Kainic acid lesions of the superior olivary complex: effects on sound localization by the albino rat.
The ability of rats to localize sounds in space was determined before and after kainic acid lesions of the superior olivary complex (SOC). Animals were tested with a 45-ms noise burst delivered from loudspeakers on the right or left of midline. Anatomical data showed that the lesions destroyed neurons in SOC while preserving fibers of passage in the trapezoid body and other decussating pathways of the auditory brainstem. Animals with either unilateral or bilateral SOC lesions were impaired in their ability to localize a single noise burst postoperatively. Deficits were also found after unilateral lesions restricted primarily to the lateral superior olive. SOC lesions resulted in an elevation in minimum audible angles for sound localization.
van Adel
B A
BA
Psychology Department, Carleton University, Ottawa, Ontario, Canada.
Kelly
J B
JB
D000818:Animals; D001306:Auditory Pathways / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D001930:Brain Injuries / Q000139:chemically induced; D001931:Brain Mapping; D001933:Brain Stem / Q000033:anatomy & histology; D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid; D008297:Male; D011149:Pons / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013017:Sound Localization / Q000502:physiology*
D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid