Cryptococcosis: an unusual opportunistic infection complicating B cell lymphoproliferative disorders.
We report two cases of cryptococcosis in patients with Waldenstrom's macroglobulinaemia and chronic lymphocytic leukaemia that responded to prolonged therapy with systemic amphotericin and flucytosine. Cryptococcosis, although more common in those with impaired cell mediated immunity, should also be considered as a complication in patients with impaired antibody responses.
Melzer
M
M
Department of Infection and Tropical Medicine, University of Newcastle Medical School, Newcastle General Hospital, Newcastle upon Tyne, UK.
Colbridge
M
M
Keenan
F
F
Stainsby
D
D
Ong
E L
EL
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003453:Cryptococcosis / Q000150:complications* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy; D008258:Waldenstrom Macroglobulinemia / Q000150:complications*
D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine