The functions of Myc in cell cycle progression and apoptosis.
c-myc has emerged as one of the central regulators of mammalian cell proliferation. The gene encodes a transcription factor of the HLH/leucine zipper family of proteins that activates transcription as part of a heteromeric complex with a protein termed Max. In mammalian fibroblasts, Myc acts as an upstream regulator of cyclin-dependent kinases and functionally antagonises the action of at least one cdk inhibitor, p27. Myc also induces cells to undergo apoptosis, and the relationship between Myc-induced cell cycle entry and apoptosis is discussed.
Steiner
P
P
Zentrum für Molekulare Biologie Heidelberg (ZMBH).
Rudolph
B
B
Müller
D
D
Eilers
M
M
D000818:Animals; D017209:Apoptosis / Q000235:genetics* / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics* / Q000502:physiology; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D004789:Enzyme Activation; D016259:Genes, myc; D006801:Humans; D008954:Models, Biological; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology
D016213:Cyclins; D016271:Proto-Oncogene Proteins c-myc; D018844:Cyclin-Dependent Kinases