A potential diagnostic application of magnetization transfer contrast: an in vitro NMR study of excised human thyroid tissues.
A series of freshly excised thyroid tissues was analysed using a nuclear magnetic resonance spectrometer and then subjected to routine histo-pathology examination. Whilst simple T1 values for normal tissue and goitre are not significantly different, the degree of intra-subject T1 and T1s variability is shown to be an indicator of benign thyroid disease. Using data collected from an inversion-recovery sequence performed with and without magnetization transfer, a magnetization transfer rate constant was calculated for each tissue sample. These data suggest that this parameter may provide in vivo discrimination between follicular cancer and follicular adenoma.
Callicott
C
C
Clinical Physics Group, Royal Hospitals NHS Trust, London, UK.
Goode
A W
AW
D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D055592:Biophysical Phenomena; D001703:Biophysics; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006042:Goiter / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D013959:Thyroid Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D013961:Thyroid Gland / Q000378:metabolism* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology