The mammalian Golgi apparatus during M-phase.
The Golgi apparatus in mammalian cells disassembles into several thousand vesicles as cells enter M-phase. Disassembly is dependent on the action of cdc2-kinase and at least two pathways contribute to the fragmentation: One involves the budding of COP-coated vesicles from Golgi cisternae with concomitant inhibition of fusion with their target membranes, the other is a less well characterised COP-independent pathway. During telophase, the Golgi fragments reassemble and fuse into a fully functional Golgi stack, using at least two distinct fusion pathways. The morphological changes of the Golgi apparatus during M-phase offer an ideal system to study how cellular organelles are generated and how their structure is maintained during interphase.
Misteli
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Cold Spring Harbor Laboratory, NY 11724, USA.
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D007399:Interphase / Q000502:physiology; D008322:Mammals; D008561:Membrane Fusion / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D008854:Microscopy, Electron; D008938:Mitosis / Q000502:physiology*
D008565:Membrane Proteins; D016203:CDC2 Protein Kinase