Nucleotide sequence of a highly conserved region of the canine p53 tumour suppressor gene.
An evolutionary conserved region of the canine tumour suppressor gene, p53, was PCR amplified and its DNA sequence determined. The 1003 bp fragment consisted of exons 5 to 8 and the intervening introns. A high level of sequence homology was demonstrated with human sequences, with the evolutionary conserved domains II, III, IV and V being identical.
Nasir
L
L
Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Scotland, U.K.
Argyle
D J
DJ
McFarlane
S T
ST
Reid
S W
SW
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004285:Dogs; D005091:Exons; D016158:Genes, p53; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid