Hypothesis: ceramide conditionally activates atypical protein kinases C, Raf-1 and KSR through binding to their cysteine-rich domains.
van Blitterswijk
W J
WJ
D000595:Amino Acid Sequence; D001665:Binding Sites; D002518:Ceramides / Q000378:metabolism* / Q000494:pharmacology*; D003545:Cysteine / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D008969:Molecular Sequence Data; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism*; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism*; D019908:Proto-Oncogene Proteins c-raf / Q000737:chemistry / Q000378:metabolism*
D002518:Ceramides; D011494:Protein Kinases; C097199:KSR-1 protein kinase; D019908:Proto-Oncogene Proteins c-raf; D011493:Protein Kinase C; D003545:Cysteine