Distribution of substance P receptor binding in dorsal column nuclei of rat, cat, monkey and human.
In the present study, substance P receptor binding was localized in the dorsal column nuclei (DCN) of the rat, cat, monkey, and human. Bolton-Hunter-labeled [125I]substance P binding was most concentrated in the cell nests of the core region, but was present throughout the DCN of each species. The distribution of substance P receptors may reconcile apparent mismatches between the widespread responsiveness of DCN neurons to substance P and the restricted distribution of substance P containing afferents.
Schwark
H D
HD
Department of Biological Sciences, University of North Texas, P.O. Box 305220, Denton, TX 76203-5220, USA. schwark@unt.edu
Petit
M J
MJ
Fuchs
J L
JL
D000818:Animals; D001345:Autoradiography; D002415:Cats / Q000378:metabolism*; D006801:Humans; D008254:Macaca nemestrina / Q000378:metabolism*; D051381:Rats / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D013388:Succinimides / Q000378:metabolism; D014018:Tissue Distribution
C043194:Bolton Hunter reagent-substance P conjugate; D013388:Succinimides; D013373:Substance P