Effect of cisapride on myoelectrical activity of the gastrointestinal tract in the conscious miniature pig.
In conscious miniature pigs with electrodes implanted in the wall of the antrum pylori, duodenum, jejunum, ileum and caecum, the influence of intravenous injection of cisapride, 0.5 and 1 mg/kg, on gastrointestinal myoelectrical activity, was examined. Cisapride, 1 mg/kg, induced a delayed and sustained increase in antral myoelectrical activity. The studied intestinal segments were rather insensitive to the stimulating effect of the benzamide, since only the jejunum and the caecum revealed an increase in myoelectrical activity with the higher dose studied.
Wechsung
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E
Laboratory of Veterinary Physiology, University Centre of Antwerp, Belgium.
Houvenaghel
A
A
D000818:Animals; D002432:Cecum / Q000502:physiology; D020117:Cisapride; D003243:Consciousness; D004064:Digestive System / Q000187:drug effects; D004068:Digestive System Physiological Phenomena; D004576:Electromyography / Q000187:drug effects; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D007421:Intestine, Small / Q000502:physiology; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000502:physiology; D013552:Swine; D013556:Swine, Miniature
D005765:Gastrointestinal Agents; D010880:Piperidines; D020117:Cisapride