title: Green light is effective and less painful than red light in photodynamic therapy of facial solar keratoses.
abstract: Photodynamic therapy (PDT) with topically applied delta-aminolevulinic acid (ALA) is increasingly employed to treat patients with multiple solar keratoses and superficial skin tumors. For these indications, ALA-PDT has been shown to be highly efficient. Treatment of multiple or extended lesions, however, is substantially hampered by the fact that ALA-PDT is associated with burning pain during the irradiation procedure. The standard irradiation devices commonly used for ALA-PDT emit red light around 630 nm. In the present half-side comparison study we have observed that ALA-PDT employing a green light irradiation device (543-548 nm) is equally effective, as compared with standard red light ALA-PDT. In contrast to red light ALA-PDT, however, green light ALA-PDT caused only little tingling and burning but no pain. These observations indicate that green light ALA-PDT is superior to standard ALA-PDT, because it is associated with less unwanted side effects.
authors.affiliation: Department of Dermatology, Heinrich Heine University Duesseldorf, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Fritsch
authors.forename: H
authors.initials: H
authors.lastname: Stege
authors.forename: G
authors.initials: G
authors.lastname: Saalmann
authors.forename: G
authors.initials: G
authors.lastname: Goerz
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
authors.forename: J
authors.initials: J
authors.lastname: Krutmann
mesh_terms: D000368:Aged; D000622:Aminolevulinic Acid / Q000627:therapeutic use; D006801:Humans; D007642:Keratosis / Q000188:drug therapy* / Q000209:etiology; D008027:Light / Q000009:adverse effects; D010146:Pain / Q000209:etiology; D010778:Photochemotherapy / Q000009:adverse effects* / Q000379:methods; D013472:Sunlight / Q000009:adverse effects*
chemical_list: D000622:Aminolevulinic Acid