title: Treatment of acardiac twinning.
abstract: BACKGROUND
  The twin reversed-arterial-perfusion sequence is a complication of monochorionic twin pregnancies characterized by the hemodynamic dependence of a "recipient" twin from a "pump" twin. The recipient twin exhibits lethal abnormalities including acardia and acephaly. The pump twin has a mortality rate of 50% as a result of high-output heart failure.
  
  
  METHODS
  The blood supply to an acardiac-acephalus twin was interrupted at 24 weeks' gestation using endoscopic laser coagulation. The co-twin was delivered at 35 weeks and had an uneventful neonatal course following correction of a persistent patent ductus arteriosus. Review of the literature reveals 22 cases of acardiac twinning treated with invasive procedures, seven of them using endoscopic laser coagulation. Pump twin mortality with fetal surgery was 13.6% in comparison with 50% mortality with expectant management (P < .001).
  
  
  CONCLUSIONS
  Fetal surgery is the best available treatment for acardiac twinning. Endoscopic laser coagulation at or before 24 weeks and endoscopic or sonographic guided umbilical cord ligation after this gestational age seem to be the best treatments for this condition.
authors.affiliation: Department of Obstetrics and Gynecology, St. John's Mercy Medical Center, St. Louis, Missouri 63141, USA.
authors.forename: F
authors.initials: F
authors.lastname: Arias
authors.forename: S
authors.initials: S
authors.lastname: Sunderji
authors.forename: R
authors.initials: R
authors.lastname: Gimpelson
authors.forename: E
authors.initials: E
authors.lastname: Colton
mesh_terms: D009008:Abnormalities, Severe Teratoid / Q000000981:diagnostic imaging; D000328:Adult; D004200:Diseases in Twins; D005260:Female; D005315:Fetal Diseases; D006801:Humans; D007231:Infant, Newborn; D017075:Laser Coagulation; D011247:Pregnancy; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000601:surgery