title: Synovial sarcoma: oncological and functional results.
abstract: OBJECTIVE
  To evaluate the oncological and functional result of the treatment of patients with a synovial sarcoma. This paper gives a retrospective review of 20 patients (15 male and five female) treated for synovial sarcoma at the Nijmegen University Hospital, The Netherlands.
  
  
  METHODS
  The median age of the patients was 30 years (range: 14-71, mean 37 years).
  
  
  RESULTS
  The tumour locations were: lower extremity in 12 patients; upper extremity in three; pelvic and groin region in four; and the retroperitoneal space in one. Surgical stages according to Enneking (Clin Orthop 1986; 204: 9-24) were IIA in five cases; IIB in seven; and IIIB in eight. The surgical margin was intralesional in three cases; marginal in three; wide in six; and radical in six. In one case the surgical margin could not be assessed and one patient was not operated. One patient developed a recurrent tumour and one developed nodal metastases. Eight patients who did not have metastases at the time of diagnosis developed metastase during follow-up. Fourteen patients died of metastatic disease; one patient died of diabetes; one is alive with disease; and four presently do not have evidence of disease.
  
  
  CONCLUSIONS
  The outcome was poor, especially due to the occurrence of pulmonary metastases. The functional result according to the MSTS was 100% in four patients; in one the result was 93% because of the scar and venous insufficiency.
authors.affiliation: Department of Orthopaedics, University Hospital, Nijmegen, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: van der Heide
authors.forename: R P
authors.initials: RP
authors.lastname: Veth
authors.forename: M
authors.initials: M
authors.lastname: Pruszczynski
authors.forename: T
authors.initials: T
authors.lastname: Wobbes
authors.forename: Q G
authors.initials: QG
authors.lastname: van Hoesel
authors.forename: J A
authors.initials: JA
authors.lastname: Lemmens
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D013584:Sarcoma, Synovial / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D016019:Survival Analysis; D016896:Treatment Outcome