The influence of the milieu on the rate of neutralisation of herpes simplex virus 1.
The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a rabbit purified polyclonal antibody, may represent an unrecognised homeostatic mechanism where neutralising antibody is 'dilution-fast' under physiological conditions of transudation or pathological conditions of inflammation.
Bolt
C E
CE
Department of Infection, The Medical School, University of Birmingham, UK.
Davies
J A
JA
Randall
S
S
Skinner
G R
GR
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000276:immunology*; D006801:Humans; D009500:Neutralization Tests; D011817:Rabbits
D000914:Antibodies, Viral; D000956:Antigens, Viral