title: Pathophysiology in endothelin-1 transgenic mice.
abstract: Transgenic mice expressing the human endothelin-1 (ET-1) were generated. These mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. Consequently, a progressive decrease in renal blood flow and/or glomerular filtration rate was observed, demonstrated by altered creatinine clearance and by magnetic resonance imaging. These genetically altered transgenic mice provide an interesting animal model in which to elucidate the role of ET-1 in the modulation of renal hemodynamics and glomerular and tubule functions.
authors.affiliation: University Clinic Charite, Humboldt University, Berlin, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Theuring
authors.forename: C
authors.initials: C
authors.lastname: Thöne-Reinecke
authors.forename: H
authors.initials: H
authors.lastname: Vogler
authors.forename: F
authors.initials: F
authors.lastname: Schmager
authors.forename: P
authors.initials: P
authors.lastname: Rohmeiss
authors.forename: T
authors.initials: T
authors.lastname: Slowinski
authors.forename: H H
authors.initials: HH
authors.lastname: Neumayer
authors.forename: B
authors.initials: B
authors.lastname: Hocher
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D019332:Endothelin-1 / Q000235:genetics* / Q000502:physiology*; D005919:Glomerular Filtration Rate; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D051379:Mice; D008822:Mice, Transgenic; D012079:Renal Circulation / Q000235:genetics* / Q000502:physiology*
chemical_list: D019332:Endothelin-1