Increased tolerance to vecuronium in a patient with testicular feminization.
Muscle relaxant pharmacophysiology can be altered in various clinical situations. We report increased requirement of vecuronium in a patient diagnosed with testicular feminization. Increased level of endogenous testosterone and steroidal-core structure of vecuronium may explain the increased tolerance to vecuronium in this patient.
Lee
H T
HT
Department of Anesthesiology, College of Physicians & Surgeons of Columbia University, New York, NY, USA.
Appel
M I
MI
D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000150:complications*; D000768:Anesthesia, General; D005260:Female; D006801:Humans; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage; D013739:Testosterone / Q000097:blood / Q000737:chemistry; D014673:Vecuronium Bromide / Q000008:administration & dosage / Q000737:chemistry
D003473:Neuromuscular Nondepolarizing Agents; D013739:Testosterone; D014673:Vecuronium Bromide