Use of trans-Sialidase inhibition assay in a population serologically negative for Trypanosoma cruzi but at a high risk of infection.
trans-Sialidase inhibition assay (TIA) was employed in a population at high risk of Trypanosoma cruzi infection. From 20 serum samples that were negative by conventional serologic and parasitologic assays, 18 (90%) were reactive in TIA, providing further evidence of the higher sensitivity of TIA and suggesting that the actual prevalence of T. cruzi infection might be underestimated.
Leguizamón
M S
MS
Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Paraguay.
Russomando
G
G
Rojas de Arias
A
A
Samudio
M
M
Cabral
M
M
González-Cappa
S M
SM
Frasch
A C
AC
Campetella
O
O
D000818:Animals; D014355:Chagas Disease / Q000097:blood*; D006801:Humans; D009439:Neuraminidase; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods*; D014349:Trypanosoma cruzi / Q000302:isolation & purification*
D009439:Neuraminidase