title: In vivo cardiotonic activity of aryl- and pyridyl-substituted fused imidazoles.
abstract: Two new imidazo[2,1-b]thiazoles related to sulmazole were synthesized and subjected to an in vivo cardiotonic assay with 14 analog compounds which gave the best results in previously reported in vitro tests. The data obtained show that three substituents (3-pyridyl, 4-pyridyl and 2,5-dimethoxyphenyl group) are useful pharmacophoric groups in modulating the in vivo cardiotonic activity of the fused imidazoles considered.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Andreani
authors.forename: A
authors.initials: A
authors.lastname: Leoni
authors.forename: R
authors.initials: R
authors.lastname: Morigi
authors.forename: R
authors.initials: R
authors.lastname: Bossa
authors.forename: M
authors.initials: M
authors.lastname: Chiericozzi
authors.forename: I
authors.initials: I
authors.lastname: Galatulas
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D007093:Imidazoles