Is the risk of urinary tract tumorigenesis enhanced by a marginal chronic essential fatty acid deficiency (EFAD)?
A considerable amount of experimental, clinical and epidemiological data indicate that dietary fats play a role in urinary tract tumorigenesis. In rodents, chronic essential fatty acid (EFA) deficiency seems to induce both urolithiasis and transitional hyperplasias, followed by a tendency for tumorigenesis of the urinary passages. High intake of saturated fats or non-EFAs, conditions that may induce EFA deficiency (EFAD) increase the risk of bladder cancer in case-control studies. In other cell populations, EFAs are beneficial as preventive and therapeutic nutrients for the treatment of cancer. Thus, it is reasonable to assume that abnormal metabolism and/or nutritional deprivation of EFA, by inducing a chronic or a subclinical EFA deficiency, may enhance the risk of urothelial tumorigenesis.
Eynard
A R
AR
Instituto de Biología Celular, Facultad de Ciencias Médicas, Córdoba, Argentina.
D004848:Epithelium / Q000473:pathology; D005228:Fatty Acids, Essential / Q000172:deficiency*; D006801:Humans; D009747:Nutritional Physiological Phenomena; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D014571:Urologic Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology
D005228:Fatty Acids, Essential