title: [Comparative analysis of distribution of mutant alleles of the gene coding for the CCR-5 chemokine receptor, among people in Russia, infected and not infected with HIV-1].
abstract: Comparative analysis of the distribution of deletion mutations of CC-chemokine receptor 5 (CCR-5) gene among HIV-1 infected and not infected subjects in Russia showed the incidence of the heterozygous genotype to be 17.8% among both HIV-infected and seronegative subjects. The incidence of the homozygous genotype for the deletion among seronegative individuals was 0.6%, but no homozygotes were found among HIV-1 infected patients. Study of the incidence of the mutant CCR-5 allele among patients infected with different HIV-1 subtypes showed that the susceptibility of heterozygotes to HIV-1 infection was not associated with any special genetic subtype.
authors.forename: E V
authors.initials: EV
authors.lastname: Kazennova
authors.forename: E
authors.initials: E
authors.lastname: Aarons
authors.forename: L M
authors.initials: LM
authors.lastname: Selimova
authors.forename: N N
authors.initials: NN
authors.lastname: Ladnaia
authors.forename: A V
authors.initials: AV
authors.lastname: Kravchenko
authors.forename: V E
authors.initials: VE
authors.lastname: Zhemchugov
authors.forename: R
authors.initials: R
authors.lastname: Chaingon-Popov
authors.forename: J
authors.initials: J
authors.lastname: Weber
authors.forename: V V
authors.initials: VV
authors.lastname: Pokrovskiĭ
authors.forename: A F
authors.initials: AF
authors.lastname: Bobkov
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018023:HIV Seronegativity / Q000235:genetics*; D015497:HIV-1; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009154:Mutation; D019713:Receptors, CCR5 / Q000235:genetics*; D012426:Russia; D017384:Sequence Deletion
chemical_list: D019713:Receptors, CCR5