Hirunorms, novel hirudin-like direct thrombin inhibitors.
1. Hirunorms are new synthetic peptides designed to interact with thrombin in a similar way to the natural inhibitor hirudin. 2. Hirunorms are specific and efficient in vitro inhibitors of thrombin activity. 3. Hirunorms are potent anticoagulant and antithrombotic agents in in vivo experimental models devoid of hemorrhagic effects at doses that are active in preventing thrombosis.
Cappiello
M
M
Dipartimento di Fisiologia e Biochimica, Università di Pisa, Italy. cmario@dfb.unipi.it
Vilardo
P G
PG
Del Corso
A
A
Mura
U
U
D000991:Antithrombins / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006629:Hirudins / Q000031:analogs & derivatives*; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D013917:Thrombin / Q000037:antagonists & inhibitors*; D013927:Thrombosis / Q000188:drug therapy / Q000517:prevention & control
D000991:Antithrombins; D006629:Hirudins; D010455:Peptides; C102452:hirunorm; C102451:hirunorm IV; D013917:Thrombin