Effect of the Yang tonifying herbs on myocardial beta-adrenoceptors of hypothyroid rabbits.
New Zealand White female rabbits were randomly divided into three groups, each contained six rabbits, i.e. thyroidectomized and untreated rabbits (group 1), thyroidectomized rabbits treated by the Yang tonifying herbs (group 2) and sham thyroidectomized rabbits as controls (group 3). The myocardial beta-adrenoceptor density (Bmax) and affinity (Kd) of each group of rabbits were determined by radioligand binding assay technique on the thirtieth postoperative day and the data were handled by using a computer program of the Woolf plot with weight regression. Moreover, the serum levels of thyroxine (T4) and triiodothyronine (T3) of each group of rabbits were measured by radioimmunoassay technique and their heart rates (HR) were also recorded on the preoperative and thirtieth postoperative day. The results showed that the Bmax, T4, T3 and HR in group 1 were lower significantly than that in group 3 (P < 0.01-0.001), but the change of Kd in group 1 was not significant; the deviation of the indices from the normal value in group 2 was less remarkably than in group 1 other than T4.
Min
X
X
Department of Medicine, University of Western Australia, Perth.
Xiaohui
Z
Z
Zhaixiang
D
D
Ming
O
O
D000319:Adrenergic beta-Antagonists / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D004082:Dihydroalprenolol / Q000378:metabolism / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate; D007037:Hypothyroidism / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D011863:Radioimmunoassay; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000378:metabolism; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014316:Tritium
D000319:Adrenergic beta-Antagonists; D004365:Drugs, Chinese Herbal; D011943:Receptors, Adrenergic, beta; D014284:Triiodothyronine; D014316:Tritium; D004082:Dihydroalprenolol; D013974:Thyroxine