[Enalaprilat in the prevention of left ventricular hypertrophy induced by isoproterenol].
OBJECTIVE
To evaluate whether the enalaprilat, angiotensin I enzyme conversion inhibitor, could prevent the left ventricular hypertrophy (LVH) induced by isoproterenol.


METHODS
Seventy two adult Wistar-EPM rats were divided into four groups: CON, control; ENA, treated with enalaprilat (1 mg/kg via subcutaneous (s.c.) for 8 days); ISO, treated with isoproterenol (0.3 mg via s.c. for 8 days) e ENA + ISO, treated with both drugs simultaneously. Each group had the arterial blood pressure, cardiac rate and the left ventricle (LV) weight determined in 10 animals. In 8 animals from each group a small sample was taken from the LV and stained with hematoxyline-eosine and picrosirius for morphometric and ultra-structural studies with optic and transmission electronic microscopy.


RESULTS
The ISO group showed that the LV weight increased 47% in comparison with control. On the other hand the ENA + ISO group showed only 22.1% increase (p < or = 0.05). The morphometric and ultra-structural analyses revealed that isoproterenol induced cardiomyocite hypertrophy and augmented the content of the type I collagen in the cardiac interstitium.


CONCLUSIONS
Enalaprilat inhibited the isoproterenol action on the cardiomyocite, avoiding partially the LVH and decreasing the content of collagen fibers.
Costa
E A
EA
Escola Paulista de Medicina, UNIFESP, São Paulo.
Luna Filho
B
B
Póvoa
R
R
Ferreira Filho
C
C
Murad
N
N
Ferreira
M
M
Ferreira
C
C
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D015773:Enalaprilat / Q000627:therapeutic use*; D017379:Hypertrophy, Left Ventricular / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D007545:Isoproterenol / Q000009:adverse effects*; D008297:Male; D009206:Myocardium / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D000806:Angiotensin-Converting Enzyme Inhibitors; D015773:Enalaprilat; D007545:Isoproterenol
Enalaprilato na prevenção da hipertrofia ventricular esquerda induzida pelo isoproterenol.