title: Diagnosis of personality disorders in cocaine-dependent individuals.
abstract: The authors explored the relationship between personality disorder (PD) and cocaine use. Diagnostic interviews for PD were performed at baseline and 12 weeks (study termination) in 47 cocaine-dependent individuals entering a pharmacologic treatment trial; 68% met criteria for a PD at baseline, 51% at study termination. In comparing baseline and termination PD, 22 individuals had no change in the number of PDs, 6 had more, and 17 had fewer. The group with an increase in the number of PD diagnoses had more positive urine drug screens than either of the other groups and more cocaine use by self-report. Personality disorders appear to be common in cocaine-dependent individuals but may be affected by cocaine use and withdrawal.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston 29425-0742, USA. sonnesc@musc.edu
authors.forename: S C
authors.initials: SC
authors.lastname: Sonne
authors.forename: K T
authors.initials: KT
authors.lastname: Brady
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D019970:Cocaine-Related Disorders / Q000150:complications / Q000523:psychology / Q000534:rehabilitation*; D016578:Crack Cocaine; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D011569:Psychiatric Status Rating Scales
chemical_list: D018712:Analgesics, Non-Narcotic; D016578:Crack Cocaine; D002220:Carbamazepine