Simple look-up table of optimized dwell time intervals using a high-dose-rate remote afterloader for endovascular irradiation.
OBJECTIVE
This article's objective is to develop a simple methodology deliver a uniform radiation dose to the wall of a narrow peripheral artery for preventing restenosis using a high-dose-rate (HDR) 192Ir remote afterloader.


METHODS
Based upon published two-dimensional data such as anisotropy factors of an HDR 192Ir source calculated from the Monte-Carlo method, arterial wall doses at a close range from an HDR source may be easily calculated using the special formula suggested in Task Group Report No. 43 published by the American Association of Physicists in Medicine. An optimization procedure was used to calculate the optimized dwell times for delivering a uniform dose along arterial walls for various arterial diameters and lengths of lesions.


RESULTS
Based on lengths of the stenosis and diameters of arteries or angioplasty balloons, a set of simple look-up tables for optimal dwell time intervals of endovascular radiation treatment have been developed for the MicroSelectron HDR remote afterloader.


CONCLUSIONS
Doses for endovascular irradiation have been accurately calculated with anisotropy factors. For delivering uniform doses along the arterial wall, a set of look-up tables listed for optimal dwell times is available for the HDR remote afterloader.
Wu
A
A
Department of Radiation Oncology, Allegheny General Hospital, Allegheny University of the Health Sciences, Pittsburgh, PA 15212, USA.
Arshoun
Y
Y
Izadbakhsh
M
M
Kalnicki
S
S
D001157:Arterial Occlusive Diseases / Q000517:prevention & control / Q000532:radiotherapy*; D001918:Brachytherapy / Q000379:methods*; D004730:Endothelium, Vascular / Q000528:radiation effects; D005263:Femoral Artery / Q000528:radiation effects; D006801:Humans; D007223:Infant; D007496:Iridium Radioisotopes / Q000008:administration & dosage*; D016491:Peripheral Vascular Diseases / Q000517:prevention & control / Q000532:radiotherapy; D011150:Popliteal Artery / Q000528:radiation effects; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D011879:Radiotherapy Dosage; D012008:Recurrence; D013997:Time Factors
D007496:Iridium Radioisotopes; D019275:Radiopharmaceuticals