Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses.
We have investigated the role of MHC class I products and CD8 T cells in regulating Ab responses using beta2-microglobulin deficient (beta2m-/-) mice. Beta2m-/- mice produced stronger IgM and IgG responses than did control beta2m+/+ mice to both cellular and viral Ags. These Ab responses could be suppressed by infusion of activated B cells from beta2m+/+ mice. Further investigation showed that the beta2m-associated molecule on activated B cells that induced CD8 suppression was Qa-1 and that the Th2 component of CD4 cells was most affected by CD8-suppressive activity. Our findings suggest a novel pathway of Th inhibition in which B cell presentation of Qa-1-associated peptides stimulates CD8 suppressive activity.
Noble
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Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA.
Zhao
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ZS
Cantor
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H
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002478:Cells, Cultured; D018259:Herpesvirus 1, Human / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000502:physiology*; D007371:Interferon-gamma / Q000502:physiology; D008213:Lymphocyte Activation; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012756:Sheep; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics
D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens; D001613:beta 2-Microglobulin; D007371:Interferon-gamma