title: Evaluation of SPf66 malaria vaccine efficacy in Brazil.
abstract: This paper reports the efficacy results of the randomized, placebo-controlled, field trial of SPf66 malaria vaccine in Costa Marques, Rondonia, Brazil. This region is characterized by the seasonal distribution of Plasmodium falciparum and P. vivax infections, and the recent occupation by migrants from nonendemic areas. A total of 800 individuals of both sexes, ranging in age from seven to 60 years, were included in the study. Of the initial cohort, 572 participants completed the vaccination schedule. Clinical and parasitologic evaluations were obtained by active and passive searches on a periodic basis. The overall protective efficacy against P. falciparum infections was -1.6% (-32.9% to 22.4%), and 14.1% (-17.0% to 36.9%) for the first episode. The overall protective efficacy for P. vivax infections was -19.7% (-44.8% to 1.03%), and -10.8% (-41.1% to 12.8%) for the first episode. No statistical evidence of an overall significant protective effect of SPf66 malaria vaccine against P. falciparum and P. vivax malaria was obtained in this trial.
authors.affiliation: Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Urdaneta
authors.forename: A
authors.initials: A
authors.lastname: Prata
authors.forename: C J
authors.initials: CJ
authors.lastname: Struchiner
authors.forename: C E
authors.initials: CE
authors.lastname: Tosta
authors.forename: P
authors.initials: P
authors.lastname: Tauil
authors.forename: M
authors.initials: M
authors.lastname: Boulos
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007115:Immunization Schedule; D017780:Malaria Vaccines / Q000009:adverse effects; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000517:prevention & control*; D016780:Malaria, Vivax / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged
chemical_list: D017780:Malaria Vaccines