[Recent development of nucleic acid drug].
Oligonucleotides and their analogs have been utilized for the regulation of gene expression since mid-1970. The so-called antisense strategy has recently acquired its reality of the application to clinical therapeutic uses. In the course of the development, it has been found that nucleic acids might have broad variety of abilities to regulate gene expression. The abilities are classified as ribozymes, antigenes, decoy DNAs (or RNAs) and aptamers, and they can be applied to clinical uses as nucleic acid drugs in the near future.
Murakami
A
A
Kyoto Institute of Technology, Department of Polymer Science and Engineering.
Yamaoka
T
T
Iwase
R
R
D000941:Antigens; D016375:Antisense Elements (Genetics); D016503:Drug Delivery Systems; D015195:Drug Design; D015870:Gene Expression; D005818:Genetic Engineering; D009696:Nucleic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D012313:RNA; D016337:RNA, Catalytic
D000941:Antigens; D016375:Antisense Elements (Genetics); D009696:Nucleic Acids; D016337:RNA, Catalytic; D012313:RNA