[Cytokine pattern in various forms of sinusitis].
BACKGROUND
Inflammatory sinus diseases include acute sinusitis, chronic purulent sinusitis, and chronic polypoid rhinosinusitis. We investigated the cytokine profile of different types of rhinosinusitis in order to evaluate whether a distinct form of rhinosinusitis is associated with the expression of a specific cytokine profile.


METHODS
Fresh sinus mucosa obtained during routine surgery from patients with acute sinusitis (n = 10), chronic sinusitis (n = 7), antrochoanal polyp (n = 10), nasal polyps (n = 8), and controls of turbinate mucosa (n = 7) were homogenized. The cytokine protein content (IL-1 beta,IL-3,IL-5,IL-6,IL-8,GM-CSF) of tissue homogenates was measured using ELISA technique.


RESULTS
In the group of proinflammatory cytokines, the protein levels measured for interleukin IL-8, a proinflammatory cytokine, IL-1 beta, and IL-6 were elevated in acute sinusitis. In the group of eosinophil-activating cytokines interleukin-3, -5 and granulocyte an makrophage-colony stimulating factor, we measured a significantly elevated protein level of IL-5 in nasal polyp tissue in contrast to significantly elevated IL-3 protein level in chronic sinusitis.


CONCLUSIONS
These findings suggest that IL-8 plays a pivotal role in neutrophil-dominated and IL-5 in eosinophil-dominated sinusitis. IL-3 seems to sustain chronic inflammation.
Rudack
C
C
HNO-Klinik der Heinrich-Heine Universität Düsseldorf.
Hauser
U
U
Wagenmann
M
M
Bachert
C
C
Ganzer
U
U
D001706:Biopsy; D002908:Chronic Disease; D016207:Cytokines / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D009297:Nasal Mucosa / Q000276:immunology; D009298:Nasal Polyps / Q000175:diagnosis / Q000276:immunology; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000276:immunology; D012852:Sinusitis / Q000175:diagnosis / Q000276:immunology*
D016207:Cytokines; D018836:Inflammation Mediators
Zytokinmuster bei verschiedenen Formen der Nasennebenhöhlenentzündungen.