Near haploidy in breast cancer: a particular pathway of chromosome evolution.
In a series of 260 cytologically abnormal breast cancers studied in our laboratory, we observed a single case of near-haploid karyotype: 27,X, +der(1;16)(q10;p10), +7, +14, +15. A review of published cases of near-haploid malignancies suggests that near haploidy belongs to a process of chromosome evolution distinct from that of most epithelial cancers in which hypodiploidy is strongly associated with the occurrence of unbalanced structural rearrangements. In near-haploid tumors, chromosome loss is independent from chromosome rearrangements and may not be associated with an adverse prognosis.
Flagiello
D
D
UMR 147 CNRS-Institut Curie, Paris, France.
Gerbault-Seureau
M
M
Padoy
E
E
Dutrillaux
B
B
D000782:Aneuploidy; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D014178:Translocation, Genetic