MRI-neuropathological correlations in type 1 lissencephaly.
Although imperfect, MRI is the best way of distinguishing type 1 lissencephaly from other, less classical lissencephalic malformations. We reported a case in which correlation of MRI and neuropathology was possible. Besides the classical radiological features of lissencephaly, i.e., agyria and excessive thickness of the cortex, an additional sign was observed: a thin cortical band, which gave high signal on T2-weighted images, represented a paucicellular and partially myelinated band, 1500 microns thick, lying under the true superficial cortex. This MRI feature could be characteristic of the particular cortical lamination observed in true type 1 lissencephaly.
Landrieu
P
P
Department of Paediatric Neurology, CHU Bicêtre, France.
Husson
B
B
Pariente
D
D
Lacroix
C
C
D002540:Cerebral Cortex / Q000002:abnormalities*; D000013:Congenital Abnormalities / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male