title: Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat.
abstract: The aim of the present work was to assess the capacity of Spirulina maxima to prevent fatty liver development induced in rats by an intraperitoneal single dose (1 ml/kg) of carbon tetrachloride. Liver and serum lipids were quantified two or four days after treatment with this agent. Liver lipid concentration did not differ in rats fed on a purified diet with or without Spirulina. However, after carbon tetrachloride treatment, liver triacylglycerols were significantly lower in rats fed on a diet with Spirulina 5% than in rats without Spirulina in their diet (P < 0.05). Furthermore, the increased liver cholesterol values, induced by carbon tetrachloride treatment, were not observed in rats that received Spirulina. These results support the potential hepatoprotective role of Spirulina.
authors.affiliation: Departamento de Bioquímica, UNAM, México, D.F., Mexico.
authors.forename: P V
authors.initials: PV
authors.lastname: Torres-Durán
authors.forename: R
authors.initials: R
authors.lastname: Miranda-Zamora
authors.forename: M C
authors.initials: MC
authors.lastname: Paredes-Carbajal
authors.forename: D
authors.initials: D
authors.lastname: Mascher
authors.forename: J C
authors.initials: JC
authors.lastname: Díaz-Zagoya
authors.forename: M A
authors.initials: MA
authors.lastname: Juárez-Oropeza
mesh_terms: D000208:Acute Disease; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D000458:Cyanobacteria; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000139:chemically induced / Q000517:prevention & control*; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008055:Lipids; D002251:Carbon Tetrachloride