title: The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene.
abstract: Loss of heterozygosity (LOH) at the mannose 6-phosphate/insulin-like growth factor 2 receptor gene locus (M6P/IGF2R) on 6q26-27 has recently been demonstrated in approximately 30% of both invasive and in situ breast cancers. LOH was coupled with somatic point mutations in the remaining allele in several instances, leading to the proposition that M6P/IGF2R is a tumor suppressor gene. Somatic mutations in M6P/IGF2R have also been described in hepatoma and gastrointestinal cancers with the replication error positive (RER+) phenotype. These data indicate that M6P/IGF2R loss of function mutations may be involved in the pathogenesis of a wide spectrum of malignancies. Extensive data on the normal function of the M6P/IGF2R suggest that loss of M6P/IGF2R activity may contribute to multiple aspects of tumor pathophysiology, including deregulated growth, apoptosis, angiogenesis and invasion.
authors.affiliation: Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Oates
authors.forename: L M
authors.initials: LM
authors.lastname: Schumaker
authors.forename: S B
authors.initials: SB
authors.lastname: Jenkins
authors.forename: A A
authors.initials: AA
authors.lastname: Pearce
authors.forename: S A
authors.initials: SA
authors.lastname: DaCosta
authors.forename: B
authors.initials: B
authors.lastname: Arun
authors.forename: M J
authors.initials: MJ
authors.lastname: Ellis
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000648:ultrastructure*; D016147:Genes, Tumor Suppressor; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000648:ultrastructure; D008360:Mannosephosphates / Q000235:genetics* / Q000378:metabolism; D017527:Receptor, IGF Type 2 / Q000235:genetics* / Q000378:metabolism
chemical_list: D008360:Mannosephosphates; D017527:Receptor, IGF Type 2; C027693:mannose-6-phosphate