title: Characterization of the human gene coding for the swelling-dependent chloride channel ICln at position 11q13.5-14.1 (CLNS1A) and further characterization of the chromosome 6 (CLNS1B) localization.
abstract: Expression cloning revealed a chloride channel (ICln) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human ICln-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.
authors.affiliation: Department of Physiology, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020, Innsbruck, Austria.
authors.forename: U O
authors.initials: UO
authors.lastname: Nagl
authors.forename: M
authors.initials: M
authors.lastname: Erdel
authors.forename: F
authors.initials: F
authors.lastname: Bergmann
authors.forename: B
authors.initials: B
authors.lastname: Oehl
authors.forename: E
authors.initials: E
authors.lastname: Scandella
authors.forename: L
authors.initials: L
authors.lastname: Musante
authors.forename: L J
authors.initials: LJ
authors.lastname: Galietta
authors.forename: M
authors.initials: M
authors.lastname: Gschwentner
authors.forename: J
authors.initials: J
authors.lastname: Fürst
authors.forename: A
authors.initials: A
authors.lastname: Schmarda
authors.forename: S
authors.initials: S
authors.lastname: Hofer
authors.forename: G
authors.initials: G
authors.lastname: Utermann
authors.forename: P
authors.initials: P
authors.lastname: Deetjen
authors.forename: M
authors.initials: M
authors.lastname: Paulmichl
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D018118:Chloride Channels / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002896:Chromosomes, Human, Pair 6; D017931:DNA Primers; D005091:Exons; D015698:Genomic Library; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D007473:Ion Channels; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
chemical_list: C410035:CLNS1A protein, human; D018118:Chloride Channels; D017931:DNA Primers; D007473:Ion Channels