title: Ischaemic preconditioning: present position and future directions.
abstract: Preconditioning the myocardium using short episodes of sublethal ischaemia will delay the onset of necrosis during a subsequent lethal ischaemic insult. This powerful protective adaptation of the myocyte has also been observed in other cell types. The potential for clinical application to benefit patients with a variety of pathological conditions has led to an expansion in our knowledge concerning the pathophysiology of ischemia-reperfusion injury and the regulatory mechanisms underlying cellular metabolism. We feel it is timely to assess the current position in this field and provide a critical appraisal to facilitate future research.
authors.affiliation: Hatter Institute for Cardiovascular Studies, University College London Hospitals, London, UK. s.bush-cavell@ucl.ac.uk
authors.forename: D M
authors.initials: DM
authors.lastname: Yellon
authors.forename: G F
authors.initials: GF
authors.lastname: Baxter
authors.forename: D
authors.initials: D
authors.lastname: Garcia-Dorado
authors.forename: G
authors.initials: G
authors.lastname: Heusch
authors.forename: M S
authors.initials: MS
authors.lastname: Sumeray
mesh_terms: D000818:Animals; D006801:Humans; D019194:Ischemic Preconditioning; D019157:Ischemic Preconditioning, Myocardial; D017202:Myocardial Ischemia / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D012106:Research; D015398:Signal Transduction
chemical_list: D015221:Potassium Channels; D018047:Receptors, Purinergic P1; D011493:Protein Kinase C