Embryotoxicity and teratogenicity of some derivatives of chloroethylaminophenylacetic acid.
Embryotoxic and teratogenic properties of Lophenal, Phenalon, Pharanox and Pharanoxi selenate were investigated experimentally. All examined antitumour agents showed embryotoxic effects. Lophenal, Phenalon and Pharanox had teratogenic effects. By modifying the structure of Pharanox with selenium a reduction in teratogenic effect was achieved.
Zalgeviciené
V
V
Vilnius University, Faculty of Medicine, Vilnius, Lithuania.
Zukiené
J
J
Grazeliené
G
G
Sinkeviciúté
G
G
Didziapetriené
J
J
D000015:Abnormalities, Multiple / Q000139:chemically induced*; D000085:Acetates / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000473:pathology; D016566:Organoselenium Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D010648:Phenylacetates / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013723:Teratogens / Q000737:chemistry / Q000633:toxicity*
D000085:Acetates; D000970:Antineoplastic Agents; D016566:Organoselenium Compounds; D010648:Phenylacetates; D013723:Teratogens; C113657:lophenal; C113659:pharanox; C113660:pharanoxi selenate; C113658:phenalon