Pharmacology of drug transfer across the placenta.
The effect of drugs in the fetus can be thought of in terms of the dose-response based on a knowledge of the general principles by which drug is transferred from the mother to the fetus. Fetal drug concentration, which determines the fetal response, is a function of the maternal concentration, the placental permeability, the fetal drug clearance, and differences in protein binding and ionization between the maternal and fetal plasma.
Garland
M
M
Department of Pediatrics, College of Physicians and Surgeons, Columbia Univesity, New York, New York, USA.
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D010599:Pharmacokinetics; D010920:Placenta / Q000502:physiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000503:physiopathology*