Using information from both parents when testing for association between marker and disease loci.
Several extensions of the transmission/disequilibrium test (TDT) to multi-allelic markers now exist. In some of these, however, separate tests must be performed on male and female parents because of the non-independence of parental transmission patterns, reducing power, and complicating interpretation of the test results. Here we show that this non-independence is asymptotically irrelevant when using the allelic TDT of Bickeböller and Clerget-Darpoux [(1995) Genet Epidemiol 12:577-582], allowing the analysis of data from both parents simultaneously.
Whittaker
J C
JC
Department of Applied Statistics, University of Reading, UK. j.c.whittaker@reading.ac.uk
Morris
A P
AP
Curnow
R N
RN
D000483:Alleles; D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010290:Parents
D005819:Genetic Markers