title: 4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.
authors.affiliation: Department of Medicinal Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Patane
authors.forename: A L
authors.initials: AL
authors.lastname: Scott
authors.forename: T P
authors.initials: TP
authors.lastname: Broten
authors.forename: R S
authors.initials: RS
authors.lastname: Chang
authors.forename: R W
authors.initials: RW
authors.lastname: Ransom
authors.forename: J
authors.initials: J
authors.lastname: DiSalvo
authors.forename: C
authors.initials: C
authors.lastname: Forray
authors.forename: M G
authors.initials: MG
authors.lastname: Bock
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D008297:Male; D009928:Organ Specificity; D011224:Prazosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: C547716:ADRA1B protein, human; D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; C111640:L 765314; D018340:Receptors, Adrenergic, alpha-1; C041226:Terazosin; D011224:Prazosin