Cell cycle control of DNA replication.
The cell cycle is driven by the sequential activation of a family of cyclin-dependent kinases (cdk), which phosphorylate and activate proteins that execute events critical to cell cycle progression. In mammalian cells cdk2-cyclin A has a role in S phase. Many replication proteins are potential substrates for this cdk kinase, suggesting that initiation, elongation and checkpoint control of replication could all be regulated by cdk2. The association of PCNA, a replication protein, with cdk-cyclins during G-1 to S phase transition and with cdk-cyclin inhibitors, adds an interesting complexity to regulation of DNA replication.
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Institut de Biologie Structurale J.-P. Ebel, Grenoble, France.
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D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D018844:Cyclin-Dependent Kinases / Q000502:physiology*; D016213:Cyclins / Q000502:physiology; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000502:physiology; D004789:Enzyme Activation; D006801:Humans; D010441:Peptide Chain Elongation, Translational; D010442:Peptide Chain Initiation, Translational; D051716:Replication Protein A; D016196:S Phase
D018797:Cell Cycle Proteins; D016213:Cyclins; D004268:DNA-Binding Proteins; C497167:RPA1 protein, human; D051716:Replication Protein A; D018844:Cyclin-Dependent Kinases