title: [Acute perceptive hearing loss and metabolic acidosis as complications of the topical treatment of psoriasis with salicylic acid-containing ointment].
abstract: A 36-year-old woman, hospitalized because of an exacerbation of psoriasis, developed fever, sudden deafness and severe metabolic acidosis after treatment with a 10% salicylic acid containing ointment for four days. The use of salicylic acid on large areas of inflamed skin enhances the risk of transcutaneous resorption and intoxication. High serum concentrations (> 300 mg/l) of salicylic acid deregulate the blood glucose metabolism and cause damage to the inner ear. After timely intervention such symptoms are largely reversible.
authors.affiliation: Afd. Dermatologie, Ziekenhuis Walcheren, Vlissingen.
authors.forename: S F
authors.initials: SF
authors.lastname: Jongevos
authors.forename: E P
authors.initials: EP
authors.lastname: Prens
authors.forename: J H
authors.initials: JH
authors.lastname: Wolterbeek
authors.forename: J M
authors.initials: JM
authors.lastname: Habets
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D009824:Ointments; D011565:Psoriasis / Q000188:drug therapy*; D012459:Salicylates / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism
chemical_list: D007641:Keratolytic Agents; D009824:Ointments; D012459:Salicylates