To what extent do premenstrual and interictal dysphoric disorder overlap? Significance for therapy.
BACKGROUND
Premenstrual dysphoria has shown a significant relationship to epilepsy, and its symptoms correspond to those of the interictal dysphoric disorder. The established treatment for interictal dysphoric disorder is explored as an effective treatment for premenstrual dysphoria.


METHODS
Women with premenstrual dysphoria (the majority with epilepsy) were evaluated and treated systematically.


RESULTS
Premenstrual disorder responded well to the combination of antidepressant and antiepileptic medication.


CONCLUSIONS
Concordance of symptomatology between interictal and premenstrual dysphoric disorder may extend to treatment.


CONCLUSIONS
The treatment needs to be evaluated in a large series of women without epilepsy.


CONCLUSIONS
A novel understanding and treatment of premenstrual dysphoria is suggested.
Blumer
D
D
Department of Psychiatry, University of Tennessee, Memphis 38103, USA.
Herzog
A G
AG
Himmelhoch
J
J
Salgueiro
C A
CA
Ling
F W
FW
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D002648:Child; D003863:Depression / Q000188:drug therapy* / Q000209:etiology*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007508:Irritable Mood / Q000187:drug effects; D011293:Premenstrual Syndrome / Q000150:complications* / Q000188:drug therapy; D012008:Recurrence; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D017367:Selective Serotonin Reuptake Inhibitors; D014635:Valproic Acid