Indomethacin for prevention of heterotopic ossification after hip arthroplasty. A randomized comparison between 4 and 8 days of treatment.
In a randomized, parallel group study, we evaluated the efficacy of a 4-day versus an 8-day course of indomethacin (50 mg, 3 times per day), given as prophylaxis against heterotopic ossification after cementless total hip arthroplasty in 209 patients with arthrosis. Patients receiving the prophylaxis for 8 days had less (p = 0.03) severe heterotopic bone formation.
Dorn
U
U
Orthopedic Department, Salzburg General Hospital, Austria.
Grethen
C
C
Effenberger
H
H
Berka
H
H
Ramsauer
T
T
Drekonja
T
T
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D009999:Ossification, Heterotopic / Q000209:etiology / Q000517:prevention & control*; D015207:Osteoarthritis, Hip / Q000601:surgery; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin