Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome.
Visual disturbance, hypertension, convulsions, and unconsciousness developed in a 70-year-old man after cisplatin chemotherapy and upper-limb amputation for osteosarcoma. MR imaging revealed bilateral reversible abnormalities in the occipital, parietal, and frontal white matter. Clinical and neuroradiologic features corresponded to reversible posterior leukoencephalopathy syndrome (RPLS), which some immunosuppressive and chemotherapeutic drugs have been reported to trigger. Cisplatin may be among these drugs. Our patient also had hypomagnesemia, which may have figured in the pathophysiology.
Ito
Y
Y
Department of Neurology, Nagoya University School of Medicine, Japan.
Arahata
Y
Y
Goto
Y
Y
Hirayama
M
M
Nagamutsu
M
M
Yasuda
T
T
Yanagi
T
T
Sobue
G
G
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D002945:Cisplatin / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male
D000970:Antineoplastic Agents; D002945:Cisplatin