title: Antioxidant vitamin levels in plasma and low density lipoprotein of obese girls.
abstract: To investigate the antioxidant status of obese children, we analyzed beta-carotene and alpha-tocopherol levels in plasma and low density lipoprotein (LDL). We also analyzed the fatty acid composition of LDL as a substrate for oxidative stress. The plasma beta-carotene and alpha-tocopherol levels were relatively lower in obese girls than in normal controls. However, the plasma alpha-tocopherol/lipids ratio was significantly lower in obese girls than in normal controls. Both LDL beta-carotene and LDL alpha-tocopherol levels were significantly lower in obese girls than in normal controls, although no obvious differences were observed in plasma levels. In obese girls LDL contained more polyunsaturated fatty acid (PUFA) compared with normal controls. When the peroxidizability index (PI) was calculated to estimate the susceptibility of lipids to oxidative stress, obese girls had significantly higher PI values than normal controls. Both the LDL beta-carotene/PI ratio and the LDL alpha-tocopherol/PI ratio were significantly lower in obese girls than in normal controls. These results indicate the increased susceptibility of LDL to oxidative stress in obese girls which may promote atherosclerosis later in life.
authors.affiliation: Department of Pediatrics, Osaka Medical College, Takatsuki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kuno
authors.forename: M
authors.initials: M
authors.lastname: Hozumi
authors.forename: T
authors.initials: T
authors.lastname: Morinobu
authors.forename: T
authors.initials: T
authors.lastname: Murata
authors.forename: Z
authors.initials: Z
authors.lastname: Mingci
authors.forename: H
authors.initials: H
authors.lastname: Tamai
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D002648:Child; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood*; D009765:Obesity / Q000097:blood*; D018384:Oxidative Stress; D014810:Vitamin E / Q000097:blood; D014815:Vitamins / Q000097:blood*; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D008077:Lipoproteins, LDL; D014815:Vitamins; D019207:beta Carotene; D014810:Vitamin E