title: Analysis and design of three-stranded coiled coils and three-helix bundles.
abstract: Three-stranded coiled coils and three-helix bundles are increasingly being identified in proteins. Design and engineering on the scaffolds of these motifs is a potential route towards combating associated viral infections as well as introducing novel functional sites.
authors.affiliation: Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia 19104-6059, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Schneider
authors.forename: A
authors.initials: A
authors.lastname: Lombardi
authors.forename: W F
authors.initials: WF
authors.lastname: DeGrado
mesh_terms: D001665:Binding Sites; D002352:Carrier Proteins / Q000737:chemistry; D037102:Lectins / Q000737:chemistry; D037241:Mannose-Binding Lectins; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D014759:Viral Envelope Proteins / Q000737:chemistry
chemical_list: D002352:Carrier Proteins; D037102:Lectins; D037241:Mannose-Binding Lectins; D011506:Proteins; D014759:Viral Envelope Proteins