Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major.
We characterized the effects of Leishmania infection on activation-induced translocation of protein kinase C (PKC) isoforms in murine bone marrow-derived macrophages. Although PKC-dependent gene expression was attenuated by infection, the distribution and translocation of PKC isoforms were unaffected. However, subsequent dissociation from membranes was substantially delayed for some isoforms, particularly PKCbeta.
Pingel
S
S
Department of Medicine, University of California San Francisco, 94143-0654, USA.
Wang
Z E
ZE
Locksley
R M
RM
D000818:Animals; D007527:Isoenzymes / Q000032:analysis*; D018320:Leishmania major / Q000502:physiology*; D008264:Macrophages / Q000201:enzymology* / Q000469:parasitology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011493:Protein Kinase C / Q000032:analysis*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D007527:Isoenzymes; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate