title: [Diprivan as a component of the anesthesia in emergency surgical interventions in children].
abstract: Sixty-seven children aged 5-15 years were induced to narcosis and narcotized with diprivan. The patients were operated on for appendicitis, peritonitis, osteomyelitis, phlegmons of different localization, and craniocerebral injuries. For induction, diprivan was intravenously injected in a dose of 3-4 mg/kg. During the main narcosis (central analgesia with fentanyl in a total dose of 0.008 mg/kg/h) diprivan was infused by microjets in a dose of 6-9 mg/kg/h in combination with nitrogen oxide and oxygen in 1:1 ratio. Control group consisted of similar age-matched patients, to whom central analgesia without diprivan was administered. Respiration rate, heart rate, systolic and diastolic arterial pressure, mean arterial pressure (MAP), SaO2, and clinical course of anesthesia were examined at different stages of analgesia and surgery. During induction anesthesia the respiratory rate decreased by 27% and SaO2 decreased to 92.75 +/- 1.2% due to the specific effect of diprivan. MAP decreased by 4.8%. During the traumatic moment of surgery, respiratory rate increased by 20.1%, SaO2 was 98.25 +/- 0.24%, and heart rate increased by 22.6%. In the controls this period of surgery was associated with a more expressed reaction of the cardiovascular system, presenting as tachycardia (114.5 +/- 3.6) and increase of MAP by 10.1%. After anesthesia pain sensitivity returned earlier, due to which tachycardia and negligible hypertension were observed.
authors.forename: B D
authors.initials: BD
authors.lastname: Babaev
authors.forename: S A
authors.initials: SA
authors.lastname: Pivovarov
authors.forename: M V
authors.initials: MV
authors.lastname: Shishkov
authors.forename: N A
authors.initials: NA
authors.lastname: Akopian
authors.forename: D V
authors.initials: DV
authors.lastname: Afonin
authors.forename: E V
authors.initials: EV
authors.lastname: Moskovtseva
mesh_terms: D000293:Adolescent; D000770:Anesthesia, Endotracheal / Q000379:methods*; D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D002648:Child; D002675:Child, Preschool; D004630:Emergencies; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D015742:Propofol; D013514:Surgical Procedures, Operative / Q000379:methods*
chemical_list: D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D015742:Propofol