title: Effects of acute iron overload on Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss).
abstract: Distribution of radioiron to various tissues after intraperitoneal injections was examined in Atlantic salmon and rainbow trout. Liver and spleen were found to be the major iron storage tissues. Injections of 1 or 5 mg iron as ferric ammonium citrate led to a fall in hemoglobin levels in both species after 2 d. Hemoglobin levels returned to normal levels in rainbow trout after 8 d, but Atlantic salmon had not recovered, and Hb levels fell below 3 g/100 mL. In both species, the fall in Hb was associated with a raise in iron levels in spleen and liver, suggesting damage to erythrocytes. Atlantic salmon liver ferritin showed a two- to threefold increase, while rainbow trout showed a sixfold increase, and a more rapid response. The toxic effect of iron in fish appears to be different from the effect in other vertebrates.
authors.affiliation: Akvaforsk, Institute of Aquaculture Research, As, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Standal
authors.forename: K A
authors.initials: KA
authors.lastname: Rørvik
authors.forename: H
authors.initials: H
authors.lastname: Lien
authors.forename: O
authors.initials: O
authors.lastname: Andersen
mesh_terms: D000818:Animals; D005290:Ferric Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005293:Ferritins / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis; D017686:Oncorhynchus mykiss; D012474:Salmon; D014018:Tissue Distribution
chemical_list: D005290:Ferric Compounds; D006454:Hemoglobins; D005293:Ferritins