title: Autoantibodies, autoimmunity and cancer (review).
abstract: There is a strong association between neoplasms and autoimmune diseases. Numerous autoimmune phenomena have been reported in malignancies and conversely: malignant tumors are diagnosed in increasing frequency in autoimmune conditions. We review the most common autoimmune diseases and autoantibodies found in malignancies, discuss the therapeutic role of these autoantibodies in cancer, and summarize the current knowledge on malignant transformation in autoimmunity.
authors.affiliation: Research Unit of Autoimmune Diseases and Department of Medicine, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Tomer
authors.forename: Y
authors.initials: Y
authors.lastname: Sherer
authors.forename: Y
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000912:Antibodies, Neoplasm / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology* / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy
chemical_list: D000912:Antibodies, Neoplasm; D001323:Autoantibodies