title: T-cell lymphoma caused by herpesvirus saimiri C488 independently of ie14/vsag, a viral gene with superantigen homology.
abstract: The immediate-early gene ie14/vsag of herpesvirus saimiri has homology with murine superantigens. We compared the pathogenesis of infection with either ie14/vsag deletion mutants or wild-type virus C488 in cottontop tamarin monkeys (Saguinus oedipus). Two weeks after infection, all animals developed acute T-cell lymphomas independently of the presence of the viral ie14/vsag gene.
authors.affiliation: Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Knappe
authors.forename: M
authors.initials: M
authors.lastname: Thurau
authors.forename: H
authors.initials: H
authors.lastname: Niphuis
authors.forename: C
authors.initials: C
authors.lastname: Hiller
authors.forename: S
authors.initials: S
authors.lastname: Wittmann
authors.forename: E M
authors.initials: EM
authors.lastname: Kuhn
authors.forename: B
authors.initials: B
authors.lastname: Rosenwirth
authors.forename: B
authors.initials: B
authors.lastname: Fleckenstein
authors.forename: J
authors.initials: J
authors.lastname: Heeney
authors.forename: H
authors.initials: H
authors.lastname: Fickenscher
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000502:physiology*; D017353:Gene Deletion; D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000473:pathology / Q000821:virology*; D006567:Herpesvirus 2, Saimiriine / Q000235:genetics / Q000502:physiology*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000821:virology*; D012452:Saguinus; D018089:Superantigens / Q000235:genetics / Q000502:physiology*; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology*
chemical_list: D000956:Antigens, Viral; D018089:Superantigens