title: Effect of semi-annual applications of a chlorhexidine/fluoride varnish mixture on approximal caries incidence in schoolchildren. A three-year radiographic study.
abstract: Development and progression of approximal caries is still difficult to prevent and control even in societies with declining caries prevalence. In this study, a test group of 115 12-yr old children were treated semi-annually with a mixture (1:1) of a varnish containing 0.1% F (Fluor Protector) and 1.0% chlorhexidine (Cervitec). A reference group of 104 children received fluoride varnish treatment (Fluor Protector) semi-annually. Approximal caries was recorded from bitewing radiographs at baseline and after 3 yr. At baseline, total decayed and filled surfaces (DFS) including enamel caries were 1.79+/-2.36 in the reference group and 2.0+/-2.77 in the test group. After 3 yr, the mean approximal caries incidence including enamel caries was 3.01+/-3.74 and 3.78+/-4.32, respectively. The differences at baseline as well as after 3 yr were not statistically significant. The results showed that both groups had a comparatively low incidence of approximal caries during the experimental period, and suggest that a mixture of fluoride and antibacterial varnish had no additional preventive effect on approximal caries incidence compared with fluoride varnish treatments alone.
authors.affiliation: Department of Preventive Dentistry, Medical and Dental Health Center, Halmstad, Sweden. lars.g.petersson@lih.lthalland.se
authors.forename: L G
authors.initials: LG
authors.lastname: Petersson
authors.forename: K
authors.initials: K
authors.lastname: Magnusson
authors.forename: H
authors.initials: H
authors.lastname: Andersson
authors.forename: G
authors.initials: G
authors.lastname: Deierborg
authors.forename: S
authors.initials: S
authors.lastname: Twetman
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D002648:Child; D002710:Chlorhexidine / Q000008:administration & dosage*; D004245:DMF Index; D003731:Dental Caries / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000517:prevention & control*; D004338:Drug Combinations; D005460:Fluorides, Topical / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D011140:Polyurethanes / Q000008:administration & dosage*; D016300:Radiography, Bitewing; D012821:Silanes / Q000008:administration & dosage*; D013548:Sweden / Q000453:epidemiology; D013943:Thymol / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D005460:Fluorides, Topical; D011140:Polyurethanes; D012821:Silanes; C079161:chlorhexidine, thymol drug combination; D013943:Thymol; C022599:Fluor Protector; D002710:Chlorhexidine