title: Antibacterial activity of lonchocarpol A.
abstract: Lonchocarpol A, a flavanone, demonstrates in vitro inhibitory activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. This activity is antagonized by mouse plasma, which may account for its lack of in vivo activity. This compound demonstrates no differentiation with respect to the inhibition of RNA, DNA, cell wall, and protein synthesis.
authors.affiliation: Merck Research Laboratories, Rahway, New Jersey 07065, USA. Michael_Salvatore@Merck.com
authors.forename: M J
authors.initials: MJ
authors.lastname: Salvatore
authors.forename: A B
authors.initials: AB
authors.lastname: King
authors.forename: A C
authors.initials: AC
authors.lastname: Graham
authors.forename: H R
authors.initials: HR
authors.lastname: Onishi
authors.forename: K F
authors.initials: KF
authors.lastname: Bartizal
authors.forename: G K
authors.initials: GK
authors.lastname: Abruzzo
authors.forename: C J
authors.initials: CJ
authors.lastname: Gill
authors.forename: H G
authors.initials: HG
authors.lastname: Ramjit
authors.forename: S M
authors.initials: SM
authors.lastname: Pitzenberger
authors.forename: K M
authors.initials: KM
authors.lastname: Witherup
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001410:Bacillus megaterium / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D016984:Enterococcus faecium / Q000187:drug effects; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D008826:Microbial Sensitivity Tests; D009036:Moths / Q000737:chemistry; D009161:Mycobacterium / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D007529:Isoflavones; C068505:senegalensin