title: Expression of interleukin-8 in human glomerulonephritis.
abstract: Interleukin-8 (IL-8) is a cytokine, which possesses both chemotactic and activating properties for neutrophils, lymphocytes and basophils. Various evidence has indicated IL-8 to be implicated in the pathophysiology of immune-mediated renal diseases. We thus examined the expression of IL-8 in renal diseases. We detected the expression of IL-8 both in mRNA and the protein levels in renal biopsy specimens obtained from patients with IgA nephropathy and lupus nephritis. A significant correlation was found between the expression of IL-8 mRNA and the number of neutrophils in the glomerulus. We also found a negative correlation between the expression of IL-8 mRNA and creatinine clearance. Our study thus suggested IL-8 to be involved in the pathophysiology of proliferative glomerulonephritis.
authors.affiliation: Department of Medicine III, Okayama University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sekikawa
authors.forename: N
authors.initials: N
authors.lastname: Kashihara
authors.forename: K
authors.initials: K
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
authors.forename: K
authors.initials: K
authors.lastname: Kanao
authors.forename: Y
authors.initials: Y
authors.lastname: Maeshima
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: H
authors.initials: H
authors.lastname: Makino
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis* / Q000235:genetics; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: D016209:Interleukin-8; D012333:RNA, Messenger