title: Long-term clinical outcome following coronary artery bypass grafting for isolated stenosis of the left anterior descending coronary artery.
abstract: OBJECTIVE
  To detail the clinical and angiographic profile, and long-term outcome in consecutive patients with isolated stenosis of the left anterior descending coronary artery undergoing bypass surgery.
  
  
  METHODS
  A retrospective study of all patients (n = 301) (January 1984-December 1990) and undergoing coronary artery bypass grafting for isolated left anterior descending disease, in the Irish Republic, was performed. Survival was compared with that of an exact age- and gender-matched cohort.
  
  
  RESULTS
  Mean age was 53 (+/- 9.3) years. There were 238 (79%) males. In 241 (80%) patients an internal thoracic arterial bypass graft was used. Operative mortality was 1.3%. Of the 280 (93%) patients alive (16 cardiac deaths) at 7.1 (+/- 1.9) years, 105 (35%) had angina, 26 (9%) suffered an interval myocardial infarction, and repeat revascularization was required on 29 (10%). Female gender (P = 0.002), pre-operative myocardial infarction (P = 0.02), significant diagonal disease (P = 0.04) and postoperative myocardial infarction (P = 0.0001) were independently associated with survival. Females were more likely to develop congestive cardiac failure (P = 0.01) or postoperative angina (P = 0.03) than their male counterparts.
  
  
  CONCLUSIONS
  Survivorship (97%) and event-free survival (96%) at 5 years following coronary artery bypass grafting for isolated left anterior descending coronary artery disease is excellent and equivalent to an age-matched and gender-matched cohort.
authors.affiliation: Department of Clinical Cardiology, Mater Misericordiae Hospital (University College), Dublin, Ireland.
authors.forename: T G
authors.initials: TG
authors.lastname: Hennessy
authors.forename: M B
authors.initials: MB
authors.lastname: Codd
authors.forename: S
authors.initials: S
authors.lastname: Donnelly
authors.forename: C
authors.initials: C
authors.lastname: Hartigan
authors.forename: H A
authors.initials: HA
authors.lastname: McCann
authors.forename: C
authors.initials: C
authors.lastname: McCarthy
authors.forename: M
authors.initials: M
authors.lastname: Neligan
authors.forename: A E
authors.initials: AE
authors.lastname: Wood
authors.forename: D
authors.initials: D
authors.lastname: Luke
authors.forename: E
authors.initials: E
authors.lastname: McGovern
authors.forename: T
authors.initials: T
authors.lastname: Aherne
authors.forename: D D
authors.initials: DD
authors.lastname: Sugrue
mesh_terms: D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome