title: Atypical hyperplasia in the era of stereotactic core needle biopsy.
abstract: OBJECTIVE
  To characterize both atypical hyperplasia (AH) and the malignancies typically present at open surgical biopsy in women diagnosed with AH by stereotactic core needle biopsy (SCNB).
  
  
  METHODS
  Patients with AH diagnosed by SCNB were advised to undergo surgical biopsy to rule out an associated malignancy. Mammography findings, pathology reports and follow-up data were analyzed.
  
  
  RESULTS
  AH was identified by SCNB in 38 of 893 (4.3%) patients. Carcinoma was identified in 12 of 33 (36.4%) patients who went on to surgical biopsy. Ductal carcinoma in situ (DCIS) was present in 11 of the 12 patients with malignancy. There were no characteristic mammographic findings which would identify patients with carcinoma.
  
  
  CONCLUSIONS
  When SCNB returns a diagnosis of AH there is a substantial risk of an associated malignancy in the breast. There appear to be no definitive criteria to distinguish which patients harbor a malignancy, and surgical biopsy should always serve as an adjunct diagnostic procedure.
authors.affiliation: Department of Surgery, Madigan Army Medical Center, Tacoma, Washington 98431-5000, USA. Tommy_A_Brown@smtplink.mamc.amedd.army.mil
authors.forename: T A
authors.initials: TA
authors.lastname: Brown
authors.forename: J W
authors.initials: JW
authors.lastname: Wall
authors.forename: E D
authors.initials: ED
authors.lastname: Christensen
authors.forename: D V
authors.initials: DV
authors.lastname: Smith
authors.forename: C A
authors.initials: CA
authors.lastname: Holt
authors.forename: P L
authors.initials: PL
authors.lastname: Carter
authors.forename: T H
authors.initials: TH
authors.lastname: Patience
authors.forename: S S
authors.initials: SS
authors.lastname: Babu
authors.forename: W C
authors.initials: WC
authors.lastname: Williard
mesh_terms: D001707:Biopsy, Needle / Q000379:methods*; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008327:Mammography