title: Association between female sex hormones and biochemical markers of bone turnover in peri- and postmenopausal women.
abstract: In an epidemiological study, markers of bone formation (serum osteocalcin and C-terminal propeptide of type I collagen) and bone resorption [urinary type I collagen peptides (Crosslaps), urinary total pyridinoline (TPYRI), urinary deoxypyridinoline (DPYRI) as well as female sex hormones (serum estradiol)], follicle-stimulating hormone (FSH) and luteinizing hormone were measured in 237 women. This cohort aged 44-66 years, came for their first medical examination since menopause to the outpatient menopause clinic at the Kaiser-Franz-Josef-Hospital, Vienna. The women were all 0.5-5.0 years since cessation of menses and were not taking medications other than hormone replacement therapy [52 cases, 21.9%)] and had no diseases known to affect bone and mineral metabolism. The best correlation was found between urinary DPYRI and urinary TPYRI (r = 0. 63, P = 0.0001), followed by urinary Crosslaps and urinary DPYRI (r = 0.47, p = 0.0001). Only weak but significant correlations between E2 and urinary Crosslaps (r = -0.21, P < 0.0001) as well as serum E2 and serum osteocalcin (r = -0.16, P = 0.0007), were observed. Of the 237 women 53% suffered from a severe E2 deficiency (E2 < 10.0 ng/liter). In these patients, urinary Crosslaps (+48%) and serum osteocalcin (+22%) were significantly higher (P < 0.0001) compared with those patients with E2 levels > 10 ng/liter. Women with E2 levels >10 ng/liter were further subdivided into those with and without sex hormone replacement therapy, whereby no statistical differences in any of the biochemical markers could be observed between these groups. We could clearly demonstrate that in postmenopausal women suffering from severe E2 deficiency (E2 < 10 ng/liter), urinary Crosslaps and serum osteocalcin are significantly increased, indicating in principle a clear correlation between E2 deficiency and these markers of bone turnover.
authors.affiliation: 2nd Department of Internal Medicine, Rheumatology, and Osteology, Kaiser-Franz-Josef-Hospital, Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Peichl
authors.forename: A
authors.initials: A
authors.lastname: Griesmacher
authors.forename: P
authors.initials: P
authors.lastname: Pointinger
authors.forename: R
authors.initials: R
authors.lastname: Marteau
authors.forename: W
authors.initials: W
authors.lastname: Hartl
authors.forename: W
authors.initials: W
authors.lastname: Gruber
authors.forename: H
authors.initials: H
authors.lastname: Bröll
mesh_terms: D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood* / Q000652:urine*; D001862:Bone Resorption / Q000453:epidemiology; D001842:Bone and Bones / Q000502:physiology*; D015331:Cohort Studies; D003094:Collagen / Q000097:blood / Q000652:urine; D004958:Estradiol / Q000097:blood*; D015914:Estrogen Replacement Therapy; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D017698:Postmenopause / Q000502:physiology*; D011498:Protein Precursors / Q000097:blood / Q000652:urine; D012044:Regression Analysis
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D011498:Protein Precursors; D015675:Osteocalcin; D004958:Estradiol; C015484:pyridinoline; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C036020:deoxypyridinoline; D003094:Collagen