title: Prevalence of Helicobacter pylori infection in disorders of the upper gastrointestinal tract in south India.
abstract: BACKGROUND
  Helicobacter pylori (H. pylori) is the most common human infection. Though most individuals are asymptomatic, H. pylori plays a key role in the aetiology of many upper gastrointestinal disorders. The prevalence of duodenal ulcer in south India is high but there are very few reports regarding the prevalence of H. pylori infection in various upper gastrointestinal disorders in south Indians. Therefore, we studied the prevalence of H. pylori infection in upper gastrointestinal disorders in south Indians.
  
  
  METHODS
  Three hundred and thirty-five patients with various upper gastrointestinal disorders were included in the study. Seventy-five patients with no gastrointestinal disease based on symptoms and endoscopy were taken as controls. The H. pylori status was determined by the urease test, serology and histology and the prevalence compared between various upper gastrointestinal disorders, with controls and with one another.
  
  
  RESULTS
  The prevalence of H. pylori was high in the patients and controls. Duodenal ulcer patients had a significantly higher prevalence compared to controls (p < 0.001) and those with other upper alimentary disorders. There was no significant difference between patients with other disorders and controls nor between each other (p > 0.05).
  
  
  CONCLUSIONS
  The prevalence of H. pylori infection is high in south India. It is closely associated with duodenal ulcer. More population-based studies are required to evaluate the relationship of H. pylori with other disorders of the upper gastrointestinal tract.
authors.affiliation: Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
authors.forename: V
authors.initials: V
authors.lastname: Kate
authors.forename: N
authors.initials: N
authors.lastname: Ananthakrishnan
authors.forename: S
authors.initials: S
authors.lastname: Badrinath
authors.forename: C
authors.initials: C
authors.lastname: Ratnakar
mesh_terms: D005767:Gastrointestinal Diseases / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D007194:India / Q000453:epidemiology; D015995:Prevalence