title: Human platelet antigen frequencies of platelet donors in the French population determined by polymerase chain reaction with sequence-specific primers.
abstract: To prevent human platelet alloimmunization, Blood Transfusion Centres have to develop a strategy close to the erythrocytes' one. The first step of this strategy is to perform the HPA typing of donors with an accurate method. We applied the PCR-SSP to type 800 platelet donors in the HPA-1 and HPA-5 systems and 350 in the HPA-2 and HPA-3 ones. This study reports the human platelet antigen frequencies of four platelet-specific alloantigen systems in the French population. The results are quite similar to those currently published for Caucasian population frequencies. Low prevalences are observed for the HPA-1b, (2%), HPA-2b (0.6%) and HPA-5b (2%) groups. Furthermore, this study confirms the need to type donors and recipients in the HPA-1 system at least, in case of post-transfusion pupura and platelet refractoriness to platelet transfusion therapy.
authors.forename: Y
authors.initials: Y
authors.lastname: Mérieux
authors.forename: M
authors.initials: M
authors.lastname: Debost
authors.forename: J
authors.initials: J
authors.lastname: Bernaud
authors.forename: A
authors.initials: A
authors.lastname: Raffin
authors.forename: F
authors.initials: F
authors.lastname: Meyer
authors.forename: D
authors.initials: D
authors.lastname: Rigal
mesh_terms: D016824:Antigens, Human Platelet / Q000235:genetics*; D001782:Blood Donors / Q000706:statistics & numerical data*; D017931:DNA Primers; D005007:Ethnology; D005602:France; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D010641:Phenotype; D016133:Polymerase Chain Reaction
chemical_list: D016824:Antigens, Human Platelet; D017931:DNA Primers