title: TMC-49A, a novel transcriptional up-regulator of low density lipoprotein receptor, produced by Streptomyces sp. AS1345.
abstract: Microbial metabolites were screened for a transcriptional up-regulator of low density lipoprotein (LDL) receptor by a reporter assay. TMC-49A was discovered as an up-regulator obtained from the fermentation broth of Streptomyces sp. AS1345. The structure of TMC-49A was elucidated to be butyl N-phenethylcarbamate by spectroscopic analyses. This compound enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay. Taxonomy of the producing strain is also described.
authors.affiliation: Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Koguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Asai
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Nishio
authors.forename: N
authors.initials: N
authors.lastname: Yanaka
authors.forename: K
authors.initials: K
authors.lastname: Omori
authors.forename: T
authors.initials: T
authors.lastname: Ohnuki
authors.forename: S
authors.initials: S
authors.lastname: Komatsubara
mesh_terms: D002219:Carbamates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D006801:Humans; D011973:Receptors, LDL / Q000096:biosynthesis / Q000187:drug effects* / Q000378:metabolism; D013302:Streptomyces; D014158:Transcription, Genetic / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects; D014520:Urethane / Q000031:analogs & derivatives*
chemical_list: D002219:Carbamates; D011973:Receptors, LDL; C111759:TMC 49A; D014520:Urethane