[Recurrent urinary tract infections. Biological suppositions and clinical treatment with thymopentin].
BACKGROUND
Urinary tract infections (UTI) are a common usual pathological event. They relapse often due to the periurethral colonization of microorganisms from the intestinal bacterial flora. They also constitute an important and considerable social and clinical problem. The absence of inducing organic conditions or an infective focus at the base of the pathogenetic mechanism suggests the existence of alterations of the immune response of the subject.


METHODS
In this work we wanted to verify if, in those subjects with relapsing UTI (more than four events every year) cure with "biological" response modifiers, particularly "thymopentin", meaningfully reduced the number of events.


RESULTS
The results obtained confirm that for those cases in which the chemo-antibiotic therapy did not have the expected results, it is rational to support it with an immune-modulating drug (thymopentin). In fact the post-therapy reduction of UTI observed during two years of follow-up is statistically significant when compared to the average of UTI before therapy.


CONCLUSIONS
The "cost-benefits" analysis should prove to be a saving in favour of the use of thymopentin, taking into consideration the reduction of chemo-antibiotics consumption and the lower number of working hours lost every year.
Fontana
G
G
Ospedale SS. Annunziata, Savigliano, Cuneo, Azienda Sanitaria USL 17.
Ambruoso
G
G
Borsa
R
R
Savoia
D
D
Cavallo
G P
GP
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D016305:Thymopentin / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000503:physiopathology*
D000276:Adjuvants, Immunologic; D016305:Thymopentin