title: Naturally occurring 2'-O-methylpurine nucleosides with hypotensive properties.
abstract: 2'-O-Methylinosine (1) has been isolated for the first time and shown to be an intrinsic hypotensive principle. Its probable in vivo precursor, 2'-O-methyladenosine (3), showed stronger and even orally potent hypotensive activity. Resistance of the methyladenosine (3) against adenosine deaminase is thought to contribute to its long-lasting activity. The effect of both nucleosides (1 and 3) was not accompanied with any significant change in heart rate, which is often observed with adenosine.
authors.affiliation: Institute of Bio-Active Science, Nippon Zoki Pharm. Co. Ltd., Hyogo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Kageyama
authors.forename: Y
authors.initials: Y
authors.lastname: Joh
authors.forename: J
authors.initials: J
authors.lastname: Konishi
authors.forename: K
authors.initials: K
authors.lastname: Ienaga
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000243:Adenosine Deaminase / Q000378:metabolism; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D007249:Inflammation / Q000378:metabolism; D007288:Inosine / Q000031:analogs & derivatives / Q000494:pharmacology; D008750:Methyldopa / Q000494:pharmacology; D015394:Molecular Structure; D011684:Purine Nucleosides / Q000737:chemistry* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011918:Rats, Inbred SHR; D012867:Skin / Q000737:chemistry
chemical_list: D000959:Antihypertensive Agents; D011684:Purine Nucleosides; C024341:2'-O-methyladenosine; D008750:Methyldopa; D007288:Inosine; D000243:Adenosine Deaminase; D000241:Adenosine