Trisomy 3 as the sole karyotypic change in a pediatric immature teratoma.
Cytogenetic analysis of short-term cultured cells from an immature ovarian teratoma of a 9-year-old girl disclosed an extra copy of chromosome 3 as the sole clonal abnormality. The fact that trisomy 3 was previously reported as the only karyotypic change in two ovarian germ-cell tumors--one teratoma NOS and one immature teratoma--suggests that gain of chromosome 3 constitutes an early and pathogenetically important change in a subset of female germ-cell tumors.
Mertens
F
F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Kullendorff
C M
CM
Hjorth
L
L
Alumets
J
J
Mandahl
N
N
D002648:Child; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D013724:Teratoma / Q000235:genetics*; D014314:Trisomy