[The action of Essentiale and its combination with cordiamine and vitamin E on the processes of xenobiotic biotransformation and lipid peroxidation and on liver structure in rats with cholestasis].
Intensive regeneration of cholangia and cholangioles, fibrosis, microglobular cirrhosis, vacuolar and granular dystrophy, and necrosis of hepatocytes were found in the liver of rats 36 days after ligation of the common bile duct. Lipid peroxidation was activated, the activity of the mono-oxidase system was inhibited in maintained function of glucuro- and glutathione transferase. Essentiale (per os in starch mucilage, 1 ml/kg. for 35 days) increased the activity of cytosol glutathione-S-transferase and normalized the decreased blood plasma antioxidant activity. Combination of essentiale with cordiamin (nikethamide) and viatmin E (50 mg/kg for 35 days) considerably activated the mono-oxigenase, glucoro- and glutathione transferase systems of the liver: the free-radical processes became less intense. The structure of the liver improves insignificantly in both methods of treatment.
Zverinskiĭ
I V
IV
Institute of Biochemistry, Belarus Academy of Sciences. Regional Clinical Hospital, Grodno.
Karpovich
V E
VE
Bushma
M I
MI
Legon'kova
L F
LF
Mel'nichenko
N G
NG
Nechiporenko
L I
LI
Nikitin
V S
VS
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001711:Biotransformation / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002779:Cholestasis / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D009552:Nikethamide / Q000627:therapeutic use*; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D051381:Rats; D014810:Vitamin E / Q000627:therapeutic use*; D015262:Xenobiotics / Q000493:pharmacokinetics*
D000975:Antioxidants; D000697:Central Nervous System Stimulants; D010713:Phosphatidylcholines; D015262:Xenobiotics; C011246:essential 303 forte; D014810:Vitamin E; D009552:Nikethamide
Deĭstvie essentsiale, ego kombinatsii s kordiaminom i vitaminom E na protsessy biotransformatsii ksenobiotikov, perekisnogo okisleniia lipidov i struktury pecheni krys s kholestazom.