title: Fetal loss after early detection of heart motion in infertility patients. Prognostic factors.
abstract: OBJECTIVE
  To evaluate the incidence and prognosticators of spontaneous abortion (< 20 weeks' gestation) in an infertile population after early documentation of fetal cardiac activity.
  
  
  METHODS
  Retrospective chart review. We examined the incidence of spontaneous abortion in 231 clinical pregnancies with 259 fetuses documented to be viable by transvaginal sonography 28-38 days after ovulation. The population was an unselected group of infertility patients with no history of recurrent pregnancy loss. Maternal age and presence of multiple gestations were analyzed as separate variables by chi 2 testing.
  
  
  RESULTS
  The incidence of spontaneous abortion among all fetuses was 9.6% (95% confidence interval [CI], 6.1-13.2%) and among singleton gestations was 7.7% (95% CI, 4.0-11.3%). Women with multiple gestations were more likely to suffer spontaneous fetal loss as compared to women with singleton gestations (18 vs. 7.6%, P < .05). In addition, women aged 35 and above with singleton pregnancies showed a significantly increased rate of fetal loss (13.4 vs. 4.9%, P < .05) when compared with younger women.
  
  
  CONCLUSIONS
  Women > or = 35 years old and those with multiple gestations were significantly more likely to suffer late first- or early second-trimester fetal loss even after detection of fetal cardiac activity. These patients should be counseled differently than younger women with singleton pregnancies, and increased monitoring may be indicated.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tennessee Medical Center, Knoxville, TN 37920-6999, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Keenan
authors.forename: S
authors.initials: S
authors.lastname: Rizvi
authors.forename: M R
authors.initials: MR
authors.lastname: Caudle
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D000367:Age Factors; D005260:Female; D005313:Fetal Death; D006340:Heart Rate, Fetal; D006801:Humans; D015994:Incidence; D007246:Infertility / Q000628:therapy*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment