title: Caspases: key mediators of apoptosis.
abstract: Recent studies have established that members of the caspase protease family are essential components of a conserved cell death program. Insights into their biological roles, structure and mechanism are enabling investigators to begin to explore the therapeutic potential of caspase inhibition.
authors.affiliation: Merck Research Laboratories, Rahway, NJ 07065, USA. nancy_thornberry@merck.com
authors.forename: N A
authors.initials: NA
authors.lastname: Thornberry
mesh_terms: D000818:Animals; D017209:Apoptosis; D002384:Catalysis; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D011487:Protein Conformation; D013379:Substrate Specificity
chemical_list: D015853:Cysteine Proteinase Inhibitors; D003546:Cysteine Endopeptidases