Correlation between plasma levels of cytokines and HIV-1 RNA copy number in HIV-infected patients.
The plasma levels of HIV-1 RNA, tumor necrosis factor alpha (TNF-alpha), soluble receptors type II of TNF-alpha (sTNF-alpha RII), soluble receptors of interleukin-4 (sR IL-4), interleukin-6 (IL-6), soluble receptors of interleukin-6 (sR IL-6), granulocyte macrophage colony stimulating factor (GM-CSF), soluble receptors of GM-CSF (sR GM-CSF), RANTES, MIP-1 alpha and MIP-1 beta were measured in 80 HIV-infected patients. All patients had not been treated previously with antiretroviral drugs and did not present a recent history of opportunistic infection. A statistically significant correlation was found between HIV-1 RNA and TNF-alpha (p = 0.005) or sTNF-alpha RII levels (p < 0.001). RANTES and MIP-1 alpha levels did not correlate with HIV-1 RNA. MIP-1 beta levels were correlated with plasma RNA titers in patients with CD4+ T cells < 200 x 10(6)/l (p = 0.03). MIP-1 alpha and sR IL-4 levels were significantly different according to the CD4+ T cell range (p = 0.003 and p = 0.0002, respectively). GM-CSF and sR GM-CSF were undetectable in each case. These data confirm that HIV-1 replication in the plasma is correlated with TNF-alpha levels, but do not show a clear correlation with levels of the chemokines studied.
Hittinger
G
G
Dept. of Infectious Diseases, Hôpital Chalucet, Toulon, France.
Poggi
C
C
Delbeke
E
E
Profizi
N
N
Lafeuillade
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000821:virology; D000328:Adult; D018791:CD4 Lymphocyte Count; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000097:blood; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007378:Interleukins / Q000097:blood; D019402:Macrophage Inflammatory Proteins / Q000097:blood; D008297:Male; D012367:RNA, Viral / Q000097:blood*; D018123:Receptors, Interleukin / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D054407:Chemokine CCL4; D018946:Chemokine CCL5; D016207:Cytokines; D007378:Interleukins; D019402:Macrophage Inflammatory Proteins; D012367:RNA, Viral; D018123:Receptors, Interleukin; D014409:Tumor Necrosis Factor-alpha