title: Chemopreventive activity of oltipraz.
abstract: The antischistosomal agent oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] has been shown to inhibit chemically induced carcinogenesis in a variety of animal models. Of greatest interest is its unique ability to protect several target organs from structurally diverse carcinogens. Molecular and biochemical studies suggest that oltipraz affords cellular protection by inducing the expression of a battery of Phase II detoxification enzymes. Induction of glutathione S-transferase, gamma-glutamylcysteine synthetase and DT-diaphorase has been observed in human tissues following the administration of a single oral dosage of oltipraz. Preclinical and clinical data continue to support the development of oltipraz as a chemopreventive agent for clinical usage.
authors.affiliation: Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Clapper
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001682:Biological Availability; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D004790:Enzyme Induction / Q000187:drug effects; D005721:Glutamate-Cysteine Ligase / Q000096:biosynthesis; D005982:Glutathione Transferase / Q000096:biosynthesis; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000096:biosynthesis; D011719:Pyrazines / Q000494:pharmacology* / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D012556:Schistosomicides / Q000494:pharmacology* / Q000627:therapeutic use; D013871:Thiones; D013876:Thiophenes; D014018:Tissue Distribution
chemical_list: D016588:Anticarcinogenic Agents; D011719:Pyrazines; D018894:Reverse Transcriptase Inhibitors; D012556:Schistosomicides; D013871:Thiones; D013876:Thiophenes; C026209:oltipraz; D016660:NAD(P)H Dehydrogenase (Quinone); D005982:Glutathione Transferase; D005721:Glutamate-Cysteine Ligase