Suppression of growth of Bomirski Ab melanoma and its metastasis in hamsters by angiogenesis inhibitor TNP-470.
The growth of solid tumors and their metastasis is dependent on the development of new blood vessels (angiogenesis). In this study, we examined the effect of the angiogenesis inhibitor TNP-470 on a fast growing melanoma in hamsters. The effect was observed both on tumor growth and metastasis. Treatment with TNP-470 caused a significant decrease in the rate of tumor growth and suppression of the development of metastasis in 63% of treated animals. Some of the hamsters treated with TNP-470 had the tumor excised and the effect of that operation on the development of metastasis was examined. In such cases the inhibitory effect of TNP-470 was weaker than in tumor bearing animals. This indicates that excision of tumor created more favourable conditions for angiogenesis and that the dose of TNP-470 should be increased to be effective in such conditions.
Myśliwski
A
A
Department of Histology and Immunology, Medical University of Gdańsk, Poland. anmys@amed01.amg.gda.pl
Szmit
E
E
Szatkowski
D
D
Sosnowska
D
D
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D006224:Cricetinae; D003510:Cyclohexanes; D005260:Female; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D008647:Mesocricetus; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D012717:Sesquiterpenes / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D003510:Cyclohexanes; D012717:Sesquiterpenes; D000077609:O-(Chloroacetylcarbamoyl)fumagillol