title: [Incidence of facial clefts in the Magdeburg region].
abstract: There is a varying frequency of oral clefts between different ethnic groups and several European regions: however, global investigations on the incidence of oral clefts over longer periods in Germany do not exist, because there has been no continuous system of registering malformations. Such a registration system has been in existence in Magdeburg, with a population of about 1.5 million and a yearly birth rate of about 8000 children, since 1980. A very high rate of oral clefts was found in Magdeburg, mainly a cleft lip with or without a cleft palate, which is a prevalence of 18.5 per 10,000 births. Twenty-two percent of all children with oral clefts had additional malformations. At a rate of about 10%, heart defects were most frequently combined with oral clefts. A significant prevalence increase was recorded in 1988 and 1989. Exogenous influences are being considered as a joint cause for this increase because of the prevalence peaks of neural tube defects from 1987 to 1989.
authors.affiliation: Monitoring-Zentrum zur Erfassung von Fehlbildungen, Universitätsklinikum Magdeburg.
authors.forename: C
authors.initials: C
authors.lastname: Rösche
authors.forename: V
authors.initials: V
authors.lastname: Steinbicker
authors.forename: I
authors.initials: I
authors.lastname: Röse
mesh_terms: D000015:Abnormalities, Multiple / Q000453:epidemiology; D002971:Cleft Lip / Q000453:epidemiology*; D002972:Cleft Palate / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D012737:Sex Factors
vernacular_title: Häufigkeit oraler Spaltbildungen in der Region Magdeburg.