Successful treatment of a staphylococcal endocarditis vegetation with tissue plasminogen activator.
A 930 gm premature infant had Staphylococcal endocarditis with a tricuspid valvular vegetation that was unresponsive to antibiotics and not amenable to resection. Infusion of tissue plasminogen activator over a 3-day period completely lysed the vegetation. The infection cleared with continued antibiotics, and the infant recovered without sequelae.
Fleming
R E
RE
Department of Pediatrics, St. Louis University School of Medicine, Missouri 63104, USA.
Barenkamp
S J
SJ
Jureidini
S B
SB
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010960:Plasminogen Activators / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator