Monitoring of cerebral hemodynamics using near-infrared spectroscopy during local intraarterial thrombolysis: case report.
BACKGROUND
The efficacy of continuous measuring of changes in regional cerebrovascular hemoglobin saturation during local intraarterial thrombolytic therapy for middle cerebral artery (MCA) occlusion is discussed.


METHODS
To obtain real-time data on changing cerebral hemodynamics, near-infrared spectroscopy (NIRS) was used during recanalization of an occluded MCA branch. Changes in regional cerebrovascular hemoglobin saturation of the affected left frontal lobe were observed immediately after intraarterial injection of urokinase (UK).


RESULTS
A steady increase in regional oxygen saturation (rSO2) was observed until recanalization was confirmed angiographically as a result of 300,000 IU of UK.


CONCLUSIONS
Monitoring of cerebrovascular hemoglobin saturation by NIRS is a simple, noninvasive technique suggesting its potential for intraoperative monitoring during interventional neuroradiologic procedures.
Nagashima
H
H
Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.
Okudera
H
H
Kobayashi
S
S
Iwashita
T
T
D000368:Aged; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D002533:Cerebral Angiography; D002560:Cerebrovascular Circulation; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D010100:Oxygen / Q000378:metabolism; D010960:Plasminogen Activators / Q000627:therapeutic use; D019265:Spectroscopy, Near-Infrared; D015912:Thrombolytic Therapy; D014057:Tomography, X-Ray Computed; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D006454:Hemoglobins; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator; D010100:Oxygen