Transformation of some pyrido[2,3-d]pyrimidine derivatives into other di- and triheterocyclic systems.
It was stated that three analogous ethyl 2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylates (7-9) react with hydrazine hydrate giving derivatives of the new heterocyclic system pyrido[2,3,4-ef]pyridazino[3,4-e]-1,2,4-triazepine (10-12), pyrido[3,4-d]pyridazine (16-18) and pentaazaphenalene (13-15). The latters were formed in low yields. The results of the preliminary pharmacological study of 2 of these compounds are reported.
Sladowska
H
H
Department of Chemistry of Drugs, Wrocław University of Medicine, Poland.
Bodetko
M
M
Sieklucka-Dziuba
M
M
Rajtar
G
G
Zółkowska
D
D
Kleinrok
Z
Z
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared
D000700:Analgesics; D011743:Pyrimidines