title: A comparison of young and aged populations for the diphtheria and tetanus antitoxin titers in Japan.
abstract: The antitoxin levels for diphtheria and tetanus were measured with samples of a young group immunized with diphtheria-tetanus-acellular pertussis combined vaccine and those of an aged group, members of which had not received vaccination in their youth. In the young group members of which had already received basic immunization with diphtheria-tetanus-acellular pertussis combined vaccine, the levels of both antitoxins rose well after injection at 11 to 12 years old with diphtheria-tetanus combined toxoids and remained high until 20 years of age. In the aged group, more than 80% showed antitoxin levels above 0.01 u/ml for diphtheria, while all had levels below that for tetanus, except three persons with confirmed tetanus immunization history. Maintenance of the protective antitoxin levels in the population by vaccination is necessary to prevent outbreaks of infection among unvaccinated or only partially immunized persons.
authors.affiliation: Department of Bacterial and Blood Products, National Institute of Health, Tokyo.
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Komiya
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: Y
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: R
authors.initials: R
authors.lastname: Ishii
authors.forename: F
authors.initials: F
authors.lastname: Goshima
authors.forename: H
authors.initials: H
authors.lastname: Arimoto
authors.forename: H
authors.initials: H
authors.lastname: Kaku
authors.forename: N
authors.initials: N
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Goshima
authors.forename: T
authors.initials: T
authors.lastname: Katoh
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004166:Diphtheria Antitoxin / Q000097:blood*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000627:therapeutic use*; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D007564:Japan; D008875:Middle Aged; D013743:Tetanus Antitoxin / Q000097:blood*; D014611:Vaccination
chemical_list: D004166:Diphtheria Antitoxin; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D013743:Tetanus Antitoxin