Splenic lymphoma with villous lymphocytes showing del(7) and inv(10).
A 49-year-old woman presented with splenic lymphoma with villous lymphocytes (SLVL) that showed a clonal abnormality of del(7)(q22q32) in addition to inv(10)(p13q23), the latter being a previously undescribed abnormality in chronic lymphoproliferative disorders. A review of the literature on cytogenetic abnormalities of SLVL indicates that del(7q) is strongly associated with SLVL and may be important in the pathogenesis of this disorder.
Wong
K F
KF
Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China.
Chu
Y C
YC
Hui
P K
PK
D002872:Chromosome Deletion; D007446:Chromosome Inversion; D002879:Chromosomes, Human, Pair 10; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000648:ultrastructure; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000235:genetics* / Q000648:ultrastructure