High throughput analysis and purification in support of automated parallel synthesis.
Rapid reverse-phase analytical and preparative HPLC methods have been developed for application to parallel synthesis libraries. Gradient methods, short columns, and high flow rates allow analysis of over 300 compounds per day on a single system, or purification of up to 200 compounds per day on a single preparative system. Hardware and software modifications allow continuous unattended use for maximum efficiency and throughput.
Weller
H N
HN
Combinatorial Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
Young
M G
MG
Michalczyk
S J
SJ
Reitnauer
G H
GH
Cooley
R S
RS
Rahn
P C
PC
Loyd
D J
DJ
Fiore
D
D
Fischman
S J
SJ
D001331:Automation; D001671:Biochemistry / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D012984:Software