title: Adherence of two film-forming medications to the oral mucosa.
abstract: This study provides a comparison among 10 patients of old and new formulas of Zilactin (Zila Pharmaceuticals, Phoenix). The original formula contained tannic acid; the new formula replaced tannic acid with benzyl alcohol as the active ingredient. The U.S Food and Drug Administration's (FDA) ruling that tannic acid must be eliminated as the active ingredient from the Zilactin formula was the reason for the change. In the study, no side effects were reported for either formula, except for a minor burning sensation at the time of application. Moreover, the new Zilactin formula, on average, provided a statistically significant rate of adherence of 21 percent to the oral mucosa.
authors.affiliation: University of the Pacific School of Dentistry, San Francisco, CA 94115, USA.
authors.forename: W
authors.initials: W
authors.lastname: Carpenter
authors.forename: T
authors.initials: T
authors.lastname: Schiff
authors.forename: D
authors.initials: D
authors.lastname: Fat
mesh_terms: D000268:Adhesiveness; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D019226:Oral Ulcer / Q000188:drug therapy*
chemical_list: D002482:Cellulose; C008079:hydroxypropylcellulose