title: Tumours of the minor salivary glands.
abstract: One hundred and forty-five patients were identified with minor salivary gland tumours. General information and tumour-specific information on stage, grade of tumour, resection margins, recurrence and survival were collected. Data was analysed by both univariate and multivariate methods. Indices predicting tumour recurrence and survival were analysed. Forty-two benign lesions, mostly pleomorphic adenomas were identified, one recurred, all survived. One hundred and three malignant lesions were identified, mostly adenoid cystic carcinomas (70%) or mucoepidermoid carcinomas (19%). Late stage disease and the presence of neck node metastases predicted both early recurrence and high eventual mortality. Survival was favoured by the histological type (mucoepidermoid > adenoid cystic), site of primary (oral cavity and oropharynx > nose, sinuses and larynx) and good general condition. Many tumours recurred after 5 years of disease-free survival and late mortality was a feature (80% survival at 5 years, 20% at 20 years). Many patients survive some time with either local recurrence or distant metastases. Long-term follow-up is advocated as local or distant recurrence may be treatable. The value of super radical treatment of the primary is questionable given the likelihood of recurrence at distant sites.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, University of Liverpool, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Jones
authors.forename: N J
authors.initials: NJ
authors.lastname: Beasley
authors.forename: D J
authors.initials: DJ
authors.lastname: Houghton
authors.forename: T R
authors.initials: TR
authors.lastname: Helliwell
authors.forename: D J
authors.initials: DJ
authors.lastname: Husband
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000601:surgery; D000328:Adult; D003528:Carcinoma, Adenoid Cystic / Q000453:epidemiology / Q000601:surgery; D018277:Carcinoma, Mucoepidermoid / Q000453:epidemiology / Q000601:surgery; D016208:Databases, Factual; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D016016:Proportional Hazards Models; D012466:Salivary Gland Diseases / Q000453:epidemiology; D012468:Salivary Gland Neoplasms / Q000453:epidemiology* / Q000601:surgery; D012470:Salivary Glands, Minor; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors