title: Malignant histiocytic disorders in children. Clinical and therapeutic approaches with a nosologic discussion.
abstract: Malignant histiocytic disorders, other than leukemias, are extremely rare in childhood. Despite unresolved nosologic and terminologic difficulties, they should be classified according to the lineage of the aberrant cells in a given tumor. There are no common and typical clinical presentations, nor are there established treatment modalities available. For the disseminated forms, aggressive systemic treatment modalities--similar if not identical to those used for large cell anaplastic lymphomas--appear to be the best treatment option. For the localized forms, which are primarily dendritic cell sarcomas, a more localized and individualized therapy is appropriate.
authors.affiliation: Department of Paediatrics, Medical University of Lübeck, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Bucsky
authors.forename: R M
authors.initials: RM
authors.lastname: Egeler
mesh_terms: D002648:Child; D002675:Child, Preschool; D054747:Histiocytic Sarcoma / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans