[The role of "growth" domain of urokinase in migration of smooth muscle cells].
The recombinant urokinase plasmogen activator (r-uPA) activated migration of the smooth muscle cells whereas the uPA mutant containing an altered growth factor-like domain (GFD) was ineffective. The uPA seems to possess properties of the urokinase receptor antagonist.
Stepanova
V V
VV
Research Cardiological Centre, Moscow, Russia.
Goncharova
E A
EA
Bibilashvili
R Sh
RSh
Tkachuk
V A
VA
D000818:Animals; D001011:Aorta / Q000166:cytology / Q000201:enzymology; D002478:Cells, Cultured; D002633:Chemotaxis; D004815:Epidermal Growth Factor / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000201:enzymology*; D009154:Mutation; D051381:Rats; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors / Q000378:metabolism; D055293:Receptors, Urokinase Plasminogen Activator; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics / Q000378:metabolism*
C524900:Plaur protein, rat; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D011994:Recombinant Proteins; D004815:Epidermal Growth Factor; D014568:Urokinase-Type Plasminogen Activator
Rol' "rostovogo" domena urokinazy v migratsii gladkomyshechnykch kletok.