[The effect of antioxidant therapy on indicators of activity of free radicals in workers exposed to risks of styrene].
To 30 workers exposed to the risk of styrene for a period of 30 days a mixture of antioxidants was administered: vitamin C 200 mg, vitamin E 300 mg, selenium 20 mg, troxerutin 600 mg and beta-carotene 6 mg. Before the onset of supplementation and immediately afterwards laboratory indicators of antioxidant protection and lipid peroxidation were investigated. Before treatment workers exposed to the risk of styrene had a significantly higher malondialdehyde concentration (p < 0.01) and antioxidant capacity (p < 0.01) as compared with the control group. Due to the established positive correlation between these parameters (r = 0.42, p < 0.05) the findings can be evaluated as the result of increased exposure to free radicals. After supplementation a marked decline of the malondialdehyde concentration occurred p < 0.001) and a further rise of the antioxidant capacity (p < 0.001). The selenium concentration increased also markedly, the rise being more marked in subjects who had originally a lower concentration. There was a significant rise of uric acid which has an antioxidant effect (p < 0.01). The antioxidant enzymes superoxide dismutase and gluathione peroxidase did not change significantly. The results indicate the favourable effect of antioxidant treatment in subjects exposed to the risk of styrene.
Kaderábková
O
O
Klinika pracovního lékarství Fakultní nemocnice, Plzen.
Racek
J
J
Kohout
J
J
Holecek
V
V
Senft
V
V
Krejcová
I
I
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016273:Occupational Exposure; D012307:Risk Factors; D020058:Styrene; D013343:Styrenes / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D005609:Free Radicals; D013343:Styrenes; D020058:Styrene; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
Ovlivnĕní ukazatelů působení volných radikálů u pracovníků z rizika styrenu antioxidacní lécbou.