HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato.
Three new oligostilbenes, malibatols A (1) and B (2) and dibalanocarpol (3), together with one known oligostilbene balanocarpol (4), were isolated from the organic extract of the leaves of Hopea malibato. The structure elucidation of these compounds was based on the interpretation of their chemical and spectral data. Compounds 3 and 4 exhibited very modest HIV-inhibitory activity, while compounds 1 and 2 were cytotoxic to the host cells (CEM SS) in the antiviral assay.
Dai
J R
JR
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Hallock
Y F
YF
Cardellina
J H
JH
Boyd
M R
MR
D019380:Anti-HIV Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D006678:HIV / Q000187:drug effects; D006801:Humans; D008969:Molecular Sequence Data; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013267:Stilbenes / Q000302:isolation & purification* / Q000494:pharmacology
D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; C111736:dibalanocarpol; C111734:malibatol A; C111735:malibatol B