[Systemic analysis of neuroimmune mechanisms of memory].
Administration of IL-1 beta and 125-129 fragment of alpha 2-interferon improved learning and retention of active avoidance behaviour in memory in rats. It also improved the correlation between intersignal runs and success of the avoidance behaviour learning. The data obtained suggest that an activation of the intersignal retention process is one of the mechanisms of the immunomodulators effect on learning and memory.
Zhuravlev
B V
BV
P. K. Anokhin Institute of Normal Physiology, Russian Acad. Med. Sci., Moscow, Russia.
Murtazina
E P
EP
Sulin
V Iu
VIu
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003213:Conditioning, Psychological / Q000187:drug effects; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects; D007370:Interferon Type I / Q000494:pharmacology*; D016898:Interferon-alpha; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000502:physiology*; D015213:Neuroimmunomodulation / Q000187:drug effects* / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D011994:Recombinant Proteins; D013598:Systems Theory; D014828:Vocalization, Animal / Q000187:drug effects
D000276:Adjuvants, Immunologic; D007370:Interferon Type I; D016898:Interferon-alpha; D007375:Interleukin-1; D010446:Peptide Fragments; D011994:Recombinant Proteins; C111627:interferon, alfa 2(125-129)
Sistemnyĭ analiz neĭroimmunologicheskikh mekhanizmov pamiati.