[The effect of immunomodulators on the development of antibodies to the diphtheria antigen in mice vaccinated with the DTP adsorbed vaccine].
An animal model for the study of the influence of immunomodulators on the development and preservation of postvaccinal antidiphtheria immunity was experimentally selected and the corresponding study was carried out. In this work the following immunomodulators were used: dibasol, prodigiosan, splenin, thymalin, reaferon, tactivin, methyluracyl. The study revealed that by day 120 of observation all immunomodulators stimulated the production of antibodies in higher titers than adsorbed DPT vaccine, introduced without immunomodulators. The most effective action was exhibited by splenin and prodigiosan (injected subcutaneously), dibasol and methyluracyl (administered orally). Two latter immunomodulators, if introduced prior to immunization, are the most promising preparations to be used in practical immunoprophylaxis.
Chudnaia
L M
LM
Gromashevsky Institute of Epidemiology and Infectious Diseases, Kiev, Ukraine.
Frolov
A F
AF
Oksiiuk
V G
VG
Krasiuk
L S
LS
Moroz
L V
LV
Afanas'eva
S M
SM
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000187:drug effects*; D000942:Antigens, Bacterial / Q000276:immunology*; D003353:Corynebacterium diphtheriae / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D013268:Stimulation, Chemical; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine
Vliianie immunomoduliatorov na vyrabotku antitel k difteriĭnomu antigenu u mysheĭ, vaktsinirovannykh AKDS-vaktsinoĭ.