title: Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.
abstract: The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the epsilon4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE . Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.
authors.affiliation: Centre for Research in Neurodegenerative Diseases, Department of Medicine (Division of Neurology), University of Toronto, Toronto, Ontario, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Brindle
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.forename: E
authors.initials: E
authors.lastname: Rogaeva
authors.forename: S
authors.initials: S
authors.lastname: Premkumar
authors.forename: G
authors.initials: G
authors.lastname: Levesque
authors.forename: G
authors.initials: G
authors.lastname: Yu
authors.forename: M
authors.initials: M
authors.lastname: Ikeda
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: A
authors.initials: A
authors.lastname: Paterson
authors.forename: S
authors.initials: S
authors.lastname: Sorbi
authors.forename: R
authors.initials: R
authors.lastname: Duara
authors.forename: L
authors.initials: L
authors.lastname: Farrer
authors.forename: P
authors.initials: P
authors.lastname: St George-Hyslop
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D002091:Butyrylcholinesterase / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D005819:Genetic Markers; D002091:Butyrylcholinesterase