title: [An exceptional variety of medulloblastoma: melanotic medulloblastoma].
abstract: We report a new case of melanotic medulloblastoma of the vermis in a 3 1/2 year old boy. This tumor showed a typical histological appearance with pseudoepithelial pigmented structures immunoreactive for S100 protein and vimentin. The tumor did not recur after total surgical removal and post operative radiation. However, after a 10 year follow-up, imaging demonstrated that a second tumor occurred in the left cerebellar hemisphere, which, on histological examination, was a typical glioblastoma. Hypothesis concerning the histogenesis of the second tumor, as well as a causal association with radiation therapy and possible contribution of growth hormone therapy are discussed.
authors.affiliation: Laboratoire d'Anatomie Pathologique, Faculté de Médecine, Vandaeuvre-les-Nancy.
authors.forename: F
authors.initials: F
authors.lastname: Baylac
authors.forename: A
authors.initials: A
authors.lastname: Martinoli
authors.forename: B
authors.initials: B
authors.lastname: Marie
authors.forename: S
authors.initials: S
authors.lastname: Bracard
authors.forename: J C
authors.initials: JC
authors.lastname: Marchal
authors.forename: P
authors.initials: P
authors.lastname: Bey
authors.forename: D
authors.initials: D
authors.lastname: Sommelet
authors.forename: J
authors.initials: J
authors.lastname: Hassoun
authors.forename: F
authors.initials: F
authors.lastname: Plénat
mesh_terms: D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000378:metabolism / Q000473:pathology*; D008543:Melanins / Q000096:biosynthesis*
chemical_list: D008543:Melanins
vernacular_title: Une variété exceptionnelle de médulloblastome: le médulloblastome mélanotique.