title: [Systemic effects of inhaled corticosteroids. Various pending questions].
abstract: Inhaled steroids play a central and undisputed role in the management of Bronchial Asthma, since inflammation has been recognised as the main physiopathological mechanism in this disease. Indeed, the earlier introduction of inhaled steroids in the therapy of Bronchial Asthma is currently being recommended by several authors. However, accompanying the much broader use of these drugs, concerns about the possibility of induction of adverse systemic effects have appeared more and more frequently in the medical community and in medical literature. This article addresses the main concerns related to the systemic effects of inhaled corticotherapy, critically reviewing the clinical significance of some of the more relevant published studies.
authors.affiliation: Serviço de Medicina III, Hospital de Santa Maria, Faculdade de Medicina de Lisboa.
authors.forename: M B
authors.initials: MB
authors.lastname: Ferreira
authors.forename: E
authors.initials: E
authors.lastname: Pedro
authors.forename: M A
authors.initials: MA
authors.lastname: Barbosa
authors.forename: A G
authors.initials: AG
authors.lastname: Carlos
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006128:Growth / Q000187:drug effects; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D050356:Lipid Metabolism; D010913:Pituitary-Adrenal System / Q000187:drug effects
chemical_list: D000305:Adrenal Cortex Hormones; D005947:Glucose