Evaluation of cardiovascular parameters by continuous 24 hour monitoring in diabetic hypertensive patients with autonomic neuropathies.
Correlations between scores of autonomic neuropathy severity in diabetic hypertensive subjects and behaviour of cardiovascular parameters detected by continuous 24 hour monitoring were investigated in order to reveal any alterations hat indicated onset and progression of disautonomy. R-R and Q-T patterns, circadian pressure rhythm and ECG Holter over 24 hours were analysed in 30 patients divided into various groups (age, duration of disease, treatment) and 10 controls. Three autonomic tests (deep breathing, postural hypotension, lying to standing) were performed and the relative Ewing scores recorded. Data obtained were analysed using Pearson's correlation test and simple linear regression. The results not only confirm circadian rhythm demodulation of arterial pressure, but also show progressive correlation between the scores obtained and modified cardiovascular parameters. According to the authors, detection of these intermediate alterations may be useful in forecasting possible onset or evolution of dysautonomic pathologies.
Scuderi
R
R
Istituto di Medicina Interna e Medicina D'Urgenza, Catania, Italy.
Viglianisi
F G
FG
Landolina
C
C
Privitera
P P
PP
Sfogliano
L
L
Noto
R
R
D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000503:physiopathology*; D018660:Blood Pressure Monitoring, Ambulatory; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D007004:Hypoglycemic Agents; D007328:Insulin