A comment on the analysis of bell-shaped dose-response curves.
A problem of the analysis of bell-shaped dose-response curves was theoretically discussed by using the response of ryanodine receptors for Ca2+ concentration as a model case. Usually the response curves were analyzed under the assumption that the receptor has a high affinity activation site and a low affinity inhibition site. However, a solution having a low affinity activation site and a high affinity inhibition site can be deduced theoretically from the same data. A method to avoid an erroneous result was proposed.
Kasai
M
M
Division of Biophysical Engineering, Graduate School of Engineering Science, Osaka University, Toyonaka, Japan.
D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008962:Models, Theoretical; D016011:Normal Distribution; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry / Q000187:drug effects*
D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium