Vitamin E and coenzyme Q concentrations in the thyroid tissues of patients with various thyroid disorders.
To clarify the different roles of free radical scavenging systems in various thyroid disorders, we measured the levels of alpha-, beta-, and gamma-tocopherols and coenzyme Q in the thyroid tissues of patients with thyroid tumors and Graves' disease using high-performance liquid chromatography. The levels of alpha-tocopherols and gamma-tocopherols in the thyroid tissue of patients with papillary carcinoma and the level of gamma-tocopherol in the thyroid tissue of patients with malignant lymphoma were elevated compared with those in normal thyroid tissues. The level of coenzyme Q was reduced in the thyroid tissue of patients with Graves' disease and follicular and papillary thyroid carcinomas. These findings imply that vitamin E and coenzyme Q as scavengers play some role in thyroid follicular cell hyperfunction or dysfunction.
Mano
T
T
Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Iwase
K
K
Hayashi
R
R
Hayakawa
N
N
Uchimura
K
K
Makino
M
M
Nagata
M
M
Sawai
Y
Y
Oda
N
N
Hamada
M
M
Aono
T
T
Nakai
A
A
Nagasaka
A
A
Itoh
M
M
D006111:Graves Disease / Q000378:metabolism*; D006801:Humans; D013961:Thyroid Gland / Q000737:chemistry*; D013964:Thyroid Neoplasms / Q000737:chemistry*; D014451:Ubiquinone / Q000032:analysis*; D014810:Vitamin E / Q000032:analysis*
D014451:Ubiquinone; D014810:Vitamin E