title: Acid/base properties of beta-blockers and benzodiazepines in sodium dodecyl sulfate micelles. A spectrophotometric and potentiometric study.
abstract: The effect of sodium dodecyl sulfate (SDS) micelles on the acid-base properties of two family of pharmaceutical drugs (beta-blockers and benzodiazepines) at 25 degrees C and I = 0.1 M NaCl have been studied. The characterization of the several solution equilibria for the system drug/SDS micelle solution was performed by potentiometry and spectrophotometry, below and above the critical micelle concentration (cmc). Two widely used models have been applied to quantify the effect of micelles on the pKa of the drugs, and the results obtained point to different interactions of each family of drugs with the micelles.
authors.affiliation: CEQUP/Departamento de Química, Faculdade de Ciências, Universidade do Porto, Portugal.
authors.forename: B
authors.initials: B
authors.lastname: de Castro
authors.forename: P
authors.initials: P
authors.lastname: Gameiro
authors.forename: C
authors.initials: C
authors.lastname: Guimarães
authors.forename: J L
authors.initials: JL
authors.lastname: Lima
authors.forename: S
authors.initials: S
authors.lastname: Reis
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D001569:Benzodiazepines / Q000737:chemistry*; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D008956:Models, Chemical; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000319:Adrenergic beta-Antagonists; D008823:Micelles; D001569:Benzodiazepines; D012967:Sodium Dodecyl Sulfate