title: Biomarkers of nasal inflammation in wood-surface coating industry workers.
abstract: Upper airway symptoms in workers employed in the manufacture of wood products using ultraviolet radiation curing or acid curing of surface coating have been reported. In this study, workers were divided into groups according to exposure: (1) UV-surface coating line, (2) acid curing surface coating line, (3) finishing processes of UV-cured acrylate coated products, (4) finishing processes of of both UV- and acid cured coated wood products, and (5) control group. The workers were examined with nasal lavage in order to investigate inflammatory signs (ECP, tryptase, albumin and microscopy with cell differential counting). UV-line workers and finishers had significantly increased levels of ECP in nasal lavage. There was a positive correlation between exposure time and ECP and albumin levels. Workers with general nasal complaints and atopics had increased levels of ECP. In this study there were findings indicating an inflammatory process in the nasal mucosa in workers exposed to UV radiation curing multifunctional acrylate coatings. The findings indicate an unspecific inflammation and, therefore, a correlation between occupational exposure to acrylate coatings and nasal inflammation seems probable.
authors.affiliation: Department of Otorhinolaryngology, Huddinge University Hospital, Karolinska Institute, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Granstrand
authors.forename: L
authors.initials: L
authors.lastname: Nylander-French
authors.forename: M
authors.initials: M
authors.lastname: Holmström
mesh_terms: D000179:Acrylates / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D016001:Confidence Intervals; D004391:Dust / Q000009:adverse effects; D005260:Female; D006801:Humans; D007221:Industry; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance; D017817:Nasal Lavage Fluid / Q000166:cytology; D016017:Odds Ratio; D012220:Rhinitis / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D013499:Surface Properties; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014934:Wood
chemical_list: D000179:Acrylates; D000395:Air Pollutants, Occupational; D015415:Biomarkers; D004391:Dust; C036658:acrylic acid