Dopamine synthesizing enzymes in paraventricular hypothalamic neurons of the human and monkey (Macaca fuscata).
Using immunohistochemistry, we demonstrated that paraventricular hypothalamic neurons immunoreactive for tyrosine hydroxylase (TH) were not immunopositive for the second step catecholamine synthesizing enzyme L-amino acid decarboxylase (AADC) in the human and monkey Macaca fuscata. In the latter species, they were not immunoreactive for dopamine. It is most likely that primate paraventricular TH-containing neurons do not synthesize dopamine.
Kitahama
K
K
Département de Médecine Expérimentale, INSERM U480, Faculté de Médecine, Université Claude Bernard, Lyon, France.
Ikemoto
K
K
Jouvet
A
A
Nagatsu
I
I
Geffard
M
M
Okamura
H
H
Pearson
J
J
D000328:Adult; D000368:Aged; D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000032:analysis / Q000378:metabolism; D004298:Dopamine / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D008251:Macaca / Q000378:metabolism*; D008875:Middle Aged; D009474:Neurons / Q000201:enzymology*; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D001142:Aromatic-L-Amino-Acid Decarboxylases; D004298:Dopamine