title: A new approach to the development of anti-ischemic drugs: protective drugs against cell injury induced by lysophosphatidylcholine.
abstract: Recent studies have revealed that lysophosphatidylcholine (LPC) produces mechanical and metabolic derangements in perfused working rat hearts and Ca2+-overload in isolated cardiac myocytes. Thus, LPC possesses an ischemia-like effect on the heart. Therefore, a drug that possesses an anti-LPC action would protect or improve ischemia/reperfusion damage. We examined the effects of various anti-ischemic drugs on the Ca2+ overload induced by LPC. Our data suggest that a drug with high lipophilicity possesses a protective effect on cell injury induced by LPC, probably because of preservation of membrane integrity.
authors.affiliation: Department of Pharmacology, Asahikawa Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hashizume
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Ma
authors.forename: A
authors.initials: A
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Yazawa
authors.forename: M
authors.initials: M
authors.lastname: Akahira
authors.forename: C Y
authors.initials: CY
authors.lastname: Xiao
authors.forename: Y
authors.initials: Y
authors.lastname: Abiko
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D008244:Lysophosphatidylcholines / Q000037:antagonists & inhibitors* / Q000633:toxicity; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism; D051381:Rats
chemical_list: D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D008244:Lysophosphatidylcholines; D002118:Calcium