Molecular cloning and expression of an avian rab5 homolog.
A chicken rab5 cDNA was isolated that contains the complete open reading frame for a protein of 216 amino acids, which, by comparison with available rab5 sequences from other species, is most closely related to the rab5c isoform. Two rab5 transcripts of 1.3 and 1.8 kb were detectable in various chicken tissues; they are abundant in tissues with high endocytic activity, such as brain, ovary, and testis. Similarly, high levels of rab5 protein expression were found in endocytotically active tissues and were increased upon estrogen treatment of roosters.
Bojer
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CD
Department of Molecular Genetics, University and Biocenter Vienna, Dr. Bohr-Gasse 9/2, A-1030 Vienna, Austria.
Wohlrab
F
F
Ivessa
N E
NE
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002645:Chickens; D003001:Cloning, Molecular; D018076:DNA, Complementary; D004967:Estrogens / Q000502:physiology; D019204:GTP-Binding Proteins / Q000235:genetics*; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D020696:rab5 GTP-Binding Proteins
D018076:DNA, Complementary; D004967:Estrogens; D019204:GTP-Binding Proteins; D020696:rab5 GTP-Binding Proteins