QT corrected for heart rate and relation between QT and RR intervals in beagle dogs.
The beagle dog has been widely used in cardiovascular research, but the adequacy of QT prediction formulas in dogs over a wide range of RR intervals has not been evaluated sufficiently. We investigated the QT-RR relation in beagles by analysis of the QT and preceding RR intervals obtained from 24-h ambulatory electrocardiograms. The acceptability of 14 QT prediction formulas was evaluated by use of 100-150 selected pairs of QT-RR points per animal in seven male and seven female beagles. The accuracy of fit with the measured data was assessed according to the minimum Akaike information criterion. The best fit was given by the logarithmic and inverse Kovács' formulas among one- and two-parameter linear regression equations, respectively. Exponential formulas produced a better fit than did the linear regression formulas, but are impractical because of the complicated interpretation of parameters due to the nonlinearity. In addition, the results obtained under physiological conditions were also confirmed by those of the pharmacological intervention study with disopyramide. Consequently, we propose a one-parameter logarithmic formula (QTc= log600 x QT/logRR) for correcting the QT interval for a heart rate of 100 bpm and the inverse Kovács' formula for evaluating a reverse-use-dependency of QT prolongation.
Matsunaga
T
T
Toxicology Laboratory, Mochida Pharmaceutical, Co., Ltd., Fujieda, Shizuoka, Japan.
Mitsui
T
T
Harada
T
T
Inokuma
M
M
Murano
H
H
Shibutani
Y
Y
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D004195:Disease Models, Animal; D004206:Disopyramide / Q000494:pharmacology; D004285:Dogs; D015716:Electrocardiography, Ambulatory / Q000187:drug effects / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D016014:Linear Models; D008133:Long QT Syndrome / Q000139:chemically induced; D008297:Male; D015203:Reproducibility of Results
D000889:Anti-Arrhythmia Agents; D004206:Disopyramide