Protective immune responses to Theileria annulata of relevance to vaccine development.
A series of projects on Theileria annulata funded by the European Union (STD1/STD2/STD3) have provided convincing evidence that macrophage and natural killer (NK) cell-dependent immune mechanisms may directly control the proliferation of different stages of T. annulata in cattle. The evidence for this conclusion and the implications for vaccine development are discussed in the following paper.
Preston
P M
PM
Division of Biological Sciences, University of Edinburgh, Scotland, U.K.
Visser
A
A
Abraham
A
A
Richardson
W
W
Richardson
J
J
Forsyth
L
L
Bell-Sakyi
L
L
Wilkie
G
G
Entrican
G
G
Boid
R
R
Spooner
R L
RL
Brown
C G
CG
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D016052:Protozoan Vaccines; D016796:Theileria annulata / Q000254:growth & development / Q000276:immunology*; D013801:Theileriasis / Q000276:immunology*
D000953:Antigens, Protozoan; D016052:Protozoan Vaccines