Dorsal root ganglion nerve cells transiently express increased immunoreactivity of the calcium-binding protein S-100beta after sciatic nerve transection.
Transiently increased immunoreactivity of the calcium binding protein S-100beta was demonstrated in spinal ganglion nerve cells after sciatic nerve transection. Neuropeptide Y (NPY), normally not seen in these nerve cells, appeared concomitantly. The transiently elevated co-expression of S-100beta and NPY is proposed to reflect an increased demand of neurotrophic and neuroprotective compounds in reactive neurons, tentatively regulating calcium ions.
Huang
Y L
YL
Institute of Anatomy and Cell Biology, University of Göteborg, S-413 90, Göteborg, Sweden. ying-lai.huang@anatcell.gu.se
Ding
M
M
Hansson
H A
HA
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000032:analysis / Q000096:biosynthesis*; D007839:Functional Laterality; D005727:Ganglia, Spinal / Q000378:metabolism*; D006706:Homeostasis; D007700:Kinetics; D008297:Male; D009414:Nerve Growth Factors; D009474:Neurons / Q000378:metabolism*; D009478:Neuropeptide Y / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis / Q000096:biosynthesis*; D012584:Sciatic Nerve / Q000502:physiology*
D002135:Calcium-Binding Proteins; D009414:Nerve Growth Factors; D009478:Neuropeptide Y; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D002118:Calcium