title: The application of GnRH analogues in the treatment of uterine myomas in perimenopausal women.
abstract: Our objective was to determine whether long GnRH agonists induce effective and persistent shrinkage of uterine myomas in perimenopausal women, as well as to determine the usefulness of Doppler sonography study in evaluating the therapy benefit. The study covers 30 patients with symptomatic myomas in perimenopausal period. We used long GnRH agonist-Decapeptyl (Ferring) at 28 days intervals in the course of 4 months. After discontinuing the application of Decapeptyl, medroxyprogesterone acetate was introduced for 6 months. The GnRH/gestagens therapy is useful and effective in treatment of symptomatic myomas in perimenopausal patients, and may be a valid alternative to hysterectomy. Doppler sonography is reliable in monitoring of uterine circulation in patients under GnRH therapy.
authors.affiliation: Narodni front, Obstetrics Gynaecology University Clinic, Belgrade, Yugoslavia.
authors.forename: S
authors.initials: S
authors.lastname: Dragojević-Dikić
authors.forename: M
authors.initials: M
authors.lastname: Vućić
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017697:Premenopause; D017329:Triptorelin Pamoate / Q000008:administration & dosage*; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017329:Triptorelin Pamoate