title: The microcirculation in venous hypertension.
abstract: Venous ulceration is a common problem in western countries and results in large costs to healthcare systems. A number of hypotheses of the mechanisms of development of venous ulceration have been advanced, but this question has not been fully resolved. In recent years research effort has focused on the microcirculation of the skin and many methods of investigation have been employed to study this. Some of the principal findings described in published work are reviewed in this article. It seems unlikely from the available evidence that venous ulceration is attributable solely to failure of diffusion of oxygen and other small nutritional molecules to the tissues of the skin. The microvascular changes in the skin are characterised by activated endothelium and perivascular inflammatory cells. It is much more likely that leucocytes attach themselves to the cutaneous microcirculation, become activated and produce endothelial injury. Repeated over many months or years, this chronic inflammatory process leads to be tissues changes of lipodermatosclerosis. Although there is evidence of leucocyte involvement in the pathogenesis of venous ulceration, the exact mechanisms remain to be resolved. Improved treatment for patients may be devised once a better understanding of the basic causes of this condition has been reached.
authors.affiliation: Department of Surgery, UCL Medical School, Middlesex Hospital, London, UK.
authors.forename: P D
authors.initials: PD
authors.lastname: Coleridge Smith
mesh_terms: D001785:Blood Gas Monitoring, Transcutaneous; D017078:Laser-Doppler Flowmetry; D007866:Leg / Q000098:blood supply; D008833:Microcirculation / Q000502:physiology; D014463:Ultrasonography; D014648:Varicose Veins / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014690:Venous Pressure / Q000502:physiology*