title: Health-related quality of life assessment in euthymic and depressed patients with bipolar disorder. Psychometric performance of four self-report measures.
abstract: The purpose of this study was to evaluate the psychometric properties of selected health-related quality of life (HRQL) self-report measures in 62 euthymic and depressed patients diagnosed with bipolar disorder. Patients completed the Quality of Life in Depression Scale (QLDS), Mental Health Index-17 (MHI-17), Cognitive Function Scale, and Medical Outcomes Study Short Form-36 (SF-36) at baseline and 8 weeks following treatment. Hamilton and Young Rating Scales were used to assess clinical status and validate the HRQL measures. The MHI-17, Cognitive Function Scale, QLDS, and SF-36 social function, vitality, role limitations-emotional, and mental health scales have good reliability and validity, and are responsive to changes in clinical status in patients with bipolar disorder. Although the small sample size limits generalizablity, euthymic and depressed outpatients with bipolar disorder appear to contribute reliable self reports on selected aspects of their quality of life.
authors.affiliation: MEDTAP International, Bethesda, MD 20814, USA.
authors.forename: N K
authors.initials: NK
authors.lastname: Leidy
authors.forename: C
authors.initials: C
authors.lastname: Palmer
authors.forename: M
authors.initials: M
authors.lastname: Murray
authors.forename: J
authors.initials: J
authors.lastname: Robb
authors.forename: D A
authors.initials: DA
authors.lastname: Revicki
mesh_terms: D000328:Adult; D000342:Affective Symptoms / Q000188:drug therapy / Q000523:psychology*; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000188:drug therapy / Q000523:psychology*; D016009:Chi-Square Distribution; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics / Q000592:standards*; D011788:Quality of Life; D015203:Reproducibility of Results; D016896:Treatment Outcome