Platelet aggregation and lipoprotein levels in a patient with familial hypercholesterolemia after selective LDL-apheresis.
Platelet aggregation was studied in a patient with familial hypercholesterolemia immediately after apheresis selective for low-density lipoprotein (LDL), a lipid-lowering procedure. This treatment reduced plasmatic levels of total and LDL-cholesterol, apo B, and triglyceride. Increased platelet aggregation was reduced immediately after the apheresis in whole blood as well as in platelet-rich plasma. However, aggregation in washed platelets remained unchanged after LDL-apheresis. In conclusion, in this patient reduction of LDL-cholesterol improved platelet function in the very short term.
Pares
M N
MN
Research and Molecular Biology Division, Fundação Pró-Sangue Hemocentro de São Paulo, Brazil.
D'Amico
E A
EA
Kutner
J M
JM
Chamone
D de A
Dde A
Bydlowski
S P
SP
D000328:Adult; D001781:Blood Component Removal; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood; D010974:Platelet Aggregation; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D014280:Triglycerides