title: Cadmium uptake and bioaccumulation in Xenopus laevis embryos at different developmental stages.
abstract: The uptake of cadmium in Xenopus laevis embryos was studied by exposing them to solutions containing cadmium concentrations ranging from 0.1 to 2 mg Cd2+/L at seven developmental stages for 72 h. The uptake values were from 0.0027 microgram Cd2+/embryo (two blastomeres stage) to 0.081 microgram Cd2+/embryo, (hindlimb bud distinct stage). During early developmental stages, a limited permeability to cadmium could play a significant role for the survival of embryos. At the last developmental stage evaluated there was a significantly higher uptake of cadmium simultaneously with a very significant increase in the resistance against cadmium toxicity. The cadmium bioaccumulation factor (BF) ranged from 5 to 460. As a general pattern at all developmental stages the BF was higher in embryos exposed to the lower cadmium concentration, and as development advanced the BF increased.
authors.affiliation: Dipartimento di Biologia, Universita degli Studi di Padova, Trieste, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Herkovits
authors.forename: P
authors.initials: P
authors.lastname: Cardellini
authors.forename: C
authors.initials: C
authors.lastname: Pavanati
authors.forename: C S
authors.initials: CS
authors.lastname: Pérez-Coll
mesh_terms: D000818:Animals; D001757:Blastomeres / Q000187:drug effects / Q000378:metabolism; D002104:Cadmium / Q000493:pharmacokinetics* / Q000633:toxicity; D004625:Embryo, Nonmammalian / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D018878:Limb Buds / Q000187:drug effects / Q000378:metabolism; D015996:Survival Rate; D014018:Tissue Distribution; D014982:Xenopus laevis / Q000196:embryology* / Q000378:metabolism
chemical_list: D002104:Cadmium