title: Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for beta-thalassemia major.
abstract: OBJECTIVE
  Donor lymphocyte infusion (DLI) was used to reverse relapse after allogeneic bone marrow transplantation (BMT) in a patient with beta-thalassemia major.
  
  
  METHODS
  The patient with unstable mixed chimerism after BMT was treated with graded increments of donor lymphocytes (10(5) T cells/kg to 5 x 10(7) T cells/kg) to displace residual hematopoietic host cells.
  
  
  RESULTS
  DLI resulted in complete donor-derived reconstitution of the hematopoietic compartment. The patient developed mild graft-versus-host disease (GVHD) that could be controlled by steroid treatment.
  
  
  CONCLUSIONS
  This case report shows that DLI can effectively eradicate host stem cells in mixed chimeras after BMT in nonmalignant hematopoietic diseases.
authors.affiliation: Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Aker
authors.forename: J
authors.initials: J
authors.lastname: Kapelushnik
authors.forename: T
authors.initials: T
authors.lastname: Pugatsch
authors.forename: E
authors.initials: E
authors.lastname: Naparstek
authors.forename: S
authors.initials: S
authors.lastname: Ben-Neria
authors.forename: O
authors.initials: O
authors.lastname: Yehuda
authors.forename: A
authors.initials: A
authors.lastname: Amar
authors.forename: A
authors.initials: A
authors.lastname: Nagler
authors.forename: S
authors.initials: S
authors.lastname: Slavin
authors.forename: R
authors.initials: R
authors.lastname: Or
mesh_terms: D016026:Bone Marrow Transplantation / Q000276:immunology*; D002675:Child, Preschool; D002678:Chimera; D006086:Graft vs Host Disease / Q000188:drug therapy; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D017710:Lymphocyte Transfusion; D008297:Male; D017086:beta-Thalassemia / Q000628:therapy*