Neuropeptides in the livers of mice during bacterial infections.
Neuropeptides such as substance P (SP) and vasoactive intestinal peptide (VIP) are known to act as immunomodulators. We investigated the induction of SP and VIP in the livers of mice infected with Listeria monocytogenes or injected with Tsukamurella paurometabolum. VIP was detected in the livers of mice after L. monocytogenes infection by an immunohistochemical technique and preproVIP mRNA, which was detected by reverse transcription-polymerase chain reaction (PCR), was induced post infection. However, no SP was detected. In contrast, SP, but not VIP was detected within granulomas in the livers of T. paurometabolum-injected mice, suggesting VIP and SP might be selectively induced in the liver by different bacterial infections.
Nakane
A
A
Department of Bacteriology, Hirosaki University School of Medicine, Aomori, Japan. a27k03n0@cc.hirosaki-u.ac.jp
Asano
M
M
Miura
T
T
Sasaki
S
S
Nishikawa
S
S
Kohanawa
M
M
Minagawa
T
T
D000192:Actinomycetales; D000193:Actinomycetales Infections / Q000378:metabolism*; D000818:Animals; D005260:Female; D008088:Listeriosis / Q000378:metabolism*; D008099:Liver / Q000737:chemistry*; D051379:Mice; D011498:Protein Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D013373:Substance P / Q000032:analysis*; D014660:Vasoactive Intestinal Peptide / Q000032:analysis* / Q000235:genetics
D011498:Protein Precursors; D012333:RNA, Messenger; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; C055594:preprovasoactive intestinal peptide