title: Adjunctive use of mitomycin C on endoscopic lacrimal surgery.
abstract: OBJECTIVE
  Endoscopic endonasal dacryocystorhinostomy (DCR) has some advantages over external DCR as a less invasive method with no skin incisions. But the success rate of the operation has not reached the level of external method. In this study, a wound healing inhibitor mitomycin C was used intraoperatively to prevent the closure of the osteum after the operation.
  
  
  METHODS
  Endoscopic endonasal DCR was performed on 40 eyes of 39 patients (26 female, 13 male). Mitomycin C was applied to the ostium in 14 of 23 patients who had undergone primary endoscopic DCR by means of a microdrill and in eight of 17 patients who had a revision endoscopic DCR secondary to a previously failed external DCR.
  
  
  RESULTS
  The postoperative follow up period was 9-27 (mean 18.2) months. The success rate of endoscopic DCR with intraoperative mitomycin C was 77.3%, whereas the success rate of endoscopic DCR without mitomycin C was 77.8%. The statistical analysis did not show a difference between the two groups according to the ostium size and their success rates.
  
  
  CONCLUSIONS
  Adjunctive use of a wound healing inhibitor is considered to increase the success rate of endoscopic endonasal DCR. Its intraoperative use seems to be easy and safe. But the study of this limited series shows no benefit in using it.
authors.affiliation: Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Zilelioğlu
authors.forename: S H
authors.initials: SH
authors.lastname: Uğurbaş
authors.forename: Y
authors.initials: Y
authors.lastname: Anadolu
authors.forename: M
authors.initials: M
authors.lastname: Akiner
authors.forename: T
authors.initials: T
authors.lastname: Aktürk
mesh_terms: D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007765:Lacrimal Apparatus / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D011184:Postoperative Period; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin