title: Cost and benefit in the choice of ECT schedule. Twice versus three times weekly ECT.
abstract: BACKGROUND
  We compared the antidepressant and cognitive effects of up to eight sessions of bilateral, brief pulse electroconvulsive therapy (ECT) administered twice (ECT x 2) or three times weekly (ECT x 3), to confirm that ECT x 3 acts more rapidly although the two schedules are equivalent in antidepressant outcome, and to establish whether ECT x 3 is indeed associated with more severe memory impairment.
  
  
  METHODS
  Patients with major depression, endogenous subtype were randomly assigned to ECT x 3 or ECT x 2 plus one simulated ECT per week, both up to a maximum of eight real ECT. Depression was evaluated by the Hamilton Depression Scale the day after each treatment and cognitive function by a test battery administered before and after the ECT series and at one month follow-up.
  
  
  RESULTS
  Assessed categorically or parametrically, there was no significant difference in antidepressant outcome between the two schedules. Rate of response was significantly more rapid with ECT x 3 but was associated with more severe memory impairment.
  
  
  CONCLUSIONS
  Twice weekly administration is an optimum schedule for bilateral ECT unless clinical indications require the more rapid antidepressant effect of three times weekly treatment.
authors.affiliation: Depression Treatment Unit, Herzog Hospital, Jerusalem, Israel.
authors.forename: B
authors.initials: B
authors.lastname: Shapira
authors.forename: N
authors.initials: N
authors.lastname: Tubi
authors.forename: H
authors.initials: H
authors.lastname: Drexler
authors.forename: D
authors.initials: D
authors.lastname: Lidsky
authors.forename: A
authors.initials: A
authors.lastname: Calev
authors.forename: B
authors.initials: B
authors.lastname: Lerer
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000191:economics / Q000628:therapy*; D003362:Cost-Benefit Analysis; D003657:Decision Making; D003866:Depressive Disorder / Q000191:economics / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000191:economics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged