title: Vanadium toxicology--an assessment of general health, haematological aspects and energy response in an Indian catfish Clarias batrachus (Linn).
abstract: The pervasive occurrence of vanadium in nature and its use in various industrial processes has increased its inputs in the environment. This has prompted us to elucidate the impact of vanadium on aquatic environment, the primary body for industrial effluent discharge. The energy response of the fish, Clarias batrachus, its haematological status including haemoglobin (Hb), haematocrit (Ht), leutocrit (Lt), mean corpuscular haemoglobin (MCH), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC) etc. And overall general health conditions have been observed to be significantly hampered leading to deleterious alterations in the general metabolism of the fish following long term exposure to vanadate. The increase in muscle and tissue lactic acid (2-12 fold) in association with decrease in pyruvic acid (72% in muscle; 26% in liver) reflect a shift towards an anaerobic metabolism of the fish. We conclude that vanadium could be toxic for the fish in question under long term exposure at the doses under observation (2-10 mg L-1).
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: A
authors.initials: A
authors.lastname: Chakraborty
authors.forename: S
authors.initials: S
authors.lastname: Oinam
authors.forename: R
authors.initials: R
authors.lastname: Karmakar
authors.forename: M
authors.initials: M
authors.lastname: Chatterjee
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D002397:Catfishes / Q000097:blood* / Q000378:metabolism*; D004734:Energy Metabolism; D004784:Environmental Monitoring; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007194:India; D019344:Lactic Acid / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D019289:Pyruvic Acid / Q000378:metabolism; D014639:Vanadium / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D006454:Hemoglobins; D008112:Liver Glycogen; D014874:Water Pollutants, Chemical; D014639:Vanadium; D019344:Lactic Acid; D019289:Pyruvic Acid