Action of neurotransmitters: acetylcholine, serotonin, and adrenaline in an experimental arterial thrombosis induced by oxygen free radicals.
It is well known that high stress and particularly an enhancement of plasma catecholamines and myocardial infarction have a close relation. In addition, adrenaline is presented as a prothrombogenic agent in vivo. The role of the other agents such as serotonin or acetylcholine, in the development of arterial thrombosis is somewhat uncertain, although, the role of each of them is often considered at the level of vascular regulation only. Therefore, the present study was designed to investigate the effects of three neurotransmitters on experimental arterial thrombosis model induced by generation of free radicals. The results demonstrate that intravenously injection of adrenaline or serotonin (1 ng/kg) stimulated arterial thrombosis formation, whereas injection of high dose of acetylcholine (5 mg/kg) slackened the thrombosis formation.
Belougne-Malfatti
E
E
Laboratoire d'Hématologie, Faculté de Pharmacie, Université de Bordeaux II, France.
Aguejouf
O
O
Doutremepuich
F
F
Doutremepuich
C
C
D000109:Acetylcholine; D000818:Animals; D004195:Disease Models, Animal; D004837:Epinephrine; D008297:Male; D018377:Neurotransmitter Agents; D010777:Photochemistry; D051381:Rats; D017208:Rats, Wistar; D012395:Rose Bengal; D012701:Serotonin; D013152:Splanchnic Circulation; D013481:Superoxides; D013927:Thrombosis / Q000139:chemically induced*
D018377:Neurotransmitter Agents; D013481:Superoxides; D012395:Rose Bengal; D012701:Serotonin; D000109:Acetylcholine; D004837:Epinephrine