title: Effective diameters of ion channels formed by homologs of the antibiotic chrysospermin.
abstract: Radii of ion channels formed in the lipid bilayer by 4 homologs of the alamethicin-like antibiotic, chrysospermin, were determined using hydrophilic nonelectrolytes. It is shown that the replacement of isovaline amino acid at position 15 of the polypeptide chain by alpha-aminoisobutyric acid results in the decrease in the channel effective radius from 1.2 +/- 0.15 to 0.94 +/- 0.1 nm and a respective 2.5-fold decrease in channel conductance.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Ternovsky
authors.forename: P A
authors.initials: PA
authors.lastname: Grigoriev
authors.forename: G N
authors.initials: GN
authors.lastname: Berestovsky
authors.forename: R
authors.initials: R
authors.lastname: Schlegel
authors.forename: K
authors.initials: K
authors.lastname: Dornberger
authors.forename: U
authors.initials: U
authors.lastname: Gräfe
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000737:chemistry; D023181:Antimicrobial Cationic Peptides; D004553:Electric Conductivity; D007473:Ion Channels / Q000737:chemistry* / Q000648:ultrastructure; D008051:Lipid Bilayers / Q000737:chemistry; D008969:Molecular Sequence Data; D054848:Peptaibols; D010455:Peptides / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D007473:Ion Channels; D008051:Lipid Bilayers; D054848:Peptaibols; D010455:Peptides; C096629:chrysospermin A; C096630:chrysospermin B; C096631:chrysospermin C; C096632:chrysospermin D