Mechanisms and clinical significance of cell volume regulation.
A wide variety of factors challenge constancy of cell volume. Alterations of cell volume activate diverse cell volume regulatory mechanisms including ion transport, osmolyte accumulation, metabolism and expression of appropriate genes. A wealth of cellular signalling pathways link cell volume to the respective regulatory mechanisms. Cell volume emerges as a pathophysiologically important parameter in several diseases including diabetes mellitus, uraemia, hepatic insufficiency and hypercatabolic states. The role of altered cell volume in disease is a challenge which requires more experimental research and clinical investigation.
Waldegger
S
S
Department of Physiology, University of Tübingen, Germany.
Steuer
S
S
Risler
T
T
Heidland
A
A
Capasso
G
G
Massry
S
S
Lang
F
F
D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D048429:Cell Size; D006801:Humans; D017136:Ion Transport; D007674:Kidney Diseases / Q000473:pathology*; D015398:Signal Transduction