title: Langerhans cell histiocytosis research. Past, present, and future.
abstract: This article reviews the various investigative events that led to the endorsement of the term Langerhans cell histiocytosis for the various clinicopathologic conditions previously called Hand-Schüller-Christian disease, Abt-Letterer-Siwe disease, eosinophilic granuloma of bone, and histiocytosis X. The different denominations reflect the changing conceptual approaches to the so-called reticuloendothelial system and the successive acquisition of new ultrastructural and immunocytochemical data.
authors.affiliation: Department of Pathology, Faculté de Médecine de Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Nezelof
authors.forename: F
authors.initials: F
authors.lastname: Basset
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000276:immunology; D002450:Cell Communication; D002455:Cell Division; D016207:Cytokines / Q000276:immunology; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology*; D012157:Mononuclear Phagocyte System / Q000276:immunology* / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D016207:Cytokines