Pretreatment with IFN-gamma decreases infectious complications after partial hepatectomy in the rat.
Infectious postoperative complications occur commonly after hepatectomy and may lead to a long hospital stay or death. The potential beneficial effects of interferon-gamma (IFN-gamma) in this setting were evaluated in a model of hepatectomy and sepsis in rodents. Incidence of bacterial translocation was measured in animals on days 1, 2, and 5 after partial hepatectomy. Macrophage function was quantified by in vitro tumoricidal activity and superoxide anion (O2-) production. Survival after partial hepatectomy and cecal ligation and puncture (CLP) was recorded. After partial hepatectomy, bacterial translocation was decreased on days 1 and 2 in animals pretreated with IFN-gamma (p < 0.05). Macrophages from animals treated with IFN-gamma had higher in vitro tumoricidal activity and production of O2- (p < 0.05). Hepatectomized animals pretreated with IFN-gamma had an increased survival after CLP (p < 0.05). IFN-gamma may be useful in decreasing the incidence of infectious complications after partial hepatectomy.
Blair
S L
SL
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Karpoff
H M
HM
Hodyl
C
C
Fong
Y
Y
D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control*; D002432:Cecum; D003250:Constriction; D004353:Drug Evaluation, Preclinical; D006498:Hepatectomy; D007371:Interferon-gamma / Q000627:therapeutic use*; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011677:Punctures; D051381:Rats; D011916:Rats, Inbred F344; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D007371:Interferon-gamma