title: HIV infection and SLE: their pathogenic relationship.
abstract: Retroviruses have repeatedly been suggested as a possible trigger mechanism for systemic lupus erythematosus (SLE). We review the role of human immunodeficiency virus (HIV)-1 envelope glycoprotein (gp120) in the induction of immune dysregulation including autoimmunity in HIV-1 infection, and discuss the possible relationship between HIV and SLE in the retroviral etiology.
authors.affiliation: Department of Medicine, Juntendo University, Izu-Nagaoka Hospital, Shizuoka, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Sekigawa
authors.forename: H
authors.initials: H
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Hishikawa
authors.forename: H
authors.initials: H
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Hirose
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
authors.forename: N
authors.initials: N
authors.lastname: Maruyama
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology / Q000821:virology*; D015699:HIV Envelope Protein gp120 / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology / Q000821:virology*; D012192:Retroviridae Infections / Q000150:complications*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D015699:HIV Envelope Protein gp120; D014409:Tumor Necrosis Factor-alpha