title: T-cell-rich B-cell lymphoma and Epstein-Barr virus infection of the uterus in a postmenopausal patient with an intrauterine contraceptive device in place for over 20 years.
abstract: Although secondary involvement of the female genital tract occurs in up to 40% of cases of disseminated lymphomas, lymphomas presenting with primary female genital tract symptomatology are very unusual. We report a case of T-cell-rich B-cell lymphoma (TCRBCL) arising in the uterine corpus of a 57-year-old female who carried an intrauterine contraceptive device (IUD) for over 20 years. Malignant lymphoid cells expressed the Epstein-Barr virus (EBV) late membrane protein (LMP), a feature described in TCRBCL but not previously reported in primary uterine lymphomas. To our knowledge, this is the first reported case of a TCRBCL of the uterus.
authors.affiliation: Department of Laboratory Medicine, National Naval Medical Center, Bethesda, Maryland, USA.
authors.forename: P D
authors.initials: PD
authors.lastname: Gutman
authors.forename: J P
authors.initials: JP
authors.lastname: Williams
authors.forename: G S
authors.initials: GS
authors.lastname: Dveksler
authors.forename: K
authors.initials: K
authors.lastname: Hoffmeister
authors.forename: J D
authors.initials: JD
authors.lastname: Cotelingam
mesh_terms: D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006566:Herpesviridae Infections / Q000209:etiology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007434:Intrauterine Devices / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000473:pathology* / Q000821:virology; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D017698:Postmenopause; D013601:T-Lymphocytes / Q000473:pathology*; D014412:Tumor Virus Infections / Q000209:etiology*; D014591:Uterine Diseases / Q000209:etiology / Q000821:virology*; D014594:Uterine Neoplasms / Q000209:etiology / Q000821:virology*
chemical_list: D004273:DNA, Neoplasm