Comparative study of the effects of several n-alkanes on phospholipid hexagonal phases.
The effects of a series of normal alkanes (decane, dodecane, tetradecane, hexadecane, and octadecane) on the hexagonal H(II) structures containing dioleoylphosphatidylethanolamine (DOPE) and dioleoylphosphatidylcholine (DOPC) were studied using x-ray diffraction and osmotic stress. The alkanes affect structural dimensions and the monolayer intrinsic curvature and bending modulus. The alkane effects are chain-length dependent and are attributed to their different distribution within the H(II) structure. The data suggest that short-chain alkanes are more uniformly distributed within the H(II) hydrocarbon regions and change the curvature and bending modulus of the monolayer, whereas longer-chain alkanes appear confined more to the interstitial region and do not change the curvature and bending modulus.
Chen
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Department of Biological Sciences, Brock University, St. Catharines, Ontario, Canada.
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D000473:Alkanes / Q000737:chemistry*; D004548:Elasticity; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D009994:Osmolar Concentration; D010713:Phosphatidylcholines / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D013314:Stress, Mechanical; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D014961:X-Ray Diffraction
D000473:Alkanes; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; C020888:1,2-dielaidoylphosphatidylethanolamine; C017251:1,2-oleoylphosphatidylcholine