title: Endoscopic sclerotherapy for bleeding oesophagogastric varices secondary to extrahepatic portal vein obstruction in an adult Caucasian population.
abstract: BACKGROUND
  The efficacy of endoscopic sclerotherapy for bleeding oesophagogastric varices secondary to extrahepatic portal vein obstruction in adult Caucasian patients is poorly documented.
  
  
  OBJECTIVE
  To assess the results of endoscopic sclerotherapy for all patients with this condition who have been treated and followed in our hospital since 1982.
  
  
  METHODS
  Prospective cohort study.
  
  
  RESULTS
  Twenty-one consecutive patients were included and followed during a mean period of 79 months (range 6-162 months). Active bleeding, encountered in five patients, was controlled by sclerotherapy in all cases. Two patients received a porto-systemic shunt after initial sclerotherapy. In all but one of the remaining 19 cases sclerotherapy resulted in eradication of the varices. The mean bleeding risk after initiation of sclerotherapy was 0.02 bleed/month/patient, which was lower than the estimated 0.13 bleed/month/patient prior to sclerotherapy. The actuarial rate of rebleeding at 5 years due to all causes and due to oesophagogastric varices was 35 and 28%, respectively. Two patients died, both from a haematological (pre-) malignancy. Actuarial 5 year survival was 95%.
  
  
  CONCLUSIONS
  The results of this study are in agreement with findings for paediatric and Asian patient populations and support sclerotherapy as the primary treatment modality for oesophagogastric variceal bleeding in adult Western patients with portal vein thrombosis. Life expectancy for patients with this condition is determined by the underlying cause of the portal venous obstruction.
authors.affiliation: Department of Hepatogastroenterology, University Hospital Rotterdam, The Netherlands.
authors.forename: F P
authors.initials: FP
authors.lastname: Vleggaar
authors.forename: H R
authors.initials: HR
authors.lastname: van Buuren
authors.forename: S W
authors.initials: SW
authors.lastname: Schalm
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004932:Esophageal and Gastric Varices / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D012008:Recurrence; D012189:Retrospective Studies; D015911:Sclerotherapy; D013927:Thrombosis / Q000150:complications*; D016896:Treatment Outcome; D044465:White People