The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates.
The effect of inhaled nitric oxide (iNO) on bleeding time and platelet aggregation was studied in nine newborn infants with resolving pulmonary hypertension. Infants treated with iNO at 40 ppm for 30 minutes had bleeding times that were nearly twofold longer than those obtained 24 hours after iNO was discontinued. iNO had no effect on in vitro platelet aggregation studies.
George
T N
TN
Department of Pediatrics, University of Iowa College of Medicine, Iowa City, USA.
Johnson
K J
KJ
Bates
J N
JN
Segar
J L
JL
D000280:Administration, Inhalation; D001760:Bleeding Time; D006801:Humans; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000494:pharmacology; D010547:Persistent Fetal Circulation Syndrome / Q000097:blood / Q000628:therapy*; D010974:Platelet Aggregation / Q000187:drug effects*
D009569:Nitric Oxide