title: Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters.
abstract: Male golden Syrian hamsters were fed for 16 weeks on a hypercholesterolemic diet containing, per kg, 150 g of lipids (90 g butterfat, 35 g vitamin E-stripped corn oil and 25 g fish oil), 2 g cholesterol and either 3 IU vitamin E (3 IU E), 3 IU vitamin E and 200 mg catechin hydrate (3 IU E-200 Cat) or 30 IU vitamin E (30 IU E). More fatty streaks, measured by Oil Red O staining, were deposited in aortas of hamsters fed 3 IU E than in those fed either 3 IU E-200 Cat or 30 IU E. Lipid staining increased with plasma low-density lipoprotein cholesterol (LDL-C) in all animals. At the same concentration of LDL-C, animals fed either 3 IU E-200 Cat or 30 IU E developed less fatty streaks than those fed 3 IU E. Plasma LDL-C and total cholesterol were highest in hamsters fed 3 IU E and LDL-C and total cholesterol in animals fed 3 IU-200 Cat were not different from those fed either 3 IU E or 30 IU E. This study showed the importance of circulating plasma LDL-C on atherogenesis and the inhibitory effect on this process of both dietary vitamin E and catechin.
authors.affiliation: Department of Food Science and Technology, University of California, Davis 95616, USA.
authors.forename: R
authors.initials: R
authors.lastname: Xu
authors.forename: W H
authors.initials: WH
authors.lastname: Yokoyama
authors.forename: D
authors.initials: D
authors.lastname: Irving
authors.forename: D
authors.initials: D
authors.lastname: Rein
authors.forename: R L
authors.initials: RL
authors.lastname: Walzem
authors.forename: J B
authors.initials: JB
authors.lastname: German
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D002392:Catechin / Q000008:administration & dosage / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D006224:Cricetinae; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004042:Dietary Fats, Unsaturated; D000069463:Olive Oil; D010938:Plant Oils; D014810:Vitamin E; D002392:Catechin; D002784:Cholesterol