The selective antianginal effect without changing blood pressure of butylidenephthalide in conscious rats.
Synthetic butylidenephthalide (Bdph), 60 mg/kg per os (p.o.) given 3 h prior to injection of pituitrin (4 U/kg, i.v.), significantly prevented T-wave lowering on lead II electrocardiograph in unanesthetized rats. The effective dose, 60 mg/kg, was about 1/56th of the median lethal dose (LD50, p.o.) in rats. However, Bdph (60 mg/kg, p.o.) did not affect systolic pressure and heart rate in unanesthetized rats. Therefore, Bdph, found in the rhizome of Ligusticum chuaxiong Hort. (L. wallichii Franch., Umbelliferae), appears to have selective antianginal effect without changing blood pressure and heart rate.
Ko
W C
WC
Graduate Institute of Medical Sciences, Taipei Medical College, Taiwan, R.O.C. wc_ko@mail.tmc.edu.tw
Sheu
J R
JR
Tzeng
S H
SH
Chen
C M
CM
D000787:Angina Pectoris / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D010796:Phthalic Anhydrides / Q000494:pharmacology*; D010909:Pituitary Hormones, Posterior / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D010276:Parasympatholytics; D010796:Phthalic Anhydrides; D010909:Pituitary Hormones, Posterior; D010936:Plant Extracts; C026105:butylidenephthalide