Mitochondrial abnormalities in selenium-deficient myopathy.
We report a man who developed selenium-deficient myopathy during long-term parenteral nutrition. Muscle biopsy showed marked mitochondrial depletion in the deep sarcoplasm and enlarged mitochondria at the periphery mainly in type 2 fibers. Muscle weakness improved gradually after the second course of selenium supplementation. The peculiar mitochondrial abnormalities in muscle fibers appear to play a key role in the pathogenesis of selenium-deficient myopathy.
Osaki
Y
Y
Department of Medicine and Geriatrics, Kochi Medical School, Nankoku-city, Kochi, Japan.
Nishino
I
I
Murakami
N
N
Matsubayashi
K
K
Tsuda
K
K
Yokoyama
Y I
YI
Morita
M
M
Onishi
S
S
Goto
Y I
YI
Nonaka
I
I
D000328:Adult; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000473:pathology*; D017240:Mitochondrial Myopathies / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D018908:Muscle Weakness / Q000188:drug therapy / Q000503:physiopathology; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D010288:Parenteral Nutrition / Q000009:adverse effects; D012643:Selenium / Q000172:deficiency* / Q000627:therapeutic use; D013997:Time Factors
D012643:Selenium