title: Short column gas chromatography-mass spectrometry and principal component analysis for the identification of coeluted substances in doping control analysis.
abstract: The identification of four doping control substances in an artificial mixture, using short column gas chromatography-mass spectrometry (GC-MS) analysis was examined. Two chromatographic peaks were recorded in the chromatogram, using a short capillary column (1.8 m) at an oven temperature of 180 degrees C. The first peak was associated with a mixture of a solvent derivative and an artifact. The second one corresponded to the mixture of four control substances. Principal component analysis was applied on a selected GC-MS data set of the latter peak to determine clear full spectra of pure substances from mixture spectra. The time of GC-MS analysis was significantly reduced to less than 1 min from 30 min which is a typical GC-MS analysis time, using standard methods of doping control analysis.
authors.affiliation: National Technical University of Athens, Department of Chemical Engineering, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Statheropoulos
authors.forename: N
authors.initials: N
authors.lastname: Tzamtzis
authors.forename: K
authors.initials: K
authors.lastname: Mikedi
mesh_terms: D003042:Cocaine / Q000032:analysis; D003915:Dextromethorphan / Q000032:analysis; D011431:Dextropropoxyphene / Q000032:analysis; D005163:Factor Analysis, Statistical; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D008691:Methadone / Q000032:analysis; D009294:Narcotics / Q000032:analysis*; D012984:Software; D015813:Substance Abuse Detection / Q000379:methods*; D013997:Time Factors
chemical_list: D009294:Narcotics; D003915:Dextromethorphan; D003042:Cocaine; D011431:Dextropropoxyphene; D008691:Methadone