[Pathogenesis of Alzheimer's disease].
Alzheimer's disease (AD) is a multifactorial entity with a complex pathogeny. Recent findings on this subject are discussed in this article, centering mainly on genetic factors, cerebral ischemia and their association with the most typical histologic lesions in AD. Finally, a hypothetical model is proposed, in which beta-amyloid represents the key element.
Alegre
M
M
Departamento de Neurología, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
Noé
E
E
Luquin
M R
MR
D000544:Alzheimer Disease / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism; D017209:Apoptosis; D002545:Brain Ischemia / Q000150:complications; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016874:Neurofibrillary Tangles; D010766:Phosphorylation; D053764:Presenilin-1; D053766:Presenilin-2; D011499:Protein Processing, Post-Translational; D016875:tau Proteins / Q000378:metabolism
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D008563:Membrane Lipids; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D016875:tau Proteins
Patogenia de la enfermedad de Alzheimer.