[Study of the efficacy of prostaglandins and prostacyclin in decrease of osmotic permeability of the frog urinary bladder].
Washout of autacoids using a repeated change of serosal Ringer solution of the frog urinary bladder was accompanied by a pronounced rise in the osmotic water permeability. A decrease in the osmotic water permeability was achieved by addition at the serosal Ringer solution of different eikosanoids at concentrations of 10(-10)-10(-6) M. According to efficiency of the recovery of the low osmotic water permeability, the substances studied showed the following order: prostaglandin E1 > prostaglandin > E2 > prostaglandin F2 alpha > (prostaglandin I2). The data obtained indicate a role of the endogenous prostaglandin production in maintaining of the low osmotic water permeability.
Shakhmatova
E I
EI
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg, Russia.
Prutskova
N P
NP
Natochin
Iu V
IuV
D000527:Alprostadil / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D015237:Dinoprost / Q000378:metabolism / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism / Q000494:pharmacology; D011464:Epoprostenol / Q000378:metabolism* / Q000494:pharmacology; D066298:In Vitro Techniques; D011453:Prostaglandins / Q000378:metabolism* / Q000494:pharmacology; D011896:Rana temporaria; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology; D019459:Urothelium / Q000187:drug effects / Q000378:metabolism; D014867:Water / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D011453:Prostaglandins; D014867:Water; D015237:Dinoprost; D011464:Epoprostenol; D000527:Alprostadil; D015232:Dinoprostone
Issledovanie éffektivnosti prostaglandinov i prostatsiklina v snizhenii osmoticheskoĭ pronitsaemosti mochevogo puzyria liagushki.