The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite.
The antibiotic micrococcin is a potent growth inhibitor of the human malaria parasite Plasmodium falciparum, with a 50% inhibitory concentration of 35 nM. This is comparable to or less than the corresponding levels of commonly used antimalarial drugs. Micrococcin, like thiostrepton, putatively targets protein synthesis in the plastid-like organelle of the parasite.
Rogers
M J
MJ
Growth and Development Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA.
Cundliffe
E
E
McCutchan
T F
TF
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D001430:Bacteriocins; D004305:Dose-Response Relationship, Drug; D010455:Peptides; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D015800:Protozoan Proteins / Q000096:biosynthesis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D001430:Bacteriocins; D010455:Peptides; D011500:Protein Synthesis Inhibitors; D015800:Protozoan Proteins; C009779:micrococcin