Structure and expression of Wnt13, a novel mouse Wnt2 related gene.
We have identified a novel mouse member of the Wnt family, Wnt13. Among mouse Wnt genes, Wnt13 is most closely related to Wnt2. Sequence comparisons and chromosomal localization strongly suggest that Wnt13, rather than Wnt2, is the mouse orthologue of both the human WNT13 and Xenopus XWnt2 genes. Wnt13 is expressed in the embryonic mesoderm during gastrulation. At later stages, transcripts are detected in the dorsal midline of the diencephalon and mesencephalon, the heart primordia, the periphery of the lung bud and the otic and optic vesicles. These data suggest that Wnt13 function might partially overlap with those of other Wnt genes in the cell signaling mechanisms controlling mesoderm specification during gastrulation and some aspects of brain, heart and lung formation.
Zakin
L D
LD
Unité d'Embryologie Moléculaire, Unité de Recherche Associée 1947, Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Dr. Roux 75724, Paris Cedex 15, France.
Mazan
S
S
Maury
M
M
Martin
N
N
Guénet
J L
JL
Brûlet
P
P
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D006023:Glycoproteins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D051153:Wnt Proteins; D051154:Wnt2 Protein; D014981:Xenopus
D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; C115496:WNT2B protein, human; D051153:Wnt Proteins; D051154:Wnt2 Protein; C492031:Wnt2b protein, mouse