[Medical-scientific research in the elderly in The Netherlands; historic milestones and methodological problems].
OBJECTIVE
To describe the methodological development of medical research regarding elderly subjects in the Netherlands.


METHODS
Descriptive.


METHODS
Nijmegen University, the Netherlands.


METHODS
All research on aging published in the Netherlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine) starting from its first volume in 1857 up to 1983 was studied. Selected were those articles in which new research methods were introduced. Next, six pioneering researchers in geriatrics were interviewed on the methodological development of geriatric research and on the problems they encountered in their own research.


RESULTS
Research started with studies on age-associated diseases such as prostatism, presbyacusis and senile dementia. It was only after a considerable delay that new diagnostic instruments such as electrocardiography and new research designs such as randomized trials found their way into research on elderly patients. The development of a questionnaire on the health of the elderly, the introduction of the concept of activities of daily living and of diagnostic instruments in the field of psychogeriatrics were important steps that made possible current geriatric research. From the outset, researchers encountered methodological problems still relevant in current research and caused by characteristics of geriatric patients: frailty, high prevalence of comorbidity, coexistence of physical, psychological and social problems, and large interindividual differences.
Olde Rikkert
M G
MG
Academisch Ziekenhuis, afd. Klinische Geriatrie, Nijmegen.
van Heteren
G M
GM
Hoefnagels
W H
WH
D000203:Activities of Daily Living; D000368:Aged; D000375:Aging; D003704:Dementia / Q000503:physiopathology; D005260:Female; D005853:Geriatrics; D006304:Health Status; D006801:Humans; D008017:Life Expectancy; D008297:Male; D009426:Netherlands; D009735:Nursing Homes; D011304:Presbycusis / Q000503:physiopathology; D011470:Prostatic Hyperplasia / Q000503:physiopathology; D011581:Psychological Tests; D012107:Research Design