Platelet MAO-B activity and serotonin content in patients with dementia: effect of age, medication, and disease.
This study aimed at determining the effect of drug therapy, age and type of dementia on biological markers. Both platelet monoamine oxidase type B (MAO-B) activity and serotonin content of 57 demented patients and 20 control subjects were determined. Platelet MAO-B activity was measured using [14C]tyramine as substrate. Serotonin content was determined by HPLC-EC method. Increased platelet serotonin content and platelet count was found in patients with dementia compared to controls. A positive correlation was experienced between platelet MAO-B activity, platelet serotonin content and age. Platelet MAO-B activity was higher in the haloperidol treated group, compared with patients treated with anxyolitics. The main original finding of the present study is that platelet serotonin content is increased in demented patients with delusions compared to dementia without complications (p = 0.006). It seems, that platelet MAO-B activity is influenced mainly by drug therapy, while serotonin content rather reflects clinical characteristics in dementia.
Mészáros
Z
Z
Department of Pharmacodynamics, Semmelweis University of Medicine, Budapest, Hungary. meszzsu@net.sote.hu
Borcsiczky
D
D
Máté
M
M
Tarcali
J
J
Szombathy
T
T
Tekes
K
K
Magyar
K
K
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000097:blood / Q000150:complications / Q000188:drug therapy; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism*; D003702:Delusions / Q000097:blood / Q000150:complications / Q000188:drug therapy; D003704:Dementia / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010300:Parkinson Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy; D010976:Platelet Count; D012701:Serotonin / Q000097:blood*; D012737:Sex Factors
D014150:Antipsychotic Agents; D015415:Biomarkers; D012701:Serotonin; D008995:Monoamine Oxidase