title: Granule cell dispersion is correlated with early epileptic events in human temporal lobe epilepsy.
abstract: Granule cell dispersion (GCD) into the dentate gyrus (DG) molecular layer was observed in hippocampal specimens in 10 out of 22 cases of human non-lesional temporal lobe epilepsy (TLE) and was associated with hippocampal sclerosis (HS). The presence of GCD was significantly linked to events of epileptic nature arising during the first 4 years of life but not with the durations of epilepsy, nor the number of seizures. Dispersion could be induced by seizure-linked structural plasticity occurring during a specific early permissive period.
authors.affiliation: Laboratoire de Neurobiologie et Neuro-imagerie Expérimentales, Université de Bordeaux II, France.
authors.forename: D
authors.initials: D
authors.lastname: Lurton
authors.forename: B
authors.initials: B
authors.lastname: El Bahh
authors.forename: L
authors.initials: L
authors.lastname: Sundstrom
authors.forename: A
authors.initials: A
authors.lastname: Rougier
mesh_terms: D016923:Cell Death; D002648:Child; D018891:Dentate Gyrus / Q000473:pathology*; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000473:pathology*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D006801:Humans; D009474:Neurons / Q000473:pathology*; D018709:Statistics, Nonparametric; D013997:Time Factors