title: Long-term follow-up in hypertrophic obstructive cardiomyopathy after septal myectomy.
abstract: BACKGROUND
  Controversy exists about the choice of treatment for patients with hypertrophic obstructive cardiomyopathy. The purpose of this study was to evaluate clinical and echocardiographic long-term results in patients with hypertrophic obstructive cardiomyopathy after septal myectomy and to determine predictors of event-free survival in these patients.
  
  
  METHODS
  Between 1965 and 1995, 110 consecutive patients 2 to 66 years old (mean age, 37 +/- 15 years) with an invasively measured left ventricular outflow tract gradient of 86 +/- 39 mm Hg (81 +/- 42 mm Hg by Doppler echocardiography) underwent either septal myectomy only (n = 87) or myectomy combined with additional procedures (n = 23). Mean follow-up was 11.7 +/- 7.5 years. Predictors of late events were calculated using multivariate Cox regression analysis.
  
  
  RESULTS
  The perioperative mortality rate was 3.6% (n = 4). The cumulative survival rate at 5, 10, and 15 years was 93%, 80%, and 72%, respectively, and symptom-free survival, 77%, 50%, and 33%, respectively. Predictors of late death were New York Heart Association class III or IV (p < 0.05), congestive heart failure (p < 0.05) and additional procedures (p < 0.05). The left ventricular outflow tract gradient was nearly eliminated in all patients, the left atrial dimension decreased significantly during the early years, and left ventricular dilatation occurred late in 17 patients.
  
  
  CONCLUSIONS
  Septal myectomy is associated with a low perioperative mortality and a high late survival rate (72% at 15 years' follow-up). Septal myectomy is still an excellent modality in the treatment strategy for symptomatic patients with hypertrophic obstructive cardiomyopathy.
authors.affiliation: Department of Surgery, University Hospital, Zurich, Switzerland.
authors.forename: M H
authors.initials: MH
authors.lastname: Schönbeck
authors.forename: H P
authors.initials: HP
authors.lastname: Brunner-La Rocca
authors.forename: P R
authors.initials: PR
authors.lastname: Vogt
authors.forename: M L
authors.initials: ML
authors.lastname: Lachat
authors.forename: R
authors.initials: R
authors.lastname: Jenni
authors.forename: O M
authors.initials: OM
authors.lastname: Hess
authors.forename: M I
authors.initials: MI
authors.lastname: Turina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004108:Dilatation, Pathologic / Q000473:pathology; D018572:Disease-Free Survival; D015150:Echocardiography, Doppler; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006325:Heart Atria / Q000473:pathology; D006333:Heart Failure / Q000503:physiopathology; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications; D012086:Reoperation; D015996:Survival Rate; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery