title: [Combination of cyclosporin and ketoconazole in immunosuppression schemes in patients with transplanted kidney].
abstract: Ketoconazole was used as an adjuvant to conventional 3-component immunosuppression in 56 patients with transplanted kidney. While receiving ketoconazole postoperative patients can be given reduced doses of cyclosporin (1.5-2 times). Long after the operation cyclosporin doses can be reduced 3-4-fold. Acute rejection occurred less frequently. This means that reduced cumulative steroid dose is needed for management of the rejection. In the dose above 100 mg/day, ketoconazole is able to enhance nephrotoxic effect of cyclosporin. A complication--acute renal dysfunction--is attributed to iatrogenic hypoaldosteronism induced by combination of large-dose cyclosporin + ketoconazole.
authors.forename: V S
authors.initials: VS
authors.lastname: Treĭvish
authors.forename: I N
authors.initials: IN
authors.lastname: Shoĭkhet
authors.forename: E V
authors.initials: EV
authors.lastname: Ankova
mesh_terms: D000208:Acute Disease; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016572:Cyclosporine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007654:Ketoconazole / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D007654:Ketoconazole
vernacular_title: O kombinirovanii tsiklosporina i ketokonazola v skhemakh immunocupressii u bol'nykh s peresazhennoĭ pochkoĭ.