title: Lessons from TGF-beta transgenic mice.
abstract: Aberrant expression of TGF-beta and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-beta isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased activity of TGF-beta in the intact organism. We will review the pertinent features of some of these models, and discuss new insights provided by these studies into regulation and role of TGF-beta in health and disease.
authors.affiliation: Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY 10461-1602, USA. bottinge@aecom.yu.edu
authors.forename: E P
authors.initials: EP
authors.lastname: Böttinger
authors.forename: J B
authors.initials: JB
authors.lastname: Kopp
mesh_terms: D000818:Animals; D004194:Disease; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D016296:Mutagenesis; D018125:Receptors, Transforming Growth Factor beta / Q000502:physiology; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000235:genetics* / Q000502:physiology*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta