title: Stroke in a neonate heterozygous for factor V Leiden.
abstract: Activated protein C resistance is the most common hereditary coagulation abnormality and is caused by the factor V Leiden mutation. A newborn who developed seizures within hours after delivery and was found to have a bihemispheric stroke is described. This patient, determined to be heterozygous for factor V Leiden, is the first reported case of neonatal stroke associated with this common mutation.
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
authors.forename: P N
authors.initials: PN
authors.lastname: Varelas
authors.forename: B J
authors.initials: BJ
authors.lastname: Sleight
authors.forename: H M
authors.initials: HM
authors.lastname: Rinder
authors.forename: G
authors.initials: G
authors.lastname: Sze
authors.forename: L R
authors.initials: LR
authors.lastname: Ment
mesh_terms: D002561:Cerebrovascular Disorders / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D014057:Tomography, X-Ray Computed
chemical_list: C095381:factor V Leiden; D005165:Factor V