[The effect of analogs of the C-termination fragment of arginyl vasopressin on the dynamics of the acquisition of an active avoidance conditioned reaction in rats].
The effect of original analogues of the 6-9 C-terminal AVP fragment, D-MRP and D-MPRG, on the active avoidance behaviour of rats was studied using intranasal administration in a wide range of doses. The dose in 0.1 mcg/kg was the most efficient for D-MPR and 0.01 mcg/kg for D-MPRG, which for the tripeptide was ten times, and for the tetrapeptide hundred times lower than the corresponding dose of AVP used in the similar experiments. The tri- and tetrapeptide were shown to facilitate the active avoidance behaviour affecting both the formation of the reaction and consolidation of memory trace. The peptides mostly affect the perception processes, i.e., the detection of a specific stimulus from the environment, the estimation and memorizing of its biological significance.
Voskresenskaia
O G
OG
Lomonosov State University, Moscow.
Titov
S A
SA
Kamenskiĭ
A A
AA
Golubovich
V P
VP
Ashmarin
I P
IP
D000161:Acoustic Stimulation; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016009:Chi-Square Distribution; D003214:Conditioning, Classical / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats
D010446:Peptide Fragments; C112794:acetylmethionyl-prolyl-arginine; C112795:acetylmethionyl-prolyl-arginyl-glycinamide; D001127:Arginine Vasopressin
Vliianie analogov C-kontsevogo fragmenta arginilvazopressina na dinamiku vyrabotki uslovnoĭ reaktsii aktivnogo izbeganiia u krys.