[The intestine as an immunological organ].
The intestinal mucosa is in close contact with a large number of foreign antigens and mitogenic substances in the gut lumen. To protect the host against invasion of potential pathogens or an inappropriate immune response to the enormous number of antigens, a highly specialized immune system in the intestinal mucosa has developed, the so-called gut-associated lymphoid tissue (GALT). The passage of viable bacteria from the gastrointestinal tract through the epithelial mucosa is called bacterial translocation. Bacterial translocation in critically ill patients may lead to a significant incidence of systemic sepsis. This has attracted much clinical interest, as it has been shown that disturbances of the GALT and malnutrition itself, impair various aspects of barrier function. Enteral nutrition seems to be superior to parenteral nutrition in maintaining the functional barrier of the gut. Defined dietary variable (fibre, glutamine) influence bacterial translocation. Future therapeutic strategies should therefore concentrate on early enteral feeding in traumatised patients to reduce the incidence of bacterial translocation and septic complications.
Stallmach
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Medizinische Klinik und Poliklinik, Universitätskliniken des Saarlandes, Homburg, Bundesrepublik Deutschland.
Zeitz
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D018988:Bacterial Translocation / Q000276:immunology; D003422:Critical Care; D004750:Enteral Nutrition; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D011502:Protein-Energy Malnutrition / Q000276:immunology; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology