The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE.
Large scale human epidemiological studies indicate that high intakes of linoleic acid protect against the development of cancer. One mechanism may be the generation of 13-HODE from linoleic acid. 13-HODE prevents cell adhesion to endothelial cells and can inhibit cancer metastasis. 13-HODE synthesis is enhanced by cyclic AMP. Gamma-linolenic acid, a desaturated metabolite of linoleic acid, causes substantial stimulation of 13-HODE synthesis. A fall in gamma-linolenic acid synthesis with age may be related to the age-related fall in 13-HODE formation.
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Scotia Research Institute, Stirling, Scotland.
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D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002448:Cell Adhesion; D000242:Cyclic AMP / Q000378:metabolism; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D019787:Linoleic Acid / Q000502:physiology* / Q000627:therapeutic use*; D008041:Linoleic Acids / Q000502:physiology*; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D017965:gamma-Linolenic Acid / Q000378:metabolism
D016588:Anticarcinogenic Agents; D008041:Linoleic Acids; C024348:13-hydroxy-9,11-octadecadienoic acid; D017965:gamma-Linolenic Acid; D019787:Linoleic Acid; D000242:Cyclic AMP