title: Comparative in vitro killing activities of meropenem, imipenem, ceftriaxone, and ceftriaxone plus vancomycin at clinically achievable cerebrospinal fluid concentrations against penicillin-resistant Streptococcus pneumoniae isolates from children with meningitis.
abstract: The activities of meropenem, imipenem, ceftriaxone, and vancomycin were evaluated against 80 penicillin-susceptible and -resistant Streptococcus pneumoniae strains. Meropenem, imipenem, ceftriaxone, and vancomycin MICs at which 90% of the isolates are inhibited were 0.5, 0.25, 1, and 0.25 microg/ml, respectively. Against penicillin-resistant strains, the best killing activity at cerebrospinal fluid concentrations was obtained with imipenem and ceftriaxone-vancomycin. However, while the killing activity of imipenem was significantly greater than that of meropenem, no significant difference was observed between the activities of meropenem and ceftriaxone-vancomycin.
authors.affiliation: Service de Microbiologie, Hôpital Robert Debré, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Fitoussi
authors.forename: C
authors.initials: C
authors.lastname: Doit
authors.forename: K
authors.initials: K
authors.lastname: Benali
authors.forename: S
authors.initials: S
authors.lastname: Bonacorsi
authors.forename: P
authors.initials: P
authors.lastname: Geslin
authors.forename: E
authors.initials: E
authors.lastname: Bingen
mesh_terms: D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D015780:Carbapenems / Q000134:cerebrospinal fluid / Q000494:pharmacology; D002443:Ceftriaxone / Q000134:cerebrospinal fluid / Q000494:pharmacology; D002511:Cephalosporins / Q000134:cerebrospinal fluid / Q000494:pharmacology; D002648:Child; D004359:Drug Therapy, Combination / Q000134:cerebrospinal fluid / Q000494:pharmacology; D006801:Humans; D015378:Imipenem / Q000134:cerebrospinal fluid / Q000494:pharmacology; D008586:Meningitis, Pneumococcal / Q000382:microbiology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013845:Thienamycins / Q000134:cerebrospinal fluid / Q000494:pharmacology; D014640:Vancomycin / Q000134:cerebrospinal fluid / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002511:Cephalosporins; D013845:Thienamycins; D014640:Vancomycin; D015378:Imipenem; D002443:Ceftriaxone; D000077731:Meropenem