title: Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction.
abstract: A prospective study was conducted on 34 stable septic patients to determine whether mild hyperlactatemia is a marker of lactate overproduction or an indicator of lactate underutilization during sepsis. Plasma lactate clearance and lactate production were evaluated by modeling the lactate kinetic induced by an infusion of 1 mmol/kg L-lactate over 15 min. The patients were divided in two groups depending on their blood lactate: < or = 1.5 mmol/L (n = 20, lactate = 1.2+/-0.2 mmol/L) or > or = 2 mmol/L (n = 10, lactate = 2.6+/-0.6 mmol/L). The hyperlactatemic patients had a lower lactate clearance (473+/-102 ml/kg/h) than those with normal blood lactate (1,002+/-284 ml/kg/h, p < 0.001), whereas lactate production in the two groups was similar (1,194+/-230 and 1,181+/-325 micromol/kg/h, p = 0.90). A second analysis including all the patients confirmed that the blood lactate concentration was closely linked to the reciprocal of lactate clearance (r2 = 0.73, p < 0.001) but not to lactate production (r2 = 0.03, p = 0.29). We conclude that a mild hyperlactatemia occurring in a stable septic patient is mainly due to a defect in lactate utilization.
authors.affiliation: Département d'Anesthésie-Réanimation, Centre Hospitalier Universitaire de Nice, France.
authors.forename: J
authors.initials: J
authors.lastname: Levraut
authors.forename: J P
authors.initials: JP
authors.lastname: Ciebiera
authors.forename: S
authors.initials: S
authors.lastname: Chave
authors.forename: O
authors.initials: O
authors.lastname: Rabary
authors.forename: P
authors.initials: P
authors.lastname: Jambou
authors.forename: M
authors.initials: M
authors.lastname: Carles
authors.forename: D
authors.initials: D
authors.lastname: Grimaud
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011446:Prospective Studies; D018805:Sepsis / Q000378:metabolism*
chemical_list: D019344:Lactic Acid