Cell cycle-regulated transcription in mammalian cells.
The periodic, phase-specific transcription of defined sets of genes is a hallmark of cell cycle progression in all organisms (1-3). In this article, we will summarise our current knowledge and views of the mechanisms governing the cross-coupling of cell cycle control and transcriptional regulation in mammalian cells, with particular emphasis on the transcription factor E2F and the retinoblastoma protein pRb (1-3). Excluded from this review will be the genomic response to mitogenic stimulation, which is part of the mitogen-triggered signal transduction cascades rather than a reflection of cell cycle regulation (4).
Zwicker
J
J
Institut für Molekular-biologie und Tumorforschung (IMT), Philipps-Universität Marburg, Germany.
Müller
R
R
D000818:Animals; D002352:Carrier Proteins; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D005786:Gene Expression Regulation; D008322:Mammals; D016160:Retinoblastoma Protein / Q000502:physiology; D056465:Retinoblastoma-Binding Protein 1; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D020687:cdc25 Phosphatases
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D016160:Retinoblastoma Protein; D056465:Retinoblastoma-Binding Protein 1; D014157:Transcription Factors; D020687:cdc25 Phosphatases