title: Piperacillin/tazobactam therapy for diabetic foot infection.
abstract: In this study, 29 patients were hospitalized with a diabetic foot infection and were treated with piperacillin/tazobactam. Of these 23 patients who were evaluated for efficacy of treatment, 22 patients improved or were clinically cured. In seven patients (30%), there was persistence of one of the baseline pathogens. Adverse events were reported in 15 patients (58%), three of which were serious. Piperacillin/tazobactam may be useful as monotherapy in diabetic foot infection giving an adequate clinical response and the level of side effects equivalent to those of other broad-spectrum antibiotics.
authors.affiliation: Department of Surgery, Diakonessen Hospital, Utrecht, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: Zeillemaker
authors.forename: K E
authors.initials: KE
authors.lastname: Veldkamp
authors.forename: M G
authors.initials: MG
authors.lastname: van Kraaij
authors.forename: J B
authors.initials: JB
authors.lastname: Hoekstra
authors.forename: A A
authors.initials: AA
authors.lastname: Hoynck van Papendrecht
authors.forename: R J
authors.initials: RJ
authors.lastname: Diepersloot
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017719:Diabetic Foot / Q000150:complications / Q000188:drug therapy*; D004338:Drug Combinations; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010397:Penicillanic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010406:Penicillins / Q000009:adverse effects / Q000627:therapeutic use*; D010878:Piperacillin / Q000009:adverse effects / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology; D000078142:Tazobactam
chemical_list: D004338:Drug Combinations; D004791:Enzyme Inhibitors; D010406:Penicillins; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin