title: Does ADHD affect the course of substance abuse? Findings from a sample of adults with and without ADHD.
abstract: The authors examined the effects of attention-deficit hyperactivity disorder (ADHD) and psychiatric comorbidity on recovery from psychoactive substance use disorder (PSUD) with 130 referred adults with ADHD and 71 non-ADHD adults, all of whom had a lifetime history of PSUD. Although PSUD remitted in 80% of both groups, the rate of remission and duration of PSUD was quite different in the ADHD vs. non-ADHD subjects. The duration of PSUD was 37.2 months longer in the ADHD than in non-ADHD subjects. The median time to PSUD remission was more than twice as long in ADHD than in control subjects (144 vs. 60 months, respectively). ADHD is associated with a longer, duration of PSUD and a significantly slower remission rate. If confirmed, such findings extend previous work showing that ADHD is a risk factor for early initiation and specific pathways of PSUD, providing further evidence of the relevance of this association.
authors.affiliation: Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: T E
authors.initials: TE
authors.lastname: Wilens
authors.forename: J
authors.initials: J
authors.lastname: Biederman
authors.forename: E
authors.initials: E
authors.lastname: Mick
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome