title: One-step synthesis and pharmacological activity of new (N-substituted)amino-spiroalkan-dione derivatives.
abstract: The synthesis of (N-substituted)amino-spiroalkan-dione derivatives 3 is described starting from enamines 1 and carbon suboxide 2, and their inhibitory effects on blood coagulation in vivo and on platelet aggregation in vitro are determined. Some of synthesized compounds showed a strong anticoagulant activity. A comparative pharmacological study of the anticoagulant effects of the new compounds versus Warfarin suggests that their behaviour is analogous, though the action mechanism is different.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università di Cagliari, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Bonsignore
authors.forename: G
authors.initials: G
authors.lastname: Loy
authors.forename: F
authors.initials: F
authors.lastname: Cottiglia
authors.forename: A
authors.initials: A
authors.lastname: Calignano
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D003094:Collagen / Q000494:pharmacology; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010972:Platelet Activating Factor / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards; D013057:Spectrum Analysis; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D003503:Cyclobutanes; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D013141:Spiro Compounds; D000244:Adenosine Diphosphate; D003094:Collagen