title: Central nervous system toxicity attributable to epidural ropivacaine hydrochloride.
abstract: Ropivacaine, a new local anaesthetic agent, has been demonstrated to have less potential than bupivacaine for central nervous system toxicity on the basis of human and animal studies. We report a case of a convulsion secondary to presumed inadvertent intravascular injection of 20 mg of ropivacaine in a 44 kg patient during an epidural for chronic pain. There were minimal signs of cardiovascular toxicity.
authors.affiliation: Department of Anaesthesia, Geelong Hospital, Geelong.
authors.forename: A N
authors.initials: AN
authors.lastname: Plowman
authors.forename: S
authors.initials: S
authors.lastname: Bolsin
authors.forename: L E
authors.initials: LE
authors.lastname: Mather
mesh_terms: D000293:Adolescent; D000577:Amides / Q000008:administration & dosage* / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D007268:Injections, Epidural; D008297:Male; D010148:Intractable Pain / Q000188:drug therapy; D000077212:Ropivacaine; D012640:Seizures / Q000139:chemically induced*
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine