title: Effect of skeletonizing dissection on the internal thoracic artery.
abstract: BACKGROUND
  Skeletonization of the internal thoracic artery (ITA) produces greater length for coronary bypass grafting. We studied the effect of skeletonization on the morphology, histology, and tissue viability of the ITA wall.
  
  
  METHODS
  Six mongrel dogs underwent unilateral ITA dissection; the contralateral ITA was the control. Study periods were 3 weeks (n=3) and 12 weeks (n=3). At sacrifice, the entire anterior chest wall was removed and dynamically fixed with formalin. Extensive histologic comparisons were performed on three tissue blocks taken from each ITA, 2, 8, and 24 cm from their origin.
  
  
  RESULTS
  Flows at the end of the study were comparable to measurements taken during operation, immediately after skeletonization. Grossly, the ITA wall was not injured by skeletonization and there was no adventitial hematoma or bleeding from the sealed branch ends. Microscopic observations showed intact, normal wall structures. Histologic data showed no major significant difference between controls and skeletonized ITAs.
  
  
  CONCLUSIONS
  Careful skeletonizing dissection is not detrimental to the integrity of ITAs, which justifies their use for myocardial revascularization.
authors.affiliation: The Hope Heart Institute, Seattle, Washington 98122, USA.
authors.forename: T
authors.initials: T
authors.lastname: Sasajima
authors.forename: M H
authors.initials: MH
authors.lastname: Wu
authors.forename: Q
authors.initials: Q
authors.lastname: Shi
authors.forename: N
authors.initials: N
authors.lastname: Hayashida
authors.forename: L R
authors.initials: LR
authors.lastname: Sauvage
mesh_terms: D000818:Animals; D001026:Coronary Artery Bypass; D004210:Dissection / Q000379:methods*; D004285:Dogs; D004547:Elastic Tissue / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D005355:Fibrosis; D005404:Fixatives; D005557:Formaldehyde; D006085:Graft Survival; D006406:Hematoma / Q000473:pathology; D006470:Hemorrhage / Q000473:pathology; D008297:Male; D009336:Necrosis; D012039:Regional Blood Flow / Q000502:physiology; D013895:Thoracic Arteries / Q000473:pathology / Q000503:physiopathology / Q000601:surgery* / Q000637:transplantation; D013997:Time Factors; D016707:Tissue Fixation; D017540:Tunica Media / Q000473:pathology; D014654:Vascular Patency / Q000502:physiology
chemical_list: D005404:Fixatives; D005557:Formaldehyde