title: Transformation of some pyrido[2,3-d]pyrimidine derivatives into other di- and triheterocyclic systems.
abstract: It was stated that three analogous ethyl 2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylates (7-9) react with hydrazine hydrate giving derivatives of the new heterocyclic system pyrido[2,3,4-ef]pyridazino[3,4-e]-1,2,4-triazepine (10-12), pyrido[3,4-d]pyridazine (16-18) and pentaazaphenalene (13-15). The latters were formed in low yields. The results of the preliminary pharmacological study of 2 of these compounds are reported.
authors.affiliation: Department of Chemistry of Drugs, Wrocław University of Medicine, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Sladowska
authors.forename: M
authors.initials: M
authors.lastname: Bodetko
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: G
authors.initials: G
authors.lastname: Rajtar
authors.forename: D
authors.initials: D
authors.lastname: Zółkowska
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared
chemical_list: D000700:Analgesics; D011743:Pyrimidines