The pH dependence of silicon-iron interaction in rats.
A 2 x 2 x 3 factorial experiment was conducted to study the pH dependence of a silicon-iron interaction in vivo. The dietary treatments used in the factorial design were the following (mg/kg of diet): silicon, 0 and 500; iron, 35 and 187; acid-base, ammonium chloride as 0.5% of total diet (acidic), sodium bicarbonate as 1.0% of total diet (basic), or no supplementation of acid or base (control). The supplementation of 500 mg silicon/kg of diet increased plasma-iron concentration in rats fed the acidic or control diets, but not in rats fed the basic diet. A high dietary-iron level suppressed copper absorption and utilization and subsequently imposed a negative effect on its own utilization. An increase in the plasma total-cholesterol concentration caused by high dietary-iron level was likely a consequence of the antagonistic effect of iron on copper absorption and utilization. The use of cupric sulfate pentahydrate as the dietary-copper source in this study resulted in plasma copper concentrations that were approximately twice those obtained in a related study using cupric carbonate. Also, a 42% coefficient of variation (C.V.) for plasma-copper concentrations of rats fed cupric sulfate in this study was greatly reduced from the C.V. = 108% previously associated with the dietary cupric carbonate.
Jia
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Department of Chemistry and Biochemistry, South Dakota State University, Brookings 57007, USA.
Emerick
R J
RJ
Kayongo-Male
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H
D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000097:blood / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012825:Silicon / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D003300:Copper; D007501:Iron; D002570:Ceruloplasmin; D015032:Zinc; D012825:Silicon