title: Antidepressant activity of new hetero[2,1]benzothiazepine derivatives.
abstract: A number of thieno and pyrazolo[2,1]benzothiazepine derivatives as well as several synthetic intermediate compounds were tested for acute toxicity and antidepressant activity in mice. Some of these compounds were effective in the tetrabenazine and Porsolt tests.
authors.affiliation: Instituto de Química Médica, CSIC, Madrid.
authors.forename: S
authors.initials: S
authors.lastname: Vega
authors.forename: J A
authors.initials: JA
authors.lastname: Diaz
authors.forename: V
authors.initials: V
authors.lastname: Darias
authors.forename: C C
authors.initials: CC
authors.lastname: Sanchez Mateo
authors.forename: L M
authors.initials: LM
authors.lastname: Albertos
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013329:Structure-Activity Relationship; D013550:Swimming; D013747:Tetrabenazine / Q000494:pharmacology; D013841:Thiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000928:Antidepressive Agents; D006993:Hypnotics and Sedatives; D013841:Thiazepines; D010424:Pentobarbital; D013747:Tetrabenazine