Extrarolandic origin of spike and myoclonus activity in epilepsia partialis continua: a magnetoencephalographic and positron emission tomography study.
The dipole sources of interictal spike activity were localized and the myoclonus activity back-averaged by combined magnetoencephalography and surface electromyographic measurements in a child who had epilepsia partialis continua without a structural brain lesion. Dipole sources were matched with metabolic information obtained from interictal 5-fluoro-D-glucose positron emission tomography (PET) and superimposed onto high-resolution magnetic resonance images. Dipole sources of interictal epileptic discharges clustered within the inferior parietal cortex, which also showed a regional hypermetabolism on PET scans. The dipole sources of reafferent activity following myocloni in the postcentral gyrus were associated with a local hypometabolism Although there was no obvious phase relationship between interictal spikes and myoclonic jerks, the myocloni were initiated from within the interictal spike area in the extrarolandic cortex. The data demonstrate that motor symptoms may be a remote effect of epileptic activity within functional brain circuits.
Volkmann
J
J
Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany.
Seitz
R J
RJ
Müller-Gärtner
H W
HW
Witte
O W
OW
D002648:Child; D004831:Epilepsies, Myoclonic / Q000378:metabolism / Q000503:physiopathology; D004828:Epilepsies, Partial / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D014055:Tomography, Emission-Computed