title: Synthesis and antibacterial evaluation of novel water-soluble organic peroxides.
abstract: A set of new water-soluble organic peroxides has been synthesized and evaluated for in vitro antibacterial activity as part of an effort to develop new antibacterial agents for the treatment of acne vulgaris. The water solubility of these new dialkyl peroxides and peroxyesters was achieved by incorporating either a quaternary ammonium group or a polyethylene glycol moiety. These peroxides are effective against both gram-positive and gram-negative bacteria and have a prolonged activity compared to that of benzoyl peroxide and other peroxide-type antiseptic agents. Among them 4-[[(tert-butylperoxy)carbonyl]benzyl]triethylammonium chloride and [10-(tert-butylperoxy)decyl]trimethylammonium bromide have the broadest antimicrobial spectrums. We have shown that the oxidizing properties of the dioxy group of these compounds are responsible for their antibacterial activities.
authors.affiliation: Department of Chemistry, Clarkson University, Potsdam, New York 13699, USA.
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: D
authors.initials: D
authors.lastname: Knaebel
authors.forename: L
authors.initials: L
authors.lastname: Luck
authors.forename: Y
authors.initials: Y
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010545:Peroxides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D010545:Peroxides