Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease.
Oxidative stress in the central nervous system (CNS) may cause oxidation of lipoprotein particles. The oxidized lipoproteins may damage cellular and subcellular membranes, leading to tissue injury and cell death. Human low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) are oxidized by transition metal ions, such as Cu2+. Using PC 12 cells, we tested the cytotoxicity of oxidized LDL and VLDL. Cell death was increased in a dose-dependent manner. Antioxidants added to the incubation medium, such as vitamins E or C, or resveratrol showed some protection. Results indicated that oxidized lipoproteins may serve as an oxidative stressor, which may initiate the neuronal cell death leading to the manifestation of Alzheimer disease (AD).
Draczynska-Lusiak
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Department of Pharmacology, University of Missouri, Columbia 65212, USA.
Doung
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A
Sun
A Y
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D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D001921:Brain / Q000473:pathology*; D016923:Cell Death / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008077:Lipoproteins, LDL / Q000633:toxicity*; D008079:Lipoproteins, VLDL / Q000633:toxicity*; D009474:Neurons / Q000187:drug effects / Q000473:pathology*; D018696:Neuroprotective Agents / Q000494:pharmacology; D016716:PC12 Cells; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D018696:Neuroprotective Agents; C099252:oxidized low density lipoprotein; C108132:oxidized very low density lipoprotein; D014810:Vitamin E; D001205:Ascorbic Acid