title: Cladobotryal: a fungal metabolite with a novel ring system.
abstract: In screening for antifungal metabolites a novel compound, cladobotryal, was isolated from the mycoparasitic fungus Cladobotryum varium. Its structure was established as (+)-(2R*,3R*)-2-[(Z)-2-buten-2-yl]-3, 7-dihydro-3-formyl-3-methyl-5-phenylfuro[2,3-b]pyridin-4(2H)-one on the basis of spectroscopic evidence and single crystal X-ray analysis of its methyl hemiacetal. The fused furo[2,3-b]pyridinone skeleton of cladobotryal seems unprecedented within the chemical literature.
authors.affiliation: Novo Nordisk A/S, Bagsvaerd, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Breinholt
authors.forename: H C
authors.initials: HC
authors.lastname: Jensen
authors.forename: A
authors.initials: A
authors.lastname: Kjaer
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
authors.forename: B R
authors.initials: BR
authors.lastname: Rassing
authors.forename: C N
authors.initials: CN
authors.lastname: Rosendahl
authors.forename: I
authors.initials: I
authors.lastname: Søtofte
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification; D005658:Fungi / Q000737:chemistry*; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011728:Pyridones / Q000737:chemistry* / Q000302:isolation & purification; D014961:X-Ray Diffraction
chemical_list: C112140:2-(2-buten-2-yl)-3,7-dihydro-3-formyl-3-methyl-5-phenylfuro(2,3-b)pyridin-4(2H)-one; D000935:Antifungal Agents; D005663:Furans; D011728:Pyridones