title: Changes in antibody titres against Leishmania infantum in naturally infected dogs in southern Spain.
abstract: Monthly serological follow-up of the antibody titres against Leishmania infantum in hunting dogs in rural southern Spain was carried out during the transmission period (from April to October in 1996). Titres > or = 160 were regarded as indicating disease, while lower positive tires were also recorded as 'seropositive'. Over this period, a significant (p < 0.05) increase in the percentage of dogs with a titre > or = 160 was observed; from 12.6% in April to 19.2% in October. The same pattern was observed with the seropositives (titre > or = 20) which increased from 36.3% in April to 55.6% in October. Of seronegatives in April, 60% were still negative in October whereas 22% had a titre of 20-40 and 18% had a titre > or = 80. Similarly, 68% of those with a titre > or = 80 in April still had a titre in this range in October, 25% of the titre had decreased to 20-40 and in 7% to a zero titre. The most noteworthy is that 25% of animals reached titres of > or = 80 and decreased to zero or 20 more than once. Parallel to this study, another survey was conducted on dogs from Granada city centre. The seroprevalences (titres > or = 160) at the start and the end of the transmission period were 1.7 and 3.7% respectively and the seropositively values were 12 and 11% respectively.
authors.affiliation: Dpt. Parasitologia, Fac. Farmacia, Granada, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Acedo-Sánchez
authors.forename: F
authors.initials: F
authors.lastname: Morillas-Márquez
authors.forename: M C
authors.initials: MC
authors.lastname: Sanchíz-Marín
authors.forename: J
authors.initials: J
authors.lastname: Martín-Sánchez
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D004283:Dog Diseases; D004285:Dogs; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D015995:Prevalence; D012423:Rural Health; D012621:Seasons; D013030:Spain / Q000453:epidemiology; D014504:Urban Health
chemical_list: D000913:Antibodies, Protozoan