title: Gabapentin does not interact with a contraceptive regimen of norethindrone acetate and ethinyl estradiol.
abstract: Anticonvulsants that induce hepatic metabolism increase clearance of oral contraceptive hormones and thereby cause contraceptive failure. Gabapentin is not metabolized in humans and has little liability for causing metabolic-based drug-drug interactions. In healthy women receiving 2.5 mg norethindrone acetate and 50 microg ethinyl estradiol daily for three consecutive menstrual cycles, concurrent gabapentin administration did not alter the steady-state pharmacokinetics of either hormone. Thus, gabapentin is unlikely to cause contraceptive failure.
authors.affiliation: Department of Clinical Pharmacology, Parke-Davis, Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Eldon
authors.forename: B A
authors.initials: BA
authors.lastname: Underwood
authors.forename: E J
authors.initials: EJ
authors.lastname: Randinitis
authors.forename: A J
authors.initials: AJ
authors.lastname: Sedman
mesh_terms: D000085:Acetates / Q000493:pharmacokinetics*; D000293:Adolescent; D000328:Adult; D000588:Amines; D000927:Anticonvulsants / Q000493:pharmacokinetics*; D003280:Contraceptives, Oral, Synthetic / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D003509:Cyclohexanecarboxylic Acids; D004347:Drug Interactions; D045166:Estradiol Congeners / Q000493:pharmacokinetics*; D004997:Ethinyl Estradiol / Q000493:pharmacokinetics*; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008875:Middle Aged; D009640:Norethindrone / Q000493:pharmacokinetics*; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003280:Contraceptives, Oral, Synthetic; D003509:Cyclohexanecarboxylic Acids; D045166:Estradiol Congeners; D004997:Ethinyl Estradiol; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D009640:Norethindrone