title: Induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide.
abstract: In a 2-year carcinogenicity study of potassium iodide (KI) in F344/DuCrj rats, squamous cell carcinomas (SCCs) were observed in the salivary glands of 4/40 males and 3/40 females receiving 1000 ppm KI in the drinking water. Ductular proliferation with lobular atrophy was observed at high incidence in the submandibular glands of the high-dose animals, and squamous metaplasia was frequently evident within the proliferative ductules and the larger interlobular ducts. A transition from metaplasia to SCC was apparent. The results suggest that squamous metaplasia in proliferative ductules, occurring secondarily to lobular impairment induced by KI, may develop into SCCs via a non-genotoxic, proliferation-dependent mechanism.
authors.affiliation: Division of Pathology, National Institute of Health Sciences, Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Takegawa
authors.forename: K
authors.initials: K
authors.lastname: Mitsumori
authors.forename: H
authors.initials: H
authors.lastname: Onodera
authors.forename: K
authors.initials: K
authors.lastname: Yasuhara
authors.forename: K
authors.initials: K
authors.lastname: Kitaura
authors.forename: T
authors.initials: T
authors.lastname: Shimo
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D005260:Female; D008297:Male; D011193:Potassium Iodide / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012468:Salivary Gland Neoplasms / Q000150:complications* / Q000473:pathology; D014867:Water
chemical_list: D014867:Water; D011193:Potassium Iodide