Developmental changes in distribution patterns of phencyclidine-induced c-Fos in rat forebrain.
In the forebrain of 56-day-old rats, histochemical studies revealed that the subcutaneous injection of a psychotomimetic phencyclidine (PCP; 1 and 10 mg/kg) induced a dose-related and dense nuclear c-Fos-like immunoreactivity in the pyriform cortex, layers IV-VI of the neocortex and septum, but a sparse c-Fos immunostaining in the olfactory tubercle and mid-lateral striatum. Infant rats at postnatal day 8 expressed much fewer and more confined c-Fos-positive cells in the neocortex than young adult rats following PCP injection. However, a similar expression pattern of PCP-induced c-Fos was observed in the pyriform cortex, mid-lateral striatum, olfactory tubercle and septum between the infant and adult periods. These developmental changes in the regional distribution of a neuronal activity marker, c-Fos, suggest that neuronal populations involved in PCP-induced abnormal behavior are influenced by postnatal development, at least, in the neocortex.
Sato
D
D
Department of Mental Disorder Research, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Umino
A
A
Kaneda
K
K
Takigawa
M
M
Nishikawa
T
T
D000818:Animals; D000831:Animals, Newborn; D006213:Hallucinogens / Q000494:pharmacology*; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010622:Phencyclidine / Q000494:pharmacology*; D016548:Prosencephalon / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar
D006213:Hallucinogens; D009419:Nerve Tissue Proteins; D016760:Proto-Oncogene Proteins c-fos; D010622:Phencyclidine