[The neuropathies of IgM monoclonal gammopathies].
A peripheral polyneuropathy is often associated with an IgM monoclonal gammapathy. The monoclonal protein often binds to carbohydrate epitopes on glycoproteins and/or glycolipids of the human peripheral nerve. The clinical syndrome is related to the antigen-specificity of the IgM protein. Detection of anti-myelin antibodies and further characterization of their immunogenic specificity provide an important aid in the differential diagnosis of late-onset chronic polyneuropathies.
Humbel
R L
RL
Laboratoire d'Immunopathologie, Centre Hospitalier de Luxembourg.
Schmit
P
P
Gilson
G
G
D006017:Glycolipids / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology
D006017:Glycolipids; D007075:Immunoglobulin M
Les neuropathies des gammapathies monoclonales a IgM.