The role of robustness and changeability on the origin and evolution of genetic codes.
We propose that an essential factor on the origin of genetic codes is a balanced accomplishment of robustness and changeability, two antithetical, but fundamental, properties for the survival and evolution of organisms. These measures are defined as the intrinsic properties of genetic codes. An evaluation of these properties explains the structural regularity of genetic codes, estimates the order of codon reassignment in deviant codes, and predicts the most probable deviant codes that exist. The enumeration of genetic codes that could have evolved from the standard genetic code under the selection pressure on robustness and changeability strongly limits the freedom of codon reassignments. The codon reassignments of all currently known deviant genetic codes belong to this predicted evolutionary path, and they generally give the highest improvements on robustness and changeability.
Maeshiro
T
T
Department 6, ATR Human Information Processing Research Laboratories, 2-2 Hikaridai, Seika, Soraku, Kyoto, 619-0237 Japan.
Kimura
M
M
D000596:Amino Acids / Q000737:chemistry; D005075:Biological Evolution; D005815:Genetic Code; D008954:Models, Biological; D009154:Mutation; D010443:Peptide Chain Termination, Translational; D017384:Sequence Deletion; D012995:Solubility
D000596:Amino Acids