title: Assessment of disease activity in systemic vasculitis.
abstract: The systemic vasculitides are a group of inflammatory disorders characterised by relapses and remission. Before the introduction of immunosuppressive drugs, mortality was unacceptably high. Immunosuppressive therapy has had a therapeutic impact, but at the cost of increased risk of infection and other adverse effects. Differentiating infection from active disease can be difficult, and the inappropriate prescription of immunosuppressive drugs can be fatal. Hence disease indices which can aid physicians to identify the active phase of disease and enable early treatment, will be valuable in the management of this group of disorders.
authors.affiliation: Department of Medicine, CCRIS, Medical School, University of Birmingham, UK.
authors.forename: W Y
authors.initials: WY
authors.lastname: Tse
authors.forename: P
authors.initials: P
authors.lastname: Cockwell
authors.forename: C O
authors.initials: CO
authors.lastname: Savage
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D015415:Biomarkers; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D006801:Humans; D011237:Predictive Value of Tests; D015375:Receptors, Interleukin-2 / Q000032:analysis; D014657:Vasculitis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D015375:Receptors, Interleukin-2; D014841:von Willebrand Factor; D002097:C-Reactive Protein