title: Cloning and sequence analysis of Hsp89alpha DeltaN, a new member of theHsp90 gene family.
abstract: We have identified a novel member of the Hsp90 gene family. This new gene, Hsp89alpha DeltaN, is remarkable in that it appears to represent a recent evolutionary event. Hsp89alpha DeltaN is identical in nucleotide sequence to Hsp89alpha for codons 224 to 732 (end). However, Hsp89alpha DeltaN cDNA lacks the ATP/geldanamycin binding domain (codons 1-220), instead containing 544 nucleotides of unique DNA at its 5' end including 30 novel codons.
authors.affiliation: Center for Molecular and Structural Biology, Hollings Cancer Center, Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29425, USA.
authors.forename: C W
authors.initials: CW
authors.lastname: Schweinfest
authors.forename: M W
authors.initials: MW
authors.lastname: Graber
authors.forename: K W
authors.initials: KW
authors.lastname: Henderson
authors.forename: T S
authors.initials: TS
authors.lastname: Papas
authors.forename: P L
authors.initials: PL
authors.lastname: Baron
authors.forename: D K
authors.initials: DK
authors.lastname: Watson
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D019143:Evolution, Molecular; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D016133:Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
chemical_list: D018841:HSP90 Heat-Shock Proteins; C112969:HSP90AA1 protein, human; D004247:DNA