title: Recurrent phyllodes tumor in a man.
abstract: The case of a 35-year-old man with a borderline-type cystosarcoma phyllodes is presented. Four years after the primary excision of the tumor, wide excision of a local recurrence and postoperative radiotherapy were performed. No repeated relapse was observed during a 5-year follow-up. Neither significant endocrine changes nor genetic alteration could be proven. However, a slightly increased SHBG concentration was detected, resulting in a decreased biologically available androgen level reduced testosterone/SHBG index. This phenomenon might be a consequence of the chronic liver disease of the patient due to his type II diabetes mellitus and alcohol abuse. In addition to the conventional histopathological examinations, immunohistochemical and electron-microscopic investigations were carried out on tissue sections, and the steroid receptors, EGF receptors and EGF-like activity of the tumor were also studied.
authors.affiliation: Department of Oncotherapy, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Kahán
authors.forename: A M
authors.initials: AM
authors.lastname: Tószegi
authors.forename: F
authors.initials: F
authors.lastname: Szarvas
authors.forename: G
authors.initials: G
authors.lastname: Gaizer
authors.forename: G
authors.initials: G
authors.lastname: Baradnay
authors.forename: J
authors.initials: J
authors.lastname: Ormos
mesh_terms: D000328:Adult; D018567:Breast Neoplasms, Male / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D012739:Gonadal Steroid Hormones / Q000032:analysis; D006801:Humans; D008297:Male; D003557:Phyllodes Tumor / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D010908:Pituitary Hormones, Anterior / Q000032:analysis; D013963:Thyroid Hormones / Q000032:analysis
chemical_list: D012739:Gonadal Steroid Hormones; D010908:Pituitary Hormones, Anterior; D013963:Thyroid Hormones