title: Scrub typhus associated with multiorgan failure: a case report.
abstract: The spectrum of clinical severity for scrub typhus ranges from inapparent, mild, to severe or fatal. The pathologic changes are focal or disseminated multiorgan vasculitis of the small blood vessels, a fact that helps explain the great diversity of clinical manifestations that can be encountered. We reported a case of scrub typhus with unusual and serious multiorgan involvement, including tubulointerstitial nephritis (TIN) with acute renal failure (ARF), interstitial pneumonitis with adult respiratory distress syndrome (ARDS), disseminated intravascular coagulation (DIC), liver function impairment, upper gastrointestinal bleeding, prolonged hyperamylasaemia and hyperlipasaemia. Chloramphenicol administration rapidly altered the clinical course, but with sequelae of renal impairment and prolonged hyperamylasaemia and hyperlipasaemia for 10 months.
authors.affiliation: Department of Internal Medicine, Yuan's General Hospital, Kaohsiung, Taiwan.
authors.forename: W C
authors.initials: WC
authors.lastname: Chi
authors.forename: J J
authors.initials: JJ
authors.lastname: Huang
authors.forename: J M
authors.initials: JM
authors.lastname: Sung
authors.forename: R R
authors.initials: RR
authors.lastname: Lan
authors.forename: W C
authors.initials: WC
authors.lastname: Ko
authors.forename: F F
authors.initials: FF
authors.lastname: Chen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D002701:Chloramphenicol / Q000627:therapeutic use; D005335:Fever of Unknown Origin / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000382:microbiology*; D012285:Orientia tsutsugamushi / Q000276:immunology; D012612:Scrub Typhus / Q000150:complications* / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D002701:Chloramphenicol