The effect of an antiphlogistic incorporated in liposomes on experimentally induced inflammation.
The antiphlogistic Ibuprofen incorporated in liposomes caused a decrease of the inflammatory edema induced by Carrageenan in the distal part of the rat's hind leg after both the intramuscular and percutaneous administration. The antiphlogistic effect of free Ibuprofen in the cream was weaker. Intramuscular administration of empty liposomes slowed down in the initial stages the development of inflammation and slightly diminished the size of edema.
Schramlová
J
J
National Institute of Public Health, Prague, Czech Republic.
Blazek
K
K
Otová
B
B
Bartácková
M
M
Hulínská
D
D
D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D002351:Carrageenan; D003238:Connective Tissue / Q000473:pathology; D004337:Drug Carriers; D004487:Edema; D006614:Hindlimb; D007052:Ibuprofen / Q000008:administration & dosage* / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007273:Injections, Intramuscular; D008081:Liposomes; D008297:Male; D008684:Metatarsus; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D008081:Liposomes; D002351:Carrageenan; D007052:Ibuprofen