Natural history of Epstein-Barr virus infection in a prospective pediatric cohort born to human immunodeficiency virus-infected mothers.
To determine whether Epstein-Barr virus (EBV) constitutes a contributing factor in AIDS and, conversely, whether the human immunodeficiency virus (HIV) alters the course of primary EBV infection in a pediatric population, 62 children born to HIV-infected mothers and prospectively followed were evaluated. EBV infection was documented by EBV-specific serology and polymerase chain reaction and by clinical history. HIV infection status was determined according to the Centers for Disease Control and Prevention pediatric classification system. Demographics from HIV-infected and HIV-uninfected children were comparable. The data suggest that HIV-infected children may acquire primary EBV infection earlier in life. The incidence of accompanying splenomegaly or hepatomegaly (or both) around the time of EBV seroconversion was higher among HIV-infected children than among HIV-uninfected children. In contrast, HIV disease progression and HIV-1 RNA load did not seem to be influenced by primary EBV infection.
Pedneault
L
L
Department of Microbiology and Infectious Diseases, Research Center, and Centre Maternel et Infantile sur le SIDA, Hôpital Sainte-Justine, Montréal, Canada. LP88709@glaxowellcome.com
Lapointe
N
N
Alfieri
C
C
Ghadirian
P
P
Carpentier
L
L
Samson
J
J
Joncas
J
J
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000821:virology; D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D002213:Capsid / Q000276:immunology; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006529:Hepatomegaly / Q000175:diagnosis / Q000453:epidemiology; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000453:epidemiology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D011446:Prospective Studies; D012367:RNA, Viral / Q000302:isolation & purification; D013163:Splenomegaly / Q000175:diagnosis / Q000453:epidemiology; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000453:epidemiology*; D019562:Viral Load
D000914:Antibodies, Viral; D004279:DNA, Viral; D012367:RNA, Viral