title: Obstetric and perinatal outcome after oocyte donation: comparison with in-vitro fertilization pregnancies.
abstract: The obstetric and perinatal outcome in 51 oocyte donation pregnancies (61 infants) was compared with that of a control group of standard in-vitro fertilization (IVF) patients (97 pregnancies, 126 infants). The oocyte recipients (mean +/- SD age 33.5+/-4.7 years) included 39 women with ovarian failure and 12 women with functioning ovaries. In oocyte recipients, first trimester bleeding (53%) occurred significantly more often than in IVF mothers (31%, P < 0.01). Pregnancy-induced hypertension was observed in 31% of oocyte recipients compared with 14% in IVF mothers (P < 0.05). There was no difference in the duration of pregnancies or in the preterm delivery rate between the two groups. When restricting analysis to singleton pregnancies, 63% of oocyte recipients were hospitalized in the antenatal period compared with 29% in the IVF group (P < 0.001). The Caesarean section rate was 57% in the oocyte donation group and 37% in the IVF group (P < 0.05). Birthweight in singleton pregnancies was similar in both groups. The perinatal mortality rate was 3.3% in the oocyte donation group and 0% in the IVF group. In conclusion, oocyte donation pregnancies are associated with an increased risk compared with IVF pregnancies, but the complications are usually manageable and most oocyte recipients experience a good pregnancy outcome.
authors.affiliation: Infertility Clinic, The Family Federation of Finland, Helsinki.
authors.forename: V
authors.initials: V
authors.lastname: Söderström-Anttila
authors.forename: A
authors.initials: A
authors.lastname: Tiitinen
authors.forename: T
authors.initials: T
authors.lastname: Foudila
authors.forename: O
authors.initials: O
authors.lastname: Hovatta
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D002585:Cesarean Section; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007231:Infant, Newborn; D018587:Oocyte Donation / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology; D011256:Pregnancy Outcome; D014592:Uterine Hemorrhage / Q000209:etiology