Pathological features of healing of a ruptured human round window membrane.
Pathology of a round window membrane rupture was demonstrated in a human temporal bone from a case in which labyrinthotomy had been performed through the round window membrane. Proliferation of mesothelial cells was seen in the inner layer of the membrane, and it appeared to be reinforced from the inside by these reactive cells. The middle layer of the membrane was thickened by increased collagen and elastin. The pathologic changes which take place during healing of the ruptured round window membrane are discussed.
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Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, USA.
D000328:Adult; D001933:Brain Stem / Q000473:pathology; D002465:Cell Movement / Q000502:physiology; D003094:Collagen / Q000032:analysis; D004549:Elastin / Q000032:analysis; D004847:Epithelial Cells / Q000378:metabolism; D017809:Fatal Outcome; D006097:Granulation Tissue / Q000737:chemistry; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D008297:Male; D009410:Nerve Degeneration / Q000150:complications / Q000473:pathology; D012405:Round Window, Ear / Q000737:chemistry / Q000293:injuries*; D012421:Rupture / Q000150:complications; D014945:Wound Healing
D003094:Collagen; D004549:Elastin