Electrophysiologic assessment of calcium channel blockers in transplanted hearts: an experimental study.
The effects of calcium channel blockers on automaticity, conduction, and refractoriness were studied in a model of heterotopic heart transplantation in dogs, which combined an innervated heart (recipient) and a denervated one (donor). Following the surgical procedure, 0.2 mg/kg verapamil (n = 10), 0.15 mg/kg diltiazem (n = 10), or 5 microg/kg + 30 microg/kg/h nifedipine (n = 10) was administered intravenously. In basal situation and after drug administration, each heart was assessed for AV interval, cycle length, sinoatrial conduction time, atrioventricular node antegrade block point, and atrioventricular node and ventricular refractory periods; electrocardiographic PR and QT intervals and QRS complexes; systemic arterial, pulmonary artery, central venous, and pulmonary capillary wedge pressures; and cardiac output. The depressor effects of these calcium channel blockers on automaticity, refractoriness, and conduction were more intense in the transplanted hearts, very possibly because of the absence of adrenergic reflexes mediated by the autonomic nervous system; in particular, verapamil produced a great depression of sinus automaticity in a large number of cases.
Alvarez
L
L
Department of Experimental Surgery, Clínica Puerta de Hierro, Madrid, Spain.
Escudero
C
C
Torralba
A
A
Millán
I
I
D000818:Animals; D001283:Atrioventricular Node / Q000187:drug effects / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000633:toxicity; D004110:Diltiazem / Q000494:pharmacology* / Q000633:toxicity; D004285:Dogs; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000294:innervation / Q000503:physiopathology; D016027:Heart Transplantation; D006439:Hemodynamics / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology* / Q000633:toxicity; D012849:Sinoatrial Node / Q000187:drug effects / Q000503:physiopathology; D016042:Transplantation, Heterotopic; D016276:Ventricular Function / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology* / Q000633:toxicity
D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine