Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.
The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the epsilon4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE . Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.
Brindle
N
N
Centre for Research in Neurodegenerative Diseases, Department of Medicine (Division of Neurology), University of Toronto, Toronto, Ontario, Canada.
Song
Y
Y
Rogaeva
E
E
Premkumar
S
S
Levesque
G
G
Yu
G
G
Ikeda
M
M
Nishimura
M
M
Paterson
A
A
Sorbi
S
S
Duara
R
R
Farrer
L
L
St George-Hyslop
P
P
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D002091:Butyrylcholinesterase / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D005819:Genetic Markers; D002091:Butyrylcholinesterase