[The effects of midazolam on the memory of pain].
The purpose of this study was to evaluate the effects of low dose midazolam (MZ) on memories of spinal puncture. The low doses of MZ were administered to 70 patients (ASA 1-2), of whom 37 patients were premedicated with atropine sulfate 0.5 mg and pethidine hydrochloride i.m. (group P), and 33 patients received no premedication (group N). Double blind randomized trials were conducted with the doses of MZ (0, 0.03, 0.06 mg.kg-1), and MZ was administered i.v. to the patients just prior to spinal puncture. Subjective evaluation of pain was performed with pain score (PS) on postoperative phase, and objective evaluation of pain was performed with the reaction of spinal puncture. Short term memory was impaired mainly after administration of MZ. However, subjective memory of pain almost disappeared, but objective evaluation was not so good. We conclude that MZ induces impairment to recall of pain. However, it might maintain the response to the pain.
Nagahama
H
H
Department of Anesthesiology, St. Marianna University School of Medicine, Kawasaki.
Noda
M
M
Takagi
S
S
Kurosawa
S
S
Miyasato
K
K
Nakagawa
E
E
Okamoto
Y
Y
Tateda
T
T
Aoki
T
T
Morokawa
Y
Y
D000759:Adjuvants, Anesthesia / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008568:Memory / Q000187:drug effects*; D008874:Midazolam / Q000627:therapeutic use*; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D011229:Preanesthetic Medication; D013129:Spinal Puncture / Q000009:adverse effects
D000759:Adjuvants, Anesthesia; D014151:Anti-Anxiety Agents; D008874:Midazolam