Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14.
Most somatic cell division cycles contain a gap period (G2 phase) between the completion of DNA synthesis and the initiation of mitosis. This delay of mitotic entry is controlled, at least in part, by the repression of Cdc2 kinase activity by the phosphorylation of two conserved residues (Thr14 and Tyr15) within the ATP-binding pocket of the Cdc2 catalytic subunit. The kinases responsible for these two phosphorylation events include the Myt1 and Wee1 kinases, which phosphorylate Cdc2 on Thr14 and Tyr15, respectively. In this discussion, we summarise our current knowledge of the Myt1 kinase and its regulation of Cdc2 kinase activity during the G2-to -M phase transition.
Fattaey
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Onyx Pharmaceuticals, Richmond, CA 94806, USA.
Booher
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D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D016203:CDC2 Protein Kinase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins; D016195:G2 Phase / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins; D008938:Mitosis / Q000502:physiology; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins; D013379:Substrate Specificity; D013912:Threonine / Q000737:chemistry; D014443:Tyrosine / Q000737:chemistry
D018797:Cell Cycle Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D029702:Schizosaccharomyces pombe Proteins; D013912:Threonine; D014443:Tyrosine; C068689:wee1 protein, S pombe; D011505:Protein-Tyrosine Kinases; C499349:WEE1 protein, human; C490679:PKMYT1 protein, human; D017346:Protein Serine-Threonine Kinases; D016203:CDC2 Protein Kinase