[The prognostic criteria of the course in newly detected duodenal peptic ulcer].
OBJECTIVE
Elucidation of the significance of various factors in prognosis of duodenal ulcer (DU) severity.


METHODS
The observational study entered 18 new cases of DU and 13 healthy controls. All the patients were followed up for 7 years with annual esophagogastroduodenoscopy.


RESULTS
10 patients (group 1) had annual exacerbations of DU, 8 patients had rare exacerbations (group 2). Group 1 was characterized by basal acid hyperproduction, hyperpepsinogenemia, hypergastrinemia, marked contamination with Helicobacter pylori. Patients of group 2 had normal basal and pentagastrin-stimulated acid production, normopepsinogenemia, normogastrinemia, mild Helicobacter pylori infection.


CONCLUSIONS
The 7-year follow-up of new DU cases allowed demonstration of functional-morphological prognostic criteria for frequently and rarely recurrent DU courses.
Minushkin
O N
ON
Zverkov
I V
IV
D001706:Biopsy; D004381:Duodenal Ulcer / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D004386:Duodenum / Q000473:pathology; D016145:Endoscopy, Digestive System; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood; D016481:Helicobacter Infections / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D010435:Pepsinogens / Q000097:blood; D011379:Prognosis; D013270:Stomach / Q000473:pathology
D005755:Gastrins; D010435:Pepsinogens