Investigation of infection in the neutropenic patient with fever.
Episodes of infection occurring in neutropenic patients are often associated with high levels of morbidity and mortality and prompt, accurate diagnosis allowing the rapid instigation of appropriate treatment can lead to an improved outcome. Recent developments in laboratory technology have increased the range of investigations available to the physician. The improved sensitivity of traditional microbiological culture, methods for antigen and antibody detection and the advances in molecular biology are among the reasons for an increased ability to detect both familiar and novel pathogens. This article describes the current methods available for determining the aetiology of an infectious episode in these patients. A plan of management for investigation of febrile episodes in neutropenic patients is suggested.
Gillespie
T
T
Department of Microbiology, Western General Hospital, Edinburgh, UK.
Masterton
R G
RG
D000209:Acute-Phase Proteins; D005335:Fever of Unknown Origin / Q000209:etiology*; D006801:Humans; D007239:Infections / Q000150:complications* / Q000175:diagnosis; D008828:Microbiological Techniques; D009503:Neutropenia / Q000150:complications*
D000209:Acute-Phase Proteins