The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells.
This review focuses on the emerging body of literature suggesting a critical role for CD40/CD154 interactions in antigen-presenting cell (APC) activation, CD4+ and CD8+ T cell priming, and effector T cell maturation. In this context effective antigen presentation involves not only T cell expansion and long-term survival but also the ability of the APC to guide the T cell response toward the Th1 (interferon-gamma producing) or the Th2 (interleukin-4 producing) phenotype. We suggest a model to explain why CD40/CD154 interactions are critical for some helper and cytotoxic T cell responses, whereas others occur independently of this receptor/ligand pair. In addition, we will discuss the potential role for CD40/CD154 interactions in effector T cell maturation and cytokine production.
Mackey
M F
MF
Department of Microbiology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA.
Barth
R J
RJ
Noelle
R J
RJ
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism / Q000502:physiology*; D000951:Antigens, Neoplasm / Q000276:immunology; D019013:CD40 Antigens / Q000378:metabolism / Q000502:physiology*; D023201:CD40 Ligand; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D007108:Immune Tolerance; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism / Q000502:physiology*; D018417:Th1 Cells / Q000502:physiology; D018418:Th2 Cells / Q000502:physiology
D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D019013:CD40 Antigens; D008562:Membrane Glycoproteins; D023201:CD40 Ligand