title: Observations on the treatment of natural haemosporidia infections by total alkaloid of Peganum harmala L. in cattle.
abstract: Eighty two cattle naturally infected with haemosporidians were treated with total alkaloid hydrochloride of Peganum harmale L. (0.5 mg/kg/day). Fifty eight cases with Theileria sergenti showed a cure rate of 86%; thirteen cases with Theileria annulata showed a cure rate of 85%; eight cattle infected with Babesia bigemina showed a cure rate of 88% and three cases of Anaplasma marginale were completely cured. The results suggested that the curative effect of total alkaloid of P. harmale was better than that of diminazene aceturate and produced minimal side effects. The alkaloid could also be administered to pregnant animals. It was concluded that the total alkaloid of P. harmale showed a marked effect as a treatment for haemosporidican infections in cattle.
authors.affiliation: Institute of Traditional Chinese Veterinary Medicine, Chinese Academy of Agricultural Sciences, Lanzhou, People's Republic of China.
authors.forename: T
authors.initials: T
authors.lastname: Hu
authors.forename: B
authors.initials: B
authors.lastname: Fan
authors.forename: J
authors.initials: J
authors.lastname: Liang
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.forename: P
authors.initials: P
authors.lastname: Dang
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.forename: M
authors.initials: M
authors.lastname: Dong
mesh_terms: D000470:Alkaloids / Q000627:therapeutic use*; D000712:Anaplasmosis / Q000188:drug therapy; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001404:Babesiosis / Q000188:drug therapy*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D002681:China; D005260:Female; D018512:Parasitemia / Q000662:veterinary; D010936:Plant Extracts / Q000627:therapeutic use*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy; D013801:Theileriasis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000470:Alkaloids; D000981:Antiprotozoal Agents; D010936:Plant Extracts