Cyclosporin A and FK-506 inhibit development of superantigen-potentiated collagen-induced arthritis in mice.
1. Staphylococcal enterotoxine B (SEB; superantigen) accelerated the onset of arthritis in mice preimmunized with type II collagen (SEB-potentiated collagen-induced arthritis). Cyclosporin A and FK-506 inhibited the induction and development of clinical signs and histopathological changes of SEB-potentiated collagen-induced arthritis in mice. 2. Simultaneously, both cyclosporin A and FK-506 inhibited the development of humoral and cellular immunity to type II collagen. 3. The expression of IL-2 receptor (CD25) by SEB on splenocyte T cells from collagen-preimmunized mice was inhibited by both agents in ex vivo experimentation.
Takaoka
Y
Y
Department of Pharmacology, Gifu Pharmaceutical University, Japan.
Nagai
H
H
Tanahashi
M
M
Kawada
K
K
D000818:Animals; D018501:Antirheumatic Agents / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000517:prevention & control*; D003094:Collagen; D016572:Cyclosporine / Q000494:pharmacology*; D004768:Enterotoxins; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D015375:Receptors, Interleukin-2 / Q000187:drug effects / Q000378:metabolism; D018089:Superantigens; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology; D016559:Tacrolimus / Q000494:pharmacology*
D018501:Antirheumatic Agents; D004768:Enterotoxins; D007166:Immunosuppressive Agents; D015375:Receptors, Interleukin-2; D018089:Superantigens; C031818:enterotoxin B, staphylococcal; D016572:Cyclosporine; D003094:Collagen; D016559:Tacrolimus