Cutaneous manifestations of relapsing polychondritis in a patient receiving goserelin for carcinoma of the prostate.
Relapsing polychondritis is a chronic rheumatologic disorder of unknown etiology. Cutaneous manifestations occur in nearly half of the patients and often precede cartilaginous involvement. We present the case of a man with a history of prostatic adenocarcinoma who underwent monthly injections of goserelin (Zoladex), an LH-RH analogue. Five months after the beginning of the treatment, he presented cutaneous manifestations, which then recurred monthly, after each goserelin injection. After goserelin interruption and replacement with another treatment (cyproterone acetate), the patient was asymptomatic for 2 months. A cutaneous relapse then occurred followed by a typical cartilaginous involvement. In our observation, goserelin seems to have triggered the cutaneous manifestations of relapsing polychondritis. An hormonal precipitating factor in relapsing polychondritis has already been suggested by reports of patients whose disease worsened under chorionic gonadotropin treatment or during pregnancy.
Labarthe
M P
MP
Department of Dermatology, Hopital Purpan Toulouse, France.
Bayle-Lebey
P
P
Bazex
J
J
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D002357:Cartilage Diseases / Q000209:etiology; D003534:Cyproterone / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology*; D004890:Erythema / Q000209:etiology*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives; D017273:Goserelin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011081:Polychondritis, Relapsing / Q000150:complications*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011693:Purpura / Q000209:etiology*; D012008:Recurrence
D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin; D007987:Gonadotropin-Releasing Hormone; D003534:Cyproterone