[Platelet hemostatic changes in patients with chronic alcoholism stage II in rest and exercise].
Platelet hemostasis was studied in 23 patients with chronic alcoholism (CA) stage II at rest and under muscular exercise. At rest, the patients had elevated spontaneous aggregation of platelets and more active start of adrenaline and ristomycin aggregation. Exercise stimulated spontaneous platelet aggregation, enhances adrenaline and ristomycin aggregation. According to adrenalin test 32% of the examinees had platelet dysfunction. According to ristomycin aggregation, vascular endothelium was impaired in 95.7%of the patients. Thus, it is evident that CA stage II patients develop disorder of platelet hemostasis and vascular endothelium. Such patients are at high risk of thrombogenesis.
Koriakin
A M
AM
Epifantseva
N N
NN
Kovalenko
V M
VM
Gorbatovskiĭ
Ia A
IaA
Karagaeva
L G
LG
Solodkov
L V
LV
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D000900:Anti-Bacterial Agents; D002908:Chronic Disease; D004837:Epinephrine; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D012310:Ristocetin; D012720:Severity of Illness Index; D014662:Vasoconstrictor Agents
D000900:Anti-Bacterial Agents; D014662:Vasoconstrictor Agents; D012310:Ristocetin; D004837:Epinephrine