No effect of chloroquine on theophylline pharmacokinetics in the rat.
The immediate and delayed effects of chloroquine on theophylline kinetics were investigated in rats pretreated with chloroquine diphosphate (45 mg kg-1) or saline intraperitoneally. One hour or 4 days after chloroquine, theophylline (10 mg kg-1) was administered intravenously. Compared with the control animals pretreated with saline, the disposition parameters of theophylline was not altered after pretreatment with chloroquine. Chloroquine did not affect the in vivo metabolism of theophylline in the laboratory rat. A possible decrease in theophylline's volume of distribution at 4 days, but not immediately, after administration of chloroquine was suggested, although this just failed to achieve statistical significance (p = 0.055). Being marginal, it is unlikely to be of clinical concern. It is concluded that, judged from these animal data, there is no evidence of a drug-drug pharmacokinetic interaction for the combination of chloroquine and theophylline.
Motti
B A
BA
Department of Biopharmaceutics and Pharmacokinetics, Uppsala University, Sweden.
Ashton
M
M
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D003627:Data Interpretation, Statistical; D004347:Drug Interactions; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D013997:Time Factors; D014665:Vasodilator Agents / Q000493:pharmacokinetics*
D000962:Antimalarials; D014665:Vasodilator Agents; D002738:Chloroquine; D013806:Theophylline