title: [A case of Sairei-to-induced pneumonitis diagnosed by lymphocyte stimulation test of bronchoalveolar lavage fluid].
abstract: A 51-year-old woman was admitted with fever, cough and dyspnea. She had been taking Sairei-to, a traditional Chinese medicine, for 2 months. On admission, chest X-ray revealed a ground-glass appearance in the lung fields bilaterally and serum LDH was elevated. A differential cell count of the bronchoalveolar lavage fluid (BALF) showed that lymphocytes were increased, with a decreased ratio of CD4/CD8 cells. A lymphocyte stimulation test (LST) for Sairei-to using the lymphocytes in BALF was a positive, although a test of peripheral blood was negative. Sairei-to-induced pneumonitis was diagnosed based on the clinical course, laboratory findings, BALF cell analysis and LST of BALF. Only 4 cases of pneumonitis due to Sairei-to have been reported. This case suggests that LST of BALF is useful for diagnosing drug-induced pneumonitis.
authors.affiliation: Department of Internal Medicine, Tano General Hospital, Fujioka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Maeno
authors.forename: M
authors.initials: M
authors.lastname: Ubukata
authors.forename: Y
authors.initials: Y
authors.lastname: Maeno
authors.forename: T
authors.initials: T
authors.lastname: Suga
authors.forename: M
authors.initials: M
authors.lastname: Motegi
authors.forename: N
authors.initials: N
authors.lastname: Takayanagi
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: R
authors.initials: R
authors.lastname: Nagai
mesh_terms: D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D004365:Drugs, Chinese Herbal; C080903:sairei-to