Altered colonic environment, a possible predisposition to colorectal cancer and colonic inflammatory bowel disease: rationale of dietary manipulation with emphasis on disaccharides.
A recurrent theme in the schema of pathogenetic mechanisms attributed to colorectal cancer (CRC) and inflammatory bowel disease (IBD) is the interaction between genes and environment. Dietary and other environmental factors, and lower intestinal flora and their chemical interactions occur in the pathogenesis of both. Events at the mucosal surface may be influenced by factors in the luminal environment and by contributions of the host. In addition, both forms of IBD--Crohn's disease (CD) and ulcerative colitis (UC)--have distinctive associated host events. Even within CD and UC, different clinical patterns and prognoses may have different specific host mechanisms. Some of the current putative pathogenetic processes in CRC and IBD are reviewed. Particular attention is given to hypotheses relating to the role of dietetic substances, mainly fibre and dairy products, and how they may affect disease formation. It is argued that within the context of hypotheses proposed for possible beneficial effects of these two dietetic factors, CRC and IBD may be considered together. Further support is lent to arguments that similar and additional hypothetical features ascribed to beneficial effects of fibre may be attributed to disaccharides, lactose and its derivatives, lactulose and lactitol.
Szilagyi
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Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, Faculty of Medicine, McGill University, Montreal, Quebec.
D015984:Causality; D003106:Colon / Q000382:microbiology / Q000502:physiology; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology; D003611:Dairy Products; D004043:Dietary Fiber; D004187:Disaccharides; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000209:etiology; D007787:Lactose Intolerance; D012307:Risk Factors
D004043:Dietary Fiber; D004187:Disaccharides