Mechanism of citrinin-induced dysfunction of mitochondria. VI. Effect on iron-induced lipid peroxidation of rat liver mitochondria and microsomes.
The inhibition by citrinin (CTN) of lipid peroxidation of mitochondria, sub-mitochondrial particles (SMP) and microsomes was studied. This effect was reversed by the presence of high concentrations of Fe3+ (0.4 and 0.5 mM), suggesting chelation of the mycotoxin with iron or interference in the reduction of Fe3+.
Ribeiro
S M
SM
Departamento de Bioquimica da Universidade Federal do Paraná, Brasil.
Campello
A P
AP
Chagas
G M
GM
Klüppel
M L
ML
D000818:Animals; D002712:Chlorides; D002953:Citrinin / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D005290:Ferric Compounds / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008862:Microsomes, Liver / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D002712:Chlorides; D005290:Ferric Compounds; D002953:Citrinin; D008315:Malondialdehyde; D007501:Iron; C024555:ferric chloride