title: A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervix.
abstract: Adenoma malignum (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p13.2-13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker D19S216. This result indicates that a putative tumor suppressor gene for AM is located at D19S216 on chromosomal band 19p13.3 and plays an important role in AM tumorigenesis.
authors.affiliation: Department of Pathology and Cancer Research Institute, Catholic University Medical College, Seoul, Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
authors.forename: S M
authors.initials: SM
authors.lastname: Dong
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: E Y
authors.initials: EY
authors.lastname: Na
authors.forename: M S
authors.initials: MS
authors.lastname: Shin
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: W S
authors.initials: WS
authors.lastname: Park
authors.forename: K M
authors.initials: KM
authors.lastname: Kim
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: J J
authors.initials: JJ
authors.lastname: Jang
authors.forename: N J
authors.initials: NJ
authors.lastname: Yoo
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000236:Adenoma / Q000235:genetics*; D002469:Cell Separation; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity; D010580:Peutz-Jeghers Syndrome / Q000235:genetics*; D017384:Sequence Deletion; D002583:Uterine Cervical Neoplasms / Q000235:genetics*