title: Fine needle aspiration biopsy of recurrent and metastatic osteosarcoma.
abstract: OBJECTIVE
  To assess the utility of fine needle aspiration (FNA) biopsy in evaluating local recurrence or disseminated metastases in patients with osteosarcoma.
  
  
  METHODS
  Cytology files from Saint Louis University Hospital and Indiana University Medical Center were searched for patients with osteosarcoma who had undergone FNA biopsy for evaluation of local recurrence or disseminated metastases. Clinical information was collected and all aspirate smears reviewed.
  
  
  RESULTS
  Six FNA biopsies in five patients were procured by either the percutaneous or radiologically guided method. All six aspirates were diagnostic. Cytologic features showed a discohesive, cellular neoplasm with intermediate to large cells and oval to spindle nuclei. Chromatin was coarsely granular, with single or multiple nucleoli. Aspirate material included multinucleated giant cells and a variable amount of "osteoidlike" extracellular matrix.
  
  
  CONCLUSIONS
  FNA biopsy is accurate, and these results reflect its ability to diagnose osteosarcoma when there is local recurrence or widely disseminated metastases.
authors.affiliation: Department of Pathology, Saint Louis University School of Medicine, Missouri, USA.
authors.forename: B T
authors.initials: BT
authors.lastname: Collins
authors.forename: H M
authors.initials: HM
authors.lastname: Cramer
authors.forename: R R
authors.initials: RR
authors.lastname: Ramos
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012516:Osteosarcoma / Q000473:pathology* / Q000556:secondary*; D010386:Pelvic Neoplasms / Q000473:pathology