[DNA quantitative analysis of small bowel carcinoma and its clinical significance].
By using computer cytophotometric analysis, aneuploid as well as other 12 parameters of tissue DNA content were measured in 28 cases of small bowel cancer, 5 cases of intestinal adenoma, 6 cases of normal intestinal tissues. The number of aneuploid tumors in intestinal cancer was much higher than in intestinal adenoma. 7 DNA parameters (Entropy of DNA, 2CDI, DNA- grade of neoplasia, 5C Exceeding Rate, 9C Exceeding Rate, Diploid Deviation Quotient and Mean Ploidy) were the valuable indexes that could determine the quality of intestinal lesions, benign or malignant. DNA content didn't correlate with the clinically differentiated degree of pathological tissues, but aneuploid intestinal cancers had a higher malignant degree than non-aneuploid ones, and were more liable to invade and metastasize with low postoperative survival-rate and poor prognosis. 5 DNA parameters (DNA-Index, Medal Value, DNA-grade of neoplasia, Stemline Ploid and 9C Exceeding Rate) had close relation to the prognosis of intestinal cancer, possessing important value to the prognostic analysis of intestinal cancer.
Ge
C
C
Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyan.
He
S
S
Tian
Y
Y
D000236:Adenoma / Q000235:genetics / Q000601:surgery; D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002277:Carcinoma / Q000235:genetics* / Q000601:surgery; D004273:DNA, Neoplasm / Q000235:genetics*; D004379:Duodenal Neoplasms / Q000235:genetics* / Q000601:surgery; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000235:genetics / Q000601:surgery; D007091:Image Processing, Computer-Assisted; D007580:Jejunal Neoplasms / Q000235:genetics / Q000601:surgery; D008297:Male; D008875:Middle Aged
D004273:DNA, Neoplasm