[Effect of ionizing radiation on the mitotic cycle of rat embryonal cells, immortalized by oncogene E1A and transformed by oncogenes E1A and c-Ha-ras].
A comparative study of recovery of mitotic cycle in gamma-irradiated rat embryo fibroblast cells (intact, immortalized with oncogene E1A and transformed with two oncogens-E1A and c-Ha-Ras) was made to show eventually no difference in response to 5 Gy irradiation of intact and immortalized cells, and, on the other side, to demonstrate a great difference in response of immortalized and transformed cells. Cells transformed with the two oncogens E1A and c-Ha-Ras appeared to be much more resistant to ionizing radiation than intact cells and cells immortalized with one oncogene E1A. These data allow to suggest protein p53 tumor-suppressor functioning in transformed cells, but not in intact and immortalized cells.
Kirillova
T V
TV
Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
D017500:Adenovirus E1A Proteins / Q000235:genetics*; D000818:Animals; D002461:Cell Line, Transformed; D002470:Cell Survival / Q000528:radiation effects; D004622:Embryo, Mammalian / Q000166:cytology / Q000528:radiation effects; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays; D011905:Genes, ras; D008938:Mitosis / Q000528:radiation effects*; D051381:Rats
D017500:Adenovirus E1A Proteins
Vliianie ioniziruiushcheĭ radiatsii na mitoticheskiĭ tsikly émbrional'nykh kletok krysy, immortalizovannykh onkogenom E1A i transformirovannykh onkogenami E1A i c-Ha-ras]