[Diversity of P 450: biology and application of diversozyme].
Cytochrome P 450s (P 450s) are a gene superfamily of heme enzymes involved in xeno-or endo-biotic metabolisms. They have approximately 500 isozymes via evolution, immense diversity in their functions and a broad range of substrate specificities. Thus, they are called diversozymes and their versatility is understood as a mechanism for living via detoxification of toxicants. However, some of the huge human-made chemicals are bioactivated by P 450s. To explain diversity of P 450s, further studies regarding relations between crystal structures and functions of P 450s are required. P 450s can be applied for exposure-biomarkers of environmental pollution, screening of drug metabolism and remedy for pollutants.
Yang
M
M
Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
D000818:Animals; D005075:Biological Evolution; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D014644:Genetic Variation; D006801:Humans; D008658:Inactivation, Metabolic; D007527:Isoenzymes / Q000378:metabolism
D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System