Post-lesion up-regulation of 5-HT1B binding sites in the suprachiasmatic nucleus may be reversed after spontaneous or graft-induced serotonin reinnervation.
We have previously reported that selective axotomy of serotoninergic neurons produced by an intraventricular injection of 5, 7-dihydroxytryptamine is followed by an increase in 5-HT1B binding sites in the suprachiasmatic nucleus of the hypothalamus. This post-lesion up-regulation is shown here to be spontaneously reversed after long-term survival in spite of an incomplete reinnervation of the nucleus. Recovery may be accelerated by fetal raphe transplants that produce more rapid reinnervation.
Manrique
C
C
Laboratoire de Neuroendocrinologie Expérimentale, INSERM U297, Institut Fédératif Jean Roche, Faculté de Médecine Nord, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France.
Bosler
O
O
Becquet
D
D
Héry
F
F
Faudon
M
M
François-Bellan
A M
AM
D000818:Animals; D016332:Fetal Tissue Transplantation; D007276:Injections, Intraventricular; D008297:Male; D009474:Neurons / Q000502:physiology; D011903:Raphe Nuclei / Q000196:embryology / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000502:physiology*; D015854:Up-Regulation
D011985:Receptors, Serotonin