title: Pseudoepitheliomatous hyperplasia versus squamous cell carcinoma of the external auditory canal.
abstract: Four case reports are presented to demonstrate the clinical and histopathologic similarity of pseudoepitheliomatous hyperplasia (PH) to squamous cell carcinoma (SCC) in the external auditory canal (EAC). In all four cases the original report of SCC on a biopsy specimen of an EAC lesion was corrected on review to PH. In one patient conservative management resulted in resolution of the EAC lesion. A second patient underwent radiation therapy and partial temporal bone resection with no SCC found in the surgical specimen. A third patient's ear canal had healed with conservative treatment and repeated biopsy revealed no malignancy. After a 6-year symptom-free interval, she developed invasive SCC with bone involvement that required surgery and radiation treatment. A fourth patient underwent a sleeve resection of the skin of the EAC that proved to be PH, and no evidence of SCC was found. A thoughtful clinical history, careful physical examination, response to conservative treatment, and close communication with the pathologist should be exercised in the evaluation of EAC lesions.
authors.affiliation: Department of Otolaryngology, University of Iowa, Iowa City, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Gacek
authors.forename: R R
authors.initials: RR
authors.lastname: Gacek
authors.forename: B
authors.initials: B
authors.lastname: Gantz
authors.forename: M
authors.initials: M
authors.lastname: McKenna
authors.forename: M
authors.initials: M
authors.lastname: Goodman
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D003142:Communication; D003937:Diagnosis, Differential; D004424:Ear Canal / Q000473:pathology* / Q000528:radiation effects / Q000601:surgery; D004428:Ear Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D004848:Epithelium / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia; D007400:Interprofessional Relations; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010808:Physical Examination; D013701:Temporal Bone / Q000601:surgery