title: Dietary fatty acids alter the adhesion properties of lymphocytes to extracellular matrix proteins.
abstract: Dietary fats have been shown by many investigators to affect immune responses in vitro and in vivo. However, the exact mechanism(s) by which fats or their metabolic derivatives affect immune function is still unknown. In this report we have investigated whether short-term in vitro exposure to fatty acids alters the adhesion of lymphocytes to extracellular matrix proteins. We found remarkably heterogeneous effects with these agents on lymphocyte adhesion; increases and decreases in adhesion were observed depending upon the fatty acid, cell type and extracellular matrix protein used. Alterations in the adhesion potential of lymphocytes could serve as a mechanism for the reported effects of fatty acids on immune function since lymphocytes are dependent upon rapid and reversible adherence events for most of their effector activities.
authors.affiliation: Department of Molecular Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
authors.forename: F D
authors.initials: FD
authors.lastname: Stephen
authors.forename: R J
authors.initials: RJ
authors.lastname: Kelleher
authors.forename: M
authors.initials: M
authors.lastname: Langner
authors.forename: E A
authors.initials: EA
authors.lastname: Repasky
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000502:physiology*; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D003094:Collagen / Q000502:physiology; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D005260:Female; D005353:Fibronectins / Q000502:physiology; D007797:Laminin / Q000502:physiology; D008560:Membrane Fluidity / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology*
chemical_list: D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D016326:Extracellular Matrix Proteins; D005230:Fatty Acids, Nonesterified; D005353:Fibronectins; D007797:Laminin; D003094:Collagen