title: Pro-epileptic changes in synaptic function can be accompanied by pro-epileptic changes in neuronal excitability.
abstract: Repetitive sensory input, stroboscopic lights or repeated sounds can induce epileptic seizures in susceptible individuals. In order to understand the process we have to consider multiple factors. The output of a set of neurones is determined by the amount of excitatory synaptic input, the degree of positive feedback and their inherent electrical excitability, which can be modified by synaptic inhibition. Recent research has shown that it is possible to separate these phenomena, and that they do not always behave in unison.
authors.affiliation: Neuroscience Research Group, School of Biological Sciences, University of Southampton, UK.
authors.forename: H V
authors.initials: HV
authors.lastname: Wheal
authors.forename: C
authors.initials: C
authors.lastname: Bernard
authors.forename: J E
authors.initials: JE
authors.lastname: Chad
authors.forename: R C
authors.initials: RC
authors.lastname: Cannon
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000166:cytology; D004827:Epilepsy / Q000503:physiopathology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D006801:Humans; D009475:Neurons, Afferent / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D014795:Visual Pathways / Q000166:cytology