Heat shock proteins and arthritis--new readers start here.
The possible roles of heat shock proteins in the pathogenesis of inflammatory arthritis have been discussed for a number of years, and investigated intensively in both animal models and human disease. This review surveys evidence which has pointed, on the one hand, to hsp as targets of a pathogenic immune response, and on the other, to an immunoregulatory role for T cell recognition of self hsp. The extent to which findings in experimental animals have led to further insights applicable to human disease is also emphasised.
Gaston
J S
JS
Department of Medicine, University of Cambridge. jshg2@medschl.cam.ac.uk
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001171:Arthritis, Juvenile / Q000276:immunology; D016918:Arthritis, Reactive / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D004195:Disease Models, Animal; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans
D006360:Heat-Shock Proteins