A novel DEAD-box RNA helicase exhibits high sequence conservation from yeast to humans.
We have identified a novel Drosophila protein, DBP80, that exhibits significant similarity to mouse mDEAD5, yeast TIF1/2, and mammalian eIF-4A. DBP80 is a member of a subclass of DEAD-box proteins that contains a distinct domain, PX(I/R)ILLKR(E/D)EETLEGIKQ(F/Y)(F/Y), in addition to the seven canonical helicase domains.
Eisen
A
A
Department of Biology, Emory University, Atlanta, GA 30322, USA.
Sattah
M
M
Gazitt
T
T
Neal
K
K
Szauter
P
P
Lucchesi
J
J
D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000737:chemistry*; D016601:RNA-Binding Proteins
C083965:Dbp45A protein, Drosophila; D029721:Drosophila Proteins; D019476:Insect Proteins; D016601:RNA-Binding Proteins; D012316:RNA Nucleotidyltransferases; D020365:RNA Helicases