A bioactive secosterol with an unusual A- and B-ring oxygenation pattern isolated from an Indonesian soft coral Lobophytum sp.
A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structures of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.
Morris
L A
LA
Department of Chemistry, University of Aberdeen, Scotland, U.K.
Christie
E M
EM
Jaspars
M
M
van Ofwegen
L P
LP
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012632:Secosteroids / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C112376:3,7,11-trihydroxy-5,6-epoxy-9,11-secogorgostan-9-one; D000970:Antineoplastic Agents; D012632:Secosteroids