A clinical and histological comparative study of the effect of nifedipine and phenytion on human gingiva.
Ten patients manifesting gingival enlargement were chosen for this study. Five patients had been treated with 4 mg nifedipine per day as a treatment for angina pectoris, while the other five patients treated with phenytion as an anticonvulsant drug. Clinical and histological data showed that nefidipine induced gingival hyperplasia which is of close similarity to that induced by phenytion despite the differences in target tissue.
Shoieb
M A
MA
Faculty of Oral and Dental Medicine, Cairo University, Egypt.
Fathy
L M
LM
Abu-el-Dahab
O
O
el-Sherbiny
M M
MM
D000927:Anticonvulsants / Q000009:adverse effects*; D001706:Biopsy; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D005881:Gingiva / Q000187:drug effects* / Q000473:pathology; D005885:Gingival Hyperplasia / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D009543:Nifedipine / Q000009:adverse effects*; D010672:Phenytoin / Q000009:adverse effects*; D013997:Time Factors
D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D010672:Phenytoin; D009543:Nifedipine