Regulation of apoptosis by presenilin 1.
Familial Alzheimer's disease is transmitted as an autosomal dominant disorder and, in 5-10% of the cases, is caused by mutations in the coding regions of two homologous genes, Presenilin 1 and 2 (PS1 and PS2). Previously, we have shown that PS2, a homolog of PS1. regulates apoptosis induced in neurons by trophic withdrawal or Abeta, and in T-cells by Fas ligand. We now report that PS1 also regulates apoptosis. Both wild-type and the H115Y mutant form of PS1 enhance Fas-mediated apoptosis in Jurkat cells. We also observed that wild-type and the H115Y mutant form of PS1 differentially regulate Jun Kinase, an important enzyme regulating apoptosis.
Wolozin
B
B
Department of Pharmacology, Loyola University Medical Center, Maywood, IL 60153, USA. bwolozi@wpo.it.luc.edu
Alexander
P
P
Palacino
J
J
D000375:Aging / Q000378:metabolism; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D015153:Blotting, Western; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002460:Cell Line; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases; D019169:Jurkat Cells; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases; D009154:Mutation; D010084:Oxidation-Reduction; D053764:Presenilin-1; D014162:Transfection; D019014:fas Receptor / Q000378:metabolism
D004273:DNA, Neoplasm; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D019014:fas Receptor; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases