Neonatal flumazenil therapy reverses maternal diazepam.
A woman at 32 weeks' gestation with eclampsia was given 120 mg diazepam shortly before emergency caesarean section. The infant had persistent apnoea and required respiratory support. Spontaneous respiration began after intravenous flumazenil infusion was started. Diazepam and its active metabolites were assayed during and after 5 d of treatment with flumazenil.
Dixon
J C
JC
Department of Neonatal Medicine, Southmead Hospital, Westbury-on-Trym, Bristol, UK.
Speidel
B D
BD
Dixon
J J
JJ
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D000931:Antidotes / Q000627:therapeutic use*; D001049:Apnea / Q000139:chemically induced* / Q000188:drug therapy; D002851:Chromatography, High Pressure Liquid; D003975:Diazepam / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D004461:Eclampsia / Q000188:drug therapy*; D004638:Emergency Treatment; D005260:Female; D005442:Flumazenil / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D000927:Anticonvulsants; D000931:Antidotes; D005442:Flumazenil; D003975:Diazepam