Retinoids and metastatic renal cell carcinoma.
The treatment of metastatic renal cell carcinoma remains unsatisfactory. Several therapeutic trials with retinoids and r interferon alpha (r IFN alpha) suggest a synergic antiproliferative effect between retinoid acid and r IFN alpha. Pharmacokinetic data and the mechanism of antiproliferative effects of retinoids are discussed. The induction of growth arrest is related to the expression of specific retinoid receptors. Further investigations are required in order to target the patient population which requires this therapy.
Paule
B
B
Service de Rhumatologie, Centre Hospitalier de Bicêtre, Le Kremlin-Bicêtre.
Brion
N
N
D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D011994:Recombinant Proteins; D012176:Retinoids / Q000494:pharmacology / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D007370:Interferon Type I; D011994:Recombinant Proteins; D012176:Retinoids