Preparation of thietane derivatives from 2-(3-hydroxyalkylthio)benzoxazoles and their conversion into thietane nucleosides.
Thietanes were prepared by the reaction of 2-(3-hydroxyalkylthio)benzoxazoles with KH. 3,3-Dibenzylthietane was oxidized by mCPBA to give 3,3-dibenzylthietane-1-oxide, which was converted into thietane nucleosides (Pummerer-type-reaction).
Ikemizu
D
D
Department of Chemistry, College of Science and Engineering, Aoyama Gakuin University, Tokyo, Japan.
Matsuyama
A
A
Endo
T
T
Mitsunobu
O
O
D001583:Benzoxazoles; D007202:Indicators and Reagents; D013440:Sulfides; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D001583:Benzoxazoles; D007202:Indicators and Reagents; D013440:Sulfides; D013872:Thionucleosides