title: [Complications of polychemotherapy for renal tuberculosis].
abstract: The paper analyzes the incidence of adverse reactions caused by tuberculostatics used in the treatment of renal tuberculosis by follow-ups of 117 patients. Current polychemotherapy for renal tuberculosis has been found to be complicated by drug intolerance in 40.1% of cases. Intermittent intravenous injection of tuberculostatics causes side effects in 36.8% of patients while conventional treatment does in 59.1%. Pyrazinamide, streptomycin, and ethambutol are most toxic to patients with renal tuberculosis. There is a higher likelihood of drug intolerance in females with bilateral nephrotuberculosis complicated by chronic renal failure.
authors.forename: E V
authors.initials: EV
authors.lastname: Kul'chavenia
authors.forename: P V
authors.initials: PV
authors.lastname: Kuznetsov
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D004333:Drug Administration Routes; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011718:Pyrazinamide / Q000009:adverse effects*; D012189:Retrospective Studies; D013307:Streptomycin / Q000009:adverse effects*; D014398:Tuberculosis, Renal / Q000150:complications / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D013307:Streptomycin