title: Delayed MR imaging of the liver: correlation of delayed enhancement of hepatic tumors and pathologic appearance.
abstract: BACKGROUND
  The value of delayed magnetic resonance (MR) imaging (6 min) and ultradelayed MR imaging (1-4 h) for differentiating of hepatic tumors was studied.
  
  
  METHODS
  Postcontrast delayed and ultradelayed MR images were obtained after administration of 0.1 mmol/kg of Gd-DTPA in 30 patients with various malignant hepatic tumors.
  
  
  RESULTS
  Delayed enhancement in the center of the tumors was seen in 13 patients on the delayed MR images and in 22 patients on the ultradelayed MR images. On the ultradelayed images, peripheral hypointense rim was seen in 12 patients and central focal hypointense area was seen in eight patients. Pathologically, the portion showing delayed enhancement corresponded to abundant fibrous stroma, the hypointense rim to rich proliferation of tumor cells, and the central hypointense areas to coagulative necrosis.
  
  
  CONCLUSIONS
  Ultradelayed MR imaging can characterize different tissue components within various hepatic tumors.
authors.affiliation: Department of Radiology, Kanazawa University, School of Medicine, Kanazawa City, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Gabata
authors.forename: O
authors.initials: O
authors.lastname: Matsui
authors.forename: M
authors.initials: M
authors.lastname: Kadoya
authors.forename: J
authors.initials: J
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamori
authors.forename: T
authors.initials: T
authors.lastname: Takashima
authors.forename: A
authors.initials: A
authors.lastname: Nonomura
mesh_terms: D000368:Aged; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000601:surgery; D002455:Cell Division; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000601:surgery; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis; D013997:Time Factors
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA