title: Carotid body paraganglioma metastatic to bone: report of two cases.
abstract: Two patients with carotid body paraganglioma developed bone metastases 3 and 6 years respectively after surgical excision of the primary tumors. Plain radiographs showed ill-defined metastatic lesions. Scintigram using radiolabeled metaiodobenzylguanidine, an analogue of noradrenaline that is taken up by neurosecretary granules, showed an abnormal accumulation in the corresponding metastatic lesion. Histologically, nests of epithelioid cells with clear cytoplasm and pyknotic nuclei and abundant collagen fibers were observed within destroyed trabeculae. Treatment including external radiation and surgery provided pain relief and early local disease control.
authors.affiliation: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kawai
authors.forename: J H
authors.initials: JH
authors.lastname: Healey
authors.forename: S C
authors.initials: SC
authors.lastname: Wilson
authors.forename: A G
authors.initials: AG
authors.lastname: Huvos
authors.forename: S D
authors.initials: SD
authors.lastname: Yeh
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D002345:Carotid Body Tumor / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged