Studies on the Synthesis of Elegan-Type Linear Diterpenes: The Efficient Total Syntheses of Eleganolone, Eleganolone Acetate, Elegandiol, Eleganonal, and Epoxyeleganolone
The first total syntheses of five elegan-type linear diterpenes-eleganolone (1), eleganolone acetate (2), elegandiol (3), eleganonal (4), and epoxyeleganolone (5)-were accomplished starting from (E,E)-farnesol (6) via four to six steps, successively, with high overall yield. The key step was the alkylation reaction of silyl cyanide with allylic iodide.
Li
J
National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
Lan
J
Liu
Z
Li
Y