title: Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG.
abstract: The protective potential of killed Leishmania major (ALM) along with BCG was evaluated against L. donovani in Indian langur monkeys in single and triple dose schedules. A delayed protection was observed in monkeys after a single dose schedule of ALM (3 mg)+BCG (3 mg) given intradermally 2 months before intravenous challenge with L. donovani. Triple dose schedule each of 1 mg ALM + 1 mg BCG was more effective. The status remained unchanged until the end of the experiment (approximately 8 months). The study indicates that a combination of ALM + BCG may be a good candidate vaccine for exploiting against human Kala-azar.
authors.affiliation: Division of Parasitology, Central Drug Research Institute, Lucknow, India. root@cscdri.ren.nic.in
authors.forename: A
authors.initials: A
authors.lastname: Dube
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: J K
authors.initials: JK
authors.lastname: Srivastava
authors.forename: A
authors.initials: A
authors.lastname: Misra
authors.forename: S
authors.initials: S
authors.lastname: Naik
authors.forename: J C
authors.initials: JC
authors.lastname: Katiyar
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D002520:Cercopithecidae / Q000276:immunology / Q000469:parasitology*; D006224:Cricetinae; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D007194:India; D007893:Leishmania donovani / Q000276:immunology*; D018320:Leishmania major / Q000276:immunology; D007898:Leishmaniasis, Visceral / Q000517:prevention & control*; D008297:Male; D016052:Protozoan Vaccines / Q000008:administration & dosage; D013154:Spleen / Q000469:parasitology; D014611:Vaccination / Q000379:methods*; D015164:Vaccines, Inactivated / Q000008:administration & dosage
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D016052:Protozoan Vaccines; D015164:Vaccines, Inactivated