title: Skin as the primary site of Hodgkin's disease: a case report of primary cutaneous Hodgkin's disease and review of its relationship with non-Hodgkin's lymphoma.
abstract: We report an elderly patient who presented with a single cutaneous nodule of primary cutaneous Hodgkin's disease (PCHD). Reed-Sternberg cells, expressing CD30 and CD15, but not leukocyte common antigen (CD45RB), were identified in the neoplastic cells. Southern blot analysis failed to detect T-cell receptor or immunoglobulin gene rearrangement. A work-up for systemic disease at the time of presentation was negative, supporting the diagnosis of PCHD. Nevertheless, 1 year later, the disease course was complicated by the development of nodal HD and nonHodgkin's lymphoma (NHL). This case report supports the existence of this rare, but distinct, cutaneous tumor.
authors.affiliation: Department of Dermatology, Northwestern University Medical Center, Chicago, Illinois 60611, USA.
authors.forename: J
authors.initials: J
authors.lastname: Guitart
authors.forename: D
authors.initials: D
authors.lastname: Fretzin
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D017730:Ki-1 Antigen