title: Vanadyl treatment normalizes submandibular salivary gland insulin-like immunoreactivity in streptozotocin-diabetic rats.
abstract: Rat submandibular salivary glands (SSG) contain a compound displaying insulin-like immunoreactivity (ILI) and various biological activities of insulin. As SSG ILI levels were reported to be increased in streptozotocin (STZ)-induced diabetes but not normalized by a two-week insulin treatment, we decided to check whether another antidiabetic treatment, vanadyl sulphate (VOSO4), was able to regulate SSG ILI concentration. A short term (8 days) i.p. VOSO4 treatment (total dose = 1.3 mmol/kg) of rats made diabetic 8 days earlier by a single i.v. injection of STZ (60 mg/kg BW) was able to induce a long-term (4 weeks) correction of hyperglycemia while weight gain was re-established. In untreated diabetic animals (approximately -25%) and increased (approximately +175%) as compared to normal rats. Both parameters were normalized in VOSO4-treated diabetic rats.
authors.affiliation: Laboratoire de Physiologie, Faculté d'Odontologie, Montpellier, France.
authors.forename: D
authors.initials: D
authors.lastname: Deville de Périère
authors.forename: P
authors.initials: P
authors.lastname: Poucheret
authors.forename: J C
authors.initials: JC
authors.lastname: Egea
authors.forename: R
authors.initials: R
authors.lastname: Gross
authors.forename: P
authors.initials: P
authors.lastname: Masiello
authors.forename: G
authors.initials: G
authors.lastname: Cros
authors.forename: J J
authors.initials: JJ
authors.lastname: Serrano
authors.forename: G
authors.initials: G
authors.lastname: Ribes
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013363:Submandibular Gland / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism*; D017968:Vanadium Compounds / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D017968:Vanadium Compounds; C034028:vanadyl sulfate