Total body irradiation-induced osteochondromata.
Nine patients developed osteochondromata, a mean of 6 years after total body irradiation (TBI) given before bone marrow transplantation for childhood leukaemia. This represents 23% of patients receiving TBI during the period from 1981 to 1989 surviving > or =5 years after bone marrow transplantation. The patients were followed up for a mean of 12.5 years from diagnosis of leukaemia and a mean of 2.5 years from diagnosis of osteochondromata. No osteochondroma, including three lesions removed surgically, showed evidence of malignant change. Six patients received growth hormone for irradiation-induced growth hormone deficiency, but this did not appear to influence the natural history of the osteochondromata. Radiation-induced osteochondromata (RIO) are often multiple and are indistinguishable from the more common idiopathic type. The incidence of RIO after TBI was higher than that reported after local irradiation.
Harper
G D
GD
Department of Radiology and Haematology/Oncology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
Dicks-Mireaux
C
C
Leiper
A D
AD
D016026:Bone Marrow Transplantation; D001859:Bone Neoplasms / Q000209:etiology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000628:therapy; D008297:Male; D009381:Neoplasms, Radiation-Induced; D018216:Osteochondromatosis / Q000209:etiology* / Q000601:surgery; D019172:Transplantation Conditioning / Q000009:adverse effects; D014916:Whole-Body Irradiation / Q000009:adverse effects*