An academic centre for gene therapy research with clinical grade manufacturing capability.
Huddinge University Hospital is a major teaching hospital affiliated with the Karolinska Institute in Southern Stockholm. For the past few years several groups have been working there in different areas of gene therapy relating to cancer, genetic and infectious diseases. However, a facility to produce clinical grade material under good manufacturing practice was lacking. To this end, Huddinge University Hospital has taken the initiative to open a Gene Therapy Research Center in 1996. This facility, which is unique of its kind in Scandinavia, is located in the Novum Research Park, Huddinge, and is a part of the existing Clinical Research Center. The newly built centre will allow clinicians and researchers to develop and produce vectors (viral and nonviral) for clinical trials and do basic research to understand the mechanisms of diseases. Although the centre will primarily serve the academic institutions it will also extend its facilities to other investigators in this field. The production unit is run in collaboration with the Faculty of Medicine, University of Lund. On-going projects include production of plasmid vectors for prevention of postangioplasty restenosis, DNA vaccine for HIV-1, cationic liposome DNA complexes for cystic fibrosis and retroviral vectors for HIV-1.
Islam
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Center for Gene Therapy Research, Huddinge University Hospital, Karolinska Institute, Sweden. Khalid.Islam@kfcmail.hs.sll.se
Blomberg
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Wikström
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Smith
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D016915:AIDS Vaccines; D000046:Academic Medical Centers; D000800:Angioplasty, Balloon; D001157:Arterial Occlusive Diseases / Q000517:prevention & control / Q000628:therapy; D002986:Clinical Trials as Topic; D003141:Communicable Diseases / Q000628:therapy; D003550:Cystic Fibrosis / Q000628:therapy; D030342:Genetic Diseases, Inborn / Q000628:therapy; D015316:Genetic Therapy; D005822:Genetic Vectors; D015497:HIV-1 / Q000235:genetics / Q000276:immunology; D006784:Hospitals, Teaching; D006801:Humans; D007373:Interinstitutional Relations; D009369:Neoplasms / Q000628:therapy; D010957:Plasmids; D012008:Recurrence; D012106:Research; D012190:Retroviridae / Q000235:genetics; D012577:Schools, Medical; D013548:Sweden; D014614:Vaccines, Synthetic
D016915:AIDS Vaccines; D014614:Vaccines, Synthetic