title: Effects of corticotropin-releasing factor on feeding and pancreatic polypeptide response in the dog.
abstract: We have previously reported that corticotropin-releasing factor (CRF) is a potent stimulator of adrenocorticotropic hormone and cortisol secretion in the dog. Therefore, in the present study, we investigated the extrahypophysiotropic actions of CRF in this species. When CRF was injected into the third cerebral ventricle, it failed to inhibit food intake significantly at doses of 1.19, 3.57, and 11.9 nmol. This is in sharp contrast with the results in rodents. At the 3.57 and 11.9 nmol doses, CRF markedly stimulated the secretion of pancreatic polypeptide (PP), a hormone under vagal control, and at the highest dose CRF increased plasma glucose levels. These results suggest species differences in the feeding response to CRF and activation of the parasympathetic nervous system in the dog.
authors.affiliation: Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Okita
authors.forename: A
authors.initials: A
authors.lastname: Inui
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Mizuuchi
authors.forename: K
authors.initials: K
authors.lastname: Banno
authors.forename: S
authors.initials: S
authors.lastname: Baba
authors.forename: M
authors.initials: M
authors.lastname: Kasuga
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D004285:Dogs; D004435:Eating / Q000187:drug effects*; D007276:Injections, Intraventricular; D010191:Pancreatic Polypeptide / Q000097:blood / Q000378:metabolism*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology; D013268:Stimulation, Chemical
chemical_list: D001786:Blood Glucose; D010276:Parasympatholytics; D010191:Pancreatic Polypeptide; D001285:Atropine; D003346:Corticotropin-Releasing Hormone