Effects of preparations of Chinese medicinal prescriptions on digestive enzymes in vitro and in vivo.
The effects of preparations of Chinese medicinal prescriptions on the activities of digestive enzymes were investigated. The starch dextrinizing activity of pancreatin was inhibited by Keishi-bukuryo-gan, Sho-seiryu-to, Hachimi-jio-gan, Unsei-in and Keishi-ka-shakuyaku-to to below 40% of the control activity. Hachimi-jio-gan and Sho-seiryu-to, in particular, lowered the activity to 4% and 24% of the control activity, respectively. The protein digestive activity of pancreatin was lowered by Keishi-bukuryo-gan, Oren-gedoku-to, Ryutan-shakan-to, Tokaku-joki-to, Yokuinin-to and Hange-shashin-to, to 56 to 70% of the control activity. To investigate the effects of the preparations of Chinese medicinal prescriptions on digestive enzymes in vivo, 600 mg (185 kBq) of 125I-egg white albumin were administered orally to rats 30 min before the administration of 100 mg of Tokaku-joki-to or Oren-gedoku-to. The radioactivity which transferred to the blood was less in the animals pre-fed these prescriptions than in the control animals, indicating that the digestion of egg white albumin was delayed in the presence of the prescriptions.
Yamasaki
K
K
Osaka Prefectural Institute of Public Health, Japan.
Kajimura
K
K
Nakano
M
M
Yokoyama
H
H
Yoneda
K
K
Umezawa
C
C
D000418:Albumins / Q000378:metabolism; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D004064:Digestive System / Q000187:drug effects* / Q000201:enzymology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D007457:Iodine Radioisotopes; D007700:Kinetics; D008297:Male; D010194:Pancreatin / Q000378:metabolism*; D010434:Pepsin A / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000418:Albumins; D004365:Drugs, Chinese Herbal; D007457:Iodine Radioisotopes; D010194:Pancreatin; D000681:Amylases; D010434:Pepsin A