Intrachromosomal telomeric repeats and stabilization of truncated chromosomes in V79 Chinese hamster cells.
(TTAGGG)n sequences have been localized on the chromosomes of the Chinese hamster V79 cell line. A correlation between telomeric-like repeats and chromosome breakage has been found. Moreover, the analysis of the truncated chromosomes, typical of this cell line, has suggested that intrachromosomal (TTAGGG)n DNA may be important in the stabilization of the new telomeres.
Simi
S
S
Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy. s.simi@imd.pi.cnr.it
Attolini
C
C
Giulotto
E
E
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D017404:In Situ Hybridization, Fluorescence; D008677:Metaphase; D016615:Telomere