In vitro antiviral activity on dengue virus of marine natural products.
Metabolites isolated from marine invertebrates, callipeltin A, crambescidin, ptilomycalin A, celeromycalin, gymnochrome B, gymnochrome D and isogymnochrome D previously shown bioactive on either herpes simplex virus 1 or human immunodeficiency virus, were tested on a new in vitro bioassay using the dengue virus 1. Only gymnochrome D and isogymnochrome D isolated from the living fossil crinoid Gymnocrinus richeri are highly potent dengue antiviral agents.
Laille
M
M
Institut Pasteur, Noumea (New Caledonia). laille@pasteur.nc
Gerald
F
F
Debitus
C
C
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry*; D002478:Cells, Cultured; D003715:Dengue / Q000188:drug therapy*; D003716:Dengue Virus / Q000187:drug effects*; D004447:Echinodermata / Q000737:chemistry*; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D010948:Viral Plaque Assay
D000998:Antiviral Agents