title: Mapping of 22 new ESTs around a tumor suppressor gene and a senescence gene at 6q16-->q21.
abstract: Twenty two expressed sequence tags (ESTs) have been mapped at the border of 6q16-->q21 and at the proximal end of 6q21, a candidate for two tumor suppressor genes and a senescence gene. Use of a translocation and deletion hybrid panel together with a 4-Mb YAC contig allowed us to precisely define the position of the ESTs. Thirteen ESTs were placed within the 4-Mb interval at the proximal portion of 6q21 using a restriction map of the YAC contig, seven ESTs span a 2-Mb region on the 6q16-->q21 border, and two are distal to the contig. Refinement of the localization of these ESTs will provide substantial assistance in identifying new genes within the region 6q16-->q21.
authors.affiliation: Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Morelli
authors.forename: F
authors.initials: F
authors.lastname: Cardona
authors.forename: J M
authors.initials: JM
authors.lastname: Boyle
authors.forename: M
authors.initials: M
authors.lastname: Negrini
authors.forename: G
authors.initials: G
authors.lastname: Barbanti-Brodano
mesh_terms: D000375:Aging / Q000235:genetics*; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002896:Chromosomes, Human, Pair 6; D017931:DNA Primers; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D014178:Translocation, Genetic
chemical_list: D017931:DNA Primers; D005819:Genetic Markers