title: The effect of hyperbaric oxygen on growth and chemosensitivity of metastatic prostate cancer.
abstract: BACKGROUND
  Currently, advanced prostate cancer (CaP) is not curable. In this report hyperbaric oxygen (HBO) is examined as an adjuvant to chemotherapy and as a stand-alone treatment.
  
  
  METHODS
  CaP cell monolayers grown under normoxic conditions were exposed to cisplatin, taxol or doxorubicin for 90 minutes under HBO (3.0 atmospheres, 100% O2) or normal pressure air.
  
  
  RESULTS
  HBO reduced by 47% the concentration of doxorubicin required to produce a 20% reduction in cell numbers, but did not change the concentration required to produce a > 50% reduction. HBO increased the sensitivity of PC-3 cells to taxol at all concentrations, (mean 1.8%). Cisplatin chemosensitivity was not affected by HBO. HBO reduced the growth rate of DU-145 8.1% relative to control (p = 0.01), and PC-3 2.7% (p = 0.12).
  
  
  CONCLUSIONS
  This study shows that HBO can decrease the rate of growth, and increase sensitivity to anticancer agents, however, the effects are cell line dependent.
authors.affiliation: AL/AOH, Brooks Air Force Base, TX 78235-5304, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kalns
authors.forename: L
authors.initials: L
authors.lastname: Krock
authors.forename: E
authors.initials: E
authors.lastname: Piepmeier
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D017239:Paclitaxel / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D017239:Paclitaxel; D002945:Cisplatin