Decreased energy demanding processes in the frontal lobes of schizophrenics due to neuroleptics? A 31P-magneto-resonance spectroscopic study.
In the present investigation on 31P-magneto-resonance spectroscopic parameters in the frontal lobe, we found phosphocreatine levels and the ratio phosphocreatine/adenosine triphosphate to be increased (12.62 +/- 1.98% resp. 0.31 +/- 0.06) in 50 neuroleptic-treated schizophrenics, whereas no differences were detected in 10 neuroleptic-free patients (11.66 +/- 2.57% resp. 0.29 +/- 0.08) compared to 36 controls (11.37 +/- 1.45 resp. 0.29 +/- 0.04). This result points to a major role of neuroleptics in the metabolism of high-energy phosphates.
Volz
H P
HP
Psychiatric Department, University of Jena, Germany.
Rzanny
R
R
Rössger
G
G
Hübner
G
G
Kreitschmann-Andermahr
I
I
Kaiser
W A
WA
Sauer
H
H
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010054:Brief Psychiatric Rating Scale; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010725:Phosphocreatine / Q000378:metabolism*; D010758:Phosphorus; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism*
D014150:Antipsychotic Agents; D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate