title: A model to investigate postoperative ileus with strain gauge transducers in awake rats.
abstract: BACKGROUND
  Postoperative ileus influences patients well-being, hospital stay, and health cost, and postoperative inhibition of colonic motility is a major contributor to postoperative ileus. Experimental models for investigating postoperative ileus are needed. In particular, recording of postoperative colonic motility in awake rats has not been described yet.
  
  
  METHODS
  Gastric, small intestinal, and colonic motility were recorded with strain gauge transducers in awake rats, and the effects of anesthesia and abdominal surgery on gastrointestinal motility were investigated.
  
  
  RESULTS
  Ether anesthesia increased gastric motility and inhibited small intestinal motility, while enflurane anesthesia had only minor effects on gastrointestinal motility. Abdominal surgery inhibited gastric, small intestinal, and colonic motility, and a detailed analysis of gastrointestinal motility in our postoperative ileus model is given.
  
  
  CONCLUSIONS
  We established a model to record gastric, small intestinal, and colonic motility in awake rats postoperatively. We could demonstrate that enflurane anesthesia had little effect on gastrointestinal motility, while laparotomy and short manipulation of the cecum produced a prolonged inhibition of gastrointestinal motility. Our model could be used to investigate postoperative ileus, particularly of the colon, in awake rats.
authors.affiliation: University Hospital, Department of General and Transplantation Surgery, Tübingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Huge
authors.forename: M E
authors.initials: ME
authors.lastname: Kreis
authors.forename: E C
authors.initials: EC
authors.lastname: Jehle
authors.forename: H J
authors.initials: HJ
authors.lastname: Ehrlein
authors.forename: M
authors.initials: M
authors.lastname: Starlinger
authors.forename: H D
authors.initials: HD
authors.lastname: Becker
authors.forename: T T
authors.initials: TT
authors.lastname: Zittel
mesh_terms: D000005:Abdomen / Q000601:surgery; D018685:Anesthetics, Inhalation; D000818:Animals; D003106:Colon / Q000503:physiopathology; D004195:Disease Models, Animal; D004737:Enflurane / Q000008:administration & dosage; D004986:Ether / Q000008:administration & dosage; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D007415:Intestinal Obstruction / Q000503:physiopathology* / Q000601:surgery; D007421:Intestine, Small / Q000503:physiopathology; D007813:Laparotomy / Q000009:adverse effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000503:physiopathology; D014160:Transducers, Pressure
chemical_list: D018685:Anesthetics, Inhalation; D004986:Ether; D004737:Enflurane