T-cell-rich B-cell lymphoma and Epstein-Barr virus infection of the uterus in a postmenopausal patient with an intrauterine contraceptive device in place for over 20 years.
Although secondary involvement of the female genital tract occurs in up to 40% of cases of disseminated lymphomas, lymphomas presenting with primary female genital tract symptomatology are very unusual. We report a case of T-cell-rich B-cell lymphoma (TCRBCL) arising in the uterine corpus of a 57-year-old female who carried an intrauterine contraceptive device (IUD) for over 20 years. Malignant lymphoid cells expressed the Epstein-Barr virus (EBV) late membrane protein (LMP), a feature described in TCRBCL but not previously reported in primary uterine lymphomas. To our knowledge, this is the first reported case of a TCRBCL of the uterus.
Gutman
P D
PD
Department of Laboratory Medicine, National Naval Medical Center, Bethesda, Maryland, USA.
Williams
J P
JP
Dveksler
G S
GS
Hoffmeister
K
K
Cotelingam
J D
JD
D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006566:Herpesviridae Infections / Q000209:etiology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007434:Intrauterine Devices / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000473:pathology* / Q000821:virology; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D017698:Postmenopause; D013601:T-Lymphocytes / Q000473:pathology*; D014412:Tumor Virus Infections / Q000209:etiology*; D014591:Uterine Diseases / Q000209:etiology / Q000821:virology*; D014594:Uterine Neoplasms / Q000209:etiology / Q000821:virology*
D004273:DNA, Neoplasm