Quantified distribution of serotonin transporter and receptors during the postnatal development of the rat barrel field cortex.
Serotonin membrane transporter and 5-HT1B and 5-HT2A receptors were visualized and measured by autoradiography in the rat barrel field cortex at postnatal days 4, 8, 12, 16 and in adult (> P60). [3H]citalopram binding, reflecting the presence of 5-HT transporter on thalamocortical fibers, produced a clearcut barrel pattern from P4 to P16 (peak at P8), and decreased to a dispersed, low density in the adult. The patterning and temporal profile of 5-HT1B receptor binding ([125I]cyanopindolol) followed a parallel course. The 5-HT2A receptor binding ([125I]DOI) also conformed transiently to a barrel pattern; it increased in density from P8 to P16 and returned to a level as low as at P4 in the adult. These data suggest that 5-HT exerts a dual role in the developing somatosensory cortex: a local regulation of the peripherally-induced activity of thalamocortical axons via 5-HT1B receptors, and a trophic-like influence mediated by 5-HT2A receptors and possibly involving BDNF.
Mansour-Robaey
S
S
Département de pathologie et biologie cellulaire, Université de Montréal, Québec, Canada.
Mechawar
N
N
Radja
F
F
Beaulieu
C
C
Descarries
L
L
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins; D013003:Somatosensory Cortex / Q000254:growth & development / Q000378:metabolism*; D014018:Tissue Distribution; D014738:Vibrissae / Q000294:innervation*
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D011985:Receptors, Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; C493232:Slc6a4 protein, rat