[Circulatory arrest following sulprostone administration in postpartum hemorrhage].
In a woman aged 39 cardiac arrest occurred 3.5 hours after administration of 250 micrograms sulprostone directly into the uterine wall for a post-partum haemorrhage after manual removal of the placenta. A long period of resuscitation was necessary. After further evaluation the woman demonstrated specific contraindications to the administration of sulprostone. as formulated by the French authorities: age > 35 years, heavy cigarette smoking, and cardiovascular risk factors. In the Netherlands sulprostone is registered for intravenous administration only. We would strongly advise against administration directly into the uterine wall.
Beerendonk
C C
CC
Afd. Obstetrie-Gynaecologie, Academisch Ziekenhuis, Nijmegen.
Massuger
L F
LF
Lucassen
A M
AM
Lerou
J G
JG
van den Berg
P P
PP
D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects*; D000328:Adult; D003329:Coronary Vasospasm / Q000139:chemically induced; D015232:Dinoprostone / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy*; D011247:Pregnancy; D012151:Resuscitation; D012307:Risk Factors; D014693:Ventricular Fibrillation / Q000139:chemically induced*
D000020:Abortifacient Agents, Nonsteroidal; C016767:sulprostone; D015232:Dinoprostone