title: Phaeohyphomycotic ulcer caused by Phialophora verrucosa: successful treatment with itraconazole.
abstract: We report the first well documented case of subcutaneous phaeohyphomycotic infection caused by Phialophora verrucosa in India. Examination of the biopsied tissue from an ulcerating lesion on the shin of the left leg of a 45-year-old woman from Bombay, India, showed numerous dematiaceous, septate, branching hyphal elements and thick-walled cells characteristic of phaeohyphomycosis. Cultures of the scrapings from the lesion and of the biopsied tissue yielded a pigmented fungus that was identified as P. verrucosa. Initial treatment with fluconazole followed by oral itraconazole for 30 days and local application of a copper sulphate solution resulted in complete resolution of the lesion. Treatment with itraconazole was continued for an additional 3 months after complete healing. No new lesions developed and the patient did not show jaundice, hepatosplenomegaly or any other signs of toxicity.
authors.affiliation: Department of Microbiology, L.T.M. Medical College and Hospital, Sion, Bombay, India.
authors.forename: U M
authors.initials: UM
authors.lastname: Tendolkar
authors.forename: P
authors.initials: P
authors.lastname: Kerkar
authors.forename: H
authors.initials: H
authors.lastname: Jerajani
authors.forename: A
authors.initials: A
authors.lastname: Gogate
authors.forename: A A
authors.initials: AA
authors.lastname: Padhye
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D007871:Leg Ulcer / Q000188:drug therapy* / Q000382:microbiology; D008875:Middle Aged; D010676:Phialophora / Q000166:cytology / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole