[Arthritis caused by use of rifabutine++ in Mycobacterium avium infection].
A 60-year-old HIV-seronegative man with a Mycobacterium avium pulmonary infection was treated with rifabutin, ethambutol and clarithromycin. He developed a serious arthritis which disappeared after interruption of the medication and recurred after resumption. The arthritis was attributed to the use of rifabutin. This adverse effect is more frequent with higher doses and in combination with the use of macrolide antibiotics.
van Denderen
J C
JC
Jan van Breemen Instituut, Amsterdam.
Mensen
E A
EA
Vints
A M
AM
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001168:Arthritis / Q000139:chemically induced*; D018023:HIV Seronegativity; D006801:Humans; D008297:Male; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy*; D017828:Rifabutin / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D017828:Rifabutin