title: Quick response of advanced cancer to chemoradiation therapy with antineoplastons.
abstract: Antineoplastons A10 and AS2-1 exhibit growth inhibition of cancer cells by diverse modes of action. We observed antitumor responses within 2-3 weeks of a combination treatment of chemoradiation therapy and antineoplastons A10 and AS2-1 in phase I clinical study being conducted in Kurume University Hospital. We reviewed 3 clinical cases of advanced cancer (multiple metastatic lung cancer, thalamic glioma and primary lung cancer) in which we believed antineoplaston A10 and AS2-1 may be contributing to the rapid antitumor response. The possible use of this combination for induction therapy in advanced cancer is discussed.
authors.affiliation: Department of Anesthesiology, Kurume University, School of Medicine, 67 Asahimachi, Kurumeshi, Fukuokaken, 830, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsuda
authors.forename: M
authors.initials: M
authors.lastname: Sata
authors.forename: T
authors.initials: T
authors.lastname: Kumabe
authors.forename: H
authors.initials: H
authors.lastname: Hara
authors.forename: N
authors.initials: N
authors.lastname: Eriguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Sugita
authors.forename: H
authors.initials: H
authors.lastname: Nagamatsu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D044482:Benzeneacetamides; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy*; D018287:Carcinoma, Large Cell / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000628:therapy*; D005973:Glutamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000627:therapeutic use*; D010881:Piperidones / Q000627:therapeutic use*; D011878:Radiotherapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D044482:Benzeneacetamides; D004338:Drug Combinations; D010648:Phenylacetates; D010881:Piperidones; D005973:Glutamine; C092038:antineoplaston AS 2-1; C052091:antineoplaston A10