Enhanced expression of interleukin-6 in bone and serum of metastatic renal cell carcinoma.
Interleukin-6 (IL-6) is produced by renal cell carcinoma (RCC) cell lines and primary tumors. Using immunohistochemical staining in two RCC patients with hypercalcemia and high serum levels of free and total IL-6, we showed expression of IL-6 in metastatic bone tissue. The role of IL-6 in hypercalcemia and bone resorption would suggest that bisphosphonates or dexamethasone could be useful as adjuvant therapy for IL-6 dependent bone metastases which fail to respond to interferon alpha (IFN) alpha 2a and all trans retinoic acid (ATRA).
Paule
B
B
Service de Rhumatologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
Clerc
D
D
Rudant
C
C
Coulombel
C
C
Bonhomme-Faivre
L
L
Quillard
J
J
Bisson
M
M
D001859:Bone Neoplasms / Q000150:complications / Q000378:metabolism* / Q000556:secondary; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000378:metabolism*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019947:Receptors, Interleukin-6 / Q000097:blood
D015850:Interleukin-6; D019947:Receptors, Interleukin-6