Transforming the cell surface through proteolysis.
Protein shedding, or the proteolytic cleavage of a protein from the surface of a cell, is emerging as an important mechanism in the regulation of cellular activity but it is poorly understood. Growing evidence suggesting that protein shedding and protein function are closely linked may lead to new strategies for the treatment of a wide range of diseases.
Kiessling
L L
LL
Department of Chemistry, University of Wisconsin-Madison 53706, USA. kiessling@chem.wisc.edu
Gordon
E J
EJ
D000906:Antibodies / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism*; D006868:Hydrolysis; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism
D000906:Antibodies; D008024:Ligands; D008565:Membrane Proteins; D011956:Receptors, Cell Surface