Acute glucosuria after continuous glucocorticoid loading in the rat in vivo.
We investigated the effects of the continuous infusion of various steroids in rats on renal tubular reabsorption of glucose in vivo to elucidate the pathogenesis of steroid-induced glucosuria. Urinary glucose excretion increased 60 min after administration of dexamethasone (2.38 mM). By 120 min, urinary excretion of glucose was three times higher in the dexamethasone group than in the control group (24.1 +/- 4.6 versus 72.4 +/- 16.7 micromol); the plasma level of glucose did not increase. Dexamethasone had no effect on the resorption of 1,5-anhydro-D-glucitol, which is a glucose-resembling polyol that is actively absorbed by the renal tubules as glucose. Neither estradiol nor progesterone increased urinary excretion of glucose. These findings suggest that continuous administration of a high-dose glucocorticoid selectively influences the glucose reabsorption system in the kidney.
Yamanouchi
T
T
Second Department of Internal Medicine, University of Teikyo, Tokyo, Japan.
Sekino
N
N
Yoshimura
T
T
Kawasaki
T
T
Koshibu
E
E
Inoue
T
T
Funato
H
H
Ogata
N
N
Miyashita
H
H
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003847:Deoxyglucose / Q000378:metabolism; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006029:Glycosuria / Q000139:chemically induced* / Q000378:metabolism; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood; D008297:Male; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D005938:Glucocorticoids; D007328:Insulin; D011374:Progesterone; D004958:Estradiol; C006584:1,5-anhydroglucitol; D003907:Dexamethasone; D003847:Deoxyglucose