Endothelin-1 in the heart during exercise.
In addition to its potent vasocontractile effects, endothelin-1 (ET-1) has potent positive inotropic and chronotropic effects on isolated heart muscles in vitro. However, it is not known whether the production of ET-1 in the heart is altered by exercise. In this study we investigated the production of ET-1 in the heart during exercise. Rats performed treadmill running of 45-min duration. Sedentary rats served as controls. Immediately after exercise, the heart was quickly removed. The peptide level of ET-1 in the heart was measured by a sandwich-enzyme immunoassay. The peptide level of ET-1 in the heart was significantly higher in the exercise group than in the control sedentary group. Therefore, we have demonstrated that production of ET-1 in the heart is increased by exercise. The present study suggests that myocardial ET-1 participates in the modulation of cardiac function during exercise.
Maeda
S
S
Department of Sports Medicine, University of Tsukuba, Ibaraki, Japan.
Miyauchi
T
T
Sakai
S
S
Kobayashi
T
T
Goto
K
K
Sugishita
Y
Y
Matsuda
M
M
D000818:Animals; D019332:Endothelin-1 / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008297:Male; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism*; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D019332:Endothelin-1