title: Selenium levels, thiobarbituric acid-reactive substance concentrations and glutathione peroxidase activity in the blood of women with gestosis and imminent premature labour.
abstract: The aim of the study was to investigate antioxidant status, monitored by selenium and thiobarbituric acid-reactive substance concentrations in blood plasma, and glutathione peroxidase activity in erythrocytes and blood plasma in women with gestosis (n = 26), imminent premature labour (n = 48) and normal pregnancy (n = 23) during 19-38 weeks of pregnancy. Selenium concentrations in blood plasma were significantly higher in women with pathological pregnancies than in normal (45.5 +/- 10.5 micrograms l-1, p < 0.01 and 44.1 +/- 11.6 micrograms l-1, p < 0.05 vs. 38.6 +/- 8.3 micrograms l-1, respectively). In all groups of pregnant women Se concentrations were extremely low as compared with non-pregnant females. Glutathione peroxidase (GSH-Px) activity in blood plasma was significantly higher in complicated pregnancies than in healthy ones. There were no significant differences in thiobarbituric acid-reactive substance concentrations between all groups of pregnant women. Statistically significant correlations were found between blood plasma Se concentrations and GSH-Px activity in healthy pregnant (r = 0.53, p < 0.01), imminent premature labour (r = 0.39, p < 0.01), and non-pregnant females (r = 0.56, p < 0.001).
authors.affiliation: Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Gromadzinska
authors.forename: W
authors.initials: W
authors.lastname: Wasowicz
authors.forename: G
authors.initials: G
authors.lastname: Krasomski
authors.forename: D
authors.initials: D
authors.lastname: Broniarczyk
authors.forename: M
authors.initials: M
authors.lastname: Andrijewski
authors.forename: K
authors.initials: K
authors.lastname: Rydzynski
authors.forename: P
authors.initials: P
authors.lastname: Wolkanin
mesh_terms: D000328:Adult; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007752:Obstetric Labor, Premature / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012643:Selenium / Q000097:blood*
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium