title: [Nerve circuit disorders: determination of polyneuropathy].
abstract: So many conditions, both hereditary and acquired, can lead to polyneuropathy that a systematic approach is needed to identify the cause. Finding a cause is necessary to inform the patient about prognosis, handicap and chances of treatment. Three patients with polyneuropathy are described. The first was a man aged 34 with a predominantly motor neuropathy who appeared to have a duplication in the pmp-22 gene on chromosome 17PII.2. The diagnosis was hereditary sensorimotor neuropathy type IA (hypertrophic form of Charcot-Marie-Tooth disease). The second was a woman of 58 years; she had a sensory polyneuropathy as the first manifestation of Hodgkin's disease. The last patient, a 67-year-old man, had polyneuropathy due to vasculitis. He showed a prompt response to treatment.
authors.affiliation: Academisch Ziekenhuis, afd. Neurologie, Utrecht.
authors.forename: J H
authors.initials: JH
authors.lastname: Wokke
authors.forename: N C
authors.initials: NC
authors.lastname: Notermans
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D015417:Hereditary Sensory and Motor Neuropathy / Q000175:diagnosis / Q000503:physiopathology*; D006689:Hodgkin Disease / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000503:physiopathology*; D011115:Polyneuropathies / Q000503:physiopathology; D012678:Sensation Disorders / Q000503:physiopathology; D014657:Vasculitis / Q000175:diagnosis / Q000503:physiopathology*