title: Synthesis and biological activity of 11,19-bridged progestins.
abstract: A synthetic approach to 11,19-bridged progestins is described. The key step in the synthesis is a 6-endo-trig radical cyclisation. The new progestins were tested for their biological activities in vitro and in vivo and compared to those of known progestins.
authors.affiliation: Research Laboratories of Schering AG, Berlin, Germany. wolfgang.schwede@schering.de
authors.forename: W
authors.initials: W
authors.lastname: Schwede
authors.forename: K H
authors.initials: KH
authors.lastname: Fritzemeier
authors.forename: W
authors.initials: W
authors.lastname: Halfbrodt
authors.forename: R
authors.initials: R
authors.lastname: Krattenmacher
authors.forename: P
authors.initials: P
authors.lastname: Muhn
authors.forename: G
authors.initials: G
authors.lastname: Neef
authors.forename: E
authors.initials: E
authors.lastname: Ottow
authors.forename: K
authors.initials: K
authors.lastname: Schöllkopf
mesh_terms: D000818:Animals; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011247:Pregnancy; D011372:Progestins / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D013739:Testosterone / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D011372:Progestins; D011944:Receptors, Androgen; D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone; D013739:Testosterone