The 5-HT3 receptor agonist attenuates the action of antidepressants in the forced swim test in rats.
Involvement of 5-hydroxytryptamine (5-HT)3 receptors in action of antidepressants was examined in the forced swim test in rats. Rats were forced to swim in a cylinder for 15 min on day 1 and for 5 min on day 2. Imipramine, desipramine and mianserin, administered after the 15-min swim session on day 1 and before the 5-min swim test on day 2, dose-dependently decreased the duration of immobility in the swim test on day 2. 1-(m-Chlorophenyl)-biguanide (mCPBG) attenuated the decreased duration of immobility induced by imipramine, desipramine and mianserin, although mCPBG did not affect the duration of immobility when it was given alone. ICS205-930 dose-dependently decreased the duration of immobility in the swim test on day 2, and the effect of ICS205-930 was attenuated by mCPBG. These results suggest that the suppression of 5-HT3 receptor activity may contribute to the action of antidepressants.
Nakagawa
Y
Y
Tsukuba Research Laboratories, Experimental Biomedical Research (Jisseiken), 8-5-1, Chuo, Ami-machi, Inashiki-gun, Ibaraki 300-03, Japan.
Ishima
T
T
Takashima
T
T
D000818:Animals; D000928:Antidepressive Agents / Q000037:antagonists & inhibitors*; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001645:Biguanides / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013550:Swimming; D000077526:Tropisetron; D014836:Volition
D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D001645:Biguanides; D007211:Indoles; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D008803:Mianserin; D000077526:Tropisetron; C065734:1-(3-chlorophenyl)biguanide; D007099:Imipramine; D003891:Desipramine