title: Isoniazid-induced pure red cell aplasia in two siblings.
abstract: Pure red cell aplasia (PRCA) is a rare complication of treatment with isoniazid mainly observed in adults. We report two siblings who had anemia caused by PRCA during administration of isoniazid. On discontinuation of isoniazid, the anemia resolved rapidly. PRCA should be considered as a possible cause of unexplained anemia during isoniazid therapy in children.
authors.affiliation: Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Italy.
authors.forename: G L
authors.initials: GL
authors.lastname: Marseglia
authors.forename: F
authors.initials: F
authors.lastname: Locatelli
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid