A cellular anti-apoptosis protein is cleaved by the HIV-1 protease.
Cleavage of non-viral proteins is rarely observed with the HIV-1 protease (HIV pr). One such cleavage event occurs with bcl-2, an important cytoprotective protein. The loss of bcl-2 has biological consequences, leading to enhanced HIV replication and programmed death of the host cell. A strategy is proposed to suppress HIV with non-cleavable mutants of bcl-2.
Korant
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BD
DuPont Merck Pharmaceutical Co., Experimental Station, Wilmington, Delaware 19880-0336, USA.
Strack
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P
Frey
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MW
Rizzo
C J
CJ
D017209:Apoptosis; D016333:HIV Protease / Q000378:metabolism*; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*
D019253:Proto-Oncogene Proteins c-bcl-2; D016333:HIV Protease