Mapping of the human P84 gene to the subtelomeric region of chromosome 20p.
P84 is a novel neural adhesion molecule that may play an important role in synaptogenesis. We have recently cloned a murine cDNA encoding the P84 adhesion molecule. The human homologue of P84 has previously been isolated (by others) as a brain specific cDNA containing CCA repeats. We have mapped the human P84 gene to the subtelomeric region of chromosome 20p (20p13) by FISH. In addition, we have been able to place P84 onto the high resolution physical map of the human genome by utilizing the Unigene database. P84 maps to several YAC clones, between STS markers IB255 and WI-9632, and very close to the polymorphic marker D20S199, in an interval of less than 1 Mb on 20p13. P84 is a strong candidate gene for neurological disorders which map into this region.
Eckert
C
C
Children's Hospital of Pittsburgh, Pennsylvania, USA.
Olinsky
S
S
Cummins
J
J
Stephan
D
D
Narayanan
V
V
D000818:Animals; D000943:Antigens, Differentiation; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D017931:DNA Primers; D016208:Databases, Factual; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules / Q000235:genetics*; D011971:Receptors, Immunologic; D016615:Telomere; D018911:Trinucleotide Repeats
D000943:Antigens, Differentiation; D017931:DNA Primers; D008562:Membrane Glycoproteins; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules; D011971:Receptors, Immunologic