Phagomimetic action of antimicrobial agents.
A wide variety of extracted and synthesised drug molecules have electron transfer capabilities which allow them to generate reactive oxygen species (ROS). In particular, many antibiotics that kill or inhibit bacteria, yeasts and cancer cells readily transfer electrons to oxygen making superoxide and hydrogen peroxide in the process. When suitable redox active forms of iron are available, Fenton chemistry occurs generating the highly damaging hydroxyl radical. This type of chemistry is very similar to that which evolved within phagocytic cells as part of their microbial killing armoury. Many antibiotics, when used in model systems, have well defined pharmacological actions against key cellular functions, but their clinical usefulness is also often demonstrable at concentrations in vivo well below their in vitro minimum inhibitory concentrations. These observations have led us to propose that a common mechanism exists whereby phagocytic cells and antibiotics exploit the use of ROS for microbial killing.
Gutteridge
J M
JM
Oxygen Chemistry Laboratory, Unit of Critical Care, Royal Brompton Hospital, London, UK.
Quinlan
G J
GJ
Kovacic
P
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology / Q000627:therapeutic use; D004579:Electron Transport; D006801:Humans; D010587:Phagocytosis; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D017382:Reactive Oxygen Species