title: Unexpected late graft failure 9 months after HLA-identical bone marrow transplant (BMT) for chronic myeloid leukemia (CML): treatment with a second BMT.
abstract: We describe a patient with CML in 1st chronic phase (CP) who experienced a graft failure 9 months after an HLA genotypically identical sibling BMT. Drug toxicity, viral infections, chronic graft-versus-host-disease (GVHD) or leukemic relapse were excluded. Chimerism study showed 85% of donor marrow cells. She underwent a second BMT, reengrafted but died of grade IV acute GVHD.
authors.forename: J J
authors.initials: JJ
authors.lastname: Gil-Fernández
authors.forename: R
authors.initials: R
authors.lastname: Arranz
authors.forename: R
authors.initials: R
authors.lastname: Cámara
authors.forename: A
authors.initials: A
authors.lastname: Alegre
authors.forename: A
authors.initials: A
authors.lastname: Figuera
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández-Rañada
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000209:etiology*; D006086:Graft vs Host Disease / Q000209:etiology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000628:therapy*; D012086:Reoperation; D013997:Time Factors
chemical_list: D006680:HLA Antigens