title: Oxfendazole treatment for cystic hydatid disease in naturally infected animals.
abstract: Few chemotherapeutic agents are available for the medical management of hydatid disease caused by the parasite Echinococcus granulosus. In order to test the potential of oxfendazole for the treatment of infection with this parasite, nine infected goats and four sheep were given oxfendazole twice weekly at a dose of 30 mg/kg of body weight for 4 weeks and monitored by ultrasound for an additional 4 weeks. Efficacy was finally evaluated by postmortem examination, including determination of protoscolex viability and cyst wall histology. In treated animals, protoscolices were dead or absent in 97% of cysts from oxfendazole-treated animals compared to 28% of cysts from untreated control animals. On postmortem examination, 53% of cysts from treated animals were found to be grossly degenerate. A sample of those cysts that appeared potentially viable all demonstrated evidence of severe damage to the cyst wall. By light microscopy, cysts showed severe disorganization of the adventitial layer with invasion of inflammatory cells and in some cases frank necrosis with no apparent adventitial layer. The follow-up period for assessment of the drug's ability to cause complete degeneration and resorption of cysts was relatively short. This study, however, indicates that oxfendazole is at least as effective as and is easier to administer than albendazole for the treatment of hydatid disease.
authors.affiliation: Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland, Ohio 44106, USA. reb6@po.cwru.edu
authors.forename: R E
authors.initials: RE
authors.lastname: Blanton
authors.forename: T M
authors.initials: TM
authors.lastname: Wachira
authors.forename: E E
authors.initials: EE
authors.lastname: Zeyhle
authors.forename: E M
authors.initials: EM
authors.lastname: Njoroge
authors.forename: J K
authors.initials: JK
authors.lastname: Magambo
authors.forename: P M
authors.initials: PM
authors.lastname: Schantz
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D004443:Echinococcosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D004446:Echinococcus / Q000187:drug effects*; D015511:Goat Diseases / Q000188:drug therapy*; D006041:Goats; D008099:Liver / Q000000981:diagnostic imaging / Q000469:parasitology; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; C011030:oxfendazole