title: -GG- specific cleavage via hole hopping through double-stranded DNA.
abstract: We examined the photoinduced DNA cleavage reaction of 32P-end labeled oligodeoxyribonucleotides which contain 5'-TGGGC-3', 5'-CGGGC-3', and 5'-TGGGT-3'. As for 5'-TGGGC-3' and 5'-TGGGT-3', the cleavage occurred most strongly at the middle of 5'-GGG-3' step, whereas the strongest cleavage occurred at the 5' side of 5'-GGG-3' in 5'-CGGGC-3' step. These results showed the 5' side base of 5'-GGG-3' step was very important for the sequence selectivity of 5'-GGG-3' cleavage.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: C
authors.initials: C
authors.lastname: Dohno
authors.forename: K
authors.initials: K
authors.lastname: Nakatani
authors.forename: I
authors.initials: I
authors.lastname: Saito
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D015226:Dinucleoside Phosphates; D009838:Oligodeoxyribonucleotides; C018309:guanylyl-(3'-5')-guanosine; D004247:DNA