title: (-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor.
authors.affiliation: Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Wishka
authors.forename: D R
authors.initials: DR
authors.lastname: Graber
authors.forename: L A
authors.initials: LA
authors.lastname: Kopta
authors.forename: R A
authors.initials: RA
authors.lastname: Olmsted
authors.forename: J M
authors.initials: JM
authors.lastname: Friis
authors.forename: J D
authors.initials: JD
authors.lastname: Hosley
authors.forename: W J
authors.initials: WJ
authors.lastname: Adams
authors.forename: E P
authors.initials: EP
authors.lastname: Seest
authors.forename: T M
authors.initials: TM
authors.lastname: Castle
authors.forename: L A
authors.initials: LA
authors.lastname: Dolak
authors.forename: B J
authors.initials: BJ
authors.lastname: Keiser
authors.forename: Y
authors.initials: Y
authors.lastname: Yagi
authors.forename: A
authors.initials: A
authors.lastname: Jeganathan
authors.forename: S T
authors.initials: ST
authors.lastname: Schlachter
authors.forename: M J
authors.initials: MJ
authors.lastname: Murphy
authors.forename: G J
authors.initials: GJ
authors.lastname: Cleek
authors.forename: R A
authors.initials: RA
authors.lastname: Nugent
authors.forename: S M
authors.initials: SM
authors.lastname: Poppe
authors.forename: S M
authors.initials: SM
authors.lastname: Swaney
authors.forename: F
authors.initials: F
authors.lastname: Han
authors.forename: W
authors.initials: W
authors.lastname: Watt
authors.forename: W L
authors.initials: WL
authors.lastname: White
authors.forename: T J
authors.initials: TJ
authors.lastname: Poel
authors.forename: R C
authors.initials: RC
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Morris
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D002460:Cell Line; D004352:Drug Resistance, Microbial; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009154:Mutation; D011725:Pyridines / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D019380:Anti-HIV Agents; D011725:Pyridines; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase; C111902:PNU 142721