title: Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni.
abstract: Female mice treated with dehydroepiandrosterone sulfate early during infection were partially protected (P < 0.05-0.005) from Schistosoma mansoni infection. Hormone treatment did not modify parasite-specific cellular or humoral responses. Serum dehydroepiandrosterone sulfate levels and testosterone infection were negatively correlated, r = -0.621 and r = -0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate-treated female mice may be due to the known antischistosomular activity of testosterone.
authors.affiliation: Department of Pathology, University of Cambridge, United Kingdom. pgf@mole.bio.cam.ac.uk
authors.forename: P G
authors.initials: PG
authors.lastname: Fallon
authors.forename: E J
authors.initials: EJ
authors.lastname: Richardson
authors.forename: F M
authors.initials: FM
authors.lastname: Jones
authors.forename: D W
authors.initials: DW
authors.lastname: Dunne
mesh_terms: D000818:Animals; D019314:Dehydroepiandrosterone Sulfate / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000188:drug therapy*
chemical_list: D019314:Dehydroepiandrosterone Sulfate