title: Helicases: a unifying structural theme?
abstract: The recent structure determinations of PcrA DNA helicase, NS3 RNA helicase, and Rep DNA helicase have revealed similarities between their folds. When these data are examined with sequence and biochemical analyses, as well as microscopy studies of hexameric helicases, a picture of a unifying structure and mechanism for all helicases is beginning to emerge.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: L E
authors.initials: LE
authors.lastname: Bird
authors.forename: H S
authors.initials: HS
authors.lastname: Subramanya
authors.forename: D B
authors.initials: DB
authors.lastname: Wigley
mesh_terms: D004247:DNA / Q000378:metabolism; D004265:DNA Helicases / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D008958:Models, Molecular; D017510:Protein Folding; D013329:Structure-Activity Relationship
chemical_list: D004247:DNA; D004265:DNA Helicases