title: Estimation of the effect of increasing UVB exposure on the human immune system and related resistance to infectious diseases and tumours.
abstract: Exposure to UV light has, besides some beneficial effects (vitamin D production), many harmful effects on human health. UVB irradiation has been shown to suppress both systemic and local immune responses to a variety of antigens, including some microorganisms. However, it is still not known whether such immunomodulating effects may lead to an increase in the number and severity of certain tumours and/or infections in humans. We report herein the data provided by a project that was funded by the European Union (Programme Environment), and that was aimed at the estimation of the risk associated with increased UVB exposure due to ozone depletion regarding the deleterious effects on the immune system and related resistance to tumours and infections in humans. The data, obtained by the different research groups involved, were assembled and used to calculate for the first time a risk assessment for increased environmental exposure to UVB in human subjects.
authors.affiliation: National Institute of Public Health, Department of Pathology and Immunobiology, Bilthoven, Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Garssen
authors.forename: M
authors.initials: M
authors.lastname: Norval
authors.forename: A
authors.initials: A
authors.lastname: el-Ghorr
authors.forename: N K
authors.initials: NK
authors.lastname: Gibbs
authors.forename: C D
authors.initials: CD
authors.lastname: Jones
authors.forename: D
authors.initials: D
authors.lastname: Cerimele
authors.forename: C
authors.initials: C
authors.lastname: De Simone
authors.forename: S
authors.initials: S
authors.lastname: Caffieri
authors.forename: F
authors.initials: F
authors.lastname: Dall'Acqua
authors.forename: F R
authors.initials: FR
authors.lastname: De Gruijl
authors.forename: Y
authors.initials: Y
authors.lastname: Sontag
authors.forename: H
authors.initials: H
authors.lastname: Van Loveren
mesh_terms: D000818:Animals; D003141:Communicable Diseases / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology* / Q000528:radiation effects*; D007113:Immunity, Innate / Q000528:radiation effects; D007165:Immunosuppression Therapy; D009369:Neoplasms / Q000276:immunology*; D012307:Risk Factors; D012867:Skin / Q000528:radiation effects; D012878:Skin Neoplasms / Q000209:etiology; D014466:Ultraviolet Rays