Galectin-1 and -3 in cells of the first trimester placental bed.
The beta-galactoside-binding proteins galectin-1 and -3 are thought to modulate cell-extracellular matrix interactions in cell adhesion and migration. In this study, their occurrence in human trophoblast has been investigated. In the first trimester placenta galectin-1 is expressed in the cytotrophoblast of the mid and distal cell columns, but absent from the villous and proximal column cytotrophoblast. The villous syncytiotrophoblast was also positive. Galectin-3, on the other hand, was uniformly localized in the villous cytotrophoblast and mid and distal cell columns. Immunolocalization of these proteins in placental bed tissue has shown that galectin-1 and -3 are not present in cytokeratin-positive interstitially migrating cytotrophoblast. The co-localization of galectin-1 with extracellular laminin in cultures of cytotrophoblast, choriocarcinoma or decidual stromal cells is consistent with a role in the organization of extracellular matrix and the regulation of cell motility.
Vićovac
L
L
INEP, University of Belgrade, Zemun, Yugoslavia.
Janković
M
M
Cuperlović
M
M
D000943:Antigens, Differentiation / Q000032:analysis*; D002478:Cells, Cultured; D003656:Decidua / Q000737:chemistry; D005260:Female; D037483:Galectin 1; D037502:Galectin 3; D006388:Hemagglutinins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D007797:Laminin / Q000032:analysis; D008562:Membrane Glycoproteins / Q000032:analysis; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D017154:Stromal Cells / Q000737:chemistry; D014018:Tissue Distribution; D014327:Trophoblasts / Q000737:chemistry*
D000943:Antigens, Differentiation; D037483:Galectin 1; D037502:Galectin 3; D006388:Hemagglutinins; D007797:Laminin; D008562:Membrane Glycoproteins; D007633:Keratins