title: Amonafide in patients with leiomyosarcoma of the uterus: a phase II Gynecologic Oncology Group study.
abstract: Twenty-six evaluable patients who had leiomyosarcoma of the uterus were treated with amonafide, 300 mg/m2, for 5 consecutive days every 3 weeks. One partial response (4%) resulted. Hematologic toxicity was substantial, with grade 3 or 4 events occurring as follows: leukopenia, 12 patients (46%); thrombocytopenia, 4 patients (15%); and granulocytopenia, 7 patients (27%). One patient had transient grade 4 renal failure. Considering the poor activity and substantial toxicity that was observed, no further studies are planned by the Gynecologic Oncology Group using amonafide at this dose schedule in leiomyosarcomas.
authors.affiliation: University of Rochester School of Medicine, New York, USA.
authors.forename: R
authors.initials: R
authors.lastname: Asbury
authors.forename: J A
authors.initials: JA
authors.lastname: Blessing
authors.forename: R
authors.initials: R
authors.lastname: Buller
authors.forename: J H
authors.initials: JH
authors.lastname: Malfetano
authors.forename: J
authors.initials: J
authors.lastname: Walker
authors.forename: B U
authors.initials: BU
authors.lastname: Sevin
mesh_terms: D000225:Adenine; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007094:Imides / Q000009:adverse effects / Q000627:therapeutic use*; D007546:Isoquinolines / Q000009:adverse effects / Q000627:therapeutic use*; D007890:Leiomyosarcoma / Q000188:drug therapy*; D008875:Middle Aged; D053644:Naphthalimides; D063065:Organophosphonates; D014594:Uterine Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D007094:Imides; D007546:Isoquinolines; D053644:Naphthalimides; D063065:Organophosphonates; C037020:amonafide; D000225:Adenine