[Leiomyosarcoma of the spermatic cord with paraneoplastic beta-hCG production].
Leiomyosarcomas of the spermatic cord are very rare tumours, which, in contrast to the rhabdomyosarcoms of childhood, occur almost exclusively in adults. We report the case of a 51-year-old male patient with a metastasizing, pleomorphic leiomyosarcoma of the spermatic cord. The tumour showed paraneoplastic secretion of beta-chain human chorionic gonadotropin (beta-hCG), as was demonstrated by the elevated levels of beta-hCG in serum samples and by immunohistochemistry. Histologically, the tumour was a high-grade leiomyosarcoma which showed an aggressive course with pulmonary metastases appearing 4 months after primary surgery. A concomitant rise in the serum levels of beta-hCG was also noted at this time. A wide spectrum of tumours with a choriocarcinomatous component or paraneoplastic production of beta-hCG has been described, the vast majority being carcinomas. Only two leiomyosarcomas producing beta-hCG have so far been reported. The paraneoplastic production of beta-hCG should prevent confusion with germ-cell tumours, especially teratomas.
Seidl
C
C
Institut für Pathologie, Stadtkrankenhaus Worms.
Lippert
C
C
Grouls
V
V
Jellinghaus
W
W
D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000378:metabolism*; D017809:Fatal Outcome; D005834:Genital Neoplasms, Male / Q000378:metabolism / Q000473:pathology*; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D007890:Leiomyosarcoma / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013085:Spermatic Cord / Q000473:pathology*
D018997:Chorionic Gonadotropin, beta Subunit, Human; D006729:Hormones, Ectopic