title: Quantitative assessment of bone marrow hematopoiesis using parametric magnetic resonance imaging.
abstract: Spatial maps of the percentage cellularity in pelvic bone marrow were calculated at a resolution of 15.6 mm3 from six volunteers and 10 patients treated for documented hematologic disease using a three-point Dixon MRI pulse sequence. The percentage cellularity calculation was aided by analyzing a two-dimensional feature space consisting of the apparent water fraction (Wa), and the T2 relaxation time of water (T2w). An extracellular water fraction was assigned to each voxel on the basis of a two-component T2w algorithm. In six cases, the method was compared to results obtained from core biopsies or aspirates of the posterior iliac crest. The results indicate that segmentation schemes that combine high-quality phase-contrast imaging with nuclear relaxation time measurements can potentially identify the true fractional marrow volume occupied by hematopoietic elements in a variety of clinical situations.
authors.affiliation: Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
authors.forename: D
authors.initials: D
authors.lastname: Ballon
authors.forename: A A
authors.initials: AA
authors.lastname: Jakubowski
authors.forename: P K
authors.initials: PK
authors.lastname: Tulipano
authors.forename: M C
authors.initials: MC
authors.lastname: Graham
authors.forename: E
authors.initials: E
authors.lastname: Schneider
authors.forename: B
authors.initials: B
authors.lastname: Aghazadeh
authors.forename: Q S
authors.initials: QS
authors.lastname: Chen
authors.forename: J A
authors.initials: JA
authors.lastname: Koutcher
mesh_terms: D000328:Adult; D000465:Algorithms; D001706:Biopsy; D001853:Bone Marrow / Q000033:anatomy & histology* / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D006402:Hematologic Diseases / Q000473:pathology; D006410:Hematopoiesis; D006801:Humans; D007085:Ilium / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged