title: Cloning and expression of an immunoglobulin superfamily gene (IGSF1) in Xq25.
abstract: We have isolated a novel full-length cDNA for a gene (IGSF1) located in distal Xq25. This transcript is highly expressed in adult testis and fetal liver but is undetectable in adult liver. A smaller alternate form is highly expressed in adult heart. The gene encodes a protein of 1327 amino acids with several recognizable functional domains. The protein has a putative signal peptide and transmembrane region, 15 potential sites for N-linked glycosylation, and 12 C2-type immunoglobulin (Ig)-like domains. All of the Ig-like domains contain the two conserved cysteine residues that form intradomain disulfide bonds typical of this superfamily. These features are consistent with a possible role for this molecule in cell surface recognition or cell-cell interaction.
authors.affiliation: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. rich@genetics.wustl.edu
authors.forename: R
authors.initials: R
authors.lastname: Mazzarella
authors.forename: G
authors.initials: G
authors.lastname: Pengue
authors.forename: J
authors.initials: J
authors.lastname: Jones
authors.forename: C
authors.initials: C
authors.lastname: Jones
authors.forename: D
authors.initials: D
authors.lastname: Schlessinger
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D018507:Gene Expression Regulation, Developmental; D015723:Gene Library; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D008565:Membrane Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009928:Organ Specificity / Q000235:genetics; D018243:Teratocarcinoma; D014960:X Chromosome / Q000235:genetics*
chemical_list: C112314:IGSF1 protein, human; D007136:Immunoglobulins; D008565:Membrane Proteins