title: Nonfunctioning adrenal cortical cancer and analysis of the steroidogenic activity of the tumor: a case report.
abstract: An adrenocortical cancer was detected by a CT scan in a 37-year-old woman, which did not have an excessive secretion of steroids or catecholamines. The tumor was enhanced inhomogeneously by the bolus injection of contrast medium, and magnetic resonance imaging (MRI) showed that the tumor was hypointense compared to the liver on a T1-weighted image and was diffusely hyperintense on a T2-weighted image. Histologically, the tumor consisted predominantly of compact cells with marked cellular and nuclear pleomorphism, but no capsular or vascular invasion were observed. An analysis of the steroidogenic activity of the tumor revealed that the activity of mitochondrial P450c11beta was extremely reduced in the tumor.
authors.affiliation: Department of Urology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Morioka
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.forename: T X
authors.initials: TX
authors.lastname: Jin
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Furihata
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D000328:Adult; D002277:Carcinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D002395:Catecholamines / Q000097:blood / Q000378:metabolism / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008279:Magnetic Resonance Imaging; D013256:Steroids / Q000097:blood* / Q000652:urine*; D014057:Tomography, X-Ray Computed
chemical_list: D002395:Catecholamines; D013256:Steroids