Activation of cardiac EP3 receptors by PGE1 reduces beta-adrenergic inotropic effects.
Hohlfeld
T
T
Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, Germany.
Schrör
K
K
D000262:Adenylyl Cyclases / Q000378:metabolism; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists; D000527:Alprostadil / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D018078:Receptors, Prostaglandin E / Q000378:metabolism / Q000502:physiology*; D058308:Receptors, Prostaglandin E, EP3 Subtype; D012508:Sarcolemma / Q000201:enzymology; D013552:Swine; D013556:Swine, Miniature; D014316:Tritium; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D018078:Receptors, Prostaglandin E; D058308:Receptors, Prostaglandin E, EP3 Subtype; D014316:Tritium; D005576:Colforsin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000527:Alprostadil; D007545:Isoproterenol