[In vitro activities of faropenem against clarithromycin resistance Helicobacter pylori isolates].
Agar dilution and semi-solid agar dilution were used to determine the MIC of faropenem (FRPM) against 24 H. pylori isolates. FRPM was active against clarithromycin resistance H. pylori isolates. And, the MICs obtained by both methods were in agreement. The results suggest that FRPM was not affected by pH and is a clinically useful oral antibiotic for the eradication therapy of H. pylori infections.
Hasegawa
M
M
Chemotherapy Division, Mitsubishi Kagaku Bio Clinical Laboratories.
Saika
T
T
Matsuzaki
K
K
Kobayashi
I
I
Fujioka
T
T
Nasu
M
M
Saionji
K
K
Igari
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D007769:Lactams; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D007769:Lactams; D047090:beta-Lactams; C107057:fropenem; D017291:Clarithromycin