title: [Effect of diltiazem on jugular bulb oxygen saturation (SjO2)].
abstract: We investigated the effect of diltiazem on jugular bulb oxygen saturation (SjO2) in patients undergoing superficial temporal artery-middle cerebral artery anastomosis. In the presence of stable vital signs, diltiazem was administered by continuous infusion (2 micrograms.kg-1.min-1). There was no significant change in blood pressure, heart rate, SjO2 in response to diltiazem administration. The arterial plasma concentration of diltiazem reached 75 +/- 14.2 ng.ml-1 after 180 min. The difference of areas under the curve between the arterial and jugular venous diltiazem concentrations from start of infusion to the end was significant. We conclude that this dose of diltiazem produced effective concentration and uptake in the brain tissue, but produced no significant effect on jugular bulb oxygen saturation (SjO2).
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Hiroshima University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: I
authors.initials: I
authors.lastname: Nakagawa
authors.forename: M
authors.initials: M
authors.lastname: Kubota
authors.forename: H
authors.initials: H
authors.lastname: Niinai
authors.forename: T
authors.initials: T
authors.lastname: Kamiya
authors.forename: H
authors.initials: H
authors.lastname: Unetani
authors.forename: A
authors.initials: A
authors.lastname: Sakai
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D001157:Arterial Occlusive Diseases / Q000601:surgery; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D002343:Carotid Artery, Internal; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004110:Diltiazem / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D007601:Jugular Veins; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D004110:Diltiazem; D010100:Oxygen