title: [Abnormal hemoglobinopathy (HbE) diagnosed from microcytic hypochromic red blood cells in a 31 year-old Bangladeshian male].
abstract: Microcytic hypochromic red blood cells (RBC) were discovered in a 31 year-old Bangladeshi man. Additional laboratory data revealed only slight elevations of LDH and transaminase activities. The patient was clinically asymptomatic and showed no signs of anemia. On this basis, along with biochemical genetic analysis of hemoglobin, a diagnosis of hemoglobinopathy (HbE) was made. HbE is common in southeast Asia with over 30% of the population affected. Most people are asymptomatic. In northern Asia, including Japan, HbE is found in only 0.001% of the population. With ther recent influx of southeast Asians to Japan, care must be taken not to overlook the diagnosis of hemoglobinopathies.
authors.affiliation: Saitama Medical School, First Department of Internal Medicine.
authors.forename: A
authors.initials: A
authors.lastname: Handa
authors.forename: T
authors.initials: T
authors.lastname: Mibukura
authors.forename: K
authors.initials: K
authors.lastname: Aida
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Hirashima
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Harano
authors.forename: T
authors.initials: T
authors.lastname: Harano
mesh_terms: D000328:Adult; D001459:Bangladesh / Q000208:ethnology; D004912:Erythrocytes / Q000473:pathology; D006446:Hemoglobin E; D006453:Hemoglobinopathies / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007564:Japan; D008297:Male
chemical_list: D006446:Hemoglobin E