title: Synthesis of Cycleanine Mono-N-oxides
abstract: Oxidation of cycleanine (3) with m-chloroperbenzoic acid gave two diastereomeric N-oxides (1 and 2), and their stereochemistry was unambiguously determined on the basis of spectroscopic evidence. The NMR spectra of synthetic cycleanine mono-N-oxides 1 and 2 were significantly different from those of the natural product previously reported to be cycleanine N-oxide.
authors.affiliation: Research Laboratories, Kaken Shoyaku Co., Ltd., 3-37-10, Shimorenjaku, Mitaka-shi, Tokyo 181, Japan, and Showa College of Pharmaceutical Sciences, 3-3165, Higashi-Tamagawagakuen, Machida-shi, Tokyo 194, Japan.
authors.initials: N
authors.lastname: Kashiwaba
authors.initials: M
authors.lastname: Ono
authors.initials: J
authors.lastname: Toda
authors.initials: H
authors.lastname: Suzuki
authors.initials: T
authors.lastname: Sano