title: Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms.
abstract: The image reconstruction enhancement schemes of total variation minimization, dual meshing and iterative spatial filtering have been applied to laboratory data collected from continuous light illumination of tissue-like phantoms. Experiments include both single- and multi-target cases where variations in object size (4 mm to 20 mm), position (centred to near boundary) and contrast with the background (2:1 to 8:1) have been explored. The results show that dramatic improvements in image quality have been obtained in terms of geometric and spatial resolution measures relative to those previously reported for continuous light, but quantitative information on the actual optical properties of embedded heterogeneities is still lacking. Specifically, the geometric characteristics of object size, position and shape are generally accurate to 10-20% and the spatial resolution metrics of background-to-object size and neighbouring-edge separation are approximately 10:1. Direct comparisons are also made with images obtained with intensity-modulated light under identical experimental conditions. Images from intensity-modulated light are found to be superior to continuous light in several important ways, most notably in terms of the ability to quantitatively discriminate the optical property values of embedded targets from the surrounding background. Continuous-light images are also found to have centrally located artefacts in many instances which do not appear in the corresponding intensity-modulated cases.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.forename: K D
authors.initials: KD
authors.lastname: Paulsen
authors.forename: U L
authors.initials: UL
authors.lastname: Osterberg
authors.forename: M S
authors.initials: MS
authors.lastname: Patterson
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data; D008027:Light; D019047:Phantoms, Imaging