title: Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D2.
abstract: This study was undertaken to evaluate the role of brain PGD2 activity during PTZ induced seizures in rats. Potentiation of endogenous PGD2 activity caused an anti-convulsant effect. Thus, after PGD2 injection (5 microg/icv) the latency of generalized tonic clonic convulsions was prolonged. ZK 118.182, a stable analogue of PGD2, dose-dependently inhibited the incidence and the intensity of seizures when injected at doses of 1-100 ng/icv. But on the other hand, inhibition of PGD2 activity either by a D-type PG receptor antagonist (AH 6809; 50 ng/icv) or by a PGD synthase inhibitor (sodium selenite; 0.2 microg/icv) produced a proconvulsant effect by increasing the incidence and the intensity of the seizures. These findings indicate that endogenous PGD2 activity in the brain may have a specific inhibitory role for the initiation and propagation of PTZ induced seizures in rats.
authors.affiliation: Department of Pharmacology & Clinical Pharmacology, Faculty of Medicine, University of Ankara, Turkey. akarsu@dialup.ankara.edu.tr
authors.forename: E S
authors.initials: ES
authors.lastname: Akarsu
authors.forename: S
authors.initials: S
authors.lastname: Mamuk
authors.forename: A
authors.initials: A
authors.lastname: Comert
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D002552:Cerebral Ventricles / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D015237:Dinoprost / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004830:Epilepsy, Tonic-Clonic / Q000503:physiopathology* / Q000517:prevention & control; D007276:Injections, Intraventricular; D008297:Male; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D011448:Prostaglandin Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D015230:Prostaglandin D2 / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D018038:Sodium Selenite / Q000008:administration & dosage / Q000494:pharmacology; D014966:Xanthenes / Q000008:administration & dosage / Q000494:pharmacology; D044004:Xanthones
chemical_list: D000927:Anticonvulsants; D011448:Prostaglandin Antagonists; D014966:Xanthenes; D044004:Xanthones; C067426:ZK 118182; C053876:6-isopropoxy-9-oxoxanthene-2-carboxylic acid; D015237:Dinoprost; D018038:Sodium Selenite; D015230:Prostaglandin D2; D010433:Pentylenetetrazole