Lack of protection from HIV infection by the mutant HIV coreceptor CCR5 in intravenously HIV infected hemophilia patients.
The CCR5 chemokine receptor is an important coreceptor for macrophage-tropic HIV strains. Homozygous carriers of the mutated CCR5 receptor with a 32 bp deletion (delta 32-CCR5) are highly protected against HIV infection. A protective effect has also been described for heterozygous individuals carrying both mutated and wildtype CCR5 receptors. We compared the frequency of the mutated delta 32-CCR5 HIV coreceptor in HIV positive patients infected by sexual contact (N = 160) with intravenously HIV infected hemophilic patients (N = 84) and HIV negative individuals (N = 421). We found no protective effect of delta 32-CCR5 HIV coreceptor in hemophilic patients (p = 0.0134). If proteins of plasma concentrates would be responsible for facilitating the entry of HIV macrophages by upregulation of the CCR5 wildtype receptor it would be of therapeutical interest to identify the responsible plasma proteins.
Malo
A
A
Institut für Immunologie, Universität München, Germany.
Rommel
F
F
Bogner
J
J
Gruber
R
R
Schramm
W
W
Goebel
F D
FD
Riethmüller
G
G
Wank
R
R
D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology; D006467:Hemophilia A / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D010641:Phenotype; D019713:Receptors, CCR5 / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D019707:Receptors, Chemokine / Q000235:genetics / Q000276:immunology; D015728:Receptors, HIV / Q000235:genetics / Q000276:immunology*
D019713:Receptors, CCR5; D019707:Receptors, Chemokine; D015728:Receptors, HIV