Cyclin A: function and expression during cell proliferation.
Cyclin A is a key regulatory protein which, in mammalian cells, is involved in both S phase and the G2/M transition of the cell cycle through its association with distinct cdks. Several lines of evidence have also implicated cyclin A in carcinogenesis. Our review concentrates on the role of cyclin A in S phase, in the S/G2 transition and in human carcinogenesis; it will also discuss the transcriptional regulation of cyclin A gene.
Desdouets
C
C
INSERM U370, Paris, France.
Sobczak-Thépot
J
J
Murphy
M
M
Bréchot
C
C
D002455:Cell Division; D019925:Cyclin A / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D016196:S Phase; D014158:Transcription, Genetic
D019925:Cyclin A