title: Interferon alpha primes early proliferative response of bone marrow cells in vivo.
abstract: Using colony-forming assays, a number of previous studies established that interferon alpha (IFN-alpha) could cause bone marrow cell (BMC) suppression. In this study, the suppressive effect of IFN-alpha is however shown to be time-dependent, occurring only 7-8 days after transfer of BMC obtained from IFN-alpha-treated mice to growth factor-containing culture medium. In contrast, in the interval before suppression is observed, BMC obtained from IFN-alpha-treated mice initially proliferated more rapidly than BMC from placebo-treated mice. These findings suggest that IFN-alpha acts in vivo to prime the proliferative responses of BMC, a hitherto unexpected action which may have clinical relevance.
authors.affiliation: University of Vienna, Institute of Applied Microbiology, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Pretnar
authors.forename: F
authors.initials: F
authors.lastname: Steindl
authors.forename: A
authors.initials: A
authors.lastname: Meager
authors.forename: R
authors.initials: R
authors.lastname: Thorpe
authors.forename: N
authors.initials: N
authors.lastname: Borth
authors.forename: C
authors.initials: C
authors.lastname: Schmatz
authors.forename: R
authors.initials: R
authors.lastname: Metzger
authors.forename: H W
authors.initials: HW
authors.lastname: Katinger
authors.forename: I
authors.initials: I
authors.lastname: Ferlan
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division; D002478:Cells, Cultured; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins; D016173:Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor