Expression of the axon growth-related neural adhesion molecule TAG-1/axonin-1 in the adult mouse brain.
TAG-1/axonin-1 is a neuronal cell adhesion molecule of the immunoglobulin superfamily. It is predominantly expressed during neural development and has been reported to be involved in axonal growth and pathfinding. Here, the expression of TAG-1/axonin-1 was investigated anatomically in the adult mouse brain by in situ hybridization using digoxigenin-labeled cRNA probes. Low levels of TAG-1/axonin-1 could be detected in cerebellar granule cells, in tufted and mitral cells of the olfactory bulb, and in pyramidal cells of area CA1 and CA3 of the hippocampus. We suspect that the expression of TAG-1/axonin-1 in these structures of the adult brain may serve neural plasticity.
Wolfer
D P
DP
Department of Anatomy University of Zürich, Switzerland. dpwolfer@anatomie.unizh.ch
Giger
R J
RJ
Stagliar
M
M
Sonderegger
P
P
Lipp
H P
HP
D000818:Animals; D001923:Brain Chemistry; D015816:Cell Adhesion Molecules, Neuronal / Q000032:analysis*; D002531:Cerebellum / Q000737:chemistry; D058969:Contactin 2; D006624:Hippocampus / Q000737:chemistry; D017403:In Situ Hybridization; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D051379:Mice; D008813:Mice, Inbred ICR; D009473:Neuronal Plasticity / Q000502:physiology; D009830:Olfactory Bulb / Q000737:chemistry
D015816:Cell Adhesion Molecules, Neuronal; C548675:Cntn2 protein, mouse; D058969:Contactin 2; D008562:Membrane Glycoproteins