[An exceptional variety of medulloblastoma: melanotic medulloblastoma].
We report a new case of melanotic medulloblastoma of the vermis in a 3 1/2 year old boy. This tumor showed a typical histological appearance with pseudoepithelial pigmented structures immunoreactive for S100 protein and vimentin. The tumor did not recur after total surgical removal and post operative radiation. However, after a 10 year follow-up, imaging demonstrated that a second tumor occurred in the left cerebellar hemisphere, which, on histological examination, was a typical glioblastoma. Hypothesis concerning the histogenesis of the second tumor, as well as a causal association with radiation therapy and possible contribution of growth hormone therapy are discussed.
Baylac
F
F
Laboratoire d'Anatomie Pathologique, Faculté de Médecine, Vandaeuvre-les-Nancy.
Martinoli
A
A
Marie
B
B
Bracard
S
S
Marchal
J C
JC
Bey
P
P
Sommelet
D
D
Hassoun
J
J
Plénat
F
F
D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000378:metabolism / Q000473:pathology*; D008543:Melanins / Q000096:biosynthesis*
D008543:Melanins
Une variété exceptionnelle de médulloblastome: le médulloblastome mélanotique.