title: G-protein signaling: fine-tuning signaling kinetics.
abstract: Mammalian 'regulators of G protein signaling' (RGS proteins) help shut off G-protein-mediated signaling by GTPase activation. But new evidence shows that RGS proteins can also speed up the activation of signaling. The combined effect is a change in signaling kinetics without a decrease in signaling intensity.
authors.affiliation: Howard Hughes Medical Institute, Department of Physiology, University of California San Francisco, California 94143, USA. zerangue@phy.ucsf.edu
authors.forename: N
authors.initials: N
authors.lastname: Zerangue
authors.forename: L Y
authors.initials: LY
authors.lastname: Jan
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007473:Ion Channels; D019204:GTP-Binding Proteins