title: Novel lactone compounds from Mortierella verticillata that induce the human low density lipoprotein receptor gene: fermentation, isolation, structural elucidation and biological activities.
abstract: Among methods of controlling hypercholesterolemia and hyperlipidemia is the direct stimulation of hepatic low density lipoprotein (LDL) receptors. Two novel lactone compounds, CJ-12,950 and CJ-13,357, containing and unusual oxime moiety, were isolated from a zygomycete Mortierella verticillata. These lactones are potent inducers of the LDL receptor gene in vitro, that enhanced LDL receptor expression in human hepatocytes 2-fold at 100 nM.
authors.affiliation: Central Research Division, Pfizer Pharmaceuticals Inc., Aichi, Japan.
authors.forename: K A
authors.initials: KA
authors.lastname: Dekker
authors.forename: R J
authors.initials: RJ
authors.lastname: Aiello
authors.forename: H
authors.initials: H
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Inagaki
authors.forename: T
authors.initials: T
authors.lastname: Sakakibara
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: J F
authors.initials: JF
authors.lastname: Thompson
authors.forename: Y
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: N
authors.initials: N
authors.lastname: Kojima
mesh_terms: D018929:Cell Culture Techniques; D005285:Fermentation; D005786:Gene Expression Regulation; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009090:Mucorales / Q000737:chemistry* / Q000378:metabolism; D011973:Receptors, LDL / Q000235:genetics*
chemical_list: C111272:CJ-12950; C111273:CJ-13357; D007783:Lactones; D018942:Macrolides; D011973:Receptors, LDL