title: An atlas of serpin conformations.
abstract: The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed-->relaxed (S-->R) transition. This article is a guide to the known serpin conformations and their biological significance.
authors.affiliation: Department of Haematology, University of Cambridge, MRC Centre, UK.
authors.forename: J
authors.initials: J
authors.lastname: Whisstock
authors.forename: R
authors.initials: R
authors.lastname: Skinner
authors.forename: A M
authors.initials: AM
authors.lastname: Lesk
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015843:Serpins / Q000737:chemistry* / Q000235:genetics
chemical_list: D015843:Serpins