title: Neuronal responses across cortical field A1 in plasticity induced by peripheral auditory organ damage.
abstract: The adult auditory cortex is capable of a plastic reorganization of its tonotopic map after damage to restricted parts of the cochlear sensory epithelium. We examine the precise conditions of cochlear damage required to demonstrate such plasticity in the primary auditory cortex (A1) of the cat and the changes observed in neuronal responses in the A1 which has reorganized in plasticity of the tonotopic map. From these data we attempt to predict the conditions required for similar plasticity to occur in humans after cochlear damage.
authors.affiliation: Department of Physiology, Monash University, Clayton, Australia. ramesh.rajan@med.monash.edu.au
authors.forename: R
authors.initials: R
authors.lastname: Rajan
authors.forename: D R
authors.initials: DR
authors.lastname: Irvine
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D001309:Auditory Threshold; D002415:Cats; D003051:Cochlea / Q000473:pathology* / Q000503:physiopathology*; D034381:Hearing Loss / Q000473:pathology / Q000503:physiopathology; D006314:Hearing Loss, Conductive / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*