Proconvulsant effects induced by pyridoxine in young rats.
High doses of pyridoxine (vitamin B6) can be neurotoxic in adults. Effects of intraperitoneally administered B6 (100, 250 and 400 mg/kg) were studied in 7, 12, 18 and 60 day old rats. B6 elicited epileptiform EEG discharges without any motor correlate in all age groups. In contrast, motor seizures were rare, seen only in 18 day old rats (250 mg/kg of B6). Data indicate that in young rats, B6 may have proconvulsant effects in doses relevant to those sometimes used in pediatric neurology.
Veresová
S
S
Department of Pathological Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Kábová
R
R
Velísek
L
L
D000375:Aging / Q000502:physiology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000503:physiopathology; D003292:Convulsants / Q000633:toxicity*; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011736:Pyridoxine / Q000633:toxicity*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D012727:Sex Characteristics
D003292:Convulsants; D011736:Pyridoxine