Midkine exists in astrocytes in the early stage of cerebral infarction.
Midkine (MK), a heparin-binding neurotrophic factor, is expressed in the early stage of experimental cerebral infarction in the zone surrounding the infarct. Double immunostaining with anti-MK and anti-glial fibrillary acidic protein showed existence of MK in astrocytic cytoplasm on postoperative day 2. Immunoelectron microscopic analysis revealed the presence of MK in the swollen astrocytic processes on postoperative day 4.
Wang
S
S
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
Yoshida
Y
Y
Goto
M
M
Moritoyo
T
T
Tsutsui
J
J
Izumo
S
S
Sato
E
E
Muramatsu
T
T
Osame
M
M
D000208:Acute Disease; D000818:Animals; D001253:Astrocytes / Q000737:chemistry*; D002352:Carrier Proteins / Q000032:analysis*; D002544:Cerebral Infarction / Q000378:metabolism* / Q000473:pathology; D016207:Cytokines; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007150:Immunohistochemistry; D000078792:Midkine; D009414:Nerve Growth Factors / Q000032:analysis*; D051381:Rats
D002352:Carrier Proteins; D016207:Cytokines; D005904:Glial Fibrillary Acidic Protein; D009414:Nerve Growth Factors; D000078792:Midkine