title: An engineering model of dynamic cardiomyoplasty. II. Clinical applications.
abstract: Previously, a modification to the Sunagawa engineering model for the isolated left ventricle and arterial system was proposed and validated for dynamic cardiomyoplasty in an acute goat preparation. To test the hypothesis that this model may be applied to the clinical scenario in cardiomyoplasty patients, we predicted human stroke volume using the model with human clinical data from the literature. Predicted stroke volume correlated well with published stroke volume in patients who have had the dynamic cardiomyoplasty procedure. These results suggest that the modest hemodynamic improvement commonly reported after the procedure is performed may be due to diminished latissimus dorsi strength after transformation. The validity of both the original Sunagawa model and the previously proposed modification for dynamic cardiomyoplasty is further supported with these results. A nomogram methodology for predicting stroke volume after dynamic cardiomyoplasty for any particular patient is presented.
authors.affiliation: Division of Engineering and Applied Sciences, Harvard Graduate School of the Arts and Sciences, Cambridge, MA, USA.
authors.forename: F Y
authors.initials: FY
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Aklog
authors.forename: B J
authors.initials: BJ
authors.lastname: deGuzman
authors.forename: R M
authors.initials: RM
authors.lastname: Ahmad
authors.forename: R G
authors.initials: RG
authors.lastname: Laurence
authors.forename: G S
authors.initials: GS
authors.lastname: Couper
authors.forename: L H
authors.initials: LH
authors.lastname: Cohn
authors.forename: T A
authors.initials: TA
authors.lastname: McMahon
mesh_terms: D001696:Biomechanical Phenomena; D018421:Cardiomyoplasty / Q000379:methods*; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008955:Models, Cardiovascular; D013318:Stroke Volume