title: Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.
abstract: The goal of this review is to summarise the current knowledge concerning the targets of Ca++/calmodulin that are essential for cell cycle progression in lower eukaryotes. Emphasis is placed on Aspergillus nidulans since this is the only organism to date shown to posses essential Ca++ dependent calmodulin activated enzymes. Two such enzymes are the calmodulin activated protein phosphatase, calcineurin and the calmodulin dependent protein kinase. These proteins, each the product of a unique gene, are required for progression of quiescent spores into the proliferative cycle and also for execution of the nuclear division cycle in exponentially growing germlings.
authors.affiliation: Department of Pharmacology, Duke University Medical Center, Durham NC 27710, USA.
authors.forename: N N
authors.initials: NN
authors.lastname: Nanthakumar
authors.forename: J S
authors.initials: JS
authors.lastname: Dayton
authors.forename: A R
authors.initials: AR
authors.lastname: Means
mesh_terms: D001233:Aspergillus nidulans / Q000166:cytology* / Q000235:genetics / Q000378:metabolism*; D019703:Calcineurin / Q000235:genetics / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology*; D005800:Genes, Fungal; D008954:Models, Biological; D009154:Mutation
chemical_list: D002147:Calmodulin; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019703:Calcineurin; D002118:Calcium