Stability of perfluorocarbon emulsions and their compatibility with blood serum.
There is not enough to study of the perfluorocarbon (PFC) emulsions particle size only for judgment the question about their stability and quality. It is essential to evaluate also the structure alteration of PFC emulsions and their compatibility with the blood serum. It was shown that stability of PFC emulsion of the same composition depend on the mode of their preparing. The particle size of frozen PFC emulsions as a rule does not change at storage and their compatibility with blood serum can remain unchanged. However, the integrity of particle structure of PFC emulsions may be destroyed at unfreezing. The average diameter of PFC emulsion particles may remain unchanged at storage, but the compatibility with blood serum may become worse.
Kuznetsova
I N
IN
Laboratory of Blood Substitutes, Russian Research Institute of Hematology and Transfusiology, St. Petersburg, Russia.
D001798:Blood Proteins / Q000737:chemistry*; D003102:Colloids; D004356:Drug Storage; D004655:Emulsions; D005466:Fluorocarbons / Q000737:chemistry*; D005615:Freezing; D009391:Nephelometry and Turbidimetry; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry; D011060:Poloxalene / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry
D001798:Blood Proteins; D003102:Colloids; D004655:Emulsions; D005466:Fluorocarbons; D010743:Phospholipids; D013501:Surface-Active Agents; D014867:Water; C039422:perfluorotripropylamine; C008807:perfluorotributylamine; C008805:perfluorodecalin; D011060:Poloxalene