title: Delusional disorder and eye tracking dysfunction: preliminary evidence of biological and clinical heterogeneity.
abstract: This study used eye tracking movement tests to examine the relationships between frontal field functions and clinical features. Smooth pursuit and voluntary saccadic eye movements were recorded and analyzed in 34 delusional disorder (DD) patients and in 40 normal subjects. The DD group differed significantly from the group of normal subjects in some eye tracking performances. As reported in our previous study (Gambini et al., 1993), DD patients showed abnormalities of voluntary saccadic eye movements. In this study, we also found abnormal smooth pursuit eye movements, indicating a cerebral dysfunction similar to those detected in schizophrenic patients. Moreover, normal smooth pursuit eye movement performance in DD patients was related to remitted depressive mood and probably to benefit from antipsychotic medications, thus supporting the idea of the biological and clinical heterogeneity of DD.
authors.affiliation: Psychiatric Branch, University of Milan Medical School, Italy. campana@uninetcom.it
authors.forename: A
authors.initials: A
authors.lastname: Campana
authors.forename: O
authors.initials: O
authors.lastname: Gambini
authors.forename: S
authors.initials: S
authors.lastname: Scarone
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D003702:Delusions / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012438:Saccades / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents