Rapid SPME/LC/MS/MS analysis of N-methylcarbamate pesticides in water.
Solid-phase microextraction combined with fast short-column liquid chromatography/electrospray ionization tandem mass spectrometry (SPME/LC/MS/MS) was used for isolating and analyzing nine N-methylcarbamate pesticides from water samples. Several SPME parameters, such as polarity of fibers, extraction time, and effect of ionic strength, were investigated and their impact on the SPME/LC/MS/MS technique was studied. The method was shown to be sensitive with detection limits between 0.3 and 1.9 microg/L and reproducible with precision between 4.5 and 12.7% RSD. The versatility of the method was exhibited by its excellent linearity in the concentration range of 2-2,000 microg/L in drinking water. A comparison of the SPME/LC/MS/MS method with LC/MS/MS methods utilizing traditional sample preparation techniques shows that the former offers similar performance in terms of precision and linearity, but is clearly easier to use and faster to perform.
Volmer
D A
DA
Institute for Marine Biosciences, National Research Council, 1411 Oxford Street, Halifax, Nova Scotia B3H 3Z1, Canada.
Hui
J P
JP
D000327:Adsorption; D002219:Carbamates / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D009994:Osmolar Concentration; D010575:Pesticides / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012996:Solutions; D014877:Water Pollution, Chemical / Q000032:analysis*; D014881:Water Supply / Q000032:analysis
D002219:Carbamates; D010575:Pesticides; D012996:Solutions; C020401:N-methylcarbamate