Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3'-azido-3'-deoxythymidine.
The effect of zidovudine (3'-azido-3'-deoxythymidine; AZT) was investigated in four breast cancer cell lines, a T4 cell leukemia, and a normal breast cell line in vitro. AZT inhibited the growth of all tumoral cell lines, but it did so in a wide range of concentrations. The growth of a normal breast cell line was also inhibited, although it required a much higher concentration. Furthermore, AZT inhibited colony formation in soft agar and telomerase activity. These results indicated that AZT can be potentially used, alone or in combination, as an anti-breast cancer agent.
Melana
S M
SM
Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.
Holland
J F
JF
Pogo
B G
BG
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D001940:Breast / Q000166:cytology / Q000187:drug effects; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002999:Clone Cells; D005260:Female; D006801:Humans; D019098:Telomerase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured; D015215:Zidovudine / Q000494:pharmacology*
D000964:Antimetabolites, Antineoplastic; D015215:Zidovudine; D019098:Telomerase