Aspirin-like drugs cause gastrointestinal injuries by metallic cation chelation.
Aspirin-like (nonsteroidal anti-inflammatory) drugs may cause injuries including ulcers to the gastrointestinal tract by chelation of the divalent and/or multivalent metallic cations in the gastrointestinal mucus and mucosa, as suggested by the chemical properties of these drugs and supported by experimental and clinical data.
Wang
X
X
Department of Pathology, Cornell University Medical College, New York, NY 10021, USA. xwang@mail.med.cornell.edu
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D001241:Aspirin / Q000633:toxicity*; D002412:Cations / Q000378:metabolism; D002614:Chelating Agents / Q000633:toxicity; D004064:Digestive System / Q000187:drug effects* / Q000293:injuries*; D004068:Digestive System Physiological Phenomena; D005744:Gastric Acid / Q000378:metabolism; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D009092:Mucous Membrane / Q000187:drug effects / Q000293:injuries / Q000502:physiology; D010437:Peptic Ulcer / Q000139:chemically induced; D011453:Prostaglandins / Q000494:pharmacology / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002412:Cations; D002614:Chelating Agents; D011453:Prostaglandins; D001241:Aspirin