Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release.
The prolactin responses to the serotonin (5-HT) releasing agent d-fenfluramine (30 mg orally) were studied in 11 male normal volunteers after administration of hydrocortisone (20 mg orally, twice daily for 10 days) using a double-blind, placebo-controlled, cross-over design. While hydrocortisone treatment significantly elevated 24-h urinary cortisol excretion, it did not lower the prolactin response to d-fenfluramine. Plasma levels of d-fenfluramine and d-norfenfluramine were not altered by hydrocortisone treatment. These findings show that following 10 days administration of hydrocortisone, the prolactin responses to d-fenfluramine are not changed.
Young
A H
AH
University Department of Psychiatry, Littlemore Hospital, Oxford, UK.
Rue
J
J
Odontiadis
J
J
Cowen
P J
PJ
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D011388:Prolactin / Q000097:blood*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D005277:Fenfluramine; D006854:Hydrocortisone; D011388:Prolactin; D017367:Selective Serotonin Reuptake Inhibitors