title: In vitro susceptibility of Staphylococcus aureus isolated from blood to currently used antistaphylococcal drugs.
abstract: Changes in antibiotic susceptibility was evaluated in 77 consecutive nosocomial clinical isolates of Staphylococcus aureus collected from 1986 to 1994 at the Umberto I Polyclinic of the University of Rome (63 isolates) and from 7 other Roman hospitals (14 isolates). Oxacillin resistance in these isolates increased from 39% during the 1980s to 69% during the 1990s. Significant increases in resistance to ciprofloxacin, clindamycin and rifampicin were observed among oxacillin-resistant strains. No resistance to glycopeptides was observed although both teicoplanin and vancomycin had slightly reduced antistaphylococcal activity.
authors.affiliation: Department of Clinical Medicine, University of Rome La Sapienza, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Baiocchi
authors.forename: M
authors.initials: M
authors.lastname: Galiè
authors.forename: C
authors.initials: C
authors.lastname: Santini
authors.forename: P
authors.initials: P
authors.lastname: Carfagna
authors.forename: M
authors.initials: M
authors.lastname: Cassone
authors.forename: D
authors.initials: D
authors.lastname: Tarasi
authors.forename: M
authors.initials: M
authors.lastname: Venditti
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006020:Glycopeptides; D006801:Humans; D007558:Italy; D010068:Oxacillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D015610:Serum Bactericidal Test; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000904:Antibiotics, Antitubercular; D006020:Glycopeptides; D010406:Penicillins; D002981:Clindamycin; D002939:Ciprofloxacin; D010068:Oxacillin; D012293:Rifampin