title: Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment.
abstract: Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
authors.affiliation: Division of Neonatology, University Hospital, Lausanne, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Scalfaro
authors.forename: J J
authors.initials: JJ
authors.lastname: Chesaux
authors.forename: P A
authors.initials: PA
authors.lastname: Buchwalder
authors.forename: J
authors.initials: J
authors.lastname: Biollaz
authors.forename: J L
authors.initials: JL
authors.lastname: Micheli
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000378:metabolism; D000293:Adolescent; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D005260:Female; D006679:HIV Seropositivity / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008657:Metabolic Clearance Rate; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D015215:Zidovudine / Q000009:adverse effects* / Q000493:pharmacokinetics
chemical_list: D019380:Anti-HIV Agents; D015215:Zidovudine