title: High-performance liquid chromatographic assay of 8-hydroxyquinoline sulfate and its stability in immunobiological preparations.
abstract: Because of the ability of 8-hydroxyquinoline sulfate (8-HQS) to irreversibly bind metals from rubber stoppers, the stability of 8-HQS in tuberculin solutions was investigated. For the determination of 8-HQS, a simple and sensitive reversed-phase HPLC method with detection at 240 nm was developed and validated. Rapid decreases in concentrations of 8-HQS were found in samples stored in original vials which were exposed to different temperatures and vial positions.
authors.affiliation: Control Department, TORLAK, Belgrade, Yugoslavia.
authors.forename: A
authors.initials: A
authors.lastname: Mihajlović
authors.forename: D
authors.initials: D
authors.lastname: Agbaba
authors.forename: D
authors.initials: D
authors.lastname: Zivanov-Stakić
authors.forename: P
authors.initials: P
authors.lastname: Ristić
authors.forename: M
authors.initials: M
authors.lastname: Dordjević
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004340:Drug Contamination; D004355:Drug Stability; D004356:Drug Storage; D007700:Kinetics; D015125:Oxyquinoline / Q000032:analysis*; D013696:Temperature; D014373:Tuberculin / Q000032:analysis*
chemical_list: D014373:Tuberculin; D015125:Oxyquinoline