Association of apolipoprotein E polymorphism with lipoprotein glomerulopathy. Report of 2 cases with a new genotype and comparison of the relative frequencies of apolipoprotein E isoforms in lipoprotein glomerulopathy and in the general population.
Two cases of lipoprotein glomerulopathy with a new apolipoprotein E (Apo E) genotype, epsilon3/epsilon4, were diagnosed recently. These 2 cases, together with other cases documented in English literature made a total of 6 common isoforms of Apo E encountered in lipoprotein glomerulopathy. Although the calculated allele frequency of epsilon2 is relatively high in cases with lipoprotein glomerulopathy as compared with that in the general population (39.3 vs. 6.4-11.4%), the gradual emergence of Apo E isoforms other than E2/E3 in lipoprotein glomerulopathy implicates that the genetic susceptibility of certain Apo E isoforms may not be a crucial factor. An alteration in the local environment of glomerular capillaries may be more important in the pathogenesis of lipoprotein glomerulopathy.
Yang
A H
AH
Department of Pathology, Veterans General Hospital-Taipei, School of Medicine, National Yang-Ming University, Taiwan. ahyang@vghtpe.gov.tw
Ng
Y Y
YY
Tarng
D C
DC
Chen
J Y
JY
Shiao
M S
MS
Kao
J T
JT
D000328:Adult; D001057:Apolipoproteins E / Q000097:blood* / Q000235:genetics; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D005838:Genotype; D006801:Humans; D007536:Isomerism; D007674:Kidney Diseases / Q000097:blood* / Q000235:genetics; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E; D003404:Creatinine