Duplication of the pituitary gland in a newborn with median cleft face syndrome and nasal teratoma.
A newborn suffered immediate neonatal respiratory distress because of an obstructive, soft-tissue nasal mass. Clinical examination revealed a cleft palate with a protruding polypoid mass. CT and MRI showed a heterogeneous nasopharyngeal mass and associated intracranial abnormalities - duplication of the hypophysis and hypoplasia of the corpus callosum. Duplication of the hypophysis is a very rare malformation, only 13 cases having been previously described. The suggested pathogenesis is duplication of the prechordal plate and anterior end of the notochord during early embryological development.
Hamon-Kérautret
M
M
Service de Neuroradiologie, Hôpital Roger Salengro, CHRU Lille, France.
Ares
G S
GS
Demondion
X
X
Rouland
V
V
Francke
J P
JP
Pruvo
J P
JP
D002972:Cleft Palate / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000150:complications*; D010902:Pituitary Gland / Q000002:abnormalities*; D013577:Syndrome; D013724:Teratoma / Q000150:complications*; D014057:Tomography, X-Ray Computed