Labeling of calcitonin gene-related peptide and substance P increases in subnucleus caudalis of rabbit during maxillary sinusitis.
Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-like immunoreactivity (SP-LI) were evaluated in subnucleus caudalis following induction of sinusitis. Three days after induction, intensity of labeling for CGRP-LI and SP-LI increased in ipsilateral subnucleus caudalis. Labeling for CGRP-LI and SP-LI appeared normal at later time points (20 and 28 days). Early changes in these neuropeptides may contribute to the inflammatory process and painful symptoms accompanying sinusitis.
Roche
A K
AK
Department of Pharmacology, University of Minnesota, Minneapolis, USA.
Koutlas
I G
IG
Kajander
K C
KC
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D007150:Immunohistochemistry; D008297:Male; D015523:Maxillary Sinusitis / Q000378:metabolism*; D011817:Rabbits; D013373:Substance P / Q000032:analysis*; D014279:Trigeminal Nucleus, Spinal / Q000378:metabolism*
D013373:Substance P; D015740:Calcitonin Gene-Related Peptide