Reading within the lines: naturally processed peptides displayed by MHC class I molecules.
A typical mammalian cell contains tens of thousands of different gene products. Snippets of this genetic information are displayed on the cell surface by MHC class I molecules as short peptides for immune surveillance by CD8+ T lymphocytes. Genetic and biochemical analysis of these peptides is revealing novel sources and mechanisms by which these peptide/MHC class I complexes arise.
Shastri
N
N
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA. nshastri@socrates.berkeley.edu
Serwold
T
T
Paz
P
P
D017951:Antigen Presentation / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D010455:Peptides / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D010455:Peptides