title: [Effect of hydroxyapatite layering on the osteo-integration of weightbearing and non-weightbearing implants. Comparison to other microporous surfaces in animal experiments].
abstract: In case of non cemented fixation of prosthesis an extensive osseointegration is a precondition to obtain long lasting biological anchorage of the implant. The aim of the presented study was to analyse, whether the use of biactive materials (in case of prostheses-hydroxylapatit-coating-) provides advantages concerning the quality of anchorage compared to biotolerant or bionert materials. The influence of grade of biocompatibility of materials, the surface structure, the period of investigation and weightbearing on the osseointegration of implants was evaluated in an animal experimental study. New Zealand White rabbits got implanted cylinders in the non weightbearing series and spacers in the weightbearing series in the distal femur. The implant materials were spongy metal, porous coated titanium and hydroxylapatit coated titanium. After the experimental period of 4, 8 respectively 12 weeks the implant bearing femur underwent histological, morphometrical and scanning electromicroscopical investigation. The amount of osseointegration was determined by using the automatical image analysis. The percentage of new build bone was investigated by fluorescence microscopy and the adhesive power by push out tests. For non weightbearing implants higher adhesive powers were measured compared to hydroxylapatit coated implants while osseointegration was identic. All primary press-fit anchored weightbearing implants showed osseointegration. In hydroxylapatit coated specimen the most intensive osseointegration was found however without influence on the adhesive power. This fact was caused by the delamination of the plasma coating as consequence of the insufficient attachment of the hydroxylapatit coat to the metal nucleus.
authors.affiliation: Sana-Klinik Zollernalb GmbH, Albstadt.
authors.forename: B
authors.initials: B
authors.lastname: Gondolph-Zink
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes; D016025:Bone Transplantation; D017886:Durapatite; D005269:Femur / Q000601:surgery; D006801:Humans; D019919:Prosthesis Implantation; D011817:Rabbits; D014025:Titanium; D016474:Weight-Bearing
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D017886:Durapatite; D014025:Titanium
vernacular_title: Der Einfluss der Hydroxylapatitbeschichtung auf die Osteointegration belasteter und unbelasteter Implantate. Vergleich zu anderen mikroporösen Oberflächenstrukturierungen im Tierexperiment.