Assessment of growth potential by MIB-1 immunohistochemistry in ameloblastic fibroma and related lesions of the jaws compared with ameloblastic fibrosarcoma.
Specimens from two ameloblastic fibromas (including one recurrent case), two ameloblastic fibro-odontomas, and one ameloblastic fibrosarcoma were subjected to investigation by MIB-1 immunohistochemistry in order to elucidate the growth potential of these tumors. MIB-1 labeling indices in the epithelial component of these tumors ranged from 2.9 to 7.5%, whereas those in the mesenchymal component ranged from 1.5 to 13.5%. Of these, labeling indices in the mesenchymal component of the recurrent ameloblastic fibroma and ameloblastic fibrosarcoma were quite high. These findings suggest that evaluation of growth potential in ameloblastic fibroma and related lesions could be of help in understanding tumor aggressiveness and in selecting appropriate surgical procedures.
Sano
K
K
Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.
Yoshida
S
S
Ninomiya
H
H
Ikeda
H
H
Ueno
K
K
Sekine
J
J
Iwamoto
H
H
Uehara
M
M
Inokuchi
T
T
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D002455:Cell Division; D002648:Child; D003475:Curettage; D018572:Disease-Free Survival; D004848:Epithelium / Q000473:pathology; D005260:Female; D005404:Fixatives; D005500:Follow-Up Studies; D005557:Formaldehyde; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000473:pathology* / Q000601:surgery; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008648:Mesoderm / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009808:Odontogenic Tumors / Q000473:pathology* / Q000601:surgery; D010027:Osteotomy; D016612:Paraffin Embedding
D000911:Antibodies, Monoclonal; D005404:Fixatives; D019394:Ki-67 Antigen; D005557:Formaldehyde