title: Stem cell transplantation into the fetal recipient: challenges and prospects.
abstract: The interest in therapeutic intervention for those inherited disorders that can be diagnosed early in pregnancy has recently intensified. In-utero transplantation of haematopoietic stem cells (IUT-HSC), a therapy which could be proffered before pathological manifestations of a disorder become apparent, offers considerable potential benefit. However, as reports of IUT-HSC procedures become more prolific, it is necessary to consider the optimum modus operandi for each group of disorders targeted for therapy in order to develop effective procedures that make a real difference to the outcome. This review outlines the current status and prospects of IUT-HSC. It also offers a view of some of the challenges for IUT-HSC to overcome to find wider clinical applications.
authors.affiliation: Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden. bui@gen.ks.se
authors.forename: T H
authors.initials: TH
authors.lastname: Bui
authors.forename: D R
authors.initials: DR
authors.lastname: Jones
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First