title: Activity of lysosomal and nonlysosomal proteases and contents of protein and its degradation products in the blood serum of rats with fibrosarcoma induced by methylcholanthrene.
abstract: Activity of lysosomal and nonlysosomal proteases and contents of protein and its degradation products in the blood serum of rats with methylcholantrene fibrosarcoma were evaluated. Activity of lysosomal proteases and prolidase and prolinase as well in the blood serum of rats with methylcholanthrene tumour did not differ from the activity of these enzymes in the blood serum of control rats. Only the activity of elastase and collagenase in the blood serum of rats with methylcholanthrene tumour especially with tumour of intermediate and big mass was increased. Content of total protein was decreased in the blood serum of rats with tumour of intermediate and big mass and contents of glycoproteins and alfa-amin nitrogen were increased in comparison to the blood serum of control rats.
authors.affiliation: Department of Instrumental Analysis, Medical Academy of Białystok.
authors.forename: Z
authors.initials: Z
authors.lastname: Gołaszewski
authors.forename: J
authors.initials: J
authors.lastname: Pałka
authors.forename: K
authors.initials: K
authors.lastname: Sobolewski
authors.forename: H
authors.initials: H
authors.lastname: Ostrowska
authors.forename: J
authors.initials: J
authors.lastname: Gołaszewska
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001798:Blood Proteins / Q000032:analysis* / Q000378:metabolism; D002268:Carboxypeptidases / Q000097:blood / Q000378:metabolism; D002273:Carcinogens; D043402:Cathepsin A; D002401:Cathepsin B / Q000097:blood / Q000378:metabolism; D020789:Cathepsin C; D002402:Cathepsin D / Q000097:blood / Q000378:metabolism; D020059:Cathepsin E; D056649:Cathepsin G; D002403:Cathepsins / Q000097:blood / Q000378:metabolism; D017364:Collagenases / Q000097:blood / Q000378:metabolism; D004150:Dipeptidases / Q000097:blood / Q000378:metabolism; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000097:blood / Q000378:metabolism; D010450:Endopeptidases / Q000097:blood* / Q000378:metabolism; D005354:Fibrosarcoma / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D006023:Glycoproteins / Q000097:blood; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene; D009584:Nitrogen / Q000097:blood; D010196:Pancreatic Elastase / Q000097:blood / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000097:blood / Q000378:metabolism; D012878:Skin Neoplasms / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D001798:Blood Proteins; D002273:Carcinogens; D006023:Glycoproteins; D008748:Methylcholanthrene; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D002268:Carboxypeptidases; D002403:Cathepsins; D010450:Endopeptidases; D004150:Dipeptidases; C022454:prolyl dipeptidase; C022449:proline dipeptidase; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D020789:Cathepsin C; D043402:Cathepsin A; D012697:Serine Endopeptidases; D056649:Cathepsin G; C534097:Ctsg protein, rat; D010196:Pancreatic Elastase; D002401:Cathepsin B; D020059:Cathepsin E; D002402:Cathepsin D; D017364:Collagenases; D009584:Nitrogen