title: In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants.
abstract: The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. Concentrations of 10(6)M to 10(9)M were associated with a dose dependent inhibition of colony formation, with the most clinically important effects seen on the earliest erythroid and granulocyte-macrophage colonies. Because of the potential clinical implications of these observations, studies are needed to determine the effects of dexamethasone on haematopoiesis in preterm infants.
authors.affiliation: Department of Paediatrics, University of Florida College of Medicine, Gainesville, USA.
authors.forename: P
authors.initials: P
authors.lastname: Papoff
authors.forename: R D
authors.initials: RD
authors.lastname: Christensen
authors.forename: J
authors.initials: J
authors.lastname: Harcum
authors.forename: Y
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D018929:Cell Culture Techniques; D003114:Colony-Forming Units Assay; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015672:Erythroid Precursor Cells / Q000187:drug effects; D004921:Erythropoietin / Q000494:pharmacology; D005312:Fetal Blood / Q000166:cytology / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*
chemical_list: D005938:Glucocorticoids; D004921:Erythropoietin; C004180:dexamethasone 21-phosphate; D003907:Dexamethasone