Solid phase synthesis of benzamidine and butylamine-derived hydantoin libraries.
We have constructed a number of benzamidine- and butylamine-based hydantoin compounds by means of an efficient route using solid phase synthesis in which neat diisopropylamine was employed for a novel cyclization/traceless cleavage step. All library compounds were obtained in excellent yield and high purity.
Kim
S W
SW
Biotech Research Institute, LG Chemical Ltd., Science Town, Taejon, Korea.
Koh
J S
JS
Lee
E J
EJ
Ro
S
S
D001550:Benzamidines / Q000138:chemical synthesis*; D002082:Butylamines / Q000378:metabolism; D006827:Hydantoins / Q000138:chemical synthesis*; D015394:Molecular Structure; D011437:Propylamines / Q000378:metabolism
D001550:Benzamidines; D002082:Butylamines; D006827:Hydantoins; D011437:Propylamines; C007442:diisopropylamine