Aspirin for prevention of myocardial infarction. A double-edged sword.
BACKGROUND
The use of low dose aspirin is associated with upper gastrointestinal bleeding, especially in the elderly. Anemia is one of the risk factors of acute myocardial infarction especially in patients with ischemic heart disease.


RESULTS
We present a series of fifteen patients treated with low dose aspirin for secondary prevention of ischemic heart disease who had upper GI bleeding and were admitted to our hospital because of unstable angina or myocardial infarction. Nine patients had acute myocardial infarction and six patients had unstable angina. The mean age of the patient was 72 +/- 9 years. Only two patients had a previous history of duodenal ulcer before their admission. The duration of aspirin therapy ranged from a few days to more than a year. Weakness, abdominal pain and melena were present in most of the patients between 2-7 days before the appearance of chest pain, and syncope was the chief complaint in 5 patients.


CONCLUSIONS
We conclude that aspirin which is given to patients in order to prevent myocardial infarction might cause myocardial infarction as a sequella of upper gastrointestinal bleeding. Lack of patient education was the primary cause of the delayed diagnosis of this complication. Instruction of patients treated by aspirin to seek medical advise because of symptoms of gastrointestinal bleeding could prevent acute myocardial infarction in patients treated by aspirin who have upper gastrointestinal bleeding.
Bar-Dayan
Y
Y
Department of Medicine 'B', Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
Levy
Y
Y
Amital
H
H
Shoenfeld
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology; D000789:Angina, Unstable / Q000209:etiology; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000517:prevention & control*; D012307:Risk Factors
D001241:Aspirin