title: Effect of norethindrone acetate in the treatment of symptomatic endometriosis.
abstract: OBJECTIVE
  The purpose of the study was to evaluate the efficacy of norethindrone acetate (NA) treatment in 52 women with dysmenorrhea, dyspareunia, noncyclic pelvic pain who had a diagnosis of endometriosis by laparoscopy.
  
  
  RESULTS
  Dysmenorrhea and noncyclic pelvic pain were relieved in 48/52 (92.3%) and 25/28 (89.2%) of patients, respectively. Overall pain relief was obtained in 49/52 (94.2%) of patients. Breakthrough bleeding, of variable severity, was the most common side effect experienced by 30 patients (57.6%); however, only 4 patients (7.7%) dropped out for this side effect. One other patient dropped out for severe breast tenderness, and three for noncyclic pelvic pain. In general, treatment was successful in 44/52 (84.5%) of patients with the above symptoms.
  
  
  CONCLUSIONS
  NA seems to be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, SUNY/Health Science Center at Brooklyn, USA.
authors.forename: O
authors.initials: O
authors.lastname: Muneyyirci-Delale
authors.forename: M
authors.initials: M
authors.lastname: Karacan
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009640:Norethindrone / Q000009:adverse effects / Q000627:therapeutic use*; D010352:Patient Dropouts; D045167:Progesterone Congeners / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000139:chemically induced
chemical_list: D045167:Progesterone Congeners; D009640:Norethindrone