Antioxidant activity of some ascorbic and cinnamic acids derivatives.
Some 4-benzoyl 3-hydroxy furan-2 (5H) ones (3a-d) and 2-amino 3-hydroxymethyl 4-aryl 4-oxo 2-butenoic acids (4a-h) have been synthesized. Compound 3c with an isobutyl substituent in the 5-position of the furan ring was the most effective (IC50 = 8.69 x 10(-4) M) in scavenging the superoxide anion. In vivo, 3c was also protective against reperfusion injury.
Point
D
D
Laboratoire de Pharmacie Clinique et Biotechnique, Faculté de Pharmacie, Clermont-Ferrand, France.
Coudert
P
P
Leal
F
F
Rubat
C
C
Sautou-Miranda
V
V
Chopineau
J
J
Couquelet
J
J
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002934:Cinnamates / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011817:Rabbits; D013329:Structure-Activity Relationship
D000975:Antioxidants; D002934:Cinnamates; C029010:cinnamic acid; D001205:Ascorbic Acid