[Alzheimer's disease: beta amyloid and lipid metabolism].
Amyloid deposits found in brains of Alzheimer's disease. Down's syndrome and normal aged individuals are composed mainly of aggregated amyloid beta (Ab), soluble form which is a normal protein. We previously reported that soluble Ab (sAb) in normal human plasma and cerebrospinal fluid is complexed to high density lipoprotein (HDL). Consequences of sAb association with the HDL and Ab involvement in the lipid turnover are discussed herein.
Kudinova
N V
NV
Russian Academy of Medical Sciences, School of Medicine, Russian Peoples, Friendship University, Moscow, Russia. koudin@imb.imb.ac.ru
Kudinov
A R
AR
Berezov
T T
TT
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000097:blood* / Q000235:genetics; D000818:Animals; D004314:Down Syndrome / Q000097:blood; D006801:Humans; D050356:Lipid Metabolism; D008969:Molecular Sequence Data
D016229:Amyloid beta-Peptides
Bolezn' Al'tsgeĭmera: amiloid beta i metabolizm lipidov.