[Acyclic nucleotide analogues based on phosphonic acids].
The synthesis of novel nucleotide analogues on the basis of ethylphosphonic acid was described. A rigid structural element, an amide or a double bond, was characteristics of the compounds synthesized. The antiviral and cytotoxic activities of these compounds were studied in cell cultures.
Efimtseva
E V
EV
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Mikhaĭlov
S N
SN
Fomicheva
M V
MV
Meshkov
S V
SV
Rodionov
M S
MS
Khomutov
A R
AR
De Clercq
E
E
D000577:Amides; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D003587:Cytomegalovirus / Q000187:drug effects; D006367:HeLa Cells; D014645:Herpesvirus 3, Human / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009711:Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D063065:Organophosphonates / Q000737:chemistry*; D010091:Oximes; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000577:Amides; D000998:Antiviral Agents; D009711:Nucleotides; D063065:Organophosphonates; D010091:Oximes