[Research on IgE responsiveness in asthma patients].
OBJECTIVE
To understand the relationship between IgE and asthma, and the genetic background of IgE.


METHODS
The authors measured serum total IgE in 121 healty subjects and 100 asthmatic children (CAC-IRMA) and investigated three AA families with total IgE evaluation and genetic linkage analysis between IgE and D11S533.


RESULTS
The IgE cutoff point between low and high was defined at 150 kU/L. There were 33.1% population with high level of total IgE. Of the 100 asthmatic children 96% had higher IgE level than controls, the difference was significant (P < 0.001). The IgE level of 22 asthmatic children in their releases had no significant difference compared with that in their attacks. In 40 members of three atopic asthma families, there were 23 persons with high IgE and 15 with asthma. In these families high IgE level were found both in male and female and the affected person occured in consecutive three generations, which fit to AD inheritance. Family 1 and 3 generally showed a high level of IgE, while family 2 showed low level of IgE. Two point linkage analysis between IgE and D11S533 showed that there were two recombinants from 22 meioses in the two families with a maximum lod score 1.074 at a recombination fraction of 0.05.


CONCLUSIONS
Most of asthma children have high IgE, which seems obtained from birth. About 1/3 population have high level IgE who are potential atopic persons. IgE level in human beings in inherited by AD mode. IgE gene may be close to 11q13.3-13.4.
Chen
X
X
Children's Hospital, Zhejiang Medical University, Hangzhon.
Tang
P
P
Li
Y
Y
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000235:genetics / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000235:genetics; D008297:Male; D010375:Pedigree
D007073:Immunoglobulin E