title: Plasma thromboxane B2 concentration in patients with ventricular septal defect and pulmonary hypertension.
abstract: Plasma thromboxane B2 (TXB2)-a stable metabolite of thromboxane A2 (TXA2)-conventional hemodynamic parameters, mean pulmonary input energy (input energy), and mean pulmonary output energy (output energy) were measured to assess platelet activation in 21 patients with pulmonary hypertension and a ventricular septal defect (VSD). The patients were divided into 2 groups: group A (normal range) and group B (high level). TXB2 levels were measured by radioimmunoassay. There was no relationship between plasma TXB2 concentrations and conventional hemodynamic parameters except the pulmonary-to-systemic pressure ratio. Output-to-input energy ratio was correlated logarithmically with the plasma TXB2 concentration. We concluded that patients with output/input energy ratio >0.15 had a high TXB2 concentration and activated platelets in pulmonary capillaries.
authors.affiliation: Department of Pediatrics, Sapporo Medical University School of Medicine, Hokkaido, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fuse
authors.forename: H
authors.initials: H
authors.lastname: Tomita
authors.forename: S
authors.initials: S
authors.lastname: Chiba
mesh_terms: D001794:Blood Pressure; D002675:Child, Preschool; D006345:Heart Septal Defects, Ventricular / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D007223:Infant; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000097:blood*
chemical_list: D013929:Thromboxane B2