title: Preoperative GnRH analogue in hysteroscopic metroplasty.
abstract: OBJECTIVE
  To evaluate the effectiveness of Gonadotropin-Releasing Hormone analogue when administered preoperatively in hysteroscopic metroplasty.
  
  
  METHODS
  Prospective, comparative study.
  
  
  METHODS
  Sixty patients undergoing hysteroscopic metroplasty for septate uterus who were randomly allocated to pretreatment with two injections monthly of Gonadotropin-Releasing Hormone analogue or to no pretreatment. To assess the outcome of surgery three parameters were used: operative time (minutes), fluid adsorption (ml) and intraoperative bleeding.
  
  
  RESULTS
  No significant differences in the operating time (21.9 vs 22.9 min), fluid adsorption (395 ml, range 200-550 vs 515 ml, range 250-650), intraoperative bleeding and failure rate were found between pretreated patients and controls.
  
  
  CONCLUSIONS
  Preoperative treatment with Gonadotropin-Releasing Hormone analogue showed no advantage in hysteroscopic treatment of mullerian defects, but only an improvement, not statistically significant, in term of reduced operative time and fluid adsorption.
authors.affiliation: Department of Gynaecology and Obstetrics, School of Medicine, Second University of Naples, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Colacurci
authors.forename: P
authors.initials: P
authors.lastname: de Franciscis
authors.forename: A
authors.initials: A
authors.lastname: Mollo
authors.forename: D
authors.initials: D
authors.lastname: Mele
authors.forename: N
authors.initials: N
authors.lastname: Fortunato
authors.forename: R
authors.initials: R
authors.lastname: Zarcone
mesh_terms: D000328:Adult; D005260:Female; D017273:Goserelin / Q000627:therapeutic use*; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D015907:Hysteroscopy; D011446:Prospective Studies; D014599:Uterus / Q000002:abnormalities* / Q000187:drug effects / Q000601:surgery*
chemical_list: D017273:Goserelin