Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni.
Female mice treated with dehydroepiandrosterone sulfate early during infection were partially protected (P < 0.05-0.005) from Schistosoma mansoni infection. Hormone treatment did not modify parasite-specific cellular or humoral responses. Serum dehydroepiandrosterone sulfate levels and testosterone infection were negatively correlated, r = -0.621 and r = -0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate-treated female mice may be due to the known antischistosomular activity of testosterone.
Fallon
P G
PG
Department of Pathology, University of Cambridge, United Kingdom. pgf@mole.bio.cam.ac.uk
Richardson
E J
EJ
Jones
F M
FM
Dunne
D W
DW
D000818:Animals; D019314:Dehydroepiandrosterone Sulfate / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000188:drug therapy*
D019314:Dehydroepiandrosterone Sulfate