title: Meta-analysis of randomized clinical trials of finasteride.
abstract: A meta-analysis was recently published based on six randomized clinical trials of at least one year duration involving finasteride 5 mg and placebo in the treatment of men with clinical benign prostatic hyperplasia (BPH). In a pooled analysis, mean improvement in symptoms and urinary flow rate with finasteride were found to increase with increasing prostate size. This article reviews the previous publication of this meta-analysis, which indicated prostate volume is a key predictor of outcomes with finasteride treatment and suggested that finasteride is most effective in men with large prostates.
authors.affiliation: University of Texas Southwestern Medical Center, Section of Urology, Veterans Administration North Texas Health Care System, Dallas 75232-9110, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Roehrborn
mesh_terms: D018120:Finasteride / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D016032:Randomized Controlled Trials as Topic
chemical_list: D018120:Finasteride