title: Lack of association between schizophrenia and HLA DQB1 alleles in a Swedish sample.
abstract: Three studies have reported a negative genetic association between schizophrenia and HLA DQB1*0602, an allele of the human leucocyte antigen (HLA) DQB1*06 gene. In a sample of ethnic all homogeneous Caucasians living in Sweden, the frequency of HLA DQB1 alleles in patients with schizophrenia (n = 124) was compared with that in a control group (n = 85). No significant differences were found. Together with previous investigations, the present study indicates that the reported genetic association of DQB1*0602 with schizophrenia may be limited to non-Caucasians.
authors.affiliation: Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden.
authors.forename: E G
authors.initials: EG
authors.lastname: Jönsson
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: V L
authors.initials: VL
authors.lastname: Nimgaonkar
authors.forename: W A
authors.initials: WA
authors.lastname: Rudert
authors.forename: G C
authors.initials: GC
authors.lastname: Sedvall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D013548:Sweden
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen