title: Endogenous monoamine oxidase A inhibitory activity (tribulin), measured in saliva, is related to cardiovascular reactivity in normal individuals.
abstract: Salivary monoamine oxidase A inhibitory activity (MAO-AI), mean arterial blood pressure (MAP) and heart rate (HR) were determined simultaneously in healthy male students (n = 13) at rest, before a mild psychological stressor, twice during the task and 18 minutes after the end of the task. The sample as a whole showed significant differences in MAP and HR across occasions (respectively, p < 0.001 for both). Salivary MAO-AI could distinguish novice and experienced game players (p < 0.02) and was consistently positively correlated with MAP (r = 0.58, p < 0.05 on occasion 2). Pre-task measures of MAO-AI for an increased sample (n = 18) were associated with higher MAP (but not HR) throughout the experiment (p < 0.05). Those subject with falling MAO-AI profiles from task to recovery showed significantly greater simultaneous decline in HR than those with a rising MAO-AI profile (p < 0.05).
authors.affiliation: Psychophysiology and Stress Research Group, University of Westminster, London, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Clow
authors.forename: A
authors.initials: A
authors.lastname: Doyle
authors.forename: F
authors.initials: F
authors.lastname: Hucklebridge
authors.forename: D
authors.initials: D
authors.lastname: Carroll
authors.forename: C
authors.initials: C
authors.lastname: Ring
authors.forename: J
authors.initials: J
authors.lastname: Shrimpton
authors.forename: G
authors.initials: G
authors.lastname: Willemsen
authors.forename: P D
authors.initials: PD
authors.lastname: Evans
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007510:Isatin; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000032:analysis* / Q000378:metabolism; D012016:Reference Values; D012463:Saliva / Q000737:chemistry* / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors; D018910:Video Games
chemical_list: D008996:Monoamine Oxidase Inhibitors; D007510:Isatin; C039776:tribulin