Postirradiation sarcomas in Sprague-Dawley rats.
A series of radiation-induced neoplasms occurred in Sprague-Dawley rats 4-8 months after irradiation of a single hind leg with 60Co gamma rays. The rats were exposed to fractionated cumulative doses that ranged from 0 to 106 Gy. Osteosarcomas, malignant fibrous histiocytomas and fibrosarcomas developed in the radiation fields of a number of the rats in the higher-dose groups. Tumors did not develop throughout an 8-month observation period in rats that received doses of only 0 or 46 Gy. The most common postirradiation sarcomas in humans are osteosarcoma, malignant fibrous histiocytoma and fibrosarcoma. The Sprague-Dawley rat may serve as a good animal model in studying the development of sarcoma in humans after regional radiotherapy.
Tinkey
P T
PT
Department of Veterinary Medicine and Surgery, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Lembo
T M
TM
Evans
G R
GR
Cundiff
J H
JH
Gray
K N
KN
Price
R E
RE
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005354:Fibrosarcoma / Q000209:etiology; D005720:Gamma Rays; D018219:Histiocytoma, Benign Fibrous / Q000209:etiology; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D012516:Osteosarcoma / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012513:Sarcoma, Experimental / Q000209:etiology* / Q000473:pathology