Application of micellar electrokinetic chromatography for analyzing antiviral drugs in pharmaceutical semisolid formulations.
The application of micellar electrokinetic chromatography (MEKC) to the determination of the antiviral drugs brivudin (BV) and aciclovir (AC) in pharmaceutical semisolid formulations was studied. A method was developed for separating AC and BV both from hydrophilic and from lipophilic semisolid formulations and for the rapid determination of BV and AC using MEKC. The detection limit, the effective mobility and the relative standard deviation of the migration times and of the peak areas were determined.
Neubert
R H
RH
Institute of Pharmaceutics and Biopharmaceutics, Martin-Luther-University, Halle/Saale, Germany.
Mrestani
Y
Y
Schwarz
M
M
Colin
B
B
D000998:Antiviral Agents / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D008823:Micelles; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012680:Sensitivity and Specificity
D000998:Antiviral Agents; D008823:Micelles; D004364:Pharmaceutical Preparations