Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
Scalfaro
P
P
Division of Neonatology, University Hospital, Lausanne, Switzerland.
Chesaux
J J
JJ
Buchwalder
P A
PA
Biollaz
J
J
Micheli
J L
JL
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000378:metabolism; D000293:Adolescent; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D005260:Female; D006679:HIV Seropositivity / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008657:Metabolic Clearance Rate; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D015215:Zidovudine / Q000009:adverse effects* / Q000493:pharmacokinetics
D019380:Anti-HIV Agents; D015215:Zidovudine