Intestinal cell cycle regulation.
The intestinal epithelium is maintained by a balance between proliferation, differentiation and death that occurs as cells migrate up the crypt-villus axis. Cell cycle regulators such as cyclins, cyclin-dependent kinases (Cdks) and Cdk inhibitory proteins are expressed in a distinct pattern along the crypt-villus structure, suggesting their role in controlling intestinal cells. This is supported by observations that these cell cycle proteins are regulated by growth factors, nutrients and cell-cell contact in cultured intestinal epithelial cells. One of the key regulators of intestinal cell proliferation and differentiation is transforming growth factor-beta, which is expressed in the gut epithelium.
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Department of Surgery, University of Texas Medical Branch, Galveston 77555-0542, USA.
Bresnahan
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Thompson
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D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D007422:Intestines / Q000166:cytology* / Q000502:physiology; D051379:Mice; D016212:Transforming Growth Factor beta / Q000502:physiology
D016213:Cyclins; D016212:Transforming Growth Factor beta; D018844:Cyclin-Dependent Kinases