Assignment of three human markers in chromosome 21q11 to mouse chromosome 16.
Three unique sequence microclones from human chromosome region 21q11 were assigned to mouse chromosome 16 using a mouse/Chinese hamster cell hybrid 96Az2 containing a single mouse chromosome 16. This comparative mapping provides further homology between human chromosome 21 and mouse chromosome 16 to include the very proximal portion of the long arm of human chromosome 21. Since this part of human chromosome 21 is associated with mental retardation in Down syndrome individuals, its homologous mouse region should also be included in the construction of mouse models for studying Down syndrome phenotypes including mental retardation.
Yu
J
J
Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206, USA.
Shen
Y
Y
Tong
S
S
Kao
F T
FT
D000818:Animals; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics* / Q000648:ultrastructure; D003001:Cloning, Molecular; D006224:Cricetinae; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000235:genetics; D015723:Gene Library; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008607:Intellectual Disability / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D010641:Phenotype; D013045:Species Specificity
D005819:Genetic Markers