title: Transarterial embolization of the uterine arteries: patient reactions and effects on uterine vasculature.
abstract: BACKGROUND
  Therapeutic embolization of the uterine arteries has been successfully used to manage profuse gynecological hemorrhage. In the present study we aimed to investigate whether embolization of uterine arteries may serve as a safe and effective alternative treatment in cases of menorrhagia in fertile and perimenopausal women. As a first step, we have evaluated the methodology, patient reactions and effects on the uterine vasculature.
  
  
  METHODS
  The distal part of the uterine artery was embolized with polyvinyl alcohol particles via catheterization of the right femoral artery. Total abdominal hysterectomy was performed the next day.
  
  
  RESULTS
  Bilateral embolization in two patients resulted in considerable pain that required morphine analgesic medication and epidural analgesia. One patient was embolized unilaterally and experienced only slight discomfort with no need for analgesic medication at all, indicating that unilateral embolization is a well-tolerated method. After embolization, angiography showed stagnant flow in embolized vessels without contrast filling of distal branches. Angiography of the specimen showed normal vascular architecture in non-treated vessels. In treated vessels the main arterial trunks were patent but all smaller branches were occluded. Histology showed that most of the particles lodged in small arteries and that arterioles never showed injected material.
  
  
  CONCLUSIONS
  The study indicates that the procedure involves an efficient occlusion of uterine vessels and that unilateral embolization of uterine arteries is well tolerated.
authors.affiliation: Department of Obstetrics & Gynaecology, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Aziz
authors.forename: O M
authors.initials: OM
authors.lastname: Petrucco
authors.forename: S
authors.initials: S
authors.lastname: Makinoda
authors.forename: G
authors.initials: G
authors.lastname: Wikholm
authors.forename: P
authors.initials: P
authors.lastname: Svendsen
authors.forename: M
authors.initials: M
authors.lastname: Brännström
authors.forename: P O
authors.initials: PO
authors.lastname: Janson
mesh_terms: D000328:Adult; D000792:Angiography; D001158:Arteries; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000628:therapy*; D008875:Middle Aged; D011142:Polyvinyl Alcohol; D014591:Uterine Diseases / Q000628:therapy*; D014599:Uterus / Q000098:blood supply*
chemical_list: D011142:Polyvinyl Alcohol