[Drug delivery system for diabetes].
Long-term intensified insulin therapy composing of multiple insulin injection and self-blood glucose monitoring enables glycemic control of insulin-requiring diabetics. For reducing inconvenience of this therapy, several delivery route of insulin are under investigation. Nasal administration of insulin aerosol effectively controlled insulin-dependent diabetics for up to 6 months because its high bioavailability and rapid absorption. By means of ionophoresis or ultrasound approach, insulin was shown to be absorbed transdermally. Polymer containing modified insulin and immobilized enzyme could increase insulin release against hyperglycemia. These new approach of insulin delivery might increase convenience of insulin administration.
Yamasaki
Y
Y
First Dept. of Med., Osaka University School of Med.
D000279:Administration, Cutaneous; D000281:Administration, Intranasal; D003692:Delayed-Action Preparations; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D016503:Drug Delivery Systems; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011108:Polymers; D014465:Ultrasonics
D003692:Delayed-Action Preparations; D007004:Hypoglycemic Agents; D007328:Insulin; D011108:Polymers