Severe hypotension associated with angiotensin-converting enzyme inhibition in anaesthesia.
Three cases of severe hypotension associated with the use of angiotensin-converting enzyme inhibitors (ACEIs) and intravenous administration of the synthetic colloid Gelofusin (Braun Medical Ltd) are presented. A possible mechanism of interaction between ACEIs and Gelofusin is discussed. All three patients were treated successfully.
Powell
C G
CG
Department of Anaesthesia and Immunology, Southmead Hospital, Westbury-on-Trym,, Bristol, United Kingdom.
Unsworth
D J
DJ
McVey
F K
FK
D000368:Aged; D000758:Anesthesia; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D001810:Blood Volume / Q000187:drug effects; D005260:Female; D005780:Gelatin / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology; D010952:Plasma Substitutes / Q000009:adverse effects*; D013386:Succinates / Q000009:adverse effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010952:Plasma Substitutes; D013386:Succinates; C060085:succinylated gelatin; D005780:Gelatin