title: Feasibility and safety of beta irradiation in human coronary arteries.
abstract: We have developed a technique of endoluminally centred endovascular beta irradiation aimed at preventing restenosis after PTCA. The source consists of a pure metallic 90-Yttrium coil that can be positioned within the lumen at the target site by the use of a centering device and an afterloading console. Experimental evaluation of this approach showed that a dose of 18 Gy delivered at the inner arterial surface was highly effective in preventing fibrointimal hyperplasia in rabbit carotid and iliac arteries. A pilot clinical evaluation in the coronary arteries of 15 patients using the same dose demonstrated excellent feasibility and no unexpected side-effects. A dose-finding evaluation in the clinical setting is now planned.
authors.affiliation: Cardiology Center, University Hospital, Geneva, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Urban
authors.forename: V
authors.initials: V
authors.lastname: Verin
authors.forename: Y
authors.initials: Y
authors.lastname: Popowski
authors.forename: W
authors.initials: W
authors.lastname: Rutishauser
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D002339:Carotid Arteries / Q000528:radiation effects; D003327:Coronary Disease / Q000517:prevention & control* / Q000532:radiotherapy / Q000628:therapy; D003331:Coronary Vessels / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005240:Feasibility Studies; D005500:Follow-Up Studies; D006801:Humans; D007083:Iliac Artery / Q000528:radiation effects; D011817:Rabbits; D011835:Radiation Protection; D012008:Recurrence; D015607:Stents; D013997:Time Factors; D015021:Yttrium Radioisotopes / Q000008:administration & dosage*
chemical_list: D015021:Yttrium Radioisotopes