Intracellular calcium signaling systems in the pathophysiology of affective disorders.
In this paper, we show the importance of intracellular calcium (Ca2+) signaling systems in the pathophysiology of mood disorders based on our recent work. Patients with affective disorders appear to have an enhanced intracellular Ca2+ rise in response to serotonin. We have observed effects of antidepressant drugs on intracellular Ca2+ signaling in rat cultured neuronal cells and glioma cells, and found that acute application of several classes of antidepressant drugs inhibited intracellular Ca2+ signaling and Ca2+-related signaling. It is important to investigate the role of intracellular Ca2+ signaling system for an understanding of the pathophysiology of affective disorders.
Yamawaki
S
S
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Japan.
Kagaya
A
A
Tawara
Y
Y
Inagaki
M
M
D000341:Affective Disorders, Psychotic / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D002118:Calcium / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D002997:Clomipramine / Q000494:pharmacology; D006801:Humans; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D015398:Signal Transduction / Q000502:physiology*
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D002118:Calcium; D002997:Clomipramine; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors