Unexpected late graft failure 9 months after HLA-identical bone marrow transplant (BMT) for chronic myeloid leukemia (CML): treatment with a second BMT.
We describe a patient with CML in 1st chronic phase (CP) who experienced a graft failure 9 months after an HLA genotypically identical sibling BMT. Drug toxicity, viral infections, chronic graft-versus-host-disease (GVHD) or leukemic relapse were excluded. Chimerism study showed 85% of donor marrow cells. She underwent a second BMT, reengrafted but died of grade IV acute GVHD.
Gil-Fernández
J J
JJ
Arranz
R
R
Cámara
R
R
Alegre
A
A
Figuera
A
A
Fernández-Rañada
J M
JM
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D005260:Female; D006084:Graft Rejection / Q000209:etiology*; D006086:Graft vs Host Disease / Q000209:etiology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000628:therapy*; D012086:Reoperation; D013997:Time Factors
D006680:HLA Antigens