Antimalarial naphthoquinones from Nepenthes thorelii.
Roots of Nepenthes thorelii yielded plumbagin, 2-methylnaphthazarin, octadecyl caffeate, isoshinanolone, and droserone. In addition, seven derivatives were prepared from plumbagin. Each of these natural and semisynthetic compounds was evaluated for in vitro antimalarial potential.
Likhitwitayawuid
K
K
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. lkittisa@netserv.chula.ac.th
Kaewamatawong
R
R
Ruangrungsi
N
N
Krungkrai
J
J
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018517:Plant Roots; D010963:Plasmodium falciparum / Q000187:drug effects
D000962:Antimalarials; D009285:Naphthoquinones; D010936:Plant Extracts