The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions.
The role of platelet-activating factor (PAF, a phospholipid compound) in regulation of cell functions and cell-cell interactions is reviewed. The biological effects of PAF on platelets, neutrophils, basophils, eosinophiles, lymphocytes, and endothelial cells are described. Mechanisms of cell activation by PAF are discussed. Interactions of PAF with other biological regulators (prostaglandins, leukotrienes, NO, tumor necrosis factor, and interleukins) are considered.
Kulikov
V I
VI
Research and Development Center for Medical Biotechnology, Ministry of Health of the Russian Federation, Moscow, Russia.
Muzya
G I
GI
D000818:Animals; D002450:Cell Communication / Q000502:physiology; D004347:Drug Interactions; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D010972:Platelet Activating Factor / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology; D010980:Platelet Membrane Glycoproteins / Q000502:physiology; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled
D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor