Nonadhesive liquid embolic agent: role of its components in histologic changes in embolized arteries.
OBJECTIVE
The authors evaluated the safety and efficacy of a nonadhesive liquid embolic material and the role of its components in histologic changes in embolized arteries.


METHODS
A Eudragit-E mixture (Rohm Chemische Fabrik, Darmstadt, Germany) was made of a cationic copolymer (Eudragit-E) dissolved in an equal volume of absolute ethanol and iopamidol. The Eudragit-E mixture, an ethanol-iopamidol mixture, and an iopamidol-saline mixture were injected into 12 rabbit renal arteries each. Three rabbits from each group were followed up for 1 day, 1 week, 1 month, and 3 months, at which time they were sacrificed. Kidneys were removed for histologic examination.


RESULTS
The Eudragit-E mixture occluded all renal arteries without difficulty: the arteries did not recanalize. Histologically, acute vasculitis was caused by both the Eudragit-E and ethanol-iopamidol mixtures, but not by the iopamidol-saline mixture. Small infarctions were elicited with the ethanol-iopamidol mixture but not with the iopamidol-saline mixture.


CONCLUSIONS
The Eudragit-E mixture is effective and easy to handle. Fifty percent ethanol may play a role in vessel occlusion with Eudragit-E mixture and in acute vasculitis.
Sadato
A
A
Department of Radiology, University of Rochester, NY, USA.
Numaguchi
Y
Y
Taki
W
W
Iwata
H
H
Yamshita
K
K
D000818:Animals; D004621:Embolization, Therapeutic; D000431:Ethanol; D007479:Iopamidol; D007668:Kidney / Q000473:pathology; D008689:Methacrylates; D008768:Methylmethacrylates; D011817:Rabbits; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000473:pathology
D008689:Methacrylates; D008768:Methylmethacrylates; C102808:Eudragit-E; D000431:Ethanol; D007479:Iopamidol