Aspergillus flavus endocarditis in a child with neuroblastoma.
We report a case of Aspergillus flavus endocarditis in a 6-year-old boy with stage IV neuroblastoma with no pre-existing cardiac disease. The infection was successfully treated with high-dose liposomal amphotericin (AmBisome) once daily. Recurrence was prevented with itraconazole oral solution once daily as maintenance therapy. Adjunctive surgery was not required. The patient's cardiac function was uncompromised, but subsequent death from progressive neuroblastoma prevented long-term follow-up.
Kennedy
H F
HF
Department of Microbiology, Royal Hospital for Sick Children, Yorkhill NHS Trust, Glasgow, UK.
Simpson
E M
EM
Wilson
N
N
Richardson
M D
MD
Michie
J R
JR
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D001231:Aspergillus flavus; D002648:Child; D004696:Endocarditis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000150:complications*
D000935:Antifungal Agents; D000666:Amphotericin B