title: Lateralised semantic and indirect semantic priming effects in people with schizophrenia.
abstract: BACKGROUND
  In schizophrenia, disturbances in the development of physiological hemisphere asymmetry are assumed to play a pathogenetic role. The most striking difference between hemispheres is in language processing. The left hemisphere is superior in the use of syntactic or semantic information, whereas the right hemisphere uses contextual information more effectively.
  
  
  METHODS
  Using psycholinguistic experimental techniques, semantic associations were examined in 38 control subjects, 24 non-thought-disordered and 16 thought-disordered people with schizophrenia, for both hemispheres separately.
  
  
  RESULTS
  Direct semantic priming did not differ between the hemispheres in any of the groups. Only thought-disordered people showed significant indirect semantic priming in the left hemisphere.
  
  
  CONCLUSIONS
  The results support: (a) a prominent role of the right hemisphere for remote associations; (b) enhanced spreading of semantic associations in thought-disordered subjects; and (c) disorganisation of the functional asymmetry of semantic processing in thought-disordered subjects.
authors.affiliation: University of Heidelberg, Psychiatric Hospital, Germany. MatthiasvWeisbrod@krzmail.krz.uni-heidelberg.de
authors.forename: M
authors.initials: M
authors.lastname: Weisbrod
authors.forename: S
authors.initials: S
authors.lastname: Maier
authors.forename: S
authors.initials: S
authors.lastname: Harig
authors.forename: U
authors.initials: U
authors.lastname: Himmelsbach
authors.forename: M
authors.initials: M
authors.lastname: Spitzer
mesh_terms: D000704:Analysis of Variance; D007839:Functional Laterality; D006801:Humans; D008297:Male; D011578:Psycholinguistics; D012564:Schizophrenic Language; D012565:Schizophrenic Psychology; D013850:Thinking; D014936:Word Association Tests