Prevalence of coronary calcification in relation to age, gender and risk factor profile in the insight population.
Calcium controls numerous events within the vessel wall. Permeability of the endothelium is calcium dependent. Calcium is also essential for penetration of low-density lipoprotein particles through the endothelium as well as the monocytes that travel through the subendothelial space. Other calcium-dependent processes include platelet activation and adhesion, vascular smooth muscle proliferation and migration, and synthesis of fibrous connective tissue in the subendothelial space. Current evidence indicates that calcium channel blockers retard the development of atherosclerosis in monkeys and rabbits. Human trials have evaluated sequential coronary angiograms in patients undergoing coronary angiography for symptomatic coronary artery disease. Double helix computerised tomography is a non-invasive technique that can detect, measure and compare calcification in the coronary arteries. Our objectives are to determine whether the use of nifedipine vs diuretics in hypertensive patients at high risk of coronary calcification will arrest or slow the progression of calcification in the coronary arteries, and to assess the effect of the two drugs on left ventricular hypertrophy, and left ventricular mass as well as on changes in left ventricular function.
Motro
M
M
Cardiac Rehabilitation Institute, Sheba Medical Center, Tel-Aviv University Sackler School of Medicine, Tel-Hashomer, Israel.
Shemesh
J
J
D002114:Calcinosis / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000453:epidemiology / Q000517:prevention & control*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D015995:Prevalence; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
D002121:Calcium Channel Blockers; D009543:Nifedipine