title: Detection of suppression of bitterness by sweet substance using a multichannel taste sensor.
abstract: A multichannel taste sensor whose transducer is composed of several kinds of lipid/polymer membranes with different characteristics can detect taste in a manner similar to human gustatory sensation. Taste information is transformed into a pattern composed of electric signals of membrane potentials of the receptor part. In the present study, it was shown that the suppression of the bitterness of quinine and a drug substance by sucrose can be quantified using a multichannel taste sensor. The present method can be expected to provide a new automated method to measure the strength of bitterness of drug substance in the place of sensory evaluation.
authors.affiliation: the Department of Electronic Device Engineering, Graduate School of Information Science and Electrical Engineering, Kyushu University, Fukuoka 812, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takagi
authors.forename: K
authors.initials: K
authors.lastname: Toko
authors.forename: K
authors.initials: K
authors.lastname: Wada
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Toyoshima
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D004566:Electrodes; D008055:Lipids; D008564:Membrane Potentials; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011143:Polyvinyl Chloride; D011803:Quinine / Q000737:chemistry*; D013395:Sucrose / Q000737:chemistry*; D013549:Sweetening Agents / Q000737:chemistry*; D013649:Taste
chemical_list: D008055:Lipids; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D013549:Sweetening Agents; D013395:Sucrose; D011143:Polyvinyl Chloride; D011803:Quinine