Antifungal and larvicidal meroterpenoid naphthoquinones and a naphthoxirene from the roots of Cordia linnaei.
Three new meroterpenoid naphthoquinones, the known cordiaquinone B and a new naphthoxirene have been isolated from the roots of Cordia linnaei. Their structures were established by spectrometric methods including EI, D/CI and FAB mass spectrometry, 1H, 13C and 2D NMR experiments. The naphthoquinones showed activity against Cladosporium cucumerinum, Candida albicans and the larvae of the yellow fever-transmitting mosquito Aedes aegypti, while the naphthoxirene derivative was found to be inactive in the same bioassays.
Ioset
J R
JR
Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, Lausanne, Switzerland.
Marston
A
A
Gupta
M P
MP
Hostettmann
K
K
D000330:Aedes / Q000187:drug effects*; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002963:Cladosporium / Q000187:drug effects; D004852:Epoxy Compounds / Q000737:chemistry* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
D000935:Antifungal Agents; D004852:Epoxy Compounds; D009285:Naphthoquinones; D010936:Plant Extracts; D013729:Terpenes; C111672:naphthoxirene