Preventive effects of selenium-enriched spiruline (SESP) on radiation pneumonitis.
We studied the early effects of selenium-enriched spiruline (SESP) on radiation-induced pulmonary fibrosis using histopathology, cDNA-mRNA dot-blot hybridization, and a biochemical technique for quantifying the hydroxyproline content. We found marked lung injury in the irradiated group, whereas only slight hyperemia, hemorrhage, exudation, and thickness of the interalveolar wall in the lung in the selenium-treated group. The hydroxyproline (hyp) content in the lungs and the synthesis of type III collagen mRNA decreased in the SESP-treated group. Selenium-enriched spiruline may have a protective effect on the development of radiation pneumonitis.
Bai
Y
Y
Wang
D
D
Cui
X
X
Yang
Z
Z
Zhu
M
M
Zhang
Z
Z
Xia
G
G
Gong
Y
Y
D000818:Animals; D018076:DNA, Complementary / Q000032:analysis; D006909:Hydroxyproline / Q000032:analysis; D015151:Immunoblotting; D008168:Lung / Q000737:chemistry / Q000473:pathology / Q000528:radiation effects; D008297:Male; D009693:Nucleic Acid Hybridization; D010940:Plant Proteins / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000032:analysis; D017564:Radiation Pneumonitis / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000627:therapeutic use*
D018076:DNA, Complementary; D010940:Plant Proteins; D012333:RNA, Messenger; D012643:Selenium; D006909:Hydroxyproline