Protective effect of picroliv, active constituent of Picrorhiza kurrooa, against oxytetracycline induced hepatic damage.
Picroliv, the active constituent of P. kurrooa, showed a dose dependent (1.5-12 mg/kg, po for 7 days) hepatoprotective activity against oxytetracycline induced hepatic damage in rat. It increased the number of viable hepatocytes (ex-vivo) significantly. Increase in bile volume and its contents in conscious rat suggests potent anticholestatic property. Picroliv also antagonised alterations in enzyme levels (GOT, GPT, and alkaline phosphatase) in isolated hepatocytes and serum, induced by oxytetracycline (200 mg/kg, i.p.) feeding. Picroliv was more potent than silymarin a known hepatoprotective drug.
Saraswat
B
B
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Reserach Institute, Lucknow, India.
Visen
P K
PK
Patnaik
G K
GK
Dhawan
B N
BN
D000818:Animals; D002934:Cinnamates / Q000494:pharmacology*; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D007194:India; D008099:Liver / Q000187:drug effects*; D008297:Male; D010118:Oxytetracycline / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012838:Silymarin / Q000494:pharmacology; D014641:Vanillic Acid / Q000494:pharmacology*
D002934:Cinnamates; D006027:Glycosides; D010936:Plant Extracts; D012838:Silymarin; C057463:kutkin; D014641:Vanillic Acid; D010118:Oxytetracycline