title: [Experimental study of the biopreparation Lymphotilin as an antiproliferative and antitumor agent].
abstract: We found in experiments involving the use of a biopreparation lymphotilin that its administration was followed by a decrease in proliferative activity of cultured tumor cells and a longer survival of mice bearing transplantable leukemia. An intensified intercalation of ethidium bromide in nucleic acids of tumor cells in lymphotilin culture points to the drug activity on nuclear level. Tumor cell inhibition by lymphotilin holds much promise for the practice of hematology.
authors.affiliation: State Research Institute of Super Pure Biopreparations, St. Petersburg.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Tiagotin
authors.forename: A E
authors.initials: AE
authors.lastname: Polotskiĭ
authors.forename: T Ia
authors.initials: TIa
authors.lastname: Vakhitov
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Tutova
authors.forename: L P
authors.initials: LP
authors.lastname: Rybakova
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004996:Ethidium / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000188:drug therapy*; D007962:Leukocytes / Q000187:drug effects*; D051379:Mice; D009696:Nucleic Acids / Q000187:drug effects; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D009696:Nucleic Acids; D004996:Ethidium
vernacular_title: Eksperimental'noe izucheniie biopreparata Limfotilin kak antiproliferativnogo i protivoopukholevogo sredstva.