title: Failure of the cultivated mushroom (Agaricus bisporus) to induce tumors in the A/J mouse lung tumor model.
abstract: We studied whether the cultivated mushroom (Agaricus bisporus) or 4-(carboxy)phenylhydrazine (CP) induce lung adenomas in the A/J mouse lung tumor model. For 26 weeks female mice were fed a semisynthetic diet where 11 or 22% of the diet was replaced by freeze-dried mushrooms. The intake of the mushroom diets was equivalent to an intake of agaritine, the major phenylhydrazine derivative occurring in the mushroom, of 92 or 166 mg/kg body weight per day. The intake of CP was 106 mg/kg body weight per day. Neither the freeze-dried mushroom nor CP induced statistically significant increased numbers of lung adenomas in female A/J mice in the administered dosages.
authors.affiliation: Institute of Toxicology, National Food Agency of Denmark, Søborg.
authors.forename: K
authors.initials: K
authors.lastname: Pilegaard
authors.forename: E
authors.initials: E
authors.lastname: Kristiansen
authors.forename: O A
authors.initials: OA
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Gry
mesh_terms: D000236:Adenoma / Q000139:chemically induced*; D000364:Agaricus; D000818:Animals; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D008805:Mice, Inbred A; D010659:Phenylhydrazines
chemical_list: D010659:Phenylhydrazines; C015654:agaritine