title: Expression of Hex mRNA in early murine postimplantation embryo development.
abstract: The onset of Hex expression and its role in early murine development was analyzed using in situ hybridization. Hex mRNA was first detected in the chorion of the ectoplacental cavity and weakly at the visceral endoderm of the future yolk sac at embryonic age (E) 7.5. Expression in embryonic tissues was detected exclusively in the hepatic anlage and thyroid primordium at E 9.5. At E 12.5 and E 15.5, Hex expression persisted in the fetal liver and thyroid, and was also detected in the fetal lung. These results suggest that Hex has its role in differentiation and/or organogenesis of several embryonic tissues.
authors.affiliation: Department of Biochemistry, Fukui Medical University, Japan.
authors.forename: V W
authors.initials: VW
authors.lastname: Keng
authors.forename: K E
authors.initials: KE
authors.lastname: Fujimori
authors.forename: Z
authors.initials: Z
authors.lastname: Myint
authors.forename: N
authors.initials: N
authors.lastname: Tamamaki
authors.forename: Y
authors.initials: Y
authors.lastname: Nojyo
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D005865:Gestational Age; D018398:Homeodomain Proteins / Q000235:genetics*; D017403:In Situ Hybridization; D008099:Liver / Q000196:embryology / Q000502:physiology; D008168:Lung / Q000196:embryology; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000235:genetics; D013961:Thyroid Gland / Q000196:embryology; D014018:Tissue Distribution; D014157:Transcription Factors; D015017:Yolk Sac / Q000378:metabolism
chemical_list: C513080:Hhex protein, mouse; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D014157:Transcription Factors