title: Vertebral osteomyelitis due to Rhodococcus equi in a liver transplant recipient.
abstract: Rhodococcus equi is a rare but well-documented cause of cavitary pneumonia in immunocompromised patients. In this report the first case of R. equi infection manifesting as vertebral osteomyelitis is described. A 39-year-old liver transplant recipient presented with recurrent pneumonia and a pleura-based lung abscess and subsequently developed osteomyelitis of the lower thoracic spine. Surgical debridement and prolonged treatment with rifabutin and clarithromycin resulted in clinical cure. In the literature, 12 other cases of R. equi infection in solid-organ transplant recipients have been reported. Ten of these patients had documented pulmonary disease and seven had extrapulmonary manifestations. Prolonged antibiotic therapy and surgical drainage resulted in clinical improvement in > 90% of the reported cases.
authors.affiliation: Department of Surgery, University Hospital Eppendorf, Hamburg, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Fischer
authors.forename: M
authors.initials: M
authors.lastname: Sterneck
authors.forename: H
authors.initials: H
authors.lastname: Albrecht
authors.forename: G
authors.initials: G
authors.lastname: Krupski
authors.forename: S
authors.initials: S
authors.lastname: Polywka
authors.forename: X
authors.initials: X
authors.lastname: Rogiers
authors.forename: C E
authors.initials: CE
authors.lastname: Broelsch
mesh_terms: D000193:Actinomycetales Infections / Q000188:drug therapy / Q000382:microbiology*; D000328:Adult; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology*; D016929:Rhodococcus equi; D013122:Spinal Diseases; D013904:Thoracic Vertebrae / Q000382:microbiology*