Early stages in male germ cell differentiation in the mouse. Review article.
Primordial germ cells arise during gastrulation and migrate from the hindgut into the gonad primordium during early organogenesis. In this article, we discuss factors that control migration, proliferation and targeting of the PGCs. In particular we discuss how changes in adhesiveness control germ cell positioning in the gonad, and the molecules involved.
Anderson
R
R
Department of Cell Biology and Neuroanatomy, University of Minnesota School of Medicine, Minneapolis 55455, USA.
Garcia-Castro
M
M
Heasman
J
J
Wylie
C
C
D000818:Animals; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005854:Germ Cells / Q000166:cytology* / Q000502:physiology; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D013737:Testis / Q000166:cytology* / Q000196:embryology / Q000502:physiology
D002241:Carbohydrates