title: The effect of lead exposure on behavior problems in preschool children.
abstract: OBJECTIVE
  Interpreting associations between lead exposure and child behavior problems is difficult because studies have not controlled for sociodemographic confounders or have used shed teeth to mark exposure. This study explored associations between blood lead and preschool behavior.
  
  
  METHODS
  Children from a smelter town and a non-lead-exposed town in Yugoslavia were followed up prospectively from pregnancy through age 3. The Child Behavior Checklist was used to assess behavior problems in 379 3-year-olds, controlling for sociodemographic factors and difficult infant temperament.
  
  
  RESULTS
  Multiple regression revealed the expected significant associations between checklist subscales and sociodemographic factors, which explained 7% to 18% of the variance on the subscales. Concurrent blood lead explained a significant 1% to 4% of the variance on the Destructive and Withdrawn subscales. Earlier difficult temperament explained an additional 2% to 5% of the checklist variance. Scores on the Destructive subscale were consistently associated with blood lead. As blood lead increased from 10 to 20 micrograms/dL, subscale scores increased by approximately 0.5 points.
  
  
  CONCLUSIONS
  Lead/behavior associations are significant but small compared with the effects of social factors.
authors.affiliation: Department of Child Psychiatry, Columbia University, New York State Psychiatric Institute, NY 10032, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Wasserman
authors.forename: B
authors.initials: B
authors.lastname: Staghezza-Jaramillo
authors.forename: P
authors.initials: P
authors.lastname: Shrout
authors.forename: D
authors.initials: D
authors.lastname: Popovac
authors.forename: J
authors.initials: J
authors.lastname: Graziano
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects; D002653:Child Behavior Disorders / Q000097:blood / Q000209:etiology*; D002675:Child, Preschool; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D012044:Regression Analysis; D012959:Socioeconomic Factors; D013694:Temperament; D015022:Yugoslavia
chemical_list: D000395:Air Pollutants, Occupational; D007854:Lead