title: Sagittal diameter in comparison with single slice CT as a predictor of total visceral adipose tissue volume.
abstract: BACKGROUND
  Abdominal obesity has an important biological and epidemiological relationship to disease. The gold standard for measurement of visceral adipose tissue (VAT) is assessment by computerized tomography (CT) or magnetic resonance imaging (MRI), but because of simplicity and ease in collection, anthropometric variables are a desirable alternative to estimate VAT.
  
  
  OBJECTIVE
  To compare the abilities of a single slice CT scan through the L4-L5 interspace (L4-L5 VAT), sagittal diameter, and body mass index (BMI) to estimate total volume VAT. Total volume VAT (the gold standard) was measured by total abdominal CT scanning, with a mean of 42 CT slices per patient. Estimation of VAT in subjects of similar body size was emphasized.
  
  
  METHODS
  Retrospective study of subjects undergoing complete abdominal and pelvic CT scanning for clinical reasons.
  
  
  METHODS
  40 subjects (20 men and 20 women) mean age 56.5y, with a balanced selection for BMI < 27 and > 27.
  
  
  RESULTS
  In univariate regression models, L4-L5 VAT explained the largest proportion of the variance in total VAT (R2=0.87 [P<0.001]), though age (R2=0.11 [P=0.04]), BMI (R2=0.37 [P<0.001]), and sagittal diameter (R2=0.50 [P < 0.001]) were also statistically significantly related to total VAT. When limited to individuals with a BMI > or= 27 however, L4-L5 VAT explained a large proportion of the variance in total VAT (R2=0.87 [P < 0.001]) whereas sagittal diameter was only of borderline significance (R2=0.20 [P=0.06]), and BMI was not associated with total VAT (R2=0.04 [P=NS]). In multiple regression analyses, L4-L5 VAT area explained a large proportion of the variance (0.84-0.90), and once in the model, BMI, sagittal diameter, and age did not additionally contribute significantly to the explained variance in total VAT.
  
  
  CONCLUSIONS
  Abdominal sagittal diameter is poorly correlated to total VAT for men and women with a BMI > 27. Within a 2 cm range of sagittal diameter, there is nearly a three-fold variability in total VAT.
authors.affiliation: Department of Medicine, University of Pittsburgh School of Medicine, PA, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Schoen
authors.forename: F L
authors.initials: FL
authors.lastname: Thaete
authors.forename: S S
authors.initials: SS
authors.lastname: Sankey
authors.forename: J L
authors.initials: JL
authors.lastname: Weissfeld
authors.forename: L H
authors.initials: LH
authors.lastname: Kuller
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012189:Retrospective Studies; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed; D014781:Viscera