Synthesis and cytotoxicity of the three-membered aromatic pyrimidine derivatives.
A series of the three-membered aromatic anthracene, acridine, carbazole substituted with pyrimidine moiety equipped with pharmacophoric chain of N'-(2'-hydroxyethyl)ethylenediamine or dialkylamino-3-propylamine was obtained and tested for the cytotoxic properties in SRB test. The synthesis was performed from 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-thio-5-pyrimidinecarboxylic acid or its ethyl ester and three-membered aromatic amines (e.g. 9-aminoacridine). Some of the compounds showed significant cytotoxic activity.
Długosz
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Department of Toxicology, University of Medicine, Wrocław, Poland.
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008163:Luminescent Measurements; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011743:Pyrimidines