Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules.
The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with C. immitis.
Zimmermann
C R
CR
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis 95616, USA. crzimmermann@ucdavis.edu
Johnson
S M
SM
Martens
G W
GW
White
A G
AG
Zimmer
B L
BL
Pappagianis
D
D
D000818:Animals; D003045:Coccidioides / Q000276:immunology*; D003047:Coccidioidomycosis / Q000517:prevention & control*; D005657:Fungal Vaccines / Q000276:immunology*; D007114:Immunization; D051379:Mice; D011817:Rabbits
D005657:Fungal Vaccines