Autoimmune thyroid disease and insulin-dependent diabetes mellitus during pregnancy and post partum.
The aim of this study was to assess thyroid dysfunction and autoimmunity in pregnant insulin-dependent diabetes mellitus (IDDM) women during pregnancy and early post partum. Fifteen pregnant IDDM women and 77 healthy pregnant women were studied. Free T4, TSH, TPO-Ab and Tg-Ab were assayed during the first and third trimester of pregnancy and 3 months post partum. In IDDM women FT4 levels significantly decreased (p < 0.05) during third trimester and 3 months post partum and also TPO-Ab during third trimester (p < .01). 26% of IDDM and 4% of the controls presented post partum thyroid dysfunction. We recommend that prepregnant IDDM be screened for TPO-Ab. Those with a positive result would be followed with serial monitoring of free T4 and TSH levels during each trimester as well as during the post partum period.
González-Jiménez
A
A
Endocrinology and Nutrition Service, University of Granada Hospital, Spain.
Fernández-Soto
M L
ML
Lobón-Hernández
J A
JA
López-Medina
J A
JA
Navarrete
L
L
Escobar-Jiménez
F
F
D000293:Adolescent; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications*; D011446:Prospective Studies; D013960:Thyroid Function Tests; D013967:Thyroiditis, Autoimmune / Q000150:complications*