Venous thrombosis in a replanted finger with underlying factor V Leiden mutation.
Resistance to activated protein C (APC resistance) was described recently as a cause for thrombophilia. APC inactivates coagulation co-factors Va and VIIIa. A single base-pair mutation changing Arg506 to Gln at the APC cleavage site of the factor V gene leads to a factor V Leiden variant, which is the most frequent cause of APC resistance. Recently, its role in peripheral venous thrombosis during pregnancy was described. We here report a case with thrombosis of the venous anastomoses after finger replantation with resistance to activated protein C associated with factor V Leiden mutation.
Kenner
L
L
Department of Neurosurgery, University School of Medicine, Graz, Austria.
Schwarzl
F
F
Moshammer
H
H
Haas
F
F
Hoefler
G
G
Pierer
G
G
D000328:Adult; D005165:Factor V / Q000235:genetics*; D005383:Finger Injuries / Q000601:surgery*; D006801:Humans; D008297:Male; D009154:Mutation; D011183:Postoperative Complications; D011486:Protein C / Q000502:physiology; D012092:Replantation; D013924:Thrombophlebitis / Q000235:genetics*
D011486:Protein C; C095381:factor V Leiden; D005165:Factor V