Tubulin immunopositive structures resembling intracellular neurofibrillary tangles.
Tau protein promotes microtubule assembly. When aberrantly phosphorylated, it forms the core of neurofibrillary tangles (NFTs). We investigated by immunohistochemistry whether microtubules might also be involved in NFT formation. We found beta-tubulin immunoreactive NFT-like structures in Alzheimer disease, and, more frequently, in the parkinsonism dementia complex of Guam (bodig disease) and Down Syndrome. The beta-tubulin immunoreactive structures were intracellular and appeared at an early stage of tangle development. This may indicate an involvement of tubulin in NFT formation.
Schwab
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Kinsmen Laboratory of Neurological Research and the Neurodegenerative Disorders Centre, University of British Columbia, Vancouver, Canada.
McGeer
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PL
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D003704:Dementia / Q000378:metabolism / Q000473:pathology; D004314:Down Syndrome / Q000378:metabolism / Q000473:pathology; D006141:Guam; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000378:metabolism* / Q000473:pathology*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology; D014404:Tubulin / Q000378:metabolism*; D016875:tau Proteins / Q000378:metabolism
D014404:Tubulin; D016875:tau Proteins