title: Heterogeneous responsiveness of normolipemic women to n-3 long chain fatty acid supplementation. Changes in serum lipids and apoproteins.
abstract: The effect of 10 day-low dosage of n-3 long chain fatty acids (390 mg/day of EPA and 252 mg/day of DHA) on lipid and apolipoprotein (Apo) concentrations has been studied in nine normolipidaemic women aged 28.9 +/- 4.2 years. n-3 fatty acid supplementation did not significantly decrease total cholesterol and triglyceride levels but markedly decreased the Apo A1 and Apo B concentrations (12.7%, p < 0.01 and 23.1%, p < 0.001, respectively), while the Apo A1/Apo B ratio significantly increased (14.8%, p < 0.02). In contrast to the individual variations found for triglycerides and cholesterol, Apo changes indicate a fairly homogeneous response to the fish oil supplement. In seven women Apo A1 decreased (> 10%), whereas Apo B decreased (> 10%) in all of them. The Apo A1/Apo B ratio increased (> 10%) in five of these nine women. Changes in Apo A-1 and Apo B did not significantly correlate with changes in serum lipids. These findings suggest that short-term supplementation with low amount of n-3 long chain fatty acids, EPA and DHA, influences the serum Apo content more than the lipid levels in normolipidaemic women.
authors.affiliation: Departamento de Nutrición (Sección Lípidos), Facultad de Farmacia, Universidad Complutense, Madrid, Spain. frasan@eucmax.sim.ucm.es
authors.forename: F J
authors.initials: FJ
authors.lastname: Sánchez-Muniz
authors.forename: S
authors.initials: S
authors.lastname: Bastida
authors.forename: E
authors.initials: E
authors.lastname: Quintas
authors.forename: M C
authors.initials: MC
authors.lastname: Merinero
authors.forename: S
authors.initials: S
authors.lastname: Rodríguez-Gil
mesh_terms: D000284:Administration, Oral; D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood / Q000187:drug effects; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001055:Apolipoproteins B; D015525:Fatty Acids, Omega-3; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol