A permanent pure amnestic syndrome of insidious onset related to Alzheimer's disease.
A 55-year-old patient experienced a pure amnestic syndrome of insidious onset that worsened progressively. Subsequently, her memory disorder stabilized and remained her only cognitive impairment for several years. She ultimately developed more widespread cognitive decline and terminal dementia. Postmortem examination 18 years after the onset revealed numerous senile plaques and neurofibrillary tangles consistent with Alzheimer's disease. A permanent pure amnestic syndrome of insidious onset may represent a further type of focal cerebral degeneration.
Didic
M
M
Laboratoire de Neurophysiologie et Neuropsychologie (INSERM CJF 9706), Faculté de Médecine, Marseilles, France.
Ali Chérif
A
A
Gambarelli
D
D
Poncet
M
M
Boudouresques
J
J
D000544:Alzheimer Disease; D000647:Amnesia / Q000473:pathology / Q000503:physiopathology / Q000523:psychology*; D001921:Brain / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007361:Intelligence Tests; D008568:Memory; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology; D058225:Plaque, Amyloid / Q000473:pathology; D013577:Syndrome; D013702:Temporal Lobe / Q000473:pathology; D013997:Time Factors; D014888:Wechsler Scales