Effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast.
The inhibitory effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast in vitro was compared to that of all-trans-retinoic acid. The proliferation of fibroblasts was inhibited by both retinoids at the concentration of 1 microM after 5 days of culture. Synthesis of DNA and collagen was inhibited by both retinoids concentration-dependently up to 10 microM, although tazarotene was weaker in the inhibition of collagen synthesis. These results suggest the possible usefulness of tazarotene in the treatment of fibrotic diseases.
Ogawa
A
A
Department of Pharmacology, Tokyo Women's Medical University, Japan.
Maeguchi
M
M
Uchida
Y
Y
Yoshioka
T
T
Kawashima
M
M
Muraki
T
T
D001973:Bromodeoxyuridine / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis; D003879:Dermatologic Agents / Q000378:metabolism / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D009539:Nicotinic Acids / Q000378:metabolism / Q000494:pharmacology*; D018168:Receptors, Retinoic Acid / Q000145:classification / Q000187:drug effects / Q000378:metabolism; D012176:Retinoids / Q000378:metabolism / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology
D003879:Dermatologic Agents; D009539:Nicotinic Acids; D018168:Receptors, Retinoic Acid; D012176:Retinoids; D014212:Tretinoin; C086827:tazarotene; D003094:Collagen; D004247:DNA; D001973:Bromodeoxyuridine