title: [Physiopathology of human superficial radiation-induced fibrosis].
abstract: The radiation-induced fibrosis is a late sequela of both therapeutic and accidental irradiations, and has been described in several tissues such as skin and underlying sub-cutaneous tissues, and lung. Based on the newest findings arising from cellular and molecular radiobiology, this review synthesis different aspects of the human superficial radiation-induced fibrosis: clinical and paraclinical observations, radiobiological aspects, gross histological changes, cellular and molecular regulations, and medical management. However, the underlying mechanisms of the superficial radiation-induced fibrosis still remain to be resolved.
authors.affiliation: Laboratoire de Radiobiologie et d'Etude du Génome, DSV-DRR, CEA-Saclay, Gif-sur-Yvette.
authors.forename: J L
authors.initials: JL
authors.lastname: Lefaix
authors.forename: S
authors.initials: S
authors.lastname: Delanian
authors.forename: B
authors.initials: B
authors.lastname: Dubray
mesh_terms: D005355:Fibrosis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D011832:Radiation Injuries / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D011836:Radiation Tolerance; D011853:Radiobiology; D011855:Radiodermatitis / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects*
vernacular_title: Physiopathologie de la fibrose radio-induite superficielle humaine.