title: Effects of feeding a liquid diet for one year to New Zealand White rabbits.
abstract: We compared the long-term effects of a newly designed liquid diet with a commercially available dry diet in New Zealand White rabbits. Body weight gain, feed consumption, and plasma lipid concentrations were measured periodically throughout the 1-year study. In addition, specific hepatic enzyme activities in serum were quantified to examine the effects of liquid diet on the liver over the 1-year feeding trial. At 52 weeks, body weight gains between the liquid- and dry-fed groups were similar. Regardless of sex, plasma phospholipid concentrations were higher in the control group than in the liquid-fed group. Plasma triglyceride concentrations were increased in liquid-fed female rabbits, compared with either male group or control-fed females. A somewhat similar effect was observed in plasma cholesterol concentration, which was higher in female rabbits regardless of diet type. After the 52-week trial, the rabbits had no clinical biochemical signs of liver damage. Results of this study indicate that a liquid diet can be fed to New Zealand White rabbits for a long period, and may provide an alternative route (food source) for future pathophysiologic studies.
authors.affiliation: Department of Animal Sciences, Purdue University, West Lafayette, Indiana 47907-1151, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Latour
authors.forename: D
authors.initials: D
authors.lastname: Hopkins
authors.forename: T
authors.initials: T
authors.lastname: Kitchens
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Schonfeld
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004435:Eating; D005260:Female; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D010743:Phospholipids / Q000097:blood; D011817:Rabbits / Q000502:physiology*; D012996:Solutions; D015430:Weight Gain
chemical_list: D008055:Lipids; D010743:Phospholipids; D012996:Solutions; D002784:Cholesterol