Sodium nitrite alone protects the brain microsomal Ca(2+)-ATPase against potassium cyanide-induced neurotoxicity in rats.
The effect of a short-term oral administration of potassium cyanide (KCN) (200 ppm in diet) with or without sodium nitrite (NaNO2) pretreatment on rat brain microsomal Ca2 +/- ATPase was investigated. The specific activity value of the enzyme significantly decreased (p < 0.05) by 50% compared with control and by 63% for KCN-treated rats compared with KCN-treated rats pretreated with NaNO2. There was no significant difference at the h = 0.05 level between the values obtained for the control and KCN-treated rats pretreated with NaNO2. These results show both that feeding lowers brain microsomal Ca(2+)-ATPase activity and that NaNO2 has a protective role (antidote function) in that respect.
Odunuga
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OO
Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria.
Adenuga
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GA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology*; D011190:Potassium Cyanide / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite / Q000008:administration & dosage / Q000494:pharmacology*
D000252:Calcium-Transporting ATPases; D012977:Sodium Nitrite; D011190:Potassium Cyanide