title: Food restriction alters pregnancy-associated changes in IGF and IGFBP in the guinea pig.
abstract: The effect of moderate food restriction on pregnancy-associated changes in weight gain, body composition, and circulating insulin-like growth factors (IGF) I and II and IGF-binding proteins (IGFBP)-1 through-4 and their relationship was determined in the guinea pig. Pregnancy did not stimulate weight gain but reduced fat deposition in ad libitum-fed animals and increased weight gain and fat deposition in food-restricted animals relative to their respective virginal group. Pregnancy increased the abundance of circulating IGF-I regardless of food intake and increased that of IGF-II in food-restricted animals only. Pregnancy also increased circulating IGFBP-1 and -2 in ad libitum-fed and food-restricted animals and IGFBP-4 in ad libitum-fed animals. Multiple regression analysis showed that maternal weight gain was negatively associated with circulating IGF-II and IGFBP-2. Fetal weight was positively associated with maternal circulating IGF-II and negatively associated with maternal circulating IGFBP-1 and -2. Significant interactions indicate, however, that the role of IGF-II and IGFBP-1 on fetal growth is dependent on the nutritional status of the mother.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Adelaide, South Australia.
authors.forename: A
authors.initials: A
authors.lastname: Sohlström
authors.forename: A
authors.initials: A
authors.lastname: Katsman
authors.forename: K L
authors.initials: KL
authors.lastname: Kind
authors.forename: C T
authors.initials: CT
authors.lastname: Roberts
authors.forename: P C
authors.initials: PC
authors.lastname: Owens
authors.forename: J S
authors.initials: JS
authors.lastname: Robinson
authors.forename: J A
authors.initials: JA
authors.lastname: Owens
mesh_terms: D000818:Animals; D001823:Body Composition; D005314:Embryonic and Fetal Development; D005260:Female; D005508:Food Deprivation; D006168:Guinea Pigs; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D018974:Insulin-Like Growth Factor Binding Protein 4 / Q000097:blood; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D010929:Placentation; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D015430:Weight Gain
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D018974:Insulin-Like Growth Factor Binding Protein 4; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II