Unraveling the mystery of HLA-B27 association with human spondyloarthropathies using transgenic and knock out mice.
Human spondyloarthropathies have a strong association with the presence of MHC class I allele, HLA-B27. Spondyloarthropathies occur predominantly in males and are usually triggered by an infection with an enterobacteria. Similar to human disease, experimental animals with HLA-B27 transgene also develop spontaneous inflammatory disease. In addition to HLA-B27, the role of environmental antigens has also been implicated in the animal models. How bacteria interact with HLA-B27 is not yet clearly understood. By breeding HLA-B27 transgenic mice with various transgenic and knock out mice, we investigated the immune mechanism in this inflammatory disease. In this review, we will summarize our recent findings and propose a hypothesis.
Khare
S D
SD
Department of Immunology, Mayo Clinic and Medical School, Rochester, MN 55905, USA.
Luthra
H S
HS
David
C S
CS
D000818:Animals; D000938:Antigen-Presenting Cells; D001168:Arthritis / Q000276:immunology*; D001324:Autoantigens; D001665:Binding Sites; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D006680:HLA Antigens; D015796:HLA-B27 Antigen / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D001613:beta 2-Microglobulin / Q000276:immunology
D001324:Autoantigens; D006680:HLA Antigens; D015796:HLA-B27 Antigen; D000949:Histocompatibility Antigens Class II; D007143:Immunoglobulin Heavy Chains; D001613:beta 2-Microglobulin