[Vaccination against cancer soon a therapeutic possibility. B-cell tumors, colonic cancer and melanoma may be suitable for this treatment].
The theoretical basis of cancer vaccination having been well established during the past two decades, the translation of this knowledge into clinically applicable immunisation procedures is now an urgent need. Numerous antigenic preparations are available that are capable of inducing specific anti-tumour immunity which can be augmented by appropriate cytokines. Promising tumour vaccination results have been obtained in B-cell malignancies, colorectal carcinoma, and melanoma; tumour regression has been noted in myeloma, non-Hodgkin lymphoma, colorectal carcinoma, and melanoma patients, and significantly prolonged disease-freed survival in non-Hodgkin lymphoma and colorectal carcinoma patients. The presence of only minimal residual disease would seem to be a clinical prerequisite for tumour vaccination.
Mellstedt
H
H
Uppsala universitet.
Fagerberg
J
J
Osterborg
A
A
D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000600:supply & distribution*; D003110:Colonic Neoplasms / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D015448:Leukemia, B-Cell / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000517:prevention & control*; D008545:Melanoma / Q000276:immunology / Q000517:prevention & control*
D000888:Antibodies, Anti-Idiotypic; D019496:Cancer Vaccines