Laboratory guidelines for monitoring of antimicrobial drugs. National Academy of Clinical Biochemistry.
Few antimicrobial drugs meet the requirements for therapeutic drug monitoring. Those that are monitored include the aminoglycosides (gentamicin, tobramycin, and amikacin), chloramphenicol, and in some cases, vancomycin. For these drugs, there is evidence of a relationship between serum concentration, efficacy, and/or the incidence of adverse or toxic events. Monitoring begins with the appropriate timing of collection and continues through the analytical process to the integration of all data used to guide the clinician's next decision.
Hammett-Stabler
C A
CA
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610, USA. stabler.pathology@mail.health.ufl.edu
Johns
T
T
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D002701:Chloramphenicol / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use; D016903:Drug Monitoring / Q000592:standards*; D006801:Humans; D013048:Specimen Handling / Q000592:standards; D014640:Vancomycin / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D014640:Vancomycin