Insulinotropic action of 6-O-acyl-D-glucose esters.
Several 6-O-acyl-D-glucose esters were examined for their possible insulinotropic action in rats islets incubated for 90 minutes in the absence or presence of either D-glucose or L-leucine. As a rule, 6-O-acetyl-D-glucose and either medium- and long-chain acyl-D-glucose esters only exerted modest effects upon insulin release, much less pronounced than those previously recorded with hexose pentaacetate esters. Nevertheless, under suitable experimental conditions, 6-O-octanoyl-D-glucose and 6-O-decanoyl-D-glucose significantly augmented insulin output, suggesting that such esters could be used, instead of D-glucose itself, as cell nutrients.
Malaisse
W J
WJ
Laboratory of Experimental Medicine, Brussels Free University, Belgium. malaisse@med.ulb.ac.be
Kirk
O
O
D000818:Animals; D004952:Esters / Q000494:pharmacology; D005260:Female; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism*; D007930:Leucine / Q000494:pharmacology; D009005:Monosaccharides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
C110050:6-O-acetyl-D-glucose; D004952:Esters; D007328:Insulin; D009005:Monosaccharides; D007930:Leucine