title: Dopamine synthesizing enzymes in paraventricular hypothalamic neurons of the human and monkey (Macaca fuscata).
abstract: Using immunohistochemistry, we demonstrated that paraventricular hypothalamic neurons immunoreactive for tyrosine hydroxylase (TH) were not immunopositive for the second step catecholamine synthesizing enzyme L-amino acid decarboxylase (AADC) in the human and monkey Macaca fuscata. In the latter species, they were not immunoreactive for dopamine. It is most likely that primate paraventricular TH-containing neurons do not synthesize dopamine.
authors.affiliation: Département de Médecine Expérimentale, INSERM U480, Faculté de Médecine, Université Claude Bernard, Lyon, France.
authors.forename: K
authors.initials: K
authors.lastname: Kitahama
authors.forename: K
authors.initials: K
authors.lastname: Ikemoto
authors.forename: A
authors.initials: A
authors.lastname: Jouvet
authors.forename: I
authors.initials: I
authors.lastname: Nagatsu
authors.forename: M
authors.initials: M
authors.lastname: Geffard
authors.forename: H
authors.initials: H
authors.lastname: Okamura
authors.forename: J
authors.initials: J
authors.lastname: Pearson
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000032:analysis / Q000378:metabolism; D004298:Dopamine / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D008251:Macaca / Q000378:metabolism*; D008875:Middle Aged; D009474:Neurons / Q000201:enzymology*; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000378:metabolism
chemical_list: D014446:Tyrosine 3-Monooxygenase; D001142:Aromatic-L-Amino-Acid Decarboxylases; D004298:Dopamine