title: [Propofol for anesthesia and short-term sedation. The final word on use in children under three years].
abstract: Since its introduction in clinical use more than ten years ago, propofol is well appreciated for sedation and supplemental hypnosis in anaesthesia. However the substance is approved only for anaesthesia in children elder than three years. As can be substantiated by many data reported in literature, there are no pharmacokinetic or pharmacodynamic reasons whatsoever to withhold propofol from the younger children; this applies both to the use as a narcotic supplement and as a short term hypnotic for diagnostic and therapeutic interventions.
authors.affiliation: Klinik für Anästhesiologie und operative Intensivmedizin, Klinikum Kreis Herford, Herford.
authors.forename: P
authors.initials: P
authors.lastname: Reinhold
authors.forename: G
authors.initials: G
authors.lastname: Kraus
authors.forename: E
authors.initials: E
authors.lastname: Schlüter
mesh_terms: D018686:Anesthetics, Intravenous / Q000009:adverse effects / Q000493:pharmacokinetics; D002675:Child, Preschool; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000493:pharmacokinetics; D007223:Infant; D015742:Propofol / Q000009:adverse effects / Q000493:pharmacokinetics
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D015742:Propofol