title: Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha.
abstract: Plasma leptin and ob gene mRNA levels were increased in mice following bacterial peritonitis, and blocking an endogenous tumor necrosis factor alpha (TNF-alpha) response blunted the increase. However, plasma leptin concentrations did not correlate with the associated anorexia. We conclude that leptin expression is under partial regulatory control of TNF-alpha in peritonitis, but the anorexia is not dependent on increased leptin production.
authors.affiliation: Department of Surgery, University of Florida College of Medicine, Gainesville 32610, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Moshyedi
authors.forename: M D
authors.initials: MD
authors.lastname: Josephs
authors.forename: E K
authors.initials: EK
authors.lastname: Abdalla
authors.forename: S L
authors.initials: SL
authors.lastname: Mackay
authors.forename: C K
authors.initials: CK
authors.lastname: Edwards
authors.forename: E M
authors.initials: EM
authors.lastname: Copeland
authors.forename: L L
authors.initials: LL
authors.lastname: Moldawer
mesh_terms: D000818:Animals; D000855:Anorexia / Q000209:etiology*; D001424:Bacterial Infections / Q000378:metabolism*; D005260:Female; D020738:Leptin; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000235:genetics; D010538:Peritonitis / Q000378:metabolism*; D014176:Protein Biosynthesis; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
chemical_list: D020738:Leptin; D014409:Tumor Necrosis Factor-alpha