[Hormone tolerance mechanism of prostate cancer].
One of the delicate problems in a cancer treatment is the acquisition of a tolerance for a medicine. Antiandrogen treatment is valid in treatment of prostate cancer, but the disease develops into hormone-refractory prostate cancer after a uniformity period. The molecular mechanisms of recurrence and endocrine therapy failure in prostate cancer have remained unclear. In this paper we discuss the hormone-refractory prostate cancer that has been reported by many investigators.
Tozawa
K
K
Dept. of Urology, Nagoya City University Medical School, Japan.
Kohri
K
K
D000726:Androgen Antagonists / Q000494:pharmacology; D017209:Apoptosis; D015815:Cell Adhesion Molecules / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000235:genetics* / Q000473:pathology; D011944:Receptors, Androgen / Q000737:chemistry / Q000235:genetics*
D000726:Androgen Antagonists; D015815:Cell Adhesion Molecules; D011944:Receptors, Androgen