title: Successful treatment of a staphylococcal endocarditis vegetation with tissue plasminogen activator.
abstract: A 930 gm premature infant had Staphylococcal endocarditis with a tricuspid valvular vegetation that was unresponsive to antibiotics and not amenable to resection. Infusion of tissue plasminogen activator over a 3-day period completely lysed the vegetation. The infection cleared with continued antibiotics, and the infant recovered without sequelae.
authors.affiliation: Department of Pediatrics, St. Louis University School of Medicine, Missouri 63104, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Fleming
authors.forename: S J
authors.initials: SJ
authors.lastname: Barenkamp
authors.forename: S B
authors.initials: SB
authors.lastname: Jureidini
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010960:Plasminogen Activators / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator