title: Neurotoxicodynamics of the interaction between ciprofloxacin and foscarnet in mice.
abstract: The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of gamma-aminobutyric acid (GABA)-GABA(A) receptor binding in the presence of PFA.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
authors.forename: M
authors.initials: M
authors.lastname: Ryu
authors.forename: A
authors.initials: A
authors.lastname: Nagata
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: J I
authors.initials: JI
authors.lastname: Kawakami
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Iga
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D000998:Antiviral Agents / Q000633:toxicity*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002939:Ciprofloxacin / Q000633:toxicity*; D004347:Drug Interactions; D017245:Foscarnet / Q000633:toxicity*; D008297:Male; D051379:Mice; D018079:Receptors, GABA / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced
chemical_list: D000890:Anti-Infective Agents; D000998:Antiviral Agents; D018079:Receptors, GABA; D017245:Foscarnet; D002939:Ciprofloxacin