title: A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients.
abstract: Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.
authors.affiliation: Department of Infectious Diseases, Catholic University, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Cauda
authors.forename: M B
authors.initials: MB
authors.lastname: Lucia
authors.forename: L
authors.initials: L
authors.lastname: Ortona
authors.forename: G
authors.initials: G
authors.lastname: Rainaldi
authors.forename: G
authors.initials: G
authors.lastname: Donelli
authors.forename: W
authors.initials: W
authors.lastname: Malorni
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism* / Q000648:ultrastructure; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1