Congenital mesoblastic nephroma and trisomy 11.
Cytogenetic analysis of a congenital mesoblastic nephroma (CMN) in a 1-month-old boy showed a 48,XY, +10, +11 karyotype. In this particular tumor type, chromosomal changes are found in almost all cases. Among the numerical changes, trisomy 11 stands out, whereas involvement of the long arm of chromosome 15 may be a nonrandomly occurring structural change.
Dal Cin
P
P
Center for Human Genetics, University of Leuven, Belgium.
Lipcsei
G
G
Hermand
G
G
Boniver
J
J
Van den Berghe
H
H
D002871:Chromosome Banding; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000151:congenital* / Q000235:genetics* / Q000473:pathology; D008297:Male; D018201:Nephroma, Mesoblastic / Q000151:congenital* / Q000235:genetics* / Q000473:pathology; D014314:Trisomy / Q000235:genetics*