The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions.
Houslay
M D
MD
Division of Biochemistry and Molecular Biology, University of Glasgow, Scotland, UK.
Sullivan
M
M
Bolger
G B
GB
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000235:genetics / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D003866:Depressive Disorder / Q000188:drug therapy / Q000201:enzymology*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000201:enzymology*; D008969:Molecular Sequence Data; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D016415:Sequence Alignment
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000928:Antidepressive Agents; D004791:Enzyme Inhibitors; D010726:Phosphodiesterase Inhibitors; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4