title: [Intrathecal interferon therapy in chronic echovirus meningoencephalitis in Bruton type agammaglobulinemia].
abstract: A 9-year-old body with X-linked agammaglobulinemia developed chronic enteroviral meningoencephalitis (CEMA) caused by echovirus type 6. Intravenous treatment with selected immunoglobulin charges containing high titers against echovirus type 6 or combination with beta-interferon did not result in improvement. After implantation of a Rickham reservoir and periodical administration of intraventricular and intravenous immunoglobulin the virus recurred rapidly each time treatment was stopped. After 20 months of treatment the patient received a combined therapy with beta-interferon and selected immunoglobulin. Both drugs were given by lumbar puncture, intravenously and via Rickham reservoir. Subsequently echovirus type 6 could not be isolated in culture or PCR. Cerebrospinal fluid pleocytosis disappeared. The remission is lasting for more than three years. Intrathecal and intraventricular beta-interferon therapy for CEMA is being reported for the first time. Facing the unfavourable prognosis of the disease this mode of treatment is a new therapeutic approach following failure of other therapies.
authors.affiliation: Kinderklinik der Städtischen Kliniken Kassel.
authors.forename: A
authors.initials: A
authors.lastname: von der Wense
authors.forename: B
authors.initials: B
authors.lastname: Herrmann
authors.forename: R
authors.initials: R
authors.lastname: Deppermann
authors.forename: F
authors.initials: F
authors.lastname: Harms
authors.forename: H
authors.initials: H
authors.lastname: Wehinger
mesh_terms: D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004458:Echovirus 6, Human / Q000276:immunology; D004457:Echovirus Infections / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007116:Immunization, Passive / Q000295:instrumentation; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal; D016899:Interferon-beta / Q000008:administration & dosage*; D008297:Male; D008590:Meningoencephalitis / Q000276:immunology / Q000628:therapy*; D012729:Sex Chromosome Aberrations / Q000235:genetics; D014960:X Chromosome
chemical_list: D000914:Antibodies, Viral; D016899:Interferon-beta