title: Antiperoxide effect of garlic protein in alcohol fed rats.
abstract: Rats fed ethanol (3.76g/Kg body wt/day) for about 45 days exhibited high levels of tissue malondialdehyde, hydroperoxide and diene conjugates. Activity of tissue superoxide dismutase, catalase, and glutathione content decreased. Administration of water soluble proteins of garlic (500 mg/kg body wt/day) to alcohol fed rats showed significant increase in antiperoxide activity and decrease in the activity of glutathione peroxidase and glutathione s transferase as compared to a standard drug gugulipid (50 mg/kg body wt/day).
authors.affiliation: Department of Biochemistry, University of Kerala, Thiruvananthapuram, India.
authors.forename: C R
authors.initials: CR
authors.lastname: Rajasree
authors.forename: T
authors.initials: T
authors.lastname: Rajamohan
authors.forename: K T
authors.initials: KT
authors.lastname: Augusti
mesh_terms: D000437:Alcoholism / Q000178:diet therapy* / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005737:Garlic / Q000737:chemistry*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010545:Peroxides / Q000037:antagonists & inhibitors*; D014674:Plant Proteins, Dietary / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D010545:Peroxides; D014674:Plant Proteins, Dietary; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione