Evaluation of two rapid hepatitis B surface antigen detection tests for screening in a blood bank.
The sensitivity and specificity of two rapid, low cost latex agglutination HBsAg detection tests were compared to a EIA HBsAg detection test using serum samples from 371 pregnant women in Kajiado, a rural Kenyan district. The sensitivity of the latex agglutination tests when compared to the EIA was 70.6% and 61.8%, while specificity was 92.0% and 85.2% respectively for the same tests. In view of their low sensitivity these rapid tests are not suitable for screening blood in district hospitals.
Verstraeten
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T
Kajiado District Hospital, Kenya.
Keya
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A
D001771:Blood Banks; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000517:prevention & control; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000592:standards; D007630:Kenya; D007841:Latex Fixation Tests / Q000592:standards*; D008403:Mass Screening / Q000379:methods*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000517:prevention & control; D015203:Reproducibility of Results; D012423:Rural Health; D012680:Sensitivity and Specificity
D006514:Hepatitis B Surface Antigens