In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants.
The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. Concentrations of 10(6)M to 10(9)M were associated with a dose dependent inhibition of colony formation, with the most clinically important effects seen on the earliest erythroid and granulocyte-macrophage colonies. Because of the potential clinical implications of these observations, studies are needed to determine the effects of dexamethasone on haematopoiesis in preterm infants.
Papoff
P
P
Department of Paediatrics, University of Florida College of Medicine, Gainesville, USA.
Christensen
R D
RD
Harcum
J
J
Li
Y
Y
D000328:Adult; D018929:Cell Culture Techniques; D003114:Colony-Forming Units Assay; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015672:Erythroid Precursor Cells / Q000187:drug effects; D004921:Erythropoietin / Q000494:pharmacology; D005312:Fetal Blood / Q000166:cytology / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*
D005938:Glucocorticoids; D004921:Erythropoietin; C004180:dexamethasone 21-phosphate; D003907:Dexamethasone