[Evaluation of the eventual activity of cyclosporin A in preventing the transmission, by blood transfusion, of Trypanosoma cruzi infection].
Cyclosporin A has activity "in vitro" against trypomastigotes of Trypanosoma cruzi. We tried to evaluate, in an "in vitro" model, using variable concentrations in whole blood contaminated with known numbers of parasites and injecting this blood after a two hour incubation period in mice if it was possible to prevent infection. In this model the drug, in the concentrations used, was unable to prevent infection.
Amato Neto
V
V
Laboratório de Investigação Médica-Parasitologia do Hospital das Clínicas, da Faculdade de Medicina da Universidade de São Paulo.
Pasternak
J
J
de Souza
E R
ER
Costa
A M
AM
Matsubara
L
L
D000818:Animals; D001769:Blood / Q000469:parasitology*; D001803:Blood Transfusion; D014355:Chagas Disease / Q000517:prevention & control* / Q000635:transmission; D016572:Cyclosporine / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D014349:Trypanosoma cruzi / Q000187:drug effects*
D016572:Cyclosporine