title: A comparative study of the analgesic and anti-inflammatory activities of pectolinarin isolated from Cirsium subcoriaceum and linarin isolated from Buddleia cordata.
abstract: The dried aqueous extract of aerial parts of Cirsium subcoriaceum (Asteraceae) and its major flavonoid glycoside, pectolinarin, have been evaluated for analgesic and anti-inflammatory effects in mice and rats, respectively. Both the extract and pectolinarin exerted significant and dose-dependent analgesic and anti-inflammatory activities. Also, the anti-inflammatory activities of an aqueous extract of Buddleia cordata and its principal glycoside linarin were evaluated. The results of pharmacological testing proved that linarin is a better anti-inflammatory agent than pectolinarin and indomethacin. On the other hand, pectolinarin exerted a better analgesic effect than linarin.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Coyoacán, México.
authors.forename: M
authors.initials: M
authors.lastname: Martínez-Vázquez
authors.forename: T O
authors.initials: TO
authors.lastname: Ramírez Apan
authors.forename: A L
authors.initials: AL
authors.lastname: Lastra
authors.forename: R
authors.initials: R
authors.lastname: Bye
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D002867:Chromones / Q000302:isolation & purification / Q000494:pharmacology*; D004487:Edema; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010146:Pain; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D006027:Glycosides; C052786:pectolinarin; D009020:Morphine; C008282:linarin; D001241:Aspirin