Ceramic drug-delivery devices.
A variety of ceramics and delivery systems have been used to deliver chemicals, biologicals, and drugs at various rates for desired periods of time from different sites of implantation. In vitro and in vivo studies have shown that ceramics can successfully be used as drug-delivery devices. Matrices, inserts, reservoirs, cements, and particles have been used to deliver a large variety of therapeutic agents such as antibiotics, anticancer drugs, anticoagulants, analgesics, growth factors, hormones, steroids, and vaccines. In this article, the advantages and disadvantages of conventional drug-delivery systems and the different approaches used to deliver chemical and biological agents by means of ceramic systems will be reviewed.
Lasserre
A
A
Department of Biology, University of Dayton, OH 45469, USA.
Bajpai
P K
PK
D000700:Analgesics / Q000008:administration & dosage; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019380:Anti-HIV Agents / Q000008:administration & dosage; D000925:Anticoagulants / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002516:Ceramics; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004343:Drug Implants; D006133:Growth Substances / Q000008:administration & dosage; D006728:Hormones / Q000008:administration & dosage; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013256:Steroids / Q000008:administration & dosage; D014612:Vaccines / Q000008:administration & dosage
D000700:Analgesics; D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000925:Anticoagulants; D000970:Antineoplastic Agents; D004343:Drug Implants; D006133:Growth Substances; D006728:Hormones; D004364:Pharmaceutical Preparations; D013256:Steroids; D014612:Vaccines