[Role of glutathione antiperoxide system in the mechanism of cytotoxic action of embichin].
Dynamics of changes in the peroxide level, contents of reduced and oxidized glutathione, activity of glutathione peroxidase and glutathione reductase in different organs of a rat under the influence of a single injection of embiquine in the dose of 1/2 DL50 was studied. Alkylating antitumor preparation was shown to cause the decrease of glutathione peroxidase and glutathione reductase activity. Activation glutathione antiperoxide system decreased cytotoxic effects of embiquine by prevention of lipoperoxid accumulation in the liver in the nearest periods of investigation after injection of the preparation, and in the kidney and spleen--during the whole period of investigation.
Boĭtsova
L V
LV
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000032:analysis / Q000378:metabolism*; D019803:Glutathione Disulfide / Q000032:analysis / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000032:analysis / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008466:Mechlorethamine / Q000633:toxicity*; D051381:Rats; D013050:Spectrometry, Fluorescence; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D018906:Antineoplastic Agents, Alkylating; D008466:Mechlorethamine; D005979:Glutathione Peroxidase; D005978:Glutathione; D019803:Glutathione Disulfide
Rol' glutationovoĭ antiperoksidnoĭ sistemy v mekhanizme tsitotoksicheskogo émbikhina.