Identification of significant variation in the composition of lipophosphoglycan-like molecules of E. histolytica and E. dispar.
The lipophosphoglycan-like (LPG-like) molecules of E. histolytica virulent strains are clearly distinct from those of the avirulent E. histolytica and E. dispar strains. Abundant 'LPG' levels are apparently limited to virulent strains, while lipophosphopeptidoglycans ('LPPG's) are common to both virulent and avirulent strains of E. histolytica and E. dispar. It is therefore conceivable that 'LPPG' performs a function that is essential to survival within the host, while the 'LPG' performs a more specific function related to virulence.
Moody
S
S
Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.
Becker
S
S
Nuchamowitz
Y
Y
Mirelman
D
D
D000818:Animals; D002847:Chromatography, Agarose; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D004747:Entamoeba / Q000737:chemistry*; D004748:Entamoeba histolytica / Q000737:chemistry* / Q000472:pathogenicity; D005434:Flow Cytometry; D006028:Glycosphingolipids / Q000737:chemistry* / Q000302:isolation & purification; D006168:Guinea Pigs; D006367:HeLa Cells; D006790:Host-Parasite Interactions / Q000502:physiology; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D008101:Liver Abscess, Amebic / Q000469:parasitology; D008970:Molecular Weight; D011506:Proteins / Q000737:chemistry; D014774:Virulence
D006028:Glycosphingolipids; D007106:Immune Sera; D011506:Proteins; C008290:lipophosphonoglycan