title: Origin DNA-binding proteins.
abstract: The first step in DNA replication involves the recognition of origin DNA sequences by origin-binding proteins. The three-dimensional structures of three different origin DNA-binding proteins have recently been solved. These proteins form a structural class distinct from other DNA-binding proteins. One of the origin-binding proteins, Epstein-Barr virus nuclear antigen 1, most likely has two modes of DNA binding; the sequential use of these modes may be important for the initiation of DNA replication.
authors.affiliation: Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada. aled.edwards@utoronto.ca
authors.forename: A M
authors.initials: AM
authors.lastname: Edwards
authors.forename: A
authors.initials: A
authors.lastname: Bochkarev
authors.forename: L
authors.initials: L
authors.lastname: Frappier
mesh_terms: D000952:Antigens, Polyomavirus Transforming / Q000737:chemistry; D004261:DNA Replication; D004279:DNA, Viral / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D019281:Dimerization; D019309:Epstein-Barr Virus Nuclear Antigens / Q000737:chemistry* / Q000378:metabolism; D004854:Herpesvirus 4, Human; D008958:Models, Molecular; D011487:Protein Conformation; D018741:Replication Origin; D017385:Sequence Homology; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D000952:Antigens, Polyomavirus Transforming; D004279:DNA, Viral; D004268:DNA-Binding Proteins; C051550:E2 protein, Bovine papillomavirus; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins