Overcoming the unfavourable entropic contribution of ligand binding with a macrocyclic inhibitor bound to penicillopepsin.
Fraser
M E
ME
MRC Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, Canada.
Meyer
J H
JH
Bartlett
P A
PA
James
M N
MN
D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D008024:Ligands; D011480:Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
D008024:Ligands; D011480:Protease Inhibitors; C022325:aspartic proteinase A; D016282:Aspartic Acid Endopeptidases