title: Contemporary controversies in the management of congenital diaphragmatic hernia.
abstract: Congenital diaphragmatic hernia (CDH) has remained the most frustrating of the major birth defects to manage successfully. Despite the earlier detection of severe diaphragmatic defects by prenatal ultrasound, and the early recognition of CDH as a cause for respiratory distress presenting at birth, current mortality has improved little from the original series presented in 1940 by Ladd and Gross. This article discusses the difficulty in defining population with congenital diaphragmatic hernia, current controversies in the medical and surgical management of these patients, appropriate timing and usage of ECMO, a review of current, experimental therapies, and short-term and long-term outcomes of these patients.
authors.affiliation: Department of Surgery, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Katz
authors.forename: T E
authors.initials: TE
authors.lastname: Wiswell
authors.forename: S
authors.initials: S
authors.lastname: Baumgart
mesh_terms: D002658:Developmental Disabilities / Q000209:etiology; D015199:Extracorporeal Membrane Oxygenation; D005315:Fetal Diseases / Q000601:surgery; D005466:Fluorocarbons / Q000627:therapeutic use; D006548:Hernia, Diaphragmatic / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000627:therapeutic use; D011379:Prognosis; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012121:Respiration, Artificial; D014481:United States / Q000453:epidemiology
chemical_list: D005466:Fluorocarbons; D011663:Pulmonary Surfactants; D009569:Nitric Oxide