title: Progressive presumed choriocapillaris atrophy after surgery for age-related macular degeneration.
abstract: OBJECTIVE
  The authors sought to evaluate the progression of presumed choriocapillaris atrophy after surgical excision of a subfoveal choroidal neovascular membrane (CNV) in an 80-year-old man with age-related macular degeneration.
  
  
  METHODS
  The CNV was excised using a conventional three-port vitrectomy with subretinal dissection. The excised tissue was studied with light and electron microscopy. Preoperative and serial postoperative fluorescein angiograms (FA) and fundus photographs were obtained to study the dissection bed.
  
  
  RESULTS
  Seven days after surgery, the FA showed hyperfluorescence in the area previously occupied by the CNV. Six weeks after surgery, this area showed retinal pigment epithelium (RPE) depigmentation, atrophy, or both on clinical examination, and the FA showed presumed choriocapillaris nonperfusion. Seven months after surgery, the area of the RPE depigmentation or atrophy and the corresponding area of presumed choriocapillaris nonperfusion had enlarged. The area of depigmentation or atrophy continued to enlarge for 1 year after surgery. Histologically, the excised CNV specimen disclosed RPE cells but no choriocapillaris.
  
  
  CONCLUSIONS
  Presumed choriocapillaris nonperfusion after CNV excision may be due to RPE removal at surgery and may progress postoperatively.
authors.affiliation: University of Medicine and Dentistry, New Jersey Medical School, Department of Ophthalmology, Newark 07103-2499, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Castellarin
authors.forename: M
authors.initials: M
authors.lastname: Nasir
authors.forename: I K
authors.initials: IK
authors.lastname: Sugino
authors.forename: M A
authors.initials: MA
authors.lastname: Zarbin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001284:Atrophy; D002196:Capillaries / Q000473:pathology; D002829:Choroid / Q000098:blood supply*; D018450:Disease Progression; D006801:Humans; D008268:Macular Degeneration / Q000150:complications*; D008297:Male; D009389:Neovascularization, Pathologic / Q000150:complications* / Q000601:surgery*; D010857:Pigment Epithelium of Eye / Q000473:pathology; D011183:Postoperative Complications