title: Synthesis and in vitro and in vivo evaluation of dopaminergic ergoline derivatives.
abstract: A series of ergoline-amides was synthesised in the discovery of new dopaminomimetic agents. Several compounds exhibited in vivo high prolactin lowering activity (indirectly measured by the nidation test) in rats. For the most active, the potential anti-Parkinson activity was evaluated by observation of the contralateral turning behaviour in 6-OH-DA lesioned rats. The acute toxicity by oral route in mice was also studied.
authors.affiliation: Pharmacia and Upjohn-CNS Research, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Mantegani
authors.forename: E
authors.initials: E
authors.lastname: Brambilla
authors.forename: C
authors.initials: C
authors.lastname: Caccia
authors.forename: E
authors.initials: E
authors.lastname: Di Salle
authors.forename: M A
authors.initials: MA
authors.lastname: Cervini
authors.forename: R A
authors.initials: RA
authors.lastname: McArthur
authors.forename: G
authors.initials: G
authors.lastname: Traquandi
authors.forename: M
authors.initials: M
authors.lastname: Varasi
mesh_terms: D000818:Animals; D000978:Antiparkinson Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D004873:Ergolines / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D000978:Antiparkinson Agents; D004873:Ergolines