Agelasines H and I, 9-methyladenine-containing diterpenoids from an Agelas sponge.
Two new diterpenes possessing a 9-methyladeninium substituent, agelasines H (5) and I (6), along with five related known ones, 1-4 and 7, were isolated from a sponge, Agelas sp. The structures of the new compounds were determined from spectral data. Compounds 2-4, 6, and 7 exhibited varying degrees of antimicrobial activity.
Fu
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Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
Schmitz
F J
FJ
Tanner
R S
RS
Kelly-Borges
M
M
D000225:Adenine / Q000031:analogs & derivatives; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004224:Diterpenes; C112377:agelasine H; C112378:agelasine I; D000225:Adenine