title: A novel transforming growth factor beta2 antisense transcript in mammalian lung.
abstract: Transforming growth factor (TGF) beta2 gene expression was examined in murine, rat and human lung by in situ hybridization with riboprobes. Hybridization signal was observed in a variety of cells with the sense probe, and Northern-blot analysis with this probe demonstrated the presence of a novel 3.5 kb transcript. This first report suggesting the existance of a natural TGFbeta2 antisense transcript raises the possibility that such a transcript may play a role in regulating TGFbeta2 production.
authors.affiliation: Centre for Cardiopulmonary Biochemistry and Respiratory Medicine, University College London Medical School, Rayne Institute, 5 University Street, London WC1E 6JJ, UK.
authors.forename: R K
authors.initials: RK
authors.lastname: Coker
authors.forename: G J
authors.initials: GJ
authors.lastname: Laurent
authors.forename: K
authors.initials: K
authors.lastname: Dabbagh
authors.forename: J
authors.initials: J
authors.lastname: Dawson
authors.forename: R J
authors.initials: RJ
authors.lastname: McAnulty
mesh_terms: D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D016372:RNA, Antisense / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: D016372:RNA, Antisense; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta