title: Solitary fibrous tumor of the meninges.
abstract: The clinical, radiologic, and pathologic features of a case of solitary fibrous tumor of the meninges at the base of the brain are reported. The tumor caused clinical symptoms in a 42-year-old Caucasian male which were indicative of compression of hypothalamus, basal ganglia, and third ventricle. Radiologically it was a large extra-axial mass isointense to brain parenchyma on precontrast T1-weighted images that filled the suprasellar cistern and deformed the left cerebral peduncle. At surgery, the tumor was firm to hard and attached to dura. Histologically the tumor was composed of spindle-cell proliferation in a collagen-rich background but exhibited regional variations. CD34 immunoreactivity was a prominent histologic finding. Ultrastructural features of meningioma, such as complex interdigitation of cell processes and intercellular specialized junctions were absent. The cells showed the typical appearances of fibroblasts with proximity of banded collagen and precollagen and cytoplasmic rough-surfaced endoplasmic reticulum. DNA ploidy analysis showed diploid DNA content. Awareness of this neoplasm may lead to increasingly frequent recognition and the current WHO classification of brain neoplasms should be modified to include this new entity.
authors.affiliation: Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
authors.forename: V R
authors.initials: VR
authors.lastname: Challa
authors.forename: S E
authors.initials: SE
authors.lastname: Kilpatrick
authors.forename: P
authors.initials: P
authors.lastname: Ricci
authors.forename: J A
authors.initials: JA
authors.lastname: Wilson
authors.forename: D L
authors.initials: DL
authors.lastname: Kelly
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D005350:Fibroma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D008579:Meningioma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011859:Radiography
chemical_list: D014408:Biomarkers, Tumor