Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice.
The ginsenosides Rb1 and Rg1, the major components of ginseng saponin, inhibited not only methamphetamine-induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Dopamine (DA) receptor supersensitivity, which developed in methamphetamine-induced CPP mice, was also inhibited by both Rb1 and Rg1. Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine-induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine-induced dysfunction at both the pre- and postsynaptic DA receptors.
Kim
H S
HS
College of Pharmacy, Chungbuk National University, Cheongju, South Korea.
Hong
Y T
YT
Oh
K W
KW
Seong
Y H
YH
Rheu
H M
HM
Cho
D H
DH
Oh
S
S
Park
W K
WK
Jang
C G
CG
D018663:Adrenergic Agents; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects*; D036145:Ginsenosides; D006948:Hyperkinesis / Q000139:chemically induced; D008297:Male; D008694:Methamphetamine; D051379:Mice; D008813:Mice, Inbred ICR; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D012503:Saponins / Q000494:pharmacology*
D018663:Adrenergic Agents; D002491:Central Nervous System Agents; D036145:Ginsenosides; D011954:Receptors, Dopamine; D012503:Saponins; D008694:Methamphetamine; C035054:ginsenoside Rg1