title: Nitidon, a new bioactive metabolite from the basidiomycete Junghuhnia nitida (Pers.: Fr.) Ryv.
abstract: Nitidon, a highly oxidised pyranone derivative produced by the basidiomycete Junghuhnia nitida, has been isolated and its biological activities evaluated. The structure was determined by spectroscopic methods. Nitidon exhibits antibiotic and cytotoxic activities and induces morphological and physiological differentiation of tumor cells at nanomolar concentrations.
authors.affiliation: Lehrbereich Biotechnologie, Universität Kaiserslautern.
authors.forename: A
authors.initials: A
authors.lastname: Gehrt
authors.forename: G
authors.initials: G
authors.lastname: Erkel
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: O
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D006224:Cricetinae; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D007939:Leukemia L1210 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004852:Epoxy Compounds; C111413:nitidon