title: IGF-1 levels in diabetic pregnant women and their infants.
abstract: Plasma IGF-1 was measured in 38 diabetic pregnant women (DPW) and in 12 non diabetic pregnant women (NDPW) during the 1st, 2nd and 3rd trimester of pregnancy. IGF-1 was measured in the cord blood of 24 infants of diabetic mothers (IDDM) and IGF-1 in 11 infants of non diabetic mothers (NIDDM). A progressive and significant (p < 0.0001) increase of IGF-1 values was found throughout the pregnancy both in DPW and NDPW IGF-1 (149 +/- 18 ng/ml vs 181 +/- 14 ng/ml, 184 +/- 17 ng/ml vs 232 +/- 25 ng/ml, 279 +/- 20 ng/ml vs 325 +/- 17 ng/ml). Furthermore IGF-1 decreased significantly soon after delivery in both groups of women. In type 1 diabetic pregnant women IGF-1 values were significantly lower than the controlled non diabetic patients. IGF-1 in the cord blood was significantly higher in IDDM than in NIDDM 86 +/- 7 ng/ml and 62 +/- 7 ng/ml respectively (p < 0.03). In addition, DPW plasma levels IGF-1 were positively correlated with the weight of the placenta (r = 0.233, p < 0.03) and negatively correlated with the diabetes duration (r = 0.412, p < 0.05). No correlations were found between IGF-1 cord blood concentrations and gestational age, birth weight and length, but there was a significant correlation with weight percentile (r = 0.846, p < 0.001). No correlation was found between maternal IGF-1 plasma levels and other parameters like insulin need, weight gain, metabolic control and time of delivery.
authors.affiliation: Cattedra di Diabetologia, Università degli Studi La Sapienza, Rome, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Di Biase
authors.forename: A
authors.initials: A
authors.lastname: Napoli
authors.forename: S
authors.initials: S
authors.lastname: Caiola
authors.forename: A M
authors.initials: AM
authors.lastname: Buongiorno
authors.forename: E
authors.initials: E
authors.lastname: Maroccia
authors.forename: A
authors.initials: A
authors.lastname: Sabbatini
authors.forename: F
authors.initials: F
authors.lastname: Fallucca
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000276:immunology
chemical_list: D007334:Insulin-Like Growth Factor I