Interfacial properties as stability predictors of lecithin-stabilized perfluorocarbon emulsions.
The purpose of this study was to determine whether the addition of small quantities of minor lecithin components (phosphatidylinositol, phosphatidic acid, lysophosphatidylethanolamine, and cholesterol) and Pluronic F68 to lecithin could improve the stability of lecithin-stabilized perfluorocarbon emulsions. Attempts were made to correlate emulsion stability with interfacial properties (tension and charge). Dynamic interfacial tension was determined using a Teflon Wilhelmy plate method [reported previously (1)]. Emulsions were prepared by microfluidization. Microelectrophoresis was used to measure emulsion droplet charge, and photon correlation spectroscopy and Coulter analysis were used to determine emulsion stability as a function of droplet size. Thermal kinetic accelerated stability testing was conducted. Various droplet size parameters were used to compare emulsion stabilities, and an overall stability ranking, based on these parameters, was obtained for each emulsion. Small quantities of additives altered emulsion stability and these data were correlated with interfacial properties and initial droplet diameters. The addition of cholesterol to lecithin resulted in the most stable perfluorocarbon emulsion.
Yoon
J K
JK
Department of Pharmaceutics, College of Pharmacy, University of Illinois at Chicago 60612, USA.
Burgess
D J
DJ
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002784:Cholesterol; D004355:Drug Stability; D004655:Emulsions; D005079:Excipients / Q000737:chemistry*; D005466:Fluorocarbons; D010713:Phosphatidylcholines / Q000737:chemistry*; D011060:Poloxalene; D013499:Surface Properties; D013501:Surface-Active Agents; D013696:Temperature
D004655:Emulsions; D005079:Excipients; D005466:Fluorocarbons; D010713:Phosphatidylcholines; D013501:Surface-Active Agents; D011060:Poloxalene; D002784:Cholesterol