title: Wegener's granulomatosis in a patient with apparent drug-induced acute interstitial nephritis.
abstract: We describe a patient whose clinical presentation was suggestive of drug-induced acute interstitial nephritis (AIN). A renal biopsy and serologic testing led instead to the diagnosis of Wegener's granulomatosis (WG) with necrotizing crescentic glomerulonephritis. Treatment with corticosteroids and cyclophosphamide resulted initially in complete recovery of renal function, and an exacerbation of acute renal failure after doses of these agents had been tapered responded to resumption of the original regimen. We report this case to emphasize the potentially identical presentations of AIN and WG. Since the two conditions are treated differently, we suggest that the diagnosis of AIN should be accepted only after biopsy confirmation.
authors.affiliation: Samuel S. Stratton Department of Veterans Affairs Medical Center and Albany Medical College, New York 12208, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Haqqie
authors.forename: K R
authors.initials: KR
authors.lastname: Phelps
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: R E
authors.initials: RE
authors.lastname: Urizar
mesh_terms: D000208:Acute Disease; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005921:Glomerulonephritis / Q000150:complications; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D008854:Microscopy, Electron; D009395:Nephritis, Interstitial / Q000139:chemically induced*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone