title: Effects of aluminum hydroxide and famotidine on bioavailability of tosufloxacin in healthy volunteers.
abstract: This study was designed to determine the influence of aluminum hydroxide and famotidine on the bioavailability of tosufloxacin. Coadministration of aluminum hydroxide reduced the bioavailability of tosufloxacin by 31.6% (P < 0.05). Famotidine did not alter tosufloxacin absorption. To avoid potential treatment failures, the concurrent use of tosufloxacin and aluminum hydroxide should be avoided altogether.
authors.affiliation: Department of Pharmaceutical Services, Kumamoto University Hospital, Honjo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Minami
authors.forename: C
authors.initials: C
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Inotsume
authors.forename: M
authors.initials: M
authors.lastname: Nakano
mesh_terms: D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001682:Biological Availability; D004347:Drug Interactions; D015738:Famotidine / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D009287:Naphthyridines / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000863:Antacids; D000890:Anti-Infective Agents; D000897:Anti-Ulcer Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D000536:Aluminum Hydroxide; D015738:Famotidine; C055185:tosufloxacin