title: Multiple pigmented basal cell carcinomas.
abstract: Basal cell carcinoma is the most common of all skin cancers and the most prevalent one among Caucasians. Rarely, these tumors are seen in other races. We report a 77-year-old Korean woman who presented with multiple darkly pigmented enlarging nodules on her scalp, face, trunk, and extremities. The patient had first noted a 6-mm pigmented lesion on her left eyebrow 10 years previously. Since then, other lesions had appeared in many locations on her body. She had been otherwise healthy and without a history of exposure to arsenic or radiation. There was no family history of skin cancer, xeroderma pigmentosum, or basal cell nevus syndrome. On physical examination, multiple darkly pigmented dome-shaped papules and nodules were present on her scalp, face, right forearm, lower abdomen, and inguinal areas. They ranged in size from 0.5 mm to 2 cm. The larger ones showed central ulceration. Multiple biopsy specimens from different sites showed pigmented basal cell carcinomas. Clinically, there was no evidence of nevus sebaceus, xeroderma pigmentosum, basal cell nevus syndrome, or immunodeficiency. Clinical workup including chest radiography, abdominal ultrasound, bone scan, and brain computerized axial tomography scan did not demonstrate primary or secondary tumors. The results of serologic and hematologic tests were also within normal limits. This is an unusual case report of multiple pigmented basal cell carcinomas in an Asian woman without any predisposing risk factors.
authors.affiliation: Department of Dermatology, Boston University School of Medicine, Massachusetts 02188, USA.
authors.forename: T
authors.initials: T
authors.lastname: Shoji
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: S H
authors.initials: SH
authors.lastname: Hong
authors.forename: C H
authors.initials: CH
authors.lastname: Oh
authors.forename: W K
authors.initials: WK
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Bhawan
mesh_terms: D000368:Aged; D001706:Biopsy; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D008543:Melanins / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology*
chemical_list: D008543:Melanins