title: Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.
abstract: Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies. We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression. Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.
authors.affiliation: Department of Emergency Medicine, Western Pennsylvania Hospital, Pittsburgh 15224, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Roberge
authors.forename: N S
authors.initials: NS
authors.lastname: Srinivasa
authors.forename: L R
authors.initials: LR
authors.lastname: Frank
authors.forename: L
authors.initials: L
authors.lastname: Scorza
authors.forename: E P
authors.initials: EP
authors.lastname: Krenzelok
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000187:drug effects / Q000473:pathology; D001639:Bicarbonates / Q000627:therapeutic use; D001929:Brain Edema / Q000139:chemically induced / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D000432:Methanol / Q000506:poisoning*; D009336:Necrosis; D011699:Putamen / Q000000981:diagnostic imaging / Q000187:drug effects*; D012997:Solvents / Q000506:poisoning*; D014057:Tomography, X-Ray Computed
chemical_list: D001639:Bicarbonates; D012997:Solvents; D000432:Methanol