Responses of intestinal and renal alpha-glycosidases to alloxan and streptozotocin-induced diabetes: a comparative study.
Experimentally induced diabetes in the rat resulted in an increased level of alpha-glycosidases in the intestine but a depression in their levels in the kidney. Rat intestine exhibited a differential stimulation of maltase, sucrase and trehalase activities. The variations depended on the duration of diabetes and the beta-cytotoxic compounds used i.e. alloxan and streptozotocin. The maximum elevation in terms of total units and specific activity was observed on the 30th day in the following order: maltase>sucrase>trehalase. A significant observation emerging from this study is that the level of intestinal enzymes increases while that of the kidney enzymes declined during the period. Although intestinal and renal alpha-glycosidases are known to be structurally and biochemically similar, their opposing responses to diabetes indicates that they are under different regulatory mechanisms in these tissues.
Sharma
S D
SD
Department of LifeSciences, University of Bombay, Vidyanagari, Santacruz(E), India.
Sivakami
S
S
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D015971:Gene Expression Regulation, Enzymologic; D005087:Glucan 1,4-alpha-Glucosidase / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism*; D007422:Intestines / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D008320:Maltose / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D008320:Maltose; D006026:Glycoside Hydrolases; D005087:Glucan 1,4-alpha-Glucosidase