Potential anxiolytic-like activity of some amino acid derivatives.
Three derivatives of amino acids: (R)-Ac-Pro-BZA (1), Ac-beta Ala-BZA (2) and (S)-Ac-Arg(NO2)-BZA (3) were evaluated as potential anxiolytics. In the conflict drinking test in rats used as a model of anxiety, the tested compounds exhibited anxiolytic-like activity. Compounds 1 and 2 administered in doses of 50-100 mg/kg produced an anticonflict effect in a dose-dependent manner. A distinct effect is observed after dose of 100 mg/kg of 1 and 2, comparable to those induced by 10 mg/kg of diazepam. The anticonflict effect of 3 was weak and dose independent. It was revealed only in one mean dose (50 mg/kg) but not in the higher doses.
Paruszewski
R
R
Department of Drug Chemistry, Medical University, Warszawa, Poland.
Kłodzińska
A
A
Chojnacka-Wójcik
E
E
D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects; D004597:Electroshock; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D003975:Diazepam