Exercise-induced hormone responses in girls at different stages of sexual maturation.
The dependence of exercise-induced hormone responses on sexual maturation was tested in a 3-year longitudinal experiment on 34 girls (aged 11-12 years at the beginning). Sexual maturation was evaluated by Tanners five-stage scale. Children cycled for 20-min at 60% maximal oxygen uptake once a year. Cortisol, insulin, growth hormone, beta-oestradiol, progesterone and testosterone concentrations in venous blood were determined by radioimmunoassay procedures. Basal concentrations of growth hormone increased and of cortisol decreased when breast stage III was reached. Reaching breast stage IV was associated with an increase in basal concentrations of beta-oestradiol, progesterone and testosterone. The exercise induced significant increases in concentrations of cortisol, growth hormone and beta-oestradiol and a decrease in insulin concentration. At breast stage III the increase in cortisol concentration was to a lower level [467 (SEM 42) vs 567 (SEM 46)nmol x l(-1)] and growth hormone concentration to a higher level [29.4 (SEM 0.5) vs 12.8 (SEM 0.4)ng x ml(-1)], while the fall in insulin concentration was less pronounced [postexercise level 10.6 (SEM 0.9) vs 7.8 (SEM 0.8)mU x l(-1)] than in stage II. The magnitude of the cortisol response was reduced in the last stage of breast development (+42.1% vs +55.5% at stage II, +66.2% at stage III, and +50.0% at stage IV). The magnitude of beta-oestradiol response was the lowest in breast stage IV (+15.8%) and the highest at stage V (+41.1%). The progesterone response became significant at stage IV and testosterone response at stage V. In conclusion, we found that reaching breast stage III was associated with altered responses of cortisol, insulin and growth hormone concentrations while the responses of the sex hormone concentrations became pronounced in the last stages of sexual maturation.
Viru
A
A
Institute of Exercise Biology, University of Tartu, Estonia.
Laaneots
L
L
Karelson
K
K
Smirnova
T
T
Viru
M
M
D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006728:Hormones / Q000097:blood*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008137:Longitudinal Studies; D011374:Progesterone / Q000097:blood; D011627:Puberty / Q000502:physiology; D012741:Sexual Maturation / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D006728:Hormones; D007328:Insulin; D019382:Human Growth Hormone; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D006854:Hydrocortisone