title: Growth rate-dependent accumulation of RNA from plasmid-borne rRNA operons in Escherichia coli.
abstract: Inadequate regulation of the expression of additional plasmid-borne rRNA operons in Escherichia coli was exaggerated at slow growth rates, resulting in increases of approximately 100% for RNA concentration and 33% for doubling time. These observations are consistent with the hypothesis that multiple rRNA operons constitute a metabolic burden at slow growth rates.
authors.affiliation: Department of Microbiology and Center for Microbial Ecology, Michigan State University, East Lansing 48824-1101, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: Stevenson
authors.forename: T M
authors.initials: TM
authors.lastname: Schmidt
mesh_terms: D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development; D009876:Operon; D010957:Plasmids; D012329:RNA, Bacterial / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000235:genetics*; D014169:Transformation, Bacterial
chemical_list: D012329:RNA, Bacterial; D012335:RNA, Ribosomal