title: Significance of intraperitoneal cytology in patients undergoing radical hysterectomy.
abstract: The incidence and prognostic significance of positive intraperitoneal cytology taken during a radical hysterectomy was reviewed. A prospective study looking at intraperitoneal cytology was conducted by using 400 consecutive radical hysterectomies from January 1988 through June 1996. All selected patients had peritoneal washings performed prior to a radical hysterectomy with pelvic and para-aortic lymphadenectomy. A single pathologist reviewed all cytological and histologic specimens. A total of 400 patients were included in the study. Only 7 of 400 (1.8%) had positive intraperitoneal cytology. Four had squamous cell cancer and 3 had adenocarcinoma. Five had stage IB cervical cancer and the remainder were stage IIA. Three had positive nodes. Six of 7 had tumor size greater than 3 cm. Three of 7 had > 50% invasion and 2 of 7 had lymphovascular space invasion. No other risk factors were present in these specimens. Six of 7 recurred within 18 months of surgery. Recurrences were local or retroperitoneal; none were upper abdomen or intraperitoneal. The incidence of positive peritoneal cytology during radical hysterectomy is 1.8%. The cost of these cytology specimens did not offer an advantage to the current surgical-pathological factors used to determine prognosis and adjuvant therapy.
authors.affiliation: Department of Gynecologic Oncology, University of Miami/Jackson Memorial Hospital, FL 33136, USA.
authors.forename: R
authors.initials: R
authors.lastname: Estape
authors.forename: R
authors.initials: R
authors.lastname: Angioli
authors.forename: F
authors.initials: F
authors.lastname: Wagman
authors.forename: M
authors.initials: M
authors.lastname: Madrigal
authors.forename: M
authors.initials: M
authors.lastname: Janicek
authors.forename: P
authors.initials: P
authors.lastname: Ganjei-Azar
authors.forename: M
authors.initials: M
authors.lastname: Penalver
authors.forename: H
authors.initials: H
authors.lastname: Averette
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000556:secondary*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000556:secondary*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008207:Lymphatic Metastasis; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D010534:Peritoneal Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D011379:Prognosis; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant