Oculomotor abnormalities in schizophrenia: a critical review.
Oculomotor abnormalities, particularly in smooth pursuit tracking, are one of the most widely investigated biological markers of schizophrenia. However, despite the wealth of published data, important questions concerning the exact nature of these abnormalities remain unanswered. Many of the studies use unreliable methodology, and few attempts have been made to interpret the observed oculomotor dysfunction in terms of current understanding of eye movement physiology. Also, the potential effects of antipsychotic medication have been poorly addressed. Recent research, using more reliable measurement techniques and novel saccadic paradigms are producing important results and may provide a more productive framework for future studies of oculomotor abnormalities in schizophrenia.
Hutton
S
S
Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, United Kingdom.
Kennard
C
C
D014150:Antipsychotic Agents / Q000494:pharmacology; D005133:Eye Movements / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009424:Nervous System Physiological Phenomena; D009801:Oculomotor Muscles / Q000503:physiopathology*; D011698:Pursuit, Smooth / Q000502:physiology; D012438:Saccades / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents