title: Cymbimicin A and B, two novel cyclophilin-binding structures isolated from actinomycetes.
abstract: Two novel metabolites, cymbimicins A and B, were isolated from the culture broth of a strain of Micromonospora sp. by screening for cyclophilin binding metabolites from actinomycete strains. Cymbimicin A binds to cyclophilin A with a high affinity six fold lower than to that of cyclosporin A. The binding affinity of cymbimicin B is about 100 times lower. The taxonomy of the producing strain, fermentation, isolation, physical and biological properties and structure elucidation are described.
authors.affiliation: Novartis Pharma Inc., Preclinical Research, Basel, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Fehr
authors.forename: V F
authors.initials: VF
authors.lastname: Quesniaux
authors.forename: J J
authors.initials: JJ
authors.lastname: Sanglier
authors.forename: L
authors.initials: L
authors.lastname: Oberer
authors.forename: L
authors.initials: L
authors.lastname: Gschwind
authors.forename: M
authors.initials: M
authors.lastname: Ponelle
authors.forename: W
authors.initials: W
authors.lastname: Schilling
authors.forename: S
authors.initials: S
authors.lastname: Wehrli
authors.forename: A
authors.initials: A
authors.lastname: Enz
authors.forename: G
authors.initials: G
authors.lastname: Zenke
authors.forename: W
authors.initials: W
authors.lastname: Schuler
mesh_terms: D001667:Binding, Competitive / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005285:Fermentation; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008847:Micromonospora / Q000737:chemistry* / Q000378:metabolism; D019696:Peptidylprolyl Isomerase / Q000378:metabolism
chemical_list: D007166:Immunosuppressive Agents; D007783:Lactones; C111286:cymbimicin A; C111287:cymbimicin B; D019696:Peptidylprolyl Isomerase