Alterations of substance P immunoreactivity in lumbar and thoracic segments of rat spinal cord in ultraviolet irradiation induced hyperalgesia of the hindpaw.
Substance P immunostaining was quantified on sections from the 4th-5th lumbar and midthoracic spinal segments of rats at the peak of hyperalgesia following ultraviolet irradiation-induced inflammation of one hindpaw. The area of the immunostaining in the lumbar dorsal horn was significantly decreased on both sides by 50%, while in the thoracic spinal cord, it was increased by 18% on the contralateral and stayed unchanged on the ipsilateral side.
Polgár
E
E
Department of Anatomy, Histology and Embryology, University Medical School, Debrecen H-4012, Hungary. ep7u@udcf.gla.ac.uk
Szûcs
P
P
Urbán
L
L
Nagy
I
I
D000818:Animals; D006614:Hindlimb / Q000528:radiation effects*; D006930:Hyperalgesia / Q000209:etiology* / Q000378:metabolism; D007158:Immunologic Techniques; D008161:Lumbosacral Region; D011833:Radiation Injuries, Experimental / Q000150:complications*; D051381:Rats; D011921:Rats, Inbred WKY; D013116:Spinal Cord / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D013909:Thorax; D014466:Ultraviolet Rays
D013373:Substance P