Effect of hyperglycemia on pyruvate dehydrogenase activity and energy metabolites during ischemia and reperfusion in gerbil brain.
The effects of hyperglycemia on brain pyruvate dehydrogenase (PDH) and metabolites (ATP, PCr, and lactate) were investigated at 20 min ischemia, 0, 20, and 60 min, and 4 h reperfusion. During reperfusion, PDH activities were suppressed corresponding to the poor recovery of ATP and PCr concentrations and the increase in lactate concentration in the hyperglycemic group, suggesting that preischemic hyperglycemia may impair metabolism by suppressing PDH activity.
Katayama
Y
Y
The Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Fukuchi
T
T
Mc Kee
A
A
Terashi
A
A
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D005849:Gerbillinae; D006943:Hyperglycemia / Q000201:enzymology / Q000378:metabolism*; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000628:therapy*; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D015424:Reperfusion
D011768:Pyruvate Dehydrogenase Complex; D010725:Phosphocreatine; D019344:Lactic Acid; D000255:Adenosine Triphosphate