title: Highly resolved chemical imaging of living cells by using synchrotron infrared microspectrometry.
abstract: Using synchrotron radiation as an ultra-bright infrared source, we have been able to map the distributions of functional groups such as proteins, lipids, and nucleic acids inside a single living cell with a spatial resolution of a few microns. In particular, we have mapped the changes in the lipid and protein distributions in both the final stages of cell division and also during necrosis.
authors.affiliation: Commissariat à l'Energie Atomique-Institut National des Sciences et Techniques Nucléaires, F91191 Gif Sur Yvette Cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Jamin
authors.forename: P
authors.initials: P
authors.lastname: Dumas
authors.forename: J
authors.initials: J
authors.lastname: Moncuit
authors.forename: W H
authors.initials: WH
authors.lastname: Fridman
authors.forename: J L
authors.initials: JL
authors.lastname: Teillaud
authors.forename: G L
authors.initials: GL
authors.lastname: Carr
authors.forename: G P
authors.initials: GP
authors.lastname: Williams
mesh_terms: D000818:Animals; D002451:Cell Compartmentation; D016923:Cell Death; D002455:Cell Division; D006825:Hybridomas; D050356:Lipid Metabolism; D051379:Mice; D009336:Necrosis; D013055:Spectrophotometry, Infrared / Q000379:methods*; D017356:Synchrotrons