title: Familial Mediterranean fever: the genetics of inflammation.
abstract: When a patient complains of episodic fever accompanied by unexplained arthritis, peritonitis, pleurisy, or skin rash, this disorder should be considered. The disease-related gene codes for a protein that guides a neutrophil's participation in inflammation; the protein's existence implies an entire regulatory pathway hitherto unknown. At least two other mendelian periodic fever syndromes have also been described.
authors.affiliation: National Institutes of Health, Bethesda, Md., USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Kastner
mesh_terms: D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D003937:Diagnosis, Differential; D010505:Familial Mediterranean Fever / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology*; D018703:Founder Effect; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007249:Inflammation; D018895:Microsatellite Repeats / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D018375:Neutrophil Activation / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic
chemical_list: D004247:DNA