Genetically modified mice for the study of apolipoprotein B.
Over the past five years, several laboratories have used a variety of transgenic and gene-targeted mice to study apoB. These studies have helped in 1) generating new mouse models suitable for investigating the genetic and environmental factors affecting atherogenesis; 2) providing systems for investigating apoB structure/function relationships; 3) understanding the regulation of apoB gene expression in the intestine; 4) delineating a critical role for apoB expression in mouse embryonic development; 5) yielding insights into the "physiologic rationale" for the existence of the two different forms of apoB, apoB-48 and apoB-100, in mammalian metabolism; and 6) providing basic insights into mechanisms involved in the human apoB deficiency syndrome, familial hypobetalipoproteinemia.
Kim
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Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-9100, USA.
Young
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SG
D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics* / Q000378:metabolism; D001161:Arteriosclerosis / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice / Q000235:genetics*; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009154:Mutation; D011973:Receptors, LDL / Q000378:metabolism
D001055:Apolipoproteins B; D011973:Receptors, LDL