title: Negative influence of RasG on chemoattractant-induced ERK2 phosphorylation in Dictyostelium.
abstract: The Dictyostelium ERK2 protein is transiently activated when cells are treated with the chemotactic agents cAMP or folic acid. Activating phosphorylation is markedly inhibited in strains overexpressing the constitutively activated RasG protein. This is in marked contrast to mammalian cells where the highly related mitogen-activated protein kinases (MAPKs) are stimulated by Ras activation.
authors.affiliation: Biochemistry Department, Oxford University, UK.
authors.forename: C
authors.initials: C
authors.lastname: Kosaka
authors.forename: M
authors.initials: M
authors.lastname: Khosla
authors.forename: G
authors.initials: G
authors.lastname: Weeks
authors.forename: C
authors.initials: C
authors.lastname: Pears
mesh_terms: D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D002630:Chemotactic Factors / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology*; D004023:Dictyostelium / Q000187:drug effects / Q000378:metabolism*; D005492:Folic Acid / Q000494:pharmacology*; D007700:Kinetics; D019950:Mitogen-Activated Protein Kinase 1; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D017354:Point Mutation; D012333:RNA, Messenger / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D002630:Chemotactic Factors; D012333:RNA, Messenger; D011994:Recombinant Proteins; D019000:Phosphotyrosine; D005492:Folic Acid; D000242:Cyclic AMP; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019950:Mitogen-Activated Protein Kinase 1