title: Progressive pan-colonic fibrosis secondary to oral administration of pancreatic enzymes.
abstract: Most patients with cystic fibrosis require oral administration of pancreatic enzymes to treat pancreatic insufficiency. Recent use of higher-strength enzyme preparations in large doses has been found to be associated with fibrotic strictures of the colon. We report a case of pancolonic fibrosis due to pancreatic enzyme use.
authors.affiliation: Packard Children's Hospital, Stanford University School of Medicine, Division of Pediatric Surgery, Palo Alto, California 94304, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Moss
authors.forename: C A
authors.initials: CA
authors.lastname: Musemeche
authors.forename: R M
authors.initials: RM
authors.lastname: Feddersen
mesh_terms: D002648:Child; D003106:Colon / Q000473:pathology; D003251:Constriction, Pathologic / Q000139:chemically induced; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy*; D018450:Disease Progression; D005355:Fibrosis / Q000139:chemically induced; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology* / Q000473:pathology; D008049:Lipase / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010184:Pancreatic Extracts / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D010184:Pancreatic Extracts; D008049:Lipase