title: Central action of 9-methyl-7-bromoeudistomin D (MBED), a derivative of eudistomin D isolated from Eudistoma olivaceum.
abstract: The behavioral responses of mice following intracerebroventricular (i.c.v.) injection of 9-methyl-7-bromoeudistomin D (MBED) were studied. Head-twitches were produced 20-90 min after the injection of 2, 20 and 200 nmol/mouse but such twitches were not significantly induced by caffeine (1000 nmol/mouse). The locomotor activity, as assessed by the Animex autometer, increased 0-120 min after the injection with doses of 2, 20 and 200 nmol/mouse, whereas a large dose of caffeine (500 nmol/mouse also increased the activity counts. Simultaneous injection of picrotoxin (3 mg/kg, s.c.) and MBED (50, 100 and 200 nmol/mouse) produced clonic and tonic extensive convulsions, but caffeine (1000 nmol/mouse) in combination with picrotoxin did not cause any type of convulsion.
authors.affiliation: Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tadano
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: O
authors.initials: O
authors.lastname: Nakagawasai
authors.forename: K
authors.initials: K
authors.lastname: Tan-no
authors.forename: S
authors.initials: S
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Ohizumi
authors.forename: K
authors.initials: K
authors.lastname: Kisara
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
chemical_list: D002243:Carbolines; C060741:9-methyl-7-bromoeudistomin D