HIV hyperimmune globulin or intravenous immune globulin inhibits response to an HIV vaccine.
The murine model was developed to assess the effects of maternally transferred HIV hyperimmune globulin or human intravenous immune globulin on the immunization of the offspring at 18-21 days of age with rgp 120SF2-complete Freund's adjuvant. Either HIV hyperimmune globulin or intravenous immune globulin was administered intraperitoneally to post-partum BALB/c mice and was transferred via milk to the offspring. Both HIV hyperimmune globulin and intravenous immune globulin inhibited the offspring anti-rgp 120SF2 IgG response to the vaccine. The HIV hyperimmune globulin inhibition persisted for 28 days after immunization while the intravenous immune globulin inhibition was still present at 63 days after immunization. In addition, the intravenous immune globulin had a more generalized immunosuppressive effect, inhibiting the IgG response to both rpg 120SF2 and an additional protein antigen, hen egg-white lysozyme. Effects of maternal or exogenously administered pre-existing antibody, including control antibodies (intravenous immune globulin), on the newborn response to HIV and other vaccines must be carefully evaluated when vaccine studies proceed in newborns.
Jelonek
M T
MT
Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance 90509, USA.
Maskrey
J L
JL
Cummins
L M
LM
Arora
Y
Y
Steimer
K S
KS
White-Scharf
M
M
Keller
M A
MA
D016915:AIDS Vaccines / Q000276:immunology / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D015483:HIV Antibodies / Q000494:pharmacology*; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D006801:Humans; D007112:Immunity, Maternally-Acquired / Q000187:drug effects*; D007074:Immunoglobulin G / Q000032:analysis / Q000187:drug effects; D016756:Immunoglobulins, Intravenous / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data
D016915:AIDS Vaccines; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous