Interaction of invasive bacteria with host signaling pathways.
Many bacterial pathogens exploit mammalian cell functions in order to promote their adherence to or uptake by host cells. Recent work has led to the identification of some of the bacterial and mammalian proteins involved in these processes. Although specific mechanisms differ among pathogens, a common aspect appears to be regulation of signaling pathways that control the actin cytoskeleton.
Ireton
K
K
Unité des Interactions Bactéries-Cellules, Institut Pasteur, Paris, France.
Cossart
P
P
D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D002477:Cells / Q000382:microbiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*