title: Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders.
abstract: To clarify the different roles of free radical scavenging systems in various thyroid disorders, we measured the levels of alpha-, beta-, and gamma-tocopherols and coenzyme Q in the thyroid tissues of patients with thyroid tumors and Graves' disease using high-performance liquid chromatography. The levels of alpha-tocopherols and gamma-tocopherols in the thyroid tissue of patients with papillary carcinoma and the level of gamma-tocopherol in the thyroid tissue of patients with malignant lymphoma were elevated compared with those in normal thyroid tissues. The level of coenzyme Q was reduced in the thyroid tissue of patients with Graves' disease and follicular and papillary thyroid carcinomas. These findings imply that vitamin E and coenzyme Q as scavengers play some role in thyroid follicular cell hyperfunction or dysfunction.
authors.affiliation: Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mano
authors.forename: K
authors.initials: K
authors.lastname: Iwase
authors.forename: R
authors.initials: R
authors.lastname: Hayashi
authors.forename: N
authors.initials: N
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Uchimura
authors.forename: M
authors.initials: M
authors.lastname: Makino
authors.forename: M
authors.initials: M
authors.lastname: Nagata
authors.forename: Y
authors.initials: Y
authors.lastname: Sawai
authors.forename: N
authors.initials: N
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Aono
authors.forename: A
authors.initials: A
authors.lastname: Nakai
authors.forename: A
authors.initials: A
authors.lastname: Nagasaka
authors.forename: M
authors.initials: M
authors.lastname: Itoh
mesh_terms: D006111:Graves Disease / Q000378:metabolism*; D006801:Humans; D013961:Thyroid Gland / Q000737:chemistry*; D013964:Thyroid Neoplasms / Q000737:chemistry*; D014451:Ubiquinone / Q000032:analysis*; D014810:Vitamin E / Q000032:analysis*
chemical_list: D014451:Ubiquinone; D014810:Vitamin E