title: Effects of tetrodotoxin treatment in LGN on neuromodulatory receptor expression in developing visual cortex.
abstract: The expression and distribution patterns of transmitter receptors change dramatically during pre- and post-natal development of the visual cortex, but the factors that control these processes are largely unknown. We have tested the hypothesis that input activity from the lateral geniculate nucleus (LGN), one major input source to visual cortex, may contribute to the processes underlying transmitter receptor redistributions in the visual cortex during development. We found that a short period of tetrodotoxin (TTX) treatment in LGN retarded the developmental expression and age-dependent reorganization of neuromodulatory receptors, including muscarinic, serotonergic and adrenergic receptors, in kitten primary visual cortex. The visual cortices ipsilateral to the TTX infusion site displayed a 'younger' receptor pattern than that of their contralateral control counterparts in the same animals. The results suggest that active input from LGN regulates the expression profile of a broad range of receptors in the developing visual cortex.
authors.affiliation: Department of Ophthalmology, University of British Columbia, Vancouver, Canada. gu@ecc.ubc.ca
authors.forename: Q
authors.initials: Q
authors.lastname: Gu
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: R H
authors.initials: RH
authors.lastname: Dyck
authors.forename: V
authors.initials: V
authors.lastname: Booth
authors.forename: M S
authors.initials: MS
authors.lastname: Cynader
mesh_terms: D000818:Animals; D002415:Cats; D005829:Geniculate Bodies / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000096:biosynthesis*; D011976:Receptors, Muscarinic / Q000096:biosynthesis*; D011985:Receptors, Serotonin / Q000096:biosynthesis*; D013779:Tetrodotoxin / Q000494:pharmacology*; D014793:Visual Cortex / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
chemical_list: D011941:Receptors, Adrenergic; D011976:Receptors, Muscarinic; D011985:Receptors, Serotonin; D013779:Tetrodotoxin