title: Effect of metoprolol in reducing myocardial ischemic threshold during exercise and during daily activity.
abstract: In a study of 48 patients with coronary artery disease and evidence of ischemia during exercise and daily life, metoprolol reduced the threshold of myocardial ischemia in a dose-dependent manner. This effect of beta blockers is probably due to increased coronary tone.
authors.affiliation: Department of Cardiology, Shaare Zedek Medical Center, and Bikur Cholim Hospital, Jerusalem, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Tzivoni
authors.forename: A
authors.initials: A
authors.lastname: Medina
authors.forename: D
authors.initials: D
authors.lastname: David
authors.forename: Y
authors.initials: Y
authors.lastname: Barzilai
authors.forename: P
authors.initials: P
authors.lastname: Brunel
mesh_terms: D000203:Activities of Daily Living; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D001794:Blood Pressure; D004305:Dose-Response Relationship, Drug; D015716:Electrocardiography, Ambulatory; D015444:Exercise; D006339:Heart Rate; D006801:Humans; D008790:Metoprolol / Q000494:pharmacology*; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D000319:Adrenergic beta-Antagonists; D008790:Metoprolol