title: A mathematical model for the determination of the optimum value of the treatment threshold for a continuous risk factor.
abstract: Hypercholesterolemia or hypertension are continuous risk factors for coronary heart disease. When a preventive action is carried out against such a risk factor, it is necessary to specify a risk factor level value, named the treatment threshold, above which a subject should be treated. But a non-arbitrary determination of this threshold value is impossible from the epidemiological data. A method for the non-arbitrary determination of the treatment threshold value is presented, based upon mathematical modelling of the clinical and economics consequences of the prevention policy in the whole population. In a cost-effectiveness approach, the model was used to estimate the cost per coronary event prevented according to the threshold value for blood cholesterol. It was found that a minimum in this outcome proposed as the optimum treatment threshold. It is possible, from a public health point of view, to determine an optimum, non-arbitrary treatment threshold value in the prevention of coronary heart disease with cholesterol-lowering interventions. The model proposed here could be useful in decision making processes.
authors.affiliation: Université Claude Bernard Lyon, Hospices Civils de Lyon, France. MCU@upcl.univ-lyon1.fr
authors.forename: M
authors.initials: M
authors.lastname: Cucherat
authors.forename: J P
authors.initials: JP
authors.lastname: Boissel
mesh_terms: D000924:Anticholesteremic Agents / Q000191:economics* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000191:economics* / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D005602:France; D006291:Health Policy; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000191:economics*; D006973:Hypertension / Q000188:drug therapy / Q000191:economics*; D018803:Models, Economic
chemical_list: D000924:Anticholesteremic Agents; D000959:Antihypertensive Agents