Inhibition of ornithine decarboxylase by ifenprodil.
Ifenprodil (NMDA receptor antagonist) was tested as an inhibitor of ornithine decarboxylase. It was found that ifenprodil inhibited ornithine decarboxylase activity with the same potency as alpha-difluoromethylornithine, a major inhibitor of ornithine decarboxylase. This result suggests that ifenprodil could target either the polyamine site on the NMDA receptor complex or/and polyamine biosynthesis.
Badolo
L
L
Laboratory of Bioanalytical Chemistry, Toxicology and Applied Physical Chemistry, Institute de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium.
Dubois
J
J
Helson-Cambier
M
M
Hanocq
M
M
D015317:Biogenic Polyamines / Q000378:metabolism; D000518:Eflornithine / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D065108:Ornithine Decarboxylase Inhibitors; D010880:Piperidines / Q000494:pharmacology*; D011700:Putrescine / Q000031:analogs & derivatives / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
D015317:Biogenic Polyamines; D004791:Enzyme Inhibitors; D018691:Excitatory Amino Acid Antagonists; C112324:N(1),N(4)-bis(benzyl)-N(1),N(4)-bis(methyl)putrescine; D065108:Ornithine Decarboxylase Inhibitors; D010880:Piperidines; D016194:Receptors, N-Methyl-D-Aspartate; C010739:ifenprodil; D011700:Putrescine; D000518:Eflornithine