CaaX converting enzymes.
Proteins that contain a carboxyl-terminal CaaX motif undergo post-translational processing involving prenylation, endoproteolysis and methylesterification. Two yeast genes, AFC1 and RCE1, which are candidates for genes encoding CaaX converting enzymes, were recently identified. Rce1p is required for the full penetrance of the activated Ras2pval19 phenotype in yeast, indicating its possible utility as a new target in Ras-based malignancies. Advances in our current understanding of CaaX convertases and the functional importance of CaaX proteolysis are discussed.
Ashby
M N
MN
Acacia Biosciences Inc., Richmond, CA 94806, USA. ashbym@acaciabio.com
D000595:Amino Acid Sequence; D029681:Arabidopsis Proteins; D010450:Endopeptidases / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism*; D006868:Hydrolysis; D008666:Metalloendopeptidases; D008969:Molecular Sequence Data; D010675:Pheromones / Q000737:chemistry / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism*; D043484:Proprotein Convertases; D011494:Protein Kinases / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins
D029681:Arabidopsis Proteins; D005656:Fungal Proteins; D010675:Pheromones; D010940:Plant Proteins; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases; C090861:AFC1 protein, Arabidopsis; D010450:Endopeptidases; D043484:Proprotein Convertases; C105193:RCE1 protein, S cerevisiae; D008666:Metalloendopeptidases