Relationship between hippocampal theta-wave frequency and emotional behaviors in rabbits produced with stresses or psychotropic drugs.
The hippocampal EEG power spectra of rabbits were analyzed to clarify the relationship between the theta-wave and emotionality. The relative power of T2 (6.0-7.9 Hz)/T1 (4.0-5.9 Hz) represented the index of theta-wave change. Emotional excitement (produced with novelty stress or methamphetamine) or suppression (produced with restraint stress or reserpine) increased or decreased T2/T1 ratios within around +/- 1 Hz changes. Furthermore, the imaging patterns of the peak feature make possible detailed characterization of emotional states. These results suggest that the hippocampus finely adjusts the theta-wave on a +/- 1 Hz level, with a fine balance of voltage, in response to the emotional activity.
Yamamoto
J
J
Pharmacology Section, Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001007:Anxiety; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D005239:Fear; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008694:Methamphetamine / Q000494:pharmacology; D011597:Psychomotor Performance / Q000187:drug effects*; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology; D012146:Rest; D013312:Stress, Physiological / Q000503:physiopathology*; D013826:Theta Rhythm / Q000187:drug effects*; D014851:Wakefulness
D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D012110:Reserpine