Lessons from TGF-beta transgenic mice.
Aberrant expression of TGF-beta and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-beta isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased activity of TGF-beta in the intact organism. We will review the pertinent features of some of these models, and discuss new insights provided by these studies into regulation and role of TGF-beta in health and disease.
Böttinger
E P
EP
Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY 10461-1602, USA. bottinge@aecom.yu.edu
Kopp
J B
JB
D000818:Animals; D004194:Disease; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D016296:Mutagenesis; D018125:Receptors, Transforming Growth Factor beta / Q000502:physiology; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000235:genetics* / Q000502:physiology*
D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta