Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG.
The protective potential of killed Leishmania major (ALM) along with BCG was evaluated against L. donovani in Indian langur monkeys in single and triple dose schedules. A delayed protection was observed in monkeys after a single dose schedule of ALM (3 mg)+BCG (3 mg) given intradermally 2 months before intravenous challenge with L. donovani. Triple dose schedule each of 1 mg ALM + 1 mg BCG was more effective. The status remained unchanged until the end of the experiment (approximately 8 months). The study indicates that a combination of ALM + BCG may be a good candidate vaccine for exploiting against human Kala-azar.
Dube
A
A
Division of Parasitology, Central Drug Research Institute, Lucknow, India. root@cscdri.ren.nic.in
Sharma
P
P
Srivastava
J K
JK
Misra
A
A
Naik
S
S
Katiyar
J C
JC
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D002520:Cercopithecidae / Q000276:immunology / Q000469:parasitology*; D006224:Cricetinae; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D007194:India; D007893:Leishmania donovani / Q000276:immunology*; D018320:Leishmania major / Q000276:immunology; D007898:Leishmaniasis, Visceral / Q000517:prevention & control*; D008297:Male; D016052:Protozoan Vaccines / Q000008:administration & dosage; D013154:Spleen / Q000469:parasitology; D014611:Vaccination / Q000379:methods*; D015164:Vaccines, Inactivated / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D016052:Protozoan Vaccines; D015164:Vaccines, Inactivated