title: Oxyfedrine in myocardial stunning.
abstract: Effect of oxyfedrine (OXF)(1 mg/kg) administered just before reperfusion (post-treatment) was investigated in a canine model of myocardial stunning. In the saline-treated animals, myocardial stunning was evidenced by fall in MAP, decrease in LV peak (+) dP/dt, rise in LVEDP and incomplete regeneration of myocardial ATP, after reperfusion. OXF was found to be effective in preventing the haemodynamic and metabolic changes associated with myocardial stunning.
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Maulik
authors.forename: S D
authors.initials: SD
authors.lastname: Seth
authors.forename: M
authors.initials: M
authors.lastname: Maulik
authors.forename: S C
authors.initials: SC
authors.lastname: Manchanda
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D017682:Myocardial Stunning / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism; D010099:Oxyfedrine / Q000627:therapeutic use*
chemical_list: D002316:Cardiotonic Agents; D010099:Oxyfedrine