title: Induced diarrhoea in horses. Part 1: Fluid and electrolyte balance.
abstract: Sodium, potassium and water balance, and measurements of acid-base status, haematocrit, packed cell volume and plasma total protein, were studied in four adult standardbred geldings following castor oil induced diarrhoea. Castor oil (2 mL kg-1) administration resulted in signs consistent with mild to moderate acute colitis. The total (combined faecal and urinary losses) losses of sodium and potassium ions were 2169 and 2864 mmol, respectively. Faeces constituted the major route for sodium loss, while urine was the major route for potassium loss at all times. Faecal dry matter potassium concentration did not vary significantly at any stage. Faecal dry matter sodium concentration increased significantly, coinciding with the onset of clinical diarrhoea. Faecal water loss increased significantly from 2.15 +/- 0.44 mL kg-1 h-1 to 5.15 +/- 0.92 mL kg-1 h-1 while clinical diarrhoea was observed. While plasma volume (PV) did not vary significantly in this study, there was a trend for PV to decrease while horses were clinically dehydrated.
authors.affiliation: Rural Veterinary Centre, University of Sydney, Camden, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Ecke
authors.forename: D R
authors.initials: DR
authors.lastname: Hodgson
authors.forename: R J
authors.initials: RJ
authors.lastname: Rose
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002368:Castor Oil; D003681:Dehydration / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary; D003967:Diarrhea / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*; D004573:Electrolytes / Q000652:urine; D006400:Hematocrit; D006734:Horse Diseases; D006736:Horses; D008297:Male; D009919:Orchiectomy; D014882:Water-Electrolyte Balance
chemical_list: D001798:Blood Proteins; D004573:Electrolytes; D002368:Castor Oil