Urinary metabolites of valproic acid in epileptic patients.
The urinary excretion of valproic acid (VPA) and its metabolites (3-keto VPA, 3-OH VPA, and VPA-glucuronide) in 6 epileptic patients was studied using gas chromatography-mass spectrometry. The amount of VPA and 3-OH VPA excreted in the urine was low (0.1-0.5% of the dose of VPA and 0.6-1.5% of the dose of 3-OH administered). The amount of 3-keto VPA and glucuronide (VPA-Glu) excreted was marked (5.8-26.2% and 13.1-88.7% of the dose of VPA administered, respectively). The urinary excretion of VPA and its metabolites by patients who have taken a normal amount of a VPA preparation was almost the same as that of healthy volunteers. Two epileptic patients who took a large amount of the VPA preparation showed a high excretion of VPA-Glu without an increase in their plasma VPA-Glu.
Katayama
H
H
Fukuyama University, Faculty of Pharmacy and Pharmaceutical Sciences, Hiroshima, Japan.
Watanabe
M
M
Yoshitomi
H
H
Yoshida
H
H
Kimoto
H
H
Kamiya
A
A
Hayashi
T
T
Akimura
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000097:blood / Q000627:therapeutic use / Q000652:urine*; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy / Q000652:urine*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D014635:Valproic Acid / Q000097:blood / Q000627:therapeutic use / Q000652:urine*
D000927:Anticonvulsants; D014635:Valproic Acid