A comparison of the therapeutic efficacy of conventional and modern oximes against supralethal doses of highly toxic organophosphates in mice.
1. The therapeutic efficacy of various oximes (pralidoxime, obidoxime, methoxime, HI-6, HLö-7, BI-6) against supralethal nerve agent poisoning (soman, sarin, cyclosin) in mice was tested. 2. New oxime BI-6, synthesized in our laboratory, is significantly more efficacious than conventional oximes but a little less efficacious than other H-oximes (HI-6, HLö-7). 3. H-oximes (HI-6, HLö-7) seem to be the most efficacious reactivators of nerve agent-inhibited acetylcholinesterase for antidotal treatment of supralethal nerve agent poisoning in mice.
Kassa
J
J
Purkynĕ Military Medical Academy, Hradec Králové.
D000818:Animals; D002619:Chemical Warfare Agents / Q000506:poisoning*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D062025:Organophosphate Poisoning; D010091:Oximes / Q000627:therapeutic use* / Q000633:toxicity
D002619:Chemical Warfare Agents; D010091:Oximes