[The inhibitory effect of water-soluble and liposomal beta-carotene on various models of carcinogenesis].
The inhibitory effects of the newly-developed forms of beta-carotene--water-soluble and liposomal--have been studied in rats and mice bearing tumors induced in 4 models of carcinogenesis. Mammary tumors were induced by single injections of 1 mg methylnitrosourea into each gland. Esophageal tumors were induced in male rats by intragastric administration of 3 mg/kg methylbenzylnitrosoamine, thrice a week for 4 weeks. Tumors of the vagina and cervix uteri were induced by intravaginal painting with 25 mkg dimethylbenz(a)anthracene, twice a week for 6 weeks. Tumors of the lung were induced in female mice by intraperitoneal injection of 1 g/kg urethane, once a week for 6 weeks. With models I-III, animals received water-soluble beta-carotene (Aquiton-10) with drinking water (200 mg/I), on completion of carcinogen treatment and for another 9-12 months until the end of experiment. Urethane-treated mice received liposomal beta-carotene with drinking water (60 mg/l) 10 days before the beginning of carcinogen treatment and for another 6 months until the end experiment. Water-soluble beta-carotene failed to influence the carcinogenesis in the mammary gland and esophagus in rats; however, it significantly inhibited carcinoma development in murine vagina and cervix uteri (47.0%). Liposomal beta-carotene significantly inhibited lung adenomas (46.4%) and mammary carcinomas (55.6%) in urethane-treated mice.
Aleksandrov
V A
VA
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF; State Research Institute of Super-Pure Biopreparations, St. Petersburg.
Bespalov
V G
VG
Petrov
A S
AS
Avtushenko
S S
SS
D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000517:prevention & control; D005260:Female; D008081:Liposomes; D008175:Lung Neoplasms / Q000517:prevention & control; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D012995:Solubility; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control; D014625:Vaginal Neoplasms / Q000517:prevention & control; D014867:Water; D019207:beta Carotene / Q000008:administration & dosage / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D008081:Liposomes; D019207:beta Carotene; D014867:Water
Ingibiruiushchaia aktivnost' vodorastvorimogo i liposomal'nogo beta-karotina na razlichnykh modeliakh kantserogeneza.