New insight into the topical management of excessive sebum flow at the skin surface.
The sebum flow dynamics at the skin surface results from a multistep process starting with sebocyte proliferation, intracellular lipid synthesis, cell lysis in the sebaceous duct, storage of sebum in the follicular reservoir, discharge through the follicular opening and spreading over the stratum corneum. A handful of topical products may decrease the sebum output, most of them acting at the level of the follicular reservoir function. Among them, elubiol exhibits a clinically relevant effect on oily skin.
Piérard
G E
GE
Belgian SSTC Research Unit 5596, Department of Dermatopathology, University of Liège, Belgium.
Ries
G
G
Cauwenbergh
G
G
D004148:Dioxolanes / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D012629:Sebum / Q000378:metabolism*; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D004148:Dioxolanes; D007093:Imidazoles