title: Contribution of parental blood pressures to association between low birth weight and adult high blood pressure: cross sectional study.
abstract: OBJECTIVE
  To examine the possibility that low birth weight is a feature of the inherited predisposition to high blood pressure.
  
  
  METHODS
  Cross sectional study.
  
  
  METHODS
  Primary care medical centre in Edinburgh.
  
  
  METHODS
  One offspring of 452 families (231 men and 221 women aged 16-26 years) in whom blood pressure, weight, and height were measured in 1986 and whose parents had blood pressure measured in 1979. Birth weights were obtained from case records (270 offspring) or by questionnaires sent to the mothers (182 offspring).
  
  
  METHODS
  Birth weight and adult systolic blood pressure in offspring in relation to parental blood pressure.
  
  
  RESULTS
  If parental blood pressures were not considered, a 1 kg decrease in birth weight was associated with a 2.24 mm Hg increase in systolic blood pressure of offspring (P = 0.06) after correction for current weight and sex. However, parental blood pressures correlated positively with blood pressure of offspring, and higher maternal blood pressure was associated with lower birth weight (-3.03 g/mm Hg, P < 0.01). After correction for parental blood pressures, a 1 kg decrease in birth weight was associated with only a 1.71 mm Hg increase in the systolic blood pressure of the offspring (P = 0.15).
  
  
  CONCLUSIONS
  Low birth weight is a feature of the inherited predisposition to hypertension, perhaps because it is associated with higher maternal blood pressure during pregnancy. Parental blood pressure may be an important confounding factor in the relation between low birth weight and subsequent hypertension.
authors.affiliation: Department of Medicine, University of Edinburgh, Western General Hospital.
authors.forename: B R
authors.initials: BR
authors.lastname: Walker
authors.forename: A
authors.initials: A
authors.lastname: McConnachie
authors.forename: J P
authors.initials: JP
authors.lastname: Noon
authors.forename: D J
authors.initials: DJ
authors.lastname: Webb
authors.forename: G C
authors.initials: GC
authors.lastname: Watt
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D001794:Blood Pressure / Q000502:physiology*; D001827:Body Height; D001835:Body Weight; D003430:Cross-Sectional Studies; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007230:Infant, Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010290:Parents; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012606:Scotland / Q000453:epidemiology; D017678:Sex Distribution