Nucleotide sequence of nucleocapsid protein (N) of Hantaan virus isolated from a Korean hemorrhagic fever patient.
The nucleotide sequence of the nucleocapsid protein (N) coding region of a Hantaan virus strain (CFC94-2) isolated from a Korean Hemorrhagic Fever (KHF) patient was determined by sequencing a series of deletion mutants. Comparison of the N coding sequence of CFC94-2 to the sequence of the prototype of Hantaan virus, strain 76-118 reveals a 4.97% difference in the nucleotide sequence and a 1.6% difference in the deduced amino acid sequence. The rate of amino acid sequence variation in N protein of different Hantaan viruses (1.6%) is quite similar to that in G1 and G2 envelope proteins (1.7%). These results suggest that N protein may be under a similar selection pressure to G1 and G2 envelope proteins against host immune system.
Lee
S H
SH
Research and Development Center, Cheiljedang Corporation, Korea.
Hong
S P
SP
Shin
Y C
YC
Noh
K S
KS
Kim
H S
HS
Kim
S O
SO
D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D014644:Genetic Variation; D018063:Hantaan virus / Q000737:chemistry*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000821:virology*; D006801:Humans; D007723:Korea; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017421:Sequence Analysis; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014758:Viral Core Proteins / Q000235:genetics*
D036022:Capsid Proteins; D014758:Viral Core Proteins; C111782:nucleocapsid protein, Hantaan virus