title: Histopathological evaluation of the tissue reactions to Endo-Fill root canal sealant and filling material in rats.
abstract: In this in vivo study, the tissue reactions to silicone-based Endo-Fill root canal filling material were histopathologically evaluated. The reaction of rat connective tissue to polyethylene tube implants that were filled with Endo-Fill were evaluated at 2 days, at 1, 2, 4, and 8 weeks. Four tube were implanted in each rat subcutaneously, and a total of 15 rats were used. Rats were killed, and the specimens were examined under the light microscope (x115 and x230). At the end of 8 wk, a thin fibrous wall with an almost completed advanced healing process was observed around the implant material, but no capsule formation or any inflammatory infiltration was seen.
authors.affiliation: Department of Endodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
authors.forename: M O
authors.initials: MO
authors.lastname: Görduysus
authors.forename: I
authors.initials: I
authors.lastname: Etikan
authors.forename: A
authors.initials: A
authors.lastname: Gököz
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D008297:Male; D011095:Polyethylenes / Q000633:toxicity; D019736:Prostheses and Implants / Q000009:adverse effects; D011897:Random Allocation; D051381:Rats; D012387:Root Canal Filling Materials / Q000633:toxicity*; D013997:Time Factors
chemical_list: D011095:Polyethylenes; D012387:Root Canal Filling Materials; C074417:Endo-Fill