title: Imipramine in the treatment of social phobia.
abstract: We report the results of an 8-week open trial of imipramine in 15 patients with social phobia. Nine patients completed the trial; six dropped out early because of adverse effects. The mean reduction in the Liebowitz Social Anxiety Scale was 15% and 18% for the intent-to-treat and completer groups, respectively; the overall response rate (based on the Clinical Global Impression Scale of 1 or 2, very much or much improved) was 20% (3/15) and 22% (2/9), respectively. The results from this open trial do not support the efficacy of imipramine as a treatment for social phobia.
authors.affiliation: New York State Psychiatric Institute, Anxiety Disorders Clinic, NY 10032, USA.
authors.forename: H B
authors.initials: HB
authors.lastname: Simpson
authors.forename: F R
authors.initials: FR
authors.lastname: Schneier
authors.forename: R B
authors.initials: RB
authors.lastname: Campeas
authors.forename: R D
authors.initials: RD
authors.lastname: Marshall
authors.forename: B A
authors.initials: BA
authors.lastname: Fallon
authors.forename: S
authors.initials: S
authors.lastname: Davies
authors.forename: D F
authors.initials: DF
authors.lastname: Klein
authors.forename: M R
authors.initials: MR
authors.lastname: Liebowitz
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010698:Phobic Disorders / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D016037:Single-Blind Method
chemical_list: D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine