[Iodoantipyrine--an agent for treating and preventing tick-borne encephalitis].
The antiviral activity of iodantipyrine was studied in outbred [correction of inbred] albino mice (weight 10-12 g) infected with the Absettarov strain of the tick-borne encephalitis virus. Iodantipyrine was administered per os or parenterally and the animals were observed for 21 days. A reliable therapeutic effect was produced in 60% of mice infected with 10 DL50 of tick-borne encephalitis virus which were given the drug per os in a dose of 50 mg/kg. Preventive administration of the drug was effective in 47% of the animals.
Iavorovskaia
V E
VE
Siberian Medical University, Tomsk, Russia.
Saratikov
A S
AS
Fedorov
Iu V
IuV
Solianik
R G
RG
Anosova
G V
GV
Lepekhin
A V
AV
Portniagina
E V
EV
D000818:Animals; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000998:Antiviral Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control; D051379:Mice; D013994:Tilorone / Q000008:administration & dosage; D013997:Time Factors
D000998:Antiviral Agents; D013994:Tilorone; D000983:Antipyrine; C008135:iodoantipyrine
Iodantipirin--sredstvo dlia lecheniia i profilaktiki kleshchevogo éntsefalita.