title: Lead concentrations in tibial and calcaneal bone in relation to the history of occupational lead exposure.
abstract: OBJECTIVE
  This study tested a simple model of the relationship between the lead concentration in bone (bone-Pb), exposure time, and lead in plasma (P-Pb) and whole blood (B-Pb) to make it possible to use bone-Pb as a retrospective exposure index.
  
  
  METHODS
  Seventy-seven active lead workers and 24 referents were studied. The bone-Pb in tibia (T-Pb) and calcaneus (C-Pb) was measured by in vivo X-ray fluorescence. P-Pb was calculated from B-Pb by use of the nonlinear relationship between these variables. Cumulative B-Pb (cumB-Pb) and P-Pb (cumP-Pb) were calculated to the time of the bone-Pb measurements. In addition, cumP-Pb was adjusted by applying varying rate constants for the transfer of lead from bone to plasma.
  
  
  RESULTS
  There were close linear associations between the lead concentrations in tibia (proportion of variance explained, R2 = 0.78) and calcaneus (R2 = 0.80), on one hand and the cumB-Pb on the other. The best fit of bone-Pb to the adjusted cumP-Pb (0.79 for T-Pb; 0.82 for C-Pb) was obtained for the terminal phase half-times of 13 and 12 years, respectively.
  
  
  CONCLUSIONS
  The combined data on bone-Pb and exposure time make it possible to estimate previous mean P-Pb and B-Pb. Such estimates will be valuable in studies of toxic effects on long-term exposed lead workers when data on the intensity of previous exposure are lacking. The use of P-Pb in modeling bone-Pb kinetics is physiologically relevant, but the use of adjusted cumP-Pb, as compared with cumB-Pb, did not significantly change the variance in the relation to bone-Pb.
authors.affiliation: Department of Occupational and Environmental Medicine, Lund University, University Hospital, Sweden.
authors.forename: I A
authors.initials: IA
authors.lastname: Bergdahl
authors.forename: U
authors.initials: U
authors.lastname: Strömberg
authors.forename: L
authors.initials: L
authors.lastname: Gerhardsson
authors.forename: A
authors.initials: A
authors.lastname: Schütz
authors.forename: D R
authors.initials: DR
authors.lastname: Chettle
authors.forename: S
authors.initials: S
authors.lastname: Skerfving
mesh_terms: D000293:Adolescent; D000328:Adult; D001842:Bone and Bones / Q000737:chemistry*; D002111:Calcaneus; D006207:Half-Life; D006801:Humans; D007854:Lead / Q000032:analysis / Q000097:blood* / Q000493:pharmacokinetics; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D008954:Models, Biological; D016273:Occupational Exposure; D013977:Tibia
chemical_list: D007854:Lead