Oxidative damage, plasma antioxidant capacity, and glucemic control in elderly NIDDM patients.
A study of oxidative damage was made in elderly noninsulin-dependent diabetes mellitus (NIDDM) patients. A statistically significant increase in glucose and fructosamine was found in fasting NIDDM patients, as well as an increase in the oxidation induced by tert-butyl hydroperoxide. The Total Reactive Antioxidant Potential (TRAP) of the plasma was much reduced (p < .02) and the uricemia was unchanged. The erythrocytes of diabetic patients show greater basal oxidation products (p < .05), and the susceptibility of the diabetic erythrocytes to oxidation injury was also shown to increase in the oxidation induced by t-BOOH (p < .05). Linear regression studies showed that TRAP was associated directly with uric acid (p < .05) and inversely with fructosamine and with glucose (p < .03 and p < .05 respectively) in patients with NIDDM, but not in the controls. The levels of fructosamine were found to be related to the basal damage of the red blood cells (direct correlation, p < .001). This study suggest an useful approach to diabetic oxidative stress for clinical settings.
Aguirre
F
F
Hospital de Clínicas José de San Martin, Universidad de Buenos Aires, Argentina.
Martin
I
I
Grinspon
D
D
Ruiz
M
M
Hager
A
A
De Paoli
T
T
Ihlo
J
J
Farach
H A
HA
Poole
C P
CP
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D005215:Fasting; D019270:Fructosamine / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010545:Peroxides / Q000494:pharmacology; D014527:Uric Acid / Q000097:blood; D020122:tert-Butylhydroperoxide
D000975:Antioxidants; D001786:Blood Glucose; D008055:Lipids; D010545:Peroxides; D014527:Uric Acid; D019270:Fructosamine; D020122:tert-Butylhydroperoxide