Clinical and microbial spectrum of fungal keratitis in Singapore: a 5-year retrospective study.
BACKGROUND
The epidemiology of fungal keratitis varies geographically, but commonly occurs in warm, tropical climates. To determine the microbial and clinical characteristics of this disease in Singapore, we conducted a 5-year hospital-based retrospective study.


METHODS
A retrospective review of culture-positive fungal keratitis at the Singapore National Eye Center and Singapore General Hospital, from January 1991 to December 1995.


RESULTS
Twenty-nine consecutive cases of culture-positive fungal keratitis were seen over the study period. The mean age of the cases was 41 years and 23 were males. Amongst the varied occupations, 9 were construction workers. The most common cultured organisms were Fusarium sp. (52%) and Aspergillus flavus (17%). More than half had a history of ocular trauma prior to the development of keratitis, while a quarter had antecedent topical corticosteroid therapy. In contrast, only 2 patients were contact-lens wearers. Despite medical therapy, 10 patients eventually required therapeutic penetrating keratoplasties; of these, 6 were caused by Fusarium species.


CONCLUSIONS
Fusarium is the commonest cultured organism in fungal keratitis in Singapore and is associated with significant ocular morbidity.
Wong
T Y
TY
Singapore National Eye Center, Singapore.
Fong
K S
KS
Tan
D T
DT
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy; D001231:Aspergillus flavus / Q000302:isolation & purification*; D003315:Cornea / Q000382:microbiology* / Q000473:pathology; D015821:Eye Infections, Fungal / Q000453:epidemiology / Q000382:microbiology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D007634:Keratitis / Q000453:epidemiology / Q000382:microbiology* / Q000628:therapy; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012846:Singapore / Q000453:epidemiology; D014792:Visual Acuity
D000935:Antifungal Agents