title: D-erythrulose reductase can also reduce diacetyl: further purification and characterization of D-erythrulose reductase from chicken liver.
abstract: We have discovered new characteristics of D-erythrulose reductase, namely, that it can catalyze reduction of not only D-erythrulose but also such diketones as diacetyl. These substrates have a common structure with two neighboring carbonyls possibly in s-cis plane structure, showing that the enzyme may rigorously distinguish between substrates and other compounds. D-Erythrulose reductase was predominantly located in the kidney and the liver of the chicken. The obtained results suggest that D-erythrulose reductase plays an important role in metabolizing alpha-dicarbonyls in animal organs, because these diketones widely occur in natural foods.
authors.affiliation: Faculty of Pharmaceutical Sciences, Osaka University, Yamada-oka, Suita, Osaka 565-0871.
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: S
authors.initials: S
authors.lastname: Hosomi
authors.forename: T
authors.initials: T
authors.lastname: Mizoguchi
authors.forename: T
authors.initials: T
authors.lastname: Nishihara
mesh_terms: D000818:Animals; D002645:Chickens; D002853:Chromatography, Liquid; D003931:Diacetyl / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D010084:Oxidation-Reduction; D013379:Substrate Specificity; D013401:Sugar Alcohol Dehydrogenases / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D013401:Sugar Alcohol Dehydrogenases; C020117:D-erythrulose reductase; D003931:Diacetyl