title: Comparison of intrauterine insemination with timed intercourse in superovulated cycles with gonadotropins: a meta-analysis.
abstract: OBJECTIVE
  To compare timed intercourse and IUI with the husband's sperm in patients with unexplained infertility who are undergoing superovulation with gonadotropins.
  
  
  METHODS
  Meta-analysis. All published reports of randomized, prospective studies with an English-language abstract extracted from MEDLINE were analyzed. A crossover search was done from the papers obtained.
  
  
  METHODS
  Academic center.
  
  
  METHODS
  Couples with unexplained infertility.
  
  
  METHODS
  Meta-analysis of studies evaluating patients superovulated with gonadotropins and randomized for timed intercourse or IUI.
  
  
  METHODS
  Pregnancy rates (PRs) were obtained. The common odds ratio (OR) and 95% confidence intervals (95% CI) were calculated.
  
  
  RESULTS
  There were 49 pregnancies in 431 cycles of timed intercourse (11.37%), whereas there were 110 pregnancies in 549 cycles of IUI (20.04%). The PRs for IUI were significantly increased compared with those for timed intercourse in superovulation cycles (common OR = 1.84; 95% CI = 1.30-2.62).
  
  
  CONCLUSIONS
  On the basis of the meta-analysis of 980 cycles in randomized and prospective studies, a patient's chances of becoming pregnant are greater with IUI with her husband's sperm than with timed intercourse in cycles superovulated with gonadotropins.
authors.affiliation: Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
authors.forename: H B
authors.initials: HB
authors.lastname: Zeyneloglu
authors.forename: A
authors.initials: A
authors.lastname: Arici
authors.forename: D L
authors.initials: DL
authors.lastname: Olive
authors.forename: A J
authors.initials: AJ
authors.lastname: Duleba
mesh_terms: D000328:Adult; D003075:Coitus; D005260:Female; D006062:Gonadotropins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007317:Insemination, Artificial, Homologous; D016239:MEDLINE; D008297:Male; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D013480:Superovulation; D013997:Time Factors
chemical_list: D006062:Gonadotropins