title: Cellular responses in exertion-induced skeletal muscle injury.
abstract: Muscle injury is a common result of muscle exertion caused by overload and over-activity. In this presentation, an attempt was made to discuss models of muscle injury which involve exertion but not excessive strain, although most functional activities of the extremities require some eccentric muscle actions. Muscle injury is characterized by cellular and extracellular matrix responses which appear to be common to all types of muscle trauma -- even in the absence of bleeding. Using tenotomy and functional over-load of the rat hindlimb muscles as examples, illustrations of several of these responses are presented and discussed.
authors.affiliation: Department of Physiology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown 26506-9229, USA.
authors.forename: W T
authors.initials: WT
authors.lastname: Stauber
authors.forename: C A
authors.initials: CA
authors.lastname: Smith
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000378:metabolism; D006614:Hindlimb / Q000502:physiology; D007150:Immunohistochemistry; D018482:Muscle, Skeletal / Q000473:pathology*; D009210:Myofibrils / Q000473:pathology; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D013744:Tetanus Toxin / Q000494:pharmacology
chemical_list: D013744:Tetanus Toxin