Voila, a new Drosophila courtship variant that affects the nervous system: behavioral, neural, and genetic characterization.
In Drosophila melanogaster, a specific PGAL4 transposon induces the Voila1 genetic variant and produces multiple phenotypes. Homozygous Voila1/1 flies rarely reach adulthood, whereas heterozygous Voila1/+ adult males show strong bisexual behavior. Males with a single copy of Voila1 driving the feminizing transgene UAS-transformer show very reduced sexual activity but no overall effect on their behavior. Voila1 is specifically expressed in the nervous system. In the CNS, it is expressed mainly in the mushroom bodies and, to a lesser extent, in the antennal lobes. In the peripheral nervous system, GAL4 expression is almost entirely restricted to the gustatory sensilla. Using chromosomal deficiencies, the behavioral alteration was genetically mapped to the same location as the PGAL4 element (86E1-2). The multiple behavioral effects of the Voila genetic variant are discussed in light of its expression in the nervous system and its genetic basis.
Balakireva
M
M
Unité de Recherche Associée Centre National de la Recherche Scientifique 1491, Université Paris-Sud, 91405 Orsay-Cedex, France.
Stocker
R F
RF
Gendre
N
N
Ferveur
J F
JF
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D002874:Chromosome Mapping; D002875:Chromosomes; D003380:Courtship; D004251:DNA Transposable Elements / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics*; D005121:Extremities; D005260:Female; D017952:Ganglia, Invertebrate / Q000737:chemistry; D015870:Gene Expression / Q000502:physiology; D017344:Genes, Insect / Q000502:physiology*; D007763:Lac Operon; D008297:Male; D017933:Peripheral Nervous System / Q000737:chemistry; D010675:Pheromones / Q000502:physiology; D019849:Sex Determination Processes; D014921:Wings, Animal
D004251:DNA Transposable Elements; D010675:Pheromones