[Clinical indication of propofol for pediatric patients--pharmacokinetics of propofol and ketamine during and after total intravenous anesthesia with propofol, fentanyl and ketamine (PFK) in a neonate].
A 60-day-old neonate boy received hepatic portojejunostomy for biliary atresia under PFK. Pharmacokinetics of propofol and ketamine during and after PFK was also studied. Plasma levels of propofol (Cp) and ketamine (Ck) were maintained at 2 to 3 micrograms ml-1 and at 200 to 300 ng ml-1 during surgery, respectively. Both Cp and Ck decreased quickly after the end of infusions. From the pharmacokinetic point of view, PFK may be safely applied even for neonates.
Sakai
T
T
Department of Anesthesiology, University of Hirosaki School of Medicine.
Mi
W D
WD
Komoda
Y
Y
Kudo
T
T
Kudo
M
M
Matsuki
A
A
D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics*; D001656:Biliary Atresia / Q000601:surgery; D005283:Fentanyl / Q000493:pharmacokinetics*; D006801:Humans; D007223:Infant; D007432:Intraoperative Period; D007582:Jejunostomy; D007649:Ketamine / Q000493:pharmacokinetics*; D008297:Male; D011184:Postoperative Period; D015742:Propofol / Q000493:pharmacokinetics*
D018686:Anesthetics, Intravenous; D007649:Ketamine; D005283:Fentanyl; D015742:Propofol