title: Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals.
abstract: Although alkyl epoxides are difficult to synthesize in enantiomerically pure form they can often be prepared by the enantioselective hydrolysis of racemic epoxide. The best methods for this transformation are all catalytic and they illustrate the complementary role that biological and synthetic catalysts can play in organic chemistry.
authors.affiliation: Department of Chemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA. nfinney@chem.ucsd.edu
authors.forename: N S
authors.initials: NS
authors.lastname: Finney
mesh_terms: D017151:Antibodies, Catalytic / Q000737:chemistry; D000959:Antihypertensive Agents / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry; D002384:Catalysis; D004110:Diltiazem / Q000737:chemistry; D034261:Epothilones; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006868:Hydrolysis; D007166:Immunosuppressive Agents / Q000737:chemistry; D016559:Tacrolimus / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry
chemical_list: D017151:Antibodies, Catalytic; D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D034261:Epothilones; D004852:Epoxy Compounds; D007166:Immunosuppressive Agents; D013844:Thiazoles; C093787:epothilone A; D004110:Diltiazem; D016559:Tacrolimus