title: Distinctive dermatoscopic features of acral lentiginous melanoma in situ from plantar melanocytic nevi and their histopathologic correlation.
abstract: BACKGROUND
  An acral lentiginous melanoma in situ on the sole is often difficult to differentiate with the naked eye from an acquired plantar melanocytic nevus. Recent technical advances in epiluminescence microscopy have contributed to the differentiation of these two pigmented skin lesions.
  
  
  OBJECTIVE
  In this study, the correlation between dermatoscopic and histopathologic findings of acral lentiginous melanoma in situ on the sole are compared to those of acquired plantar melanocytic nevi.
  
  
  METHODS
  Three acral lentiginous melanomas in situ on the sole, and two cases of acral lentiginous melanoma were compared with 50 acquired plantar melanocytic nevi by means of dermatoscopy and histopathology.
  
  
  RESULTS
  The dermatoscopic surface profiles of acquired melanocytic nevi were composed of linear pigmentation accentuated mainly on the sulcus superficialis. Histologically, some areas of the sulcus superficialis corresponded to rete ridges of the epidermis, and nests of nevus cells were also often located there. In contrast, the acral lentiginous melanomas in situ showed diffuse, irregularly shaped pigmentation distributed in a disorderly fashion over the entire surface. Histologically, isolated areas of proliferation and small nest formations of atypical melanocytes were irregularly distributed in the epidermis.
  
  
  CONCLUSIONS
  A distinctive dermatoscopic feature of acral lentiginous melanoma in situ is diffuse and irregular pigmentation over the entire surface of the lesion. This feature is helpful for differentiating acral lentiginous melanoma in situ from acquired plantar melanocytic nevi.
authors.affiliation: University of Tokyo, Faculty of Medicine, Department of Dermatology, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawabata
authors.forename: K
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D002278:Carcinoma in Situ / Q000145:classification / Q000473:pathology*; D003937:Diagnosis, Differential; D005534:Foot Diseases / Q000473:pathology*; D006801:Humans; D008545:Melanoma / Q000145:classification / Q000473:pathology*; D008853:Microscopy / Q000379:methods; D009508:Nevus, Pigmented / Q000145:classification / Q000473:pathology*; D012878:Skin Neoplasms / Q000145:classification / Q000473:pathology*