title: The fight of viruses against apoptosis.
abstract: The induction of apoptosis of virus-infected cells is an important host defense mechanism against invading pathogens. Some viruses express anti-apoptotic proteins that efficiently block apoptosis induced by death receptors or in response to stress signaled through mitochondria. Viral interference with host cell apoptosis leads to enhanced viral replication and may promote cancer.
authors.affiliation: Institute of Biochemistry, BIL Research Center, Epalinges, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Tschopp
authors.forename: M
authors.initials: M
authors.lastname: Thome
authors.forename: K
authors.initials: K
authors.lastname: Hofmann
authors.forename: E
authors.initials: E
authors.lastname: Meinl
mesh_terms: D000818:Animals; D017209:Apoptosis; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D002352:Carrier Proteins / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008928:Mitochondria / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D018406:Virus Physiological Phenomena
chemical_list: D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; C506386:CFLAR protein, human; D002352:Carrier Proteins; D015853:Cysteine Proteinase Inhibitors; D047908:Intracellular Signaling Peptides and Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D014764:Viral Proteins