Isolated lung perfusion with antineoplastic agents for pulmonary metastases.
Lung metastases is a major cause of death in cancer patients. A technique of isolated lung perfusion that uses infusions of high doses of local chemotherapy was developed in an attempt to control local disease. This technique prevents systemic side effects. Animal experiments have been encouraging and human trials are pending.
Weksler
B
B
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Burt
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use; D002423:Cause of Death; D010478:Chemotherapy, Cancer, Regional Perfusion; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D005467:Floxuridine / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006979:Hyperthermia, Induced; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D011651:Pulmonary Artery; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D014409:Tumor Necrosis Factor-alpha; D005467:Floxuridine; D004317:Doxorubicin; D016190:Carboplatin; D002945:Cisplatin