title: Maternal reproductive history and the occurrence of Down's syndrome.
abstract: Reproductive history of mothers of 115 Down's syndrome children was studied and compared with 200 control mothers who gave birth to normal children. The frequency of spontaneous abortions in mothers of Down's syndrome babies was found to be elevated significantly (p < 0.05). The data suggest that the maternal health and reproductive potential have a prominent aetiological significance in the occurrence of Down's syndrome.
authors.affiliation: Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad.
authors.forename: V B
authors.initials: VB
authors.lastname: Rao
authors.forename: C K
authors.initials: CK
authors.lastname: Kumari
authors.forename: M
authors.initials: M
authors.lastname: Sujatha
authors.forename: G S
authors.initials: GS
authors.lastname: Isaac
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D016022:Case-Control Studies; D004314:Down Syndrome / Q000209:etiology* / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D009030:Mosaicism; D011247:Pregnancy; D017584:Reproductive History; D014314:Trisomy