Cancer predisposition: where's the phosphate?
Mutations in a protein phosphatase and a protein kinase cause hamartomatous polyposis syndromes, which are characterised by the formation of multiple benign polyps and an increased susceptibility to some types of cancer.
Smith
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Cancer Research Campaign Centre for Cell and Molecular Biology, Section of Gene Function and Regulation, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK. anna@icr.ac.uk
Ashworth
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D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D009154:Mutation; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D051059:PTEN Phosphohydrolase; D010710:Phosphates / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000235:genetics; D010744:Phosphoric Monoester Hydrolases; D011494:Protein Kinases / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins
D010710:Phosphates; D025521:Tumor Suppressor Proteins; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases; D010744:Phosphoric Monoester Hydrolases; D017027:Protein Tyrosine Phosphatases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human