title: Regeneration of axons from central neurons into microchips at the level of the spinal cord.
abstract: Axons from central neurons can regenerate into the tissue matrix formed within a silicone tube capped with two pieces of peripheral nerve, one of which had been sutured to a lesion in the spinal cord. Such axons can grow through a transversely positioned microchip in the tube. These observations suggest that it is feasible to establish functional contact between external electronic equipment and regenerating central nervous axons making it possible to monitor and control their electrical activity. The findings open new perspectives for restoration of motor and sensory functions following spinal cord lesions.
authors.affiliation: Department of Hand Surgery and Experimental Research, Malmö University Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Lundborg
authors.forename: J
authors.initials: J
authors.lastname: Drott
authors.forename: L
authors.initials: L
authors.lastname: Wallman
authors.forename: M
authors.initials: M
authors.lastname: Reimer
authors.forename: M
authors.initials: M
authors.lastname: Kanje
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology* / Q000254:growth & development; D005260:Female; D007150:Immunohistochemistry; D008838:Microcomputers; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000166:cytology* / Q000254:growth & development