title: The mannose receptor is a pattern recognition receptor involved in host defense.
abstract: The mannose receptor recognizes the patterns of carbohydrates that decorate the surfaces and cell walls of infectious agents. This macrophage and dendritic cell pattern-recognition receptor mediates endocytosis and phagocytosis. The mannose receptor is the prototype of a new family of multilectin receptor proteins (membrane-spanning receptors containing eight-ten lectin-like domains, which appear to play a key role in host defense) and provides a link between innate and adaptive immunity. Recent advances include the identification of three new members of the mannose receptor family, additional work on defining the molecular requirements for sugar binding, a role for the mannose receptor in antigen presentation of lipoglycan antigens and evidence that the mannose receptor is associated with a signal transduction pathway leading to cytokine production.
authors.affiliation: Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. pstahl@cellbio.wastl.edu
authors.forename: P D
authors.initials: PD
authors.lastname: Stahl
authors.forename: R A
authors.initials: RA
authors.lastname: Ezekowitz
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D008358:Mannose / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*
chemical_list: D011956:Receptors, Cell Surface; D008358:Mannose