title: Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy.
abstract: BACKGROUND
  In the treatment of lung cancer, the best outcome is achieved when the lesion is discovered in the intraepithelial (preinvasive) stage. However, intraepithelial neoplastic lesions are difficult to localize by conventional white-light bronchoscopy (WLB).
  
  
  OBJECTIVE
  To determine if autofluorescence bronchoscopy, when used as an adjunct to WLB, could improve the bronchoscopist's ability to locate and remove biopsy specimens from areas suspicious of intraepithelial neoplasia as compared with WLB alone.
  
  
  METHODS
  A multicenter clinical trial was conducted in seven institutions in the United States and Canada. WLB followed by fluorescence examination with the light-induced fluorescence endoscopy (LIFE) device was performed in 173 subjects known or suspected to have lung cancer. Biopsy specimens were taken from all areas suspicious of moderate dysplasia or worse on WLB and/or LIFE examination. In addition, random biopsy specimens were also taken from other parts of the bronchial tree.
  
  
  RESULTS
  The relative sensitivity of WLB + LIFE vs WLB alone was 6.3 for intraepithelial neoplastic lesions and 2.71 when invasive carcinomas were also included. The positive predictive value was 0.33 and 0.39 and the negative predictive value was 0.89 and 0.83, respectively, for WLB+LIFE and WLB alone.
  
  
  CONCLUSIONS
  Autofluorescence bronchoscopy, when used as an adjunct to standard WLB, enhances the bronchoscopist's ability to localize small neoplastic lesions, especially intraepithelial lesions that may have significant implication in the management of lung cancer in the future.
authors.affiliation: British Columbia Cancer Agency, Vancouver, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Lam
authors.forename: T
authors.initials: T
authors.lastname: Kennedy
authors.forename: M
authors.initials: M
authors.lastname: Unger
authors.forename: Y E
authors.initials: YE
authors.lastname: Miller
authors.forename: D
authors.initials: D
authors.lastname: Gelmont
authors.forename: V
authors.initials: V
authors.lastname: Rusch
authors.forename: B
authors.initials: B
authors.lastname: Gipe
authors.forename: D
authors.initials: D
authors.lastname: Howard
authors.forename: J C
authors.initials: JC
authors.lastname: LeRiche
authors.forename: A
authors.initials: A
authors.lastname: Coldman
authors.forename: A F
authors.initials: AF
authors.lastname: Gazdar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001980:Bronchi / Q000473:pathology*; D020680:Bronchoscopes; D001999:Bronchoscopy / Q000379:methods; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005453:Fluorescence; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity