Transcriptional regulation of B-cell differentiation.
Transcription factors influence B cell differentiation by regulating the expression of numerous lineage-specific genes. Recent studies have identified factors that regulate differentiation of hematopoietic stem cells into B cell progenitors (PU.1 and lkaros), and further differentiation of these progenitors into mature B cells (NF kappa B, E2A, early B cell factor [EBF] and B cell specific activator protein [BSAP]). In addition, these studies demonstrate that complex interactions and redundancies among transcription factors safeguard the precise patterns of gene expression required for normal B cell differentiation.
Reya
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Howard Hughes Medical Institute Department of Microbiology and Immunology, University of California, San Francisco 94143-0414, USA.
Grosschedl
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D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation / Q000235:genetics; D005809:Genes, Regulator / Q000235:genetics*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout