title: Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade.
abstract: We analyzed 72 primary and 25 recurrent glioblastoma multiforme (GBM) samples for DNA sequence copy number abnormalities (CNAs) by comparative genomic hybridization (CGH). The number of aberrations per tumor ranged from 2 to 23 in primary GBM and 5 to 25 in recurrent GBM. There were 26 chromosome regions with CNAs in more than 20% of tumors. 7q22-36 was the most common gain and 10q25-26 was the most common loss; each occurred in more than 70% of tumors. Of 27 amplification sites, epidermal growth factor receptor (EGFR) was the most common; it was observed in 25% of primary GBMs. Statistical analysis based on pairwise correlation of CNAs indicated that there is more than one class of primary GBM.
authors.affiliation: Department of Laboratory Medicine, UCSF Cancer Center, USA.
authors.forename: G
authors.initials: G
authors.lastname: Mohapatra
authors.forename: A W
authors.initials: AW
authors.lastname: Bollen
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Lamborn
authors.forename: D H
authors.initials: DH
authors.lastname: Moore
authors.forename: M D
authors.initials: MD
authors.lastname: Prados
authors.forename: B G
authors.initials: BG
authors.lastname: Feuerstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005784:Gene Amplification; D017353:Gene Deletion; D018628:Gene Dosage; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009693:Nucleic Acid Hybridization