Rapid progression to invasive cervix cancer in a woman infected with the human immunodeficiency virus.
BACKGROUND
Previous studies have shown an increased risk of cervical dysplasia in women infected with human immunodeficiency virus (HIV), as well as an increased risk of progression to higher-grade lesions. It is not known whether the rate of progression is accelerated over that in immunocompetent women.


METHODS
During September 1991, an HIV-positive woman underwent conization of the cervix showing carcinoma in situ. The surgical margins and endocervical curettings were negative for dysplasia. Papanicolaou smears 4 and 7 months after the conization also were negative. She then presented 33 months postconization with a stage Ib2 cervical carcinoma, which proved resistant to chemotherapy and pelvic radiation.


CONCLUSIONS
Immunosuppression caused by HIV infection may cause a more rapid progression of cervical intraepithelial lesions to carcinoma.
Holcomb
K
K
Department of Obstetrics and Gynecology, State University of New York-Health Science Center at Brooklyn, USA. kholc@msn.com
Maiman
M
M
Dimaio
T
T
Gates
J
J
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000473:pathology