title: The neuroanatomy and neurochemistry of schizophrenia.
abstract: Substantial progress, in part owing to recent refinements in methodology, has been made in unraveling the anatomic correlates of schizophrenia. Subtle pathomorphologic changes, distinct from those of well-known degenerative brain disorders, have been observed. Neurochemical characterization has illuminated the nature of these morphologic abnormalities and has pointed to complex dysregulation of neurotransmitters and G proteins. New biochemical hypotheses such as the glutamate hypothesis have replaced and revitalized more established concepts in the neurochemistry of schizophrenia.
authors.affiliation: NIMH Neuroscience Center at St. Elizabeths, Washington, DC 20032, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Weickert
authors.forename: J E
authors.initials: JE
authors.lastname: Kleinman
mesh_terms: D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008032:Limbic System / Q000378:metabolism / Q000473:pathology; D009434:Neural Pathways / Q000378:metabolism; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000378:metabolism / Q000473:pathology; D011877:Radionuclide Imaging; D017982:Receptors, Biogenic Amine / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology*; D013569:Synapses / Q000473:pathology
chemical_list: D017982:Receptors, Biogenic Amine; D018079:Receptors, GABA; D017470:Receptors, Glutamate