title: Recovery of neglect after right hemispheric damage: H2(15)O positron emission tomographic activation study.
abstract: BACKGROUND
  The neural correlates of recovery of unilateral neglect (ULN), as well as of other consequences of focal brain damage, are largely unknown. Functional neuroimaging methods (in particular, positron emission tomography [PET]) can be applied to the in vivo study of recovery mechanisms in neurologic patients.
  
  
  OBJECTIVE
  To evaluate the functional cerebral correlates of recovery from ULN in patients with right-sided lesions, with the use of a PET activation paradigm.
  
  
  METHODS
  Study of 3 patients with cerebrovascular lesions that involved corticosubcortical (patient 1) or subcortical (patients 2 and 3) areas of the right hemisphere. Unilateral neglect was tested twice, before and after completion of a 2-month rehabilitation program, after which all 3 patients showed considerable improvement. Similarly, 2 PET examinations were performed, before and after recovery, during the performance of a visuospatial task requiring the patients to detect and respond to visual targets moving on a computer screen from the right to the left visual hemifield (experimental condition). The cerebral activation was compared with a baseline task in which subjects responded to a black dot flashing in a fixed position of the right hemifield.
  
  
  RESULTS
  The brain areas activated by the performance of the visuospatial task before and after recovery were compared. In all 3 patients, the regions notably more active after recovery were almost exclusively found in right-sided cortical areas and largely overlapped with those observed in a group of 4 normal subjects performing the same task. Other areas, which have been shown to be involved in attentional and oculomotor tasks in other PET studies, were also activated in patients with ULN.
  
  
  CONCLUSIONS
  The behavioral recovery of ULN in these patients with predominantly subcortical lesions is mainly associated with cerebral activations in cortical regions similar to those observed in normal subjects. There is some evidence of functional reorganization in individual subjects, which involves other areas related to space representation and exploration.
authors.affiliation: Faculty of Psychology, Universita' di Roma La Sapienza, Center for Research of Neuropsychology-Istituto di Ricovero e Cura a Carattere Scientifico Clinica S. Lucia, Rome, Italy. PIZZAMIGLIO@UNIROMA1.IT
authors.forename: L
authors.initials: L
authors.lastname: Pizzamiglio
authors.forename: D
authors.initials: D
authors.lastname: Perani
authors.forename: S F
authors.initials: SF
authors.lastname: Cappa
authors.forename: G
authors.initials: G
authors.lastname: Vallar
authors.forename: S
authors.initials: S
authors.lastname: Paolucci
authors.forename: F
authors.initials: F
authors.lastname: Grassi
authors.forename: E
authors.initials: E
authors.lastname: Paulesu
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000523:psychology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D013037:Spatial Behavior / Q000502:physiology*; D014055:Tomography, Emission-Computed