title: New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity: taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities.
abstract: Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activity when tested against a panel of other microorganisms.
authors.affiliation: Central Research Division, Pfizer Pharmaceuticals Inc., Aichi, Japan.
authors.forename: K A
authors.initials: KA
authors.lastname: Dekker
authors.forename: T
authors.initials: T
authors.lastname: Inagaki
authors.forename: T D
authors.initials: TD
authors.lastname: Gootz
authors.forename: L H
authors.initials: LH
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: W E
authors.initials: WE
authors.lastname: Kohlbrenner
authors.forename: Y
authors.initials: Y
authors.lastname: Matsunaga
authors.forename: P R
authors.initials: PR
authors.lastname: McGuirk
authors.forename: E
authors.initials: E
authors.lastname: Nomura
authors.forename: T
authors.initials: T
authors.lastname: Sakakibara
authors.forename: S
authors.initials: S
authors.lastname: Sakemi
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: N
authors.initials: N
authors.lastname: Kojima
mesh_terms: D042462:4-Quinolones; D000191:Actinomycetaceae; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents