The changes and significance of c-kit expression in the irradiated bone marrow of mice.
There have been only a few studies on the expression of c-kit in bone marrow after radiation and radiation-induced apoptosis of hematopoietic cells. LACA mice were examined after irradiation with a dose of 60Co gamma-rays. Using a light microscope, electron microscope, and immunohistochemistry, we studied radiation-induced apoptosis of hematopoietic cells and the expression of c-kit. We found that 5.5 Gy total body irradiation was a sublethal dose for LACA mice, induced suppression of leukocytes in blood, and of nucleated cells in bone marrow. Apoptosis of the hematopoietic cells occurred within 1 day after irradiation. The expression of c-kit was related to the recovery of hematopoiesis and played an important role in early hematopoiesis.
Peng
R
R
Wang
D
D
Xiong
C
C
Li
Y
Y
Gao
Y
Y
Wang
B
B
Cui
Y
Y
Yang
H
H
Hu
W
W
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism* / Q000528:radiation effects*; D001855:Bone Marrow Diseases / Q000097:blood / Q000209:etiology* / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism / Q000528:radiation effects; D051379:Mice; D008815:Mice, Inbred Strains; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis*; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D014916:Whole-Body Irradiation
D019009:Proto-Oncogene Proteins c-kit