Analysis of diversity of mutations in the mecI gene and mecA promoter/operator region of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
Genomic diversity of mutation in the mecI gene or mecA promoter/operator region was analyzed for clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE). In most MRSA strains, a single base substitution was detected in either the mecI (three different positions) or the mecA promoter (two different positions), while a 28-base deletion in mecI was found in one strain. In contrast, no mutation was detected in these gene sequences of MRSE strains.
Kobayashi
N
N
Department of Hygiene, Sapporo Medical University School of Medicine, Japan. nkobayas@sapmed.ac.jp
Taniguchi
K
K
Urasawa
S
S
D001426:Bacterial Proteins; D001483:Base Sequence; D017353:Gene Deletion; D005798:Genes, Bacterial / Q000235:genetics*; D014644:Genetic Variation; D016106:Methicillin Resistance / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D017354:Point Mutation; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D013211:Staphylococcus aureus / Q000235:genetics*; D013212:Staphylococcus epidermidis / Q000235:genetics*
D001426:Bacterial Proteins; C101640:MecI protein, Staphylococcus; D012097:Repressor Proteins