TGF-beta in glomerular disease.
Transforming growth factor-beta (TGF-beta) is an important cytokine in glomerular disease. Its major role may be to mediate extracellular matrix deposition, by both increasing the synthesis of matrix components and by reducing their degradation. Strong evidence supports the functional role for TGF-beta in mesangial matrix expansion. However, TGF-beta may also have other important functions in the glomerulus, including the regulation of cell proliferation, hypertrophy, and survival (apoptosis), as well as modulation of the local and systemic immune response.
Shankland
S J
SJ
Department of Medicine, University of Washington, Seattle 98195, USA. stuartjs@u.washington.edu
Johnson
R J
RJ
D000818:Animals; D002455:Cell Division; D002470:Cell Survival; D005109:Extracellular Matrix / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005920:Glomerular Mesangium / Q000473:pathology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta