Analysis of antigen receptor signalling using mouse gene targeting.
Gene targeting in mice has enabled the study of antigen receptor signalling in primary lymphocytes. Furthermore, it has provided the tools to directly assess the function of individual signalling proteins by mutation of the genes that code for them. Some of the results that gene targeting has produced have confirmed previous views of the function of particular proteins. Others have given surprising results and overturned accepted viewpoints.
Tybulewicz
V L
VL
National Institute for Medical Research, Mill Hill, London, UK. v-tybule@nimr.mrc.ac.uk
D000818:Animals; D018390:Gene Targeting; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics* / Q000276:immunology*
D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell