[The detection of the antibodies of human cytomegalovirus in the sera of patients with coronary heart disease].
To explore the relationship between human cytomegalovirus infection and atherosclerosis, we assayed the antibodies of human cytomegalovirus in the sera of 106 patients with coronary heart disease and 80 healthy people by indirect ELISA technique. The results showed that the positive rate of antibodies of HCMV IgG, HCMV IgM and HCMV IgA (95.3%, 12.3%, 13.2% respectively) is significantly higher than that in healthy people (85.0%, 2.5%, 3.8% respectively). Our findings indicated that HCMV infection is related to coronary heart disease. We consider that HCMV may be an etiological factor for human atherosclerosis. The periodical activation of latent HCMV may play a role in atherogenesis.
Li
B
B
Department of Cardiology, People's Hospital, Beijing Medical University, Beijing.
Xu
C
C
Wang
Q
Q
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D003327:Coronary Disease / Q000821:virology*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000821:virology
D000914:Antibodies, Viral