Sexually dimorphic MK801-induced c-fos in the rat hypothalamic paraventricular nucleus.
MK801 induces Fos-like immunoreactivity (FLI) in the paraventricular nucleus (PVN) in a sex, age, hormone and dosage dependent manner. MK801 (1.0 mg/kg) elicited greater behavioural disruption, but less FLI in the PVN of cycling and lactating female rats, compared to like-treated males. Results from gonadectomized rats with or without acute steroid replacement resembled those seen in intact rats but sex differences were extinguished. At a lower dose (0.1 mg/kg), behavioural effects were diminished but females exhibited more behavioural disruption. At this dose however, more FLI was seen in the PVN of females compared to males, but only male-lactating female differences were significant. Taken together, the data suggest that the action of MK801 on the PVN is influenced by gonadal steroids.
Wintrip
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Department of Physiology and Biophysics, Dalhousie University, Faculty of Medicine, Halifax, NS, Canada.
Nance
D M
DM
Wilkinson
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M
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology; D001522:Behavior, Animal / Q000502:physiology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D007150:Immunohistochemistry; D007774:Lactation / Q000502:physiology; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology
D018931:Antineoplastic Agents, Hormonal; D018691:Excitatory Amino Acid Antagonists; D016760:Proto-Oncogene Proteins c-fos; D013739:Testosterone; D004958:Estradiol; D016291:Dizocilpine Maleate