Synthesis of echiguanine analogs and their ribofuranosyl glycosides that inhibit phosphatidylinositol 4-kinase.
N-carboxamide-substituted 7-deazaguanine-7-carboxamides and their ribofuranosyl compounds have been synthesized as phosphatidylinositol (PI) 4-kinase inhibitors. The ethylamide derivative and the corresponding ribofuranosyl compound inhibited PI 4-kinase with IC50 values of 0.02 and 2.4 micrograms/ml, respectively.
Saito
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Y
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Kato
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K
Umezawa
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K
D019870:1-Phosphatidylinositol 4-Kinase / Q000037:antagonists & inhibitors*; D002294:Carcinoma, Squamous Cell; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D004791:Enzyme Inhibitors; D006027:Glycosides; D007202:Indicators and Reagents; D011743:Pyrimidines; D011758:Pyrroles; D019870:1-Phosphatidylinositol 4-Kinase