title: Inhibition of ornithine decarboxylase by ifenprodil.
abstract: Ifenprodil (NMDA receptor antagonist) was tested as an inhibitor of ornithine decarboxylase. It was found that ifenprodil inhibited ornithine decarboxylase activity with the same potency as alpha-difluoromethylornithine, a major inhibitor of ornithine decarboxylase. This result suggests that ifenprodil could target either the polyamine site on the NMDA receptor complex or/and polyamine biosynthesis.
authors.affiliation: Laboratory of Bioanalytical Chemistry, Toxicology and Applied Physical Chemistry, Institute de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Badolo
authors.forename: J
authors.initials: J
authors.lastname: Dubois
authors.forename: M
authors.initials: M
authors.lastname: Helson-Cambier
authors.forename: M
authors.initials: M
authors.lastname: Hanocq
mesh_terms: D015317:Biogenic Polyamines / Q000378:metabolism; D000518:Eflornithine / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D065108:Ornithine Decarboxylase Inhibitors; D010880:Piperidines / Q000494:pharmacology*; D011700:Putrescine / Q000031:analogs & derivatives / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
chemical_list: D015317:Biogenic Polyamines; D004791:Enzyme Inhibitors; D018691:Excitatory Amino Acid Antagonists; C112324:N(1),N(4)-bis(benzyl)-N(1),N(4)-bis(methyl)putrescine; D065108:Ornithine Decarboxylase Inhibitors; D010880:Piperidines; D016194:Receptors, N-Methyl-D-Aspartate; C010739:ifenprodil; D011700:Putrescine; D000518:Eflornithine