title: Development of neurogenic pulmonary edema at different grades of intracranial pressure in cats.
abstract: Development of neurogenic pulmonary edema (NPE) subsequent to increased intracranial pressure (ICP) was evaluated in an experimental model in cats. Experiments were conducted in chloralose anaesthetised animals, either on spontaneous respiration or on intermittent positive pressure ventilation. Hemodynamic parameters i.e., mean arterial pressure (MAP) and heart rate (HR) were continuously monitored. Pulmonary artery/right ventricular systolic pressure was recorded in cats on spontaneous respiration. Increase in ICP for 180 minutes caused an increase in extravascular lung water (EVLW) content in both spontaneously breathing and artificially ventilated animals. In spontaneously breathing animals EVLW to blood free dry weight ratio (EVLW/BFDW) was 3.95 +/- 0.16 and 4.96 +/- 0.16 at ICP 40 and 80 mm Hg respectively while in animals on artificial ventilation, at 40, 60, 80 and 100 mm Hg ICP, it was 3.88 +/- 0.11, 4.09 +/- 0.10, 4.50 +/- 0.13 and 5.03 +/- 0.17 respectively. These values were significantly greater (P < 0.05) as compared to that in sham operated animals (3.43 +/- 0.10). This was accompanied by rise in MAP, HR and pulmonary artery pressure. The study establishes the graded development of NPE, the severity of which is proportional to the levels of ICP.
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
authors.forename: Y K
authors.initials: YK
authors.lastname: Gupta
authors.forename: A
authors.initials: A
authors.lastname: Chugh
authors.forename: V
authors.initials: V
authors.lastname: Kacker
authors.forename: V S
authors.initials: VS
authors.lastname: Mehta
authors.forename: P N
authors.initials: PN
authors.lastname: Tandon
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D015633:Extravascular Lung Water / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D007276:Injections, Intraventricular; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D011654:Pulmonary Edema / Q000209:etiology* / Q000503:physiopathology*
chemical_list: D006454:Hemoglobins