[18F]fluoride PET indicates reduced bone formation in severe glucocorticoid-induced osteoporosis.
A 61-year-old female patient presenting with mixed connective tissue disease (Sharp syndrome), underwent a long-term high dose glucocorticoid treatment because of multiple organ manifestations. Under steroid therapy she developed severe osteoporosis resulting in multiple fractures. A dynamic [18F]fluoride PET study in this patient revealed reduced fluoride influx in non-fractured vertebrae. This finding corresponds to pathogenetic concepts which propose an inhibition of bone formation as major cause of glucocorticoid-induced osteoporosis. In the light of the presented case it seems to be promising to evaluate the diagnostic benefit of [18F]fluoride PET in osteoporosis.
Berding
G
G
Klinik für Nuklearmedizin, Medizinischen Hochschule Hannover, Germany. berding.georg@mh-hannover.de
Kirchhoff
T D
TD
Burchert
W
W
von der Hoff
J
J
Zeidler
H
H
Hundeshagen
H
H
Knapp
W H
WH
D004947:Esophagus / Q000000981:diagnostic imaging; D005260:Female; D005459:Fluorides; D005462:Fluorine Radioisotopes; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000209:etiology; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000009:adverse effects*; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D010024:Osteoporosis / Q000139:chemically induced / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D012129:Respiratory Function Tests; D013669:Technetium Tc 99m Medronate; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
D005462:Fluorine Radioisotopes; D005938:Glucocorticoids; D019275:Radiopharmaceuticals; D005459:Fluorides; D008775:Methylprednisolone; D013669:Technetium Tc 99m Medronate