Localization of TGF-beta and its receptors in the kidney.
This paper reviews the expression and localization of proteins of the TGF-beta system in the kidney, i.e. TGF-beta isoforms, latent TGF-beta binding protein, and receptors. There is heterogeneity of TGF-beta isoforms, binding proteins and receptors. TGF-betas are more evenly distributed among different segments of the nephron than TGF-beta receptors, and are expressed by almost all cell types in the kidney. The spatial distribution of TGF-beta and its signaling receptor may help to better understand the biologic function of TGF-beta in the kidney.
Ando
T
T
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan. tando@med.kyushu-u.ac.jp
Okuda
S
S
Yanagida
T
T
Fujishima
M
M
D000818:Animals; D002352:Carrier Proteins / Q000032:analysis / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins; D007668:Kidney / Q000737:chemistry*; D053779:Latent TGF-beta Binding Proteins; D012333:RNA, Messenger / Q000032:analysis; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis* / Q000235:genetics; D014018:Tissue Distribution; D016212:Transforming Growth Factor beta / Q000032:analysis* / Q000235:genetics
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D053779:Latent TGF-beta Binding Proteins; D012333:RNA, Messenger; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta