title: The molecular markers of hemostatic activation on coronary artery disease.
abstract: Endothelial cells, circulating platelets, and proteins of the coagulation and fibrinolytic systems are known to contribute to the hemostatic processes. Various molecular markers of hemostatic alteration are found in increased amounts in the circulation during the activation of this process. In this study, we investigated serum lipoprotein (a) and plasma platelet factor 4, beta-thromboglobulin, thrombin-anthithrombin complex, fibrinopeptid A, D-dimer, tissue plasminogen activator, tissue plasminogen activator inhibitor, and fibronectin levels in patients with coronary artery disease. The levels of all these markers were found to be significantly higher as compared to the control group. Our findings suggest that patients with coronary artery disease have greater blood coagulability than controls, and the use of molecular markers has become greatly important in clinical practice.
authors.affiliation: Genetic and Teratology Research Center, Istanbul University, Cerrahpaşa Medical Faculty, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Ulutin
authors.forename: H
authors.initials: H
authors.lastname: Sönmez
authors.forename: N
authors.initials: N
authors.lastname: Uçişik
authors.forename: S
authors.initials: S
authors.lastname: Süer
authors.forename: C
authors.initials: C
authors.lastname: Bayram
authors.forename: E
authors.initials: E
authors.lastname: Kökoglu
authors.forename: G
authors.initials: G
authors.lastname: Sultuybek
mesh_terms: D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D015415:Biomarkers; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005344:Fibrinopeptide A / Q000032:analysis; D005353:Fibronectins / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000032:analysis; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D010978:Platelet Factor 4 / Q000032:analysis; D010959:Tissue Plasminogen Activator / Q000032:analysis; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D005353:Fibronectins; D017270:Lipoprotein(a); D017395:Plasminogen Activator Inhibitor 1; C046193:antithrombin III-protease complex; D001620:beta-Thromboglobulin; C036309:fibrin fragment D; D005344:Fibrinopeptide A; D010978:Platelet Factor 4; D000990:Antithrombin III; D010447:Peptide Hydrolases; D010959:Tissue Plasminogen Activator