The neuroanatomy and neurochemistry of schizophrenia.
Substantial progress, in part owing to recent refinements in methodology, has been made in unraveling the anatomic correlates of schizophrenia. Subtle pathomorphologic changes, distinct from those of well-known degenerative brain disorders, have been observed. Neurochemical characterization has illuminated the nature of these morphologic abnormalities and has pointed to complex dysregulation of neurotransmitters and G proteins. New biochemical hypotheses such as the glutamate hypothesis have replaced and revitalized more established concepts in the neurochemistry of schizophrenia.
Weickert
C S
CS
NIMH Neuroscience Center at St. Elizabeths, Washington, DC 20032, USA.
Kleinman
J E
JE
D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008032:Limbic System / Q000378:metabolism / Q000473:pathology; D009434:Neural Pathways / Q000378:metabolism; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000378:metabolism / Q000473:pathology; D011877:Radionuclide Imaging; D017982:Receptors, Biogenic Amine / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology*; D013569:Synapses / Q000473:pathology
D017982:Receptors, Biogenic Amine; D018079:Receptors, GABA; D017470:Receptors, Glutamate