title: Locally delivered antimicrobials in periodontal therapy.
abstract: The rapid growth in our understanding of the pathogenesis of periodontal disease has led to a change in therapeutic emphasis, supplementing traditional, non-specific, mechanical plaque control with a more focused targeting of pathogenic organisms. New topical preparations provide high antimicrobial doses at diseased sites without the systemic antibiotic loading which is now, in itself, a cause of concern due to the increasing tendency of micro-organisms to become resistant to antimicrobial agents. This article reviews the current methods of delivering antimicrobial agents to the gingival crevice and evaluates their roles in practical periodontal therapy.
authors.affiliation: Quayside Dental Centre, Manchester.
authors.forename: P R
authors.initials: PR
authors.lastname: Greene
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D000994:Antitrichomonal Agents / Q000008:administration & dosage; D002710:Chlorhexidine / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005782:Gels; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D010510:Periodontal Diseases / Q000188:drug therapy*; D010514:Periodontal Pocket / Q000188:drug therapy; D013754:Tetracyclines
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000994:Antitrichomonal Agents; D005782:Gels; D013754:Tetracyclines; D008795:Metronidazole; D002710:Chlorhexidine