Induction of tumor necrosis factor-alpha mRNA in the kidney of the mouse chronic hepatitis model.
Previously we reported the induction of tumor necrosis factor (TNF)-alpha mRNA in the liver of interferon (IFN)-gamma transgenic mouse, which might be the result of IFN-gamma gene expression. In the present study, IFN-gamma mRNA was induced in the liver, kidney and lung. TNF-alpha mRNA was, however, induced in the liver and kidney, but not in the lung. Induction of interleukin (IL)-2 and IL-1beta mRNA was lacking in any of these organs. The present result showed the induction of TNF-alpha mRNA expression in the kidney of transgenic mouse.
Okamoto
T
T
Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama, Japan.
Furuya
M
M
Yamakawa
T
T
Yamamura
K
K
Hino
O
O
D000818:Animals; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D006521:Hepatitis, Chronic / Q000378:metabolism*; D007371:Interferon-gamma / Q000235:genetics; D007375:Interleukin-1 / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007375:Interleukin-1; D007376:Interleukin-2; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases