title: The EPA health risk assessment of methylcyclopentadienyl manganese tricarbonyl (MMT).
abstract: This paper describes the U.S. Environmental Protection Agency's assessment of potential health risks associated with the possible widespread use of a manganese (Mn)-based fuel additive, methylcyclopentadienyl manganese tricarbonyl (MMT). This assessment was significant in several respects and may be instructive in identifying certain methodological issues of general relevance to risk assessment. A major feature of the inhalation health risk assessment was the derivation of Mn inhalation reference concentration (RfC) estimates using various statistical approaches, including benchmark dose and Bayesian analyses. The exposure assessment component used data from the Particle Total Exposure Assessment Methodology (PTEAM) study and other sources to estimate personal exposure levels of particulate Mn attributable to the permitted use of MMT in leaded gasoline in Riverside, CA, at the time of the PTEAM study; on this basis it was then possible to predict a distribution of possible future exposure levels associated with the use of MMT in all unleaded gasoline. Qualitative as well as quantitative aspects of the risk characterization are summarized, along with inherent uncertainties due to data limitations.
authors.affiliation: National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Davis
authors.forename: A M
authors.initials: AM
authors.lastname: Jarabek
authors.forename: D T
authors.initials: DT
authors.lastname: Mage
authors.forename: J A
authors.initials: JA
authors.lastname: Graham
mesh_terms: D000280:Administration, Inhalation; D001499:Bayes Theorem; D004781:Environmental Exposure; D005742:Gasoline / Q000633:toxicity; D006801:Humans; D008345:Manganese / Q000008:administration & dosage; D020149:Manganese Poisoning; D009420:Nervous System / Q000187:drug effects; D019055:No-Observed-Adverse-Effect Level; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000633:toxicity*; D018570:Risk Assessment; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D005742:Gasoline; D009942:Organometallic Compounds; C009907:2-methylcyclopentadienyl manganese tricarbonyl; D008345:Manganese