Transcription factors that regulate monocyte/macrophage differentiation.
Although all the cells in an organism contain the same genetic information, differences in the cell phenotype arise from the expression of lineage-specific genes. During myelopoiesis, external differentiating signals regulate the expression of a set of transcription factors. The combined action of these transcription factors subsequently determines the expression of myeloid-specific genes and the generation of monocytes and macrophages. In particular, the transcription factor PU.1 has a critical role in this process. We review the contribution of several transcription factors to the control of macrophage development.
Valledor
A F
AF
Departament de Fisiologia (Immunologia), Facultat de Biologia and Fundació August Pi i Sunyer, Universitat de Barcelona, Spain.
Borràs
F E
FE
Cullell-Young
M
M
Celada
A
A
D000818:Animals; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D019891:Leukopoiesis; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology; D013234:Stem Cells / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*; D016335:Zinc Fingers / Q000502:physiology; D000099232:Proto-Oncogene Protein Spi-1
D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000099232:Proto-Oncogene Protein Spi-1