[Key role of plasma membrane receptor domains in carcinogenesis].
Within the limits of the previously proposed conception concerning the dynamical domain organization of receptor molecules in biological membranes the possible role of receptor domains (RD) of plasma membranes in the mechanism of carcinogenesis is discussed. On the basis of extensive experimental material accumulating to present by study of different aspects of carcinogenesis, and based on the key role of receptor domains of plasma membranes in this process the attempt has been made to build the general theory of carcinogenesis. Particular attention is given to the analysis of possible genetically depended changes in the system of cell division and cell differentiation control, which may be responsible for the appearance of non-malignant and malignant tumours in the organism, and also to the consideration of the conditions of the appearance of clones of transformed cells with uncontrolled growth in the organism. Differences in the molecular mechanisms of the appearance of non-malignant and malignant tumours are explained.
Talako
S A
SA
Laboratory of Molecular Bases Reception, Belarus.
D002471:Cell Transformation, Neoplastic; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000502:physiology*
D011956:Receptors, Cell Surface