title: All wrapped up.
abstract: How is it possible that nine small repeated 'zinc finger' units (each spanning just 3 or 4 base pairs) can protect the whole 50 base pair binding site of TFIIIA and why should such a periodic protein structure give rise to such an asymmetric footprint on DNA? The crystal structure of the first six fingers of TFIIIA bound to 31 base pairs of DNA explains everything: not all zinc fingers act alike.
authors.forename: Y
authors.initials: Y
authors.lastname: Choo
authors.forename: J W
authors.initials: JW
authors.lastname: Schwabe
mesh_terms: D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D012341:RNA, Ribosomal, 5S / Q000235:genetics; D035561:Transcription Factor TFIIA; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism*; D014981:Xenopus; D016335:Zinc Fingers
chemical_list: D012341:RNA, Ribosomal, 5S; D035561:Transcription Factor TFIIA; D014157:Transcription Factors; D004247:DNA