[Effect of carbon dioxide on peroxynitrite reaction with DNA].
Carbon dioxide has been reported to react with peroxynitrite (ONO2CO2-), altering the reactivity characteristic of peroxynitrite. We found that carbon dioxide caused a dose-dependent increase in 8-nitroguanine formation in calf thymus DNA incubated with peroxynitrite, whereas there was not apparent effect on 8-oxoguanine formation. In contrast, carbon dioxide inhibited peroxynitrite-induced strand breakage in plasmid pBR322 DNA and thymine-propenal formation from thymidine.
Ermilov
V
V
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Ishio
Iu
Iu
Oshima
Kh
Kh
D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology*; D002417:Cattle; D004247:DNA / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006147:Guanine / Q000031:analogs & derivatives / Q000096:biosynthesis; D009566:Nitrates / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects
C095838:8-nitroguanine; D009566:Nitrates; D002245:Carbon Dioxide; C039642:peroxynitric acid; C024829:8-hydroxyguanine; D006147:Guanine; D004247:DNA
Deĭstvie dvuokisi ugleroda na reaktsiiu peroksinitrita s DNK.