title: Use of trans-Sialidase inhibition assay in a population serologically negative for Trypanosoma cruzi but at a high risk of infection.
abstract: trans-Sialidase inhibition assay (TIA) was employed in a population at high risk of Trypanosoma cruzi infection. From 20 serum samples that were negative by conventional serologic and parasitologic assays, 18 (90%) were reactive in TIA, providing further evidence of the higher sensitivity of TIA and suggesting that the actual prevalence of T. cruzi infection might be underestimated.
authors.affiliation: Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, Paraguay.
authors.forename: M S
authors.initials: MS
authors.lastname: Leguizamón
authors.forename: G
authors.initials: G
authors.lastname: Russomando
authors.forename: A
authors.initials: A
authors.lastname: Rojas de Arias
authors.forename: M
authors.initials: M
authors.lastname: Samudio
authors.forename: M
authors.initials: M
authors.lastname: Cabral
authors.forename: S M
authors.initials: SM
authors.lastname: González-Cappa
authors.forename: A C
authors.initials: AC
authors.lastname: Frasch
authors.forename: O
authors.initials: O
authors.lastname: Campetella
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000097:blood*; D006801:Humans; D009439:Neuraminidase; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods*; D014349:Trypanosoma cruzi / Q000302:isolation & purification*
chemical_list: D009439:Neuraminidase