title: Aluminum phthalocyanine tetrasulfonate in MCF-10F, human breast epithelial cells: a hole burning study.
abstract: Laser-induced holes are burned in the absorption spectrum of aluminum phthalocyanine tetrasulfonate (APT) in MCF-10F, human breast epithelial cells. The hole burning mechanism is shown to be nonphotochemical. The fluorescence excitation spectra and hole spectra are compared with those of APT in hyperquenched glassy films of water, ethanol, and methanol. The results show that the APT is in an acidic, aqueous environment with a hydrogen-bonded network similar to that of glassy water, but showing the influence of other cellular components. Pressure shifts of holes allow the local compressibility about the APT to be determined.
authors.affiliation: Ames Laboratory-USDOE and Department of Chemistry, Iowa State University, 50011, USA.
authors.forename: N
authors.initials: N
authors.lastname: Milanovich
authors.forename: T
authors.initials: T
authors.lastname: Reinot
authors.forename: J M
authors.initials: JM
authors.lastname: Hayes
authors.forename: G J
authors.initials: GJ
authors.lastname: Small
mesh_terms: D001940:Breast; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006801:Humans; D007211:Indoles / Q000633:toxicity*; D007834:Lasers; D009942:Organometallic Compounds / Q000633:toxicity*; D011838:Radiation-Sensitizing Agents / Q000633:toxicity; D013050:Spectrometry, Fluorescence
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C048577:aluminum tetrasulfophthalocyanine