Successful use of intravenous immunoglobulins in Landau-Kleffner syndrome.
A detailed history of a boy with Landau-Kleffner syndrome is presented, demonstrating a close relationship between language functioning and paroxysmal electroencephalogram activity. During a 3-year 6-month follow-up period, three abrupt deteriorations of all language functions occurred: the child became totally noninteractive with his environment within 1 week's time. Two of these deteriorations were reversed with steroid treatment, with an identical recovery phase. Intravenous immunoglobulins had a very dramatic and comparable effect in the third relapse; both language functions and electroencephalogram abnormalities were influenced significantly by the intravenous immunoglobulin treatment.
Lagae
L G
LG
University Hospital Gasthuisberg; Department of Pediatrics; Leuven, Belgium.
Silberstein
J
J
Gillis
P L
PL
Casaer
P J
PJ
D002648:Child; D004569:Electroencephalography; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D018887:Landau-Kleffner Syndrome / Q000150:complications / Q000628:therapy*; D007806:Language Disorders / Q000209:etiology / Q000628:therapy; D008297:Male; D009483:Neuropsychological Tests
D016756:Immunoglobulins, Intravenous