title: Isolation of 1-Methylherbipoline Salts of Halisulfate-1 and of Suvanine as Serine Protease Inhibitors from a Marine Sponge, Coscinoderma mathewsi
abstract: Bioassay-guided isolation of serine protease inhibitors from a marine sponge, Coscinoderma mathewsi, has yielded 1-methylherbipoline salts of halisulfate-1 and of suvanine. Structures of these compounds were identified by spectroscopic analyses and literature data. Antithrombin and antitrypsin activity was determined.
authors.affiliation: Department of Chemistry, College of Science and Engineering, Aoyama Gakuin University, 6-16-1 Chitosedai, Setagaya, Tokyo, 157, Japan, Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822-2275, and The Natural History Museum, Cromwell Road, London SW7 5BD, U.K.
authors.initials: J
authors.lastname: Kimura
authors.initials: E
authors.lastname: Ishizuka
authors.initials: Y
authors.lastname: Nakao
authors.initials: WY
authors.lastname: Yoshida
authors.initials: PJ
authors.lastname: Scheuer
authors.initials: M
authors.lastname: Kelly-Borges