[A study of mechanism by which tumor growth was induced by partial hepatectomy].
In this study, 18 BUF rats with 7316 A liver cancer burden were divided into three groups. Groups A underwent simple laparotomy, group B had 70% hepatectomy, and group C with laparotomy plus TGF-beta . Splenic adhesive cells and serum of postoperative day 5 in both group A and B were added into mixed lymphocellular culture and CCL-64 cell culture, TGF-beta was also added into MLC and 7613 A liver cancer culture. It was found that in group B and C the growth rate of tumor cells was greatly accelerated (P < 0.01); whereas MLC and CCL-64 cell proliferation was inhibited by the serum and splenic adhesive cells from group B (P < 0.05). TGF-beta also significantly inhibited MLC through it had no effect on 7316 A liver cancer cells. The authors came to the conclusion that there was the activity of TGF-beta in the serum of the rats with partial hepatectomy which inhibits the proliferation of host immune cells.
Sun
J
J
Department of Surgery, Beijing Hospital.
Ito
T
T
Zhang
P
P
D000818:Animals; D002455:Cell Division; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D008114:Liver Neoplasms, Experimental / Q000473:pathology*; D007959:Lymphocyte Culture Test, Mixed; D009368:Neoplasm Transplantation; D051381:Rats; D011915:Rats, Inbred BUF; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000502:physiology*; D014407:Tumor Cells, Cultured
D016212:Transforming Growth Factor beta