Cloning of the cDNA encoding rat presenilin-2.
We report here the cDNA sequence of rat homologue of presenilin-2 (PS-2). The rat PS-2 cDNA encoded 448 amino acids, and the deduced amino acid sequence was highly homologous to those of the human (94.9%), mouse (96.4%) and Xenopus (70.8%). A minor splicing variant lacking a single glutamate was detected, while the product corresponding to the exon 9 deleted splicing variant observed in human was not detected.
Tanahashi
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Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan. tanahashi@ncnpja.ncnp.go.jp
Tabira
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D017398:Alternative Splicing; D000544:Alzheimer Disease / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000302:isolation & purification*; D006801:Humans; D007962:Leukocytes; D008565:Membrane Proteins / Q000235:genetics* / Q000302:isolation & purification; D051379:Mice; D008969:Molecular Sequence Data; D053766:Presenilin-2; D051381:Rats; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014981:Xenopus
D018076:DNA, Complementary; D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2