title: Hypertrophic cardiomyopathy: role of the implantable cardioverter-defibrillator.
abstract: OBJECTIVE
  We report the occurrence of cardiac events during long-term follow-up in patients with hypertrophic cardiomyopathy (HCM) after cardioverter-defibrillator implantation.
  
  
  BACKGROUND
  The identification of patients at high risk for sudden death and the prevention of recurrence of sudden death in HCM represents a difficult problem.
  
  
  METHODS
  We retrospectively analyzed the occurrence of cardiac events during follow-up of 13 patients with HCM who received an implantable cardioverter-defibrillator (ICD) because of aborted sudden death (n = 10) or sustained ventricular tachycardia (n = 3) (group I). Findings were compared with those in 215 patients with an ICD and other structural heart disease or idiopathic ventricular fibrillation (group II).
  
  
  RESULTS
  After a mean (+/-SD) follow-up period of 26+/-18 months, 2 of 13 patients in group I received appropriate shocks. The calculated cumulative incidence of shocks was 21% in group I and 66% in group II after 40 months (p < 0.05). We observed a low incidence of recurrence of ventricular tachycardia/fibrillation during follow-up in patients with HCM. No deaths occurred.
  
  
  CONCLUSIONS
  Our data suggest that ventricular tachyarrhythmias may not always be the primary mechanism of syncope and sudden death in patients with HCM. The ICD seems to have a less important impact on prognosis in patients with HCM than in patients with other etiologies of aborted sudden death.
authors.affiliation: Cardiovascular Center, Onze Lieve Vrouw Hospital, Aalst, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Primo
authors.forename: P
authors.initials: P
authors.lastname: Geelen
authors.forename: J
authors.initials: J
authors.lastname: Brugada
authors.forename: A L
authors.initials: AL
authors.lastname: Filho
authors.forename: L
authors.initials: L
authors.lastname: Mont
authors.forename: F
authors.initials: F
authors.lastname: Wellens
authors.forename: M
authors.initials: M
authors.lastname: Valentino
authors.forename: P
authors.initials: P
authors.lastname: Brugada
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000628:therapy*; D016757:Death, Sudden, Cardiac; D017147:Defibrillators, Implantable; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D014693:Ventricular Fibrillation / Q000150:complications / Q000628:therapy