title: Positive and negative syndromes, and Borna disease virus infection in schizophrenia.
abstract: The relationship between Borna disease virus (BDV) infection and positive and negative syndromes in schizophrenia was investigated. By nested RT-PCR and Western blotting, BDV-specific RNA and anti-BDV antibodies were examined in blood from 67 schizophrenic patients (DSM-III-R) in Japan, and the psychometric properties of the Positive and Negative Syndrome Scale (PANSS) were analyzed. There were significant (p < 0.05) differences in the composite index denoting the positive minus negative difference indicating a dominant contribution by negative items, and the proportion of negative type (positive minus negative value below zero) patients, between patients positive and negative for anti-BDV p24 antibodies. It is possible that BDV infection with induction of BDV p24 antibodies may be associated with negative syndromes in schizophrenic patients.
authors.affiliation: Department of Neuropsychiatry, Kagawa Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwahashi
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Suwaki
authors.forename: T
authors.initials: T
authors.lastname: Nakaya
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Ikuta
mesh_terms: D000328:Adult; D001890:Borna Disease / Q000150:complications / Q000523:psychology*; D001891:Borna disease virus / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007564:Japan; D007902:Length of Stay; D008297:Male; D016133:Polymerase Chain Reaction; D011569:Psychiatric Status Rating Scales; D012367:RNA, Viral / Q000032:analysis / Q000737:chemistry; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology
chemical_list: D012367:RNA, Viral