title: The assessment of platelet derived growth factor concentration in post myocardial infarction and stable angina patients.
abstract: Platelet derived growth factor (PDGF) has been implicated in the pathogenesis of atherosclerosis. PDGF is released by aggregating platelets and monocytes which gather around sites of arterial injury. In the study reported here the concentration of plasma PDGF was measured in post myocardial infarction (MI) patients (n = 28), angina patients (n = 25), and control subjects (n = 27). Venous blood samples were taken and the concentration of PDGF determined by an enzyme linked immunosorbent assay (ELISA). Plasma PDGF concentrations were significantly higher in the post MI group compared to both the control and angina groups (P < or = 0.05). The increase in PDGF concentration may be due to increased activation of platelets or monocytes since these two cells are major sources of plasma PDGF. High concentrations of PDGF in the circulation could further accelerate the progression of the disease.
authors.affiliation: Northern Ireland Centre for Diet and Health, School of Biomedical Sciences, University of Ulster, Coleraine, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Wallace
authors.forename: J C
authors.initials: JC
authors.lastname: Freeburn
authors.forename: W S
authors.initials: WS
authors.lastname: Gilmore
authors.forename: D G
authors.initials: DG
authors.lastname: Sinnamon
authors.forename: B M
authors.initials: BM
authors.lastname: Craig
authors.forename: R J
authors.initials: RJ
authors.lastname: McNally
authors.forename: J J
authors.initials: JJ
authors.lastname: Strain
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000188:drug therapy; D001835:Body Weight; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy; D010982:Platelet-Derived Growth Factor / Q000032:analysis*; D011237:Predictive Value of Tests
chemical_list: D010982:Platelet-Derived Growth Factor