Effects of increasing doses of alpha-tocopherol in providing protection of low-density lipoprotein from oxidation.
In this study, we tested whether 1,200 IU/day of alpha-tocopherol was more potent than 400 and 800 IU of alpha-tocopherol in decreasing low-density lipoprotein (LDL) oxidative susceptibility in a 2-month study. The decrease in LDL oxidation was significantly greater with 1,200 IU/day than 400 IU/day.
Fuller
C J
CJ
Center for Human Nutrition and the Department of Pathology, The University of Texas Southwestern Medical Center, Dallas 75235-9072, USA.
Huet
B A
BA
Jialal
I
I
D000975:Antioxidants / Q000008:administration & dosage*; D001204:Ascorbate Oxidase / Q000097:blood; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000097:blood / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D014810:Vitamin E / Q000008:administration & dosage*; D019207:beta Carotene / Q000097:blood
D000975:Antioxidants; D008077:Lipoproteins, LDL; D019207:beta Carotene; D014810:Vitamin E; D001204:Ascorbate Oxidase