Redox properties of benzocaine and its homologs.
Redox properties of the local anesthetic benzocaine and its homologs were studied by their reactions with free radical intermediates of dyes excited by the visible light. Homologs with more hydrophobic substituents at the benzene ring appeared to be better electron donors and facilitated photobleaching of the dye Methylene Blue or photoreduction of hemin. The electron-donor properties decreased in the same order as their blocking activities (C. Quan, W. M. Mok, and G. K. Wang, Biophys. J. 70:194-201 (1996)). This correlation is considered as additional evidence in favour of the ion channel redox model.
Marinov
B S
BS
Institute of Theoretical and Experimental Biophysics, Pushchino, Moscow Region, Russia.
Pozelueva
M M
MM
D000779:Anesthetics, Local / Q000737:chemistry*; D001566:Benzocaine / Q000031:analogs & derivatives / Q000737:chemistry*; D004396:Coloring Agents; D005609:Free Radicals; D006427:Hemin; D008751:Methylene Blue; D010084:Oxidation-Reduction; D010777:Photochemistry
D000779:Anesthetics, Local; D004396:Coloring Agents; D005609:Free Radicals; D006427:Hemin; D008751:Methylene Blue; D001566:Benzocaine