Calcium dobesilate increased endothelium-dependent relaxation in isolated rabbit aorta.
1. The aim of this study was to investigate the effects of calcium dobesilate on relaxant and contractile responses in the isolated rabbit aorta. 2. Calcium dobesilate (10(-6) and 10(-4) M) shifted the concentration-response curve induced by noradrenaline (10(-8)-10(-4) M) downward and to the right, the IC50 being 5.1 +/- 1.1 x 10(-7) M in the control and 7.5 +/- 1.2 x 10(-6) M and 3.1 +/- 1.9 x 10(-6) M in the presence of calcium dobesilate, 10(-6) M and 10(-4) M respectively. 3. Calcium dobesilate, 10(-5) M, increased the endothelium-dependent relaxation induced by acetylcholine (10(-8)-10(-5) M) but had no actions in the absence of endothelium.
Ruiz
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E
Department of Pharmacology, School of Medicine, Complutense University, Madrid, Spain.
Tejerina
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T
D000818:Animals; D001011:Aorta / Q000187:drug effects; D002123:Calcium Dobesilate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D006490:Hemostatics / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010396:Penicillamine / Q000031:analogs & derivatives / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
D006490:Hemostatics; C110881:S-nitro-N-acetylpenicillamine; D014662:Vasoconstrictor Agents; D012701:Serotonin; D002123:Calcium Dobesilate; D011189:Potassium Chloride; D006632:Histamine; D010396:Penicillamine; D009638:Norepinephrine