title: Cutaneous malignant melanoma and oculodermal melanocytosis (nevus of Ota): report of a case and review of the literature.
abstract: A 29-year-old white man, with oculodermal melanocytosis, had a rapidly enlarging, erythematous, painful nodule over his left brow, within the nevus. The lesion was excised and diagnosed as a malignant melanoma. Systemic evaluation showed no evidence of distant disease. This is the tenth case reported of a cutaneous melanoma developing in a nevus of Ota. Melanoma arising in the choroid, brain, orbit, iris, ciliary body, or optic nerve in association with a nevus of Ota is well documented. Careful observation is necessary in patients with a nevus of Ota, particularly in white patients, in whom malignant degeneration seems to occur with a disproportionate frequency.
authors.affiliation: Department of Ophthalmology, University of Utah Health Sciences Center, Salt Lake City 84132, USA.
authors.forename: B C
authors.initials: BC
authors.lastname: Patel
authors.forename: C A
authors.initials: CA
authors.lastname: Egan
authors.forename: R W
authors.initials: RW
authors.lastname: Lucius
authors.forename: J W
authors.initials: JW
authors.lastname: Gerwels
authors.forename: N
authors.initials: N
authors.lastname: Mamalis
authors.forename: R L
authors.initials: RL
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002467:Cell Nucleus / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003593:Cytoplasm / Q000648:ultrastructure; D005138:Eyebrows / Q000473:pathology; D005143:Eyelids / Q000473:pathology; D005153:Facial Neoplasms / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D005546:Forehead / Q000473:pathology; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D058950:Melanoma-Specific Antigens; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009507:Nevus of Ota / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins