Comparison of simultaneous patch testing with parthenolide and sesquiterpene lactone mix.
Several studies have pointed out that the sesquiterpene lactone (SL) mix is a safe, though inadequate, screen for Compositae allergy. To test the usefulness of the sesquiterpene lactone parthenolide as a supplementary Compositae screening test to the mix, both were included in the standard series in 2 Danish dermatology departments. Among 2244 patients tested, 46 (2%) were positive to SL mix and 73-75% of these were positive to parthenolide. The results demonstrate that parthenolide is not suitable as a supplementary screening agent to SL mix, but may be a fairly good screen on its own if the mix is not available.
Orion
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Department of Dermatology, Tel-Aviv Medical Center, Israel.
Paulsen
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Andersen
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KE
Menné
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T
D019659:Asteraceae / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D006801:Humans; D010328:Patch Tests / Q000379:methods*; D010946:Plants, Medicinal / Q000009:adverse effects*; D012717:Sesquiterpenes / Q000009:adverse effects*
D012717:Sesquiterpenes; C002669:parthenolide