title: Diastereomeric separation of 1,5-benzodiazepines due to the presence of a chiral centre on the N-5 alkylic chain.
abstract: The presence of a chain bearing a stereogenic centre at the N-5 position of 1-(1-adamantylmethyl)-3-arylureido-2,4-dioxo-1,5-benzodiazep ines induces optical resolution. The synthesis of these compounds and their potency as potential CCK-B receptor antagonists is discussed briefly here.
authors.affiliation: Glaxo Wellcome S.p.A., Medicines Research Centre, Verona, Italy.
authors.forename: G L
authors.initials: GL
authors.lastname: Araldi
authors.forename: D
authors.initials: D
authors.lastname: Donati
authors.forename: M E
authors.initials: ME
authors.lastname: Tranquillini
authors.forename: A
authors.initials: A
authors.lastname: Ursini
mesh_terms: D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; D001569:Benzodiazepines