[P73: a kin to the p52 tumor suppressor gene].
A gene with remarkable sequence homology with the tumour suppressor gene p53 is located at the tip of the short arm of human chromosome 1 which is often found to be deleted in neuroblastomas, melanomas and breast cancers. Despite their structural and functional similarities, p53 and p73 may have distinct roles in cell grow regulation.
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Sanofi Recherche, Labège Innopole.
D002455:Cell Division / Q000235:genetics / Q000502:physiology; D002878:Chromosomes, Human, Pair 1; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D016147:Genes, Tumor Suppressor; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology; D025521:Tumor Suppressor Proteins
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins
p73: un cousin du gène suppresseur de tumeur p53.