Kinetics of chlorhexidine on intact skin following a single application.
Residual chlorhexidine concentrations were measured after application of a single dose on the skin of 22 healthy volunteers. Dosage by high-pressure liquid chromatography in the skin cleansers revealed that the residual concentrations were higher than chlorhexidine MICs for most organisms of the resident skin flora and some responsible for hand-borne infections, even 24 h after application.
Carret
L
L
UPRES E. A. 1655, Hôpital E. Herriot, Lyon, France.
Reverdy
M E
ME
Lafforgue
C
C
Falson
F
F
Fleurette
J
J
Freney
J
J
D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D002710:Chlorhexidine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D015989:Healthy Worker Effect; D006801:Humans; D008297:Male; D015610:Serum Bactericidal Test; D012867:Skin / Q000378:metabolism* / Q000382:microbiology; D014838:Volunteers
D000891:Anti-Infective Agents, Local; D002710:Chlorhexidine