title: Superior sagittal sinus thrombosis associated with primary antiphospholipid syndrome--case report.
abstract: A 36-year-old female with a history of recurrent pregnancy loss experienced sudden onset of disturbance in consciousness, with right hemiparesis and total aphasia. Computed tomography revealed a massive hemorrhage in the left frontal lobe, and angiography showed occlusion of the anterior two-thirds of the superior sagittal sinus. Laboratory investigations detected the presence of lupus anticoagulant, elevation of the anticardiolipin beta 2-glycoprotein I complex antibody level, and a decreased protein S activity level. There were no underlying conditions, such as connective tissue disorders, malignancies, infectious diseases, and drug-induced disorders, so the diagnosis was primary antiphospholipid syndrome. Primary antiphospholipid syndrome should be considered in the evaluation of patients with "idiopathic" or "primary" sinus and cerebral venous thrombosis.
authors.affiliation: Department of Neurosurgery, Saiseikai Toyama Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nagai
authors.forename: Y
authors.initials: Y
authors.lastname: Horie
authors.forename: T
authors.initials: T
authors.lastname: Akai
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: A
authors.initials: A
authors.lastname: Takaku
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002533:Cerebral Angiography; D003392:Cranial Sinuses; D005260:Female; D006801:Humans; D011247:Pregnancy; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed