title: Working and strategic memory deficits in schizophrenia.
abstract: Working memory and its contribution to performance on strategic memory tests in schizophrenia were studied. Patients (n = 18) and control participants (n = 15), all men, received tests of immediate memory (forward digit span), working memory (listening, computation, and backward digit span), and long-term strategic (free recall, temporal order, and self-ordered pointing) and nonstrategic (recognition) memory. Schizophrenia patients performed worse on all tests. Education, verbal intelligence, and immediate memory capacity did not account for deficits in working memory in schizophrenia patients. Reduced working memory capacity accounted for group differences in strategic memory but not in recognition memory. Working memory impairment may be central to the profile of impaired cognitive performance in schizophrenia and is consistent with hypothesized frontal lobe dysfunction associated with this disease. Additional medial-temporal dysfunction may account for the recognition memory deficit.
authors.affiliation: Department of Psychology, Stanford University, USA. mstone@mail.arc.nasa.gov
authors.forename: M
authors.initials: M
authors.lastname: Stone
authors.forename: J D
authors.initials: JD
authors.lastname: Gabrieli
authors.forename: G T
authors.initials: GT
authors.lastname: Stebbins
authors.forename: E V
authors.initials: EV
authors.lastname: Sullivan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000503:physiopathology; D008570:Memory, Short-Term / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012691:Serial Learning / Q000502:physiology; D014836:Volition / Q000502:physiology