title: Effect of HIV-1 infection on pregnancy outcome in women in Kigali, Rwanda, 1992-1994. Pregnancy and HIV Study Group.
abstract: OBJECTIVE
  To study the effect of HIV-1 infection on pregnancy outcome in women provided with antenatal services including malaria and sexually transmitted disease (STD) treatment in Kigali, Rwanda.
  
  
  METHODS
  Pregnant women attending the antenatal clinic ward of the Centre Hospitalier de Kigali in their last 3 months of pregnancy were tested for HIV antibody after consent had been obtained. All HIV-1-infected women were included and compared with HIV-negative women of same age and parity. Until delivery, each woman enrolled had a monthly follow-up including malaria and STD aetiological diagnosis and treatment. At the time of delivery, obstetrical and neonatal characteristics were recorded. Mothers and their children were followed until 6 weeks postpartum.
  
  
  RESULTS
  By mid-August 1993, 384 HIV-positive and 381 HIV-negative women had been enrolled and by the end of November 1993, 729 women (95.3%; 364 HIV-positive and 365 HIV-negative) had delivered 725 livebirths, including eight and six twins, respectively; 10 stillbirths were recorded amongst HIV-positive women and eight amongst HIV-negative women (P=0.60). Excluding twins, premature birth (< 37 completed weeks of gestation) was observed in 22.7% of infants born to HIV-positive women versus 14.1% of those born to HIV-negative women; low birth weight (< 2500 g) was observed in 25.5% of infants born to HIV-positive women versus 14.8% of those born to HIV-negative women. Low birth weight was significantly more frequent in full-term infants born to HIV-positive mothers than to HIV-negative mothers. No significant difference in low birth weight rate was observed in preterm infants. Death occurred in 5.1% of children during the perinatal period without statistically significant difference between the two groups. HIV-positive women were more likely to have a postpartum haemorrhage.
  
  
  CONCLUSIONS
  In the context of high HIV prevalence, maternal HIV infection is associated with adverse obstetrical and neonatal outcomes even when treating STD and malaria.
authors.affiliation: INSERM U330, Université Victor Segalen Bordeaux 2, France.
authors.forename: V
authors.initials: V
authors.lastname: Leroy
authors.forename: J
authors.initials: J
authors.lastname: Ladner
authors.forename: M
authors.initials: M
authors.lastname: Nyiraziraje
authors.forename: A
authors.initials: A
authors.lastname: De Clercq
authors.forename: A
authors.initials: A
authors.lastname: Bazubagira
authors.forename: P
authors.initials: P
authors.lastname: Van de Perre
authors.forename: E
authors.initials: E
authors.lastname: Karita
authors.forename: F
authors.initials: F
authors.lastname: Dabis
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications*; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D008288:Malaria / Q000188:drug therapy; D049590:Postpartum Period; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012307:Risk Factors; D012432:Rwanda; D012749:Sexually Transmitted Diseases / Q000188:drug therapy
chemical_list: D015483:HIV Antibodies