Are the capsaicin-sensitive structures of ventral medulla involved in the temperature response to endotoxin in rats?
In chronic experiments on rats pretreated with bilateral microinjection of 25 nl 1% capsaicin to the caudal ventrolateral medulla under ketamine-xylazine-acepromazine anesthesia, an enhancement of the temperature response to intraperitoneal application of 3 microg/kg E. coli lipopolysaccharide as compared to animals who received vehicle to the caudal ventrolateral medulla was found. This is indicative of the involvement of the capsaicin-sensitive bulbar structures in thermoregulatory processes during endotoxemia.
Koulchitsky
S V
SV
Institute of Physiology, National Academy of Sciences, Minsk, Belarus, Russia. root@chel.minsk.by
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D002211:Capsaicin / Q000008:administration & dosage / Q000633:toxicity*; D019446:Endotoxemia / Q000503:physiopathology; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005246:Feedback; D007839:Functional Laterality; D008070:Lipopolysaccharides / Q000633:toxicity*; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D012881:Skin Temperature / Q000187:drug effects
D004731:Endotoxins; D008070:Lipopolysaccharides; D002211:Capsaicin