Inhibition of cellular uptake of folate by blocking synthesis of the membrane folate receptor.
The folate receptor, bound to the plasma membrane through a glycosylphosphatidylinositol anchor, requires both sphingolipids and cholesterol in the membrane for full activity. In recent studies, treatment of cells in culture with the mycotoxin fumonisin B1, which inhibits sphingolipid synthesis, virtually abolished uptake of 5-methyltetrahydrofolate.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
D000818:Animals; D002264:Carboxylic Acids / Q000494:pharmacology*; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000493:pharmacokinetics*; D037341:Fumonisins; D006801:Humans; D011956:Receptors, Cell Surface; D013107:Sphingolipids / Q000096:biosynthesis; D013723:Teratogens / Q000494:pharmacology*
D002264:Carboxylic Acids; D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D037341:Fumonisins; D011956:Receptors, Cell Surface; D013107:Sphingolipids; D013723:Teratogens; C056933:fumonisin B1; D005492:Folic Acid