title: Population distribution of alcohol dehydrogenase class I in France: comparison with other populations, and distribution with respect to gender and age. The French Group for Research on Alcohol and Liver.
abstract: In Caucasians, a genetic polymorphism is known for some alcohol dehydrogenase (ADH) systems (beta and gamma). Knowledge of population frequencies of the beta and gamma hepatic isozyme variants in France is a prerequisite to understanding any role this genetic variation might play in determining the risk of alcohol-related diseases. For the present study, the ADH phenotypes of 115 French Caucasian control subjects, consisting of 64 men and 51 women, were studied. The beta2 subunit was found to have a very low frequency. The relative frequencies of ADH gamma subunits observed in French Caucasians were found to be in good agreement with those already observed in other Caucasian populations. When gender and age were taken into account, a particular group corresponding to young men (age <50 years) was characterized by a manifest discordance with the comparable female population.
authors.affiliation: Université Victor Segalen Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Coutelle
authors.forename: P J
authors.initials: PJ
authors.lastname: Ward
authors.forename: P
authors.initials: P
authors.lastname: Quattrocchi
authors.forename: B
authors.initials: B
authors.lastname: Fleury
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000428:Alcohol Drinking / Q000453:epidemiology*; D000483:Alleles; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011153:Population; D012737:Sex Factors
chemical_list: D007527:Isoenzymes; D000426:Alcohol Dehydrogenase