title: Differences in plasma concentrations of the D- and L-threo methylphenidate enantiomers in responding and non-responding children with attention-deficit hyperactivity disorder.
abstract: Children with attention-deficit hyperactivity disorder who are categorized as responders or non-responders to methylphenidate (MPH) on the basis of their electrophysiological P3 response in a selective attention task differ in metabolic patterns of the D- and L-threo MPH enantiomers. Non-responders showed significantly higher plasma concentrations of both D- and L-threo MPH enantiomers.
authors.affiliation: Faculty of Social Sciences, Department of Psychonomics, Utrecht University, The Netherlands. L.Jonkman@FSW.RUU.NL
authors.forename: L M
authors.initials: LM
authors.lastname: Jonkman
authors.forename: M N
authors.initials: MN
authors.lastname: Verbaten
authors.forename: D
authors.initials: D
authors.lastname: de Boer
authors.forename: R A
authors.initials: RA
authors.lastname: Maes
authors.forename: J K
authors.initials: JK
authors.lastname: Buitelaar
authors.forename: C
authors.initials: C
authors.lastname: Kemner
authors.forename: H
authors.initials: H
authors.lastname: van Engeland
authors.forename: H S
authors.initials: HS
authors.lastname: Koelega
mesh_terms: D000704:Analysis of Variance; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000145:classification / Q000188:drug therapy / Q000503:physiopathology; D000697:Central Nervous System Stimulants / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D002648:Child; D004351:Drug Resistance; D018913:Event-Related Potentials, P300 / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007536:Isomerism; D008297:Male; D008774:Methylphenidate / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D014836:Volition / Q000187:drug effects / Q000502:physiology
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate