Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine.
Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.
Silva
A E
AE
Hepatitis Studies Section, National Institutes of Health, Bethesda, Maryland, USA.
McMahon
B J
BJ
Parkinson
A J
AJ
Sjogren
M H
MH
Hoofnagle
J H
JH
Di Bisceglie
A M
AM
D004279:DNA, Viral / Q000032:analysis*; D006508:Hepatitis Antibodies / Q000302:isolation & purification*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology*; D006801:Humans
D004279:DNA, Viral; D006508:Hepatitis Antibodies; D006512:Hepatitis B Core Antigens; D017325:Hepatitis B Vaccines