title: Effects of hepatic portal infusion of deionized water on metabolic and hormonal responses to exercise in rats.
abstract: The present study was conducted to investigate the in vivo effects of an intrahepatic infusion of deionized water during exercise in rats. Adrenodemedullated male Sprague-Dawley rats were continuously infused for 30 min either at rest or during treadmill exercise (26 m/min, 0% grade). Rats were randomly assigned to one of three infusion conditions (52 micro ul/min) with either deionized water (PW) or saline (PS; NaCl; 0.9%) via the hepatic portal vein or deionized water through the jugular vein (JW). The exercise period caused a significant (P < 0.05) decrease in liver glycogen and relative liver water content and peripheral and portal blood glucose and insulin while increasing peripheral and portal glucagon and K+ plasma concentrations. These responses, with the exception of K+, were not influenced by the different types of infusions. The increase in K+ during exercise was significantly (P < 0.05) higher in JW rats than in the PW and PS groups. Both the infusion and exercise protocols did not significantly alter the liver weight-to-body weight ratio, plasma osmolality, free fatty acids, beta-hydroxybutyrate, Na+, Cl-, vasopressin, and catecholamine concentrations. It is concluded that an hepatic portal infusion of deionized water does not specifically alter the metabolic and hormonal responses to exercise in rats.
authors.affiliation: Departement d'Education Physique, Université de Montréal, Québec, Canada.
authors.forename: M G
authors.initials: MG
authors.lastname: Latour
authors.forename: F
authors.initials: F
authors.lastname: Désy
authors.forename: C
authors.initials: C
authors.lastname: Warren
authors.forename: J M
authors.initials: JM
authors.lastname: Lavoie
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D004573:Electrolytes / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D005934:Glucagon / Q000097:blood; D007038:Hypotonic Solutions / Q000494:pharmacology; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000502:physiology*; D008297:Male; D009929:Organ Size / Q000502:physiology; D009994:Osmolar Concentration; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011169:Portal Vein / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D004573:Electrolytes; D005227:Fatty Acids; D007038:Hypotonic Solutions; D007328:Insulin; D014867:Water; D019344:Lactic Acid; D005934:Glucagon; D004837:Epinephrine