Induction of onion-induced haemolytic anaemia in dogs with sodium n-propylthiosulphate.
The haemolytic effect of sodium n-propylthiosulphate, which had been isolated from boiled onions, was studied to determine whether it could be one of the agents responsible for induced haemolytic anaemia in dogs. The oral administration of 500 mumol/kg bodyweight of the compound to dogs resulted in a haemolytic anaemia associated with an increase of Heinz body formation in erythrocytes, which was more severe in dogs with the hereditary condition which results in erythrocytes with high concentrations of reduced glutathione and potassium than in normal dogs. In the affected dogs there was a 10-fold increase in the concentration of oxidised glutathione in their erythrocytes 12 hours after the administration of the compound, whereas in normal dogs there was almost no change.
Yamato
O
O
Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Hayashi
M
M
Yamasaki
M
M
Maede
Y
Y
D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000209:etiology / Q000503:physiopathology*; D004285:Dogs; D004912:Erythrocytes / Q000187:drug effects; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism*; D006366:Heinz Bodies / Q000187:drug effects; D019697:Onions / Q000737:chemistry*; D013885:Thiosulfates / Q000008:administration & dosage* / Q000737:chemistry
D013885:Thiosulfates; D005978:Glutathione