[Detection of early cases of Alzheimer's disease. Application of the CERAD neuropsychological test battery].
We attempt to determine the utility of CERAD in detecting early Alzheimer's disease (AD). CERAD battery was administered to a group of 14 control subjects, 12 patients with possible dementia prodromes and to patients with Alzheimer's disease stratified according to severity (16 mild, 8 moderate). Other measures as some subtest of the Wechsler memory scale and the Rey Complex Figure Test were also applied. Delayed recall as well as logical memory of Wechsler memory scale were found to be the best discriminators for detecting very mild cases of AD (Prodromes) (p < 0.05). None of the memory test proved of value in staging the disorder. Visuospatial functions are better determinants of the progression of the illness. Fluency also distinguish between control subjects and very mild cases. These findings suggest that delayed recall memory and probably executive function are the most useful and sensitive indicators of Alzheimer's disease.
Larumbe
R
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Departamento de Neurología y Neurocirugía, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D003704:Dementia / Q000175:diagnosis / Q000523:psychology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests
Detección de casos incipientes de enfermedad de Alzheimer. Aplicación de la batería neuropsicológica CERAD.