Second symmetry in the BALB/c-C57BL/6 (B6) system, and anti-antiself antibodies in ageing B6 mice.
Using an ELISA assay and inhibition of antibody mediated cytotoxicity we found that there was a higher level of anti-antiself activity in B6 anti-BALB/c alloimmune mice than in BALB/c anti-B6 mice. In contrast, when an inhibition of cellular cytotoxicity assay was used to assay for the activity, similar levels of anti-antiself antibodies were seen in B6 anti-BALB/c and BALB/c anti-B6 sera. Anti-antiself antibodies in alloimmune sera are not absorbed by the cellular immunogen as readily as are anti-foreign antibodies. These results are interpreted in terms of anti-antiself antibodies being directed mainly against T cell receptors specific for self. Anti-antiself antibodies are found also in old B6 mice, that are also known to make autoantibodies.
al-Fahim
A
A
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Hoffmann
G W
GW
D000042:Absorption; D000375:Aging / Q000276:immunology*; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001710:Biotin; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D005260:Female; D007126:Immunoglobulin Allotypes / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D008810:Mice, Inbred C57BL / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D011948:Receptors, Antigen, T-Cell; D001710:Biotin; D003165:Complement System Proteins