Genotoxicity of polycyclic musk fragrances in the sister-chromatid exchange test.
The synthetic polycyclic musk fragrance compounds Galaxolide (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclo-penta-(g)-2-++ +benzopyrane, Tonalide (7-acetyl-1,1,3,4,4,6-hexamerthyltetraline), Celestolide (4-acetyl-1,1-dimethyl-6-tert, butylindane), Phantolide (6-acetyl-1,1,2,3,3,5-hexamethylindane), Cashmeran (6,7-dihydro-1,1,2,3,3-pentamethyl-4-(5H) indanone) and Traseolide (5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane) are widely used as fragrance ingredients in perfumes, lotions and detergents; as food additives in cigarettes and fish baits. Several studies identified polycyclic musk fragrances in aquatic environment samples, human milk and human adipose tissue as highly lipophil with human lymphocytes.
Kevekordes
S
S
Medical Institute of General Hygiene and Environmental Health, University of Göttingen, Germany. skeveko@gwdg.de
Mersch-Sundermann
V
V
Diez
M
M
Bolten
C
C
Dunkelberg
H
H
D000328:Adult; D001578:Benzopyrans / Q000494:pharmacology; D002478:Cells, Cultured; D004249:DNA Damage / Q000187:drug effects; D005229:Fatty Acids, Monounsaturated; D006801:Humans; D007189:Indans / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D010476:Perfume / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
C110695:5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane; D001578:Benzopyrans; D005229:Fatty Acids, Monounsaturated; D007189:Indans; D010476:Perfume; D013764:Tetrahydronaphthalenes; C008563:musk; C033118:acetyl tert-butyl dimethylindan; C033119:galaxolide; C033117:phantolid; C033116:acetyl methyl tetramethyl tetralin; C110694:6,7-dihydro-1,1,2,3,3-pentamethyl-4-(5H)indanone