title: [Percutaneous ethanol and acetic acid injection for liver metastasis from colon cancer--two case reports].
abstract: Two cases of liver metastasis from colon cancer were treated by percutaneous ethanol (PEI) and acetic acid (PAI) injection for the recurrent lesion after surgery. Case 1 was a 60-year-old female who received sigmoidectomy with partial hepatectomy, and intraarterial 5-FU infusion was done after surgery. One year later, recurrence of liver tumor was detected, and PEI and PAI were performed for the metastatic lesions of the liver. Tumor regression and histopathological examination revealed coagulative necrosis. The patient died of lung metastasis 2 years and 10 months after treatment. Case 2 was a 58-year-old-male with ascending colon cancer and liver metastasis, who received surgery, and chemotherapy with intraarterial 5-FU infusion was continued. Four months later, recurrence of liver metastasis with elevation of serum CEA was noted. The patient received PEI three times and CEA decreased. Re-operation of hepatectomy revealed complete necrosis at the site of PEI. The patient has been alive for 1 year and 6 months with a new recurrence in the liver and is receiving repeated PEI therapy. PEI and PAI seem to be useful for the treatment of unresectable liver metastasis.
authors.affiliation: Dept. of Medicine, Kawasaki Medical School.
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Iguchi
authors.forename: N
authors.initials: N
authors.lastname: Shibata
authors.forename: M
authors.initials: M
authors.lastname: Takesue
authors.forename: T
authors.initials: T
authors.lastname: Tsunoda
authors.forename: K
authors.initials: K
authors.lastname: Sato
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage*; D002272:Carcinoembryonic Antigen / Q000097:blood; D012809:Colon, Sigmoid / Q000601:surgery; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged
chemical_list: D002272:Carcinoembryonic Antigen; D000431:Ethanol; D019342:Acetic Acid