title: [Systemic embolism in a renal transplant patient. Echocardiographic demonstration of bronchial carcinoma with intracardiac invasion].
abstract: A 45 year old female renal transplant patient was admitted for subacute ischaemia of a lower limb. Echocardiography was performed and showed the presence of bronchial carcinoma with intracardiac invasion. The tumour was confirmed by thoracic computerised tomography and by bronchoscopy. Histological investigation of bronchial biopsies and of the arterial embolism extracted at surgery showed large cell malignant disease. The tumour partially responded to chemotherapy and the patient survived for 5 months. Extension of a bronchial carcinoma to the left atrium is a classical complication in autopsy reports but rarely a source of systemic embolism. Echocardiographic diagnosis of this condition is very rare. The incidence of malignant diseases is higher in renal transplant patients than in the general population but this has not been verified for bronchial carcinoma. Echocardiography played an essential role in this case, detecting the tumour and its extension, indicating a poor prognosis and guiding treatment.
authors.affiliation: Département de cardiologie, CHU de la Cavale-Blanche, Brest.
authors.forename: Y
authors.initials: Y
authors.lastname: Jobic
authors.forename: M C
authors.initials: MC
authors.lastname: Moal
authors.forename: J M
authors.initials: JM
authors.lastname: Larlet
authors.forename: F
authors.initials: F
authors.lastname: Verdun
authors.forename: C
authors.initials: C
authors.lastname: Mounayer
authors.forename: P
authors.initials: P
authors.lastname: Guillo
authors.forename: M
authors.initials: M
authors.lastname: Gilard
authors.forename: J J
authors.initials: JJ
authors.lastname: Blanc
authors.forename: B
authors.initials: B
authors.lastname: Bourbigot
authors.forename: T
authors.initials: T
authors.lastname: Boschat
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D018287:Carcinoma, Large Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D017548:Echocardiography, Transesophageal; D004617:Embolism / Q000209:etiology* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006338:Heart Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D007511:Ischemia / Q000209:etiology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011150:Popliteal Artery; D014057:Tomography, X-Ray Computed
vernacular_title: Embolie artérielle chez une greffée rénale. Découverte échocardiographique d'un cancer bronchique à extension intracardiaque.