Altered response to stimuli of the AP-1/DNA binding activity in a syndrome of precocious ageing (geroderma osteodysplastica hereditaria).
Cell senescence produces changes in the expression of specific genes, suggesting that senescent cells express an altered pattern of transcription factors. Here we describe how the DNA binding activity of the activator protein 1(AP-1) complex is altered in the fibroblasts of a geroderma osteodysplastica patient in response to extracellular stimuli.
Gherzi
R
R
Cell Biology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
Bellini
C
C
Bonioli
E
E
D000375:Aging / Q000378:metabolism*; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D013577:Syndrome; D018808:Transcription Factor AP-1 / Q000378:metabolism*
D004268:DNA-Binding Proteins; D018808:Transcription Factor AP-1