Acute exacerbation of vasculitis during interferon-alpha therapy for hepatitis C-associated cryoglobulinaemia.
A significant, previously unreported, adverse reaction to interferon-alpha therapy is reported. Immediately after the commencement of low dose therapy a man with hepatitis-C associated cryoglobulinaemia developed a purpuric rash and a severe, reversible impairment of renal function. This observation may elucidate the immunopathogenesis of vasculitis.
Gordon
A C
AC
Department of Microbiology and Infectious Diseases, Nottingham City Hospital, UK.
Edgar
J D
JD
Finch
R G
RG
D000368:Aged; D003449:Cryoglobulinemia / Q000150:complications / Q000628:therapy*; D005076:Exanthema / Q000209:etiology; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D051437:Renal Insufficiency / Q000209:etiology; D014657:Vasculitis / Q000209:etiology* / Q000473:pathology
D016898:Interferon-alpha