title: Behavioral effects of angiotensin II microinjected into CA1 hippocampal area.
abstract: The behavioral responses of rats to bilateral microinjections of angiotensin II (ATII) at doses of 0.1, 0.5 and 1.0 microg into the hippocampal CA1 area of male Sprague-Dawley rats were studied. ATII affected locomotor activity (the number of horizontal and vertical movements) in a dose-related U-shaped manner. In the elevated plus-maze experiments, ATII at a dose of 0.1 microg microinjected bilaterally into the CA1 hippocampal area increased the number of entries into the open arms, suggesting some anxiolytic effect.
authors.affiliation: Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia. irenata@iph.bio.acad.bg
authors.forename: I
authors.initials: I
authors.lastname: Belcheva
authors.forename: V
authors.initials: V
authors.lastname: Georgiev
authors.forename: M
authors.initials: M
authors.lastname: Chobanova
authors.forename: C
authors.initials: C
authors.lastname: Hadjiivanova
mesh_terms: D000704:Analysis of Variance; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001007:Anxiety / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D051381:Rats; D017207:Rats, Sprague-Dawley; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D000804:Angiotensin II