Hyponatremic seizure in a child using desmopressin for nocturnal enuresis.
BACKGROUND
Intranasal desmopressin has been used extensively to treat primary nocturnal enuresis. While it has proven to be a safe, effective agent for many who are affected by this condition, the potential for complications exists.


OBJECTIVE
To report a case of severe hyponatremia associated with a generalized tonic-clonic seizure in a 10-year-old boy who had been receiving intranasal desmopressin nightly for nocturnal enuresis and to briefly review therapeutic options for nocturnal enuresis; and to present the role of desmopressin.


METHODS
Georgetown University Medical Center, Washington, DC.


METHODS
Fluid restriction and intravenous isotonic saline solution with 5% dextrose was administered to raise the serum sodium level.


RESULTS
Prevention of further seizures with normalization of serum sodium levels without any obvious neurological sequelae.


CONCLUSIONS
This case illustrates the importance of weighing the benefits and risks of intranasal desmopressin therapy.
Donoghue
M B
MB
Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA.
Latimer
M E
ME
Pillsbury
H L
HL
Hertzog
J H
JH
D002648:Child; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects* / Q000627:therapeutic use; D004775:Enuresis / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000150:complications; D008297:Male; D012076:Renal Agents / Q000009:adverse effects* / Q000627:therapeutic use
D012076:Renal Agents; D003894:Deamino Arginine Vasopressin