title: Topical aspirin provides protection against galactosemic cataract.
abstract: Effect of twice daily administration of aspirin eyedrops on the onset and progression of cataract induced by 30% galactose diet was studied. On the 30th day of galactose feeding while all control group rats showed complete stage IV opacity, those receiving aspirin eyedrops showed only mild cataractous changes of stage I. In vitro studies showed that addition of aspirin to the medium significantly decreased dulcitol formation (p < 0.01) and maintained glutathione levels (p < 0.02). Intraocular penetration studies using isolated goat cornea showed excellent penetration by salicylate indicating feasibility of topical administration. The results of the present study demonstrate that topical aspirin possesses significant anticataract activity in galactosemic cataract.
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: Joshi
authors.forename: R
authors.initials: R
authors.lastname: Tandon
authors.forename: P
authors.initials: P
authors.lastname: Mathur
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001241:Aspirin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002386:Cataract / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D004032:Diet; D004376:Galactitol / Q000037:antagonists & inhibitors / Q000378:metabolism; D005693:Galactosemias / Q000097:blood / Q000150:complications*; D005978:Glutathione / Q000378:metabolism; D007908:Lens, Crystalline / Q000187:drug effects* / Q000378:metabolism; D009883:Ophthalmic Solutions; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D004376:Galactitol; D005978:Glutathione; D001241:Aspirin