[Study of 2-(2-hydroxy-3-isopropylaminopropoxy)-5-(propoxymethyl) acetophenone--a potential adrenoreceptor beta blocker affecting the function of myocardial mitochondria after administration of isoprenaline].
The present paper evaluated the effect of the potential beta-adrenoreceptor blocker 2-(3-isopropylamino-2-hydroxypropoxy)-5-(propoxymethyl) acetophenone (FoA33) on the oxidative and phosphorylating processes of the cardiac muscle influenced by small doses of isoprenaline (2 mg.kg-1). Under selected experimental conditions, the consumption of oxygen by the mitochondria of the cardiac muscle in states S3 and S4, rate of production of energy by mitochondria (OPR), coefficient of oxidative phosphorylyzation (ADP:O), respiratory control index (RCI) as well as the effect on the specific activity of the cytochromoxidase marker of mitochondria (COX) were examined. It follows from the obtained results that in contrast to large doses of isoprenaline (10-50 mg.kg-1) producing necrosis and affecting metabolic processes, small doses of isoprenaline (2 mg.kg-1) in many parameters activate the bioenergetic activity of the cardiac mitochondria, which is only minimally changed in combination with the beta-adrenoreceptor blocker (FoA33).
Cizmáriková
R
R
Farmaceutická fakulta Univerzity Komenského, Bratislava.
Gvozdjaková
A
A
Kucharská
J
J
D000098:Acetophenones / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
C112513:2-(2-hydroxy-3-isoprpylaminopropoxy)-5-(propoxymethy)acetophenone; D000098:Acetophenones; D000318:Adrenergic beta-Agonists; D011412:Propanolamines; D007545:Isoproterenol
Stúdium 2-(2-hydroxy-3-izopropylaminopropoxy)-5-(propoxymetyl) acetofenónu--potenciálneho blokátora beta-adrenoreceptorov na funkciu mitochondrií srdcového svalu ovplyvneného izoprenalínom.