title: Membranoproliferative glomerulonephritis in the aged and its possible causal relationship with CD8+CD57+ lymphocytes.
abstract: Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive glomerulonephritis that occurs primarily in patients under the age of 30, and is rare in the elderly. We report eight aged patients with MPGN associated with CD8+CD57+ lymphocytosis. All eight patients showed a significant increase in CD8+CD57+ lymphocytes with a significant decrease in the ratio of CD4+ cells to CD8+ cells. Infiltration of CD8+CD57+ lymphocytes was observed within capillary lumens to various degrees according to the severity of endocapillary proliferation in each case. Expression of endothelial-leukocyte adhesion molecule-1 was observed in a focal and segmental manner on glomerular endothelial cells and on the endothelium of arterioles and arteries in kidney tissue in four cases in which a pronounced endocapillary proliferation was simultaneously seen. These findings suggest that cell-mediated cytotoxic mechanisms against glomerular endothelial cells may be involved in the pathogenesis of MPGN in the aged.
authors.affiliation: Department of Nephrology, Sendai Shakaihoken Hospital, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Hotta
authors.forename: N
authors.initials: N
authors.lastname: Yusa
authors.forename: T
authors.initials: T
authors.lastname: Furuta
authors.forename: S
authors.initials: S
authors.lastname: Onodera
authors.forename: H
authors.initials: H
authors.lastname: Kitamura
authors.forename: Y
authors.initials: Y
authors.lastname: Taguma
mesh_terms: D000367:Age Factors; D000368:Aged; D018959:CD57 Antigens / Q000032:analysis*; D018414:CD8-Positive T-Lymphocytes; D019040:E-Selectin / Q000032:analysis; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007150:Immunohistochemistry; D007668:Kidney / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged
chemical_list: D018959:CD57 Antigens; D019040:E-Selectin; D007074:Immunoglobulin G