Humoral immune response to p53 in malignant glioma.
p53 immunoreactivity and humoral immune response to p53 were examined in 14 patients with malignant glioma, including 4 patients with leptomeningeal glioma cell dissemination. Twelve patients expressed p53 protein within the tumour tissue. p53 antibodies were detected in the serum in 2 of 14 patients but never in the cerebrospinal fluid (CSF). Soluble p53 protein was detected neither in serum nor in CSF of the glioma patients. CSF levels of the immunosuppressive cytokine, transforming growth factor (TGF)-beta, were elevated in the glioma patients, including those with a humoral response to p53. These preliminary findings raise the possibility of systemic humoral immune responses to antigens, including mutant p53, expressed by glioma cells in the central nervous system.
Weller
M
M
Neurologische Klinik, Universität Tübingen, Germany. michael.weller@uni-tuebingen.de
Bornemann
A
A
Ständer
M
M
Schabet
M
M
Dichgans
J
J
Meyermann
R
R
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood* / Q000134:cerebrospinal fluid; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000378:metabolism; D005260:Female; D005910:Glioma / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000134:cerebrospinal fluid; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000276:immunology*
D001323:Autoantibodies; D016212:Transforming Growth Factor beta; D016159:Tumor Suppressor Protein p53