title: The significance of involved tumour bed biopsy following wide local excision of breast cancer.
abstract: OBJECTIVE
  Following wide local excision of breast cancer approximately 25% of patients have residual disease in the tumour bed. The aim of this study was to determine whether positive bed biopsy correlated with either local recurrence or overall survival.
  
  
  METHODS
  Following wide excision bed biopsies were taken at four separate sites from the tumour bed. Histopathological assessment of the bed biopsies was made and compared to features within the primary tumour. Patients were followed-up over a median period of 6.17 years and local recurrence and survival data documented.
  
  
  RESULTS
  Two hundred and sixty-eight patients were included in the study and 63 had positive bed biopsies. In all, 85 patients had a recurrence of breast cancer and 69 died. Kaplan-Meier plots showed no evidence of a difference in survival between bed biopsy positive and negative patients. Bed biopsy positive patients were at greater risk of local recurrence.
  
  
  CONCLUSIONS
  These findings suggest that positive bed biopsy is associated with an increase in local recurrence rates but has no effect on overall survival following wide excision of breast cancer.
authors.affiliation: Department of Surgery, University College London, UK.
authors.forename: I
authors.initials: I
authors.lastname: Taylor
authors.forename: M A
authors.initials: MA
authors.lastname: Mullee
authors.forename: R
authors.initials: R
authors.lastname: Carpenter
authors.forename: G
authors.initials: G
authors.lastname: Royle
authors.forename: C J
authors.initials: CJ
authors.lastname: McKay
authors.forename: M
authors.initials: M
authors.lastname: Cross
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012306:Risk; D016019:Survival Analysis