title: The significance of family history status in relation to neuropsychological test performance and cerebral glucose metabolism studied with positron emission tomography in older alcoholic patients.
abstract: Patients with severe chronic alcoholism have decreased rates of glucose metabolism in the medial frontal lobe and correlated abnormalities of neuropsychological functioning. The potential influence of family history of alcoholism has not been examined in these patients. In a retrospective study, we used neuropsychological tests and neuroimaging employing [18F]fluorodeoxyglucose with positron emission tomography to study 48 older subjects who had histories of severe, chronic alcohol dependence. These patients were divided into two groups: 27 with a first-degree relative with chronic alcoholism and 21 patients without first-degree relative with chronic alcoholism. No differences were found between groups on either neuropsychological or neuroimaging tests. These results suggest that a family history of alcoholism does not moderate the damaging effects of severe chronic alcoholism on the functioning of the medial frontal lobe.
authors.affiliation: Ann Arbor Veteran's Affairs Medical Center, Department of Psychiatry, University of Michigan, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Adams
authors.forename: S
authors.initials: S
authors.lastname: Gilman
authors.forename: D
authors.initials: D
authors.lastname: Johnson-Greene
authors.forename: R A
authors.initials: RA
authors.lastname: Koeppe
authors.forename: L
authors.initials: L
authors.lastname: Junck
authors.forename: K J
authors.initials: KJ
authors.lastname: Kluin
authors.forename: S
authors.initials: S
authors.lastname: Martorello
authors.forename: M J
authors.initials: MJ
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Heumann
authors.forename: E
authors.initials: E
authors.lastname: Hill
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000000981:diagnostic imaging / Q000235:genetics* / Q000534:rehabilitation; D001786:Blood Glucose / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18