title: Altered metabolic response of iron-depleted nonanemic women during a 15-km time trial.
abstract: In this double-blinded study, 37 women with iron depletion without anemia (age 19-36 yr) were randomly assigned to receive either an iron supplement (135 mg/day) or a placebo. Endurance capacity was assessed during a 15-km simulated time trial (TT) on a cycle ergometer before and after the 8-wk treatment. After the treatment, although the iron-supplemented group did not have shorter time to finish the TT (time), it had 2.0 kJ/min lower energy expenditure and 5.1% lower fractional utilization of peak oxygen consumption during the TT compared with the placebo group, after controlling for work rate (P < 0.05). Time, fractional utilization of peak oxygen consumption, and plasma lactate concentration at the 5th km of the TT were all negatively associated with hemoglobin levels, after controlling for work rate (P < 0.05). In conclusion, repletion of iron stores to women with iron depletion without anemia increased their energetic efficiency, and oxygen transport capacity of the blood was found to be an important determinant of endurance capacity and energy metabolism in nonanemic women.
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA. yizl@columbia.edu
authors.forename: Y I
authors.initials: YI
authors.lastname: Zhu
authors.forename: J D
authors.initials: JD
authors.lastname: Haas
mesh_terms: D000328:Adult; D000740:Anemia / Q000503:physiopathology; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000502:physiology; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000502:physiology; D016552:Ergometry; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007501:Iron / Q000032:analysis / Q000097:blood*; D019344:Lactic Acid / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D012123:Pulmonary Ventilation / Q000502:physiology; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D019344:Lactic Acid; D007501:Iron