title: Sweet's syndrome without granulocytosis.
abstract: BACKGROUND
  Sweet's syndrome (SS), acute febrile neutrophilic dermatosis, has been linked to hematologic malignancies and presents with characteristic edematous dermal plaques. Peripheral blood neutrophilia is frequently seen in association with SS and is one of the diagnostic criteria.
  
  
  OBJECTIVE
  To report the clinical, laboratory, and hematologic data of four patients with myeloid leukemia who developed SS after chemotherapy. Three of these patients were neutropenic.
  
  
  METHODS
  A retrospective study of four patients with SS and hematologic malignancies was undertaken. Three patients had de novo acute myelogenous leukemia and one was in the acute blast crisis of chronic myelogenous leukemia.
  
  
  RESULTS
  Sweet's syndrome was not originally suspected in these patients because of the low peripheral white blood cell counts caused by chemotherapy. All of the patients presented with fevers, arthralgias, and an eruption. They had been treated with antibiotics because of a presumed infection. Once the correct diagnosis was made and oral prednisolone was started, a rapid response followed.
  
  
  CONCLUSIONS
  Sweet's syndrome should be considered in the differential diagnosis when acute myeloid leukemic patients develop skin lesions and unexplained fevers regardless of the peripheral blood counts.
authors.affiliation: Pennsylvania State University College of Medicine, USA.
authors.forename: C
authors.initials: C
authors.lastname: Probert
authors.forename: W C
authors.initials: WC
authors.lastname: Ehmann
authors.forename: H
authors.initials: H
authors.lastname: al-Mondhiry
authors.forename: J
authors.initials: J
authors.lastname: Ballard
authors.forename: K F
authors.initials: KF
authors.lastname: Helm
mesh_terms: D000208:Acute Disease; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy; D007951:Leukemia, Myeloid / Q000150:complications / Q000188:drug therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology; D016463:Sweet Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000970:Antineoplastic Agents; D005938:Glucocorticoids; D011239:Prednisolone