Is topical tretinoin safe during the first trimester?
QUESTIONOne of my patients conceived while using a topical tretinoin preparation for acne. I know this drug is related to Accutane, which is teratogenic. How should I advise her?ANSWERAvailable evidence suggests that topical tretinoin does not increase teratogenic risk in humans.
Shapiro
L
L
Hospital for Sick Children, Toronto.
Pastuszak
A
A
Curto
G
G
Koren
G
G
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000152:Acne Vulgaris / Q000188:drug therapy*; D000279:Administration, Cutaneous; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D014212:Tretinoin / Q000009:adverse effects*
D007641:Keratolytic Agents; D014212:Tretinoin