title: AIDS-related primary lymphoma of the pleural cavity. A case report.
abstract: BACKGROUND
  Pleural effusions are common in patients with the acquired immunodeficiency syndrome (AIDS). Their most frequent causes are Kaposi's sarcoma and mycobacterial infections. We report cytologic, immunophenotypic and molecular features of a primary pleural non-Hodgkin's lymphoma (NHL) that represent an uncommon cause of isolated pleural effusion in patients with AIDS.
  
  
  METHODS
  A 66-year-old, human immunodeficiency virus-positive male presented with chest pain and dyspnea. He had no history of opportunistic infections or Kaposi's sarcoma. A chest radiography displayed a right-sided pleural effusion. Cytology of pleural fluid revealed lymphomatous cells with markedly irregular nuclei. Their immunophenotype was indeterminate. Computed tomography of the thorax and abdomen did not show any tumor mass. Molecular analysis demonstrated that the lymphomatous cells had a B-cell genotype and contained Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) DNA sequences.
  
  
  CONCLUSIONS
  This case belongs to a new subgroup of AIDS-related NHL that is characterized by unusual morphology, null immunophenotype, B-cell genotype and association with both KSHV and EBV.
authors.affiliation: Department of Pathology, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Mansour
authors.forename: F
authors.initials: F
authors.lastname: Charlotte
authors.forename: V
authors.initials: V
authors.lastname: Calvez
authors.forename: F
authors.initials: F
authors.lastname: Davi
authors.forename: H
authors.initials: H
authors.lastname: Merle-Béral
mesh_terms: D000368:Aged; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology; D008297:Male; D016066:Pleural Effusion, Malignant / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology