title: Characterization of FOX-3, an AmpC-type plasmid-mediated beta-lactamase from an Italian isolate of Klebsiella oxytoca.
abstract: Klebsiella oxytoca 1731, which showed a wide spectrum of resistance to beta-lactams, including cefoxitin, was isolated in 1994 from a patient in Genoa, Italy. This strain contained a plasmid-mediated AmpC beta-lactamase with a pI of 7.25. Sequencing of the corresponding DNA of K. oxytoca 1731 revealed 96 and 97% identities of the deduced amino acid sequence with FOX-1 and FOX-2, respectively.
authors.affiliation: Istituto Di Microbiologia, Genoa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Marchese
authors.forename: G
authors.initials: G
authors.lastname: Arlet
authors.forename: G C
authors.initials: GC
authors.lastname: Schito
authors.forename: P H
authors.initials: PH
authors.lastname: Lagrange
authors.forename: A
authors.initials: A
authors.lastname: Philippon
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D005260:Female; D006801:Humans; D007558:Italy; D007709:Klebsiella / Q000201:enzymology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D001618:beta-Lactamases / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D047090:beta-Lactams; C111085:FOX-3 protein, Klebsiella oxytoca; D001618:beta-Lactamases