Complex traits and polygenic inheritance in the mouse.
Polygenic inheritance has recently become an increasingly active field of research due to the availability of techniques allowing in-depth screening of genetic markers across the entire genome. The mouse is being used both in its own right and as a model system for certain human traits. The advantages and disadvantages of the mouse for such studies are outlined and in this context, the adequacy of the mouse as a model for polygenic traits in humans is discussed. A detailed overview of the approaches and methods used in the analysis of polygenic inheritance in the mouse is presented.
Avner
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Unité de Génétique Moléculaire Murine, CNRS URA 1968, Institut Pasteur, Paris, France.
D000818:Animals; D001947:Breeding; D002874:Chromosome Mapping / Q000379:methods*; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D017422:Sequence Analysis, DNA