Mitochondrial import: crossing the aqueous intermembrane space.
Mitochondrial protein import follows a general pathway for preproteins with amino-terminal presequences. The discovery of novel import components has now revealed a distinct pathway for translocation of hydrophobic proteins across the intermembrane space and into the inner membrane.
Pfanner
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Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Strasse 7, D-79104, Freiburg, Germany. pfanner@ruf.uni-freiburg.de
D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D002352:Carrier Proteins; D008565:Membrane Proteins; D011498:Protein Precursors