title: Results from pelvic exenteration for locally advanced colorectal cancer with lymph node metastases.
abstract: OBJECTIVE
  We examined the survival benefit of pelvic exenteration for locally advanced colorectal cancer with lymph node metastases, because this issue remains controversial.
  
  
  METHODS
  Medical records of 50 patients who underwent curative pelvic exenteration for colorectal cancer were reviewed retrospectively. Nodal metastases were examined by the clearing method in 29 patients and by the conventional manual method in 21 patients.
  
  
  RESULTS
  Invasion to contiguous pelvic organs was present in 40 patients (80 percent) and absent in 10 patients (20 percent). Node metastases were present in 33 patients (66 percent). Operative morbidity and mortality rates were 22 percent (11 patients) and 6 percent (3 patients), respectively. Respective five-year survival rates were 60 and 80 percent in the groups with and without organ invasion (no significant difference). Five-year survival rates in patients with nodal metastases was 54.6 percent but was significantly higher, 82.4 percent, in patients without nodal metastases. Five-year survival in 28 patients with both organ invasion and nodal metastases was 53.6 percent.
  
  
  CONCLUSIONS
  Long-term survival was afforded by pelvic exenteration for locally advanced colorectal cancer with nodal metastases.
authors.affiliation: The First Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Hida
authors.forename: M
authors.initials: M
authors.lastname: Yasutomi
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
authors.forename: A
authors.initials: A
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: T
authors.initials: T
authors.lastname: Wakano
authors.forename: T
authors.initials: T
authors.lastname: Tokoro
authors.forename: K
authors.initials: K
authors.lastname: Fujimoto
mesh_terms: D015179:Colorectal Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D010385:Pelvic Exenteration; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate