title: Novel site-specific DNA endonucleases.
abstract: Site-specific hydrolysis of DNA is common to many biological processes. Three new structures, FokI, I-CreI and PI-SceI, were reported in the past year, providing the first view of type IIs endonucleases and homing endonucleases. Together, they reveal an extraordinary set of new mechanisms by which endonucleases target the hydrolysis of specific DNA sequences.
authors.affiliation: Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA. Aggarwal@inka.mssm.edu
authors.forename: A K
authors.initials: AK
authors.lastname: Aggarwal
authors.forename: D A
authors.initials: DA
authors.lastname: Wah
mesh_terms: D000595:Amino Acid Sequence; D001482:Base Composition; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D004262:DNA Restriction Enzymes / Q000737:chemistry* / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000737:chemistry* / Q000378:metabolism; D019281:Dimerization; D004706:Endodeoxyribonucleases / Q000737:chemistry* / Q000378:metabolism; D019077:Helix-Turn-Helix Motifs; D008958:Models, Molecular; D011487:Protein Conformation; D006180:Proton-Translocating ATPases; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D029701:Saccharomyces cerevisiae Proteins; D004247:DNA; D004706:Endodeoxyribonucleases; D004262:DNA Restriction Enzymes; C048901:endodeoxyribonuclease CreI; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific; D006180:Proton-Translocating ATPases; C081687:VMA1 protein, S cerevisiae