title: Differential TCR signaling and the generation of memory T cells.
abstract: There are currently two models for the generation of memory T cells: 1) memory T cells arise directly from activated effector T cells that have reverted to the resting state via an unknown mechanism; and 2) memory T cells are generated directly from naive T cells, bypassing an effector stage. I discuss here how recent results on the activation and signaling requirements of naive vs memory CD4 T cells favor the second model and how differential signaling of naive T cells may direct their developmental outcome.
authors.affiliation: Department of Microbiology, University of Maryland, College Park 20742, USA. dfarber@microb.umd.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Farber
mesh_terms: D000818:Animals; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D011948:Receptors, Antigen, T-Cell