Electroanalytical study of nifedipine using activated glassy carbon electrode.
The electrochemical properties of nifedipine have been investigated in aqueous solution by linear sweep and cyclic voltammetry. The method is based both on the reduction and on the oxidation of the drug at a glassy carbon electrode activated by applying a new pre-treatment. The voltammograms of nifedipine on pH, concentration and scan rate have been carefully examined. Both the electroreduction and electrooxidation of nifedipine allow its determination at pH 1.5 in the concentration range of 2 x 10(-5)-6 x 10(-4) M and 8 x 10(-5)-1 x 10(-3) M, respectively. The method has been applied to commercial samples (tablets and capsules).
Sentürk
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Z
Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Turkey.
Ozkan
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SA
Ozkan
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Y
D002121:Calcium Channel Blockers / Q000032:analysis*; D002244:Carbon; D004563:Electrochemistry / Q000295:instrumentation*; D004566:Electrodes; D009543:Nifedipine / Q000032:analysis*; D010084:Oxidation-Reduction; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D002121:Calcium Channel Blockers; D002244:Carbon; D009543:Nifedipine