title: Compilation of distinct HLA-A, -B and -C transmembrane and cytoplasmic domain-encoding sequences.
abstract: Exons 5-8 of HLA class I genes encode the transmembrane and cytoplasmic domains of HLA class I proteins. Of the more than 300 HLA-A, -B and -C alleles recognized by the WHO Nomenclature Committee for Factors of the HLA System, the number of alleles for which exon 5-8 sequence information is available and the extent of genetic variability in this region are undocumented. Thus, a comprehensive analysis of HLA-A, -B and -C exon 5-8 sequence variability was undertaken. Of 219 HLA-A, -B and -C alleles for which exon 5-8 sequences are known, 40 unique HLA-A, -B and -C exon 5-8 sequences were identified. At the amino acid level, these encode 28 distinct HLA-A, -B and -C transmembrane and cytoplasmic domains.
authors.affiliation: Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Crew
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D002462:Cell Membrane; D003593:Cytoplasm; D005091:Exons / Q000235:genetics; D005805:Genes, MHC Class I / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D015395:Histocompatibility Antigens Class I