title: Differing effects of two-week suspension on male and female mouse bone metabolism.
abstract: The effects of suspension on bone histomorphometry during the first and second week of tail suspension are compared for male and female mice of the common inbred strain, the C57BL/6J. In male mice, significant changes in bone formation rate (BFR) were largely confined to the endocortical perimeter. BFR along the endocortical mid-diaphysis in the femora of suspended male mice was reduced 54.1% and 55.6% for the first and second week, respectively. In female mice, however, measured metabolic changes due to suspension occurred along the periosteal perimeter, where there was a decrease in BFR of 58.3% for the first week and 60.9% for the second. The notable difference in the bone perimeter affected by suspension observed in male and female mice indicates a difference in the metabolic control of bone development in male and female C57BL/6J mice. More importantly, this may indicate a sex-based difference in preserving structural properties in the response of the skeleton to unloading.
authors.affiliation: University of Colorado, Boulder 80309, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Bateman
authors.forename: J J
authors.initials: JJ
authors.lastname: Broz
authors.forename: M L
authors.initials: ML
authors.lastname: Fleet
authors.forename: S J
authors.initials: SJ
authors.lastname: Simske
mesh_terms: D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D005269:Femur / Q000473:pathology; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008903:Minerals / Q000378:metabolism; D010012:Osteogenesis; D012727:Sex Characteristics
chemical_list: D008903:Minerals