Successful treatment of disseminated coccidioidomycosis with amphotericin B lipid complex.
Coccidioidomycosis is endemic in regions of the Americas, but this infection may be encountered in travellers who return from an endemic region. A case is reported of a disseminated infection in a Hong Kong Chinese man, who was successfully treated with amphotericin B lipid complex (ABLC) after intolerance and toxicity precluded the use of other antifungal agents. Lipid-based formulations of amphotericin B merit further evaluation in the treatment of coccidioidomycosis and other systemic mycoses.
Koehler
A P
AP
Department of Microbiology, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories.
Cheng
A F
AF
Chu
K C
KC
Chan
C H
CH
Ho
A S
AS
Lyon
D J
DJ
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D003047:Coccidioidomycosis / Q000188:drug therapy* / Q000635:transmission; D004338:Drug Combinations; D006801:Humans; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D010715:Phosphatidylglycerols / Q000627:therapeutic use*; D016896:Treatment Outcome
D000935:Antifungal Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D000666:Amphotericin B