Analysis of recovery time indexes in 5-fluorouracil-treated cancer patients.
Based on our previous experience in doxorubicin-treated patients, in whom we observed a significant increase of ventricular recovery time indexes, we analyzed these non- invasive parameters of myocardium electrical instability in forty-three 5-fluorouracil-treated patients, to test the hypothesis of a mechanoelectrical disarrangement occurring in 5-fluorouracil (5FU) cardiotoxicity. All patients enrolled were studied at the first presentation and following chemotherapy. The study showed the absence of any significant changes in recovery time indexes or in other electrocardiographic parameters. Our data suggest that 5FU does not interfere with electrical properties of myocardial fibers.
Orditura
M
M
Division of Medical Oncology, Department of Internal and Experimental Medicine, Second University of Medical School of Naples c/o II Policlinico, III Padiglione, Via S. Pansini n. 5, Naples, 80131, Italy.
De Vita
F
F
Sarubbi
B
B
Ducceschi
V
V
Auriemma
A
A
Infusino
S
S
Iacono
A
A
Catalano
G
G
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D012189:Retrospective Studies; D016276:Ventricular Function / Q000502:physiology*
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil