Increased striatal dopamine production from L-DOPA following selective inhibition of monoamine oxidase B by R(+)-N-propargyl-1-aminoindan (rasagiline) in the monkey.
Striatal extracellular fluid concentrations of dopamine and metabolites in response to direct striatal administration of two L-DOPA boluses administered sequentially were determined in three rhesus monkeys during halothane anesthesia. Whereas in an initial microdialysis run, generation of dopamine was less following the second L-DOPA bolus than the first, in a subsequent run, in which the selective MAO-B inhibitor R(+)-N-propargyl-1-aminoindan (rasagiline) was administered systemically (0.2 mg/kg s.c.) between the two L-DOPA boluses, generation of dopamine was greater following the second bolus.
Finberg
J P
JP
Clinical Neurosciences Branch, NINDS, NIH, Bethesda, MD, USA.
Wang
J
J
Bankiewicz
K
K
Harvey-White
J
J
Kopin
I J
IJ
Goldstein
D S
DS
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D007189:Indans / Q000494:pharmacology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D007980:Levodopa / Q000378:metabolism*; D008253:Macaca mulatta; D017551:Microdialysis; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*
D007189:Indans; D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; C031967:rasagiline; D015102:3,4-Dihydroxyphenylacetic Acid; D007980:Levodopa; D008995:Monoamine Oxidase; D004298:Dopamine; D006719:Homovanillic Acid