High-performance liquid chromatographic assay of 8-hydroxyquinoline sulfate and its stability in immunobiological preparations.
Because of the ability of 8-hydroxyquinoline sulfate (8-HQS) to irreversibly bind metals from rubber stoppers, the stability of 8-HQS in tuberculin solutions was investigated. For the determination of 8-HQS, a simple and sensitive reversed-phase HPLC method with detection at 240 nm was developed and validated. Rapid decreases in concentrations of 8-HQS were found in samples stored in original vials which were exposed to different temperatures and vial positions.
Mihajlović
A
A
Control Department, TORLAK, Belgrade, Yugoslavia.
Agbaba
D
D
Zivanov-Stakić
D
D
Ristić
P
P
Dordjević
M
M
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004340:Drug Contamination; D004355:Drug Stability; D004356:Drug Storage; D007700:Kinetics; D015125:Oxyquinoline / Q000032:analysis*; D013696:Temperature; D014373:Tuberculin / Q000032:analysis*
D014373:Tuberculin; D015125:Oxyquinoline