Genetic analysis of synaptic development and plasticity: homeostatic regulation of synaptic efficacy.
When experimentally challenged with perturbations in synaptic structure and function, neurons have the remarkable ability to regulate their synaptic efficacy back to the normal range. Recent genetic analysis has provided insights into the mechanisms controlling this form of synaptic homeostasis, with implications for our understanding of synaptic development and plasticity.
Davis
G W
GW
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA. gdavis@coreys.berkeley.edu
Goodman
C S
CS
D000818:Animals; D002490:Central Nervous System / Q000254:growth & development* / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009473:Neuronal Plasticity / Q000235:genetics* / Q000502:physiology; D013569:Synapses / Q000502:physiology*