[The characteristics of the action of nondepolarizing myorelaxants during operations on children with thermal injuries].
Effects of nondepolarizing myorelaxants pancuronium, arduan, and tracrium were studied during surgery in 347 children with thermal injuries aged from several months to 15 years. Nondepolarizing myorelaxants are drugs of choice for providing myoplegia in children operated on for thermal injuries. The optimal initial dose of these agents in children with burns is 30-50% higher than the recommended dose and depends on the size of the lesion. For controllable myoplegia, the doses of subsequent injections are to be 1.-5-2 times lowered in comparison with the initial dose. The effects of pancuronium and arduan depend on the hepatorenal function. Tracrium ensures sufficient controllable myorelaxation in children with burns even in cases with hepatorenal dysfunction.
Stepanova
N A
NA
Tabakina
T E
TE
Krasovskiĭ
V A
VA
Oleĭnikova
Ia V
IaV
Pogrebova
T K
TK
Smirnova
S E
SE
Tkachenko
B A
BA
Karpovich
S V
SV
D000208:Acute Disease; D000293:Adolescent; D000768:Anesthesia, General; D001279:Atracurium / Q000008:administration & dosage*; D002056:Burns / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007430:Intraoperative Care / Q000379:methods*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D010197:Pancuronium / Q000008:administration & dosage*; D017300:Pipecuronium / Q000008:administration & dosage*; D013997:Time Factors
D003473:Neuromuscular Nondepolarizing Agents; D017300:Pipecuronium; D001279:Atracurium; D010197:Pancuronium