Personality correlates of +/- pindolol induced decreases in prolactin.
The present study was conducted to investigate if personality traits can be usefully related to serotonergic vs. dopaminergic action of the 5-HT1a-antagonist +/- pindolol. Forty healthy male volunteers (aged between 20 and 30 years) were randomly assigned to a placebo or a +/- pindolol (30 mg, oral dose) group in a double blind trial. Blood samples were drawn and analyzed for PRL concentrations. In addition, the subjects completed questionnaires on personality. The results indicated that +/- pindolol decreases PRL concentrations depending on personality. While subjects high on impulsivity and related traits (aggression and disinhibition) show lower PRL decreases, well-being and personality traits frequently related to dopaminergic activity were not correlated with changes in PRL. Since reduced (blunted) PRL-responses after 5-HT challenge tests have been reported for impulsives, the present results favor the involvement of primarily serotonergic and probably only secondarily dopaminergic control of +/- pindolol induced PRL decreases.
Hennig
J
J
Department of Psychology, University of Giessen, FRG.
Kroeger
A
A
Meyer
B
B
Prochaska
H
H
Krien
P
P
Huwe
S
S
Netter
P
P
D000319:Adrenergic beta-Antagonists / Q000737:chemistry / Q000494:pharmacology*; D000328:Adult; D000374:Aggression / Q000187:drug effects / Q000502:physiology; D004644:Emotions / Q000187:drug effects; D006801:Humans; D007175:Impulsive Behavior; D008297:Male; D010551:Personality / Q000187:drug effects*; D010556:Personality Tests; D010869:Pindolol / Q000737:chemistry / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D012702:Serotonin Antagonists / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
D000319:Adrenergic beta-Antagonists; D012702:Serotonin Antagonists; D011388:Prolactin; D010869:Pindolol