A newly synthesized neurotropic pyrimidine compound, MS-818, may activate migratory schwann cells in peripheral nerve regeneration.
Following transection of a peripheral nerve in mice, a newly synthesized neurotropic pyrimidine compound, MS-818 was administered intraperitoneally at a dose of 1 mg kg-1 b.wt. day-1. The film model experiments for analyzing the early growth of axonal regeneration suggested that MS-818 activated Schwann cells which migrate from the proximal stump, inducing axonal elongation in vivo.
Torigoe
K
K
Department of Anatomy, Fukui Medical School, Matsuoka, Fukui 910-1193, Japan.
Awaya
A
A
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000648:ultrastructure; D019771:Axotomy; D002465:Cell Movement / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011743:Pyrimidines / Q000494:pharmacology*; D009418:S100 Proteins / Q000096:biosynthesis; D012583:Schwann Cells / Q000187:drug effects* / Q000378:metabolism
C096499:MS 818; D011743:Pyrimidines; D009418:S100 Proteins