Effect of sorbitol on the phosphate adsorptive capacity of ferrihydrite suspensions.
The purpose of this study was to stabilize the phosphate adsorptive capacity of aqueous suspensions of ferrihydrite, a potential phosphate binder. Ferrihydrite was precipitated by the addition of 1 N NaOH to 1 M FeCl3 until pH 8.0 was reached. The ferrihydrite suspension was divided into three portions and an amount of sorbitol was added to produce sorbitol concentrations of 0, 1, or 5% w/v, respectively. The phosphate adsorptive capacity and X-ray diffraction pattern were periodically determined during aging at room temperature. The phosphate adsorptive capacity of the ferrihydrite suspension containing 0% sorbitol decreased steadily from 0.012 mgP/mg to 0.007 mgP/mg during the 1-year aging period. In contrast, suspensions containing 1 or 5% sorbitol exhibited constant phosphate adsorptive capacities during this period. X-ray diffraction patterns revealed that ferrihydrite transformed to hematite and goethite during aging of the control suspension. The presence of 1 or 5% sorbitol prevented the transformation of ferrihydrite to more crystalline iron oxides. This study suggests that the phosphate adsorptive capacity of ferrihydrite suspensions can be stabilized by the incorporation of small amounts of sorbitol into the formulation.
Gruenhagen
S E
SE
Department of Agronomy, Purdue University, West Lafayette, Indiana 47907, USA.
Schulze
D G
DG
Chansiri
G
G
Hem
K J
KJ
White
J L
JL
Hem
S L
SL
D000327:Adsorption; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004355:Drug Stability; D005290:Ferric Compounds; D005293:Ferritins / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D013012:Sorbitol / Q000737:chemistry*; D013535:Suspensions; D013816:Thermodynamics; D014961:X-Ray Diffraction
D005290:Ferric Compounds; D010710:Phosphates; D013535:Suspensions; D013012:Sorbitol; C092844:ferric oxyhydroxide; D005293:Ferritins