Acute hepatic failure in a child treated with lamotrigine.
An 8-year-old boy with a known seizure disorder that was being treated with lamotrigine developed acute hepatic failure. The patient, who had been well previously, presented with jaundice, elevated liver enzymes, and a coagulopathy. After discontinuation of lamotrigine and aggressive resuscitation, the patient made an uneventful recovery. We believe that the hepatic failure in our patient was secondary to the use of lamotrigine. We recommend careful monitoring of liver function when lamotrigine is administered.
Arnon
R
R
Department of Pediatrics, Columbia University School of Medicine, New York, New York 10032, USA.
DeVivo
D
D
Defelice
A R
AR
Kazlow
P G
PG
D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D000077213:Lamotrigine; D017114:Liver Failure, Acute / Q000188:drug therapy*; D008297:Male; D014227:Triazines / Q000627:therapeutic use*
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine