title: Effect of nimodipine on the cognitive dysfunction induced by phenytoin and valproate in rats.
abstract: Anticonvulsant effects of phenytoin (PHT) and valproate (VPA) were studied alone and in combination with nimodipine (NMD) against maximal electroshock (MES)-induced seizures in rats. PHT and VPA induce cognitive deficit in terms of long-term memory loss. The effect of NMD on the cognitive deficit induced by PHT and VPA was studied through the step-through passive avoidance test (PAT). It was seen that there was a potentiation of antielectroshock effect of PHT and VPA when NMD at a dose of 4 mg/kg was combined with PHT or VPA. NMD reversed the long-term memory loss induced by PHT and VPA in the PAT.
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
authors.forename: S
authors.initials: S
authors.lastname: Balakrishnan
authors.forename: P
authors.initials: P
authors.lastname: Pandhi
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D005260:Female; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D009553:Nimodipine / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D009553:Nimodipine; D014635:Valproic Acid; D010672:Phenytoin