Oxidative modifications in nitrosative stress.
The molecular basis of redox sensitivity in proteins is not well understood. Here we consider a continuum of NO- and O2-related modifications of cysteine residues that constitute biological signaling events on the one hand and hallmarks of nitrosative and oxidative stresses on the other.
Stamler
J S
JS
Hausladen
A
A
D003545:Cysteine; D005978:Glutathione / Q000031:analogs & derivatives / Q000494:pharmacology; D005980:Glutathione Reductase / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide; D009603:Nitroso Compounds / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010100:Oxygen; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry*; D026422:S-Nitrosoglutathione
D009603:Nitroso Compounds; D011506:Proteins; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione; D005980:Glutathione Reductase; D005978:Glutathione; D003545:Cysteine; D010100:Oxygen