Cardiac troponin T in patients with end-stage renal disease: absence of expression in truncal skeletal muscle.
In patients with end-stage renal disease (ESRD), the serum concentration of cardiac troponin T (cTnT) may be increased without cardiac ischemia. One reason for this unexplained increase could be the extracardiac expression of cTnT. However, truncal skeletal muscle biopsies of five patients with ESRD showed no evidence of the expression of either cTnT mRNA (reverse transcription-PCR) or protein (immunoblot, immunofluorescence). We also measured the serum concentration of cTnT in 97 patients with ESRD. The serum cTnT concentration determined in both first and second generation cTnT assays was significantly lower P <0.01 in patients with a low cardiac risk than in patients with positive indicators of coronary artery disease. The correlation between cTnT and indicators of coronary artery disease is consistent with the hypothesis that cTnT in the serum of patients with ESRD originates from the heart.
Haller
C
C
Department of Medicine III, University of Heidelberg, Germany.
Zehelein
J
J
Remppis
A
A
Müller-Bardorff
M
M
Katus
H A
HA
D000009:Abdominal Muscles / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000276:immunology; D001415:Back; D015415:Biomarkers / Q000032:analysis; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D006435:Renal Dialysis; D012307:Risk Factors; D014336:Troponin / Q000097:blood / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D020107:Troponin T
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D012333:RNA, Messenger; D014336:Troponin; D020107:Troponin T