title: High performance liquid chromatographic determination of mercapturic acids in urine of rats administered with m- or p-xylene.
abstract: The determination of urinary mercapturic acid, N-acetyl-S-(m-xylyl)-L-cysteine or N-acetyl-S-(p-xylyl)-L-cysteine, was undertaken by HPLC after i.p. administration of m- or p-xylene to rats in order to confirm the structure of thioether which was known to be excreted in small amounts related with the metabolism of m- or p-xylene. The excretion rates of these mercapturic acids were much lower than those previously estimated from thioether determinations. The present study clearly demonstrates the mercapturic acid pathway operates only to limited degree as a metabolic route of m- or p-xylene.
authors.affiliation: Osaka City Institute of Public Health and Environmental Sciences, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tsujimoto
authors.forename: T
authors.initials: T
authors.lastname: Noda
authors.forename: H
authors.initials: H
authors.lastname: Moriwaki
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000111:Acetylcysteine / Q000652:urine*; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides / Q000652:urine; D014992:Xylenes / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D013440:Sulfides; D014992:Xylenes; C031286:4-xylene; C031285:3-xylene; D000111:Acetylcysteine