Human herpesvirus 8 (HHV-8) in the pathogenesis of Kaposi's sarcoma and other diseases.
The discovery of Kaposi's Sarcoma-associated herpesvirus/human herpesvirus-8 (KSHV/ HHV-8) and subsequent studies of this virus have provided a body of evidence that support the concept that this is an etiologic agent for Kaposi's sarcoma (KS). Several studies have indicated that this virus may also be a causal agent for primary effusion lymphoma (PEL) and Castleman's disease as well. First generation serologic assays for HHV-8 have now been developed. The preponderance of data suggest that the incidence of HHV-8 infection is highest in populations at risk for KS: male homosexuals, immunosuppressed patients, and those who live in endemic regions. HHV-8 encodes for functional homologs of human proteins that may play a role in the development of disease. As we learn more about the steps by which this virus can lead to KS and/or other diseases, rational therapies and preventative strategies may be possible.
Humphrey
R W
RW
HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA.
Davis
D A
DA
Newcomb
F M
FM
Yarchoan
R
R
D005871:Castleman Disease / Q000453:epidemiology / Q000821:virology; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000145:classification / Q000472:pathogenicity*; D006801:Humans; D015994:Incidence; D008223:Lymphoma / Q000453:epidemiology / Q000821:virology; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology / Q000821:virology; D008297:Male; D010802:Phylogeny; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000821:virology*