Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity in infants with bronchopulmonary dysplasia.
OBJECTIVE
The effects of anemia of prematurity during bronchopulmonary dysplasia (BPD) as well as on the metabolic and erythropoietic functions were determined before and after a transfusion. Fourteen anemic (Hb range: 65-88 gm/L), oxygen dependent (fraction of inspired oxygen < or = 35%), nonventilated, preterm infants with BPD were studied at a postnatal age of 6 +/- 2 weeks.


METHODS
Cardiac output, heart rate, mean velocity of circumferential fiber shortening, shortening fraction (SF), and stroke volume were assessed by pulsed and continuous wave Doppler echocardiography. Values for resting oxygen consumption, carbon dioxide production, and energy expenditure were obtained by indirect calorimetry. The affinity of oxygenated hemoglobin was determined by a blood oxygen dissociation analyzer.


RESULTS
An increased hemoglobin level resulted in a suppression of erythropoietin secretion (p < 0.001), whereas heart rate, cardiac output, stroke volume, and SF decreased (p < 0.05). Weight gain before and after transfusion were similar. Plasma lactate levels decreased from 1.6 +/- 0.3 to 1.2 +/- 0.3. Oxygen consumption, carbon dioxide production, and energy expenditure were not affected.


CONCLUSIONS
Anemia of prematurity and BPD increase heart rate, cardiac output, stroke volume, and SF. These hemodynamic compensatory responses are normalized by transfusion.
Bard
H
H
Neonatology and Cardiology Services, Hôpital Sainte-Justine, University of Montreal, Canada.
Fouron
J C
JC
Chessex
P
P
Widness
J A
JA
D000222:Adaptation, Physiological / Q000502:physiology; D000751:Anemia, Neonatal / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D001803:Blood Transfusion; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology* / Q000628:therapy; D015150:Echocardiography, Doppler; D004921:Erythropoietin / Q000378:metabolism*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D010102:Oxygen Inhalation Therapy
D004921:Erythropoietin