title: Synthesis of the 2'-deoxy-2'-fluoro and 3'-deoxy-3'-fluoro analogues of 8-bromoadenosine.
abstract: After protection of the two sugar hydroxyl groups of 8-bromoadenosine, the products were converted to the arabinoside or xyloside, which were treated with diethy laminosulfur trifluoride (DAST) and acid to afford 2'-deoxy-2'-fluoro- or 3'-deoxy-3'-fluoro-8-bromoadenosine. 8-OH and 8-SH derivatives were obtained from 8-bromo congener.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Manabe
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D003839:Deoxyadenosines / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D007202:Indicators and Reagents; D015394:Molecular Structure
chemical_list: C113079:8-bromo-2'-deoxy-2'-fluoroadenosine; C113080:8-bromo-3'-deoxy-3'-fluoroadenosine; D003839:Deoxyadenosines; D007202:Indicators and Reagents; C036038:8-bromoadenosine; D000241:Adenosine