Improving the tumor specificity and retention of antibody-based molecules.
A number of novel strategies have been employed to enhance the degree and specificity of tumor-targeting by antibody-based molecules. These fall into three overlapping categories. The augmentation of the interaction between the antibody and target antigen (e.g., through increased affinity or valence), the enhancement of targeting specificity (e.g., by altering the clearance of unbound antibody or radiolabel), and the selection of radioisotopes and labeling methods which are more stable in vivo or better suited to the target application.
Adams
G P
GP
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. gadams@fccc.edu
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D016503:Drug Delivery Systems; D006801:Humans; D007553:Isotope Labeling; D009369:Neoplasms / Q000628:therapy*; D015202:Protein Engineering
D000911:Antibodies, Monoclonal