Ticlopidine-induced neutropenia mimicking sepsis early after intracoronary stent placement.
We report a case of ticlopidine-induced profound neutropenia early in the course of therapy, which was manifest as a febrile systemic illness mimicking sepsis. This clinical presentation was potentially indicative of a contaminated intracoronary stent. The patient's signs and symptoms of illness promptly resolved with removal of ticlopidine, and no infection was documented. Review of indications for ticlopidine use, potential adverse effects, and monitoring recommendations are discussed.
Ochoa
A B
AB
Wright-Patterson Medical Center, Department of Internal Medicine, Wright-Patterson Air Force Base, OH 45433, USA.
Wolfe
M
M
Lewis
P
P
Lenihan
D J
DJ
D017023:Coronary Angiography; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D018805:Sepsis / Q000150:complications* / Q000175:diagnosis; D015607:Stents; D013988:Ticlopidine / Q000009:adverse effects*
D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine