Ion-pair formation of Bi(III)-iodide with some nitrogenous drugs and its application to pharmaceutical preparations.
A systematic spectrophotometric study on the ion-pair formation of Bi(III)-iodide with amineptine hydrochloride, piribedil and trimebutine maleate is carried out. The optimal experimental conditions pH, concentration of Bi(III) nitrate, potassium iodide; and the nature and amount of organic solvent have been studied. The ion pairs are soluble in 1,2-dichloroethane and the optimum pH range is 2.0-2.8. By application of the methods of Sommer and Job involving non-equimolar solutions, the conditional stability constant (log K') of the Bi(III) piridedil ion pair (1:1) at the optimum pH of 2.4 and an ionic strength (mu) 0.1 M, was found to be 5.436. The validity of Beer's law has been tested in the concentration range 5-50 microg ml(-1) in the organic layer, the relative standard deviation is less than 1%. The method is applied to the determination of these drugs in tablets without interference.
Abdel-Gawad
F M
FM
National Organization for Drug Control and Research, Cairo, Egypt.
D016477:Artifacts; D001729:Bismuth / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007454:Iodides / Q000737:chemistry*; D007477:Ions; D009584:Nitrogen / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010891:Piribedil / Q000737:chemistry*; D014287:Trimebutine / Q000737:chemistry*
D007454:Iodides; D007477:Ions; D004364:Pharmaceutical Preparations; C048121:bismuth iodide; D010891:Piribedil; D009584:Nitrogen; D014287:Trimebutine; D001729:Bismuth