title: Synthesis and antitumor activities of some 4,5-dihydro-1H-1,2,4-triazol-5-ones.
abstract: Eight new 3-alkyl(aryl)-4-arylidenamino-4,5-dihydro-1H-1,2,4-triazol-5 - ones were synthesized and characterised by elemental analysis. 1H NMR, IR and UV spectra. Seven new and 34 recently reported derivatives of 4,5-dihydro-1H-1,2,4 triazol-5-one ring were screened for their antitumor activities.
authors.affiliation: Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: A A
authors.initials: AA
authors.lastname: Ikizler
authors.forename: A
authors.initials: A
authors.lastname: Ikizler
authors.forename: M
authors.initials: M
authors.lastname: Serdar
authors.forename: N
authors.initials: N
authors.lastname: Yildirim
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C112392:4,5-dihydro-1H-1,2,4-triazol-5-one; D000970:Antineoplastic Agents; D014230:Triazoles