title: [Automatic image analysis of argentophil protein granule quantitative measurement on nucleolus area of limbus epithelial neoplasms].
abstract: OBJECTIVE
  To study the pathological diagnostic significance of argentophil protein (AgNOR) quantitative analysis at nucleolus area of limbus epithelial neoplasms.
  
  
  METHODS
  Automatic image analysis system was used for argentophil protein granule measurement in the pathologic diagnosis of 45 cases with limbus epithelial neoplasms, including benign hyperplasia, atypical hyperplasia, carcinoma in situ and squamous cell carcinoma.
  
  
  RESULTS
  In various lesions, there were the differences in the distributive pattern, size and area of AgNOR granules, which were closely related to the nature of the neoplasms (benign or malignant) and its cell differentiation.
  
  
  CONCLUSIONS
  Automatic image analysis of AgNOR quantitative measurement on limbus epithelial neoplasms may indicate the proliferative activity and cell differentiation in various lesions, help to differentiate benign or malignant neoplasms and effectively enhance the level of pathologic diagnosis.
authors.affiliation: Beijing Institute of Ophthalmology.
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Sun
mesh_terms: D002278:Carcinoma in Situ / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000473:pathology; D003316:Corneal Diseases / Q000473:pathology; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016850:Limbus Corneae; D011230:Precancerous Conditions / Q000473:pathology*