[The effect of the formulation of a skin cream with a procyanidin polymer base and its effect on skin lesions caused by herpesviruses].
Procyanidin polymers are reported to be virostatic and virucidal in vitro. In this experiment we showed, on a hairless mouse model, biological effects of these agents, already demonstrated in vitro on cell cultures. Several dermic cream compositions have been tested and compared for reduction of HSV1 cutaneous lesions. In this study, it appeared clearly that active principle dosage form is as important as the biological effect of the agent. Composition and water content influence permeation speed, contact time with surface skin layers and consequently the pharmacological effect on herpetic skin injuries.
Amouroux
P
P
Mu Laboratoire, ZAC du Pra de Serre, Veyre-Monton, France.
Jean
D
D
Lamaison
J L
JL
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D044946:Biflavonoids; D002392:Catechin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003874:Dermatitis Herpetiformis / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008812:Mice, Hairless; D009824:Ointments; D044945:Proanthocyanidins; D012867:Skin / Q000473:pathology*; D012869:Skin Absorption
D000998:Antiviral Agents; D044946:Biflavonoids; D009824:Ointments; D044945:Proanthocyanidins; C017674:procyanidin; D002392:Catechin