title: Excellent reliability of nurse-based bedside diagnosis of acute myocardial infarction by rapid dry-strip creatine kinase MB, myoglobin, and troponin T.
abstract: With the aim to compare the diagnostic efficacy as regards acute myocardial infarction of two rapid dry-strip tests, one with both creatine kinase MB (CK-MB) and myoglobin (C + M) and the other with troponin T, and to test the reliability of bedside diagnosis by the coronary care unit (CCU) nurse, 151 patients with acute chest pain admitted to the CCU were investigated. There was no difference in diagnostic performance between rapid tests and quantitative determinations. With <6-hour duration of symptoms, the sensitivity was better for C + M than for troponin T (72% vs 33%, p < 0.05). With symptoms lasting >12 hours on arrival, troponin T performed better, with 100% sensitivity and a negative predictive value of 100% in the 6-hour retest. For exclusion of damage, the two tests have similar and reliable diagnostic capacities 12 hours after the onset of symptoms. The bedside diagnosis or exclusion of acute myocardial infarction was carried out rapidly (within 20 minutes) and reliably by the CCU nurses.
authors.affiliation: Karolinska Institute at the Department of Cardiology, Huddinge University Hospital, Sweden. Christer.Sylven@medhs.ki.se
authors.forename: C
authors.initials: C
authors.lastname: Sylvén
authors.forename: S
authors.initials: S
authors.lastname: Lindahl
authors.forename: K
authors.initials: K
authors.lastname: Hellkvist
authors.forename: O
authors.initials: O
authors.lastname: Nyquist
authors.forename: G
authors.initials: G
authors.lastname: Rasmanis
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003325:Coronary Care Units; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D009211:Myoglobin / Q000097:blood*; D009733:Nursing Diagnosis; D019095:Point-of-Care Systems; D011379:Prognosis; D012372:ROC Curve; D015203:Reproducibility of Results; D013048:Specimen Handling; D014336:Troponin / Q000097:blood*; D020107:Troponin T
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D009211:Myoglobin; D014336:Troponin; D020107:Troponin T; D003402:Creatine Kinase