Effect of intratympanic steroid application on the development of experimental cholesteatoma.
By introducing certain irritants into the middle ear it is possible to produce cholesteatoma. Propylene glycol, the main agent used for this purpose, produces a long-standing inflammation that causes hyperplasia and migration of the epithelium through an intact tympanic membrane. In the present investigation topical prednisolone was used in order to inhibit the production of cholesteatoma. The results indicate that there is a marked decrease in inflammation and hence experimental cholesteatoma production when prednisolone is administered into the middle ear.
Sennaroglu
L
L
Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Ozkul
A
A
Gedikoglu
G
G
Turan
E
E
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002465:Cell Movement; D018424:Cholesteatoma, Middle Ear / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004432:Ear, Middle; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005355:Fibrosis; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006097:Granulation Tissue / Q000187:drug effects / Q000473:pathology; D006965:Hyperplasia; D007249:Inflammation; D007267:Injections; D007509:Irritants / Q000009:adverse effects; D007633:Keratins / Q000187:drug effects; D010033:Otitis Media / Q000139:chemically induced / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D019946:Propylene Glycol / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D013701:Temporal Bone / Q000187:drug effects / Q000473:pathology; D014432:Tympanic Membrane / Q000187:drug effects / Q000473:pathology
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D007509:Irritants; D007633:Keratins; D019946:Propylene Glycol; D011239:Prednisolone