DNA-damage and NAD(+)-depletion are initial events in oxygen radical induced islet cell death.
Heller
B
B
Diabetes-Forschungsinstitut, Heinrich-Heine Universität Düsseldorf, Germany.
Bürkle
A
A
Radons
J
J
Fengler
E
E
Müller
M
M
Burkart
V
V
Kolb
H
H
D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004249:DNA Damage; D019271:Hypoxanthine / Q000378:metabolism / Q000633:toxicity; D007515:Islets of Langerhans / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D009243:NAD / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D014969:Xanthine Oxidase / Q000378:metabolism
D017382:Reactive Oxygen Species; D009243:NAD; D009536:Niacinamide; D019271:Hypoxanthine; D014969:Xanthine Oxidase; D011065:Poly(ADP-ribose) Polymerases