title: Measuring the thermodynamics of RNA secondary structure formation.
abstract: The thermodynamics of RNA secondary structure formation in small model systems provides a database for predicting RNA structure from sequence. Methods for making these measurements are reviewed with emphasis on optical methods and treatment of experimental errors. Analysis of experimental results in terms of simple nearest-neighbor models is presented. Some measured sequence dependences of non-Watson-Crick motifs are discussed.
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
authors.forename: J
authors.initials: J
authors.lastname: SantaLucia
authors.forename: D H
authors.initials: DH
authors.lastname: Turner
mesh_terms: D001482:Base Composition; D001483:Base Sequence; D002151:Calorimetry; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D055095:Optics and Photonics; D012313:RNA / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D012313:RNA