title: [Nosocomial infection over three years in a neonatal intensive care unit. Multivariate study].
abstract: BACKGROUND
  The Neonate Intensive Care Units (NICU) present high frequencies of hospital infections (HI) as well as patients with high intrinsic and extrinsic infection risks.
  
  
  METHODS
  A prospective study of 3 years in a NICU was carried out. Six-hundred and five neonates with stays longer than 48 hours were included. A descriptive study and a predictive equation, by non-conditional logistic regression, were performed, including the principal HI risk factors.
  
  
  RESULTS
  The HI incidence was 25.8/1,000 patients-day, and it was most frequent in children with weight lower than 2,500 g. The main etiologic agents were Streptococcus epidermis and Pseudomonas aeruginosa. The risk factors for HI in NICU were assisted respiration (odds ratio [OR] = 5.1; 95% CI, 2.3-11.5), low weight at birth (OR = 3.2; 95% CI, 1-1.08), transfusion (OR = 3.8; 95% CI, 1.4-10.1) and central venous catheter. Validation by ROC curve was satisfactory.
  
  
  CONCLUSIONS
  The incidence of HI in NICU is high, and depends on both disease features and instrumentation in NICU.
authors.affiliation: Departamento de Medicina Preventiva y Unidad de Vigilancia Intensiva Neonatal, Hospital La Paz, Madrid.
authors.forename: E
authors.initials: E
authors.lastname: Muñoz Platón
authors.forename: R
authors.initials: R
authors.lastname: Herruzo Cabrera
authors.forename: J
authors.initials: J
authors.lastname: García Caballero
authors.forename: M
authors.initials: M
authors.lastname: Fernández Arjona
authors.forename: J
authors.initials: J
authors.lastname: Quero
mesh_terms: D001724:Birth Weight; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D015999:Multivariate Analysis; D011446:Prospective Studies; D012307:Risk Factors
vernacular_title: Infección nosocomial durante tres años en una unidad de vigilancia intensiva neonatal. Estudio multivariante.