title: Safety and cost-effectiveness of early discharge after primary angioplasty in low risk patients with acute myocardial infarction. PAMI-II Investigators. Primary Angioplasty in Myocardial Infarction.
abstract: OBJECTIVE
  The second Primary Angioplasty in Myocardial Infarction (PAMI-II) study evaluated the hypothesis that primary percutaneous transluminal coronary angioplasty (PTCA), with subsequent discharge from the hospital 3 days later, is safe and cost-effective in low risk patients.
  
  
  BACKGROUND
  In low risk patients with myocardial infarction (MI), few data exist regarding the need for intensive care and noninvasive testing or the appropriate length of hospital stay.
  
  
  METHODS
  Patients with acute MI underwent emergency catheterization with primary PTCA when appropriate. Low risk patients (age <70 years, left ventricular ejection fraction >45%, one- or two-vessel disease, successful PTCA, no persistent arrhythmias) were randomized to receive accelerated care (admission to a nonintensive care unit and day 3 hospital discharge without noninvasive testing [n = 237] or traditional care [n = 234]).
  
  
  RESULTS
  Patients who received accelerated care had similar in-hospital outcomes but were discharged 3 days earlier (4.2+/-2.3 vs. 7.1+/-4.7 days, p = 0.0001) and had lower hospital costs ($9,658+/-5,287 vs. $11,604+/-6,125 p = 0.002) than the patients who received traditional care. At 6 months, accelerated and traditional care groups had a similar rate of mortality (0.8% vs. 0.4%, p = 1.00), unstable ischemia (10.1% vs. 12.0%, p = 0.52), reinfarction (0.8% vs. 0.4%, p = 1.00), stroke (0.4% vs. 2.6%, p = 0.07), congestive heart failure (4.6% vs. 4.3%, p = 0.85) or their combined occurrence (15.2% vs. 17.5%, p = 0.49). The study was designed to detect a 10% difference in event rates; at 6 months, only a 2.3% difference was measured between groups, indicating an actual power of 0.19.
  
  
  CONCLUSIONS
  Early identification of low risk patients with MI allowed safe omission of the intensive care phase and noninvasive testing, and a day 3 hospital discharge strategy, resulting in substantial cost savings.
authors.affiliation: Division of Cardiology, William Beaumont Hospital, Royal Oak, MI 48073-6769, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Grines
authors.forename: D L
authors.initials: DL
authors.lastname: Marsalese
authors.forename: B
authors.initials: B
authors.lastname: Brodie
authors.forename: J
authors.initials: J
authors.lastname: Griffin
authors.forename: B
authors.initials: B
authors.lastname: Donohue
authors.forename: C R
authors.initials: CR
authors.lastname: Costantini
authors.forename: C
authors.initials: C
authors.lastname: Balestrini
authors.forename: G
authors.initials: G
authors.lastname: Stone
authors.forename: T
authors.initials: T
authors.lastname: Wharton
authors.forename: P
authors.initials: P
authors.lastname: Esente
authors.forename: M
authors.initials: M
authors.lastname: Spain
authors.forename: J
authors.initials: J
authors.lastname: Moses
authors.forename: M
authors.initials: M
authors.lastname: Nobuyoshi
authors.forename: M
authors.initials: M
authors.lastname: Ayres
authors.forename: D
authors.initials: D
authors.lastname: Jones
authors.forename: D
authors.initials: D
authors.lastname: Mason
authors.forename: D
authors.initials: D
authors.lastname: Sachs
authors.forename: L L
authors.initials: LL
authors.lastname: Grines
authors.forename: W
authors.initials: W
authors.lastname: O'Neill
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000191:economics / Q000592:standards; D001118:Argentina; D001938:Brazil; D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D005260:Female; D017721:Hospital Costs; D006761:Hospitals / Q000592:standards / Q000706:statistics & numerical data*; D006801:Humans; D007564:Japan; D007902:Length of Stay / Q000191:economics / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000191:economics / Q000628:therapy*; D018579:Patient Selection; D018570:Risk Assessment; D012449:Safety; D013030:Spain; D016896:Treatment Outcome; D014481:United States