title: [Hep-A-in-Vac, a Russian cultured concentrated inactivated vaccine against hepatitis A].
abstract: The results of the study of the reactogenicity, safety and immunological activity of Russian cultural vaccine against hepatitis A are presented. The vaccine was found to have specific safety, moderate reactogenicity and pronounced immunological activity. In addition, the study of the prophylactic efficiency of the vaccine in the pre-epidemic period of the outbreak of hepatitis A morbidity in a group exceeding 14,000 adults was carried out. The study revealed high prophylactic efficiency of the vaccine (its efficiency rate was equal to 97.7%). On the basis of materials thus obtained vaccine "Hep-A-in-Vac" was recommended for use in medical practice for the prophylaxis of hepatitis A among adults.
authors.affiliation: Tarasevich State Research Institute for Standartization and Control of Medical Biological Preparations, Moscow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Gorbunov
authors.forename: L I
authors.initials: LI
authors.lastname: Pavlova
authors.forename: S D
authors.initials: SD
authors.lastname: Rozhkov
authors.forename: A I
authors.initials: AI
authors.lastname: Kukharev
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Novikov
authors.forename: L G
authors.initials: LG
authors.lastname: Karpovich
authors.forename: T V
authors.initials: TV
authors.lastname: Kalashnikova
authors.forename: T A
authors.initials: TA
authors.lastname: Bektimirov
authors.forename: I A
authors.initials: IA
authors.lastname: Zelenov
authors.forename: V D
authors.initials: VD
authors.lastname: Levina
authors.forename: B P
authors.initials: BP
authors.lastname: Belashev
authors.forename: T N
authors.initials: TN
authors.lastname: Ermolaeva
authors.forename: N V
authors.initials: NV
authors.lastname: Doroshenko
authors.forename: A T
authors.initials: AT
authors.lastname: Maĭdaniuk
mesh_terms: D000293:Adolescent; D000328:Adult; D006506:Hepatitis A / Q000453:epidemiology / Q000517:prevention & control*; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology; D006801:Humans; D008297:Male; D012426:Russia / Q000453:epidemiology; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D006508:Hepatitis Antibodies; D017325:Hepatitis B Vaccines; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines
vernacular_title: Izuchenie otechestvennoĭ kul'tural'noĭ kontsentrirovannoĭ inaktivirovannoĭ vaktsiny protiv gepatita A "Gep-A-in-Vak".