title: Comparative study of air coagulation, fibrin sealant, and suture in experimental liver injury.
abstract: OBJECTIVE
  To test the effects of hot air coagulation, fibrin sealant, and horizontal mattress sutures on haemostasis and regeneration in experimental hepatectomy.
  
  
  METHODS
  Randomised laboratory experiment.
  
  
  METHODS
  Teaching hospital, Spain.
  
  
  METHODS
  200 rats divided into four groups (three experimental [n=60 in each] and one control [n=20]).
  
  
  METHODS
  Hepatic injuries were repaired by suture, coagulation, or fibrin sealant in the three experimental groups. The control group was used only to supply baseline blood samples. 10 animals in each experimental group were killed at 3, 5, 10, 25, 40, and 60 days.
  
  
  METHODS
  Time taken to achieve haemostasis, and histopathological scores of healing.
  
  
  RESULTS
  Mattress sutures took mean (SEM) of 346 (7) seconds to control the haemorrhage and allow the liver to regain its shape and 4 rats developed abscesses (7%). Fibrin sealant achieved haemostasis immediately and the liver regained its shape in 58 (2) seconds; 2 rats (3%) developed abscesses. Hot air coagulation achieved haemostasis in 27 (1) seconds and there were no abscesses.
  
  
  CONCLUSIONS
  Fibrin sealant was the best technique because it achieved immediate haemostasis and speedy regeneration. However, hot air coagulation is a useful and cheaper alternative.
authors.affiliation: Departamento de Patología Animal, Unidad de Cirugía, Facultad de Veterinaria, Universidad de Murcia, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Tovar
authors.forename: M A
authors.initials: MA
authors.lastname: Sanchez-Valverde
authors.forename: A
authors.initials: A
authors.lastname: Agut
authors.forename: F G
authors.initials: FG
authors.lastname: Laredo
authors.forename: J
authors.initials: J
authors.lastname: Murciano
mesh_terms: D000818:Animals; D005069:Evaluation Studies as Topic; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use*; D006498:Hepatectomy; D008115:Liver Regeneration; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques; D014945:Wound Healing
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics