title: Alteration of cerebral blood flow in patients with bacterial and viral meningoencephalitis.
abstract: OBJECTIVE
  Our purpose was to investigate cerebral blood flow disturbances in patients with bacterial and viral meningoencephalitis.
  
  
  METHODS
  Forty-two patients with acute bacterial and viral meningoencephalitis and 14 control subjects were studied using 99mTc-hexamethylpropyleneamine oxime (HMPAO) single-photon emission computed tomography (SPECT). SPECT images were evaluated semiquantitatively. The results were compared with clinical severity of the meningoencephalitis assessed at the time of the SPECT study with the Hunt and Hess scale, with separately recorded focal clinical signs, and with the Glasgow outcome scale (GOS) after 3 weeks.
  
  
  RESULTS
  Count density values were significantly reduced in patients with bacterial meningoencephalitis as compared with the control subjects. Inhomogeneous tracer accumulation assessed by asymmetry indexes was significantly greater in patients than in the control group. With increasing Hunt and Hess scores, the count density values decreased and the asymmetry indexes increased. Patients with a poor outcome (GOS 1 to 3) had significantly higher asymmetry indexes and lower CDV values than did patients with a good outcome.
  
  
  CONCLUSIONS
  Global and focal alterations of cerebral perfusion are frequent in bacterial and viral meningoencephalitis and correlate with acute clinical state.
authors.affiliation: Department of Neurology, University Hospital of the Saarland, Homburg/Saar, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Merkelbach
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: G
authors.initials: G
authors.lastname: Huber
authors.forename: K
authors.initials: K
authors.lastname: Schimrigk
mesh_terms: D000328:Adult; D001424:Bacterial Infections; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000821:virology*; D008875:Middle Aged; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014777:Virus Diseases
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime