title: Medication-induced gingival enlargement: a clinical review.
abstract: This review discusses the etiology and treatment of gingival hyperplasia. It cites evidence that medications such as phenytoin, an anticonvulsant; cyclosporine, an immunosuppressant; and numerous calcium channel blocking agents have been shown clinically and histologically to produce analogous gingival enlargements. A multiphasic approach to treating disfiguring gingival hyperplasia through mechanical and chemical plaque control, in conjunction with the surgical removal of the hyperplastic tissue, is discussed.
authors.affiliation: Department of Periodontics, Medical College of Georgia, Augusta, USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Silverstein
authors.forename: J J
authors.initials: JJ
authors.lastname: Garnick
authors.forename: M
authors.initials: M
authors.lastname: Szikman
authors.forename: B
authors.initials: B
authors.lastname: Singh
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D019214:Gingival Overgrowth / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents