title: Comparison of activity of 10 antibiotics against clinical strains of Helicobacter pylori by three different techniques.
abstract: The authors determined the susceptibility of 55 single clinical strains of Helicobacter pylori isolated in the Montreal area to 10 antibiotics by three different methods--an agar dilution technique considered to be the gold standard, a disk diffusion method and the E-test. Testing was performed on Mueller-Hinton agar supplemented with 10% sheep blood; plates were incubated at 37 degrees C for 72 h in a microaerophilic atmosphere. The metronidazole resistance rate is about 11% in the Montreal area. Macrolides are very active against H pylori isolates, with few variations in activity between older and newer molecules. Correlation among different methods was not as good as reported in the literature for metronidazole.
authors.affiliation: Department of Microbiology and Infectious Diseases, Hôpital Maisonneuve-Rosemont, University of Montreal, Québec. weiss@microim.umontreal.ca
authors.forename: K
authors.initials: K
authors.lastname: Weiss
authors.forename: M
authors.initials: M
authors.lastname: Laverdière
authors.forename: C
authors.initials: C
authors.lastname: Restieri
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D018942:Macrolides; D008826:Microbial Sensitivity Tests / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides