[Acute myocardial infarction following administration of a synthetic analog of prostaglandin E2 in a subject with an intramural course of the anterior intraventricular artery].
We report a case of acute myocardial infarction which occurred after administration of a synthetic analog of prostaglandin E2 (PGE2) for the voluntary interruption of pregnancy in a 31-year-old woman who had previously been asymptomatic, with myocardial bridging of the left anterior descending artery. The pathogenesis of the severe ischemia causing myocardial infarction and left ventricle aneurysm is quite unclear. The temporal connection is highly indicative of a causal relationship between the pharmacological effects of a synthetic PGE2 analog and coronary spasm responsible for severe ischemia. The hypothesis of endothelial dysfunction proximal to the intramyocardial artery tract and paradoxical vasoconstriction with platelet activation should be taken into consideration. A possible additional effect seems to be a horizontal coronary steal produced by the administration of PGE2 in the myocardium below the intramyocardial artery tract. It cannot be excluded that pharmacological doses of a synthetic analog of PGE2 may have inverted the vasoactive effects of the substance due to direct stimulation on the delivery of constrictive agonist factors.
Cocco
G
G
Divisione di Cardiologia, Azienda Ospedaliera, Ospedale San Salvatore, Pesaro.
Tarsi
G
G
Bersigotti
G
G
Sgarbi
E
E
D000019:Abortifacient Agents / Q000009:adverse effects*; D000208:Acute Disease; D000328:Adult; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006322:Heart Aneurysm / Q000209:etiology / Q000473:pathology; D006801:Humans; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011247:Pregnancy; D011459:Prostaglandins E, Synthetic / Q000009:adverse effects*
D000019:Abortifacient Agents; D011459:Prostaglandins E, Synthetic