title: Dosimetric verification of the 95% isodose surface for a conformal irradiation technique.
abstract: In the treatment planning of conformal radiotherapy, field shapes are often designed in such a way that a high-value isodose surface fully encompasses the target volume. Therefore, knowledge about the accuracy with which the treatment planning system calculates the position of that isodose surface is essential to prevent field shapes which are either too large or too small. To determine this accuracy for a conformal multi-field technique, the dose in the high-dose region must be measured with a high spatial resolution. A method is presented to reconstruct and evaluate the experimental high-dose region from a set of water phantom scans. This method, which assesses combined dose profiles for multi-field irradiation techniques, can be used for the commissioning and/or quality assurance of a 3-D treatment planning system. For a specific conformal technique, the measured and calculated 95% isodose positions along lines in several directions have been compared. It is shown that different dose values of single beam profiles determine the resulting 95% isodose position, which is important to recognize for quality assurance of treatment planning calculations. It is further found that the uncertainty in the calculated 95% isodose surface can be described by a standard deviation in dose value, which relates to a positional uncertainty through the local dose gradient. Thus the confidence region of the calculated 95% isodose can be indicated in the treatment plan by plotting isodoses at the 95% level plus and minus its standard deviation. Such a procedure is recommended instead of plotting the 95% isodose with a constant width. In addition, restrictions for the cumulative dose-volume histogram of acceptable treatment plans can be formulated, based on the sensitivity of the actual target coverage on the uncertainty with which the prescribed isodose surface is calculated.
authors.affiliation: Radiotherapy Department, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Huis, Amsterdam, The Netherlands. brugmans@nki.nl
authors.forename: M J
authors.initials: MJ
authors.lastname: Brugmans
authors.forename: A
authors.initials: A
authors.lastname: van der Horst
authors.forename: J V
authors.initials: JV
authors.lastname: Lebesque
authors.forename: B J
authors.initials: BJ
authors.lastname: Mijnheer
mesh_terms: D001918:Brachytherapy / Q000379:methods* / Q000592:standards; D008279:Magnetic Resonance Imaging; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D011785:Quality Assurance, Health Care; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000592:standards; D015203:Reproducibility of Results; D014867:Water
chemical_list: D014867:Water