title: Comparative experimental study of 10% and 15% medical gelatin in the anterior chamber and in the posterior eye segment as a viscosubstance in the viscosurgery.
abstract: This article discusses the possibility of application of 15% medical gelatin solution compared to 10% medical gelatin solution in the anterior chamber and in the posterior eye segment as a viscosubstance in the viscosurgery. The experimental investigations were performed on 24 Chinchilla rabbits, divided in two groups consisting of 12 each. 0.5 ml of 10% and 15% of medical gelatin were injected in the anterior chamber and 2 ml of 10% and 15% medical gelatin were injected in the vitreous body of the tested eyes. 2% methyl cellulose and 0.89% Sodium Chloride were injected in the vitreous body of the control eyes. Clinical, biomicroscopical, ophthalmoscopical, tonometrical, histological and electron-microscopical examinations were performed. It was established that when the eyes were injected with 10% and 15% medical gelatin, as well as with 0.89% Sodium Chloride, the intraocular pressure was not increased but when the eyes were injected with methyl cellulose the intraocular pressure was increased. We also found that 15% of medical gelatin has longer effect than 10% medical gelatin. Toxoallergic and inflammatory changes were not observed in the eyes injected with 10% and 15% medical gelatin. In the same eyes, histologically and by electron microscopy, were not found any changes in the layers of the cornea and retina. These substances could be used as viscosubstances and as instruments in surgical interventions of the anterior eye segment and in the posterior eye segment (vitrectomy).
authors.affiliation: Department of Ophthalmology, Medical Faculty, Sofia, Bulgaria.
authors.forename: K
authors.initials: K
authors.lastname: Krassimir
authors.forename: B
authors.initials: B
authors.lastname: Stefan
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects* / Q000601:surgery / Q000648:ultrastructure; D002682:Chinchilla; D003315:Cornea / Q000187:drug effects / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D005780:Gelatin / Q000008:administration & dosage / Q000633:toxicity*; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects; D009883:Ophthalmic Solutions; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000648:ultrastructure; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects* / Q000601:surgery / Q000648:ultrastructure
chemical_list: D009883:Ophthalmic Solutions; D005780:Gelatin