Glomerular prostanoid production is modified by plasma samples of hypertensive and diabetic patients.
The autocrin-paracrin prostanoid system plays a major role in the enhancement or inhibition of renal tissue damage. Our hypothesis was that there might be circulating factors in the plasma with a capability to modify renal (glomerular) prostanoid synthesis. We measured the synthesis of prostacyclin 1-2 (PGI2) and thromboxan A-2 (TxA2) of isolated glomeruli, incubated in plasma samples obtained from hypertensive and diabetic (NIDDM) patients. It was found that these plasma samples decreased the renal PGI2/TxA2 ratio, mostly by decreasing glomerular PGI2 synthesis and, to a lesser extent, increasing the synthesis of TxA2. Our results demonstrate that circulating factors in hypertension and diabetes might play a role in renal damage seen in these conditions.
Székács
B
B
Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary. sb@sote.bel2.sote.hu
Vajó
Z
Z
Juhász
I
I
Vaslaki
L
L
Nagy
V
V
D000328:Adult; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003928:Diabetic Nephropathies / Q000209:etiology; D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D066298:In Vitro Techniques; D007668:Kidney / Q000293:injuries; D007674:Kidney Diseases / Q000209:etiology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011921:Rats, Inbred WKY; D013928:Thromboxane A2 / Q000096:biosynthesis
D011453:Prostaglandins; D000804:Angiotensin II; D001127:Arginine Vasopressin; D013928:Thromboxane A2; D011464:Epoprostenol; D001920:Bradykinin