Increased incidence of myositis in patients treated with high-dose simvastatin.
Galper
J B
JB
D000818:Animals; D002478:Cells, Cultured; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D003402:Creatine Kinase / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000187:drug effects / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D015994:Incidence; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009220:Myositis / Q000139:chemically induced* / Q000453:epidemiology / Q000378:metabolism; D051381:Rats; D019821:Simvastatin / Q000008:administration & dosage / Q000009:adverse effects*
D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D003402:Creatine Kinase; D019204:GTP-Binding Proteins