title: Calf vein compliance increases following bed rest after aortocoronary bypass surgery.
abstract: Early post-operative ambulation (< 3 days) is expected to decrease the risk of venous thrombosis, whereas late ambulation (> 7 days) increases the risk of orthostatic hypotension. The effect of post-operative bed rest on calf vein compliance was studied before (D - 1) and 7 days (D + 7) after aortocoronary bypass surgery in 50 patients (41 men and nine women, 65 +/- SD 10 years). Calf vein compliance was measured by strain gauge plethysmography and stepwise increases in thigh congestive pressure from 20 to 60 mmHg. Calf compliance [median (25 percentile-75 percentile)] increased significantly by 48% from D - 1 to D + 7 [0.044 (0.039-0.051) vs. 0.065 (0.048-0.083) ml (100 ml mmHg)-1, P < 0.001]. This increase was reflected as increased calf volume for the 50 mmHg [D-1 2.10 (1.75-2.65) vs. D + 7 2.60 (1.70-3.00) ml 100 ml-1, P < 0.01] and 60 mmHg [D - 1 2.50 (2.10-2.95) vs. D + 7 3.20 (2.30-4.00) ml 100 ml-1, P < 0.001] occlusion pressure levels. The associated pathologies (diabetes and arterial hypertension) and NYHA grades had no significant influence on the increase in compliance. Among the vasoactive therapeutic regimens, calcium channel blockers contributed significantly to the increased calf compliance, but only on D-1. The increase in venous compliance following aortocoronary bypass surgery is multifactorial but should be considered for prophylactic management of these patients.
authors.affiliation: Department of Physiology, University School of Medicine, Angers, France.
authors.forename: G
authors.initials: G
authors.lastname: Leftheriotis
authors.forename: M S
authors.initials: MS
authors.lastname: Legrand
authors.forename: P
authors.initials: P
authors.lastname: Abraham
authors.forename: J B
authors.initials: JB
authors.lastname: Kamuanga-Subayi
authors.forename: A
authors.initials: A
authors.lastname: Jardel
authors.forename: J L
authors.initials: JL
authors.lastname: Saumet
mesh_terms: D000368:Aged; D001510:Bed Rest / Q000009:adverse effects*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007866:Leg / Q000033:anatomy & histology / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D012039:Regional Blood Flow / Q000502:physiology; D018924:Vascular Capacitance / Q000502:physiology*; D014680:Veins / Q000502:physiology*