title: A computer controlled mock circulatory system for mono- and biventricular assist device testing.
abstract: The clinical use of heart assist devices for heart recovery, implies the problem of their in vitro testing and training to use. In a mock circulatory system developed to this aim, the main problem is reproducing interaction among the device, the ventricle and the circulatory network. This can be analysed by the position, on the p-v plane, of the working point defined by the intersection between end systolic ventricular (ESPVR) and arterial elastance lines. The system developed on this basis, connectable to mono- and biventricular parallel assist devices, was a closed loop model including systemic and pulmonary circulation. The arterial trees were reproduced by two windkessels with adjustable peripheral resistance, and the Starling's law of the heart by a variable elastance model. The software controls and monitors circulatory parameters and variables. Results showed the behavior of the system with preload or afterload changes. Further, the reproduction of physiological, pathological (obtained by modifying slope and volume intercept of the ESPVR line) and LVAD assisted circulatory conditions was shown. The assistance effect was underlined by the changes in the ventricular work cycle and in hemodynamics variables. The evaluation of the effect of device control strategy on the ventricle and its energetics (on p-v plane) were among the main characteristics of this system, which ought to be further improved to test devices such as the IABP, which requires a different aortic model.
authors.affiliation: Institute of Biomedical Technologies, CNR, Roma - Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: C
authors.initials: C
authors.lastname: De Lazzari
authors.forename: R
authors.initials: R
authors.lastname: Mimmo
authors.forename: G
authors.initials: G
authors.lastname: Tosti
authors.forename: D
authors.initials: D
authors.lastname: Ambrosi
authors.forename: K
authors.initials: K
authors.lastname: Gorczynska
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D003198:Computer Simulation; D004548:Elasticity; D006339:Heart Rate / Q000502:physiology; D006353:Heart-Assist Devices; D006801:Humans; D008955:Models, Cardiovascular; D010101:Oxygen Consumption / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology; D016276:Ventricular Function / Q000502:physiology