title: Transferable, plasmid-mediated vanB-type glycopeptide resistance in Enterococcus faecium.
abstract: An approximately 60-kb transferable, vanB-carrying plasmid has been identified in a clinical Enterococcus faecium strain. A similar plasmid has been observed in an unrelated E. faecium strain, suggesting that plasmid transfer of vanB operons occurs in nature and plays a role in the dissemination of VanB-type resistance among strains of E. faecium.
authors.affiliation: Cleveland Department of Veterans Affairs Medical Center, Department of Medicine, Case Western Reserve University School of Medicine, Ohio 44106, USA. lbr@po.cwru.edu
authors.forename: L B
authors.initials: LB
authors.lastname: Rice
authors.forename: L L
authors.initials: LL
authors.lastname: Carias
authors.forename: C L
authors.initials: CL
authors.lastname: Donskey
authors.forename: S D
authors.initials: SD
authors.lastname: Rudin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D004352:Drug Resistance, Microbial / Q000235:genetics*; D016984:Enterococcus faecium / Q000187:drug effects* / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics*; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D014640:Vancomycin