title: Overcoming the unfavourable entropic contribution of ligand binding with a macrocyclic inhibitor bound to penicillopepsin.
authors.affiliation: MRC Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, Canada.
authors.forename: M E
authors.initials: ME
authors.lastname: Fraser
authors.forename: J H
authors.initials: JH
authors.lastname: Meyer
authors.forename: P A
authors.initials: PA
authors.lastname: Bartlett
authors.forename: M N
authors.initials: MN
authors.lastname: James
mesh_terms: D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D008024:Ligands; D011480:Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D011480:Protease Inhibitors; C022325:aspartic proteinase A; D016282:Aspartic Acid Endopeptidases