The significance of urinary N-acetyl-beta-D-glucosaminidase for predicting early stage diabetic nephropathy.
We studied urinary N-acetyl-beta-D-glucosaminidase (NAG) in the early stage of diabetic nephropathy in 27 non-insulin-dependent diabetes mellitus (NIDDM) patients with a microalbumin level below 20 mg on 24-hour urine sample. Microalbumin and NAG excretion were measured in 24-hour urine samples collected on three separate occasions within seven days of admission. Creatinine clearance was determined simultaneously. There was a significant negative correlation between the creatinine clearance and 24-hour urinary NAG (r = -0.38, p < 0.05). Elevation of urinary NAG may indicate decreased renal function during early stage NIDDM nephropathy.
Kato
H
H
Department of Internal Medicine, Saga Medical School, Japan.
Takashima
T
T
Kishikawa
H
H
Emura
S
S
Ohmori
K
K
D000118:Acetylglucosaminidase / Q000652:urine*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000652:urine; D004796:Clinical Enzyme Tests; D003404:Creatinine / Q000097:blood; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
D015415:Biomarkers; D003404:Creatinine; D000118:Acetylglucosaminidase