title: Laryngeal radionecrosis versus recurrent cancer: a clinical approach.
abstract: A group of 38 patients was studied by positron emission tomography utilizing fluorine18-labeled deoxyglucose (FDG-PET) scanning to examine the ability to differentiate postirradiation laryngeal recurrent cancer from radionecrosis. The resulting 79% correct diagnosis showed the technique to be far superior to conventional computed tomography scanning (61%) and clinical examination (43%). An algorithmic approach to evaluating and treating patients with radionecrosis and/or recurrent cancer by utilizing FDG-PET scanning is presented.
authors.affiliation: Department of Otolaryngology, Wake Forest University Medical Center, Winston-Salem, North Carolina 27157-1034, USA.
authors.forename: W F
authors.initials: WF
authors.lastname: McGuirt
authors.forename: K M
authors.initials: KM
authors.lastname: Greven
authors.forename: J W
authors.initials: JW
authors.lastname: Keyes
authors.forename: D W
authors.initials: DW
authors.lastname: Williams
authors.forename: N
authors.initials: N
authors.lastname: Watson
mesh_terms: D000465:Algorithms; D003937:Diagnosis, Differential; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D009336:Necrosis; D009364:Neoplasm Recurrence, Local; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging*; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D011832:Radiation Injuries / Q000000981:diagnostic imaging*; D011878:Radiotherapy / Q000009:adverse effects*; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18