Alternative therapies for neonatal autoimmune thrombocytopenia.
OBJECTIVE
This study was performed to test whether corticosteroids were superior to intravenous immunoglobulins (IVIG) in the treatment of neonatal autoimmune thrombocytopenia (NAT).


METHODS
All cases received IVIG, and unresponsive cases received corticosteroids.


RESULTS
Of 7 babies who received IVIG, only 1 responded. The 6 remaining cases received corticosteroids thereafter, and all of them responded well to this therapy.


CONCLUSIONS
Corticosteroids may be more effective than IVIG in NAT.
Ovali
F
F
Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul University, Turkey.
Samanci
N
N
Ermiş
B
B
Akdoğan
Z
Z
Dağoğlu
T
T
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000517:prevention & control; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007231:Infant, Newborn; D008775:Methylprednisolone / Q000627:therapeutic use; D010976:Platelet Count; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000276:immunology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D013921:Thrombocytopenia / Q000151:congenital / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D008775:Methylprednisolone