title: Increase in Vdelta1+ gammadelta T cells in the peripheral blood and bone marrow as a selective feature of HIV-1 but not other virus infections.
abstract: Dysregulation of T-cell receptor (TCR) alphabeta bearing lymphocytes and an increase in Vdelta1+ gammadelta T cells are typical features of HIV-1 infection. However, the role of gammadelta T cells remains unclear. Therefore, peripheral blood mononuclear cells (PBMC) of 103 HIV-1-infected patients were investigated with respect to expression of Vdelta1. These results were compared to the Vdelta1 expression of bone marrow mononuclear cells (BMMC). In contrast to healthy controls, Vdelta1+ cells dominated among both PBMC and BMMC in HIV-1-infected patients. Analysis of the coexpression of CD25, CD8, HLA-DR and CD45RO revealed a high prevalence of Vdelta1/CD45RO and Vdelta1/HLA-DR double-positive PBMC only in HIV-1-infected patients but not in healthy donors. Furthermore, analysis of the gammadelta TCR repertoire in patients infected with hepatitis B virus, hepatitis C virus, herpes simplex virus (HSV)-1 and HSV-2 showed that the selective enhancement of Vdelta1+ cells was restricted to HIV infection and not observed in other virus diseases. Our data provide further support for the involvement of gammadelta T cells in immunosuppression and progression of HIV infection.
authors.affiliation: Department of Internal Medicine III, University Hospital, Frankfurt, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Rossol
authors.forename: J M
authors.initials: JM
authors.lastname: Dobmeyer
authors.forename: T S
authors.initials: TS
authors.lastname: Dobmeyer
authors.forename: S A
authors.initials: SA
authors.lastname: Klein
authors.forename: S
authors.initials: S
authors.lastname: Rossol
authors.forename: D
authors.initials: D
authors.lastname: Wesch
authors.forename: D
authors.initials: D
authors.lastname: Hoelzer
authors.forename: D
authors.initials: D
authors.lastname: Kabelitz
authors.forename: E B
authors.initials: EB
authors.lastname: Helm
mesh_terms: D000328:Adult; D001854:Bone Marrow Cells / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006684:HLA-DR Antigens / Q000378:metabolism; D006509:Hepatitis B / Q000276:immunology; D006526:Hepatitis C / Q000276:immunology; D006561:Herpes Simplex / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006684:HLA-DR Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta