Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissue.
Recently, we demonstrated the presence of Interleukin-8 (IL-8) in human breast cancer (HBC) tissue. We hypothesize that the IL-8 receptors are present and play a role in tumor cell and vascular endothelial cell (VEC) activation (e.g. proliferation and angiogenesis).


METHODS
Immunohistochemical analysis for IL-8 receptors (IL-8RA and IL-8RB) was performed on 43 malignant and 8 benign breast tissue samples.


RESULTS
Tumor cells expressed IL-8RA and IL-8RB in all of the malignant specimens. Only 50% of the benign ductal epithelial cell (DEC) samples expressed these receptors. The majority of small vessel endothelial cells (SVEC) expressed IL-8RA and IL-8RB, while large vessel endothelial cells (LVEC) showed primarily IL-8RB expression.


CONCLUSIONS
Our results demonstrate that tumor and VEC express the IL-8 receptors and likely play a role in regulating tumor and VEC activation which controls proliferation, angiogenesis and metastasis in HBC.
Miller
L J
LJ
Department of Pathology, University of Connecticut, School of Medicine, Farmington 06030, USA.
Kurtzman
S H
SH
Wang
Y
Y
Anderson
K H
KH
Lindquist
R R
RR
Kreutzer
D L
DL
D015703:Antigens, CD / Q000378:metabolism*; D001941:Breast Diseases / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D009389:Neovascularization, Pathologic; D018123:Receptors, Interleukin / Q000378:metabolism*; D023062:Receptors, Interleukin-8A
D015703:Antigens, CD; D018123:Receptors, Interleukin; D023062:Receptors, Interleukin-8A