Alkamides from Phyllanthus fraternus.
Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an alpha, beta, gamma, delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.
Sittie
A A
AA
Lemmich
E
E
Olsen
C E
CE
Hviid
L
L
Brøgger Christensen
S
S
D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D018320:Leishmania major / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects
D000577:Amides; D000981:Antiprotozoal Agents