Successful treatment of in-transit metastases from Merkel's cell carcinoma with isolated hyperthermic limb perfusion.
Merkel's cell carcinoma is an uncommon neuroendocrine cutaneous neoplasm. An unusual mode of dissemination of this tumor is the phenomenon of in-transit metastases. We report complete resolution of in-transit metastases from a Merkel's cell carcinoma in response to treatment with isolated hyperthermic limb perfusion with melphalan. Limb perfusion appears to be a promising modality for such lesions.
Gupta
A S
AS
Department of Surgery, Louisiana State University and the Stanley S. Scott Cancer Center, New Orleans 70112, USA.
Heinzman
S
S
Levine
E A
EA
D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D015266:Carcinoma, Merkel Cell / Q000188:drug therapy* / Q000473:pathology*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008207:Lymphatic Metastasis; D008297:Male; D008558:Melphalan / Q000008:administration & dosage*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology*
D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan