Miconazole as inflammatory agent. II: Time course of pleurisy and drug interference.
1. Miconazole-induced pleurisy was characterized by edema development and leukocyte infiltration. 2. This response was inhibited by chlorpheniramine, methysergide and steroidal and nonsteroidal anti-inflammatory drugs. 3. After miconazole injection, no mast cells were found in the pleural cavity. 4. Our results support the concept that biogenic amines released from mast cells and cyclooxygenase-derived mediators may contribute to the pathogenesis and evolution of miconazole inflammation.
Hanada
S
S
Department of Pharmacology, Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
Sugawara
S H
SH
Sertié
J A
JA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000009:adverse effects / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D008825:Miconazole / Q000009:adverse effects / Q000494:pharmacology*; D010998:Pleurisy / Q000139:chemically induced* / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D008825:Miconazole