title: The early diagnosis of periventricular leukomalacia in premature infants with positive rolandic sharp waves on serial electroencephalography.
abstract: OBJECTIVE
  The objective of this study was to determine the specificity and the sensitivity of electroencephalography's positive rolandic sharp waves (PRSW) for the diagnosis of cystic and noncystic periventricular leukomalacia (PVL).
  
  
  METHODS
  A retrospective study was performed on a population of 765 premature infants alive after 5 days who were divided into two groups; 166 infants born before 28 weeks (group 1) and 599 born between 28 and 32 completed weeks' gestation (group 2). Each infants underwent repeated ultrasound scanning and electroencephalography recordings during the first weeks of life. Magnetic resonance imaging was performed in infants with persisting hyperechoic periventricular densities on ultrasonography.
  
  
  RESULTS
  A total of 83 (10.8%) newborns had PVL; 65 (8.5%) had cystic PVL PRSW, observed in 55 (7.2%) infants, always preceded the ultrasonic detection of cysts. PRSW were very specific markers of PVL in both groups (100% in group 1, 99.8% in group 2). PRSW sensitivity was found dependent on gestational age: 32.4% in group 1 in contrast to 87.8% in group 2.
  
  
  CONCLUSIONS
  PRSW are an early and very specific marker of PVL in premature infants.
authors.affiliation: Service de Réanimation et Pédiatrie Neonatales, Hôpital Antoine Béclère, Clamart, France.
authors.forename: O
authors.initials: O
authors.lastname: Baud
authors.forename: A M
authors.initials: AM
authors.lastname: d'Allest
authors.forename: T
authors.initials: T
authors.lastname: Lacaze-Masmonteil
authors.forename: V
authors.initials: V
authors.lastname: Zupan
authors.forename: H
authors.initials: H
authors.lastname: Nedelcoux
authors.forename: C
authors.initials: C
authors.lastname: Boithias
authors.forename: J
authors.initials: J
authors.lastname: Delaveaucoupet
authors.forename: M
authors.initials: M
authors.lastname: Dehan
mesh_terms: D004569:Electroencephalography; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007969:Leukomalacia, Periventricular / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity