title: A new concept of drug delivery for acne.
abstract: Adapalene is a stable naphthoic acid derivative that displays a strong retinoid agonist pharmacology. This drug controls cell proliferation and differentiation, and possesses significant anti-inflammatory action. The retinoid action of adapalene are mediated by the ligand-activated gene transcription factors retinoic acid receptors RAR beta and RAR gamma. We describe here how an aqueous gel containing adapalene was selected for the topical treatment of acne.
authors.affiliation: CIRD Galderma, Sophia Antipolis, France.
authors.forename: B
authors.initials: B
authors.lastname: Shroot
authors.forename: S
authors.initials: S
authors.lastname: Michel
authors.forename: J
authors.initials: J
authors.lastname: Allec
authors.forename: A
authors.initials: A
authors.lastname: Chatelus
authors.forename: N
authors.initials: N
authors.lastname: Wagner
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000068816:Adapalene; D000287:Administration, Topical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002454:Cell Differentiation / Q000187:drug effects; D005782:Gels; D006801:Humans; D066298:In Vitro Techniques; D009281:Naphthalenes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012867:Skin / Q000378:metabolism / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D009281:Naphthalenes; D000068816:Adapalene