title: Type II DNA topoisomerases.
abstract: Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
authors.affiliation: Whitehead Institute, Cambridge, MA 02142, USA. berger@wi.mit.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Berger
mesh_terms: D019843:Archaeal Proteins; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D019843:Archaeal Proteins; D004247:DNA; C105141:DNA topoisomerase VI; D004250:DNA Topoisomerases, Type II