title: [High-dose chemotherapy--a new hope for some patients with malignant tumors?].
abstract: High-dosage chemotherapy is at present a very intensively investigated therapeutic procedure which rises great expectations. Administration of large doses of cytostatics is made possible by subsequent transplantation of autologous or allogenic haematopoietic progenitor cells (transplantation of peripheral stem cells or bone marrow). This reduces markedly the haematological toxicity of chemotherapy and it is possible to administer cytostatics in amounts at the non-haematological toxicity borderline. In the first part of the paper theoretical principles of high-dosage chemotherapy are analyzed, the relationship between the dosage of the drug and its effect. The author describes also cytostatics used in regimens of high dosage chemotherapy and discusses general toxic effects of this treatment.
authors.affiliation: II. interní klinika FN, Brno Bohunice.
authors.forename: J
authors.initials: J
authors.lastname: Mayer
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Vysokodávkovaná chemoterapie--nová nadĕje pro nĕkteré nemocné se zhoubnými nádory?