The vascular biology of S-nitrosothiols, nitrosated derivatives of thiols.
Nitric oxide (NO) is a simple heterodiatomic molecule with a broad range of biologic actions. In the cardiovascular system NO serves as an endothelium-dependent vasodilator, an antithrombotic agent, an antiproliferative molecule, and a regulator of cardiac contractility. Owing to its reactivity under physiologic conditions, accumulating data suggest that NO forms derivatives with several classes of biologic compounds. One group of biochemical functionalities that serves this role is that of thiols, which can form thionitrites or S-nitrosothiols with NO. In this paper we will examine the effects of the biologically known and the chemically produced S-nitrosothiols on the cardiovascular system in order to understand better what role these compounds may play in physiologic and pathologic states.
Upchurch
G R
GR
Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118-2394, USA.
Welch
G N
GN
Loscalzo
J
J
D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena; D006801:Humans; D008623:Mercaptoethanol; D009569:Nitric Oxide / Q000502:physiology; D015538:Nitrosation; D009603:Nitroso Compounds / Q000378:metabolism*; D026403:S-Nitrosothiols; D013314:Stress, Mechanical; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism*
D009603:Nitroso Compounds; D026403:S-Nitrosothiols; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D008623:Mercaptoethanol; C032635:S-nitrosomercaptoethanol