title: Clinical predictors of nephritis in systemic lupus erythematosus.
abstract: We identified clinical predictors of lupus nephritis presenting more than 6 months after the diagnosis of lupus in a cohort of 335 lupus patients. Almost 24% (80/335) of patients developed nephritis more than 6 months after the diagnosis of lupus. Using a Cox proportional hazards model, we found hypertension, thrombocytopaenia and leukopaenia to be associated with lupus nephritis presenting more than 6 months after diagnosis, with adjusted relative risks of 2.5 (95% CI 1.3 to 4.7), 4.3 (95% CI 1.7 to 10.8) and 3.2 (95% CI 1.7 to 6.2) respectively. In this cohort, hypertension, thrombocytopaenia and leukopaenia were associated with lupus nephritis presenting more than 6 months after the diagnosis of lupus.
authors.affiliation: Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
authors.forename: J
authors.initials: J
authors.lastname: Thumboo
authors.forename: K Y
authors.initials: KY
authors.lastname: Fong
authors.forename: H P
authors.initials: HP
authors.lastname: Chia
authors.forename: H H
authors.initials: HH
authors.lastname: Chng
authors.forename: E T
authors.initials: ET
authors.lastname: Koh
authors.forename: K H
authors.initials: KH
authors.lastname: Leong
authors.forename: W H
authors.initials: WH
authors.lastname: Koh
authors.forename: H S
authors.initials: HS
authors.lastname: Howe
authors.forename: K P
authors.initials: KP
authors.lastname: Leong
authors.forename: M L
authors.initials: ML
authors.lastname: Boey
authors.forename: P H
authors.initials: PH
authors.lastname: Feng
mesh_terms: D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology*; D015994:Incidence; D007970:Leukopenia / Q000150:complications / Q000453:epidemiology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis; D008181:Lupus Nephritis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011507:Proteinuria / Q000150:complications / Q000453:epidemiology*; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D012846:Singapore / Q000453:epidemiology; D013921:Thrombocytopenia / Q000150:complications / Q000453:epidemiology*