Mapping of selective rat chromosome regions using mouse microsatellite markers.
Four hundred eighty mouse microsatellite markers distributed in discrete regions on five mouse chromosomes were screened for producing PCR products in the rat. Ninety-eight of these markers or 20% give distinctive PCR products. Among these ninety-eight markers, twenty-three are polymorphic between the inbred hypertensive Dahl salt-sensitive (S) rat strain and several normotensive rat strains of interest. Fourteen of these polymorphic markers have been mapped to the homologous chromosome regions of the rat, and have further been utilized to localize quantitative trait loci (QTL) for blood pressure in the S rat.
Deng
A Y
AY
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699-0008, USA. adeng@vortex.mco.edu
Rapp
J P
JP
D000818:Animals; D001794:Blood Pressure / Q000235:genetics*; D002874:Chromosome Mapping; D008040:Genetic Linkage; D006973:Hypertension / Q000235:genetics; D051379:Mice; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D019655:Quantitative Trait, Heritable; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D013045:Species Specificity