title: Fmoc/Trt-amino acids: comparison to Fmoc/tBu-amino acids in peptide synthesis.
abstract: Model peptides containing the nucleophilic amino acids Trp and Met have been synthesized with the application of Fmoc/Trt- and Fmoc/tBu-amino acids, for comparison. The deprotection of the peptides synthesized using Fmoc/Trt-amino acids in all cases leads to crude peptides of higher purity than that of the same peptides synthesized using Fmoc/tBu-amino acids.
authors.affiliation: Department of Chemistry, University of Patras, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Barlos
authors.forename: D
authors.initials: D
authors.lastname: Gatos
authors.forename: S
authors.initials: S
authors.lastname: Koutsogianni
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005449:Fluorenes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010455:Peptides