Bcl-2 and Bax protein expression in neurofibrillary tangles in progressive supranuclear palsy.
Double-labeling immunohistochemistry to Bcl-2 and Bax and to tau protein was examined in the brains of patients with progressive supranuclear palsy (PSP) to study the possible relationship between the expression of Bax and Bcl-2 proteins and neurofibrillary tangle formation. No differences between Bcl-2 and Bax immunoreactivity in neurons of the brain stem were observed in PSP patients and controls. Moreover, the intensity of Bcl-2 and Bax immunoreactivity was similar in tangle-bearing and non-tangle-bearing neurons in PSP patients. These results suggest that Bcl-2 and Bax are probably not implicated in neurofibrillary tangle formation in PSP.
Tortosa
A
A
Departament d'Infermeria Médico-Quirúrgica, Universitat de Barcelona,Spain.
Blanco
R
R
Ferrer
I
I
D016022:Case-Control Studies; D006801:Humans; D007150:Immunohistochemistry; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D013494:Supranuclear Palsy, Progressive / Q000378:metabolism*; D051028:bcl-2-Associated X Protein
C494826:BAX protein, human; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein