Effect of endotoxin on the concentration of triacylglycerols in the liver of the rat.
The aim of the present study was to examine an effect of endotoxin E.coli O127:B8 on the concentrations of triacylglycerol (TG) in the rat's liver. The rats were divided into the following groups: control, treated with one dose of endotoxin, treated with three doses of endotoxin. The rats had free access to food (pallet diet for rodents) and water. Endotoxin E.coli O127:B8 was injected interperitoneally in dose of 3 mg/kg b.w.--once or three times at intervals of 72 hrs. One dose of endotoxin decreased blood serum TG concentration, although the concentration of liver TG was increased after 24 hrs. Triple doses of endotoxin given at 72 hrs intervals increased the blood serum TG concentration after 24 hrs, but had no effect on the liver concentration.
Hryniewicz
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A
Department of Clinical Physiology, Medical Academy of Białystok.
Kozłowska
H
H
Puch
U
U
D000818:Animals; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D004926:Escherichia coli / Q000145:classification; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007274:Injections, Intraperitoneal; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000737:chemistry*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014280:Triglycerides / Q000032:analysis* / Q000097:blood
D004731:Endotoxins; D005230:Fatty Acids, Nonesterified; D008070:Lipopolysaccharides; D014280:Triglycerides