Inhibition of HIV-1 protease by water-soluble lignin-like substance from an edible mushroom, Fuscoporia obliqua.
Activity that inhibited protease of human immunodeficiency virus type 1 was found in boiling water extracts of an edible mushroom, Fuscoporia obliqua. The active component was identified as a water-soluble lignin derivative of high molecular weight. Other polyphenols of low molecular weight and monomeric components of lignin did not inhibit the protease.
Ichimura
T
T
National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology, Ibaraki, Japan.
Watanabe
O
O
Maruyama
S
S
D000595:Amino Acid Sequence; D001487:Basidiomycota / Q000737:chemistry*; D016333:HIV Protease / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008031:Lignin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D017320:HIV Protease Inhibitors; D008031:Lignin; D016333:HIV Protease