title: Brain concentrations of asimadoline in mice: the influence of coadministration of various P-glycoprotein substrates.
authors.affiliation: Institute of Pharmacokinetics and Metabolism, Merck KGaA, Grafing, Germany.
authors.forename: H M
authors.initials: HM
authors.lastname: Bender
authors.forename: J
authors.initials: J
authors.lastname: Dasenbrock
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000081:Acetamides / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D000701:Analgesics, Opioid / Q000493:pharmacokinetics*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D016572:Cyclosporine / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004077:Digoxin / Q000494:pharmacology; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D017294:Ondansetron / Q000494:pharmacology; D010865:Pilot Projects; D011759:Pyrrolidines / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000081:Acetamides; D000701:Analgesics, Opioid; D000972:Antineoplastic Agents, Phytogenic; D002250:Carbon Radioisotopes; D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011759:Pyrrolidines; D012702:Serotonin Antagonists; D017294:Ondansetron; D014747:Vinblastine; D004077:Digoxin; D003907:Dexamethasone; D016572:Cyclosporine; C092095:asimadoline