title: Giant cell collagenoma: a benign dermal tumor with distinctive multinucleate cells.
abstract: We present five cases of a hitherto unreported cutaneous neoplasm. The tumors appeared as solitary slow-growing flesh-colored nodules arising in young and middle-aged adults. They were located on the trunk, the upper extremities, and the face, and did not recur after complete excision. Clinically, they were diagnosed as dermal nevus, Spitz's nevus, fibroma, or neurofibroma. Histology revealed polypoid flat-dome-shaped lesions with a sharply demarcated matrix consisting of coarse hyalinized collagen bundles arranged in a prominent storiform pattern and separated by mucin-containing clefts. Despite a low overall cellularity, the tumors contained numerous, occasionally bizarre-shaped, multinucleate giant cells with crowded vesicular nuclei and a pale staining foamy cytoplasm, as well as plump fibroblastlike cells with analogous nuclear morphology. Atypical nuclei or mitotic figures were not observed. The cells were strongly positive for vimentin but negative for cytokeratin, smooth muscle actin, desmin, S-100 protein, CD34, factor XIIIa, and the macrophage markers KP1, Mac 387, and Ki-M1p, suggesting a fibroblastic origin. Based on the overall architecture, we conclude that these tumors probably represent a distinctive variant of solitary circumscribed storiform collagenoma (sclerotic fibroma) and propose the designation of giant cell collagenoma.
authors.affiliation: Department of Pathology and Lymph Node Registry at the German Association of Pathologists, University of Kiel, Buchholz, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Rudolph
authors.forename: C
authors.initials: C
authors.lastname: Schubert
authors.forename: D
authors.initials: D
authors.lastname: Harms
authors.forename: R
authors.initials: R
authors.lastname: Parwaresch
mesh_terms: D000328:Adult; D003095:Collagen Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007642:Keratosis / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism
chemical_list: D014746:Vimentin