[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia].
OBJECTIVE
To investigate if Cath-D, P-gp and Her-2 are correlated with prognosis in patients with cardiac carcinoma.


METHODS
Histological sections of 43 patients with cardiac cancer were tested by immunohistochemistry and analyzed for pathological type and lymphatic metastasis.


RESULTS
The research show and that P-gp and Her-2 were not significant in predicting lymphatic metastasis (P > 0.05), but Cath-D positive was significant in lymphatic metastasis (P < 0.01). The P-gp and Cath-D were not significant in differential level of cardiac carcinoma and expression of Her-2 was significant (P < 0.05).


CONCLUSIONS
The results suggest that positive Cath-D is correlated with metastases and positive Her-2 indicates poor survival. Special treatment plans for patients with carcinoma of the cardia should be designed depending on the above marker tests.
Zhang
L
L
Beijing Institute for Cancer Research.
He
L
L
Huang
X
X
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002299:Cardia; D002402:Cathepsin D / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014408:Biomarkers, Tumor; D002402:Cathepsin D; D018719:Erb-b2 Receptor Tyrosine Kinases