Effect of hypohydration on gastric emptying and intestinal absorption during exercise.
Dehydration and hyperthermia may impair gastric emptying (GE) during exercise; the effect of these alterations on intestinal water flux (WF) is unknown. Thus the purpose of this study was to determine the effect of hypohydration ( approximately 2.7% body weight) on GE and WF of a water placebo (WP) during cycling exercise (85 min, 65% maximal oxygen uptake) in a cool environment (22 degrees C) and to also compare GE and WF of three carbohydrate-electrolyte solutions (CES) while the subjects were hypohydrated. GE and WF were determined simultaneously by a nasogastric tube placed in the gastric antrum and via a multilumen tube that spanned the duodenum and the first 25 cm of jejunum. Hypohydration was attained 12-16 h before experiments by low-intensity exercise in a hot (45 degrees C), humid (relative humidity 50%) environment. Seven healthy subjects (age 26.7 +/- 1.7 yr, maximal oxygen uptake 55.9 +/- 8.2 ml . kg-1 . min-1) ingested either WP or a 6% (330 mosmol), 8% (400 mosmol), or a 9% (590 mosmol) CES the morning following hypohydration. For comparison, subjects ingested WP after a euhydration protocol. Solutions ( approximately 2.0 liters total) were ingested as a large bolus (4.6 ml/kg body wt) 5 min before exercise and as small serial feedings (2.3 ml/kg body wt) every 10 min of exercise. Average GE rates were not different among conditions (P > 0.05). Mean (+/-SE) values for WF were also similar (P > 0.05) for the euhydration (15.3 +/- 1.7 ml . cm-1 . h-1) and hypohydration (18.3 +/- 2.6 ml . cm-1 . h-1) experiments. During exercise after hypohydration, water absorption was greater (P < 0.05) with ingestion of WP (18.3 +/- 2. 6) and the 6% CES (16.5 +/- 3.7), compared with the 8% CES (6.9 +/- 1.5) and the 9% CES (1.8 +/- 1.7). Mean values for final core temperature (38.6 +/- 0.1 degrees C), heart rate (152 +/- 1 beats/min), and change in plasma volume (-5.7 +/- 0.7%) were similar among experimental trials. We conclude that 1) hypohydration to approximately 3% body weight does not impair GE or fluid absorption during moderate exercise when ingesting WP, and 2) hyperosmolality (>400 mosmol) reduced WF in the proximal intestine.
Ryan
A J
AJ
Departments of Exercise Science and Internal Medicine, University of Iowa, Iowa City 52242, USA.
Lambert
G P
GP
Shi
X
X
Chang
R T
RT
Summers
R W
RW
Gisolfi
C V
CV
D000328:Adult; D001835:Body Weight; D003681:Dehydration / Q000503:physiopathology*; D004573:Electrolytes / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D005334:Fever / Q000503:physiopathology; D005632:Fructose / Q000493:pharmacokinetics; D005746:Gastric Emptying / Q000502:physiology*; D005947:Glucose / Q000493:pharmacokinetics; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D009994:Osmolar Concentration; D005082:Physical Exertion / Q000502:physiology*; D010953:Plasma Volume / Q000502:physiology; D013696:Temperature; D014867:Water / Q000008:administration & dosage / Q000378:metabolism
D004573:Electrolytes; D014867:Water; D005632:Fructose; D005947:Glucose