The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils.
(S)-4-Carboxy-3-hydroxy-phenylglycine [(S)-4C3HPG] is a potent competitive antagonist at the metabotropic glutamate receptor 1 subtype (mGlu1 receptor) and an agonist at mGlu2/3 receptor. We evaluated histologically the effect of this compound on transient global ischaemia in gerbils and observed pronounced neuroprotection in the CA1 layer of the hippocampus. When (S)-4C3HPG (1 microM) was administered intra-cerebroventricularly (i.c.v.) 20 min before clamping both common carotid arteries neuronal density was comparable with that in sham-operated animals. A single injection (1 microM) 65 min after ischaemia also significantly reduced neuronal damage. The results suggest that metabotropic glutamate receptors play a role in the deleterious cascade which leads to neuronal damage of pyramidal cells in the CA1 layer of the hippocampus after transient global ischaemia.
Henrich-Noack
P
P
Department of Neurophysiology, Federal Institute for Neurobiology, Magdeburg, Germany.
Hatton
C D
CD
Reymann
K G
KG
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005849:Gerbillinae; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects*; D018709:Statistics, Nonparametric
D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D018094:Receptors, Metabotropic Glutamate; C078245:4-carboxy-3-hydroxyphenylglycine; D005998:Glycine