Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea.
Four new triterpenoid compounds, 1-4, were isolated from the mycelium of a basidiomycete, Fomitella fraxinea, and their structures determined by spectroscopic analyses. Compounds 1-5 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with respective minimum inhibitory concentration (MIC) ranges of 35-75 and 90-130 microM.
Tanaka
N
N
Department of Applied Biological Science, Science University of Tokyo, Japan.
Kitamura
A
A
Mizushina
Y
Y
Sugawara
F
F
Sakaguchi
K
K
D000818:Animals; D001487:Basidiomycota / Q000187:drug effects / Q000201:enzymology*; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019384:Nucleic Acid Synthesis Inhibitors; D051381:Rats; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D019384:Nucleic Acid Synthesis Inhibitors; D014315:Triterpenes