Physicochemical characterizations of piroxicam-poloxamer solid dispersion.
To develop an efficient topical delivery system for piroxicam using poloxamer gel formulation, physicochemical behavior of piroxicam in poloxamer was studied. The gelling property of poloxamer and the solubility of piroxicam in the poloxamer were investigated. The interaction between piroxicam and poloxamer was studied by x-ray diffractometry (XRD), infrared (IR) spectroscopy and differential thermal analysis (DTA) with a solid dispersion, coprecipitate, or physical mixture. Poloxamer 407 solutions showed the property of a gel when the concentration was higher than 15% (w/w) and poloxamer 407 increased the aqueous solubility of piroxicam by about 11-fold at the concentration of 22.5% (w/w). The results of XRD did not show the crystalline from of piroxicam in the solid dispersion and results of IR spectroscopic analysis showed an association between functional groups of piroxicam and poloxamer.
Shin
S C
SC
College of Pharmacy, Chonnam National University, South Korea. shinsc@chonnam.chonnam.ac.kr
Cho
C W
CW
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004055:Differential Thermal Analysis; D016503:Drug Delivery Systems; D005782:Gels; D010894:Piroxicam / Q000737:chemistry*; D011060:Poloxalene / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D010894:Piroxicam; D011060:Poloxalene