Antigastric autoantibodies and gastric secretory function in Helicobacter pylori-infected patients with duodenal ulcer and non-ulcer dyspepsia.
BACKGROUND
Autoantibodies against epitopes located at the canaliculi of human parietal cells occur in about 30% of Helicobacter pylori-infected patients. This has led to the hypothesis that gastric secretory function could be inhibited by anticanalicular autoantibodies in H. pylori gastritis.


METHODS
Forty-four H. pylori-infected patients with and without duodenal ulcers were screened for anticanalicular autoantibodies by means of immunohistochemistry. Plasma gastrin levels and basal and maximal gastric acid output were determined.


RESULTS
Fasting gastrin levels were significantly increased in the group with anticanalicular autoantibodies. In the group of patients with non-ulcer dyspepsia the presence of anticanalicular autoantibodies was significantly correlated with an impaired basal acid secretion.


CONCLUSIONS
Antigastric autoimmunity in H. pylori gastritis seems to be relevant for gastric hyposecretion either directly by inhibiting the proton pump or indirectly through the development of gastric mucosa atrophy.
Faller
G
G
Institute of Pathology and Dept. of Internal Medicine I, University of Erlangen-Nürnberg, Erlangen, Germany.
Winter
M
M
Steininger
H
H
Konturek
P
P
Konturek
S J
SJ
Kirchner
T
T
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D015551:Autoimmunity; D004381:Duodenal Ulcer / Q000378:metabolism / Q000382:microbiology; D004415:Dyspepsia / Q000378:metabolism / Q000382:microbiology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000276:immunology* / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000378:metabolism* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000276:immunology* / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000276:immunology
D001323:Autoantibodies; D005755:Gastrins