Evaluation of recombinant bovine somatotropin in the treatment of ovine pregnancy toxaemia.
Forty multigravid ewes with naturally-occurring ovine pregnancy toxaemia were treated with a concentrated oral dextrose and electrolyte solution administered three times daily an oral and a single subcutaneous injection of either a slow release formulation of 160mg recombinant bovine somatotropin (n = 17) or placebo injection (n = 23). A higher recovery rate was achieved in ewes treated with 160mg recombinant bovine somatotropin compared with controls (58.8 versus 34.8%, respectively), and more lambs were born alive and survived to 24th from treated ewes (15 of 46 lambs; 32.6%) compared with control ewes (12 of 62 lambs; 19.4%) but the treatment effects were not significantly different from the control group (P > 0.05).
Scott
P R
PR
Department of Veterinary Clinical Studies, Scotland, UK.
Sargison
N D
ND
Penny
C D
CD
D000818:Animals; D002417:Cattle; D004573:Electrolytes / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D013006:Growth Hormone / Q000627:therapeutic use*; D008098:Litter Size; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000628:therapy / Q000662:veterinary*; D011247:Pregnancy; D011994:Recombinant Proteins / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases
D004573:Electrolytes; D011994:Recombinant Proteins; D013006:Growth Hormone; D005947:Glucose