title: Mechanisms and clinical significance of cell volume regulation.
abstract: A wide variety of factors challenge constancy of cell volume. Alterations of cell volume activate diverse cell volume regulatory mechanisms including ion transport, osmolyte accumulation, metabolism and expression of appropriate genes. A wealth of cellular signalling pathways link cell volume to the respective regulatory mechanisms. Cell volume emerges as a pathophysiologically important parameter in several diseases including diabetes mellitus, uraemia, hepatic insufficiency and hypercatabolic states. The role of altered cell volume in disease is a challenge which requires more experimental research and clinical investigation.
authors.affiliation: Department of Physiology, University of Tübingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Waldegger
authors.forename: S
authors.initials: S
authors.lastname: Steuer
authors.forename: T
authors.initials: T
authors.lastname: Risler
authors.forename: A
authors.initials: A
authors.lastname: Heidland
authors.forename: G
authors.initials: G
authors.lastname: Capasso
authors.forename: S
authors.initials: S
authors.lastname: Massry
authors.forename: F
authors.initials: F
authors.lastname: Lang
mesh_terms: D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D048429:Cell Size; D006801:Humans; D017136:Ion Transport; D007674:Kidney Diseases / Q000473:pathology*; D015398:Signal Transduction