Studies on hyperthermia combined with arterial blockade for treatment of tumors: (Part I) effectiveness of hyperthermia combined with arterial ligation.
Arterial ligation was combined with hyperthermia in rabbits with VX2 tumors implanted in the leg. For seven days after arterial ligation, blood flow was decreased and the pH was low in both normal muscle and tumor tissue. The temperature of normal muscle and tumor tissue increased faster and reached a higher level on heating immediately after ligation than without ligation. The antitumor effect of hyperthermia was stronger immediately after ligation than two or seven days afterwards. However, damage to normal muscle was severe with this combination therapy, so a better method of therapeutic arterial blockade is needed.
Murata
T
T
Department of Radiology, Kansai Medical University, 10-15 Fumizonochou, Moriguchi City, Osaka, 570, Japan.
Akagi
K
K
Imamura
M
M
Nasu
R
R
Kimura
H
H
Nagata
K
K
Tanaka
Y
Y
D000818:Animals; D001783:Blood Flow Velocity; D003131:Combined Modality Therapy; D006863:Hydrogen-Ion Concentration / Q000528:radiation effects; D006979:Hyperthermia, Induced; D007083:Iliac Artery / Q000601:surgery; D007511:Ischemia; D008026:Ligation; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology / Q000628:therapy*; D011817:Rabbits; D016896:Treatment Outcome