[The role of apoptosis of granulosa cells in follicular atresia].
Apoptosis plays an important role in the process of morphogenesis and embryogenesis. Its increase or inhibition is an etiopathological factor in many different diseases. It has recently been shown that apoptosis of granulosa cells is one of the main mechanisms responsible for follicular atresia. There are many other factors influencing the process of granulosa cells apoptosis, among them the most important are: RnGH, FSH, LH, sex hormones (estrogens and androgens), growth factors and their receptors (EGF/TGF-alpha, FGF, IGF-1) and cytokines (e.g. TNF-alpha). The article presents data concerning the regulatory mechanisms of granulosa cells apoptosis in the ovary.
Grotowski
W
W
Kliniki Endokrynologii Ginekologicznej Instytutu Ginekologii i Połoznictwa AM w Poznaniu.
Lecybył
R
R
Warenik-Szymankiewicz
A
A
Trzeciak
W H
WH
D017209:Apoptosis / Q000502:physiology*; D005260:Female; D005496:Follicular Atresia / Q000502:physiology*; D006107:Granulosa Cells / Q000502:physiology*; D006801:Humans; D010053:Ovary / Q000502:physiology*
Rola apoptozy komórek ziarnistych w procesie atrezji pecherzyków jajnikowych.