title: Use of mouse mammary tumour virus (MMTV)/neu transgenic mice to identify genes collaborating with the c-erbB-2 oncogene in mammary tumour development.
abstract: Mouse mammary tumour virus (MMTV)/neu transgenic mice develop clonal or oligoclonal mammary tumours stochastically. The pathology of these tumours is very similar to that of human breast tumours. Moreover, these mouse tumours metastasize in the lungs. We present evidence that this mouse model of human breast tumours can be instrumental in identifying novel genes of two distinct classes (activated oncogenes or tumour suppressor genes) which may collaborate with the c-erbB-2/neu transgenic oncogene.
authors.affiliation: Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Jolicoeur
authors.forename: L
authors.initials: L
authors.lastname: Bouchard
authors.forename: A
authors.initials: A
authors.lastname: Guimond
authors.forename: M
authors.initials: M
authors.lastname: Ste-Marie
authors.forename: Z
authors.initials: Z
authors.lastname: Hanna
authors.forename: A
authors.initials: A
authors.lastname: Dievart
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology / Q000821:virology; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases