Caspases: key mediators of apoptosis.
Recent studies have established that members of the caspase protease family are essential components of a conserved cell death program. Insights into their biological roles, structure and mechanism are enabling investigators to begin to explore the therapeutic potential of caspase inhibition.
Thornberry
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Merck Research Laboratories, Rahway, NJ 07065, USA. nancy_thornberry@merck.com
D000818:Animals; D017209:Apoptosis; D002384:Catalysis; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D011487:Protein Conformation; D013379:Substrate Specificity
D015853:Cysteine Proteinase Inhibitors; D003546:Cysteine Endopeptidases