New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity: taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities.
Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activity when tested against a panel of other microorganisms.
Dekker
K A
KA
Central Research Division, Pfizer Pharmaceuticals Inc., Aichi, Japan.
Inagaki
T
T
Gootz
T D
TD
Huang
L H
LH
Kojima
Y
Y
Kohlbrenner
W E
WE
Matsunaga
Y
Y
McGuirk
P R
PR
Nomura
E
E
Sakakibara
T
T
Sakemi
S
S
Suzuki
Y
Y
Yamauchi
Y
Y
Kojima
N
N
D042462:4-Quinolones; D000191:Actinomycetaceae; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D042462:4-Quinolones; D000890:Anti-Infective Agents