Effect of repeated oral infection of hamsters with scrapie.
The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.
Diringer
H
H
Robert Koch-Institut, Bundesinstitut für Infektionskrankheiten und nicht übertragbare Krankheiten, Berlin, Germany.
Roehmel
J
J
Beekes
M
M
D000284:Administration, Oral; D000818:Animals; D006224:Cricetinae; D004334:Drug Administration Schedule; D007267:Injections; D012608:Scrapie / Q000209:etiology* / Q000401:mortality