title: Mechanical thrombolysis of acute occlusion of both the superficial and the deep femoral arteries using a thrombectomy device.
abstract: OBJECTIVE
  Our objective was to evaluate the efficacy of the Amplatz thrombectomy device for recanalization of acute occlusions of both the superficial and the deep femoral arteries.
  
  
  METHODS
  Eighteen patients with acute occlusions of the femoral arteries (eight male, 10 female; 10-87 years old) were treated using the Amplatz thrombectomy clot macerator. The duration of occlusion was 16 +/- 8 hr. Eighteen patients underwent treatment of the deep femoral artery, and 16 patients had additional involvement of the superficial femoral artery. After primary recanalization of the deep femoral artery, the superficial femoral artery was also recanalized using the Amplatz thrombectomy device. Nine patients required additional aspiration thrombectomy of the tibial arteries, five patients required additional aspiration thrombectomy of side branches of the deep femoral artery, and 12 patients required additional local thrombolysis with urokinase.
  
  
  RESULTS
  In 14 (78%) of 18 patients, recanalization of the deep femoral artery was complete without demonstrable residual thrombi. Arterial spasms were observed in five patients (28%). The rate of limb salvage was 94% at a mean follow-up interval of 8.9 +/- 4.1 months. In the 18 patients, the ankle-brachial pressure index went from a median value of 0.56 before therapy to a median value of 0.91 after therapy. No severe complications occurred.
  
  
  CONCLUSIONS
  Mechanical thrombolysis in the deep femoral artery with the Amplatz thrombectomy device is an effective, rapid method of treatment and is rarely associated with complications. In cases of concomitant occlusion of the tibial arteries, recanalization should always be attempted because the deep femoral artery may provide a functionally decisive collateral artery between the iliac and tibial vasculature.
authors.affiliation: Department of Radiology, University of Ulm, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Görich
authors.forename: N
authors.initials: N
authors.lastname: Rilinger
authors.forename: R
authors.initials: R
authors.lastname: Sokiranski
authors.forename: S
authors.initials: S
authors.lastname: Krämer
authors.forename: V
authors.initials: V
authors.lastname: Mickley
authors.forename: A
authors.initials: A
authors.lastname: Schütz
authors.forename: H J
authors.initials: HJ
authors.lastname: Brambs
authors.forename: R
authors.initials: R
authors.lastname: Pamler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D001794:Blood Pressure / Q000502:physiology; D001916:Brachial Artery / Q000502:physiology; D002648:Child; D003097:Collateral Circulation / Q000502:physiology; D003131:Combined Modality Therapy; D005260:Female; D005263:Femoral Artery / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007083:Iliac Artery / Q000503:physiopathology; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000627:therapeutic use; D011150:Popliteal Artery / Q000503:physiopathology / Q000601:surgery; D013396:Suction; D017131:Thrombectomy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D013923:Thromboembolism / Q000601:surgery*; D015912:Thrombolytic Therapy; D016909:Tibial Arteries / Q000503:physiopathology / Q000601:surgery; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use; D014661:Vasoconstriction / Q000502:physiology
chemical_list: D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator