B-cell lymphopoiesis in mouse and man.
Functional immunoglobulin gene rearrangement is a sine qua non for successful B cell development in mammalian bone marrow, but other factors are also important. Studies reported during the past year have contributed new insight into the surface receptor complexes and signaling outcomes that influence the fate of B cell precursors. Identification and characterization of secreted and membrane-associated stromal cell products, and their actions on B-cell precursors, was a parallel area of ongoing investigation.
LeBien
T W
TW
Department of Laboratory Medicine/Pathology, University of Minnesota Cancer Center, Minneapolis 55455, USA. lebie001@tc.umn.edu
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001853:Bone Marrow / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D011947:Receptors, Antigen, B-Cell