Variations in insulin sensitivity in spontaneously hypertensive rats from different sources.
We investigated the possibility of variations in the genetic transmission of insulin sensitivity in the offspring of spontaneously hypertensive rats (SHRs) and Wistar Kyoto rats (WKYs) obtained from different sources (Charles River, Tokyo, Japan [NCrj]; and Funabashi Farm, Chiba, Japan [Izm]) with the insulin suppression test (IST) using a somatostatin analog, glucose, and insulin. The steady-state blood glucose (SSBG) in the IST and the glucose infusion required (GIR) in the euglycemic-hyperinsulinemic clamp differ significantly between obese and lean Zucker rats, indicating that both methods are useful for identifying insulin resistance. The fasting blood glucose and SSBG of the IST were significantly higher in SHR/Izm than in WKY/Izm. We did not observe a significant difference between SHR/NCrj and WKY/NCrj. These results indicate that the genetic transmission of hypertension and impaired insulin sensitivity may be variable and that insulin resistance does not play an important role in the pathogenesis of hypertension in the SHR.
Furukawa
L N
LN
Second Department of Internal Medicine/Department of Cardiology, Nihon University School of Medicine, Tokyo, Japan.
Kushiro
T
T
Asagami
T
T
Takahashi
A
A
Kanmatsuse
K
K
Ishikawa
K
K
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D001835:Body Weight / Q000235:genetics / Q000502:physiology; D005215:Fasting; D006339:Heart Rate / Q000235:genetics / Q000502:physiology; D006973:Hypertension / Q000235:genetics*; D007328:Insulin / Q000097:blood; D007329:Insulin Antagonists; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011924:Rats, Zucker
D001786:Blood Glucose; D007328:Insulin; D007329:Insulin Antagonists