Antigenic structure of foot and mouth disease virus type A22 (Indian isolates).
Variations in foot and mouth disease virus are due to amino acid substitutions in the VP1, which is a major immunogen. Analysis of this hypervariable region is essential to know the antigenic structure of the serotype and is necessary to select a suitable vaccine strain. FMDV type A22 is one of the four prevailing virus types for which the vaccine is used regularly. To understand the antigenic structure of this type, carboxy- terminal region of VP1 from two field isolates and vaccine virus were sequenced and analysed. The results indicate that, Indian A22 has distinct antigenic structure.
Tulasiram
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Indian Veterinary Research Institute, Bangalore, Hebbal, India.
Suryanarayana
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D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics*; D005537:Aphthovirus / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D001483:Base Sequence; D002213:Capsid / Q000235:genetics / Q000276:immunology; D036022:Capsid Proteins; D002417:Cattle; D002418:Cattle Diseases / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D005536:Foot-and-Mouth Disease / Q000821:virology; D016056:Immunodominant Epitopes / Q000235:genetics; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D000956:Antigens, Viral; D036022:Capsid Proteins; D004279:DNA, Viral; D016056:Immunodominant Epitopes; C442501:VP1 protein, Foot-and-mouth disease virus