Epoxide hydrolases: new tools for the synthesis of fine organic chemicals.
Epoxide hydrolases are ubiquitous enzymes able to hydrolyse an epoxide to its corresponding vicinal diol. These hydrolases have been shown often to be highly enantio- and regioselective, thus allowing both the epoxide and the diol to be prepared at high enantiomeric purity. Because these products show high chemical versatility, they are important for the synthesis of various biologically active products. Recent studies have provided valuable information on the molecular structure of these enzymes, as well as insight to the enzymatic mechanisms involved.
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Groupe Biocatalyse et Chimie Fine, CNRS, Université de La Méditerranée, Faculté des Sciences de Luminy, Marseille, France.
Furstoss
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D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis*; D001709:Biotechnology / Q000639:trends*; D004851:Epoxide Hydrolases / Q000737:chemistry*; D006801:Humans; D009930:Organic Chemicals / Q000138:chemical synthesis*
D001688:Biological Products; D009930:Organic Chemicals; D004851:Epoxide Hydrolases