Central action of 9-methyl-7-bromoeudistomin D (MBED), a derivative of eudistomin D isolated from Eudistoma olivaceum.
The behavioral responses of mice following intracerebroventricular (i.c.v.) injection of 9-methyl-7-bromoeudistomin D (MBED) were studied. Head-twitches were produced 20-90 min after the injection of 2, 20 and 200 nmol/mouse but such twitches were not significantly induced by caffeine (1000 nmol/mouse). The locomotor activity, as assessed by the Animex autometer, increased 0-120 min after the injection with doses of 2, 20 and 200 nmol/mouse, whereas a large dose of caffeine (500 nmol/mouse also increased the activity counts. Simultaneous injection of picrotoxin (3 mg/kg, s.c.) and MBED (50, 100 and 200 nmol/mouse) produced clonic and tonic extensive convulsions, but caffeine (1000 nmol/mouse) in combination with picrotoxin did not cause any type of convulsion.
Tadano
T
T
Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
Takahashi
N
N
Nakagawasai
O
O
Tan-no
K
K
Kaneko
S
S
Matsunaga
K
K
Ohizumi
Y
Y
Kisara
K
K
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
D002243:Carbolines; C060741:9-methyl-7-bromoeudistomin D