Matrix-assisted laser desorption/ionization for short tandem repeat loci.
Matrix-assisted laser desorption/ionization was used for the detection of four base short tandem repeats (STR) for clinical samples using a time-of-flight mass spectrometer. Since STR plays an important role in genetic disease and human identification, this work indicates that laser desorption mass spectrometry has the potential to achieve rapid DNA typing for both forensic applications and genetic disease diagnosis.
Taranenko
N I
NI
Life Sciences Division, Oak Ridge National Laboratory, Tennessee 37831-6378, USA.
Golovlev
V V
VV
Allman
S L
SL
Taranenko
N V
NV
Chen
C H
CH
Hong
J
J
Chang
L Y
LY
D004247:DNA / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D008970:Molecular Weight; D009154:Mutation; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D004247:DNA