Donor factors affecting outcome after pancreas transplantation.
In this study, we demonstrated that Px grafts from donors older than 45 years are associated with an increased risk of developing poor glycemic control and premature loss of Px function. Previous studies corroborate our finding that age of the donor is the principal donor characteristic impacting postoperative Px survival. Whereas prior studies also implicated hyperamylasemia as a factor which contributes adversely to outcome, we were unable to demonstrate a significant influence of donor hyperamylasemia on long-term graft survival, although it did correlate with the degree of immediate postoperative pancreatitis and with the need for oral hypoglycemic agents. Similarly, elevated blood glucoses in the donor, which can be a result of many other factors unrelated to the quality of the graft, did not predict a poor outcome in the recipient. NHB donor pancreata did as well as HB pancreata with regards to all postoperative functional parameters. A marginally increased risk of developing major complications was associated with older donors. Despite the frequent use of non-ideal donors, including older and NHB donors, excellent overall Px graft survival can be achieved. Although the quality of the pancreas graft was not directly addressed in this study, we believe irrespective of hyperglycemia or hyperamylasemia, subjective assessment of organ quality by an experienced transplant surgeon is the most important determinant of suitability.
Odorico
J S
JS
Department of Surgery, University of Wisconsin Hospital and Clinics, Madison, USA.
Heisey
D M
DM
Voss
B J
BJ
Steiner
D S
DS
Knechtle
S J
SJ
D'Alessandro
A M
AM
Hoffmann
R M
RM
Sollinger
H W
HW
D000328:Adult; D000367:Age Factors; D002102:Cadaver; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D015999:Multivariate Analysis; D016035:Pancreas Transplantation; D012307:Risk Factors; D014019:Tissue Donors