Synthesis and biological activity of some 4-amino-3-cinnoline carboxylic acid derivatives. Part 4: 2,4-Dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines.
A series of new 2,4-dioxo-1,2,3,4-tetrahydropyrimido[5,4-c]cinnolines and their 3-substituted derivatives were prepared. These compounds were obtained by cyclocondensation of the appropriate substituted 4-amino-3-cinnolinecarboxylic acid with urea or 4-amino-3-cinnolinecarboxamides with N,N'-carbonyldiimidazole (DCl), oxalyl chloride or diethyl carbonate. Most of these compounds showed a high sedative action in low doses.
Stańczak
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Department of Pharmaceutical Chemistry and Drug Analysis, Medical University Lódź, Poland.
Lewgowd
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Pakulska
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D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D006380:Helplessness, Learned; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology
D018712:Analgesics, Non-Narcotic; D002264:Carboxylic Acids; D006993:Hypnotics and Sedatives; D012702:Serotonin Antagonists