title: Efficacy and safety of oral desmopressin in the treatment of primary nocturnal enuresis in Asian children.
abstract: OBJECTIVE
  To determine the efficacy and safety of oral desmopressin (DDAVP) treatment in Asian children with nocturnal enuresis.
  
  
  METHODS
  This was a multicentre randomized placebo-controlled double-blind cross-over study. Patients were randomized to either active treatment with oral 400 mg DDAVP or placebo, with a 2-week medication-free period between the cross-over. Children with primary monosymptomatic nocturnal enuresis, aged between 7 and 18 years, with a minimum frequency of wetting of 6 nights or more during a 2-week observation period were recruited. Efficacy was measured by reduction in the average number of wet nights per week.
  
  
  RESULTS
  Of the 37 children initially recruited, the outcomes for 34 children were included in the final cross-over analysis, as they had complete data for both the treatment periods. Statistical analysis by ANOVA showed that there was no significant difference between the medication-free period and the pretreatment period. However, the average number of wet nights per week for the DDAVP treatment period (2.5+/-2.7) was significantly lower than that of the placebo treatment period (4.5+/-2.1) (P < 0.0001). In terms of the safety profile, there was no significant change in bodyweight, blood pressure, serum sodium, serum osmolality, and urine osmolality following DDAVP treatment.
  
  
  CONCLUSIONS
  Oral DDAVP is a safe and efficacious drug for the short-term treatment of children with primary nocturnal enuresis.
authors.affiliation: Department of Paediatrics, National University Hospital, Singapore, Singapore.
authors.forename: H K
authors.initials: HK
authors.lastname: Yap
authors.forename: S M
authors.initials: SM
authors.lastname: Chao
authors.forename: A Y
authors.initials: AY
authors.lastname: Tan
authors.forename: B
authors.initials: B
authors.lastname: Murugasu
authors.forename: E K
authors.initials: EK
authors.lastname: Ong
authors.forename: E H
authors.initials: EH
authors.lastname: Low
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000704:Analysis of Variance; D001208:Asia; D002648:Child; D018592:Cross-Over Studies; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004775:Enuresis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D012076:Renal Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D012076:Renal Agents; D003894:Deamino Arginine Vasopressin