title: A novel DRB1*0801 haplotype carrying DRB3*0202 found in a German pedigree.
abstract: DRB1*08 haplotypes have not been known to carry a DRB3 gene. We have found a patient suffering from liver disease who has a novel HLA haplotype of DRB1*0801 with DRB3*0202 as established by family segregation. These two genes were confirmed by sequencing. DR8 and DR52 antigen specificities were serologically detected, indicating expression of these genes.
authors.affiliation: Blutbank-Immunhämatologie-Transfusionsmedizin, Medizinische Hochschule Hannover, Germany.
authors.forename: D F
authors.initials: DF
authors.lastname: Chen
authors.forename: L T
authors.initials: LT
authors.lastname: Pastucha
authors.forename: E D
authors.initials: ED
authors.lastname: Albert
authors.forename: I
authors.initials: I
authors.lastname: Seibert
authors.forename: A
authors.initials: A
authors.lastname: Volgger
authors.forename: Z
authors.initials: Z
authors.lastname: Yao
authors.forename: C D
authors.initials: CD
authors.lastname: Pein
authors.forename: H L
authors.initials: HL
authors.lastname: Tillmann
authors.forename: M P
authors.initials: MP
authors.lastname: Manns
authors.forename: W
authors.initials: W
authors.lastname: Stangel
mesh_terms: D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics; D005858:Germany; D006684:HLA-DR Antigens / Q000032:analysis / Q000097:blood / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008107:Liver Diseases / Q000235:genetics / Q000276:immunology; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA
chemical_list: D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C041559:HLA-DR8 antigen; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains