title: Mitochondrial abnormalities in selenium-deficient myopathy.
abstract: We report a man who developed selenium-deficient myopathy during long-term parenteral nutrition. Muscle biopsy showed marked mitochondrial depletion in the deep sarcoplasm and enlarged mitochondria at the periphery mainly in type 2 fibers. Muscle weakness improved gradually after the second course of selenium supplementation. The peculiar mitochondrial abnormalities in muscle fibers appear to play a key role in the pathogenesis of selenium-deficient myopathy.
authors.affiliation: Department of Medicine and Geriatrics, Kochi Medical School, Nankoku-city, Kochi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Osaki
authors.forename: I
authors.initials: I
authors.lastname: Nishino
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Matsubayashi
authors.forename: K
authors.initials: K
authors.lastname: Tsuda
authors.forename: Y I
authors.initials: YI
authors.lastname: Yokoyama
authors.forename: M
authors.initials: M
authors.lastname: Morita
authors.forename: S
authors.initials: S
authors.lastname: Onishi
authors.forename: Y I
authors.initials: YI
authors.lastname: Goto
authors.forename: I
authors.initials: I
authors.lastname: Nonaka
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000473:pathology*; D017240:Mitochondrial Myopathies / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D018908:Muscle Weakness / Q000188:drug therapy / Q000503:physiopathology; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D010288:Parenteral Nutrition / Q000009:adverse effects; D012643:Selenium / Q000172:deficiency* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D012643:Selenium