Assessing the relationship between maternal cocaine use and abruptio placentae.
Abruptio placentae during pregnancy can result in significant morbidity and mortality to both mother and infant. A comprehensive literature search of publications from 1966 to April 1995 identified 11 studies on the association between maternal cocaine use and abruptio placentae. Their results were combined in a meta-analysis. The pooled odds ratio for abruptio placentae and maternal cocaine use was 3.92 (95% confidence interval 2.77-5.46). The strength and consistency of the association, its biological plausibility and the results of experimental studies in animals all suggest that cocaine use during pregnancy causes abruptio placentae.
Hulse
G K
GK
Faculty of Medicine and Dentistry, University of Western Australia, Australia. ghulse@uniwa.uwa.edu.au
Milne
E
E
English
D R
DR
Holman
C D
CD
D000037:Abruptio Placentae / Q000139:chemically induced*; D003042:Cocaine; D005260:Female; D006801:Humans; D011247:Pregnancy; D019966:Substance-Related Disorders / Q000150:complications*
D003042:Cocaine