Neurological manifestations of chronic myelogenous leukaemia.
Neurological manifestations occur in about one-quarter of patients with chronic myelogenous leukaemia (CML), usually as a result of hyperleukocytosis, predisposing to intravascular thrombus formation. We report the clinical and pathological findings in a 16-year-old female with CML who presented with deafness, blindness and paraplegia, and discuss possible aetiopathogenetic mechanism.
Aken'Ova
Y A
YA
Department of Haematology, University College Hospital, Ibadan, Nigeria.
Okunade
M A
MA
Akang
E E
EE
D000293:Adolescent; D001766:Blindness / Q000209:etiology*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000556:secondary; D003638:Deafness / Q000209:etiology*; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D010264:Paraplegia / Q000209:etiology*