Hemolytic anemia associated with cold agglutinin during chickenpox and a review of the literature.
OBJECTIVE
To describe the findings and cause of anemia and jaundice in a 2-year-old boy.


METHODS
This boy was admitted with a hemoglobin of 7.8 g/dL, a bilirubin of 1.8 mg/dL, and increased urobilinogen.


RESULTS
On the second day after admission, hemolytic anemia associated with an anti-I cold agglutinin was diagnosed, which was transient and recovered without any treatment.


CONCLUSIONS
This is a very rare complication of chickenpox; only five cases have been previously reported and these were all characterized by anti-Pr cold agglutinin with hemolytic anemia after the onset of chickenpox. We report the first case of hemolytic anemia associated with an anti-I cold agglutinin during the incubation period of chickenpox.
Terada
K
K
Department of Pediatrics, Kawasaki Medical School, Okayama, Japan.
Tanaka
H
H
Mori
R
R
Kataoka
N
N
Uchikawa
M
M
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology*; D002644:Chickenpox / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male