Bacterial endotoxins and nonspecific resistance.
The stress situations, including medical intervention (e.g. operations, antitumor drugs, irradiation, etc.) decrease the nonspecific resistance of the body. In these situations patients people have greater chance to get an opportunistic infection than healthy ones. The restoration or elevation of the activity of immune system in injured patients is a very important task of medicine. Minute amounts of bacterial endotoxin (LPS)--given parenterally--can elevate the nonspecific resistance. Unfortunately this beneficial influence is associated with noxious properties. Irradiation (60 Co-gamma; 150 kGy) is a good technique for the detoxification of LPS. The radiodetoxified endotoxin (RD-LPS) preparation (so-called TOLERIN) is less toxic but its beneficial properties is preserved. On the basis of animal experiments and clinical trials TOLERIN could be a suitable preparation for regeneration of the lymphoreticular-immune system and elevation of nonspecific resistance.
Bertók
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Frédéric Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001427:Bacterial Toxins / Q000276:immunology*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D004285:Dogs; D004731:Endotoxins / Q000494:pharmacology; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D016060:Sorption Detoxification
D001427:Bacterial Toxins; D004731:Endotoxins; C010797:tolerin