title: Glycosidopyrroles. Part 2. Acyclic derivatives: 1-(1,3-dihydroxy-2-propoxy)methylpyrroles as potential antiviral agents.
abstract: The series of 1-(1,3-dihydroxy-2-propoxy)methylpyrroles 2a-o were prepared in good overall yields according to Scheme I. When evaluated for antiviral activity against HIV-1, only compounds of the triphenyl series (R3 = NH2, N3, Br) were found to inhibit the HIV-1 replication at concentrations that were very not cytotoxic for MT-4 cells, with selectivity index 1.5-9.3. None of these compounds showed antibacterial or antifungal activity.
authors.affiliation: Istituto Farmacochimico, Università degli Studi, Palermo, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Almerico
authors.forename: P
authors.initials: P
authors.lastname: Diana
authors.forename: P
authors.initials: P
authors.lastname: Barraja
authors.forename: G
authors.initials: G
authors.lastname: Dattolo
authors.forename: F
authors.initials: F
authors.lastname: Mingoia
authors.forename: M
authors.initials: M
authors.lastname: Putzolu
authors.forename: G
authors.initials: G
authors.lastname: Perra
authors.forename: C
authors.initials: C
authors.lastname: Milia
authors.forename: C
authors.initials: C
authors.lastname: Musiu
authors.forename: M E
authors.initials: ME
authors.lastname: Marongiu
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D011758:Pyrroles