title: [Leukocyte and thrombocyte glycosaminoglycans in hemophilia A and von Willebrand's disease].
abstract: OBJECTIVE
  The study of glycosaminoglycanes (GAG) in leukocytes and platelets of patients with hereditary coagulopathy.
  
  
  METHODS
  GAG concentration, composition and fraction identification were made in 25 patients with hemophilia A and 10 patients with Willebrand disease.
  
  
  RESULTS
  In hemophiliacs, leukocytes contained low concentrations of GAG. In those with bleeding and synovitis GAG levels were lower than the average, in those with extensive hematomas in the absence of locomotor disorders the above levels were close to normal. Chondroitinsulphate dominated in GAG composition though it was less polydisperse. Heparin sulphate levels were elevated. Platelet GAG characteristics were close to normal. In Willebrand disease leukocyte GAG content and composition was similar to those in hemophilia A except some differences in electrophoretic properties of small GAG components.
  
  
  CONCLUSIONS
  Metabolism and/or release of GAG from blood cells may be involved in pathogenesis of hemophilia A and Willebrand disease.
authors.forename: M F
authors.initials: MF
authors.lastname: Kharchenko
authors.forename: L V
authors.initials: LV
authors.lastname: Egorova
authors.forename: E S
authors.initials: ES
authors.lastname: Bitiukova
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Tutova
authors.forename: N S
authors.initials: NS
authors.lastname: Nazarova
authors.forename: L P
authors.initials: LP
authors.lastname: Papaian
authors.forename: V D
authors.initials: VD
authors.lastname: Kargin
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000737:chemistry*; D002469:Cell Separation / Q000379:methods; D002648:Child; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006025:Glycosaminoglycans / Q000097:blood*; D006467:Hemophilia A / Q000097:blood* / Q000209:etiology; D006801:Humans; D007962:Leukocytes / Q000737:chemistry*; D008297:Male; D014842:von Willebrand Diseases / Q000097:blood* / Q000209:etiology
chemical_list: D006025:Glycosaminoglycans
vernacular_title: Glikozaminoglikany leĭkotsitov i trombotsitov pri gemofilii A i bolezni Villebranda.