The Eph family receptors and ligands.
The Eph family is the largest of all known tyrosine kinase receptor-ligand systems. They are expressed in distinct, but overlapping, spatial and temporal patterns during embryonic development and postnatal life, and function in a variety of morphogenic events. The best known function is their role in the guidance of migration of axons and cells in the nervous system through repulsive interactions. They may also play a role in angiogenesis, tissue patterning, and tumor formation.
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Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA.
D000595:Amino Acid Sequence; D000818:Animals; D001369:Axons / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics; D018919:Neovascularization, Physiologic / Q000502:physiology; D009420:Nervous System / Q000254:growth & development / Q000648:ultrastructure; D009434:Neural Pathways / Q000254:growth & development / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D008024:Ligands; D020794:Receptor Protein-Tyrosine Kinases