[Allogeneic bone marrow transplantation of unrelated donors; fewer complication, more donors].
A female patient aged 37 years who suffered from chronic myeloid leukemia received an allogeneic bone marrow transplantation (BMT) from an HLA-matched unrelated donor. No life-threatening complications ensued; 2.5 years after BMT she is still in complete remission. Survival after BMT from an unrelated donor for the time being is still lower than that after BMT from a related donor, but is improving due to better prevention and treatment of opportunistic infections and better selection of registered donors by meticulous HLA matching.
Liem
G S
GS
Academisch Ziekenhuis Rotterdam-Daniel, Hoed Kliniek, afd. Hematologie.
Cornelissen
J J
JJ
Oudshoorn
M
M
Sintnicolaas
K
K
Löwenberg
B
B
Hagenbeek
A
A
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006650:Histocompatibility Testing; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D009894:Opportunistic Infections / Q000517:prevention & control; D011379:Prognosis; D012074:Remission Induction; D014019:Tissue Donors