Deletion of the M6P/IGF2r gene in primary hepatocellular carcinoma.
To evaluate the different alteration patterns of the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2r) gene in hepatocellular carcinoma (HCC), 41 HCCs were screened for homozygous deletion and loss of heterozygosity (LOH) at the M6P/IGF2r gene with a dinucleotide repeat polymorphic marker. Of these, three (8.8%) were heterozygous and LOH was observed in two (66.7%) of these informative cases. Five (14.7%) out of 34 informative cases showed homozygous deletions for the dinucleotide repeat polymorphic marker. The frequent allelic loss and homozygous deletion of the M6P/ IGF2r gene suggest that the M6P/IGF2r gene functions as a tumor suppressor gene in the development of HCC.
Piao
Z
Z
Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea.
Choi
Y
Y
Park
C
C
Lee
W J
WJ
Park
J H
JH
Kim
H
H
D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D002896:Chromosomes, Human, Pair 6; D004273:DNA, Neoplasm / Q000235:genetics*; D004268:DNA-Binding Proteins; D018900:Dinucleotide Repeats; D017353:Gene Deletion; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D019656:Loss of Heterozygosity; D017527:Receptor, IGF Type 2 / Q000235:genetics*; D051901:Smad4 Protein; D015534:Trans-Activators / Q000235:genetics
D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D017527:Receptor, IGF Type 2; C497796:SMAD4 protein, human; D051901:Smad4 Protein; D015534:Trans-Activators