[The effect of Gynostemma pentaphyllum mak (GP) on carcinogenesis of the golden hamster cheek pouch induced by DMBA].
The purpose of the study is to examine the effect of GP during carcinogenesis of the golden hamster cheek pouches induced by DMBA. The results indicated that epithelial olysplasia and carcinoma in situ appeared respectively at 3 and 6 weeks. The formation of carcinoma was detected as early as 4 weeks which is earlier than that of former reports. The experiment proves that GP has positive anticarcinogenic function. Long-term observation in those the DMBA has been applied for 3 weeks found that epithelial dysplasia could reverse when GP was given. A compound prescription is better than GP alone.
Zhou
Z
Z
School of Stomatology, Shanghai Second Medical University, Shanghai.
Wang
Y
Y
Zhou
Y
Y
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000139:chemically induced / Q000517:prevention & control*; D006224:Cricetinae; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007972:Leukoplakia, Oral / Q000139:chemically induced / Q000517:prevention & control; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000517:prevention & control*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D015127:9,10-Dimethyl-1,2-benzanthracene