Cerebral vasculitis during FK 506 treatment in a liver transplant patient.
The immunosuppressive agent FK 506 is widely used in liver transplant patients. Neurotoxicity is a major complication of its use. We report progressive and irreversible neurologic complications occurring in a 39-year-old woman who underwent liver transplantation and was treated with FK 506. Neuropathologic examination revealed multiple vasculitic lesions. The possibility of an FK 506-mediated toxic effect on the cerebral vessels is suggested.
Pizzolato
G P
GP
Division of Clinical Pathology, Geneva University Hospital, Switzerland.
Sztajzel
R
R
Burkhardt
K
K
Megret
M
M
Borisch
B
B
D000328:Adult; D002536:Cerebral Arteries / Q000473:pathology*; D002560:Cerebrovascular Circulation; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000633:toxicity*; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging; D009498:Neurotoxins / Q000009:adverse effects; D016559:Tacrolimus / Q000633:toxicity*; D014657:Vasculitis / Q000139:chemically induced* / Q000175:diagnosis
D007166:Immunosuppressive Agents; D009498:Neurotoxins; D016559:Tacrolimus