Angiogenesis in rheumatoid arthritis: pathogenic and clinical significance.
In summary, angiogenesis, the formation of new blood vessels, is important in leukocyte extravasation and thus the pathogenesis of RA. The outcome of neovascularization highly depends on the imbalance between angiogenic and angiostatic mediators produced in the rheumatoid synovium. Therefore, angiogenesis research is important for the understanding of the pathogenesis of inflammatory arthritis. In addition, existing and potential angiostatic drugs may be useful for future therapy of RA.
Szekanecz
Z
Z
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
Szegedi
G
G
Koch
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AE
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D015815:Cell Adhesion Molecules / Q000502:physiology; D018925:Chemokines / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000503:physiopathology
D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines; D006133:Growth Substances