title: Immunohistochemistry of bone-marrow biopsy.
abstract: In a percentage of cases, conventional morphologic evaluation of bone-marrow needle biopsy (BMNB) in insufficient to achieve a firm diagnosis. Under these circumstances, immunohistochemistry plays a basic role, providing an easy and objective key for the interpretation of the pattern observed in most instances. Herein, the authors focus on the technical procedures, which allow extensive application of immunohistochemistry to the study of BMNB, as well as on the panels of antibodies needed for the identification of the most relevant conditions.
authors.affiliation: Second Service of Pathologic Anatomy/Unit of Haematopathology, Bologna University, S. Orsola Hospital, Italy. pileri@almadns.unibo.it
authors.forename: S A
authors.initials: SA
authors.lastname: Pileri
authors.forename: G
authors.initials: G
authors.lastname: Roncador
authors.forename: C
authors.initials: C
authors.lastname: Ceccarelli
authors.forename: M
authors.initials: M
authors.lastname: Piccioli
authors.forename: E
authors.initials: E
authors.lastname: Sabattini
authors.forename: A
authors.initials: A
authors.lastname: Briskomatis
authors.forename: D
authors.initials: D
authors.lastname: Santini
authors.forename: O
authors.initials: O
authors.lastname: Leone
authors.forename: P P
authors.initials: PP
authors.lastname: Piccaluga
authors.forename: L
authors.initials: L
authors.lastname: Leoncini
authors.forename: B
authors.initials: B
authors.lastname: Falini
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood*; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000737:chemistry* / Q000473:pathology; D019337:Hematologic Neoplasms / Q000378:metabolism / Q000473:pathology*; D006689:Hodgkin Disease / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000378:metabolism / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000378:metabolism / Q000473:pathology
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor