Neurodevelopmental and neuroprogressive processes in schizophrenia. Antithetical or complementary, over a lifetime trajectory of disease?
The neurodevelopmental model of schizophrenia maintains ascendancy among current etiopathologic perspectives on schizophrenia. However, inconsistencies across studies and the absence thus far of pathognomic brain changes suggest the need for complex conceptualization of neurodevelopmental arrest, including some reconciliation with the competing neurodegenerative model of schizophrenia. This article critically reviews the preponderance of evidence for each model and provides an account of how these may interact or synergize to produce the characteristic clinical expression of schizophrenia.
Waddington
J L
JL
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland.
Lane
A
A
Scully
P J
PJ
Larkin
C
C
O'Callaghan
E
E
D017668:Age of Onset; D001526:Behavioral Symptoms; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000503:physiopathology; D019465:Craniofacial Abnormalities / Q000196:embryology / Q000235:genetics; D018450:Disease Progression; D006801:Humans; D008959:Models, Neurological; D009410:Nerve Degeneration / Q000503:physiopathology; D019954:Neurobehavioral Manifestations; D012559:Schizophrenia / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors