Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens.
The prefrontal cortex and nucleus accumbens are primary recipients of medial thalamic inputs, prominently including projections from the thalamic paraventricular nucleus. It is not known if paraventricular neurons collateralize to innervate both the prefrontal cortex and nucleus accumbens. We used dual retrograde tract tracing methods to examine this question. A small population of paraventricular neurons was found to innervate the prefrontal cortex and medial nucleus accumbens. These data suggest that the thalamic paraventricular nucleus may coordinately influence activity in the prefrontal cortex and ventral striatum.
Bubser
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M
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA. michael.bubser@mcmail.vanderbilt.edu
Deutch
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D000578:Amidines; D000818:Animals; D005456:Fluorescent Dyes; D007150:Immunohistochemistry; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology*; D009714:Nucleus Accumbens / Q000166:cytology / Q000502:physiology*; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013266:Stilbamidines; D013787:Thalamic Nuclei / Q000166:cytology / Q000502:physiology*
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D000578:Amidines; D005456:Fluorescent Dyes; D013266:Stilbamidines; C031455:diamidino compound 253-50