Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria.
Syntheses of imidazo-pyridines and substituted prolines and their effect on heme oxygenase activity of Plasmodium yoelii and corresponding infected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further exploited in the development of resistant reversal agents.
Srivastava
P
P
Biochemistry Division, Central Drug Research Institute, Lucknow, India.
Pandey
V C
VC
Misra
A P
AP
Gupta
P
P
Raj
K
K
Bhaduri
A P
AP
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000627:therapeutic use; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors*; D008288:Malaria / Q000188:drug therapy* / Q000201:enzymology; D051379:Mice; D010967:Plasmodium yoelii / Q000201:enzymology*; D011725:Pyridines / Q000737:chemistry* / Q000627:therapeutic use
D000962:Antimalarials; D004791:Enzyme Inhibitors; D011725:Pyridines; D002738:Chloroquine; D006419:Heme Oxygenase (Decyclizing); C001439:imidazo(1,2-a)pyridine