Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.).
Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O-beta-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of "akond mul" (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 micrograms/ml.
Kiuchi
F
F
Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
Fukao
Y
Y
Maruyama
T
T
Obata
T
T
Tanaka
M
M
Sasaki
T
T
Mikage
M
M
Haque
M E
ME
Tsuda
Y
Y
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018797:Cell Cycle Proteins; D004073:Digitoxigenin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010946:Plants, Medicinal; D000075383:S100 Calcium Binding Protein A6; D009418:S100 Proteins; D014407:Tumor Cells, Cultured / Q000187:drug effects
C111705:4'-O-glucopyranosylfrugoside; D000970:Antineoplastic Agents; D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; D005960:Glucosides; D000075383:S100 Calcium Binding Protein A6; D009418:S100 Proteins; C489133:S100A6 protein, Gallus gallus; D004073:Digitoxigenin; C025778:cannogenol-3-O-beta-D-allomethyloside