A new, striking morphological alteration of P-glycoprotein expression in NK cells from AIDS patients.
Natural killer cells from healthy donors express P-glycoprotein on their surface. This molecule is rearranged during the process of cell-mediated cytotoxicity and it appears to be clustered in the cell-to-cell contact regions. By contrast, in HIV-infected subjects this rearrangement is hindered. These results seem to be associated with cytoskeleton network alterations of the cell-mediated killing process occurring in AIDS patients and can contribute to the comprehension of the mechanisms of the natural killer cell deficiency found in these patients.
Cauda
R
R
Department of Infectious Diseases, Catholic University, Rome, Italy.
Lucia
M B
MB
Ortona
L
L
Rainaldi
G
G
Donelli
G
G
Malorni
W
W
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism* / Q000648:ultrastructure; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D014407:Tumor Cells, Cultured
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1