(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.
Forbes
I T
IT
Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex, England.
Dabbs
S
S
Duckworth
D M
DM
Jennings
A J
AJ
King
F D
FD
Lovell
P J
PJ
Brown
A M
AM
Collin
L
L
Hagan
J J
JJ
Middlemiss
D N
DN
Riley
G J
GJ
Thomas
D R
DR
Upton
N
N
D000262:Adenylyl Cyclases / Q000378:metabolism; D001667:Binding, Competitive; D002460:Cell Line; D015870:Gene Expression; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology; D000096926:Benzenesulfonamides
D000262:Adenylyl Cyclases; D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013449:Sulfonamides; C111309:3,N-dimethyl-N-(1-methyl-3-(4-methylpiperidin-1-yl)propyl)benzenesulfonamide; D000096926:Benzenesulfonamides; C104425:serotonin 7 receptor