Aloe-emodin effects on arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori.
Arylamine N-acetyltransferase (NAT) activities with p-aminobenzoic acid (PABA) and 2-aminofluorene (AF) were determined in H. pylori collected from peptic ulcer patients. Cytosols or suspensions of H. pylori with or without different concentrations of aloe-emodin co-treatment showed different percentages of AF and PABA acetylation. The data indicate that there was decreased NAT activity associated with increased aloe-emodin in H. pylori cytosols. Inhibition of growth study from H. pylori demonstrated that aloe-emodin elicited dose-dependent growth inhibition in H. pylori cultures. The report is the first finding of aloe-emodin inhibition of arylamine NAT activity in a strain of H. pylori.
Wang
H H
HH
Chung
J G
JG
Ho
C C
CC
Wu
L T
LT
Chang
S H
SH
D000880:Anthraquinones; D001191:Arylamine N-Acetyltransferase / Q000037:antagonists & inhibitors*; D004642:Emodin / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D006801:Humans; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
D000880:Anthraquinones; D004791:Enzyme Inhibitors; C518327:aloe emodin; D001191:Arylamine N-Acetyltransferase; D004642:Emodin