[Comparative analysis of distribution of mutant alleles of the gene coding for the CCR-5 chemokine receptor, among people in Russia, infected and not infected with HIV-1].
Comparative analysis of the distribution of deletion mutations of CC-chemokine receptor 5 (CCR-5) gene among HIV-1 infected and not infected subjects in Russia showed the incidence of the heterozygous genotype to be 17.8% among both HIV-infected and seronegative subjects. The incidence of the homozygous genotype for the deletion among seronegative individuals was 0.6%, but no homozygotes were found among HIV-1 infected patients. Study of the incidence of the mutant CCR-5 allele among patients infected with different HIV-1 subtypes showed that the susceptibility of heterozygotes to HIV-1 infection was not associated with any special genetic subtype.
Kazennova
E V
EV
Aarons
E
E
Selimova
L M
LM
Ladnaia
N N
NN
Kravchenko
A V
AV
Zhemchugov
V E
VE
Chaingon-Popov
R
R
Weber
J
J
Pokrovskiĭ
V V
VV
Bobkov
A F
AF
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018023:HIV Seronegativity / Q000235:genetics*; D015497:HIV-1; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009154:Mutation; D019713:Receptors, CCR5 / Q000235:genetics*; D012426:Russia; D017384:Sequence Deletion
D019713:Receptors, CCR5