Response of serum indicators of myocardial infarction following exercise-induced muscle injury.
The purpose of this investigation was to determine the response of three parameters used in the assessment of acute myocardial infarction (AMI) after a single bout of eccentric exercise designed to elicit skeletal muscle injury. Total creatine kinase (CK), CK-MB isoenzyme (CK-MB), and the leukocyte differential were determined after a 20-minute bench-stepping exercise in 21 men ranging in age from 30 to 45 years. Comparison of several criteria showed that the use of CK-MB or the relative lymphocyte percentage alone resulted in 11% and 1.8%, respectively, of data collection points exceeding cutoff values suggestive of AMI. However, the use of both parameters in combination completely eliminated false-positive results with no data collection points meeting the criterion. It is thus suggested that CK-MB activity in conjunction with the relative lymphocyte percentage may not only provide incremental value in the detection of AMI but also reduce the incidence of misdiagnosis associated with exercise.
Hayward
R
R
Human Performance Laboratory, University of Arkansas, Fayetteville, USA.
Balog
J M
JM
Schneider
C M
CM
D000328:Adult; D000704:Analysis of Variance; D003402:Creatine Kinase / Q000097:blood*; D003937:Diagnosis, Differential; D005080:Exercise Test; D005189:False Positive Reactions; D006801:Humans; D015994:Incidence; D007527:Isoenzymes; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology; D005082:Physical Exertion / Q000502:physiology*; D013997:Time Factors
D007527:Isoenzymes; D003402:Creatine Kinase