title: Is topical tretinoin safe during the first trimester?
abstract: QUESTIONOne of my patients conceived while using a topical tretinoin preparation for acne. I know this drug is related to Accutane, which is teratogenic. How should I advise her?ANSWERAvailable evidence suggests that topical tretinoin does not increase teratogenic risk in humans.
authors.affiliation: Hospital for Sick Children, Toronto.
authors.forename: L
authors.initials: L
authors.lastname: Shapiro
authors.forename: A
authors.initials: A
authors.lastname: Pastuszak
authors.forename: G
authors.initials: G
authors.lastname: Curto
authors.forename: G
authors.initials: G
authors.lastname: Koren
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000152:Acne Vulgaris / Q000188:drug therapy*; D000279:Administration, Cutaneous; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D014212:Tretinoin / Q000009:adverse effects*
chemical_list: D007641:Keratolytic Agents; D014212:Tretinoin