[Kinetics of development of human melanoma xenografts in immunosuppressed animals].
An experimental model of development of the human tumor xenografts (melanomas HCMB and Bro) in immunosuppressed phenotypically normal animals (CBA/Ca mice) was developed. Optimal conditions were established for immunodeficiency induction in the animals. Kinetics of development of the xenografts in the immunosuppressed animals was studied. The level of 0(6)-alkyl-guanine-DNA-alkyltransferase, an enzyme responsible for repair of DNA damage in the tumor cells induced by chemotherapeutic agents (nitroalkylurea), was determined.
Ostrovskaia
L A
LA
Emanuel' Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Ul'ianova
N M
NM
Fomina
M M
MM
Rykova
V A
VA
Konradov
A A
AA
Brin
E F
EF
Gorbunova
N V
NV
Gorbacheva
L B
LB
Khaleev
D V
DV
D000818:Animals; D002279:Carcinoma 256, Walker / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D018827:Carcinoma, Lewis Lung / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007700:Kinetics; D008546:Melanoma, Experimental / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000378:metabolism; D014183:Transplantation, Heterologous / Q000276:immunology / Q000473:pathology*
D019853:O(6)-Methylguanine-DNA Methyltransferase
Kinetika razvitiia ksenograftov melanom cheloveka na immunosupressirovannykh zhivotnykh.