title: Staphylococcus aureus exotoxin has limited and transient effects on cochlear electrophysiology.
abstract: Seven ears of Sprague-Dawley rats were exposed to 20 microliters Staphylococcus aureus exotoxin suspension by injection via the tympanic membrane into the round window niche. Another 6 ears were exposed to 20 microliters broth as controls. ABR was performed in the interval 2-31.5 kHz immediately before and 1, 2, 5, 7 and 10 days after the exposure. Although threshold changes could be found in the toxin-exposed group but not the control group in the frequency range 10-20 kHz, there were only statistically significant threshold changes--at 31.5 kHz--on the 1st, 2nd, 5th, and 7th days after the exotoxin injection. S. aureus exotoxin has minor transient but reversible effects on the inner ear, causing chiefly high-frequency threshold and latency changes.
authors.affiliation: Department of Oto-Rhino-Laryngology and Head and Neck Surgery, University Hospital, Uppsala, Sweden.
authors.forename: W J
authors.initials: WJ
authors.lastname: Hsu
authors.forename: M
authors.initials: M
authors.lastname: Anniko
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: M
authors.initials: M
authors.lastname: Lundholm
authors.forename: T S
authors.initials: TS
authors.lastname: Huang
mesh_terms: D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea / Q000502:physiology*; D004594:Electrophysiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005098:Exotoxins / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013211:Staphylococcus aureus
chemical_list: D005098:Exotoxins