Evidence that GABA augmentation of norepinephrine release is mediated by interneurons.
GABAA receptor activation augments stimulated release of 3H-norepinephrine (NE) in brain slices from female rats. This effect is not blocked by acetazolamide or MK-801, indicating that permeability of the GABAA chloride channel to bicarbonate ions and NMDA receptor activation do not mediate GABA-induced NE release. Furthermore, GABA augments 3H-NE release from slices, but not from isolated nerve terminals (synaptosomes), indicating that interneurons mediate GABA effects on 3H-NE release.
Fiber
J M
JM
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Etgen
A M
AM
D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D005260:Female; D005625:Frontal Lobe / Q000166:cytology / Q000378:metabolism; D007395:Interneurons / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D016202:N-Methylaspartate / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D009924:Organ Culture Techniques; D011301:Preoptic Area / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000502:physiology; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000927:Anticonvulsants; D018690:Excitatory Amino Acid Agonists; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D016202:N-Methylaspartate; D000086:Acetazolamide; D009638:Norepinephrine