title: Effects of preparations of Chinese medicinal prescriptions on digestive enzymes in vitro and in vivo.
abstract: The effects of preparations of Chinese medicinal prescriptions on the activities of digestive enzymes were investigated. The starch dextrinizing activity of pancreatin was inhibited by Keishi-bukuryo-gan, Sho-seiryu-to, Hachimi-jio-gan, Unsei-in and Keishi-ka-shakuyaku-to to below 40% of the control activity. Hachimi-jio-gan and Sho-seiryu-to, in particular, lowered the activity to 4% and 24% of the control activity, respectively. The protein digestive activity of pancreatin was lowered by Keishi-bukuryo-gan, Oren-gedoku-to, Ryutan-shakan-to, Tokaku-joki-to, Yokuinin-to and Hange-shashin-to, to 56 to 70% of the control activity. To investigate the effects of the preparations of Chinese medicinal prescriptions on digestive enzymes in vivo, 600 mg (185 kBq) of 125I-egg white albumin were administered orally to rats 30 min before the administration of 100 mg of Tokaku-joki-to or Oren-gedoku-to. The radioactivity which transferred to the blood was less in the animals pre-fed these prescriptions than in the control animals, indicating that the digestion of egg white albumin was delayed in the presence of the prescriptions.
authors.affiliation: Osaka Prefectural Institute of Public Health, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamasaki
authors.forename: K
authors.initials: K
authors.lastname: Kajimura
authors.forename: M
authors.initials: M
authors.lastname: Nakano
authors.forename: H
authors.initials: H
authors.lastname: Yokoyama
authors.forename: K
authors.initials: K
authors.lastname: Yoneda
authors.forename: C
authors.initials: C
authors.lastname: Umezawa
mesh_terms: D000418:Albumins / Q000378:metabolism; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D004064:Digestive System / Q000187:drug effects* / Q000201:enzymology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D007457:Iodine Radioisotopes; D007700:Kinetics; D008297:Male; D010194:Pancreatin / Q000378:metabolism*; D010434:Pepsin A / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000418:Albumins; D004365:Drugs, Chinese Herbal; D007457:Iodine Radioisotopes; D010194:Pancreatin; D000681:Amylases; D010434:Pepsin A