title: Prediction of 7 months methadone maintenance treatment response by four measures of antisociality.
abstract: Zero-order correlational and simultaneous regression analyses were performed to ascertain the comparative validity of four measures of antisociality for predicting the initial 7 months treatment response of 193 male methadone maintenance (MM) patients. Predictor variables were the number of childhood conduct disorder (CD) behaviors, number of adult antisocial personality disorder (A-APD) behaviors, the revised Psychopathy Checklist (PCL-R) score and the revised California Psychological Inventory-Socialization (CPI-So) scale score. The outcome measures were completion/noncompletion of 7 months of treatment, percent positive during-treatment of cocaine, opiate and benzodiazepine urine toxicologies, and change from baseline to 7 months follow-up in seven Addiction severity index (ASI) composite scores (CSs). All four measures of antisociality were significantly correlated with treatment noncompletion, although only the PCL-R score was significant in the predictor model. The PCL-R predicted more positive cocaine urines. At the individual level, both PCL-R and CPI-So were associated with more positive benzodiazepine urines, but neither contributed a significant amount of variance when both were entered in the model. None of the predictors were significantly associated with self reported improvement in the CSs. The PCL-R and CPI-So were more successful in predicting outcomes than the two behavior-based measures.
authors.affiliation: University of Pennsylvania, School of Medicine, Treatment Research Center, Philadelphia 19104, USA. Internnet.Alterman@Research.TRC.UPenn.Edu
authors.forename: A I
authors.initials: AI
authors.lastname: Alterman
authors.forename: M J
authors.initials: MJ
authors.lastname: Rutherford
authors.forename: J S
authors.initials: JS
authors.lastname: Cacciola
authors.forename: J R
authors.initials: JR
authors.lastname: McKay
authors.forename: C R
authors.initials: CR
authors.lastname: Boardman
mesh_terms: D000328:Adult; D000987:Antisocial Personality Disorder / Q000150:complications / Q000175:diagnosis*; D001569:Benzodiazepines / Q000652:urine; D003042:Cocaine / Q000652:urine; D019955:Conduct Disorder / Q000175:diagnosis; D017831:Diagnosis, Dual (Psychiatry) / Q000379:methods / Q000592:standards; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D009294:Narcotics / Q000627:therapeutic use* / Q000652:urine; D009293:Opioid-Related Disorders / Q000150:complications / Q000175:diagnosis / Q000534:rehabilitation / Q000652:urine; D010352:Patient Dropouts; D010556:Personality Tests / Q000592:standards*; D011594:Psychometrics / Q000592:standards*; D012044:Regression Analysis; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D009294:Narcotics; D001569:Benzodiazepines; D003042:Cocaine; D008691:Methadone