Protective role of superoxide dismutase in iron toxicity in yeast.
It has been found that yeast mutants deficient in cytosolic superoxide dismutase CuZnSOD are hypersensitive to ferrous iron. In contrast mutants that are deficient in catalases and cytochrome c peroxidase do not differ from the standard strain in this respect. These findings suggest that iron toxicity may depend on the redox status of the cell. They also shed light on the role of superoxide dismutases in preventing the toxic effects of oxygen.
Wiśnicka
R
R
Zamość College of Agriculture, Agricultural University of Lublin, Zamość ul. Szczebrzeska, Poland.
Krzepiłko
A
A
Wawryn
J
J
Krawiec
Z
Z
Biliński
T
T
D020642:Acatalasia; D002455:Cell Division / Q000187:drug effects / Q000235:genetics; D003578:Cytochrome-c Peroxidase / Q000172:deficiency; D006861:Hydrogen Peroxide / Q000378:metabolism; D007501:Iron / Q000493:pharmacokinetics / Q000633:toxicity*; D009154:Mutation; D010100:Oxygen / Q000633:toxicity; D013482:Superoxide Dismutase / Q000502:physiology*; D015003:Yeasts / Q000502:physiology*
D006861:Hydrogen Peroxide; D007501:Iron; D003578:Cytochrome-c Peroxidase; D013482:Superoxide Dismutase; D010100:Oxygen