title: The extended protein kinase C superfamily.
abstract: Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in a multitude of cellular processes, ranging from control of fundamental cell autonomous activities, such as proliferation, to more organismal functions, such as memory. However, understanding of mammalian PKC signalling systems is complicated by the large number of family members. Significant progress has been made through studies based on comparative analysis, which have defined a number of regulatory elements in PKCs which confer specific location and activation signals to each isotype. Further studies on simple organisms have shown that PKC signalling paradigms are conserved through evolution from yeast to humans, underscoring the importance of this family in cellular signalling and giving novel insights into PKC function in complex mammalian systems.
authors.affiliation: Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
authors.forename: H
authors.initials: H
authors.lastname: Mellor
authors.forename: P J
authors.initials: PJ
authors.lastname: Parker
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence / Q000235:genetics; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000737:chemistry; D015801:Helminth Proteins / Q000737:chemistry; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry; D008322:Mammals; D008969:Molecular Sequence Data; D011493:Protein Kinase C / Q000737:chemistry*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D005656:Fungal Proteins; D015801:Helminth Proteins; D007527:Isoenzymes; D011493:Protein Kinase C