Expression of epidermal growth factor receptor in urinary bladder cancer metastases.
Bladder cancers frequently exhibit an increased number of epidermal growth factor receptors (EGFR) in comparison to normal urothelium. The EGFR could potentially be a target for toxic conjugates. The aim of our study was to compare the expression of EGFR in metastases with concurrent or primary tumour in the urinary bladder using immunohistochemical techniques and a monoclonal antibody. Tumour material from 20 patients was investigated. The majority (13/20) of the metastases were homogeneously stained and showed a moderate to strong membranous staining for EGFR. The expression of EGFR in primary bladder tumours and metastases was similar. There was no indication that tumour tissue exposed to chemotherapy or radiation had a decreased number of EGFR. Targeting of the EGFR thus seems potentially applicable to metastatic disease.
Bue
P
P
Department of Urology, Uppsala University, Sweden.
Wester
K
K
Sjöström
A
A
Holmberg
A
A
Nilsson
S
S
Carlsson
J
J
Westlin
J E
JE
Busch
C
C
Malmström
P U
PU
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000648:ultrastructure*; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006258:Head and Neck Neoplasms / Q000556:secondary / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary / Q000648:ultrastructure; D008175:Lung Neoplasms / Q000556:secondary / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010386:Pelvic Neoplasms / Q000556:secondary / Q000648:ultrastructure; D010412:Penile Neoplasms / Q000556:secondary / Q000648:ultrastructure; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000648:ultrastructure*
D066246:ErbB Receptors