Assignment of three Chinese xeroderma pigmentosum patients to complementation group C and one to group E.
Four Chinese patients with xeroderma pigmentosum (XP), who had different degrees of skin symptoms, were tested for their genetic complementation groups. Skin fibroblasts obtained from the patients were used for complementation analysis done by a cell-fusion technique. Three of the patients belonged to group C and one, who had the mildest cutaneous manifestations, to group E. This is the first report of a group E XP patient in China. Our present findings together with previous reports suggest that group C XP is more common in China, similar to the distribution among Caucasian XP patients but markedly different from the Japanese distribution.
Han
Z B
ZB
Radiation Biology Center, Kyoto University, Japan.
Hara
R
R
Ayaki
H
H
Wang
J H
JH
Sun
L Y
LY
You
Y
Y
Zhang
Y P
YP
Qiang
K X
KX
Ikenaga
M
M
D000293:Adolescent; D000328:Adult; D002110:Caffeine / Q000494:pharmacology; D018929:Cell Culture Techniques; D002459:Cell Fusion; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002681:China; D004260:DNA Repair; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D005816:Genetic Complementation Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000208:ethnology / Q000235:genetics*
D002110:Caffeine