Radiographic, densitometric, and biomechanical effects of recombinant canine somatotropin in an unstable ostectomy gap model of bone healing in dogs.
OBJECTIVE
To determine the effect of recombinant canine somatotropin (STH) on radiographic, densitometric, and biomechanical aspects of bone healing using an unstable ostectomy gap model.


METHODS
After an ostectomy of the midshaft radius, bone healing was evaluated over an 8-week period in control dogs (n = 4) and dogs receiving recombinant canine STH (n = 4).


METHODS
Eight sexually intact female Beagle dogs, 4 to 5 years old.


METHODS
Bone healing was evaluated by qualitative and quantitative evaluation of serial radiographs every 2 weeks. Terminal dual-energy x-ray absorptiometry and three-point bending biomechanical testing were also performed.


RESULTS
Dogs receiving STH had more advanced radiographic healing of ostectomy sites. Bone area, bone mineral content, and bone density were two to five times greater at the ostectomy sites of treated dogs. Ultimate load at failure and stiffness were three and five times greater in dogs receiving STH.


CONCLUSIONS
Using the ostectomy gap model, recombinant canine STH enhanced the radiographic, densitometric, and biomechanical aspects of bone healing in dogs.


CONCLUSIONS
Dogs at risk for delayed healing of fractures may benefit from treatment with recombinant canine STH.
Millis
D L
DL
Department of Small Animal Clinical Sciences, University of Tennessee, USA.
Wilkens
B E
BE
Daniel
G B
GB
Hubner
K
K
Mathews
A
A
Buonomo
F C
FC
Patell
K R
KR
Weigel
J P
JP
D015502:Absorptiometry, Photon / Q000662:veterinary; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D004285:Dogs / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000235:genetics / Q000494:pharmacology*; D010027:Osteotomy / Q000662:veterinary; D011884:Radius / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000601:surgery; D011897:Random Allocation; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology
D011994:Recombinant Proteins; D013006:Growth Hormone