title: Combination of LC-MS and LC-NMR as a Tool for the Structure Determination of Natural Products
abstract: Application of both LC-MS and LC-NMR to a partially purified extract of Vernonia fastigiataled to the direct identification of antibacterial sesquiterpene lactones 1-9 without isolation of individual compounds. The rapid structural analysis of both major and minor components of this class of compounds demonstrated the power of structure-guided screening as a complementary method to assay-guided screening.
authors.affiliation: Department of Chemistry, University of Hohenheim, D-70593 Stuttgart, Germany, and Varian GmbH, D-64289 Darmstadt, Germany.
authors.initials: B
authors.lastname: Vogler
authors.initials: I
authors.lastname: Klaiber
authors.initials: G
authors.lastname: Roos
authors.initials: CU
authors.lastname: Walter
authors.initials: W
authors.lastname: Hiller
authors.initials: P
authors.lastname: Sandor
authors.initials: W
authors.lastname: Kraus