[Multiparametric model for regulating the rate of somatic cell proliferation].
A mathematical model is proposed, which describes the dependence of cell proliferation rate on the composition of culture medium. The model uses no kinetic relations. The main assumption of the model is that the modification of the composition of culture medium changes the properties of cells in the A-state of cell cycle. This results in changes in the rates of subsequent intracellular processes and hence of cell proliferation. Numerical results are presented, which characterize the behaviour of a model culture, which is similar in characteristics to the cell 3T3 cell culture. The results do not contradict the known facts and may be used for further development of the model.
Kudriavtsev
A A
AA
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
D016475:3T3 Cells; D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D003470:Culture Media; D051379:Mice; D008954:Models, Biological
D003470:Culture Media