title: Nothramicin, a new anthracycline antibiotic from Nocardia sp. MJ896-43F17.
abstract: A new antibiotic designated nothramicin was isolated from the culture broth of Nocardia sp. MJ896-43F17 which was closely related to Nocardia brasiliensis. It was isolated by the Diaion HP-20 column chromatography, butyl acetate extraction and purified by HPLC. It inhibited the growth of mycobacteria at the concentration of 1.56 approximately 25 microg/ml. Nothramicin was revealed to be a new member of anthracycline antibiotics by the various spectroscopies.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Momose
authors.forename: N
authors.initials: N
authors.lastname: Kinoshita
authors.forename: R
authors.initials: R
authors.lastname: Sawa
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
authors.forename: H
authors.initials: H
authors.lastname: Iinuma
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009615:Nocardia
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C111762:nothramicin