title: Emergency vaccination of pigs against foot-and-mouth disease: protection against disease and reduction in contact transmission.
abstract: The protective ability of two novel oil-based FMD vaccines in pigs was examined. Both vaccine formulations were shown to protect pigs against airborne challenge with homologous FMDV within four days of vaccination, but not at two and three days post-vaccination. Protection was associated with the induction of variable and low titre serum antibody responses. A transmission study showed that protective immunisation resulted in reduced virus excretion. Vaccination at seven days, but not at four days, prior to challenge prevented contact transmission of FMD. The two formulations tested in this study have the favourable characteristics of low viscosity, low reactivity and high potency emergency FMD vaccines for use in strategic vaccination campaigns to assist the control of outbreaks of FMD.
authors.affiliation: Institute for Animal Health, Pirbright Laboratory, Surrey, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Salt
authors.forename: P V
authors.initials: PV
authors.lastname: Barnett
authors.forename: P
authors.initials: P
authors.lastname: Dani
authors.forename: L
authors.initials: L
authors.lastname: Williams
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D005537:Aphthovirus / Q000276:immunology*; D004655:Emulsions; D005536:Foot-and-Mouth Disease / Q000517:prevention & control* / Q000635:transmission*; D007115:Immunization Schedule; D009821:Oils; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control* / Q000635:transmission*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D014867:Water
chemical_list: D000276:Adjuvants, Immunologic; D000956:Antigens, Viral; D004655:Emulsions; D009821:Oils; D014765:Viral Vaccines; D014867:Water