title: A convenient and efficient synthesis of sialyl Lewis X.
abstract: A convenient synthesis of the sialyl Lewis X (sLe(x)) tetrasaccharide, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc (8), as a carbohydrate ligand for selectins is described. The key step is the reaction between NeuAc alpha 2-3GalSMe (5) as a glycosyl donor and the suitably protected Fuc alpha 1-3GlcNAc derivative (4) as the glycosyl acceptor by using dimethyl(methylthio)sulfonium triflate (DMTST) as the promoter.
authors.affiliation: Drug Discovery Research Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd., Mie, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Baba
authors.forename: N
authors.initials: N
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Hamajima
authors.forename: T
authors.initials: T
authors.lastname: Ikami
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: A
authors.initials: A
authors.lastname: Hasegawa
authors.forename: M
authors.initials: M
authors.lastname: Kiso
mesh_terms: D002240:Carbohydrate Sequence; D006031:Glycosylation; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis*; D000080506:Sialyl Lewis X Antigen
chemical_list: D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen