Antibacterial activity of dentine primer containing MDPB after curing.
OBJECTIVE
A monomer methacryloyloxydodecylpyridinium bromide (MDPB) has antibacterial activity before polymerization. Furthermore, the antibacterial agent is immobilized by the polymerization of MDPB and the resin-based material incorporating MDPB is able to show an antibacterial effect even after being cured. The purpose of this study was to investigate the antibacterial effect of a dentine primer containing MDPB after curing.


METHODS
The inhibitory effect of a cured MDPB-containing primer on the growth of Streptococcus mutans, Actinomyces viscosus and Lactobacillus casei was determined by the agar-disc method. The bactericidal activity of cured primer during a 1-h contact period was assessed using S. mutans, and the elution of unpolymerized MDPB was measured with high performance liquid chromatography.


RESULTS
Cured MDPB-containing primer showed an inhibitory effect on the growth of all species which were in contact with the specimen surface, and displayed a little bactericidal effect on S. mutans without releasing any unpolymerized antibacterial components.


CONCLUSIONS
Incorporation of antibacterial monomer MDPB into dentine primer is beneficial for providing antibacterial activity after curing.
Imazato
S
S
Department of Operative Dentistry, Osaka, University Faculty of Dentistry, Japan. imazato@dent.osaka-u.ac.jp
Ehara
A
A
Torii
M
M
Ebisu
S
S
D016924:Actinomyces viscosus / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology*; D015169:Colony Count, Microbial; D017220:Dentin-Bonding Agents / Q000737:chemistry / Q000494:pharmacology*; D007778:Lactobacillus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000737:chemistry / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D013295:Streptococcus mutans / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D017220:Dentin-Bonding Agents; D011726:Pyridinium Compounds; C089392:methacryloyloxydodecylpyridinium bromide