Obesity: progress through genetic manipulation.
Transgenic mice have been produced that either lack or overproduce neuroregulatory substances implicated in the control of food intake and body weight. Are such mice useful models for understanding the underlying etiology of obesity in humans?
Levine
A S
AS
Minnesota Obesity Center, VA Medical Center, 1 Veterans Drive, Minneapolis, Minnesota 55417, USA.
Billington
C J
CJ
D000818:Animals; D001921:Brain / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D020738:Leptin; D051379:Mice; D018345:Mice, Knockout; D008820:Mice, Obese; D008822:Mice, Transgenic; D009154:Mutation; D018377:Neurotransmitter Agents / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011506:Proteins / Q000235:genetics
D020738:Leptin; D018377:Neurotransmitter Agents; D011506:Proteins