[The change of serotonin of venous blood in pregnancy induced hypertension].
OBJECTIVE
To provide evidence to the hypothesis that the involvement of serotonin (5-HT) takes part in the pathogenesis of pregnancy induced hypertension (PIH).


METHODS
31 pregnant women with PIH and 20 normotensive pregnant women were studied in the present study. Venous plasma 5-HT and platelet 5-HT from all subjects were measured with spectrometry.


RESULTS
The mean platelet 5-HT level in PIH group (24.69 +/- 17.79 micrograms/L) was less than that in normotensive group (91.06 +/- 47.77 micrograms/L) (P < 0.01). The mean plasma 5-HT level in PIH group (48.65 +/- 19.29 micrograms/L) was significantly higher than that in normotensive group (35.39 +/- 12.88 micrograms/L) (P < 0.01).


CONCLUSIONS
Plasma levels of 5-HT in PIH were elevated significantly, this might be largely caused by the increased release of 5-HT by platelet. The results show that elevated level of 5-HT in patients with PIH might take part in the pathogenesis of PIH.
Ren
D
D
General Hospital of Air Force PLA, Beijing.
Yang
M
M
Luo
Y
Y
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology; D011247:Pregnancy; D012701:Serotonin / Q000097:blood*; D013050:Spectrometry, Fluorescence
D012701:Serotonin