Protection against developmental deficiencies by a lipophilic VIP analogue.
Stearyl-Nle-VIP (SNV) is a novel agonist of vasoactive intestinal peptide (VIP) exhibiting a 100-fold greater potency than the parent molecule and specificity for a receptor associated with neuronal survival. Here, the developmental and protective effects of SNV were investigated in vivo using two models of developmental retardation, hypoxia and cholinergic blockade. In both cases chronic administration of SNV during development provided protective effects. Water maze experiments on the weaned animals have demonstrated a prophylactic action for SNV and enhancement of spatial memory in animals exposed to a cholinotoxin. SNV may act by providing neuroprotection, thereby improving cognitive functions. This work is dedicated to Prof. R.J. Wurtman whose inspiration and leadership in the field of neuroscience and cognition is beyond comparison.
Gozes
I
I
Dept. Clin. Biochem. Sackler Med. Sch. Tel Aviv Univ., Israel. igozes@post.tau.ac.il
Bachar
M
M
Bardea
A
A
Davidson
A
A
Rubinraut
S
S
Fridkin
M
M
D000375:Aging / Q000502:physiology / Q000523:psychology; D000818:Animals; D001388:Aziridines; D002794:Choline / Q000031:analogs & derivatives; D000860:Hypoxia; D008607:Intellectual Disability / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D008568:Memory / Q000187:drug effects / Q000502:physiology; D009466:Neuromuscular Blocking Agents; D009498:Neurotoxins; D051381:Rats; D013028:Space Perception / Q000187:drug effects / Q000502:physiology; D014660:Vasoactive Intestinal Peptide / Q000031:analogs & derivatives / Q000494:pharmacology*
D001388:Aziridines; D009466:Neuromuscular Blocking Agents; D009498:Neurotoxins; C086770:stearyl-norleucine(17)-vasoactive intestinal peptide; D014660:Vasoactive Intestinal Peptide; C044894:ethylcholine aziridinium; D002794:Choline