Effects of phencyclidine (PCP) and (+)MK-801 on sensorimotor gating in CD-1 mice.
1. Male CD-1 mice were tested for prepulse inhibition (PPI) following administration of PCP and the PCP site ligand, (+)MK-801, as well as the dopamine (DA) agonist (-)-apomorphine and DA releaser d-amphetamine. Similar to reports in rats, PCP (0.36-36.0 mumol/kg), (+)MK-801 (0.03-3.0 mumol/kg), (-)-apomorphine (3.3 and 10.0 mumol/kg) and d-amphetamine (3.0 and 8.0 mumol/kg) significantly reduced PPI when administered prior to testing. 2. Because PCP also binds to sigma receptors, the authors tested the sigma ligand (+)-3-PPP at (118 mumol/kg) which marginally increased the PPI. 3. Haloperidol (1.1 mumol/kg) pretreatment attenuated the reduction in PPI following (-)-apomorphine (10.0 mumol/kg), however no effects of haloperidol or clozapine pretreatment on (+)MK-801 disruption of PPI were observed. 4. Because of the pharmacological similarities between mouse data and previously published rat data, it is concluded that the mouse is a viable alternative to the rat for testing PPI.
Curzon
P
P
Neuroscience Department, Abbott Laboratories, Abbott Park, IL, USA.
Decker
M W
MW
D000161:Acoustic Stimulation; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010622:Phencyclidine / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D017480:Receptors, sigma / Q000187:drug effects / Q000502:physiology; D013216:Reflex, Startle / Q000187:drug effects*; D013045:Species Specificity
D018491:Dopamine Agonists; D010880:Piperidines; D017480:Receptors, sigma; D016291:Dizocilpine Maleate; C026539:preclamol; D010622:Phencyclidine; D003024:Clozapine; D006220:Haloperidol; D001058:Apomorphine; D003913:Dextroamphetamine