[Risk factors for atherosclerosis in offspring of parents with primary hypertriglyceridemia].
High triglycerides and low fibrinolysis activity are considered as a significant predictors for atherosclerosis. The aim of our study was: 1-to compare these risk factors levels in children with positive family history of hypertriglyceridemia (HTG) with children from healthy families and 2-to assess the association between triglyceride and fibrinolysis activity in offspring (y) and parental risk factors (xl ... xn) for atherosclerosis. The study population consisted of: I Group 15 children 7-12 years old and their parents from HTG families and II Group 26 control children 5-12 years old from healthy families. Triglyceride (TG), total cholesterol, cholesterol esters, LDL-Ch, HDL-Ch, HDL2Ch, apolipoprotein AI and BII, fibrinogen plasma level were determined. Plasminogen activator inhibitor (PAI-1) and fibrinolysis activity and (ELT) were determined. We found significant differences in clinical examinations (higher blood pressure and ECG disturbances more frequently), HDL-Ch and HDL2-Ch plasma level was lower in children with positive family history than in control children. Multiple regression analysis of parental variables demonstrated, that children's TG and ELT are strongly determined by parental lipids and haemostasis parameters in children with positive family history of HTG.
Torbus-Lisiecka
B
B
Zakład Biochemii Klinicznej i Diagnostyki Laboratoryjnej Pomorskiej AM.
Jastrzebska
M
M
Szafrańska
B
B
Chełstowski
K
K
D000328:Adult; D001161:Arteriosclerosis / Q000235:genetics*; D002648:Child; D002784:Cholesterol / Q000097:blood; D004562:Electrocardiography; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics*; D016014:Linear Models; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D005340:Fibrinogen; D002784:Cholesterol