Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila.
The development and patterning of the Drosophila wing relies on interactions between cell populations that have the anteroposterior (AP) axis and dorsoventral (DV) axis of the wing imaginal disc as frames of reference [1-3]. Each of these cell populations gives rise to a compartment - a group of cells that have their fates restricted by cell lineage - within which cells acquire specific identities through the expression of 'selector' genes [1,2,4]. The genes engrailed (en) and invected (inv), for example, label cells in the posterior compartment and mediate a set of cell interactions that direct the patterning and growth of the wing along the AP axis [1,2,4]. A similar situation has been proposed to exist across the DV axis, along with apterous (ap) as a dorsal selector gene [5], mediating cell interactions by regulating the expression of Serrate (Ser) [6] [7] and fringe (fng) [8]. In ap mutants, the wing is lost [5] [9], and here we report that this phenotype can be rescued by ectopic expression of either Ser or fng and that, surprisingly, the resulting wings have both dorsal and ventral cell fates.
Klein
T
T
Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK. thk21@cus.cam.ac.uk
Couso
J P
JP
Martinez Arias
A
A
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002135:Calcium-Binding Proteins; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D018398:Homeodomain Proteins; D019476:Insect Proteins / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D060850:LIM-Homeodomain Proteins; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation; D017351:N-Acetylglucosaminyltransferases; D010641:Phenotype; D000072099:Serrate-Jagged Proteins; D014157:Transcription Factors / Q000235:genetics*; D014921:Wings, Animal / Q000254:growth & development* / Q000378:metabolism
D002135:Calcium-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; D036341:Intercellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D060850:LIM-Homeodomain Proteins; D008565:Membrane Proteins; C000606278:Ser protein, Drosophila; D000072099:Serrate-Jagged Proteins; D014157:Transcription Factors; C074459:ap protein, Drosophila; D017351:N-Acetylglucosaminyltransferases; C090576:fng protein, Drosophila