title: A new cytosine glycoside from Streptomyces griseochromogenes produced by the use in vivo of enzyme inhibitors.
abstract: The identification of new cytosine glycosides and intermediates in the biosynthetic pathway of the antifungal antibiotic blasticidin S (1) was investigated using in vivo enzyme inhibition. Fermentations of Streptomyces griseochromogenes, the organism that produces 1, supplemented with the arginine analogue argininic acid or the argininosuccinate synthase inhibitor 2-methylaspartic acid were found to produce a new metabolite (7).
authors.affiliation: Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: S J
authors.initials: SJ
authors.lastname: Gould
authors.forename: T M
authors.initials: TM
authors.lastname: Zabriskie
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011744:Pyrimidinones / Q000737:chemistry / Q000378:metabolism*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D017550:Spectroscopy, Fourier Transform Infrared; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C112723:4-amino-1-(3-deoxygalacturonosyl)-2-pyrimidinone; D004791:Enzyme Inhibitors; D006603:Hexuronic Acids; D011744:Pyrimidinones