title: Effect of various marine lipids on transdermal drug delivery--in vitro evaluation.
abstract: The effects of several marine lipids on the penetration of hydrocortisone and nitroglycerin through excised hairless mouse skin have been studied. Fatty acid extracts obtained by hydrolysis of Portuguese dog-fish-liver-oil or by hydrolysis of cod-liver-oil were shown to be effective skin penetration enhancers. Phospholipid obtained from squid was also shown to be effective enhancer. However, the enhancing effect of the marine products could generally be associated with their content of free unsaturated fatty acids. The fatty acid extract obtained from cod-liver-oil caused insignificant skin irritation when incorporated into an ointment base and applied to human skin.
authors.affiliation: Department of Pharmacy, University of Iceland, Reykjavik.
authors.forename: T
authors.initials: T
authors.lastname: Loftsson
authors.forename: T
authors.initials: T
authors.lastname: Gunnarsdóttir
authors.forename: L M
authors.initials: LM
authors.lastname: Magnúsdóttir
authors.forename: H
authors.initials: H
authors.lastname: Frioriksdóttir
authors.forename: T K
authors.initials: TK
authors.lastname: Guomundsdóttir
authors.forename: J H
authors.initials: JH
authors.lastname: Olafsson
authors.forename: G G
authors.initials: GG
authors.lastname: Haraldsson
authors.forename: G
authors.initials: G
authors.lastname: Guomundsson
authors.forename: B
authors.initials: B
authors.lastname: Hjaltason
mesh_terms: D000279:Administration, Cutaneous; D000287:Administration, Topical; D000328:Adult; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D005395:Fish Oils / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D006854:Hydrocortisone; D007509:Irritants / Q000633:toxicity; D051379:Mice; D008812:Mice, Hairless; D008875:Middle Aged; D009824:Ointments; D012869:Skin Absorption / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000893:Anti-Inflammatory Agents; D005395:Fish Oils; D007509:Irritants; D009824:Ointments; D006854:Hydrocortisone