title: Asymmetry in the occlusal morphology of first permanent molars in 45,X/46,XX mosaics.
abstract: The genetic control of dental morphology is affected by various chromosomal aberrations, and morphological changes familiar to specific aneuploidies can be distinguished in many cases. Asymmetry between bilateral teeth in the dental arch in laboratory animals shows increased expression after exposure to external stress during development. Bilateral asymmetry in occlusal cuspal morphology has not been widely used as a means of odontometric examination, partly because accurate and reliable methods are not commonly available. The aim here was to examine linear and angular variables of the occlusal morphology of maxillary and mandibular first permanent molars in three dimensions in individuals with 45,X/46,XX mosaicism and to find out if this aneuploidism causes deviations from normal development and increased asymmetry in bilateral variables of the occlusal surface. The participants were five females with 45,X/46,XX chromosome constitution, whose karyotypes were confirmed by cytogenetic tests of skin fibroblasts. The controls were 10 first-degree female relatives of the mosaic patients with normal 46,XX chromosome constitution. The method of measuring the three-dimensional morphology of occlusal surfaces was based on a machine-vision technique using a single video-imaging camera. An apparent increase in asymmetry of occlusal morphology in first permanent molars in 45,X/46,XX mosaics was found. As there was evidence of directional asymmetry, it is possible that different cell lines regulated by discrete genes cause the directionality.
authors.affiliation: Institute of Dentistry, University of Oulu, Finland. ppirttin@cc.oulu.fi
authors.forename: P
authors.initials: P
authors.lastname: Pirttiniemi
authors.forename: L
authors.initials: L
authors.lastname: Alvesalo
authors.forename: O
authors.initials: O
authors.lastname: Silvén
authors.forename: J
authors.initials: J
authors.lastname: Heikkilä
authors.forename: J
authors.initials: J
authors.lastname: Julku
authors.forename: P
authors.initials: P
authors.lastname: Karjalahti
mesh_terms: D000782:Aneuploidy; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007621:Karyotyping; D008334:Mandible; D008437:Maxilla; D008963:Molar / Q000002:abnormalities* / Q000473:pathology; D009030:Mosaicism / Q000235:genetics*; D009805:Odontogenesis / Q000235:genetics; D009811:Odontometry; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D019228:Tooth Crown / Q000002:abnormalities / Q000473:pathology; D014741:Video Recording; D014960:X Chromosome / Q000235:genetics*