Virilizing ovarian tumor of low malignant potential associated with antecedent tamoxifen use for breast cancer.
A patient is described who was treated with tamoxifen for breast cancer and developed an androgen-producing ovarian tumor of low malignant potential, which itself is a rare condition. Clinically overt virilism was leading to the diagnosis and promptly improved after surgical removal of the tumor. A causal relationship between tamoxifen use and the tumor is discussed on the basis of the known tumor-inducing potential of tamoxifen.
Surbek
D V
DV
Department of Obstetrics and Gynecology, University Hospital, Basel, Switzerland. surbek@ubaclu.unibas.ch
Hoesli
I
I
Torhorst
J
J
Almendral
A C
AC
Dellas
A
A
Holzgreve
W
W
D000728:Androgens / Q000096:biosynthesis / Q000097:blood; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000150:complications* / Q000473:pathology; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use; D014770:Virilism / Q000097:blood / Q000209:etiology*
D000728:Androgens; D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen