New metabolites from the sponge Spongia agaricina.
The sponge Spongia agaricina from Tarifa, Cadiz, Spain, contains two new 9,11-secosterols, [3-0-deacetylluffasterol B (1) and 3-0-deacetyl-22,23-dihydro-24,28-dehydroluffasterol B (2)] and two new sesterterpenoids [12,16-di-epi-12-0-deacetyl-16-0-acetylfuroscalarol (3) and 16-epi-scalarolbutenolide (4)], in addition to the known compounds 5-15. The structures of all compounds were elucidated by interpretation of' spectroscopic data. The metabolites 1-3 showed significant cytotoxicity against four tumor cell lines (C50 1 microgram/mL).
Rueda
A
A
Departamento de Química Orgánica, Facultad de Ciencias del Mar, Universidad de Cádiz, Spain.
Zubía
E
E
Ortega
M J
MJ
Carballo
J L
JL
Salvá
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000302:isolation & purification* / Q000494:pharmacology; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013261:Sterols; D013729:Terpenes