Topographic analysis of EEG photic driving in patients with schizophrenia following clozapine treatment.
Reduced EEG photic driving has been found to be diagnostically sensitive and specific for schizophrenia. Thirty-one patients with schizophrenia were tested in this study to identify the typical and atypical neuroleptic effects on the photic driving. Compared with the placebo, clozapine significantly enhanced the photically driven EEG in theta and low alpha frequency band, while haloperidol did not have the same effect. These changes with clozapine appeared to be symmetrical and located primarily in the frontal, central and mid-parietal areas but not in the lateral parietal, temporal and occipital regions. Results were consistent with previous findings and suggested that the atypical EEG profile of clozapine might be associated with 5-HT2 antagonistic property.
Jin
Y
Y
Department of Psychiatry and Human Behavior, College of Medicine, University of California Irvine, USA.
Potkin
S G
SG
Sandman
C A
CA
Bunney
W E
WE
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*
D014150:Antipsychotic Agents; D003024:Clozapine; D006220:Haloperidol