title: Stroke: a double-edged sword for cleaving clots?
abstract: The discovery that tissue plasminogen activator can promote neuronal degeneration has uncovered a novel pathway leading to neuronal cell death and raises important issues concerning the use of tissue plasminogen activator as a thrombolytic therapy for stroke.
authors.affiliation: The CNS Inflammation Group, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Anthony
authors.forename: V H
authors.initials: VH
authors.lastname: Perry
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D016923:Cell Death; D006801:Humans; D051379:Mice; D017628:Microglia; D009474:Neurons / Q000473:pathology*; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D010959:Tissue Plasminogen Activator