[Protective effect of angiotensin coverting enzyme inhibitor on renal function in normotensive non-insulin dependent diabetes mellitus patients with early diabetic nephropathy and microalbuminuria].
Fourty six cases of non-insulin dependent diabetes mellitus (NIDDM) with normotension and microalbuminuria (< 30 mg/24 h) were divided into groups A and B, and observed for about 2 years. Only group A was treated with perindopril 2 mg a day. We found that 2 years later glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and filtration fraction (FF) in the two groups decreased markedly, but GFR and FF decreased more markedly in group B than in group A. Meanwhile, in group A urinary albumin excretion rate (UAER) and insulin sensitivity index (SI) decreased significantly and blood pressure was stable, but in group B UAER and blood pressure elevated significantly and SI was only slightly ameliorated (P > 0.05). The levels of serum triglycerides and cholesterol were not markedly different between the two groups during the 2 years. These results indicate that ACEI may play a role in protecting the renal function in diabetic nephropathy, reduce the risk factors of atherosclerosis and improve SI. It is beneficial to retard the development of diabetic nephropathy and to protect in renal function with small dose of ACEI.
Xia
H
H
Department of Endocrinology, First Hospital of Nanjing Medical University.
He
R
R
Chen
J
J
D000328:Adult; D000419:Albuminuria / Q000503:physiopathology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000517:prevention & control*; D005919:Glomerular Filtration Rate; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007668:Kidney / Q000503:physiopathology*; D008875:Middle Aged; D020913:Perindopril; D017595:Renal Plasma Flow
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; D020913:Perindopril