The pathogenetic role of HLA-B27 in chronic arthritis.
Population and peptide specificity analyses and studies in transgenic rodents support a role of HLA-B27 as an antigen-presenting molecule in spondyloarthropathy. The interplay between HLA-B27 and arthritogenic bacteria on infected cells suggests that HLA-B27 might also influence disease by other mechanisms. Recent genetic advances promise the identification of additional susceptibility genes.
López de Castro
J A
JA
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Facultad de Ciencias, Spain. aldecastro@trasto.cbm.uam.es
D000818:Animals; D030801:Animals, Genetically Modified; D001168:Arthritis / Q000235:genetics* / Q000503:physiopathology*; D001424:Bacterial Infections / Q000276:immunology; D002908:Chronic Disease; D003545:Cysteine / Q000276:immunology; D015796:HLA-B27 Antigen / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D010455:Peptides / Q000276:immunology; D011110:Polymorphism, Genetic; D013122:Spinal Diseases / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000503:physiopathology; D013601:T-Lymphocytes / Q000276:immunology
D015796:HLA-B27 Antigen; D010455:Peptides; D003545:Cysteine