title: Algorithms for computerized QT analysis.
abstract: Several methods for measurement of the offset, peak, and morphology of the T wave in multilead ECGs are reviewed and compared. The T wave offset is the most important and also the most difficult measurement for analysis of QT interval dispersion. Measurement methods compared here include (1) the point at which the T wave intersects the isoelectric line plus a threshold; (2) the point at which the derivative of T wave intersects the isoelectric line plus a threshold; (3) the intersection of the maximum slope of the T wave and the isoelectric line; (4) the intersection of a line fitted by least squares to the maximum slope of the T wave and an isoelectric line (LSI); and (5) the point at which the T wave area reaches 90% of the entire T wave area (TA). The reproducibility tests show that the LSI method has the best reproducibility of all the algorithms examined. Although the T wave peak is better defined than the T wave offset, it is not simple to find the right peak when there are multiple T wave peaks and when the T wave is flat and/or noisy. Methods to find T wave patterns with multiple peaks and to locate the point at which the T wave is flat and noisy are therefore reviewed here. Finally, the principal component analysis-based T wave complexity measurement and its relation to other QT interval dispersion measurements are discussed.
authors.affiliation: Marquette Medical Systems, Inc., Milwaukee, Wisconsin 53223, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Xue
authors.forename: S
authors.initials: S
authors.lastname: Reddy
mesh_terms: D000465:Algorithms; D004562:Electrocardiography; D004594:Electrophysiology; D006321:Heart / Q000502:physiology; D006801:Humans; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted