title: Effect of repeated oral infection of hamsters with scrapie.
abstract: The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.
authors.affiliation: Robert Koch-Institut, Bundesinstitut für Infektionskrankheiten und nicht übertragbare Krankheiten, Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Diringer
authors.forename: J
authors.initials: J
authors.lastname: Roehmel
authors.forename: M
authors.initials: M
authors.lastname: Beekes
mesh_terms: D000284:Administration, Oral; D000818:Animals; D006224:Cricetinae; D004334:Drug Administration Schedule; D007267:Injections; D012608:Scrapie / Q000209:etiology* / Q000401:mortality