Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR-141716.
The present study assessed the efficacy of the cannabinoid CB1 receptor antagonist, SR-141716, in reducing voluntary ethanol intake in selectively bred Sardinian alcohol-preferring (sP) rats. Ethanol (10%, v/v) and food were available in daily 4 h scheduled access periods; water was present 24 h/day. The acute administration of a 2.5 and a 5 mg/kg dose of SR-141716 selectively reduced ethanol intake, whereas a 10 mg/kg dose of SR-141716 reduced to a similar extent both ethanol and food intake. These results suggest that the cannabinoid CB1 receptor is involved in the mediation of the ethanol-reinforcing effects in sP rats.
Colombo
G
G
C.N.R. Center for Neuropharmacology, University of Cagliari, Italy.
Agabio
R
R
Fà
M
M
Guano
L
L
Lobina
C
C
Loche
A
A
Reali
R
R
Gessa
G L
GL
D000428:Alcohol Drinking / Q000188:drug therapy* / Q000235:genetics / Q000523:psychology; D000818:Animals; D002186:Cannabinoids / Q000037:antagonists & inhibitors*; D002492:Central Nervous System Depressants / Q000097:blood; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000097:blood; D008297:Male; D010880:Piperidines / Q000627:therapeutic use*; D011720:Pyrazoles / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000037:antagonists & inhibitors; D000077285:Rimonabant
D002186:Cannabinoids; D002492:Central Nervous System Depressants; D010880:Piperidines; D011720:Pyrazoles; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D000431:Ethanol; D000077285:Rimonabant