title: [Serum levels of carboxyterminal propeptide of type I procollagen (PICP), cross-linked carboxyterminal telopeptide region of type I collagen (ICTP) and carboxyterminal parathyroid hormone-related protein (C-PTHrP) in hematological malignancies with bone lesions and hypercalcemia].
abstract: We measured the levels of carboxyterminal propeptide of type I procollagen (PICP), cross-linked carboxyterminal telopeptide region of type I collagen (ICTP) and carboxyterminal parothyroid hormone-related protein (C-PTHrP) in serum of patients with hematological malignancies. ICTP and C-PTHrP levels in serum of multiple myeloma (MM), non-Hodgkin's lymphoma (NHL) and adult T-cell leukemia (ATL) patients with bone lesions and hypercalcemia were significantly higher than those of patients without bone lesions and hypercalcemia. ICTP and C-PTHrP levels in ATL were significantly higher than in MM and NHL. There was a correlation between ICTP and C-PTHrP in serum of ATL patients, but no correlation in MM and NHL. Serum ICTP levels tended to correlate with serum beta 2-microglobulin and survival in patients with MM. Therefore, ICTP and C-PTHrP levels in serum may be useful in the diagnosis of bone lesions and hypercalcemia in hematological malignancies. In particular, ICTP may be a useful bone resorption marker in MM.
authors.affiliation: First Department of Internal Medicine, Kurume University School of Medicine, St. Maria Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Shiraishi
authors.forename: A
authors.initials: A
authors.lastname: Sakamoto
authors.forename: H
authors.initials: H
authors.lastname: Jojima
authors.forename: K
authors.initials: K
authors.lastname: Masuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Okubo
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Fuzimatsu
authors.forename: S
authors.initials: S
authors.lastname: Fukahori
authors.forename: S
authors.initials: S
authors.lastname: Osabe
authors.forename: Y
authors.initials: Y
authors.lastname: Imamura
authors.forename: J
authors.initials: J
authors.lastname: Honda
authors.forename: K
authors.initials: K
authors.lastname: Oizumi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011347:Procollagen / Q000097:blood*
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C023443:carboxyl-terminal parathyroid hormone; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D003094:Collagen