Is there a correlation between scores of nociceptive behavioral responses to formalin injections given at different body sites in the rat?
Correlations between behavioural nociceptive responses to an injection of formalin solution in the hindpaw and upper lip were sought in 28 male rats divided into two groups. One group received a first injection in the hindpaw and 7 days later, a second one in the lip (paw-lip group). The injection order was reversed in the second group (lip-paw group). After each injection, the duration of lip rubbing for the orofacial formalin test, the duration of paw licking and the number of paw flinchings for the hindpaw test were measured. The Spearman test revealed no correlation between lip rubbing and paw flinching in either group but a significant correlation between lip rubbing and paw licking occurred in both groups.
Cadet
R
R
Université d'Auvergne, Laboratoire de Physiologie Oro-Faciale, Faculté de Chirurgie Dentaire, Clermont-Ferrand, France.
Pajot
J
J
Papon
A
A
Woda
A
A
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D005121:Extremities; D005557:Formaldehyde; D007279:Injections, Subcutaneous; D008046:Lip; D008297:Male; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley
D005557:Formaldehyde