title: Characteristics of biochemical markers in patients with metabolic bone disorders.
abstract: Biochemical markers of bone turnover are expected to have some different characteristics among bone metabolic disorders. We compared bone formation markers: serum total alkaline phosphatase (s-Alp), serum osteocalcin (s-OC) and serum carboxy-terminal propeptide of type I collagen (s-PICP); and bone resorption markers: serum carboxy-terminal telopeptide of type I collagen (s-ICTP), urinary pyridinoline (u-Pyr) and urinary deoxypyridinoline (u-Dpyr) to examine which marker is the most suitable and reliable to evaluate bone turnover in patients with osteoporosis (n = 29), osteomalacia (n = 10), primary hyperparathyroidism (n = 6) and renal osteodystrophy (n = 21). The value of s-Alp in the osteomalacia group was significantly higher than those in the normal control group and the osteoporosis group (p < 0.001), and T-score of s-Alp was significantly higher than those of s-OC and s-PICP in the osteomalacia group. The values of u-Pyr and u-Dpyr in the primary hyperparathyroidism group were significantly higher than those in the other groups (p < 0.001). S-PICP, which are not dependent upon renal function, was much higher in the renal osteodystrophy group than in all other groups. In the osteoporosis group, T-score of s-ICTP was significantly higher than those of s-OC. Thus, s-Alp was a good marker in osteomalacia, u-Pyr and u-Dpyr in primary hyperparathyroidism, s-PICP in renal osteodystrophy, and s-ICTP in osteoporosis.
authors.affiliation: Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hoshino
authors.forename: K
authors.initials: K
authors.lastname: Kushida
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Kawana
authors.forename: M
authors.initials: M
authors.lastname: Denda
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D000596:Amino Acids / Q000652:urine*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood / Q000652:urine; D015331:Cohort Studies; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000652:urine; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D010018:Osteomalacia / Q000097:blood / Q000652:urine; D010024:Osteoporosis / Q000097:blood / Q000652:urine; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D012016:Reference Values
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; C015484:pyridinoline; C036020:deoxypyridinoline; D003094:Collagen; D000469:Alkaline Phosphatase