title: Why do children have chronic abdominal pain, and what happens to them when they grow up? Population based cohort study.
abstract: OBJECTIVE
  To test the hypotheses that children with abdominal pain have anxious parents and come from families with high rates of physical illness and that they grow up to suffer from high rates of medically unexplained symptoms and psychiatric disorders.
  
  
  METHODS
  Population based birth cohort study.
  
  
  METHODS
  General population.
  
  
  METHODS
  Participants in the Medical Research Council (MRC) national survey of health and development, a population based birth cohort study established in 1946.
  
  
  METHODS
  Abdominal pain present throughout childhood in the absence of defined organic disease, and measures of physical symptoms and psychiatric disorder at age 36 years.
  
  
  RESULTS
  There were high rates of complaints about physical health among the parents of children with persistent abdominal pain, and the mothers had higher neuroticism scores. Children with persistent abdominal pain were more likely to suffer from psychiatric disorders in adulthood (odds ratio 2.72 (95% confidence interval 1.65 to 4.49)) but were not especially prone to physical symptoms once psychiatric disorder was controlled for (odds ratio 1. 39 (0.83 to 2.36)).
  
  
  CONCLUSIONS
  Persistent abdominal pain is associated with poor health and emotional disorder in the parents. Children with abdominal pain do not necessarily continue to experience physical symptoms into adulthood but are at increased risk of adult psychiatric disorders.
authors.affiliation: Department of Psychological Medicine, King's College School of Medicine and Dentistry and Institute of Psychiatry, London SE5 8AZ, UK. m.hotopf@iop.bpmf.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Hotopf
authors.forename: S
authors.initials: S
authors.lastname: Carr
authors.forename: R
authors.initials: R
authors.lastname: Mayou
authors.forename: M
authors.initials: M
authors.lastname: Wadsworth
authors.forename: S
authors.initials: S
authors.lastname: Wessely
mesh_terms: D015746:Abdominal Pain / Q000453:epidemiology*; D000041:Absenteeism; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015331:Cohort Studies; D004739:England / Q000453:epidemiology; D005192:Family Health; D005500:Follow-Up Studies; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology*; D009497:Neurotic Disorders / Q000453:epidemiology; D011379:Prognosis; D012008:Recurrence; D012606:Scotland / Q000453:epidemiology; D017678:Sex Distribution; D012923:Social Class; D014852:Wales / Q000453:epidemiology