[Glomerulonephritis caused by acute serum sickness].
A 51-year-old male patient was treated for a rejection episode after kidney transplantation with horse antithymocyte globulin (ATG). Twelve days after the start of the ATG treatment he developed fever, arthralgia, purpura and acute renal failure. This clinical picture is characteristic of serum sickness, resulting from formation of antibodies to a foreign protein and development of immune complexes. Kidney biopsy revealed an endocapillary glomerulonephritis. Immune complexes probably develop in the mesangium and along the glomerular basal membrane through local formation and precipitation from the circulation. Spontaneous recovery is the rule.
Andrésdóttir
M B
MB
Afd. Nierziekten, Academisch Ziekenhuis, Nijmegen.
Assmann
K J
KJ
Wetzels
J F
JF
D000208:Acute Disease; D000293:Adolescent; D000961:Antilymphocyte Serum / Q000009:adverse effects* / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D006084:Graft Rejection / Q000628:therapy; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012713:Serum Sickness / Q000150:complications* / Q000209:etiology; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum