title: Myelodysplasia during the course of myeloma. Restriction of 17p deletion and p53 overexpression to myeloid cells.
abstract: We report a case of myelodysplastic syndrome (MDS) occurring during the course of multiple myeloma (MM) treated by alkylating agents. Karyotype showed unbalanced t(5;17), resulting in 17p deletion. Dysgranulopoïesis typical of the '17p-syndrome' and p53 mutation and overexpression were present. A combination of FISH and immunophenotype analysis (FICTION, analysis) showed that 17p deletion was restricted to myeloid cells, and that p53 overexpression was also restricted to myeloid cells. These findings strongly argue against a common clonal origin of MM and MDS, and support the hypothesis that MM and MDS were clonally unrelated, and that MDS was indeed secondary to treatment with alkylating agents.
authors.affiliation: Laboratoire d'Hématologie, CHU Lille, France.
authors.forename: V
authors.initials: V
authors.lastname: Soenen
authors.forename: C
authors.initials: C
authors.lastname: Preudhomme
authors.forename: C
authors.initials: C
authors.lastname: Roumier
authors.forename: J L
authors.initials: JL
authors.lastname: Laï
authors.forename: P
authors.initials: P
authors.lastname: Lepelley
authors.forename: T
authors.initials: T
authors.lastname: Facon
authors.forename: D
authors.initials: D
authors.lastname: Pagniez
authors.forename: P
authors.initials: P
authors.lastname: Fenaux
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5; D016158:Genes, p53; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000235:genetics* / Q000378:metabolism; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics* / Q000378:metabolism; D018807:Polymorphism, Single-Stranded Conformational; D014178:Translocation, Genetic; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D016159:Tumor Suppressor Protein p53