title: Effect of topical cyclosporin A on Thygeson's superficial punctate keratitis.
abstract: Thygeson's superficial punctate keratitis (Thygeson's SPK) is a distinct clinical entity, characterized by round conglomerates of discrete, granular, white-gray, fine intraepithelial dots without conjunctival involvement. The only effective treatment with regard to relieving symptoms and diminishing lesions has been topical corticosteroids, but their prolonged use can be associated with severe side-effects. The purpose of this study is to present the long-term results of the use of 2% topical cyclosporin A in olive oil in Thygeson's SPK. Eight patients diagnosed as having Thygeson's SPK were included. All the patients were treated with 2% cyclosporin dissolved in olive oil four times a day for three months, and two times a day for one month before withdrawing therapy. The follow-up period ranged from twelve to twenty-five months. The number of corneal lesions varied between 5 and 15 before treatment. After cyclosporin treatment, no corneal lesion was observed and the cornea remained clear after the follow-up period. In conclusion, 2% cyclosporin in olive oil is a safe alternative to corticosteroids in the treatment of Thygeson's SPK, and resulted in satisfactory control of the condition.
authors.affiliation: Instituto de Investigaciones Oftalmologicas Ramon Castroviejo, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Del Castillo
authors.forename: J B
authors.initials: JB
authors.lastname: Del Castillo
authors.forename: J
authors.initials: J
authors.lastname: Garcia-Sanchez
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007634:Keratitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D009883:Ophthalmic Solutions; D010938:Plant Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D007166:Immunosuppressive Agents; D000069463:Olive Oil; D009883:Ophthalmic Solutions; D010938:Plant Oils; D016572:Cyclosporine