title: [Type IIB von Willebrand Jürgens syndrome as the cause of neonatal thrombocytopenia].
abstract: Two newborn male infants with neonatal thrombocytopenia and von Willebrand disease (vWD) in their family history were admitted two our hospital during the last two years. The second patient was later on shown to suffer from vWD type IIB, in the first case there was a typical history but no analysis of the multimeric pattern. The vWD type IIB is a rare cause for neonatal thrombocytopenia. Therapy with platelet concentrates alone is not in all cases able to correct the platelet count for more than some hours. The finding of (recurrent) thrombocytopenia and a familial history of vWD in a newborn infant is of major diagnostic value to identify cases of this rare autosomal dominant disease.
authors.affiliation: Universitäts-Kinderklinik Würzburg.
authors.forename: P
authors.initials: P
authors.lastname: Zeitler
authors.forename: H B
authors.initials: HB
authors.lastname: von Stockhausen
mesh_terms: D001780:Blood Coagulation Tests; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D005799:Genes, Dominant; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010976:Platelet Count; D017713:Platelet Transfusion; D012008:Recurrence; D013921:Thrombocytopenia / Q000097:blood / Q000235:genetics*; D016896:Treatment Outcome; D014842:von Willebrand Diseases / Q000097:blood / Q000235:genetics*