Motor slowing precedes cognitive impairment in the oldest old.
Eighty-five healthy elderly subjects were prospectively evaluated for 3 years to determine motor differences between those who remain cognitively intact and those who developed cognitive impairment during prospective follow-up. The 18 subjects who developed cognitive impairment had slower finger tapping and took longer to walk 30 feet before or at the time of cognitive impairment. Coordination was more impaired and steps, but not balance, deteriorated more rapidly, independent of other variables.
Camicioli
R
R
Department of Neurology, Oregon Health Sciences University, and the Veteran's Affairs Medical Center, Portland 97201-3098, USA.
Howieson
D
D
Oken
B
B
Sexton
G
G
Kaye
J
J
D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011597:Psychomotor Performance / Q000502:physiology*