title: Evaluation of culture, histological examination, serology and the rapid urease test for diagnosis of Helicobacter pylori in patients with dyspepsia in Bangladesh.
abstract: Helicobacter pylori, a gram-negative, microaerophilic bacterium, has been established to have a causal association with chronic gastritis, peptic ulcer, gastric adenocarcinoma, and low-grade lymphoma. The present study was undertaken to evaluate the efficacy of culture, histological examination, the rapid urease test, and serology for the diagnosis of H. pylori infection. A total of 45 consecutive subjects with various upper gastrointestinal symptoms were included in this study. The rates of diagnosis of H. pylori infection were 51.1%, 55.6%, 82.2%, and 93.3%, by culture, rapid urease test (RUT), histological examination, and serology, respectively. The sensitivity, specificity, and positive and negative predictive values were 95.5%, 82.6%, 84.0%, and 95.0%, respectively for RUT; 95.5%, 30.4%, 56.8%, and 87.5% for histological examination; 100%, 13.6%, 54.8% and 100% for serology.
authors.affiliation: Institute of Life Sciences, Jahangirnagar University, Savar, Dhaka, Bangladesh.
authors.forename: M G
authors.initials: MG
authors.lastname: Morshed
authors.forename: F
authors.initials: F
authors.lastname: Jinnah
authors.forename: M S
authors.initials: MS
authors.lastname: Islam
authors.forename: M A
authors.initials: MA
authors.lastname: Rumi
authors.forename: S
authors.initials: S
authors.lastname: Ahmed
authors.forename: M M
authors.initials: MM
authors.lastname: Ahmed
authors.forename: M
authors.initials: M
authors.lastname: Sadeque
authors.forename: M F
authors.initials: MF
authors.lastname: Chowdhury
mesh_terms: D000328:Adult; D000368:Aged; D001459:Bangladesh; D004415:Dyspepsia / Q000150:complications*; D005069:Evaluation Studies as Topic; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000201:enzymology / Q000302:isolation & purification; D006652:Histological Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D014510:Urease / Q000032:analysis
chemical_list: D014510:Urease