Two new cytotoxic compounds from Tapirira guianensis.
Two new cytotoxic compounds, 2-[10(Z)-heptadecenyl]-1,4-hydroquinone (1) and (4R,6R)-dihydroxy-4-[10(Z)-heptadecenyl]-2-cyclohexenone (2) have been isolated from a MeOH extract of seeds of Tapirira guianensis. The structures were established through spectral analysis of the isolates and their derivatives.
David
J M
JM
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.
Chávez
J P
JP
Chai
H B
HB
Pezzuto
J M
JM
Cordell
G A
GA
D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D003512:Cyclohexanones / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006873:Hydroquinones / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
C111690:2-(10-heptadecenyl)-1,4-hydroquinone; D000972:Antineoplastic Agents, Phytogenic; D003512:Cyclohexanones; D006873:Hydroquinones; C111691:dihydroxy-4-(10-heptadecenyl)-2-cyclohexenone