Circulating levels of IGF-I in patients with chronic uremia on conservative dietary treatment.
The assessment of nutritional status is a very important step in the clinical management of chronic uremic patients, because of the influences of chronic renal failure and of dietary manipulations on the energy and protein metabolism. In this study some serum biochemical markers of protein nutrition, including IGF-I and pre-albumin, have been measured in chronic renal failure patients treated with two different low-protein diets, according to the residual renal function for several months. Our results showed no significant changes of IGF-I, pre-albumin or albumin serum levels in the patients treated with a very low-protein diet (0.3 g/Kg b.w. per day) supplemented with essential amino acids and ketoacids, in comparison with the patients on a conventional low-protein (0.6 g/Kg b.w. per day) diet.
Barsotti
G
G
Istituto Medicina Nucleare Università degli Studi di Pisa, Italia.
Cupisti
A
A
Ferdeghini
M
M
Meola
M
M
Battini
S
S
Cozza
V
V
Meriggioli
M
M
Barsotti
M
M
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D018753:Diet, Protein-Restricted; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000178:diet therapy; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D009752:Nutritional Status / Q000502:physiology; D011228:Prealbumin / Q000378:metabolism; D011863:Radioimmunoassay; D014511:Uremia / Q000097:blood / Q000178:diet therapy* / Q000209:etiology
D015415:Biomarkers; D004044:Dietary Proteins; D011228:Prealbumin; D007334:Insulin-Like Growth Factor I; D003404:Creatinine