Mads and Smads in TGF beta signalling.
The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases.
Attisano
L
L
Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada.
Wrana
J L
JL
D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D051785:Smad Proteins; D051898:Smad1 Protein; D015534:Trans-Activators; D016212:Transforming Growth Factor beta / Q000502:physiology*; D029867:Xenopus Proteins
D004268:DNA-Binding Proteins; C000607853:SMAD1 protein, Xenopus; D051785:Smad Proteins; D051898:Smad1 Protein; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D029867:Xenopus Proteins