Mechanisms of chromosome segregation in metazoan cells.
Despite over 100 year of research, the mechanisms that cells use to ensure the proper segregation of chromosomes during mitosis are still surprisingly obscure. However, recent high resolution video light microscopic studies of dividing cells are telling us new and important information about chromosome behavior. Molecular genetics is enabling us to build a more complete list of the components involved in chromosome segregation. And in vitro assays for chromosome segregation are providing information about the signals that control the equipartitioning of sister chromatids during cell division.
Wordeman
L
L
Department of Physiology and Biophysics, University of Washington Medical School, Seattle 98195, USA.
D000818:Animals; D001324:Autoantigens; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D002875:Chromosomes / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D008938:Mitosis
D001324:Autoantigens; D000076247:Centromere Protein A; D002868:Chromosomal Proteins, Non-Histone