title: Behavioral and monoaminergic changes after lindane exposure in developing rats.
abstract: The effects of lindane on behavior and central monoaminergic systems were studied in rat pups at 15 days of postnatal age. Pups were previously given nonconvulsant lindane PO doses, either a single 20 mg/kg or 7-day repeated 10 mg/kg doses. Both treatment schedules improved the passive avoidance acquisition but only the acute administration prolonged the step-through latency. Acute lindane decreased the motor activity, whereas the repeated dosing increased it. Increases of the ratio 5-HIAA/serotonin in several brain regions and of the ratio DOPAC/dopamine in the mesencephalon after a single dose of lindane suggest an enhanced monoaminergic turnover. In contrast, repeated lindane doses decreased monoamine/metabolite ratios excluding the striatum, where an increase of DOPAC/dopamine ratio correlates with the higher motor activity of these animals. It is postulated that both the imbalance of the central monoaminergic systems and the lindane-induced GABAergic blockade may be the basis of the behavioral alterations.
authors.affiliation: Department of Pharmacology and Toxicology, IIBB, CSIC, Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Rivera
authors.forename: R
authors.initials: R
authors.lastname: Rosa
authors.forename: E
authors.initials: E
authors.lastname: Martínez
authors.forename: C
authors.initials: C
authors.lastname: Suñol
authors.forename: M T
authors.initials: MT
authors.lastname: Serrano
authors.forename: M
authors.initials: M
authors.lastname: Vendrell
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez-Farré
authors.forename: C
authors.initials: C
authors.lastname: Sanfeliu
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D001362:Avoidance Learning / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism
chemical_list: D015306:Biogenic Monoamines; D007306:Insecticides; D012701:Serotonin; D001556:Hexachlorocyclohexane; D004298:Dopamine