title: Redundant down-regulation pathways for p53.
abstract: The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and active p53 isoforms. The mechanisms prolonging p53 half life, following irradiation, are also discussed.
authors.affiliation: Laboratory of Molecular Biology, University of Florence, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cinelli
authors.forename: L
authors.initials: L
authors.lastname: Magnelli
authors.forename: V
authors.initials: V
authors.lastname: Chiarugi
mesh_terms: D000818:Animals; D015536:Down-Regulation / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007536:Isomerism; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*
chemical_list: D016159:Tumor Suppressor Protein p53