[Synthesis of phthalocyanine conjugates with monoclonal antibodies in AOT/n-octane reversed micelles and in water-organic solvent mixtures].
Conjugates of cobalt and aluminum phthalocyanines with monoclonal antibodies were synthesized using an AOT/n-octane reversed micellar system or water-organic mixtures with a low content of organic solvent as media. The effect of the degree of hydration of the micelles and the concentration of phthalocyanines on the composition of conjugates was studied. The immune activity of the resulting conjugates in comparison to that of native antibodies was evaluated. The catalytic activity of free cobalt phthalocyanines and their antibody conjugates was studied in the reaction of ascorbic acid oxidation.
Matveeva
E G
EG
Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia.
Meerovich
I G
IG
Savitskiĭ
A P
AP
D000535:Aluminum / Q000737:chemistry; D000911:Antibodies, Monoclonal / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry; D004143:Dioctyl Sulfosuccinic Acid / Q000737:chemistry; D018796:Immunoconjugates / Q000737:chemistry* / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry*; D008823:Micelles; D009795:Octanes / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D010047:Ovalbumin; D010084:Oxidation-Reduction; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
D000911:Antibodies, Monoclonal; D018796:Immunoconjugates; D007211:Indoles; D008823:Micelles; D009795:Octanes; D009942:Organometallic Compounds; D012997:Solvents; D014867:Water; D004143:Dioctyl Sulfosuccinic Acid; C063633:cobalt phthalocyanine; D003035:Cobalt; D010047:Ovalbumin; D000535:Aluminum; D001205:Ascorbic Acid; C026728:octane