title: A new approach to oligonucleotide synthesis in solution.
abstract: A new approach to the synthesis of oligonucleotides and their phosphorothioate analogues in solution has been developed; it is based on H-phosphonate coupling and in situ sulfur-transfer.
authors.affiliation: Department of Chemistry, King's College London, Strand, UK.
authors.forename: C B
authors.initials: CB
authors.lastname: Reese
authors.forename: Q
authors.initials: Q
authors.lastname: Song
mesh_terms: D007202:Indicators and Reagents; D009841:Oligonucleotides / Q000138:chemical synthesis*; D063065:Organophosphonates; D012996:Solutions; D013455:Sulfur; D013873:Thionucleotides
chemical_list: D007202:Indicators and Reagents; D009841:Oligonucleotides; D063065:Organophosphonates; D012996:Solutions; D013873:Thionucleotides; D013455:Sulfur