The alpha beta versus gamma delta T-cell lineage choice.
During thymic development, immature T cells rearrange and express the genes encoding the T-cell antigen receptor and mature as either alpha beta or gamma delta lineage T cells. In the past year, advances have been made in understanding the role of individual components of the T-cell antigen receptor complex in the development of alpha beta and gamma delta lineage T cells. In addition, the transmembrane receptor Notch has recently been implicated as a new player in alpha beta versus gamma delta lineage determination.
Robey
E
E
Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA. erobey@uclink4.berkeley.edu
Fowlkes
B J
BJ
D000818:Animals; D019070:Cell Lineage; D006801:Humans; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000502:physiology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000502:physiology*; D013601:T-Lymphocytes / Q000737:chemistry / Q000166:cytology*
D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta