Plasminogen/plasminogen activator and growth factor activation.
The plasminogen/plasminogen activator system is widely used in extracellular proteolysis. In this review the involvement of this system in tumour invasion, cell migration, growth factor presentation and inhibition of angiogenesis are discussed.
Rifkin
D B
DB
Department of Cell Biology, New York University Medical Center, NY 10016, USA.
Gleizes
P E
PE
Harpel
J
J
Nunes
I
I
Munger
J
J
Mazzieri
R
R
Noguera
I
I
D000818:Animals; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D009361:Neoplasm Invasiveness; D010958:Plasminogen / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D013268:Stimulation, Chemical; D016212:Transforming Growth Factor beta / Q000096:biosynthesis
D006133:Growth Substances; D011506:Proteins; D016212:Transforming Growth Factor beta; D010958:Plasminogen; D010960:Plasminogen Activators