Acute stroke in a young female with anti-human beta2-glycoprotein I antibodies.
We report the case of a woman who, at the age of 27, developed a cerebral arterial occlusion. The laboratory investigations showed an anti-human beta2-glycoprotein I antibody, but no other biological sign of antiphospholipid antibody syndrome or autoimmune disorders. The patient otherwise presented with diabetes and moderate obesity. The species specificity of anti-beta2-glycoprotein I antibodies probably explains the discrepancy between false negative results for antiphospholipid antibodies assayed by clotting and ELISA studies and positivity for anti-human beta2-glycoprotein I. Further studies will be important to evaluate the frequency of such antibodies, as well as their value as a risk factor for venous and arterial thrombosis, and their signification within the antiphospholipid antibody syndrome.
Guérin
V
V
Laboratoire d'Hémostase, Hopital Pellegrin-Tripode, Bordeaux, France.
Parrens
E
E
Couchouron
A
A
Freyburger
G
G
Baquey
A
A
Boisseau
M
M
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002544:Cerebral Infarction / Q000150:complications / Q000276:immunology*; D048909:Diabetes Complications; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000150:complications / Q000276:immunology*; D053482:beta 2-Glycoprotein I
D001323:Autoantibodies; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I