Stroke in a neonate heterozygous for factor V Leiden.
Activated protein C resistance is the most common hereditary coagulation abnormality and is caused by the factor V Leiden mutation. A newborn who developed seizures within hours after delivery and was found to have a bihemispheric stroke is described. This patient, determined to be heterozygous for factor V Leiden, is the first reported case of neonatal stroke associated with this common mutation.
Varelas
P N
PN
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Sleight
B J
BJ
Rinder
H M
HM
Sze
G
G
Ment
L R
LR
D002561:Cerebrovascular Disorders / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D014057:Tomography, X-Ray Computed
C095381:factor V Leiden; D005165:Factor V