[Drug delivery system for infectious diseases].
Various types of antimicrobial agents have been evolved to inhibit growth of or to kill different microorganisms. In recent years, encapsulation of antimicrobial agents in lipid formulations has been a popular practice in research work related to drug delivery system, although most of the studies are based primary on animal models. The recent developments of lipid formulations of anti-infectious drug (antibiotics, antifungals, and antiviral agents) with longer half-life opens new therapeutic avenues in treating infections. The passive targeting of liposomes to the sites of infection is of great value with respect to clinical application. Liposome entrapment can exchange their pharmacokinetics and, hence reduce their toxicity.
Maesaki
S
S
Second Department of Internal Medicine, Nagasaki University School of Medicine.
Kohno
S
S
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000382:microbiology; D008081:Liposomes
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes