Effects of carbamazepine on plasma extravasation and bronchoconstriction induced by substance P, capsaicin, acetaldehyde and histamine in guinea-pig lower airways.
We evaluated the in vivo effects of the pretreatment with carbamazepine (CBZ) at different doses (10, 20 and 40 mg/kg p.o.) on the Evans-blue extravasation and on bronchoconstriction induced by different substances in guinea-pig tracheal tissue. The drug dose-dependently inhibited the extravasation induced by substance P (SP), capsaicin and acetaldehyde, but not that induced by histamine. At the highest dose (40 mg/kg) CBZ inhibited the bronchoconstriction induced by SP, capsaicin and acetaldehyde, but not that produced by histamine administration. The in vitro study with guinea-pig tracheal preparation indicates that the drug does not interfere with the binding of SP to its receptors. Our results suggest that CBZ exerts a protective activity against the pro-inflammatory action of SP.
Bianchi
M
M
Department of Pharmacology, University of Milan, Italy.
Rossoni
G
G
Maggi
R
R
Panerai
A E
AE
Berti
F
F
D000079:Acetaldehyde / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism / Q000494:pharmacology*; D016084:Bronchoconstriction / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects*; D002211:Capsaicin / Q000494:pharmacology; D002220:Carbamazepine / Q000378:metabolism / Q000494:pharmacology*; D005070:Evans Blue; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D004364:Pharmaceutical Preparations; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D013373:Substance P / Q000378:metabolism* / Q000494:pharmacology; D014132:Trachea / Q000098:blood supply / Q000187:drug effects*
D000927:Anticonvulsants; D004364:Pharmaceutical Preparations; D018040:Receptors, Neurokinin-1; D013373:Substance P; D002220:Carbamazepine; D005070:Evans Blue; D006632:Histamine; D000079:Acetaldehyde; D002211:Capsaicin