title: Associations between central obesity and indexes of hemostatic, carbohydrate and lipid metabolism. Results of a 1-year intervention from the Oslo Diet and Exercise Study.
abstract: The relationships of central obesity and physical fitness to indexes of hemostatic, lipid and glucose metabolism both at baseline and after 1 year of diet and exercise intervention were examined in 209 sedentary middle-aged men and women with increased coronary risk factor levels. Central obesity was measured as either waist circumference or waist/hip ratio. Maximal oxygen uptake was used as a measure of physical fitness. The cross-sectional results show that there were significant correlations between waist circumference and euglobuline clot lysis time (r = 0.23), factor VII (r = 0.16), glucose and insulin before and after 1 h glucose load (r ranging from 0.32 to 0.50). The 1-year intervention gave the following associations between changes in waist circumference and changes in: euglobuline clot lysis time (r = 0.27), factor VII (r = 0.19), carbohydrate variables and lipids (magnitude of r ranging from 0.19 to 0.43). Also the other indexes of obesity and physical fitness showed significant correlations to indexes of hemostatic, lipid and glucose variables, both cross-sectionally and for changes after the 1-year intervention. The associations between changes in central obesity and changes in indexes of hemostatic, carbohydrate and lipids were generally stronger during 1 year of diet and exercise intervention than those found at baseline. Multiple regression analyses with waist circumference, waist/hip ratio, percent body fat and Vo2 max as independent variables and indexes of hemostatic, carbohydrate and lipid metabolism as dependent variables showed that waist circumference was a significant predictor for indexes of the hemostatic, carbohydrate and lipid metabolism, mostly independent of physical fitness. The cross-sectional and 1-year change results support each other and therefore underscore the importance of abdominal obesity as an important risk factor for cardiovascular disease.
authors.affiliation: Department of Biology and Sports Medicine, Norwegian University of Sport and Physical Education, Oslo, Norway.
authors.forename: S A
authors.initials: SA
authors.lastname: Anderssen
authors.forename: I
authors.initials: I
authors.lastname: Holme
authors.forename: P
authors.initials: P
authors.lastname: Urdal
authors.forename: I
authors.initials: I
authors.lastname: Hjermann
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D001786:Blood Glucose / Q000032:analysis; D001824:Body Constitution; D015992:Body Mass Index; D003327:Coronary Disease / Q000209:etiology; D003430:Cross-Sectional Studies; D004038:Diet, Reducing; D005081:Exercise Therapy; D005167:Factor VII / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose / Q000378:metabolism*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000378:metabolism* / Q000628:therapy; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness; D012044:Regression Analysis; D012307:Risk Factors; D012712:Serum Globulins / Q000032:analysis
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012712:Serum Globulins; D005167:Factor VII; D005947:Glucose