[Unmasking pheochromocytoma by amitriptyline].
A report is given about a 57-year-old woman with a major depression, melancholic subtype. While under amitriptyline 75 mg/day no adverse effects were observed, immediately after increasing the dosage to 150 mg/day "head spasms" with headache, profuse sweating and arterial hypertension appeared. The diagnosis of a pheochromcytoma was made and adrenalectomy was performed. This is the first case of unmasking a pheochromcytoma by amitriptyline; furthermore a connexion was found with the daily dosage of the antidepressant.
Kuhs
H
H
Psychiatrische Universitätsklinik, Münster.
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000523:psychology; D000639:Amitriptyline / Q000008:administration & dosage* / Q000009:adverse effects; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000652:urine; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010348:Patient Care Team; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000523:psychology
D000928:Antidepressive Agents; D002395:Catecholamines; D000639:Amitriptyline
Demaskierung eines Phäochromozytoms durch Amitriptylin.