Encapsulated islet cells: the role of direct and indirect presentation and the relevance to xenotransplantation and autoimmune recurrence.
Immuno-isolation of islet tissue for the purpose of curing diabetes without immunosuppression is an attractive concept that has been extensively investigated over the last 20 years. Rather than give a detailed review of the past and present history of the immuno-isolation or encapsulation approach for islet transplantation, this paper will examine the concepts behind encapsulation, concentrating on the immune mechanisms involved.
Gray
D W
DW
Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, UK.
D015551:Autoimmunity; D003920:Diabetes Mellitus / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000379:methods*; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous