title: Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate/carboxymethylcellulose gel.
abstract: OBJECTIVE
  To assess the efficacy of a bioabsorbable gel for reducing primary postoperative adhesions.
  
  
  METHODS
  A randomized, prospective, blinded study.
  
  
  METHODS
  Academic research environment.
  
  
  METHODS
  Forty-one New Zealand Rabbits.
  
  
  METHODS
  A chemically modified hyaluronate and carboxymethylcellulose (HA/CMC) gel formulation was applied to a bilateral uterine horn injury. Postoperative adhesions were assessed at a second-look laparoscopy.
  
  
  METHODS
  The uterine horn model was shown to be adhesiogenic, with 29 (70%) of 42 untreated uterine horns found to have adhesions. After gel treatment, 22 (55%) of 40 uterine horns were free of adhesions compared with 12 (30%) of 42 controls.
  
  
  RESULTS
  Animals treated with HA/CMC gel had significantly reduced postsurgical adhesion scores when compared with controls.
  
  
  CONCLUSIONS
  Treatment of injured uterine horn with HA/CMC gel resulted in a significant reduction in postoperative surgical adhesions.
authors.affiliation: Wayne State University, Detroit, Michigan, USA. rleach@cc.cms.wayne.educ
authors.forename: R E
authors.initials: RE
authors.lastname: Leach
authors.forename: J W
authors.initials: JW
authors.lastname: Burns
authors.forename: E J
authors.initials: EJ
authors.lastname: Dawe
authors.forename: M D
authors.initials: MD
authors.lastname: SmithBarbour
authors.forename: M P
authors.initials: MP
authors.lastname: Diamond
mesh_terms: D000818:Animals; D002266:Carboxymethylcellulose Sodium; D005260:Female; D005782:Gels; D006820:Hyaluronic Acid; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control*; D014591:Uterine Diseases / Q000517:prevention & control*; D014599:Uterus / Q000601:surgery
chemical_list: D005782:Gels; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium