[Mixed uterine mesodermal sarcoma in the population of southern Israel in the years 1996-1971--clinical and pathological characteristics].
During 1971-1996, 17 patients with mixed mesodermal uterine tumors were treated. Average age at diagnosis was 67.3 years, 12/17 were of European and 5/17 of Afro-Asian extraction. The overall 5-year survival was 21%. 10/17 patients had mixed mesodermal tumors with a heterologous mesenchymal element, and 7/17 had a homologous mesenchymal element (carcinosarcoma). 6/17 had another primary malignancy, including breast cancer (3/17), bilateral metachronous breast tumor (2/17), and malignant lymphoma of the neck region (2/17). All 3 with breast cancer had previously been treated with tamoxifen. I had simultaneous mesodermal tumor and ovarian thecoma. Simultaneous autoimmune manifestations occurred in 2/17, including thrombocytopenic purpura in 1, and myasthenia gravis in another. Mesodermal tumor of the uterus is a relatively rare malignancy with aggressive behavior and poor prognosis. It also had unusual associations with other primary tumors, hormonal treatment, and autoimmune manifestations.
Ariad
S
S
Dept. of Oncology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheba.
Rabinovitz
A
A
Yanai-Inbar
I
I
Piura
B
B
D000368:Aged; D003710:Demography; D005260:Female; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008875:Middle Aged; D018199:Mixed Tumor, Mesodermal / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D016609:Neoplasms, Second Primary / Q000453:epidemiology; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology