title: Multifocal electroretinography in patients with Stargardt's macular dystrophy.
abstract: OBJECTIVE
  To describe the topography of multifocal electroretinograms (ERGs) and to explore its diagnostic value in patients with Stargardt's macular dystrophy (SMD).
  
  
  METHODS
  51 patients with SMD were examined by means of the m-sequence technique to characterise the topography of electroretinographic responses in the central visual field. The results were compared with data from 30 normal volunteers.
  
  
  RESULTS
  In 49 of 51 patients with SMD, macular electroretinographic activity was markedly diminished or non-detectable. Towards more peripheral areas, ERG responses of the SMD patients approached those of normals. Implicit times were not markedly delayed at any eccentricity.
  
  
  CONCLUSIONS
  In contrast with Ganzfeld electroretinography, multifocal electroretinography is useful to detect foveal dysfunction in SMD. Areas of dysfunction were found to be usually larger than expected from psychophysical measurements and morphological alteration. In early stages of the disease it was possible to detect foveal dysfunction, even in patients lacking morphological fundus changes and with good visual acuity.
authors.affiliation: University Eye Hospital, Department for Pathophysiology of Vision and Neuro-Ophthalmology, Tuebingen, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Kretschmann
authors.forename: M W
authors.initials: MW
authors.lastname: Seeliger
authors.forename: K
authors.initials: K
authors.lastname: Ruether
authors.forename: T
authors.initials: T
authors.lastname: Usui
authors.forename: E
authors.initials: E
authors.lastname: Apfelstedt-Sylla
authors.forename: E
authors.initials: E
authors.lastname: Zrenner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D004596:Electroretinography; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012607:Scotoma / Q000209:etiology; D018709:Statistics, Nonparametric; D014792:Visual Acuity