title: Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants.
abstract: Three dogs became lethargic and had poor appetites within 2 months after anticonvulsant treatment was initiated to control seizures. Dogs were neutropenic, thrombocytopenic, and anemic and had splenomegaly. Sensitivity to phenobarbital and related anticonvulsants may induce life-threatening leukopenia, thrombocytopenia, and anemia in dogs. Phenobarbital-induced neutropenia in these 3 dogs may have posed a risk for developing bacteremia. It is important for clinicians to be aware of adverse effects so that adequate precautions can be taken. A baseline hemogram should always be obtained before starting anticonvulsant treatment, and periodic hemograms should be obtained to monitor animals. Furthermore, client education should include instructions on recognizing signs of bacteremia, thrombocytopenia, and anemia.
authors.affiliation: Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
authors.forename: G
authors.initials: G
authors.lastname: Jacobs
authors.forename: C
authors.initials: C
authors.lastname: Calvert
authors.forename: A
authors.initials: A
authors.lastname: Kaufman
mesh_terms: D000740:Anemia / Q000139:chemically induced / Q000662:veterinary; D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D016470:Bacteremia / Q000209:etiology / Q000662:veterinary; D001772:Blood Cell Count / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D010634:Phenobarbital / Q000009:adverse effects* / Q000627:therapeutic use; D011324:Primidone / Q000009:adverse effects* / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000662:veterinary; D013921:Thrombocytopenia / Q000139:chemically induced / Q000662:veterinary*
chemical_list: D000927:Anticonvulsants; D011324:Primidone; D010634:Phenobarbital