title: Genomic amplification of CCND2 is rare in non-Hodgkin lymphomas.
abstract: Cyclin D2, encoded by CCND2 at 12p13, takes part in the regulation of the cell cycle and has been suggested as a candidate for gene amplification in lymphoid malignancies. CCND2 is often overexpressed in chronic B-cell disorders, and we recently detected genomic amplification of the chromosomal region containing CCND2 in two of three investigated non-Hodgkin lymphomas (NHLs) with cytogenetic abnormalities involving 12p. In the present study, 58 NHLs without karyotypic evidence of 12p aberrations were analyzed by fluorescence in situ hybridization with probes for CCND2. No genomic amplification was found, strongly suggesting that this abnormality is rare in such NHLs.
authors.affiliation: Department of Clinical Genetics, Lund University Hospital, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Andreasson
authors.forename: B
authors.initials: B
authors.lastname: Johansson
authors.forename: K
authors.initials: K
authors.lastname: Arheden
authors.forename: U
authors.initials: U
authors.lastname: Kristoffersson
authors.forename: M
authors.initials: M
authors.lastname: Akerman
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
authors.forename: M
authors.initials: M
authors.lastname: Höglund
mesh_terms: D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D056742:Cyclin D2; D016213:Cyclins / Q000235:genetics*; D005784:Gene Amplification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*
chemical_list: C080336:CCND2 protein, human; D056742:Cyclin D2; D016213:Cyclins