Defining the maximum tolerated dose: investigator, academic, industry and regulatory perspectives.
Cutler
N R
NR
Tufts University School of Medicine, Boston, Massachusetts, USA.
Sramek
J J
JJ
Greenblatt
D J
DJ
Chaikin
P
P
Ford
N
N
Lesko
L J
LJ
Davis
B
B
Williams
R L
RL
D000818:Animals; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004345:Drug Industry; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D012107:Research Design; D014481:United States; D014486:United States Food and Drug Administration