Antidepressant-associated mania: a study of anxiety disorders patients.
Antidepressants are related to the emergence of manic and hypomanic episodes in mood disorder patients. This study examined whether antidepressant-associated manic states are also present in anxiety disorder patients, so that this phenomenon may be defined as a side-effect. A total of 167 consecutive patients at a specialized outpatient clinic, suffering from anxiety disorders and treated by antidepressants, were assessed in a blind, retrospective chart review. Five patients (2.99%) were identified as having suffered an episode of antidepressant-associated mania within 3 months of initiation of treatment. All were females and all had an axis II diagnosis of a cluster B personality disorder. Antidepressant-associated mania appears to be related to risk factors such as personality disorder, even in non-mood disorder patients, tentatively suggesting that it is not simply an adverse event but rather a reflection of an underlying psychopathology.
Levy
D
D
The Y. Abarbanel Mental Health Center, Bat-Yam, (affiliated with the Sackler School of Medicine, Tel-Aviv University), Israel.
Kimhi
R
R
Barak
Y
Y
Aviv
A
A
Elizur
A
A
D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects*; D001008:Anxiety Disorders / Q000523:psychology*; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D000928:Antidepressive Agents