[Effect of probiotics from bacilli on macrophage functional activity].
The influence of new probiotics from bacilli i.e. biosporin and subalin on the functional activity of murine peritoneal macrophages was studied. After a single oral administration of the probiotics the maximum activation of the macrophages was observed in 4 hours. The activation level depended on both the dose and the probiotic. The highest value of the stimulation index was recorded with subalin. Analogous regularities were stated with parenteral administration of the probiotics. Some mechanisms of activation of peritoneal macrophages after oral administration of probiotics from live microbial cultures are discussed.
Sorokulova
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IB
Institute of Microbiology and Virology, National Academy of Sciences of the Ukraine, Kiev.
D000284:Administration, Oral; D000818:Animals; D001407:Bacillus / Q000737:chemistry*; D001412:Bacillus subtilis / Q000737:chemistry*; D001685:Biological Factors / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D019936:Probiotics / Q000302:isolation & purification / Q000494:pharmacology*
D001685:Biological Factors; C091592:biosporin; C112120:subalin