Lipoprotein(a) inhibits lipopolysaccharide-induced tumor necrosis factor alpha production by human mononuclear cells.
Lipoproteins can bind lipopolysaccharide (LPS) and decrease LPS-stimulated cytokine production. Lipoprotein(a) [Lp(a)] was as potent as low-density lipoproteins (LDL) in inhibiting LPS-stimulated tumor necrosis factor synthesis by human mononuclear cells. The kinetics of LPS inhibition by Lp(a) was similar to that of LDL. This suggests that circulating Lp(a) may be an important factor determining the amplitude of the response to LPS in humans.
Netea
M G
MG
Department of Medicine, University Hospital Nijmegen, The Netherlands.
de Bont
N
N
Demacker
P N
PN
Kullberg
B J
BJ
Jacobs
L E
LE
Verver-Jansen
T J
TJ
Stalenhoef
A F
AF
Van der Meer
J W
JW
D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors*; D017270:Lipoprotein(a) / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D008070:Lipopolysaccharides; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; D014409:Tumor Necrosis Factor-alpha