Recurrent phyllodes tumor in a man.
The case of a 35-year-old man with a borderline-type cystosarcoma phyllodes is presented. Four years after the primary excision of the tumor, wide excision of a local recurrence and postoperative radiotherapy were performed. No repeated relapse was observed during a 5-year follow-up. Neither significant endocrine changes nor genetic alteration could be proven. However, a slightly increased SHBG concentration was detected, resulting in a decreased biologically available androgen level reduced testosterone/SHBG index. This phenomenon might be a consequence of the chronic liver disease of the patient due to his type II diabetes mellitus and alcohol abuse. In addition to the conventional histopathological examinations, immunohistochemical and electron-microscopic investigations were carried out on tissue sections, and the steroid receptors, EGF receptors and EGF-like activity of the tumor were also studied.
Kahán
Z
Z
Department of Oncotherapy, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Tószegi
A M
AM
Szarvas
F
F
Gaizer
G
G
Baradnay
G
G
Ormos
J
J
D000328:Adult; D018567:Breast Neoplasms, Male / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D012739:Gonadal Steroid Hormones / Q000032:analysis; D006801:Humans; D008297:Male; D003557:Phyllodes Tumor / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D010908:Pituitary Hormones, Anterior / Q000032:analysis; D013963:Thyroid Hormones / Q000032:analysis
D012739:Gonadal Steroid Hormones; D010908:Pituitary Hormones, Anterior; D013963:Thyroid Hormones