title: A syndrome resembling idiopathic noncirrhotic portal hypertension in 4 young Doberman pinschers.
abstract: We describe 4 young male Doberman Pinschers (3 littermates and 1 unrelated dog) with a syndrome resembling idiopathic or noncirrhotic portal hypertension of humans. Each dog was evaluated for a hepatopathy resulting in portal hypertension, development of portosystemic collateral vessels, and hepatic encephalopathy. These dogs differ from previous reports of young dogs with hepatic insufficiency associated with portal hypertension and acquired portal systemic shunting by their lack of intrahepatic arteriovenous fistulae, portal vein atresia, or intrahepatic fibrosis. Clinicopathologic features included erythrocyte microcytosis, normal to mildly increased liver enzyme activities, increased concentrations of serum bile acids, reduced plasma indocyanine green clearance, and normal total bilirubin concentration. Abdominal ultrasonography disclosed a small liver and portosystemic collateral vessels. Radiographic imaging studies confirmed hepatofugal portal circulation and discounted hepatic arteriovenous fistulae. Histopathologic features in liver tissue from each dog were similar and consistent in all sections examined. Common findings included increased cross-sectional views of hepatic arterioles; hepatic lobular atrophy; scanty increase in connective tissue around some large portal triads; and absence of inflammation, disturbed lobular architecture, bile duct proliferation, or intrahepatic cholestasis.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA.
authors.forename: J
authors.initials: J
authors.lastname: DeMarco
authors.forename: S A
authors.initials: SA
authors.lastname: Center
authors.forename: N
authors.initials: N
authors.lastname: Dykes
authors.forename: A E
authors.initials: AE
authors.lastname: Yeager
authors.forename: B
authors.initials: B
authors.lastname: Kornreich
authors.forename: E
authors.initials: E
authors.lastname: Gschrey
authors.forename: K A
authors.initials: KA
authors.lastname: Credille
authors.forename: M
authors.initials: M
authors.lastname: Guffroy
authors.forename: F
authors.initials: F
authors.lastname: del Piero
authors.forename: B A
authors.initials: BA
authors.lastname: Valentine
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001921:Brain / Q000473:pathology; D004283:Dog Diseases; D004285:Dogs; D006801:Humans; D006975:Hypertension, Portal / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D011172:Portography; D011877:Radionuclide Imaging; D013577:Syndrome