title: [Oral lesions in systemic lupus erythematosus. I. The etiopathogenic aspects of lupus erythematosus].
abstract: The authors investigate lupus erythematosus systemicus, characterized by the multiform etiology and autoimmune pathogenesis. Cutaneous lesions, large confluent areas of erythema, poikilodermatous lesions, atrophy and necrotizing vasculitis (leukocytoclastic vasculitis) occur in patients with lupus erythematosus (SLE). Ulcerative lesions are an ACR (American College of Rheumatology), (formerly ARA), criterion for the diagnosis of SLE. These lesions are suspected of being caused by a mechanism involving circulating immune complexes and neutrophils. This observation further supports previous evidence that all oral lesions in SLE result from vacuolar degeneration of basal keratinocytes. Immunopathologic study of lupus erythematosus shows the correlation between HLA-dr positive keratinocytes or Langerhans cells and epidermotropic T cells and the immunobiological significance of the antigen-antibody system in LES.
authors.affiliation: Corso di Laurea in Odontoiatria e Protesi Dentaria, Università degli Studi, Catania.
authors.forename: A
authors.initials: A
authors.lastname: Bonaccorso
authors.forename: T R
authors.initials: TR
authors.lastname: Tripi
mesh_terms: D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008297:Male; D009059:Mouth Diseases / Q000209:etiology* / Q000276:immunology
vernacular_title: Lesioni orali nel lupus eritematoso sistemico. Nota I: Aspetti etiopatogenetici del lupus eritematoso.