title: Normal ranges of renal physiological parameters for technetium-99m mercaptoacetyltriglycine and the influence of age and sex using a camera-based method.
abstract: 162 normal Chinese men and women underwent a 99mTc MAG3 renal study. Seventy-two males and 90 females were evaluated in 5 age groups: group 1, 61-80 years; group 2, 51-60 years; group 3, 41-50 years; group 4, 31-40 years, and group 5, 21-30 years. Each subject was required to fit the following criteria: (1) clinically no history of renal, urinary disorders and systemic diseases, normal blood pressure, kidney morphology, urinary examination and serum creatinine, and (2) for the gamma camera study normal hydration and renal images, and no pelvic, ureteric dilatation or retention of tracer should be found. The normal range of common physiological parameters for 99mTc MAG3 renal studies was measured in normal subjects. The effective renal plasma flow (ERPF, camera-based Schlegel method), percent function in each kidney (renal index, RI), time of peak renal parenchymal activity (Tmax) and half time of parenchymal activity following the peak (T1/2) were evaluated. The Tmax and T1/2 were determined with regions of interest over the entire kidney. The results showed that (1) between the sexes, there were no significant differences for any parameter; (2) between the age groups, the only significant difference was a decrease in ERPF, normalized for body surface area, with increasing age (group 1, 511.3 +/- 91.2; group 2, 559.5 +/- 102.1; group 3, 577.1 +/- 79.2; group 4, 607.8 +/- 101.1, and group 5, 610.2 +/- 109.2), and (3) the RI, Tmax and T1/2 were symmetrical and did not vary between the sexes or age groups (left vs. right: RI = 49.6 +/- 2.2 vs. 50.4 +/- 2.2%, Tmax = 3.63 +/- 1.13 vs. 3.75 +/- 1.11 min, and T1/2 = 5.38 +/- 1.65 vs. 5.83 +/- 1.88 min). We find that (1) ERPF for 99mTc MAG3 decreases with age in normal Chinese, which is similar to the results of Western countries, and (2) the RI, Tmax and T1/2 were symmetrical and did not vary between the sexes or age groups in normal Chinese, and are also similar to the results of Western countries.
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan. wylin@vghtc.vghtc.gov.tw
authors.forename: W Y
authors.initials: WY
authors.lastname: Lin
authors.forename: S P
authors.initials: SP
authors.lastname: Changlai
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012016:Reference Values; D017596:Renal Plasma Flow, Effective / Q000502:physiology*; D012737:Sex Factors; D013624:Taiwan; D017263:Technetium Tc 99m Mertiatide / Q000008:administration & dosage / Q000493:pharmacokinetics; D014741:Video Recording
chemical_list: D017263:Technetium Tc 99m Mertiatide