title: Optima: a windows-based program for computer-aided optimization of controlled-release dosage forms.
abstract: The purpose of this work was to develop a computer program that assists optimization of controlled-release devices, both visually and mathematically, using response surface methodology (RSM). A Windows-based computer program, Optima, which interactively implemented a number of subroutines for the optimization procedure, was developed. Optima is an integrated, user-friendly, and graphically oriented program for pharmaceutical dosage form optimization. Central composite design is implemented in the program. First- and second-order models containing up to five variables can be fitted to the data. The user can also choose between linear and exponential individual desirability functions, and use them to construct an overall desirability function that combines all the response variables in a single response. The program can predict the optimum levels of experimental variables, with respect to individual responses and/or the overall desirability. Optima has been successfully used in the development of sustained-release AZT-loaded microspheres. During the optimization process, three experimental variables were investigated and four responses were measured. The experimental design was a central composite design that was generated by the program. The response values were used by the program to calculate the individual desirability functions, which were then combined into an overall desirability function. The individual responses as well as the overall desirability function were optimized by fitting to a second-order polynomial equation. The response surfaces were generated and optimum levels of the experimental variables were predicted. The observed responses of the optimized formulation were very close to those predicted by Optima. The program proved to be a very useful, integrated tool for optimization of the controlled-release microspheres.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, University of Georgia, Athens 30602, USA. rlu@merc.rx.uga.edu
authors.forename: D R
authors.initials: DR
authors.lastname: Lu
authors.forename: K
authors.initials: K
authors.lastname: Abu-Izza
authors.forename: W
authors.initials: W
authors.lastname: Chen
mesh_terms: D003196:Computer Graphics; D003460:Crystallization; D004339:Drug Compounding / Q000379:methods*; D008863:Microspheres; D008962:Models, Theoretical; D018271:Signal Recognition Particle; D012984:Software; D013499:Surface Properties; D015215:Zidovudine / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D018271:Signal Recognition Particle; D015215:Zidovudine