Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: a potential novel treatment in a rat model of Huntington's disease.
Bilateral electrolytic pallidal lesion ameliorated the deleterious effects of bilateral quinolinic acid (QA) lesion to the striatum on post-surgery weight, activity level, and performance in a water maze task, and reduced the extent of striatal damage. Given that the neurodegenerative and behavioral effects of QA striatal lesion are thought to mimic those seen in Huntington's disease, these results may point to a potential novel treatment for this disease.
Joel
D
D
Department of Psychology, Tel-Aviv University, Ramat-Aviv, Tel-Aviv 69978, Israel.
Ayalon
L
L
Tarrasch
R
R
Veenman
L
L
Feldon
J
J
Weiner
I
I
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D004572:Electrolysis; D005917:Globus Pallidus / Q000502:physiology*; D006816:Huntington Disease / Q000473:pathology / Q000628:therapy*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology*; D009410:Nerve Degeneration / Q000503:physiopathology*; D017378:Quinolinic Acid / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D017378:Quinolinic Acid