Control of VSG gene expression sites in Trypanosoma brucei.
Antigenic variation in African trypanosomes continues to be one of the most elaborate and intriguing strategies ever devised by a protozoan parasite to avoid complete destruction by the immune defense of its mammalian host. Here we review some of the recent advances in our understanding of this strategy, concentrating on (unpublished) work from our laboratory.
Borst
P
P
Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam.
Bitter
W
W
Blundell
P A
PA
Chaves
I
I
Cross
M
M
Gerrits
H
H
van Leeuwen
F
F
McCulloch
R
R
Taylor
M
M
Rudenko
G
G
D000818:Animals; D000940:Antigenic Variation; D005786:Gene Expression Regulation; D015321:Gene Rearrangement; D017125:Genes, Protozoan; D011990:Receptors, Transferrin / Q000235:genetics; D014346:Trypanosoma brucei brucei / Q000235:genetics* / Q000276:immunology; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000235:genetics* / Q000276:immunology
D011990:Receptors, Transferrin; D014643:Variant Surface Glycoproteins, Trypanosoma