title: A novel DEAD-box RNA helicase exhibits high sequence conservation from yeast to humans.
abstract: We have identified a novel Drosophila protein, DBP80, that exhibits significant similarity to mouse mDEAD5, yeast TIF1/2, and mammalian eIF-4A. DBP80 is a member of a subclass of DEAD-box proteins that contains a distinct domain, PX(I/R)ILLKR(E/D)EETLEGIKQ(F/Y)(F/Y), in addition to the seven canonical helicase domains.
authors.affiliation: Department of Biology, Emory University, Atlanta, GA 30322, USA.
authors.forename: A
authors.initials: A
authors.lastname: Eisen
authors.forename: M
authors.initials: M
authors.lastname: Sattah
authors.forename: T
authors.initials: T
authors.lastname: Gazitt
authors.forename: K
authors.initials: K
authors.lastname: Neal
authors.forename: P
authors.initials: P
authors.lastname: Szauter
authors.forename: J
authors.initials: J
authors.lastname: Lucchesi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000737:chemistry*; D016601:RNA-Binding Proteins
chemical_list: C083965:Dbp45A protein, Drosophila; D029721:Drosophila Proteins; D019476:Insect Proteins; D016601:RNA-Binding Proteins; D012316:RNA Nucleotidyltransferases; D020365:RNA Helicases