Association of elevated mutagenesis in the spleen with genetic susceptibility to induced plasmacytoma development in mice.
Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mice. This finding suggests a correlation between the genetic susceptibility to inflammation-induced peritoneal plasmacytomagenesis and the phenotype of increased mutagenesis in lymphoid tissues, raising the possibility that plasmacytoma resistance genes may inhibit tumor development by minimizing oxidative mutagenesis in B cells.
Felix
K
K
Laboratory of Genetics, DBS, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. felixk@dc37a.nci.nih.gov
Kelliher
K
K
Bornkamm
G W
GW
Janz
S
S
D000818:Animals; D019328:Buthionine Sulfoximine / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology; D004198:Disease Susceptibility; D005978:Glutathione / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D016296:Mutagenesis / Q000235:genetics*; D018384:Oxidative Stress / Q000235:genetics*; D010954:Plasmacytoma / Q000139:chemically induced / Q000235:genetics*; D013154:Spleen / Q000201:enzymology / Q000473:pathology*; D013729:Terpenes / Q000494:pharmacology
D002273:Carcinogens; D013729:Terpenes; C009042:pristane; D019328:Buthionine Sulfoximine; D005978:Glutathione