Induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide.
In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high-dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non-genotoxic, proliferation-dependent mechanism.
Takegawa
K
K
Division of Pathology, National Institute of Health Sciences, Tokyo.
Mitsumori
K
K
Onodera
H
H
Yasuhara
K
K
Kitaura
K
K
Shimo
T
T
Takahashi
M
M
D000284:Administration, Oral; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D005260:Female; D008297:Male; D011193:Potassium Iodide / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012468:Salivary Gland Neoplasms / Q000150:complications* / Q000473:pathology; D014867:Water
D014867:Water; D011193:Potassium Iodide