title: [A case of refractory bronchial asthma improving with treatments of sleep apnea syndrome].
abstract: A 29-year-old woman of the bronchial asthma was admitted to our hospital. Her asthmatic symptoms were refractory in spite of the administration of 30 mg of daily-oral prednisolone. During the asthma-attack, marked arterial oxygen desaturation was noted. So we doubted that she had obstructive sleep apnea complicated with obesity. Sleep Apnea Monitor revealed her nocturnal desaturation and frequent sleep apnea. To avoid the desaturation, we recommended her to keep prone position during the sleep. And both desaturation and asthmatic symptoms were dramatically improved. Nasal-CPAP also had been effective for them. These findings suggest that sleep apnea mediated oxygen desaturation may be one of the promotor of asthmatic symptoms.
authors.affiliation: Fourth Department of Internal Medicine, Tokyo Jikeikai Medical School.
authors.forename: Y
authors.initials: Y
authors.lastname: To
authors.forename: T
authors.initials: T
authors.lastname: Koshino
authors.forename: M
authors.initials: M
authors.lastname: Kubo
authors.forename: H
authors.initials: H
authors.lastname: Muramatsu
authors.forename: K
authors.initials: K
authors.lastname: Kudo
authors.forename: J
authors.initials: J
authors.lastname: Kabe
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001249:Asthma / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002908:Chronic Disease; D005260:Female; D006801:Humans; D010366:Peak Expiratory Flow Rate; D011175:Positive-Pressure Respiration; D011239:Prednisolone / Q000008:administration & dosage; D016684:Prone Position / Q000502:physiology; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000628:therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D011239:Prednisolone