HIV infection and SLE: their pathogenic relationship.
Retroviruses have repeatedly been suggested as a possible trigger mechanism for systemic lupus erythematosus (SLE). We review the role of human immunodeficiency virus (HIV)-1 envelope glycoprotein (gp120) in the induction of immune dysregulation including autoimmunity in HIV-1 infection, and discuss the possible relationship between HIV and SLE in the retroviral etiology.
Sekigawa
I
I
Department of Medicine, Juntendo University, Izu-Nagaoka Hospital, Shizuoka, Japan.
Kaneko
H
H
Hishikawa
T
T
Hashimoto
H
H
Hirose
S
S
Kaneko
Y
Y
Maruyama
N
N
D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology / Q000821:virology*; D015699:HIV Envelope Protein gp120 / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology / Q000821:virology*; D012192:Retroviridae Infections / Q000150:complications*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D015699:HIV Envelope Protein gp120; D014409:Tumor Necrosis Factor-alpha