title: DNA topoisomerase I inhibitors.
authors.affiliation: Navy Medical Oncology Branch, National Cancer Institute, Naval Hospital Bethesda, MD 20889-5105, USA.
authors.forename: C H
authors.initials: CH
authors.lastname: Takimoto
authors.forename: L V
authors.initials: LV
authors.lastname: Kieffer
authors.forename: S G
authors.initials: SG
authors.lastname: Arbuck
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000494:pharmacology; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D004249:DNA Damage; D004264:DNA Topoisomerases, Type I / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D000077146:Irinotecan; D009369:Neoplasms / Q000188:drug therapy; D059004:Topoisomerase I Inhibitors; D019772:Topotecan / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors; C080125:9-aminocamptothecin; D000077146:Irinotecan; D019772:Topotecan; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin