Antimicrobial activity of novel furanonaphthoquinone analogs.
Analogs of furanonaphthoquinone (FNQ) from Tecoma ipe Mart had MICs ranging from 1.56 to 25 microg/ml against gram-positive bacteria. FNQ showed significantly lower MICs against methicillin-resistant Staphylococcus aureus than against methicillin-sensitive S. aureus. FNQ inhibited Helicobacter pylori with an MIC of 0.1 microg/ml. Fungi, including pathogenic species, were sensitive to FNQ with MICs similar to those of amphotericin B.
Nagata
K
K
Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan. kunagata@hyo-med.ac.jp
Hirai
K I
KI
Koyama
J
J
Wada
Y
Y
Tamura
T
T
D001230:Aspergillus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
C111775:2-methyl-8-hydroxynaphtho(2,3-b)furan-4,9-dione; C106805:2-methylnaphtho(2,3-b)furan-4,9-dione; D009285:Naphthoquinones