title: Plasma cholecystokinin and gallbladder responses to increasing doses of bombesin in celiac disease.
abstract: Impaired postprandial gallbladder emptying in celiac disease has been attributed to an absence of appropriate cholecystokinin release. To determine if a flat jejunal mucosa in celiac patients is related to a reduced cholecystokinin-secreting capacity, increasing doses of bombesin were infused into six patients with celiac disease and a flat jejunal mucosa (group A), in seven celiac patients with a normal jejunal mucosa while on a gluten-free diet (group B), and in seven healthy controls (group C). Bombesin induced significant (P < 0.05) increments of plasma CCK to a maximum value of 1.0 +/- 0.3 pM in group A, to 1.5 +/- 0.3 pM in group B, and to 1.2 +/- 0.3 pM in group C (NS between groups), that were accompanied by significant (P < 0.05) gallbladder emptying responses of 70 +/- 4% in group A, 47 +/- 10% in group B and 65 +/- 5% in group C. Dose-response relationships were not different between groups. We conclude that there is no major impairment of gallbladder responsiveness to bombesin or of cholecystokinin-secreting capacity in patients with a flat jejunal mucosa due to celiac disease.
authors.affiliation: Department of Gastroenterology & Hepatology, University Hospital Nijmegen, The Netherlands.
authors.forename: P W
authors.initials: PW
authors.lastname: Thimister
authors.forename: W P
authors.initials: WP
authors.lastname: Hopman
authors.forename: G
authors.initials: G
authors.lastname: Rosenbusch
authors.forename: J B
authors.initials: JB
authors.lastname: Jansen
mesh_terms: D000328:Adult; D001839:Bombesin / Q000008:administration & dosage* / Q000494:pharmacology; D016022:Case-Control Studies; D002446:Celiac Disease / Q000473:pathology / Q000503:physiopathology*; D002766:Cholecystokinin / Q000097:blood* / Q000378:metabolism; D005260:Female; D016473:Gallbladder Emptying / Q000187:drug effects*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D007583:Jejunum / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D002766:Cholecystokinin; D001839:Bombesin