The effects of inflammation-mediated osteoporosis (IMO) on the skeletal Ca/P ratio and on the structure of rabbit bone and skin collagen.
The relationships between the skeletal Ca/P ratio (used as an index of bone quality) and structural changes in the bone and skin was studied in inflammatory mediated osteoporosis (IMO). The bone Ca/P ratio in IMO rabbits was significantly lower than in controls. Also, severe alterations were detected at the ultrastructural level in bone and skin collagen fibrils from IMO rabbits.
Fountos
G
G
Department of Medical Physics, Medical School, University of Ioannina, Greece.
Kounadi
E
E
Tzaphlidou
M
M
Yasumura
S
S
Glaros
D
D
D015502:Absorptiometry, Photon; D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D002118:Calcium / Q000032:analysis*; D003094:Collagen / Q000378:metabolism*; D005260:Female; D005720:Gamma Rays; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D007279:Injections, Subcutaneous; D017633:Magnesium Silicates / Q000008:administration & dosage; D010024:Osteoporosis / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D010710:Phosphates / Q000032:analysis*; D011817:Rabbits; D012016:Reference Values; D012867:Skin / Q000737:chemistry* / Q000473:pathology / Q000648:ultrastructure
D017633:Magnesium Silicates; D010710:Phosphates; C005013:Florisil; D003094:Collagen; D002118:Calcium