title: Anthelmintic efficacy of oxibendazole against some important nematodes in dogs and cats.
abstract: The anthelmintic efficacy and safety of the oxibendazole component in a combination oxibendazole-niclosamide paste were investigated in dogs and cats and in litters of pups with naturally acquired nematode infections. A single dose of 15 mg oxibendazole/kg body weight given to 70 dogs and to 29 cats reduced faecal worm egg counts (EPG) by 97.6% for Toxocara canis, 95.7% for Trichuris vulpis, 94.6% for Ancylostoma caninum, and 100% for Toxascaris leonina. In cats, 96.7% efficacy was demonstrated against Toxocara cati. In a second trial, 119 pups in 22 litters were treated with the same dosage at 2, 4, and 6 weeks of age. After treatment on two consecutive days, 95% of the pups did not shed T. canis eggs, compared with 85% after only a single treatment. Side effects were rare and only recorded in young animals. A 2-day treatment schedule is recommended for unweaned pups.
authors.affiliation: Virbac Nederland B.V., Barneveld, The Netherlands.
authors.forename: P A
authors.initials: PA
authors.lastname: Overgaauw
authors.forename: J H
authors.initials: JH
authors.lastname: Boersema
mesh_terms: D000722:Ancylostoma / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D000871:Anthelmintics / Q000627:therapeutic use*; D000969:Antinematodal Agents / Q000627:therapeutic use; D001562:Benzimidazoles / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D005260:Female; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009426:Netherlands; D009534:Niclosamide / Q000627:therapeutic use; D010270:Parasite Egg Count / Q000662:veterinary; D013532:Suriname; D014114:Toxascaris / Q000187:drug effects; D017166:Toxocara canis / Q000187:drug effects; D014258:Trichuris / Q000187:drug effects
chemical_list: D000871:Anthelmintics; D000969:Antinematodal Agents; D001562:Benzimidazoles; D004338:Drug Combinations; C011321:oxibendazole; D009534:Niclosamide