Possible role of GH/IGF-1 in the ovarian function of adult hypothyroid rats.
We have monitored estrous cycle and measured serum estradiol, GH, IGF-1, T4 and T3 levels in adult hypothyroid female rats which were divided into four groups: H group, hypothyroid rats without treatment; H-T4 group, hypothyroid rats injected daily with T4; HT4-PTU group, hypothyroid rats injected daily with T4 plus PTU (propylthiouracil), and H-T4-IOP group, hypothyroid rats injected daily with T4 plus IOP (iopanoic acid); Euthyroid rats (E group) were used as control. Our results indicate that the lack of sexual cycle in H animals was associated with lower values of estradiol, GH and IGF-1 in comparison to E group; the restoration of sexual cycle in H-T4 group was associated with values of estradiol, GH and IGF-1 higher than those of H group, whereas in H-T4-PTU and H-T-IOP groups the restoration was associated with higher values of GH and IGF-1 and values of estradiol similar to those of H group. These data could suggest a potential role of GH/IGF-1 axis, at least in part, in the lack of sexual cycle in H group and in the ovulation induction in H-T4, H-T4-PTU and H-T4-IOP groups.
Osorio
A
A
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Granada, Spain.
Ruiz
E
E
Ortega
E
E
D000818:Animals; D004958:Estradiol / Q000097:blood; D004971:Estrus / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000097:blood* / Q000502:physiology; D007037:Hypothyroidism / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism* / Q000502:physiology; D007480:Iopanoic Acid / Q000494:pharmacology; D010053:Ovary / Q000502:physiology*; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000502:physiology; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D011441:Propylthiouracil; D013006:Growth Hormone; D007480:Iopanoic Acid; D013974:Thyroxine