Behavioral effects of angiotensin II microinjected into CA1 hippocampal area.
The behavioral responses of rats to bilateral microinjections of angiotensin II (ATII) at doses of 0.1, 0.5 and 1.0 microg into the hippocampal CA1 area of male Sprague-Dawley rats were studied. ATII affected locomotor activity (the number of horizontal and vertical movements) in a dose-related U-shaped manner. In the elevated plus-maze experiments, ATII at a dose of 0.1 microg microinjected bilaterally into the CA1 hippocampal area increased the number of entries into the open arms, suggesting some anxiolytic effect.
Belcheva
I
I
Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia. irenata@iph.bio.acad.bg
Georgiev
V
V
Chobanova
M
M
Hadjiivanova
C
C
D000704:Analysis of Variance; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001007:Anxiety / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D051381:Rats; D017207:Rats, Sprague-Dawley; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D000804:Angiotensin II