Effects of intrathecally administered aminoglycoside antibiotics, calcium-channel blockers, nickel and calcium on acetic acid-induced writhing test in mice.
1. Antinociceptive effects of intrathecally administered aminoglycoside antibiotics, calcium-channel blockers, nickel and calcium ions on the acetic acid-induced writhing test in mice were examined. 2. Neomycin (0.5-20.0 micrograms/mouse) gentamicin (5-40 micrograms/mouse), nicardipine, diltiazem and verapamil (0.5-80.0 micrograms/mouse) and calcium ions (0.02-1.0 mumol/mouse) exerted a dose-dependent antinociceptive activity on the acetic acid-induced writhing test. Nickel ions (2.5, 5.0 and 10.0 mumol/mouse) were found ineffective in this test. 3. These results suggest that N- and L-type, but not T-type, voltage-dependent calcium channels are implicated in the spinal processing of nociceptive information.
Doğrul
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Department of Pharmacology, Faculty of Medicine, Gülhane Medical Military Academy, Etlik, Ankara, Turkey.
Yeşilyurt
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O
D019342:Acetic Acid / Q000009:adverse effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D051379:Mice; D009355:Neomycin / Q000494:pharmacology*; D009532:Nickel / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced; D010147:Pain Measurement / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002121:Calcium Channel Blockers; D005839:Gentamicins; D009532:Nickel; D009355:Neomycin; D019342:Acetic Acid; D002118:Calcium