[Anti-Candida activities of azole antifungals in the presence of lysozyme in vitro].
The combined effects of lysozyme and various antifungal agents were investigated by microbroth dilution method against Candida albicans in vitro. Synergistic anti-Candida activity was observed between egg white lysozyme and itraconazole, clotrimazole, miconazole and lanoconazole. Similar, although not as clear, combination anti-Candida activities were seen in the cases of ketoconazole, bifonazole, amphotericin B and nystatin. Anti-Candida activity of fluconazole was not affected by the addition of lysozyme, however. Physiological roles of this combination effect in anti-Candida therapy by azole antifungals were discussed.
Abe
S
S
Department of Microbiology and Immunology, Teikyo University School of Medicine. 2-11-1 Kaga Itabashi-ku Tokyo 173-8605, Japan.
Tansho
S
S
Perera
P D
PD
Hiratani
T
T
Nishiyama
Y
Y
Uchida
K
K
Yamaguchi
H
H
D000890:Anti-Infective Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D003022:Clotrimazole / Q000494:pharmacology*; D004357:Drug Synergism; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D017964:Itraconazole / Q000494:pharmacology*; D008825:Miconazole / Q000494:pharmacology*; D009113:Muramidase / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D007093:Imidazoles; D017964:Itraconazole; C072774:latoconazole; D008825:Miconazole; D009113:Muramidase; D003022:Clotrimazole