Cardiovascular Effects of Bolus-Administered Vasodilators in Elderly Patients with Atherosclerotic Disease: A Comparative Study of Nitroglycerin and Prostaglandin E1
To evaluate the hemodynamic effects of vasodilators in elderly patients with atherosclerotic disease, systemic hemodynamics were examined during cardiac catheterization study. After the intravenous bolus injection of nitroglycerin (NTG, 5 µg/kg, n = 20) or prostaglandin E1 (PGE1, 0.2 µg/kg, n = 20), significant reduction of mean arterial pressure, pulmonary capillary wedge pressure (PCWP), systemic vascular resistance index (SVRI), and rate-pressure product (RPP) was observed. In contrast, cardiac index and stroke index were not significantly deteriorated in either group. In conclusion, bolus-administered NTG and PGE1 had beneficial vasodilating effects without harmful impact on cardiac functions in elder patients with atherosclerotic disease.
Utoh
J
First Department of Surgery, Kumamoto University School of Medicine, Kumamoto, Japan
Hirata
T
Kunitomo
R
Hara
M
Kitamura
N