Two nosocomial strains of Stenotrophomonas maltophilia transferring antibiotic resistance to Proteus mirabilis P-38 recipient strain.
In this report we describe a specific transfer of carbenicillin and cephaloridine resistance determinants from two different strains of Stenotrophomonas maltophilia: No. 215 and 221 isolated from two critically ill patients treated in different Intensive Care Units of a large University Hospital in Ostrava, Czech Republic. These strains were resistant to flouroquinolones and the following beta-lactam drugs: carbenicillin, cephaloridine, cefotaxime, ceftazidime, cefepime, imipenem, meropenem and aztreonam. Both strains transferred carbenicillin and cephaloridine resistance determinants, with rather different frequency, to Proteus mirabilis P-38. All carbenicillin-selected transconjugants were found by an indirect selection method to be co-resistant to cephaloridine only. In a second cycle of transfers Proteus mirabilis R+ strains directly transferred carbenicillin and cephalothin determinants to Escherichia coli K-12 No. 185 nal+ lac+ recipient strain.
Blahová
J
J
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Králiková
K
K
Krcméry
V
V
Chmelarová
E
E
Torsová
V
V
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002228:Carbenicillin / Q000494:pharmacology; D002509:Cephaloridine / Q000494:pharmacology; D003470:Culture Media; D018153:Czech Republic; D018432:Drug Resistance, Multiple; D024841:Fluoroquinolones; D006801:Humans; D007362:Intensive Care Units; D011513:Proteus mirabilis / Q000187:drug effects* / Q000235:genetics; D014974:Xanthomonas / Q000187:drug effects* / Q000235:genetics; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000032:analysis / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003470:Culture Media; D024841:Fluoroquinolones; D001618:beta-Lactamases; D002228:Carbenicillin; D002509:Cephaloridine