title: Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones.
abstract: C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.
authors.affiliation: Public Health Research Institute, New York, New York 10016, USA.
authors.forename: X
authors.initials: X
authors.lastname: Zhao
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Xu
authors.forename: Y
authors.initials: Y
authors.lastname: Dong
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Domagala
authors.forename: K
authors.initials: K
authors.lastname: Drlica
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D027101:DNA Topoisomerase IV; D004250:DNA Topoisomerases, Type II / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology; D024841:Fluoroquinolones; D005798:Genes, Bacterial; D008826:Microbial Sensitivity Tests; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D011500:Protein Synthesis Inhibitors; D059005:Topoisomerase II Inhibitors; D002701:Chloramphenicol; D027101:DNA Topoisomerase IV; D004250:DNA Topoisomerases, Type II