title: Myocardial infarction induces expression of midkine, a heparin-binding growth factor with reparative activity.
abstract: We examined midkine (MK) expression in the rat heart upon experimental myocardial infarction. Immunohistochemical staining revealed, 6 hours after ligation of the left anterior descending coronary artery, strong MK immunoreactivity in myocytes and endothelial cells of a non-infarcted cardiac region. The myocytes of the infarcted cardiac region destined for death showed only a little immunoreactivity. Northern blot analysis suggested that the increased immunoreactivity was due to increased MK synthesis. The induced MK expression is likely to mimic the expression during embryogenesis: MK was strong lye-expressed in the myocytes of embryonic heart, and the expression decreased during embryogenesis.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Obama
authors.forename: S
authors.initials: S
authors.lastname: Biro
authors.forename: T
authors.initials: T
authors.lastname: Tashiro
authors.forename: J
authors.initials: J
authors.lastname: Tsutsui
authors.forename: M
authors.initials: M
authors.lastname: Ozawa
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Muramatsu
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D016207:Cytokines; D015870:Gene Expression; D005865:Gestational Age; D006133:Growth Substances / Q000378:metabolism*; D006321:Heart / Q000196:embryology; D007124:Immunoenzyme Techniques; D008297:Male; D000078792:Midkine; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; D006133:Growth Substances; D012333:RNA, Messenger; D000078792:Midkine