Ultradian rhythms in hydromineral hormones.
The maintenance of hydromineral homeostasis depends on the coordinated action of arginine vasopressin (AVP), atrial natriuretic peptide (ANP), the renin-angiotensin-aldosterone system and other recently identified endocrine or paracrine hormones. Several reports have pointed out the changes in urinary excretion and osmolality during the sleep-wake cycle and the rapid eye movement (REM)-non(N)REM sleep cycles. No such changes occur for ANP levels which have a flat profile over 24 h. The pulsatile fluctuations of AVP are described as random. The ultradian rhythm of plasma renin activity (PRA) depends on the regularity of the REM-NREM sleep cycles and the nocturnal curves reflect all disturbances in the internal sleep structure. A study with a shift in the normal sleep time clearly demonstrated that both PRA and aldosterone oscillations are sleep-stage dependent. These hormones could account for the ultradian variations in renal function. The nocturnal oscillations in sympathovagal balance may play an additional role. It is suggested that a central generator synchronizes endocrine, renal, autonomic and sleep processes.
Brandenberger
G
G
JE 2105, Faculté de Médecine, Strasbourg, France.
Charloux
A
A
Gronfier
C
C
Otzenberger
H
H
D000204:Activity Cycles / Q000502:physiology*; D004231:Diuresis / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D009318:Natriuresis / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology*
D006728:Hormones