[Immunology in clinical practice. XI. IgG receptors: the role of polymorphism in autoimmune and infectious diseases].
Receptors for the constant part of IgG (Fc gamma R) are implicated in the pathogenesis of a number of diseases. Children from mothers with an Fc gamma RIIIb deficiency may suffer from neonatal neutropenia due to an alloimmune reaction. Interindividual differences (polymorphisms) for a number of Fc gamma R represent risk factors for several infectious and autoimmune diseases. Immunotherapeutic use of several monoclonal antibody subclasses is affected by Fc gamma R polymorphisms. Fc gamma R can be used for cellular entrance by lymphotropic viruses (such as HIV) and appear to be involved in the pathogenesis of fulminant Dengue virus infections.
van der Pol
W L
WL
Academisch Ziekenhuis, Afd. Immunologie, Utrecht.
Kuijper
E J
EJ
Koene
H R
HR
de Haas
M
M
Sanders
E A
EA
van de Winkel
J G
JG
D000818:Animals; D019067:Antibody-Dependent Enhancement; D015703:Antigens, CD / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007239:Infections / Q000276:immunology*; D051379:Mice; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology*; D012307:Risk Factors; D014181:Transplantation Immunology
D015703:Antigens, CD; D017452:Receptors, IgG