Distribution of cerebellar cortical lesions in multiple system atrophy: a topographic neuropathological study of three autopsy cases in Japan.
We investigated neuropathologically the distribution of the cerebellar cortical lesions in three Japanese autopsy cases of multiple system atrophy (MSA) using hemisphere specimens. The lesions were classified as mild, moderate or severe. The distribution of cerebellar cortical lesions in all three cases were uniform: the cerebellar cortical lesions were more conspicuous in the vermis than in the hemisphere. These neuropathological findings differ from the established theory that cerebellar lesions of MSA are more pronounced in the hemisphere than in the vermis. The degree of cerebellar cortical lesions in our cases increased in relation to the duration of the disease. Our pathological data may contribute to the morphological differential diagnosis in various neurodegenerative disorders including late cortical cerebellar atrophy. Our neuropathological findings may also make a contribution to the neuroradiological progress in the differential diagnosis of spinocerebellar disease.
Tsuchiya
K
K
Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Matsuzawa Hospital, and Tokyo Medical College, Japan.
Watabiki
S
S
Sano
M
M
Iobe
H
H
Shiotsu
H
H
Taki
K
K
Hashimoto
K
K
D001931:Brain Mapping; D002525:Cerebellar Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000145:classification / Q000473:pathology*; D011689:Purkinje Cells / Q000473:pathology; D012791:Shy-Drager Syndrome / Q000473:pathology