Elimination of oxolinic acid in eggs after oral treatment of laying hens.
1. Oxolinic acid is often used in poultry as a therapeutic agent. The aim of this study was to determine both its elimination into eggs, following oral dosing through the drinking water (12 mg/kg/d) or diet (13 mg/kg/d) for 5 d and its plasma concentrations. 2. Samples (albumen, yolk, plasma) were analysed by high performance liquid chromatography (HPLC) with fluorimetric detection. The limits of quantification were 10 ng/g in plasma and 5 ng/g in albumen and yolk. Residues were much higher in albumen than in plasma, whereas they were lower in yolk. 3. 95% of the overall oxolinic acid detected in eggs was concentrated in the albumen. 4. Detectable residues persisted for 9 d and 7 d, respectively, in albumen and yolk after the treatment was discontinued.
Roudaut
B
B
CNEVA, Laboratoire des Médicaments Vétérinaires, Fougères, France.
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis; D004530:Egg Yolk / Q000737:chemistry; D004531:Eggs / Q000032:analysis*; D005260:Female; D008657:Metabolic Clearance Rate; D010047:Ovalbumin / Q000032:analysis; D010058:Oviposition; D010093:Oxolinic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D000890:Anti-Infective Agents; D010047:Ovalbumin; D010093:Oxolinic Acid