title: An indolent penile herpetic ulcer in a patient with previously undiagnosed human immunodeficiency virus infection.
abstract: We report a case of an atypical penile herpetic ulcer in a man with previously undiagnosed human immunodeficiency virus (HIV) infection. Swabs of the lesion were negative for herpes simplex virus (HSV) by culture and electron microscopy. However, histopathology of biopsy material showed characteristic herpetic multinucleate giant cells. Immunochemistry using polyclonal antibodies was positive for HSV1 and HSV2. The lesion completely resolved after treatment with aciclovir and the patient subsequently tested positively for HIV antibodies.
authors.affiliation: Department of Genito-Urinary Medicine, Newcastle General Hospital, Newcastle Upon Tyne, U.K.
authors.forename: S C
authors.initials: SC
authors.lastname: Tayal
authors.forename: R S
authors.initials: RS
authors.lastname: Pattman
authors.forename: J
authors.initials: J
authors.lastname: Mclelland
authors.forename: L
authors.initials: L
authors.lastname: Sviland
authors.forename: M H
authors.initials: MH
authors.lastname: Snow
mesh_terms: D000328:Adult; D002908:Chronic Disease; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis; D006558:Herpes Genitalis / Q000150:complications* / Q000175:diagnosis; D018259:Herpesvirus 1, Human; D018258:Herpesvirus 2, Human; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010409:Penile Diseases / Q000821:virology*; D014456:Ulcer / Q000821:virology*