[Influence of mycobacterium on adaptive rearrangement in guinea pigs long exposed to polycystic aromatic hydrocarbon-containing agents].
Experiments on different groups of guinea pigs inoculated with Mycobacterium tuberculosis (MBT) and intact guinea pigs who received coal refining products and control ones indicated that long exposure to coal-tar resin enhanced mobilization of methionine from the liver with its accumulation in the lung and hematopoietic organs, increased the biosynthesis of arginine in the liver and its accumulation in the lung and hematopoietic organs. MBT drastically enhanced the exchange of the metabolites accumulated in the organs and prevented the formation of adaptive reactions to long-term exposure to polycyclic aromatic hydrocarbons at the level of membranous metabolism.
Pavlov
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D000220:Adaptation, Biological / Q000187:drug effects*; D000818:Animals; D001120:Arginine / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008715:Methionine / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000472:pathogenicity; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D014376:Tuberculosis / Q000378:metabolism* / Q000382:microbiology
D011084:Polycyclic Aromatic Hydrocarbons; D001120:Arginine; D008715:Methionine