Cosegregation of the Tnfalpha locus with cardiovascular phenotypes in the F2 generation of a New Zealand genetically hypertensive and Brown Norway cross.
1. The association of the Tnfalpha locus with several cardiovascular phenotypes and body mass has been studied in the F2 generation of a reciprocal cross between rats of the New Zealand genetically hypertensive (GH) and the normotensive Brown Norway (BN) strains. In the total F2 population the GH allele of Tnfalpha cosegregated with increased intra-arterial blood pressure (BP) in a recessive manner. A similar but weaker effect was observed for tail BP. 2. An association between genotype and body mass in females with GH grandfathers was also detected. 3. An association between genotype and pulse rate was observed for females. 4. This work supports other evidence pointing to an association of a gene (or genes) on rat chromosome 20 with hypertension.
Harris
E L
EL
Department of Surgery and Centre for Gene Research, University of Otago, Dunedin, New Zealand. jean.harris@stonebow.otago.ac.nz
Grigor
M R
MR
Thompson
C M
CM
D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006973:Hypertension / Q000235:genetics*; D008297:Male; D010641:Phenotype; D051381:Rats; D011914:Rats, Inbred BN / Q000235:genetics; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D005819:Genetic Markers; D014409:Tumor Necrosis Factor-alpha