Effect of mangan-desferrioxamin in the prevention of peritoneal adhesions.
An experimental study was carried out using mangan-desferrioxamin chelate, an effective iron-chelating and free oxygen radical scavenging agent, to prevent post-operative peritoneal adhesions in 40 Wistar albino rats. The density of adhesions was evaluated and group scores obtained. The means score (2.5 +/- 0.87) for the group of rats treated with mangan-desferrioxamin was significantly different (P < 0.001) (95% confidence interval 0.6 to 1.6) from that of the control group(mean score 3.9 +/- 0.3). This favourable effect of mangan-desferrioxamin in the prevention of post-operative adhesions should encourage further research to determine the mechanisms of action.
Soybir
G
G
Experimental Research Center of Istanbul Taksim Hospital, Turkey.
Köksoy
F
F
Ekiz
F
F
Yalçin
O
O
Ozşeker
A
A
Cokneşeli
B
B
D000818:Animals; D003676:Deferoxamine / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D007813:Laparotomy; D008297:Male; D008345:Manganese / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000517:prevention & control
D016166:Free Radical Scavengers; D009942:Organometallic Compounds; C111813:mangan-desferrioxamin; D008345:Manganese; D003676:Deferoxamine