title: Effect of HLA matching on outcome of related and unrelated donor transplantation therapy for chronic myelogenous leukemia.
abstract: This article examines the diversity and biologic role of human lymphocyte antigen (HLA) genes as related to marrow transplantation for chronic myelogenous leukemia (CML). A better understanding of the nature and function of HLA variation is necessary as unrelated marrow transplantation evolves into a safe and effective treatment for CML. HLA matching is an important aspect of donor selection criteria and has a role in engraftment as well as the development of graft-versus-host disease and tolerance after transplant.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: E
authors.initials: E
authors.lastname: Petersdorf
authors.forename: C
authors.initials: C
authors.lastname: Anasetti
authors.forename: P
authors.initials: P
authors.lastname: Servida
authors.forename: P
authors.initials: P
authors.lastname: Martin
authors.forename: J
authors.initials: J
authors.lastname: Hansen
mesh_terms: D016026:Bone Marrow Transplantation; D006084:Graft Rejection / Q000235:genetics; D006086:Graft vs Host Disease / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D006680:HLA Antigens