title: SKF 38393 enhances odor detection performance.
abstract: The purpose of this study was to determine the influence of the D1-selective partial agonist SKF 38393 on the odor detection performance of rats using high precision olfactometry and a go/no-go operant task. Previous studies have found that the D2 receptor partial agonist quinpirole decreases such performance, but the influences of D1 receptor activation are unknown. In experiment 1, such detection performance to the odorant ethyl acetate was enhanced by SKF 38393, relative to saline, in male rats at 7.5 and 10.0 mg/kg i.p. dose levels, but not at the lower doses of 1.0, 2.5, and 5.0 mg/kg. In experiment 2, this enhancement was replicated at the 7.5 and 10.0 mg/kg doses and was shown to occur at the 12.5 mg/kg dose as well. In experiment 3, similar enhancement was shown for the odorant eugenol in female rats at the 7.5, 10.0 and 12.5 mg/kg doses, suggesting this effect is neither sex-specific nor confined to the odorant ethyl acetate. In experiment 4, a 0.025 mg/kg dose of the D1 receptor antagonist SCH 23390 depressed the enhancement produced to ethyl acetate by 7.5 mg/kg SKF 38393 to control levels. Overall, these data demonstrate that, in contrast to quinpirole, SKF 38393 improves odor detection performance in the rat and that this phenomenon can be attenuated by the D1 receptor blocker SCH 23390.
authors.affiliation: Smell and Taste Center, Hospital of the University of Pennsylvania, and Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Philadelphia 19104, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Doty
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Bagla
authors.forename: W
authors.initials: W
authors.lastname: Huang
authors.forename: C
authors.initials: C
authors.lastname: Pfeiffer
authors.forename: G M
authors.initials: GM
authors.lastname: Brosvic
authors.forename: J M
authors.initials: JM
authors.lastname: Risser
mesh_terms: D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000523:psychology; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D009812:Odorants; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D012903:Smell / Q000187:drug effects*
chemical_list: D001552:Benzazepines; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine