title: The use of high-throughput synthesis and purification in the preparation of a directed library of adrenergic agents.
abstract: A library of potential agonists and antagonists for adrenergic receptors was prepared using high-throughput solution-phase parallel synthesis. Traditional solution-phase reductive amination reactions followed by rapid purification by ion exchange chromatography yielded products with near-analytical purity. An array of ketones and amines, arranged in an 8 x 12 matrix, were combined to form 96 individual compounds.
authors.affiliation: Research Technology & Proteins, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Siegel
authors.forename: A J
authors.initials: AJ
authors.lastname: Shuker
authors.forename: C A
authors.initials: CA
authors.lastname: Droste
authors.forename: P J
authors.initials: PJ
authors.lastname: Hahn
authors.forename: C D
authors.initials: CD
authors.lastname: Jesudason
authors.forename: J H
authors.initials: JH
authors.lastname: McDonald
authors.forename: D P
authors.initials: DP
authors.lastname: Matthews
authors.forename: C J
authors.initials: CJ
authors.lastname: Rito
authors.forename: A J
authors.initials: AJ
authors.lastname: Thorpe
mesh_terms: D000322:Adrenergic Agonists / Q000138:chemical synthesis*; D018674:Adrenergic Antagonists / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry; D002852:Chromatography, Ion Exchange; D004983:Ethanolamines / Q000138:chemical synthesis; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D011941:Receptors, Adrenergic / Q000378:metabolism
chemical_list: D000322:Adrenergic Agonists; D018674:Adrenergic Antagonists; D000588:Amines; D004983:Ethanolamines; D007659:Ketones; D011941:Receptors, Adrenergic