title: [Plasma TGF-beta1 concentrations in patients with prostate carcinoma or benign prostatic hyperplasia].
abstract: Transforming growth factor-beta 1 (TGF-beta 1) is a pleiotrophic growth factor in carcinogenesis and regulars multiple cell functions. We wanted to evaluate the diagnostic meaning of TGF-beta 1 plasma levels in patients with a biopsy proven prostate cancer. The TGF-beta 1 blood level was analysed in 394 patients. In 242 patients (group I) the blood was taken before any prostate manipulation and biopsy. The TGF-beta 1 plasma concentrations were almost similar in the group of patients with a prostate cancer (n = 157) and patients with a benign prostate hyperplasia (n = 85; 14,258 pg/ml versus 14,658 pg/ml, SD 10,516 pg/ml). In 152 patients the blood was taken 6-12 months after radical prostatectomy (group II). There was no significant difference between the patients with a PSA-progress and without PSA-progress after. Our results suggest that TGF-beta 1 plasma levels can not be used to distinguish between patients with prostate cancer and benign prostate hyperplasia.
authors.affiliation: Urologische Klinik, Universitätskrankenhaus Eppendorf, Hamburg.
authors.forename: I
authors.initials: I
authors.lastname: Lange
authors.forename: P
authors.initials: P
authors.lastname: Hammerer
authors.forename: C
authors.initials: C
authors.lastname: Knabbe
authors.forename: M
authors.initials: M
authors.lastname: Graefen
authors.forename: M
authors.initials: M
authors.lastname: Schmahl
authors.forename: H
authors.initials: H
authors.lastname: Huland
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood / Q000175:diagnosis*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis*; D016212:Transforming Growth Factor beta / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D016212:Transforming Growth Factor beta; D017430:Prostate-Specific Antigen