title: The genetics of ovarian cancer: molecular biology and clinical application.
abstract: Ovarian cancer is the fifth most common malignancy among American women and the fourth leading cause of cancer death. The rapid advances in molecular genetic analysis, presymptomatic detection, and treatment of ovarian cancer are staggering. In this review, both the genetic component and the molecular biology of ovarian cancer are discussed, as well as current recommendations for genetic counseling. It is important for the practicing obstetrician and gynecologist to become familiar with these concepts, for it is he or she who will likely serve as a primary resource of information for these patients.
authors.affiliation: Program in Woman's Oncology, Woman and Infants Hospital, Providence, RI 02905-2499, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: DePasquale
authors.forename: A
authors.initials: A
authors.lastname: Giordano
authors.forename: A E
authors.initials: AE
authors.lastname: Donnenfeld
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications; D005260:Female; D019398:Genes, BRCA1; D016147:Genes, Tumor Suppressor; D005817:Genetic Counseling; D006801:Humans; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics*; D011519:Proto-Oncogenes