Oligonucleotide synthesis by the use of a 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBZ) group for the 5'-hydroxyl group of ribonucleoside and 2'-deoxyribonucleoside 3'-phosphoramidites.
Synthetic studies on the CpCpA terminus triplet, whose exocyclic amino groups are all labeled with 15N, and a phosphorodithioate-linked oligonucleotide in terms of 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) group as the novel base-labile protecting group for the 5'-hydroxyl groups of nucleoside 3'-phosphoramidites, are described.
Kamaike
K
K
Laboratory of Pharmaceutical Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Takahashi
H
H
Kakinuma
T
T
Morohoshi
K
K
Ishido
Y
Y
D007202:Indicators and Reagents; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds; D013873:Thionucleotides
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009843:Oligoribonucleotides; D009943:Organophosphorus Compounds; D013873:Thionucleotides