title: Structure and function in the nucleus.
abstract: Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.
authors.affiliation: Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland, UK. a.i.lamond@dundee.ac.uk
authors.forename: A I
authors.initials: AI
authors.lastname: Lamond
authors.forename: W C
authors.initials: WC
authors.lastname: Earnshaw
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000502:physiology / Q000648:ultrastructure; D002467:Cell Nucleus / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure*; D002843:Chromatin / Q000502:physiology; D002875:Chromosomes / Q000502:physiology; D029721:Drosophila Proteins; D022041:Euchromatin; D005786:Gene Expression Regulation; D006570:Heterochromatin / Q000502:physiology; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry / Q000502:physiology; D007399:Interphase; D009363:Neoplasm Proteins / Q000737:chemistry / Q000502:physiology; D009687:Nuclear Proteins; D063150:Polycomb Repressive Complex 1; D063146:Polycomb-Group Proteins; D000071156:Promyelocytic Leukemia Protein; D012097:Repressor Proteins / Q000737:chemistry / Q000502:physiology; D017411:Ribonucleoproteins, Small Nuclear / Q000032:analysis / Q000502:physiology; D014157:Transcription Factors / Q000737:chemistry / Q000502:physiology; D025521:Tumor Suppressor Proteins
chemical_list: D002843:Chromatin; D029721:Drosophila Proteins; D022041:Euchromatin; D006570:Heterochromatin; D019476:Insect Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; C066770:Pc protein, Drosophila; D063146:Polycomb-Group Proteins; D000071156:Promyelocytic Leukemia Protein; D012097:Repressor Proteins; D017411:Ribonucleoproteins, Small Nuclear; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C070576:PML protein, human; D063150:Polycomb Repressive Complex 1