Blockade of morphine- and amphetamine-induced conditioned place preference in the rat by riluzole.
Previous studies have shown that antagonists at glutamatergic N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid (AMPA) receptors can disrupt the development or expression, respectively, of conditioned place preference (CPP) induced by drugs of abuse. The present study examined the effects of inhibition of presynaptic glutamate release by riluzole on the development of morphine- and amphetamine-induced CPP. Morphine (10 mg/kg), D,L-amphetamine (4 mg/kg) and riluzole (4 mg/kg) itself each produced a significant CPP; however, when riluzole was co-administered with morphine or amphetamine during the conditioning sessions, no CPP developed. It is concluded that non-specific disruption of glutamatergic neurotransmission prevents the development of morphine- and amphetamine-induced CPP.
Tzschentke
T M
TM
Department of Neuropharmacology, Zoological Institute, University of Tübingen, Germany. thomas.tzschentke@uni-tuebingen.de
Schmidt
W J
WJ
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D019782:Riluzole / Q000494:pharmacology*; D019966:Substance-Related Disorders / Q000188:drug therapy
D000697:Central Nervous System Stimulants; D018691:Excitatory Amino Acid Antagonists; D009294:Narcotics; D018698:Glutamic Acid; D009020:Morphine; D019782:Riluzole; D000661:Amphetamine