Alzheimer-associated presenilin-1 gene is induced in gerbil hippocampus after transient ischemia.
To investigate the biological roles of the presenilin-1 (PS-1) gene after neuronal injury, the changes of PS-1 mRNA expression in the gerbil hippocampus after transient ischemia were examined. From 1 day to 3 day-reperfusion after 5 min-ischemia, PS-1 mRNA was induced in the hippocampus compared with the sham-operated control. The cells which induced the PS-1 genes were neurons of CA3 and dentate gyrus, the region relatively resistant to ischemic stress. These findings suggest that the induction of PS-1 genes may be associated with some responses of neurons damaged by transient ischemia.
Tanimukai
H
H
Department of Neuropsychiatry, Osaka University Medical School, Osaka 565, Japan.
Imaizumi
K
K
Kudo
T
T
Katayama
T
T
Tsuda
M
M
Takagi
T
T
Tohyama
M
M
Takeda
M
M
D000544:Alzheimer Disease / Q000235:genetics*; D000818:Animals; D015152:Blotting, Northern; D005849:Gerbillinae; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000032:analysis; D006624:Hippocampus / Q000098:blood supply / Q000378:metabolism*; D017403:In Situ Hybridization; D002546:Ischemic Attack, Transient / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D053764:Presenilin-1; D015424:Reperfusion
D008565:Membrane Proteins; D053764:Presenilin-1; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases