title: [Alterations of hemostasis in liver cirrhosis of the dog].
abstract: In seven dogs with histologically proven liver cirrhosis the activity of the single coagulation factors with the exception of factor VIII:C, of the inhibitors antithrombin III and protein C as well as plasminogen and alpha 2-antiplasmin was distinctly lower than in the control group (p < 0.0001). The changes of the factors VII [median (x0.50) = 17 %] and X (x0.50 = 18 %) as well as of protein C (x0.50 = 15 %) were particularly pronounced. Diminution of activity certainly exceeded also in nearly all of the remaining haemostatic proteins the decrease of albumin concentration. Besides the shorter half life time, this reflected an increased consumption in consequence of intravascular coagulations and fibrinolysis. The latter could also be seen from the significantly increased concentrations of soluble fibrin and fibrin(ogen) degradation products. Therefore, the alterations of the haemostatic system measured in dogs in many details were in accordance with findings in human beings suffering from liver cirrhosis.
authors.affiliation: Klinik für kleine Haustiere der Tierärztlichen Hochschule Hannover.
authors.forename: R
authors.initials: R
authors.lastname: Mischke
authors.forename: D
authors.initials: D
authors.lastname: Pöhle
authors.forename: H A
authors.initials: HA
authors.lastname: Schoon
authors.forename: M
authors.initials: M
authors.lastname: Fehr
authors.forename: I
authors.initials: I
authors.lastname: Nolte
mesh_terms: D000818:Animals; D001779:Blood Coagulation Factors / Q000032:analysis*; D004283:Dog Diseases; D004285:Dogs; D005337:Fibrin / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000662:veterinary*; D012016:Reference Values
chemical_list: D001779:Blood Coagulation Factors; D005337:Fibrin; D005340:Fibrinogen
vernacular_title: Veränderungen der Hämostase bei der Leberzirrhose des Hundes.