title: [18-year-old patient with hypercalcemia, hypophosphatemia, nephrocalcinosis and normal iPTH values. Primary hyperparathyroidism].
abstract: We report an 18-year old woman with surgically proven primary hyperparathyroidism (pHPT) and normal intact parathyroid hormone (iPTH) serum levels. The reason for this rare biochemical presentation are possible biologically active amino-terminal parathyroid hormone polypeptide fragments not detected by the widely used two-site immunoradiometric parathyroid hormone assay (PTH IRMA). Diagnosis and therapy of primary hyperparathyroidism therefore should not exclusively rest on the finding of hypercalcemia coupled with an elevated iPTH level.
authors.affiliation: Hospital of the University of Pennsylvania, Philadelphia 19104-6070, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Baumgart
authors.forename: M
authors.initials: M
authors.lastname: Ventz
authors.forename: W
authors.initials: W
authors.lastname: Wermke
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000473:pathology; D017674:Hypophosphatemia / Q000209:etiology* / Q000473:pathology; D015592:Immunoradiometric Assay; D007669:Kidney Calculi / Q000209:etiology* / Q000473:pathology; D010280:Parathyroid Glands / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood*; D010282:Parathyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011237:Predictive Value of Tests
chemical_list: D010281:Parathyroid Hormone
vernacular_title: 18jährige Patientin mit Hyperkalziämie, Hypophosphatämie, Nephrokalzinose und im Normbereich gelegenen iPTH. Primärer Hyperparathyreoidismus.