Comparison of intrauterine insemination with timed intercourse in superovulated cycles with gonadotropins: a meta-analysis.
OBJECTIVE
To compare timed intercourse and IUI with the husband's sperm in patients with unexplained infertility who are undergoing superovulation with gonadotropins.


METHODS
Meta-analysis. All published reports of randomized, prospective studies with an English-language abstract extracted from MEDLINE were analyzed. A crossover search was done from the papers obtained.


METHODS
Academic center.


METHODS
Couples with unexplained infertility.


METHODS
Meta-analysis of studies evaluating patients superovulated with gonadotropins and randomized for timed intercourse or IUI.


METHODS
Pregnancy rates (PRs) were obtained. The common odds ratio (OR) and 95% confidence intervals (95% CI) were calculated.


RESULTS
There were 49 pregnancies in 431 cycles of timed intercourse (11.37%), whereas there were 110 pregnancies in 549 cycles of IUI (20.04%). The PRs for IUI were significantly increased compared with those for timed intercourse in superovulation cycles (common OR = 1.84; 95% CI = 1.30-2.62).


CONCLUSIONS
On the basis of the meta-analysis of 980 cycles in randomized and prospective studies, a patient's chances of becoming pregnant are greater with IUI with her husband's sperm than with timed intercourse in cycles superovulated with gonadotropins.
Zeyneloglu
H B
HB
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.
Arici
A
A
Olive
D L
DL
Duleba
A J
AJ
D000328:Adult; D003075:Coitus; D005260:Female; D006062:Gonadotropins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007317:Insemination, Artificial, Homologous; D016239:MEDLINE; D008297:Male; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D013480:Superovulation; D013997:Time Factors
D006062:Gonadotropins