title: Autonomic regulation of gastric ulcerogenesis after cervical cord transection in the rat.
abstract: OBJECTIVE
  To examine the role of anticholinergic and sympathomimetic drugs in preventing gastric ulcerogenesis after cervical cord transection (CCT) in the rat.
  
  
  METHODS
  A randomized, prospective, interventional trial was performed comparing pirenzepine (muscarinic type I receptor antagonist) and ephedrine (nonspecific sympathomimetic) in the prevention of gastric ulcerogenesis after CCT in the rat. After isoflurane-induced general anesthesia, group 1 (n = 12) received sham CCT with no pretreatment, group 2 received CCT with no pretreatment, group 3 received CCT with pirenzepine pretreatment (0.01/mg/kg IP), and group 4 received CCT with ephedrine pretreatment (3 mg/kg IP). Six hours after intervention, all the rats were euthanized with isoflurane, stomachs were dissected, and a gastric ulcer index was determined.
  
  
  RESULTS
  The mean (+/- SD) ulcer index was 0.08 +/- 0.1 for group 1, 2.33 +/- 0.5 for group 2 (p = 0.01), 0.41 +/- 0.7 for group 3 (p = 0.037 compared with group 2), and 0.75 +/- 0.7 for group 4 (p = 0.0005 compared with group 2). Groups 3 and 4 were not significantly different from each other (p = 0.30).
  
  
  CONCLUSIONS
  Gastric ulcerogenesis after CCT in the rat is decreased by anticholinergic and sympathomimetic drug pretreatment.
authors.affiliation: Department of Emergency Medicine, Earl K. Long Medical Center, Baton Rouge, LA 70805, USA. rwaldrop@pol.net
authors.forename: R D
authors.initials: RD
authors.lastname: Waldrop
authors.forename: G M
authors.initials: GM
authors.lastname: Strain
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004809:Ephedrine / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology*; D010890:Pirenzepine / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord; D018709:Statistics, Nonparametric; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological; D013566:Sympathomimetics / Q000494:pharmacology*
chemical_list: D000897:Anti-Ulcer Agents; D018727:Muscarinic Antagonists; D010276:Parasympatholytics; D013566:Sympathomimetics; D010890:Pirenzepine; D004809:Ephedrine