Cardiac troponin T: a noninvasive marker for heart transplant rejection?
BACKGROUND
Diagnosis of acute rejection remains a major concern in heart transplant recipients. Currently, endomyocardial biopsy is the gold standard for detecting rejection. Given the risks and cost of endomyocardial biopsy, a noninvasive marker for rejection would be ideal. Cardiac troponin T (cTnT) is an established marker of myocyte damage, and a rat transplantation model of heart transplant rejection has suggested that cTnT may be of value in detecting rejection.


METHODS
The cTnT levels were measured in 90 transplant recipients (67 men and 23 women) at the time of endomyocardial biopsy. There were a total of 256 cTnT levels and 256 biopsy samples. The cTnT levels were compared by use of International Society of Heart and Lung Transplantation rejection grades.


RESULTS
Only one of the 12 grade 3 biopsy specimens had a corresponding elevated cTnT level. Of the 29 biopsy specimens with myocyte necrosis (grade 2 or grade 3), three had a corresponding elevated cTnT. The cTnT levels were elevated during the first 1 to 2 months after transplantation. There was no correlation between ischemic time and cTnT levels.


CONCLUSIONS
CTnT is an insensitive marker of acute rejection, both early and late after heart transplantation. Elevation of cTnT after transplantation does not seem to be directly related to ischemic time.
Alexis
J D
JD
Department of Cardiothoracic Surgery, Cardiovascular Institute, Mount Sinai Medical Center, New York, NY 10029, USA.
Lao
C D
CD
Selter
J G
JG
Courtney
M C
MC
Correa
D K
DK
Lansman
S L
SL
Kushwaha
S S
SS
Gass
A L
AL
D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood*; D001706:Biopsy / Q000191:economics; D003365:Costs and Cost Analysis; D004195:Disease Models, Animal; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000145:classification / Q000175:diagnosis*; D016027:Heart Transplantation; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000737:chemistry / Q000473:pathology; D009336:Necrosis; D051381:Rats; D012307:Risk Factors; D013997:Time Factors; D014336:Troponin / Q000032:analysis / Q000097:blood*; D020107:Troponin T
D015415:Biomarkers; D014336:Troponin; D020107:Troponin T