Photic stimulation-induced alteration of brain energy metabolism measured by 31P-MR spectroscopy in patients with MELAS.
We examined brain energy metabolism by phosphorus-31 magnetic resonance spectroscopy (31P-MRS) in the occipital cortex in a mother and a daughter with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) during photic stimulation. The peak area ratio of phosphocreatine markedly decreased during photic stimulation, and subsequently increased after the stimulation. This method, photic stimulation-31P-MRS, may be useful in assessing brain energy metabolism in neurological diseases.
Kato
T
T
Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Japan. tadafumi-tky@umin.ac.jp
Murashita
J
J
Shioiri
T
T
Terada
M
M
Inubushi
T
T
Kato
N
N
D000328:Adult; D001921:Brain / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D017241:MELAS Syndrome / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010759:Phosphorus Isotopes; D010775:Photic Stimulation
D010710:Phosphates; D010759:Phosphorus Isotopes; D010725:Phosphocreatine