Self-stimulation from the mesencephalon following intraventricular interleukin-2 administration.
Intracranial self-stimulation was evaluated among CD-1 mice responding for brain stimulation from the dorsal and ventral aspects of the ventral tegmental area (VTA). Intraventricular interleukin-2 (IL-2) administration (5 ng) in a 1-microl volume elevated the stimulation frequency required to effect half-maximal responding for brain stimulation from the dorsal A10 region 15 min, 24 h, 48 h, and 1 week following drug administration relative to vehicle-treated animals. Intraventricular IL-2 administration did not influence responding for brain stimulation from the ventral A10 area, and performance of these animals was indistinguishable from the performance of vehicle-challenged animals implanted with a stimulating electrode in the ventral A10 area. These data suggest that central IL-2 administration reduces the value of previously rewarding brain stimulation from subregions of the VTA. The implications of these data for behavioural pathology are discussed.
Hebb
A L
AL
Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Zacharko
R M
RM
Anisman
H
H
D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D007276:Injections, Intraventricular; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008845:Microinjections; D012653:Self Stimulation / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D007376:Interleukin-2