[Successful syngeneic peripheral blood stem cell transplantation for protracted myelosuppression after chemotherapy in a patient with acute myelogenous leukemia].
Acute myelogenous leukemia (M2) with translocation of 8;21. Was diagnosed in 61-year-old man. He was successfully treated and obtained complete remission. After consolidation therapy, myeloid suppression and maturation arrest at the myelocyte level were recognized. Following intensive chemotherapy, he received rhG-CSF-mobilized peripheral blood stem cell transplantation (PBSCT) from an identical twin because he had life threatening infectious events and protracted myelosuppression. Transplantation of 2.5 x 10(6)/kg CD34+ cells resulted in a rapid normal tri-lineage hematologic reconstitution. Syngeneic PBSCT appears to be a substitute for syngeneic bone marrow transplantation in certain situations.
Morita
K
K
Internal Medicine, Suzuka Kaisei General Hospital.
Mizuno
T
T
Itoh
R
R
Suzuki
H
H
Tanaka
I
I
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000187:drug effects*; D003131:Combined Modality Therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D008875:Middle Aged