Late endocrine effects of ovarian electrocautery in women with polycystic ovary syndrome.
OBJECTIVE
To examine the duration of the changes in endocrine indices produced by ovarian electrocautery in women with polycystic ovary syndrome (PCOS).


METHODS
Long-term observational study.


METHODS
University hospital.


METHODS
Infertile women with PCOS.


METHODS
Ovarian electrocautery was performed through the laparoscope. Blood was sampled before the operation and at defined intervals thereafter. After the establishment of regular cycles, sampling was performed 1 week before the menstrual period.


METHODS
The patients were observed before and at defined intervals for up to 20 years after ovarian electrocautery. Serum concentrations of hypophyseal and ovarian hormones were determined, including sex hormone-binding globulin (SHBG).


RESULTS
There was a clear shift from anovulation to ovulatory cycles and a significant decrease in androgens and gonadotropins. The concentration of SHBG increased. These effects lasted for many years; after 18-20 years, two thirds of the women were still ovulating.


CONCLUSIONS
Ovarian electrocautery for PCOS normalizes ovarian function, including androgen production, and the results seem to be stable for 18-20 years.
Gjønnaess
H
H
Department of Gynecology, Aker University Hospital, Oslo, Norway.
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood / Q000378:metabolism; D000328:Adult; D000735:Androstenedione / Q000097:blood / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood / Q000378:metabolism; D013196:Dihydrotestosterone / Q000097:blood / Q000378:metabolism; D004564:Electrocoagulation; D004958:Estradiol / Q000097:blood / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood* / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000097:blood* / Q000378:metabolism; D006801:Humans; D010535:Laparoscopy; D008137:Longitudinal Studies; D010060:Ovulation / Q000097:blood / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism / Q000601:surgery*; D011374:Progesterone / Q000097:blood / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000032:analysis / Q000378:metabolism; D013739:Testosterone / Q000097:blood / Q000378:metabolism; D013997:Time Factors
D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D019326:17-alpha-Hydroxyprogesterone