[The mechanisms of the hepatotoxic action of the antitumor preparation vepesid].
It was shown in experiments on rats that intravenous infusion of the antitumor drug vepesid in a maximum tolerated dose causes stimulation of free-radical oxidation and changes in the fractional composition of lipids and phospholipids in the hepatic tissue. Changes in the activity of aminotransferases and alkaline phosphatase in the blood were recorded.
Vetoshkina
T V
TV
Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
Dubskaia
T Iu
TIu
Timina
E A
EA
Gol'dberg
V E
VE
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000633:toxicity*; D005047:Etoposide / Q000008:administration & dosage / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000032:analysis / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012545:Schiff Bases; D013997:Time Factors
D000972:Antineoplastic Agents, Phytogenic; D008054:Lipid Peroxides; D010743:Phospholipids; D012545:Schiff Bases; D005047:Etoposide
Mekhanizmy gepatotoksicheskogo deĭstviia protivoopukholevogo preparata vepezida.