Uptake of In-111 pentetreotide by pleural plaques.
Somatostatin receptor imaging with In-111 pentetreotide has been validated for the diagnosis and staging of chest tumors with neuroendocrine differentiation such as bronchial carcinoid and small cell lung cancer. In-111 pentetreotide uptake is not specific for neuroendocrine tumors because somatostatin receptors are also expressed by white blood cells, leading to the in vivo visualization sites of infection sites or active inflammation. Pleural plaques may be due to asbestos exposure or tuberculosis. Presented here are three cases of In-111 pentetreotide uptake in pleural plaques. This uptake by benign lesions may be misleading in the diagnostic work-up of patients with lung tumors.
Lonneux
M
M
Department of Nuclear Medicine, University of Louvain Medical School, Brussels, Belgium.
Jamar
F
F
Leners
N
N
Pieters
T
T
Pauwels
S
S
D000368:Aged; D001194:Asbestos; D001984:Bronchial Neoplasms / Q000000981:diagnostic imaging; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005355:Fibrosis; D006801:Humans; D007205:Indium Radioisotopes / Q000493:pharmacokinetics; D007962:Leukocytes / Q000378:metabolism; D008175:Lung Neoplasms / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging; D010994:Pleura / Q000000981:diagnostic imaging / Q000473:pathology; D010995:Pleural Diseases / Q000000981:diagnostic imaging*; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon; D014396:Tuberculosis, Pleural / Q000000981:diagnostic imaging
D007205:Indium Radioisotopes; D001194:Asbestos; D013004:Somatostatin; C081788:pentetreotide