Proliferation of C3H x CBA hybrid lymphocytes in the spleens of irradiated CBA mice: inhibition of this phenomenon by pretreatment of the hosts with C3H x CBA spleen cells.
Lymphocytes from C3H x CBA hybrid mice proliferate intensely in the spleens of irradiated CBA mice. Pretreatment of the CBA hosts with C3H x CBA spleen cells, known to specifically reduce the T-cell reactivity of the hosts against the strongly stimulatory Mls-antigen determined by the C3H-genome, abolished the capacity of the host to promote proliferation of C3H x CBA lymphocytes. In contrast, proliferation of C3H x CBA bone marrow cells, as measured by splenic 59Fe incorporation, was unaffected by such pretreatment. By examining the capacity of spleen cell populations of (C3H x CBA) x CBA back-cross mice to inhibit lymphocyte proliferation, as described above, and to express the C3H-determined Mls-antigen, it was concluded that these two traits are associated.
Lilliehöök
B
B
Department of Tumour Biology, Karolinska Institute, Stockholm, Sweden.
Blomgren
H
H
D000818:Animals; D002455:Cell Division; D004920:Erythropoiesis; D005260:Female; D006579:Heterozygote; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D016747:Minor Lymphocyte Stimulatory Antigens / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D014916:Whole-Body Irradiation
D016747:Minor Lymphocyte Stimulatory Antigens