In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent.
In vitro and in vivo antidermatophyte activities of NND-502, a new imidazole antimycotic agent, were compared with those of two existing antifungal agents, lanoconazole and terbinafine. NND-502 exhibited strong in vitro antifungal activity against Trichophyton spp.; its MIC was 1 to 4 times lower than that of lanoconazole or terbinafine. In an in vivo study with a guinea pig model of tinea pedis, 7-day topical treatment with a 0.5% solution of NND-502 (dissolved in polyethylene glycol 400) was more effective than that with a 0.5% solution of either lanoconazole or terbinafine for eradicating fungi from the infected feet. When the duration of treatment was shortened to 3 days, a topical 1% solution of NND-502 achieved a complete mycological cure, while topical 1% solutions of lanoconazole and terbinafine did not.
Niwano
Y
Y
Research Center, Nihon Nohyaku Co., Ltd., Kawachinagano, Osaka, Japan. mntoxlab@os.luice.or.jp
Kuzuhara
N
N
Kodama
H
H
Yoshida
M
M
Miyazaki
T
T
Yamaguchi
H
H
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003883:Arthrodermataceae / Q000187:drug effects*; D003881:Dermatomycoses / Q000188:drug therapy* / Q000382:microbiology; D006168:Guinea Pigs; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D014008:Tinea Pedis / Q000188:drug therapy / Q000382:microbiology
D000935:Antifungal Agents; D007093:Imidazoles; C112528:luliconazole