title: Polydactyly and psychosis. Five cases of co-occurrence.
abstract: BACKGROUND
  Abnormalities presumed to occur during foetal life have been associated with schizophrenia. Polydactyly is a developmental abnormality but no previous association has been reported between polydactyly and functional psychotic illness.
  
  
  METHODS
  Individuals with both polydactyly and a functional psychosis were ascertained during a study of familial schizophrenia.
  
  
  RESULTS
  Five such individuals were ascertained in the course of assessing 234 individuals with familial psychosis, giving a rate of polydactyly in the sample of around 10 times the general population rate.
  
  
  CONCLUSIONS
  This study provides preliminary evidence that polydactyly is over-represented in individuals with familial schizophrenia and related psychotic illnesses.
authors.affiliation: University of Wales College of Medicine, Cardiff.
authors.forename: A G
authors.initials: AG
authors.lastname: Cardno
authors.forename: K C
authors.initials: KC
authors.lastname: Murphy
authors.forename: L A
authors.initials: LA
authors.lastname: Jones
authors.forename: A M
authors.initials: AM
authors.lastname: Cobb
authors.forename: J
authors.initials: J
authors.lastname: Gray
authors.forename: P
authors.initials: P
authors.lastname: McGuffin
authors.forename: M J
authors.initials: MJ
authors.lastname: Owen
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D017689:Polydactyly / Q000150:complications* / Q000235:genetics; D011618:Psychotic Disorders / Q000150:complications* / Q000235:genetics