title: Reirradiation of brain and skull base tumors with fractionated stereotactic radiotherapy.
abstract: OBJECTIVE
  We evaluated the feasibility of fractionated stereotactic radiotherapy for small intracranial recurrences after conventional radiotherapy.
  
  
  METHODS
  Nineteen patients who had initially undergone conventional radiotherapy to intracranial lesions, receiving a median total dose of 50 Gy in 5 weeks, were retreated with stereotactic radiotherapy for their recurrences and received a median total dose of 42 Gy in seven fractions over 2.3 weeks.
  
  
  RESULTS
  Of the 19 patients, 15 achieved local control 3-51 months after reirradiation. No patient suffered from acute reaction, but one patient with a history of extensive radiotherapy developed progressive radionecrosis 9 months after reirradiation.
  
  
  CONCLUSIONS
  Fractionated stereotactic radiotherapy of intracranial recurrences appears to be effective in achieving in local control with negligible morbidity. We believe it merits further investigation in a prospective study.
authors.affiliation: Radiation Oncology Division, The National Cancer Center Hospital, Tokyo, Japan. ktokuue@gan2.ncc.go.jp
authors.forename: K
authors.initials: K
authors.lastname: Tokuuye
authors.forename: Y
authors.initials: Y
authors.lastname: Akine
authors.forename: M
authors.initials: M
authors.lastname: Sumi
authors.forename: Y
authors.initials: Y
authors.lastname: Kagami
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Oyama
authors.forename: Y
authors.initials: Y
authors.lastname: Inou
authors.forename: S
authors.initials: S
authors.lastname: Shibui
authors.forename: K
authors.initials: K
authors.lastname: Nomura
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D002648:Child; D005240:Feasibility Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000601:surgery*; D016634:Radiosurgery; D019292:Skull Base Neoplasms / Q000556:secondary / Q000601:surgery*