[Successful treatment of hepatocellular carcinoma with All-trans-retinoic acid].
A 44-year-old female patient was admitted to our department with diagnosis of malignant lymphoma. The abdominal USG and CT showed multiple liver lesions with partial portal vein thrombosis, moderately increased alfa-fetoprotein (AFP), ASAT, ALAT (2x normal value), serology was negative for HBV and HCV. Liver transplantation was suggested but refused because of portal vein thrombosis. ATRA (45 mg/m2/day orally) was given on the basis of the assumption that HCC and acute promyelocytic leukaemia share similar oncogenic pathway (alter the RAR alpha and beta receptors). She was gained 15 kg-s and has resumed her work as a teacher for the last 20 months. Abdominal CT showed a complete regression of the intrahepatic tumour.
Egyed
M
M
Kaposi Mór Megyei Kórház, Kaposvár, Belgyógyászati Osztály.
Nyárádi
A
A
Boros
B
B
Viski
A
A
Kelle
M
M
Puskás
A
A
Kocsis
T
T
Horváth
G
G
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014212:Tretinoin / Q000627:therapeutic use*; D014463:Ultrasonography
D000970:Antineoplastic Agents; D014212:Tretinoin