Translocation t(1;10) (q21;q26) in a case of acute nonlymphocytic leukemia.
Chromosome banding studies carried out on bone marrow cells from a 16 year-old boy with an M1 acute nonlymphocytic leukemia (ANLL) revealed an unbalanced translocation involving chromosomes 1 and 10: der(10) t(1;10) (q21;q26) that results in a partial trisomy 1q between bands 1q21-1qter. Marker del(6)(q21) and trisomies of chromosomes 18, 21 and 22 were also observed. To our knowledge, this der(10) is the first to be reported in a patient with ANLL.
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Servicio de Anatomia Patológica, Hospital Neuropsiquiátrico Especializado Dr. Alejandro Korn, Melchor Romero, La Plata, Argentina. postmaster@anmra.sld.ar
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D000293:Adolescent; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy