title: Cocaine-induced peripheral vascular occlusive disease--a case report.
abstract: Two patients with cocaine-induced peripheral vascular occlusive disease are presented. A 37-year-old man was admitted to the hospital for evaluation of severe pain and numbness of his feet. He had used cocaine prior to admission. Arteriography showed bilateral occlusions of superficial femoral, popliteal, and trifucation arteries. Despite repeated infusions of urokinase, he developed progressive bilateral gangrene of both legs necessitating bilateral below-knee amputations. The second patient developed similar symptoms after smoking cocaine. Arteriography showed vasospasm bilaterally from the iliac arteries distally. I.v. nitroglycerin infusion caused resolution of the vasospasm and ischemic symptoms.
authors.affiliation: Department of Neurology, Louisiana State University School of Medicine, New Orleans 70112, USA.
authors.forename: A
authors.initials: A
authors.lastname: Gutierrez
authors.forename: J D
authors.initials: JD
authors.lastname: England
authors.forename: W C
authors.initials: WC
authors.lastname: Krupski
mesh_terms: D000208:Acute Disease; D000328:Adult; D000792:Angiography; D016578:Crack Cocaine / Q000009:adverse effects*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D016491:Peripheral Vascular Diseases / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D016578:Crack Cocaine