title: Experimental model of multidirectional disc hernia in rats.
abstract: We have carried out an experimental investigation of lesions of the intervertebral disc produced by flexion, lateral bending and rotational forces in an attempt to produce disc herniations. Adult Wistar rats were divided into 4 groups: control and posterior, lateral and rotational herniation. There were 10 rats in each group. The tail between the 5th and 8th vertebral segments was used. A Kirschner wire was inserted into each of 2 adjacent vertebrae and the movement produced had an apex which was anterior or lateral depending on the group involved. Variables such as rupture of the annulus, the cellularity of the nucleus pulposus and the site of the lesion in the disc were studied histologically. The height of the disc, the protrusion, the thickness, and the surfaces of the annulus fibrosus and the nucleus pulposus were measured. In every case we found a nuclear displacement which did not become a protrusion. The surface parameters and the cellularity of the nucleus pulposus are most useful indicators and should be included in any study examining the disc after the injection of substances for treatment.
authors.affiliation: Service of Traumatology and Orthopaedic Surgery, University Clinic Hospital, Zaragoza, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Latorre
authors.forename: J
authors.initials: J
authors.lastname: Albareda
authors.forename: T
authors.initials: T
authors.lastname: Castiella
authors.forename: J M
authors.initials: JM
authors.lastname: Lasierra
authors.forename: F
authors.initials: F
authors.lastname: Seral
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007405:Intervertebral Disc Displacement / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar