Effects of dopamine hydrochloride (Inovan(R)) on ouabain-sensitive, K+-dependent, p-nitrophenylphosphatase activity of choroid plexus in guinea pigs.
Dopamine hydrochloride (Inovan(R)) is used for the treatment of acute circulatory insufficiency. In the present study, the Na-K ATPase activity of the choroid plexus was determined normal and after repeated injections of dopamine hydrochloride using cerium-based cytochemistry. In the normal guinea pigs, the reaction product was detected on the microvilli of the choroidal epithelium, but was almost undetectable after seven repeated injections of dopamine hydrochloride. These findings suggested that high doses of dopamine hydrochloride decreased the choroidal Na-K ATPase activity.
Kanoh
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Department of Otolaryngology, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo 663, Japan.
D009597:4-Nitrophenylphosphatase / Q000187:drug effects*; D000818:Animals; D002831:Choroid Plexus / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D010042:Ouabain / Q000494:pharmacology*
D010042:Ouabain; D009597:4-Nitrophenylphosphatase; D004298:Dopamine