title: Synthesis and antimicrobial evaluation of TAN-1057A/B analogs.
abstract: TAN-1057A-D, dipeptides isolated from bacteria Flexibacter sp. PK-74 and PK-176, are new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We describe, in detail, the synthesis of several TAN-1057A/B analogs by a convergent route featuring a new method to construct the cyclic amidinourea functional group. The biological activity of these substances against methicillin-resistant Staphylococcus aureus (MRSA) is reported.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins 80523, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Williams
authors.forename: C
authors.initials: C
authors.lastname: Yuan
authors.forename: V J
authors.initials: VJ
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Chamberland
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D004151:Dipeptides; C081415:TAN 1057A; C081416:TAN 1057B; C081417:TAN 1057C; C081418:TAN 1057D