Complications of craniofacial surgery for tumors involving the anterior cranial base.
OBJECTIVE
To evaluate the risk factors for postoperative complications among patients undergoing craniofacial resection for the treatment of anterior cranial base tumors, a retrospective analysis of patients treated in University of Tokyo Hospital between September 1987 and November 1996 was conducted.


METHODS
Twenty-nine patients underwent 33 craniofacial resections for tumors involving the anterior cranial base. Twenty-three of the 29 patients had malignant tumors and 6 patients had benign tumors. Anterior craniofacial resection was performed using a combination of intracranial and extracranial approaches. Radiotherapy and neoadjuvant chemotherapy were administrated to some patients.


RESULTS
Severe intracranial infections were more common among patients who underwent partial frontal lobectomies (P < 0.03). These infections occurred only in patients who had been treated previously with a craniotomy (P < 0.02) and a total radiation dose of > or =60 Gy (P = 0.06). Neither management of the extracranial structures nor methods of reconstruction of the cranial base showed significant correlation with major postoperative complications.


CONCLUSIONS
Compared with previous reports, craniofacial resection has become a relatively safe and effective procedure for the treatment of tumors involving the anterior cranial base. However, additional care should be taken with patients who have experienced a previous craniotomy, frontal lobe involvement, or radiotherapy with a total dose of > or =60 Gy.
Nibu
K
K
Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Tokyo, Japan.
Sasaki
T
T
Kawahara
N
N
Sugasawa
M
M
Nakatsuka
T
T
Yamada
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000453:epidemiology / Q000209:etiology; D003131:Combined Modality Therapy; D003399:Craniotomy; D004307:Dose-Response Relationship, Radiation; D005147:Facial Bones / Q000601:surgery*; D005260:Female; D005625:Frontal Lobe / Q000601:surgery; D006801:Humans; D015994:Incidence; D007239:Infections / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012086:Reoperation; D012189:Retrospective Studies; D012886:Skull / Q000601:surgery*; D019292:Skull Base Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D016019:Survival Analysis