Sensitization of Burkholderia cepacia to antibiotics by cationic drugs.
Chlorpromazine and prochlorperazine have previously been shown to enhance the susceptibility of Burkholderia cepacia to aminoglycosides. To screen other non-antibiotic drugs containing similar amine (-N-CH3) groups, we examined a range of such agents that are in current clinical use for the treatment of non-infectious diseases, in combination with antibiotics that are ineffective against B. cepacia. At a concentration of 0.2 mM, theobromine, theophylline, trifluoperazine, fluophenazine and coumarin-152 significantly reduced (by four-fold) the MICs of gentamicin and ceftazidime. Theobromine and theophylline also reduced the MICs of amikacin and azithromycin.
Rajyaguru
J M
JM
Department of Pediatric Infectious Diseases, Arnold Palmer Hospital for Children and Women, Orlando, FL 32806, USA. Jayshree@orhs.org
Muszynski
M J
MJ
D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D016956:Burkholderia cepacia / Q000187:drug effects*; D002412:Cations; D002442:Ceftazidime / Q000494:pharmacology; D003992:Dibucaine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D004359:Drug Therapy, Combination; D015738:Famotidine / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013805:Theobromine / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002412:Cations; D005839:Gentamicins; D015738:Famotidine; D017963:Azithromycin; D000583:Amikacin; D004155:Diphenhydramine; D008012:Lidocaine; D002442:Ceftazidime; D013806:Theophylline; D003992:Dibucaine; D013805:Theobromine