Immunosuppressive and antiparasitic effects of cyclosporin A on Hymenolepis nana infection in mice.
The effect of cyclosporin A, which is known to act both as immunosuppressant and as an antiparasitic drug in many host-parasite systems, was examined in a mouse-Hymenolepis nana system. When BDF1 mice were injected s.c. with cyclosporin A (100 mg kg-1 day-1) every 48 h from 11 days p.i. with eggs, expulsion of the adult worms from the intestines of mice was prevented completely until at least 30 days p.i. Worm burden, dry weight and the number of gravid proglottids were not significantly reduced. By contrast, in untreated mice most of the worms were eliminated by 19 days p.i. The drug also completely abolished acquired resistance to a challenge infection with eggs when mice were injected s.c. with cyclosporin A (100 mg kg-1 day-1) around the time of challenge infection (Days -2, -1, 0, 1 and 2 relative to challenge). Such immunosuppressive effects of cyclosporin A on worm expulsion and protective immunity to reinfection were similar to those of another immunosuppressant, cyclophosphamide. As for the antiparasitic action of cyclosporin A against H. nana, a smaller number of cysticercoids developed from eggs in mice given cyclosporin A (100 mg kg-1 day-1) for 5 days beginning 1 day before infection, than in untreated controls.
Matsuzawa
K
K
Department of Medical Biology, School of Medicine, Showa University, Tokyo, Japan.
Nakamura
F
F
Abe
M
M
Okamoto
K
K
D000818:Animals; D000923:Anticestodal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology; D016572:Cyclosporine / Q000008:administration & dosage / Q000494:pharmacology*; D006790:Host-Parasite Interactions; D006925:Hymenolepiasis / Q000188:drug therapy / Q000276:immunology* / Q000469:parasitology*; D006926:Hymenolepis / Q000187:drug effects* / Q000254:growth & development; D007110:Immunity, Active / Q000187:drug effects; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008018:Life Cycle Stages; D008297:Male; D051379:Mice; D010270:Parasite Egg Count; D013997:Time Factors
D000923:Anticestodal Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide