Mos and the cell cycle.
The mos proto-oncogene-encoded serine/threonine protein kinase plays a key cell cycle-regulatory role during meiosis. The Mos protein is required for the activation and stabilisation of M phase-promoting factor MPF. As a component of a large multiprotein complex known as the cytostatic factor (CSF), Mos is involved in causing metaphase II arrest of eggs in vertebrates. Upon expression in somatic cells, Mos causes cell cycle perturbations resulting in cytotoxicity and neoplastic transformation. All the known biological activities of Mos are mediated through activation of the mitogen activated protein (MAP) kinase pathway. Here we discuss the interrelationship between Mos and other cell cycle regulators.
Singh
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Department of Molecular Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Arlinghaus
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D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology*; D005260:Female; D006801:Humans; D016200:Maturation-Promoting Factor / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology; D009865:Oocytes / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D010766:Phosphorylation; D000090063:Proto-Oncogene Mas; D017231:Proto-Oncogene Proteins c-mos / Q000737:chemistry / Q000502:physiology*; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism; D015398:Signal Transduction
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D017231:Proto-Oncogene Proteins c-mos; D019908:Proto-Oncogene Proteins c-raf; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D016200:Maturation-Promoting Factor