Tetrahydroaminoacridine and D-cycloserine stimulate acquisition of water maze spatial navigation in aged rats.
We investigated the effect of tetrahydroaminoacridine, a cholinesterase inhibitor and D-cycloserine (a partial glycine-B agonist of the NMDA receptor complex) on the defect of water maze spatial navigation in rats induced by aging. Tetrahydroaminoacridine (3 mg/kg, i.p.) or D-cycloserine (10 mg/kg, i.p.) enhanced acquisition of the water maze task. A combination of subthreshold doses of tetrahydroaminoacridine (1 mg/kg) and D-cycloserine (3 mg/kg) improved water maze acquisition, but a combination of lower subthreshold doses (tetrahydroaminoacridine 0.3 mg/kg + D-cycloserine 1 mg/kg) was ineffective. Consolidation in water maze test was not improved by tetrahydroaminoacridine (3 mg/kg) and/or D-cycloserine (10 mg/kg). The results suggest that tetrahydroaminoacridine and D-cycloserine synergistically enhance acquisition of spatial navigation in aged rats.
Aura
J
J
Department of Neuroscience and Neurology, University of Kuopio, Finland.
Riekkinen
M
M
Riekkinen
P
P
D000375:Aging / Q000523:psychology; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003523:Cycloserine / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists*; D013268:Stimulation, Chemical; D013619:Tacrine / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate; D013619:Tacrine; D003523:Cycloserine