title: The risk of missing angle neovascularization by omitting screening gonioscopy in acute central retinal vein occlusion.
abstract: OBJECTIVE
  The purpose of the study was to determine whether angle neovascularization can occur without pupillary margin neovascularization in central retinal vein occlusion (CRVO).
  
  
  METHODS
  The study design was a prospective study of the main question and a retrospective study of ancillary issues.
  
  
  METHODS
  The authors examined 105 eyes of 100 patients with CRVO having clinical evidence of ischemia between July 1, 1986, and March 18, 1996.
  
  
  METHODS
  The authors looked for iris and angle neovascularization with both undilated slit-lamp biomicroscopy and Zeiss four-mirror gonioscopy.
  
  
  METHODS
  The presence of anterior segment neovascularization was measured.
  
  
  RESULTS
  Of 34 eyes developing anterior segment neovascularization, 4 (12%) developed angle neovascularization without pupillary margin neovascularization over a mean follow-up of 2.2 +/- 2.4 standard deviation years.
  
  
  CONCLUSIONS
  Angle neovascularization can occur without pupillary margin involvement in CRVO, implying the necessity of screening gonioscopy and supporting the Central Vein Occlusion Study conclusion (based on a photographic technique not used clinically).
authors.affiliation: Charlotte Eye, Ear, Nose, and Throat Associates, North Carolina, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Browning
authors.forename: A Q
authors.initials: AQ
authors.lastname: Scott
authors.forename: C B
authors.initials: CB
authors.lastname: Peterson
authors.forename: J
authors.initials: J
authors.lastname: Warnock
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000869:Anterior Eye Segment / Q000098:blood supply*; D005260:Female; D005500:Follow-Up Studies; D015355:Glaucoma, Neovascular / Q000175:diagnosis / Q000209:etiology; D006068:Gonioscopy; D006801:Humans; D007498:Iris / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000209:etiology; D010781:Photography; D010818:Practice Patterns, Physicians'; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires