[Design and application of oral sustained-release anticancer drug--a new oral dosage form of cisplatin].
As compared to the conventional standard chemotherapy of solid cancer such as lung, biochemical modulation (BCM) therapy has been proven to have a good therapeutic efficiency. BCM therapy uses the low dose and low infusion rate of anti-cancer drug. To increase of the QOL of cancer patients, oral BCM therapy is needed. For this purpose, two kinds of new oral sustained-release cisplatin preparations were developed, micro-porous CDDP capsule made of ethylcellulose(EC) and CDDP-EC-stearic acid solid dispersion. After oral administrations of these preparations, serum CDDP levels were maintained over 0.2 microgram/ml for 24h. Experimental therapy using P815 tumor cells transplanted mice suggested the usefulness of CDDP solid dispersion preparation.
Nakagawa
T
T
Department of Pharmaceutics and Pharmacokinetics, Kyoto Pharmaceutical University.
Kawamura
T
T
Matsumura
Y
Y
Yoshikawa
Y
Y
Takada
K
K
Ike
O
O
Wada
H
H
Hitomi
S
S
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013229:Stearic Acids
D000970:Antineoplastic Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D013229:Stearic Acids; C031183:stearic acid; C013517:ethyl cellulose; D002482:Cellulose; D002945:Cisplatin