title: Oral mucosal lesions in patients with acute leukemias and related disorders due to cytotoxic therapy.
abstract: Forty-seven children afflicted with acute leukemia were studied at the Tata Memorial Hospital Bombay to record the occurrence of oral manifestations prior to and during chemotherapy. Lymphadenopathy was the most frequent single finding suggestive of leukemia during head and neck examination. Gingival abnormalities, bleeding gums and oral mucosal pallor were the other findings on initial oral examination. Due to immunosuppression caused by the chemotherapy drugs oral mucosal ulcerations, uncontrolled herpes, candidiasis and pseudomoniasis were observed.
authors.affiliation: Nair Hospital Dental College, Bombay.
authors.forename: A M
authors.initials: AM
authors.lastname: Baliga
authors.forename: V R
authors.initials: VR
authors.lastname: Brave
authors.forename: H A
authors.initials: HA
authors.lastname: Vyas
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008207:Lymphatic Metastasis; D008297:Male; D009059:Mouth Diseases / Q000139:chemically induced* / Q000473:pathology; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents