The effect of trimeric 2',5'-oligoadenylic acid and its epoxy-derivative on human immunodeficiency virus (HIV-1) reproduction and retroviruses reverse transcriptase activity.
The effect of trimeric 2',5'-oligoadenylic acid (2',5' A3) and its epoxy-derivative (2',5'-A2 (RAA) on human immunodeficiency virus (HIV-1) reproduction was studied. An HIV-1 infectivity titer decrease was shown on the model of limphoblastoid cells when the substances under study were used. The interferonogenic effect of both substances was discovered. 2',5'-A2 (RAA) inhibited the activity of retrovirus reverse transcriptase (a C-type).
Tkachuk ZYu
Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kiev.
Rybalko
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SL
Semernikova
L I
LI
Tkachuk
V V
VV
Zavelevich
M P
MP
Tkachuk
L V
LV
Eremenko
T
T
Mikhailopulo
I A
IA
Matsuka
G K
GK
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004794:Enzyme Repression; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D006801:Humans; D009843:Oligoribonucleotides / Q000494:pharmacology*; D012194:RNA-Directed DNA Polymerase / Q000187:drug effects*; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000187:drug effects
D000227:Adenine Nucleotides; D000998:Antiviral Agents; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D012194:RNA-Directed DNA Polymerase