Venous dysfunction and the change of blood viscosity during head-up tilt.
The precise stimulus that induces vasovagal syncope is still unclear. We have previously demonstrated that the peripheral distribution of blood volume (venous pooling) is a strong predictor of tilt induced vasovagal reaction. We hypothesized that an increase in venous pooling during tilt accentuates the measured increase in blood viscosity. This hypothesis is based on the previously demonstrated increase in venous pressure and subsequent increase in transcapillary fluid transudation during tilt. The increased blood viscosity, in turn, increases vascular shear rate, which may alter the vasoconstrictive and other cardiovascular responses to decreased preload. We measured blood viscosity (supine and tilt) in 56 patients with a history of orthostatic intolerance (37 with venous pooling [VP] and 19 without venous pooling [non-VP]). VP and non-VP were separated into subgroups based on blood pressure and heart rate response to tilt. There was a positive correlation between blood viscosity and plasma aldosterone in the supine. In the group as a whole, neither supine blood viscosity nor its increase during tilt differed between VP and non-VP. However, the tilt induced increase of blood viscosity was significant only in patients with tilt provoked tachycardia plus normal blood pressure response in VP group. We suggest that the increase of blood viscosity in this group led to the normal blood pressure response. The positive correlation between supine blood viscosity and supine plasma aldosterone indicates that the normal blood pressure response in this group possibly was via stimulation of the renin-angiotensin-aldosterone system.
Yamanouchi
Y
Y
Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA.
Jaalouk
S
S
Shehadeh
A A
AA
Fouad-Tarazi
F M
FM
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure; D001809:Blood Viscosity; D002395:Catecholamines / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture; D012083:Renin / Q000097:blood; D019462:Syncope, Vasovagal / Q000097:blood* / Q000209:etiology; D014655:Vascular Resistance; D014680:Veins; D014690:Venous Pressure
D002395:Catecholamines; D000450:Aldosterone; D012083:Renin