Genetic specificity of stress-induced anemia in rats.
There is a genetic difference in rat hemoglobin (Hb) beta-chain structure, with alternate alleles, A and B, at a single locus. This study was designed to find out whether marrow sensitivity due to gamma exposure and experimentally induced anemia in age-matched adult rats is entirely strain specific or is a combination of both strain and Hb genotype. Eight strains of inbred and outbred rats comprising AA and BB types were examined. The data indicate that there is a relationship between marrow sensitivity and Hb genotypes in response to erythropoietic stress caused by three techniques.
Datta
M C
MC
Department of Chemistry, Tuskegee University, Alabama 36088, USA.
AbdelRahman
H G
HG
Srivastava
K K
KK
Smith
G S
GS
D000483:Alleles; D000740:Anemia / Q000139:chemically induced / Q000235:genetics*; D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D004920:Erythropoiesis / Q000235:genetics / Q000528:radiation effects; D005720:Gamma Rays; D006454:Hemoglobins / Q000235:genetics*; D006470:Hemorrhage; D010659:Phenylhydrazines / Q000494:pharmacology; D011836:Radiation Tolerance / Q000235:genetics; D051381:Rats; D013045:Species Specificity; D013312:Stress, Physiological / Q000139:chemically induced / Q000235:genetics*
D006454:Hemoglobins; D010659:Phenylhydrazines; C030299:phenylhydrazine