title: Destruxin-A4 chlorohydrin, a novel destruxin from fungus OS-F68576: isolation, structure determination, and biological activity as an inducer of erythropoietin.
abstract: In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2-2 microM.
authors.affiliation: MYCOsearch, OSI Pharmaceuticals, Durham, North Carolina 27707, USA.
authors.forename: P
authors.initials: P
authors.lastname: Cai
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: B
authors.initials: B
authors.lastname: Katz
authors.forename: C
authors.initials: C
authors.lastname: Pearce
authors.forename: D
authors.initials: D
authors.lastname: Venables
authors.forename: D
authors.initials: D
authors.lastname: Houck
mesh_terms: D002460:Cell Line; D047630:Depsipeptides; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000378:metabolism; D004921:Erythropoietin / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000737:chemistry*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D011994:Recombinant Proteins; D013268:Stimulation, Chemical
chemical_list: D047630:Depsipeptides; D010456:Peptides, Cyclic; D011994:Recombinant Proteins; C111695:destruxin A4 chlorohydrin; D004921:Erythropoietin