title: Hirunorms, novel hirudin-like direct thrombin inhibitors.
abstract: 1. Hirunorms are new synthetic peptides designed to interact with thrombin in a similar way to the natural inhibitor hirudin. 2. Hirunorms are specific and efficient in vitro inhibitors of thrombin activity. 3. Hirunorms are potent anticoagulant and antithrombotic agents in in vivo experimental models devoid of hemorrhagic effects at doses that are active in preventing thrombosis.
authors.affiliation: Dipartimento di Fisiologia e Biochimica, Università di Pisa, Italy. cmario@dfb.unipi.it
authors.forename: M
authors.initials: M
authors.lastname: Cappiello
authors.forename: P G
authors.initials: PG
authors.lastname: Vilardo
authors.forename: A
authors.initials: A
authors.lastname: Del Corso
authors.forename: U
authors.initials: U
authors.lastname: Mura
mesh_terms: D000991:Antithrombins / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006629:Hirudins / Q000031:analogs & derivatives*; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D013917:Thrombin / Q000037:antagonists & inhibitors*; D013927:Thrombosis / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000991:Antithrombins; D006629:Hirudins; D010455:Peptides; C102452:hirunorm; C102451:hirunorm IV; D013917:Thrombin