title: DNA-damage and NAD(+)-depletion are initial events in oxygen radical induced islet cell death.
authors.affiliation: Diabetes-Forschungsinstitut, Heinrich-Heine Universität Düsseldorf, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Heller
authors.forename: A
authors.initials: A
authors.lastname: Bürkle
authors.forename: J
authors.initials: J
authors.lastname: Radons
authors.forename: E
authors.initials: E
authors.lastname: Fengler
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: V
authors.initials: V
authors.lastname: Burkart
authors.forename: H
authors.initials: H
authors.lastname: Kolb
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004249:DNA Damage; D019271:Hypoxanthine / Q000378:metabolism / Q000633:toxicity; D007515:Islets of Langerhans / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D009243:NAD / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D009243:NAD; D009536:Niacinamide; D019271:Hypoxanthine; D014969:Xanthine Oxidase; D011065:Poly(ADP-ribose) Polymerases