title: [Alkyl nitrosoureidodioxans and alkyl nitrosoureidopropane diols -- new groups of antitumor compounds].
abstract: 1,3-dioxan- and 1,3-propane diol derivatives of alkyl nitrosourea have been synthesized and studied. Like other 2/chloroethylnitrosoureas, they exerted pronounced influence on a wide range of transplantable tumors, including those transplanted intracranially. Antitumor effect was found to depend on C5 and C2 atom substituent in the 1,3-dioxan cycle and 1,3-propane diol, respectively. The therapeutic effect and toxicity of 1,3-propane diol derivatives were higher than those of 1,3-dioxan. The substances lost all antitumor properties if a methyl group was substituted for the 2-chloroethyl one, even though a nitroso group was retained in their structure.
authors.affiliation: N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
authors.forename: S A
authors.initials: SA
authors.lastname: Kon'kov
authors.forename: A N
authors.initials: AN
authors.lastname: Stukov
authors.forename: V V
authors.initials: VV
authors.lastname: Reztsova
authors.forename: I M
authors.initials: IM
authors.lastname: Krylova
authors.forename: B A
authors.initials: BA
authors.lastname: Ivin
authors.lastname: VA Filov
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004146:Dioxanes / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology*; D051381:Rats; D016019:Survival Analysis
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D004146:Dioxanes; D009607:Nitrosourea Compounds; D011409:Propylene Glycols
vernacular_title: Alkilnitrozoureidodioksany i alkilnitrozoureidopropandioly -- novye gruppy protivoopukholevykh soedineniĭ.