Repair and processing events at DNA ends.
Cell nuclei contain several abundant enzymes that bind rapidly and avidly to exposed termini of DNA. The properties and physiological roles of such factors are described; they include poly (ADP-ribose) polymerase, DNA-dependent protein kinase, several DNA ligases and excision-repair enzymes. Telomeres normally seem shielded from these activities by telomere-binding proteins. If incomplete protection of telomeres occurred, the functions of the DNA end-specific enzymes would be relevant for processing of telomeres. This could include alternative pathways for telomere propagation in telomerase-negative cells.
Lindahl
T
T
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK.
Barnes
D E
DE
Klungland
A
A
Mackenney
V J
VJ
Schär
P
P
D004247:DNA / Q000378:metabolism*; D011088:DNA Ligases / Q000378:metabolism; D004260:DNA Repair; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D009711:Nucleotides / Q000378:metabolism; D011064:Poly Adenosine Diphosphate Ribose / Q000096:biosynthesis; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
D004268:DNA-Binding Proteins; D009711:Nucleotides; D011064:Poly Adenosine Diphosphate Ribose; D004247:DNA; D011065:Poly(ADP-ribose) Polymerases; D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases; D011088:DNA Ligases