title: [Comparison of the clinical course of pneumonia and concentration of immunoglobulin in patients treated with a standard method and with the addition of gmma-venin P].
abstract: The therapy with immunoglobulin have been used since many years, although its clinical efficacy still is uncertain. The aim of this study was to compare the clinical course of severe pneumonia and concentration of immunoglobulin in patients admitted to the intensive care units (ICU). The patients were treated either with antibiotics only or with antibiotics and Gamma-Venin P. Investigates group consisted of 30 patients with severe pneumonia. 15 of them (group A) were treated with antibiotics only, and another 15 (group B) with antibiotics and Gamma-Venin P. Immunoglobulins were administrated intravenously in the maximum single dose 3.0 g/kg. The serum concentration of immunoglobulin were measured before and every second day after beginning of the treatment. 27 patients completed the study due to protocol (14 patients in group A and 13 patients in group B). Only two patients revealed sings of intolerance of Gamma-Venin P during the first infusion of immunoglobulin. The clinical course of pneumonia and duration of treatment in ICU were similar in both groups. Statistically significant differences in concentration of immunoglobulins in patients treated without immunoglobulin infusion in comparison with patients with Gamma-Venin P were not found. We conclude, that infusion of immunoglobulins did not improve the clinical course of the severe pneumonia.
authors.affiliation: II Katedra i Klinika Chorób Wewnetrznych Uniwersytetu Jagiellońskiego w Krakowie.
authors.forename: B
authors.initials: B
authors.lastname: Piotrowska
authors.forename: W
authors.initials: W
authors.lastname: Droszcz
authors.forename: A
authors.initials: A
authors.lastname: Radomyski
authors.forename: W
authors.initials: W
authors.lastname: Tomkowski
authors.forename: W
authors.initials: W
authors.lastname: Bodzoń
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000998:Antiviral Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000097:blood; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy*; D005719:gamma-Globulins / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D007136:Immunoglobulins; D005719:gamma-Globulins; C031151:pepsinated immunoglobulin G