Familial dermatomyositis.
A case of familial dermatomyositis (DM) is reported in a 27-yr-old mother and her daughter aged 2 yr and 8 months. Familial DM is a rare occurrence and has never been reported in a child of < 4 yr old, although isolated cases of DM have been found in infants as young as 1 yr. The mother responded readily to corticosteroids; however, the child proved resistant to steroids and was eventually successfully managed on a combination of methotrexate and prednisolone. Another daughter presented with the dermatological stigmata of DM, but with no evidence of muscle involvement.
Andrews
A
A
Rheumatology Department, Mount Gould Hospital, Plymouth.
Hickling
P
P
Hutton
C
C
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003882:Dermatomyositis / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D004359:Drug Therapy, Combination; D005192:Family Health; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D011239:Prednisolone; D008727:Methotrexate