title: Venous thrombosis in a replanted finger with underlying factor V Leiden mutation.
abstract: Resistance to activated protein C (APC resistance) was described recently as a cause for thrombophilia. APC inactivates coagulation co-factors Va and VIIIa. A single base-pair mutation changing Arg506 to Gln at the APC cleavage site of the factor V gene leads to a factor V Leiden variant, which is the most frequent cause of APC resistance. Recently, its role in peripheral venous thrombosis during pregnancy was described. We here report a case with thrombosis of the venous anastomoses after finger replantation with resistance to activated protein C associated with factor V Leiden mutation.
authors.affiliation: Department of Neurosurgery, University School of Medicine, Graz, Austria.
authors.forename: L
authors.initials: L
authors.lastname: Kenner
authors.forename: F
authors.initials: F
authors.lastname: Schwarzl
authors.forename: H
authors.initials: H
authors.lastname: Moshammer
authors.forename: F
authors.initials: F
authors.lastname: Haas
authors.forename: G
authors.initials: G
authors.lastname: Hoefler
authors.forename: G
authors.initials: G
authors.lastname: Pierer
mesh_terms: D000328:Adult; D005165:Factor V / Q000235:genetics*; D005383:Finger Injuries / Q000601:surgery*; D006801:Humans; D008297:Male; D009154:Mutation; D011183:Postoperative Complications; D011486:Protein C / Q000502:physiology; D012092:Replantation; D013924:Thrombophlebitis / Q000235:genetics*
chemical_list: D011486:Protein C; C095381:factor V Leiden; D005165:Factor V