[The treatment of malaria].
The diagnosis of malaria should include the species involved and in case of P. falciparum infection the parasitaemia index: the percentage of the infected red cells. P. vivax, ovale and malariae infection are treated with chloroquine, in case of P. vivax and ovale malaria followed by primaquine. Mefloquine and halofantrine are indicated for chloroquine-resistant vivax infections. Advice on management and treatment is different for mild and severe (> or = 5% infected erythrocytes or presence of complications) P. falciparum infections. Mild infections may be treated on an outpatient basis. In severe infections quinine has to be started immediately, while frequent checks of vital functions and blood parameters are indicated. New treatment options are the use of artemisinine (preparations) or atovaquone, both efficacious and low in adverse effects and toxicity.
Kager
P A
PA
Afd. Inwendige Geneeskunde, onderafd. Infectieziekten, Tropische Geneeskunde en Aids, Universiteit van Amsterdam/Academisch Medisch Centrum.
Zijlmans
C W
CW
Boele van Hensbroek
M
M
Wetsteyn
J C
JC
D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D002738:Chloroquine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008288:Malaria / Q000188:drug therapy*; D016778:Malaria, Falciparum / Q000188:drug therapy; D016780:Malaria, Vivax / Q000188:drug therapy; D015767:Mefloquine / Q000627:therapeutic use; D010616:Phenanthrenes / Q000627:therapeutic use; D011247:Pregnancy; D011319:Primaquine / Q000627:therapeutic use
D000962:Antimalarials; D010616:Phenanthrenes; D002738:Chloroquine; D011319:Primaquine; C023768:halofantrine; D015767:Mefloquine