The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate.
Phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is a membrane phospholipid found in all eukaryotic cells which regulates many important cellular processes, including organization of the cytoskeleton, vesicular trafficking and platelet activation. PtdIns 4,5-P2 can either act as a substrate for lipid kinases and phosphatases, or directly interact with proteins. Recent work has focused on the characterization of the enzymes that regulate PtdIns 4,5-P2 levels in the cell. The discovery of proteins whose activities are modified by interaction with PtdIns 4,5-P2 has helped to redefine the role of this lipid in cell biology.
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Boston Biomedical Research Institute, MA 02114, USA.
D019870:1-Phosphatidylinositol 4-Kinase / Q000502:physiology; D000818:Animals; D002468:Cell Physiological Phenomena; D003599:Cytoskeleton / Q000201:enzymology / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000096:biosynthesis* / Q000502:physiology*
D019269:Phosphatidylinositol 4,5-Diphosphate; D019870:1-Phosphatidylinositol 4-Kinase