title: Auditory brainstem response, middle-latency response, and slow cortical potential in patients with partial epilepsy.
abstract: Auditory brainstem responses (ABRs), middle-latency responses (MLRs), and slow cortical potentials (SCPs) have been recorded in patients with partial epilepsy previously untreated by anticonvulsants. Peak latencies, interpeak intervals, and amplitudes were estimated and the mean group values were compared with the respective data in age- and gender-matched healthy individuals. Neither ABRs nor MLRs in the patients differed significantly from those in the control group. Conversely, the SCP characteristics demonstrated regular differences: the P2 peak latency in the patients was prolonged and both the P1N1 and N1P2 amplitudes were increased. Considering the mechanisms of the ABR and MLR, it has been suggested that the specific structures of central auditory pathway up to the primary cortex do not play any essential role in the pathogenesis of partial epilepsy. Furthermore, it is speculated that the SCP-generating cortical areas, being primarily of non-specific qualities, are intimately involved in the mechanisms of epilepsy.
authors.affiliation: Institute of Clinical and Experimental Neurology, Tbilisi, Georgia.
authors.forename: G
authors.initials: G
authors.lastname: Japaridze
authors.forename: D
authors.initials: D
authors.lastname: Kvernadze
authors.forename: T
authors.initials: T
authors.lastname: Geladze
authors.forename: Z
authors.initials: Z
authors.lastname: Kevanishvili
mesh_terms: D000293:Adolescent; D000328:Adult; D001933:Brain Stem / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography / Q000295:instrumentation; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation