title: Late endocrine effects of ovarian electrocautery in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To examine the duration of the changes in endocrine indices produced by ovarian electrocautery in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Long-term observational study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Infertile women with PCOS.
  
  
  METHODS
  Ovarian electrocautery was performed through the laparoscope. Blood was sampled before the operation and at defined intervals thereafter. After the establishment of regular cycles, sampling was performed 1 week before the menstrual period.
  
  
  METHODS
  The patients were observed before and at defined intervals for up to 20 years after ovarian electrocautery. Serum concentrations of hypophyseal and ovarian hormones were determined, including sex hormone-binding globulin (SHBG).
  
  
  RESULTS
  There was a clear shift from anovulation to ovulatory cycles and a significant decrease in androgens and gonadotropins. The concentration of SHBG increased. These effects lasted for many years; after 18-20 years, two thirds of the women were still ovulating.
  
  
  CONCLUSIONS
  Ovarian electrocautery for PCOS normalizes ovarian function, including androgen production, and the results seem to be stable for 18-20 years.
authors.affiliation: Department of Gynecology, Aker University Hospital, Oslo, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Gjønnaess
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood / Q000378:metabolism; D000328:Adult; D000735:Androstenedione / Q000097:blood / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood / Q000378:metabolism; D013196:Dihydrotestosterone / Q000097:blood / Q000378:metabolism; D004564:Electrocoagulation; D004958:Estradiol / Q000097:blood / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood* / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000097:blood* / Q000378:metabolism; D006801:Humans; D010535:Laparoscopy; D008137:Longitudinal Studies; D010060:Ovulation / Q000097:blood / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism / Q000601:surgery*; D011374:Progesterone / Q000097:blood / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000032:analysis / Q000378:metabolism; D013739:Testosterone / Q000097:blood / Q000378:metabolism; D013997:Time Factors
chemical_list: D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D019326:17-alpha-Hydroxyprogesterone