title: [Therapeutic effect of zuclopenthixol acetate on positive and negative symptoms in schizophrenia].
abstract: Fifty schizophrenic in-patients (DSM-IV) were treated in an open study with zuclopenthixol acetate. Mental status, improvement and side-effects were measured before administration of the drug as well as after the 1st, 2nd and 3rd injection. Positive and negative symptoms were evaluated with the use of PANSS. 60% of patients received three injections. Usually the intervals between injections lasted 48 hours. The improvement after the 3rd injection of zuclopenthixol acetate was found in 80% of patients. All positive symptoms improved after the treatment (p < 0.001), among them excitement (54% reduction vs. baseline), hostility (49%) suspiciousness/persecution (45%). The study revealed that parallel to the decrease of positive symptoms, the severity of negative symptoms also decreased, in particular: difficulty in abstract thinking (28%) and stereotyped thinking (27%) (p < 0.001). Passive/apathetic social withdrawal and lack of spontaneity as well as flow of conversation only slightly improved (p < 0.05). 50% of patients experienced side-effects--usually extrapyramidal reactions.
authors.affiliation: III Klinika Psychiatrii IPiN w Warszawie.
authors.forename: T
authors.initials: T
authors.lastname: Szafrański
authors.forename: M
authors.initials: M
authors.lastname: Jarema
authors.forename: J
authors.initials: J
authors.lastname: Białek
authors.forename: M
authors.initials: M
authors.lastname: Buksowicz
authors.forename: E
authors.initials: E
authors.lastname: Marciniak
authors.forename: M E
authors.initials: ME
authors.lastname: Choma
authors.forename: A
authors.initials: A
authors.lastname: Ruzikowska
authors.forename: M
authors.initials: M
authors.lastname: Milej
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003006:Clopenthixol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; C060342:clopenthixol acetate ester; D003006:Clopenthixol
vernacular_title: Ocena wpływu terapeutycznego octanu zuklopentyksolu na objawy pozytywne i negatywne w schizofrenii.