Effects of ranitidine or nocloprost on the selected gastric juice components in the patients with the gastric ulcer.
The 24 patients with gastric ulcer were treated ranitidine (2 x 150 mg daily) or nocloprost (2 x 200 micrograms daily). The effects of these drugs on the gastric juice components were measured. We evaluated hydrochloric acid, total protein, pepsin and some carbohydrates components secretion. We showed, that ranitidine decreased significantly total protein, fucose, N-acetylneuraminic acid and hexoses contents in the gastric juice in the basal secretion; the same tendency was observed in the pentagastrin-stimulated secretion. The similar direction of the changes, but weakly expressed was confirmed in the patients treated with nocloprost. It has been shown, that ranitidine modified the gastric mucin components content, what can suggest diminished degradation of mucus directly adhering to the gastric mucosa.
Skrodzka
D
D
Department of Gastroenterology, Medical Academy of Białystok.
Gabryelewicz
A
A
D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005260:Female; D005643:Fucose / Q000032:analysis; D005744:Gastric Acid / Q000737:chemistry / Q000378:metabolism; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D005752:Gastric Mucins / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006601:Hexoses / Q000032:analysis; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D019158:N-Acetylneuraminic Acid / Q000032:analysis; D010418:Pentagastrin; D010434:Pepsin A / Q000032:analysis / Q000187:drug effects; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*; D011506:Proteins / Q000032:analysis / Q000187:drug effects; D011899:Ranitidine / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000503:physiopathology
D000897:Anti-Ulcer Agents; D005752:Gastric Mucins; D005765:Gastrointestinal Agents; D006601:Hexoses; D006635:Histamine H2 Antagonists; D011461:Prostaglandins F, Synthetic; D011506:Proteins; D005643:Fucose; C048895:nocloprost; D011899:Ranitidine; D010434:Pepsin A; D010418:Pentagastrin; D019158:N-Acetylneuraminic Acid