title: Amlexanox oral paste: a novel treatment that accelerates the healing of aphthous ulcers.
abstract: Five percent Amlexanox oral paste is a novel treatment for aphthous ulcers. In 3 controlled clinical studies that evaluated 1,124 immunocompetent patients with mild to moderate aphthous ulcers, 5% Amlexanox oral paste (Aphthasol) was shown to accelerate healing of these ulcers. Treatment with Aphthasol reduced the median time to ulcer healing and to complete pain resolution in a statistically significant manner. This was true both when treatment with 5% Amlexanox oral paste was compared to treatment with a vehicle and when treatment with the Amlexanox paste was compared to no treatment. Study results after 3 days comparing treatment with the paste and no treatment indicated complete healing of ulcers for 21% and 8% of patients, respectively. Complete resolution of pain after 3 days was reported for 44% and 20% of patients, respectively.
authors.affiliation: Department of Diagnostic Sciences, Baylor College of Dentistry, Texas A&M University System, Dallas, USA.
authors.forename: W H
authors.initials: WH
authors.lastname: Binnie
authors.forename: F A
authors.initials: FA
authors.lastname: Curro
authors.forename: A
authors.initials: A
authors.lastname: Khandwala
authors.forename: R G
authors.initials: RG
authors.lastname: Van Inwegan
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000631:Aminopyridines / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D010147:Pain Measurement; D013281:Stomatitis, Aphthous / Q000188:drug therapy*
chemical_list: D000631:Aminopyridines; D000893:Anti-Inflammatory Agents; C045742:amlexanox