title: Evaluation of myocardial ischemia in Kawasaki disease by dobutamine stress signal-averaged ventricular late potentials.
abstract: OBJECTIVE
  To determine the possibility of diagnosing myocardial ischemia from signal-averaged electrocardiographic late potentials (LPs) in patients with Kawasaki disease.
  
  
  METHODS
  Dobutamine stress LPs were obtained in 85 children with a history of Kawasaki disease (48 without coronary artery lesions, 19 with coronary artery lesions without myocardial ischemia, and 18 with myocardial ischemia). The infusion of dobutamine was started at 5 micrograms/kg/min, increased to 30 micrograms/kg/min. The presence of LPs was determined by the filtered QRS duration, the root mean square voltage during the last 40 ms, and the duration of the signal under 40 microV.
  
  
  RESULTS
  Among the children without coronary lesions, LPs were detected in 4.2% at rest and in 2.1% with dobutamine stress. Among the group with coronary lesions but without ischemia, LPs were found in 5.3% at rest and in 5.3% with stress. In the group with ischemia, LPs were present in 44.4% at rest and in 77.8% with stress. The sensitivity for myocardial ischemia was 72.7% at rest and 87.5% with stress (p < 0.05), and the specificity was 86.5% at rest and 94.2% with stress.
  
  
  CONCLUSIONS
  LPs associated with dobutamine stress testing are useful for identifying myocardial ischemia in children with Kawasaki disease, especially in those who cannot tolerate testing involving physical exercise.
authors.affiliation: Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Genma
authors.forename: S
authors.initials: S
authors.lastname: Ogawa
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000293:Adolescent; D000318:Adrenergic beta-Agonists; D000328:Adult; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004280:Dobutamine; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000209:etiology*; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted
chemical_list: D000318:Adrenergic beta-Agonists; D004280:Dobutamine