[Angiopoietin-2, a new molecular actor involved in vascular tree morphogenesis].
Angiopoietin-2 is a new member of the family of the ligands of Tek (Tie2), a transmembrane receptor with tyrosine kinase activity which is specifically expressed in endothelial cells during angiogenesis. Several lines of evidence indicate that angiopoietin-1 is involved in pericyte recruitment by endothelial cells and in the maintenance of cell-cell and cell matrix association in mature capillaries. Angiopoietin-2 behaves as an antagonist of angiopoietin-1. It is suggested that it looses capillary structure and renders endothelial cells to become responsive to angiogenic stimuli.
Vandenbunder
B
B
CNRS EP560, Institut Pasteur de Lille.
D042702:Angiopoietin-2; D004730:Endothelium, Vascular / Q000166:cytology* / Q000502:physiology; D004791:Enzyme Inhibitors / Q000378:metabolism*; D006801:Humans; D018919:Neovascularization, Physiologic; D011506:Proteins / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology; D040262:Receptors, Vascular Endothelial Growth Factor
D042702:Angiopoietin-2; D004791:Enzyme Inhibitors; D011506:Proteins; D017978:Receptors, Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor
L'angiopoïétine 2, un nouvel acteur moléculaire impliqué dans la morphogenèse de l'arbre vasculaire.