title: Mechanisms of secretion of toxic organic anions in mammalian kidneys.
abstract: This short review considers the mechanisms of organic anion secretion in renal proximal tubules. Particular attention is given to the energy coupling of p-aminohippurate transport to inorganic anion gradients generated across both basolateral and brush-border membranes. The coupling is considered to be a consequence of the combined operation of the co-transport and anion-exchange mechanisms. A possible coexistence of several organic anion pathways with overlapping substrate specificity and/or energetic dependence of the total ion gradient are suggested. The problem of identification of transporters involved in organic anion secretion is discussed.
authors.affiliation: St. Petersburg Institute of Nuclear Physics, Russian Academy of Sciences, Russia. orlov@bird.macro.ru
authors.lastname: Orlov YuN
mesh_terms: D000818:Animals; D027321:Anion Transport Proteins; D000838:Anions / Q000378:metabolism*; D001692:Biological Transport; D002352:Carrier Proteins / Q000502:physiology; D006801:Humans; D016623:Ion Pumps / Q000502:physiology*; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008322:Mammals; D014118:Toxins, Biological / Q000378:metabolism*
chemical_list: D027321:Anion Transport Proteins; D000838:Anions; D002352:Carrier Proteins; D016623:Ion Pumps; D014118:Toxins, Biological