No association of apolipoprotein epsilon 4 allele with schizophrenia even in cognitively impaired patients.
Given the strong association of the apolipoprotein E (apoE) allele epsilon 4 (epsilon 4) with Alzheimer's disease or cognitive decline in elderly, we tested whether cognitive performance in schizophrenic subjects is associated with an increase in the frequency of the ApoE epsilon 4 allele. Our data indicate that in our sample: (1) there is no association between schizophrenia and the ApoE epsilon 4 allele; and (2) the ApoE epsilon 4 allele is not of major importance with regard to the cognitive decline observed in schizophrenia.
Thibaut
F
F
Groupe de Recherche Psychopathologie et Schizophrenies (JE 2014), Universites de Medecine de Rouen et Caen, France.
Coron
B
B
Hannequin
D
D
Segard
L
L
Martin
C
C
Dollfus
S
S
Campion
D
D
Frebourg
T
T
Petit
M
M
D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*; D012565:Schizophrenic Psychology; D014888:Wechsler Scales
D001057:Apolipoproteins E; D005819:Genetic Markers