Influence of hyperinsulinemia on lipoproteins after pancreas transplantation with systemic insulin drainage.
Successful pancreas transplantation with systemic drainage is followed by a normalization of carbohydrate and lipid metabolism with low levels of plasma cholesterol and triglycerides. HDL cholesterol concentration and CETP plasma levels were found to be increased and the composition of lipoproteins altered in that LDL and HDL2/HDL3 were enriched in UC, HDL2 enriched in PL, and LDL depleted in PL. The mechanisms by which hyperinsulinemia may cause the observed changes in surface composition of plasma lipoproteins are unknown, as is their clinical relevance. It remains to be seen whether these changes counterbalance the favorable effects of an increased triglyceride clearance capacity on the cardiovascular risk of diabetic patients.
Königsrainer
A
A
University Hospital Innsbruck, Department of Transplantation, Austria.
Föger
B
B
Steurer
W
W
Lechleitner
M
M
Spechtenhauser
B
B
Riedmann
B
B
Patsch
J R
JR
Margreiter
R
R
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000601:surgery*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous
D008074:Lipoproteins