Activity of lysosomal and nonlysosomal proteases of fibrosarcoma induced by methylcholanthrene.
Activity of lysosomal (cathepsins A,B,C,D and E) and nonlysosomal proteases (cathepsin G, elastase, collagenase, prolidase, prolinase) was evaluated in fibrosarcoma induced in rats by methylcholanthrene. No differences were found in the activity of the examined proteases in tumours of different size in the external, intermediate and central spheres of these tumours. Activity of cathepsins A,B,C,D,E and G, prolidase and prolinase was higher in the fibrosarcoma and activity of collagenase and elastase was lower than in the rat skin.
Gołaszewski
Z
Z
Department of Instrumental Analysis, Medical Academy of Białystok.
Sobolewski
K
K
Gołaszewska
J
J
Pałka
J
J
Ostrowska
H
H
D000818:Animals; D002268:Carboxypeptidases / Q000378:metabolism; D002273:Carcinogens; D043402:Cathepsin A; D002401:Cathepsin B / Q000378:metabolism; D020789:Cathepsin C; D002402:Cathepsin D / Q000378:metabolism; D020059:Cathepsin E; D056649:Cathepsin G; D002403:Cathepsins / Q000378:metabolism; D017364:Collagenases / Q000378:metabolism; D004150:Dipeptidases / Q000378:metabolism; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism*; D005354:Fibrosarcoma / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000378:metabolism; D012867:Skin / Q000201:enzymology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology
D002273:Carcinogens; D008748:Methylcholanthrene; D002268:Carboxypeptidases; D002403:Cathepsins; D010450:Endopeptidases; D004150:Dipeptidases; C022454:prolyl dipeptidase; C022449:proline dipeptidase; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D020789:Cathepsin C; D043402:Cathepsin A; D012697:Serine Endopeptidases; D056649:Cathepsin G; C534097:Ctsg protein, rat; D002401:Cathepsin B; D020059:Cathepsin E; D002402:Cathepsin D; D017364:Collagenases