CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress.
Oxidative stress is a pathogenic condition that causes cellular damage and, in a normally functioning cell, several transcription factors respond to this threat by modulating expression of genes whose products ameliorate the altered redox status in some way. We have isolated a novel macrophage scavenger receptor-like gene, CSR (cellular stress response), whose transcription in normal fibroblasts was significantly elevated by exposure to UV radiation or hydrogen peroxide, and pre-treatment with antioxidants prevented induction of CSR . Under conditions of oxidative stress, reactive oxygen species were significantly depleted in CSR -overexpressing cells, indicating that the CSR product protects cells by scavenging oxidative molecules or harmful products of oxidation. Further investigations into the regulation and function of CSR should open a way to understanding the cellular response and the pathogenic processes caused by oxidative stress.
Han
H J
HJ
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Tokino
T
T
Nakamura
Y
Y
D000595:Amino Acid Sequence; D016923:Cell Death; D002460:Cell Line; D002898:Chromosomes, Human, Pair 8; D018076:DNA, Complementary; D016166:Free Radical Scavengers; D005786:Gene Expression Regulation / Q000528:radiation effects; D006367:HeLa Cells; D006360:Heat-Shock Proteins; D006801:Humans; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D018384:Oxidative Stress; D011487:Protein Conformation; D011836:Radiation Tolerance / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D011971:Receptors, Immunologic / Q000737:chemistry* / Q000235:genetics* / Q000502:physiology; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D051122:Scavenger Receptors, Class B; D014466:Ultraviolet Rays; D015854:Up-Regulation
D018076:DNA, Complementary; D016166:Free Radical Scavengers; D006360:Heat-Shock Proteins; D008565:Membrane Proteins; D017382:Reactive Oxygen Species; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C112525:SCARA3 protein, human; C454739:Scarb1 protein, mouse; D051117:Scavenger Receptors, Class A; D051122:Scavenger Receptors, Class B