title: Nefazodone: single versus twice daily dose.
abstract: This pilot study involved six men with major depression treated with nefazodone dosed either twice/day or once/day at bedtime. Depression was rated before nefazodone therapy and at 4 weeks by the self-report version of the Hamilton Depression Rating Scale. A simple 10-cm visual analog side effect scale for daytime drowsiness was completed at the latter time. Dosages of nefazodone were at least 400 mg/day. The results suggest that nefazodone given once/day at bedtime may be as effective as the currently accepted twice/day regimen, with less daytime drowsiness.
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, University of South Carolina, Dorn Veterans Hospital, Columbia 29209-1639, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Voris
authors.forename: G N
authors.initials: GN
authors.lastname: Shaurette
authors.forename: P S
authors.initials: PS
authors.lastname: Sebastian
authors.forename: L A
authors.initials: LA
authors.lastname: Will-Wallace
mesh_terms: D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage* / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines; D012647:Self-Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D014230:Triazoles / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D018687:Antidepressive Agents, Second-Generation; D010879:Piperazines; D014230:Triazoles; C051752:nefazodone