Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents.
Programmed ribosomal frameshifting is used by many viruses to regulate the production of structural and enzymatic proteins. Altering the frameshifting efficiencies disrupts the virus life cycle and eliminates or reduces virus production. Ribosomal frameshifting therefore provides a unique target on which antiviral agents can function. This article describes a series of rapid assay strategies that have been developed and used to identify potential antiviral agents that target programmed -1 ribosomal frameshifting.
Dinman
J D
JD
Department of Molecular Genetics and Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854, USA.
Ruiz-Echevarria
M J
MJ
Peltz
S W
SW
D000998:Antiviral Agents / Q000494:pharmacology*; D018965:Frameshifting, Ribosomal; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000187:drug effects*
D000998:Antiviral Agents