title: Isolated tumor cells are frequently detectable in the peritoneal cavity of gastric and colorectal cancer patients and serve as a new prognostic marker.
abstract: OBJECTIVE
  To evaluate the prognostic significance of isolated tumor cells detected by a panel of various monoclonal antibodies.
  
  
  BACKGROUND
  Previously, we showed by using immunocytology that cancer cells are frequently found in bone marrow and peritoneal cavity samples of gastrointestinal cancer patients.
  
  
  METHODS
  Findings in bone marrow and peritoneal cavity samples were compared and correlated with the 4-year survival rate of 84 gastric and 109 colorectal patients with cancer.
  
  
  RESULTS
  Although positive results in the bone marrow showed little prognostic significance, the peritoneal cavity results correlated with the 4-year survival rate (gastric cancer: p = 0.0038; colorectal cancer: p = 0.0079). Additionally, in subgroups of patients with early (gastric cancer: p = 0.02, colorectal cancer: p = 0.48) and advanced (gastric cancer: p = 0.02, colorectal cancer: p < 0.0001) tumor stages, a correlation of immunocytologic findings and the survival rate was seen.
  
  
  CONCLUSIONS
  The detection of minimal residual disease in the peritoneal cavity serves as a new prognostic marker.
authors.affiliation: Department of Surgery, University Hospital Kiel, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Schott
authors.forename: I
authors.initials: I
authors.lastname: Vogel
authors.forename: U
authors.initials: U
authors.lastname: Krueger
authors.forename: H
authors.initials: H
authors.lastname: Kalthoff
authors.forename: H W
authors.initials: HW
authors.lastname: Schreiber
authors.forename: W
authors.initials: W
authors.lastname: Schmiegel
authors.forename: D
authors.initials: D
authors.lastname: Henne-Bruns
authors.forename: B
authors.initials: B
authors.lastname: Kremer
authors.forename: H
authors.initials: H
authors.lastname: Juhl
mesh_terms: D015179:Colorectal Neoplasms / Q000401:mortality* / Q000473:pathology*; D006801:Humans; D010537:Peritoneum / Q000473:pathology*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology*; D015996:Survival Rate