title: Ankylosing spondylitis and infections of the female urogenital tract.
abstract: Thirty-two female patients with confirmed ankylosing spondylitis (AS) and 33 women of similar age with pure ileitis terminalis Crohn were examined for genitourinary infection. Urethral syndrome was found in 15 out of 32 patients with AS: 11 of them had urethritis and 4 urethritis associated with vaginitis. Five women of the control group suffered from urethritis. In all cases with genitourinary infection, Chlamydia trachomatis was isolated. By comparing the AS-patients (urogenital infection group and the non-infected group) with regard to other present clinical parameters, it was found, as expected, that the erythrocyte sedimentation rate in the 1st hour was significantly higher in the infected group. In addition, the infected patients had a significantly higher incidence of enthesopathy, involvement of the spinal column, and higher C-reactive protein values (CRP > or = 5 mg/l). A family history of AS was equally present. Other clinical parameters, such as inflammatory involvement of the joints and HLA-B27 correlation, did not differ significantly between infected and non-infected patients.
authors.affiliation: Department of Rheumatology/University Giessen, Bad Nauheim, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Lange
authors.forename: M
authors.initials: M
authors.lastname: Berliner
authors.forename: M
authors.initials: M
authors.lastname: Ludwig
authors.forename: H G
authors.initials: HG
authors.lastname: Schiefer
authors.forename: J
authors.initials: J
authors.lastname: Teichmann
authors.forename: W
authors.initials: W
authors.lastname: Weidner
authors.forename: K L
authors.initials: KL
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D002690:Chlamydia Infections / Q000150:complications / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D005260:Female; D052776:Female Urogenital Diseases / Q000150:complications / Q000382:microbiology*; D005831:Genital Diseases, Female / Q000150:complications / Q000276:immunology; D015796:HLA-B27 Antigen / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000382:microbiology; D014521:Urethra / Q000382:microbiology; D014552:Urinary Tract Infections / Q000150:complications / Q000276:immunology; D014621:Vagina / Q000382:microbiology
chemical_list: D015796:HLA-B27 Antigen