title: Alkamides from Phyllanthus fraternus.
abstract: Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.
authors.forename: A A
authors.initials: AA
authors.lastname: Sittie
authors.forename: E
authors.initials: E
authors.lastname: Lemmich
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
authors.forename: L
authors.initials: L
authors.lastname: Hviid
authors.forename: S
authors.initials: S
authors.lastname: Brøgger Christensen
mesh_terms: D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D018320:Leishmania major / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000577:Amides; D000981:Antiprotozoal Agents