Synthesis and evaluation of the CNS activity of new 4-alkoxyphenylimidazolidin-2-ones.
Various 4-alkoxyphenylimidazolidin-2-ones were prepared from benzaldehydes via a Curtius rearrangement and were evaluated for their anticonvulsant activities.
Guillon
J
J
Centre d'Etudes et de Recherche sur le Médicament de Normandie, Laboratoire de Pharmacochimie, Caen, France.
Lelong
V
V
Renault
O
O
Boulouard
M
M
Dallemagne
P
P
Rault
S
S
Robba
M
M
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D005260:Female; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D007093:Imidazoles