title: Age, gender, IOP, refraction and optic disc topography in normal eyes. A cross-sectional study using raster and scanning laser tomography.
abstract: OBJECTIVE
  To study the influence of age, gender, intraocular pressure and refraction on optic disc topography in normal subjects.
  
  
  METHODS
  We studied both eyes of 225 healthy subjects between 20 and 80 years of age using raster tomography (Glaucoma-Scope, Ophthalmic Imaging Systems, Sacramento CA, USA) and scanning laser tomography (Heidelberg Engineering, Heidelberg, Germany). We chose to study cup area and maximum cup depth, two variables that are minimally influenced by the operator.
  
  
  RESULTS
  Raster and scanning laser tomography results were strongly correlated. Cup area was independent of age, gender and refraction. It was weakly associated with IOP, but this association was significant only when the cup area was measured with scanning laser tomography. Maximum cup depth was independent of age, gender and IOP. It was larger in hypermetropic eyes, although this trend was significant only when maximum cup depth was measured with raster tomography.
  
  
  CONCLUSIONS
  Our results indicate that optic nerve head topography does not change significantly with age in normal subjects. This information has important implications for follow-up of pathological changes in optic nerve head topography.
authors.affiliation: Department of Ophthalmology, Malmö University Hospital, Sweden. kg.gundersen@oftal.mas.lu.se
authors.forename: K G
authors.initials: KG
authors.lastname: Gundersen
authors.forename: A
authors.initials: A
authors.lastname: Heijl
authors.forename: B
authors.initials: B
authors.lastname: Bengtsson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000033:anatomy & histology*; D012016:Reference Values; D012029:Refraction, Ocular / Q000502:physiology; D012727:Sex Characteristics; D014054:Tomography / Q000379:methods