Granulocytic ehrlichiosis in tick-immune guinea pigs.
We investigated whether Ixodes scapularis-mediated host immunity interrupts transmission of the agent of human granulocytic ehrlichiosis (aoHGE) to guinea pigs. Ticks infected with aoHGE readily transmitted aoHGE to tick-immune guinea pigs, despite incomplete tick engorgement and host attachment. Although tick immunity can prevent Lyme borreliosis, protection is not afforded against granulocytic ehrlichiosis.
Das
S
S
Department of Internal Medicine, Yale University, New Haven, Connecticut 06520-8031, USA.
Deponte
K
K
Marcantonio
N L
NL
Ijdo
J W
JW
Hodzic
E
E
Katavolos
P
P
Barthold
S W
SW
Telford
S R
SR
Kantor
F S
FS
Fikrig
E
E
D000818:Animals; D016873:Ehrlichiosis / Q000517:prevention & control* / Q000635:transmission; D005260:Female; D006168:Guinea Pigs; D018922:HL-60 Cells; D006801:Humans; D015151:Immunoblotting; D018884:Ixodes / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D016513:Mice, SCID; D016133:Polymerase Chain Reaction