title: [Radioadaptive response in lymphocytes of children living in territories polluted by radionuclides as a result of the accident at the Chernobyl power plant].
abstract: The radioadaptive response and antimutagenic action of lymphoblastoid interferon in the human blood lymphocytes of the children from polluted after Chernobyl accident Bryansk region were studied. Cells pretreated with tritiated thymidine with 2 Gy of gamma-rays at 20 h of culture after PHA-stimulation on seven of the ten donors result in lack of radioadaptive response. On testing some of them (4 donors) no protective adaptive response was found, others (3 donors) pretreated with tritiated thymidine gave sensibilization. Significant decrease in interferon antimutagenic activity in lymphocytes with disturbed adaptive response was also found. It has been proposed that there is similarity or identity of mechanism of radioadaptive response and of non-repair component of interferons antimutagenic action.
authors.affiliation: Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow.
authors.forename: G P
authors.initials: GP
authors.lastname: Makedonov
authors.forename: L V
authors.initials: LV
authors.lastname: Tskhovrebova
authors.forename: S V
authors.initials: SV
authors.lastname: Unzhakov
authors.forename: A N
authors.initials: AN
authors.lastname: Semiachkina
authors.forename: I M
authors.initials: IM
authors.lastname: Vasil'eva
authors.forename: G D
authors.initials: GD
authors.lastname: Zasukhina
mesh_terms: D000222:Adaptation, Physiological; D016587:Antimutagenic Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D002648:Child; D002869:Chromosome Aberrations; D004260:DNA Repair; D005720:Gamma Rays; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008214:Lymphocytes / Q000528:radiation effects*; D011210:Power Plants; D018788:Radioactive Hazard Release; D011848:Radioactive Pollutants / Q000009:adverse effects*; D014455:Ukraine
chemical_list: D016587:Antimutagenic Agents; D011848:Radioactive Pollutants; D007372:Interferons
vernacular_title: Radioadaptivnyĭ otvet v limfotsitakh deteĭ prozhivaiushchikh na territoriiakh, zagriaznennykh radionuklidami v rezultate avarii na Chernobyl'skoĭ AES.