title: No association of apolipoprotein epsilon 4 allele with schizophrenia even in cognitively impaired patients.
abstract: Given the strong association of the apolipoprotein E (apoE) allele epsilon 4 (epsilon 4) with Alzheimer's disease or cognitive decline in elderly, we tested whether cognitive performance in schizophrenic subjects is associated with an increase in the frequency of the ApoE epsilon 4 allele. Our data indicate that in our sample: (1) there is no association between schizophrenia and the ApoE epsilon 4 allele; and (2) the ApoE epsilon 4 allele is not of major importance with regard to the cognitive decline observed in schizophrenia.
authors.affiliation: Groupe de Recherche Psychopathologie et Schizophrenies (JE 2014), Universites de Medecine de Rouen et Caen, France.
authors.forename: F
authors.initials: F
authors.lastname: Thibaut
authors.forename: B
authors.initials: B
authors.lastname: Coron
authors.forename: D
authors.initials: D
authors.lastname: Hannequin
authors.forename: L
authors.initials: L
authors.lastname: Segard
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: S
authors.initials: S
authors.lastname: Dollfus
authors.forename: D
authors.initials: D
authors.lastname: Campion
authors.forename: T
authors.initials: T
authors.lastname: Frebourg
authors.forename: M
authors.initials: M
authors.lastname: Petit
mesh_terms: D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*; D012565:Schizophrenic Psychology; D014888:Wechsler Scales
chemical_list: D001057:Apolipoproteins E; D005819:Genetic Markers