Further studies on analgesic activity of cyclic imides.
As part of our research programme to obtain pharmacologically active compounds structurally related to cyclic imides, we have synthesized different compounds and examined their analgesic activities using the abdominal constriction test in mice. The results showed that some of the compounds studied, given intraperitoneally, exhibited graded and significant analgesia against acetic acid-induced abdominal constriction, being several times more potent than aspirin and paracetamol, two standard drugs used for comparison.
Cechinel Filho
V
V
Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/FAQFAR, Universidade do Vale do Itají (UNIVALI), Brazil.
Corrêa
R
R
Vaz
Z
Z
Calixto
J B
JB
Nunes
R J
RJ
Pinheiro
T R
TR
Andricopulo
A D
AD
Yunes
R A
RA
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D007094:Imides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship
D000700:Analgesics; D007094:Imides