title: Critical importance of in vivo amoxicillin and cefotaxime concentrations for synergy in treatment of experimental Enterococcus faecalis endocarditis.
abstract: The synergy between amoxicillin and cefotaxime against two strains of Enterococcus faecalis (JH2-2 and 6370) in vitro and in rabbit endocarditis was investigated. In vitro synergy was obtained only when amoxicillin concentrations were below the MBC and when cefotaxime concentrations were above 1 microg/ml. No synergy was observed in vivo, because of the short period of time during which these pharmacologic requirements were achieved.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 13, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Join-Lambert
authors.forename: J L
authors.initials: JL
authors.lastname: Mainardi
authors.forename: C
authors.initials: C
authors.lastname: Cuvelier
authors.forename: S
authors.initials: S
authors.lastname: Dautrey
authors.forename: R
authors.initials: R
authors.lastname: Farinotti
authors.forename: B
authors.initials: B
authors.lastname: Fantin
authors.forename: C
authors.initials: C
authors.lastname: Carbon
mesh_terms: D000658:Amoxicillin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D002439:Cefotaxime / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D013293:Enterococcus faecalis / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D011817:Rabbits
chemical_list: D000658:Amoxicillin; D002439:Cefotaxime