title: Predictive significance of magnetic resonance imaging at 4 months of adjusted age in infants after a perinatal neurologic insult.
abstract: The aim of this prospective study was to evaluate the predictive significance of magnetic resonance imaging (MRI) performed at 4 months of corrected age in 60 neonates after a perinatal neurologic insult. Follow-up ranged from 2 to 5 years of chronological age. MRI examination was normal in 10; isolated external hydrocephalus was found in 15 infants. Twenty-three of these infants developed normally. Focal or multifocal lesions were shown in 6 infants, of whom 2 developed normally. Diffuse brain involvement was present in 29 cases as atrophy (n = 18), leukomalacia (n = 5), basal ganglia lesions (n = 3), and delayed myelination (n = 3). All but 4 infants showed neurologic impairment. MRI performed at 4 months of adjusted age is of prognostic significance in neonates who suffer a moderate or mild neurologic insult.
authors.affiliation: Neonatal Unit, Hôpital d'Enfants, C.H.U. Timone, Marseille, France.
authors.forename: V
authors.initials: V
authors.lastname: Millet
authors.forename: J M
authors.initials: JM
authors.lastname: Bartoli
authors.forename: V
authors.initials: V
authors.lastname: Lacroze
authors.forename: C
authors.initials: C
authors.lastname: Raybaud
authors.forename: D
authors.initials: D
authors.lastname: Unal
authors.forename: N
authors.initials: N
authors.lastname: Girard
mesh_terms: D001479:Basal Ganglia / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D006849:Hydrocephalus / Q000473:pathology; D007231:Infant, Newborn; D007234:Infant, Premature; D007969:Leukomalacia, Periventricular / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009186:Myelin Sheath / Q000502:physiology; D009422:Nervous System Diseases / Q000473:pathology*; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors