In vitro susceptibility of Chlamydia pecorum to macrolides, tetracyclines, quinolones and beta-lactam.
The in vitro susceptibility of Chlamydia pecorum to two macrolides (clarithromycin and erythromycin), two tetracyclines (doxycycline and minocycline), two quinolones (ofloxacin and ciprofloxacin) and one beta-lactam (ampicillin) was determined. The MICs were 0.004 to 0.008 microg/ml for clarithromycin, 0.008 to 0.031 microg/ml for doxycycline and minocycline, 0.063 to 0.125 microg/ml for erythromycin, 0.25 to 0.5 microg/ml for ofloxacin and 0.25 to 1.0 microg/ml for ciprofloxacin. The MIC for ampicillin was greater than 1,024 microg/ml. The results show clarithromycin and doxycycline are the two most effective drugs against C. pecorum.
Pudjiatmoko
Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Yanagido, Japan.
Fukushi
H
H
Ochiai
Y
Y
Yamaguchi
T
T
Hirai
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002417:Cattle; D002689:Chlamydia / Q000187:drug effects*; D024841:Fluoroquinolones; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D012756:Sheep; D013754:Tetracyclines; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D018942:Macrolides; D013754:Tetracyclines; D047090:beta-Lactams