title: Cigarette smoking and cervical dysplasia among non-Hispanic black women.
abstract: This is the first case-control study to determine whether smoking is associated with cervical dysplasia, after adjustment for human papillomavirus (HPV) infection, among a group of non-Hispanic black women. Subjects were interviewed and asked questions about smoking and other risk factors for cervical cancer. HPV infection was determined by hybrid capture. Thirty-two women with histologically confirmed incident dysplasia and 113 control women with normal cytologic smears were enrolled; all women were HIV negative. Smoking was more strongly associated with dysplasia among women with high-grade lesions than among all case women combined. After adjustment, women with high-grade lesions were roughly four times more likely to be ever (odds ratio [OR]: 3.8; 95% confidence interval [CI]: 0.76-18.4) or current (OR: 4.3; 95% CI: 0.83-21.9) smokers, compared with control women. Larger studies among black women that control for HPV infection are needed to confirm these findings and to explore associations among black women with low-grade lesions.
authors.affiliation: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Kanetsky
authors.forename: M D
authors.initials: MD
authors.lastname: Gammon
authors.forename: J
authors.initials: J
authors.lastname: Mandelblatt
authors.forename: Z F
authors.initials: ZF
authors.lastname: Zhang
authors.forename: E
authors.initials: E
authors.lastname: Ramsey
authors.forename: T C
authors.initials: TC
authors.lastname: Wright
authors.forename: L
authors.initials: L
authors.lastname: Thomas
authors.forename: S
authors.initials: S
authors.lastname: Matseoane
authors.forename: N
authors.initials: N
authors.lastname: Lazaro
authors.forename: H T
authors.initials: HT
authors.lastname: Felton
authors.forename: R K
authors.initials: RK
authors.lastname: Sachdev
authors.forename: R M
authors.initials: RM
authors.lastname: Richart
authors.forename: J P
authors.initials: JP
authors.lastname: Curtin
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009518:New York / Q000453:epidemiology; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000209:etiology*