Synthesis and antimicrobial evaluation of TAN-1057A/B analogs.
TAN-1057A-D, dipeptides isolated from bacteria Flexibacter sp. PK-74 and PK-176, are new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We describe, in detail, the synthesis of several TAN-1057A/B analogs by a convergent route featuring a new method to construct the cyclic amidinourea functional group. The biological activity of these substances against methicillin-resistant Staphylococcus aureus (MRSA) is reported.
Williams
R M
RM
Department of Chemistry, Colorado State University, Fort Collins 80523, USA.
Yuan
C
C
Lee
V J
VJ
Chamberland
S
S
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D004151:Dipeptides; C081415:TAN 1057A; C081416:TAN 1057B; C081417:TAN 1057C; C081418:TAN 1057D