title: Alpha adrenoceptors in the rabbit ear thermoregulatory microcirculation.
abstract: The rabbit ear microcirculation was analyzed in a chronic unanesthetized model to evaluate alpha adrenergic microvascular control in a thermoregulatory end organ. This model allowed direct measurement of microcirculatory responses without the effects of anesthetics or inflammatory responses induced by acute surgical intervention. The ipsilateral facial artery was catheterized for drug injections into the experimental ear. Microvascular diameter changes following stimulation or blockade of adrenoceptor (AR) subtypes were observed directly through a chronic microvascular chamber implanted in the rabbit ear. Vascular alpha1- and alpha2-ARs appear to be distributed differently across the arterioles and AVAs of the rabbit ear. Both alpha1- and alpha2-ARs appear to contribute to vasoconstriction of AVAs in the conscious rabbit ear. In contrast, alpha1-AR's (vs alpha2-ARs) appear to predominate in adrenergically mediated sympathetic vasoconstriction of arterioles.
authors.affiliation: Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina, 27157, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: L A
authors.initials: LA
authors.lastname: Koman
authors.forename: B P
authors.initials: BP
authors.lastname: Smith
authors.forename: E S
authors.initials: ES
authors.lastname: Gordon
authors.forename: T L
authors.initials: TL
authors.lastname: Smith
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D004431:Ear, External / Q000098:blood supply; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D020926:Medetomidine; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D008955:Models, Cardiovascular; D010656:Phenylephrine / Q000494:pharmacology; D011224:Prazosin / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology*; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology*; D012867:Skin / Q000098:blood supply*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology
chemical_list: D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D007093:Imidazoles; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2; C050701:atipamezole; D010656:Phenylephrine; C041226:Terazosin; D020926:Medetomidine; D011224:Prazosin