title: A highly efficient synthesis of cyclaradine and its behaviour towards adenosine deaminase.
abstract: (+)-, (-)-, and (+/-)-Cyclaradines were efficiently synthesized from 2-aza-bicyclo[2.2.1]hept-5-en-3-one (ABH). (+)- and (+/-)-Cyclaradines were deaminated by adenosine deaminase whereas (-)-cyclaradine was not hydrolyzed under the same conditions.
authors.affiliation: Pharmaceutical Institute, Tohoku University, Sendai, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Katagiri
authors.forename: H
authors.initials: H
authors.lastname: Kokufuda
authors.forename: M
authors.initials: M
authors.lastname: Makino
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuhashi
authors.forename: C
authors.initials: C
authors.lastname: Kaneko
authors.forename: R
authors.initials: R
authors.lastname: Vince
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D015394:Molecular Structure; D013237:Stereoisomerism; D014740:Vidarabine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D007202:Indicators and Reagents; C014387:carbocyclic arabinosyladenine; D000243:Adenosine Deaminase; D014740:Vidarabine