Fluconazole pharmacokinetics in burn patients.
The pharmacokinetics of fluconazole in nine adult patients with severe (30 to 95% total body surface area) burns were studied. There was no significant difference in half-life (t1/2), clearance (CL), or volume of distribution (V) over time in five patients on days 3 and 8 of the study (P > 0.05). Combined parameter estimates (means +/- standard deviations) for all nine patients for the two study periods were as follows: t1/2, 24.4 +/- 5.8 h; CL, 0.36 +/- 0.09 ml/min/kg; and V, 0.72 +/- 0.12 liters/kg. These estimates of t1/2 and CL in burn patients were approximately 13% shorter and 30% more rapid, respectively, than the most extreme estimates reported for other populations.
Boucher
B A
BA
Department of Clinical Pharmacy, University of Tennessee, Memphis 38163, USA. bboucher@utmem1.utmem.edu
King
S R
SR
Wandschneider
H L
HL
Hickerson
W L
WL
Hanes
S D
SD
Herring
V L
VL
Canada
T W
TW
Hess
M M
MM
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002056:Burns / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004311:Double-Blind Method; D005260:Female; D015725:Fluconazole / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; D015725:Fluconazole