title: [Polyneuropathy: diagnosis and management].
abstract: A polyneuropathy is characterized by a symmetrical distribution of sensory or motor abnormalities, more pronounced distally than proximally and usually more evident in the lower than in the upper limbs. Polyneuropathies may be classified on the basis of (a) clinical picture: acute/subacute/chronic, sensory/motor/autonomous, axonal degeneration/segmental demyelinization, and (b) cause: metabolic disorder, deficiency, infection, auto(dys)immunity, hereditary and toxic/iatrogenic polyneuropathy, with idiopathic polyneuropathy as the remaining group. Damaged nerves may recover as the result of spontaneous remyelinization and axonal regeneration. Treatment is particularly successful in immunomediated neuropathies. Withdrawal is often successful in intoxications and suppletion in deficiencies. Even if no treatment is possible, the diagnosis is important: the patient can be taught to accept his disease and the prognosis can be determined, in connection with possible handicaps.
authors.affiliation: Afd. Neurologie, Academisch Ziekenhuis, Utrecht.
authors.forename: N C
authors.initials: NC
authors.lastname: Notermans
authors.forename: P A
authors.initials: PA
authors.lastname: van Doorn
mesh_terms: D000465:Algorithms; D001327:Autoimmune Diseases / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000175:diagnosis; D005260:Female; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000175:diagnosis; D015417:Hereditary Sensory and Motor Neuropathy / Q000175:diagnosis; D006801:Humans; D007239:Infections / Q000503:physiopathology; D008297:Male; D008659:Metabolic Diseases / Q000503:physiopathology; D008875:Middle Aged; D009410:Nerve Degeneration; D009460:Neurologic Examination; D011115:Polyneuropathies / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*