Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats.
The effects of one week of estrogen replacement on choline acetyltransferase (ChAT) and trkA mRNA expression are examined in young and aged rodents to determine whether estrogen continues to affect cholinergic neurons in aging brain. Significant increases in ChAT and trkA are observed in the nucleus basalis of Meynert (nBM) of both age groups. ChAT expression is also increased in the HDB without changes in trkA expression. Results indicate modulation of ChAT expression by estrogen is retained in the aged rodent brain and suggests the possibility that changes in ChAT expression may be dissociated from concurrent alterations in trkA.
Singer
C A
CA
Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
McMillan
P J
PJ
Dobie
D J
DJ
Dorsa
D M
DM
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002795:Choline O-Acetyltransferase / Q000235:genetics*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000235:genetics*; D010052:Ovariectomy; D016548:Prosencephalon / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D020917:Receptor, trkA
D002352:Carrier Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; D004958:Estradiol; D002795:Choline O-Acetyltransferase; D020917:Receptor, trkA