title: Cholinergic mechanisms in the neurocontrol of the branchial heart of the cephalopod Sepia officinalis L.
abstract: Cholinergic mechanisms controlling the branchial heart of the cephalopod Sepia officinalis L. were examined. In vitro tests indicate that acetylcholine (ACh) exerts a dose-dependent negative inotropic and chronotropic effect. Although the nicotinic agonists carbachol and nicotine mimic the effects of ACh closely, the muscarinic agonists pilocarpine, muscarine and oxotremorine induce only a slight inhibition of amplitude and frequency. Other agents tested (including atropine, pirencepine, hexamethonium, tetraethylammonium (TEA), d-tubocurarine and alpha-bungarotoxin) confirm that the acetylcholine receptor in branchial heart muscle is probably nicotinic.
authors.affiliation: Institut für Allgemeine und Spezielle Zoologie, Justus-Liebig-Universität, Giessen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Gebauer
authors.forename: B
authors.initials: B
authors.lastname: Versen
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D001934:Branchial Region / Q000502:physiology*; D002038:Bungarotoxins / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D018738:Hexamethonium / Q000494:pharmacology; D008974:Mollusca / Q000502:physiology*; D009116:Muscarine / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology; D010095:Oxotremorine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000502:physiology*; D019789:Tetraethylammonium / Q000494:pharmacology; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D002038:Bungarotoxins; D011950:Receptors, Cholinergic; D010862:Pilocarpine; D018738:Hexamethonium; D001115:Arecoline; D010095:Oxotremorine; D019789:Tetraethylammonium; D009538:Nicotine; D009116:Muscarine; D002217:Carbachol; D000109:Acetylcholine; D014403:Tubocurarine