title: A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia.
abstract: We investigated blood-brain barrier (BBB) function in relation to Alzheimer's disease (AD) and vascular dementia (VAD) in the very elderly. Sixty-five 85-year-old persons from a population-based sample were followed for 3 years; 29 were demented at age 85 (13 with AD, 14 with VAD, and 2 with other dementias), 7 developed dementia during follow-up, and 29 remained nondemented. CSF/serum albumin ratio was used as as a measure of BBB function. Dementia was defined according to the DSM-III-R, AD according to the NINCDS-ADRDA criteria, and VAD according to the NINDS-Association Internationale pour la Recherche et l'Enseignement en Neurosciences (AIREN) criteria. Mean CSF/serum albumin ratio was higher in all dementias (8.5 +/- 4.3; p = 0.007) and in the subtypes AD (8.9 +/- 5.3; p = 0.046) and VAD (8.7 +/- 3.5; p = 0.002) than in nondemented individuals (versus 6.5 +/- 2.0), but it was not related to dementia severity. Nondemented women at age 85 (n = 3) who developed dementia during the follow-up had a higher CSF/serum albumin ratio than those not developing dementia (10.4 +/- 2.0 versus 6.0 +/- 1.9; p = 0.007). Nondemented individuals lacking the apolipoprotein E epsilon3 allele (n = 4) had a higher CSF/serum albumin ratio (9.3 +/- 0.8 versus 6.6 +/- 2.1; p = 0.029) than other individuals. A relative BBB dysfunction is associated with both AD and VAD among very elderly individuals. This finding is possibly found early in the disease before the onset of clinical dementia.
authors.affiliation: Department of Psychiatry, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Skoog
authors.forename: A
authors.initials: A
authors.lastname: Wallin
authors.forename: P
authors.initials: P
authors.lastname: Fredman
authors.forename: C
authors.initials: C
authors.lastname: Hesse
authors.forename: O
authors.initials: O
authors.lastname: Aevarsson
authors.forename: I
authors.initials: I
authors.lastname: Karlsson
authors.forename: C G
authors.initials: CG
authors.lastname: Gottfries
authors.forename: K
authors.initials: K
authors.lastname: Blennow
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000418:Albumins / Q000134:cerebrospinal fluid; D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D053318:Apolipoprotein E3; D001057:Apolipoproteins E / Q000235:genetics; D001812:Blood-Brain Barrier / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D015140:Dementia, Vascular / Q000097:blood / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D005260:Female; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D000418:Albumins; D053318:Apolipoprotein E3; D001057:Apolipoproteins E; D012709:Serum Albumin