title: Effect of treatment on cyclosporine- and nifedipine-induced gingival enlargement: clinical and histologic results.
abstract: The clinical and histologic responses to periodontal treatment of gingival enlargements, induced when cyclosporine and nifedipine were administered singly or in combination, were evaluated. A significant correlation was noted between plaque, gingivitis, and gingival overgrowth. Severity of enlargement appeared to be greater in patients on combined therapy. All treatment approaches such as scaling, root planning, gingivectomy, and periodontal flaps, and a combination of therapies, were effective in the management of gingival overgrowth up to 1 year after completion of treatment. Adjunctive use of chlorhexidine was found to be beneficial.
authors.affiliation: Advanced Education Program in Periodontics, New York University College of Dentistry, New York, USA.
authors.forename: E
authors.initials: E
authors.lastname: Santi
authors.forename: M
authors.initials: M
authors.lastname: Bral
mesh_terms: D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D002710:Chlorhexidine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000009:adverse effects*; D012534:Dental Scaling; D004359:Drug Therapy, Combination; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy*; D005890:Gingivectomy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use; D009543:Nifedipine / Q000009:adverse effects*; D013524:Surgical Flaps; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D000891:Anti-Infective Agents, Local; D007166:Immunosuppressive Agents; D009067:Mouthwashes; D014665:Vasodilator Agents; D016572:Cyclosporine; D009543:Nifedipine; D002710:Chlorhexidine