title: [Acne comedonica following radiation therapy].
abstract: METHODS
  A 50-year-old female patient underwent extirpation of a moderately differentiated, partially tubular ductal carcinoma of the left mamma and dissection of the left axilla followed by postoperative radiation therapy (total dose 58/48 gy). 2 weeks after the radiation therapy was stopped, treatment with goserelin subcutaneously was started. 6 weeks later numerous open and closed comedons appeared which were sharply confined to the radiation areas of left mamma and sternum.
  
  
  METHODS
  Because of the clinical diagnosis of acne comedonica following radiation therapy a local treatment with benzoyl-peroxide gel 5% and erythromycin cream 2% was performed, which led to improvement of the skin lesions within a few weeks and total restitution within 3 months. During one year no comedons have occurred although the local therapeutics are not applied constantly anymore.
  
  
  CONCLUSIONS
  Acne comedonica in the radiation area is a rarely known side effect of radiation therapy. Although the skin lesions cause no pain or itching they can affect the patient due to cosmetic changes. Local treatment with comedolytic acne therapeutics is effective.
authors.affiliation: Dermatologische Klinik und Poliklinik, Universität Regensburg.
authors.forename: S
authors.initials: S
authors.lastname: Karrer
authors.forename: C B
authors.initials: CB
authors.lastname: Schäfer
authors.forename: M
authors.initials: M
authors.lastname: Allgäuer
authors.forename: M
authors.initials: M
authors.lastname: Landthaler
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000209:etiology*; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000627:therapeutic use; D001940:Breast; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005782:Gels; D017273:Goserelin / Q000627:therapeutic use; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D011855:Radiodermatitis / Q000188:drug therapy / Q000209:etiology*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D013909:Thorax
chemical_list: D000900:Anti-Bacterial Agents; D018931:Antineoplastic Agents, Hormonal; D005782:Gels; D007641:Keratolytic Agents; D017273:Goserelin; D004917:Erythromycin; D001585:Benzoyl Peroxide
vernacular_title: Acne comedonica nach Strahlentherapie.