title: Imaging asynchronous mechanical activation of the paced heart with tagged MRI.
abstract: A method for imaging the rapid temporal-spatial evolution of myocardial deformations in the paced heart is proposed. High time resolution-tagged MR images were obtained after stimulation of the myocardium with an MR-compatible pacing system. The images were analyzed to reconstruct dynamic models of local 3D strains over the entire left ventricle during systole. Normal canine hearts were studied in vivo with pacing sites on the right atrium, left ventricular free wall and right ventricular apex. This method clearly resolved local variations in myocardial contraction patterns caused by ventricular pacing. Potential applications are noninvasive determination of electrical conduction abnormalities and the evaluation of new pacing therapies.
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: McVeigh
authors.forename: F W
authors.initials: FW
authors.lastname: Prinzen
authors.forename: B T
authors.initials: BT
authors.lastname: Wyman
authors.forename: J E
authors.initials: JE
authors.lastname: Tsitlik
authors.forename: H R
authors.initials: HR
authors.lastname: Halperin
authors.forename: W C
authors.initials: WC
authors.lastname: Hunter
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial; D004285:Dogs; D006325:Heart Atria / Q000473:pathology* / Q000503:physiopathology; D006329:Heart Conduction System / Q000473:pathology / Q000503:physiopathology; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009200:Myocardial Contraction