Hepatoprotective activity of phenylethanoids from Cistanche deserticola.
Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D-GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.
Xiong
Q
Q
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
Hase
K
K
Tezuka
Y
Y
Tani
T
T
Namba
T
T
Kadota
S
S
D000818:Animals; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008516:Medicine, Chinese Traditional; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D010636:Phenols; D010936:Plant Extracts; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D059808:Polyphenols
D002251:Carbon Tetrachloride; D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; C111522:2'-acetylacteoside; C111523:tubuloside B; C058956:acteoside; D059808:Polyphenols; C064683:isoacteoside