Age-related changes in the cerebrospinal fluid level of beta-endorphin and substance P. Short communication.
To evaluate the early age-related changes in neuropeptides, we have measured the cerebrospinal fluid (CSF) levels of beta-endorphin and substance P in young patients over a range of ages. Specimens of CSF were obtained from 39 neurologically normal children, aged 1 month to 10 years of age, and in 9 adult controls. CSF levels of both neuropeptides were observed to peak during the first year of life, and showed a negative correlation with increasing age. A significant positive correlation was observed between the CSF level of beta-endorphin and that of substance P.
Nagamitsu
S
S
Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume City, Japan.
Matsuishi
T
T
Komori
H
H
Yamashita
Y
Y
Eguchi
H
H
Ichikawa
K
K
Fujimoto
T
T
Kato
H
H
D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012016:Reference Values; D013373:Substance P / Q000134:cerebrospinal fluid*; D001615:beta-Endorphin / Q000134:cerebrospinal fluid*
D013373:Substance P; D001615:beta-Endorphin