Cremimycin, a novel 19-membered macrocyclic lactam antibiotic, from Streptomyces sp.
A novel 19-membered macrocyclic lactam antibiotic, cremimycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MJ635-86F5, was identified as a member of Streptomyces. Cremimycin was isolated from the mycelial cake by extraction with CHCl3-MeOH and precipitation with hexane-MeOH. The structure of cremimycin was determined by spectroscopic study. Cremimycin showed broad antimicrobial activities against Gram-positive bacteria including MRSA.
Igarashi
M
M
Institute of Microbial Chemistry, Tokyo, Japan.
Tsuchida
T
T
Kinoshita
N
N
Kamijima
M
M
Sawa
R
R
Sawa
T
T
Naganawa
H
H
Hamada
M
M
Takeuchi
T
T
Yamazaki
K
K
Ishizuka
M
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007769:Lactams; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013302:Streptomyces; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007769:Lactams