Solid phase synthesis of functionalized biaryl ethers: versatile scaffolds for combinatorial chemistry.
4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to react under mild conditions with a wide range of functionalized phenols to yield, after cleavage, the corresponding biaryl ethers in excellent purity. In a similar fashion, biaryl thioethers could be obtained. Further elaboration of immobilized biaryl ethers demonstrates the potential for combinatorial library generation.
Wijkmans
J C
JC
Oxford Diversity, A Division of Oxford Asymmetry Ltd., Abingdon, Oxon, UK.
Culshaw
A J
AJ
Baxter
A D
AD
D004987:Ethers / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009579:Nitrobenzoates / Q000378:metabolism; D010636:Phenols / Q000378:metabolism; D012116:Resins, Plant / Q000378:metabolism
D004987:Ethers; D009579:Nitrobenzoates; D010636:Phenols; D012116:Resins, Plant; C081549:4-fluoro-3-nitrobenzoic acid