Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
A secreted CC chemokine homolog, encoded by the MC148 gene of molluscum contagiosum virus, potently interfered with the chemotaxis of human monocytes, lymphocytes, and neutrophils in response to a large number of CC and CXC chemokines with diverse receptor specificities. Evidence that the viral protein binds to human chemokine receptors was obtained by competition binding and calcium mobilization experiments. The broad spectrum chemokine antagonistic activity of MC148 can explain the prolonged absence of an inflammatory response in skin tumors that harbor replicating molluscum contagiosum virus.
Damon
I
I
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Murphy
P M
PM
Moss
B
B
D000595:Amino Acid Sequence; D001665:Binding Sites / Q000235:genetics; D019742:Chemokines, CC / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D008977:Molluscum contagiosum virus / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000819:agonists / Q000378:metabolism*; D016415:Sequence Alignment; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology
D019742:Chemokines, CC; D019707:Receptors, Chemokine; D014764:Viral Proteins