title: Time course of chronic diazepam effects on the auditory evoked potential of the rat.
abstract: The time course of chronic diazepam effects on auditory evoked potentials was studied in rats. Auditory evoked potentials were elicited by background and target tones in a passive oddball paradigm. Diazepam was administered by slow release implants to establish constant blood concentrations. Recordings were made during 21 days of treatment and 9 days after treatment ceased. Diazepam increased the amplitude of the P40 component and decreased the amplitude of the P72-P102 components elicited by background tones. Diazepam increased the amplitude of the P40-P48 component and decreased that of the N58 component elicited by target tones. These effects remained constant during treatment. Diazepam further decreased the amplitude of the P102 component elicited by target tones. This effect became more distinct over time. No group differences were found 9 days after treatment. The constant drug effects on middle-latency components (P40-P48) might reflect diazepam-induced changes in sensory information processing. The decreased long-latency component (P102) might reflect a diminished attention to, or discrimination of, target tones. The time course of this effect might reflect diazepam-enhanced habituation.
authors.affiliation: NICI, Department of Experimental Anesthesiology, University of Nijmegen, The Netherlands.
authors.forename: M L
authors.initials: ML
authors.lastname: Jongsma
authors.forename: C M
authors.initials: CM
authors.lastname: Van Rijn
authors.forename: E A
authors.initials: EA
authors.lastname: De Bruin
authors.forename: R
authors.initials: R
authors.lastname: Dirksen
authors.forename: A M
authors.initials: AM
authors.lastname: Coenen
mesh_terms: D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004361:Drug Tolerance; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D003975:Diazepam