Trace alignment and some of its applications.
BACKGROUND
Extra useful information can be extracted from a DNA chromatogram trace, over that contained in the base-called DNA sequence. Many sequencing applications can benefit from examination of these traces.


RESULTS
An algorithm, based on dynamic programming, for aligning a DNA chromatogram to a DNA sequence is described and implemented. Its applications to vector clipping, EST alignment and mutation detection are discussed.
Mott
R
R
Informatics Group, Sanger Centre, Cambridge, UK.
D000465:Algorithms; D001331:Automation; D004247:DNA; D018076:DNA, Complementary; D008432:Mathematical Computing; D009154:Mutation; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
D018076:DNA, Complementary; D004247:DNA