title: Cerebral perfusion pressure and intracranial pressure in relation to neuropsychological outcome.
abstract: OBJECTIVE
  The study attempted to examine the relationship between neuropsychological functioning and reduced cerebral perfusion pressure (CPP), raised intracranial pressure (ICP), and reduced mean arterial pressure (MAP), monitored during intensive care treatment.
  
  
  METHODS
  This prospective follow-up study included consecutive patients and evaluated outcome at 6 months postinjury by the administration of a neuropsychological test battery.
  
  
  METHODS
  The study was conducted at the University Hospital of Gent, Belgium.
  
  
  METHODS
  Over a 30-month period, 43 patients were included. Inclusion criteria were the following: hospital admission following closed head injury. ICP monitoring, no medical history of central nervous system disease or mental retardation, survival for at least 6 months, and informed consent for participation.
  
  
  METHODS
  All patients received the hospital's standard treatment for head injury, which remained unchanged during the study period.
  
  
  RESULTS
  Reduced CPP was analyzed using the number of observed values below 70 mmhg, raised ICP using the number of values above 20 mmHg, and MAP using the number of values below 80 mmHg. The neuropsychological test battery included 11 measures of attention, information processing, motor reaction time, memory, learning, visuoconstruction, verbal fluency, and mental flexibility. No linear relationships were found between overall neuropsychological impairment and episodes of reduced CPP, raised ICP, or reduced MAP.
  
  
  CONCLUSIONS
  Although reduced CPP and raised ICP are frequent, often fatal, complications of head injury, in survivors they do not seem to be related to later neuropsychological functioning.
authors.affiliation: Department of neuropsychology 4K3, Gent, Belgium Engelien. Lannoo@rug.ac.be
authors.forename: E
authors.initials: E
authors.lastname: Lannoo
authors.forename: F
authors.initials: F
authors.lastname: Colardyn
authors.forename: C
authors.initials: C
authors.lastname: De Deyne
authors.forename: T
authors.initials: T
authors.lastname: Vandekerckhove
authors.forename: C
authors.initials: C
authors.lastname: Jannes
authors.forename: G
authors.initials: G
authors.lastname: De Soete
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000209:etiology*; D002560:Cerebrovascular Circulation; D006259:Craniocerebral Trauma / Q000150:complications* / Q000503:physiopathology*; D003422:Critical Care; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008991:Monitoring, Physiologic; D009483:Neuropsychological Tests; D011379:Prognosis; D011446:Prospective Studies; D016896:Treatment Outcome