Green tea suppresses D-galactosamine-induced liver injury in rats.
Dietary supplementation with powder of a green tea extract suppressed the enhancement of plasma alanine aminotransferase and aspartate aminotransferase activities induced by D-galactosamine, but not by carbon tetrachloride, in a dose-dependent manner in rats. The minimum dose to cause a significant effect was 1 to 2%. Drinking green tea also suppressed plasma enzyme activities. These results indicate that green tea had a liver injury-preventive effect.
Sugiyama
K
K
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Japan.
He
P
P
Wada
S
S
Tamaki
F
F
Saeki
S
S
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D019587:Dietary Supplements; D005688:Galactosamine / Q000633:toxicity*; D008107:Liver Diseases / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013662:Tea
D010936:Plant Extracts; D013662:Tea; D005688:Galactosamine; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase