Relationship among risk factors of atherosclerosis, leukocyte count, and soluble intercellular adhesion molecule-1.
We investigated the effects of risk factors of atherosclerosis on soluble intercellular adhesion molecule-1 (sICAM-1) concentration and leukocyte count by using multivariate statistical analysis. The subjects were 90 people who were hospitalized for a complete check-up examination. Eight risk factors were selected as candidates for predictor variables: age, body mass index (BMI), uric acid, glycohemoglobin A1c, number of cigarettes smoked daily, total cholesterol, triglyceride, and high density lipoprotein (HDL)-cholesterol. The predictor variables were selected using a stepwise method, [criterion variable - predictor variable (standardized regression coefficient)]; sICAM1 - age (0.1859), number of cigarettes (0.2558), triglyceride (0.2447); leukocytes - number of cigarettes (0.2827), triglyceride (0.2526), HDL-cholesterol (-0.2800); stab leukocytes - number of cigarettes (0.2460); segmented leukocytes - glycohemoglobin A1c (0.1495), number of cigarettes (0.2716), HDL-cholesterol (-0.3254); lymphocytes - BMI (0.2639), number of cigarettes (0.1495), triglyceride (0.3520); monocytes - glycohemoglobin A1c (0.2617). These findings indicated that the risk factors of atherosclerosis may influence sICAM1 concentration and leukocyte count.
Noguchi
T
T
Japan Research Foundation for Chronic Diseases and Rehabilitation, Sakuragaoka Hospital, Nishinomiya, Hyogo.
Tsujisaki
M
M
Imai
K
K
Dodo
M
M
Tabuchi
Y
Y
Nakajima
T
T
Kajita
A
A
Hayashi
I
I
Sugiura
T
T
Kumahara
Y
Y
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood* / Q000209:etiology* / Q000276:immunology; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D012995:Solubility; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D018799:Intercellular Adhesion Molecule-1; D014280:Triglycerides