Regulation of equine infectious anemia virus expression.
Equine infectious anemia virus (EIAV) is an ungulate lentivirus that is related to human immunodeficiency virus (HIV). Much of the understanding of lentiviral gene regulation comes from studies using HIV. HIV studies have provided insights into molecular regulation of EIAV expression; however, much of the regulation of EIAV expression stands in stark contrast to that of HIV. This review provides an overview of the current state of knowledge of EIAV regulation by comparing and contrasting EIAV gene regulation to HIV. The role of EIAV gene regulation is discussed in relation to EIAV pathogenesis.
Maury
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Department of Microbiology, University of South Dakota School of Medicine, Vermillion 57069, USA. wmaury@sundance.usd.edu
D000818:Animals; D001483:Base Sequence; D002353:Carrier State / Q000821:virology; D016384:Consensus Sequence; D004742:Enhancer Elements, Genetic; D004859:Equine Infectious Anemia / Q000821:virology*; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D006678:HIV / Q000502:physiology; D006736:Horses; D006801:Humans; D004860:Infectious Anemia Virus, Equine / Q000235:genetics / Q000502:physiology*; D008264:Macrophages / Q000821:virology; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D014158:Transcription, Genetic