title: In vitro antimycobacterial activity of 5-chloropyrazinamide.
abstract: 5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.
authors.affiliation: Veterans Affairs Medical Center, Syracuse, New York 13210, USA. CYNAMON.MICHAEL@SYRACUSE.VA.GOV
authors.forename: M H
authors.initials: MH
authors.lastname: Cynamon
authors.forename: R J
authors.initials: RJ
authors.lastname: Speirs
authors.forename: J T
authors.initials: JT
authors.lastname: Welch
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009163:Mycobacterium bovis / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011718:Pyrazinamide / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: C111084:5-chloropyrazinamide; C111083:5-chloropyrazinoic acid; D000995:Antitubercular Agents; D011718:Pyrazinamide