title: Influence of human obesity on the metabolic fate of dietary long- and medium-chain triacylglycerols.
abstract: The metabolic fate of an oral long-chain-triacylglycerol (LCT) load and of a mixed oral LCT and medium-chain-triacylglycerol (MCT) load was followed for 6 h in eight control and eight obese subjects with normal postabsorptive triacylglycerol concentrations. Labeled triacylglycerol and indirect calorimetry were used. Results showed that LCTs were less oxidized in obese than in control subjects (3.2+/-0.5 compared with 6.0+/-0.4 g, P < 0.01). Moreover, the amount of LCT oxidized was negatively correlated with fat mass (r = -0.77, P < 0.01). Appearance in plasma of dietary triacyglycerol-derived long-chain fatty acids was blunted in obese subjects and it was negatively related to fat mass (r = -0.84, P < 0.01) and positively to LCT oxidation (r = 0.70, P < 0.01). On the contrary, MCT oxidation was not altered in obese subjects compared with control subjects. Furthermore, the proportion of MCTs oxidized was higher in both groups compared with LCTs (x+/-SEM: 57.5+/-2.6% compared with 15.2+/-1.6%, P < 0.01, n = 16). Our conclusion is that obesity is associated with a defect in the oxidation of dietary LCTs probably related to an excessive uptake by the adipose tissue of meal-derived long-chain fatty acids. MCTs, the oxidation of which is not altered in obesity, could therefore be of interest in the dietary treatment of obesity.
authors.affiliation: Groupement d'Interet Public Centre de Recherche en Nutrition Humaine de Lyon, Hôpital E Herriot, France. binnert@cimac-res.univ-lyon1.fr
authors.forename: C
authors.initials: C
authors.lastname: Binnert
authors.forename: C
authors.initials: C
authors.lastname: Pachiaudi
authors.forename: M
authors.initials: M
authors.lastname: Beylot
authors.forename: D
authors.initials: D
authors.lastname: Hans
authors.forename: J
authors.initials: J
authors.lastname: Vandermander
authors.forename: P
authors.initials: P
authors.lastname: Chantre
authors.forename: J P
authors.initials: JP
authors.lastname: Riou
authors.forename: M
authors.initials: M
authors.lastname: Laville
mesh_terms: D020155:3-Hydroxybutyric Acid; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002153:Calorimetry, Indirect; D002914:Chylomicrons / Q000097:blood; D004041:Dietary Fats / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007328:Insulin / Q000097:blood; D007700:Kinetics; D015227:Lipid Peroxidation; D008079:Lipoproteins, VLDL / Q000097:blood; D009765:Obesity / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D002914:Chylomicrons; D004041:Dietary Fats; D005227:Fatty Acids; D006885:Hydroxybutyrates; D007328:Insulin; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D020155:3-Hydroxybutyric Acid