Antifungal effects of new heterocyclic compounds, 6H-pyrimido[2,1-a]isoindole derivatives.
Minimal inhibitory concentrations for 10 new condensed isoindole derivatives were established by the agar diffusion method. Benzo[b]-6H-pyrimido[2,1-a]isoindole-4-one exhibited a broad antifungal effect; the observed MIC (mg/L) were 7 (K. lactis), 8 (C. pseudotropicalis), 17 (W. fluorescens), 22 (E. magnusii), 31 (P. membranaefaciens), 32 (S. alluvius) and 32 (S. cerevisiae). The compound also inhibited the growth of B. subtilis (MIC 9 mg/L). No effect on the growth of E. coli was found.
Nesmĕrák
K
K
Faculty of Science, Charles University, Prague, Czech Republic.
Pelouchová
H
H
Vsetecka
V
V
Nĕmec
I
I
Gabriel
J
J
D000935:Antifungal Agents / Q000494:pharmacology*; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology*
D000935:Antifungal Agents; D006575:Heterocyclic Compounds, 3-Ring; D006576:Heterocyclic Compounds, 4 or More Rings; D007211:Indoles; D011743:Pyrimidines