Biological activities of (1-->3)-beta-D-glucans with reducing glucose side chains.
Newly synthesized (1-->3)-beta-D-glucans with reducing glucose side chains (6-O-glucopyranosylated curdlan and 3-O-glucopyranosylated curdlan, with glucose linked directly (except for anomeric carbon) had antitumor activity against mice sarcoma 180 in mice. The two glucans potentiated the reticuloendotheliai system and activated macrophages (increased their glucose consumption). The activity inducing tumor regressing factor of the glucan derivatives was stronger than a linear (1-->3)-beta-D-glucan (curdlan).
Kiho
T
T
Department of Hygienic Chemistry, Gifu Pharmaceutical University, Japan.
Matsushita
M
M
Usui
S
S
Ukai
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005936:Glucans / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction; D012510:Sarcoma 180 / Q000188:drug therapy; D047071:beta-Glucans
C112066:3-O-glucopyranosylated curdlan; C112067:6-O-glucopyranosylated curdlan; D000970:Antineoplastic Agents; D005936:Glucans; D047071:beta-Glucans