Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells.
The pleiotropic biological activities of interleukin-18 (IL-18) are mediated by IL-18 receptor (IL-18R). When the ligand binds to the IL-18R, IL-18R initiates a signaling cascade that results in the activation of nuclear factor kappa B (NF-kappa B). When mouse EL-4 cells were exposed to IL-18, IL-1 receptor-associated kinase (IRAK) was recruited to IL-18R and was phosphorylated. In addition, tumor necrosis factor receptor-associated factor-6 (TRAF6) was associated with IRAK. Therefore, we concluded that IL-18/IL-18R-mediated signaling may share the IRAK/TRAF6 pathway through NF-kappa B activation with the IL-1/IL-1 receptor system.
Kojima
H
H
Fujisaki Institute, Hayashibara Biochemical Labs., Inc., Okayama, Japan.
Takeuchi
M
M
Ohta
T
T
Nishida
Y
Y
Arai
N
N
Ikeda
M
M
Ikegami
H
H
Kurimoto
M
M
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology*; D004789:Enzyme Activation; D053592:Interleukin-1 Receptor-Associated Kinases; D020382:Interleukin-18; D007378:Interleukins / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism* / Q000502:physiology; D011506:Proteins; D017472:Receptors, Interleukin-1 / Q000378:metabolism* / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013601:T-Lymphocytes / Q000201:enzymology / Q000378:metabolism; D048029:TNF Receptor-Associated Factor 6; D013945:Thymoma; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D016207:Cytokines; D020382:Interleukin-18; D007378:Interleukins; D016328:NF-kappa B; D011506:Proteins; D017472:Receptors, Interleukin-1; D018124:Receptors, Tumor Necrosis Factor; D048029:TNF Receptor-Associated Factor 6; D011494:Protein Kinases; D053592:Interleukin-1 Receptor-Associated Kinases