title: Cell wall active antifungal compounds produced by the marine fungus hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation.
abstract: The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-15G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized medium, titers of the lipodepsipeptide and the polylactones reached approximately 200-400 mg/liter and 25-50 mg/liter, respectively. The optimum fermentation temperature for production of 15G256 gamma was 28 degrees C. Seawater appeared to have an inhibitory effect on metabolite accumulation at lower fermentation temperatures.
authors.affiliation: Natural Products Research, Wyeth-Ayerst Research, NY 10965, USA.
authors.forename: D
authors.initials: D
authors.lastname: Abbanat
authors.forename: M
authors.initials: M
authors.lastname: Leighton
authors.forename: W
authors.initials: W
authors.lastname: Maiese
authors.forename: E B
authors.initials: EB
authors.lastname: Jones
authors.forename: C
authors.initials: C
authors.lastname: Pearce
authors.forename: M
authors.initials: M
authors.lastname: Greenstein
mesh_terms: D000935:Antifungal Agents / Q000378:metabolism*; D002473:Cell Wall / Q000187:drug effects*; D005285:Fermentation; D013098:Xylariales / Q000145:classification* / Q000378:metabolism
chemical_list: D000935:Antifungal Agents