title: Reproducibility study of left ventricular measurements with breath-hold cine MRI using a semiautomated volumetric image analysis program.
abstract: The reproducibility of a semiautomated method of volumetric analysis allowing estimates of left ventricular (LV) parameters in approximately 5 minutes of analysis time is reported. Twenty normal volunteers underwent cine breath-hold cardiac MRI on two occasions with two observers using this new semiautomated method to estimate LV parameters. Reproducibility of this technique was comparable to published data with a variability of less than approximately 10% for all LV parameters calculated. Using this technique, the 95% confidence limits for change for left ventricular end diastolic volume (LVEDV) = +/-15 ml, left ventricular end systolic volume (LVESV) = +/-8 ml, LV mass = +/-24 g, and left ventricular ejection fraction (LVEF) = +/-6%. This new method also compared favorably to established manual methods. This new method permits estimation of LV parameters with acceptable reproducibility in a time that may permit routine quantitation of cardiac MR studies.
authors.affiliation: Division of Medical Imaging, St. George Hospital, Sydney, Australia.
authors.forename: S P
authors.initials: SP
authors.lastname: Butler
authors.forename: E
authors.initials: E
authors.lastname: McKay
authors.forename: A L
authors.initials: AL
authors.lastname: Paszkowski
authors.forename: R J
authors.initials: RJ
authors.lastname: Quinn
authors.forename: R C
authors.initials: RC
authors.lastname: Shnier
authors.forename: J T
authors.initials: JT
authors.lastname: Donovan
mesh_terms: D000328:Adult; D001331:Automation; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016014:Linear Models; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D016277:Ventricular Function, Left