title: Effect of oxatomide on experimental allergic rhinitis in guinea pigs.
abstract: We have investigated the effect of oxatomide, an antiallergic agent, on experimental allergic rhinitis in sensitized guinea pigs. Oxatomide (1 and 10 mg/kg, p.o.) significantly inhibited the sneeze response and nasal rubbing after antigen challenge. Oxatomide (10 and 30 mg/kg) reduced the increase in nasal vascular permeability induced by the antigen-antibody reaction. The decreases in nasal cavity volume caused by nasal mucosal swelling 10 min, 30 min and 6 hr after antigen challenge were significantly inhibited by oxatomide (30 mg/kg). These results indicate that oxatomide inhibits the experimental allergic rhinitis in guinea pigs.
authors.affiliation: Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kaise
authors.forename: Y
authors.initials: Y
authors.lastname: Akamatsu
authors.forename: K
authors.initials: K
authors.lastname: Ohmori
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects; D006168:Guinea Pigs; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D012912:Sneezing / Q000187:drug effects
chemical_list: D018926:Anti-Allergic Agents; D010879:Piperazines; C015408:oxatomide