Plasma beta-carotene, retinol, and alpha-tocopherol levels in relation to glycemic control of children with insulin-dependent diabetes mellitus.
Plasma beta-carotene, alpha-tocopherol and retinol were measured in 15 female and 5 male children with insulin-dependent diabetes mellitus (IDDM), and the correlations with plasma hemoglobin A1c (HbA1c) and fructosamine were analyzed. Twelve female and 8 male children served as age-matched controls. The plasma beta-carotene and alpha-tocopherol levels of the IDDM children were significantly higher than those of the control children, but there were no differences in plasma retinol or total lipid levels. The plasma beta-carotene level, beta-carotene/retinol ratio and beta-carotene/total lipids ratio each showed significant correlations with serum HbA1c and fructosamine in all subjects studied. Similarly, the plasma alpha-tocopherol level and alpha-tocopherol/total lipids ratio were correlated with these indexes of glycemic control. These findings suggest certain mechanisms may exist to prevent lipid peroxidation and vascular complications in IDDM patients.
Hozumi
M
M
Department of Pediatrics, Osaka Medical College, Japan.
Murata
T
T
Morinobu
T
T
Manago
M
M
Kuno
T
T
Tokuda
M
M
Konishi
K
K
Mingci
Z
Z
Tamai
H
H
D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D019270:Fructosamine / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*; D019207:beta Carotene / Q000097:blood*
D001786:Blood Glucose; D019270:Fructosamine; D006442:Glycated Hemoglobin; D008055:Lipids; D014801:Vitamin A; D014810:Vitamin E; D019207:beta Carotene