Differential effects of chronic administration of the antidepressants amitriptyline and rolipram on adenylyl cyclase activity.
Significant increases were observed in guanylylimidodiphosphate- and fluoride-stimulated adenylyl cyclase activities in synaptic membrane preparations from rat cerebral cortex subsequent to the repeated administration of rolipram and amitriptyline. The potency of GppNHp-dependent inhibition of adenylyl cyclase was decreased by chronic treatment with rolipram but not by amitriptyline treatment. These findings suggest that chronically administered rolipram and amitriptyline share the augmentation of adenylyl cyclase activity by different actions on post-receptor signaling.
Saito
T
T
Department of Occupational Therapy, School of Health Sciences, Sapporo Medical University, Chuo-ku, Japan.
Ozawa
H
H
Kamata
H
H
Maeda
H
H
Takahata
N
N
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000639:Amitriptyline / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000201:enzymology; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D008297:Male; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020889:Rolipram; D015398:Signal Transduction / Q000187:drug effects; D013570:Synaptic Membranes / Q000201:enzymology
D000928:Antidepressive Agents; D011760:Pyrrolidinones; D000639:Amitriptyline; D006165:Guanylyl Imidodiphosphate; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases; D020889:Rolipram