Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs.
The MHC fold, with its well-characterized peptide-binding groove, can perform other functions in addition to presentation of antigenic peptides to T cells. Homologs of MHC molecules have diverse roles that include presentation of lipid antigens (by CD1), transport of immunoglobulins (by the neonatal Fc receptor), regulation of iron metabolism (by the hemochromatosis gene product, HFE), and deception of the host immune system (by viral homologs). Recent crystal structures of two of these non-standard MHC-like molecules have allowed comparison of the recognition properties of classical. MHC molecules with those of their unusual homologs.
Wilson
I A
IA
Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA. wilson@scripps.edu
Bjorkman
P J
PJ
D000818:Animals; D018949:Antigens, CD1 / Q000737:chemistry* / Q000276:immunology; D000956:Antigens, Viral / Q000737:chemistry* / Q000276:immunology; D006680:HLA Antigens / Q000737:chemistry* / Q000276:immunology; D006432:Hemochromatosis; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology; D008565:Membrane Proteins; D011961:Receptors, Fc / Q000737:chemistry* / Q000276:immunology
D018949:Antigens, CD1; D000956:Antigens, Viral; C103673:HFE protein, human; D006680:HLA Antigens; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D011961:Receptors, Fc