title: Eukaryotic transcription factors.
abstract: The structural characterization of eukaryotic transcription factors that interact with DNA has advanced on two fronts in the past two years. New complexes of transcription factors bound to TATA-box DNA include the TFIIA-TBP-DNA complex as well as human and archaeal TBP-DNA and TFIIB-TBP-DNA complexes, respectively. In addition, recent studies of proximal/distal promoter complexes demonstrate that DNA-binding motifs may be modified in nature by adding secondary structure elements to diversify DNA-binding specificities and affinities.
authors.affiliation: ETH-Zürich, Institut für Molekularbiologie und Biophysik, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Tan
authors.forename: T J
authors.initials: TJ
authors.lastname: Richmond
mesh_terms: D000818:Animals; D001105:Archaea / Q000737:chemistry; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D019281:Dimerization; D018257:Helix-Loop-Helix Motifs; D019077:Helix-Turn-Helix Motifs; D006801:Humans; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D016385:TATA Box; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D016335:Zinc Fingers
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors