title: Uncertainty and variability analysis in multiplicative risk models.
abstract: Currently, there is a trend away from the use of single (often conservative) estimates of risk to summarize the results of risk analyses in favor of stochastic methods which provide a more complete characterization of risk. The use of such stochastic methods leads to a distribution of possible values of risk, taking into account both uncertainty and variability in all of the factors affecting risk. In this article, we propose a general framework for the analysis of uncertainty and variability for use in the commonly encountered case of multireplicative risk models, in which risk may be expressed as a product of two or more risk factors. Our analytical methods facilitate the evaluation of overall uncertainty and variability in risk assessment, as well as the contributions of individual risk factors to both uncertainty and variability which is cumbersome using Monte Carlo methods. The use of these methods is illustrated in the analysis of potential cancer risks due to the ingestion of radon in drinking water.
authors.affiliation: Health Canada, Ottawa, Ontario, Canada.
authors.forename: S N
authors.initials: SN
authors.lastname: Rai
authors.forename: D
authors.initials: D
authors.lastname: Krewski
mesh_terms: D000704:Analysis of Variance; D006801:Humans; D015233:Models, Statistical; D009010:Monte Carlo Method; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D011886:Radon / Q000009:adverse effects; D012306:Risk; D012307:Risk Factors; D013269:Stochastic Processes; D014875:Water Pollutants, Radioactive / Q000009:adverse effects
chemical_list: D014875:Water Pollutants, Radioactive; D011886:Radon