title: [Immunology in clinical practice. XI. IgG receptors: the role of polymorphism in autoimmune and infectious diseases].
abstract: Receptors for the constant part of IgG (Fc gamma R) are implicated in the pathogenesis of a number of diseases. Children from mothers with an Fc gamma RIIIb deficiency may suffer from neonatal neutropenia due to an alloimmune reaction. Interindividual differences (polymorphisms) for a number of Fc gamma R represent risk factors for several infectious and autoimmune diseases. Immunotherapeutic use of several monoclonal antibody subclasses is affected by Fc gamma R polymorphisms. Fc gamma R can be used for cellular entrance by lymphotropic viruses (such as HIV) and appear to be involved in the pathogenesis of fulminant Dengue virus infections.
authors.affiliation: Academisch Ziekenhuis, Afd. Immunologie, Utrecht.
authors.forename: W L
authors.initials: WL
authors.lastname: van der Pol
authors.forename: E J
authors.initials: EJ
authors.lastname: Kuijper
authors.forename: H R
authors.initials: HR
authors.lastname: Koene
authors.forename: M
authors.initials: M
authors.lastname: de Haas
authors.forename: E A
authors.initials: EA
authors.lastname: Sanders
authors.forename: J G
authors.initials: JG
authors.lastname: van de Winkel
mesh_terms: D000818:Animals; D019067:Antibody-Dependent Enhancement; D015703:Antigens, CD / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007239:Infections / Q000276:immunology*; D051379:Mice; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology*; D012307:Risk Factors; D014181:Transplantation Immunology
chemical_list: D015703:Antigens, CD; D017452:Receptors, IgG