[The roles of Kupffer cell (KC) in reduction of post burn catabolism in early enteral feeding].
This study aimed to know the roles of Kupffer cells in post burn catabolism. Rats sustained with 30% III degrees flame burns of TBSA were divided randomly into early feeding (EF) group given gastroenteral feeding beginning from 2 hours postburn (n = 45), and delayed feeding (DF) group given the same nutritional solutions but starting on PBD3 (n = 45). Another 15 rats were served as normal controls (NS) without burning. The results showed that the bowel-barrier-function reduced obviously, the thickness of mucosa and height of villi of jujunum declined significantly and the plasma endotoxin level was higher in the DF group than that in the EF group. There were obvious increase of catabolic hormone (cortisol) level and decrease of anabolic hormone (insulin) level in plasma of the DF group than that of the EF group. The protein contents of jejunum mucosa and gastrocnemius decreased significantly, TNF and PGE2 released by KCs also increased more markedly in the DF group than that in the EF group. In conclusion. KCs may play one of the key roles in the "gut derived hypermetabolism". Early enteral feeding can enhance the barrier function of intestinal mucosa and prevent the translocation of endotoxin from gut to blood stream in some extent. Early enteral feeding can reduce catabolism via the modulation of hyperactivity of Kcs and the decrease of excessive secretion of catabolic hormones.
Zhu
Y
Y
Burn Institute, South-Western Hospital, Third Military University, Chongqing.
You
Z
Z
Wang
S
S
D000818:Animals; D002056:Burns / Q000378:metabolism* / Q000473:pathology; D015232:Dinoprostone / Q000378:metabolism; D004731:Endotoxins / Q000097:blood; D004750:Enteral Nutrition; D005260:Female; D007728:Kupffer Cells / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha; D015232:Dinoprostone