Synthesis and properties of carbocyclic oligothymidylate lacking the 5'-methylene.
Oligodeoxynucleotides possessing a shortened internucleotidic linkage have been prepared using carbocyclic nucleosides lacking the 5'-methylene as the monomeric units. Specifically, the oligomers derived from carbocyclic 5'-n or thymidine and 2'-hydroxy-3'-deoxythymidine will be described.
Koga
M
M
Department of Applied Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Japan.
Yamamoto
M
M
Nishi
T
T
Endo
Y
Y
Suzuki
T
T
Saeki
T
T
D007202:Indicators and Reagents; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013936:Thymidine / Q000031:analogs & derivatives*
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; C027903:oligo (dT); D013936:Thymidine