title: [The neuropathies of IgM monoclonal gammopathies].
abstract: A peripheral polyneuropathy is often associated with an IgM monoclonal gammapathy. The monoclonal protein often binds to carbohydrate epitopes on glycoproteins and/or glycolipids of the human peripheral nerve. The clinical syndrome is related to the antigen-specificity of the IgM protein. Detection of anti-myelin antibodies and further characterization of their immunogenic specificity provide an important aid in the differential diagnosis of late-onset chronic polyneuropathies.
authors.affiliation: Laboratoire d'Immunopathologie, Centre Hospitalier de Luxembourg.
authors.forename: R L
authors.initials: RL
authors.lastname: Humbel
authors.forename: P
authors.initials: P
authors.lastname: Schmit
authors.forename: G
authors.initials: G
authors.lastname: Gilson
mesh_terms: D006017:Glycolipids / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology
chemical_list: D006017:Glycolipids; D007075:Immunoglobulin M
vernacular_title: Les neuropathies des gammapathies monoclonales a IgM.