In vitro studies of simulated percutaneous absorption: influence of various enhancers in the release of clonazepam from 2-hydroxyethyl acetate patches.
A diffusion cell with an artificial membrane and the single-pass perfused rabbit ear were used to evaluate the percutaneous absorption of clonazepam from various 2-hydroxyethyl acetate (HEA) patches. The influence on drug permeation of the various type of enhancers (isopropylmyristate, lauryl alcohol, propylene glycol and water) in the patches was tested. A comparison between the two types of systems of percutaneous absorption of clonazepam has been done. The results showed that HEA patches produce controlled uniform drug release, modulated by the addition of enhancers.
Corti
P
P
Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Italy. corti@unisi.it
Dreassi
E
E
Mura
P
P
Perruccio
P L
PL
D000279:Administration, Cutaneous; D000818:Animals; D002998:Clonazepam / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005026:Ethylene Glycols / Q000737:chemistry*; D066298:In Vitro Techniques; D011817:Rabbits; D012869:Skin Absorption
D005026:Ethylene Glycols; C028001:glycol monoacetate; D002998:Clonazepam