title: Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control.
abstract: The proliferating cell nuclear antigen (PCNA), the auxiliary protein of DNA polymerase delta and epsilon, is involved in DNA replication and repair. This protein forms a homotrimeric structure which, encircling DNA, loads the polymerase on the DNA template. A role for PCNA in the cell cycle control is recognised on the basis of the interaction with cyclins, cyclin-dependent kinases (cdks) and the cdk-inhibitor p21 waf1/cip1/sdi1 protein. Association with the growth-arrest and DNA-damage inducible proteins gadd45 and MyD118, further demonstrates the role of PCNA as a component of the cell cycle control apparatus.
authors.affiliation: Dipartimento di Biologia Animale, Università di Pavia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Prosperi
mesh_terms: D000818:Animals; D001665:Binding Sites; D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism; D004260:DNA Repair / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D018809:Proliferating Cell Nuclear Antigen / Q000737:chemistry / Q000502:physiology*
chemical_list: D016213:Cyclins; D004791:Enzyme Inhibitors; D046911:Macromolecular Substances; D018809:Proliferating Cell Nuclear Antigen; D018844:Cyclin-Dependent Kinases