title: Na+/H+ exchange inhibition improves post-transplant myocardial compliance in 4-hour stored donor hearts.
abstract: Na+/H+ exchange inhibitors have cardioprotective properties. The effects of the new Na+/H+ exchange inhibitor, HOE642 on myocardial function were assessed after transplantation of canine brain-dead and non-brain-dead donor hearts preserved for 4 h. Four groups were studied: brain-dead donors; non-brain-dead donors; brain-dead donors and recipients treated with HOE642 (2 mg/kg); and treated non brain-dead donors and recipients. Donor hearts were stored in NIH2. At the end of 60 min reperfusion after transplantation, pressure-volume curves were constructed. Biopsies were analysed histologically and ultrastructurally. Afterwards, weaning from cardiopulmonary bypass was accomplished. HOE642 improved compliance in hearts from both brain-dead and non-brain-dead donors. No differences in myocardial water content nor in myocardial performance were detected. No irreversible damage was seen ultrastructurally. It is concluded that myocardial compliance after transplantation was improved by administration of HOE642. The use of this inhibitor might improve the current myocardial preservation technique for transplantation.
authors.affiliation: Centre for Experimental Surgery and Anaesthesiology, Katholieke Universiteit Leuven, Belgium.
authors.forename: Y I
authors.initials: YI
authors.lastname: Kim
authors.forename: P
authors.initials: P
authors.lastname: Herijgers
authors.forename: A
authors.initials: A
authors.lastname: Van Lommel
authors.forename: E
authors.initials: E
authors.lastname: Verbeken
authors.forename: W
authors.initials: W
authors.lastname: Flameng
mesh_terms: D000818:Animals; D001926:Brain Death; D004285:Dogs; D006146:Guanidines / Q000627:therapeutic use*; D006321:Heart; D016027:Heart Transplantation / Q000502:physiology*; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009926:Organ Preservation / Q000379:methods; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors*; D013450:Sulfones / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D006146:Guanidines; D017923:Sodium-Hydrogen Exchangers; D013450:Sulfones; C093373:cariporide