title: Differences in Epstein-Barr virus expression between primary and secondary cutaneous angiocentric lymphomas. French Study Group of Cutaneous Lymphomas.
abstract: BACKGROUND
  Epstein-Barr virus (EBV) has been demonstrated in angiocentric immunoproliferative lesions, suggesting that it could be a causative factor. We investigated for the presence of EBV in 12 primary and 2 secondary cutaneous angiocentric lymphomas (CALs).
  
  
  METHODS
  In the 2 secondary CALs, strong reactivity for EBV RNAs and latent membrane protein 1 were detected on paraffin-embedded sections. In contrast, 10 of 12 primary CALs were completely negative for EBV RNAs and latent membrane protein 1. In 2 primary CALs, EBV RNAs and latent membrane protein 1 were detected in few tumor cells. In the group of primary CALs, 8 of 12 were still alive at last follow-up, 3 died of systemic lymphoma, and 1 died of another cause, whereas both patients with secondary CALs died of disease within 1 year.
  
  
  CONCLUSIONS
  Differences in the presence of EBV and clinical behavior between primary and secondary CALs suggest that different mechanisms are operative in the pathogenesis of these conditions, and indicate that the 2 groups should be considered separately.
authors.affiliation: Department of Pathology, Hôpital Henri-Mondor, Créteil, France.
authors.forename: J
authors.initials: J
authors.lastname: Wechsler
authors.forename: R
authors.initials: R
authors.lastname: Willemze
authors.forename: A
authors.initials: A
authors.lastname: van der Brule
authors.forename: E
authors.initials: E
authors.lastname: Thomine
authors.forename: P
authors.initials: P
authors.lastname: Joly
authors.forename: O
authors.initials: O
authors.lastname: Verola
authors.forename: Y
authors.initials: Y
authors.lastname: Fonck
authors.forename: P
authors.initials: P
authors.lastname: Souteyrand
authors.forename: M H
authors.initials: MH
authors.lastname: Delfau
authors.forename: M
authors.initials: M
authors.lastname: Bagot
authors.forename: P
authors.initials: P
authors.lastname: Gaulard
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology / Q000821:virology*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology / Q000821:virology*; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology*; D014763:Viral Matrix Proteins / Q000032:analysis
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D012367:RNA, Viral; D014763:Viral Matrix Proteins