An investigation of FB interactions with poly(ethylene glycol) 6000, poly(ethylene glycol) 4000, and poly-epsilon-caprolactone by thermoanalytical and spectroscopic methods and modeling.
The interactions between flurbiprofen (FB) and different polymers are studied in order to improve the bioavailability of FB. FB-polymer phase diagrams [poly(ethylene glycol) (PEG) 4000, PEG 6000, and poly-epsilon-caprolactone] were constructed and compared with the modeling diagrams. Thermoanalytical methods (differential scanning calorimetry, thermomicroscopy) were used to construct the phase diagrams. Thermodynamic data were used to model the FB-polymer systems. The construction of the FB-polymer phase diagrams showed the existence of a stable invariant called "eutectic" characterized by (XE)exp, (TfE)exp, and (DeltaHfE)exp, the experimental eutectic composition, the experimental temperature, and the enthalpy of eutectic melting, respectively. Modeling confirmed the values for these parameters and was used to evaluate the different Flory-Huggins parameters chi for each FB-polymer mixture. chi values and the infrared spectra confirm that the interactions due to hydrogen bonds between FB and PEG 4000 are more numerous than between FB and PEG 6000 and also more numerous than between FB and poly-epsilon-caprolactone.
Lacoulonche
F
F
Laboratoire de Chimie Générale et Minérale, Faculté de pharmacie, 15, avenue Charles Flahault 34060, Montpellier Cedex 2, France.
Chauvet
A
A
Masse
J
J
Egea
M A
MA
Garcia
M L
ML
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D005480:Flurbiprofen / Q000737:chemistry*; D006860:Hydrogen Bonding; D008956:Models, Chemical; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D011091:Polyesters; C016240:polycaprolactone; D011092:Polyethylene Glycols; D005480:Flurbiprofen