New directions for neuronal migration.
Analysis of genetic mutations that lead to abnormal migration and layer formation in the developing cerebral cortex of mice and humans has led to important new discoveries regarding the molecular mechanisms that underlie these processes. Genetic manipulation and experimental analysis have demonstrated significant tangential migrations of cortical neurons, some arriving from very distant noncortical sites.
Pearlman
A L
AL
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA. apearl@cellbio.wustl.edu
Faust
P L
PL
Hatten
M E
ME
Brunstrom
J E
JE
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development; D005260:Female; D006801:Humans; D051379:Mice; D008818:Mice, Neurologic Mutants; D009474:Neurons / Q000502:physiology*; D010641:Phenotype; D011247:Pregnancy