Is there IgA from gut mucosal origin in the serum of children with Henoch-Schönlein purpura?
Thirty-two children with Henoch-Schönlein purpura with or without renal symptoms were studied to characterize the IgA hyperglobulinemia observed in the serum of most patients. It was shown that only the IgA1 subclass concentration was increased. Secretory IgA and IgA to gliadin levels were frequently increased in serum, with a good correlation between them. Circulating IgA immune complexes were detected often and contained high activity to gliadin. In contrast, IgA activity to tetanus toxoid did not change. We failed to show any differences in renal involvement. These data suggest that elevation of serum IgA in Henoch-Schönlein purpura is due in part to a disturbance of the gut mucosal immune system, and the presence of circulating IgA immune complexes with dietary antigens can be postulated but cannot explain the occurrence of urinary symptoms.
Moja
P
P
Laboratory of Research in Immunology, University of Saint-Etienne, France.
Quesnel
A
A
Resseguier
V
V
Lambert
C
C
Freycon
F
F
Berthoux
F
F
Genin
C
C
D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D011695:IgA Vasculitis / Q000276:immunology*; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000097:blood*; D007071:Immunoglobulin A, Secretory / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007413:Intestinal Mucosa / Q000276:immunology*; D007674:Kidney Diseases / Q000276:immunology; D008297:Male; D013745:Tetanus Toxoid / Q000276:immunology
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D013745:Tetanus Toxoid; D005903:Gliadin