The effects of sensory stimulation on REM sleep duration.
Previous experiments have demonstrated that auditory (AS) and/or somatosensory (SS) stimulation can increase the duration of REM sleep periods in rats, cats and humans. The objectives of this study were to determine whether repeated AS stimulation causes habituation to the stimulus and whether any additive effects could be obtained with the simultaneous application of AS and SS. Three experimental procedures were used in this study. In experiment 1, animals were recorded for 4 consecutive days with AS, followed by a post-stimulus session. In experiment 2, they were recorded for 24 hours with AS applied at each REM period, followed by a subsequent 24-hours-post-stimulus recording. In experiment 3, animals underwent AS, SS stimulation, or simultaneous application of both in a random fashion at each REM period. The results of all experiments confirm previous findings showing that auditory or somatosensory stimuli significantly increase REM sleep period duration. In addition, AS--applied with different presentations during REM and throughout the sleep-wake cycle--are capable of increasing REM duration regardless of the manner in which they were presented. However, the effects of the stimuli were not additive. It is worth noting that although REM duration increased, REM period frequency decreased, resulting in no net change of total REM sleep through time. Furthermore, no changes were observed in other sleep-wake variables. These experiments clearly demonstrate that repeated auditory stimulation does not cause habituation, and there are no evident side effects on the sleep-wake cycle. These results confirm that the mechanisms involved in REM generation and maintenance can be modulated by sensory modalities.
Vazquez
J
J
Depto. de Fisiología, Fac. de Medicina, Universidad Nacional Autónoma de México, México, D.F.
Merchant-Nancy
H
H
García
F
F
Drucker-Colín
R
R
D000818:Animals; D002415:Cats; D004558:Electric Stimulation / Q000295:instrumentation; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004576:Electromyography; D004585:Electrooculography; D005260:Female; D008297:Male; D009334:Neck Muscles / Q000294:innervation; D010294:Parietal Bone / Q000601:surgery; D012895:Sleep, REM / Q000502:physiology*; D013238:Stereotaxic Techniques; D013997:Time Factors