Vanadyl treatment normalizes submandibular salivary gland insulin-like immunoreactivity in streptozotocin-diabetic rats.
Rat submandibular salivary glands (SSG) contain a compound displaying insulin-like immunoreactivity (ILI) and various biological activities of insulin. As SSG ILI levels were reported to be increased in streptozotocin (STZ)-induced diabetes but not normalized by a two-week insulin treatment, we decided to check whether another antidiabetic treatment, vanadyl sulphate (VOSO4), was able to regulate SSG ILI concentration. A short term (8 days) i.p. VOSO4 treatment (total dose = 1.3 mmol/kg) of rats made diabetic 8 days earlier by a single i.v. injection of STZ (60 mg/kg BW) was able to induce a long-term (4 weeks) correction of hyperglycemia while weight gain was re-established. In untreated diabetic animals (approximately -25%) and increased (approximately +175%) as compared to normal rats. Both parameters were normalized in VOSO4-treated diabetic rats.
Deville de Périère
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Laboratoire de Physiologie, Faculté d'Odontologie, Montpellier, France.
Poucheret
P
P
Egea
J C
JC
Gross
R
R
Masiello
P
P
Cros
G
G
Serrano
J J
JJ
Ribes
G
G
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013363:Submandibular Gland / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism*; D017968:Vanadium Compounds / Q000627:therapeutic use*
D007004:Hypoglycemic Agents; D007328:Insulin; D017968:Vanadium Compounds; C034028:vanadyl sulfate