Regulation of cell cycle progression following DNA damage.
DNA damage causes an arrest in cell cycle progression. Checkpoints, which monitor the state of the DNA, exist throughout the cycle and negatively regulate cell cycle transitions when damage is detected. The molecular basis of how these checkpoints are activated, and interact with the cell cycle machinery, is just beginning to be understood. Studies in yeast have identified a number of genes involved in a G2 DNA damage checkpoint, while in mammalian cells a G1 checkpoint has been extensively studied.
Hensey
C
C
Roche Institute of Molecular Biology, Nutley, NJ 07110, USA.
Gautier
J
J
D002453:Cell Cycle; D004249:DNA Damage; D004261:DNA Replication; D019204:GTP-Binding Proteins / Q000235:genetics; D016158:Genes, p53; D006801:Humans; D008938:Mitosis; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology; D018631:ras Proteins
C084355:RRAD protein, human; D019204:GTP-Binding Proteins; D018631:ras Proteins