title: [Development of tumor selection based on pathological stage in clinically localized prostate carcinoma].
abstract: Four hundred and eighty-eight radical retropubic prostatectomies (RRP) were performed on clinically localized prostate cancer at one institution within 5 years (1992-1996). These were then analyzed regarding the migration of pathological tumor stages towards more localized stages. Within the observation period, the annual rate of RRP increased by 81% from 69 to 125 cases. The authors noted a decline in the occurrence of advanced tumor stages (65.0% to 39.2%) and small cancers (< 0.5 cc: 7.2% to 1.6%) and an increase in pathological T2 tumors (30.4% to 55.2%). The rate of positive surgical margins declined from 34.7% to 12.8% (for all pathological stages). These data confirm trends which were observed in the USA with increasing detection and treatment of localized prostate cancer.
authors.affiliation: Urologische Universitätsklinik Hamburg-Eppendorf.
authors.forename: J
authors.initials: J
authors.lastname: Noldus
authors.forename: M
authors.initials: M
authors.lastname: Graefen
authors.forename: P
authors.initials: P
authors.lastname: Hammerer
authors.forename: R P
authors.initials: RP
authors.lastname: Henke
authors.forename: H
authors.initials: H
authors.lastname: Huland
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006801:Humans; D008297:Male; D008403:Mass Screening; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000517:prevention & control / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen