Hydrogen peroxide gas plasma sterilization is effective against Cryptosporidium parvum oocysts.
The aim of this work was to evaluate in an immunosuppressed rat cryptosporidiosis model a new method that combines vacuum and low-temperature hydrogen peroxide gas plasma for sterilization of endoscopic material contaminated by Cryptosporidium parvum. Rats were challenged with oocysts either air-dried or air-dried and treated with vacuum alone or associated with gas plasma. No rat was found infected after gas plasma exposure of oocysts, whereas vacuum or air-drying alone resulted only in a decreased infectivity.
Vassal
S
S
Laboratoire de Parasitologie Expérimentale, Centre hospitalo-universitaire of Rouen, France.
Favennec
L
L
Ballet
J J
JJ
Brasseur
P
P
D000818:Animals; D016009:Chi-Square Distribution; D003457:Cryptosporidiosis / Q000276:immunology / Q000517:prevention & control*; D016785:Cryptosporidium parvum / Q000187:drug effects* / Q000472:pathogenicity; D004195:Disease Models, Animal; D005243:Feces / Q000469:parasitology; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D016867:Immunocompromised Host; D016877:Oxidants / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013242:Sterilization / Q000379:methods*
D016877:Oxidants; D006861:Hydrogen Peroxide