title: The prevalence of toxoplasma antibodies in pregnant Nigerian women and the occurrence of stillbirth and congenital malformation.
abstract: Toxoplasma antibody serological tests were carried out using the Dye test on sera of pregnant and postpartum Nigerian women to investigate whether there was any association between the levels of antibody titres and the occurrence of stillbirths and congenital malformations. There was a high prevalence of toxoplasma antibodies in the sera of both pregnant and postpartum women. The prevalence rates for the pregnant women ranged from 72.5% to 88.8% with an overall rate of 75.4%; whilst for the postpartum women, the prevalence rates ranged from 75.0% to 94.4% with an overall rate of 80.5%. The toxoplasma antibody titres of the sera from the live-born babies as well as stillbirths and congenitally malformed babies ranged from 1:16 to 1:1024. The exact role played by toxoplasma in the occurrence of stillbirths and congenital malformation in our area of study is, however, not clear. For future research, it is suggested that larger samples be studied in order to enhance the validity of the findings of the present study.
authors.affiliation: Department of Preventive and Social Medicine, University College Hospital, Ibadan, Nigeria.
authors.forename: M O
authors.initials: MO
authors.lastname: Onadeko
authors.forename: D H
authors.initials: DH
authors.lastname: Joynson
authors.forename: R A
authors.initials: RA
authors.lastname: Payne
authors.forename: J
authors.initials: J
authors.lastname: Francis
mesh_terms: D000293:Adolescent; D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood*; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D049590:Postpartum Period; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology*; D015995:Prevalence; D014123:Toxoplasmosis / Q000453:epidemiology* / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan