Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites.
In the course of our screening program for artemisinin-like antimalarial compounds from microorganisms, seven fungal metabolites such as radicicol and heptelidic acid were identified as active compounds. Some of them exhibited antimalarial activity in vitro against the human malaria parasite Plasmodium falciparum to the extent of approximately 1/10 as potent as artemisinin. Radicicol was moderately active in vivo against Plasmodium berghei in mice.
Tanaka
Y
Y
Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.
Shiomi
K
K
Kamei
K
K
Sugoh-Hagino
M
M
Enomoto
Y
Y
Fang
F
F
Yamaguchi
Y
Y
Masuma
R
R
Zhang
C G
CG
Zhang
X W
XW
Omura
S
S
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D005285:Fermentation; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D018942:Macrolides; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D000962:Antimalarials; D007783:Lactones; D018942:Macrolides; D012717:Sesquiterpenes; C027285:heptelidic acid; C035359:monorden