title: Depletion of calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat after electrical stimulation of the Gasserian ganglion.
abstract: Electrical stimulation of the Gasserian ganglion resulted in partial depletion of calcitonin gene-related peptide (CGRP) from ipsilateral central terminals of pseudounipolar primary sensory ganglion cells. Affected terminals exhibit decreased CGRP immunoreactivity as shown by cytophotometric densitometry of the caudal trigeminal nucleus. The decrease in CGRP immunoreactivity is statistically significant only in the medial one-third of the caudal trigeminal nucleus. Since earlier studies have shown that electrical stimulation of the Gasserian ganglion induces first accumulation then depletion of CGRP from perivascular sensory terminals in the dura mater, the present experiments suggest that CGRP is depleted also from central terminals of primary sensory trigeminal neurons, which might be of importance in the pathogenesis of migraine headache.
authors.affiliation: Department of Clinical Neurology, Albert Szent-Györgyi University Medical School, Szeged, Hungary. knyihar@nepsy.szote.u-szeged.hu
authors.forename: E
authors.initials: E
authors.lastname: Knyihár-Csillik
authors.forename: J
authors.initials: J
authors.lastname: Tajti
authors.forename: M
authors.initials: M
authors.lastname: Samsam
authors.forename: G
authors.initials: G
authors.lastname: Sáry
authors.forename: P
authors.initials: P
authors.lastname: Buzás
authors.forename: L
authors.initials: L
authors.lastname: Vécsei
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis / Q000172:deficiency*; D003720:Densitometry; D004558:Electric Stimulation; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D014275:Trigeminal Caudal Nucleus / Q000502:physiology*; D012668:Trigeminal Ganglion / Q000502:physiology*
chemical_list: D015740:Calcitonin Gene-Related Peptide