Consumption of fatty fish from the Baltic Sea and PCB in whole venous blood, plasma and cord blood from delivering women in the Aland/Turku archipelago.
The present study aimed to assess the role of fish consumption for the body burden of polychlorinated biphenyls (PCBs) in mothers living in the Aland and Turku archipelago in Finland. The overall objective was to investigate whether there exists an appropriate population for a full-scale prospective study on PCB-related developmental effects in infants. Concentrations of the four major PCBs were determined in whole venous blood and cord blood from 30 delivering mothers, of which 20 subjects consumed fatty fish from the Baltic Sea (2.5-12.5 meals per month) and the remaining 10 mothers did not. The concentrations of CB-118, CB-138, CB-153, and CB-180 in cord blood were generally two- to threefold lower than in whole blood from the mothers, but strong correlations were observed between PCBs in the two matrices (r = .67-.80). Neither the venous blood nor cord blood concentrations of PCBs, however, were correlated with stated fish intake. Moreover, the concentration of CB-153 in plasma was only weakly associated with fish intake, and the level of organic mercury in erythrocytes was not correlated with fish intake at all. The present results of CB-153 concentrations in women's blood are lower than those reported in other recent investigations. A reasonable contributing explanation is the rapid decline during the last decades of PCB in Baltic Sea fish, which has resulted in less impact of fish intake on the body burdens of PCB in relatively young women (median 30 yr in the present study) as compared with older females. The relatively low PCB levels in blood taken together with the low number of yearly deliveries in the archipelago population makes it an inappropriate study base for a prospective study of PCB-related health effects in infants.
Hagmar
L
L
Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden. lars.hagmar@ymed.lu.se
Becher
G
G
Heikkilä
A
A
Frankman
O
O
Dyremark
E
E
Schütz
A
A
Ahlborg
U G
UG
Dybing
E
E
D000328:Adult; D000818:Animals; D001822:Body Burden; D004032:Diet; D004787:Environmental Pollution; D016021:Epidemiologic Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005387:Finland; D005399:Fishes; D005506:Food Contamination; D006801:Humans; D007231:Infant, Newborn; D010865:Pilot Projects; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000493:pharmacokinetics*; D011247:Pregnancy; D012016:Reference Values; D014874:Water Pollutants, Chemical / Q000009:adverse effects*
D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls