Eosinophil cationic protein in serum of corticosteroid-sensitive and resistant bronchial asthma.
Theories for the inflammatory basis of bronchial asthma are presented. The phenomenon of corticosteroid resistance (CR) in bronchial asthma is also discussed. Resistance to corticosteroids, which occurs in about 5% patients with moderate and severe asthma, presents still an important diagnostic and therapeutical problem. In addition, present opinions on the role of eosinophils in the allergic bronchial inflammation were analyzed. The aim of this study was to monitor serum eosinophil cationic protein (ECP) level in asthma patients, sensitive and resistant to glucocorticosteroids (GCS), before and after prednisolone treatment. The resistance to steroids was determined, based on the oral prednisolone test according to Carmichael and vasoconstriction assay according to Stoughton and McKenzie. In the group of corticosteroid-sensitive (CS) asthmatic patients a statistically significant decrease of ECP level was observed, after 10 day administration of prednisolone in a daily dose of 20 mg, which was associated with a meaningful increase of FEV1 value. On the other hand, the level of ECP in the serum of patients resistant to corticosteroids, although also decreased under influence of prednisolone, was not correlated with the increase of FEV1 value.
Patkowski
J
J
Department of Internal Medicine and Allergology, University Medical School, Wrocław, Poland.
Wytrychowski
K
K
Medrala
W
W
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D001798:Blood Proteins / Q000032:analysis*; D004351:Drug Resistance; D047091:Eosinophil Granule Proteins; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012260:Ribonucleases; D014661:Vasoconstriction / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D011239:Prednisolone; D012260:Ribonucleases