title: Antibacterial activity of dentine primer containing MDPB after curing.
abstract: OBJECTIVE
  A monomer methacryloyloxydodecylpyridinium bromide (MDPB) has antibacterial activity before polymerization. Furthermore, the antibacterial agent is immobilized by the polymerization of MDPB and the resin-based material incorporating MDPB is able to show an antibacterial effect even after being cured. The purpose of this study was to investigate the antibacterial effect of a dentine primer containing MDPB after curing.
  
  
  METHODS
  The inhibitory effect of a cured MDPB-containing primer on the growth of Streptococcus mutans, Actinomyces viscosus and Lactobacillus casei was determined by the agar-disc method. The bactericidal activity of cured primer during a 1-h contact period was assessed using S. mutans, and the elution of unpolymerized MDPB was measured with high performance liquid chromatography.
  
  
  RESULTS
  Cured MDPB-containing primer showed an inhibitory effect on the growth of all species which were in contact with the specimen surface, and displayed a little bactericidal effect on S. mutans without releasing any unpolymerized antibacterial components.
  
  
  CONCLUSIONS
  Incorporation of antibacterial monomer MDPB into dentine primer is beneficial for providing antibacterial activity after curing.
authors.affiliation: Department of Operative Dentistry, Osaka, University Faculty of Dentistry, Japan. imazato@dent.osaka-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Imazato
authors.forename: A
authors.initials: A
authors.lastname: Ehara
authors.forename: M
authors.initials: M
authors.lastname: Torii
authors.forename: S
authors.initials: S
authors.lastname: Ebisu
mesh_terms: D016924:Actinomyces viscosus / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology*; D015169:Colony Count, Microbial; D017220:Dentin-Bonding Agents / Q000737:chemistry / Q000494:pharmacology*; D007778:Lactobacillus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000737:chemistry / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D017220:Dentin-Bonding Agents; D011726:Pyridinium Compounds; C089392:methacryloyloxydodecylpyridinium bromide