Effect of the EGb 761 (Ginkgo bilboa extract) on primary immune response in experimental chronic stress.
The effect of a chronic stress upon the primary immune response on mice was evaluated by using the plaque-forming cells (PFC)-direct technique, which allowed us to record a serious suppression of the immune response in the exposed animals. In the next phase of the experiment a second group was initially treated with Tanakan (EGb 761--Ginkgo biloba extract) and then it was submitted to the same chronic stress: this procedure did not bring about the increase of the number of lymphocytes but it significantly improved the function of these cells.
Turcan
M
M
Department of Physiology, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Cozmei
C
C
Carasevici
E
E
Haulică
I
I
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D020441:Ginkgo biloba; D006462:Hemolytic Plaque Technique; D007114:Immunization / Q000379:methods; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D012149:Restraint, Physical; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013315:Stress, Psychological / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors; D000096983:Ginkgo Extract
D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract