Synthesis and biological activity of 11,19-bridged progestins.
A synthetic approach to 11,19-bridged progestins is described. The key step in the synthesis is a 6-endo-trig radical cyclisation. The new progestins were tested for their biological activities in vitro and in vivo and compared to those of known progestins.
Schwede
W
W
Research Laboratories of Schering AG, Berlin, Germany. wolfgang.schwede@schering.de
Fritzemeier
K H
KH
Halfbrodt
W
W
Krattenmacher
R
R
Muhn
P
P
Neef
G
G
Ottow
E
E
Schöllkopf
K
K
D000818:Animals; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011247:Pregnancy; D011372:Progestins / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D013739:Testosterone / Q000031:analogs & derivatives / Q000378:metabolism
D011372:Progestins; D011944:Receptors, Androgen; D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone; D013739:Testosterone