title: Immediate-type heat urticaria: report of a case and study of plasma histamine release.
abstract: We report a 68-year-old man who had immediate-type heat urticaria with systemic symptoms. Immersing his hand in water at 42 degrees C (heat challenge test) produced an urticarial response, with an increase in the plasma histamine level from 0.26 to 7.64 ng/mL. Administration of oral antihistamines alone did not suppress either the urticarial response or the increase in plasma histamine. However, a combination of antihistamines and desensitization improved the skin lesions and reduced the plasma histamine level. The heat challenge test subsequently provoked a negative response and there was no increase in plasma histamine level 3 months after starting the combination therapy. These results indicate that the histamine level reflected the result of the heat challenge test and the amelioration of the skin eruption.
authors.affiliation: Department of Dermatology, Hirosaki University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Baba
authors.forename: K
authors.initials: K
authors.lastname: Nomura
authors.forename: K
authors.initials: K
authors.lastname: Hanada
authors.forename: I
authors.initials: I
authors.lastname: Hashimoto
mesh_terms: D000368:Aged; D006229:Hand Dermatoses / Q000097:blood / Q000209:etiology* / Q000628:therapy; D006632:Histamine / Q000097:blood; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000209:etiology* / Q000628:therapy; D008297:Male; D014581:Urticaria / Q000097:blood / Q000209:etiology* / Q000628:therapy
chemical_list: D006632:Histamine