Protein design: a perspective from simple tractable models
Recent progress in computational approaches to protein design builds on advances in statistical mechanical protein folding theory. Here, the number of sequences folding into a given conformation is evaluated and a simple condition for a protein model's designability is outlined.
Shakhnovich
EI
Harvard University Department of Chemistry and Chemical Biology 12 Oxford Street, Cambridge, MA 02138, USA eugene@belok.harvard.edu.