title: Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan.
authors.affiliation: Royal London School of Medicine and Dentistry, United Kingdom.
authors.forename: M P
authors.initials: MP
authors.lastname: Seed
authors.forename: C N
authors.initials: CN
authors.lastname: Freemantle
authors.forename: C A
authors.initials: CA
authors.lastname: Alam
authors.forename: P R
authors.initials: PR
authors.lastname: Colville-Nash
authors.forename: J R
authors.initials: JR
authors.lastname: Brown
authors.forename: J L
authors.initials: JL
authors.lastname: Papworth
authors.forename: K W
authors.initials: KW
authors.lastname: Somerville
authors.forename: D A
authors.initials: DA
authors.lastname: Willoughby
mesh_terms: D000287:Administration, Topical; D000818:Animals; D017209:Apoptosis; D001241:Aspirin / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000473:pathology*; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D004337:Drug Carriers; D005260:Female; D006820:Hyaluronic Acid; D007527:Isoenzymes / Q000378:metabolism*; D008565:Membrane Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D010894:Piroxicam / Q000633:toxicity; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D013449:Sulfonamides / Q000633:toxicity
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D004337:Drug Carriers; D007527:Isoenzymes; D008565:Membrane Proteins; D013449:Sulfonamides; D010894:Piroxicam; D004008:Diclofenac; D006820:Hyaluronic Acid; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; C496512:Ptgs1 protein, mouse; D001241:Aspirin; C012655:nimesulide