Involvement of the central catecholaminergic system in nicotine-induced tail-tremor in rats.
The effect of 6-hydroxydopamine on repeated nicotine-induced tail-tremor was investigated in rats. Tail-tremor induced by nicotine (0.5 mg/kg/day, subcutaneously) became more pronounced in intensity with daily administration for 9 days. Rats pretreated with 6-hydroxydopamine (250 micrograms, intracerebroventricularly) showed almost the maximum degree of tail-tremor during the whole experimental period. However, in rats pretreated with 6-hydroxydopamine plus desipramine, enhancement of tail-tremor was slight in the beginning but increased with the daily nicotine administration. Fourteen-day administration of nicotine did not result in significant changes in noradrenaline and dopamine levels in the cortex, hypothalamus, striatum and nucleus accumbens. These results suggest that nicotine-induced tail-tremor is associated with the supersensitivity of postsynaptic catecholaminergic receptors in the central nervous system, and that the noradrenergic system may be more important than the dopaminergic system in this phenomenon.
Suemaru
K
K
Division of Pharmacy, Misasa Medical Branch, Okayama University Medical School, Tottori, Japan.
Kawakami
Y
Y
Araki
H
H
Gomita
Y
Y
Tanizaki
Y
Y
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism*; D004334:Drug Administration Schedule; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D009538:Nicotine / Q000633:toxicity*; D016627:Oxidopamine / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D013623:Tail; D014202:Tremor / Q000139:chemically induced* / Q000378:metabolism
D002395:Catecholamines; D009538:Nicotine; D016627:Oxidopamine