An unusual dienone-phenol rearrangement product formed during the synthesis of mometasone furoate (Sch 32088).
The structure of an unusual dienone-phenol rearrangement product 4 obtained during the synthesis of mometasone furoate (Sch 32088) was assigned on the basis of NMR and x-ray crystallographic data. The mechanism of formation is discussed.
Draper
R W
RW
Chemical Process Development Department, Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
Puar
M S
MS
Vater
E J
EJ
McPhail
A T
AT
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D000068656:Mometasone Furoate; D010636:Phenols / Q000737:chemistry*; D011244:Pregnadienediols / Q000138:chemical synthesis* / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D010636:Phenols; D011244:Pregnadienediols; D000068656:Mometasone Furoate