Increased expression of adhesion molecule CD18 (LFA-1beta) on the leukocytes of peripheral blood in patients with acute ischemic stroke.
OBJECTIVE
The aim of this study was to investigate whether adhesion molecules play a role in acute ischemic stroke.


METHODS
Using immunofluorescence phenotyping and flow cytometry, the expression of leukocyte adhesion molecules CD54, CD11a, CD11b and CD18 in peripheral blood were measured within 12 h after onset of ischemia in 20 patients with stroke. Follow-up measurements were performed at 7 and 30 days after ictus.


RESULTS
CD18 immunofluorescence was significantly increased on the leukocytes within 12 h after onset in patients with stroke compared with the age-matched control group (20 patients with other neurological diseases). Follow-up measurement of CD18 revealed normal results as found in the control group.


CONCLUSIONS
Our data support the idea that adhesion molecules are involved in tissue injury in ischemic stroke.
Fiszer
U
U
Institute of Psychiatry and Neurology, Warsaw, Poland.
Korczak-Kowalska
G
G
Palasik
W
W
Korlak
J
J
Górski
A
A
Członkowska
A
A
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002545:Brain Ischemia / Q000097:blood* / Q000145:classification; D018845:CD11 Antigens / Q000032:analysis; D018821:CD18 Antigens / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D006098:Granulocytes / Q000737:chemistry; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D007958:Leukocyte Count; D007962:Leukocytes / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
D018845:CD11 Antigens; D018821:CD18 Antigens; D018799:Intercellular Adhesion Molecule-1