title: [Ethanol inhibits recombination in somatic cells of gamma-irradiated larvae of Drosophila melanogaster].
abstract: Raising of gamma-irradiated larvae of Drosophila melanogaster on an ethanol-containing medium resulted in decreased mutation frequency in the wing somatic mutation and recombination test. This decrease in mutagenicity was mainly caused by the reduced recombination frequency. In lines with high activity of cytochrome P450, ethanol did not exhibit the radioprotective effect. Frequency of spontaneous mutations was significantly different in reciprocal crosses, whereas frequency of induced somatic mutations did not depend on the cross direction. Addition of 10% ethanol to the medium did not affect spontaneous mutation frequency.
authors.affiliation: Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: L P
authors.initials: LP
authors.lastname: Zakharenko
authors.forename: I K
authors.initials: IK
authors.lastname: Zakharov
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000166:cytology / Q000187:drug effects* / Q000235:genetics; D000431:Ethanol / Q000494:pharmacology*; D005720:Gamma Rays; D005838:Genotype; D007814:Larva / Q000166:cytology / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects* / Q000235:genetics; D016296:Mutagenesis / Q000187:drug effects*; D011995:Recombination, Genetic / Q000187:drug effects*
chemical_list: D000431:Ethanol
vernacular_title: Etanol inigibiruet rekombinatsiiu v somaticheskikh kletkakh gamma-obluchennykh lichinok.