title: [Salmonella meningitis in children in Libreville. Retrospective study of 9 cases].
abstract: BACKGROUND
  Salmonella meningitis is a rare entity, even in tropical area where salmonellosis is common. Its prognosis is poor and the choice of adequate antibiotic therapy is difficult.
  
  
  METHODS
  The files of nine children (three boys, six girls) admitted to the pediatric unit of the Owendo Pediatric Hospital in Libreville for salmonella meningitis between January 1, 1989, and December 31, 1993 were retrospectively studied. Diagnosis was established by a positive culture of cerebrospinal fluid.
  
  
  RESULTS
  Salmonella was the third cause (8.65%) of purulent meningitis observed during this period. Eight children were less than 1-year old, seven were from low socioeconomic standard families. The main clinical manifestations were fever (seven cases), pallor (six cases), diarrhea (four cases), nuchal rigidity (four cases), convulsions (three cases) and bulging fontanel (three cases). Five children (55.5%) were severely anemic (hemoglobin < 5 g/dL) but none had abnormal hemoglobin. Serotyping could not be performed in any case. Salmonella isolates were resistant to chloramphenicol in six cases and to ampicillin in five. Cefotaxime (200 mg/kg/24 h intravenously in three divided doses) was given to seven patients. The duration of therapy was at least 3 weeks in four patients. There were five deaths at ages ranging from 1 to 12 months, ie, a case fatality rate of 55.5%. Three patients (33.3%) recovered with neurological sequels.
  
  
  CONCLUSIONS
  The prognosis of salmonella meningitis is poor, even in the case of prompt diagnosis and adequate therapy. Preventive measures only can decrease the risk of illness in children.
authors.affiliation: Service de pédiatrie générale, hôpital pédiatrique d'Owendo, Libreville, Gabon.
authors.forename: J
authors.initials: J
authors.lastname: Koko
authors.forename: D
authors.initials: D
authors.lastname: Dufillot
authors.forename: F
authors.initials: F
authors.lastname: Kani
authors.forename: D
authors.initials: D
authors.lastname: Gahouma
authors.forename: A
authors.initials: A
authors.lastname: Reymond-Yeni
mesh_terms: D002439:Cefotaxime / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005681:Gabon / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D012189:Retrospective Studies; D012480:Salmonella Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D002511:Cephalosporins; D002439:Cefotaxime
vernacular_title: M eningites à salmonelles de l'enfant à Libreville. Etude rétrospective de neuf observations.