title: SERF: a program for accessible surface area calculations.
abstract: The program SERF has been designed to facilitate the greater use of accessible surface area calculations in the analysis of protein structure, including analysis of surface area changes on binding and complexation. For comparative purposes, the program implements a number of alternative methods for calculating surface areas, including those that approximate residues by single spheres. Algorithmic details, comparative performance, and the software implementation of SERF are discussed.
authors.affiliation: Department of Physical and Metabolic Sciences, Astra Charnwood, Loughborough, Leicestershire, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: Flower
mesh_terms: D000465:Algorithms; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry*; D012984:Software
chemical_list: D011506:Proteins