title: Fulminant hepatic failure associated with dicoumarol therapy.
abstract: Coumarins have been associated with non-predictable hepatic injury. In the case of dicoumarol, there is no hard evidence in the literature of a causal connection with liver damage. We report the case of a 73-year-old woman who developed a fatal liver disease of a mixed hepatocellular-cholestatic type after 3 months of treatment with dicoumarol. A thorough diagnostic work-up did not reveal any other possible cause of the liver disease.
authors.affiliation: Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Castedal
authors.forename: F
authors.initials: F
authors.lastname: Aldenborg
authors.forename: R
authors.initials: R
authors.lastname: Olsson
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D001728:Dicumarol / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008111:Liver Function Tests; D009336:Necrosis
chemical_list: D000925:Anticoagulants; D001728:Dicumarol