[The effect of two beta-2 sympathomimetic bronchospasmolytics on the ratio of sialylated and sulfated glycoconjugates in goblet cell secretions of the tracheal epithelium].
Rabbits were made to inhale two different beta 2 sympathomimetic bronchospasmolytics-salbutamol in Ventolin and phenoterolhydrobromid in Berotec. Changes of secretion contents in tracheal goblet cells were evaluated by classical and lectin histochemistry 30 minutes after administration of drugs. When comparing with control rabbits Ventolin completely suppressed the secretion of neutral glycoconjugates for the benefit of acidic glycoconjugates and completely suppressed sialylation. The administration of Berotec suppressed neutral glycoconjugates, either, but the suppression of sialylation was uncomplete. Berotec was found a less damaging agent.
Vajner
L
L
Ustav histologie a embryologie 2. LF UK, Praha.
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005280:Fenoterol / Q000494:pharmacology*; D006001:Glycoconjugates / Q000378:metabolism*; D011817:Rabbits; D013566:Sympathomimetics / Q000494:pharmacology*; D014132:Trachea / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D001993:Bronchodilator Agents; D006001:Glycoconjugates; D013566:Sympathomimetics; D005280:Fenoterol; D000420:Albuterol