Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology.
The present report reviews recent advances in mapping the cellular sites of synthesis and catalytic activity, as well as age- and disease-related changes of monoamine oxidases A and B in the brain. A transgenic model of oxidative stress is also described. The relevance of these findings for the physiological and pathophysiological roles of monoamine oxidases is briefly discussed.
Richards
J G
JG
Pharmaceuticals Division, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Saura
J
J
Luque
J M
JM
Cesura
A M
AM
Gottowik
J
J
Malherbe
P
P
Borroni
E
E
Gray
J
J
D000544:Alzheimer Disease / Q000201:enzymology; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000502:physiology* / Q000503:physiopathology; D001931:Brain Mapping; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008995:Monoamine Oxidase / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000201:enzymology; D051381:Rats
D005609:Free Radicals; D007527:Isoenzymes; D008995:Monoamine Oxidase