title: Outcome of 67 patients with hepatocellular cancer detected during screening of 1125 patients with chronic hepatitis.
abstract: OBJECTIVE
  We performed this prospective screening trial in chronic hepatitis virus-infected patients to determine the incidence of hepatocellular cancer (HCC) and the resectability and long-term survival rates of these HCC patients.
  
  
  BACKGROUND
  Chronic hepatitis B or C virus infection is a major etiologic factor in human HCC. It is not clear if routine screening of chronic viral hepatitis patients improves the survival of patients who develop HCC.
  
  
  METHODS
  Screening for HCC was offered to patients chronically seropositive (>5 years) for hepatitis B or C infection. All patients underwent percutaneous core liver biopsy to assess the histologic severity of chronic liver injury. Patients were screened initially and every 3 months thereafter with serum alpha-fetoprotein and transabdominal ultrasound evaluations; HCC was confirmed by needle biopsy of liver tumors.
  
  
  RESULTS
  Screening was performed on 1125 hepatitis-positive patients (804 with hepatitis C, 290 with hepatitis B, 31 with both). On liver biopsy, 800 patients had mild chronic active hepatitis and 325 had severe chronic active hepatitis, cirrhosis, or both. Initial screening detected HCC in 61 patients. HCC was detected in six more patients during follow-up; thus, the incidence of HCC was 5.9% (67/1125). However, 66 of the 67 HCC cases (98.5%) arose in the 325 patients with severe chronic active hepatitis or cirrhosis (66/325 [20.3%] vs. 1/800 [0.1%], p < 0.0001 [Wilcoxon signed rank]). Median follow-up of the 67 HCC patients was 24 months. Locally advanced or metastatic, unresectable HCC occurred in 43 patients (64.2%); 24 patients (35.8%), including the 6 patients detected during follow-up screening, underwent margin-negative resection. The median survival for the 24 resected patients was 26 months, compared to 6 months for the 43 patients with unresectable cancer (p < 0.0001, Wilcoxon signed rank).
  
  
  CONCLUSIONS
  HCC was found to arise in 20.3% of patients with chronic hepatitis B or C infection and severe liver injury. Initial screening detected resectable lesions in less than half the HCC patients. Routine screening of chronic hepatitis B or C virus-infected patients with ultrasound and alpha-fetoprotein determination should be reserved for patients with severe chronic active hepatitis, cirrhosis, or both.
authors.affiliation: Department of Surgical Oncology at the G. Pascale National Cancer Institute, Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Izzo
authors.forename: F
authors.initials: F
authors.lastname: Cremona
authors.forename: F
authors.initials: F
authors.lastname: Ruffolo
authors.forename: R
authors.initials: R
authors.lastname: Palaia
authors.forename: V
authors.initials: V
authors.lastname: Parisi
authors.forename: S A
authors.initials: SA
authors.lastname: Curley
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control* / Q000601:surgery; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008113:Liver Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000517:prevention & control* / Q000601:surgery; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins