Blood eosinophil and monocyte counts are related to smoking and lung function.
The aim of this study was to investigate the predictive value of peripheral eosinophil and monocyte blood counts regarding lung function in smokers and non-smokers, and to investigate the influence of smoking on these cell counts. Forced expiratory volume in 1 s (FEV1) measurements and blood samples were collected from 298 non-atopic smokers and 136 never-smokers. Blood samples were repeated in 160 smokers after cessation of smoking (quitters) and 30 continuing smokers, 2, 6, 12 and 26 weeks after smoking cessation. Monocyte (P < 0.05) but not eosinophil blood counts were higher in never-smokers compared to smokers. In never-smokers, blood eosinophil counts and monocyte counts correlated inversely (P < 0.05) and directly (P < 0.01), respectively, with standardized FEV1 residuals (FEVR). In smokers, blood eosinophil (P < 0.05) and monocyte (P < 0.05) counts correlated directly with FEVR independent of smoking history. After smoking cessation, monocyte blood counts (P < 0.05) increased. Both eosinophil and monocyte blood counts showed a greater increase in quitters with decreased lung function (P < 0.05). Former heavy smokers had higher blood eosinophil (P < 0.05) but lower monocyte (P < 0.05) count increase than had former light smokers. These data suggest that smoking influences eosinophil and monocyte blood counts and that this is associated with a small negative effect on lung function. Eosinophil blood counts had an opposite relation to lung function in smokers and non-smokers. Further research should include investigations of relations between smoking and stimulatory factors for recruitment and activity of eosinophils and monocytes.
Jensen
E J
EJ
Department of Respiratory Medicine, University Hospital, Aarhus, Denmark.
Pedersen
B
B
Narvestadt
E
E
Dahl
R
R
D000328:Adult; D003430:Cross-Sectional Studies; D004804:Eosinophils; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood / Q000503:physiopathology*; D016540:Smoking Cessation; D014797:Vital Capacity