title: [Zidovudine-resistant HIV strains in untreated intravenous drug users and homosexual men in Amsterdam infected in 1996].
abstract: OBJECTIVE
  To gain insight into the spread of HIV strains with different sensitivities to antiretroviral drugs prescribed in the Netherlands.
  
  
  METHODS
  Prospective cohort study in intravenous drug users and homosexual men.
  
  
  METHODS
  Amsterdam, the Netherlands.
  
  
  METHODS
  HIV negative participants in the Amsterdam cohort studies among homosexual men and intravenous drug users are tested two to three times a year for HIV antibodies. The first positive serum sample of those who seroconverted was used to determine, on the basis of the nucleotide sequence of the reverse transcriptase gene of HIV, if viruses were present with a reduced sensitivity to reverse transcriptase inhibitors.
  
  
  RESULTS
  In 1996, 17 new HIV infections occurred (8 in homosexual men and 9 in intravenous drug users). In two new infections in homosexual men HIV strains with reduced sensitivity to zidovudine were present.
authors.affiliation: Academisch Medisch Centrum, afd. Humane Retrovirologie, Amsterdam.
authors.forename: J J
authors.initials: JJ
authors.lastname: de Jong
authors.forename: S
authors.initials: S
authors.lastname: Jurriaans
authors.forename: R A
authors.initials: RA
authors.lastname: Coutinho
authors.forename: F
authors.initials: F
authors.lastname: de Wolf
authors.forename: J
authors.initials: J
authors.lastname: Goudsmit
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000150:complications / Q000635:transmission / Q000821:virology*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D015819:Substance Abuse, Intravenous / Q000150:complications; D015215:Zidovudine / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D015215:Zidovudine