Topical use of miconazole antifungal oral gel on warfarinized patients: a word of caution.
Oral candidosis is common, particularly in elderly patients who wear dentures. Many of these patients also have systemic diseases, including conditions for which they have to take oral anticoagulants, most commonly warfarin. Although the effect of parenterally administered miconazole on anticoagulant control is well known, the fact that small amounts of topically applied miconazole oral gel can have a similar effect is poorly recognized.
Ezsiás
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A
Department of Oral and Maxillofacial Surgery, John Radcliffe Hospital, Oxford.
Wojnarowska
F
F
Juniper
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R
D000284:Administration, Oral; D000287:Administration, Topical; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D000935:Antifungal Agents / Q000008:administration & dosage*; D002180:Candidiasis, Oral / Q000188:drug therapy; D065607:Cytochrome P-450 Enzyme Inhibitors; D017742:Dental Care for Chronically Ill; D004357:Drug Synergism; D005260:Female; D005782:Gels; D006801:Humans; D008825:Miconazole / Q000008:administration & dosage*; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D000935:Antifungal Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D005782:Gels; D014859:Warfarin; D008825:Miconazole