Structure of DNA containing aristeromycin analog.
The melting temperatures and thermodynamic properties of several oligodeoxynucleotide duplexes containing one modified deoxyadenosine residue (carbocyclic deoxyadenosine, dAr) were investigated. It was found that the introduction of carbocyclic deoxyadenosine slightly destabilized oligonucleotide duplexes mainly due to an entropic contribution.
Fujiwara
T
T
Institute of Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
Sugiyama
H
H
Saito
I
I
D000225:Adenine / Q000031:analogs & derivatives*; D000241:Adenosine / Q000031:analogs & derivatives*; D001483:Base Sequence; D002151:Calorimetry; D003517:Cyclopentanes; D004247:DNA / Q000737:chemistry*; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D013816:Thermodynamics
D003517:Cyclopentanes; D009838:Oligodeoxyribonucleotides; C113082:carbocyclic deoxyadenosine; C030034:aristeromycin; D004247:DNA; D000225:Adenine; D000241:Adenosine