Early diagnosis of myocardial infarction with MB CK isoforms.
Over 5 million patients with chest pain present annually to the ER in the US but only 10% will have infarction with < 50% identified by ECG. Early diagnosis of infarction in the ER to triage provides more appropriate and early therapy, less unnecessary use of CCU, and is more cost effective. A rapid automated MB CK isoform assay (25 min) was evaluated in a prospective study of 1110 patients presenting to the ER with chest pain. This assay was shown to have a sensitivity of 96% and specificity of 93% to diagnose infarction within 6 h of onset of chest pain. In 92% the diagnosis was confirmed within 1 h of arrival at the ER. Similar sensitivity and specificity for total MB CK, troponin T, and troponin I required 16 h from onset of pain. Thus, MB CK isoforms provide a rapid diagnosis early after onset of infarction and have the requisite sensitivity and specificity for triaging patients in the ER.
Roberts
R
R
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
D015415:Biomarkers; D003402:Creatine Kinase / Q000097:blood; D004311:Double-Blind Method; D004586:Electrophoresis; D005069:Evaluation Studies as Topic; D006801:Humans; D007527:Isoenzymes; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014218:Triage; D014336:Troponin / Q000378:metabolism; D019210:Troponin I / Q000378:metabolism; D020107:Troponin T
D015415:Biomarkers; D007527:Isoenzymes; D009211:Myoglobin; D014336:Troponin; D019210:Troponin I; D020107:Troponin T; D003402:Creatine Kinase