title: Protection against lethal murine coccidioidomycosis by a soluble vaccine from spherules.
abstract: The formaldehyde-killed, whole-spherule vaccine, which is protective against lethal challenge of laboratory animals with Coccidioides immitis, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine. This vaccine, when it was accompanied by adjuvant, protected mice against lethal intranasal and intravenous challenge with C. immitis.
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis 95616, USA. crzimmermann@ucdavis.edu
authors.forename: C R
authors.initials: CR
authors.lastname: Zimmermann
authors.forename: S M
authors.initials: SM
authors.lastname: Johnson
authors.forename: G W
authors.initials: GW
authors.lastname: Martens
authors.forename: A G
authors.initials: AG
authors.lastname: White
authors.forename: B L
authors.initials: BL
authors.lastname: Zimmer
authors.forename: D
authors.initials: D
authors.lastname: Pappagianis
mesh_terms: D000818:Animals; D003045:Coccidioides / Q000276:immunology*; D003047:Coccidioidomycosis / Q000517:prevention & control*; D005657:Fungal Vaccines / Q000276:immunology*; D007114:Immunization; D051379:Mice; D011817:Rabbits
chemical_list: D005657:Fungal Vaccines