title: [Axillary hyperhidrosis: successful treatment with botulinum toxin A].
abstract: Severe hyperhidrosis may present as a vexing condition for the patient and a therapeutic challenge for the physician. As botulinum toxin-A (BT-A) can potently block cholinergic sympathic innervation of sweat glands it was used in an open trial for controlling severe axillary hyperhidrosis. After visualization of hyperhidrosis using the iodine-starch-test BT-A (Dysport, 400 Units) was injected intradermally in one axilla. One week later gravimetric quantification of sweat secretion revealed a reduction of sweating to 4-9% of initial values. In order to rule out daily variations as well as other factors interfering with sweat production BT-A treatment was restricted to only one axilla in each individual clearly demonstrating extensive anhidrotic efficacy on the treated side only. The treatment was well tolerated without side-effects and was assessed as 'completely satisfying' by all patients. BT-A may offer a fast, safe and highly effective therapeutic option for severe hyperhidrosis.
authors.affiliation: Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.
authors.forename: M
authors.initials: M
authors.lastname: Heckmann
authors.forename: S
authors.initials: S
authors.lastname: Breit
authors.forename: A
authors.initials: A
authors.lastname: Ceballos-Baumann
authors.forename: M
authors.initials: M
authors.lastname: Schaller
authors.forename: G
authors.initials: G
authors.lastname: Plewig
mesh_terms: D000293:Adolescent; D000328:Adult; D001365:Axilla / Q000294:innervation; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy* / Q000209:etiology; D007271:Injections, Intradermal; D008297:Male; D017060:Patient Satisfaction; D013546:Sweating / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects
chemical_list: D019274:Botulinum Toxins, Type A