Lipoblastoma: a case with t(7;8)(q31;q13).
Lipoblastoma is a rare benign adipose tumor which, in all of the cases so far described, presents an involvement of chromosome 8 in the region 8q11-13. We hereby report the results of the second case of lipoblastoma studied by fluorescence in situ hybridization (FISH), in a 13-month-old boy. An abnormal karyotype 46,XY,t(7;8)(q31;q13) was found in 90% of the metaphases examined, in agreement with the previously reported observations. We suggest the region 8q11-13 may contain a relevant locus for lipoblastoma origin.
Panarello
C
C
Department of Pediatric Hematology/Oncology, Giannina Gaslini Institute, Genova, Italy.
Rosanda
C
C
Morerio
C
C
Russo
I
I
Dallorso
S
S
Gambini
C
C
Ricco
A S
AS
Storlazzi
T
T
Archidiacono
N
N
Rocchi
M
M
D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008067:Lipoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic