Inhibition of lipid peroxidation.
Lipid peroxy radicals (ROO.) were detected by electron spin resonance (ESR) at low temperature after formation by addition of H2O2 into a suspension of mice lymphocytes. If lymphocytes were treated with selenomethionine (Se-Met) prior to addition of H2O2, ROO. formation was inhibited in a fashion that was dependent on Se-Met concentration. Formation of ROO. in the spleen of mice was induced by 60Co irradiation. Animals that were supplemented with Na2SeO3 prior to irradiation exhibited a lower ROO. concentration than that of nontreated animals. Based on our experiments, we have concluded that Se has an oxygen-free radical scavenging effect. This should be a protective effect against lipid peroxy radical cellular attack.
Sun
E
E
Chemistry Department, Huazhong University of Science and Technology Wuhan, People's Republic of China.
Xu
H
H
Wen
D
D
Zuo
P
P
Zhou
J
J
Wang
J
J
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D017382:Reactive Oxygen Species; D012645:Selenomethionine / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D017382:Reactive Oxygen Species; D012645:Selenomethionine; D006861:Hydrogen Peroxide