title: Donor des-gamma-carboxy prothrombin positivity is a risk factor for poor early graft function in liver transplantation.
abstract: Des-gamma-carboxy prothrombin (DCP) is an abnormal prothrombin that lacks coagulating activity. The aim of this study was to determine if the presence of DCP in the donor could be used as a marker of post-transplant graft function. We collected data and serum samples on 90 organ donors. DCP level was correlated with donor-specific factors and with graft function intraoperatively and in the early post-transplant period. Twenty-seven donors (30.0%) had positive DCP levels before harvesting. Although recipients were similar in demographics, preoperative liver function, and primary disease distribution, patients transplanted with livers from DCP-positive donors needed significantly more intraoperative transfusion. Furthermore, donor DCP positivity was identified as a preoperative risk factor for poor early graft function based on multivariate analysis (odds ratio = 6.58, P = 0.0032). Our findings suggest that DCP is another valuable marker for evaluating the quality of donor livers.
authors.affiliation: Department of Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: T
authors.initials: T
authors.lastname: Suehiro
authors.forename: P
authors.initials: P
authors.lastname: Boros
authors.forename: S
authors.initials: S
authors.lastname: Emre
authors.forename: P A
authors.initials: PA
authors.lastname: Sheiner
authors.forename: S
authors.initials: S
authors.lastname: Guy
authors.forename: M E
authors.initials: ME
authors.lastname: Schwartz
authors.forename: C M
authors.initials: CM
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002648:Child; D005260:Female; D006084:Graft Rejection / Q000097:blood; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D011516:Prothrombin / Q000031:analogs & derivatives* / Q000378:metabolism; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C065848:prothrombin, Gla(9)-; D011516:Prothrombin