[Immune thrombocytopenia attributed to norfloxacin].
A 65-year-old woman developed haemorrhagic diathesis due to a profound thrombocytopenia (thrombocyte count: 1 x 10(9)/l) within one week after a 10-day course of norfloxacin (2 x 400 mg/day), prescribed for cystitis. On account of increased megakaryopoiesis in the bone marrow and absence of other causes of thrombocytopenia norfloxacin-induced immune thrombocytopenia was diagnosed. No norfloxacin-dependent antibodies against platelets were detected. Treatment with prednisone (1.5 mg/kg/day) resulted in the normalization of the platelet count within 5 days.
Wensing
J W
JW
Diaconessenhuis, afd. Inwendige Geneeskunde, Eindhoven.
Vlasveld
L T
LT
D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000139:chemically induced*; D003556:Cystitis / Q000188:drug therapy; D005260:Female; D006474:Hemorrhagic Disorders / Q000209:etiology; D006801:Humans; D009643:Norfloxacin / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications / Q000276:immunology
D000890:Anti-Infective Agents; D009643:Norfloxacin