P53 tumour suppressor gene and germ cell neoplasia.
P53 tumour suppressor gene mutations occur in approximately 50% of common solid tumours such as breast, colon and lung. In contrast, p53 gene mutations occur infrequently (< 3%) in germ cell tumours, even though p53 protein is expressed at high levels in the vast majority of tumour samples. P53-regulated genes are not correspondingly over-expressed in germ cell tumour samples and cell lines, indicating that p53 functions poorly as a transcription factor in this tumour type. High levels of wild-type p53 may contribute, in part, to the chemosensitivity of germ cell tumours.
Lutzker
S G
SG
Cancer Institute of New Jersey, Robert Wood Johnson Medical School-University of Medicine and Dentistry of New Jersey, New Brunswick 08901, USA.
D000818:Animals; D005260:Female; D016147:Genes, Tumor Suppressor; D018237:Germinoma / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53