13-Hydroxyoctadecadienoic acid reverses epidermal hyperproliferation via selective inhibition of membrane protein kinase C-beta activity.
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Department of Dermatology, University of California, Davis 95616, USA.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D004075:Diglycerides / Q000633:toxicity*; D004817:Epidermis / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D006168:Guinea Pigs; D006965:Hyperplasia; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008041:Linoleic Acids / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D064546:Protein Kinase C beta; D051571:Protein Kinase C-alpha
D004075:Diglycerides; D007527:Isoenzymes; D008041:Linoleic Acids; C024348:13-hydroxy-9,11-octadecadienoic acid; C087857:protein kinase C gamma; D011493:Protein Kinase C; D064546:Protein Kinase C beta; D051571:Protein Kinase C-alpha