title: Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
authors.affiliation: Chemical and Physical Sciences and Inflammatory Diseases Research, The DuPont Merck Pharmaceutical Co., Experimental Station, Wilmington Delaware 19880-0500, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Cherney
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: D T
authors.initials: DT
authors.lastname: Meyer
authors.forename: C B
authors.initials: CB
authors.lastname: Xue
authors.forename: Z R
authors.initials: ZR
authors.lastname: Wasserman
authors.forename: K D
authors.initials: KD
authors.lastname: Hardman
authors.forename: P K
authors.initials: PK
authors.lastname: Welch
authors.forename: M B
authors.initials: MB
authors.lastname: Covington
authors.forename: R A
authors.initials: RA
authors.lastname: Copeland
authors.forename: E C
authors.initials: EC
authors.lastname: Arner
authors.forename: W F
authors.initials: WF
authors.lastname: DeGrado
authors.forename: C P
authors.initials: CP
authors.lastname: Decicco
mesh_terms: D015195:Drug Design; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020784:Matrix Metalloproteinase 8; D061965:Matrix Metalloproteinase Inhibitors; D008958:Models, Molecular; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D007769:Lactams; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D020784:Matrix Metalloproteinase 8