title: [The differential gene expression of the Six family during limb regeneration and development in amphibians].
abstract: Differential expression of homeobox genes of the Six family, homologues of Drosophila gene sine oculis, was revealed during limb regeneration of ribbed newt Pleurodeles waltlii and common frog Rana temporaria. Expression of these genes correlated to regeneration capacity in the studied animals. The primary structure of the most conservative region in the identified genes has been determined. We assessed the differences in the primary structure of Six family genes obtained from regenerating limbs of the newt and frog (86 and 94.9% similarity at the nucleotide and amino acid levels, respectively). Comparison of the obtained and published sequences of Six family genes has demonstrated that they are most similar to mouse gene Six1 (84.2 and 82.8% nucleotide sequence similarity in the frog and newt, respectively, and 99.2 and 94.1% amino acid sequence similarity in the frog and newt, respectively.
authors.affiliation: Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Znoĭko
authors.forename: S L
authors.initials: SL
authors.lastname: Znoĭko
authors.forename: R D
authors.initials: RD
authors.lastname: Zinov'eva
authors.forename: V I
authors.initials: VI
authors.lastname: Mitashov
mesh_terms: D000595:Amino Acid Sequence; D000663:Amphibians / Q000235:genetics* / Q000502:physiology; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005121:Extremities / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics* / Q000502:physiology; D005801:Genes, Homeobox / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics* / Q000502:physiology; D010999:Pleurodeles; D016133:Polymerase Chain Reaction / Q000379:methods; D012313:RNA / Q000235:genetics; D011896:Rana temporaria; D012038:Regeneration / Q000235:genetics* / Q000502:physiology
chemical_list: D012313:RNA; D004247:DNA
vernacular_title: Differentsial'naia ékspressiia genov semeĭstva Six v khode regeneratsii i razvitiia konechnosti amfibiĭ.