title: PCPP as a parenteral adjuvant for diverse antigens.
abstract: The adjuvanticity of the phosphazene polymer, poly[di(carboxylatophenoxy) phosphazene] (PCPP) was examined with a diverse collection of immunogens. PCPP proved to be a potent adjuvant for trivalent influenza virus vaccine, tetanus toxoid, hepatitis B surface antigen, herpes simplex virus glycoprotein gD2 and the capsular polysaccharide, polyribosylribitolphosphate, from Haemophilus influenzae type b. Taken together these results clearly demonstrate the general utility of PCPP as an adjuvant. Furthermore, PCPP was a superior adjuvant at least with TT compared to similar negatively charged polyanions, polymethylacrylic acid and polyacrylic acid.
authors.affiliation: Virus Research Institute, Inc., Cambridge, MA, USA.
authors.forename: L G
authors.initials: LG
authors.lastname: Payne
authors.forename: G
authors.initials: G
authors.lastname: Van Nest
authors.forename: G L
authors.initials: GL
authors.lastname: Barchfeld
authors.forename: G R
authors.initials: GR
authors.lastname: Siber
authors.forename: R K
authors.initials: RK
authors.lastname: Gupta
authors.forename: S A
authors.initials: SA
authors.lastname: Jenkins
mesh_terms: D000179:Acrylates; D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D001672:Biocompatible Materials; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011108:Polymers; D018139:Simplexvirus / Q000276:immunology; D018074:Vaccines, Conjugate / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology
chemical_list: D000179:Acrylates; D000276:Adjuvants, Immunologic; D001672:Biocompatible Materials; D018073:Haemophilus Vaccines; D006514:Hepatitis B Surface Antigens; D011108:Polymers; D018074:Vaccines, Conjugate; D014759:Viral Envelope Proteins; C040570:glycoprotein D-herpes simplex virus type 2; C045869:polybis(carbophenoxypropane)