title: Gingival inflammation and subgingival calculus as determinants of disease progression in early-onset periodontitis.
abstract: This study was undertaken to test the hypothesis that gingival inflammation and dental calculus are important determinants of the development and progression of early-onset periodontitis. The study sample included 156 individuals who were 13-20 years old at baseline and who were examined 2x during 6 years to assess the attachment loss, gingival state and the presence of dental calculus. 33 (21%), 62 (40%), and 61 (39%) individuals were classified as having localized, generalized, or incidental EOP, respectively. The results showed an increase in the % of teeth with overt gingivitis and subgingival calculus, and also an increase in the % of teeth showing attachment loss during the 6-year period in all classification groups. Of teeth with 0-2 mm attachment loss at the beginning of the study and which developed > or = 3 mm attachment loss during the following 6 years, there were 2x as many teeth with overt gingival inflammation, and 4x more teeth with subgingival calculus at baseline than teeth without. Gingivitis and subgingival calculus when present at both examinations resulted in a stronger association with the development of new lesions than presence of these variables at baseline. Teeth with gingivitis at baseline had a significantly higher mean attachment loss during 6 years than teeth without gingivitis (p<0.0001), and teeth with subgingival calculus at baseline had a significantly higher mean attachment loss than teeth without subgingival calculus (p<0.0001). The presence of gingivitis and subgingival calculus at baseline and 6 years later was associated with the occurrence of even higher disease progression during this period. The association between gingival inflammation and subgingival calculus and the development and progression of attachment loss during the study period in the generalized and the localized EOP groups was significantly higher than the association in the incidental EOP group. In an appreciable % of the sites in all 3 groups, however, the presence of the 2 factors was not associated with attachment loss during 6 years. The results suggest a significant association between gingival inflammation and subgingival calculus and the development and progression of early-onset periodontitis.
authors.affiliation: National Institute of Dental Research, Bethesda, Maryland 20892-6401, USA. ALBANDARJ@DE45.NIDR.NIH.GOV
authors.forename: J M
authors.initials: JM
authors.lastname: Albandar
authors.forename: A
authors.initials: A
authors.lastname: Kingman
authors.forename: L J
authors.initials: LJ
authors.lastname: Brown
authors.forename: H
authors.initials: H
authors.lastname: Löe
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000209:etiology / Q000503:physiopathology*; D003728:Dental Calculus / Q000150:complications*; D018450:Disease Progression; D005260:Female; D005891:Gingivitis / Q000150:complications*; D006801:Humans; D016014:Linear Models; D008297:Male; D017622:Periodontal Attachment Loss / Q000175:diagnosis; D010512:Periodontal Index; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012307:Risk Factors