Primitive neuroectodermal tumor in a two-month-old black and white Colobus monkey.
A 2-month-old male black and white Colobus monkey (Colobus guereza kikuyuensis) was euthanatized because of progressive physical deterioration, rear limb paralysis, lymphadenopathy, and the presence of facial and retroperitoneal lumbar masses. At necropsy, soft white masses were present in and around lumbar vertebrae, the subcutis of the face, multiple lymph nodes, and the fourth ventricle of the brain. Histologic and immunohistochemical analysis of these masses revealed a primitive neoplasm with both neuronal and glial differentiation, consistent with a primitive neuroectodermal tumor (PNET) with bipotential differentiation. The extracranial tumors were synaptophysin (SYN)-positive, glial fibrillary acidic protein (GFAP)-negative, and neurofilament protein (NFP)-negative, while the intracranial tumor was SYN-positive, GFAP-positive, and NFP-negative.
Long
P H
PH
The Procter & Gamble Company, Cincinnati, OH 45242-1434, USA. longph@pg.com
Schulman
F Y
FY
Koestner
A
A
Fix
A S
AS
Campbell
M K
MK
Cameron
K N
KN
D000818:Animals; D000836:Animals, Zoo; D015415:Biomarkers / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D003104:Colobus; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D008297:Male; D008992:Monkey Diseases; D017599:Neuroectodermal Tumors / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D016900:Neurofilament Proteins / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D016708:Synaptophysin