title: Glycosidopyrroles. Part 1. Acyclic derivatives: 1-(2-hydroxyethoxy)methylpyrroles as potential anti-viral agents.
abstract: Acyclic glycosidopyrroles of type 1, synthesized in good overall yields, were evaluated for anti-viral activity. Compound 10i was found to inhibit the HIV-1 replication at concentrations that were very close to those cytotoxic for MT-4 cells. Compounds 10a,f,i inhibited both strains HSV-1 and HSV-2 at concentrations slightly below those cytotoxic for Vero cells. However for this series of glycosidopyrroles some relationship between calculated log P values and the observed cytotoxicity was found.
authors.affiliation: Istituto Farmacochimico, Università degli Studi, Palermo, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Almerico
authors.forename: P
authors.initials: P
authors.lastname: Diana
authors.forename: P
authors.initials: P
authors.lastname: Barraja
authors.forename: G
authors.initials: G
authors.lastname: Dattolo
authors.forename: F
authors.initials: F
authors.lastname: Mingoia
authors.forename: A G
authors.initials: AG
authors.lastname: Loi
authors.forename: F
authors.initials: F
authors.lastname: Scintu
authors.forename: C
authors.initials: C
authors.lastname: Milia
authors.forename: I
authors.initials: I
authors.lastname: Puddu
authors.forename: P
authors.initials: P
authors.lastname: La Colla
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D011758:Pyrroles