title: Prognostic relevance of genetic alterations in the p32 region of chromosome 1 in neuroblastoma.
abstract: Thirty-six neuroblastomas were analysed for chromosome 1p alterations and their prognostic relevance. In 72% (26/36) of the patients, 1p alterations were identified in the tumours using 24 polymorphic loci ranging 1p22-1p36.3. LOH was identified in 25 children, and in 10 additional allelic imbalance was identified. In 1 child allelic imbalance was the sole alteration. Imbalance was termed as gain in intensity of one allele with or without reduction of the second allele (< 50%). The imbalance was identified in adjacent regions to the LOH. Two distinct regions of LOH were identified: 1p36.1-p36.3 and 1p31-p32. The common imbalance regions overlapped the common LOH regions. The children with LOH and imbalance had improved survival (100%) compared to the children with LOH only (26%) after 48 months of follow-up. The imbalance had an advantageous effect that is reflected by the improved outcome in children with other unfavourable clinical features.
authors.affiliation: Schneider Children's Medical Center of Israel, Rabin Medical Center, Petah Tikva, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Avigad
authors.forename: H
authors.initials: H
authors.lastname: Benyaminy
authors.forename: Y
authors.initials: Y
authors.lastname: Tamir
authors.forename: D
authors.initials: D
authors.lastname: Luria
authors.forename: I
authors.initials: I
authors.lastname: Yaniv
authors.forename: J
authors.initials: J
authors.lastname: Stein
authors.forename: B
authors.initials: B
authors.lastname: Stark
authors.forename: R
authors.initials: R
authors.lastname: Zaizov
mesh_terms: D000483:Alleles; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D006801:Humans; D007223:Infant; D019656:Loss of Heterozygosity / Q000235:genetics*; D009447:Neuroblastoma / Q000235:genetics*; D011379:Prognosis; D016019:Survival Analysis