title: [Excessive terfenadine level due to drinking grapefruit juice].
abstract: Doctors who prescribe drugs should be aware not only of potential drug-drug interactions, but also of potential food-drug interactions. In particular, the ingestion of grapefruit juice leads to enhanced systemic bioavailability of terfenadine and of several important and frequently prescribed other drugs. Components of grapefruit juice interfere with the function of intestinal cytochrome P450 3A4, which degrades terfenadine. The resulting enhanced blood levels of terfenadine may lead to heart rate disturbances. Selling the drugs involved over the counter is consequently risky.
authors.affiliation: Afd. Kindergeneeskunde, Academisch Ziekenhuis Rotterdam-Sophia Kinderziekenhuis.
authors.forename: J N
authors.initials: JN
authors.lastname: van den Anker
authors.forename: S N
authors.initials: SN
authors.lastname: de Wildt
mesh_terms: D002957:Citrus / Q000009:adverse effects*; D004357:Drug Synergism; D018565:Food-Drug Interactions; D006801:Humans; D016593:Terfenadine / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D016593:Terfenadine