Noxious heat-evoked fos-like immunoreactivity in the rat lumbar dorsal horn is inhibited by glutamate microinjections in the upper cervical spinal cord.
Microinjections of glutamate into the upper cervical spinal cord significantly reduced (to 57% of control) the total number of neurons demonstrating noxious heat-evoked fos-like immunoreactivity in the lumbar spinal cord. Neurons in the upper cervical spinal cord, with descending propriospinal projections to the lumbar spinal cord, therefore, produce inhibitory effects on dorsal horn neurons in the lumbar spinal cord that receive nociceptive input from cutaneous thermal nociceptors.
Jones
S L
SL
Department of Pharmacology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
D000818:Animals; D018698:Glutamic Acid / Q000494:pharmacology*; D006358:Hot Temperature; D007124:Immunoenzyme Techniques; D008161:Lumbosacral Region; D008297:Male; D008845:Microinjections; D009333:Neck / Q000294:innervation*; D009474:Neurons / Q000187:drug effects*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000737:chemistry / Q000187:drug effects*; D018709:Statistics, Nonparametric
D016760:Proto-Oncogene Proteins c-fos; D018698:Glutamic Acid