title: Peloisis hepatis due to Bartonella henselae in transplantation: a hemato-hepato-renal syndrome.
abstract: BACKGROUND
  Bacillary peliosis hepatis is an uncommon but well recognized disease due to disseminated Bartonella infections occurring predominantly in immunocompromised individuals infected with human immunodeficiency virus, type 1. A similar condition in the absence of Bartonella infection when described in organ transplant patients was felt to be secondary to azathioprine and/or cyclosporine.
  
  
  METHODS
  Herein, we report the first case of bacillary peliosis hepatis due to systemic Bartonella henselae infection in a patient after kidney transplant. The patient presented with severe anemia, persistent thrombocytopenia, and hepato-renal syndrome. DNA-based polymerase chain reactions (PCR), which allowed direct detection of both B henselae and quintana DNA in patient's peripheral blood and liver tissue, were used. Indirect immunofluorescence assay for Bartonella serology was performed on peripheral blood.
  
  
  RESULTS
  Histopathology of the liver biopsy demonstrated peliosis hepatis. Indirect immunofluorescence assay for Bartonella serology was positive, and B henselae DNA was identified by PCR in the peripheral blood and liver tissue. Treatment with a 3-month course of oral erythromycin resulted in an excellent clinical response.
  
  
  CONCLUSIONS
  The present case suggests that although various anti-rejection therapies and opportunistic infections are associated with hepatic and renal dysfunction along with bone marrow suppression, the diagnostic evaluation in this situation should include liver biopsy and a careful search for evidence of systemic Bartonella infection, e.g., exposure to cats, Bartonella serology, and Bartonella DNA by PCR. A reduction in immunosuppression and prolonged therapy with antibiotics such as erythromycin will often result in early recovery.
authors.affiliation: Department of Medicine, The Milton S. Hershey Medical Center, Pennsylvania State University, College of Medicine, Hershey 17033, USA.
authors.forename: N
authors.initials: N
authors.lastname: Ahsan
authors.forename: M J
authors.initials: MJ
authors.lastname: Holman
authors.forename: T R
authors.initials: TR
authors.lastname: Riley
authors.forename: C S
authors.initials: CS
authors.lastname: Abendroth
authors.forename: E G
authors.initials: EG
authors.lastname: Langhoff
authors.forename: H C
authors.initials: HC
authors.lastname: Yang
mesh_terms: D000328:Adult; D016917:Angiomatosis, Bacillary / Q000209:etiology / Q000382:microbiology*; D000818:Animals; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D018416:Bartonella henselae; D002415:Cats; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009894:Opportunistic Infections / Q000209:etiology / Q000382:microbiology; D010382:Peliosis Hepatis / Q000209:etiology / Q000382:microbiology*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D001379:Azathioprine