title: Blood degradation products play a role in cerebral ischemia caused by acute subdural hematoma.
abstract: The pathogenesis of ischemic brain lesions with traumatic hematoma is multifactorial. It has been suggested that the presence of subdural hematoma in patients with severe head injury is associated with elevated intracranial pressure and higher mortality. In this study we created acute subdural mass in the rats by injecting 250 microliters of autologous blood and silicone oil into the subdural space. The goal of this study was to determine the effect of subdural hematoma versus silicone oil on the adjacent brain parenchyma. Twenty-four hours after the injection, of the hematoma in the subdural space in rats produced an extensive zone of underlying ischemic damage but silicone oil did not. This study has shown that pressure alone caused by silicone oil is insufficient to cause significant neuronal damage or loss.
authors.affiliation: Department of Neurosurgery, Istanbul University Cerrahpasa Medical Faculty, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yilmazlar
authors.forename: M
authors.initials: M
authors.lastname: Hanci
authors.forename: B
authors.initials: B
authors.lastname: Oz
authors.forename: C
authors.initials: C
authors.lastname: Kuday
mesh_terms: D000818:Animals; D001804:Blood Transfusion, Autologous / Q000009:adverse effects*; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D003643:Death; D005260:Female; D006408:Hematoma, Subdural / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D007427:Intracranial Pressure; D009043:Motor Activity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012828:Silicones
chemical_list: D012828:Silicones