title: Bilateral choroidal metastases as the initial presentation of a small breast carcinoma: a case report.
abstract: Most ocular tumors metastasize from systemic origins in breast carcinoma in females, and bronchial carcinoma in males. Here, we report a case of choroidal carcinoma metastasis from the breast with visual problems being the only initial manifestations. In this case, both eyes were involved at almost the same time, with initial manifestation of blurred vision which progressed to complete visual loss. At first, the patient was diagnosed with malignant melanoma, and enucleation of the right eye was performed in another hospital. However, the tumor had already metastasized rapidly to numerous organs, including the lungs, brain and bone, although it had not affected the liver. Clinical presentations were, therefore, not compatible with those of malignant melanoma, which has usually been reported to metastasize to the liver. Persistent hypercalcemia and raised carcinoembryonic antigen (CEA) concentrations prompted investigations into the possibility of systemic malignancy. A very small breast nodule was finally located by thorough physical examination, and a lumpectomy was performed. A detailed review of the histopathology showed the tumors from the breast and the right eye to have the same origin. Simultaneous bilateral choroidal metastases from other malignancies is not uncommon; however, it is quite rare for breast carcinoma to present with visual problems as a first manifestation. Detailed history taking and physical examination are therefore essential when searching for a primary tumor, so that appropriate therapy can be given earlier.
authors.affiliation: Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan, ROC.
authors.forename: Y R
authors.initials: YR
authors.lastname: Chen
authors.forename: T H
authors.initials: TH
authors.lastname: Lin
authors.forename: S M
authors.initials: SM
authors.lastname: Chan
authors.forename: S W
authors.initials: SW
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: K C
authors.initials: KC
authors.lastname: Ho
authors.forename: J H
authors.initials: JH
authors.lastname: Young
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology*; D002830:Choroid Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans