title: Effects of cholecystectomy on gastric emptying and myoelectrical activity in man.
abstract: To investigate the effects of cholecystectomy on gastric motor function, 13 patients with symptomatic gallstones were studied before and 8-12 months after surgery. Twelve healthy subjects entered the study as control group. The cutaneous electrogastrography and ultrasound examination of gastric emptying were simultaneously performed at pre- and post-prandial states. The dominant gastric frequency and its coefficient of variation were not affected by surgery. After cholecystectomy, an increase in normal 3 cpm wave percentage and a decrease in power ratio were found (P < 0.05 and P < 0.01, respectively). Gastric emptying recorded after cholecystectomy was faster than before surgery (306.9 +/- 15.9 min vs 336.9 +/- 11.8 min, respectively; P < 0.05). Such changes were associated with the relief of symptoms, and the comparison between patients and controls showed a normalization of the gastric electrical activity and gastric emptying after surgery. In conclusion, in symptomatic patients, gallstones are associated with motor dysfunctions, and cholecystectomy seems to induce a normalization of gastrointestinal motility.
authors.affiliation: Laboratory of Experimental Pathophysiology, Scientific Institute of Gastroenterology, Castellana Grotte, Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Riezzo
authors.forename: M
authors.initials: M
authors.lastname: Chiloiro
authors.forename: F
authors.initials: F
authors.lastname: Pezzolla
authors.forename: D
authors.initials: D
authors.lastname: Lorusso
mesh_terms: D000328:Adult; D000368:Aged; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D004415:Dyspepsia / Q000209:etiology / Q000503:physiopathology; D004568:Electrodiagnosis; D005260:Female; D005414:Flatulence / Q000209:etiology / Q000503:physiopathology; D005500:Follow-Up Studies; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D011184:Postoperative Period