title: Chondroblastic osteosarcoma: characterisation by gadolinium-enhanced MR imaging correlated with histopathology.
abstract: OBJECTIVE
  To identify specific features of chondroblastic osteosarcoma on gadopentetate dimeglumine (Gd)-enhanced magnetic resonance (MR) imaging.
  
  
  METHODS
  Nine patients with chondroblastic osteosarcoma and a control group of 20 patients with conventional central osteosarcoma were included in this study. The histopathological findings of the surgical specimens were compared with enhancement patterns on static Gd-enhanced MR images.
  
  
  RESULTS
  In chondroblastic osteosarcoma septonodular and peripheral rim enhancement represented tumour with a pure chondroid matrix. Non-enhancing and heterogeneous enhancing areas represented tumour with both chondroid and osteoid matrix. In the tumours in the control group enhancement was predominantly heterogeneous but in one it was homogeneous. All these areas corresponded to necrotic or viable osteoid tumour tissue or fibrovascular tissue in areas of necrosis.
  
  
  CONCLUSIONS
  Gd-enhanced MR imaging can assist in obtaining diagnostic biopsy material of chondroblastic osteosarcoma by identifying both osteoid- and chondroid-forming areas.
authors.affiliation: Department of Radiology, Leiden University Medical Center, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Geirnaerdt
authors.forename: J L
authors.initials: JL
authors.lastname: Bloem
authors.forename: H J
authors.initials: HJ
authors.lastname: van der Woude
authors.forename: A H
authors.initials: AH
authors.lastname: Taminiau
authors.forename: M A
authors.initials: MA
authors.lastname: Nooy
authors.forename: P C
authors.initials: PC
authors.lastname: Hogendoorn
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D016022:Case-Control Studies; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012516:Osteosarcoma / Q000175:diagnosis* / Q000473:pathology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA