title: Transfusion management of an IgA deficient patient with anti-IgA and incidental correction of IgA deficiency after allogeneic bone marrow transplantation.
abstract: A patient with multiple myeloma was noted to have an IgA deficiency during investigation of a possible transfusion reaction due to IgA deficiency and anti-IgA. Because of the patient's age, otherwise good health, and early stage of disease, he was enrolled in a research treatment protocol that involved an allogeneic bone marrow transplant (BMT). The BMT successfully put the patient in complete remission from his multiple myeloma and corrected his IgA deficiency. Class-specific IgG anti-IgA antibody that had been identified prior to BMT was no longer detectable in his plasma. Anaphylactic transfusion reactions were successfully avoided by using a combination of IgA-deficient and washed blood components including the marrow graft, and IgA-reduced intravenous immunoglobulin.
authors.affiliation: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston 29425, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Rogers
authors.forename: T A
authors.initials: TA
authors.lastname: Javed
authors.forename: R E
authors.initials: RE
authors.lastname: Ross
authors.forename: G
authors.initials: G
authors.lastname: Virella
authors.forename: R K
authors.initials: RK
authors.lastname: Stuart
authors.forename: D
authors.initials: D
authors.lastname: Frei-Lahr
mesh_terms: D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000378:metabolism; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation / Q000276:immunology*; D006801:Humans; D017098:IgA Deficiency / Q000628:therapy*; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D009101:Multiple Myeloma / Q000628:therapy*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A