In situ localization of ACTH receptor-like mRNA in molluscan and human immunocytes.
Adrenocorticotropin hormone (ACTH) receptor-like messenger RNA was localized in molluscan hemocytes and human peripheral blood mononuclear cells by in situ hybridization using a digoxigenin-labelled bovine complementary DNA probe. These findings suggest that the ACTH receptor gene has been highly conserved during evolution. Moreover, these data represent further support for a relationship between the immune and neuroendocrine systems in invertebrates, as documented in our previous studies.
Ottaviani
E
E
Department of Animal Biology, University of Modena, Italy. enzott@unimo.it
Franchini
A
A
Hanukoglu
I
I
D000818:Animals; D015870:Gene Expression / Q000235:genetics; D006434:Hemocytes / Q000737:chemistry* / Q000166:cytology; D006801:Humans; D017403:In Situ Hybridization; D007963:Leukocytes, Mononuclear / Q000737:chemistry* / Q000166:cytology; D008974:Mollusca / Q000276:immunology*; D012333:RNA, Messenger / Q000378:metabolism*; D018043:Receptors, Corticotropin / Q000235:genetics*
D012333:RNA, Messenger; D018043:Receptors, Corticotropin