title: [NO synthetase in the cells of different tissues and organs of the mouse].
abstract: Cellular NO synthase was assayed in bone marrow, spleen, thymus, lymph nodes, epidermis, hypodermic connective tissue, small gut, peritoneal exudate, liver, kidney, and heart by cytochemical and immunofluorescent methods. As a rule the enzymatic activity was found in differentiated cells that finished proliferation (mature hemopoietic cells, epithelium of gut villi, etc.). The enzyme activity was undetectable in actively reproducing low-differentiated cells (basal layer of the epidermis, crypt cells of the small gut, or blast hemopoietic forms). NO is proposed to participate in regulation of tissue-specific terminal differentiation (maturation) of the cells.
authors.affiliation: Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Vasil'eva
authors.forename: T V
authors.initials: TV
authors.lastname: Michurina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Radionova
authors.forename: B A
authors.initials: BA
authors.lastname: Kuzin
authors.forename: G N
authors.initials: GN
authors.lastname: Enikolopov
authors.forename: N G
authors.initials: NG
authors.lastname: Khrushchov
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019084:Fluorescent Antibody Technique, Indirect; D006651:Histocytochemistry; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D019001:Nitric Oxide Synthase / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D019001:Nitric Oxide Synthase
vernacular_title: Issledovanie NO-sintetazy v kletkakh razlichnykh tkaneĭ i organov myshi.