Isolation of a bioactive Ca(2+)-mobilizing complex lipid from bovine vitreous body.
Vitreous body extracts show a potent Ca(2+)-mobilizing activity on fibroblast cells. This Ca2+ signal is complex, and due to the presence of two different bioactive substances. The first one was identified as acid FGF. The second one was shown to be a low molecular weight substance identified as a complex lipid by a combination of chromatographic and biochemical data. This finding raises the possibility that non-classical substances with growth factor-like activity might play a role in the regulation of proliferative processes in the eye.
Camiña
J P
JP
Department of Medicine, Compostela University School of Medicine, Santiago de Compostela, Spain.
Casabiell
X A
XA
Pérez
F R
FR
Lage
M
M
Casanueva
F F
FF
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002417:Cattle; D016220:Fibroblast Growth Factor 1 / Q000302:isolation & purification / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D006133:Growth Substances / Q000302:isolation & purification* / Q000494:pharmacology; D008055:Lipids / Q000302:isolation & purification* / Q000494:pharmacology; D015398:Signal Transduction; D014822:Vitreous Body / Q000737:chemistry*
D006133:Growth Substances; D008055:Lipids; D016220:Fibroblast Growth Factor 1; D002118:Calcium