title: Obstructive sleep apnea syndrome in patient with Creutzfeldt-Jakob disease. Clinical and morphological report.
abstract: We report a case of Creutzfeldt-Jakob disease (CJD) which at the beginning of the disease presented clinical syndrome of progressive supranuclear palsy. Rapid intellectual deterioration, supranuclear palsy, postural instability and myoclonic jerks suggested clinical diagnosis of CJD. After five months suffering from the disease patient developed obstructive sleep apnea syndrome (OSAS) confirmed by serial polysomnograms. OSAS is discussed in the context of the localization of histopathological findings and possible involvement of central autonomic structures. The main structures affected by spongiosis and astrogliosis were cortex, thalamus, basal ganglia and midbrain. OSAS was found as another sleep disturbance in CJD apart from insomnia and sleep-wake cycle abnormalities.
authors.affiliation: Department of Neurology, School of Medicine, Warszawa.
authors.forename: Z
authors.initials: Z
authors.lastname: Jamrozik
authors.forename: T
authors.initials: T
authors.lastname: Przybyłowski
authors.forename: B
authors.initials: B
authors.lastname: Zakrzewska-Pniewska
authors.forename: J
authors.initials: J
authors.lastname: Rafałowska
mesh_terms: D001921:Brain / Q000473:pathology; D002421:Caudate Nucleus / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000175:diagnosis; D004569:Electroencephalography; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008636:Mesencephalon / Q000473:pathology; D008875:Middle Aged; D009474:Neurons / Q000473:pathology; D017286:Polysomnography; D011699:Putamen / Q000473:pathology; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000209:etiology*