Arachidonic acid-sensitive A-currents and multiple Kv4 transcripts are expressed in chick ciliary ganglion neurons.
A-currents (IA) of chick ciliary ganglion (CG) neurons were blocked reversibly by arachidonic acid and a non-metabolizable analog of arachidonic acid, 5,8,11,14-eicosatetraynoic acid. Inhibition of IA by both lipids was observed in whole-cell recordings and in excised inside-out patches, suggesting that Kv4 (Shal) subunits contribute to functional IA channels in CG neurons. Consistent with this, Kv4.2 and Kv4.3 cDNAs were isolated by RT-PCR from chick CG neurons.
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Department of Biology and Biochemistry, University of Houston, TX 77204-5513, USA.
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D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology*; D002642:Chick Embryo; D004553:Electric Conductivity; D005726:Ganglia, Parasympathetic / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D015221:Potassium Channels / Q000235:genetics*; D024642:Potassium Channels, Voltage-Gated; D012333:RNA, Messenger / Q000378:metabolism*; D051672:Shal Potassium Channels
D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated; D012333:RNA, Messenger; D051672:Shal Potassium Channels; D016718:Arachidonic Acid