Refractory hyperglycemia complicating an evolving connective tissue disease: response to cyclosporine.
A 33-year-old woman with longstanding rheumatoid arthritis and Sjögren's syndrome developed type B insulin resistance (diabetes mellitus due to anti-insulin receptor antibodies) simultaneous with the evolution of her rheumatic disease to mixed connective tissue disease. Cyclosporine therapy induced a remission of receptor antibody mediated insulin resistance and controlled clinical manifestations of her systemic lupus erythematosus and dermatomyositis, but had no effect on the sclerodermatous features of her illness.
Kramer
N
N
Arthritis and Rheumatic Disease Center, Department of Medicine, St. Barnabas Medical Center, Livingston, NJ 07039, USA.
Rosenstein
E D
ED
Schneider
G
G
D000328:Adult; D000906:Antibodies / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D007333:Insulin Resistance / Q000276:immunology; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D011972:Receptor, Insulin / Q000276:immunology
D000906:Antibodies; D016572:Cyclosporine; D011972:Receptor, Insulin