Developmental signalling: a careful balancing act.
Embryos of arthropods and chordates are patterned along the dorso-ventral axis by a gradient of secreted morphogens of the Bmp4/Dpp family. This gradient now appears to be shaped by the opposing activities of Bmp-sequestering proteins, on the one hand, and Bmp-releasing metalloproteases, on the other.
Lemaire
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P
LGPD, Institut de Biologie du Développement de Marseille, CNRS/INSERM/Université de la Méditerranée/AP de Marseille, Campus de Luminy, Case 907, F-13288, Marseille, France. lemaire@lgpd.univ-mrs.fr
Yasuo
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H
D000818:Animals; D001181:Arthropods / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D019521:Body Patterning; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism; D002816:Chordata, Nonvertebrate / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction
D019485:Bone Morphogenetic Proteins