title: Dihydroorotate dehydrogenase. Profile of a novel target for antiproliferative and immunosuppressive drugs.
authors.affiliation: Institute for Physiological Chemistry, School of Medicine, Philipps-University, Marburg, Germany. loeffler@mailer.uni-marburg.de
authors.forename: M
authors.initials: M
authors.lastname: Löffler
authors.forename: K
authors.initials: K
authors.lastname: Grein
authors.forename: W
authors.initials: W
authors.lastname: Knecht
authors.forename: A
authors.initials: A
authors.lastname: Klein
authors.forename: U
authors.initials: U
authors.lastname: Bergjohann
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000090722:Dihydroorotate Dehydrogenase; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007136:Immunoglobulins; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008954:Models, Biological; D010088:Oxidoreductases / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011743:Pyrimidines / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D000090722:Dihydroorotate Dehydrogenase; D004791:Enzyme Inhibitors; D007136:Immunoglobulins; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D011994:Recombinant Proteins; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors