title: Spatio-temporal and kinematic analysis of pointing movements performed by cerebellar patients with limb ataxia.
abstract: Three patients with cerebellar limb ataxia and three age-matched controls performed arm-pointing movements towards a visual stimulus during an experimental procedure using a double-step paradigm in a three-dimensional space. Four types of trajectories were defined: P1, single-step pointing movement towards the visual stimulus in the initial position S1; P2, double-step pointing movement towards S1; P3, double-step straight pointing movement towards the second position S2; and P4, double-step pointing movement towards S2 with an initial direction towards S1. We found that the cerebellar patients, as well as the controls, were able to modify their motor programs, but with impaired timing, severe anomalies in the direction and amplitude of the changed movement trajectories and alteration of the precision of the pointing movements.
authors.affiliation: Laboratoire de Neurobiologie Cellulaire et Fonctionnelle, Centre National de la Recherche Scientifique, Marseille, France.
authors.forename: B
authors.initials: B
authors.lastname: Bonnefoi-Kyriacou
authors.forename: E
authors.initials: E
authors.lastname: Legallet
authors.forename: R G
authors.initials: RG
authors.lastname: Lee
authors.forename: E
authors.initials: E
authors.lastname: Trouche
mesh_terms: D000328:Adult; D002524:Cerebellar Ataxia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000502:physiology