Hemodynamic and metabolic effects of CO2 pneumoperitoneum in an experimental model of hemorrhagic shock due to retroperitoneal hematoma.
BACKGROUND
Diagnostic laparoscopy has been used in abdominal trauma patients, although its role is not well defined. The safety of laparoscopic evaluation in trauma patients with severe intraabdominal hemorrhage has not yet been analyzed. The purpose of this study is to evaluate the hemodynamic and metabolic effects of CO2 pneumoperitoneum (COI) in hemorrhaged animals through a retroperitoneal hematoma (RH).


METHODS
Twenty-two 15-20-kg mongrel dogs were monitored for systemic and pulmonary hemodynamics, inferior vena cava pressure, and arterial blood gases. After 1 h of baseline, all animals were submitted to a RH. After 45 min the dogs were randomized into two groups. Control (CTR): dogs were submitted only to a RH; pneumoperitoneum (PN): dogs were submitted to a RH and 45 min later they were insufflated to an intraabdominal pressure of 10 mmHg with medical-grade CO2 gas for 30 min. Echocardiography was performed, only in PN animals, at baseline, 45 and 60 min after RH.


RESULTS
RH induced a shock condition with low, sustained levels of arterial pressure, cardiac index, left ventricular stroke index, base excess, and oxygen delivery which were further depressed following COI. Three deaths occurred in the PN group, all of them toward the end of COI. During COI, hypercapnia was observed in one animal. COI did not impair systolic function or ejection fraction.


CONCLUSIONS
COI with an IAP of 10 mmHg may be deleterious in animals with hemorrhagic shock due to an intraabdominal lesion. These findings could be clinically significant in abdominal trauma patients.
Steinman
M
M
Trauma Division, Department of Surgery, Hospital das Clínicas-University of São Paulo-Brazil.
da Silva
L E
LE
Coelho
I J
IJ
Poggetti
R S
RS
Bevilacqua
R G
RG
Birolini
D
D
Rocha e Silva
M
M
D000818:Animals; D001810:Blood Volume; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D006406:Hematoma / Q000150:complications*; D006439:Hemodynamics; D006863:Hydrogen-Ion Concentration; D010535:Laparoscopy; D010100:Oxygen / Q000097:blood; D011028:Pneumoperitoneum, Artificial; D012187:Retroperitoneal Space; D012771:Shock, Hemorrhagic / Q000097:blood / Q000209:etiology / Q000503:physiopathology*
D002245:Carbon Dioxide; D010100:Oxygen