title: RNA-mediated signaling in transcription.
abstract: Structures of phage transcriptional antitermination complexes define novel motifs for recognition of RNA hairpins by arginine-rich peptides. A bent alpha-helix in each case follows the contour of an induced GNRA-like fold. A phage-specific pattern of base pairing, base stacking and base flipping underlies biological specificity and permits engagement with RNA polymerase. The structures suggest a mechanism of RNA-mediated signaling in transcriptional regulation.
authors.forename: M A
authors.initials: MA
authors.lastname: Weiss
mesh_terms: D000595:Amino Acid Sequence; D017100:Bacteriophage P22 / Q000235:genetics*; D010582:Bacteriophage lambda / Q000235:genetics*; D008954:Models, Biological; D008969:Molecular Sequence Data; D012319:RNA Polymerase II / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*; D015533:Transcriptional Activation
chemical_list: D012367:RNA, Viral; D012319:RNA Polymerase II