title: [Aging and cardiology; various physiological, pathophysiological and clinical aspects].
abstract: The main cardiovascular effect of aging is a rise of the systolic blood pressure due to reduced impedance of the central arteries. The resulting increase of the afterload leads to hypertrophy, increased rigidity and lengthening of the relaxation period in the left ventricle. The manifestations of ischaemia or arrhythmias are often atypical at more advanced ages and may delay diagnosis. Ejection murmur due to stenosis of the aortic valve, to calcification or degeneration, may be difficult to distinguish from a functional murmur. The cause of heart failure is usually coronary sclerosis and, less often, hypertension or a valvular defect. Systolic heart failure is associated with decreased contractility of the left ventricle and compensatory dilation, diastolic heart failure with reduced filling of the ventricles. Both forms respond well to acute treatment with antihypertensive, diuretic and (or) vasodilator drugs; the treatment in isolated diastolic heart failure should also focus on lowering the increased blood pressure and reducing the heart rate to increase the filling phase.
authors.affiliation: Afd Cardiologie, Academisch Medisch Centrum, Amsterdam.
authors.forename: R
authors.initials: R
authors.lastname: Tukkie
authors.forename: D R
authors.initials: DR
authors.lastname: Düren
authors.forename: R B
authors.initials: RB
authors.lastname: van den Brink
authors.forename: K I
authors.initials: KI
authors.lastname: Lie
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D006331:Heart Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans
chemical_list: D002317:Cardiovascular Agents