title: Modulation of morphine-6-glucuronide penetration into the brain by P-glycoprotein.
authors.affiliation: Department of Research and Gastroenterology, University Hospital, Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Huwyler
authors.forename: J
authors.initials: J
authors.lastname: Drewe
authors.forename: H
authors.initials: H
authors.lastname: Gutmann
authors.forename: M
authors.initials: M
authors.lastname: Thöle
authors.forename: G
authors.initials: G
authors.lastname: Fricker
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002478:Cells, Cultured; D004058:Diffusion; D018432:Drug Resistance, Multiple; D004730:Endothelium, Vascular / Q000378:metabolism*; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000032:analysis; D009020:Morphine / Q000493:pharmacokinetics; D009022:Morphine Derivatives / Q000493:pharmacokinetics*; D010750:Phosphoproteins / Q000032:analysis; D011433:Propranolol / Q000493:pharmacokinetics; D013395:Sucrose / Q000493:pharmacokinetics; D013552:Swine; D014746:Vimentin / Q000032:analysis; D062826:Zonula Occludens-1 Protein; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008565:Membrane Proteins; D009022:Morphine Derivatives; D010750:Phosphoproteins; D014746:Vimentin; D062826:Zonula Occludens-1 Protein; D014841:von Willebrand Factor; D013395:Sucrose; C035349:morphine-6-glucuronide; D009020:Morphine; D011433:Propranolol