[Nitric oxide in respiratory diseases].
Recent reports have described a pathogenic role of nitric oxide in several respiratory disease. It is specially useful in the adult respiratory distress syndrome, where it acts as a selective vasodilator and improves gas exchange, decreasing pulmonary shunting. Although it has a proven bronchodilator effect, its therapeutic role in diseases such as asthma and chronic limitation of airway flow is not well defined. This article review the metabolism, mechanisms of action, potential uses and adverse effects of nitric oxide in respiratory disease.
Andresen
M
M
Departamento de Medicina Interna y Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile.
Díaz
O
O
Troncoso
S
S
D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D006801:Humans; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D001993:Bronchodilator Agents; D014665:Vasodilator Agents; D009569:Nitric Oxide