title: Superficial vein thrombosis: incidence in association with pregnancy and prevalence of thrombophilic defects.
abstract: Superficial venous thrombotic (SVT) events are a feature of thrombophilic abnormalities, particularly those involving the protein C pathway. We have determined the incidence of SVT associated with pregnancy and the early postpartum period in a retrospective study involving 72000 deliveries. Fourty-nine cases occurring in 47 individuals were recorded, with an overall incidence of 0.68/1000 deliveries (95% CI 0.48-0.88). None had a previous history of deep vein thrombosis or pulmonary embolism. Most events occurred in the early postpartum period (0.54/1000 deliveries). Twenty-four/fourty-seven were screened for established thrombophilic abnormalities, with only 1 abnormality detected (FV(Leiden) heterozygote). Thrombophilia may play a minor role in the aetiology of SVT associated with pregnancy, although a larger study is required to confirm this.
authors.affiliation: Dept. of Haematology, Royal Infirmary, Glasgow, UK. MMccoll1@aol.com
authors.forename: M D
authors.initials: MD
authors.lastname: McColl
authors.forename: J E
authors.initials: JE
authors.lastname: Ramsay
authors.forename: R C
authors.initials: RC
authors.lastname: Tait
authors.forename: I D
authors.initials: ID
authors.lastname: Walker
authors.forename: F
authors.initials: F
authors.lastname: McCall
authors.forename: J A
authors.initials: JA
authors.lastname: Conkie
authors.forename: M J
authors.initials: MJ
authors.lastname: Carty
authors.forename: I A
authors.initials: IA
authors.lastname: Greer
mesh_terms: D000328:Adult; D015897:Comorbidity; D005165:Factor V / Q000032:analysis / Q000235:genetics; D005260:Female; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology* / Q000209:etiology; D011486:Protein C / Q000032:analysis; D011644:Puerperal Disorders / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012606:Scotland / Q000453:epidemiology; D019851:Thrombophilia / Q000150:complications / Q000453:epidemiology*; D013924:Thrombophlebitis / Q000453:epidemiology* / Q000209:etiology
chemical_list: D011486:Protein C; C095381:factor V Leiden; D005165:Factor V