Biosynthetic studies on the alpha-glucosidase inhibitor acarbose in Actinoplanes sp.: glutamate is the primary source of the nitrogen in acarbose.
Lee
S
S
Department of Chemistry, University of Washington, Seattle 98195-1700, USA.
Egelkrout
E
E
D020909:Acarbose; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D018698:Glutamic Acid / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism; D014312:Trisaccharides / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification
D004791:Enzyme Inhibitors; D014312:Trisaccharides; D018698:Glutamic Acid; D005959:Glucosidases; D009584:Nitrogen; D020909:Acarbose