Mycobacterium leprae binds to a 25-kDa phosphorylated glycoprotein of human peripheral nerve.
Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from human peripheral nerve. This protein is phosphorylatable and it binds to lectins which have alpha-mannose specificity. This M leprae-protein interaction could be of importance in the pathogenesis of leprosy.
Suneetha
L M
LM
Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, TN, India.
Satish
P R
PR
Korula
R J
RJ
Suneetha
S K
SK
Job
C K
CK
Balasubramanian
A S
AS
D001345:Autoradiography; D001426:Bacterial Proteins / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D004926:Escherichia coli / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000378:metabolism; D008970:Molecular Weight; D009163:Mycobacterium bovis / Q000378:metabolism; D009166:Mycobacterium leprae / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding; D013979:Tibial Nerve / Q000378:metabolism*
D001426:Bacterial Proteins; D006023:Glycoproteins; D037102:Lectins; D009419:Nerve Tissue Proteins