title: [18F]fluoride PET indicates reduced bone formation in severe glucocorticoid-induced osteoporosis.
abstract: A 61-year-old female patient presenting with mixed connective tissue disease (Sharp syndrome), underwent a long-term high dose glucocorticoid treatment because of multiple organ manifestations. Under steroid therapy she developed severe osteoporosis resulting in multiple fractures. A dynamic [18F]fluoride PET study in this patient revealed reduced fluoride influx in non-fractured vertebrae. This finding corresponds to pathogenetic concepts which propose an inhibition of bone formation as major cause of glucocorticoid-induced osteoporosis. In the light of the presented case it seems to be promising to evaluate the diagnostic benefit of [18F]fluoride PET in osteoporosis.
authors.affiliation: Klinik für Nuklearmedizin, Medizinischen Hochschule Hannover, Germany. berding.georg@mh-hannover.de
authors.forename: G
authors.initials: G
authors.lastname: Berding
authors.forename: T D
authors.initials: TD
authors.lastname: Kirchhoff
authors.forename: W
authors.initials: W
authors.lastname: Burchert
authors.forename: J
authors.initials: J
authors.lastname: von der Hoff
authors.forename: H
authors.initials: H
authors.lastname: Zeidler
authors.forename: H
authors.initials: H
authors.lastname: Hundeshagen
authors.forename: W H
authors.initials: WH
authors.lastname: Knapp
mesh_terms: D004947:Esophagus / Q000000981:diagnostic imaging; D005260:Female; D005459:Fluorides; D005462:Fluorine Radioisotopes; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000209:etiology; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000009:adverse effects*; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D010024:Osteoporosis / Q000139:chemically induced / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D012129:Respiratory Function Tests; D013669:Technetium Tc 99m Medronate; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D005938:Glucocorticoids; D019275:Radiopharmaceuticals; D005459:Fluorides; D008775:Methylprednisolone; D013669:Technetium Tc 99m Medronate