Exercise-induced oxidative stress in patients during thallium stress testing.
BACKGROUND
Free radical injury is implicated in the pathogenesis of coronary artery disease, including atherogenesis and reperfusion/injury. Strenuous physical exercise can cause oxidative stress by several mechanisms, including reperfusion/injury. We hypothesize that exercise-induced lipid peroxidation is greater among those with than those without exercise induced myocardial ischemia.


METHODS
The effect of physical exercise stress testing on plasma malonaldehyde (MDA) levels was compared between patients with (Group A, N = 8) and without (Group B) exercise-induced myocardial ischemia by thallium imaging.


METHODS
Two-way ANOVA was used to compare plasma MDA levels pre- and post-exercise, and paired t-test comparisons were conducted for percent MDA changes between Group A and Group B patients.


RESULTS
Two-way ANOVA revealed a significant (P = 0.002) directional difference in response to exercise between the groups' mean plasma MDA levels (Group A increased by 46 +/-12.7 percent, Group B decreased by 16.8+/-4.6 percent).


CONCLUSIONS
Differences in exercise-induced lipid peroxidation between patients with and without thallium documentation of myocardial ischemia have important implications in the development of clinical markers of coronary artery disease and further research related to atherogenesis.
Leaf
D A
DA
Division General Internal Medicine, West Los Angeles VAMC and UCLA School of Medicine, California 90073, USA.
Yusin
M
M
Gallik
D
D
Kleinman
M T
MT
D000368:Aged; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D013793:Thallium; D015899:Tomography, Emission-Computed, Single-Photon
D008315:Malondialdehyde; D013793:Thallium