title: Pathology slide review in gynecologic oncology.
abstract: OBJECTIVE
  To analyze the diagnostic accuracy and alteration in treatment planning from interinstitution (different institution) pathologic consultation.
  
  
  METHODS
  We reviewed pathologic reports from 720 referred patients. The diagnosis rendered from a gynecologic pathologist was compared with the original diagnosis. Discrepancies were coded as none, minor, or major. A discrepancy was major if it led to treatment alteration. A discrepancy was minor if it did not lead to treatment alteration. The judgment to declare a discrepancy was made by a gynecologic pathologist, a gynecologist, and three gynecologic oncologists. The review cost was $150 per case. The Cochran-Mantel-Haenszel test evaluated any systematic pattern in discrepancies.
  
  
  RESULTS
  Seven hundred twenty specimens consisted of 113 vulvar, 170 uterine, 289 cervical, 105 ovarian, and 43 vaginal tissues. Six hundred one (84%) pathologic diagnoses showed no discrepancy. There were 104 (14%) minor and 15 (2%) major discrepancies. After reviewing 15 major discrepancies, six surgeries were canceled, two surgeries were modified, one adjuvant radiation treatment was added, one chemotherapy treatment was modified, and five adjuvant chemotherapy treatments were cancelled. No systematic error was identified with regard to the sources (tissue origin) or methods of obtaining the specimen (P = .675). The cost of reviewing 720 specimens was $108,000. The cost of identifying each major discrepancy was $7200.
  
  
  CONCLUSIONS
  Reviewing pathology slides before definitive treatment reveals notable discrepancies in diagnoses. The cost of pathology review is globally expensive but has consequential impact on proper treatment planning for the individual patient.
authors.affiliation: Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas 77555-0587, USA. jtsantos@utmb
authors.forename: J T
authors.initials: JT
authors.lastname: Santoso
authors.forename: R L
authors.initials: RL
authors.lastname: Coleman
authors.forename: R L
authors.initials: RL
authors.lastname: Voet
authors.forename: S G
authors.initials: SG
authors.lastname: Bernstein
authors.forename: S
authors.initials: S
authors.lastname: Lifshitz
authors.forename: D
authors.initials: D
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003362:Cost-Benefit Analysis; D003581:Cytodiagnosis / Q000191:economics; D003951:Diagnostic Errors; D005260:Female; D005831:Genital Diseases, Female / Q000175:diagnosis* / Q000191:economics / Q000628:therapy; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000628:therapy; D005836:Genitalia, Female / Q000473:pathology*; D006176:Gynecology; D006801:Humans; D008495:Medical Oncology; D008875:Middle Aged; D015588:Observer Variation; D010338:Pathology, Clinical / Q000191:economics