title: Cerebral vasculitis during FK 506 treatment in a liver transplant patient.
abstract: The immunosuppressive agent FK 506 is widely used in liver transplant patients. Neurotoxicity is a major complication of its use. We report progressive and irreversible neurologic complications occurring in a 39-year-old woman who underwent liver transplantation and was treated with FK 506. Neuropathologic examination revealed multiple vasculitic lesions. The possibility of an FK 506-mediated toxic effect on the cerebral vessels is suggested.
authors.affiliation: Division of Clinical Pathology, Geneva University Hospital, Switzerland.
authors.forename: G P
authors.initials: GP
authors.lastname: Pizzolato
authors.forename: R
authors.initials: R
authors.lastname: Sztajzel
authors.forename: K
authors.initials: K
authors.lastname: Burkhardt
authors.forename: M
authors.initials: M
authors.lastname: Megret
authors.forename: B
authors.initials: B
authors.lastname: Borisch
mesh_terms: D000328:Adult; D002536:Cerebral Arteries / Q000473:pathology*; D002560:Cerebrovascular Circulation; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000633:toxicity*; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging; D009498:Neurotoxins / Q000009:adverse effects; D016559:Tacrolimus / Q000633:toxicity*; D014657:Vasculitis / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D007166:Immunosuppressive Agents; D009498:Neurotoxins; D016559:Tacrolimus