Disposition of human drug preparations in the horse. VI. Tiaprofenic acid.
Urinary and plasma concentrations of the nonsteroidal anti-inflammatory drug tiaprofenic acid were determined following oral and intramuscular administration of a dose of 1 g to five fasted horses. Quantitation was performed by high-performance liquid chromatography (HPLC). The limit of quantitation (LOQ) was 0.1 microg/ml and 0.5 microg/ml in 2 ml plasma and 1 ml urine, respectively. Assay precision and extraction recovery were between acceptable values. Tiaprofenic acid pharmacokinetics were described by non-compartment analysis of the data. Absorption was faster after oral administration as maximum plasma concentrations (oral: 6.0+/-3.3 microg/ml; intramuscular: 6.6+/-2.5 microg/ml) were obtained after 1 h (oral) compared to 1.6+/-0.4 h (intramuscular) post dosage. Plasma binding (66+/-3%) was lower than measured in other species. Tiaprofenic acid was detected in urine for at least 24 h. The percentage of the parent drug excreted in the first 12 h after oral and intramuscular administration was 38+/-6% and 34+/-5%, respectively.
Delbeke
F T
FT
Vakgroep Farmacologie, Farmacie en Toxicologie, Faculteit Diergeneeskunde, Universiteit Gent, Merelbeke, Belgium.
Baert
K
K
De Backer
P
P
D000042:Absorption; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003080:Cold Temperature; D004355:Drug Stability; D005260:Female; D006736:Horses / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D007668:Kidney / Q000378:metabolism; D008027:Light; D008832:Microchemistry; D011422:Propionates / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid