Advances in periodontal diagnosis. 6. Proteolytic and hydrolytic enzymes of inflammatory cell origin.
Potential proteolytic and hydrolytic enzymes of inflammatory cell origin might serve as biomarkers of periodontal disease activity. The role of these enzymes in periodontal pathology, particularly in respect of collagen and proteoglycan degradation, is discussed. The cellular location of these enzymes and their normal control mechanisms by endogenous inhibitors is described.
Eley
B M
BM
Periodontal Department, King's College School of Medicine and Dentistry, London.
Cox
S W
SW
D015415:Biomarkers / Q000032:analysis; D003094:Collagen / Q000378:metabolism; D017364:Collagenases / Q000032:analysis; D003238:Connective Tissue / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000032:analysis* / Q000037:antagonists & inhibitors; D007249:Inflammation; D008264:Macrophages / Q000201:enzymology; D008407:Mast Cells / Q000201:enzymology; D009504:Neutrophils / Q000201:enzymology; D010447:Peptide Hydrolases / Q000032:analysis*; D010510:Periodontal Diseases / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D010519:Periodontium / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology; D011509:Proteoglycans / Q000378:metabolism
D015415:Biomarkers; D004791:Enzyme Inhibitors; D006025:Glycosaminoglycans; D011480:Protease Inhibitors; D011509:Proteoglycans; D003094:Collagen; D006867:Hydrolases; D010447:Peptide Hydrolases; D017364:Collagenases