Synergy of antibiotics against Streptomyces somaliensis isolates in vitro.
Eight dual antibiotic combinations were used to investigate possible synergic effects against different isolates of Streptomyces somaliensis. The antibiotic combinations that showed synergic activity against the isolates were, in decreasing order, fusidic acid-rifampicin, erythromycin-penicillin, erythromycin-fusidic acid, rifampicin-sulphamethoxazole, fusidic acid-sulphamethoxazole and erythromycin-rifampicin. Sulphamethoxazole-trimethoprim and rifampicin-trimethoprim combinations were not synergic against any of the S. somaliensis isolates tested.
Nasher
M A
MA
Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Sana'a University, Republic of Yemen.
Hay
R J
RJ
D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004917:Erythromycin / Q000494:pharmacology; D005672:Fusidic Acid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013302:Streptomyces / Q000187:drug effects*; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
D010406:Penicillins; D005672:Fusidic Acid; D004917:Erythromycin; D014295:Trimethoprim; D013420:Sulfamethoxazole; D012293:Rifampin