title: Fragments of amyloid beta induce apoptosis in vascular endothelial cells.
abstract: Injury to cells that was triggered by fragments of amyloid beta protein (A beta) was studied in human vascular endothelial cells. A fragment of A beta containing amino acids 25-35 promoted cell death, but fragments of A beta containing amino acids 31-35 and 35-25 did not have such an effect. The fragment of A beta containing amino acids 25-35 induced cell death that was characterized as programmed cell death (apoptosis) in view of the accompanying morphological changes, the fragmentation of DNA, and the requirement for protein synthesis.
authors.affiliation: Sugashima Marine Biological Laboratory, School of Science, Nagoya University, Toba, Mie, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hase
authors.forename: S
authors.initials: S
authors.lastname: Araki
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006801:Humans; D010446:Peptide Fragments / Q000494:pharmacology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D015398:Signal Transduction; D014471:Umbilical Veins
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D011500:Protein Synthesis Inhibitors; C078592:amyloid beta-protein (1-40); C074636:amyloid beta-protein (25-35); C113042:amyloid beta-protein (31-35); C113041:amyloid beta-protein (35-25); D005346:Fibroblast Growth Factors; D003513:Cycloheximide