title: Radiographic, densitometric, and biomechanical effects of recombinant canine somatotropin in an unstable ostectomy gap model of bone healing in dogs.
abstract: OBJECTIVE
  To determine the effect of recombinant canine somatotropin (STH) on radiographic, densitometric, and biomechanical aspects of bone healing using an unstable ostectomy gap model.
  
  
  METHODS
  After an ostectomy of the midshaft radius, bone healing was evaluated over an 8-week period in control dogs (n = 4) and dogs receiving recombinant canine STH (n = 4).
  
  
  METHODS
  Eight sexually intact female Beagle dogs, 4 to 5 years old.
  
  
  METHODS
  Bone healing was evaluated by qualitative and quantitative evaluation of serial radiographs every 2 weeks. Terminal dual-energy x-ray absorptiometry and three-point bending biomechanical testing were also performed.
  
  
  RESULTS
  Dogs receiving STH had more advanced radiographic healing of ostectomy sites. Bone area, bone mineral content, and bone density were two to five times greater at the ostectomy sites of treated dogs. Ultimate load at failure and stiffness were three and five times greater in dogs receiving STH.
  
  
  CONCLUSIONS
  Using the ostectomy gap model, recombinant canine STH enhanced the radiographic, densitometric, and biomechanical aspects of bone healing in dogs.
  
  
  CONCLUSIONS
  Dogs at risk for delayed healing of fractures may benefit from treatment with recombinant canine STH.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Tennessee, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Millis
authors.forename: B E
authors.initials: BE
authors.lastname: Wilkens
authors.forename: G B
authors.initials: GB
authors.lastname: Daniel
authors.forename: K
authors.initials: K
authors.lastname: Hubner
authors.forename: A
authors.initials: A
authors.lastname: Mathews
authors.forename: F C
authors.initials: FC
authors.lastname: Buonomo
authors.forename: K R
authors.initials: KR
authors.lastname: Patell
authors.forename: J P
authors.initials: JP
authors.lastname: Weigel
mesh_terms: D015502:Absorptiometry, Photon / Q000662:veterinary; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D004285:Dogs / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000235:genetics / Q000494:pharmacology*; D010027:Osteotomy / Q000662:veterinary; D011884:Radius / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000601:surgery; D011897:Random Allocation; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone