title: [Retrospective study of drug-induced agranulocytosis in hospitalized patients in Geneva and comparison with cases reported to IOCM].
abstract: In a retrospective study, 19 cases classified as idiosyncratic drug-induced agranulocytosis were found among 162 files of patients hospitalized in internal medicine clinics of the university hospital where this diagnosis had been coded. This would give an estimated incidence of 2.6 cases per million inhabitants per year for the Geneva area. In most cases several drugs were implicated in causation of the episodes. Suspected drugs were those commonly reported in the literature, but also some drugs which might already have been taken to treat infectious complications of agranulocytosis. A comparison of the Geneva cases with those notified to the Swiss Intercantonal Office for the Control of Medicines reveals a similar profile of involved drugs.
authors.affiliation: Division de pharmacologie clinique, Hôpital Cantonal Universitaire, Genève.
authors.forename: J C
authors.initials: JC
authors.lastname: Krayenbühl
authors.forename: M K
authors.initials: MK
authors.lastname: Oestreicher
authors.forename: J
authors.initials: J
authors.lastname: Sievering
authors.forename: R
authors.initials: R
authors.lastname: Stoller
authors.forename: P
authors.initials: P
authors.lastname: Dayer
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D000380:Agranulocytosis / Q000139:chemically induced* / Q000453:epidemiology; D015984:Causality; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010343:Patient Admission / Q000706:statistics & numerical data*; D013557:Switzerland; D014505:Urban Population / Q000706:statistics & numerical data*
vernacular_title: Etude rétrospective des cas d'agranulocytose médicamenteuse hospitalisés à Genève et comparaison avec les cas notifiés à l'OICM.