title: The calcium store in the nuclear envelope.
abstract: The nuclear envelope has a relatively small volume, but is connected up to the vastly larger endoplasmic reticulum. The Ca2+ concentration in the lumen of the interconnected nuclear envelope and endoplasmic reticulum network is in the resting state maintained at a level of more than 100 microM. There are specific Ca2+ release channels present in the inner nuclear membrane that can be activated by inositol trisphosphate or cADP ribose. The system, therefore, allows selective release of Ca2+ into the nucleoplasm which could be important for the control of specific types of gene expression.
authors.affiliation: MRC Secretory Control Research Group, Physiological Laboratory, University of Liverpool, UK.
authors.forename: O H
authors.initials: OH
authors.lastname: Petersen
authors.forename: O V
authors.initials: OV
authors.lastname: Gerasimenko
authors.forename: J V
authors.initials: JV
authors.lastname: Gerasimenko
authors.forename: H
authors.initials: H
authors.lastname: Mogami
authors.forename: A V
authors.initials: AV
authors.lastname: Tepikin
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D009685:Nuclear Envelope / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D000252:Calcium-Transporting ATPases; D002118:Calcium