[Corticosteroid sensitivity, dependence and resistance in inflammatory and immunologic diseases. Physiopathologic review].
Patients suffering from inflammatory or dysimmunitary diseases may develop various clinical responses to corticotherapy. This brief article describes the various cellular and molecular mechanisms which underly the genetic, endocrine and immunitary factors involved in corticosensitivity, corticoresistance and corticodependence.
Franchimont
D
D
Service de Gastroentérologie, Université de Liège.
Belaiche
J
J
Geenen
V
V
D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology*; D004342:Drug Hypersensitivity / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D004351:Drug Resistance / Q000235:genetics / Q000276:immunology / Q000502:physiology; D004361:Drug Tolerance / Q000235:genetics / Q000276:immunology / Q000502:physiology; D005938:Glucocorticoids / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology; D007154:Immune System Diseases / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy; D008967:Molecular Biology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology; D011965:Receptors, Glucocorticoid / Q000187:drug effects; D014157:Transcription Factors / Q000037:antagonists & inhibitors
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011965:Receptors, Glucocorticoid; D014157:Transcription Factors