Evaluating motor end-plate-targeted injections of botulinum toxin type A in a canine model.
Tarsal joint forces were measured in dogs over 70 days following botulinum toxin type A (BTX-A) injections. Three dogs were injected at motor end-plates located by electromyography (EMG), while 3 dogs were similarly injected, but without EMG guidance. Extension forces were significantly (P < 0.05) smaller in limbs injected at motor end-plates than in corresponding limbs on days 14 and 35. There were no significant differences at other times. Using these techniques, EMG end-plate targeting potentiates effects of BTX-A.
Childers
M K
MK
Department of Physical Medicine and Rehabilitation, School of Medicine, University of Missouri-Columbia, 65212, USA.
Kornegay
J N
JN
Aoki
R
R
Otaviani
L
L
Bogan
D J
DJ
Petroski
G
G
D000818:Animals; D001905:Botulinum Toxins / Q000494:pharmacology*; D004285:Dogs; D004576:Electromyography; D007273:Injections, Intramuscular; D009045:Motor Endplate / Q000187:drug effects* / Q000502:physiology; D013643:Tarsus, Animal / Q000502:physiology
D001905:Botulinum Toxins