title: Postoperative interstitial radiotherapy of keloids by iridium 192: a retrospective study of 46 treated scars.
abstract: BACKGROUND
  Keloids are clinically vexacious scars characterized by a high recurrence rate after excision alone (50-100%). Many adjuvant techniques have been used with more or less convincing results.
  
  
  OBJECTIVE
  The aim of this study is to show the efficiency of keloidectomy and postoperative interstitial radiotherapy by an iridium 192 wire.
  
  
  METHODS
  During a 14-year period, 39 patients with keloids (46 keloids) were treated by this regimen. Seven patients had been previously treated by intralesional corticosteroids, surgery alone or postoperative interstitial radiotherapy, without improvement. A dose of 12 Gy (7 keloids) to 15 Gy (22 keloids) was delivered at a point 2.5 mm from the axis of the wire. For 17 keloids the dose schedule was 15 Gy at a point 5 mm to the wire. The median follow-up was 7 months.
  
  
  RESULTS
  The overall success rate is close to 63%. A recurrence occurred in 14 cases without relation to the method used, the age or the localization of the lesions. There were no side effects observed.
  
  
  CONCLUSIONS
  Postoperative interstitial radiotherapy represents an effective, unconstraining and safe treatment for keloids if the contraindications are respected.
authors.affiliation: Service de Radiothérapie, Hôpital Universitaire Dupuytren, Limoges, France.
authors.forename: P
authors.initials: P
authors.lastname: Clavere
authors.forename: C
authors.initials: C
authors.lastname: Bedane
authors.forename: J M
authors.initials: JM
authors.lastname: Bonnetblanc
authors.forename: A
authors.initials: A
authors.lastname: Bonnafoux-Clavere
authors.forename: J
authors.initials: J
authors.lastname: Rousseau
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D001918:Brachytherapy; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D007627:Keloid / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012008:Recurrence; D012189:Retrospective Studies; D012449:Safety; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007496:Iridium Radioisotopes; D019275:Radiopharmaceuticals