[Effect of escharectomy during burn shock stage on bacterial and endotoxic translocation from the gut].
120 SPF rats (Wistar) were randomly divided into 3 groups (1) simple skin grafting group (Group A). (2) Escharectomy during burn shock group (Group B). (3) Routine escharectomy group (Group C) Full-thickness burn of 30% TBSA was produced in Group B and Group C. One hour after scald intravenous fluid replacement was instituted. First stage escharectomy has been performed 24 hours after burn and 5 days postburn. The results demonstrated that the contents of both plasma LPS and TNF in Group B were significantly lower as compared with these in Group C. Our data indicated escharectomy during burn shock would effectively eliminate the effects of the endotoxemia. Endotoxin play an important role in the bacterial and endotoxic translocation.
Gao
W
W
304th Hospital of People's Liberation Army, Beijing.
Sheng
Z
Z
Guo
Z
Z
D000818:Animals; D018988:Bacterial Translocation; D002056:Burns / Q000150:complications*; D019446:Endotoxemia / Q000517:prevention & control; D008070:Lipopolysaccharides / Q000097:blood; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012772:Shock, Septic / Q000382:microbiology* / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha