The effects of cyclosporin A on the polykaryocyte formation induced by measles virus in a monkey kidney cell line.
The effects of cyclosporin A (CsA) on the polykaryocyte formation induced by measles virus (MV) in a monkey kidney cell line (BSC-1) were studied. CsA inhibited virus-induced polykaryocyte formation as well as the production of infectious MV. The development of polykaryocyte formation in the presence of the CsA varied with virus strains, while pretreatment of the cells with 5 microM CsA for 24 hr before the virus infection enhanced polykaryocyte formation. These data demonstrated that CsA not only inhibits but also enhances virus-induced polykaryocyte formation depending on the conditions of its use.
Watari
E
E
Department of Microbiology and Immunology, Nippon Medical School, Tokyo.
Yokomuro
K
K
D000818:Animals; D002459:Cell Fusion / Q000187:drug effects; D002460:Cell Line; D016572:Cyclosporine / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015726:Giant Cells / Q000821:virology*; D000882:Haplorhini; D007668:Kidney / Q000166:cytology; D008459:Measles virus
D016572:Cyclosporine