Temporal filter of the motion sensor in glaucoma.
Glaucoma reportedly affects motion perception. As an initial step in characterizing glaucoma-induced changes in the motion system, we determined the range of temporal frequencies that the motion system could process. A noise-masking paradigm was used to measure contrast energy thresholds of 26 glaucoma patients at various stages of the disease and 16 age-similar subjects with normal vision. Using a sinusoidal stimulus, thresholds were measured for the discrimination of motion direction and for the stimulus embedded within a pattern of dynamic spatial noise. The noise was filtered to contain only low spatial frequencies, and the temporal-frequency spectrum of the noise was manipulated across conditions to derive the temporal filter shape of the most efficient motion sensor. The results show that the range of temporal frequencies processed by the motion system is diminished in the glaucoma group. The filters of the glaucoma subjects have reduced bandwidths compared with the normal-vision group. In addition, the upper cut-off frequency of the filters of the glaucoma subjects is correlated with stage of disease as indexed by the mean deviation of the Humphrey Visual Field Analyzer program 24-2, as well as the cup-to-disk ratio.
Turano
K A
KA
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. kathy@lions.med.jhu.edu
Huang
A S
AS
Quigley
H A
HA
D000328:Adult; D000368:Aged; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D008916:Miotics / Q000494:pharmacology; D009039:Motion Perception / Q000187:drug effects / Q000502:physiology*; D010862:Pilocarpine / Q000494:pharmacology; D012044:Regression Analysis; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology
D008916:Miotics; D010862:Pilocarpine