[Tricalcium phosphate, vector of antibiotics: gentamycin and vancomycin. In vitro physicochemical characterization, study of biomaterial porosity and gentamycin and vancomycin elution].
We have investigated a Vancomycin and Gentamycin loaded macroporous tri-calcium phosphate-type beta-ceramic, Calciresorbr. Elution kinetics of Vancomycin and Gentamycin from spheric implants was studied by varying porosity and initial concentrations; then, the other following parameters, that can be modulated and are likely to be involved in this elution process, were analysed: Antibiotic charge: quantitative analysis (titration). qualitative analysis by scanning electron microscopy. Material's porosity: qualitative analysis: optical and scanning electron microscopy. quantitative analysis by stereology and treatment. This physicochemical characterization would favour correct manufacturing of new macroporous synthetic bioceramics in order to achieve satisfactory elution kinetics and homogenous materials.
Brouard
S
S
Laboratoire de Biomécanique et Biomatériaux, faculté de médecine, Rennes.
Lelan
J
J
Lancien
G
G
Bonnaure
M
M
Cormier
M
M
Langlais
F
F
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005839:Gentamicins / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D016062:Porosity; D014640:Vancomycin / Q000493:pharmacokinetics*
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D005839:Gentamicins; C485817:beta-tricalcium phosphate; D014640:Vancomycin; C018392:tricalcium phosphate
Phosphate tricalcique, vecteur d'antibiotiques: gentamicine et vancomycine. Caractérisation physicochimique in vitro, étude de la porosité du biomatériau et du relargage de la gentamicine et de la vancomycine.