[Is the detection of familial hypercholesterolemia in children indicated? Occasionally, yes].
Searching for familial hypercholesterolaemia (FH) in children is useful only if efficacious treatment is to be administered shortly and if there are relatives with ischaemic heart disease at very early ages. In all other cases, the (psychological) drawbacks probably outweigh the doubtful benefit of early intervention. The search for the major homozygous form of FH begins with cholesterol assay in both parents, in the absence of FH in either of them, the above-named restrictions apply.
Gevers Leuven
J A
JA
TNO Preventie en Gezondheid, Gaubiuslaboratorium, Leiden.
D000293:Adolescent; D002648:Child; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D018752:Diet, Fat-Restricted / Q000523:psychology; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000178:diet therapy / Q000523:psychology; D013315:Stress, Psychological
D008078:Cholesterol, LDL; D002784:Cholesterol