Dihydroorotate dehydrogenase. Profile of a novel target for antiproliferative and immunosuppressive drugs.
Löffler
M
M
Institute for Physiological Chemistry, School of Medicine, Philipps-University, Marburg, Germany. loeffler@mailer.uni-marburg.de
Grein
K
K
Knecht
W
W
Klein
A
A
Bergjohann
U
U
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000090722:Dihydroorotate Dehydrogenase; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007136:Immunoglobulins; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008954:Models, Biological; D010088:Oxidoreductases / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011743:Pyrimidines / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
D000970:Antineoplastic Agents; D000090722:Dihydroorotate Dehydrogenase; D004791:Enzyme Inhibitors; D007136:Immunoglobulins; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D011994:Recombinant Proteins; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors