Relationship between muscle tone changes, sawtooth waves and rapid eye movements during sleep.
'Sawtoothed' waves occur during rapid eye movement (REM) sleep, but their source as well as their function is not known. We studied the onset of sawtooth waves (STW) in relation to the onset of muscle tone reduction (MTR) and to REM during 20 polysomnographic recordings in 11 normal volunteers. Seventy-seven (85%) of a total of 91 REM sleep cycles were used for further analysis, because within a 1000 s interval they showed a relatively stereotyped sequence of events: a generalized body movement, followed by MTR, then the appearance of STW, and ending with the first REM. The first STW often occurred during the electrographic stage II period prior to the beginning of the REM, by which time muscle tone was either already at or close to the tone level of the REM sleep period in all subjects. The overall mean onset time of MTR was 267 s (range 89-660 s), STW was 378 s (range 169-779), and REM was 448 s (range 265-849); their differences were highly significant (F = 27.1, df 2,20, P < 0.001). Our data suggest that a predictable sequence of muscle tone reduction, then STW, and then REM, precedes the generally accepted onset of the REM sleep period, and may have implications for the redesignation of physiologic REM sleep onset.
Sato
S
S
EEG Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1404, USA. sato@helix.nih.gov
McCutchen
C
C
Graham
B
B
Freeman
A
A
von Albertini-Carletti
I
I
Alling
D W
DW
D000328:Adult; D001931:Brain Mapping; D004569:Electroencephalography / Q000706:statistics & numerical data*; D004576:Electromyography; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009129:Muscle Tonus / Q000502:physiology*; D010507:Periodicity; D017286:Polysomnography; D012895:Sleep, REM / Q000502:physiology*