[Increased occurrence of esophageal hypermotility disorders in patients with arterial hypertension].
OBJECTIVE
It has been noted in previous manometric examinations of the oesophagus in patients with chest pain that abnormal motility was often associated with arterial hypertension. A systematic study of this relationship was therefore undertaken.


METHODS
In 40 patients with chest pain (18 women and 22 men, mean age 54.7 [24-70] years) and in 20 healthy volunteers (12 men, 8 women, mean age 50.8 [22-63] years) standardized oesophageal manometry and arterial blood pressure monitoring were performed over 24 hours. Coronary heart disease and gastrointestinal lesions had been excluded by angiography and endoscopy, respectively.


RESULTS
20 patients (group H) had hypertension (median 24-hour blood pressure > 135/85 mmHg), while 20 patients (group N) and the normal controls (group K) were normotensive. Oesophageal manometry data differed significantly between the three groups regarding distal pressure amplitude (in hPa [hectopascals]; group H: 62 hPa*,**, group N 44 hPa* and group K 36 hPa**; [*P < 0.0005]) and the proportion of simultaneous contractions (group H 23%, group N 22%**, group K 10%***; ***P < 0.001). The hypertensive patients had significantly more frequent motility abnormalities than normal controls (13/20 vs 4/20, P < 0.001); while normotensive patients had more frequent episodes of abnormal propulsion in the oesophagus (proportion of propulsive contractions in group H: 53%, in N: 44%, in K: 59%; P < 0.01).


CONCLUSIONS
Oesophageal motility differed significantly in patients with chest pain from that in healthy controls. Patients with chest pain and hypertension more frequently had oesophageal hypermotility. This suggests a generalized abnormality of smooth muscle.
Adamek
R J
RJ
Medizinische Klinik, Ruhr-Universität, St. Josef-Hospital, Bochum. Romuald.J.Adamek@ruhr-uni-bochum.de
Bock
S
S
Szymanski
C
C
Hagemann
D
D
Pfaffenbach
B
B
D000328:Adult; D000368:Aged; D018660:Blood Pressure Monitoring, Ambulatory; D002637:Chest Pain / Q000209:etiology*; D015154:Esophageal Motility Disorders / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011673:Pulsatile Flow