A mitogenic and hormonal signalling network regulate mammalian cell division commitment time.
A basic property of mammalian cells is to retain the mitogenically induced "commitment" to undergo DNA replication even in the absence of stimuli. Recent findings on PGF2 alpha and hormone-induced Swiss 3T3 cell multiplication, reveal that this crucial cell cycle event can be regulated by several signalling mechanisms.
Jimenez de Asua
L
L
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Buenos Aires, Argentina.
Goin
M
M
Ortiz
M
M
Gomez de Alzaga
M B
MB
D016475:3T3 Cells; D000527:Alprostadil / Q000494:pharmacology; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology*; D004261:DNA Replication; D003703:Demecolcine / Q000494:pharmacology; D015237:Dinoprost / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008322:Mammals; D051379:Mice; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D007328:Insulin; D015237:Dinoprost; D000527:Alprostadil; D003703:Demecolcine