title: Antigenic characteristic of the lipopolysaccharides of Coxiella burnetii isolates.
abstract: Lipopolysaccharides (LPSs) of 8 isolates of Coxiella burnetii from a variety of clinical and geographical sources could be divided into four groups based on molecular heterogeneity in silver-stained sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) profiles in the region of the 10 to 17 kDa. The lipopolysaccharide of group 1 was identified on isolates from acute Q fever patient, milk and tick. The three remaining groups were primarily found on isolates from human cases of chronic Q fever. These LPSs shared many antigenic epitopes, as determined by immunoblotting with mouse anti-C. burnetii antisera.
authors.affiliation: Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: To
authors.forename: A
authors.initials: A
authors.lastname: Hotta
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Fukushi
authors.forename: K
authors.initials: K
authors.lastname: Hirai
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial; D000940:Antigenic Variation; D002417:Cattle; D016997:Coxiella burnetii / Q000276:immunology* / Q000302:isolation & purification; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005843:Geography; D006041:Goats / Q000382:microbiology*; D006351:Heart Valves / Q000382:microbiology; D006801:Humans; D015151:Immunoblotting; D007564:Japan; D008070:Lipopolysaccharides / Q000032:analysis / Q000276:immunology*; D051379:Mice; D008892:Milk / Q000382:microbiology; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011778:Q Fever / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial; D008070:Lipopolysaccharides