Fournier's gangrene during induction treatment of acute promyelocytic leukemia, a case report.
Fournier's gangrene is described as a fulminant necrotizing fasciitis of the scrotum and penis. Few cases have been reported in the context of acute leukemia. We describe a case, complicating the induction treatment of an acute promyelocytic leukemia with all-trans-retinoic acid and chemotherapy. The evolution was favorable, following surgical excision and broad-spectrum antibiotic therapy. The respective roles of all-trans-retinoic acid and granulocytopenia are discussed. This devastating and life-threatening infection must be kept in mind for early clinical, bacteriological, and radiological diagnosis and surgical management.
Lévy
V
V
Service d'Hematologie, Hôtel-Dieu de Paris, France.
Jaffarbey
J
J
Aouad
K
K
Zittoun
R
R
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018934:Fournier Gangrene / Q000139:chemically induced* / Q000188:drug therapy / Q000601:surgery; D005832:Genital Diseases, Male / Q000139:chemically induced; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D012611:Scrotum; D014212:Tretinoin / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D014212:Tretinoin