PCPP as a parenteral adjuvant for diverse antigens.
The adjuvanticity of the phosphazene polymer, poly[di(carboxylatophenoxy) phosphazene] (PCPP) was examined with a diverse collection of immunogens. PCPP proved to be a potent adjuvant for trivalent influenza virus vaccine, tetanus toxoid, hepatitis B surface antigen, herpes simplex virus glycoprotein gD2 and the capsular polysaccharide, polyribosylribitolphosphate, from Haemophilus influenzae type b. Taken together these results clearly demonstrate the general utility of PCPP as an adjuvant. Furthermore, PCPP was a superior adjuvant at least with TT compared to similar negatively charged polyanions, polymethylacrylic acid and polyacrylic acid.
Payne
L G
LG
Virus Research Institute, Inc., Cambridge, MA, USA.
Van Nest
G
G
Barchfeld
G L
GL
Siber
G R
GR
Gupta
R K
RK
Jenkins
S A
SA
D000179:Acrylates; D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D001672:Biocompatible Materials; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011108:Polymers; D018139:Simplexvirus / Q000276:immunology; D018074:Vaccines, Conjugate / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology
D000179:Acrylates; D000276:Adjuvants, Immunologic; D001672:Biocompatible Materials; D018073:Haemophilus Vaccines; D006514:Hepatitis B Surface Antigens; D011108:Polymers; D018074:Vaccines, Conjugate; D014759:Viral Envelope Proteins; C040570:glycoprotein D-herpes simplex virus type 2; C045869:polybis(carbophenoxypropane)