Changes in presynaptic protein NACP/alpha-synuclein in an ischemic gerbil hippocampus.
We observed temporal changes in NACP (precursor protein of non-Abeta component of Alzheimer's disease amyloid), a presynaptic protein a.k. a. alpha-synuclein, in the hippocampus after 5 min ischemia. Intense NACP immunoreactivity was seen transiently around cerebral blood vessels in the CA1 subfield on day 4, and NACP-positive unusual tubal and chain-like structures developed on month 6. We suggest that the changes in NACP may play an important role in the ischemic pathogenesis.
Ishimaru
H
H
Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, Maebashi-shi, Gunma 371, Japan. ishimaru@news.sb.gunma-u.ac.jp
Uéda
K
K
Takahashi
A
A
Maruyama
Y
Y
D000682:Amyloid / Q000378:metabolism*; D000818:Animals; D005849:Gerbillinae; D006624:Hippocampus / Q000098:blood supply / Q000378:metabolism*; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D051843:Synucleins; D051844:alpha-Synuclein
D000682:Amyloid; D009419:Nerve Tissue Proteins; D011498:Protein Precursors; D051843:Synucleins; D051844:alpha-Synuclein