title: Angiotensin converting enzyme (ACE) inhibitors from Jasminum azoricum and Jasminum grandiflorum.
abstract: Bioactivity-guided fractionation of extracts of the aerial parts of Jasminum azoricum var. travancorense, using an in vitro ACE inhibition assay, led to isolation of three oligomeric, iridoid-type compounds, which were named sambacein I-III. Their structures are based on spectroscopic and chemical evidence. Similarly, fractionation of extracts of aerial parts of J. grandiflorum resulted in the isolation of the previously reported ACE inhibitor, oleacein. The IC50 values of purified ACE inhibitors were 26-36 microM. Moreover, 2-(3,4-dihydroxyphenyl)-ethanol, isoquercitrin and ursolic acid were isolated from J. grandiflorum. Sambaceins and oleacein are formed from genuine iridoid glucosides during processing of the plant material. NMR spectroscopy was used to measure the level of the ACE inhibitors in the traditional medicines prepared in Kerala from these Jasminum species.
authors.affiliation: Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Somanadhan
authors.forename: U W
authors.initials: UW
authors.lastname: Smitt
authors.forename: V
authors.initials: V
authors.lastname: George
authors.forename: P
authors.initials: P
authors.lastname: Pushpangadan
authors.forename: S
authors.initials: S
authors.lastname: Rajasekharan
authors.forename: J O
authors.initials: JO
authors.lastname: Duus
authors.forename: U
authors.initials: U
authors.lastname: Nyman
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
authors.forename: J W
authors.initials: JW
authors.lastname: Jaroszewski
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D010936:Plant Extracts