title: Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia.
abstract: Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University Medical Center, Indianapolis, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Bartlett
authors.forename: M M
authors.initials: MM
authors.lastname: Shaw
authors.forename: J W
authors.initials: JW
authors.lastname: Smith
authors.forename: S R
authors.initials: SR
authors.lastname: Meshnick
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D051381:Rats; D013421:Sulfamethoxypyridazine / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013421:Sulfamethoxypyridazine