Effect of high-dose fentanyl on renal function in dogs.
Our objective was to determine the effects of high-dose fentanyl on canine renal function (RF). We anesthetized with sodium pentobarbital (SP) 16 dogs, randomly divided into 2 groups: in G1, SP was given alone, and in G2, combined with 0.05 mg.kg-1 fentanyl. All animals were ventilated artificially and had catheterized left and right femoral veins and left femoral artery for fluid infusion, drug administration, blood collection, and hemodynamic measurement. Urine was collected throughout the experiment. Attributes of RF were studied. SP did not alter RF, which was significantly altered by fentanyl. In G2, slower heart rates, mean arterial pressure, creatinine clearance, urinary output, osmolar clearance and fractional excretion of sodium and potassium were observed. G1 had a behavior attributed to extracellular volume expansion and no RF alterations. In G2, we observed significant decreases in RF due to opioid-induced hemodynamic changes, not discarding the possible action of aldosterone.
Castiglia
Y M
YM
Departamento de Anestesiologia da Faculdade de Medicina de Botucatu-UNESP-São Paulo, Brazil.
Braz
J R
JR
Vianna
P T
PT
Lemonica
L
L
Vane
L A
LA
D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005283:Fentanyl / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D013997:Time Factors
D000759:Adjuvants, Anesthesia; D006993:Hypnotics and Sedatives; D010424:Pentobarbital; D005283:Fentanyl