The loss of immunity in directly transmitted infections modeling: effects on the epidemiological parameters.
When directly transmitted infectious diseases are modeled assuming an everlasting induced immunity (and constant contact rate), there are well-established formulas to deal with, which is not true if we include the loss of induced immunity. In general, the immunity induced by the disease is everlasting. We propose a model considering the loss of immunity and present methods for the estimation of two epidemiological parameters: the force of infection and the basic reproduction ratio. We also analyze the effects of the loss of immunity on these parameters. Based on these results, we concluded that reinfection can play an important role in highly vaccinated populations.
Yang
H M
HM
Universidade Estadual de Campinas, IMECC-Departamento de Matemática Aplicada, SP, Brazil. hyunyang@ime.unicamp.br
Silveira
A S
AS
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007110:Immunity, Active; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000453:epidemiology* / Q000276:immunology* / Q000635:transmission; D008954:Models, Biological; D011157:Population Dynamics; D012008:Recurrence; D012409:Rubella / Q000453:epidemiology / Q000276:immunology; D014611:Vaccination