Olfactory deficits in patients with schizophrenia and severe polydipsia.
BACKGROUND
The present study was designed to assess olfactory function in severely polydipsic/hyponatremic patients with schizophrenia who also had intermittent water intoxication.


METHODS
The University of Pennsylvania Smell Identification Test and an olfactory acuity battery were administered to three groups of male subjects: 9 patients with schizophrenia and severe polydipsia/hyponatremia, 9 control nonpolydipsic/normonatremic patients with schizophrenia, and 9 normal controls.


RESULTS
Male patients with severe polydipsia/hyponatremia and intermittent water intoxication had marked olfactory acuity and identification deficits when compared to the patient control group of similar age and age at illness onset, and to normal controls.


CONCLUSIONS
The finding of deficient acuity (detection threshold) in the polydipsic/hyponatremic group but not the nonpolydipsic, normonatremic group suggests that for this subgroup, abnormalities of olfactory sensory function may occur in a pattern previously reported for other brain disorders such as Alzheimer's disease.
Kopala
L C
LC
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Good
K P
KP
Koczapski
A B
AB
Honer
W G
WG
D020001:1-Butanol; D000328:Adult; D004327:Drinking Behavior; D006801:Humans; D007010:Hyponatremia / Q000209:etiology; D008297:Male; D009483:Neuropsychological Tests; D000857:Olfaction Disorders / Q000150:complications*; D011569:Psychiatric Status Rating Scales; D012565:Schizophrenic Psychology
D020001:1-Butanol