Effect of particle size and coating level on the diffuse reflectance of wax matrices.
The aim of this study was to examine the influence of particle size and extent of coating on the diffuse-reflectance spectra of wax matrices containing embedded potassium chloride. Near-infrared spectroscopy was used to analyse the diffuse-reflectance characteristics of the prepared multi-particulate matrices without destructive sample preparation. A 2-factor, 3-level face-centred central composite design was selected to construct a second-order polynomial model which described the effect of particle size and amount of coating on the intensity of the diffusely reflected light. A non-linear model was used to demonstrate the effect of the selected parameters on the intensity of the reflected light; good correlation was obtained between experimental and predicted results. The results indicated that the extent of coating and the particle size of the examined systems in the selected particle size-range modified the intensity of the reflected light. It can be concluded that near-infrared spectroscopy is a sensitive means of measuring not only the particle size of powders (substrates and their mixtures), but also that of coated multi-particulate systems.
Dredán
J
J
Pharmaceutical Institute, Semmelweis University of Medicine, Budapest, Hungary.
Zelkó
R
R
Antal
I
I
Bihari
E
E
Rácz
I
I
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000737:chemistry*; D007700:Kinetics; D010316:Particle Size; D011189:Potassium Chloride / Q000737:chemistry; D011208:Powders; D019265:Spectroscopy, Near-Infrared; D014885:Waxes / Q000737:chemistry*
D003692:Delayed-Action Preparations; D011208:Powders; D014885:Waxes; D011189:Potassium Chloride