title: [The current and future outlook in immunosuppressive therapy for children].
abstract: The various cell proportions that form the immune system intervene in the activation of autoreactive cells and in the occurrence of the associated inflammatory process. Advances of the study of the mechanism involved in the autoimmunity, and the development of new immunosuppressive agents used for transplantations have deeply modified the therapeutic approaches. The classic treatment of autoimmune diseases has relied on corticosteroids and immunosuppressive drugs. Now, these new treatments are evaluated on animal models, then controlled in clinical trials. Cyclosporin A has been shown to be effective in several autoimmune diseases. Intravenous immunoglobulins, cytokines, and anticytokines, immunotoxins, monoclonal anti-leukocyte antibodies (CD4, CD25) and soon peptide vaccination constitute the new types of treatments.
authors.affiliation: Clinica a II-a Pediatrie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: S
authors.initials: S
authors.lastname: Goţia
authors.forename: C
authors.initials: C
authors.lastname: Ionescu
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology; D002648:Child; D006801:Humans; D007108:Immune Tolerance; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007165:Immunosuppression Therapy / Q000379:methods / Q000639:trends*; D007166:Immunosuppressive Agents / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents
vernacular_title: Actualităţi şi perspective în terapia imunosupresivă la copil.