Modulation of cutaneous SP receptors in atopic dermatitis after UVA irradiation.
Atopic dermatitis is a pruritic inflammatory skin disorder, involving immunological and non-immunological factors. Substance P seems to be involved in the pathogenesis of atopic dermatitis. Substance P-containing nerve fibers are increased in the lesional skin of patients with atopic dermatitis and a reduced weal and flare reaction to intradermal injection of substance P has been observed. We investigated the distribution of substance P receptors in the involved skin of patients before and after single or repetitive UVA irradiations. Our results indicate that substance P receptors of the NK-1 subtype are expressed on blood vessels and on epidermal keratinocytes of involved skin of patients with atopic dermatitis. UVA irradiations did not modify the epidermal distribution of substance P receptors but decreased their expression intensity on blood vessels. UVA irradiations seem to decrease skin inflammation through the modulation of NK-1 receptor expression on endothelial cells.
Staniek
V
V
INSERM U 346, Pavillon. R, E. Herriot Hospital, Lyon, France.
Liebich
C
C
Vocks
E
E
Odia
S G
SG
Doutremepuich
J D
JD
Ring
J
J
Claudy
A
A
Schmitt
D
D
Misery
L
L
D003876:Dermatitis, Atopic / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy*; D005786:Gene Expression Regulation / Q000528:radiation effects; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism / Q000528:radiation effects; D018040:Receptors, Neurokinin-1 / Q000378:metabolism* / Q000528:radiation effects*; D013373:Substance P / Q000378:metabolism* / Q000528:radiation effects*; D014467:Ultraviolet Therapy
D018040:Receptors, Neurokinin-1; D013373:Substance P