[New bioactive compounds of the adrenal medullary layer].
The review of new data of the studies of the cerebral layers of eight cardioactive peptide and clieopeptide combinations. Research of the physical-chemical and biochemical properties confirm nonidentity of these combinations to the known bioactive peptides of adrenals. The proteins connecting the factors under exploration have also been discovered, suggesting existence of cardioactive protein-peptide complexes in this region. Based on comparison of the studied chemical and biological properties of these combinations with the combinations of hypothalamic cardioactive neurohormones, in particular, with the neurohormone "C", a conclusion was made that combinations of the two regions are structurally and functionally related. The obtained data can be used in practical medicine for prophylactics and treatment of several cardiovascular diseases.
Srapionian
R M
RM
Institute of Biochemistry named after Acad. G.H. Bunianian, NAN of Armenia, Yerevan.
Paronian
Z Kh
ZKh
Saakian
S A
SA
D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D002317:Cardiovascular Agents / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D006020:Glycopeptides / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology; D010455:Peptides / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology; D011485:Protein Binding
D002317:Cardiovascular Agents; D006020:Glycopeptides; D010455:Peptides
Novye bioaktivnye soedineniia mozgovogo sloia nadpochechnikov.