2-methyl-3-acetyl-4-aryl-5-oxo-1,4-dihydro-5H indeno(1,2-b) pyridine derivatives studies and their calcium antagonistic activities.
Sixteen 2-methyl-3-acetyl-4-aryl-5-oxo-1,4-dihydro-5H-indeno(1,2-b)pyridine derivatives (3a-p) have been prepared. The structures of the compounds were characterised by IR, 1H-NMR, 13C-NMR, X-Ray and elemental analyses. The calcium antagonistic activity of these compounds were studied in rat taenia coli pre-contracted with 1 mmol/l Ca+2.
Safak
C
C
Department of Pharmaceutical Chemistry Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Simsek
R
R
Altas
Y
Y
Boydag
S
S
Erol
K
K
D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007192:Indenes / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D002121:Calcium Channel Blockers; D007192:Indenes; D011725:Pyridines