title: Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: first clinical and histopathological results.
abstract: In a first clinical trial with the apoptosis-inducing human antibody SC-1 eight patients with poorly differentiated stomach adenocarcinoma of diffuse-type received 20 or 30 mg of purified SC-1 antibody intravenously, followed 24 or 48 h later by gastrectomy and lymphadenectomy. In seven cases a significant induction of apoptotic activity was measured in primary tumors as compared with earlier biopsy material and in five patients a significant regression of tumor mass could be determined histopathologically. No toxic crossreactivity was observed with normal tissue or organs of patients.
authors.affiliation: Institut für Pathologie, Josef-Schneider-Str. 2, Würzburg, 97080, Germany.
authors.forename: H P
authors.initials: HP
authors.lastname: Vollmers
authors.forename: U
authors.initials: U
authors.lastname: Zimmermann
authors.forename: V
authors.initials: V
authors.lastname: Krenn
authors.forename: W
authors.initials: W
authors.lastname: Timmermann
authors.forename: B
authors.initials: B
authors.lastname: Illert
authors.forename: F
authors.initials: F
authors.lastname: Hensel
authors.forename: R
authors.initials: R
authors.lastname: Hermann
authors.forename: A
authors.initials: A
authors.lastname: Thiede
authors.forename: M
authors.initials: M
authors.lastname: Wilhelm
authors.forename: H
authors.initials: H
authors.lastname: Rückle-Lanz
authors.forename: L
authors.initials: L
authors.lastname: Reindl
authors.forename: H K
authors.initials: HK
authors.lastname: Müller-Hermelink
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000302:isolation & purification / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D003131:Combined Modality Therapy; D053938:DNA Fragmentation; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007167:Immunotherapy; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; C111124:SC-1 monoclonal antibody