Role of the matrix in autosomal dominant polycystic kidney disease.
At present, even though we have accumulated a wealth of knowledge regarding structural, and molecular changes in ADPKD, the primary cause of the disease remains unknown. Obviously the gap in our understanding of the nature of the disease has been narrowed substantially over the past decade. With current techniques and efforts, the ultimate mystery of ADPKD should be resolved during the next decade.
Carone
F A
FA
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611-3008, USA.
Bacallao
R
R
Kanwar
Y
Y
D005109:Extracellular Matrix / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010641:Phenotype; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D050396:TRPP Cation Channels
D016326:Extracellular Matrix Proteins; D011506:Proteins; D050396:TRPP Cation Channels