Timed kill kinetic studies of levofloxacin, ofloxacin, and ciprofloxacin against Moraxella catarrhalis.
Levofloxacin bactericidal activity was compared to ciprofloxacin and ofloxacin against 10 strains of Moraxella catarrhalis. The cidal action (by kill-curve analysis) was slightly more rapid for levofloxacin, but all tested fluoroquinolones were considered bactericidal for all strains tested, including those producing BRO-1 and 2 beta-lactamases.
Barrett
M S
MS
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA.
Jones
R N
RN
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D006801:Humans; D064704:Levofloxacin; D001936:Moraxella catarrhalis / Q000187:drug effects*; D009346:Neisseriaceae / Q000187:drug effects*; D015242:Ofloxacin / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D013997:Time Factors
D000890:Anti-Infective Agents; D010879:Piperazines; D002939:Ciprofloxacin; D064704:Levofloxacin; D015242:Ofloxacin