Intrathecal administration of the adenosine A1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain.
Effects of intrathecally (i.t.) administered R-phenylisopropyl adenosine (R-PIA), an adenosine A1 receptor agonist, on presumed pain behaviour were assessed in a rat model of chronic central pain. Spinal cord injury was induced photochemically via laser irradiation of the spinal cord after intravenous injection of erythrosin B in rats. The chronic allodynia-like behaviour that developed in some animals was studied. R-PIA (3 and 10 nmol), injected i.t. reduced the mechanical and cold allodynia-like symptoms as tested with von Frey filaments and ethyl-chloride spray, respectively. No side effects were observed. The effect of R-PIA was significant for up to 5 h and was reversed by theophylline, an adenosine receptor antagonist.
Sjölund
K F
KF
Department of Anesthesiology and Intensive Care, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
von Heijne
M
M
Hao
J X
JX
Xu
X J
XJ
Sollevi
A
A
Wiesenfeld-Hallin
Z
Z
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003080:Cold Temperature; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007278:Injections, Spinal; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology*; D010812:Physical Stimulation; D058906:Purinergic P1 Receptor Agonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000502:physiology; D013119:Spinal Cord Injuries / Q000503:physiopathology; D014665:Vasodilator Agents / Q000494:pharmacology*
D058906:Purinergic P1 Receptor Agonists; D014665:Vasodilator Agents; C047235:N-(1-methyl-2-phenylethyl)adenosine; D000241:Adenosine