title: Metabolic changes in the brain during transient ischemia measured with microdialysis.
abstract: Forty-four patients with severe head injury were monitored for episodes of cerebral ischemia using jugular venous oxygen saturation (sjvO2), brain tissue pO2 (ti-pO2), and a microdialysis probe. The concentration of lactate and glucose were measured in the microdialysate. A total of 10 episodes of global ischemia were observed. The characteristic pattern of a simultaneous decrease in sjvO2 and brain ti-pO2 with an increase in the concentration of lactate occurred in all 10 patients. In addition, 3 episodes of regional ischemia were observed. Although brain ti-pO2 decreased to very low values and the concentration of lactate increased in the microdialysate, sjvO2 remained unchanged. Brain ti-pO2 adds another dimension to our cerebral monitoring by allowing the detection of regional cerebral ischemia.
authors.affiliation: Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Robertson
authors.forename: S P
authors.initials: SP
authors.lastname: Gopinath
authors.forename: M
authors.initials: M
authors.lastname: Uzura
authors.forename: A B
authors.initials: AB
authors.lastname: Valadka
authors.forename: J C
authors.initials: JC
authors.lastname: Goodman
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D007022:Hypotension / Q000150:complications / Q000378:metabolism; D002534:Hypoxia, Brain / Q000209:etiology / Q000378:metabolism* / Q000601:surgery; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000378:metabolism*; D007601:Jugular Veins; D017551:Microdialysis / Q000379:methods*; D010100:Oxygen / Q000097:blood; D014948:Wounds, Gunshot / Q000150:complications / Q000378:metabolism
chemical_list: D010100:Oxygen