title: Post-lesion up-regulation of 5-HT1B binding sites in the suprachiasmatic nucleus may be reversed after spontaneous or graft-induced serotonin reinnervation.
abstract: We have previously reported that selective axotomy of serotoninergic neurons produced by an intraventricular injection of 5, 7-dihydroxytryptamine is followed by an increase in 5-HT1B binding sites in the suprachiasmatic nucleus of the hypothalamus. This post-lesion up-regulation is shown here to be spontaneously reversed after long-term survival in spite of an incomplete reinnervation of the nucleus. Recovery may be accelerated by fetal raphe transplants that produce more rapid reinnervation.
authors.affiliation: Laboratoire de Neuroendocrinologie Expérimentale, INSERM U297, Institut Fédératif Jean Roche, Faculté de Médecine Nord, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France.
authors.forename: C
authors.initials: C
authors.lastname: Manrique
authors.forename: O
authors.initials: O
authors.lastname: Bosler
authors.forename: D
authors.initials: D
authors.lastname: Becquet
authors.forename: F
authors.initials: F
authors.lastname: Héry
authors.forename: M
authors.initials: M
authors.lastname: Faudon
authors.forename: A M
authors.initials: AM
authors.lastname: François-Bellan
mesh_terms: D000818:Animals; D016332:Fetal Tissue Transplantation; D007276:Injections, Intraventricular; D008297:Male; D009474:Neurons / Q000502:physiology; D011903:Raphe Nuclei / Q000196:embryology / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000502:physiology*; D015854:Up-Regulation
chemical_list: D011985:Receptors, Serotonin