title: Hepatoprotection with Glycosmis pentaphylla (Retz).
abstract: Effects of extracts of leaf (250, 500 and 750 mg/kg body wt) and stem bark (100, 200 and 400 mg/kg body wt) of G. pentaphylla were studied on CCl4 (1 mg/kg body wt) induced hepatic injury in albino rats. Parameters studied were plasma ALAT, ASAT, ALP, total bilirubin and tissue histopathology. Recovery of hepatic tissue was indicated with the highest dose (750 mg/kg body wt) of leaf extract. The therapeutic dose range was devoid of toxic effects. Toxicity of leaf extract was observed histopathologically at and above 2.5g/kg body wt.
authors.affiliation: Department of Zoology, College of Science and Technology, Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Mitra
authors.forename: R K
authors.initials: RK
authors.lastname: Sur
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D007194:India; D007565:Jaundice / Q000188:drug therapy; D008099:Liver / Q000187:drug effects*; D008297:Male; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D010936:Plant Extracts