Prostaglandin E2 downregulates inducible nitric oxide synthase expression in microglia by increasing cAMP levels.
Minghetti
L
L
Laboratory of Pathophysiology, Istituto Superiore di Sanità, Rome, Italy.
Nicolini
A
A
Polazzi
E
E
Créminon
C
C
Maclouf
J
J
Levi
G
G
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000201:enzymology*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D051546:Cyclooxygenase 2; D015232:Dinoprostone / Q000494:pharmacology*; D004790:Enzyme Induction; D007213:Indomethacin / Q000494:pharmacology; D007527:Isoenzymes / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology; D017628:Microglia / Q000187:drug effects / Q000201:enzymology*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D052247:Nitric Oxide Synthase Type II; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis; D051381:Rats
D007527:Isoenzymes; D008070:Lipopolysaccharides; D000242:Cyclic AMP; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone; D007213:Indomethacin