title: MAO inhibitory side effects of neuroleptics and platelet serotonin content in schizophrenic patients.
abstract: In order to study the putative monoamine oxidase (MAO) inhibitory side effect of neuroleptics and simultaneous changes in platelet serotonin content both MAO-B activity and serotonin (5-HT) content in platelets of 30 healthy volunteers and 50 schizophrenic patients treated with neuroleptics were investigated. Our results have shown significantly lower MAO-B activity (15.26 +/- 6.81 S.D. vs. 8.63 +/- 3.82 mmol/hour/10(9) platelets) and higher platelet 5-HT content (906.19 +/- 285.33 vs. 1,727.85 +/- 947.40 ng/10(9) platelets) in the schizophrenic group. Platelet MAO-B activity was considerably lower in paranoid and residual schizophrenics compared with other patients, however, no difference was found in platelet 5-HT content between different subtypes of schizophrenia. Various neuroleptic treatments did not produce different effects either on platelet serotonin content or platelet MAO-B activity.
authors.affiliation: Department of Pharmacodynamics, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Mészáros
authors.forename: D
authors.initials: D
authors.lastname: Borcsiczky
authors.forename: M
authors.initials: M
authors.lastname: Máté
authors.forename: J
authors.initials: J
authors.lastname: Tarcali
authors.forename: K
authors.initials: K
authors.lastname: Tekes
authors.forename: K
authors.initials: K
authors.lastname: Magyar
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003024:Clozapine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008995:Monoamine Oxidase / Q000097:blood*; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D011336:Probability; D012016:Reference Values; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy*; D012701:Serotonin / Q000097:blood*
chemical_list: D014150:Antipsychotic Agents; D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D008995:Monoamine Oxidase; D003024:Clozapine; D006220:Haloperidol