Serotonin: and what about its side effects?
Many of the antidepressants introduced within the last decade have different and distinctive effects on neurotransmitter receptors, which delineate them from the older compounds. Clinically, these synaptic effects can be linked to therapeutic and certain adverse effects. Knowledge about these effects helps in understanding the advantages of newer compounds relative to the older compounds, and differences among new compounds in terms of their side effect profiles and certain drug interactions. Thus, the in vitro findings presented should help clinicians choose the most appropriate antidepressant for each patient and, potentially, will help to prevent or minimize the occurrence of certain side effects and drug interactions.
Richelson
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Mayo Clinic Jacksonville, Florida 32224, USA.
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009638:Norepinephrine / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D009638:Norepinephrine; D017981:Receptors, Neurotransmitter; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors