title: Pyrimidine antagonists and antifolates as antimalarial drugs.
authors.affiliation: Department of Biochemistry, University of Sydney, NSW, Australia.
authors.forename: R I
authors.initials: RI
authors.lastname: Christopherson
authors.forename: K K
authors.initials: KK
authors.lastname: Seymour
authors.forename: A E
authors.initials: AE
authors.lastname: Yeo
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000633:toxicity*; D003622:Dapsone / Q000494:pharmacology; D003854:Deoxyribonucleotides / Q000378:metabolism*; D018432:Drug Resistance, Multiple; D004791:Enzyme Inhibitors / Q000633:toxicity*; D005493:Folic Acid Antagonists / Q000633:toxicity*; D009963:Orotic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000378:metabolism; D002727:Proguanil / Q000494:pharmacology; D011743:Pyrimidines / Q000037:antagonists & inhibitors; D012265:Ribonucleotides / Q000378:metabolism*
chemical_list: D000962:Antimalarials; D003854:Deoxyribonucleotides; D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D012265:Ribonucleotides; C066572:6-thiodihydroorotate; D009963:Orotic Acid; D003622:Dapsone; D002727:Proguanil