title: Soluble (s) CD14 and plasmatic lipopolysaccharides (LPS) in patients with chronic hepatitis C before and after treatment with interferon (IFN)-alpha.
abstract: CDI4 is a monocyte/polymorphonuclear cell receptor for lipopolysaccharide (LPS)-LPS Binding Protein (LBP), which mediates most of the toxic effects exerted by such a bacterial component in the host. Here, we provide evidence that sCD14 and interferon (IFN)-gamma serum levels are significantly higher in chronic hepatitis C (CH-C) patients than those detected in normal donors. On the other hand, CD4+/CD8+ antibacterial activity is depressed, thus facilitating entry of bacteria into the host. Of note, all these immune parameters are not modified by in vivo IFN-alpha administration over a period of one year. Finally, after 12 months of IFN-alpha treatment number of CH-C patients with detectable levels of plasmatic LPS increased, thus indicating a continuous release of LPS into the host and also suggesting a putative pathogenetic role for sCD14 LPS-LBP complex in subjects affected by CH-C virus infection.
authors.affiliation: I.R.C.C.S. S. de Bellis, Laboratory of Immunopathology, Castellana Grotte (Bari).
authors.forename: E
authors.initials: E
authors.lastname: Jirillo
authors.forename: L
authors.initials: L
authors.lastname: Amati
authors.forename: L
authors.initials: L
authors.lastname: Caradonna
authors.forename: B
authors.initials: B
authors.lastname: Greco
authors.forename: R
authors.initials: R
authors.lastname: Cozzolongo
authors.forename: R
authors.initials: R
authors.lastname: Cuppone
authors.forename: G
authors.initials: G
authors.lastname: Piazzolla
authors.forename: D
authors.initials: D
authors.lastname: Caccavo
authors.forename: S
authors.initials: S
authors.lastname: Antonaci
authors.forename: O G
authors.initials: OG
authors.lastname: Manghisi
mesh_terms: D000328:Adult; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008070:Lipopolysaccharides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016898:Interferon-alpha; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides