title: Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India.
abstract: Ethanol extract of four different plants of the Khatra region of the Bankura district of West Bengal, India were evaluated for anti-diarrhoeal activity against different experimental models of diarrhoea in rats. The extracts of Ficus bengalensis Linn. (hanging roots), Eugenia jambolana Lam. (bark), Ficus racemosa Linn. (bark) and Leucas lavandulaefolia Rees (aerial parts) showed significant inhibitory activity against castor oil induced diarrhoea and PGE2 induced enteropooling in rats. These extracts also showed a significant reduction in gastrointestinal motility in charcoal meal tests in rats. The results obtained establish the efficacy of all these plant materials as anti-diarrhoeal agents.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta, India.
authors.forename: P K
authors.initials: PK
authors.lastname: Mukherjee
authors.forename: K
authors.initials: K
authors.lastname: Saha
authors.forename: T
authors.initials: T
authors.lastname: Murugesan
authors.forename: S C
authors.initials: SC
authors.lastname: Mandal
authors.forename: M
authors.initials: M
authors.lastname: Pal
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D002368:Castor Oil / Q000009:adverse effects; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D007194:India; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D002368:Castor Oil