Effects of human recombinant growth hormone (rhGH) on inflammatory responses in patients undergoing abdominal aortic aneurysm repair.
BACKGROUND
Human recombinant growth hormone (rhGH) has been shown to increase skeletal muscle protein synthesis and improve nitrogen balance in critically ill patients and those undergoing surgery. rhGH effects on hepatic protein turnover in critically ill patients are less clearly understood.


OBJECTIVE
To examine rhGH effects on hepatic acute phase protein responses and inflammatory cytokine release in patients undergoing major surgery.


METHODS
Prospective double blind randomised trial.


METHODS
Tertiary referral university teaching hospital.


METHODS
Patients undergoing elective abdominal aortic aneurysm repair.


METHODS
Patients received rhGH (Genotropin, 0.3 IU/kg per day, n = 8) or placebo (n = 10) for 6 days prior to surgery.


RESULTS
Blood levels of growth hormone (GH) and insulin-like growth factor (IGF-1) were measured following rhGH treatment and C-reactive protein (CRP), serum amyloid A (SAA) and the cytokines interleukin-6 (IL-6) and the IL-1 receptor antagonist (IL-1ra) were measured for up to 24 h following surgery. Significant increases in plasma rhGH (0.84 +/- 0.3, mean (sem) versus 52 +/- 20 mU/l, p < 0.0008) and IGF-1 levels (119 +/- 13 versus 644 +/- 110 ng/ml, p < 0.0001) were seen prior to surgery following rhGH administration. No differences in acute phase protein or cytokine levels were seen following surgery in patients receiving rhGH.


CONCLUSIONS
These results indicate that pre-operative administration of rhGH does not alter acute phase protein or inflammatory cytokine release in response to major surgery.
Mealy
K
K
Department of Surgery, St. James's Hospital, Dublin, Ireland. k.mealy@serv0.ed.ac.uk
Barry
M
M
O'Mahony
L
L
Sheehan
S
S
Burke
P
P
McCormack
C
C
Whitehead
A S
AS
Bouchier-Hayes
D
D
D000368:Aged; D000784:Aortic Dissection / Q000097:blood* / Q000601:surgery*; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000601:surgery*; D001053:Apolipoproteins / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D016638:Critical Illness; D004311:Double-Blind Method; D005260:Female; D019382:Human Growth Hormone / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D011446:Prospective Studies; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D011994:Recombinant Proteins / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000378:metabolism
D001053:Apolipoproteins; D015850:Interleukin-6; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins; D012709:Serum Albumin; D000685:Serum Amyloid A Protein; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D002097:C-Reactive Protein