[Fibronectin and the human spleen].
Fibronectins are glycoproteins with a function of molecular glue. The aim of the study is to encourage interest in processes in extracellular matrix of the spleen. Undigested cryostat or formol-paraffin sections and commercially available antibodies were used. We were mostly successful in extracellular localization of fibronectin in trabeculae, vessel walls and lamellae of circumferent reticulum of periarterial lymphatic sheaths and in the ring fibres of the sinuses. Changes in the amount of fibronectin occurred, for example, in circulation disturbances. In hereditary spherocytosis the ring fibres were reduced. Increase of fibronectin can suggest the development of fibrosis.
Sidlo
J
J
Ustav patologickej anatómie LF UK a FN, Bratislava.
Jakubovský
J
J
Porubský
J
J
Danihel
L
L
Holeczy
P
P
Papincák
J
J
Mistrík
M
M
Holesa
S
S
Durdík
S
S
D005109:Extracellular Matrix / Q000737:chemistry*; D005353:Fibronectins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D013154:Spleen / Q000737:chemistry*
D005353:Fibronectins