[Do cardioselective beta-antagonists block the cardiac beta-receptor function also in the long run?].
As the human cardiomyocyte expresses both beta 1 and beta 2 adrenoceptors it is to be expected that the inhibition of one species of receptors can be counteracted by the other. This hypothesis was tested in 40 middle-aged men scheduled for coronary artery bypass surgery. Half the patients had been treated with cardioselective beta 1 antagonists for more than three months while the 20 control patients had never been beta-blocked. The haemodynamic status after induction of a standardized fentanyl/midazolam anaesthesia and the sensitivity of the cardiovascular beta-adrenoceptors to isoprenaline titration were similar in both groups. In conclusion, patients chronically treated with cardioselective beta 1-blockers compensate for the perturbation to such a degree that their cardiovascular function is indistinguishable from patients who have never received beta-blockers.
Yndgaard
S
S
Anaestesiologisk afdeling, Amtssygehuset i Gentofte.
Lippert
F K
FK
Berthelsen
P G
PG
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D001262:Atenolol / Q000008:administration & dosage; D017298:Bisoprolol / Q000008:administration & dosage; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D002316:Cardiotonic Agents; D011943:Receptors, Adrenergic, beta; D001262:Atenolol; D008790:Metoprolol; D007545:Isoproterenol; D017298:Bisoprolol
Blokerer kardioselektive beta-antagonister hjertets beta-receptorfunktion også på laengere sigt?