title: [Kinetics of development of human melanoma xenografts in immunosuppressed animals].
abstract: An experimental model of development of the human tumor xenografts (melanomas HCMB and Bro) in immunosuppressed phenotypically normal animals (CBA/Ca mice) was developed. Optimal conditions were established for immunodeficiency induction in the animals. Kinetics of development of the xenografts in the immunosuppressed animals was studied. The level of 0(6)-alkyl-guanine-DNA-alkyltransferase, an enzyme responsible for repair of DNA damage in the tumor cells induced by chemotherapeutic agents (nitroalkylurea), was determined.
authors.affiliation: Emanuel' Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Ostrovskaia
authors.forename: N M
authors.initials: NM
authors.lastname: Ul'ianova
authors.forename: M M
authors.initials: MM
authors.lastname: Fomina
authors.forename: V A
authors.initials: VA
authors.lastname: Rykova
authors.forename: A A
authors.initials: AA
authors.lastname: Konradov
authors.forename: E F
authors.initials: EF
authors.lastname: Brin
authors.forename: N V
authors.initials: NV
authors.lastname: Gorbunova
authors.forename: L B
authors.initials: LB
authors.lastname: Gorbacheva
authors.forename: D V
authors.initials: DV
authors.lastname: Khaleev
mesh_terms: D000818:Animals; D002279:Carcinoma 256, Walker / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D018827:Carcinoma, Lewis Lung / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007700:Kinetics; D008546:Melanoma, Experimental / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000378:metabolism; D014183:Transplantation, Heterologous / Q000276:immunology / Q000473:pathology*
chemical_list: D019853:O(6)-Methylguanine-DNA Methyltransferase
vernacular_title: Kinetika razvitiia ksenograftov melanom cheloveka na immunosupressirovannykh zhivotnykh.