title: CT scan texture analysis of the distal radius: influence of age and menopausal status.
abstract: OBJECTIVE
  To gain information on bone architecture by performing bone texture analysis in a sample of women covering a broad age range.
  
  
  METHODS
  We studied 29 healthy women aged 23 to 80 years (55 +/- 18 years), 19 of whom were postmenopausal. None was taking drugs known to influence bone mass or bone metabolism. Computed tomography of the nondominant distal radius was performed with 1 mm slice thickness and 1 mm gap. Four consecutive coronal and four consecutive axial sections were selected for each patient and entered into a PC-type computer. Bone texture was evaluated using grey level run length analysis (five parameters), differential local variation analysis (four parameters), fractal analysis (two parameters), trabecular network extraction and three-dimensional relief characterization. The mean of each study parameter for the four coronal sections and for the four axial sections was calculated. Absorptiometry was done in 16 patients.
  
  
  RESULTS
  Linear correlations with age were strongest (P < 0.001) for parameters measured on coronal sections by trabecular network extraction, i.e., trabecular bone volume (r = -0.68), trabecular plate separation (r = -0.65), total skeletal length (r = -0.71), number of nodes (r = 0.73), number of node-node segments (r = -0.74) and trabecular bone pattern factor (r = 0.71). Also, these parameters were significantly different between premenopausal women (33 +/- 9 years) and postmenopausal women (67.3 +/- 9 years). Correlations between bone mineral density and texture parameters were few in number and modest in strength, suggesting that the parameters measured may reflect bone structure rather than bone mass.
  
  
  CONCLUSIONS
  Bone texture in women undergoes changes with advancing age that may reflect alterations in bone microarchitecture.
authors.affiliation: Rheumatology Department, Lille Teaching Hospital, France.
authors.forename: B
authors.initials: B
authors.lastname: Cortet
authors.forename: P
authors.initials: P
authors.lastname: Bourel
authors.forename: P
authors.initials: P
authors.lastname: Dubois
authors.forename: N
authors.initials: N
authors.lastname: Boutry
authors.forename: A
authors.initials: A
authors.lastname: Cotten
authors.forename: X
authors.initials: X
authors.lastname: Marchandise
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000502:physiology; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology; D017697:Premenopause / Q000502:physiology; D014057:Tomography, X-Ray Computed