title: Hydrogen exchange and protein folding.
abstract: Amide hydrogen-deuterium exchange is a sensitive probe of the structure, stability and dynamics of proteins. The significant increase in the number of small, model proteins that have been studied has allowed a better understanding of the structural fluctuations that lead to hydrogen exchange. Recent technical advances enable the methodology to be applied to the study of protein-protein interactions in much larger, more complex systems.
authors.affiliation: Centre for Protein Engineering, MRC Unit for Protein Function and Design, MRC Centre, Cambridge, UK. jc162@cam.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Clarke
authors.forename: L S
authors.initials: LS
authors.lastname: Itzhaki
mesh_terms: D006859:Hydrogen / Q000737:chemistry*; D006860:Hydrogen Bonding; D008956:Models, Chemical; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature
chemical_list: D011506:Proteins; D006859:Hydrogen