The effect of azadirachtin on fresh isolates of Trypanosoma cruzi in different species of triatomines.
The effect of azadirachtin was investigated using three different fresh isolates of Trypanosoma cruzi and five different triatomine species which were infected as third-instar larvae. The two T. cruzi strains which originated from sylvatic Triatoma vitticeps showed a high prevalence after the molt to the fifth instar in Panstrongylus megistus and Rhodnius neglectus and a low prevalence in Triatoma infestans and Rhodnius robustus. The third T. cruzi strain originating from a patient in Piaui showed a high prevalence in P. megistus, R. neglectus and T. infestans and a low prevalence in Triatoma sordida. Feeding the infected fifth instars with azadirachtin-supplemented blood (1 microg/ml) resulted 20 days later in some parasite/vector combinations in an increase, in others a decrease or an unchanged number of T. cruzi in comparison to bugs fed with unsupplemented blood.
Kollien
A H
AH
Department of Special Zoology, Ruhr University, Bochum, Germany. Guenter.A.Schaub@rz.ruhr-uni-bochum.de
Gonçalves
T C
TC
De Azambuja
P
P
Garcia
E S
ES
Schaub
G A
GA
D000818:Animals; D006790:Host-Parasite Interactions; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology*; D036701:Limonins; D051379:Mice; D013045:Species Specificity; D014224:Triatoma / Q000469:parasitology*; D014315:Triterpenes / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
D036701:Limonins; D014315:Triterpenes; D014344:Trypanocidal Agents; C010329:azadirachtin