Glycosidopyrroles. Part 1. Acyclic derivatives: 1-(2-hydroxyethoxy)methylpyrroles as potential anti-viral agents.
Acyclic glycosidopyrroles of type 1, synthesized in good overall yields, were evaluated for anti-viral activity. Compound 10i was found to inhibit the HIV-1 replication at concentrations that were very close to those cytotoxic for MT-4 cells. Compounds 10a,f,i inhibited both strains HSV-1 and HSV-2 at concentrations slightly below those cytotoxic for Vero cells. However for this series of glycosidopyrroles some relationship between calculated log P values and the observed cytotoxicity was found.
Almerico
A M
AM
Istituto Farmacochimico, Università degli Studi, Palermo, Italy.
Diana
P
P
Barraja
P
P
Dattolo
G
G
Mingoia
F
F
Loi
A G
AG
Scintu
F
F
Milia
C
C
Puddu
I
I
La Colla
P
P
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D014709:Vero Cells
D000998:Antiviral Agents; D011758:Pyrroles