title: Constant infusion rates of lipid emulsions to stabilize plasma triglyceride concentrations: medium-chain triglyceride/long-chain triglyceride emulsions (MCT/LCT) versus LCT.
abstract: As medium-chain triglyceride emulsions (MCT) are more rapidly hydrolyzed than long-chain triglyceride emulsions (LCT), MCT/LCT tends to be infused faster than LCT. The purpose of the present study was to determine the most appropriate infusion rate for MCT/LCT to stabilize plasma concentrations of triglyceride (TG), being equivalent to the optimal infusion rate of the emulsion. A TG clamp was set up by raising the mean +/- SD concentrations of TG in plasma, being 1.08 +/- 0.18 delta mmol l(-1) for LCT, and 1.65 +/- 0.31 delta mmol l(-1) for MCT/LCT after a 50-min priming infusion of each emulsion. Thereafter, the infusion rate of lipid was controlled every 10 min to maintain a steady concentration of TG for a period of 150 min. A constant infusion of glucose at 0.32 g/kg body weight (BW) per h was administered for the test period. The weight-based rate of the infusion to maintain a steady state of plasma TG concentrations did not differ between MCT/LCT and LCT, being 0.125 +/- 0.013 vs 0.117 +/- 0.021 g/kg BW per h, while the molar-based infusion rate was 0.203 +/- 0.021 mmol/kg BW per h for MCT/LCT and 0.132 +/- 0.023 mmol/kg BW per h for LCT (P < 0.05). These results suggest that although 54% more molar MCT/LCT-TG can be hydrolyzed during a constant infusion, MCT/LCT should not be infused at a rate faster than 0.1 g/kg BW per h under a steady state.
authors.affiliation: Second Department of Surgery, Mie University School of Medicine, Edobashi, Tsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iriyama
authors.forename: C
authors.initials: C
authors.lastname: Miki
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: N
authors.initials: N
authors.lastname: Kawarabayashi
authors.forename: H
authors.initials: H
authors.lastname: Urata
authors.forename: C
authors.initials: C
authors.lastname: Shigemori
mesh_terms: D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D006801:Humans; D006868:Hydrolysis; D008297:Male; D010288:Parenteral Nutrition / Q000379:methods; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D005217:Fat Emulsions, Intravenous; D014280:Triglycerides