Linkage between inflammation and coagulation: an update on the molecular basis of the crosstalk.
Inflammation and coagulation cannot be considered as two separate processes, since there are several connecting points making them part of unique, defensive host response. The endothelium can be considered as the first link between inflammation and coagulation, since damaged endothelium during inflammation represents a surface where proteins involved in both coagulation and the development of inflammation are expressed. During inflammation, cytokines modulate the coagulation system by downregulating the expression of thrombomodulin and the activation of protein C pattern but, at the same time, they induce the expression of tissue factor, modifying, in this way, the balance between procoagulant and anticoagulant activities. At the same time, at the site of tissue injury, platelets become activated and release several mediators that modify tissue integrity. Thrombin, formed following activation of the coagulation cascade, is essential to promote haemostasis but also stimulates several cell functions, including chemotaxis and mitogenesis, which are responsible for the spreading of the lesion and the tissue repair process. Therefore, in the study of inflammation the involvement of the coagulation pathway has to be taken into account, since the interaction between coagulation and inflammation pathways is a critical issue.
Cicala
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Department of Experimental Pharmacology, University of Naples Federico II, Italy.
Cirino
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D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D011486:Protein C / Q000378:metabolism; D051381:Rats; D018179:Receptors, Thrombin / Q000378:metabolism; D015398:Signal Transduction
D011486:Protein C; D018179:Receptors, Thrombin