title: Clinical application of two novel rapid bedside tests for the detection of cardiac troponin T and creatine kinase-MB mass/myoglobin in whole blood in acute myocardial infarction.
abstract: The objective of this study was to determine whether two novel rapid bedside assays for whole-blood detection of cardiac troponin T and creatine kinase (CK)-MB mass/myoglobin could rule out or rule in acute myocardial infarction in patients with acute chest pain. Ninety-two patients with chest pain <12 h prior to admission were investigated. No difference in the cumulative sensitivity of the TropT test and the CARDIAC STATus test (CK-MB mass and myoglobin in combination) was found 6 h after admission (94 vs. 97%). The cumulative positive predictive value of the TropT test and CARDIAC STATus test 6 h after admission was 97 and 76%, respectively. The negative predictive value was 97% for the TropT test and 98% for the CARDIAC STATus test at this time point. Our data show that the rapid assays provide diagnostic as well as prognostic information shortly after admission.
authors.affiliation: Department of Medicine and Cardiology, Aarhus University Hospital, Denmark.
authors.forename: M S
authors.initials: MS
authors.lastname: Lüscher
authors.forename: J
authors.initials: J
authors.lastname: Ravkilde
authors.forename: K
authors.initials: K
authors.lastname: Thygesen
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002637:Chest Pain / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D017023:Coronary Angiography; D003402:Creatine Kinase / Q000097:blood*; D003937:Diagnosis, Differential; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D009211:Myoglobin / Q000097:blood*; D019095:Point-of-Care Systems; D011379:Prognosis; D012680:Sensitivity and Specificity; D014336:Troponin / Q000097:blood*; D020107:Troponin T
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D009211:Myoglobin; D014336:Troponin; D020107:Troponin T; D003402:Creatine Kinase