In vitro antimycobacterial activity of 5-chloropyrazinamide.
5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.
Cynamon
M H
MH
Veterans Affairs Medical Center, Syracuse, New York 13210, USA. CYNAMON.MICHAEL@SYRACUSE.VA.GOV
Speirs
R J
RJ
Welch
J T
JT
D000995:Antitubercular Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009163:Mycobacterium bovis / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011718:Pyrazinamide / Q000031:analogs & derivatives* / Q000494:pharmacology*
C111084:5-chloropyrazinamide; C111083:5-chloropyrazinoic acid; D000995:Antitubercular Agents; D011718:Pyrazinamide