Selective brain cooling in hyperthermia: the mechanisms and medical implications.
We hypothesize that selective brain cooling (SBC) can occur in hyperthermic humans despite the fact that humans have no carotid rete, a vascular structure that facilitates countercurrent heat exchange and that is located at the base of the skull in some mammals. We postulate that an increase in emissary and angular ocular venous flows contributes to SBC. The efficiency of SBC is increased by evaporation of sweat on the head and by ventilation through the nose. A body position that increases the intravenous pressure gradient across the skull increases emissary flows and hence enhances the efficiency of SBC. The validity of using tympanic temperature as an index of brain temperature is also postulated.
Nagasaka
T
T
Department of Physiology, School of Medicine, Kanazawa University, Ishikawa, Japan. tetsuo@med.kanazawa-u.ac.jp
Brinnel
H
H
Hales
J R
JR
Ogawa
T
T
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005334:Fever / Q000503:physiopathology*; D006736:Horses; D006801:Humans; D008954:Models, Biological; D012393:Rosacea / Q000503:physiopathology; D014432:Tympanic Membrane / Q000503:physiopathology