[The effect of substance P on collagen concentration in rat colon].
Anastomotic leakage is the main reason of high mortality in colorectal surgery. The healing of anastomosis is predominantly derived from collagen fibrils. Substance P causes the proliferation of fibroblasts and connective tissue. The effect of SP on postoperative changes of collagen concentration was measured around the anastomotic side in rats. The studies shows, that SP induces a significant decrease in collagen synthesis in colon.
Gryszkiewicz
M
M
I Kliniki Chirurgicznej Akademii Medycznej w Lodzi.
D000714:Anastomosis, Surgical / Q000009:adverse effects; D000818:Animals; D003094:Collagen / Q000096:biosynthesis / Q000187:drug effects*; D003106:Colon / Q000187:drug effects* / Q000378:metabolism / Q000601:surgery; D003107:Colorectal Surgery / Q000379:methods; D006801:Humans; D008297:Male; D011182:Postoperative Care; D051381:Rats; D017208:Rats, Wistar; D013373:Substance P / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D013373:Substance P; D003094:Collagen
Wpływ substancji P na zawartość kolagenu w jelicie grubym szczura.