title: Left ventricular diastolic function of remodeled myocardium in dogs with pacing-induced heart failure.
abstract: In patients with heart failure, decreased contractility resulting in high end-diastolic pressures and a restrictive pattern of left ventricular filling produces a decrease in early diastolic filling, suggesting a stiff ventricle. This study investigated the elastic properties of the myocardium and left ventricular chamber and the ability of the heart to utilize elastic recoil to facilitate filling during pacing-induced heart failure in the anesthetized dog. Elastic properties of the myocardium were determined by analyzing the myocardial stress-strain relation. Left ventricular chamber properties were determined by analyzing the pressure-volume relation using a logarithmic approach. Elastic recoil was characterized using a computer-controlled mitral valve occluder to prevent transmittral flow during diastole. We conclude that, during heart failure, the high end-diastolic pressures suggestive of a stiff ventricle are due not to stiffer myocardium but to a ventricle whose chamber compliance characteristics are changed due to geometric remodeling of the myocardium. The restrictive filling pattern is a result of the ventricle being forced to operate on the stiff portion of the diastolic pressure-volume relation to maintain cardiac output. Slowed relaxation and decreased contractility result in an inability of the heart to contract to an end-systolic volume below its diastolic equilibrium volume. Thus the left ventricle cannot utilize elastic recoil to facilitate filling during heart failure.
authors.affiliation: Department of Cardiothoracic Surgery, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Solomon
authors.forename: S D
authors.initials: SD
authors.lastname: Nikolic
authors.forename: S A
authors.initials: SA
authors.lastname: Glantz
authors.forename: E L
authors.initials: EL
authors.lastname: Yellin
mesh_terms: D000818:Animals; D003971:Diastole; D004285:Dogs; D004452:Echocardiography; D004548:Elasticity; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology*; D006339:Heart Rate; D006349:Heart Valve Diseases / Q000503:physiopathology; D006439:Hemodynamics; D008943:Mitral Valve; D009200:Myocardial Contraction