Fulminant hepatic failure associated with dicoumarol therapy.
Coumarins have been associated with non-predictable hepatic injury. In the case of dicoumarol, there is no hard evidence in the literature of a causal connection with liver damage. We report the case of a 73-year-old woman who developed a fatal liver disease of a mixed hepatocellular-cholestatic type after 3 months of treatment with dicoumarol. A thorough diagnostic work-up did not reveal any other possible cause of the liver disease.
Castedal
M
M
Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
Aldenborg
F
F
Olsson
R
R
D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D001728:Dicumarol / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008111:Liver Function Tests; D009336:Necrosis
D000925:Anticoagulants; D001728:Dicumarol