Reduced long-term respiratory morbidity after treatment of respiratory syncytial virus bronchiolitis with ribavirin in previously healthy infants: a preliminary report.
Previously healthy infants less than 6 months of age with severe respiratory syncytial virus bronchiolitis who required hospitalization were identified from hospital records. Infants had been treated either conservatively (control group, n = 19) or with ribavirin added to conservative management (study group, n = 22). All infants underwent a 1-year follow-up after the initial illness. There was a significant reduction in the prevalence of reactive airway disease in the group treated with ribavirin (P < 0.05) compared with the control group, both in terms of the proportion of patients developing airway reactivity (59% vs. 89%) and the number of episodes of reactive airway disease (31 vs. 70). Our data suggest that ribavirin reduces the prevalence of airway reactivity.
Edell
D
D
West Jefferson Medical Center, Marrero, Louisiana 70072, USA.
Bruce
E
E
Hale
K
K
Edell
D
D
Khoshoo
V
V
D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D001249:Asthma / Q000517:prevention & control; D016535:Bronchial Hyperreactivity / Q000517:prevention & control*; D001988:Bronchiolitis / Q000188:drug therapy / Q000821:virology*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D010102:Oxygen Inhalation Therapy; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D015995:Prevalence; D012135:Respiratory Sounds / Q000187:drug effects; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy*; D018113:Respiratory Syncytial Virus, Human; D012189:Retrospective Studies; D012254:Ribavirin / Q000627:therapeutic use*
D000998:Antiviral Agents; D001993:Bronchodilator Agents; D005938:Glucocorticoids; D012254:Ribavirin; D000420:Albuterol; D011241:Prednisone; D008775:Methylprednisolone