title: Identification and characterization of a myomodulin-like peptide in the leech.
abstract: A novel myomodulin-like peptide, GMGALRLamide, has been purified and sequenced from extracts of 1000 medicinal leech nerve cords. Synthetic leech myomodulin-like peptide blocked the specific staining pattern of leech ganglia by the antiserum against Aplysia myomodulin A PMGMLRLamide. Moreover, the synthetic leech myomodulin-like peptide GMGALRLamide showed identical neuronal modulation effect on the giant leech Retzius cell compare to that by the synthetic Aplysia myomodulin A PMGMLRLamide.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: D A
authors.initials: DA
authors.lastname: Price
authors.forename: C L
authors.initials: CL
authors.lastname: Sahley
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007118:Immunoassay; D007865:Leeches / Q000737:chemistry*; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D009479:Neuropeptides; C053302:myomodulin