Effect of nimodipine on the cognitive dysfunction induced by phenytoin and valproate in rats.
Anticonvulsant effects of phenytoin (PHT) and valproate (VPA) were studied alone and in combination with nimodipine (NMD) against maximal electroshock (MES)-induced seizures in rats. PHT and VPA induce cognitive deficit in terms of long-term memory loss. The effect of NMD on the cognitive deficit induced by PHT and VPA was studied through the step-through passive avoidance test (PAT). It was seen that there was a potentiation of antielectroshock effect of PHT and VPA when NMD at a dose of 4 mg/kg was combined with PHT or VPA. NMD reversed the long-term memory loss induced by PHT and VPA in the PAT.
Balakrishnan
S
S
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Pandhi
P
P
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D005260:Female; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D009553:Nimodipine / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects; D014635:Valproic Acid / Q000494:pharmacology*
D009553:Nimodipine; D014635:Valproic Acid; D010672:Phenytoin