title: Air contamination with nitric oxide: effect on exhaled nitric oxide response.
abstract: This study examines the response of exhaled nitric oxide (NO) concentration (ECNO) and quantity of exhaled NO over time (EVNO) in 10 healthy subjects breathing into five polyethylene bags, one in which synthetic air was free of NO and four in which NO was diluted to concentrations of 20 +/- 0.6, 49 +/- 0.8, 98 +/- 2, and 148 +/- 2 ppb, respectively. Each subject was connected to each bag for 10 min at random. Minute ventilation and ECNO were measured continuously, and EVNO was calculated continuously. ECNO and EVNO values were significantly higher for an inhaled NO concentration of 20 ppb than for NO-free air. Above 20 ppb, ECNO and EVNO increased linearly with inhaled NO concentration. It is reasonable to assume that a share of the quantity of inspired NO over time (InspVNO) because of air contamination by pollution is rejected by the ventilatory pathway. Insofar as InspVNO does not affect endogenous production or the metabolic fate of NO in the airway, this share may be estimated as being approximately one third of InspVNO, the remainder being taken by the endogenous pathway. Thus, air contamination by the NO resulting from pollution greatly increases the NO response in exhaled air.
authors.affiliation: Faculté de Médecine de Grenoble, TIMC-PRETA CNRS UMR 5525, Laboratoire de Physiologie, La Tronche, France.
authors.forename: A
authors.initials: A
authors.lastname: Therminarias
authors.forename: P
authors.initials: P
authors.lastname: Flore
authors.forename: A
authors.initials: A
authors.lastname: Favre-Juvin
authors.forename: M F
authors.initials: MF
authors.lastname: Oddou
authors.forename: M
authors.initials: M
authors.lastname: Delaire
authors.forename: F
authors.initials: F
authors.lastname: Grimbert
mesh_terms: D000280:Administration, Inhalation; D000388:Air; D000393:Air Pollutants; D000704:Analysis of Variance; D002245:Carbon Dioxide / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D010101:Oxygen Consumption; D010366:Peak Expiratory Flow Rate; D011095:Polyethylenes; D011659:Pulmonary Gas Exchange; D012119:Respiration / Q000502:physiology*; D013147:Spirometry / Q000295:instrumentation; D013990:Tidal Volume; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D011095:Polyethylenes; D002245:Carbon Dioxide; D009569:Nitric Oxide