title: Merkel cell carcinoma: report of three cases.
abstract: Three cases of Merkel cell carcinoma are reported: Case 1 on the upper eyelid with regional lymph node metastasis, Case 2 with spontaneous regression after repeated biopsies, and Case 3 presumably developing on the lesion of pre-existing Bowen's disease. In Case 2, the biopsy specimen was characterized by numerous apoptotic cells in the periphery of the tumor nests surrounded by lymphocytic infiltration. In Case 3, the tumor developed after injury to the pre-existing lesion of Bowen's disease.
authors.affiliation: Department of Dermatology, Oita Medical University, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Okamoto
authors.forename: M
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: S
authors.initials: S
authors.lastname: Takayasu
authors.forename: S
authors.initials: S
authors.lastname: Yokoyama
mesh_terms: D000368:Aged; D017209:Apoptosis; D001706:Biopsy; D001913:Bowen's Disease / Q000473:pathology / Q000601:surgery; D015266:Carcinoma, Merkel Cell / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D002467:Cell Nucleus / Q000648:ultrastructure; D002610:Cheek / Q000473:pathology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005142:Eyelid Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005153:Facial Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009365:Neoplasm Regression, Spontaneous; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012074:Remission Induction; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery
chemical_list: D010751:Phosphopyruvate Hydratase