title: Asbestos-related lung cancer mortality in Piedmont, Italy.
abstract: This study investigates the association between pleural neoplasm mortality, a possible proxy for asbestos exposure, and lung cancer mortality among males resident in Piedmont (northwestern Italy). Pleural neoplasm mortality was estimated in the 1,209 municipalities of the region for the period 1980-1992, applying Bayesian methods. The association with lung cancer mortality for municipalities was studied using Poisson regression. Urban/rural indicators and altitude were also included in the analysis. A positive, statistically significant association was found between pleural neoplasm and lung cancer mortality (beta = 0.025, P < 0.001); lung cancer risk was associated also with urban status (vs. rural, beta = 0.223, P < 0.001) and altitude (P = 0.01). The proportion of lung cancer deaths attributable to living in municipalities with increased pleural neoplasm mortality was 3.9% (95% confidence interval, 2.1-5.7%). The observed association and the presence of a dose-response relationship at the municipality level underscore the dangers of asbestos for human health.
authors.affiliation: International Agency for Research on Cancer, Lyon, France. martuzzi@iarc.fr
authors.forename: M
authors.initials: M
authors.lastname: Martuzzi
authors.forename: P
authors.initials: P
authors.lastname: Comba
authors.forename: M
authors.initials: M
authors.lastname: De Santis
authors.forename: I
authors.initials: I
authors.lastname: Iavarone
authors.forename: M
authors.initials: M
authors.lastname: Di Paola
authors.forename: M
authors.initials: M
authors.lastname: Mastrantonio
authors.forename: R
authors.initials: R
authors.lastname: Pirastu
mesh_terms: D000328:Adult; D000368:Aged; D000531:Altitude; D001195:Asbestosis / Q000401:mortality*; D001499:Bayes Theorem; D002423:Cause of Death; D016001:Confidence Intervals; D004781:Environmental Exposure / Q000009:adverse effects / Q000706:statistics & numerical data; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008175:Lung Neoplasms / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000401:mortality*; D016012:Poisson Distribution; D012306:Risk; D012424:Rural Population / Q000706:statistics & numerical data; D014505:Urban Population / Q000706:statistics & numerical data