New imidazole alkaloids and zinc complexes from the micronesian sponge Leucetta cf. chagosensis.
Four new imidazole alkaloids, 2-5, along with the known isonaamidine B (1) were isolated from a Pacific sponge, Leucetta cf. chagosensis, collected from Yap, Federated States of Micronesia. Among these, 4 and 5 are zinc complexes derived from isonaamidine B and isonaamidine D. The structures of the new compounds were elucidated from spectral data. Isonaamidine D (3) showed weakly antifungal activity against Aspergillus niger with MIC = 100 micrograms/mL.
Fu
X
X
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
Schmitz
F J
FJ
Tanner
R S
RS
Kelly-Borges
M
M
D000470:Alkaloids / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D007093:Imidazoles / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008849:Micronesia; D008969:Molecular Sequence Data; D011161:Porifera / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007093:Imidazoles