XY gonadal dysgenesis in an adolescent with chronic renal failure: a case of Frasier syndrome.
OBJECTIVE
To report a case of XY gonadal dysgenesis in an adolescent with renal failure and to review the literature on this association.


METHODS
In this case report from the Tertiary Care University Medical Center, a 16-year-old female with chronic renal failure presenting with primary amenorrhea was studied. Interventions included laparotomy with bilateral gonadectomy and hormone replacement therapy.


METHODS
Karyotype, gonadal histology.


RESULTS
Diagnosis of gonadal dysgenesis. Presence of a gonadoblastoma.


CONCLUSIONS
Gonadal dysgenesis should be considered in any female adolescent with renal disease presenting with pubertal delay or primary amenorrhea.
Murray
S C
SC
Department of Obstetrics and Gynecology, University of Kentucky College of Medicine, Lexington 40536-0084, USA.
D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006059:Gonadal Dysgenesis / Q000150:complications / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D013577:Syndrome