[Effect of RB-101, inhibitor of enkephalin degrading enzymes, on recovery of conductivity of the injured sciatic nerve in rats].
A dose-dependent effect of the enkephalinase RB-101 on functional recovery of the rat injured sciatic nerve was revealed. The findings suggest the enkephalines participation in regulation of regenerative processes in peripheral nerves.
Kolosova
L I
LI
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, Russia.
Moiseeva
A B
AB
Riabchikova
O V
OV
Akoev
G N
GN
D000200:Action Potentials / Q000187:drug effects; D000626:Aminopeptidases / Q000037:antagonists & inhibitors*; D000818:Animals; D004220:Disulfides / Q000494:pharmacology*; D004745:Enkephalins / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D009431:Neural Conduction / Q000187:drug effects* / Q000502:physiology; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects* / Q000293:injuries / Q000502:physiology
D004220:Disulfides; D004745:Enkephalins; D004791:Enzyme Inhibitors; C074024:RB 101; D010649:Phenylalanine; D000626:Aminopeptidases; C025579:enkephalin degrading enzyme
Vliianie RB-101, blokatora fermentov, razrushaiushchikh énkefaliny, na vosstanovlenie provodimosti povrezhdennogo sedalishchnogo nerva krysy.