title: Preoperative antimicrobial prophylaxis with a long-acting cephalosporin for thoracic surgery in 192 non small cell lung cancer patients.
abstract: The efficacy of preoperative antibiotic prophylaxis in thoracic surgery with a single dose of ceftriaxone was investigated. Here we report the results of a prospective study including 192 patients undergoing thoracic surgery for non small cell lung cancer. Overall, the postoperative infection rate, as measured by wound, respiratory tract, and urinary tract infections, was 8.3% (16/192). Ceftriaxone was well tolerated, and no allergic or other adverse reactions were reported. A single preoperative dose of ceftriaxone was cost-effective and allowed considerable saving of time, material, labor costs and money. This study, even though open and non-comparative, suggests that the routine use of a single preoperative dose of ceftriaxone provides a cost-effective prophylaxis for patients undergoing major thoracic operations.
authors.affiliation: Department of Thoracic Surgery, University of Federico II, Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Elia
authors.forename: M
authors.initials: M
authors.lastname: Gentile
authors.forename: G
authors.initials: G
authors.lastname: Guggino
authors.forename: G R
authors.initials: GR
authors.lastname: Marcone
authors.forename: A
authors.initials: A
authors.lastname: Ferraro
authors.forename: G
authors.initials: G
authors.lastname: Ferrante
mesh_terms: D000328:Adult; D000368:Aged; D019072:Antibiotic Prophylaxis / Q000191:economics; D002289:Carcinoma, Non-Small-Cell Lung / Q000601:surgery*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control*; D011446:Prospective Studies; D013510:Pulmonary Surgical Procedures; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*; D014552:Urinary Tract Infections / Q000517:prevention & control
chemical_list: D002511:Cephalosporins; D002443:Ceftriaxone