Expression of Ret/PTC1, -2, -3, -delta3 and -4 in German papillary thyroid carcinoma.
Ret/PTC oncogene has been described with a frequency of 2.5-30% in papillary thyroid carcinomas. We examined the expression of ret/PTC in 99 German papillary thyroid carcinomas, including two recently described new variants of ret/PTC3 and identified eight ret/PTC-positive tumours (8%) but none with the new variants.
Mayr
B
B
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Germany.
Pötter
E
E
Goretzki
P
P
Rüschoff
J
J
Dietmaier
W
W
Hoang-Vu
C
C
Dralle
H
H
Brabant
G
G
D019677:Artificial Gene Fusion; D002291:Carcinoma, Papillary / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins; D005858:Germany; D006801:Humans; D056918:Nuclear Receptor Coactivators; D015513:Oncogene Proteins / Q000096:biosynthesis*; D015514:Oncogene Proteins, Fusion; D009857:Oncogenes; D016133:Polymerase Chain Reaction; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D051096:Proto-Oncogene Proteins c-ret; D011519:Proto-Oncogenes; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis*; D017384:Sequence Deletion; D013964:Thyroid Neoplasms / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors
D029721:Drosophila Proteins; C111382:NCOA4 protein, human; D056918:Nuclear Receptor Coactivators; D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila; C093573:ret-PTC fusion oncoproteins, human