title: Deconstructing gelsolin: identifying sites that mimic or alter binding to actin and phosphoinositides.
abstract: Gelsolin is involved in cytoskeletal remodeling as it can fragment and guide reassembly of actin networks. Recent advances in defining the structure of gelsolin identified functionally important sites. These structural insights could lead to the design of small molecule analogs to enhance, inhibit or mimic the functions of gelsolin.
authors.affiliation: Experimental Medicine Division, Brigham and Women's Hospital, Boston, MA 02115, USA. janmey@calvin.bwh.harvard.edu
authors.forename: P A
authors.initials: PA
authors.lastname: Janmey
authors.forename: T P
authors.initials: TP
authors.lastname: Stossel
authors.forename: P G
authors.initials: PG
authors.lastname: Allen
mesh_terms: D000199:Actins / Q000378:metabolism*; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D003599:Cytoskeleton / Q000737:chemistry; D018260:Gelsolin / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D010716:Phosphatidylinositols / Q000378:metabolism*; D017510:Protein Folding; D017434:Protein Structure, Tertiary
chemical_list: D000199:Actins; D018260:Gelsolin; D010716:Phosphatidylinositols; D002118:Calcium