title: Comparison of final heights of growth hormone-treated vs. untreated children with idiopathic growth failure.
abstract: We measured adult heights (Ht) of 94 healthy GH-sufficient children (peak GH > 10 ng/mL, polyclonal RIA) whose Ht at presentation were more than 2 SD below the mean for chronological age, with normal weight-to-Ht ratios, normal body proportions, and pathologic growth velocity for chronological age. Group 1 (n 36, 6 females) received standardized doses (0.3 mg/kg x week) of GH (mean duration = 41 months), while group 2 (n = 58, 17 females) received no treatment. Our conclusion was that the mean final Ht SD score in the GH-treated group (-1.5) was significantly greater than in the untreated group (-2.1); P < .001. Genetic predisposition to short stature was evident in both groups: the midparental Ht SD score was -1.1 in the treated and -1.0 in the untreated group. Midparental Ht was met or exceeded by 42% of the GH-treated group but only 15% of the untreated group. Final Ht was not significantly different from predicted Ht, except from GH-treated girls, who exceeded their predicted Ht. Although the mean Ht gains (6.8 cm in girls and 3 cm in boys) were modest and variable, GH treatment provided significantly better Ht outcomes for the majority of children with idiopathic growth failure.
authors.affiliation: Department of Pediatrics, University at Buffalo School of Medicine and Children's Hospital of Buffalo, New York 14222, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Buchlis
authors.forename: L
authors.initials: L
authors.lastname: Irizarry
authors.forename: B C
authors.initials: BC
authors.lastname: Crotzer
authors.forename: B J
authors.initials: BJ
authors.lastname: Shine
authors.forename: L
authors.initials: L
authors.lastname: Allen
authors.forename: M H
authors.initials: MH
authors.lastname: MacGillivray
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011379:Prognosis
chemical_list: D019382:Human Growth Hormone