title: Hepatocellular carcinoma presenting with paraneoplastic neurologic syndrome in a hepatitis B surface antigen-positive patient.
abstract: We report a hepatitis B surface antigen-positive patient who presented with paraneoplastic peripheral sensorimotor polyneuropathy and cranial nerve involvement, 6 months before a diagnosis of hepatocellular carcinoma was made. This makes us think that neurologic manifestations in hepatitis B surface antigen-positive patients warrant investigation to exclude an underlying hepatocellular carcinoma.
authors.affiliation: Department of Pathophysiology, Medical School, National University of Athens, Greece.
authors.forename: G S
authors.initials: GS
authors.lastname: Hatzis
authors.forename: I
authors.initials: I
authors.lastname: Delladetsima
authors.forename: C
authors.initials: C
authors.lastname: Koufos
mesh_terms: D000368:Aged; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D004279:DNA, Viral / Q000032:analysis; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis; D008297:Male; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000175:diagnosis; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D011597:Psychomotor Performance; D014057:Tomography, X-Ray Computed
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens