Antimicrobial resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995.
Three hundred and thirty-three Shigella isolates obtained in 1986 to 1995 were tested for their susceptibilities to 19 antimicrobial agents. Nalidixic acid resistance had emerged in 59.6% of Shigella flexneri isolates during 1994 to 1995, with all tested resistant isolates having the mutation in gyrA encoding the Ser-83 alteration. Multiresistance (resistance to four or more agents) was more common in S. flexneri than in Shigella sonnei.
Chu
Y W
YW
Department of Microbiology, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories.
Houang
E T
ET
Lyon
D J
DJ
Ling
J M
JM
Ng
T K
TK
Cheng
A F
AF
D000890:Anti-Infective Agents / Q000494:pharmacology*; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics; D006723:Hong Kong; D006801:Humans; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology*; D012763:Shigella flexneri / Q000187:drug effects* / Q000235:genetics; D012764:Shigella sonnei / Q000187:drug effects* / Q000235:genetics
D000890:Anti-Infective Agents; D009268:Nalidixic Acid; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II