title: Hyponatremic seizure in a child using desmopressin for nocturnal enuresis.
abstract: BACKGROUND
  Intranasal desmopressin has been used extensively to treat primary nocturnal enuresis. While it has proven to be a safe, effective agent for many who are affected by this condition, the potential for complications exists.
  
  
  OBJECTIVE
  To report a case of severe hyponatremia associated with a generalized tonic-clonic seizure in a 10-year-old boy who had been receiving intranasal desmopressin nightly for nocturnal enuresis and to briefly review therapeutic options for nocturnal enuresis; and to present the role of desmopressin.
  
  
  METHODS
  Georgetown University Medical Center, Washington, DC.
  
  
  METHODS
  Fluid restriction and intravenous isotonic saline solution with 5% dextrose was administered to raise the serum sodium level.
  
  
  RESULTS
  Prevention of further seizures with normalization of serum sodium levels without any obvious neurological sequelae.
  
  
  CONCLUSIONS
  This case illustrates the importance of weighing the benefits and risks of intranasal desmopressin therapy.
authors.affiliation: Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Donoghue
authors.forename: M E
authors.initials: ME
authors.lastname: Latimer
authors.forename: H L
authors.initials: HL
authors.lastname: Pillsbury
authors.forename: J H
authors.initials: JH
authors.lastname: Hertzog
mesh_terms: D002648:Child; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects* / Q000627:therapeutic use; D004775:Enuresis / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000150:complications; D008297:Male; D012076:Renal Agents / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D012076:Renal Agents; D003894:Deamino Arginine Vasopressin