Effect of ibuprofen and diclofenac sodium on experimental would healing.
Effects of frequently used anti-inflammatory drugs ibuprofen and diclofenac was studied on experimental wound healing in rats. These drugs impede tissue repair by virtue of retarding inflammation. There was 16-36% reduction in wound strength measured in terms of tensile strength in experimental rats. The detrimental effect of anti-inflammatory drugs was confirmed by histological examination of wound and by measuring dry granuloma weight.
Dvivedi
S
S
Department of General Surgery, G R Medical College, Gwalior, India.
Tiwari
S M
SM
Sharma
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D005260:Female; D007052:Ibuprofen / Q000494:pharmacology*; D008297:Male; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D007052:Ibuprofen