A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism.
The possible association of the DRD2 locus, and in particular the Taql-A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family-based sample. Neither the transmission/disequilibrium test nor the Affected Family-Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence.
Edenberg
H J
HJ
Indiana University School of Medicine, Indianapolis 46202-5122, USA.
Foroud
T
T
Koller
D L
DL
Goate
A
A
Rice
J
J
Van Eerdewegh
P
P
Reich
T
T
Cloninger
C R
CR
Nurnberger
J I
JI
Kowalczuk
M
M
Wu
B
B
Li
T K
TK
Conneally
P M
PM
Tischfield
J A
JA
Wu
W
W
Shears
S
S
Crowe
R
R
Hesselbrock
V
V
Schuckit
M
M
Porjesz
B
B
Begleiter
H
H
D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D002874:Chromosome Mapping; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008957:Models, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D012307:Risk Factors
D017448:Receptors, Dopamine D2