Anti-Hu-associated paraneoplastic sensory neuropathy with peripheral nerve demyelination and microvasculitis.
A patient had a paraneoplastic autonomic, then sensory, then sensory-motor neuropathy with small cell lung carcinoma and a high titer Anti-Hu antibody to nuclei of neuronal cells. As an unusual finding there was electrophysiological and pathological evidence of demyelination and a peripheral nerve microvasculitis. The relationship of microvasculitis and peripheral nerve demyelination is discussed and their occurrence with paraneoplastic anti-Hu-associated sensory neuropathy is suggested not to be by chance.
Eggers
C
C
Department of Neurology, University Hospital of Hamburg, Germany.
Hagel
C
C
Pfeiffer
G
G
D000368:Aged; D000906:Antibodies / Q000276:immunology*; D001706:Biopsy; D018288:Carcinoma, Small Cell / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D051959:ELAV Proteins; D004576:Electromyography; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009419:Nerve Tissue Proteins; D009431:Neural Conduction / Q000502:physiology; D010257:Paraneoplastic Syndromes / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D016601:RNA-Binding Proteins / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology
D000906:Antibodies; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins