title: Nuclear magnetic resonance spectral analysis and conformational properties of 11-benzoyl-9,9a,10,11-tetrahydro-4H-indolo[4,3-ab]carbazole.
abstract: The structure of 11-benzoyl-9,9a,10,11-tetrahydro-4H-indolo [4,3-ab] carbazole, a candidate molecule to possess significant antitumor or antimicrobial activity, was elucidated using a combination of one-dimensional and two-dimensional nuclear magnetic resonance (NMR) techniques. Its conformational properties were studied using a combination of two-dimensional NOESY spectroscopy and molecular modeling. Such information will be of aid to synthetic chemists who aim to develop derivatives of this structure. It may also provide information about the stereoelectronic requirements that govern their activities.
authors.affiliation: Institute of Organic and Pharmaceutical Chemistry, The National Hellenic Research Foundation, Athens, Greece.
authors.forename: T
authors.initials: T
authors.lastname: Mavromoustakos
authors.forename: I K
authors.initials: IK
authors.lastname: Stamos
authors.forename: C
authors.initials: C
authors.lastname: Kamoutsis
authors.forename: E
authors.initials: E
authors.lastname: Theodoropoulou
authors.forename: M
authors.initials: M
authors.lastname: Zervou
authors.forename: E
authors.initials: E
authors.lastname: Humpfer
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D002227:Carbazoles / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: C111997:11-benzoyl-9,9a,10,11-tetrahydro-4H-indolo(4,3-ab)carbazole; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D002227:Carbazoles; D007211:Indoles