title: Changes in regional cerebral blood flow beyond the temporal lobe in unilateral temporal lobe epilepsy.
abstract: OBJECTIVE
  Single photon emission computed tomography (SPECT) is widely used to evaluate functional abnormalities during the epileptic event. Changes in regional cerebral blood flow (rCBF) are well defined in patients with temporal lobe epilepsy (TLE) undergoing surgical resection. Nonetheless, the interpretation of ictal abnormalities in CBF beyond the temporal lobes has not been carefully addressed.
  
  
  METHODS
  We assessed 4 patients with pathologically proven unilateral TLE who had significant ipsilateral frontal hypoperfusion in ictal studies with no other abnormalities but chronic epilepsy accounting for such findings. Patients were assessed as candidates for surgery by interictal EEG, neuropsychological studies, brain magnetic resonance imaging, scalp electrode video-EEG monitoring, and ictal SPECT.
  
  
  RESULTS
  Characteristic hyperperfusion was evident over the temporal lobe ipsilateral to the EEG focus, with significant hypoperfusion over the frontal region in 3 patients. In patient 4, frontal hypoperfusion was not statistically significant.
  
  
  CONCLUSIONS
  SPECT demonstrated relative rCBF changes beyond the epileptogenic zone in unilateral TLE. Our findings provide further insight into the pathophysiological changes underlying this condition.
authors.affiliation: Department of Neurology, Raul Carrea Institute for Neurological Research, Fleni, Buenos Aires, Argentina.
authors.forename: A L
authors.initials: AL
authors.lastname: Rabinowicz
authors.forename: E
authors.initials: E
authors.lastname: Salas
authors.forename: F
authors.initials: F
authors.lastname: Beserra
authors.forename: R C
authors.initials: RC
authors.lastname: Leiguarda
authors.forename: S E
authors.initials: SE
authors.lastname: Vazquez
mesh_terms: D000328:Adult; D003545:Cysteine / Q000031:analogs & derivatives; D017029:Epilepsy, Complex Partial / Q000000981:diagnostic imaging / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D013702:Temporal Lobe / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine