[Variant of the Hodgkin-Huxley model with a reduced number of parameters].
The time constants of variations in sodium and potassium conductances of neural cell membrane have been investigated as a function of transmembrane potential. It is shown that the dependences can be described by the model of self-organization and self-regulation in open dynamic systems reported early. This approach has two advantages over the empirical formulae by Hodgkin and Huxley: 1) the number of parameters to be defined is substantially reduced, which simplifies modeling of real cells, and 2) the model involves a particular mechanisms by which the transmembrane potential regulates the time constants of variations in membrane conductance, which can promote further development of theoretical conceptions of the action potential generation process.
Tsvetkov
O V
OV
Research Centre of the Ministry of Defense of Russia, St. Petersburg, Russia.
Degtiarev
G M
GM
Smirnova
E P
EP
D000200:Action Potentials; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D007700:Kinetics; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D011188:Potassium