title: Onset of hepatocellular carcinoma in a non-cirrhotic patient affected with haemochromatosis.
abstract: The increased incidence of hepatocellular carcinoma in patients affected with haemochromatosis has previously been attributed to cirrhosis. However, some cases of hepatocellular carcinoma without cirrhosis have recently been reported in patients with haemochromatosis, leading to reconsideration of the role of iron in the tumorigenesis of hepatocellular carcinoma. We describe a 79 year old male patient affected with haemochromatosis and with a multinodular hepatocellular carcinoma, but without any evidence of cirrhosis. The absence of any other cancer risk factor (alcohol abuse, liver viral infections, heredity) has lead us to reconsider the possible role of iron as a direct carcinogen in the onset of hepatocellular carcinoma in patients with haemochromatosis.
authors.affiliation: IST, Istituto Nazionale per la ricerca sul cancro, Sezione di Roma, Via A. Baldovinetti 83, Rome, 00142, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Tomao
authors.forename: A
authors.initials: A
authors.lastname: Romiti
authors.forename: A
authors.initials: A
authors.lastname: Mozzicafreddo
authors.forename: M
authors.initials: M
authors.lastname: Raffaele
authors.forename: A
authors.initials: A
authors.lastname: Zullo
authors.forename: A
authors.initials: A
authors.lastname: Antonaci
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000150:complications* / Q000473:pathology; D006432:Hemochromatosis / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D008297:Male; D012307:Risk Factors
chemical_list: D007501:Iron