In vitro activity of levofloxacin against a selected group of anaerobic bacteria isolated from skin and soft tissue infections.
The in vitro activity of levofloxacin was compared to the activities of ofloxacin, ciprofloxacin, ampicillin-sulbactam (2:1), cefoxitin, and metronidazole for a selected group of anaerobes (n = 175) isolated from skin and soft tissue infections by using the National Committee for Clinical Laboratory Standards-approved Wadsworth method. Ampicillin-sulbactam and cefoxitin inhibited 99% of the strains of this select group, levofloxacin and ofloxacin inhibited 73 and 50%, respectively, at 2 microg/ml, and ciprofloxacin inhibited 51% at 1 microg/ml. The geometric mean MIC of levofloxacin was lower than those of ofloxacin and ciprofloxacin for every group except Veillonella.
Wexler
H M
HM
Veterans Administration Medical Center, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90024, USA. hwexler@ucla.edu
Molitoris
E
E
Molitoris
D
D
Finegold
S M
SM
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D015169:Colony Count, Microbial; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D012874:Skin Diseases, Infectious / Q000382:microbiology*; D018461:Soft Tissue Infections / Q000382:microbiology*
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin