title: Dragmacidins: new protein phosphatase inhibitors from a southern australian deep-water marine sponge, spongosorites sp
abstract: A Spongosorites sp. collected during trawling operations off the southern coast of Australia returned the new alkaloid dragmacidin E (3), the structure of which was secured by detailed spectroscopic analysis. Dragmacidin E (3), and its co-metabolite dragmacidin D (1) have been identified as potent inhibitors of serine-threonine protein phosphatases.
authors.affiliation: Department of Chemistry, University of Melbourne, Parkville, Victoria 3052, Australia, Faculty of Medicine, The University of Newcastle, University Drive, Callaghan, New South Wales 2308, Australia, and Queensland Pharmaceutical Resea.
authors.initials: RJ
authors.lastname: Capon
authors.initials: F
authors.lastname: Rooney
authors.initials: LM
authors.lastname: Murray
authors.initials: E
authors.lastname: Collins
authors.initials: ATR
authors.lastname: Sim
authors.initials: JAP
authors.lastname: Rostas
authors.initials: MS
authors.lastname: Butler
authors.initials: AR
authors.lastname: Carroll