Hyperemesis gravidarum associated with Helicobacter pylori seropositivity.
OBJECTIVE
To test the hypothesis that infection with Helicobacter pylori is associated with hyperemesis gravidarum.


METHODS
From January 1995 to November 1996 we enrolled 105 patients with hyperemesis gravidarum in a prospective study. The Helicobacter serum Immunoglobulin (Ig) G concentrations in these patients were compared with those in asymptomatic gravidas matched for week of gestation.


RESULTS
Positive serum IgG concentrations were found in 95 of the 105 hyperemesis patients (90.5%) compared with 60 of 129 controls (46.5%). A chi2 test showed statistical significance (P < .001). The mean (+/-standard deviation) index percentages of the IgG titers were 74.2+/-23.6% in the hyperemesis group and 24.3+/-4.4% in the control group (P < .01, Student t test).


CONCLUSIONS
Infection with H pylori may cause hyperemesis gravidarum.
Frigo
P
P
Department of Gynecology and Obstetrics, University Hospital of Vienna, Austria.
Lang
C
C
Reisenberger
K
K
Kölbl
H
H
Hirschl
A M
AM
D000293:Adolescent; D000328:Adult; D005260:Female; D015200:Fluoroimmunoassay; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis; D016480:Helicobacter pylori; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000150:complications* / Q000382:microbiology; D007074:Immunoglobulin G / Q000097:blood; D011247:Pregnancy; D011446:Prospective Studies; D012698:Serologic Tests
D007074:Immunoglobulin G