title: Soluble intercellular adhesion molecule-1 serum profile in physiologic and preeclamptic pregnancy.
abstract: OBJECTIVE
  The aim of this study was to determine serum levels of soluble intercellular adhesion molecule (sICAM)-1, an adhesion receptor that mediates interactions with the immune system, in physiologic and preeclamptic pregnancies. Moreover, we evaluated whether the release of sICAM-1 during pregnancy correlated to plasma fibronectin concentrations.
  
  
  METHODS
  Serum was collected from 18 nonpregnant, control women, from 58 normal pregnant women during the first (n = 13), second (n = 15), and third (n = 30) trimesters, and from 25 preeclamptic patients at 27-39 weeks' gestation. All samples were assayed for sICAM-1 by a specific enzyme-linked immunoassay and for fibronectin by a nephelometric system. Serum sICAM-1 levels in preeclamptic patients were compared to those obtained from gestational-matched normal pregnant women.
  
  
  RESULTS
  Levels of sICAM-1 were significantly elevated (P < 0.001) in each of the three trimesters of normal pregnancy (I trimester: 390.4 +/- 25.7 ng/ml; II trimester: 386.3 +/- 15.4 ng/ml; and III trimester: 367.3 +/- 15.8 ng/ml) when compared to those of healthy nonpregnant women (263.3 +/- 11.6 ng/ml). No significant difference in sICAM-1 concentrations was observed among the three trimesters. Preeclampsia was associated to a significant decrease (P < 0.01) of sICAM-1 levels (309.8 +/- 11.6 ng/ml) relative to those observed in gestational-matched pregnant women (367.3 +/- 15.8 ng/ml). Fibronectin and sICAM-1 levels did not correlate.
  
  
  CONCLUSIONS
  The increased levels of sICAM-1 found in physiologic pregnancies and its reduction in preeclampsia may account for some of the immunologic alterations demonstrated to be associated with pregnancy.
authors.affiliation: II Dept. of Obstetrics and Gynecology, Clinica L. Mangiagalli, University of Milano, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Airoldi
authors.forename: B
authors.initials: B
authors.lastname: Gaffuri
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: E
authors.initials: E
authors.lastname: Iurlaro
authors.forename: A
authors.initials: A
authors.lastname: Nozza
authors.forename: P
authors.initials: P
authors.lastname: Viganò
authors.forename: M
authors.initials: M
authors.lastname: Vignali
mesh_terms: D000328:Adult; D005260:Female; D005353:Fibronectins / Q000097:blood; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D012016:Reference Values; D012995:Solubility
chemical_list: D005353:Fibronectins; D018799:Intercellular Adhesion Molecule-1