Failure of the cultivated mushroom (Agaricus bisporus) to induce tumors in the A/J mouse lung tumor model.
We studied whether the cultivated mushroom (Agaricus bisporus) or 4-(carboxy)phenylhydrazine (CP) induce lung adenomas in the A/J mouse lung tumor model. For 26 weeks female mice were fed a semisynthetic diet where 11 or 22% of the diet was replaced by freeze-dried mushrooms. The intake of the mushroom diets was equivalent to an intake of agaritine, the major phenylhydrazine derivative occurring in the mushroom, of 92 or 166 mg/kg body weight per day. The intake of CP was 106 mg/kg body weight per day. Neither the freeze-dried mushroom nor CP induced statistically significant increased numbers of lung adenomas in female A/J mice in the administered dosages.
Pilegaard
K
K
Institute of Toxicology, National Food Agency of Denmark, Søborg.
Kristiansen
E
E
Meyer
O A
OA
Gry
J
J
D000236:Adenoma / Q000139:chemically induced*; D000364:Agaricus; D000818:Animals; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D008805:Mice, Inbred A; D010659:Phenylhydrazines
D010659:Phenylhydrazines; C015654:agaritine