[Antioxidant probucol: effects on free radical lipid peroxidation, blood rheology and course of angina pectoris].
OBJECTIVE
Study of the effect of antioxidant probucol on free-radical lipid peroxidation, blood rheology, and course of angina pectoris in coronary patients.


METHODS
The above parameters and clinical hemodynamic values were monitored over the course of probucol therapy in 48 men (mean age 54.8 +/- 1.3 years) with coronary disease and angina of effort of the II-III functional class.


RESULTS
Long therapy with probucol effectively inhibited free-radical lipid peroxidation, normalized lipid spectrum of the blood, and had a favorable impact on the course of angina pectoris.


CONCLUSIONS
Probucol stabilizes the structure and function of red cells and platelets in coronary patients.
Zakirova
A N
AN
Shamaev
A G
AG
Mirionkova
N A
NA
D000787:Angina Pectoris / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D015716:Electrocardiography, Ambulatory; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005080:Exercise Test; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000037:antagonists & inhibitors* / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011341:Probucol / Q000008:administration & dosage / Q000627:therapeutic use*; D012212:Rheology / Q000187:drug effects*; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; D016166:Free Radical Scavengers; D008055:Lipids; D011341:Probucol
Antioksidant probukol: vliianie na svobodnoradikal'noe peroksidnoe okislenie lipidov, reologicheskie svoĭstva krovi i techenie stenokardii.