[Dosimetry fundamentals of endovascular therapy using Re-188 for the prevention of restenosis after angioplasty].
OBJECTIVE
Various radionuclides can be used for endovascular brachytherapy. A new concept is to inflate the balloon of a dilatation catheter with a radioactive solution. Re-188 can be eluted from a generator system and is available daily. The aim of this study was to obtain dosimetric data for this radionuclide.


METHODS
The dose decrease of Re-188 was calculated and measured with a TLD-system radial to a balloon catheter typically used in cardiology (diameter: 3 mm, length: 20 mm).


RESULTS
Using a specific activity of 370 MBq/ml a dose of 0.3 Gy could be achieved within 1 min in a TLD in contact with the balloon. Paired TLDs differed about 3%. A fast dose reduction of 50% and 10% were stated within 0.5 mm and 2.5 mm, respectively. Calculated and measured values were in good agreement. The data are comparable to those known for Y-90.


CONCLUSIONS
Calculations of dose distribution are consistent with TLD measurements of Re-188. Using a specific activity of 1.85 GBq/ml, a dose of 10-15 Gy at the coronary artery wall can be achieved within 2-3 min. Compared to radioactive stents or wires the use of this liquid beta-emitter is a simple alternative for prevention of the restenosis following the angioplasty.
Kotzerke
J
J
Radiologie III (Nuklearmedizin), Universität Ulm, Germany.
Rentschler
M
M
Glatting
G
G
Schneider
E
E
Stabin
M
M
Knapp
F F
FF
Reske
S N
SN
D000800:Angioplasty, Balloon; D001918:Brachytherapy / Q000379:methods*; D002404:Catheterization; D003131:Combined Modality Therapy; D003327:Coronary Disease / Q000517:prevention & control / Q000532:radiotherapy / Q000628:therapy*; D004730:Endothelium, Vascular; D006801:Humans; D011868:Radioisotopes / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D012008:Recurrence; D012211:Rhenium / Q000627:therapeutic use*
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium