title: Occupation and the risk of laryngeal cancer in Uruguay.
abstract: In a case-control analysis involving 112 patients afflicted by laryngeal cancer and 509 controls diagnosed with cancers not related to tobacco and alcohol exposures, we studied the effects of type of employment and of substances present in the workplace on laryngeal cancer risk. Effects were measured relative to those never employed or never exposed to the substances. All analyses were controlled for age, tobacco smoking, and alcohol drinking through unconditional logistic regression and stratified analysis. Among job titles, butchers, vintners, bakers, and car assemblers presented elevated risks of laryngeal cancer (OR for butchers 2.8, 95% CL 1.1-7.2). Similarly, asbestos, mists from strong inorganic acids and pesticide exposures were associated with increased risks of laryngeal cancer (OR for strong acids 1.8, 95% 1.1-2.9).
authors.affiliation: Registro Nacional de Cancer, Instituto Nacional de Oncologia, Montevideo, Uruguay.
authors.forename: E
authors.initials: E
authors.lastname: De Stefani
authors.forename: P
authors.initials: P
authors.lastname: Boffetta
authors.forename: F
authors.initials: F
authors.lastname: Oreggia
authors.forename: A
authors.initials: A
authors.lastname: Ronco
authors.forename: M
authors.initials: M
authors.lastname: Kogevinas
authors.forename: M
authors.initials: M
authors.lastname: Mendilaharsu
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D009790:Occupations / Q000706:statistics & numerical data; D016017:Odds Ratio; D012306:Risk; D012907:Smoking / Q000009:adverse effects; D014583:Uruguay / Q000453:epidemiology