title: Preprotachykinin-A gene expression in the forebrain of Sardinian alcohol-preferring and -nonpreferring rats.
abstract: Increasing evidence suggests that TKergic mechanisms might play a role in ethanol intake control. Preprotachykinin-A (PPT-A) mRNA brain levels were measured in Sardinian alcohol-preferring (sP) and Sardinian alcohol-nonpreferring (sNP) rats. PPT-A mRNAs were about 50% lower in sP than in sNP rats in the bed nucleus of the stria terminalis (BNST), whereas levels in the olfactory tubercle (Tu) were about 30% higher in sP than in sNP rats. Our findings suggest that altered PPT-A gene expression might contribute to the different ethanol preference and intake of sP opposite to sNP rats.
authors.affiliation: Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy. pompei@cambio.unicam.it
authors.forename: P
authors.initials: P
authors.lastname: Pompei
authors.forename: S
authors.initials: S
authors.lastname: Angeletti
authors.forename: R
authors.initials: R
authors.lastname: Ciccocioppo
authors.forename: G
authors.initials: G
authors.lastname: Colombo
authors.forename: G L
authors.initials: GL
authors.lastname: Gessa
authors.forename: M
authors.initials: M
authors.lastname: Massi
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics*; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D016548:Prosencephalon / Q000187:drug effects* / Q000378:metabolism*; D011498:Protein Precursors / Q000096:biosynthesis / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D015320:Tachykinins / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D011498:Protein Precursors; D015320:Tachykinins; C044206:preprotachykinin