title: Comparison of total parenteral nutrition and an oral, semielemental diet on body composition, physical function, and nutrition-related costs in patients with malabsorption due to acquired immunodeficiency syndrome.
abstract: BACKGROUND
  The nutrition management of patients with malabsorption syndromes due to acquired immunodeficiency syndrome (AIDS) is problematic. The aim of this study was to compare the effects of total parenteral nutrition (TPN) and an oral, semielemental diet (SED) on body weight, body composition, quality of life, survival, and medical costs in AIDS patients with malabsorption.
  
  
  METHODS
  This was a prospective, randomized, open-label study performed in outpatients. Twenty-three AIDS subjects (TPN group, 12; SED group, 11) with cryptosporidiosis, microsporidiosis, or malabsorption of unknown cause were randomized and followed. Subjects were prescribed equivalent amounts of formulas of similar composition for 3 months. Monthly estimations of caloric intake, body weight, body composition by bioimpedance analysis, and quality of life were recorded. Nutritional variables were analyzed by repeated-measures analysis of covariance, with the baseline measure as the covariate. Nutrition-related medical costs, survival, and indices of absorptive and immune function were compared,
  
  
  RESULTS
  Subjects had lost an average of 1.5 and 1.0 kg body wt/mo for TPN and SED during the 6 months before study entry (p < not significant). The TPN group consumed more total calories than the SED group (p < .05). Weight change during therapy was significantly different from pretreatment in both groups (p < .01 for TPN, p = .023 for SED). The TPN group gained more weight than the SED group (p = .057) and significantly more fat (p = .02), but the changes in body cell mass were similar in the two groups. Changes in weight and body composition correlated with caloric intake but not the mode of feeding. The SED group scored significantly better than the TPN group on a physical functioning subscale of quality of life (p < .01). Survival was similar in the two groups. TPN therapy cost almost four times more than SED. Peripheral blood CD4+ lymphocyte numbers were unaffected by either therapy. Intestinal function was not affected by either therapy.
  
  
  CONCLUSIONS
  An oral SED may reverse weight loss and wasting in AIDS patients with malabsorption.
authors.affiliation: Department of Medicine, St Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, NY 10025, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Kotler
authors.forename: L
authors.initials: L
authors.lastname: Fogleman
authors.forename: A R
authors.initials: AR
authors.lastname: Tierney
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001823:Body Composition; D001835:Body Weight; D017097:Electric Impedance; D002149:Energy Intake; D004750:Enteral Nutrition; D005526:Food, Formulated; D006801:Humans; D008286:Malabsorption Syndromes / Q000209:etiology / Q000628:therapy*; D010289:Parenteral Nutrition, Total; D011446:Prospective Studies; D011788:Quality of Life; D012709:Serum Albumin / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D012709:Serum Albumin