Emergence of antimicrobial resistance in community-acquired pulmonary pathogens.
Antibiotic resistance to the common respiratory tract pathogens is increasing worldwide. Penicillin-resistant pneumococci are of particular concern. Most strains of penicillin-resistant Streptococcus pneumoniae have intermediate resistance to penicillin, and highly resistant strains are rare at present. Careful selection of antibiotics with low resistance potential and excellent activity against highly penicillin-resistant pneumococci (ie, cefotaxime, ceftriaxone, cefepime, cefprozil, doxycycline, levofloxacin, sparfloxacin, and meropenem) is the best current strategy to delay or increase the emergence of highly penicillin-resistant strains of S pneumoniae.
Cunha
B A
BA
Infectious Disease Division, Winthrop-University Hospital, Mineola, NY 11501, USA.
Shea
K W
KW
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D001936:Moraxella catarrhalis / Q000187:drug effects; D011014:Pneumonia / Q000188:drug therapy* / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects
D000900:Anti-Bacterial Agents