Studies on hyperthermia combined with arterial blockade for treatment of tumors: (Part II) effectiveness of hyperthermia combined with arterial embolization using degradable starch microspheres.
The efficacy of temporary arterial embolization using degradable starch microspheres combined with hyperthermia was investigated in rabbits bearing VX2 tumors. Microsphere injection caused a marked decrease of tumor blood flow and pH. During heating, there was a marked increase of the maximum temperature in tumor tissue compared with normal muscle. Tumor growth was suppressed 330% times at 3 weeks after hyperthermia alone and 270% times following combined treatment with microspheres and hyperthermia. Damage to normal muscle tissue was mild. In conclusion, this combination therapy may be useful for causing selective tumor damage and reducing the effect on normal tissues.
Murata
T
T
Department of Radiology, Kansai Medical University, 10-15 Fumizonochou, Moriguchi City, Osaka, 570, Japan.
Akagi
K
K
Imamura
M
M
Nasu
R
R
Kimura
H
H
Nagata
K
K
Tanaka
Y
Y
D000818:Animals; D001673:Biodegradation, Environmental; D001783:Blood Flow Velocity; D002452:Cell Count / Q000187:drug effects; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D007083:Iliac Artery / Q000503:physiopathology; D008297:Male; D008863:Microspheres; D018482:Muscle, Skeletal / Q000098:blood supply; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology / Q000628:therapy*; D011817:Rabbits; D013213:Starch
D013213:Starch