title: Correlations between plasma-neuropeptides and temperament dimensions differ between suicidal patients and healthy controls.
abstract: BACKGROUND
  Decreased plasma levels of plasma-neuropeptide Y (NPY) and plasma-corticotropin releasing hormone (CRH), and increased levels of plasma delta-sleep inducing peptide (DSIP) in suicide attempters with mood disorders have previously been observed. This study was performed in order to further understand the clinical relevance of these findings.
  
  
  METHODS
  Examination of correlates between temperament dimensions (Karolinska Scales of Personality (KSP), the Eysenck Personality Questionnaire together with the IVE- impulsiveness scale (EPQI), and the Marke-Nyman Temperament (MNT)) and NPY, CRH and DSIP and serum-cortisol in the dexamethasone suppression test (DST) in 38 suicidal patients and matched controls.
  
  
  RESULTS
  NPY correlated significantly and positively with psychasthenia, irritability, and stability and significantly and negatively with validity in patients, but significantly and negatively with muscular tension, psychasthenia, verbal aggression and irritability in controls. DSIP correlated significantly and positively with impulsiveness (EPQI) in controls. CRH correlated negatively with lie in controls. Cortisol correlated significantly and positively with validity, extraversion and verbal aggression and significantly and negatively with inhibition of aggression in controls.
  
  
  CONCLUSIONS
  NPY may be related to stress tolerance. DSIP seems to be associated with impulsivity/antisocial traits.
  
  
  CONCLUSIONS
  Non-suicidal patients were not included in the examination.
  
  
  CONCLUSIONS
  The state of depression or stress seems to influence the correlations studied.
authors.affiliation: Department of Clinical Neuroscience, Lund University Hospital, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Westrin
authors.forename: G
authors.initials: G
authors.lastname: Engstöm
authors.forename: R
authors.initials: R
authors.lastname: Ekman
authors.forename: L
authors.initials: L
authors.lastname: Träskman-Bendz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003346:Corticotropin-Releasing Hormone / Q000097:blood; D003701:Delta Sleep-Inducing Peptide / Q000097:blood; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007175:Impulsive Behavior / Q000097:blood / Q000150:complications / Q000503:physiopathology; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood; D009479:Neuropeptides / Q000097:blood*; D009497:Neurotic Disorders / Q000097:blood / Q000150:complications / Q000503:physiopathology; D010556:Personality Tests; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D013406:Suicide, Attempted / Q000523:psychology; D013694:Temperament / Q000502:physiology*
chemical_list: D009478:Neuropeptide Y; D009479:Neuropeptides; D003701:Delta Sleep-Inducing Peptide; D003907:Dexamethasone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone