Reciprocal links between metabolic and ionic events in islet cells. Their relevance to the rhythmics of insulin release.
The notion of reciprocal links between metabolic and ionic events in islet cells and the rhythmics of insulin release is based on (i) the rhythmic pattern of hormonal release from isolated perfused rat pancreas, which supports the concept of an intrapancreatic pacemaker; (ii) the assumption that this phasic pattern is due to the integration of secretory activity in distinct functional units, e.g. distinct islets; and (iii) the fact that reciprocal coupling between metabolic and ionic events is operative in the secretory sequence.
Malaisse
W J
WJ
W.J. Malaisse, Laboratory of Experimental Medicine, Brussels Free University, Belgium.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D066298:In Vitro Techniques; D007477:Ions; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D009991:Oscillometry; D010179:Pancreas / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical
D007477:Ions; D001120:Arginine; D005947:Glucose