title: High throughput analysis and purification in support of automated parallel synthesis.
abstract: Rapid reverse-phase analytical and preparative HPLC methods have been developed for application to parallel synthesis libraries. Gradient methods, short columns, and high flow rates allow analysis of over 300 compounds per day on a single system, or purification of up to 200 compounds per day on a single preparative system. Hardware and software modifications allow continuous unattended use for maximum efficiency and throughput.
authors.affiliation: Combinatorial Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
authors.forename: H N
authors.initials: HN
authors.lastname: Weller
authors.forename: M G
authors.initials: MG
authors.lastname: Young
authors.forename: S J
authors.initials: SJ
authors.lastname: Michalczyk
authors.forename: G H
authors.initials: GH
authors.lastname: Reitnauer
authors.forename: R S
authors.initials: RS
authors.lastname: Cooley
authors.forename: P C
authors.initials: PC
authors.lastname: Rahn
authors.forename: D J
authors.initials: DJ
authors.lastname: Loyd
authors.forename: D
authors.initials: D
authors.lastname: Fiore
authors.forename: S J
authors.initials: SJ
authors.lastname: Fischman
mesh_terms: D001331:Automation; D001671:Biochemistry / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D012984:Software