title: Cystothiazoles A and B, new bithiazole-type antibiotics from the myxobacterium Cystobacter fuscus.
abstract: New bithiazole-type antibiotics, cystothiazoles A (C20H26N2O4S2) and B (C20H26N2O5S2), have been isolated from a culture broth of the myxobacterium, Cystobacter fuscus. The gross structures of these compounds were elucidated by spectroscopic analysis, and their absolute stereochemistry was determined by chemical degradation of cystothiazole A. Cystothiazole A inhibits fungi and human tumor cells, whereas it is inactive against bacteria. The antifungal activity appears to result from the inhibition of submitochondrial NADH oxidation. Although these compounds are structurally related to the known antibiotic myxothiazol, cystothiazole A was more active against fungi and less cytotoxic than myxothiazol.
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ojika
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Tsukamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Sakagami
authors.forename: R
authors.initials: R
authors.lastname: Fudou
authors.forename: T
authors.initials: T
authors.lastname: Yoshimura
authors.forename: S
authors.initials: S
authors.lastname: Yamanaka
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008968:Molecular Conformation; D009231:Myxococcales / Q000378:metabolism*; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013844:Thiazoles; C112182:cystothiazole A; C112183:cystothiazole B