title: Effects of transport and indomethacin on telemetered body temperature and release of cortisol and prolactin in pre-pubertal pigs.
abstract: Previous research indicates that acute physical stress (restraint) raises core temperature in growing pigs via a prostaglandin-dependent mechanism. This study investigated whether transport stress affects body temperature in pigs and whether any such changes might involve endogenous prostaglandins. Pre-pubertal boars (n = 7) were implanted with venous catheters and biotelemetry devices for the measurement of core temperature. They were transported for two hours, with and without indomethacin (IND) pre-treatment, and blood samples were taken at 15 minute intervals for the determination of plasma cortisol and prolactin concentrations. The results indicated that, contrary to predictions, body temperature tended to fall during transport and that the effect was exaggerated by IND. By contrast, cortisol concentrations increased during transport and were unaffected by IND whereas the tendency for transport to stimulate prolactin release was reversed by IND.
authors.affiliation: MAFF Welfare and Behaviour Laboratory, Babraham Institute, Cambridge.
authors.forename: R F
authors.initials: RF
authors.lastname: Parrott
authors.forename: R H
authors.initials: RH
authors.lastname: Bradshaw
authors.forename: D M
authors.initials: DM
authors.lastname: Lloyd
authors.forename: J A
authors.initials: JA
authors.lastname: Goode
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D012741:Sexual Maturation; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*; D013552:Swine; D013686:Telemetry / Q000379:methods / Q000662:veterinary; D013997:Time Factors; D014186:Transportation
chemical_list: D011388:Prolactin; D006854:Hydrocortisone; D007213:Indomethacin