title: Impairment of dentato-thalamo-cortical pathway in autistic men: language activation data from positron emission tomography.
abstract: Recent evidence suggests disturbances of serotonin synthesis affecting the dentato-thalamo-cortical pathway in autistic boys. We studied possible effects of such disturbances on brain activations for language in autistic adults. Four autistic and five normal men were studied while listening to, repeating, and generating sentences, using [15(O)]-water positron emission tomography (PET). Activation in the right dentate nucleus and in the left frontal area 46 was reduced during verbal auditory and expressive language and enhanced during motor speech functions in the autism as compared to the control group. The thalamus showed group differences concordant with area 46 for expressive language. The results may indicate atypical functional specialization of the dentato-thalamo-cortical pathway and are compatible with a model of region-specific biochemical disturbances in the developing autistic brain.
authors.affiliation: Department of Pediatrics at Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit 48201-2196, USA. rmueller@pet.wayne.edu
authors.forename: R A
authors.initials: RA
authors.lastname: Müller
authors.forename: D C
authors.initials: DC
authors.lastname: Chugani
authors.forename: M E
authors.initials: ME
authors.lastname: Behen
authors.forename: R D
authors.initials: RD
authors.lastname: Rothermel
authors.forename: O
authors.initials: O
authors.lastname: Muzik
authors.forename: P K
authors.initials: PK
authors.lastname: Chakraborty
authors.forename: H T
authors.initials: HT
authors.lastname: Chugani
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D018891:Dentate Gyrus / Q000098:blood supply / Q000000981:diagnostic imaging*; D006801:Humans; D007361:Intelligence Tests; D007802:Language; D008297:Male; D009434:Neural Pathways / Q000098:blood supply / Q000000981:diagnostic imaging; D017397:Prefrontal Cortex / Q000098:blood supply / Q000000981:diagnostic imaging*; D013788:Thalamus / Q000098:blood supply / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed