Studies on the behaviour of semicarbazide-sensitive amine oxidase in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine.
The possibility that increased levels of the activity of the semicarbazide-sensitive amine oxidase (SSAO) might, to some extent, compensate for the loss of monoamine oxidase (MAO) activity in the atypical form of Norrie Disease, was examined using the rat as a model. Long-term treatment with the MAO inhibitor tranylcypromine (1 mg/kg/day) resulted in sustained inhibition of MAO-A and MAO-B activities in liver and brain. After one week, the SSAO activity in heart had increased by 79% above the control levels. This increase was maintained for 3 weeks. Since such alterations might result from enzyme induction, the turnover of the enzyme was studied in cultured cells from rat aortic smooth muscle. The time-course of recovery of enzyme activity following irreversible inhibition by MDL 72145 corresponded to a half-life of approximately 6 days for this process.
Fitzgerald
D H
DH
Department of Biochemistry, Trinity College, Dublin, Ireland.
Tipton
K F
KF
Lyles
G A
GA
D000499:Allylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D006631:Amine Oxidase (Copper-Containing) / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000201:enzymology; D001921:Brain / Q000201:enzymology*; D002478:Cells, Cultured; D005260:Female; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008099:Liver / Q000201:enzymology*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014191:Tranylcypromine / Q000494:pharmacology*
D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D014191:Tranylcypromine; D000499:Allylamine; C040051:2-(3,4-dimethoxyphenyl)-3-fluoroallylamine; D006631:Amine Oxidase (Copper-Containing); D008995:Monoamine Oxidase