title: Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine.
abstract: Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.
authors.affiliation: Hepatitis Studies Section, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Silva
authors.forename: B J
authors.initials: BJ
authors.lastname: McMahon
authors.forename: A J
authors.initials: AJ
authors.lastname: Parkinson
authors.forename: M H
authors.initials: MH
authors.lastname: Sjogren
authors.forename: J H
authors.initials: JH
authors.lastname: Hoofnagle
authors.forename: A M
authors.initials: AM
authors.lastname: Di Bisceglie
mesh_terms: D004279:DNA, Viral / Q000032:analysis*; D006508:Hepatitis Antibodies / Q000302:isolation & purification*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology*; D006801:Humans
chemical_list: D004279:DNA, Viral; D006508:Hepatitis Antibodies; D006512:Hepatitis B Core Antigens; D017325:Hepatitis B Vaccines