Toxicity of aliphatic amines: structure-activity relationship.
SARs may enable the evaluation of the toxic potential of chemicals by drawing conclusions from available data on structurally-related chemicals, thus reducing the need for further testing. The Advisory Committee on Existing Chemicals of Environmental Relevance (BUA) [1,2] of the German Chemical Society (Gesellschaft Deutscher Chemiker [GDCh]) has compiled data on the toxicity and ecological impact for several groups of chemicals [3, 4]. In the present review, some common toxicological properties for aliphatic amines were revealed after evaluation and comparison of the toxicity data.
Greim
H
H
GSF-Institut für Toxikologie, Oberschleissheim, Germany.
Bury
D
D
Klimisch
H J
HJ
Oeben-Negele
M
M
Ziegler-Skylakakis
K
K
D000284:Administration, Oral; D000588:Amines / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D015197:Carcinogenicity Tests; D003877:Dermatitis, Contact / Q000209:etiology; D005128:Eye Diseases / Q000139:chemically induced; D005858:Germany; D007928:Lethal Dose 50; D009152:Mutagenicity Tests; D051381:Rats; D013329:Structure-Activity Relationship; D018675:Toxicity Tests
D000588:Amines