Antigenic homology of HIV-1 GP41 and human platelet glycoprotein GPIIIa (integrin beta3).
Fifty-eight of 89 serum samples (65.17%) from HIV-1-infected individuals at various disease stages contain antibodies that react with a platelet peptide located in the cytoplasmic domain of integrin beta3, glycoprotein GPIIIa (aa749-761; sequence DRKEFAKFEEERA). Rabbit polyclonal antibodies raised against the synthetic platelet peptide also react with the structurally homologous HIV-1 gp41-derived peptide (EKNEQELLELDKW(A)) and bind to a Western blot band with molecular weight corresponding to HIV-1 gp41. These findings point to molecular mimicry between HIV-1 and a human membrane protein found in platelets and other cells that could be of pathologic consequence.
Dominguez
V
V
Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, DF, Mexico.
Gevorkian
G
G
Govezensky
T
T
Rodriguez
H
H
Viveros
M
M
Cocho
G
G
Macotela
Y
Y
Masso
F
F
Pacheco
M
M
Estrada
J L
JL
Lavalle
C
C
Larralde
C
C
D000595:Amino Acid Sequence; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D000947:Antigens, Helminth / Q000737:chemistry / Q000276:immunology; D015153:Blotting, Western; D003551:Cysticercosis / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D015483:HIV Antibodies / Q000097:blood / Q000276:immunology; D015700:HIV Envelope Protein gp41 / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D015658:HIV Infections / Q000097:blood / Q000276:immunology; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1 / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D015801:Helminth Proteins / Q000276:immunology; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D039661:Integrin beta3; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000276:immunology; D010455:Peptides / Q000737:chemistry / Q000276:immunology; D010976:Platelet Count; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D011817:Rabbits; D017386:Sequence Homology, Amino Acid; D012698:Serologic Tests
D000909:Antibodies, Helminth; D015703:Antigens, CD; D000947:Antigens, Helminth; D000939:Epitopes; D015483:HIV Antibodies; D015700:HIV Envelope Protein gp41; D015801:Helminth Proteins; D007106:Immune Sera; D039661:Integrin beta3; D009842:Oligopeptides; D010455:Peptides; D010980:Platelet Membrane Glycoproteins