title: [Intraoperative determination of parathyroid hormone--an alternative to preoperative localization diagnosis].
abstract: The results of localization procedures in hyperparathyroidism are not satisfying and amount to 65% for ultrasonography, 63% for CT-scan, 75% for MRI, and 74% for Tc-Mibi scintigraphy. Since 1994, we have performed intraoperative measurement of PTH with a modified immunochemiluminiscence assay in 44 patients. Ten minutes after exstirpation of pathological parathyroid glands, the PTH concentration decreases to less than 40% of the starting PTH level. We think that intraoperative PTH measurement is a rapid and safe method for controlling the success of surgery in HPT and makes preoperative localization procedures unnecessary.
authors.affiliation: Klinik und Poliklinik für Viszeral-, Thorax- und Gefässchirurgie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden.
authors.forename: M
authors.initials: M
authors.lastname: Nagel
authors.forename: D
authors.initials: D
authors.lastname: Ockert
authors.forename: T
authors.initials: T
authors.lastname: Zimmermann
authors.forename: H D
authors.initials: HD
authors.lastname: Saeger
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D003955:Diagnostic Tests, Routine; D005629:Frozen Sections; D006801:Humans; D006961:Hyperparathyroidism / Q000473:pathology / Q000601:surgery*; D006962:Hyperparathyroidism, Secondary / Q000473:pathology / Q000601:surgery*; D008856:Microscopy, Fluorescence; D010280:Parathyroid Glands / Q000473:pathology*; D010281:Parathyroid Hormone / Q000032:analysis*; D010282:Parathyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D016105:Parathyroidectomy; D011379:Prognosis; D012016:Reference Values; D012086:Reoperation
chemical_list: D010281:Parathyroid Hormone
vernacular_title: Die intraoperative Bestimmung des Parathormons--eine Alternative zur präoperativen Lokalisationsdiagnostik.