Effect of cholera toxin on intestinal elimination of ciprofloxacin in rabbits.
The transepithelial intestinal elimination of ciprofloxacin (CPX) was studied in cholera toxin (CT)-challenged and control intestinal loops in the rabbit. CPX concentrations were similar in CT-challenged and control jejunal and ileal loops, while cecal elimination was negligible. The quantities of eliminated CPX per square centimeter of bowel wall were significantly higher in the small intestine CT-challenged loops. The mechanism of elimination of CPX in the small intestine is therefore mainly passive diffusion.
Musafija
A
A
Infectious Diseases Unit, Chaim Sheba Medical Center, Tel Aviv University School of Medicine, Tel Hashomer, Israel.
Barzilai
A
A
Ramon
J
J
Rubinstein
E
E
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D002432:Cecum / Q000187:drug effects / Q000378:metabolism; D002772:Cholera Toxin / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000378:metabolism / Q000493:pharmacokinetics*; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011817:Rabbits
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D002772:Cholera Toxin