[Targeting of anticancer drug using intelligent polymers].
To fabricate the drug targeting system, it is very effective to combine passive targeting with intelligent polymeric system such as temperature-responsive polymers. We have been studying the passive targeting of anticancer drug bonded with or physically trapped in polymeric micelle derived from poly (ethylene oxide) (PEO) and poly (aspartic acid) block copolymer. On the other hand, Poly(N-isopropylacrylamide) (PIPAAm) is known to be a thermo-responsive polymer which has lower critical solution temperature (LCST, 32 degrees C). PIPAAm shows the reversible phase transition above and below LCST. Attempts to apply thermo-responsive drug carriers were made to enhance the site-specificity of polymeric micelle. Namely, novel type of polymeric micelle were prepared from block copolymers comprising N-isopropylacrylamide (IPAAm)-hydrophobic polymers. This temperature responsive micelles were expected to induce selective accumulation controlled by temperature modulation.
Aoyagi
T
T
Institute of Biomedical Engineering, Tokyo Women's Medical College.
Okano
T
T
D000180:Acrylic Resins; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008823:Micelles; D011092:Polyethylene Glycols; D011108:Polymers; D013696:Temperature
D000180:Acrylic Resins; D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D011092:Polyethylene Glycols