title: Effect of creatine supplementation on sprint exercise performance and muscle metabolism.
abstract: The aim of the present study was to examine the effect of creatine supplementation (CrS) on sprint exercise performance and skeletal muscle anaerobic metabolism during and after sprint exercise. Eight active, untrained men performed a 20-s maximal sprint on an air-braked cycle ergometer after 5 days of CrS [30 g creatine (Cr) + 30 g dextrose per day] or placebo (30 g dextrose per day). The trials were separated by 4 wk, and a double-blind crossover design was used. Muscle and blood samples were obtained at rest, immediately after exercise, and after 2 min of passive recovery. CrS increased the muscle total Cr content (9.5 +/- 2.0%, P < 0.05, mean +/- SE); however, 20-s sprint performance was not improved by CrS. Similarly, the magnitude of the degradation or accumulation of muscle (e.g., adenine nucleotides, phosphocreatine, inosine 5'-monophosphate, lactate, and glycogen) and plasma metabolites (e.g. , lactate, hypoxanthine, and ammonia/ammonium) were also unaffected by CrS during exercise or recovery. These data demonstrated that CrS increased muscle total Cr content, but the increase did not induce an improved sprint exercise performance or alterations in anaerobic muscle metabolism.
authors.affiliation: Department of Biomedical Sciences, Centre for Rehabilitation, Exercise, and Sport Science, and Victoria University of Technology, Melbourne 8001, Australia.
authors.forename: R J
authors.initials: RJ
authors.lastname: Snow
authors.forename: M J
authors.initials: MJ
authors.lastname: McKenna
authors.forename: S E
authors.initials: SE
authors.lastname: Selig
authors.forename: J
authors.initials: J
authors.lastname: Kemp
authors.forename: C G
authors.initials: CG
authors.lastname: Stathis
authors.forename: S
authors.initials: S
authors.lastname: Zhao
mesh_terms: D000227:Adenine Nucleotides / Q000032:analysis; D000284:Administration, Oral; D000328:Adult; D000641:Ammonia / Q000097:blood; D003401:Creatine / Q000097:blood / Q000494:pharmacology*; D019587:Dietary Supplements; D006801:Humans; D019271:Hypoxanthine / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D010725:Phosphocreatine / Q000032:analysis; D005082:Physical Exertion / Q000502:physiology*
chemical_list: D000227:Adenine Nucleotides; D010725:Phosphocreatine; D019271:Hypoxanthine; D019344:Lactic Acid; D000641:Ammonia; D003401:Creatine