[Polymorphism in region V of mitochondrial DNA in indigenous populations of northern Asia].
The insertion and deletion polymorphisms of region V of mitochondrial DNA (mtDNA) were studied in three indigenous populations of northern Asia: Yakuts, Evens, and Koryaks. In Evens and Koryaks, polymorphism was not found. In Yakuts, a 9-bp deletion and a 4-bp insertion were revealed in mtDNA region V. Sequencing of mtDNA region V confirmed the presence of these mutations. The results obtained, together with data published earlier, indicate that the frequencies of both the deletion and the insertion in Yakuts are 1.21%. The association between the 9-bp deletion and the types of the mtDNA control region were studied. The data obtained indicated that this deletion belonged to the Asian deletion cluster.
Derenko
M V
MV
Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, Russia. ibpn@ibpn.magadan.su
Sheilds
G F
GF
D001208:Asia; D002872:Chromosome Deletion; D004251:DNA Transposable Elements; D004272:DNA, Mitochondrial / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D004251:DNA Transposable Elements; D004272:DNA, Mitochondrial
Polymorfizm regiona V mitokhondrial'noĭ DNK v populiatsiiakh korennykh zhiteleĭ Severnoĭ Azii.