Identification of Nramp2 as an iron transport protein: another piece of the intestinal iron absorption puzzle.
Although a number of iron-binding proteins have been identified, the roles for specific proteins in mediating iron absorption have not been definitively assigned. Two recent papers report the identification of an iron transport protein that may be responsible for movement of iron from the intestinal lumen into the enterocyte. Coupled with the recent identification of the protein mutated in hemochromatosis, researchers are now establishing a clearer picture of the mechanism of intestinal iron absorption.
Fleet
J C
JC
University of North Carolina, Greensboro 27412-5001, USA.
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D027682:Cation Transport Proteins; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000378:metabolism / Q000493:pharmacokinetics*; D033862:Iron-Binding Proteins; D008565:Membrane Proteins / Q000502:physiology*; D000099173:Natural Resistance-associated Macrophage Protein 1; D000099236:Solute Carrier Family 11, Member 2
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D007501:Iron; D033862:Iron-Binding Proteins; D008565:Membrane Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1; D000099236:Solute Carrier Family 11, Member 2