[The realization of a conditioned avoidance reflex in rats under conditions of the multiple activation of the globus pallidus dopaminergic system].
Daily bilateral microinjections of 15 or 45 mcg of amphetamine into the globus pallidus of rats within three weeks inhibited the realization of conditioned avoidance in a shuttle-box. The dose of 15 mcg was most effective. There were no changes in locomotor activity. In contrast to the results obtained earlier in the experiments with similar neostriatal microinjections, no stimulatory dopaminergic effects (stereotyped behavior) were observed. The differences are discussed in the roles of the pallidal and neostriatal dopaminergic systems in regulation of behavior.
Iakimskiĭ
A F
AF
Pavlov Institute of Physiology, Russian Academy of Sciences, St.Petersburg.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D015259:Dopamine Agents / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology; D005917:Globus Pallidus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008845:Microinjections / Q000295:instrumentation / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical
D015259:Dopamine Agents; D011954:Receptors, Dopamine; D000661:Amphetamine
Realizatsiia uslovnogo refleksa izbeganiia u krys v usloviiakh mnogokratnoĭ aktivatsii dofaminergicheskoĭ sistemy blednogo shara.