Effect of atenolol or metoprolol on waking hour dynamics of the QT interval in myocardial infarction.
In subjects with a recent acute myocardial infarction, the hour immediately following awakening is associated with an abrupt exaggeration of heart rate-dependent changes and variability of the QT interval. Beta blockers were observed to blunt these waking hour changes.
Singh
J P
JP
Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, United Kingdom.
Musialek
P
P
Sleight
P
P
Davey
P
P
Marinho
M
M
Hart
G
G
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001262:Atenolol / Q000627:therapeutic use*; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000187:drug effects; D015716:Electrocardiography, Ambulatory / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology*; D011446:Prospective Studies; D014851:Wakefulness / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D008790:Metoprolol