African origin of GB virus C/hepatitis G virus.
Ninety-four GB virus C/hepatitis G virus (GBV-C/ HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBV-C/HGV.
Tanaka
Y
Y
Second Department of Medicine, Nagoya City University Medical School, Kawasumi, Mizuho, Japan.
Mizokami
M
M
Orito
E
E
Ohba
K
K
Kato
T
T
Kondo
Y
Y
Mboudjeka
I
I
Zekeng
L
L
Kaptue
L
L
Bikandou
B
B
M'Pele
P
P
Takehisa
J
J
Hayami
M
M
Suzuki
Y
Y
Gojobori
T
T
D000349:Africa; D000595:Amino Acid Sequence; D018067:Flaviviridae / Q000737:chemistry* / Q000235:genetics; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D020365:RNA Helicases; D012367:RNA, Viral / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012697:Serine Endopeptidases; D017361:Viral Nonstructural Proteins / Q000235:genetics*; D014764:Viral Proteins / Q000737:chemistry*; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D020365:RNA Helicases; D012367:RNA, Viral; D012697:Serine Endopeptidases; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C060028:NS3 protein, flavivirus; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C096041:NS5 protein, flavivirus