The skin sensitization potential of four alkylalkanolamines.
The skin sensitization potential of 4 alkylalkanolamines (N-methylethanolamine, N,N-dimethylethanolamine, N-methyldiethanolamine and N,N-diethylethanolamine), was evaluated in a guinea pig maximation procedure by the method of Magnusson and Kligman. While all 4 alkylalkanolamines tested were irritating to the guinea pig skin, only N-methylethanolamine showed potential to induce allergic contact dermatitis. None of the remaining 3 alkylalkanolamines exhibited clear skin responses suggestive of sensitization.
Leung
H W
HW
Applied Toxicology Group, Union Carbide Corporation, Danbury, Connecticut 06817, USA.
Blaszcak
D L
DL
D000818:Animals; D003642:Deanol / Q000633:toxicity; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004983:Ethanolamines / Q000633:toxicity*; D005260:Female; D006168:Guinea Pigs; D007509:Irritants / Q000633:toxicity*; D008297:Male; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests
D004983:Ethanolamines; D007509:Irritants; D003642:Deanol; C008430:N-methyldiethanolamine; C007369:2-diethylaminoethanol; C017500:N-methylaminoethanol