title: Effects of Bayluscide WP 70 on the survival and water-leaving behaviour of Biomphalaria straminea, snail host of schistosomiasis in northeast Brazil.
abstract: The toxic and behavioural effects of niclosamide (Bayluscide WP 70) on Biomphalaria straminea from a highly endemic area of schistosomiasis in northeastern Brazil were investigated through laboratory bioassays. The LD50 and LD90 were 0.114 mg/l and 0.212 mg/l, respectively. Water-leaving behaviour occurred among 14% to 30% of the snails in the presence of sublethal doses of niclosamide and among 16% of the controls. It was concluded that both the relatively low susceptibility to niclosamide and water-leaving behaviour of local B. straminea may be responsible for the recolonization of transmission foci after mollusciciding. It was suggested that recently improved measures of snail control, such as controlled-release formulations of niclosamide and plant molluscicides should be considered in areas where snail control is recommended.
authors.affiliation: Departamento de Biologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
authors.forename: O
authors.initials: O
authors.lastname: Sarquis
authors.forename: O S
authors.initials: OS
authors.lastname: Pieri
authors.forename: J A
authors.initials: JA
authors.lastname: dos Santos
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000187:drug effects* / Q000469:parasitology / Q000502:physiology*; D001938:Brazil / Q000453:epidemiology; D008975:Molluscacides / Q000494:pharmacology*; D009534:Niclosamide / Q000494:pharmacology*; D012552:Schistosomiasis / Q000453:epidemiology
chemical_list: D008975:Molluscacides; D009534:Niclosamide