Cigarette smoking and cervical dysplasia among non-Hispanic black women.
This is the first case-control study to determine whether smoking is associated with cervical dysplasia, after adjustment for human papillomavirus (HPV) infection, among a group of non-Hispanic black women. Subjects were interviewed and asked questions about smoking and other risk factors for cervical cancer. HPV infection was determined by hybrid capture. Thirty-two women with histologically confirmed incident dysplasia and 113 control women with normal cytologic smears were enrolled; all women were HIV negative. Smoking was more strongly associated with dysplasia among women with high-grade lesions than among all case women combined. After adjustment, women with high-grade lesions were roughly four times more likely to be ever (odds ratio [OR]: 3.8; 95% confidence interval [CI]: 0.76-18.4) or current (OR: 4.3; 95% CI: 0.83-21.9) smokers, compared with control women. Larger studies among black women that control for HPV infection are needed to confirm these findings and to explore associations among black women with low-grade lesions.
Kanetsky
P A
PA
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Gammon
M D
MD
Mandelblatt
J
J
Zhang
Z F
ZF
Ramsey
E
E
Wright
T C
TC
Thomas
L
L
Matseoane
S
S
Lazaro
N
N
Felton
H T
HT
Sachdev
R K
RK
Richart
R M
RM
Curtin
J P
JP
D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009518:New York / Q000453:epidemiology; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000209:etiology*