title: Hypocortisolaemia in a Labrador retriever.
abstract: A four-year-old Labrador retriever was presented with lethargy and exercise intolerance. Clinical examination was unremarkable. A subnormal cortisol response to adrenocorticotrophin hormone (ACTH) was demonstrated (plasma cortisol concentrations before and after administration of ACTH were both below the detection limit of the assay) but plasma aldosterone concentrations were within the normal range. Endogenous plasma ACTH concentrations were high, indicating primary adrenocortical disease. Following glucocorticoid supplementation at a replacement dose (prednisolone 0.1 mg/kg) the dog made a full clinical recovery.
authors.affiliation: Department of Clinical Veterinary Medicine, University of Cambridge.
authors.forename: K J
authors.initials: KJ
authors.lastname: Dunn
authors.forename: M E
authors.initials: ME
authors.lastname: Herrtage
mesh_terms: D000224:Addison Disease / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone; D000450:Aldosterone / Q000097:blood* / Q000378:metabolism; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004283:Dog Diseases; D004285:Dogs; D005080:Exercise Test / Q000662:veterinary; D006854:Hydrocortisone / Q000097:blood* / Q000172:deficiency; D008297:Male; D009919:Orchiectomy; D010100:Oxygen / Q000097:blood; D011239:Prednisolone / Q000627:therapeutic use*
chemical_list: D002245:Carbon Dioxide; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D011239:Prednisolone; D010100:Oxygen; D006854:Hydrocortisone