Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica.
Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported.
Gunatilaka
A A
AA
Department of Chemistry, Virginia Polytechnic Institute, Blacksburg, USA.
Bolzani
V da S
Vda S
Dagne
E
E
Hofmann
G A
GA
Johnson
R K
RK
McCabe
F L
FL
Mattern
M R
MR
Kingston
D G
DG
D002240:Carbohydrate Sequence; D004260:DNA Repair / Q000235:genetics*; D005002:Ethiopia; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D009654:Norsteroids / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes / Q000633:toxicity*
D009654:Norsteroids; D010936:Plant Extracts; D014315:Triterpenes