Molecular cloning of a novel chemokine receptor-like gene from early stage chick embryos.
Proliferation, differentiation and regulated trafficking of cells are the hallmarks of development and embryogenesis. This led us to speculate a role for chemokines and their receptors in this process. Here, we report the molecular cloning of AvCRL1, a novel member of the G-protein coupled receptor family from early stage 3 days old chick embryos. While the function and ligand for this receptor remain unknown, its sequence and gene structure indicates that it is most related to the family of chemokine receptors, with highest homology to the virally induced human BLR-1 and the CXCR3 or gammaIP-10/Mig-1 receptors.
Gupta
S K
SK
Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA. Shalley_K_Gupta@sbphrd.com
Pillarisetti
K
K
Gray
S L
SL
Stadel
J M
JM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D018925:Chemokines / Q000502:physiology; D002642:Chick Embryo; D003001:Cloning, Molecular; D005314:Embryonic and Fetal Development / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012313:RNA / Q000235:genetics / Q000378:metabolism; D019707:Receptors, Chemokine / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic
D018925:Chemokines; D019707:Receptors, Chemokine; D012313:RNA