title: Late onset of haze associated with viral keratoconjunctivitis following photorefractive keratectomy.
abstract: BACKGROUND
  To report a newly recognized cause of late onset of corneal haze following photorefractive keratectomy (PRK).
  
  
  METHODS
  A 35-year old woman who underwent uneventful PRK and subsequently developed viral keratoconjunctivitis 1 year after treatment.
  
  
  RESULTS
  During resolution of the viral keratoconjunctivitis, the patient developed extensive central corneal subepithelial infiltrates and anterior stromal fibrosis in the PRK ablation zone. More than 1 year after the initial infection, the central subepithelial fibrosis persisted, complicated by myopic regression, central steep island on videokeratography, and loss of five lines of spectacle-corrected visual acuity. By the end of the second year after the infection, visual acuity had improved with disappearance of the central steep island on videokeratography. However, the myopic regression and subepithelial fibrosis remained.
  
  
  CONCLUSIONS
  Patients who undergo PRK may be at greater risk of visual loss following viral keratoconjunctivitis secondary to persistent subepithelial infiltrates and/or stromal fibrosis within the PRK treatment zone.
authors.affiliation: Massachusetts Eye & Ear Infirmary, Boston 02114, USA.
authors.forename: R
authors.initials: R
authors.lastname: Pineda
authors.forename: J H
authors.initials: JH
authors.lastname: Talamo
mesh_terms: D000258:Adenovirus Infections, Human / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003318:Corneal Opacity / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D003319:Corneal Stroma / Q000473:pathology; D019781:Corneal Topography; D015828:Eye Infections, Viral / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D007637:Keratoconjunctivitis / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D054018:Lasers, Excimer; D009216:Myopia / Q000503:physiopathology / Q000601:surgery; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D014792:Visual Acuity
chemical_list: D000998:Antiviral Agents