title: Effect of infusion of hypertonic saline solution of conscious heifers with hypoxemia caused by endotoxin infusion.
abstract: OBJECTIVE
  To compare effects of i.v. infusion of a small volume (5 ml/kg of body weight) of hypertonic saline (7.2% NaCl) solution (HSS) and i.v. infusion of an equivalent volume of isotonic saline (0.9% NaCl) solution (ISS) on arterial blood gases in conscious heifers with hypoxemia caused by endotoxin infusion.
  
  
  METHODS
  9 Holstein heifers.
  
  
  METHODS
  All heifers received 2.0 microg of endotoxin/kg, i.v., during a 5-minute period. Twenty-five minutes after endotoxin infusion, 3 heifers received ISS, 3 received HSS, and the remaining 3 did not receive fluids (control). Heifers were monitored for 150 minutes after initiation of fluid replacement. Arterial blood gases, blood pressure, and serum electrolyte concentrations were measured.
  
  
  RESULTS
  Endotoxin administration had a profound effect on pulmonary function, causing severe hypoxemia accompanied by a significant decrease in the partial pressure of oxygen (PaO2) and a significant increase in the arterial-alveolar O2 gradient (P[A-a]O2). Cattle in the HSS group had progressive and significant increases in PaO2 and O2 saturation, compared with the other groups. The P(A-a)O2 values for the control and ISS groups were slightly decreased until 150 minutes after initiation of fluid replacement; however, HSS infusion induced a progressive and significant decrease in P(A-a)O2 for the remainder of the experimental period.
  
  
  CONCLUSIONS
  Rapid infusion of HSS can successfully resuscitate conscious cattle with induced pulmonary dysfunction. Infusion of HSS may be beneficial for initial resuscitation of cattle with naturally developing bovine respiratory disease complex.
authors.affiliation: Central Research Laboratories, Nippon Zenyaku Kogyo Co Ltd, Koriyama City, Fukushima Pre, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Ajito
authors.forename: S
authors.initials: S
authors.lastname: Iwabuchi
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002417:Cattle; D003243:Consciousness; D004573:Electrolytes / Q000097:blood; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005260:Female; D000860:Hypoxia / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D007262:Infusions, Intravenous; D009997:Osmotic Pressure; D010100:Oxygen / Q000097:blood; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004573:Electrolytes; D004731:Endotoxins; D012462:Saline Solution, Hypertonic; D010100:Oxygen