title: Net hepatic glucose output is normal on postoperative day 1 after liver transplantation.
abstract: The liver plays a central role in carbohydrate metabolism and glucose homeostasis; therefore, the rapid recovery of glucose homeostasis after liver transplantation (LT) is important. The purpose of this study was to evaluate hepatic and whole-body glucose production (WBGP) on postoperative day 1 after LT using a combination of arteriovenous differences and radioisotope techniques. Two groups of female commercially bred pigs with an average body weight of 31.9 +/- 1.4 kg were studied. A control group (n = 6) underwent laparotomy. A transplanted group (n = 6) was submitted to LT. All pigs were instrumented with catheters placed in the carotid artery and the hepatic, portal, and jugular vein, and flow probes were placed around the hepatic artery and portal vein. WBGP was measured by a primed constant infusion of 3-[3H]glucose 1 day postoperatively. Plasma glucose was 89 +/- 6 versus 98 +/- 7 mg/dL in the control and transplanted groups, respectively. WBGP was increased by 42 per cent in the transplanted group (2.54 +/- 0.17 vs 3.62 +/- 0.39 mg/kg.min), but the net hepatic glucose output was not different between the control and the transplanted groups (1.53 +/- 0.28 vs 1.68 +/- 0.31 mg/kg.min). These results demonstrate that net hepatic glucose output was not different between the control and transplanted pigs, suggesting that LT does not compromise the ability of the liver to produce glucose. However, the WBGP was increased by 42 per cent in the transplanted group, suggesting either a significant contribution from another organ or a significant intrahepatic utilization of glucose.
authors.affiliation: Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN 37232-4753, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Bradley
authors.forename: M
authors.initials: M
authors.lastname: Sika
authors.forename: Y T
authors.initials: YT
authors.lastname: Becker
authors.forename: K T
authors.initials: KT
authors.lastname: Blair
authors.forename: K
authors.initials: K
authors.lastname: Jabbour
authors.forename: P E
authors.initials: PE
authors.lastname: Williams
authors.forename: J
authors.initials: J
authors.lastname: Phillips
authors.forename: W C
authors.initials: WC
authors.lastname: Chapman
authors.forename: J K
authors.initials: JK
authors.lastname: Wright
authors.forename: P J
authors.initials: PJ
authors.lastname: Flakoll
authors.forename: C W
authors.initials: CW
authors.lastname: Pinson
mesh_terms: D000818:Animals; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D008099:Liver / Q000378:metabolism*; D016031:Liver Transplantation / Q000502:physiology*; D011184:Postoperative Period; D013552:Swine; D013997:Time Factors
chemical_list: D005947:Glucose