Synthesis of oligodeoxyribonucleotide containing novel C-5 reactive 2'-deoxyuridine derivative and its functional modification via post-synthetic technique.
2'-Deoxyuridine derivatives bearing an activated ester at C-5 position were synthesized and was examined their use for the preparation of modified oligodeoxyribonucleotides (ODNs) by a post-modification method. The ODNs containing cyanomethyl ester at C-5 position of the deoxyuridine residue reacted easily with a primary amine of several functional molecules under the mild condition to give the corresponding modified ODNs.
Kohgo
S
S
Department of Chemistry, Faculty of Engineering, Gunma University, Japan.
Umeda
A
A
Ozaki
H
H
Shinozuka
K
K
Sawai
H
H
D001483:Base Sequence; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D003857:Deoxyuridine