Distribution of apolipoprotein E4 isoform in Alzheimer's disease in Poland.
Alzheimer's disease (AD) is the most common human progressive dementia linked, in its sporadic form, to a common polymorphism within a gene for apolipoprotein E (APOE) mapped to chromosome 19. Individuals with APOE 4 isoforms are more prone to develop sporadic from of AD than those who carry APOE 2 or APOE 3 alleles. As distribution of APOE isoforms in Poland is unknown, we decided to study it in AD and control cases. In AD group, three patients (23.1%) were homozygous for APOE 4, four cases (30.8%) were heterozygous and six cases (46%) carried no APOE 4 allele. In control group (n-11), only one case (9.1%) was homozygous for APOE 4 allele, no case was heterozygous for APOE 4 while 10 cases (90.9%) carried no APOE 4 alleles. Our results are virtually identical to those reported from Western countries.
Bratosiewicz-Zapart
J
J
Laboratories of Tumor Biology, Department of Oncology, University Medical School, Lódź, Poland.
Kłoszewska
I
I
Sobów
T
T
Liberski
P P
PP
D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D004198:Disease Susceptibility; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic
D053327:Apolipoprotein E4; D001057:Apolipoproteins E