Effects of imipramine and sertraline on protein kinase activity in rat frontal cortex.
Three-week administration of sertraline or imipramine to rats (10 mg/kg, intraperitoneally, twice a day) increased ex vivo cyclic AMP-dependent protein kinase activity in the soluble but not in the particulate fraction of the frontal cortex. However, cyclic AMP-dependent protein kinase activity was not affected in either fraction of the parietotemporal cortex and hippocampus. Neither antidepressant altered protein kinase C activity in the soluble and particulate fractions or Ca2+/calmodulin-dependent protein kinase II activity in the frontal cortex. Therefore, sertraline and imipramine both selectively enhance cyclic AMP-dependent protein kinase activity in the frontal cortex. This enhancement might be involved in their biochemical mechanisms.
Tadokoro
C
C
Department of Psychiatry, School of Medicine, Showa University, Tokyo, Japan.
Kiuchi
Y
Y
Yamazaki
Y
Y
Oguchi
K
K
Kamijima
K
K
D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D010296:Parietal Lobe / Q000187:drug effects / Q000201:enzymology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000201:enzymology*; D011493:Protein Kinase C / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D020280:Sertraline; D013702:Temporal Lobe / Q000187:drug effects / Q000201:enzymology
D015057:1-Naphthylamine; D000929:Antidepressive Agents, Tricyclic; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D007099:Imipramine; D011493:Protein Kinase C; D011494:Protein Kinases; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline