Regulation of G1 progression in fission yeast by the rum1+ gene product.
Recently it has been found that B-type cyclins in fission yeast regulate the activation of the cdc2 kinase to promote the onset of both DNA replication and mitosis. cig2 is the major G1 cyclin while cdc13 is the principal mitotic cyclin. cdc13 also has an additional function in G2 phase, preventing more than one round of DNA replication per cell cycle. In opposition to these cyclins the rum1 inhibitor, a protein present exclusively in G1, prevents premature activation of the cdc2/cig2 and the cdc2/cdc13 complexes until cells have reached the critical cell size required to pass Start and initiate a new cell cycle.
Martín-Castellanos
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Departamento de Microbiología y Genética, CSIC/Universidad de Salamanca, Spain.
Moreno
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D018797:Cell Cycle Proteins; D019926:Cyclin B; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors; D016213:Cyclins / Q000235:genetics / Q000502:physiology; D004261:DNA Replication; D004791:Enzyme Inhibitors / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology*; D016193:G1 Phase / Q000235:genetics / Q000502:physiology*; D005800:Genes, Fungal; D008954:Models, Biological; D012568:Schizosaccharomyces / Q000235:genetics / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins
D018797:Cell Cycle Proteins; C080328:Cig2 protein, S pombe; D019926:Cyclin B; D016213:Cyclins; D004791:Enzyme Inhibitors; D005656:Fungal Proteins; C086077:Rum1 protein, S pombe; D029702:Schizosaccharomyces pombe Proteins; D018844:Cyclin-Dependent Kinases