title: Trichoflectin, a bioactive azaphilone from the ascomycete Trichopezizella nidulus.
abstract: Trichoflectin (1), a new azaphilone belonging to the deflectin series, 6-deoxy-7-0-demethyl-3,4-anhydrofusarubin (2), and 6-deoxy-3,4-anhydrofusarubin (3) were isolated from submerged cultures of the ascomycete Trichopezizella nidulus. All compounds showed antimicrobial activity and inhibited dihydroxynaphthalene melanin biosynthesis in fungi. The structure of trichoflectin (1) was elucidated by spectroscopic methods.
authors.affiliation: Department of Biotechnology, University of Kaiserslautern, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Thines
authors.forename: H
authors.initials: H
authors.lastname: Anke
authors.forename: O
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism; D001412:Bacillus subtilis; D001578:Benzopyrans / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001578:Benzopyrans; C111696:trichoflectin