[Molecular mechanisms of autorepair of DNA double strand breaks].
The physical mechanism of interaction between nucleotides in intracellular liquid medium was studied. It was shown that during the contact between the thymine and guanine there exists a potential barrier the distance of about 10 A, which prevents the enzyme self-repairing in DNA after a double damage. All the remaining pairs of nucleotides have no such a barrier. Some processes of self-repairing of DNA for various types of double damages are analyzed. The geometry of an irreversible damage of DNA was determined. It was shown that with the increase in the number of hydrated electrons diminishing of the viscosity and increase in the temperature of intracellular medium the barrier vanishes and DNA undergoes a complete self-repairing.
Vysotskiĭ
V I
VI
Shevchenko Kiev University.
Kornilova
A A
AA
Samoĭlenko
I I
II
D002477:Cells; D004249:DNA Damage; D053938:DNA Fragmentation; D004260:DNA Repair; D004583:Electrons; D009711:Nucleotides; D011836:Radiation Tolerance; D014783:Viscosity
D009711:Nucleotides
Molekuliarnye mekhanizmy samoreparatsii dvoĭnykh razryvov DNK.