Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones.
C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.
Zhao
X
X
Public Health Research Institute, New York, New York 10016, USA.
Wang
J Y
JY
Xu
C
C
Dong
Y
Y
Zhou
J
J
Domagala
J
J
Drlica
K
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D027101:DNA Topoisomerase IV; D004250:DNA Topoisomerases, Type II / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology; D024841:Fluoroquinolones; D005798:Genes, Bacterial; D008826:Microbial Sensitivity Tests; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D011500:Protein Synthesis Inhibitors; D059005:Topoisomerase II Inhibitors; D002701:Chloramphenicol; D027101:DNA Topoisomerase IV; D004250:DNA Topoisomerases, Type II