title: Arterio-venous ethanol levels in blood and plasma after intravenous injection in rabbits.
abstract: Arterio-venous ethanol concentrations in both whole blood and plasma were determined as a function of time in the rabbit. Following i.v. injection of 1.0 g/kg, both arterial and venous ethanol concentrations showed an abrupt decline occurring immediately after the end of the administration, followed by a pseudolinear phase that persisted for the length of the experiment. This work substantiates the arterio-venous ethanol concentration differences reported in the literature. It illustrates that equal arterial and venous ethanol concentrations may not be achieved readily after rapid i.v. injection. Moreover, it demonstrates a faster decay of ethanol concentrations in arterial than in venous plasma.
authors.affiliation: U.F.R. de Pharmacie, Laboratoire de Pharmacologie et de Pharmacocinétique, Reims, France. matthieu.kaltenbach@univ-reims.fr
authors.forename: M L
authors.initials: ML
authors.lastname: Kaltenbach
authors.forename: R
authors.initials: R
authors.lastname: Vistelle
authors.forename: G
authors.initials: G
authors.lastname: Hoizey
authors.forename: D
authors.initials: D
authors.lastname: Lamiable
authors.forename: L
authors.initials: L
authors.lastname: Zbierski
mesh_terms: D000818:Animals; D001158:Arteries; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood*; D007275:Injections, Intravenous; D008297:Male; D009994:Osmolar Concentration; D010949:Plasma / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors; D014680:Veins
chemical_list: D000431:Ethanol