[Radiation and immunity. Contemporary view of old problems].
Some key problems of radiation immunology which were formulated during last decades have been considered. The possibility or their decision appeared at recent time proceeding from the new view on the ionizing irradiation as a source of biologically significant signals. From that point of view some experimental data concerning radiation effects on the maturation and selection of lymphocytes, contact interaction of immune system cells and cytokine network were reviewed. It was concluded that the disturbances of the spatial and temporary organization and integrative functions of immune system were the results of the non-adequate radiation-induced signalling.
Iarilin
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Institute of Immunology, Ministry of Public Health and Medical Industry of Russian Federation, Moscow.
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007109:Immunity / Q000528:radiation effects*; D008214:Lymphocytes / Q000528:radiation effects; D011839:Radiation, Ionizing; D015398:Signal Transduction / Q000528:radiation effects*; D013950:Thymus Gland / Q000528:radiation effects
D015815:Cell Adhesion Molecules; D016207:Cytokines
Radiatsiia i immunitet. Sovremennyĭ vzgliad na starye problemy.