Metastatic angiosarcoma of the spleen after accidental radiation exposure: a case report.
Angiosarcoma is a rare malignant tumor arising from endothelial cells of blood vessels or lymphatic channels. Therapeutic irradiation, thoriumdioxide administration, pyothorax, and polyvinyl chloride exposure have been shown to be predisposing factors for developing angiosarcoma. Accidental radiation exposure has not been associated with angiosarcoma. We present an unusual case of angiosarcoma of the spleen, with metastases to bone, liver, breast, and bone marrow, in a woman who lived near the Chernobyl nuclear facility in the former Soviet Union at the time of the reactor accident in 1986. To the best of our knowledge, this is the first report of metastatic angiosarcoma after accidental radiation exposure.
Geffen
D B
DB
Department of Oncology, Soroka Medical Center of Kupat Holim and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Zirkin
H J
HJ
Mermershtain
W
W
Cohen
Y
Y
Ariad
S
S
D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000209:etiology* / Q000556:secondary; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced; D011210:Power Plants; D018788:Radioactive Hazard Release; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D014455:Ukraine