Ligand-free MHC class I conformation.
Perhaps the most important structural questions regarding MHC molecules concern what changes occur when the MHC molecule binds peptide. Extensive new biochemical evidence indicates that peptide-empty MHC class I molecules adapt an unstable and partially folded conformation.
Hansen
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D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D051379:Mice; D008954:Models, Biological; D011487:Protein Conformation
D015395:Histocompatibility Antigens Class I; D008024:Ligands