title: Maleic acid is an aldose reductase inhibitor.
abstract: The effects of a series of dicarboxylic acids on aldose reductase activity were investigated in a crude enzyme preparation obtained from ocular lenses of the swine. Of the compounds examined, maleic acid inhibited aldose reductase in a pronounced manner and in a concentration-dependent fashion (IC50 value of 83.0 +/- 1.4 mM). Saturation experiments revealed non-competitive kinetics with a Ki value of 64.9 +/- 1.7 mM. The present results suggest that, at higher doses, maleic acid might have some implication for the treatment of diabetic complications.
authors.affiliation: Biorex Research and Development Co., Veszprém, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Hargitai
authors.forename: S L
authors.initials: SL
authors.lastname: Erdó
mesh_terms: D000449:Aldehyde Reductase / Q000009:adverse effects*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000737:chemistry; D008298:Maleates / Q000032:analysis / Q000494:pharmacology*; D009994:Osmolar Concentration; D013552:Swine
chemical_list: D004791:Enzyme Inhibitors; D008298:Maleates; C030272:maleic acid; D000449:Aldehyde Reductase