title: Effects of aerobic training in patients with mitochondrial myopathies.
abstract: We studied the physiologic adaptation of patients with mitochondrial myopathies to aerobic training. Ten patients underwent individually supervised, moderate-intensity aerobic training on a treadmill for 8 weeks. Biochemical and functional measures improved with training. Estimated aerobic capacity increased by 30%. Blood lactate concentrations at rest and after exercise decreased by 30%. Muscle phosphorus magnetic resonance spectroscopy measurements of adenosine diphosphate recovery after exercise improved by more than 60%. Fatigue and tolerance to daily activities also improved. Although the improvement in exercise tolerance may be due in part to reversal of the effects of secondary deconditioning, this uncontrolled clinical trial suggests that aerobic training can benefit patients with mitochondrial myopathies.
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, Quebec, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Taivassalo
authors.forename: N
authors.initials: N
authors.lastname: De Stefano
authors.forename: Z
authors.initials: Z
authors.lastname: Argov
authors.forename: P M
authors.initials: PM
authors.lastname: Matthews
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Genge
authors.forename: G
authors.initials: G
authors.lastname: Karpati
authors.forename: D L
authors.initials: DL
authors.lastname: Arnold
mesh_terms: D000203:Activities of Daily Living; D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D003402:Creatine Kinase / Q000097:blood; D004272:DNA, Mitochondrial / Q000235:genetics; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005081:Exercise Therapy; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D017240:Mitochondrial Myopathies / Q000235:genetics / Q000534:rehabilitation / Q000628:therapy*; D009154:Mutation
chemical_list: D004272:DNA, Mitochondrial; D019344:Lactic Acid; D003402:Creatine Kinase