title: In vitro interaction between ofloxacin and cefotaxime against gram-positive and gram-negative bacteria involved in serious infections.
abstract: The checkerboard method was used to determine the antimicrobial activity of the combination cefotaxime/ofloxacin against 217 bacterial isolates involved in serious infections. Synergy or partial synergy was observed against 19 of 34 (55.8%) Staphylococcus aureus methicillin-susceptible isolates, 4 of 47 (8.4%) Streptococcus pneumoniae isolates, 28 of 34 (82.2%) Escherichia coli isolates and 70 of 102 (68.5%) Pseudomonas aeruginosa isolates. Antagonism was not observed with any of the isolates examined.
authors.affiliation: Department of Microbiology, University Hospital and Medical School, Valencia, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Gimeno
authors.forename: J
authors.initials: J
authors.lastname: Borja
authors.forename: D
authors.initials: D
authors.lastname: Navarro
authors.forename: L
authors.initials: L
authors.lastname: Valdés
authors.forename: J
authors.initials: J
authors.lastname: García-Barbal
authors.forename: J
authors.initials: J
authors.lastname: García-de-Lomas
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001424:Bacterial Infections / Q000382:microbiology*; D002439:Cefotaxime / Q000008:administration & dosage / Q000494:pharmacology*; D018550:Cephalosporin Resistance; D002511:Cephalosporins / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000008:administration & dosage / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D000890:Anti-Infective Agents; D002511:Cephalosporins; D015242:Ofloxacin; D002439:Cefotaxime