title: Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production.
authors.affiliation: The DuPont Merck Pharmaceutical Company, Experimental Station, Wilmington, Delaware 19880-0500, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Xue
authors.forename: X
authors.initials: X
authors.lastname: He
authors.forename: J
authors.initials: J
authors.lastname: Roderick
authors.forename: W F
authors.initials: WF
authors.lastname: DeGrado
authors.forename: R J
authors.initials: RJ
authors.lastname: Cherney
authors.forename: K D
authors.initials: KD
authors.lastname: Hardman
authors.forename: D J
authors.initials: DJ
authors.lastname: Nelson
authors.forename: R A
authors.initials: RA
authors.lastname: Copeland
authors.forename: B D
authors.initials: BD
authors.lastname: Jaffee
authors.forename: C P
authors.initials: CP
authors.lastname: Decicco
mesh_terms: D018360:Crystallography, X-Ray; D006801:Humans; D006877:Hydroxamic Acids / Q000097:blood / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D007769:Lactams / Q000097:blood / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000097:blood / Q000494:pharmacology; D008213:Lymphocyte Activation; D020781:Matrix Metalloproteinase 1; D020780:Matrix Metalloproteinase 9; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000097:blood; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D006877:Hydroxamic Acids; D007769:Lactams; D008070:Lipopolysaccharides; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; C112417:SC 903; C112416:SE 205; D014409:Tumor Necrosis Factor-alpha; D008666:Metalloendopeptidases; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1