title: Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice.
abstract: To evaluate the cognitive phenotype of the segmental trisomy 16 (Ts65Dn) mouse, a model of Down Syndrome (DS, trisomy 21), we assessed spatial working and reference memory using a 12-arm radial maze (RAM). Ts65Dn mice made a greater number of reference memory errors across trials compared to control mice. Both genotypes showed improvement across trials, although improvement was slower in Ts65Dn mice. Ts65Dn mice also made a greater number of working memory errors on the RAM, and in contrast to control mice, did not improve across trials, always performing at near-chance levels. These results provide evidence for both spatial working and reference memory deficits in Ts65Dn mice, characteristics of cognitive dysfunction.
authors.affiliation: Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA. demas@ren.psy.jhu.edu
authors.forename: G E
authors.initials: GE
authors.lastname: Demas
authors.forename: R J
authors.initials: RJ
authors.lastname: Nelson
authors.forename: B K
authors.initials: BK
authors.lastname: Krueger
authors.forename: P J
authors.initials: PJ
authors.lastname: Yarowsky
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000235:genetics* / Q000523:psychology; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000235:genetics* / Q000523:psychology; D051379:Mice; D008818:Mice, Neurologic Mutants; D013028:Space Perception / Q000502:physiology*; D014314:Trisomy / Q000235:genetics* / Q000503:physiopathology*