The role of bronchoalveolar lavage in the microbiological diagnosis of pneumonia in patients with haematological malignancies.
In the aetiological diagnosis of pulmonary infections in patients affected by haematological malignancies we evaluated the utility of bronchoalveolar lavage (BAL). One hundred and twenty-seven BAL were performed in 119 patients. In our series, we identified the agent of pneumonia in 53.5% of episodes with the best results in aspergillosis, very common in these patients. The previous empirical anti-infective treatment was modified in 14 episodes (11%). The procedure was generally well tolerated and only one patient bled. We maintain that BAL is a useful diagnostic tool for detecting the agents of pulmonary infections in patients with haematological malignancies, especially when the routine microbiological procedures fail, and it also represents a good alternative to more invasive procedures.
Pagano
L
L
Istituto di Semeiotica Medica, Università Cattolica del Sacro Cuore, Rome, Italy. liviop@usa.net
Pagliari
G
G
Basso
A
A
Marra
R
R
Sica
S
S
Frigieri
L
L
Morace
G
G
Ardito
F
F
Leone
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy; D018893:Bronchoalveolar Lavage / Q000009:adverse effects; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology / Q000821:virology; D001999:Bronchoscopy; D005069:Evaluation Studies as Topic; D005260:Female; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy; D008223:Lymphoma / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D011024:Pneumonia, Viral / Q000175:diagnosis; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis
D000890:Anti-Infective Agents