Combination of LC-MS and LC-NMR as a Tool for the Structure Determination of Natural Products
Application of both LC-MS and LC-NMR to a partially purified extract of Vernonia fastigiataled to the direct identification of antibacterial sesquiterpene lactones 1-9 without isolation of individual compounds. The rapid structural analysis of both major and minor components of this class of compounds demonstrated the power of structure-guided screening as a complementary method to assay-guided screening.
Vogler
B
Department of Chemistry, University of Hohenheim, D-70593 Stuttgart, Germany, and Varian GmbH, D-64289 Darmstadt, Germany.
Klaiber
I
Roos
G
Walter
CU
Hiller
W
Sandor
P
Kraus
W