[Allopurinol as an inducer of acute graft-versus-host-like drug reaction. Case report with review of the literature].
Although drug eruptions resembling graft-versus-host disease are rare, GvH-like reactions to the sulfhydryl group of drugs (penicillamine, captopril, gold sodium), phenobarbital and hepatitis vaccine have been described. Clinical reports concerning acute GvH-like drug rash are very uncommon and restricted to acetylsalicylic acid and spironolactone. We report on a patient who developed an acute GvH-like drug reaction caused by allopurinol. To our knowledge this variant of cytotoxic drug eruption has not yet been reported in literature.
Jappe
U
U
Klinik und Poliklinik für Dermatologie und Venerologie, Otto-von-Guericke-Universität Magdeburg.
Franke
I
I
Wendekamm
U
U
Gollnick
H
H
D000208:Acute Disease; D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage / Q000009:adverse effects*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003875:Drug Eruptions / Q000175:diagnosis* / Q000473:pathology; D006086:Graft vs Host Disease / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D012867:Skin / Q000473:pathology; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery
D000964:Antimetabolites, Antineoplastic; D000493:Allopurinol