title: Joint fluid enhancement at MRI of the glenohumeral joint with intravenous injection of gadodiamide in standard and triple dose: a prospective comparative study of stable and unstable shoulders.
abstract: OBJECTIVE
  To investigate the joint fluid enhancement at MRI of unstable and stable glenohumeral joints after intravenous administration of different doses of gadodiamide.
  
  
  METHODS
  Fourteen patients with unilateral anterior shoulder instability and six healthy controls had both shoulders examined on two occasions using either a standard dose (0.1 mmol/kg) or a triple dose (0.3 mmol/kg) of gadodiamide in an open MRI magnet (0.2 T).
  
  
  CONCLUSIONS
  The joint fluid enhancement in the unstable shoulders was on average 134% following the lower dose and 182% for the triple dose, whereas corresponding values in the stable shoulder in the same individuals were 69% and 142%, and (65% and 159%) in the healthy controls. Enhancement of the joint fluid was higher after the triple dose than after the standard dose in both the unstable shoulders (P < 0.0001) and the controls (P < 0.0005). Compared with the stable controls enhancement in the unstable shoulders was higher for the lower dose (P < 0.0001) while there was no significant difference between the groups following the higher dose. The improved enhancement following the higher dose was especially evident in stable shoulders, while the lower dose was found satisfactory for unstable shoulders.
authors.affiliation: Department of Orthopedics, Uppsala University Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Wintzell
authors.forename: Y
authors.initials: Y
authors.lastname: Haglund-Akerlind
authors.forename: H
authors.initials: H
authors.lastname: Larsson
authors.forename: K
authors.initials: K
authors.lastname: Zyto
authors.forename: S
authors.initials: S
authors.lastname: Larsson
mesh_terms: D000293:Adolescent; D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage*; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D006833:Hydrarthrosis / Q000150:complications / Q000175:diagnosis*; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D011446:Prospective Studies; D012008:Recurrence; D012783:Shoulder Dislocation / Q000150:complications / Q000175:diagnosis*; D012785:Shoulder Joint / Q000473:pathology*
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA