title: Comparison of EEG, MRI and PET in reading epilepsy: a case report.
abstract: The pathophysiological and neuroanatomical bases of reading epilepsy (RE) are unclear. We performed video-EEG, high quality MRI and [11C]diprenorphine PET in a patient with RE to detect structural and functional abnormalities. EEG showed multifocal seizure onset bilaterally in temporal and fronto-central regions. MRI was normal, whereas [11C]diprenorphine PET revealed peri-ictal opioid binding decreases in both temporal lobes and the left frontal lobe. These findings confirm that RE is due to abnormal activity in the network subserving reading.
authors.affiliation: Department of Neurology, Universitatsklinikum Rudolf Virchow, Berlin, Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Koepp
authors.forename: M L
authors.initials: ML
authors.lastname: Hansen
authors.forename: R M
authors.initials: RM
authors.lastname: Pressler
authors.forename: D J
authors.initials: DJ
authors.lastname: Brooks
authors.forename: U
authors.initials: U
authors.lastname: Brandl
authors.forename: B
authors.initials: B
authors.lastname: Guldin
authors.forename: J S
authors.initials: JS
authors.lastname: Duncan
authors.forename: S
authors.initials: S
authors.lastname: Ried
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D004174:Diprenorphine / Q000493:pharmacokinetics; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D011932:Reading; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D004174:Diprenorphine