Compensatory excretion of prostacyclin and thromboxane metabolites in obstructive sleep apnea syndrome.
Since obstructive sleep apnea syndrome (OSAS) is often linked with systemic hypertension, we sought to clarify the characteristics of prostanoid metabolism in OSAS. In 7 OSAS patients (apnea-hypopnea index, 51.0 +/- 23.4) and 7 non-snorers as control, nocturnal urine was sampled and analyzed for stable metabolites of prostacyclin (PGI2) and thromboxane A2 (TxA2), [6-keto-PGF1alpha and thromboxane B2 (TxB2)]. The ratio of 6-keto-PGF1alpha to TxB2 was significantly higher in OSAS (2.97 +/- 1.52) than in control (1.38 +/- 0.38). Successful treatment with nasal continuous positive airway pressure (8.3 +/- 1.5 cmH2O) for 3 days caused a significant decrease in mean blood pressure in OSAS. Moreover, the 6-keto-PGF1alpha to TxB2 ratio also significantly decreased to 1.74 +/- 0.58, a level which may not significantly different from control. These results suggest that the production ratio of PGI2 to TxA2 is shifted toward vasodilatation in untreated OSAS. We conclude that the production of prostanoids plays a role in compensating for the systemic hypertension in OSAS.
Kimura
H
H
Department of Chest Medicine, Chiba University School of Medicine.
Niijima
M
M
Abe
Y
Y
Edo
H
H
Sakabe
H
H
Kojima
A
A
Hasako
K
K
Masuyama
S
S
Tatsumi
K
K
Kuriyama
T
T
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine*; D000328:Adult; D001794:Blood Pressure; D016022:Case-Control Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000503:physiopathology / Q000652:urine*; D013929:Thromboxane B2 / Q000652:urine*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D010100:Oxygen