Central nervous system endothelium in neuroinflammatory, neuroinfectious, and neurodegenerative disease.
Accumulating evidence points toward a significant role for the microvascular endothelium in the pathogenesis of several neurologic conditions. This review highlights those biochemical, anatomical, and physiological features of the endothelium thought to be dysfunctional in these disease states, and elaborates on novel treatment modalities that target the endothelium.
Andjelkovic
A V
AV
Department of Pharmacology, University of Connecticut Health Center, Farmington 06030, USA.
Pachter
J S
JS
D000818:Animals; D001424:Bacterial Infections / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008833:Microcirculation / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000503:physiopathology*; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D014777:Virus Diseases / Q000503:physiopathology*