title: Effects of loxiglumide on pancreatic exocrine secretion stimulated by meal in conscious dogs.
abstract: The effects of loxiglumide (CAS 107097-80-3, CR 1505), a novel cholecystokinin-A(CCK-A) receptor antagonist, on pancreatic exocrine secretion stimulated by meal were examined in conscious dogs with chronic pancreatic fistula. Pancreatic exocrine secretion was stimulated by intraduodenal infusion of a liquid test meal and postprandial plasma CCK levels were apparently elevated. Loxiglumide inhibited the meal-stimulated outputs of pancreatic protein, amylase and bicarbonate at an intravenous dose of 10 mg/kg/h (p < 0.05). However, loxiglumide did not show apparent inhibition of pancreatic juice volume and trypsin output. These results show that the selective CCK-A antagonist loxiglumide may inhibit the increase of pancreatic exocrine secretion based on selective blockade of receptor binding of CCK endogenously induced by meal in dogs.
authors.affiliation: Pharmacological Research Laboratory, Tokyo Tanabe Co., Ltd., Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ninomiya
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Wakatsuki
authors.forename: M
authors.initials: M
authors.lastname: Saeki
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Edano
authors.forename: H
authors.initials: H
authors.lastname: Kasai
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Fujii
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D004285:Dogs; D005260:Female; D018565:Food-Drug Interactions; D006727:Hormone Antagonists / Q000097:blood / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism; D011377:Proglumide / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D014357:Trypsin / Q000378:metabolism
chemical_list: D001639:Bicarbonates; D006727:Hormone Antagonists; D011949:Receptors, Cholecystokinin; C053737:loxiglumide; D000681:Amylases; D014357:Trypsin; D011377:Proglumide