title: Hepatitis G virus infection in primary Sjögren's syndrome: analysis in a series of 100 patients.
abstract: OBJECTIVE
  To determine the prevalence and clinical significance of hepatitis G virus (HGV) infection in a large cohort of patients with primary Sjögren's syndrome (SS).
  
  
  METHODS
  The study included 100 consecutive patients (92 female and eight male), with a mean age of 62 years (range 31-80) that were prospectively visited in our unit. All patients fulfilled the European Community criteria for SS and underwent a complete history, physical examination, as well as biochemical and immunological evaluation for liver disease. Two hundred volunteer blood donors were also studied. The presence of HGV-RNA was investigated in the serum of all patients and donors. Additionally, HBsAg and antibodies to hepatitis C virus were determined.
  
  
  RESULTS
  Four patients (4%) and six volunteer blood donors (3%) presented HGV-RNA sequences in serum. HGV infection was associated with biochemical signs of liver involvement in two (50%) patients. When compared with primary SS patients without HGV infection, no significant differences were found in terms of clinical or immunological features. HCV coinfection occurs in one (25%) of the four patients with HGV infection.
  
  
  CONCLUSIONS
  The prevalence of HGV infection in patients with primary SS is low in the geographical area of the study and HCV coinfection is very uncommon. HGV infection alone does not seen to be an important cause of chronic liver injury in the patients with primary SS in this area.
authors.affiliation: Systemic Autoimmune Diseases Unit, Hospital Clínic, Barcelona, Catalonia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Font
authors.forename: D
authors.initials: D
authors.lastname: Tàssies
authors.forename: M
authors.initials: M
authors.lastname: García-Carrasco
authors.forename: M
authors.initials: M
authors.lastname: Ramos-Casals
authors.forename: R
authors.initials: R
authors.lastname: Cervera
authors.forename: J C
authors.initials: JC
authors.lastname: Reverter
authors.forename: J M
authors.initials: JM
authors.lastname: Sánchez-Tapias
authors.forename: R
authors.initials: R
authors.lastname: Mazzara
authors.forename: M
authors.initials: M
authors.lastname: Ingelmo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018067:Flaviviridae / Q000235:genetics; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D012859:Sjogren's Syndrome / Q000150:complications* / Q000821:virology
chemical_list: D012367:RNA, Viral