Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease.
The murine Unp gene encodes a ubiquitin-specific protease, a member of a family of enzymes that includes the product of the human tre-2 oncogene. The Unp gene has previously been mapped to chromosome 9. We have cloned in bacteriophage a 50 kilobase region of chromosome 9 containing the Unp gene, and have determined the nucleotide sequence of the gene. The gene has 22 exons, distributed over 47.4 kb. A processed ribosomal S2 pseudogene was identified in the third intron of the Unp gene. Expression of Unp is driven by a GC-rich, 'housekeeping' type promoter.
Di Fruscio
M
M
Ottawa Regional Cancer Centre, 501 Smyth Road, Ottawa, Ontario, Canada.
Gilchrist
C A
CA
Baker
R T
RT
Gray
D A
DA
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA; D010450:Endopeptidases / Q000235:genetics* / Q000378:metabolism; D005091:Exons; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D015513:Oncogene Proteins; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins; D013379:Substrate Specificity; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases; D014452:Ubiquitins / Q000378:metabolism*
D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D014452:Ubiquitins; C082325:Usp4 protein, mouse; D004247:DNA; D010450:Endopeptidases; D043222:Ubiquitin Thiolesterase; D064570:Ubiquitin-Specific Proteases