title: Granulocytic ehrlichiosis in tick-immune guinea pigs.
abstract: We investigated whether Ixodes scapularis-mediated host immunity interrupts transmission of the agent of human granulocytic ehrlichiosis (aoHGE) to guinea pigs. Ticks infected with aoHGE readily transmitted aoHGE to tick-immune guinea pigs, despite incomplete tick engorgement and host attachment. Although tick immunity can prevent Lyme borreliosis, protection is not afforded against granulocytic ehrlichiosis.
authors.affiliation: Department of Internal Medicine, Yale University, New Haven, Connecticut 06520-8031, USA.
authors.forename: S
authors.initials: S
authors.lastname: Das
authors.forename: K
authors.initials: K
authors.lastname: Deponte
authors.forename: N L
authors.initials: NL
authors.lastname: Marcantonio
authors.forename: J W
authors.initials: JW
authors.lastname: Ijdo
authors.forename: E
authors.initials: E
authors.lastname: Hodzic
authors.forename: P
authors.initials: P
authors.lastname: Katavolos
authors.forename: S W
authors.initials: SW
authors.lastname: Barthold
authors.forename: S R
authors.initials: SR
authors.lastname: Telford
authors.forename: F S
authors.initials: FS
authors.lastname: Kantor
authors.forename: E
authors.initials: E
authors.lastname: Fikrig
mesh_terms: D000818:Animals; D016873:Ehrlichiosis / Q000517:prevention & control* / Q000635:transmission; D005260:Female; D006168:Guinea Pigs; D018922:HL-60 Cells; D006801:Humans; D015151:Immunoblotting; D018884:Ixodes / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D016513:Mice, SCID; D016133:Polymerase Chain Reaction