Expression of Ly-6C on microglia in the developing and adult mouse brain.
Expression of Ly-6C, a murine homolog of human CD59, in the brain was examined immunologically using an ER-MP20 monoclonal antibody both in vitro and in vivo. Ly-6C was expressed both on the isolated microglia and on microglia in the developing and adult cerebellum. The number of cerebellar microglia expressing Ly-6C markedly increased during the first postnatal week in mouse development. The expression of Ly-6C on microglia in the developing and adult brain may be related to the unique role(s) of microglia under normal and/or pathological conditions of the brain.
Tanaka
M
M
Division of Cell Biology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan. mtanaka@fujita-hu.ac.jp
Marunouchi
T
T
Sawada
M
M
D000818:Animals; D000831:Animals, Newborn; D018957:CD59 Antigens / Q000032:analysis*; D002478:Cells, Cultured; D002531:Cerebellum / Q000254:growth & development / Q000378:metabolism*; D006023:Glycoproteins / Q000032:analysis*; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
D018957:CD59 Antigens; D006023:Glycoproteins