The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier.
Khan
E U
EU
King's College, London, UK.
Reichel
A
A
Begley
D J
DJ
Roffey
S J
SJ
Jezequel
S G
SG
Abbott
N J
NJ
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002460:Cell Line; D003078:Colchicine / Q000378:metabolism*; D016572:Cyclosporine / Q000737:chemistry / Q000494:pharmacology; D004176:Dipyridamole / Q000737:chemistry / Q000494:pharmacology; D008055:Lipids / Q000737:chemistry*; D051381:Rats; D012995:Solubility; D014700:Verapamil / Q000737:chemistry / Q000494:pharmacology; D015215:Zidovudine / Q000737:chemistry / Q000494:pharmacology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008055:Lipids; D015215:Zidovudine; D004176:Dipyridamole; D016572:Cyclosporine; D014700:Verapamil; D003078:Colchicine