Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition.
A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococcus neoformans but not some other Candida species or Aspergillus species. Therapeutic efficacy in a mouse model of systemic candidosis was attained following parenteral dosing.
Kinsman
O S
OS
Glaxo Wellcome Research and Development, Hertfordshire, UK.
Chalk
P A
PA
Jackson
H C
HC
Middleton
R F
RF
Shuttleworth
A
A
Rudd
B A
BA
Jones
C A
CA
Noble
H M
HM
Wildman
H G
HG
Dawson
M J
MJ
Stylli
C
C
Sidebottom
P J
PJ
Lamont
B
B
Lynn
S
S
Hayes
M V
MV
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005285:Fermentation; D051379:Mice; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry* / Q000145:classification; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; C111326:GR135402; D011083:Polycyclic Compounds; D011500:Protein Synthesis Inhibitors