title: The effects of voluntary running on cardiac mass and aortic compliance in Wistar-Kyoto and spontaneously hypertensive rats.
abstract: OBJECTIVE
  To investigate the effects of voluntary running exercise from 4-20 weeks of age on aortic compliance in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR).
  
  
  METHODS
  For each species we made comparisons between rats housed with an exercise wheel locked (10 rats) and unlocked (10 rats).
  
  
  METHODS
  Rats were killed using CO2 asphyxia and the aorta and heart of each rat were rapidly removed. The heart was dissected and weighed. A 4 mm descending proximal aortic ring was mounted on wires in an organ bath for determination of static compliance from the slope of the diameter-pressure relationship derived using Laplace's equation.
  
  
  RESULTS
  During the final 2 weeks of training WKY rats ran an average of 7.9 +/- 1.0 km/24 h compared with 1.0 +/- 0.2 km/24 h for SHR. Body weights of WKY rats and SHR and of animals housed with locked and unlocked exercise wheels did not differ. The septum, left ventricle and total heart weights and left ventricular:body weight ratios of sedentary SHR were greater than those of sedentary WKY rats. Trained WKY rats had significantly higher atrial, left and right ventricular and total heart weights and left ventricular:body weight ratios than did untrained WKY rats. Aortic compliance was higher in trained than it was in sedentary WKY rats (12.3 +/- 0.4 versus 14.2 +/- 0.5 microm/mmHg, P < 0.05). There was no difference between heart weights and aortic compliances of SHR housed with exercise wheels locked and unlocked.
  
  
  CONCLUSIONS
  Exercise-trained WKY rats had greater intrinsic aortic compliance when it was measured statically in vitro, which supports results of previous human work revealing a blood-pressure-independent component in the elevation of arterial compliance with training. The lower physical activity of the SHR strain used in this study could contribute to their higher blood pressures and lack of change in aortic compliance with exercise training.
authors.affiliation: Alfred and Baker Medical Unit, Baker Medical Research Institute, Prahran, Australia. kingwell@hotmail.com
authors.forename: B A
authors.initials: BA
authors.lastname: Kingwell
authors.forename: P J
authors.initials: PJ
authors.lastname: Arnold
authors.forename: G L
authors.initials: GL
authors.lastname: Jennings
authors.forename: A M
authors.initials: AM
authors.lastname: Dart
mesh_terms: D000818:Animals; D001011:Aorta / Q000033:anatomy & histology / Q000502:physiology*; D003187:Compliance; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology*; D009929:Organ Size; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY