title: Transforming growth factor-beta gene expression in avian Low Score Normal pectoral muscle.
abstract: The avian Low Score Normal (LSN) genetic muscle weakness is phenotypically characterized by a reduction in the ability of birds to right themselves from a supine position. In previous studies, LSN birds exhibited elevated levels of decorin transcript and protein at embryonic Day 20 and a large increase in collagen crosslinking at 6 wk posthatch. Transforming growth factor-beta (TGF-beta) expression has been reported to control decorin expression. Steady state levels of TGF-beta1 and TGF-beta2 transcripts were determined in ovo and posthatch in order to initiate an investigation of the mechanism underlying decorin expression. On embryonic Day 20 through 1 wk posthatch, TGF-beta2 transcript levels were elevated, whereas an increase in TGF-beta1 was only noted at 1 d posthatch. These data suggest that the increase in decorin expression may be associated with a modification in a TGF-beta signal transduction pathway.
authors.affiliation: Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA. velleman.1@osu.edu
authors.forename: S G
authors.initials: SG
authors.lastname: Velleman
authors.forename: C S
authors.initials: CS
authors.lastname: Coy
mesh_terms: D000375:Aging; D000818:Animals; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics*; D058575:Decorin; D016326:Extracellular Matrix Proteins; D018507:Gene Expression Regulation, Developmental; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D009137:Muscular Dystrophy, Animal / Q000235:genetics*; D011201:Poultry Diseases; D011509:Proteoglycans / Q000096:biosynthesis; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D058575:Decorin; D016326:Extracellular Matrix Proteins; D011509:Proteoglycans; D016212:Transforming Growth Factor beta