Nothramicin, a new anthracycline antibiotic from Nocardia sp. MJ896-43F17.
A new antibiotic designated nothramicin was isolated from the culture broth of Nocardia sp. MJ896-43F17 which was closely related to Nocardia brasiliensis. It was isolated by the Diaion HP-20 column chromatography, butyl acetate extraction and purified by HPLC. It inhibited the growth of mycobacteria at the concentration of 1.56 approximately 25 microg/ml. Nothramicin was revealed to be a new member of anthracycline antibiotics by the various spectroscopies.
Momose
I
I
Institute of Microbial Chemistry, Tokyo, Japan.
Kinoshita
N
N
Sawa
R
R
Naganawa
H
H
Iinuma
H
H
Hamada
M
M
Takeuchi
T
T
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009615:Nocardia
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C111762:nothramicin