title: [T1-weighted dynamic MRI with new superparamagnetic iron oxide particles (Resovist): results of a phantom study as well as 25 patients].
abstract: OBJECTIVE
  Evaluation of the diagnostic usefulness of the T1-effect of Resovist (SPIO) for dynamic MRI of the liver.
  
  
  METHODS
  In-vitro measurements of a dilution series with T1-weighted FLASH and SE sequences and investigation of 25 patients with known focal liver lesions with a T2-weighted TSE sequence and a dynamic T1-FLASH sequence.
  
  
  RESULTS
  T1-weighted MRI with Resovist in vitro showed a positive enhancement at low concentrations and a negative enhancement at higher concentrations. In-vivo T1-weighted dynamic MRI liver parenchyma demonstrated a positive enhancement 30 s post contrast, followed by a continuous slope of signal intensity and a negative enhancement (> or = 60 s). Spleen, portal venous vessels and haemangiomas showed an early increase in signal intensity followed by a decreasing positive enhancement, but without negative enhancement. During the perfusion phase metastases showed a small but not significant increase in signal intensity. In 80% a positive ring enhancement could be observed around metastases.
  
  
  CONCLUSIONS
  Resovist exhibits a diagnostically useful T1-effect. An evaluation of the perfusion of focal liver lesions during the distribution phase is possible with dynamic T1-weighted MRI. This approach may further improve characterisation of focal liver lesions.
authors.affiliation: Institut für Klinische Radiologie, Westfälische Wilhelms-Universität Münster.
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: P
authors.initials: P
authors.lastname: Reimer
authors.forename: D
authors.initials: D
authors.lastname: Wiedermann
authors.forename: T
authors.initials: T
authors.lastname: Allkemper
authors.forename: C
authors.initials: C
authors.lastname: Marx
authors.forename: B
authors.initials: B
authors.lastname: Tombach
authors.forename: E J
authors.initials: EJ
authors.lastname: Rummeny
authors.forename: K
authors.initials: K
authors.lastname: Shamsi
authors.forename: T
authors.initials: T
authors.lastname: Balzer
authors.forename: P E
authors.initials: PE
authors.lastname: Peters
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D003911:Dextrans; D005260:Female; D052203:Ferrosoferric Oxide; D006391:Hemangioma / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007501:Iron; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D010087:Oxides; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology; D019047:Phantoms, Imaging; D011168:Portal System / Q000473:pathology; D015203:Reproducibility of Results; D013154:Spleen / Q000473:pathology
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide