Advances in periodontal diagnosis. 5. Potential inflammatory and immune markers.
The potential inflammatory and immune markers that might detect periodontal disease severity or activity are examined. The role of inflammatory and immune factors passing from the tissues into the gingival crevicular fluid (GCF) are considered. GCF sampling is a necessary part of all diagnostic tests based on gingival and periodontal tissue factors. Inflammatory and immune factors found in GCF are reviewed with special reference to the humoral immune response, complement, cytokines and prostaglandins. The possible development of diagnostic tests based on these factors are discussed.
Eley
B M
BM
Periodontal Department, King's College School of Medicine and Dentistry, Denmark Hill, London.
Cox
S W
SW
D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation / Q000276:immunology; D001095:Arachidonic Acids / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D016207:Cytokines / Q000032:analysis; D015232:Dinoprostone / Q000032:analysis; D005883:Gingival Crevicular Fluid / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007155:Immunologic Factors / Q000032:analysis*; D018836:Inflammation Mediators / Q000032:analysis*; D007378:Interleukins / Q000032:analysis; D010510:Periodontal Diseases / Q000175:diagnosis* / Q000276:immunology; D011453:Prostaglandins / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000906:Antibodies; D001095:Arachidonic Acids; D016207:Cytokines; D007136:Immunoglobulins; D007155:Immunologic Factors; D018836:Inflammation Mediators; D007378:Interleukins; D011453:Prostaglandins; D014409:Tumor Necrosis Factor-alpha; D003165:Complement System Proteins; D015232:Dinoprostone