Primary Sjögren's syndrome complicated by sarcoidosis.
Sjögren's syndrome and sarcoidosis share several common features, such as keratoconjunctivitis sicca, swelling of parotid glands, lung involvement, cutaneous anergy, T cell-mediated immunodeficiency, an increased CD4+/CD8+ lymphocyte ratio, and association with the human leucocyte antigen (HLA)-B 8 and DR 3 haplotypes. However, only five patients with primary Sjögren's syndrome and sarcoidosis have been previously reported in the English language literature. The rare case of a 49-year-old Japanese woman with primary Sjögren's syndrome complicated by sarcoidosis is described. The serum angiotensin-converting enzyme level was increased, and histological examination of lung and skin biopsies revealed noncaseating granulomas, indicating that her primary Sjögren's syndrome was complicated by sarcoidosis.
Miyata
M
M
Department of Internal Medicine II, Fukushima Medical College, Hikarigaoka.
Takase
Y
Y
Kobayashi
H
H
Kokubun
M
M
Yoshimura
A
A
Katsuura
Y
Y
Nishimaki
T
T
Kasukawa
R
R
D005260:Female; D006099:Granuloma / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000473:pathology; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000201:enzymology; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis / Q000201:enzymology; D012871:Skin Diseases / Q000473:pathology
D007703:Peptidyl-Dipeptidase A