title: Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds.
abstract: The purpose of this study was to examine the association between experimental rhinovirus infection and the elaboration of interleukin-8 (IL-8) into nasal secretions of volunteers and to determine the effect of pentoxifylline on IL-8 elaboration and rhinovirus-associated common cold symptoms. Fifty-four subjects with experimental rhinovirus infections and 20 sham-inoculated subjects were studied. Pentoxifylline had no effect on rhinovirus-induced symptoms or nasal-secretion IL-8 concentrations. IL-8 concentrations were significantly greater in nasal secretions from infected symptomatic subjects than in those from infected asymptomatic or sham-challenged subjects on days 2-4 after virus challenge. In infected subjects, there was significant rank correlation between nasal obstruction severity, rhinorrhea severity, and nasal-wash albumin concentrations and the change in IL-8 concentration from baseline on days 2-4 after virus challenge.
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Turner
authors.forename: K W
authors.initials: KW
authors.lastname: Weingand
authors.forename: C H
authors.initials: CH
authors.lastname: Yeh
authors.forename: D W
authors.initials: DW
authors.lastname: Leedy
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D003139:Common Cold / Q000276:immunology* / Q000503:physiopathology* / Q000821:virology; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D008875:Middle Aged; D017817:Nasal Lavage Fluid; D010431:Pentoxifylline / Q000008:administration & dosage; D012229:Rhinovirus / Q000276:immunology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016209:Interleukin-8; D010431:Pentoxifylline