Expression of fibroblast growth factor receptor in adult mouse utricle damaged by streptomycin sulfate.
The expression of fibroblast growth factor (FGF) receptor was investigated in adult mouse utricles damaged by streptomycin sulfate using confocal laser scanning microscopy (CLSM). The nerve endings in the mouse utricles could be detected by the immunoreactivity of neurofilament by CLSM. In the utricles of control adult mice, little expression of FGF receptor could be detected by a method of double staining for FGF receptor and neurofilament immunoreactivities. However, the expression of FGF immunoreactivity increased in the nerve endings of the damaged utricles. This result suggests that FGF is probably related to the synaptic plasticity in the adult mouse utricles.
Yamashita
H
H
Department of Otolaryngology, Yamaguchi University School of Medicine, Japan.
Gondo
T
T
Ishihara
T
T
Takahashi
M
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D051379:Mice; D009473:Neuronal Plasticity / Q000187:drug effects; D017468:Receptors, Fibroblast Growth Factor / Q000096:biosynthesis* / Q000187:drug effects*; D012444:Saccule and Utricle / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism* / Q000473:pathology; D013307:Streptomycin / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D017468:Receptors, Fibroblast Growth Factor; D013307:Streptomycin