Inhibitory processes in covert orienting in patients with Alzheimer's disease.
Previous studies of covert orienting in Alzheimer's disease (AD) have investigated exogenous and endogenous processes separately. We aimed to investigate how the 2 modes of orienting interact to control attention in healthy older participants and patients with AD. The covert orienting of visual attention task (COVAT) with abrupt onset cues was used in all experiments. In Experiments 1 and 2, predictive information was added to cues to initiate an endogenous orienting response. Results showed that healthy older participants were able to use endogenous processes to inhibit exogenous orienting. In contrast, patients with AD were unable to inhibit exogenous orienting to cues even when targets rarely appeared there. Experiment 3 investigated inhibition of return (IOR) in patients with AD. Both healthy older controls and patients with AD showed a normal IOR, suggesting that exogenous orienting processes are relatively unaffected by the normal aging process or in patients with AD. A model of covert orienting in which exogenous and endogenous orienting processes interact to control attentional behaviors is discussed.
Danckert
J
J
Neurophysiology and Neurovisual Research Unit, Mental Health Research Institute of Victoria, Parkville, Australia. james@neuro.mhri.edu.au
Maruff
P
P
Crowe
S
S
Currie
J
J
D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D016022:Case-Control Studies; D003463:Cues; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D009949:Orientation / Q000502:physiology*; D010468:Perceptual Disorders / Q000503:physiopathology*; D011930:Reaction Time; D013028:Space Perception / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*; D014836:Volition / Q000502:physiology