Effects of slime produced by clinical isolates of coagulase-negative staphylococci on activities of various antimicrobial agents.
A novel in vitro semiquantitative method was developed to investigate the influence of staphylococcal slime on the activities of 22 antimicrobial agents. Pefloxacin, teicoplanin, and vancomycin demonstrated remarkable decreases in efficacy: 30, 52, and 63%, respectively. The activity of rifampin was not significantly reduced (0.99%), whereas all other agents tested were modestly affected (<15% decrease). These data could be influential in the treatment of implant-associated infections caused by slime-producing staphylococci.
Souli
M
M
First Department of Propedeutic Medicine, Laiko General Hospital, Athens University School of Medicine, Greece.
Giamarellou
H
H
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D003030:Coagulase / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D011134:Polysaccharides / Q000378:metabolism / Q000494:pharmacology*; D013210:Staphylococcus / Q000201:enzymology / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003030:Coagulase; D011134:Polysaccharides