title: [Local treatment of purulent chronic otitis media with ciprofloxacin].
abstract: We evaluated the efficacy of ciprofloxacin eardrops compared to tobramycin and to a placebo in the treatment of chronic suppurative otitis media. 60 ears were randomly assigned to treatment for 3 weeks with ciprofloxacin, tobramycin or placebo eardrops. The organism most commonly isolated from the ear discharge was Pseudomonas aeruginosa. The clinical responses were 78.9% and 72.2%, respectively, in the ciprofloxacin and tobramycin groups, while it was only 41.2% in the placebo group. Treatment with ciprofloxacin eardrops seemed to be at least as efficient as treatment with tobramycin. Considering the lack of ototoxicity of ciprofloxacin, this treatment may be best for chronic otitis media.
authors.affiliation: Dept. of Otolaryngology, Head and Neck Surgery, Bnai-Zion Medical Center, Technion, Haifa.
authors.forename: L
authors.initials: L
authors.lastname: Podoshin
authors.forename: A
authors.initials: A
authors.lastname: Brodzki
authors.forename: M
authors.initials: M
authors.lastname: Fradis
authors.forename: J
authors.initials: J
authors.lastname: Ben-David
authors.forename: J
authors.initials: J
authors.lastname: Larboni
authors.forename: I
authors.initials: I
authors.lastname: Srugo
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010035:Otitis Media, Suppurative / Q000188:drug therapy* / Q000382:microbiology; D019999:Pharmaceutical Solutions; D011552:Pseudomonas Infections / Q000188:drug therapy; D014031:Tobramycin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D019999:Pharmaceutical Solutions; D002939:Ciprofloxacin; D014031:Tobramycin