title: [Absence of frontal lobe dysfunction and working memory deficits in young schizophrenic patients].
abstract: The impairment in tasks requiring intact frontal lobe functions has been repeatedly shown in schizophrenics. However, the relative roles of confounding factors, like duration of the disease, social withdrawal, or antidopaminergic medication, are not clearly demonstrated. We studied the performance of 12 young active patients, with chronic residual schizophrenia that had recent onset, and 12 control subjects, with frontal lobe tests and with a battery designed to explore working memory. The results show normal performance in schizophrenia. The small number of patients does not allow definitive conclusions, but this study suggests that a frontal dysfunction may not be present early in the evolution of schizophrenia in active patients.
authors.affiliation: Service Neurologie et Neuropsychologie, CHRU, Grenoble.
authors.forename: O
authors.initials: O
authors.lastname: Moreaud
authors.forename: I
authors.initials: I
authors.lastname: Peguet
authors.forename: B
authors.initials: B
authors.lastname: Naegele
authors.forename: T
authors.initials: T
authors.lastname: Vincent
authors.forename: J P
authors.initials: JP
authors.lastname: Chabannes
authors.forename: J
authors.initials: J
authors.lastname: Pellat
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology