title: Ciprofloxacin overdose: acute renal failure with prominent apoptotic changes.
abstract: Acute renal failure due to ciprofloxacin has been well described. The previously reported cases have been consistent both clinically and pathologically with tubulointerstitial nephritis (TIN). We report a case of ciprofloxacin overdose leading to acute renal failure characterized by acute tubular necrosis (ATN). The outstanding features in the patient's renal biopsy were those of distal nephron apoptosis, best seen in plastic-embedded sections and electron microscopy. This report shows that the distal nephron can be singularly involved in acute renal failure and that electron microscopy or plastic-embedded sections may be necessary to define its involvement.
authors.affiliation: Division of Nephrology, Children's Hospital, Boston, MA 02115, USA. dharnidharka@a1.tch.harvard.edu
authors.forename: V R
authors.initials: VR
authors.lastname: Dharnidharka
authors.forename: K
authors.initials: K
authors.lastname: Nadeau
authors.forename: C L
authors.initials: CL
authors.lastname: Cannon
authors.forename: H W
authors.initials: HW
authors.lastname: Harris
authors.forename: S
authors.initials: S
authors.lastname: Rosen
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000293:Adolescent; D000890:Anti-Infective Agents / Q000009:adverse effects*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects; D017209:Apoptosis / Q000187:drug effects*; D001706:Biopsy; D002939:Ciprofloxacin / Q000009:adverse effects*; D062787:Drug Overdose / Q000473:pathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000648:ultrastructure; D014196:Trazodone / Q000009:adverse effects
chemical_list: D000890:Anti-Infective Agents; D018687:Antidepressive Agents, Second-Generation; D002939:Ciprofloxacin; D014196:Trazodone