Labeling of penicillamine di sulfide with technetium-99m.
Complex forming conditions of Penicillamine di sulfide with 99mTc have been specified. Labeling of penicillamine di sulfide with 99mTc by direct reduction with SnCl2 did not give favorable good results while the 99mTc complex of penicillamine can be easily obtained. Ligand exchange reaction with 99mTc-gluconate was attempted and a 95% labeling efficiency was obtained. Radiopharmaceutical potential of 99mTc-PADS (99mTc-Penicillamine di sulfide) has been investigated with a gamma camera in rabbits and the complex was found to be uptaken mostly by the liver and kidneys.
Unak
P
P
Institute of Nuclear Sciences, Ege University, Bornova, Izmir, Turkey.
Tunç
M
M
Duman
Y
Y
D000818:Animals; D005942:Gluconates / Q000737:chemistry; D007553:Isotope Labeling / Q000379:methods; D008024:Ligands; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D010396:Penicillamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D005942:Gluconates; D008024:Ligands; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C032080:technetium Tc 99m gluconate; C036114:technetium Tc 99m penicillamine; C036069:penicillamine disulfide; D010396:Penicillamine