Local injection of alkylating and nonalkylating dopamine receptor antagonists into rat basal forebrain: autoradiographic assessment of D2-like and D3 sites.
N-chloroethyl derivatives of 7-hydroxy-1,2,3,4-tetrahydronaphthalene (7-OH-DPAT), 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), or fluphenazine were microinjected into rat nucleus accumbens (Acc), and receptor binding quantified autoradiographically after 24 h. EEDQ reduced [3H]nemonapride (D2-like receptors) binding in Acc (by 84%) and islands of Calleja (IC; 44%), without affecting [3H](+)-7-OH-DPAT (D3); N-chloroethyl-7-OH-DPATs blocked both radioligands in Acc and IC (30%-70%); fluphenazine had no effect.
Yeghiayan
S K
SK
Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA. syeghiayan@natick-ccmail.army.mil
Gongwer
M A
MA
Baldessarini
R J
RJ
Kula
N S
NS
Zong
R
R
Neumeyer
J L
JL
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001427:Bacterial Toxins / Q000494:pharmacology; D002135:Calcium-Binding Proteins; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005476:Fluphenazine / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009714:Nucleus Accumbens / Q000737:chemistry / Q000187:drug effects; D016548:Prosencephalon / Q000737:chemistry* / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D010738:Type C Phospholipases / Q000494:pharmacology
D000477:Alkylating Agents; D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; C493595:Drd3 protein, rat; D011804:Quinolines; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; C000470:EEDQ; D010738:Type C Phospholipases; C040649:alpha toxin, Clostridium perfringens; C031349:7-hydroxy-2-N,N-dipropylaminotetralin; D005476:Fluphenazine