title: Clinical results of implantation of the Chirila keratoprosthesis in rabbits.
abstract: OBJECTIVE
  An ideal keratoprosthesis (KPro) would closely resemble a donor corneal button in terms of its surgical handling, optics, and capacity to heal with host tissue in order to avoid many of the complications associated with the KPros which are currently in clinical use. This study was carried out to assess the long term clinical outcomes on implantation of the core and skirt poly(2-hydroxyethyl methacrylate) KPro in animals.
  
  
  METHODS
  20 KPros were made and implanted as full thickness corneal replacements into rabbits and followed for up to 21 months to date.
  
  
  RESULTS
  80% of the prostheses have been retained, with a low incidence of complications such as cataract, glaucoma, and retroprosthetic membrane formation which are frequently associated with KPro surgery.
  
  
  CONCLUSIONS
  KPros of this type may offer promise in the treatment of patients for whom penetrating keratoplasty with donor material carries a poor prognosis. Refinement of the KPro and further animal trials, including implantation into abnormal corneas, are however mandatory before human implantation could be planned.
authors.affiliation: Lions Eye Institute, Perth, Western Australia.
authors.forename: C R
authors.initials: CR
authors.lastname: Hicks
authors.forename: T V
authors.initials: TV
authors.lastname: Chirila
authors.forename: A B
authors.initials: AB
authors.lastname: Clayton
authors.forename: J H
authors.initials: JH
authors.lastname: Fitton
authors.forename: S
authors.initials: S
authors.lastname: Vijayasekaran
authors.forename: P D
authors.initials: PD
authors.lastname: Dalton
authors.forename: X
authors.initials: X
authors.lastname: Lou
authors.forename: S
authors.initials: S
authors.lastname: Platten
authors.forename: B
authors.initials: B
authors.lastname: Ziegelaar
authors.forename: Y
authors.initials: Y
authors.lastname: Hong
authors.forename: G J
authors.initials: GJ
authors.lastname: Crawford
authors.forename: I J
authors.initials: IJ
authors.lastname: Constable
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D003315:Cornea / Q000601:surgery*; D007431:Intraoperative Complications; D011102:Polyhydroxyethyl Methacrylate; D011475:Prosthesis Failure; D017755:Prosthesis Fitting / Q000379:methods; D011817:Rabbits; D013529:Surgical Wound Dehiscence; D016896:Treatment Outcome
chemical_list: D011102:Polyhydroxyethyl Methacrylate