title: Effect of asthma and its treatment on growth: four year follow up of cohort of children from general practices in Tayside, Scotland.
abstract: OBJECTIVE
  To investigate whether asthma or its treatment impairs children's growth, after allowing for socioeconomic group.
  
  
  METHODS
  4 year follow up of a cohort of children aged 1-15.
  
  
  METHODS
  12 general practices in the Tayside region of Scotland.
  
  
  METHODS
  3347 children with asthma or features suggestive of asthma registered with the general practices.
  
  
  METHODS
  Height and weight standard deviation scores.
  
  
  RESULTS
  Children who lived in areas of social deprivation (assessed by postcode) had lower height and weight than their contemporaries (mean standard deviation score -0.26 (SD 1.02) and -0.18 (1.15) respectively, P < 0.001 for both). Children who were receiving > or = 400 micrograms daily of inhaled steroids and who were attending both hospital and general practice for asthma care had lower height and weight than average, independent of the effect of deprivation (mean standard deviation score -0.62 (1.01), P = 0.002, for height and -0.58 (0.94), P = 0.005, for weight). Children receiving high doses of inhaled corticosteroids also showed lower growth rates (mean change in standard deviation score -0.19 (0.51), P = 0.003). However, no other children with asthma showed growth impairment.
  
  
  CONCLUSIONS
  Most children with asthma were of normal height and weight and had normal growth rates. However, children receiving high doses of inhaled steroids and requiring both general practice and hospital services had a significant reduction in their stature. This effect was independent from but smaller than the effect of socioeconomic group on stature.
authors.affiliation: Tayside Centre for General Practice, University of Dundee.
authors.forename: C
authors.initials: C
authors.lastname: McCowan
authors.forename: R G
authors.initials: RG
authors.lastname: Neville
authors.forename: G E
authors.initials: GE
authors.lastname: Thomas
authors.forename: I K
authors.initials: IK
authors.lastname: Crombie
authors.forename: R A
authors.initials: RA
authors.lastname: Clark
authors.forename: I W
authors.initials: IW
authors.lastname: Ricketts
authors.forename: A Y
authors.initials: AY
authors.lastname: Cairns
authors.forename: F C
authors.initials: FC
authors.lastname: Warner
authors.forename: S A
authors.initials: SA
authors.lastname: Greene
authors.forename: E
authors.initials: E
authors.lastname: White
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D001827:Body Height; D002648:Child; D002657:Child Development; D002662:Child Health Services / Q000706:statistics & numerical data; D002675:Child, Preschool; D015331:Cohort Studies; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007223:Infant; D010342:Patient Acceptance of Health Care; D012606:Scotland / Q000453:epidemiology; D012959:Socioeconomic Factors