title: [Splenic vein thrombosis with pancytopenia and fever: antiphospholipid antibody syndrome].
abstract: Antiphospholipid antibody syndrome (APS) is now recognized as one of the most important causes of hypercoagulability. The most common site for venous thrombosis in APS is deep venous thrombosis of the lower extremities. Other sites of venous thrombosis include retinal veins, renal veins, and hepatic veins. The authors report a case of splenic vein thrombosis disclosing antiphospholipid syndrome in which also the cytolytic effect of aPL may play a role of "cofactor" in the genesis of thrombosis through the release of thromboplastin from the lysis of red cells, granulocytes and platelets, making them vulnerable to clearance by splenic macrophages. Important considerations are stressed about differential diagnosis, etiopathogenetic factors, therapy and follow-up of the patient.
authors.affiliation: V Divisione di Medicina Interna, Ospedale San Camillo, Roma.
authors.forename: V S
authors.initials: VS
authors.lastname: Adducchio
authors.forename: C
authors.initials: C
authors.lastname: Bibbolino
authors.forename: M
authors.initials: M
authors.lastname: Compagnucci
authors.forename: M G
authors.initials: MG
authors.lastname: Corpetti
authors.forename: A
authors.initials: A
authors.lastname: Cortese
authors.forename: E
authors.initials: E
authors.lastname: Maddaloni
authors.forename: V
authors.initials: V
authors.lastname: Miele
authors.forename: M
authors.initials: M
authors.lastname: Scoppio
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis; D005334:Fever / Q000209:etiology*; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000175:diagnosis / Q000209:etiology*; D013162:Splenic Vein; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
vernacular_title: Trombosi della vena splenica con pancitopenia e febbre: sindrome da anticorpi antifosfolipidi.