Arthralgias and cryoglobulinemia during protease inhibitor therapy in a patient infected with human immunodeficiency virus and hepatitis C virus.
We present the case of a woman who had a chronic infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). She developed severe polyarthralgias associated with type II mixed cryoglobulinemia during therapy with an HIV-1 protease inhibitor. This therapy resulted in a dramatic increase in her CD4+ T cell count, from 70/mm3 to 567/mm3, which was composed of a high proportion (88%) of naive CD45RA+ CD62L+ cells, together with a recovery of her CD4+ T cell reactivity to antigenic stimulation. This may suggest that rapid recovery of immune competence in the CD4+ T helper subset might participate in the development of immunopathologic events such as this patient's cryoglobulinemia.
Monsuez
J J
JJ
Hôpital Paul Brousse, Villejuif, France.
Vittecoq
D
D
Musset
L
L
Alemanni
M
M
Dussaix
E
E
Autran
B
B
D018771:Arthralgia / Q000139:chemically induced*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D003449:Cryoglobulinemia / Q000097:blood / Q000139:chemically induced*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy; D006801:Humans; D018655:Lymphocyte Count / Q000187:drug effects; D008875:Middle Aged
D017320:HIV Protease Inhibitors