[The role of human leukocyte antigen in susceptibility and clinical manifestations of sarcoidosis].
To investigate the association of human leukocyte antigen (HLA) with susceptibility and clinical manifestations of sarcoidosis. Fifty-five patients with sarcoidosis were studied by using allele group specific polymerase chain reaction technique (PCR). Our data show that: (1) the gene frequency of HLA-DR5 is significantly increased in patients with sarcoidosis, but that of HLA-DR7 decreased. (2) Gene frequencies of HLA-DR9 and HLA-DR5 are relatively increased in male patients and in patients with stage I and stage IIa, respectively. The results suggest that HLA-DR gene might contribute to the susceptibility as well as to the difference of clinical manifestations in sarcoidosis.
Xu
Z
Z
Department of Respiratory Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing.
Zhu
X
X
Zhao
Y
Y
D000328:Adult; D000368:Aged; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D059810:HLA-DR Serological Subtypes; D015805:HLA-DR5 Antigen / Q000235:genetics; D015809:HLA-DR7 Antigen / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000235:genetics / Q000276:immunology*; D012737:Sex Factors
D006680:HLA Antigens; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D015805:HLA-DR5 Antigen; D015809:HLA-DR7 Antigen; C038988:HLA-DR9 antigen