Alterations in lipid composition and neuronal injury in primates following chronic aluminium exposure.
The effect of chronic aluminium exposure (25 mg/kg b.wt.) was studied on the lipid composition and various membrane-bound enzymes in different regions of monkey brain. Aluminium (Al) administration caused a significant decrease in the total lipid, glycolipid, and phospholipid content of primate brain. Cholesterol levels and the phospholipid to cholesterol ratio were, however, markedly increased as a consequence of Al administration, thereby indicating a loss of membrane integrity. This was further confirmed when Al treatment was found to have a significant effect on the various membrane-bound enzymes in terms of decreased activities of Na+ K+ ATPase and acetylcholinesterase, along with a decrease in the activity of the myelin-specific enzyme, 2' 3'-cyclic nucleotide phosphohydrolase.
Sarin
S
S
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Gupta
V
V
Gill
K D
KD
D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism
D000535:Aluminum