title: Calcium dobesilate increased endothelium-dependent relaxation in isolated rabbit aorta.
abstract: 1. The aim of this study was to investigate the effects of calcium dobesilate on relaxant and contractile responses in the isolated rabbit aorta. 2. Calcium dobesilate (10(-6) and 10(-4) M) shifted the concentration-response curve induced by noradrenaline (10(-8)-10(-4) M) downward and to the right, the IC50 being 5.1 +/- 1.1 x 10(-7) M in the control and 7.5 +/- 1.2 x 10(-6) M and 3.1 +/- 1.9 x 10(-6) M in the presence of calcium dobesilate, 10(-6) M and 10(-4) M respectively. 3. Calcium dobesilate, 10(-5) M, increased the endothelium-dependent relaxation induced by acetylcholine (10(-8)-10(-5) M) but had no actions in the absence of endothelium.
authors.affiliation: Department of Pharmacology, School of Medicine, Complutense University, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Ruiz
authors.forename: T
authors.initials: T
authors.lastname: Tejerina
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects; D002123:Calcium Dobesilate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D006490:Hemostatics / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010396:Penicillamine / Q000031:analogs & derivatives / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D006490:Hemostatics; C110881:S-nitro-N-acetylpenicillamine; D014662:Vasoconstrictor Agents; D012701:Serotonin; D002123:Calcium Dobesilate; D011189:Potassium Chloride; D006632:Histamine; D010396:Penicillamine; D009638:Norepinephrine