Erythroid-specific transcription.
Over the past year, the range of research related to erythroid cell-specific transcription has expanded beyond isolation of its transcriptional players to studies that address more complex yet still fundamental questions: first, whether these factors form part of a larger protein-protein structure; second, how factor interactions with DNA affect the surrounding chromatin configuration; third, how this affects the mechanism of gene switching within the beta-like globin cluster; and finally, how these regulators are themselves transcriptionally controlled.
Bieker
J J
JJ
Mount Sinai School of Medicine, Brookdale Center for Molecular Biology, New York, NY 10029, USA.
D000818:Animals; D004912:Erythrocytes / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D014158:Transcription, Genetic