[Immunology in medical practice. V. Constitutional eczema].
Constitutional eczema (late atopic dermatitis) is a frequent condition: some 30% of the skin diseases seen by the GP involve constitutional eczema. A number of links with (external) factors have meanwhile been established. Patients with constitutional eczema often suffer from food allergy (over 60% of the children with the eczema) and many are allergic to airborne allergens (especially housedust mite allergen). The skin of patients with constitutional eczema has a diminished barrier function against irritants (soaps, acids, bases, water, detergents, biological juices (fruit, meat, fish, vegetables). In 90% of the patients with constitutional eczema the skin contains colonies of Staphylococcus aureus (in 5% of people without eczema). S. aureus can influence the eczema through exoantigens (so-called superantigens) and through conventional antigens that may evoke an IgE-mediated immune response. Emotional stress may influence the eczema. The close anatomical relationship between mast cells and nerve endings and between Langerhans cells and nerve endings suggest that the autonomous nervous system can modulate the immune system of the skin and consequently, the eczema. These factors should be taken into account in the treatment: reduction of exposure to food and airborne allergens and to irritants, treatment and prevention of S. aureus infections and psychological support. New therapies include cyclosporine, autologous IgG antigen complexes and phototherapy.
Langeveld-Wildschut
E G
EG
Academisch Ziekenhuis, afd. Dermatologie-Allergologie, Utrecht.
van Ginkel
C J
CJ
Koers
W J
WJ
de Maat-Bleeker
F
F
Felius
A
A
Bruijnzeel-Koomen
C A
CA
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D001341:Autonomic Nervous System / Q000276:immunology; D003131:Combined Modality Therapy; D004485:Eczema / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000276:immunology*; D007223:Infant; D012867:Skin / Q000294:innervation; D013203:Staphylococcal Infections / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000276:immunology; D018089:Superantigens / Q000276:immunology
D000942:Antigens, Bacterial; D018089:Superantigens