title: The changes and significance of c-kit expression in the irradiated bone marrow of mice.
abstract: There have been only a few studies on the expression of c-kit in bone marrow after radiation and radiation-induced apoptosis of hematopoietic cells. LACA mice were examined after irradiation with a dose of 60Co gamma-rays. Using a light microscope, electron microscope, and immunohistochemistry, we studied radiation-induced apoptosis of hematopoietic cells and the expression of c-kit. We found that 5.5 Gy total body irradiation was a sublethal dose for LACA mice, induced suppression of leukocytes in blood, and of nucleated cells in bone marrow. Apoptosis of the hematopoietic cells occurred within 1 day after irradiation. The expression of c-kit was related to the recovery of hematopoiesis and played an important role in early hematopoiesis.
authors.forename: R
authors.initials: R
authors.lastname: Peng
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Xiong
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Cui
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Hu
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism* / Q000528:radiation effects*; D001855:Bone Marrow Diseases / Q000097:blood / Q000209:etiology* / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism / Q000528:radiation effects; D051379:Mice; D008815:Mice, Inbred Strains; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis*; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D014916:Whole-Body Irradiation
chemical_list: D019009:Proto-Oncogene Proteins c-kit