X-linked locus is responsible for non-insulin-dependent diabetes mellitus in the OLETF rat.
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat has been recently established as the best model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. In this study, we found that the F1 progeny produced from the crosses of OLETF and F344 rats exhibit a reciprocal cross effect on NIDDM-relevant phenotypes, fasting and postprandial glucose levels and body weight, suggesting the existence of X-linked locus affecting susceptibility to NIDDM. We thus examined the linkage between 7 X-linked microsatellite markers and NIDDM-relevant phenotypes, using 160 (OLETF x F344)F2 progeny. Suggestive evidence for a X-linked locus affecting glucose levels at 120 min after glucose administration was found in a region near X-linked marker, DXMgh4. The identified locus also showed significant effects on fasting glucose levels and body weight.
Moralejo
D H
DH
Institute for Animal Experimentation, University of Tokushima School of Medicine, Japan.
Wei
S
S
Wei
K
K
Yamada
T
T
Matsumoto
K
K
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003920:Diabetes Mellitus / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005951:Glucose Tolerance Test; D008297:Male; D018895:Microsatellite Repeats; D009765:Obesity; D010641:Phenotype; D019518:Postprandial Period; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D014960:X Chromosome
D001786:Blood Glucose; D005819:Genetic Markers