title: Pharmacokinetics and inflammatory fluid penetration of clinafloxacin.
abstract: A single 200-mg dose of clinafloxacin was given orally to each of nine healthy male volunteers, and the concentrations of the drug were measured in plasma, cantharidin-induced inflammatory fluid, and urine over the following 24 h (48 h in the case of urine). The mean maximum concentration in plasma was 1.34 microg/ml at a mean time of 1.8 h postdose. The mean maximum concentration in the inflammatory fluid was 1.3 microg/ml at 3.8 h postdose. The mean elimination half-life of clinafloxacin in plasma was 5.65 h. The overall penetration into the inflammatory fluid was 93.1%, as assessed by determining the ratio of area under the concentration-time curves. Recovery of clinafloxacin in urine was 58.8% by 24 h and 71.8% by 48 h postdose.
authors.affiliation: Department of Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom. r.wise@bham.ac.uk
authors.forename: R
authors.initials: R
authors.lastname: Wise
authors.forename: S
authors.initials: S
authors.lastname: Jones
authors.forename: I
authors.initials: I
authors.lastname: Das
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002193:Cantharidin; D024841:Fluoroquinolones; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000139:chemically induced; D008297:Male; D015363:Quinolones / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C057477:clinafloxacin; D002193:Cantharidin