Abnormal cholesterol biosynthesis produced by AY 9944 in the rat leads to skeletal deformities similar to the Smith-Lemli-Opitz syndrome.
Batta
A K
AK
Salen
G
G
D000014:Abnormalities, Drug-Induced; D000818:Animals; D000924:Anticholesteremic Agents / Q000633:toxicity*; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000002:abnormalities*; D002784:Cholesterol / Q000096:biosynthesis*; D004791:Enzyme Inhibitors / Q000633:toxicity; D005260:Female; D016142:Holoprosencephaly / Q000139:chemically induced; D006801:Humans; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011247:Pregnancy; D051381:Rats; D019082:Smith-Lemli-Opitz Syndrome / Q000209:etiology / Q000378:metabolism*; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride / Q000633:toxicity*
D000924:Anticholesteremic Agents; D004791:Enzyme Inhibitors; D001371:trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; D002784:Cholesterol; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; C019995:7-dehydrocholesterol reductase