Fish oil given by gavage increases lymphocyte proliferation and production of hydrogen peroxide by rat macrophages.
1. The effect of fish oil (FO) administration by gavage (0.4% body weight) on macrophage and lymphocyte function was investigated in young male rats. The results were compared with those obtained by administration of soybean oil (SB) and cocoa butter (CB). 2. Lymphocyte proliferation was markedly increased by FO administration compared with control and other oils. 3. Macrophage phagocytosis capacity was not affected by FO, but it was increased by CB and SB. 4. The oils did not affect the production of O2.- but increased the production of H2O2 in the presence of PMA. 5. The administration of the oils did not markedly affect the activity of antioxidant enzymes in macrophages, except for a decrease in superoxide dismutase activity by FO.
Miyasaka
C K
CK
Department of Nutrition and Food Sciences, Faculty of Pharmaceutical Sciences, University of São Paulo, Brazil.
Souza
J A
JA
de Melo
M P
MP
Curi
T C
TC
Lajolo
F M
FM
Curi
R
R
D000818:Animals; D002374:Catalase / Q000097:blood; D002455:Cell Division / Q000187:drug effects; D004041:Dietary Fats / Q000494:pharmacology; D005395:Fish Oils / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007441:Intubation, Gastrointestinal; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D051381:Rats; D013024:Soybean Oil / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000097:blood
D004041:Dietary Fats; D005395:Fish Oils; C052387:cocoa butter; D013024:Soybean Oil; D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase