[In vitro models for the study of nerve lesions and potential neuroprotective drugs].
BACKGROUND
In order to study the neurotoxic effects of drugs and to search for neuroprotective agents, we need simple models that permit a quick screening of thousands of compounds. In vitro models with cellular cultures fulfill all this criteria and they are very appropriate to study the mechanism of action of drugs. As adult neurons are very difficult to maintain in culture, this kind of studies are carried out with fetal neurons, tumoral cells or chromaffin cells.


CONCLUSIONS
This in vitro models have shown the neuroprotective effect of glutamate antagonists, calcium-channel blockers, free radical scavengers and other agents as CDP-choline, that promotes cellular membranes restoration.
Abad-Santos
F
F
Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, España.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology*; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D002478:Cells, Cultured; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000494:pharmacology* / Q000627:therapeutic use; D008954:Models, Biological; D009474:Neurons / Q000187:drug effects* / Q000473:pathology*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D018691:Excitatory Amino Acid Antagonists; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents
Modelos in vitro para el estudio de la lesión neuronal y de fármacos potencialmente neuroprotectores.