title: Comparison of isoflurane with sevoflurane for anesthesia induction and recovery in adult dogs.
abstract: OBJECTIVE
  To compare mask anesthesia induction and recovery characteristics between 2 inhalant anesthetic agents: isoflurane and sevoflurane.
  
  
  METHODS
  16 clinically normal, young adult Beagles.
  
  
  METHODS
  Using a cross-over design, dogs were randomly selected to receive sevoflurane or isoflurane via a face mask and a circle anesthetic system. Vaporizer setting concentrations were increased in stepwise, equal minimum alveolar concentrations (MAC) for each anesthetic until the vaporizer setting of 2.6% for isoflurane or 4.8% for sevoflurane (2 MAC) was reached. Concentration was kept constant until the dog had a negative tail clamp response and was intubated. End-tidal concentration was maintained at 1.8 to 2.0% or 3.3 to 3.8% for isoflurane or sevoflurane, respectively (1.4 to 1.6 MAC) for 30 minutes. Dogs were allowed to recover with only tail clamp stimulation until a positive response was obtained. Extubation was performed when a spontaneous swallow reflex was observed. Dogs were allowed to achieve sternal recumbency and stand unassisted without further stimulation.
  
  
  RESULTS
  Sevoflurane induction resulted in shorter time to loss of palpebral reflex, negative tail clamp response, and time to tracheal intubation, and was of better quality than isoflurane induction. Both anesthetics were associated with rapid and smooth recovery.
  
  
  CONCLUSIONS
  Sevoflurane mask induction is faster and of better quality, compared with isoflurane, in adult dogs. Recovery time and quality are comparable.
  
  
  CONCLUSIONS
  On the basis of these results, sevoflurane is a suitable inhalant anesthetic for mask induction and recovery in adult dogs and appears to have some advantages over isoflurane, including faster and smoother mask induction.
authors.affiliation: Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Johnson
authors.forename: E
authors.initials: E
authors.lastname: Striler
authors.forename: D C
authors.initials: DC
authors.lastname: Sawyer
authors.forename: D B
authors.initials: DB
authors.lastname: Brunson
mesh_terms: D000704:Analysis of Variance; D000769:Anesthesia, Inhalation / Q000379:methods / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D018592:Cross-Over Studies; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D012018:Reflex / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D000077149:Sevoflurane; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D010100:Oxygen