Mechanisms of secretion of toxic organic anions in mammalian kidneys.
This short review considers the mechanisms of organic anion secretion in renal proximal tubules. Particular attention is given to the energy coupling of p-aminohippurate transport to inorganic anion gradients generated across both basolateral and brush-border membranes. The coupling is considered to be a consequence of the combined operation of the co-transport and anion-exchange mechanisms. A possible coexistence of several organic anion pathways with overlapping substrate specificity and/or energetic dependence of the total ion gradient are suggested. The problem of identification of transporters involved in organic anion secretion is discussed.
Orlov YuN
St. Petersburg Institute of Nuclear Physics, Russian Academy of Sciences, Russia. orlov@bird.macro.ru
D000818:Animals; D027321:Anion Transport Proteins; D000838:Anions / Q000378:metabolism*; D001692:Biological Transport; D002352:Carrier Proteins / Q000502:physiology; D006801:Humans; D016623:Ion Pumps / Q000502:physiology*; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008322:Mammals; D014118:Toxins, Biological / Q000378:metabolism*
D027321:Anion Transport Proteins; D000838:Anions; D002352:Carrier Proteins; D016623:Ion Pumps; D014118:Toxins, Biological