title: [Osteosonography of the phalanges of men].
abstract: BACKGROUND
  The distal metaphysis of the first phalanx of the fingers II to V is, like the vertebral body, a useful site for the measurement of mineralisation and structure of the bone, because of the simultaneous presence of compact and trabecular bone.
  
  
  METHODS
  With an osteosonographic device (DBM sonic 1200, IGEA, Italy) we measured in 38 young and healthy men, 14 elderly and healthy men, 18 men with osteopenia, 8 men with osteoporosis and vertebral fractures and 10 men with long-standing cortisone medication, the adSOS (amplitude-dependent speed of sound) and the UBPS (ultrasound bone profile score) at the phalanges, as well as bone mineral density (BMD) at lumbar spine using dual-X-ray absorptiometry (DXA).
  
  
  RESULTS
  There was no correlation between adSOS or UBPS and lumbar BMD (DXA). There was a significant positive correlation between adSOS and UBPS, r = 0.826 (p < 0.00001). AdSOS declined with age (r = 0.694, p = 0.021); the UBPS was not age-dependent (r = -0.15, p = n.s.), as expected. AdSOS and UBPS could discriminate significantly between the young and healthy controls and the men with osteopenia/vertebral fractures or oral steroids (p < 0.00001). The DXA could be significantly discriminate all healthy controls from the patients with osteopenia or vertebral fractures. It could not significantly discriminate the healthy controls from the patients taking oral glucoconticoids. Only the UBPS could significantly discriminate this group from the healthy controls.
  
  
  CONCLUSIONS
  These results show, that adSOS and UBPS are precise parameters to be measured at the phalanges. The detection level of pathological changes in osteoporosis are similar between adSOS and lumbar BMD (DXA) and improved by using UBPS. This might be explained by the influence of structural changes in bone on UBPS, rather than changes in bone mineral alone. Prospective studies have to clarify the role of adSOS and UBPS in fracture prediction.
authors.affiliation: Innere Medizin I, Endokrinologie und Stoffwechsel, Krehl-Klinik, Heidelberg.
authors.forename: T
authors.initials: T
authors.lastname: Soballa
authors.forename: J
authors.initials: J
authors.lastname: Schlegel
authors.forename: R
authors.initials: R
authors.lastname: Cadossi
authors.forename: R
authors.initials: R
authors.lastname: Isani
authors.forename: P
authors.initials: P
authors.lastname: Heilmann
authors.forename: R
authors.initials: R
authors.lastname: Ziegler
authors.forename: C
authors.initials: C
authors.lastname: Wüster
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D005385:Fingers / Q000000981:diagnostic imaging*; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000209:etiology; D012307:Risk Factors; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000209:etiology; D014463:Ultrasonography