title: [The mechanisms of the hepatotoxic action of the antitumor preparation vepesid].
abstract: It was shown in experiments on rats that intravenous infusion of the antitumor drug vepesid in a maximum tolerated dose causes stimulation of free-radical oxidation and changes in the fractional composition of lipids and phospholipids in the hepatic tissue. Changes in the activity of aminotransferases and alkaline phosphatase in the blood were recorded.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Vetoshkina
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Dubskaia
authors.forename: E A
authors.initials: EA
authors.lastname: Timina
authors.forename: V E
authors.initials: VE
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000633:toxicity*; D005047:Etoposide / Q000008:administration & dosage / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000032:analysis / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012545:Schiff Bases; D013997:Time Factors
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D008054:Lipid Peroxides; D010743:Phospholipids; D012545:Schiff Bases; D005047:Etoposide
vernacular_title: Mekhanizmy gepatotoksicheskogo deĭstviia protivoopukholevogo preparata vepezida.