Prevention of cancer and cardiovascular diseases: a common strategy?
Cancer and cardiovascular diseases are two pathological states involving uncontrolled proliferation of either tumor or vascular smooth muscle cells. Interestingly, both types of disease can be prevented by the same type of chemical agent, such as marine polyunsaturated fatty acids, sulfur-containing compounds present in garlic, and wine polyphenols, among others, which seem to be fairly effective in the prevention of certain types of cancer and cardiovascular diseases. This is supported by numerous epidemiological studies and laboratory experiments involving animal models. It is therefore suggested that the mode of action of these compounds interfering with the development of these pathological states share some common trends. This could be taken into consideration in future studies related to the molecular mechanisms leading to these diseases as well as with the chemopreventive potential of some dietary components.
Argilés
J M
JM
Departament de Bioquímica i Biologia Molecular, Universitat de Barcelona, Spain. argiles@porthos.bio.ub.es
Carbó
N
N
Costelli
P
P
López-Soriano
F J
FJ
D002318:Cardiovascular Diseases / Q000517:prevention & control*; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*