The effect of gentamicin on acetylsalicylic acid-induced platelet antiaggregatory action in mouse pial arterioles.
Gentamicin (G) treatment (5, 20, 40 and 80 mg kg[-1] day[-1] given intramuscularly for 6 days) was shown to cause a dose-related platelet proaggregatory effect in mouse pial microcirculation. This was associated with a reduction in mouse renal function, indicated by high plasma creatinine and urea concentrations. When G was given at the same doses but as a single injection, it caused no change in renal function or platelet aggregation. Gentamicin (20 and 80 mg kg/day, given intramuscularly for 6 days) significantly (P < 0.05) impeded the platelet antiaggregatory effect of acetylsalicylic acid (100 mg kg[-1], intraperitoneally).
El-Sabban
F M
FM
Faculty of Medicine & Health Sciences, UAE University, Al-Ain.
Ali
B H
BH
Bashir
A K
AK
Tanira
M O
MO
D000818:Animals; D001160:Arterioles / Q000187:drug effects; D001241:Aspirin / Q000494:pharmacology*; D004347:Drug Interactions; D005839:Gentamicins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010841:Pia Mater / Q000098:blood supply*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D005839:Gentamicins; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin