title: IASP diagnostic criteria for complex regional pain syndrome: a preliminary empirical validation study. International Association for the Study of Pain.
abstract: OBJECTIVE
  To assess the ability of the International Association for the Study of Pain Complex Regional Pain Syndrome (CRPS) diagnostic criteria and associated features to discriminate between CRPS patients and patients with painful diabetic neuropathy.
  
  
  METHODS
  Prospective assessment of signs and symptoms in a series of CRPS and diabetic neuropathy patients.
  
  
  METHODS
  University of Washington Multidisciplinary Pain Center.
  
  
  METHODS
  A consecutive series of 18 CRPS patients and 30 diabetic neuropathy patients.
  
  
  METHODS
  Patients completed a 10-item patient history questionnaire assessing symptoms of CRPS prior to medical evaluation. The evaluating physician completed a 10-item patient examination questionnaire assessing objective signs of CRPS.
  
  
  METHODS
  The analyses conducted were designed to test the ability of CRPS signs and symptoms and associated features to discriminate between CRPS patients and diabetic neuropathy patients.
  
  
  RESULTS
  Data analysis suggested that CRPS decision rules may lead to overdiagnosis of the disorder. Diagnosis based on self-reported symptoms can be diagnostically useful in some circumstances. The addition of trophic tissue changes, range of motion changes, and "burning" quality of pain did not improve diagnostic accuracy, but the addition of motor neglect signs did. Test of a CRPS scoring system resulted in improved accuracy relative to current criteria and decision rules.
  
  
  CONCLUSIONS
  Poorly understood disorders lacking prototypical signs/symptoms and diagnostic laboratory testing must rely on the development of reliable diagnostic guidelines. The results of this study should assist in the further refinement of the CRPS diagnostic criteria.
authors.affiliation: Department of Neurology and Anesthesiology, Multidisciplinary Pain Center, University of Washington School of Medicine, Seattle 98105, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: Galer
authors.forename: S
authors.initials: S
authors.lastname: Bruehl
authors.forename: R N
authors.initials: RN
authors.lastname: Harden
mesh_terms: D003929:Diabetic Neuropathies / Q000175:diagnosis; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D006801:Humans; D007391:International Cooperation; D010147:Pain Measurement / Q000379:methods*; D011446:Prospective Studies; D012019:Reflex Sympathetic Dystrophy / Q000175:diagnosis*; D013577:Syndrome