title: Donor primordial germ cell-derived offspring from recipient germline chimaeric chickens: absence of long-term immune rejection and effects on sex ratios.
abstract: 1. Germline chimaeric chickens were produced by the transfer of primordial germ cells, and the generation of donor-derived offspring was examined for a maximum of 146 weeks. 2. The frequencies of donor-derived offspring from the chimaeras were 47% to 97%, and no apparent changes in frequency were observed with increasing age during the test period. 3. Differentiation of donor primordial germ cells into functional gametes appeared to be restricted to a degree at some developmental stage in the gonads of chimaeric chickens of the opposite sex.
authors.affiliation: National Institute of Animal Industry, University of Tsukuba, Ibaraki, Japan. mnaito@niai.affrc.go.jp
authors.forename: M
authors.initials: M
authors.lastname: Naito
authors.forename: A
authors.initials: A
authors.lastname: Tajima
authors.forename: Y
authors.initials: Y
authors.lastname: Yasuda
authors.forename: T
authors.initials: T
authors.lastname: Kuwana
mesh_terms: D000818:Animals; D001947:Breeding / Q000379:methods; D002645:Chickens / Q000235:genetics* / Q000276:immunology; D002678:Chimera; D005260:Female; D005854:Germ Cells / Q000637:transplantation*; D006085:Graft Survival; D008297:Male; D012099:Reproductive Techniques / Q000662:veterinary; D012744:Sex Ratio