title: An increased risk of cervical intra-epithelial neoplasia grade II-III among human papillomavirus positive patients with the HLA-DQA1*0102-DQB1*0602 haplotype: a population-based case-control study of Norwegian women.
abstract: Several recent studies have reported different associations between HLA specificities and human papillomavirus (HPV)-associated disease of the cervix. We report the distribution of DQA1 and DQB1 genes and HPV infection in a population-based case-control study including 92 patients with histologically verified cervical intraepithelial neoplasia grade II-III (CIN II-III) (thus including moderate and severe dysplasia and carcinoma in situ) and 225 control subjects. We found an overrepresentation of the DQA1*0102-DQB1*0602 haplotype among HPV-positive cases compared with controls. The association was even stronger when comparing HPV-16-positive cases with HPV-16-positive controls. In addition, among HPV-16-positive individuals, we observed a decreased frequency of DQA1*0102-DQB1*0604 in cases compared with controls. We were not able to detect any association between CIN II-III and DQB1*03. Compared with previous findings in cervical cancer, our data indicate that carrying the DQA1*0102-DQB1*0602 haplotype gives an increased risk of developing CIN when infected with HPV-16, without influencing progression to cancer.
authors.affiliation: Department of Genetics, Institute of Cancer Research, the Norwegian Radiumhospital, Oslo.
authors.forename: A
authors.initials: A
authors.lastname: Helland
authors.forename: A O
authors.initials: AO
authors.lastname: Olsen
authors.forename: K
authors.initials: K
authors.lastname: Gjøen
authors.forename: H E
authors.initials: HE
authors.lastname: Akselsen
authors.forename: T
authors.initials: T
authors.lastname: Sauer
authors.forename: P
authors.initials: P
authors.lastname: Magnus
authors.forename: A L
authors.initials: AL
authors.lastname: Børresen-Dale
authors.forename: K S
authors.initials: KS
authors.lastname: Rønningen
mesh_terms: D000328:Adult; D002278:Carcinoma in Situ / Q000235:genetics / Q000821:virology; D016022:Case-Control Studies; D005260:Female; D006681:HLA-D Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D009664:Norway; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000821:virology*
chemical_list: D006681:HLA-D Antigens