Late-onset Leber's hereditary optic neuropathy.
Progressive, sequential visual loss in the left and then right eye was reported in a 73-year-old male over three months. The presence of a family history of visual loss and the lack of other findings in association with bilateral cecocentral scotomata led to a diagnosis of new onset Leber's hereditary optic neuropathy, confirmed by the presence of a mutation at the 11,778 position. This case illustrates that Leber's hereditary optic neuropathy may manifest late in life.
Ajax
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Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
Kardon
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D000368:Aged; D004252:DNA Mutational Analysis; D006801:Humans; D008297:Male; D015418:Optic Atrophies, Hereditary / Q000175:diagnosis* / Q000235:genetics; D017354:Point Mutation; D014786:Vision Disorders / Q000175:diagnosis / Q000235:genetics; D014792:Visual Acuity; D014794:Visual Fields