Origin DNA-binding proteins.
The first step in DNA replication involves the recognition of origin DNA sequences by origin-binding proteins. The three-dimensional structures of three different origin DNA-binding proteins have recently been solved. These proteins form a structural class distinct from other DNA-binding proteins. One of the origin-binding proteins, Epstein-Barr virus nuclear antigen 1, most likely has two modes of DNA binding; the sequential use of these modes may be important for the initiation of DNA replication.
Edwards
A M
AM
Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada. aled.edwards@utoronto.ca
Bochkarev
A
A
Frappier
L
L
D000952:Antigens, Polyomavirus Transforming / Q000737:chemistry; D004261:DNA Replication; D004279:DNA, Viral / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D019281:Dimerization; D019309:Epstein-Barr Virus Nuclear Antigens / Q000737:chemistry* / Q000378:metabolism; D004854:Herpesvirus 4, Human; D008958:Models, Molecular; D011487:Protein Conformation; D018741:Replication Origin; D017385:Sequence Homology; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism
D000952:Antigens, Polyomavirus Transforming; D004279:DNA, Viral; D004268:DNA-Binding Proteins; C051550:E2 protein, Bovine papillomavirus; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins