title: Mycobacterium leprae binds to a 25-kDa phosphorylated glycoprotein of human peripheral nerve.
abstract: Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from human peripheral nerve. This protein is phosphorylatable and it binds to lectins which have alpha-mannose specificity. This M leprae-protein interaction could be of importance in the pathogenesis of leprosy.
authors.affiliation: Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, TN, India.
authors.forename: L M
authors.initials: LM
authors.lastname: Suneetha
authors.forename: P R
authors.initials: PR
authors.lastname: Satish
authors.forename: R J
authors.initials: RJ
authors.lastname: Korula
authors.forename: S K
authors.initials: SK
authors.lastname: Suneetha
authors.forename: C K
authors.initials: CK
authors.lastname: Job
authors.forename: A S
authors.initials: AS
authors.lastname: Balasubramanian
mesh_terms: D001345:Autoradiography; D001426:Bacterial Proteins / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D004926:Escherichia coli / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000378:metabolism; D008970:Molecular Weight; D009163:Mycobacterium bovis / Q000378:metabolism; D009166:Mycobacterium leprae / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding; D013979:Tibial Nerve / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D006023:Glycoproteins; D037102:Lectins; D009419:Nerve Tissue Proteins