T lymphocyte differentiation in the periphery.
The development of immune responses is significantly influenced by emerging patterns of cytokine expression in activated CD4+ T cells. Recent efforts have clarified both cellular and molecular mechanisms, and within the past year include significant observations on potential sources of IL-4 leading to Th2 development against certain pathogens, and insights into early responses and genetic susceptibility to experimental murine Leishmaniasis and transcriptional regulation of the IL-4 locus. Advances in Th1 development have included greater understanding of IL-12 receptors in Th1 development, data regarding IFN-gamma gene expression and clarification of the action of the new cytokine IL-18.
Murphy
K M
KM
Howard Hughes Medical Institute, Washington University School of Medicine, Pathology Department, St Louis, MO 63110, USA. murphy@immunology.wustl.edu
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology; D020382:Interleukin-18; D015847:Interleukin-4 / Q000235:genetics / Q000502:physiology; D051379:Mice; D018123:Receptors, Interleukin / Q000502:physiology; D053707:Receptors, Interleukin-12; D013601:T-Lymphocytes / Q000166:cytology*; D018417:Th1 Cells / Q000166:cytology; D018418:Th2 Cells / Q000166:cytology
D016207:Cytokines; D020382:Interleukin-18; D018123:Receptors, Interleukin; D053707:Receptors, Interleukin-12; D015847:Interleukin-4; D007371:Interferon-gamma