title: Urinary excretion of aquaporin-2 in term and preterm infants.
abstract: Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel of the renal collecting duct and is excreted in human urine. We measured the urinary excretion of AQP-2 by radioimmunoassay in 14 term and 12 preterm infants aged 1 month. Excretion of AQP-2 was low compared with adults, and correlated significantly with urine osmolality in preterm infants. Our results demonstrate that AQP-2 water channels are expressed in the renal collecting duct of both term and preterm infants.
authors.affiliation: Department of Pediatrics, Fukui Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsukahara
authors.forename: I
authors.initials: I
authors.lastname: Hata
authors.forename: K
authors.initials: K
authors.lastname: Sekine
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: K
authors.initials: K
authors.lastname: Hata
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
authors.forename: M
authors.initials: M
authors.lastname: Mayumi
mesh_terms: D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D001127:Arginine Vasopressin / Q000652:urine; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000652:urine*; D007234:Infant, Premature / Q000652:urine*; D007473:Ion Channels / Q000652:urine*; D008297:Male; D009994:Osmolar Concentration; D011863:Radioimmunoassay; D012016:Reference Values; D014556:Urine
chemical_list: C496023:AQP2 protein, human; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D007473:Ion Channels; D001127:Arginine Vasopressin