Hyperthermia in brain hemorrhage.
Hemorrhage in the midbrain and/or pons in patients is often associated with increased metabolism, resulting in hyperthermia. We have recently reported that hyperthermia develops in anesthetized rats following prepontine knife-cuts or procaine microinjections into the midbrain or upper pontine region. It was concluded that the hyperthermia in the animals was caused by the removal of a tonic inhibitor mechanism of heat production that exists in the lower midbrain. The present paper proposes a new hypothesis that the hyperthermia in patients with brainstem hemorrhage is caused by disinhibition of heat production due to the release of such a lower-midbrain mechanism.
Shibata
M
M
Department of Physiology and Yamanashi Institute of Environmental Sciences, Yamanashi Medical College, Nakakoma, Japan.
D002001:Adipose Tissue, Brown / Q000503:physiopathology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000503:physiopathology; D005334:Fever / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008636:Mesencephalon / Q000187:drug effects / Q000503:physiopathology; D008845:Microinjections; D008954:Models, Biological; D011149:Pons / Q000187:drug effects / Q000293:injuries / Q000503:physiopathology; D011343:Procaine / Q000008:administration & dosage; D051381:Rats
D011343:Procaine