Modelling cure rates using the Gompertz model with covariate information.
We extend the modified Gompertz hazard function, first used by Cantor and Shuster for estimation of cure rates from pediatric clinical trials, by including covariate effects. The extended model provides a convenient method for estimation of the cure rate as a function of treatments and covariates.
Gieser
P W
PW
Pediatric Oncology Group Statistical Office, Gainesville, FL 32601-3330, USA.
Chang
M N
MN
Rao
P V
PV
Shuster
J J
JJ
Pullen
J
J
D000465:Algorithms; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D006801:Humans; D016013:Likelihood Functions; D016014:Linear Models; D008432:Mathematical Computing; D015233:Models, Statistical; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D015996:Survival Rate; D016896:Treatment Outcome