Rotaviral antibodies in the treatment of acute rotaviral gastroenteritis.
The efficacy of hyperimmune bovine colostrum received from cows immunized with simian rotavirus SA11 in the treatment of rotavirus gastroenteritis was compared in a randomized double-blind trial to colostrum and ordinary milk preparations. One hundred and thirty-five children aged 6-30 months with rotaviral gastroenteritis received either hyperimmune bovine colostrum (n=42), ordinary colostrum (n=42) or milk (n=41) as a 100 ml solution four times/d for 4 d. Even though the differences were in favour of hyperimmune bovine colostrum in all the variables evaluated [greater weight gain (403 vs 343 g), shorter duration of diarrhoea (3.1 vs 3.6 d), fewer stools during 6 d (11.5 vs 13.6) and fewer stools during the first 3 d (9.3 vs 11.3)], all the differences were statistically insignificant. Differences of this size are clinically unimportant in well-nourished immunocompetent children, but we suggest that the hyperimmune bovine colostrum tested in our trial had some effects in the treatment of acute rotaviral gastroenteritis and should be evaluated further.
Ylitalo
S
S
Department of Paediatrics, University of Oulu, Finland.
Uhari
M
M
Rasi
S
S
Pudas
J
J
Leppäluoto
J
J
D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage* / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D002417:Cattle; D002675:Child, Preschool; D003126:Colostrum / Q000276:immunology*; D016001:Confidence Intervals; D004311:Double-Blind Method; D005260:Female; D005759:Gastroenteritis / Q000276:immunology / Q000628:therapy* / Q000821:virology; D006801:Humans; D007114:Immunization / Q000379:methods; D007223:Infant; D008297:Male; D008892:Milk / Q000276:immunology; D012016:Reference Values; D012400:Rotavirus Infections / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
D000914:Antibodies, Viral; D000956:Antigens, Viral; C094777:SA-11 antigen, Rotavirus