title: MRI-radiofrequency tissue tagging in patients with aortic insufficiency before and after operation.
abstract: BACKGROUND
  Magnetic resonance imaging tissue tagging is a relatively recent methodology that describes ventricular systolic function in terms of intramyocardial ventricular deformation. Because the analysis involves the use of many intramyocardial points to describe systolic deformation, it is theoretically more sensitive at describing subtle differences in regional myocardial fiber shortening when compared with conventional measures of ventricular function such as wall thickening. The objectives of this study were (1) to define sensitive indices of ventricular systolic deformation to assist the clinician in the surgical evaluation of patients with aortic insufficiency, and (2) to quantify differences in regional systolic deformation before and after surgery for aortic insufficiency.
  
  
  METHODS
  Magnetic resonance imaging with tissue tagging was performed on 10 normal volunteers and 8 patients with chronic severe aortic insufficiency. Follow-up postoperative studies (5.4+/-1.1 months) were obtained in 6 patients who underwent Ross procedure (1 patient), David procedure (1), and St. Jude aortic valve replacement (4).
  
  
  RESULTS
  There was no significant difference in fractional area change, overall circumferential shortening, or overall radial thickening among the normal group, the preoperative aortic insufficiency group, or the postoperative aortic insufficiency group. However, on a regional basis, there was a decrease in posterior wall circumferential strains in the postoperative aortic insufficiency group (29%+/-13% preoperative aortic insufficiency (n=6) versus 24%+/-12% postoperative aortic insufficiency (n=6), p=0.02).
  
  
  CONCLUSIONS
  On regional analysis, there was a small but significant decrease in posterior wall circumferential shortening after operation. Magnetic resonance imaging tissue tagging is a sensitive and clinically applicable method of quantifying regional ventricular wall function before and after intervention for aortic insufficiency.
authors.affiliation: Department of Surgery, Washington University, St. Louis, Missouri, USA.
authors.forename: F F
authors.initials: FF
authors.lastname: Ungacta
authors.forename: V G
authors.initials: VG
authors.lastname: Dávila-Román
authors.forename: M J
authors.initials: MJ
authors.lastname: Moulton
authors.forename: B P
authors.initials: BP
authors.lastname: Cupps
authors.forename: P
authors.initials: P
authors.lastname: Moustakidis
authors.forename: D S
authors.initials: DS
authors.lastname: Fishman
authors.forename: R
authors.initials: R
authors.lastname: Actis
authors.forename: B A
authors.initials: BA
authors.lastname: Szabo
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: N T
authors.initials: NT
authors.lastname: Kouchoukos
authors.forename: M K
authors.initials: MK
authors.lastname: Pasque
mesh_terms: D000328:Adult; D001022:Aortic Valve Insufficiency / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D003971:Diastole; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000502:physiology / Q000648:ultrastructure; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000473:pathology; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013599:Systole; D016277:Ventricular Function, Left / Q000502:physiology