In vitro activity of BAY 12-8039, a new fluoroquinolone against mycoplasmas.
The in vitro activity of the fluoroquinolone BAY 12-8039 against 66 strains of different mycoplasma species and 30 strains of Ureaplasma urealyticum was compared with those of three other antimicrobial agents. BAY 12-8039 at 0.5 microg/ml inhibited 100% of all the mycoplasmal and ureaplasmal strains tested. The minimal bactericidal concentrations of BAY 12-8039 increased only two- to eightfold compared to the MICs. Furthermore, they were comparable to those of sparfloxacin and lower than those of doxycycline and clarithromycin.
Bébéar
C M
CM
Laboratoire de Bactériologie, Université de Bordeaux 2, France. cecile.bebear@labbebear.u-bordeaux2.fr
Renaudin
H
H
Boudjadja
A
A
Bébéar
C
C
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009174:Mycoplasma / Q000187:drug effects*; D011804:Quinolines; D015363:Quinolones / Q000494:pharmacology*; D016990:Ureaplasma urealyticum / Q000187:drug effects*
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D015363:Quinolones; D000077266:Moxifloxacin