Single-dose cefodizime as infection prophylaxis in abdominal surgery: a prospective multicenter study.
This prospective pilot study was performed to evaluate the efficacy, safety and tolerability of a single dose of cefodizime as infection prophylaxis in patients undergoing major abdominal surgery. One hundred forty-nine patients received 2g cefodizime, a third-generation cephalosporin, 30 min before abdominal surgery. The mean operation time was 116 +/- 66 min. Eighteen patients received metronidazole additionally. In 8/149 patients (5.4%) the final outcome was considered to be a treatment failure. 94.6% of the patients had no signs of infection. The long half-life of cefodizime allows a single-dose perioperative prophylaxis even in abdominal surgery lasting 3 to 4 h. Cefodizime can be regarded as a safe antibiotic prophylaxis with few side effects.
Thalhammer
F
F
Universitätsklinik für Innere Medizin I, Klinische Abt. für Infektionen und Chemotherapie, Wien, Austria.
Traunmüller
F
F
Böhming
H J
HJ
Depisch
D
D
Ilias
W
W
Hollenstein
U
U
Salem
G
G
Wayand
W
W
Burgmann
H
H
Breyer
S
S
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control*; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002511:Cephalosporins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies
D002511:Cephalosporins; D002439:Cefotaxime; C033356:cefodizime