Follicular mucinosis presenting as an acneiform eruption: report of four cases.
Follicular mucinosis can be a primary idiopathic disease or a secondary disease associated with lymphoma. When it appears in childhood or adolescence, it is usually primary and self-limited. We describe four cases of follicular mucinosis occurring in early adulthood that have had protracted courses. Each presented as an unusual acneiform eruption. Two of the cases demonstrated a clonal genetic rearrangement of the T-cell receptor within the cutaneous lymphoid infiltrate, a finding not previously reported. Although its significance is not clear, the clonal lymphocytic expansion indicates a need for continued surveillance of these patients.
Wittenberg
G P
GP
Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA.
Gibson
L E
LE
Pittelkow
M R
MR
el-Azhary
R A
RA
D000152:Acne Vulgaris / Q000175:diagnosis* / Q000473:pathology; D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002990:Clobetasol / Q000627:therapeutic use; D002999:Clone Cells / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D015329:Gene Rearrangement, T-Lymphocyte; D005938:Glucocorticoids; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use; D007641:Keratolytic Agents / Q000627:therapeutic use; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008911:Minocycline / Q000627:therapeutic use; D000507:Mucinosis, Follicular / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013752:Tetracycline / Q000627:therapeutic use; D014212:Tretinoin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D007641:Keratolytic Agents; D011948:Receptors, Antigen, T-Cell; D014212:Tretinoin; D002990:Clobetasol; D015474:Isotretinoin; D013752:Tetracycline; D008911:Minocycline