title: Painful hyperplasia and hypertrophy of pacinian corpuscles in the hand: report of two cases with immunohistochemical and ultrastructural studies, and a review of the literature.
abstract: Hypertrophy and hyperplasia of pacinian corpuscles in the hand are very rare, with only 29 cases previously published. We describe two new cases in middle-aged patients whose chief complaint was progressive digital pain. Immunohistochemical and electronmicroscopic investigations indicated that the lump replicates the structure of enlarged pacinian corpuscles and should not be considered as a real tumor, nor connected to neurofibromatosis. No recurrence was observed after surgical excision. Although local trauma was encountered in 55% of the reported cases, the pathogenesis of such a lesion is still speculative.
authors.affiliation: Department of Neuropathology, Centre Hospitalier Universitaire de Liège, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Reznik
authors.forename: A
authors.initials: A
authors.lastname: Thiry
authors.forename: V
authors.initials: V
authors.lastname: Fridman
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006229:Hand Dermatoses / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology*; D006984:Hypertrophy / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010141:Pacinian Corpuscles / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D009418:S100 Proteins / Q000032:analysis
chemical_list: D015415:Biomarkers; D009418:S100 Proteins