Production of monocyte chemoattractant protein 1 in tuberculosis patients.
To investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the immune response to Mycobacterium tuberculosis, we studied MCP-1 production in tuberculosis patients. CD14+ blood monocytes from tuberculosis patients spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14+ monocytes from healthy tuberculin reactors. MCP-1 production in lymph nodes from tuberculosis patients was also markedly increased. These findings suggest that MCP-1 can contribute to the antimycobacterial inflammatory response by attracting monocytes and T lymphocytes.
Lin
Y
Y
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.
Gong
J
J
Zhang
M
M
Xue
W
W
Barnes
P F
PF
D018932:Chemokine CCL2 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D018950:Lipopolysaccharide Receptors / Q000032:analysis; D009000:Monocytes / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000378:metabolism
D018932:Chemokine CCL2; D018950:Lipopolysaccharide Receptors; D012333:RNA, Messenger