title: Chemistry of loteprednol etabonate and related steroids. II. Reactions at ring C and NMR structural studies of the resulting compounds.
abstract: Several derivatives of lotoprednol etabonate (1), a soft corticosteroid antiinflammatory drug, are formed during the synthesis and sterilization process. Some of these contaminants of 1 result from side reactions taking place on the steroid ring C including oxidation, dehydration, chlorination and chlorohydroxylation. The products have been identified, synthesized, and fully characterized by 1H and 13C NMR spectroscopy.
authors.affiliation: Pharmos Corporation, Alachua, Florida 32615, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rachwal
authors.forename: P
authors.initials: P
authors.lastname: Druzgala
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Vlasak
authors.forename: M E
authors.initials: ME
authors.lastname: Brewster
authors.forename: E
authors.initials: E
authors.lastname: Pop
mesh_terms: D000730:Androstadienes / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D000069559:Loteprednol Etabonate; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013256:Steroids / Q000737:chemistry*
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D013256:Steroids; D000069559:Loteprednol Etabonate