Effect of angiotensin infusion on plasma endothelin in pregnancy.
OBJECTIVE
To study a possible role of plasma endothelin in angiotensin-induced vasoconstriction.


METHODS
Plasma endothelin levels were measured before and after an angiotensin sensitivity test at 32 gestational weeks in 19 nulliparous women.


RESULTS
No significant change in plasma endothelin occurred as a result of angiotensin infusion.


CONCLUSIONS
The angiotensin-induced rise in diastolic blood pressure is not associated with changes in plasma endothelin.
Delemarre
F M
FM
Department of Obstetrics and Gynecology, Catharina Hospital Eindhoven, The Netherlands.
de Jong
D
D
Didden
M A
MA
de Jong
P A
PA
D000328:Adult; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D019332:Endothelin-1 / Q000097:blood* / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D011247:Pregnancy / Q000097:blood* / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*
D019332:Endothelin-1; D014662:Vasoconstrictor Agents; D000804:Angiotensin II