A new lysine derivative and new 3-bromopyrrole carboxylic acid derivative from two marine sponges.
A novel lysine derivative, 1, has been isolated from the marine sponge Axinyssa terpnis, in addition to 4alpha-isocyanogorgon-11-ene and related compounds (2-4). From the marine sponge Axinella carteri, the new 3-bromopyrrole carboxylic acid derivative, 5, was obtained along with the known compounds aldisin (6) and 2-bromoaldisin (7). Both sponges were collected from Chuuk Atoll, Federated States of Micronesia. The compounds were characterized by spectroscopic and chemical methods.
Li
C J
CJ
Department of Chemistry and Biochemistry, The University of Oklahoma, Norman 73019-0370, USA.
Schmitz
F J
FJ
Kelly-Borges
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia; D002264:Carboxylic Acids / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D002264:Carboxylic Acids