title: Use of fish oils appears to reduce infarct size as estimated from peak creatine kinase and lactate dehydrogenase activities.
abstract: In 753 patients with acute myocardial infarction, use of fish oils (FO, n = 242) before onset of infarction seemed to reduce infarct size as estimated from peak creatine kinase (CKmax) and lactate dehydrogenase (LDmax) activities. The study had an observational exposed/nonexposed design, and both crude and adjusted effects were looked for. CRUDE EFFECTS: In the restricted cohort of patients not receiving thrombolytic treatment (n = 411), FO reduced CKmax from 879 to 759 U/l (2 p = 0.030) and LDmax from 870 to 768 U/l (2 p = 0.011), respectively. More of these patients in the lowest enzyme quartiles used FO, p for linear trend was for CKmax 0.008 and for LDmax 0.06, respectively. ADJUSTED EFFECTS: In patients not receiving thrombolytic treatment, FO reduced CKmax (2 p = 0.007) and LDmax (2 p = 0.005), but in patients receiving such treatment, CKmax and LDmax values increased, 2 p being 0.036 and 0.097, respectively. In patients not receiving thrombolysis, FO increased the incidence of small infarcts (the 25% quartile), odds ratio for CKmax was 1.82 (2 p = 0.018) and for LDmax 1.66 (2 p = 0.048), respectively. The results indicate that FO may reduce infarct size and the incidence of large infarcts. In addition, FO seems to enhance the effect of thrombolysis.
authors.affiliation: Department of Pharmacotherapeutics, University of Oslo and Ullevål University Hospital, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Landmark
authors.forename: M
authors.initials: M
authors.lastname: Abdelnoor
authors.forename: P
authors.initials: P
authors.lastname: Urdal
authors.forename: B
authors.initials: B
authors.lastname: Kilhovd
authors.forename: H P
authors.initials: HP
authors.lastname: Dørum
authors.forename: N
authors.initials: N
authors.lastname: Borge
authors.forename: H
authors.initials: H
authors.lastname: Refvem
mesh_terms: D000368:Aged; D004796:Clinical Enzyme Tests; D015331:Cohort Studies; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D015912:Thrombolytic Therapy
chemical_list: D005395:Fish Oils; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase