Down-regulation of protein kinase C-alpha detected in human colorectal cancer.
The down-regulation of protein kinase C (PKC) was examined by Western blot procedure on about 30 tissue samples derived from human colorectal cancer and the corresponding normal mucosa. PKC-alpha down-regulation was detected in 60% of the cancer tissues compared with the respective normal mucosa and was observed in a higher frequency with the tissues under more advanced cancer stages. However, the frequencies of the down-regulation of PKC-delta and PKC-zeta were lower than that of PKC-alpha. These results suggest that a decreased level of PKC-alpha may affect the cell growth and tumor promotion in colorectal tissue.
Suga
K
K
Department of Pathological Biochemistry, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.
Sugimoto
I
I
Ito
H
H
Hashimoto
E
E
D015179:Colorectal Neoplasms / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D015151:Immunoblotting; D007413:Intestinal Mucosa / Q000201:enzymology; D007527:Isoenzymes; D011493:Protein Kinase C / Q000276:immunology / Q000378:metabolism*
D007527:Isoenzymes; D011493:Protein Kinase C