title: Exploring development and disease through germ-line genetic engineering in the mouse.
abstract: New developments in mouse genetics have transformed the field of genetics from a reactive to a proactive science. Current technologies in transgenesis, chromosome engineering, and saturation mutagenesis are introduced. These approaches permit the creation of new mutations and consequent mutant phenotypes that facilitate both the understanding of functions of existing genes and the search for previously unidentified genes affecting important phenotypes in all mammals.
authors.affiliation: Department of Physiology, Johns Hopkins University School of Medicine in Baltimore, MD, USA. rreeves@welchlink.welch.jhu.edu
authors.forename: R H
authors.initials: RH
authors.lastname: Reeves
mesh_terms: D000818:Animals; D015509:Developmental Biology / Q000379:methods*; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005818:Genetic Engineering; D018095:Germ-Line Mutation; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*