Synthesis of some new pyrimidine derivatives as potential anticancer and anti-HIV agent.
Several 2,4-diaminopyrimidines have been synthesized and tested for their anticancer and anti-HIV activities. Out of these, eight compounds displayed significant activity against leukemia, melanoma, non-small cell and CNS cancer. Two compounds were active against leukemia P388. One compound has been found to be moderately active as compared to AZT.
Debi
M
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Department of Chemical Technology, Calcutta University, India.
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D011743:Pyrimidines