title: Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene.
abstract: The Mas protooncogene is a maternally imprinted gene encoding an orphan G protein-coupled receptor expressed mainly in forebrain and testis. Here, we provide evidence for a function of Mas in the central nervous system. Targeted disruption of the Mas protooncogene leads to an increased durability of long term potentiation in the dentate gyrus, without affecting hippocampal morphology, basal synaptic transmission, and presynaptic function. In addition, Mas-/- mice show alterations in the onset of depotentiation. The permissive influence of Mas ablation on hippocampal synaptic plasticity is paralleled by behavioral changes. While spatial learning in the Morris water maze is not significantly influenced, Mas-deficient animals display an increased anxiety as assessed in the elevated-plus maze. Thus, Mas is an important modulating factor in the electrophysiology of the hippocampus and is involved in behavioral pathways in the adult brain.
authors.affiliation: Max-Delbrück-Center for Molecular Medicine (MDC), D-13122 Berlin-Buch, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Walther
authors.forename: D
authors.initials: D
authors.lastname: Balschun
authors.forename: J P
authors.initials: JP
authors.lastname: Voigt
authors.forename: H
authors.initials: H
authors.lastname: Fink
authors.forename: W
authors.initials: W
authors.lastname: Zuschratter
authors.forename: C
authors.initials: C
authors.lastname: Birchmeier
authors.forename: D
authors.initials: D
authors.lastname: Ganten
authors.forename: M
authors.initials: M
authors.lastname: Bader
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D018891:Dentate Gyrus / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D007173:Imprinting, Psychological; D017774:Long-Term Potentiation; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009473:Neuronal Plasticity; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000172:deficiency*; D043562:Receptors, G-Protein-Coupled
chemical_list: D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled