Dual effect of propranolol on the human platelet activation by thrombin: potentiation of free intracellular Ca2+ mobilization and inhibition of phospholipase D activity.
Svetlov
S I
SI
Department of Biochemistry, University of Texas Health Science Center, San Antonio 78240-7760, USA.
Hanahan
D J
DJ
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D020404:Glycerophospholipids; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D009281:Naphthalenes / Q000494:pharmacology; D010712:Phosphatidic Acids / Q000097:blood; D010739:Phospholipase D / Q000037:antagonists & inhibitors / Q000097:blood*; D015539:Platelet Activation / Q000187:drug effects* / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D013917:Thrombin / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D020404:Glycerophospholipids; D009281:Naphthalenes; D010712:Phosphatidic Acids; C051521:phosphatidylethanol; D011433:Propranolol; D011493:Protein Kinase C; D010739:Phospholipase D; D013917:Thrombin; C058819:calphostin C; D002118:Calcium