Nitric oxide rather than superoxide or peroxynitrite inhibits insulin secretion and causes DNA damage in HIT-T15 cells.
Delaney
C A
CA
Biochemistry Group, School of Biological Sciences, University of Sussex Falmer, Brighton, United Kingdom.
Cunningham
J M
JM
Green
M H
MH
Green
I C
IC
D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D006224:Cricetinae; D005978:Glutathione / Q000031:analogs & derivatives* / Q000633:toxicity; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008647:Mesocricetus; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000633:toxicity; D009569:Nitric Oxide / Q000502:physiology*; D009603:Nitroso Compounds / Q000633:toxicity*; D026422:S-Nitrosoglutathione; D013482:Superoxide Dismutase / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism*
D007328:Insulin; D009603:Nitroso Compounds; D013481:Superoxides; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione; C002385:linsidomine; D008981:Molsidomine; D013482:Superoxide Dismutase; D005978:Glutathione