Responsiveness of glycogen catabolism to adrenergic agonists during insulin-induced hypoglycemia in rat livers.
1. Insulin-induced hypoglycemia (IIH) promoted decreased responsiveness of hepatic glycogen catabolism to phenylephrine and isoproterenol, but not to glucagon and cyanide. 2. In addition, glycogen phosphorylase activity and glycogen levels were not affected by IIH. 3. It was concluded that hypoglycemia promoted changes in hepatic responsiveness to adrenergic agonists. 4. However, the ability of the liver to mobilize glycogen was not influenced by hypoglycemia.
Lopes
G
G
Department of Pharmacy and Pharmacology, University of Maringá, PR, Brazil.
Hell
N S
NS
Lima
F B
FB
Vardanega
M
M
Bazotte
R B
RB
D000322:Adrenergic Agonists / Q000494:pharmacology*; D000818:Animals; D019540:Area Under Curve; D003486:Cyanides / Q000494:pharmacology; D005765:Gastrointestinal Agents / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis*; D006019:Glycolysis / Q000187:drug effects*; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism*; D007328:Insulin / Q000009:adverse effects; D007545:Isoproterenol / Q000494:pharmacology; D019344:Lactic Acid / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000322:Adrenergic Agonists; D003486:Cyanides; D005765:Gastrointestinal Agents; D007328:Insulin; D010656:Phenylephrine; D019344:Lactic Acid; D006003:Glycogen; D005934:Glucagon; D005947:Glucose; D007545:Isoproterenol