G-protein signaling: fine-tuning signaling kinetics.
Mammalian 'regulators of G protein signaling' (RGS proteins) help shut off G-protein-mediated signaling by GTPase activation. But new evidence shows that RGS proteins can also speed up the activation of signaling. The combined effect is a change in signaling kinetics without a decrease in signaling intensity.
Zerangue
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Howard Hughes Medical Institute, Department of Physiology, University of California San Francisco, California 94143, USA. zerangue@phy.ucsf.edu
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D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D015398:Signal Transduction / Q000502:physiology*
D007473:Ion Channels; D019204:GTP-Binding Proteins