Multiple lower limb non-ossifying fibromas in siblings with neurofibromatosis.
Non-ossifying fibromas are common benign lesions of tubular long bones. There is recognized association of these bony lesions with neurofibromatosis type 1 although the presence of non-ossifying fibromas in familial members with the condition has not previously been reported. We report two siblings with neurofibromatosis and radiological evidence of multiple lower limb non-ossifying fibromas. Both patients presented with pain in the knees and a pathological fracture was observed in one case. Patients with multiple non-ossifying fibromas should be examined carefully for other evidence of neurofibromatosis.
Howlett
D C
DC
Department of Radiology, Guy's Hospital, London, UK.
Farrugia
M M
MM
Ferner
R E
RE
Rankin
S C
SC
D000293:Adolescent; D001848:Bone Diseases, Developmental / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications / Q000235:genetics*; D011859:Radiography; D013978:Tibial Fractures / Q000209:etiology