title: Duodenal perforation in a cheetah (Acinonyx jubilatus).
abstract: An 11-yr-old female cheetah (Acinonyx jubilatus) from a privately owned breeding center for endangered species was referred for evaluation with a history of vomiting and depression of 10 days' duration. After anesthetic induction with tiletamine and zolazepam and anesthetic maintenance with isoflurane, a complete diagnostic workup was performed, including hematology, serum chemistry, and radiography. The clinical diagnosis was septic suppurative inflammation and hemorrhage in the abdomen, consistent with perforation or rupture of the gastrointestinal tract. An exploratory laparotomy showed a perforated duodenal ulcer, which was resected. Subsequent endoscopy revealed no further evidence of ulceration in the upper gastrointestinal tract. Biopsy of the ulcerated tissue collected from the duodenum revealed Gastrospirillum-like organisms. Histologic examination revealed widespread infiltration of lymphocytes and plasma cells into the lamina propria and submucosa. Intraepithelial leukocytes were present along with attenuation, erosion, and ulceration of the superficial epithelium. Fourteen days after surgery, this cheetah was returned to its breeding compound, and no subsequent vomiting has been observed for 4 yr.
authors.affiliation: Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Veterinary Teaching Hospital, Texas A&M University, College Station 77843-4475, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Johnson
authors.forename: A M
authors.initials: AM
authors.lastname: Wolf
authors.forename: J M
authors.initials: JM
authors.lastname: Jensen
authors.forename: T
authors.initials: T
authors.lastname: Fossum
authors.forename: D
authors.initials: D
authors.lastname: Rohn
authors.forename: R W
authors.initials: RW
authors.lastname: Green
authors.forename: M
authors.initials: M
authors.lastname: Willard
mesh_terms: D002612:Acinonyx; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001707:Biopsy, Needle / Q000662:veterinary; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D004384:Duodenoscopy / Q000662:veterinary; D004386:Duodenum / Q000382:microbiology; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones; D005773:Gastroscopy / Q000662:veterinary; D016998:Helicobacter / Q000302:isolation & purification; D010439:Peptic Ulcer Perforation / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D011182:Postoperative Care / Q000662:veterinary; D015363:Quinolones / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use; D013392:Sucralfate / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000897:Anti-Ulcer Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin; D013392:Sucralfate; D011899:Ranitidine