title: Resistance of the human posterior lens capsule and zonules to disruption.
abstract: OBJECTIVE
  To determine the resistance of the human posterior lens capsule and zonules to disruption during cataract surgery.
  
  
  METHODS
  Wet lab at Walkergate Hospital, Newcastle upon Tyne, England.
  
  
  METHODS
  Human donor eyes were obtained after removal of a corneoscleral disc. Lens extraction was performed by an extracapsular technique leaving an intact capsular bag. The resistance of the zonules and posterior capsule to disruption by aspiration was measured in each eye, and the resistance of the zonules to damage from direct mechanical stretch was determined.
  
  
  RESULTS
  Posterior capsules tolerated a median suction pressure of 200 mm Hg (range 150 to 300 mm Hg) before disruption. Values for female eyes were slightly greater than for male; no significant correlation with age was shown. The zonular fibers tolerated a median suction pressure of 200 mm Hg (range 150 to 300 mm Hg). The median mechanical zonular stretch tolerance was 3.00 mm (range 2.75 to 4.00 mm). No significant correlation was found between zonular suction tolerance or stretch tolerance and sex or between suction tolerance and age, but a negative relationship was noted between maximum tolerated stretch and age.
  
  
  CONCLUSIONS
  Setting the maximum aspiration pressure during irrigation/aspiration to 150 mm Hg should help prevent capsular or zonular rupture. If more powerful aspiration is required, it should be used with great care so as not to engage the capsule.
authors.affiliation: Department of Ophthalmology, Newcastle General Hospital, Newcastle upon Tyne, England.
authors.forename: H R
authors.initials: HR
authors.lastname: Saber
authors.forename: T J
authors.initials: TJ
authors.lastname: Butler
authors.forename: D G
authors.initials: DG
authors.lastname: Cottrell
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction / Q000009:adverse effects; D004322:Drainage / Q000009:adverse effects; D004548:Elasticity; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D007903:Lens Capsule, Crystalline / Q000293:injuries* / Q000502:physiology; D008022:Ligaments / Q000293:injuries* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012421:Rupture; D007507:Therapeutic Irrigation