title: Cell proliferation control by Notch signaling in Drosophila development.
abstract: The Notch receptor mediates cell interactions controlling the developmental fate of a broad spectrum of undifferentiated cells. By modulating Notch signaling in specific precursor cells during Drosophila imaginal disc development, we demonstrate that Notch activity can influence cell proliferation. The activation of the Notch receptor in the wing disc induces the expression of the wing margin patterning genes vestigial and wingless, and strong mitotic activity. However, the effect of Notch signaling on cell proliferation is not the simple consequence of the upregulation of either vestigial or wingless. Vestigial and Wingless, on the contrary, display synergistic effects with Notch signaling, resulting in the stimulation of cell proliferation in imaginal discs.
authors.affiliation: Howard Hughes Medical Institute, Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536-0812, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Go
authors.forename: D S
authors.initials: DS
authors.lastname: Eastman
authors.forename: S
authors.initials: S
authors.lastname: Artavanis-Tsakonas
mesh_terms: D000818:Animals; D002450:Cell Communication; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008938:Mitosis; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics; D009687:Nuclear Proteins / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D051880:Receptors, Notch; D013489:Suppression, Genetic; D014921:Wings, Animal / Q000166:cytology / Q000196:embryology*; D051155:Wnt1 Protein
chemical_list: D029721:Drosophila Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D051155:Wnt1 Protein; C095064:vg protein, Drosophila; C074622:wg protein, Drosophila