Treatment of T prolymphocytic leukemia with allogeneic bone marrow transplantation.
T prolymphocytic leukemia (T-PLL) is an unusual disease characterized by high white cell counts, older age at presentation, splenomegaly and a very aggressive clinical course. We describe a 47-year-old male with refractory T-PLL who was treated with high-dose chemoradiotherapy and allogeneic bone marrow transplantation (BMT) from an HLA-matched sibling. The transplant was complicated by both acute and chronic graft-versus-host disease (GVHD). The patient achieved complete remission and remains in remission 3 years after the transplant.
Collins
R H
RH
Bone Marrow Transplantation, Baylor University Medical Center/Texas Oncology, Dallas 75246, USA.
Piñeiro
L A
LA
Agura
E D
ED
Fay
J W
JW
D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease; D006650:Histocompatibility Testing; D006801:Humans; D015463:Leukemia, Prolymphocytic / Q000628:therapy*; D015458:Leukemia, T-Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged