title: Corneal melting and scleromalacia perforans in a patient with pyoderma gangrenosum and acute myeloid leukemia.
abstract: Postoperative endophthalmitis may present in an atypical fashion (absent or minimal anterior chamber reaction) in the presence of underlying immunosuppressive disorder. The authors describe an apparently healthy 58-year-old man who displayed endophthalmitis with minimal anterior chamber reaction following penetrating keratoplasty for granular corneal dystrophy with underlying acute myeloid leukemia. Scleromalacia perforans in association with pyoderma gangrenosum subsequently developed, leading to ciliary staphyloma and corneal melting. Pyoderma gangrenosum is an uncommon, idiopathic skin disease that may also have ocular manifestations.
authors.affiliation: USF Eye Institute, Tampa, FL 33612-4799, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Ayyala
authors.forename: S
authors.initials: S
authors.lastname: Armstrong
mesh_terms: D000900:Anti-Bacterial Agents; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D015353:Eye Enucleation; D015818:Eye Infections, Bacterial / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015948:Keratoplasty, Penetrating / Q000009:adverse effects; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012422:Rupture, Spontaneous; D015422:Scleral Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D013211:Staphylococcus aureus / Q000302:isolation & purification; D014792:Visual Acuity
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents