title: Involvement of nitric oxide synthase in proteinuria associated with chronic renal disease in rats.
abstract: The present study demonstrates that the nitric oxide synthase inhibitor, aminoguanidine, can attenuate the proteinuria observed in a predominantly noninflammatory model of chronic renal disease in the rat. These data suggest that nitric oxide synthase may be involved in progressive renal disease.
authors.affiliation: Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Brooks
authors.forename: L C
authors.initials: LC
authors.lastname: Contino
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004791:Enzyme Inhibitors; D006146:Guanidines / Q000494:pharmacology; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000201:enzymology* / Q000652:urine; D008297:Male; D009392:Nephrectomy; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011507:Proteinuria / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004791:Enzyme Inhibitors; D006146:Guanidines; D003404:Creatinine; D019001:Nitric Oxide Synthase; C004479:pimagedine