title: Localized limb cutaneous metastases.
abstract: Cutaneous metastatic disease may be evident in a variety of forms and locations. Anatomically, it may on occasion be confined as localized limb metastases. We report on two patients with localized limb metastases, one from melanoma and the other from Merkel cell carcinoma. Patients with localized limb metastasis have a poor prognosis; however, treatment options not available for generalized cutaneous metastatic disease, such as amputation or isolated limb perfusion with chemotherapeutic agents, can be at times be beneficially employed.
authors.affiliation: Division of Dermatology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033, USA. Khelm@med.hmc.psghc.edu
authors.forename: K F
authors.initials: KF
authors.lastname: Helm
authors.forename: E Y
authors.initials: EY
authors.lastname: Billingsley
authors.forename: B C
authors.initials: BC
authors.lastname: Zangwill
authors.forename: R A
authors.initials: RA
authors.lastname: Schwartz
mesh_terms: D000368:Aged; D015266:Carcinoma, Merkel Cell / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery