Leukemogenesis: small differences in Myb have large effects.
The avian retroviruses E26 and AMV carry mutated versions of the gene encoding the cellular transcription factor c-Myb. Surprisingly, these two mutant forms of Myb differ in the subsets of myeloid cells that they transform, the target genes that they activate, and the way in which they are regulated.
Graf
T
T
EMBL, Heidelberg, Germany. graf@embl-heidelberg.de
D000818:Animals; D009189:Avian Myeloblastosis Virus / Q000235:genetics; D002352:Carrier Proteins / Q000378:metabolism; D002454:Cell Differentiation; D002472:Cell Transformation, Viral; D000081406:Peptidyl-Prolyl Isomerase F; D021983:Cyclophilins; D005786:Gene Expression Regulation; D005822:Genetic Vectors; D009154:Mutation; D019696:Peptidylprolyl Isomerase / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism*; D020598:Proto-Oncogene Proteins c-myb; D012190:Retroviridae / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism*
D002352:Carrier Proteins; D000081406:Peptidyl-Prolyl Isomerase F; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D015534:Trans-Activators; D021983:Cyclophilins; D019696:Peptidylprolyl Isomerase