The effects of beta-carbolines in rats trained with ibogaine as a discriminative stimulus.
The structural features and hallucinogenic properties shared by ibogaine and certain beta-carbolines prompted the evaluation of several representative beta-carbolines in rats trained with ibogaine as a discriminative stimulus. In a previous report from our laboratory harmaline completely substituted for ibogaine (83.5%). In the present study, only 6-methoxyharmalan completely substituted (86.3%). However, partial substitution was observed with harmine, harmane, harmalol, and tetrahydro-beta-carboline (THBC). Norharmane and 6,7-dimethoxy-4-ethyl-carboline-3-carboxylate (DMCM) failed to produce appreciable substitution. These results provide evidence for an ibogaine-like ether this extends to the previously reported anti-addictive effects of ibogaine remains to be established.
Helsley
S
S
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA. shelsley@ubmedd.buffalo.edu
Rabin
R A
RA
Winter
J C
JC
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D004192:Discrimination, Psychological; D005795:Generalization, Stimulus; D006213:Hallucinogens; D006246:Harmaline / Q000494:pharmacology; D007050:Ibogaine; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D002243:Carbolines; D006213:Hallucinogens; D007050:Ibogaine; D006246:Harmaline