title: [Medical-scientific research in the elderly in The Netherlands; historic milestones and methodological problems].
abstract: OBJECTIVE
  To describe the methodological development of medical research regarding elderly subjects in the Netherlands.
  
  
  METHODS
  Descriptive.
  
  
  METHODS
  Nijmegen University, the Netherlands.
  
  
  METHODS
  All research on aging published in the Netherlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine) starting from its first volume in 1857 up to 1983 was studied. Selected were those articles in which new research methods were introduced. Next, six pioneering researchers in geriatrics were interviewed on the methodological development of geriatric research and on the problems they encountered in their own research.
  
  
  RESULTS
  Research started with studies on age-associated diseases such as prostatism, presbyacusis and senile dementia. It was only after a considerable delay that new diagnostic instruments such as electrocardiography and new research designs such as randomized trials found their way into research on elderly patients. The development of a questionnaire on the health of the elderly, the introduction of the concept of activities of daily living and of diagnostic instruments in the field of psychogeriatrics were important steps that made possible current geriatric research. From the outset, researchers encountered methodological problems still relevant in current research and caused by characteristics of geriatric patients: frailty, high prevalence of comorbidity, coexistence of physical, psychological and social problems, and large interindividual differences.
authors.affiliation: Academisch Ziekenhuis, afd. Klinische Geriatrie, Nijmegen.
authors.forename: M G
authors.initials: MG
authors.lastname: Olde Rikkert
authors.forename: G M
authors.initials: GM
authors.lastname: van Heteren
authors.forename: W H
authors.initials: WH
authors.lastname: Hoefnagels
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000375:Aging; D003704:Dementia / Q000503:physiopathology; D005260:Female; D005853:Geriatrics; D006304:Health Status; D006801:Humans; D008017:Life Expectancy; D008297:Male; D009426:Netherlands; D009735:Nursing Homes; D011304:Presbycusis / Q000503:physiopathology; D011470:Prostatic Hyperplasia / Q000503:physiopathology; D011581:Psychological Tests; D012107:Research Design