title: Phenytoin-induced thrombocytopenia treated with intravenous immune globulin.
abstract: OBJECTIVE
  To describe the use of intravenous immune globulin (IVIG) in an 8-year-old girl with phenytoin-induced thrombocytopenia and leukopenia.
  
  
  METHODS
  An 8-year-old girl had fever, rash, thrombocytopenia, and leukopenia 18 days after initiation of phenytoin therapy. The phenytoin level was elevated. She was treated with 1 g/kg of IVIG.
  
  
  RESULTS
  The thrombocytopenia improved dramatically after IVIG therapy. There was a slower response to the leukopenia.
  
  
  CONCLUSIONS
  Phenytoin hypersensitivity can present with thrombocytopenia and leukopenia. Treatment with IVIG was associated with a rapid rise in the platelet count in the patient in this report. IVIG should be considered for patients with phenytoin-induced thrombocytopenia.
authors.affiliation: Department of Pediatrics, Kaiser Permanente West Los Angeles Medical Center, CA 90034, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Salzman
authors.forename: E M
authors.initials: EM
authors.lastname: Smith
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007970:Leukopenia / Q000139:chemically induced / Q000188:drug therapy; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D016756:Immunoglobulins, Intravenous; D010672:Phenytoin