A prospective clinical trial comparing metrizamide and iohexol for equine myelography.
A prospective clinical trial comparing adverse postmyelographic effects and myelographic quality of metrizamide and iohexol was conducted. Using a predetermined, randomized assignment, 24 horses exhibiting neurologic signs were administered either metrizamide (180 mgl/ml) or iohexol (180 mgl/ml) via cerebellomedullary puncture. Each horse was evaluated postmyelographically for adverse effects. Myelographic quality was assessed by a numerical scoring method. Adverse effects were observed more frequently with metrizamide (21) compared with iohexol (6) myelography (p < 0.05). Seizures, intensification of preexisting neurologic signs and prolonged anesthetic recovery were the most common complications after myelography. There was no difference in myelographic quality (p > 0.05). We conclude that iohexol is safer than metrizamide for equine myelography and that quality myelograms can be obtained with either contrast medium.
Widmer
W R
WR
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA.
Blevins
W E
WE
Jakovljevic
S
S
Levy
M
M
Teclaw
R F
RF
Han
C M
CM
Hurd
C D
CD
D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation / Q000662:veterinary; D000771:Anesthesia, Intravenous / Q000662:veterinary; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000662:veterinary; D006734:Horse Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging*; D006736:Horses / Q000145:classification; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008793:Metrizamide / Q000008:administration & dosage / Q000009:adverse effects; D009192:Myelography / Q000379:methods / Q000662:veterinary*; D011446:Prospective Studies; D011677:Punctures / Q000662:veterinary; D011856:Radiographic Image Enhancement; D011897:Random Allocation; D012449:Safety; D012640:Seizures / Q000139:chemically induced / Q000662:veterinary; D013118:Spinal Cord Diseases / Q000000981:diagnostic imaging / Q000662:veterinary
D003287:Contrast Media; D007472:Iohexol; D008793:Metrizamide