title: Investigation of the clinical value of total saliva flow rates.
abstract: The symptom of dry mouth was correlated with unstimulated (UWSFR) and stimulated (SWSFR) whole-saliva flow rate on chewing medical paraffin in 62 patients with dry-mouth complaints (30 with Sjögren's syndrome, 32 with sialosis) and 23 controls. The symptom of dry mouth was classified into grades 0,1,2,3,4 according to a Treatment Emergent Symptom Scale (TESS). UWSFR and SWSFR were determined after fasting in the morning. UWSFR was 0.070 +/- 0.089 ml/min in Sjögren's syndrome, 0.175 +/- 0.115 ml/min in sialosis, 0.330 +/- 0.188 ml/min in controls. SWSFR was 0.709 +/- 0.720 ml/min in Sjögren's syndrome, 1.561 +/- 0.867 ml/min in sialosis, 1.894 +/- 0.661 ml/min in controls. A highly significant correlation was found between TESS score and UWSFR and between TESS score and SWSFR. Only UWSFR was decreased in the patients with a TESS score of 1 or 2, while both UWSFR and SWSFR were significantly decreased in the patients with TESS scores of 3, 4. It is concluded that UWSFR is more sensitive in relation to dry-mouth complaints than SWSFR, and that a mild dry mouth is mainly related to decreased UWSFR.
authors.affiliation: Salivary Gland Disease Center, Beijing Hospital for Stomatology, Capital University of Medical Sciences, P. R. China.
authors.forename: S L
authors.initials: SL
authors.lastname: Wang
authors.forename: Z T
authors.initials: ZT
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: X Z
authors.initials: XZ
authors.lastname: Zhu
authors.forename: H
authors.initials: H
authors.lastname: Dong
authors.forename: Y G
authors.initials: YG
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D008409:Mastication; D008875:Middle Aged; D010232:Paraffin; D010305:Parotid Diseases / Q000503:physiopathology; D010592:Pharmaceutic Aids; D010812:Physical Stimulation; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000503:physiopathology; D014987:Xerostomia / Q000145:classification / Q000503:physiopathology
chemical_list: D010592:Pharmaceutic Aids; D010232:Paraffin