title: Massive hepatosplenomegaly, jaundice and pancytopenia in miliary tuberculosis.
abstract: A 29-year-old Caucasian woman presented to hospital with a 2-day history of diarrhoea, anorexia and rigors. Investigations showed abnormal liver function tests, hyponatremia, hypoalbuminaemia and lymphopenia. The initial chest radiograph was normal. A bone marrow trephine biopsy showed non-caseating granulomata and she subsequently developed miliary shadowing on the chest radiograph. A transjugular liver biopsy confirmed the presence of acid-alcohol fast bacilli. Despite starting triple therapy for miliary tuberculosis she remained febrile and developed massive hepatosplenomegaly, jaundice and pancytopenia. Standard triple therapy was substituted with ethambutol, streptomycin and oral prednisolone and the patient made a dramatic recovery. The clinical symptoms of miliary tuberculosis are frequently non-specific and the onset of the illness is often insidious. The liver is involved in almost all patients with miliary tuberculosis, but massive hepatosplenomegaly and jaundice are rare. Standard triple-therapy should be discontinued when there is significant liver dysfunction, and corticosteroids should be considered for patients with miliary tuberculosis who fail to respond to conventional therapy.
authors.affiliation: Department of Medicine & Infectious Diseases, University Hospital of Wales, Cardiff, UK.
authors.forename: R H
authors.initials: RH
authors.lastname: Evans
authors.forename: M
authors.initials: M
authors.lastname: Evans
authors.forename: N K
authors.initials: NK
authors.lastname: Harrison
authors.forename: D E
authors.initials: DE
authors.lastname: Price
authors.forename: A R
authors.initials: AR
authors.lastname: Freedman
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006529:Hepatomegaly / Q000209:etiology*; D006801:Humans; D007565:Jaundice / Q000209:etiology*; D008099:Liver / Q000473:pathology; D010198:Pancytopenia / Q000209:etiology*; D013163:Splenomegaly / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014391:Tuberculosis, Miliary / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D000995:Antitubercular Agents