title: Increased overall antibiotic susceptibility in Staphylococcus aureus femAB null mutants.
abstract: The staphylococcal pentaglycine side chain of the peptidoglycan is reduced to one glycine in femAB null mutants. This is associated with increased susceptibility to methicillin and to a whole range of unrelated antibiotics as well. Genetic evidence suggests that femAB null mutants are only viable because of a compensatory mutation in an unlinked site.
authors.affiliation: Institute of Medical Microbiology, University of Zürich, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Ling
authors.forename: B
authors.initials: B
authors.lastname: Berger-Bächi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005798:Genes, Bacterial / Q000235:genetics*; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D010457:Peptidoglycan / Q000235:genetics / Q000378:metabolism; D015183:Restriction Mapping; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D010457:Peptidoglycan