Genetic evidence for posterior specification by convergent extension in the Xenopus embryo.
Genetic studies substantiate that mesodermal convergent extension expressed behind the anteroposterior borderline, in the form of a gradient with the posterior apex after gastrulation, regulates morphogenesis of the posterior zone at the dorsal and dorso-lateral levels which is in full agreement with the model of dorsalization-caudalization. In contrast, how anteroposterior specification of mesodermal tissues occurs at the ventral and latero-ventral levels is not yet understood.
Yamada
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Swiss Institute for Experimental Cancer Research, Epalinges.
Modak
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SP
D000818:Animals; D052004:Bone Morphogenetic Protein Receptors; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D047108:Embryonic Development; D004789:Enzyme Activation; D005326:Fetal Proteins; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000494:pharmacology; D005775:Gastrula / Q000378:metabolism / Q000648:ultrastructure; D018507:Gene Expression Regulation, Developmental; D005799:Genes, Dominant; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D008648:Mesoderm / Q000378:metabolism*; D009024:Morphogenesis / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000502:physiology; D017978:Receptors, Growth Factor; D019170:Somites / Q000648:ultrastructure; D020825:T-Box Domain Proteins; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology* / Q000235:genetics; D000098908:Brachyury Protein
D052004:Bone Morphogenetic Protein Receptors; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D004268:DNA-Binding Proteins; D005326:Fetal Proteins; D005346:Fibroblast Growth Factors; D018398:Homeodomain Proteins; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D017978:Receptors, Growth Factor; D020825:T-Box Domain Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D029867:Xenopus Proteins; D000098908:Brachyury Protein; C094040:EVX1 protein, Xenopus; C080209:Not protein, Xenopus