[Exchange of vitamin D3 in placenta and fetal liver].
Metabolism of [3H]-vitamin D3 in placenta and fetus liver of rats on the 20-21st day of pregnancy was investigated. Biosynthesis in vivo of 25-hydroxyvitamin D3 occurs in placenta and fetus liver and the maximum observed 25-hydroxylation composes 15% in placenta and 13% in the fetus liver. It has been shown, that C-25-hydroxylation of vitamin D3 in the microsomal and mitochondrial fractions of hepatocytes take place. It has been concluded that placenta and fetus liver, although to not very much degree, is able to realize vitamin D3 metabolism independent of mother's organism.
Ivashkevich
S P
SP
A.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Shirankova
T G
TG
Nikiforova
T N
TN
D000818:Animals; D002112:Calcifediol / Q000096:biosynthesis*; D002762:Cholecalciferol / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D002762:Cholecalciferol; D002112:Calcifediol
Obmen vitamina D3 v platsente i pecheni ploda.