title: Solid phase synthesis of benzamidine-derived sulfonamide libraries.
abstract: Using solid phase synthesis, a library has been constructed of benzamidine-derived sulfonamides which have strong inhibitory activity against blood coagulant thrombin. The library compounds were obtained in good yield and high purity.
authors.affiliation: Biotech Research Institute, LG Chemical Ltd., Science Town, Taejon, Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Kim
authors.forename: C Y
authors.initials: CY
authors.lastname: Hong
authors.forename: J S
authors.initials: JS
authors.lastname: Koh
authors.forename: E J
authors.initials: EJ
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: Lee
mesh_terms: D001550:Benzamidines / Q000138:chemical synthesis*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D015394:Molecular Structure; D012116:Resins, Plant; D013449:Sulfonamides / Q000138:chemical synthesis*; D013917:Thrombin / Q000037:antagonists & inhibitors
chemical_list: D001550:Benzamidines; D004791:Enzyme Inhibitors; D012116:Resins, Plant; D013449:Sulfonamides; D013917:Thrombin