The impact of L1 retrotransposons on the human genome.
The 'master' human mobile element, the L1 retrotransposon, has come of age as a biological entity. Knowledge of how it retrotransposes in vivo, how its proteins act to retrotranspose other poly A elements and the extent of its role in shaping the human genome should emerge rapidly over the next few years. We review the impact of retrotransposons and how new insight is likely to lead to important practical applications for these intriguing mobile elements.
Kazazian
H H
HH
Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia 19104, USA. kazazian@mail.med.upenn.edu
Moran
J V
JV
D015894:Genome, Human; D006801:Humans; D018626:Retroelements
D018626:Retroelements