Effects of intra-abdominal hypertension on hepatic energy metabolism in a rabbit model.
BACKGROUND
Intra-abdominal hypertension is known to decrease hepatic blood flow, but its effect on hepatic energy level has not described.


METHODS
Fifty-three rabbits were mechanically ventilated and divided into five groups. Intra-abdominal hypertension was induced by saline infusion and maintained for 30 minutes. Hepatic sinusoidal functional blood flow was evaluated by means of indocyanine green disappearance rate (ICG-K), hepatic mitochondrial redox status was evaluated by arterial ketone body ratio, and tissue energy level was evaluated by energy charge (EC).


RESULTS
At an intra-abdominal pressure of 20 mm Hg, ICG-K was significantly decreased, with no decrease in EC. At 30 mm Hg, hypoxemia developed and the ICG-K decreased further, with significant decreases observed in arterial ketone body ratio and EC. The latter were not increased by administration of oxygen.


CONCLUSIONS
At an intra-abdominal pressure of 20 mm Hg, a slight decrease in sinusoidal flow did not affect hepatic energy level. At 30 mm Hg, a reduced hepatic mitochondrial redox status and a decreased energy level were attributed to a decrease in sinusoidal flow in this animal model.
Nakatani
T
T
Trauma and Critical Care Center, Teikyo University School of Medicine, Itabashi, Tokyo, Japan.
Sakamoto
Y
Y
Kaneko
I
I
Ando
H
H
Kobayashi
K
K
D000005:Abdomen; D000818:Animals; D001783:Blood Flow Velocity; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D004734:Energy Metabolism; D006973:Hypertension / Q000150:complications*; D000860:Hypoxia / Q000209:etiology; D007511:Ischemia / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D007659:Ketones / Q000097:blood; D008099:Liver / Q000098:blood supply*; D008102:Liver Circulation; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D011817:Rabbits
D007659:Ketones