title: High-dose rate iridium192 afterloading therapy in combination with external beam irradiation for localized prostate cancer.
abstract: Development of afterloading techniques in combination with external radiotherapy allows for curative therapy modality for stage C prostate cancer. Between 10/92 and 12/95 128 patients were treated. Stage B and C tumors were found in 36 and 89 cases, respectively. All patients were pathologically proven to be node-negative by laparoscopic node dissection of the fossa obturatoria region. 9 Gy a week was applied during the first and second weeks of treatment (10/92-12/93: 10 Gy each week) interstitially with high-dose rate iridium192 brachytherapy to the prostate. After this, a four-field box of external beam radiation therapy was given to the prostate to a dose of 45 Gy/25 fractions (10/92-12/93: 40 Gy/20 fractions). Before starting treatment median PSA was 13.8 ng/ml. The median PSA 3, 12, and 24 months after completion of therapy was 1.2, 0.78, and 0.75 ng/ml, respectively. Negative biopsies 12 and 24 months after therapy were observed in 56% (49/87) and 72% (31/43), respectively.
authors.affiliation: Department of Urology, Charité Hospital, Humboldt University of Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Deger
authors.forename: S
authors.initials: S
authors.lastname: Dinges
authors.forename: J
authors.initials: J
authors.lastname: Roigas
authors.forename: D
authors.initials: D
authors.lastname: Schnorr
authors.forename: I
authors.initials: I
authors.lastname: Turk
authors.forename: V
authors.initials: V
authors.lastname: Budach
authors.forename: W
authors.initials: W
authors.lastname: Hinkelbein
authors.forename: S A
authors.initials: SA
authors.lastname: Loening
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000532:radiotherapy*; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D007496:Iridium Radioisotopes / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D011829:Radiation Dosage; D016896:Treatment Outcome
chemical_list: D007496:Iridium Radioisotopes