Clinical predictors of nephritis in systemic lupus erythematosus.
We identified clinical predictors of lupus nephritis presenting more than 6 months after the diagnosis of lupus in a cohort of 335 lupus patients. Almost 24% (80/335) of patients developed nephritis more than 6 months after the diagnosis of lupus. Using a Cox proportional hazards model, we found hypertension, thrombocytopaenia and leukopaenia to be associated with lupus nephritis presenting more than 6 months after diagnosis, with adjusted relative risks of 2.5 (95% CI 1.3 to 4.7), 4.3 (95% CI 1.7 to 10.8) and 3.2 (95% CI 1.7 to 6.2) respectively. In this cohort, hypertension, thrombocytopaenia and leukopaenia were associated with lupus nephritis presenting more than 6 months after the diagnosis of lupus.
Thumboo
J
J
Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
Fong
K Y
KY
Chia
H P
HP
Chng
H H
HH
Koh
E T
ET
Leong
K H
KH
Koh
W H
WH
Howe
H S
HS
Leong
K P
KP
Boey
M L
ML
Feng
P H
PH
D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology*; D015994:Incidence; D007970:Leukopenia / Q000150:complications / Q000453:epidemiology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis; D008181:Lupus Nephritis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011507:Proteinuria / Q000150:complications / Q000453:epidemiology*; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D012846:Singapore / Q000453:epidemiology; D013921:Thrombocytopenia / Q000150:complications / Q000453:epidemiology*