Recovery of the immune system after exercise.
In the recovery phase after intense exercise is found suppressed blood concentration of lymphocytes, suppressed natural immunity of blood lymphocytes, decreased concentration of secretory IgA in mucosa, but increased blood concentration of neutrophils and increased levels in the blood of inflammatory cytokines. Thus, after intense long-term exercise, the immune system is characterized by concomitant inflammation and temporary suppression of the cellular immune system, the most pronounced findings being 2-4 h after the exercise. The underlying mechanisms are multifactorial and include neuroendocrinological and metabolic factors. High levels of cytokines, especially interleukin-6, are found in the recovery period after eccentric exercise, and it has been demonstrated that a close association exists between muscle damage and increased levels of interleukin-6.
Pedersen
B K
BK
The Copenhagen Muscle Research Centre, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark.
Rohde
T
T
Ostrowski
K
K
D006801:Humans; D007107:Immune System / Q000502:physiology*; D018482:Muscle, Skeletal / Q000276:immunology* / Q000378:metabolism*; D005082:Physical Exertion / Q000502:physiology*