Effect of granisetron on morphine-induced analgesia in mice by formalin test.
1. In this investigation, the influence of a selective 5HT3 antagonist, granisetron, on morphine-induced antinociception in the formalin test has been studied. There is evidence that the 5HT3 receptor system takes part in analgesic response. 2. Male albino mice weighing 22-27 g were used in the experiments. All drugs were administered 30 min before formalin injection. Comparison between groups was made by analysis of variance and then Newman-Keuls test. 3. Different doses of morphine (1.5-9.0 mg/kg) subcutaneously induced antinociception in both phases of the formalin test. 4. Coadministration of granisetron (0.1-10.0 mg/kg) intraperitoneally had no effect on morphine analgesia, but granisetron injection alone induced dose-dependent analgesia in both phases of the formalin test. 5. Results of this study suggest a role for a new selective 5HT3 antagonist in analgesia.
Nikfar
S
S
Department of Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Iran.
Abdollahi
M
M
Kebriaeezadeh
A
A
Chitsaz
M
M
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D017829:Granisetron / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D010147:Pain Measurement; D012702:Serotonin Antagonists / Q000494:pharmacology*
D000701:Analgesics, Opioid; D017829:Granisetron; D009020:Morphine; D012702:Serotonin Antagonists