Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate/carboxymethylcellulose gel.
OBJECTIVE
To assess the efficacy of a bioabsorbable gel for reducing primary postoperative adhesions.


METHODS
A randomized, prospective, blinded study.


METHODS
Academic research environment.


METHODS
Forty-one New Zealand Rabbits.


METHODS
A chemically modified hyaluronate and carboxymethylcellulose (HA/CMC) gel formulation was applied to a bilateral uterine horn injury. Postoperative adhesions were assessed at a second-look laparoscopy.


METHODS
The uterine horn model was shown to be adhesiogenic, with 29 (70%) of 42 untreated uterine horns found to have adhesions. After gel treatment, 22 (55%) of 40 uterine horns were free of adhesions compared with 12 (30%) of 42 controls.


RESULTS
Animals treated with HA/CMC gel had significantly reduced postsurgical adhesion scores when compared with controls.


CONCLUSIONS
Treatment of injured uterine horn with HA/CMC gel resulted in a significant reduction in postoperative surgical adhesions.
Leach
R E
RE
Wayne State University, Detroit, Michigan, USA. rleach@cc.cms.wayne.educ
Burns
J W
JW
Dawe
E J
EJ
SmithBarbour
M D
MD
Diamond
M P
MP
D000818:Animals; D002266:Carboxymethylcellulose Sodium; D005260:Female; D005782:Gels; D006820:Hyaluronic Acid; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control*; D014591:Uterine Diseases / Q000517:prevention & control*; D014599:Uterus / Q000601:surgery
D005782:Gels; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium