title: [Pharmacotherapy with benzodiazepines: basic principles and new developments].
abstract: Pharmacotherapy of various neurologic and psychiatric disorders is based on amplification of the effects of the inhibitory neurotransmitter GABA in the CNS. Of particular importance is the modulation of GABAA receptors by benzodiazepines. Their effects are activity-dependent and self limiting. With the development of new ligands for the benzodiazepine receptorsite selective activity-profiles with minimal side-effects are sought. Progress is to be expected from partial agonists and in particular from ligands with selectivity for receptor subtypes.
authors.affiliation: Institut für Pharmakologie, Universität und ETH Zürich.
authors.forename: H
authors.initials: H
authors.lastname: Möhler
mesh_terms: D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy*; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D009128:Muscle Spasticity / Q000188:drug therapy*; D011963:Receptors, GABA-A / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D011963:Receptors, GABA-A; D001569:Benzodiazepines
vernacular_title: Pharmakotherapie mit Benzodiazepinen: Grundlagen und neue Entwicklungen.