title: Poly(L-lysine)-graft-dextran copolymer is a novel stabilizer of triplex DNA(II): potassium-insensitive triplex formation.
abstract: Triple helix formation involving guanine-rich oligonucleotides is inhibited by physiological concentrations of potassium (K+). Using in vitro electrophoretic mobility shift assay (EMSA), we show that PLL-g-dex copolymer significantly stabilizes triplex structure at physiological levels of K+ that greatly inhibited triplex formation with a unmodified, guanine-rich oligonucleotide.
authors.affiliation: Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ferdous
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Maruyama
authors.forename: T
authors.initials: T
authors.lastname: Akaike
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D004355:Drug Stability; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry; D011188:Potassium
chemical_list: D003911:Dextrans; D009838:Oligodeoxyribonucleotides; C113090:poly(lysine)-graft-dextran; D011107:Polylysine; D004247:DNA; D011188:Potassium