title: Localization of metallothionein-I and -II in hypertrophic astrocytes in brain lesions of dogs.
abstract: To study the neurophysiological functions of metallothioneins (MTs), localization of MT-I and -II was examined immunohistochemically in a variety of brain lesions in dogs, including infarct, laminar cortical necrosis, hemorrhage, invasive growth of tumour, inflammatory lesions in granulomatous meningoencephalitis and distemper encephalitis. MT-I and -II were demonstrated in both nucleus and cytoplasm of hypertrophic astrocytes in most brain lesions examined regardless of the type, size, localization and duration of the lesions. In addition, MT expression was stronger in a population of hypertrophic astrocytes localizing inside of the surviving brain tissue rather than those localizing at the boundary between the surviving brain tissue and necrotic area, where severe inflammatory changes were developing. These results suggest that MT-I and -II may play roles not only in protection of neurons from metals and free radicals ubiquitous in the inflammatory lesions but also in repair of injured neural tissues.
authors.affiliation: Department of Veterinary Pathology, Tottori University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Uemura
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamura
authors.forename: S
authors.initials: S
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: T
authors.initials: T
authors.lastname: Umemura
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary / Q000662:veterinary; D000818:Animals; D001253:Astrocytes / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology / Q000662:veterinary*; D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary / Q000662:veterinary*; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000662:veterinary; D002544:Cerebral Infarction / Q000473:pathology / Q000662:veterinary; D004216:Distemper / Q000473:pathology; D004283:Dog Diseases; D004285:Dogs; D018792:Encephalitis, Viral / Q000473:pathology / Q000662:veterinary; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006984:Hypertrophy; D007249:Inflammation; D008297:Male; D008590:Meningoencephalitis / Q000473:pathology / Q000662:veterinary; D008668:Metallothionein / Q000032:analysis*; D009336:Necrosis; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000473:pathology / Q000662:veterinary*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D008668:Metallothionein