Self-assembling bis-dendritic peptides: design, synthesis and characterization of oxalyl-linked bis-glutamyl peptides [Glu(n)(CO2Me)n + 1-CO-]2; n = 1,3,7.
Three generations of glutamic acid dendrons [Glu(n),(CO2Me)n + 1; n = 1, 3, 7] have been joined together head-to-head by an oxalyl unit to form highly sterically congested bis-Glu-dendritic peptides with gelling properties. The single crystal X-ray structure of the first generation bis-dendritic peptide showed an extended hydrogen-bonded chiral tape with modest nonlinear optical activity.
Ranganathan
D
D
Biomolecular Research Unit, Regional Research Laboratory (CSIR), Trivandrum, India.
Kurur
S
S
Madhusudanan
K P
KP
Roy
R
R
Karle
I L
IL
D018360:Crystallography, X-Ray; D018698:Glutamic Acid / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D011487:Protein Conformation
D010455:Peptides; D018698:Glutamic Acid