title: The significance of oncometry for infusion therapy during pediatric heart surgery.
abstract: BACKGROUND
  The colloid osmotic pressure (COP) is not routinely assessed during pediatric heart surgery. Two cases of unrecognized hyperoncotic states associated with renal failure have been observed after pediatric heart surgery. We studied the hypothesis that the COP cannot be estimated from the total plasma protein (TPP) or albumin level.
  
  
  METHODS
  The course of COP and its correlation to the TPP and albumin level were investigated in 25 children undergoing elective heart surgery. Infusion therapy was performed solely on the basis of clinical parameters and TPP/albumin levels. COP values were determined in a blinded fashion at the end of the study.
  
  
  RESULTS
  No correlation between TPP/albumin and the COP could be determined preoperatively. On arrival at the ICU correlation was strong. A weak correlation was observed at 24 hours and 48 hours after surgery. However, the observed wide range of the confidential bands indicates that the COP cannot be estimated correctly, neither from the TPP, nor from the albumin level. Due to colloidal oversubstitution COP was significantly increased compared to preoperative level at 48 hrs following surgery.
  
  
  CONCLUSIONS
  As estimation of COP from TPP or albumin level is inaccurate, oncometry should be performed during pediatric heart surgery.
authors.affiliation: Department of Cardiovascular Surgery, University of Cologne, Medical Center, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Bartels
authors.forename: B
authors.initials: B
authors.lastname: Hadzik
authors.forename: M
authors.initials: M
authors.lastname: Abel
authors.forename: B
authors.initials: B
authors.lastname: Roth
authors.forename: C
authors.initials: C
authors.lastname: Diefenbach
authors.forename: R
authors.initials: R
authors.lastname: De Vivie
mesh_terms: D001798:Blood Proteins / Q000032:analysis*; D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D005260:Female; D005440:Fluid Therapy; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods*; D009997:Osmotic Pressure; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin