title: Autoimmune (Hashimoto's) thyroiditis associated with Crohn's disease.
abstract: We report the occurrence of autoimmune (Hashimoto's) thyroiditis in three patients with Crohn's disease. Previously, thyroid disease has been described only in association with ulcerative colitis. We review the pertinent literature on thyroid disease in inflammatory bowel disease (IBD) and suggest that this association supports the hypothesis that autoimmunity is involved in the pathogenesis of IBD. Early diagnosis and treatment of thyroid dysfunction in patients with IBD is desirable because thyroid dysfunction worsens the symptoms and course of IBD.
authors.affiliation: Division of Gastroenterology, Brown University School of Medicine, Providence, Rhode Island, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Shah
authors.forename: M A
authors.initials: MA
authors.lastname: Peppercorn
authors.forename: J A
authors.initials: JA
authors.lastname: Pallotta
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D013972:Thyrotropin / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000378:metabolism
chemical_list: D001323:Autoantibodies; D013975:Thyroxine-Binding Proteins; D013972:Thyrotropin; D013954:Thyroglobulin