title: Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43.
abstract: There is genetic predisposition associated with >=10% of all cancer of the prostate (CaP). By means of a genomewide search on a selection of 47 French and German families, parametric and nonparametric linkage (NPL) analysis allowed identification of a locus, on chromosome 1q42.2-43, carrying a putative predisposing gene for CaP (PCaP). The primary localization was confirmed with several markers, by use of three different genetic models. We obtained a maximum two-point LOD score of 2.7 with marker D1S2785. Multipoint parametric and NPL analysis yielded maximum HLOD and NPL scores of 2.2 and 3.1, respectively, with an associated P value of . 001. Homogeneity analysis with multipoint LOD scores gave an estimate of the proportion of families with linkage to this locus of 50%, with a likelihood ratio of 157/1 in favor of heterogeneity. Furthermore, the 9/47 families with early-onset CaP at age <60 years gave multipoint LOD and NPL scores of 3.31 and 3.32, respectively, with P = .001.
authors.affiliation: Département d'Urologie, Université Paris VII, Hôpital Saint Louis, Paris, France. p.berthon@chu-stlouis.fr
authors.forename: P
authors.initials: P
authors.lastname: Berthon
authors.forename: A
authors.initials: A
authors.lastname: Valeri
authors.forename: A
authors.initials: A
authors.lastname: Cohen-Akenine
authors.forename: E
authors.initials: E
authors.lastname: Drelon
authors.forename: T
authors.initials: T
authors.lastname: Paiss
authors.forename: G
authors.initials: G
authors.lastname: Wöhr
authors.forename: A
authors.initials: A
authors.lastname: Latil
authors.forename: P
authors.initials: P
authors.lastname: Millasseau
authors.forename: I
authors.initials: I
authors.lastname: Mellah
authors.forename: N
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authors.lastname: Cohen
authors.forename: H
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authors.lastname: Blanché
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authors.initials: C
authors.lastname: Bellané-Chantelot
authors.forename: F
authors.initials: F
authors.lastname: Demenais
authors.forename: P
authors.initials: P
authors.lastname: Teillac
authors.forename: A
authors.initials: A
authors.lastname: Le Duc
authors.forename: R
authors.initials: R
authors.lastname: de Petriconi
authors.forename: R
authors.initials: R
authors.lastname: Hautmann
authors.forename: I
authors.initials: I
authors.lastname: Chumakov
authors.forename: L
authors.initials: L
authors.lastname: Bachner
authors.forename: N J
authors.initials: NJ
authors.lastname: Maitland
authors.forename: R
authors.initials: R
authors.lastname: Lidereau
authors.forename: W
authors.initials: W
authors.lastname: Vogel
authors.forename: G
authors.initials: G
authors.lastname: Fournier
authors.forename: P
authors.initials: P
authors.lastname: Mangin
authors.forename: O
authors.initials: O
authors.lastname: Cussenot
mesh_terms: D017668:Age of Onset; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D011471:Prostatic Neoplasms / Q000235:genetics*