title: Extragonadal germ-cell tumors: a ten-year experience.
abstract: Extragonadal germ-cell tumors (EGCT) are uncommon and biologically distinct from their gonadal counterparts. Thirty-seven patients who had EGCT were treated over a ten-year period at the Regional Cancer Centre, Trivandrum, India. There were 26 men and boys and 11 women and girls. The sites of primary tumor were mediastinum (n=18), central nervous system (n=5), sacrococcygeal region (n=4), retroperitoneum (n=2), and other sites (n=8). After combined modality therapy, 13 of 18 patients who had mediastinal EGCT--1 of 2 with retroperitoneal, 1 of 4 with sacrococcygeal, 0 of 5 with central nervous system, and 2 of 8 patients with tumor in other sites-were alive with no evidence of disease at a median follow-up of 16 months. The overall 5-year survival rate was 40%. Histologic subtype and elevated marker levels were the significant prognostic factors on univariate analysis.
authors.affiliation: Department of Radiotherapy, Regional Cancer Centre, Trivandrum, India.
authors.forename: R
authors.initials: R
authors.lastname: Jacob
authors.forename: K
authors.initials: K
authors.lastname: Ramadas
authors.forename: R
authors.initials: R
authors.lastname: Jyothirmayi
authors.forename: P
authors.initials: P
authors.lastname: Kusumakumary
authors.forename: M K
authors.initials: MK
authors.lastname: Nair
mesh_terms: D000293:Adolescent; D000328:Adult; D016543:Central Nervous System Neoplasms / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D018237:Germinoma / Q000401:mortality / Q000628:therapy; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000401:mortality / Q000628:therapy