title: [Results of spectral determination of metals in human tissues adjacent to K.M. Sivash's endoprosthesis].
abstract: The paper presents the data of semiquantitative determination of metals in the tissues surrounding the total titanium-comochromium endoprosthesis of the Sivash system. The prostheses of this design which have a point of metal-metal friction have been used in the past 30 years. It has been shown that chromium and cobalt accumulate constantly and in great quantities, molybdenum and tin do less frequently and in lower quantities. Seventy tissue specimens were obtained from 20 patients followed up for 3 weeks to 15-19 years. The fine, highly sensitive method, emission spectral analysis, used by procedure developed by the Moscow Forensic Bureau of Experts was chosen. The study was undertaken to determine the association of the severity of metallosis with the aseptic instability of prostheses. However, there was no strong evidence for this: commensurable quantities of metals were found when permanent and temporary prostheses had been used. The author considers that the patients have not survived yet to have metallic instability that could have developed in some of them in the later periods of endoprosthesis use. Based on this and early studies, it is concluded that instability in the given periods is a result of mechanical action of some parts of the prostheses on bony formations. The findings show that the severity of metallosis depends on the number of cycles of prosthesis loading, which can be calculated by the duration of prosthesis use and the number of kilometers covered by the patient every day. The ascertained number of cycles may be correlated with the severity of metallosis expressed in arbitrary units.
authors.forename: K M
authors.initials: KM
authors.lastname: Sherepo
mesh_terms: D005500:Follow-Up Studies; D006622:Hip Prosthesis; D006801:Humans; D008670:Metals / Q000009:adverse effects* / Q000032:analysis; D011474:Prosthesis Design; D011475:Prosthesis Failure; D013057:Spectrum Analysis; D013997:Time Factors
chemical_list: D008670:Metals