Biological effects of macrotetrolide antibiotics and nonactic acids.
Published results as well as patent applications on biological effects of macrotetrolides and nonactic acids are reviewed. Their antimicrobial, antiprotozoan (coccidiostatic), antiparasitic (anthelminthic), insecticidal and acaricidal (miticidal) effects and also newly described immunosuppressive and plant growth stimulating activities are described. Both theoretical papers and practical applications including the effects of macrotetrolides on the environment are included; a particular target organism and precise dosage (e.g. LD50) are reported, in agreement with the original papers. It appears that macrotetrolides and their homologs are very prospective bioactive compounds that find application in agriculture, forestry, human and veterinary medicine while their negative effects on the environment are restricted to a minimum (biological quality of soil and water etc.).
Zizka
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Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007306:Insecticides / Q000494:pharmacology; D018942:Macrolides; D008925:Mites / Q000187:drug effects / Q000648:ultrastructure; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D007166:Immunosuppressive Agents; D007306:Insecticides; D018942:Macrolides