title: Synthetic analogues of netropsin and distamycin. IV. Synthesis of a new carbocyclic analogue of distamycin with alkylating side groups.
abstract: A carbocyclic analogue of distamycin was obtained, in which the N-methylpyrrole rings were substituted by disubstituted benzene rings. Additionally, N-chloro- or N-bromoacetyl groups, displaying alkylating properties, were introduced. The synthesis, starting from 3,5-dinitrobenzoyl chloride, consisted of five stages.
authors.affiliation: Department of Organic Chemistry, Institute of Chemistry, Medical Academy of Białystok.
authors.forename: A
authors.initials: A
authors.lastname: Markowska
authors.forename: D
authors.initials: D
authors.lastname: Bartulewicz
authors.forename: A
authors.initials: A
authors.lastname: Pućkowska
authors.forename: A
authors.initials: A
authors.lastname: Rózański
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry; D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D001554:Benzene / Q000737:chemistry; D004214:Distamycins / Q000138:chemical synthesis*; D009429:Netropsin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009579:Nitrobenzoates / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry
chemical_list: D000477:Alkylating Agents; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D004214:Distamycins; D009579:Nitrobenzoates; D011758:Pyrroles; C112321:chloroacetyldistamycin; C013964:3,5-dinitrobenzoyl chloride; D009429:Netropsin; C030000:stallimycin; C048820:M-bromoacetyldistamycin; D001554:Benzene; C096654:N-methylpyrrole