title: Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.
abstract: Chronic Fatigue Syndrome (CFS) has been widely studied and a lot of information is available in the literature regarding the immunological, virological, neuroendocrinal and psychiatric aspects of the disease, but its aetiology is still poorly understood. Great attention has also been paid to the alteration of the muscular function caused by CFS. The aim of the present work was to study CFS patients' gait in order to find out objective measures which can better characterize the pathology. Spatial and temporal parameters of gait were collected from a group of 12 CFS informed volunteers by using the typical instrumentation of movement analysis, and raw data were statistically elaborated. Comparisons with reference data from a population of healthy subjects revealed significant abnormalities in the symmetry indices of the bilateral parameters and in the linear relationships among parameters, and between these parameters and the physical characteristics of the patients. Interestingly, the abnormalities were present as from the beginning of the gait, which indicates that they are unlikely to be caused by the rapid increasing fatigue. This strengthens the hypothesis of a direct involvement of the central nervous system (CNS) in the onset of the disease.
authors.affiliation: Institute of Medical Pathophysiology, University G. D'Annunzio, Chieti, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Saggini
authors.forename: E
authors.initials: E
authors.lastname: Pizzigallo
authors.forename: J
authors.initials: J
authors.lastname: Vecchiet
authors.forename: V
authors.initials: V
authors.lastname: Macellari
authors.forename: C
authors.initials: C
authors.lastname: Giacomozzi
mesh_terms: D000328:Adult; D015673:Fatigue Syndrome, Chronic / Q000503:physiopathology*; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D015999:Multivariate Analysis; D012016:Reference Values; D012044:Regression Analysis; D013997:Time Factors