title: Functional and ultrastructural evidence of myocardial stunning after acute carbon monoxide poisoning.
abstract: OBJECTIVE
  To study human myocardial ultrastructural changes after carbon monoxide (CO) poisoning inducing reversible cardiac failure.
  
  
  METHODS
  
  
  
  METHODS
  clinical, functional and morphologic findings.
  
  
  METHODS
  Public university-affiliated hospital and electron microscopy laboratory.
  
  
  METHODS
  A 25-yr-old woman with functional evidence of cardiac failure after acute CO poisoning.
  
  
  METHODS
  Hyperbaric and intensive care treatment over 10 days. Scintigraphic and cardiac angiography with endomyocardial biopsy.
  
  
  RESULTS
  Scintigraphy with 99mTc hexakis 2-methoxy-2-isobutyl isonitrile (sestaMIBI) showed an uptake defect in the left anterior descending artery territory. The cardiac angiography demonstrated a slight hypokinesis of the superior two thirds of the anterior wall and of the septal region with completely normal coronary angiograms. Electron microscopy of left ventricular biopsies showed slight ultrastructural changes in the myocytes. In addition, large glycogen deposits were mostly associated with swollen mitochondria. The patient was discharged in good clinical condition on day 10.
  
  
  CONCLUSIONS
  Presence of glycogen deposits associated with abnormal mitochondria may be signs of the incapability of myocardial cells in utilizing energy substrata. In the presence of normal myocardial perfusion, our findings are consistent with the presence of a stunned myocardium-like syndrome. Early recognition and treatment of this clinical syndrome allow the prevention of myocardial infarction.
authors.affiliation: Department of Anesthesia and Intensive Care, Faculty of Medicine, University of Rome La Sapienza, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Tritapepe
authors.forename: G
authors.initials: G
authors.lastname: Macchiarelli
authors.forename: M
authors.initials: M
authors.lastname: Rocco
authors.forename: F
authors.initials: F
authors.lastname: Scopinaro
authors.forename: O
authors.initials: O
authors.lastname: Schillaci
authors.forename: E
authors.initials: E
authors.lastname: Martuscelli
authors.forename: P M
authors.initials: PM
authors.lastname: Motta
mesh_terms: D000328:Adult; D002249:Carbon Monoxide Poisoning / Q000150:complications* / Q000628:therapy; D005260:Female; D006439:Hemodynamics; D006801:Humans; D017682:Myocardial Stunning / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D009206:Myocardium / Q000648:ultrastructure; D011877:Radionuclide Imaging