title: Partial liquid ventilation improves gas exchange and increases EELV in acute lung injury.
abstract: Gas exchange is improved during partial liquid ventilation with perfluorocarbon in animal models of acute lung injury. The specific mechanisms are unproved. We measured end-expiratory lung volume (EELV) by null-point body plethysmography in anesthetized sheep. Measurements of gas exchange and EELV were made before and after acute lung injury was induced with intravenous oleic acid to decrease EELV and worsen gas exchange. Measurements of gas exchange and EELV were again performed after partial liquid ventilation with 30 ml/kg of perfluorocarbon and compared with gas-ventilated controls. Oxygenation was significantly improved during partial liquid ventilation, and EELV (composite of gas and liquid) was significantly increased, compared with preliquid ventilation values and gas-ventilated controls. We conclude that partial liquid ventilation may directly recruit consolidated alveoli in the lung-injured sheep and that this may be one mechanism whereby gas exchange is improved.
authors.affiliation: Department of Surgery, University of Michigan Medical School, Ann Arbor 48109, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Gauger
authors.forename: M C
authors.initials: MC
authors.lastname: Overbeck
authors.forename: S D
authors.initials: SD
authors.lastname: Chambers
authors.forename: C I
authors.initials: CI
authors.lastname: Cailipan
authors.forename: R B
authors.initials: RB
authors.lastname: Hirschl
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D005466:Fluorocarbons / Q000378:metabolism*; D008168:Lung / Q000473:pathology; D008176:Lung Volume Measurements; D019301:Oleic Acid / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D010991:Plethysmography / Q000295:instrumentation / Q000379:methods; D011650:Pulmonary Alveoli / Q000502:physiology; D012123:Pulmonary Ventilation / Q000502:physiology*; D012119:Respiration / Q000502:physiology; D012131:Respiratory Insufficiency / Q000503:physiopathology; D012756:Sheep
chemical_list: D005466:Fluorocarbons; D002245:Carbon Dioxide; D019301:Oleic Acid; D010100:Oxygen