title: Clinic modelling randomised trials (CMRT's) in animals as a new intermediate between biological experiments and randomised clinical trials: application to antihistamine prophylaxis in anaesthesia and surgery.
authors.affiliation: Institute of Theoretical Surgery, Philipps University, Marburg, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Celik
authors.forename: W
authors.initials: W
authors.lastname: Lorenz
authors.forename: B
authors.initials: B
authors.lastname: Stinner
authors.forename: D
authors.initials: D
authors.lastname: Duda
authors.forename: H
authors.initials: H
authors.lastname: Sitter
authors.forename: S
authors.initials: S
authors.lastname: Sauer
authors.forename: A
authors.initials: A
authors.lastname: Junge
authors.forename: M
authors.initials: M
authors.lastname: Hoppe
mesh_terms: D000758:Anesthesia / Q000009:adverse effects; D000818:Animals; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use; D004115:Dimethindene / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D006636:Histamine Release / Q000187:drug effects; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D011292:Premedication; D016032:Randomized Controlled Trials as Topic; D011899:Ranitidine / Q000008:administration & dosage / Q000627:therapeutic use; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D013552:Swine; D013556:Swine, Miniature; D003189:p-Methoxy-N-methylphenethylamine
chemical_list: D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D003189:p-Methoxy-N-methylphenethylamine; D004115:Dimethindene; D002927:Cimetidine; D011899:Ranitidine