del 11(q23) as a prognostic factor of iron overload in refractory anemia with ringed sideroblasts.
We present the case of a patient with MDS RARS subtype with loss of part of the long arm of chromosome 11 del 11(q23). This a cytogenetic abnormality that occurs in 7% to 20% of RARS cases not related to poor prognosis. It seems that this deletion is a marker of iron overload in MDS.
Chauffaille
M de L
Mde L
Disciplina de Hematologia e Hemoterapia, Escola Paulista de Medicina-UNIFESP, Brazil.
Stéfano
J T
JT
Valério
R M
RM
Romeo
M
M
Rodrígues
M M
MM
Kerbauy
J
J
D000753:Anemia, Refractory / Q000235:genetics*; D000756:Anemia, Sideroblastic / Q000235:genetics*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D019190:Iron Overload / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis