Mucosal blood flow during various intravenous and inhalational anesthetics in the rabbit.
OBJECTIVE
The goal of this study was to compare the effects of nitrous oxide (N2O), isoflurane (ISO), fentanyl (FENT), and propofol (PROP) on the tongue mucosal blood flow (TMBF) in rabbits.


METHODS
TMBF was measured with a laser Doppler flow meter before and after the administration of 50% N2O (n = 7), 1.0 and 1.5 minimum alveolar concentration ISO (n = 6), 10, 20, and 40 micrograms/kg FENT (n = 8) or 100, 200 and 400 micrograms/kg/min PROP (n = 7). Hemodynamic variables including heart rate, systolic blood pressure (SBP), mean arterial pressure (MAP) and aortic blood flow (AoF) were continuously monitored. Total peripheral resistance (TPR) was calculated as MAP divided by AoF.


RESULTS
An increase in TMBF along with reductions in SBP, MAP and TPR were observed in ISO group. In FENT group, TMBF was decreased, whereas other hemodynamic variables showed no change. TMBF in groups N2O and PROP did not change.


CONCLUSIONS
These results indicate that TMBF depends on the anesthetic used.
Ichinohe
T
T
Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan.
Homma
Y
Y
Kaneko
Y
Y
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D005283:Fentanyl / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000494:pharmacology; D017078:Laser-Doppler Flowmetry; D008297:Male; D009061:Mouth Mucosa / Q000098:blood supply / Q000187:drug effects; D009609:Nitrous Oxide / Q000494:pharmacology; D015742:Propofol / Q000494:pharmacology; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013599:Systole; D014059:Tongue / Q000098:blood supply* / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007530:Isoflurane; D009609:Nitrous Oxide; D005283:Fentanyl; D015742:Propofol