title: Antiinflammatory and antipyretic activity of Michelia champaca Linn., (white variety), Ixora brachiata Roxb. and Rhynchosia cana (Willd.) D.C. flower extract.
abstract: Methanolic extracts of the flowers of M. champaca, I. Brachiata and R. cana were found to possess antiinflammatory activity against cotton pellet granuloma in rats at a dose level of 100 mg/kg body weight, sc. The latter two drugs showed higher activity (AIA) as compared to that of M. champaca. They reduced the protein content, acid phosphatase, glutamate pyruvate transaminase and glutamate oxalo-acetate transaminase activities in liver and serum. A significant reduction in the ascorbic acid content in adrenals was also observed in drug-treated animals. R. cana was recorded to possess significant antipyretic activity from the first hour of administration. These pharmacological properties may be traced to the presence of flavonoids in the flowers of these plants.
authors.affiliation: Department of Chemistry, Bharathidasan University, Tiruchirappalli, India.
authors.forename: R
authors.initials: R
authors.lastname: Vimala
authors.forename: S
authors.initials: S
authors.lastname: Nagarajan
authors.forename: M
authors.initials: M
authors.lastname: Alam
authors.forename: T
authors.initials: T
authors.lastname: Susan
authors.forename: S
authors.initials: S
authors.lastname: Joy
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005419:Flavonoids / Q000302:isolation & purification / Q000627:therapeutic use; D006099:Granuloma / Q000188:drug therapy; D007194:India; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D010936:Plant Extracts