title: Dose intensity in small cell lung cancer.
abstract: Evidence from preclinical models and from clinical trials describing the importance of dose intensity in securing a better treatment outcome is reviewed. Recent randomized trials have shown statistically significant survival benefits with higher-dose, accelerated chemotherapy regimens with and without granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. The novel use of peripheral blood progenitor cells contained in whole blood autotransfusions, which allow a marked increase in dose intensity of an ifosfamide/carboplatin/etoposide regimen, could provide a much easier method of delivering dose-intensive chemotherapy than previously available.
authors.affiliation: CRC Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK.
authors.forename: N
authors.initials: N
authors.lastname: Thatcher
authors.forename: S M
authors.initials: SM
authors.lastname: Lee
authors.forename: P J
authors.initials: PJ
authors.lastname: Woll
authors.forename: M
authors.initials: M
authors.lastname: Middleton
authors.forename: H
authors.initials: H
authors.lastname: Anderson
authors.forename: P
authors.initials: P
authors.lastname: Burt
authors.forename: R
authors.initials: R
authors.lastname: Stout
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000628:therapy
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor