The effect of haloperidol on the histaminergic neuron system in the rat brain.
In this study, the effect of haloperidol on histamine (HA) levels, histidine decarboxylase (HDC) activities and the bindings of [3H]-(R)-alpha-methylhistamine ([3H]-(R)-alpha-MeHA) to histamine H3 receptors were investigated in the rat brain. Administration of 10 mg/kg of haloperidol decreased HA levels in the rat striatum and diencephalon, but increased HDC activities in rat striatum and diencephalon, although that of 5 mg/kg did not change them. Meanwhile, haloperidol inhibited the bindings of [3H]-(R)-alpha-MeHA to H3 receptor sites in the rat striatal membrane with a Ki value of 10.5 +/- 0.45 microM. These findings suggest that only a high dose of haloperidol increases HA synthesis and release as a histamine H3 receptor antagonist in the rat brain.
Ito
C
C
Department of Psychiatry, Tohoku University School of Medicine, Sendai, Japan. cito@mail.cc.tohoku.ac.jp
Onodera
K
K
Yamatodani
A
A
Yanai
K
K
Sakurai
E
E
Sato
M
M
Watanabe
T
T
D000818:Animals; D001921:Brain / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D006220:Haloperidol / Q000494:pharmacology*; D006632:Histamine / Q000378:metabolism / Q000502:physiology*; D017442:Histamine Agonists / Q000378:metabolism; D006640:Histidine Decarboxylase / Q000378:metabolism; D008761:Methylhistamines / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017442:Histamine Agonists; D008761:Methylhistamines; C069357:alpha-methylhistamine; D006632:Histamine; D006640:Histidine Decarboxylase; D006220:Haloperidol