T-cell lymphoma caused by herpesvirus saimiri C488 independently of ie14/vsag, a viral gene with superantigen homology.
The immediate-early gene ie14/vsag of herpesvirus saimiri has homology with murine superantigens. We compared the pathogenesis of infection with either ie14/vsag deletion mutants or wild-type virus C488 in cottontop tamarin monkeys (Saguinus oedipus). Two weeks after infection, all animals developed acute T-cell lymphomas independently of the presence of the viral ie14/vsag gene.
Knappe
A
A
Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Thurau
M
M
Niphuis
H
H
Hiller
C
C
Wittmann
S
S
Kuhn
E M
EM
Rosenwirth
B
B
Fleckenstein
B
B
Heeney
J
J
Fickenscher
H
H
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000502:physiology*; D017353:Gene Deletion; D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000473:pathology / Q000821:virology*; D006567:Herpesvirus 2, Saimiriine / Q000235:genetics / Q000502:physiology*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000821:virology*; D012452:Saguinus; D018089:Superantigens / Q000235:genetics / Q000502:physiology*; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology*
D000956:Antigens, Viral; D018089:Superantigens