Discriminative-stimulus and participant-rated effects of methylphenidate, bupropion, and triazolam in d-amphetamine-trained humans.
The discriminative-stimulus and participate-rated effects of a range of doses of d-amphetamine (2.5-20 mg), methylphenidate (5-40 mg), bupropion (50-400 mg), and triazolam (0.0625-0.5 mg) were tested in 5 humans trained to discriminate between oral d-amphetamine (20 mg) and placebo. d-Amphetamine and methylphenidate generally dose dependently increased drug-appropriate responding. Bupropion and triazolam on average occasioned less than or equal to 40% drug-appropriate responding. d-Amphetamine, methylphenidate, and bupropion produced stimulant-like participant-rated effects, while triazolam produced sedative-like effects. These results further demonstrate that the acute behavioral effects of d-amphetamine and methylphenidate overlap extensively in humans, which is concordant with preclinical studies. Bupropion produced some d-amphetamine-like, participant-rated drug effects but did not occasion significant levels of d-amphetamine-appropriate responding. These findings are concordant with previous findings of a dissociation between the discriminative-stimulus and participant-rated effects of drugs.
Rush
C R
CR
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39219-4505, USA. crush@fiona.umsmed.edu
Kollins
S H
SH
Pazzaglia
P J
PJ
D000328:Adult; D000339:Affect / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D016642:Bupropion / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D005260:Female; D018757:GABA Modulators / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects; D014229:Triazolam / Q000494:pharmacology*
D018765:Dopamine Uptake Inhibitors; D018757:GABA Modulators; D016642:Bupropion; D014229:Triazolam; D008774:Methylphenidate; D003913:Dextroamphetamine