title: [Anaphylactoid shock caused by chlorhexidine gluconate].
abstract: We report two cases of anaphylactoid shock caused by chlorhexidine gluconate. Both patients had skin flare, severe hypotension and increased airway pressure during cannulation of an antibacterial IVH catheter containing chlorhexidine gluconate after skin sterilization with chlorhexidine gluconate. In case 1, we did not identify the mechanism and causative drugs. In case 2, an intradermal test to chlorhexidine gluconate was positive 2 months later. Then we confirmed that the anaphylactoid shock was caused by chlorhexidine gluconate. We should bear in mind the risk of anaphylactoid shock when we use chlorhexidine gluconate or the IVH catheter containing the bactericide.
authors.affiliation: Department of Anesthesiology, Osaka Medical College, Takatsuki.
authors.forename: S
authors.initials: S
authors.lastname: Nikaido
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Yamoto
authors.forename: T
authors.initials: T
authors.lastname: Minami
authors.forename: M
authors.initials: M
authors.lastname: Akatsuka
authors.forename: H
authors.initials: H
authors.lastname: Mori
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002404:Catheterization / Q000009:adverse effects; D002710:Chlorhexidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D010289:Parenteral Nutrition, Total / Q000009:adverse effects
chemical_list: D000890:Anti-Infective Agents; C010882:chlorhexidine gluconate; D002710:Chlorhexidine