title: Successful treatment of disseminated coccidioidomycosis with amphotericin B lipid complex.
abstract: Coccidioidomycosis is endemic in regions of the Americas, but this infection may be encountered in travellers who return from an endemic region. A case is reported of a disseminated infection in a Hong Kong Chinese man, who was successfully treated with amphotericin B lipid complex (ABLC) after intolerance and toxicity precluded the use of other antifungal agents. Lipid-based formulations of amphotericin B merit further evaluation in the treatment of coccidioidomycosis and other systemic mycoses.
authors.affiliation: Department of Microbiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories.
authors.forename: A P
authors.initials: AP
authors.lastname: Koehler
authors.forename: A F
authors.initials: AF
authors.lastname: Cheng
authors.forename: K C
authors.initials: KC
authors.lastname: Chu
authors.forename: C H
authors.initials: CH
authors.lastname: Chan
authors.forename: A S
authors.initials: AS
authors.lastname: Ho
authors.forename: D J
authors.initials: DJ
authors.lastname: Lyon
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D003047:Coccidioidomycosis / Q000188:drug therapy* / Q000635:transmission; D004338:Drug Combinations; D006801:Humans; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D010715:Phosphatidylglycerols / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D000666:Amphotericin B