title: Visual discrimination in pigeons impaired by glutamatergic blockade of nucleus accumbens.
abstract: The nucleus accumbens septi (Acc) is thought to be involved in the control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of pigeons.
authors.affiliation: Laboratorio de Neurociencias y Psicología Experimental, Universidad Católica de Mendoza, Argentina. gargiulo@fmed2.uncu.edu.ar
authors.forename: P A
authors.initials: PA
authors.lastname: Gargiulo
authors.forename: M
authors.initials: M
authors.lastname: Siemann
authors.forename: J D
authors.initials: JD
authors.lastname: Delius
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology; D010856:Columbidae; D004192:Discrimination, Psychological / Q000187:drug effects / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D005795:Generalization, Stimulus / Q000187:drug effects; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology; D008845:Microinjections; D009431:Neural Conduction / Q000187:drug effects; D009714:Nucleus Accumbens / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*
chemical_list: D000779:Anesthetics, Local; D018491:Dopamine Agonists; D018691:Excitatory Amino Acid Antagonists; D015763:2-Amino-5-phosphonovalerate; D008012:Lidocaine; D001058:Apomorphine; C031231:2-amino-7-phosphonoheptanoic acid