Further pharmacological study on Sho-seiryu-to as an antiallergic.
Examination was made of the pharmacological characteristics of Sho-seiryu-to, an antiallergic kampo medicine. Sho-seiryu-to suppressed histamine release from rat peritoneal mast cells, but failed to inhibit the binding of [3H]-mepyramine to histamine H1 receptors in guinea pig cerebral cortex and lung. Sho-seiryu-to had no effect on cutaneous reactions induced by serotonin, platelet-activating factor (PAF), leukotriene (LT) C4 or LTD4. Ketotifen prolonged electrically induced convulsions, while Sho-seiryu-to did not. Sho-seiryu-to did not affect salivation induced by pilocarpine. Sho-seiryu-to thus does not appear to inhibit histamine H1 receptors or inflammation induced by serotonin, PAF, LTC4 and LTD4, but suppresses mast cell activity. Sho-seiryu-to would thus have only a few side effects such as dry mouth and convulsions due mainly to the blockage of the action of muscarinic in salivary glands and histamine in the brain.
Sakaguchi
M
M
Central Research Laboratories, Tsumura & Co., Ibaraki, Japan.
Mase
A
A
Iizuka
A
A
Yuzurihara
M
M
Ishige
A
A
Amagaya
S
S
Komatsu
Y
Y
Takeda
H
H
Matsumiya
T
T
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000276:immunology; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology; D010862:Pilocarpine / Q000037:antagonists & inhibitors; D011738:Pyrilamine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D011969:Receptors, Histamine H1 / Q000378:metabolism; D012472:Salivation / Q000187:drug effects; D012882:Skin Tests; D014316:Tritium
D004365:Drugs, Chinese Herbal; D006634:Histamine H1 Antagonists; D011969:Receptors, Histamine H1; C090832:sho-seiryu-to; D010862:Pilocarpine; D014316:Tritium; D011738:Pyrilamine