title: Severe hypotension associated with angiotensin-converting enzyme inhibition in anaesthesia.
abstract: Three cases of severe hypotension associated with the use of angiotensin-converting enzyme inhibitors (ACEIs) and intravenous administration of the synthetic colloid Gelofusin (Braun Medical Ltd) are presented. A possible mechanism of interaction between ACEIs and Gelofusin is discussed. All three patients were treated successfully.
authors.affiliation: Department of Anaesthesia and Immunology, Southmead Hospital, Westbury-on-Trym,, Bristol, United Kingdom.
authors.forename: C G
authors.initials: CG
authors.lastname: Powell
authors.forename: D J
authors.initials: DJ
authors.lastname: Unsworth
authors.forename: F K
authors.initials: FK
authors.lastname: McVey
mesh_terms: D000368:Aged; D000758:Anesthesia; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D001810:Blood Volume / Q000187:drug effects; D005260:Female; D005780:Gelatin / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology; D010952:Plasma Substitutes / Q000009:adverse effects*; D013386:Succinates / Q000009:adverse effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010952:Plasma Substitutes; D013386:Succinates; C060085:succinylated gelatin; D005780:Gelatin