title: [West's syndrome associated with inversion duplication of chromosome 15].
abstract: We describe a five year old boy with inversion duplication of chromosome 15 (inv dup (15)) who, at the age of six months had started to develop West's syndrome. He later developed cryptogenic myoclonic epilepsy which was resistant to medication. On examination there was dysmorphia, overall hypotonia and diffuse pyramidalism. On starting ACTH the crises of flexion spasms were reduced but these were soon followed by myoclonic crises, both tonic and atonic, which did not respond to the various anticonvulsive treatments given. We comment on the changes in chromosome 15 linked to convulsions, and particularly the phenotypes of the inv dup (15) which depend on the size and genetic composition of the anomaly. This is the third case described in the literature of a patient with West's syndrome associated with supernumerary inversion duplication of chromosome 15. It is suggested that the karyotype be included when studying convulsive encephalopathies and cryptogenic refractory epilepsy, especially in infantile spasms.
authors.affiliation: Sección de Neuropediatria, Hospital Materno-Infantil de Las Palmas de Gran Canaria, España.
authors.forename: J C
authors.initials: JC
authors.lastname: Cabrera
authors.forename: M
authors.initials: M
authors.lastname: Martí
authors.forename: L
authors.initials: L
authors.lastname: Toledo
authors.forename: R
authors.initials: R
authors.lastname: Giné
authors.forename: C
authors.initials: C
authors.lastname: Vázquez
mesh_terms: D002675:Child, Preschool; D007446:Chromosome Inversion; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D006801:Humans; D008297:Male; D005810:Multigene Family / Q000235:genetics*; D013036:Spasms, Infantile / Q000235:genetics*
vernacular_title: Síndrome de West asociado a inversión duplicación del cromosoma 15.