[Controlled release using temperature-responsive poly(N-isopropylacrylamide) gel].
Poly (N-isopropylacrylamide) (PNIPAAm) gels were found to undergo discontinuous swelling-deswelling changes in response to a limited alteration in external temperatures. By utilizing such as thermosensitive characteristic of the PNIPAAm gel, controlled drug release was studied extensively. Drug release profiles were well established in connection with the temperature dependence of swelling ratio for the gel. The thermal regulation of the swelling degree of the gel made it possible for us to design several ways for performing a unique drug release profile such as a "pulsatile" or "on-off" release of indomethacin. Attempts to develop a more excellent drug release system have being made through studies of molecular design and synthesis for PNIPAAm-based thermosensitive gels.
Yoshida
R
R
Institute of Applied Biochemistry, University of Tsukuba.
D000178:Acrylamides; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005782:Gels; D013696:Temperature
D000178:Acrylamides; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; C067295:N-isopropylacrylamide