title: Structure and function of bacterial cytochrome c oxidase.
abstract: The crystal structure of cytochrome c oxidase from the soil bacterium Paracoccus denitrificans has been reported. This structure has provided a basis for understanding the mechanism of the redox-coupled transmembrane proton pump which is the key component of the respiratory chain in most aerobic organism. Over the past ten years, there have been many site-directed mutagenesis studies performed on bacterial oxidases. Structural features of Paracoccus oxidase have been summarized in the light of these mutagenesis studies and other structural works.
authors.affiliation: Uppsala University, Department of Biochemistry, Biomedical Center, BOX 756 S-75123 Uppsala, Sweden. iwata@xray.bmc.uu.se
authors.forename: S
authors.initials: S
authors.lastname: Iwata
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D001665:Binding Sites; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006418:Heme; D008958:Models, Molecular; D010230:Paracoccus / Q000201:enzymology; D011487:Protein Conformation; D011522:Protons
chemical_list: D001426:Bacterial Proteins; D011522:Protons; D006418:Heme; D003576:Electron Transport Complex IV