(-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor.
Wishka
D G
DG
Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
Graber
D R
DR
Kopta
L A
LA
Olmsted
R A
RA
Friis
J M
JM
Hosley
J D
JD
Adams
W J
WJ
Seest
E P
EP
Castle
T M
TM
Dolak
L A
LA
Keiser
B J
BJ
Yagi
Y
Y
Jeganathan
A
A
Schlachter
S T
ST
Murphy
M J
MJ
Cleek
G J
GJ
Nugent
R A
RA
Poppe
S M
SM
Swaney
S M
SM
Han
F
F
Watt
W
W
White
W L
WL
Poel
T J
TJ
Thomas
R C
RC
Morris
J
J
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D002460:Cell Line; D004352:Drug Resistance, Microbial; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009154:Mutation; D011725:Pyridines / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D011725:Pyridines; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase; C111902:PNU 142721