title: Characteristics of chronic venous insufficiency in 895 patients followed in general practice.
abstract: BACKGROUND
  This study was designed to describe the main semiological and etiological characteristics of chronic venous insufficiency (CVI) and to determine if there was a relationship between the extent of objective signs, severity of symptoms and aetiology.
  
  
  METHODS
  895 outpatients presenting CVI of the lower limbs over a period of at least one year, irrespective of grade of severity or aetiology, were included in this retrospective study. They were treated with 2 different pharmaceutical forms of the same venoactive medication (1000 mg of micronised flavonoid fraction) for 2 months. Organic CVI (OCVI) was classified, in stages of increasing severity, according to the Widmer and Porter classification. In the absence of anatomical lesions of the main veins or their valvular system, CVI was termed functional (FCVI).
  
  
  RESULTS
  Analysis indicated that CVI was more frequent in women than in men (sex ratio 10:1). 26% were FCVI and 91% of OCVI were of varicose origin. The mean progression time of the disease was 13+/-11 years. Disease began earlier in women than in men (34+/-14 vs 41+/-14 years). Oedema was the first objective sign in 68% of patients and the only one in 20% of FCVI. Heaviness was more frequent in FCVI and its intensity was not related to the severity of CVI. Trophic complications were more frequent in the advanced stages.
  
  
  CONCLUSIONS
  In order to avoid progression to more severe forms which are disabling or expensive to treat, a rational approach to the management of early CVI is essential.
authors.affiliation: Service de Médecine Interne et Angéiologie, Hôpital de Rangueil, Toulouse, France.
authors.forename: H
authors.initials: H
authors.lastname: Boccalon
authors.forename: C
authors.initials: C
authors.lastname: Janbon
authors.forename: J L
authors.initials: JL
authors.lastname: Saumet
authors.forename: A
authors.initials: A
authors.lastname: Tafani
authors.forename: T
authors.initials: T
authors.lastname: Roux
authors.forename: C
authors.initials: C
authors.lastname: Vilain
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D004145:Diosmin / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014648:Varicose Veins / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D014689:Venous Insufficiency / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D004145:Diosmin