Polymyositis associated with asymptomatic primary biliary cirrhosis.
We here describe a case of polymyositis associated with asymptomatic primary biliary cirrhosis and a high titer of antimitochondrial antibodies. The patient had remarkable multiorgan engagement: polyarthritis, pericarditis, pleuritis and tachyarrythmia. Atypical changes, suggestive of mitochondrial damage, were observed in a muscle biopsy specimen. Under treatment with azathioprine and steroids, the disease had a favourable outcome.
Bondeson
J
J
Department of Rheumatology, Malmö University Hospital, Sweden.
Veress
B
B
Lindroth
Y
Y
Lindgren
S
S
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000906:Antibodies / Q000032:analysis; D001379:Azathioprine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology; D009132:Muscles / Q000473:pathology; D017285:Polymyositis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000906:Antibodies; D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine