Improvement of nalbuphine bioavailability through rectal administration of a prodrug.
Chang
R K
RK
DuPont Merk Pharmaceutical Company, Wilmington, Delaware 19880-0400, USA.
Hussain
M A
MA
D000285:Administration, Rectal; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D005260:Female; D006207:Half-Life; D009266:Nalbuphine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011355:Prodrugs / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000701:Analgesics, Opioid; D011355:Prodrugs; D009266:Nalbuphine