title: High-salt effects on the structure and damage of chromosomal DNA in Halobacterium salinarium, an extremely halophilic bacterium.
abstract: High concentration salt effects on the structure and radiation-induced damages of DNA were studied to elucidate the biochemical mechanism of the resistance of halophilic H. salinarium against DNA damaging agents. High concentration of KCl did not induce significant conformational changes in H. salinarium chromosomal DNA, but exhibited an extensive protective effect on the radiation-induced single-strand breaks of plasmid DNA.
authors.affiliation: Graduate Department of Gene Science, Faculty of Science, Hiroshima University, Higashi-Hiroshima, Japan.
authors.forename: H R
authors.initials: HR
authors.lastname: Shahmohammadi
authors.forename: H
authors.initials: H
authors.lastname: Terato
authors.forename: E
authors.initials: E
authors.lastname: Asgarani
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Fumamizu
authors.forename: Y
authors.initials: Y
authors.lastname: Ohyama
authors.forename: K
authors.initials: K
authors.lastname: Gekko
authors.forename: H
authors.initials: H
authors.lastname: Ide
mesh_terms: D002876:Chromosomes, Bacterial / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D004269:DNA, Bacterial / Q000737:chemistry / Q000187:drug effects / Q000235:genetics*; D005720:Gamma Rays; D019617:Halobacterium salinarum / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D009690:Nucleic Acid Conformation; D009994:Osmolar Concentration; D010957:Plasmids; D011189:Potassium Chloride / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D004269:DNA, Bacterial; D012965:Sodium Chloride; D011189:Potassium Chloride