title: [Interference of CK-BB isoenzyme in the determination of CK-MB using the immunoinhibition method in patients with pulmonary diseases].
abstract: An increase in serum creatine kinase-MB (CK-MB) isoenzyme is regarded as a specific indicator of acute myocardial infarction. We analyzed retrospectively the clinical data of 94 patients whose serum creatine kinase MB (CK-MB) was measured with immunoinhibition kit which measures all residual CK activity following inactivation of M-subunit. There were 21 patients with chronic obstructive lung disease (COLD), 17 patients with pneumonia, 17 patients with pulmonary tuberculosis (TBC), 16 patients with non-small cell lung cancer (NSCLC), 10 patients with small cell lung cancer (SCLC), 8 patients with malignancies of other origin (NPL), and 5 patients with chronic heart diseases. The results revealed that serum concentrations of CK-MB in SCLC, NSCLC and TBC were significantly greater than those in other groups (P < 0.1). Clinical examination showed no evidence of myocardial infarction, injury, or tumor involvement of the heart. We assumed that those results are due to interference of the CK-BB isoenzyme in the immunoinhibition method. So we suggest that in clinical practice, markedly elevated levels of CK-MB measured with immunoinhibition kit, after the exclusion of the myocardial injury, may point toward the existence of a malignancy or TBC of the lungs.
authors.affiliation: Opća bolnica Dubrovnik, Plućni odjel, Ulica dr. Roka Misetića b.b.
authors.forename: Z
authors.initials: Z
authors.lastname: Vrbica
authors.forename: O
authors.initials: O
authors.lastname: Durović
authors.forename: N
authors.initials: N
authors.lastname: Oreb
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007159:Immunologic Tests; D007527:Isoenzymes; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D003402:Creatine Kinase
vernacular_title: Interferencija izoenzima CK-BB u odredivanju CK-MB metodom imunoinhibichije kod pacijenata s plućnim bolestima.