title: Using information from both parents when testing for association between marker and disease loci.
abstract: Several extensions of the transmission/disequilibrium test (TDT) to multi-allelic markers now exist. In some of these, however, separate tests must be performed on male and female parents because of the non-independence of parental transmission patterns, reducing power, and complicating interpretation of the test results. Here we show that this non-independence is asymptotically irrelevant when using the allelic TDT of Bickeböller and Clerget-Darpoux [(1995) Genet Epidemiol 12:577-582], allowing the analysis of data from both parents simultaneously.
authors.affiliation: Department of Applied Statistics, University of Reading, UK. j.c.whittaker@reading.ac.uk
authors.forename: J C
authors.initials: JC
authors.lastname: Whittaker
authors.forename: A P
authors.initials: AP
authors.lastname: Morris
authors.forename: R N
authors.initials: RN
authors.lastname: Curnow
mesh_terms: D000483:Alleles; D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010290:Parents
chemical_list: D005819:Genetic Markers