title: Membrane fusion mediated by ricin and viscumin.
abstract: The ribosome inactivating plant proteins (RIPs) ricin and viscumin but not Ricinus communis agglutinin are able induce vesicle-vesicle fusion. A model is suggested in which the toxicity of the RIPs is partially determined by their fusogenicity. Herein, fusion is hypothesized to allow the RIPs to leak across endocytic vesicles to approve their access to cytoplasmic ribosomes.
authors.affiliation: Martin Luther Universität, Medizinische Fakultät, Institut für Medizinische Physik und Biophysik, 06097 Halle, Germany. peter.pohl@medizin.uni-halle.de
authors.forename: P
authors.initials: P
authors.lastname: Pohl
authors.forename: Y N
authors.initials: YN
authors.lastname: Antonenko
authors.forename: V Y
authors.initials: VY
authors.lastname: Evtodienko
authors.forename: E E
authors.initials: EE
authors.lastname: Pohl
authors.forename: S M
authors.initials: SM
authors.lastname: Saparov
authors.forename: I I
authors.initials: II
authors.lastname: Agapov
authors.forename: A G
authors.initials: AG
authors.lastname: Tonevitsky
mesh_terms: D002367:Ricinus communis / Q000737:chemistry; D005677:G(M1) Ganglioside / Q000494:pharmacology; D007476:Ionophores; D037102:Lectins / Q000494:pharmacology / Q000633:toxicity; D008051:Lipid Bilayers; D008081:Liposomes; D008561:Membrane Fusion / Q000187:drug effects*; D014784:Mistletoe / Q000737:chemistry; D009761:Nystatin; D037121:Plant Lectins; D028321:Plant Preparations; D010940:Plant Proteins; D010946:Plants, Medicinal; D010947:Plants, Toxic; D054790:Ribosome Inactivating Proteins, Type 2; D012276:Ricin / Q000494:pharmacology* / Q000633:toxicity; D014118:Toxins, Biological / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D007476:Ionophores; D037102:Lectins; D008051:Lipid Bilayers; D008081:Liposomes; D037121:Plant Lectins; D028321:Plant Preparations; D010940:Plant Proteins; D054790:Ribosome Inactivating Proteins, Type 2; C017707:Ricinus communis agglutinin-1; D014118:Toxins, Biological; C009674:ribosome inactivating protein, Viscum; D009761:Nystatin; D005677:G(M1) Ganglioside; D012276:Ricin