title: Effect of recirculation of 99mTc-Sn colloid in estimating mean transit time of soft-tissue vascular anomalies by direct puncture scintigraphy: a simulation analysis.
abstract: We have reported direct puncture scintigraphy, a novel method to estimate mean transit time (MTT) of soft-tissue vascular anomaly. In the examination, 99mTc-Sn colloid is infused percutaneously into the lesion, and MTT is calculated using the time-activity curve for the lesion. Recirculation of 99mTc-Sn colloid is neglected in computing MTT, and this may cause error. The aim of this study was to assess this error by simulation analysis. Data simulating direct puncture scintigraphy were produced for lesions with various blood volumes and various blood flows, considering recirculation and blood clearance of 99mTc-Sn colloid, and MTT was estimated by the same method used in the patient examination. Although MTT was overestimated in large lesions with intermediate or long MTT, the error was small except in extremely large lesions. It was suggested that recirculation of 99mTc-Sn colloid does not cause a serious problem in the clinical use of direct puncture scintigraphy.
authors.affiliation: Department of Radiology, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Ohtake
authors.forename: S
authors.initials: S
authors.lastname: Wakita
authors.forename: N
authors.initials: N
authors.lastname: Yoshioka
authors.forename: J
authors.initials: J
authors.lastname: Nishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
mesh_terms: D001165:Arteriovenous Malformations / Q000000981:diagnostic imaging*; D001783:Blood Flow Velocity; D003102:Colloids; D003198:Computer Simulation; D006391:Hemangioma / Q000000981:diagnostic imaging*; D006801:Humans; D011877:Radionuclide Imaging; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging*; D017556:Technetium Compounds; D017971:Tin Compounds
chemical_list: D003102:Colloids; D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid