[A study on the expression of three cytokine-receptors and airway hyperreactivity in asthmatics after specific provocation].
OBJECTIVE
In order to study the role of T and B lymphocytes activation in the pathogenesis of asthma.


METHODS
Pulmonary function tests were performed and percentages of three cytokine receptors and the levels of sIL-2R, sIgE and TIgE were measured in 31 allergic asthmatics and 12 healthy subjects before and after specific provocation.


RESULTS
It was found that the serum levels of sIL-2R (t = 5,719, 5,647 P < 0.01), TIgE were measured in 31 allergic asthmatics and 12 healthy (t = 6,306, 7,218 P < 0.01) and percentages of CD+23 (chi(2) -23.43, 18.56 P < 0.01) or CD+(25) (chi(2) = 27.59, 15. 28) cells were significantly higher in asthmatics after challenge than those in controls or in asthmatics before challenge as well; There were significantly negative correlations between sIL-2R and FEV1 or sGaw (r = -0.573, -0.426 P < 0.01), whereas positive correlations between sIL-2R and Raw or percent of IL-2R/CD+(25) cells (r = 0.417, 0.532 P < 0.01); TIgE and percent of Fc epsilon R II/CD+(23) cells (r = 0.603 P < 0.01), respectively.


CONCLUSIONS
These findings suggest that T cell activation, increased serum levels of sIL-2R and increased expression of CD+(25) or CD+(23) on cells, may lead to enhanced AHR in allergic asthmatics.
Chen
P
P
Respiratory Department, General Hospital of Shenyang Military District.
Lin
X
X
Dong
J
J
D000328:Adult; D000403:Airway Resistance; D001249:Asthma / Q000097:blood* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D017455:Receptors, IgE / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012129:Respiratory Function Tests
D017455:Receptors, IgE; D015375:Receptors, Interleukin-2; D007073:Immunoglobulin E