title: The multiple roles of macrophage scavenger receptors (MSR) in vivo: resistance to atherosclerosis and susceptibility to infection in MSR knockout mice.
abstract: Both type I and type II MSRs are integral membrane proteins containing a collagenous domain and elicit an extraordinarily wide range of ligand binding capability. They were found during the search for the molecule(s) responsible for the accumulation of modified LDL during atherogenesis. However, all prior the evidence relating to their physiological and pathophysiological roles in vivo had been indirect. Targeted disruption of the MSR gene results in a reduction in the size of atherosclerotic lesions in an apo E deficient animal. Macrophages from MSR deficient mice exhibit a marked decrease in modified LDL uptake in vitro, whereas modified LDL clearance from plasma remains normal, suggesting that there are alternative mechanisms for the uptake of modified LDL from the circulation. In addition, MSR knockout mice are more susceptible to L. monocytogenes and HSV-1 infection, indicating a role for MSR in host defense against various pathogens.
authors.affiliation: Exploratory Research Laboratory, Chugai Pharmaceutical Co. Ltd., Shizuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Kurihara
authors.forename: M
authors.initials: M
authors.lastname: Takeya
authors.forename: N
authors.initials: N
authors.lastname: Kamada
authors.forename: M
authors.initials: M
authors.lastname: Kataoka
authors.forename: K
authors.initials: K
authors.lastname: Jishage
authors.forename: H
authors.initials: H
authors.lastname: Sakaguchi
authors.forename: J K
authors.initials: JK
authors.lastname: Kruijt
authors.forename: T
authors.initials: T
authors.lastname: Higashi
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T J
authors.initials: TJ
authors.lastname: van Berkel
authors.forename: S
authors.initials: S
authors.lastname: Horiuchi
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Yazaki
authors.forename: T
authors.initials: T
authors.lastname: Kodama
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000502:physiology; D004198:Disease Susceptibility / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006561:Herpes Simplex / Q000235:genetics / Q000276:immunology; D008088:Listeriosis / Q000235:genetics / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology*; D051116:Receptors, Scavenger
chemical_list: D015815:Cell Adhesion Molecules; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger