Low intensities and 1.3 ratio produce distortion product otoacoustic emissions which are larger in heterozygous (+/dn) than homozygous (+/+) mice.
The f2/f1 frequency ratio of 1.3 in combination with stimulus levels of L1/L2 = 50/60 and 50/50 dB SPL produced a higher level of distortion product otoacoustic emissions (DPOAE) in the heterozygous (+/dn) mice than in the homozygous (+/+) mice. These results suggest that the dn gene carriers have a unique cochlear trait which may be related to the dn gene locus and expressed via a frequency- and intensity-dependent DPOAE function.
Huang
J M
JM
Department of Otorhinolaryngology and Biocommunication, Louisiana State University Medical Center, New Orleans 70112, USA.
Berlin
C I
CI
Lin
S T
ST
Keats
B J
BJ
D000161:Acoustic Stimulation; D000818:Animals; D003638:Deafness / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D051379:Mice; D017084:Otoacoustic Emissions, Spontaneous / Q000235:genetics*; D010641:Phenotype