title: [Isotopic studies on the regeneration of stapedial bone in otosclerosis].
abstract: The aim of the study was determining the bone rebuilding activity in stapes and otosclerotic focus and comparison the relation between bone rebuilding activity with some clinical features such as the patient's sex and age, duration of the disease and the degree of hearing impairment. The study covered 98 patients aged from 18 to 68 years (X = 37 years) in whom, due to otosclerosis, stapedectomy was performed at the Clinic of Otolaryngology--PAM in Szczecin. The rebuilding activity was estimated in bone fragments having been removed during the operation, i.e. in 98 specimens of canal wall bone, 97 specimens of stapedial crura, 88 fragments from posterior and 18 fragments from anterior parts of footplate as well as in 15 otosclerotic foci, using isotopic method implementing a complex of pyrophosphate labelled with technetium Tc-99m. The degree of bone rebuilding activity was defined by the amount of absorbed isotopic index. The "control group" was made up of 9 cases, in which stapedectomy was carried out for therapeutical purpose in consequence of other ailments, namely: in 3 cases of congenital stapedial ankylosis, 5 cases of stapedial tympanosclerosis, and 1 case of Menier's disease. It has been disclosed that otosclerosis is an active pathological process, involving the bone of the entire stapes with the strongest manifestation in the disease focus. An essential fact was linked with the very low bone rebuilding activity in the stapedial footplate and crura in the "control group". The bone rebuilding activity in otosclerotic foci and footplate of stapes was somewhat higher in males than in females. It was the highest in patients whose disease duration was the longest. In general the bone rebuilding activity didn't influence the degree of hearing impairment.
authors.affiliation: Kliniki Otolaryngologii Pomorskiej Akademii Medycznej w Szczecinie.
authors.forename: A
authors.initials: A
authors.lastname: Konarska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001861:Bone Regeneration; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013199:Stapes / Q000000981:diagnostic imaging* / Q000473:pathology; D013201:Stapes Surgery; D016698:Technetium Tc 99m Pyrophosphate
chemical_list: D019275:Radiopharmaceuticals; D016698:Technetium Tc 99m Pyrophosphate
vernacular_title: Izotopowe badania aktywności przebudowy kości strzemiaczka w otosklerozie.