Effects of CDP-choline administration on brain striatum platelet-activating factor in aging rats.
Cytidine 5'-diphosphocholine (CDP-choline) is a precursor in platelet-activating factor (PAF) biosynthesis and it is used in the treatment of diseases of the central nervous system. PAF levels in the striatum of aged (19 months) rats were 67% lower than those found in young (2 months) animals. Chronic treatment of aged rats with CDP-choline (500 mg/kg per day) reduced these PAF levels by more than 65% with respect to those of untreated aged rats after 8 days of treatment. PAF subsequently stabilized at these low levels as treatment continued. These results suggest that some effects of CDP-choline could be mediated by changes in brain PAF levels.
Giménez
R
R
Department of Biochemistry, Faculty of Pharmacy, University of Barcelona, Spain.
Aguilar
J
J
D000375:Aging / Q000378:metabolism; D000818:Animals; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D005260:Female; D017072:Neostriatum / Q000187:drug effects* / Q000378:metabolism; D018697:Nootropic Agents / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018697:Nootropic Agents; D010972:Platelet Activating Factor; D003566:Cytidine Diphosphate Choline