Urinary excretion of aquaporin-2 in term and preterm infants.
Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel of the renal collecting duct and is excreted in human urine. We measured the urinary excretion of AQP-2 by radioimmunoassay in 14 term and 12 preterm infants aged 1 month. Excretion of AQP-2 was low compared with adults, and correlated significantly with urine osmolality in preterm infants. Our results demonstrate that AQP-2 water channels are expressed in the renal collecting duct of both term and preterm infants.
Tsukahara
H
H
Department of Pediatrics, Fukui Medical School, Japan.
Hata
I
I
Sekine
K
K
Miura
M
M
Hata
K
K
Fujii
Y
Y
Mayumi
M
M
D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D001127:Arginine Vasopressin / Q000652:urine; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000652:urine*; D007234:Infant, Premature / Q000652:urine*; D007473:Ion Channels / Q000652:urine*; D008297:Male; D009994:Osmolar Concentration; D011863:Radioimmunoassay; D012016:Reference Values; D014556:Urine
C496023:AQP2 protein, human; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D007473:Ion Channels; D001127:Arginine Vasopressin