involved in a common signaling which controls the main stages of the lymphocyte development, differentiation, activation, and proliferation in response to a mitogenic and antigenic stimuli, and to initiate programmed cell death. Both, the sphingomyelin cycle products and inhibitor of ceramide synthase--fumonisin B1--have been shown to affect the CD3, CD4, CD8, CD45, and other T lymphocyte surface antigen expression, to disrupt lymphocyte subpopulation balance, to inhibit DNA synthesis in normal lymphocytes, and to suppress an immune response to T-dependent antigens in vivo. The common targets of the TCR/CD3-derived and sphingolipid-mediated signaling pathways may provide the sphingolipid effect on immune cells.
Martinova
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EA
Institute of Nutrition, Russian Academy of Medical Sciences, Moscow, Russia.
D000818:Animals; D017252:CD3 Complex / Q000378:metabolism; D002454:Cell Differentiation; D006801:Humans; D008213:Lymphocyte Activation; D020929:Mitogen-Activated Protein Kinase Kinases; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015290:Second Messenger Systems; D015398:Signal Transduction; D013107:Sphingolipids / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell; D013107:Sphingolipids; D011494:Protein Kinases; D020929:Mitogen-Activated Protein Kinase Kinases