title: The clinical course of patients with suspected pulmonary embolism.
abstract: BACKGROUND
  The outcome of patients with suspected pulmonary embolism is known to a limited extent only.
  
  
  OBJECTIVE
  To address this limited knowledge in a cohort in whom pulmonary embolism was proved or ruled out.
  
  
  METHODS
  Consecutive patients with clinically suspected pulmonary embolism underwent lung scintigraphy and angiography if required. Pulmonary embolism was excluded by normal results of a lung scan or angiogram, and, if so, anticoagulant therapy was withheld. Pulmonary embolism was proved with a high-probability perfusion-ventilation lung scan or a confirmatory angiogram if a nondiagnostic lung scan was obtained. These patients were treated with heparin intravenously and anticoagulants orally on a long-term basis. All patients were followed up for 6 months, with a special focus on recurrent thromboembolism, bleeding complications, and mortality.
  
  
  RESULTS
  A total of 487 consecutive inpatients and outpatients were included. Pulmonary embolism was excluded or proved in 243 and 193 patients, respectively. In 51 patients a definite diagnosis could not be established. The overall prevalence of pulmonary embolism was 39%. In patients in whom pulmonary embolism was proved, excluded, or uncertain, recurrent venous thromboembolism was observed in 2.6%, 0.9%, and 2%, respectively. Serious bleeding complications occurred in 7 patients (3.3%; 95% confidence interval [CI], 1.8%-6.3%), 2 cases of which were fatal. The total mortality after 6 months in patients with proved or excluded pulmonary embolism was 17% (95% CI, 12%-23%) and 11% (95% CI, 7%-15%), respectively. Death was related to (recurrent) pulmonary embolism in 5% and 0% of these cases, respectively.
  
  
  CONCLUSIONS
  During a 6-month period, recurrent pulmonary embolism occurred in approximately 5 patients (2.5%) who were treated for a previous episode. Fatal bleeding complications attributable to the use of anticoagulants were encountered in 1%. The mortality among patients with suspected pulmonary embolism was considerable. However, most deaths were unrelated to pulmonary embolism, but were the result of serious underlying illnesses.
authors.affiliation: Center for Hemostasis, Thrombosis, Athersclerosis and Inflammation Research, Department of Radiology, Amsterdam, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: van Beek
authors.forename: P M
authors.initials: PM
authors.lastname: Kuijer
authors.forename: H R
authors.initials: HR
authors.lastname: Büller
authors.forename: D P
authors.initials: DP
authors.lastname: Brandjes
authors.forename: P M
authors.initials: PM
authors.lastname: Bossuyt
authors.forename: J W
authors.initials: JW
authors.lastname: ten Cate
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000150:complications / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology*; D016019:Survival Analysis; D014692:Ventilation-Perfusion Ratio