[Mechanisms of distribution and elimination of perfluorocarbons upon multiple exposures].
In clinical practice much more often one meets a necessity of repeated administration of fluorocarbon blood substitutes. The 19F(-)-NMR-spectroscopy has been used to study the kinetics of the blood and tissue fluorocarbon concentration after repeated administration of PFC emulsion. Analysis of the data suggests that redistribution of PFCs between organs and blood after their repeated administration is under control of Ostwald ripening depending on PFC physicochemical properties (water and lipid solubility), emulsion particle diameter etc and does not connect with activity of reticuloendothelial system.
Sklifas
A N
AN
Institute of Cell Biophysics, Russian Academy of Science, Pushchino, Moscow Region, Russia.
Shekhtman
D G
DG
Obraztsov
V V
VV
Vorob'ev
S I
SI
Temnova
I V
IV
D000818:Animals; D005461:Fluorine; D005466:Fluorocarbons / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D005466:Fluorocarbons; D005461:Fluorine