title: Comparative in vitro activities of four new fluoroquinolones against Streptococcus pneumoniae determined by Etest.
abstract: Clinafloxacin, levofloxacin, sparfloxacin and trovafloxacin were tested by Etest against 188 Streptococcus pneumoniae isolates. Clinafloxacin and trovafloxacin were 2-4-fold more potent than sparfloxacin and 8-fold more than levofloxacin. Two isolates, both serotype 6, with high-level quinolone resistance (> or = 8 micrograms/ml) were detected. The Etest is a practical means for determining S. pneumoniae susceptibilities to new fluoroquinolones.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham 35233-7331, USA. waites@path.uab.edu
authors.forename: K
authors.initials: K
authors.lastname: Waites
authors.forename: E
authors.initials: E
authors.lastname: Brookings
authors.forename: S
authors.initials: S
authors.lastname: Nix
authors.forename: A
authors.initials: A
authors.lastname: Robinson
authors.forename: B
authors.initials: B
authors.lastname: Gray
authors.forename: E
authors.initials: E
authors.lastname: Swiatlo
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests / Q000379:methods; D009287:Naphthyridines / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D015363:Quinolones; D064704:Levofloxacin; C057477:clinafloxacin; C080163:trovafloxacin; D015242:Ofloxacin; C061363:sparfloxacin