title: Chemosensory event-related potentials change with age.
abstract: The study examined age-related changes in the perception of olfactory and trigeminal chemical stimuli using chemosensory event-related potentials (CSERP). Three groups of healthy volunteers, each comprised of 8 men and 8 women, were tested (age ranges 15-34, 35-54, and 55-74 years). Subjects underwent extensive psychological testing focusing on impairments of memory and attention. In addition, odor identification and discrimination ability was evaluated, as well as detection threshold sensitivity for two odorants. Odor discrimination scores exhibited a significant age-related decrease. Significant age-related changes were also observed for CSERP N1P2 and P2 amplitudes, and for the N1 peak latency. The age-related decrease of CSERP amplitudes appeared to follow a different time course for responses to trigeminal and olfactory stimulants.
authors.affiliation: Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Erlangen, Germany. hummeltc@compuserve.com
authors.forename: T
authors.initials: T
authors.lastname: Hummel
authors.forename: S
authors.initials: S
authors.lastname: Barz
authors.forename: E
authors.initials: E
authors.lastname: Pauli
authors.forename: G
authors.initials: G
authors.lastname: Kobal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009619:Nociceptors / Q000502:physiology*; D009812:Odorants; D018035:Receptors, Odorant / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D012903:Smell / Q000502:physiology*; D014276:Trigeminal Nerve / Q000502:physiology
chemical_list: D018035:Receptors, Odorant