Effectiveness of intermittent and continuous acoustic stimulation in preventing noise-induced hearing and hair cell loss.
Resistance to noise-induced hearing loss (NIHL) was studied in gerbils exposed either to intermittent or continuous low-level noise prior to an intense noise. Auditory-evoked brainstem response (ABR) thresholds, distortion product otoacoustic emissions (DPOAEs), Q10dB values from compound action potential (CAP) tuning curves, and outer hair cell (OHC) loss were measured for each group. Subjects were exposed to A-weighted noise (octave band noise centered at 2 kHz) on an intermittent (80 dB, 6 h/day) or continuous schedule (74 dB, 24 h/day) for 10 days, allowed to rest in quiet for 2 days, then exposed to intense A-weighted noise (107 dB, 24 h/day) for 2 days. A "noise-only" group was exposed only to the intense noise. Gerbils exposed in both the "intermittent" and "continuous" groups had less (15-30 dB) temporary threshold shift (TTS) than those in the noise-only group. In addition, the continuous group had less (10-15 dB) permanent threshold shift (PTS) than the other groups. These data suggest that resistance to NIHL is evident in both the intermittent and continuous groups when TTS is measured, but resistance to PTS is afforded only by the continuous paradigm. Both paradigms decreased OHC loss as compared to the noise-only group, with the continuous paradigm being most effective. However, neither paradigm conserved DPOAE amplitudes or tuning curve Q10dB values relative to the noise-only group.
White
D R
DR
Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston 29425-2242, USA.
Boettcher
F A
FA
Miles
L R
LR
Gratton
M A
MA
D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold; D016057:Evoked Potentials, Auditory, Brain Stem; D005849:Gerbillinae; D006198:Hair Cells, Auditory / Q000473:pathology*; D006317:Hearing Loss, Noise-Induced / Q000473:pathology* / Q000517:prevention & control*; D009622:Noise / Q000009:adverse effects; D013997:Time Factors