Excimer laser for various degrees of myopia. A new model estimating the immediate response, the regression, the final response and the time relationship.
OBJECTIVE
To demonstrate a unified model for various degrees of myopia, characterizing the response-time relationship and its influence of topical corticosteroids.


METHODS
84 eyes were treated with excimer laser for myopia (median -7.1 D). 50 eyes received topical NSAID for 4 days (group 1), and 34 eyes (group 2) were further treated postoperatively with bandage lens and topical corticosteroids for three months. The response-time relationship was expressed as P(t)=a+b*exp(k*t), where P(t) is the response expressed as the percent change in dioptric power to the postoperative time t, a is the final percent response, b is the total percent regression and k the time constant. a+b express the percent immediate response and T1/2=0.69/k denote the time within which half of the total regression has occurred.


RESULTS
The immediate and final responses were significantly larger in group 2 (128.9% and 70.5%) compared with group 1 (110.5% and 59.8%). T1/2 was significantly longer in group 2 (2.1 month) compared with group 1 (0.8 month)


CONCLUSIONS
Use of bandage lens together with steroids significantly influences the response-time relationship after excimer laser treatment for myopia.
Edmund
C
C
Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Denmark.
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D003315:Cornea / Q000503:physiopathology; D006801:Humans; D053685:Laser Therapy; D008875:Middle Aged; D009216:Myopia / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D009779:Occlusive Dressings; D011184:Postoperative Period; D012029:Refraction, Ocular / Q000502:physiology; D013997:Time Factors; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal