Early-onset phenytoin toxicity mimicking a renopulmonary syndrome.
Phenytoin is a commonly used anti-epileptic drug. Adverse reactions including fever, skin reactions and lymphadenopathy are well known but atypical reactions can also occur. A patient is described with a lag time of only 4 days between onset of phenytoin and the development of a syndrome with acute lung injury and renal failure. The symptoms mimicked a renopulmonary syndrome, and resolved completely after cessation of phenytoin and addition of steroids.
Polman
A J
AJ
Dept of Internal Medicine, University Hospital Groningen, The Netherlands.
van der Werf
T S
TS
Tiebosch
A T
AT
Zijlstra
J G
JG
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000175:diagnosis*; D000328:Adult; D000927:Anticonvulsants / Q000506:poisoning*; D001980:Bronchi / Q000473:pathology; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced / Q000175:diagnosis*; D008297:Male; D010672:Phenytoin / Q000506:poisoning*; D011239:Prednisolone / Q000627:therapeutic use; D013902:Radiography, Thoracic; D012640:Seizures / Q000188:drug therapy; D013997:Time Factors
D000927:Anticonvulsants; D005938:Glucocorticoids; D010672:Phenytoin; D011239:Prednisolone