Insulin resistance, dehydroepiandrosterone sulfate and sex hormone-binding globulin in essential hypertension.
OBJECTIVE
To evaluate insulin sensitivity, and serum levels of sex hormone-binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEA-sulfate), in patients with essential hypertension.


METHODS
In 15 non-treated hypertensive patients, insulin resistance was measured by an insulin suppression test (IST). Serum levels of DHEA-sulfate and SHBG were measured at the beginning and at the end of the IST. The results were compared to those of a control group of 10 healthy normotensive subjects matched for age, sex and body mass index (BMI).
Serrano-Gotarredona
J
J
Department of Endocrinology, Hospital General Universitario de Alicante, Spain.
Escobar-Morreale
H F
HF
Sancho
J M
JM
García-Robles
R
R
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013004:Somatostatin
D001786:Blood Glucose; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013004:Somatostatin; D019314:Dehydroepiandrosterone Sulfate