Dragmacidins: new protein phosphatase inhibitors from a southern australian deep-water marine sponge, spongosorites sp
A Spongosorites sp. collected during trawling operations off the southern coast of Australia returned the new alkaloid dragmacidin E (3), the structure of which was secured by detailed spectroscopic analysis. Dragmacidin E (3), and its co-metabolite dragmacidin D (1) have been identified as potent inhibitors of serine-threonine protein phosphatases.
Capon
RJ
Department of Chemistry, University of Melbourne, Parkville, Victoria 3052, Australia, Faculty of Medicine, The University of Newcastle, University Drive, Callaghan, New South Wales 2308, Australia, and Queensland Pharmaceutical Resea.
Rooney
F
Murray
LM
Collins
E
Sim
ATR
Rostas
JAP
Butler
MS
Carroll
AR