title: Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets.
abstract: We tested the hypothesis that controlled hypoxemic resuscitation improves early cerebral metabolic and electrophysiological recovery in hypoxic newborn piglets. Severely hypoxic anesthetized piglets were randomly divided into three resuscitation groups: hypoxemic, 21% O2, and 100% O2 groups (8 in each group). The hypoxemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%). Base excess (BE) reached -22 +/- 1 mM at the end of hypoxia. During a 2-h resuscitation period, no significant differences in time to recovery of electroencephalography (EEG), quality of EEG at recovery, or extracellular hypoxanthine concentrations in the cerebral cortex and striatum were found among the groups. BE and plasma hypoxanthine, however, normalized significantly more slowly during controlled hypoxemic resuscitation than during resuscitation with 21 or 100% O2. We conclude that early brain recovery during controlled hypoxemic resuscitation was as efficient as, but not superior to, recovery during resuscitation with 21 or 100% O2. The systemic metabolic recovery from hypoxia, however, was delayed during controlled hypoxemic resuscitation.
authors.affiliation: Department of Pediatric Research and Institute for Surgical Research, The National Hospital, N-0027 Oslo, Norway. bjorn.feet@rh.uio.no
authors.forename: B A
authors.initials: BA
authors.lastname: Feet
authors.forename: N C
authors.initials: NC
authors.lastname: Brun
authors.forename: L
authors.initials: L
authors.lastname: Hellström-Westas
authors.forename: N W
authors.initials: NW
authors.lastname: Svenningsen
authors.forename: G
authors.initials: G
authors.lastname: Greisen
authors.forename: O D
authors.initials: OD
authors.lastname: Saugstad
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography; D004594:Electrophysiology; D006454:Hemoglobins / Q000378:metabolism; D019271:Hypoxanthine / Q000493:pharmacokinetics; D000860:Hypoxia / Q000503:physiopathology*; D017551:Microdialysis; D010100:Oxygen / Q000097:blood; D012151:Resuscitation; D019265:Spectroscopy, Near-Infrared; D013552:Swine
chemical_list: D006454:Hemoglobins; D019271:Hypoxanthine; D010100:Oxygen