[Prognostic factors in stomach carcinoma].
The classical prognostic factors of the pTNM system are still most valid. Nevertheless, vascular invasion as well as the molecular marker E-cadherin proved to be independent new prognostic factors responsible for a significant shift in patient survival. Thus, in pTNM-stage II patients, a highly significant drop in survival is observed when patients showing no E-cadherin expression and at the same time vascular invasion are compared with E-cadherin-positive patients who do not show vascular invasion (Fig. 11). These conspicious shifts in survival underline the necessity to continue our search for new molecular and non-molecular markers which in future may help us to predict the outcome of gastric cancer patients more precisely and more individually.
Gabbert
H E
HE
Institut für Pathologie, Medizinische Einrichtungen der Heinrich-Heine-Universität, Düsseldorf.
Müller
W
W
Wirtz
C
C
Noguchi
T
T
D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000032:analysis*; D002448:Cell Adhesion; D006801:Humans; D018895:Microsatellite Repeats; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000503:physiopathology; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015820:Cadherins; D016159:Tumor Suppressor Protein p53
Prognosefaktoren beim Magenkarzinom.