title: Power Doppler sonography to evaluate response to percutaneous ethanol injection in hepatocellular carcinoma.
abstract: OBJECTIVE
  The aim of the present study was to compare power Doppler imaging with traditional color Doppler imaging and with contrast enhanced computer tomography in the evaluation of intratumoral vascularity of hepatocellular carcinomas at diagnosis and in response to percutaneous ethanol injection.
  
  
  METHODS
  Sixteen patients with hepatocellular carcinoma underwent colour Doppler, power Doppler and computed tomography at diagnosis. Seventeen patients were studied by the three techniques one month after percutaneous ethanol injection treatment.
  
  
  RESULTS
  At baseline evaluation, power Doppler and color Doppler were always in agreement and, with the exception of one case, were also in agreement with the computerized tomography scan. On the contrary, power Doppler and computerized tomography are more sensitive than color Doppler in the evaluation of residual vascularized tumoral tissue after percutaneous ethanol injection. In 3 patients, residual vascularity was demonstrated only by computerized tomography while color and power Doppler were negative. In another 3 cases, a positive power Doppler signal, with a typical arterial Doppler spectrum, was observed while color Doppler and computerized tomography were negative. In these patients, cancer relapse was clinically evident after a few months and treatment was repeated to obtain complete necrosis.
  
  
  CONCLUSIONS
  We conclude that only the integration of the results of all these techniques can reliably evaluate tumoral vascularity after percutaneous ethanol injection.
authors.affiliation: Surgery Unit, Incurabili Hospital, Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Spiezia
authors.forename: P
authors.initials: P
authors.lastname: Vallone
authors.forename: F
authors.initials: F
authors.lastname: Fiore
authors.forename: P
authors.initials: P
authors.lastname: Ricchi
authors.forename: B
authors.initials: B
authors.lastname: Daniele
authors.forename: G
authors.initials: G
authors.lastname: Picone
authors.forename: G
authors.initials: G
authors.lastname: Cerbone
authors.forename: R
authors.initials: R
authors.lastname: De Vivo
authors.forename: F
authors.initials: F
authors.lastname: Perrone
authors.forename: F
authors.initials: F
authors.lastname: Castiglione
authors.forename: S
authors.initials: S
authors.lastname: Pignata
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D003287:Contrast Media; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008297:Male; D008833:Microcirculation / Q000000981:diagnostic imaging; D008875:Middle Aged; D011379:Prognosis; D011856:Radiographic Image Enhancement; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D018608:Ultrasonography, Doppler; D018615:Ultrasonography, Doppler, Color
chemical_list: D003287:Contrast Media; D000431:Ethanol