title: Human enamel as a substrate for in vitro acid dissolution studies: influence of tooth surface and morphology.
abstract: The variation in susceptibility of enamel to acid dissolution has been quantitatively assessed in vitro by examination of different surfaces of both maxillary and mandibular teeth of different morphology obtained from a pool of sound human teeth. The lingual/palatal surfaces of all teeth showed greater susceptibility to acid dissolution than the corresponding labial/buccal surfaces. The palatal surface of the maxillary teeth appeared more susceptible to acid than the lingual surface of the corresponding teeth in the mandible. The palatal surfaces of the maxillary teeth showed least variation in acid susceptibility, whilst the lingual surfaces of mandibular teeth and buccal/labial surfaces of teeth from both jaws showed much more variation between teeth of different morphology. These differences in susceptibility to acid dissolution probably reflect both developmental differences and post-eruptive changes in enamel and may contribute to the clinical presentation of dental disease. Importantly, the data indicates that careful selection of teeth for in vitro study of enamel dissolution processes is essential to minimise inter-sample variation. For such purposes, the palatal surface of the maxillary teeth appears to be most suitable.
authors.affiliation: School of Dentistry, University of Birmingham, UK.
authors.forename: K
authors.initials: K
authors.lastname: Tucker
authors.forename: M
authors.initials: M
authors.lastname: Adams
authors.forename: L
authors.initials: L
authors.lastname: Shaw
authors.forename: A J
authors.initials: AJ
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D019343:Citric Acid / Q000494:pharmacology; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects; D003747:Dental Enamel Solubility; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged; D013379:Substrate Specificity; D014070:Tooth / Q000033:anatomy & histology; D017001:Tooth Demineralization / Q000139:chemically induced
chemical_list: D019343:Citric Acid