The NMDA receptor participates in respiration-related mitral cell synchrony.
The N-methyl-D-aspartate (NMDA)-type glutamate receptor participates in the excitation of olfactory bulb mitral cells and is important in granule-cell-mediated feedback-inhibition. In the present study, extracellular unit recordings were made in vivo to demonstrate that the firing rates of mitral cells are not affected by peripheral administration of the non-competitive NMDA receptor antagonist MK-801. However, while over 50% of odor-driven mitral cell activity is normally correlated with the respiratory cycle, only about 10% of mitral cell activity is correlated with the respiratory cycle 30 min after MK-801 administration. Thus, the NMDA receptor is a participant in normal respiration-related mitral cell activity and may have an important role in the formation of bulb oscillations that encode olfactory information. Furthermore, the NMDA receptor is in a position to mediate activity-dependent changes in the bulb that rely on synchronous activity.
Philpot
B D
BD
Department of Psychology, University of Virginia, Charlottesville 22903, USA.
Lyders
E M
EM
Brunjes
P C
PC
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology*; D019069:Cell Respiration / Q000187:drug effects / Q000502:physiology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D009830:Olfactory Bulb / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D009991:Oscillometry; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology*
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate