Lack of involvement of known oncogenic DNA viruses in Epstein-Barr virus-negative Hodgkin's disease.
Epstein-Barr virus (EBV) is associated with around one-third of cases, but young adult cases are rarely EBV associated. In this study, known oncogenic DNA viruses, including human adenoviruses, papovaviruses and the human herpesviruses-6 (HHV-6) and -8 (HHV-8) were not detected in Hodgkin's disease lesions. These results suggest that an as yet unidentified infectious agent is involved in the pathogenesis of non-EBV-associated Hodgkin's disease.
Armstrong
A A
AA
LRF Virus Centre, University of Glasgow, UK.
Shield
L
L
Gallagher
A
A
Jarrett
R F
RF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D004267:DNA Viruses / Q000235:genetics / Q000302:isolation & purification*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009858:Oncogenic Viruses / Q000235:genetics / Q000302:isolation & purification*
D004279:DNA, Viral