Hypersensitivity to the diphtheria component in the Di-Te-Pol vaccine. A type I allergic reaction demonstrated by basophil histamine release.
We describe a two year-old multiallergic boy who developed generalized urticaria after the third Di-Te-Pol vaccination. A Type I reaction to the vaccine was demonstrated by performing basophil histamine release to the complete vaccine. Further, we found that the reaction could be exclusively ascribed to Diphtheria-Toxoid whereas no release was observed by the Polio and Tetanus component. The latter result was confirmed since no specific IgE to Tetanus Toxoid could be demonstrated.
Skov
P S
PS
Reference Laboratory, National University Hospital of Copenhagen, Denmark.
Pelck
I
I
Ebbesen
F
F
Poulsen
L K
LK
D001491:Basophils / Q000276:immunology / Q000378:metabolism; D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000009:adverse effects / Q000276:immunology; D006632:Histamine / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male
D004168:Diphtheria Toxoid; D007073:Immunoglobulin E; D006632:Histamine