Excitotoxic lesions of the subthalamic nucleus ameliorate asymmetry induced by striatal dopamine depletion in the rat.
We investigated the effect of unilateral dorsal striatal dopamine depletion (by intrastriatal infusion of 6-OHDA), ibotenic acid lesions of the subthalamic nucleus (STN) and combined dopamine depletion and STN lesions on sensorimotor asymmetry using a test of somatosensory asymmetry [T. Schallert et al., Pharmacol. Biochem. Behav. 16 (1982) 455-462]. The unilateral striatal dopamine depletion resulted in a somatosensory asymmetry. This asymmetry was ameliorated in the rats with combined dopamine depletion and STN lesion. indicating the potential beneficial nature of STN inactivation in rats with striatal dopamine depletion.
Phillips
J M
JM
School of Psychology, University of St. Andrews, Scotland, UK. jmp2@st-and.ac.uk
Latimer
M P
MP
Gupta
S
S
Winn
P
P
Brown
V J
VJ
D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity*; D007839:Functional Laterality / Q000187:drug effects; D006651:Histocytochemistry; D007051:Ibotenic Acid / Q000633:toxicity*; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D016627:Oxidopamine / Q000633:toxicity*; D051381:Rats; D013565:Sympatholytics / Q000633:toxicity*; D013787:Thalamic Nuclei / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D018690:Excitatory Amino Acid Agonists; D013565:Sympatholytics; D007051:Ibotenic Acid; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine