Long-term follow up of patients with toenail onychomycosis after treatment with terbinafine.
The long-term outcome of 111 patients treated with oral terbinafine for toenail onychomycosis with a novel treatment protocol was assessed a median of 138 weeks after entry into the trial. All but three patients had either one or two 12 week courses of terbinafine 250 mg daily. Of the 77 evaluable patients, 72.7% were still classified as responders (i.e. negative mycological culture and at least 3 mm of new unaffected nail growth) on reassessment. The present study shows that a favourable long-term outcome can be achieved in patients who have been treated with at least one 12 week course of terbinafine.
Watson
A B
AB
Royal Newcastle Hospital, New South Wales, Australia.
Marley
J E
JE
Ellis
D H
DH
Williams
T G
TG
D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use*; D014009:Onychomycosis / Q000188:drug therapy*; D000077291:Terbinafine; D016896:Treatment Outcome
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine