Drug induced rhabdomyolysis: case report.
Rhabdomyolysis results from skeletal muscle injury leading to the release of intracellular contents into blood and urine. Its diverse aetiology includes severe exercise, muscle trauma or ischaemia, metabolic disorders, infections and exposure to drugs and toxins. Known risk factors include heredity disorders of glycogen and lipid metabolism as well as a history of substance abuse. A case of rhabdomyolysis associated with exposure to opiates and benzodiazepines is described and the pathogenesis and treatment are reviewed. The rhabdomyolysis was complicated by acute renal failure; the patient fully recovered. It is suggested that rhabdomyolysis should be borne in mind in patients presenting with altered mental status, or fluid and electrolyte abnormalities, in particular, if they also give a history of substance abuse.
Larbi
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Department of Pharmacology and Internal Medicine, King Faisal University, College of Medicine and Medical Sciences, Dammam.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000701:Analgesics, Opioid / Q000506:poisoning*; D014151:Anti-Anxiety Agents / Q000506:poisoning*; D001569:Benzodiazepines; D006801:Humans; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D019966:Substance-Related Disorders / Q000150:complications
D000701:Analgesics, Opioid; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines