The preprotein translocase of the mitochondrial outer membrane.
The translocase components of the mitochondrial outer membrane (Tom) are essential for the transfer of preproteins from the cytosol to the mitochondria. At least nine Tom components have now been identified and they fall into two categories; receptor components and components of the General Import Pore (GIP). The receptor components most likely diffuse laterally in the membrane and deposit preproteins atthe GIP where they are then inserted into the mitochondria. This review focuses on these components and their known interactions in the process of preprotein translocation.
Ryan
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MT
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Germany.
Pfanner
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D000251:Adenosine Triphosphatases / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D001692:Biological Transport; D003600:Cytosol / Q000201:enzymology; D029968:Escherichia coli Proteins; D007425:Intracellular Membranes / Q000201:enzymology*; D026901:Membrane Transport Proteins; D008928:Mitochondria / Q000201:enzymology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D000069816:SEC Translocation Channels; D000081416:SecA Proteins
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D000069816:SEC Translocation Channels; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins