Downmodulation of HLA class I expression by dexamethasone in MCF-7 cell line.
Several reports have shown the importance of MHC class I antigens in enabling the host to regulate tumour growth in vivo. Glucocorticoid hormones have strong immunosuppressive effects and are known to be regulators of gene transcription. In this report the expression of Major Histocompatibility Complex (MHC) class I antigens in six breast carcinoma cell lines have been studied before and after treatment with the synthetic glucocorticoid dexamethasone. Hence, HLA class I expression in the MCF-7 cell line was down-regulated in the presence of dexamethasone. This down-modulation of expression appeared to be mediated by transcriptional mechanisms, as revealed by HLA-class I mRNA levels.
Rodríguez
F
F
Servicio de Análisis Clínicos de los hospitales General Básico, Motril/Granada, Spain.
Redondo
M
M
Hortas-Nieto
M L
ML
Téllez-Santana
T
T
Pérez-Valero
V
V
Ruiz-Cabello
F
F
D001943:Breast Neoplasms; D003907:Dexamethasone / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects* / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D005805:Genes, MHC Class I / Q000187:drug effects; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis* / Q000187:drug effects; D006801:Humans; D014407:Tumor Cells, Cultured
D015395:Histocompatibility Antigens Class I; D003907:Dexamethasone