Effect of prostaglandin E1 on pulmonary hypertension after protamine injection during cardiac surgery.
BACKGROUND
The effects of prostaglandin E1 on pulmonary hypertension were assessed after protamine injection at the end of cardiopulmonary bypass during cardiac surgery.


METHODS
Ten patients scheduled for cardiac surgery presented with pulmonary hypertension (mean pulmonary artery pressure greater than 30 mmHg) after protamine injection and were treated by infusion of 0.02 microg x kg(-1) x min(-1) prostaglandin E1. Hemodynamic measurements were made on occasions after cardiopulmonary bypass. Prostaglandin E1 decreased pulmonary artery pressure, pulmonary vascular resistance, right ventricular stroke work index and pulmonary vascular resistance/systemic vascular resistance ratio, but did not change blood pressure, systemic vascular resistance, left ventricular stroke work index or cardiac output.


CONCLUSIONS
Prostaglandin E1 normalized pulmonary hypertension after protamine injection, but did not change arterial blood pressure and cardiac output.
Abe
K
K
Department of Anaesthesiology, Osaka University Medical School, Suita, Japan. abe@anes.med.osaka-u.ac.jp
Sakakibara
T
T
Miyamoto
Y
Y
Ohnishi
K
K
D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006494:Heparin Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011479:Protamines / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
D006494:Heparin Antagonists; D011479:Protamines; D000527:Alprostadil