title: Regulation of albumin mRNA and its promoter-binding nuclear factors under different perioperative nutritional methods in hepatectomized rats.
abstract: BACKGROUND
  Regulation of perioperative albumin synthesis under parenteral (PN) and enteral (EN) nutrition was investigated.
  
  
  METHODS
  Rats were divided into PN and EN groups. Both groups received the same regimen of artificial nutrition for 7 days and then underwent 70% hepatectomy. Serum albumin and mRNA levels of albumin and its promoter-binding nuclear factors (C/EBPalpha, beta, and DBP) were measured.
  
  
  RESULTS
  Serum albumin and albumin mRNA in the PN group were significantly lower than those in the EN group at 72 hours after hepatectomy. Preoperative and postoperative DBP and C/EBPalpha mRNA levels in the EN group were significantly higher than those in the PN group.
  
  
  CONCLUSIONS
  Serum albumin was well maintained by EN after hepatectomy owing to an early recovery of albumin mRNA level and its nuclear factor mRNA levels (C/EBPalpha and DBP). Compared with PN, EN is a more advantageous from of perioperative nutrition as pertains to albumin synthesis.
authors.affiliation: Department of Surgery II, Osaka University Medical School, Suita, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Morimoto
authors.forename: T
authors.initials: T
authors.lastname: Tsujinaka
authors.forename: M
authors.initials: M
authors.lastname: Yano
authors.forename: A
authors.initials: A
authors.lastname: Ogawa
authors.forename: M
authors.initials: M
authors.lastname: Kishibuchi
authors.forename: S
authors.initials: S
authors.lastname: Morita
authors.forename: H
authors.initials: H
authors.lastname: Shiozaki
authors.forename: M
authors.initials: M
authors.lastname: Monden
mesh_terms: D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D004750:Enteral Nutrition; D006498:Hepatectomy; D008297:Male; D009687:Nuclear Proteins / Q000096:biosynthesis*; D010288:Parenteral Nutrition; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000096:biosynthesis*; D013312:Stress, Physiological; D014157:Transcription Factors / Q000096:biosynthesis*
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C485975:DBP protein, rat; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D012333:RNA, Messenger; D012709:Serum Albumin; D014157:Transcription Factors