title: Protein C in the treatment of coagulopathy in meningococcal disease.
abstract: OBJECTIVE
  To evaluate the clinical and laboratory effects of the substitution of protein C (PC) as an adjunct to conventional therapy in the treatment of purpura fulminans associated with meningococcal sepsis.
  
  
  METHODS
  case series.
  
  
  METHODS
  Medical and medical-surgical intensive care units of two university hospitals.
  
  
  METHODS
  Three patients with purpura fulminans and multiple organ failure caused by Neisseria meningitidis.
  
  
  METHODS
  Intravenous administration of PC concentrate (100 IU/kg every 6 to 8 hrs).
  
  
  RESULTS
  The administration of PC resulted in normal or above normal levels of the plasma PC activity in all patients. The laboratory and clinical parameters reflecting the severity of coagulopathy improved during the treatment, as did peripheral ischemia and the clinical manifestations of multiple organ failure. No adverse events were noted. One patient died of cerebral edema.
  
  
  CONCLUSIONS
  The administration of PC had a beneficial effect on coagulopathy and peripheral gangrene formation associated with meningococcal disease and showed no adverse effects.
authors.affiliation: Department of Medicine, Turku University Central Hospital, Kiinamyllynkatu, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Rintala
authors.forename: O P
authors.initials: OP
authors.lastname: Seppälä
authors.forename: P
authors.initials: P
authors.lastname: Kotilainen
authors.forename: V
authors.initials: V
authors.lastname: Pettilä
authors.forename: V
authors.initials: V
authors.lastname: Rasi
mesh_terms: D000328:Adult; D003422:Critical Care; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000628:therapy*; D008297:Male; D008585:Meningitis, Meningococcal / Q000150:complications*; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000517:prevention & control; D011486:Protein C / Q000627:therapeutic use*
chemical_list: D011486:Protein C