Platelet activation in patients with sickle cell disease.
Vascular occlusion and vasculopathy underlie much of the morbidity in patients with sickle cell anaemia. Platelets may play a role in this vasculopathy. Samples from 43 patients with sickle cell disease (SCD) were examined for evidence of platelet activation using fluorescent-labelled monoclonal antibodies and flow cytometry. There was increased expression of activation-dependent antigens on the platelets from patients with SCD compared to those from both Caucasian and African-American controls. In addition, SCD patients had increased levels of platelet microparticles. Platelets are activated in patients with sickle cell disease. The contribution of platelet activation to sickle cell pathophysiology is under active investigation in our laboratories.
Wun
T
T
Division of Hematology and Oncology, UC Davis School of Medicine, Sacramento Medical Foundation Center for Blood Research, California 95817, USA.
Paglieroni
T
T
Rangaswami
A
A
Franklin
P H
PH
Welborn
J
J
Cheung
A
A
Tablin
F
F
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood*; D016824:Antigens, Human Platelet / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003251:Constriction, Pathologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000209:etiology; D015539:Platelet Activation; D010976:Platelet Count
D016824:Antigens, Human Platelet