[Effect of temperature on Ca induced Ca release (CICR) rate].
The aim of this study is to assess the effect of temperature on CICR rate. The extensor digitorum longus muscles of male Hartley guinea pigs of about 450 g, were prepared for this study. According to Endo's method, CICR rates were measured using chemically skinned fibers. Two plates were prepared: one at 20 degrees C and the other at 30, 35, 37, 40 degrees C controlled by circulating water at an appropriate temperature placed underneath each plate. The whole procedure was carried out at 20 degrees C except the step of CICR using a plate at a given temperature. An increase in temperature (20 to 40 degrees C) accelerated CICR rate in a logarithmic manner. These experimental findings suggest that cooling of the patient's body is important not only to control metabolism but also to reduce an accelerated CICR rate.
Ichihara
Y
Y
First Department of Anesthesiology, Toho University School of Medicine, Tokyo.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D017679:Cryotherapy; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008305:Malignant Hyperthermia / Q000378:metabolism / Q000628:therapy*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D013696:Temperature
D002118:Calcium