title: Cellular immuno-competence of infected root canal contents in pathogenesis of periapical lesions.
abstract: The soluble fractions of infected root canal contents (IRCC) were collected from about 300 human extracted teeth and examined for the presence of mononuclear cell (MNC) chemotaxis and cellular immunocompetence. IRCC showed remarkable chemotactic activity for polymorphonuclear leukocytes but a weak activity for MNC. However, generation of intrinsic MNC chemotaxis and induction of cellular immunity were confirmed in rats given repeated injections of IRCC.
authors.affiliation: Department of Endodontology and Periodontology, Hiroshima University School of Dentistry, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Ninomiya
authors.forename: K
authors.initials: K
authors.lastname: Nakanishi
authors.forename: T
authors.initials: T
authors.lastname: Takemoto
authors.forename: T
authors.initials: T
authors.lastname: Higashi
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: H
authors.initials: H
authors.lastname: Yoshino
authors.forename: M
authors.initials: M
authors.lastname: Hirakawa
authors.forename: H
authors.initials: H
authors.lastname: Shiba
authors.forename: F
authors.initials: F
authors.lastname: Hino
authors.forename: K
authors.initials: K
authors.lastname: Shibata
authors.forename: T
authors.initials: T
authors.lastname: Hino
mesh_terms: D000818:Animals; D002634:Chemotaxis, Leukocyte; D017077:Culture Media, Conditioned / Q000494:pharmacology; D003788:Dental Pulp Diseases / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010483:Periapical Diseases / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D017077:Culture Media, Conditioned