title: Successful treatment of in-transit metastases from Merkel's cell carcinoma with isolated hyperthermic limb perfusion.
abstract: Merkel's cell carcinoma is an uncommon neuroendocrine cutaneous neoplasm. An unusual mode of dissemination of this tumor is the phenomenon of in-transit metastases. We report complete resolution of in-transit metastases from a Merkel's cell carcinoma in response to treatment with isolated hyperthermic limb perfusion with melphalan. Limb perfusion appears to be a promising modality for such lesions.
authors.affiliation: Department of Surgery, Louisiana State University and the Stanley S. Scott Cancer Center, New Orleans 70112, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: Heinzman
authors.forename: E A
authors.initials: EA
authors.lastname: Levine
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D015266:Carcinoma, Merkel Cell / Q000188:drug therapy* / Q000473:pathology*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008207:Lymphatic Metastasis; D008297:Male; D008558:Melphalan / Q000008:administration & dosage*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan