[Antitumor activity and toxicity of combined doxorubicin and disodium salt of methylene-1,1-diphosphonic acid].
In experiments using mice and rats with transplantable Ehrlich ascites tumors, sarcoma-180 and adenocarcinoma of Walker, antitumor activity of doxorubicin in combination with disodium salt of 1,1-methylenediphosphonic acid proved higher than that of doxorubicin alone. Most advantage was gained with daily treatment. The toxic effect of said complex treatment seemed to differ slightly from that of doxorubicin as judged on the basis of survival, changes in body mass and peripheral blood count.
Stukov
A N
AN
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Mironiuk
T N
TN
Kon'kov
S A
SA
Krylova
I M
IM
Reztsova
V V
VV
Filov
V A
VA
Ivin
B A
BA
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use*; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D012492:Salts; D012513:Sarcoma, Experimental / Q000188:drug therapy; D012964:Sodium; D016019:Survival Analysis; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D004164:Diphosphonates; D012492:Salts; C027474:methylene diphosphonate; D004317:Doxorubicin; D012964:Sodium
O protivoopukholevoĭ aktivnosti i toksichnosti kompleksa doksorubitsina s dinatrievoĭ sol'iu metilen-1,1-difosfonovoĭ kisloty.