title: A cellular anti-apoptosis protein is cleaved by the HIV-1 protease.
abstract: Cleavage of non-viral proteins is rarely observed with the HIV-1 protease (HIV pr). One such cleavage event occurs with bcl-2, an important cytoprotective protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and programmed death of the host cell. A strategy is proposed to suppress HIV with non-cleavable mutants of bcl-2.
authors.affiliation: DuPont Merck Pharmaceutical Co., Experimental Station, Wilmington, Delaware 19880-0336, USA.
authors.forename: B D
authors.initials: BD
authors.lastname: Korant
authors.forename: P
authors.initials: P
authors.lastname: Strack
authors.forename: M W
authors.initials: MW
authors.lastname: Frey
authors.forename: C J
authors.initials: CJ
authors.lastname: Rizzo
mesh_terms: D017209:Apoptosis; D016333:HIV Protease / Q000378:metabolism*; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D016333:HIV Protease