title: [Acute myocardial infarct following sulprostone administration].
abstract: Because of intrauterine foetal death at 35 weeks, parturition in a woman aged 35 years was induced by intravenous sulprostone. A few hours after its start she sustained a myocardial infarction for which she was treated. Coronary angiography 4 weeks later showed normal coronary arteries and good left ventricular function. Mild cardiovascular reactions such as bradycardia and mild hypotension are frequently observed adverse effects. In some instances, sulprostone can induce myocardial ischaemia. However, the possibility of a myocardial infarction is not mentioned in the product information of sulprostone. As there was an obvious temporal relationship and other causative factors were sufficiently excluded, the causal relation between the administration of sulprostone and the occurrence of myocardial infarction can be regarded as almost certain. Several experimental studies provide support for the hypothesis that coronary spasms play a major role in the pathophysiology of a myocardial infarction during the administration of sulprostone.
authors.affiliation: Inspectie voor de Gezondheidszorg, sectie Geneesmiddelenbewaking, Rijswijk.
authors.forename: J
authors.initials: J
authors.lastname: Feenstra
authors.forename: F
authors.initials: F
authors.lastname: Borst
authors.forename: M C
authors.initials: MC
authors.lastname: Huige
authors.forename: S G
authors.initials: SG
authors.lastname: Oei
authors.forename: B H
authors.initials: BH
authors.lastname: Stricker
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000208:Acute Disease; D000328:Adult; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000503:physiopathology; D015232:Dinoprostone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D004562:Electrocardiography; D005260:Female; D005313:Fetal Death; D006801:Humans; D007751:Labor, Induced; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000139:chemically induced*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; C016767:sulprostone; D015232:Dinoprostone