title: Antigenic homology of HIV-1 GP41 and human platelet glycoprotein GPIIIa (integrin beta3).
abstract: Fifty-eight of 89 serum samples (65.17%) from HIV-1-infected individuals at various disease stages contain antibodies that react with a platelet peptide located in the cytoplasmic domain of integrin beta3, glycoprotein GPIIIa (aa749-761; sequence DRKEFAKFEEERA). Rabbit polyclonal antibodies raised against the synthetic platelet peptide also react with the structurally homologous HIV-1 gp41-derived peptide (EKNEQELLELDKW(A)) and bind to a Western blot band with molecular weight corresponding to HIV-1 gp41. These findings point to molecular mimicry between HIV-1 and a human membrane protein found in platelets and other cells that could be of pathologic consequence.
authors.affiliation: Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, DF, Mexico.
authors.forename: V
authors.initials: V
authors.lastname: Dominguez
authors.forename: G
authors.initials: G
authors.lastname: Gevorkian
authors.forename: T
authors.initials: T
authors.lastname: Govezensky
authors.forename: H
authors.initials: H
authors.lastname: Rodriguez
authors.forename: M
authors.initials: M
authors.lastname: Viveros
authors.forename: G
authors.initials: G
authors.lastname: Cocho
authors.forename: Y
authors.initials: Y
authors.lastname: Macotela
authors.forename: F
authors.initials: F
authors.lastname: Masso
authors.forename: M
authors.initials: M
authors.lastname: Pacheco
authors.forename: J L
authors.initials: JL
authors.lastname: Estrada
authors.forename: C
authors.initials: C
authors.lastname: Lavalle
authors.forename: C
authors.initials: C
authors.lastname: Larralde
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D000947:Antigens, Helminth / Q000737:chemistry / Q000276:immunology; D015153:Blotting, Western; D003551:Cysticercosis / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology; D015700:HIV Envelope Protein gp41 / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D015658:HIV Infections / Q000097:blood / Q000276:immunology; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1 / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D015801:Helminth Proteins / Q000276:immunology; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D039661:Integrin beta3; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000276:immunology; D010455:Peptides / Q000737:chemistry / Q000276:immunology; D010976:Platelet Count; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D011817:Rabbits; D017386:Sequence Homology, Amino Acid; D012698:Serologic Tests
chemical_list: D000909:Antibodies, Helminth; D015703:Antigens, CD; D000947:Antigens, Helminth; D000939:Epitopes; D015483:HIV Antibodies; D015700:HIV Envelope Protein gp41; D015801:Helminth Proteins; D007106:Immune Sera; D039661:Integrin beta3; D009842:Oligopeptides; D010455:Peptides; D010980:Platelet Membrane Glycoproteins