title: [The plasma level of the neurotoxin 1-trichloromethyl-1,2,4,5-tetrahydro-beta-carboline (TaClo) in man after oral administration of chloral hydrate].
abstract: Chloral hydrate (CAS 302-17-0) is a widely used hypnotic and sedative agent. It was recently reported in the literature that a neurotoxin, TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline), may be formed in vitro from tryptamine (Ta) and chloral (Clo). Intraperitoneal administration of TaClo led to parkinson-like symptoms in the rat. Hence, the plasma levels of TaClo were determined at various time-points in 18 healthy volunteers in two periods each during a bioavailability study of several chloral hydrate preparations. The limit of quantitation for TaClo was 5 ng/ml. No TaClo could be determined in the plasma of the various volunteers following administration of human therapeutic doses of chloral hydrate. Hence, it is unlikely that TaClo will be formed in man after application of therapeutic doses of chloral hydrate to patients.
authors.affiliation: LPT Laboratory of Pharmacology and Toxicology, Hamburg.
authors.forename: J
authors.initials: J
authors.lastname: Leuschner
authors.forename: N
authors.initials: N
authors.lastname: Beuscher
authors.forename: T
authors.initials: T
authors.lastname: Zimmermann
authors.forename: M
authors.initials: M
authors.lastname: Schürer
authors.forename: H U
authors.initials: HU
authors.lastname: Schulz
authors.forename: J
authors.initials: J
authors.lastname: Jeromin
authors.forename: H
authors.initials: H
authors.lastname: Ritter
mesh_terms: D000328:Adult; D002243:Carbolines / Q000097:blood*; D002697:Chloral Hydrate / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D009498:Neurotoxins / Q000097:blood*; D013055:Spectrophotometry, Infrared
chemical_list: D002243:Carbolines; D006993:Hypnotics and Sedatives; D009498:Neurotoxins; C067372:1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline; D002697:Chloral Hydrate
vernacular_title: Untersuchungen zu Plasmaspiegeln des Neurotoxins 1-Trichlormethyl-1,2,3,4-tetrahydro-beta-carbolin (TaClo) beim Menschen nach oraler Verabreichung von Chloralhydrat.