title: Distal small bowel hormones: correlation with fasting antroduodenal motility and gastric emptying.
abstract: The aim of the present study was to study the interdigestive motor complex (MMC), distal small intestinal hormones, and gastric emptying in normal-weight and obese subjects before and after jejunoileal bypass (JIB). Therefore, fasting antroduodenal motility, gastric emptying, and RIA for motilin (MOT), neurotensin (NT), peptide YY (PYY), and glucagon-like peptide-1 (GLP-1) was performed in nine obese subjects before (BMI 42 +/- 4 kg/m2) and nine months after (BMI 31 +/- 4) JIB, and in two groups of nine age- and sex-matched controls (BMI 23 +/- 1 and 21 +/- 1). The rate of gastric emptying was faster in obese subjects and GLP-1 lower compared to normal-weight controls. After JIB, fewer phase III of the MMC were observed; fasting levels of PYY were elevated during the MMC; postprandial levels of NT, PYY, and GLP-1 were elevated; and gastric emptying was delayed. Our results suggest that there may be an association between an impaired GLP-1 response after food intake and obesity, and after JIB, PYY seems to regulate interdigestive motility while GLP-1 may regulate early gastric emptying.
authors.affiliation: Department of Surgery, Karolinska Institute at Danderyd Hospital, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Näslund
authors.forename: P
authors.initials: P
authors.lastname: Grybäck
authors.forename: L
authors.initials: L
authors.lastname: Backman
authors.forename: H
authors.initials: H
authors.lastname: Jacobsson
authors.forename: J J
authors.initials: JJ
authors.lastname: Holst
authors.forename: E
authors.initials: E
authors.lastname: Theodorsson
authors.forename: P M
authors.initials: PM
authors.lastname: Hellström
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005746:Gastric Emptying; D005768:Gastrointestinal Hormones / Q000097:blood / Q000502:physiology*; D005769:Gastrointestinal Motility; D052216:Glucagon-Like Peptide 1; D006801:Humans; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D009767:Obesity, Morbid / Q000503:physiopathology*; D010455:Peptides / Q000097:blood / Q000502:physiology; D019518:Postprandial Period
chemical_list: D005768:Gastrointestinal Hormones; D010455:Peptides; D052216:Glucagon-Like Peptide 1