[Clinical and biochemical features of atherosclerosis main risk factors in children of probands with primary hyperlipidemia].
OBJECTIVE
Study of the incidence of hyperlipidemias and coronary atherosclerosis risk factors.


METHODS
A clinical and biochemical study of 35 children (25 men and 10 women aged 6 to 27 years) from 30 families of probands with primary hyperlipoproteinemias (HLP) was carried out. Use of modified risk factors (RF) in the examined group permitted the detection of hypodynamia in 25 subjects, obesity in 4, alcohol abuse and tobacco smoking in 1, and disorders of lipid metabolism in 31 (88%) cases.


RESULTS
Hypercholesterolemia was detected in 26 examinees, combined HLP in 1, hypoalphacholesterolemia in 3, and type V hyperlipoproteinemia in 1 case. The level of lipoprotein (a) was increased and positively correlated with xanthomatosis and the age of examinees. The level of basal immunoreactive insulin was within the normal range of values. Analysis of the relationship of this parameter and other coronary atherosclerosis RF revealed a correlation of the level of immunoreactive insulin and content of blood low-density lipoprotein cholesterol. In only 2 of the 30 examined families of probands with primary HLP there were no disorders of lipid metabolism and other modified RF.


CONCLUSIONS
Children, adolescents, and young people from families with primary HLP represent a risk group; they are to be regularly examined in order to prevent coronary disease and atherosclerosis and to detect and treat it in time.
Alidzhanova
Kh G
KhG
Tvorogova
M G
MG
Rozhkova
T A
TA
Balakhonova
T V
TV
Vorob'eva
L P
LP
Masenko
V P
VP
Kukharchuk
V V
VV
D000293:Adolescent; D000328:Adult; D002648:Child; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D006950:Hyperlipidemia, Familial Combined / Q000097:blood / Q000150:complications*; D007328:Insulin / Q000097:blood / Q000276:immunology; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011863:Radioimmunoassay; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
Kliniko-biokhimicheskie osobennosti osnovnykh faktorov riska ateroskleroza u deteĭ probandov s pervichnymi giperlipidemiiami.