title: In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls.
abstract: We investigated cytokine levels (interleukin [IL]-1beta, IL-1ra, IL-2, IL-6, tumor necrosis factor [TNF]-alpha, TNF-beta) in plasma and secreted by mitogen-stimulated blood monocytes and lymphocytes; T-cell subsets; and natural killer cell activity in patients with narcolepsy and in human leukocyte antigen (HLA)-DR2 matched controls. The only significant finding was higher IL-6 secretion by monocytes of patients than by those of the HLA-DR2-positive controls. In conclusion, we found no major abnormalities of T-cell function in patients with narcolepsy, but slight alterations of monocyte function deserving further investigation.
authors.affiliation: Clinical Institute, Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Hinze-Selch
authors.forename: T C
authors.initials: TC
authors.lastname: Wetter
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: H C
authors.initials: HC
authors.lastname: Lu
authors.forename: E D
authors.initials: ED
authors.lastname: Albert
authors.forename: J
authors.initials: J
authors.lastname: Mullington
authors.forename: H
authors.initials: H
authors.lastname: Wekerle
authors.forename: F
authors.initials: F
authors.lastname: Holsboer
authors.forename: T
authors.initials: T
authors.lastname: Pollmächer
mesh_terms: D000328:Adult; D005260:Female; D015802:HLA-DR2 Antigen / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008233:Lymphotoxin-alpha / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000276:immunology*; D012795:Sialoglycoproteins / Q000378:metabolism; D012895:Sleep, REM / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015802:HLA-DR2 Antigen; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D008233:Lymphotoxin-alpha; D012795:Sialoglycoproteins; D014409:Tumor Necrosis Factor-alpha