title: [Quantification of left-to-right shunt in atrial septal defect using oximetry, isotopes, and Doppler echocardiography. Is there a method of reference?].
abstract: BACKGROUND
  Determination of pulmonary to systemic blood flow ratio (QP/QS) is considered to be important for the management of patients with atrial septal defect. The QP/QS provides information on shunt severity and is usually determined by three methods: oximetry, first-pass radionuclide angiocardiography and Doppler echocardiography. The aim of the present study was to assess the accuracy and concordance level of these three methods in QP/QS quantification in atrial septal defects.
  
  
  METHODS
  Sixty-four adult atrial septal defects patients in whom QP/QS was determined by these three methods with a 6 month interval were studied. Nuclear and echocardiographic post-surgical studies were repeated in 36 patients.
  
  
  RESULTS
  QP/QS values determined by the three techniques had a low correlation between them: oximetry (r = 0.52; SEE = 0.74); radionuclide angiocardiography (r = 0.40; SEE = 0.79) and Doppler echocardiography (r = 0.72; SEE = 0.57). Radionuclide angiocardiography underestimated QP/QS > 3 (-0.61 +/- 1.21; p < 0.01). Only in 33% of studies there concordance (differences < 0.5) among the three methods and in 58% between two methods. Right ventricular dilatation and tricuspid regurgitation influenced radionuclide accuracy. Nevertheless, the correlation between this technique and echocardiography was satisfactory when the 36 post-surgical were included (r = 0.75); both techniques agreed in the diagnosis of the two cases with residual post-surgical shunt.
  
  
  CONCLUSIONS
  Inter-method disparity in QP/QS quantification is high and no method can be used as a gold standard; clinical decisions therefore based on QP/QS quantification by one technique alone are ill-advised.
authors.affiliation: Servicio de Cardiología, Hospital General Universitari Vall d'Hebron, Barcelona.
authors.forename: A
authors.initials: A
authors.lastname: Evangelista
authors.forename: S
authors.initials: S
authors.lastname: Aguadé
authors.forename: J
authors.initials: J
authors.lastname: Candell-Riera
authors.forename: J
authors.initials: J
authors.lastname: Angel
authors.forename: E
authors.initials: E
authors.lastname: Galve
authors.forename: H
authors.initials: H
authors.lastname: García del Castillo
authors.forename: T
authors.initials: T
authors.lastname: González-Alujas
authors.forename: J
authors.initials: J
authors.lastname: Soler-Soler
mesh_terms: D000328:Adult; D000368:Aged; D003326:Coronary Circulation; D015150:Echocardiography, Doppler; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D011446:Prospective Studies; D011652:Pulmonary Circulation; D015646:Ventriculography, First-Pass