title: European Lyme borreliosis clinical spectrum.
abstract: At a series of meetings, involving 27 clinicians from 11 countries, case definitions for the diagnosis of Lyme borreliosis in Europe were agreed and are presented here, with appropriate serological criteria, as a diagnostic guide. In a separate study questionnaires directed to clinicians were used to collect information on clinical aspects and risk factors of Lyme borreliosis. Data on the number of Lyme borreliosis patients seen by physicians indicated a low prevalence of the disease in western Europe and a relatively high prevalence in eastern Europe. The most commonly encountered symptom was erythema migrans, followed by neurological manifestations. Cardiac problems were rare. Tick bite was strongly associated with Lyme borreliosis, but the only other significantly associated risk factor was the pastime of gardening.
authors.affiliation: Dipartimento di Medicina Interna, Universita degli Studi de Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cimmino
authors.forename: M
authors.initials: M
authors.lastname: Granström
authors.forename: J S
authors.initials: JS
authors.lastname: Gray
authors.forename: E C
authors.initials: EC
authors.lastname: Guy
authors.forename: S
authors.initials: S
authors.lastname: O'Connell
authors.forename: G
authors.initials: G
authors.lastname: Stanek
mesh_terms: D003951:Diagnostic Errors; D005062:European Union; D006801:Humans; D008193:Lyme Disease / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology; D009422:Nervous System Diseases; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D012871:Skin Diseases