Homocysteinemia and endothelial damage after methionine load.
Homocysteinemia increased significantly after a methionine load of 50 mg/kg in patients with peripheral artery occlusive disease but this load was insufficient to increase circulating endothelial cell count as a marker of endothelial damage. Only after an increased load of 100 mg/kg methionine circulating endothelial cells also increased markedly confirming the results of a previous experimental study. These data indicate a threshold concentration of homocysteine in blood necessary to induce endothelial lesions.
Hladovec
J
J
4th Medical Clinic, Medical Faculty, Charles University, Prague, Czech Republic.
Sommerová
Z
Z
Písaríková
A
A
D001157:Arterial Occlusive Diseases / Q000378:metabolism / Q000473:pathology; D001772:Blood Cell Count; D001773:Blood Cells / Q000473:pathology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000293:injuries* / Q000473:pathology; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008715:Methionine / Q000008:administration & dosage*; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000378:metabolism / Q000473:pathology
D006710:Homocysteine; D008715:Methionine