Disseminated neonatal Trichosporon beigelii infection: successful treatment with liposomal amphotericin B.
Trichosporon beigelii, normally a low grade pathogen, can cause disseminated infection in neonates with a high associated mortality. We report a case in a 25-week gestation, 950 g female infant who had evidence of disseminated infection yet survived after treatment with the Liposomal form of Amphotericin B without any evidence of drug-induced adverse effects. A review of previous reported cases shows this form of disseminated mycosis to be rare and almost always fatal.
Sweet
D
D
Royal Maternity Hospital Neonatal Unit, Belfast, UK.
Reid
M
M
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004337:Drug Carriers; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008081:Liposomes; D009181:Mycoses / Q000188:drug therapy* / Q000635:transmission; D014250:Trichosporon / Q000302:isolation & purification
D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B