Arenarins A-C: new cytotoxic fungal metabolites from the sclerotia of aspergillus arenarius
Three new terphenyl-type metabolites, arenarins A-C (1-3), have been isolated from the sclerotia of Aspergillus arenarius (NRRL 5012). The structures of these compounds were elucidated by analysis of 1-D and 2-D NMR data. Arenarins A-C exhibited mild activity in feeding assays against the dried-fruit beetle Carpophilus hemipterus and cytotoxicity against human tumor cell lines.
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Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, and Agricultural Research Service, National Center for Agricultural Utilization Research, USDA, Peoria, Illinois 61604, USA.
Gloer
JB
Wicklow
DT
Dowd
PF