Correlation between bioeffector characteristics of sphingolipids and the structure of their hydrophobic fragment.
The effect of the structure of the hydrocarbon sphingoid base chain (length, presence of double bonds, and steric configuration of functional groups) and the length of the fatty acid residue of a ceramide molecule on the bioregulatory activities of sphingoids and ceramides is reviewed. Particular emphasis is placed on the role of functional groups (OH- and NH2-) typical of the sphingoid chain.
Dyatlovitskaya
E V
EV
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. jgmol@ibch.siobc.ras.ru
D000818:Animals; D002518:Ceramides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D013107:Sphingolipids / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002518:Ceramides; D005227:Fatty Acids; D013107:Sphingolipids