Mechanisms of cysteine S-conjugate beta-lyases.
Mercapturic acids are conjugates of S-(N-acetyl)-L-cysteine formed during the detoxification of xenobiotics and during the metabolism of such endogenous agents as estrogens and leukotrienes. Many mercaturates are formed from the corresponding glutathione S-conjugates. This chapter focuses on (a) the discovery of the cysteine S-conjugate beta-lyases; (b) the involvement of pyridoxal-5-phosphate; (c) the influence of the electron-withdrawing properties of the group attached to the sulfur atom; and (d) the potential of cysteine S-conjugates as pro-drugs.
Cooper
A J
AJ
Department of Biochemistry, Cornell University Medical College, New York 10021, USA.
D000818:Animals; D001419:Bacteria / Q000201:enzymology; D013437:Carbon-Sulfur Lyases / Q000378:metabolism*; D003545:Cysteine / Q000031:analogs & derivatives*; D005658:Fungi / Q000201:enzymology; D006801:Humans; D008658:Inactivation, Metabolic; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051381:Rats; D015262:Xenobiotics / Q000633:toxicity
D015262:Xenobiotics; D013437:Carbon-Sulfur Lyases; C108902:cysteine-S-conjugate beta-lyase; D003545:Cysteine