title: Perfusion and thallium single photon emission computed tomography in herpes simplex encephalitis.
abstract: This is the first report on 201thallium-single photon emission computed tomography (201Tl-SPECT) brain scan of a patient with herpes simplex encephalitis (HSE). The presented 201Tl-SPECT observations are correlated with 99mtechnetium hexamethylpropylene amine oxime (99mTc-HMPAO) perfusion SPECT and magnetic resonance imaging (MRI) findings. Brain 99mTc-HMPAO perfusion SPECT reveals a hyperperfusion in the right temporal lobe with extension to the parietal lobe and a hypoperfusion in the ipsilateral occipital lobe. 201Tl-SPECT shows a fixation in the right temporal lobe coinciding with the gadolinium enhancement on MRI. The right occipital lesion shown by gadolinium captation on MRI and hypoperfusion on 99mTc-HMPAO perfusion SPECT was not evident on the 201Tl SPECT. These findings could illustrate that the lesions might be different pathophysiologically.
authors.affiliation: Department of Neurology, General Hospital Middelheim, Antwerp, Belgium.
authors.forename: P P
authors.initials: PP
authors.lastname: De Deyn
authors.forename: P W
authors.initials: PW
authors.lastname: Van den Broucke
authors.forename: B A
authors.initials: BA
authors.lastname: Pickut
authors.forename: B
authors.initials: B
authors.lastname: Appel
authors.forename: R
authors.initials: R
authors.lastname: Crols
authors.forename: P
authors.initials: P
authors.lastname: Cras
authors.forename: J J
authors.initials: JJ
authors.lastname: Martin
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology / Q000528:radiation effects; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D013793:Thallium / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D013793:Thallium