Herpes virus-like DNA (HHV-8) in immunosuppressive therapy-related, HIV-related and classical Kaposi's sarcoma in Norwegian patients.
The recently discovered human herpes virus 8 (Kaposi's sarcoma-associated herpes virus) has been implicated in the pathogenesis of Kaposi's sarcoma. Using polymerase chain reaction we detected DNA sequences of this herpes virus in 11 of 14 biopsy specimens from Kaposi's sarcoma in Norwegian patients, including the immunosuppressive therapy-related type (3 of 3), the HIV-related type (4 of 5), and the classical type (4 of 6). The results support the hypothesis of a role for human herpes virus 8 in all types of Kaposi's sarcoma independent of geographical area.
Jensen
P
P
Department of Dermatology, University of Oslo, Norway.
Huang
Y Q
YQ
Li
J J
JJ
Clausen
O P
OP
Friedman-Kien
A E
AE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D015658:HIV Infections / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D012514:Sarcoma, Kaposi / Q000139:chemically induced* / Q000453:epidemiology / Q000821:virology*; D012867:Skin / Q000737:chemistry / Q000473:pathology / Q000821:virology
D004273:DNA, Neoplasm; D004279:DNA, Viral; D007166:Immunosuppressive Agents