Acceleration of virus-induced apoptosis by tumor necrosis factor.
The multiplication of vesicular stomatitis virus in HeLa cells was inhibited by treating the cells with tumor necrosis factor (TNF). Comparison of the kinetics of virus multiplication and that of virus-induced apoptosis in the TNF-treated cells revealed that the antiviral effect of TNF is accompanied by a rapid induction of apoptosis in the cells upon infection, suggesting that TNF can inhibit virus multiplication by accelerating an apoptotic response in the infected cells.
Koyama
A H
AH
Department of Virology, School of Medicine, The University of Tokushima, Japan. koyama@basic.med.tokushima-u.ac.jp
Arakawa
T
T
Adachi
A
A
D000998:Antiviral Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002467:Cell Nucleus / Q000648:ultrastructure; D053938:DNA Fragmentation; D006367:HeLa Cells; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D014409:Tumor Necrosis Factor-alpha