Forward and reverse genetic approaches to synaptogenesis.
Genetic approaches at the neuromuscular synapse are leading investigation into the mechanisms of synaptogenesis. The marriage of classical (forward) and reverse genetic techniques allows the isolation and analysis of novel proteins involved in synaptic maturation and the functional in vivo characterization of previously identified synaptic proteins. Of particular interest are recent advances using mouse reverse genetics and Drosophila forward genetics.
Broadie
K
K
Department of Biology, University of Utah, Salt Lake City 84112-0840, USA. broadie@biology.utah.edu
D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development* / Q000502:physiology; D004330:Drosophila / Q000235:genetics; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure
D009419:Nerve Tissue Proteins