Activities of isoniazid alone and in combination with other drugs against Mycobacterium avium infection in beige mice.
Monotherapy with isoniazid or amikacin or clarithromycin or combinations of two of these drugs showed nil to modest therapeutic activity in beige mice infected with Mycobacterium avium. However, the combination of all three, isoniazid-amikacin-clarithromycin, markedly reduced CFUs in both spleens and lungs after 91 days of infection.
Fattorini
L
L
Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome, Italy.
Xiao
Y
Y
Mattei
M
M
Li
Y
Y
Iona
E
E
Ricci
M L
ML
Thoresen
O F
OF
Creti
R
R
Orefici
G
G
D000583:Amikacin / Q000494:pharmacology; D000818:Animals; D017291:Clarithromycin / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000382:microbiology; D051379:Mice; D009162:Mycobacterium avium / Q000187:drug effects*; D013154:Spleen / Q000187:drug effects / Q000382:microbiology; D014376:Tuberculosis / Q000188:drug therapy*
D000583:Amikacin; D017291:Clarithromycin; D007538:Isoniazid