A gene for familial juvenile polyposis maps to chromosome 18q21.1.
Familial juvenile polyposis (FJP) is a hamartomatouspolyposis syndrome in which affected family members develop upper and lower gastrointestinal juvenile polyps and are at increased risk for gastrointestinal cancer. A genetic locus for FJP has not yet been identified by linkage; therefore, the objective of this study was to perform a focused genome screen in a large family segregating FJP. No evidence for linkage was found with markers near MSH2, MLH1, MCC, APC, HMPS, CDKN2A, JP1, PTEN, KRAS2, TP53, or LKB1. Linkage to FJP was established with several markers from chromosome 18q21.1. The maximum LOD score was 5.00, with marker D18S1099 (recombination fraction of .001). Analysis of critical recombinants places the FJP gene in an 11.9-cM interval bounded by D18S1118 and D18S487, a region that also contains the tumor-suppressor genes DCC and DPC4. These data demonstrate localization of a gene for FJP to chromosome 18q21.1 by linkage, and they raise the possibility that either DCC or DPC4 could be responsible for FJP.
Howe
J R
JR
Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242-1086, USA. james-howe@uiowa.edu
Ringold
J C
JC
Summers
R W
RW
Mitros
F A
FA
Nishimura
D Y
DY
Stone
E M
EM
D000293:Adolescent; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D005260:Female; D008040:Genetic Linkage; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree