title: Amplification and expression of the HMGIC gene in a benign endometrial polyp.
abstract: In a totally benign endometrial polyp, double minute chromosomes were shown to contain an amplified and apparently nonrearranged HMGIC gene, expressed in the tumor cells, suggesting amplification of HMGIC through double minute chromosome formation as another hitherto unreported mechanism associated with the development of some mesenchymal tumors.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: S
authors.initials: S
authors.lastname: Wanschura
authors.forename: B
authors.initials: B
authors.lastname: Kazmierczak
authors.forename: G
authors.initials: G
authors.lastname: Tallini
authors.forename: A
authors.initials: A
authors.lastname: Dei Tos
authors.forename: J
authors.initials: J
authors.lastname: Bullerdiek
authors.forename: I
authors.initials: I
authors.lastname: Van den Berghe
authors.forename: P
authors.initials: P
authors.lastname: Moerman
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D002869:Chromosome Aberrations / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D025743:HMGA2 Protein; D006609:High Mobility Group Proteins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics; D011127:Polyps / Q000235:genetics* / Q000473:pathology
chemical_list: D025743:HMGA2 Protein; D006609:High Mobility Group Proteins; D009363:Neoplasm Proteins