Antitumor effect of polysaccharide coated liposomal adriamycin on AH66 hepatoma in nude mice.
Drug delivery systems play a crucial role in cancer chemotherapy, not only in the achievement of sufficient tumoricidal effect but also in minimizing systemic side effects. We investigated the effect of liposomal adriamycin with tumor recognition molecule, 1-aminolactose (1-AL), on AH66 hepatoma transplanted into nude mice. Adriamycin (ADM) was encapsulated in liposome coating with cholesterol pullulan (CHP) to increase the stability in the blood stream. 1-AL was assembled to the outer layer of CHP-coated liposomal ADM as a tumor recognition molecule. In an in vivo therapeutic study. 1-AL/CHP-coated liposomal ADM restrained tumor growth more when compared with CHP-coated liposomal ADM. Thus, 1-AL/CHP-coated liposome seems to be a carrier of ADM to tumor cells.
Ichinose
K
K
Second Department of Surgery, Nagasaki University, Japan.
Yamamoto
M
M
Khoji
T
T
Ishii
N
N
Sunamoto
J
J
Kanematsu
T
T
D000818:Animals; D002240:Carbohydrate Sequence; D004317:Doxorubicin / Q000008:administration & dosage*; D005936:Glucans; D008081:Liposomes; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D051381:Rats; D013329:Structure-Activity Relationship; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
D005936:Glucans; D008081:Liposomes; D004317:Doxorubicin; C009109:pullulan