Oxyfedrine in myocardial stunning.
Effect of oxyfedrine (OXF)(1 mg/kg) administered just before reperfusion (post-treatment) was investigated in a canine model of myocardial stunning. In the saline-treated animals, myocardial stunning was evidenced by fall in MAP, decrease in LV peak (+) dP/dt, rise in LVEDP and incomplete regeneration of myocardial ATP, after reperfusion. OXF was found to be effective in preventing the haemodynamic and metabolic changes associated with myocardial stunning.
Maulik
S K
SK
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
Seth
S D
SD
Maulik
M
M
Manchanda
S C
SC
D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D017682:Myocardial Stunning / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism; D010099:Oxyfedrine / Q000627:therapeutic use*
D002316:Cardiotonic Agents; D010099:Oxyfedrine