title: Analysis of vessel wall morphology, blood flow velocity, and the hemostatic system in a patient with a large intracoronary thrombus.
abstract: A patient with AMI caused by a large thrombus in the proximal LAD was successfully treated with PTCA and an intracoronary lysis combined with the platelet-receptor antagonist c7E3. Analysis of cellular hemostasis after 1 and 6 months revealed a sustained platelet activation despite combined anti-platelet therapy with ASA and ticlopidine. A progredient slow-flow phenomenon appeared during control angiographies, confirmed by intracoronary Doppler examination.
authors.affiliation: Department of Cardiology, University of Essen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Haude
authors.forename: C
authors.initials: C
authors.lastname: Altmann
authors.forename: B
authors.initials: B
authors.lastname: Eick
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.forename: B
authors.initials: B
authors.lastname: Schwippert
authors.forename: D
authors.initials: D
authors.lastname: Tschöpe
authors.forename: R
authors.initials: R
authors.lastname: Erbel
mesh_terms: D000077284:Abciximab; D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D001783:Blood Flow Velocity; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects; D003328:Coronary Thrombosis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D015539:Platelet Activation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D018084:Ultrasonography, Interventional; D014654:Vascular Patency
chemical_list: D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D000077284:Abciximab