title: Salivary gland necrosis in dogs: a retrospective study of 19 cases.
abstract: Salivary gland necrosis has been described in dogs and is characterised by enlarged, hard, painful salivary glands, retching and vomiting or regurgitation. The cause has yet to be determined. A retrospective study of 19 dogs with the same clinical signs was undertaken for breed, age, gender, history and presenting signs, diagnostic evaluations and findings, treatment and outcome. An underlying association was identified in 16 of the 19 dogs. This included Spirocerca lupi infestation (seven dogs), megaoesophagus (three dogs) and oesophagitis, oesophageal diverticulum, giardiasis and suspected autoimmune sialadenitis. Almost all associated lesions involved the oesophagus. Where the associated disease was successfully treated, the salivary glands returned to normal and all clinical signs resolved. It is hypothesised that an afferent vagal reflex may be involved, and that the mechanism of disease is similar to the neural pathogenesis suggested for hypertrophic osteopathy; in this instance, the efferent targets are the salivary glands rather than the limbs.
authors.affiliation: Willow Park Small Animal Medicine Specialist Hospital, Pretoria, South Africa.
authors.forename: H
authors.initials: H
authors.lastname: Schroeder
authors.forename: W L
authors.initials: WL
authors.lastname: Berry
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology* / Q000628:therapy; D004285:Dogs; D005260:Female; D008297:Male; D009336:Necrosis; D012189:Retrospective Studies; D012466:Salivary Gland Diseases / Q000473:pathology / Q000628:therapy / Q000662:veterinary*