YM-47515, a novel isonitrile antibiotic from Micromonospora echinospora subsp. echinospora.
During the course of our screening for new antibiotics, Micromonospora echinospora subsp. echinospora Y-03559J was found to produce a novel isonitrile compound, YM-47515 (1) along with a probable degradation product 2. The structure of 1 was assigned by spectroscopic analysis including 2D NMR and IR experiments. The relative stereochemistry of 1 was also proposed by comparison of spectral data with those of a closely related compound aerocyanidin (3). YM-47515 (1) showed promising antimicrobial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
Sugawara
T
T
Chemistry Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan.
Tanaka
A
A
Imai
H
H
Nagai
K
K
Suzuki
K
K
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000737:chemistry* / Q000145:classification; D009570:Nitriles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009570:Nitriles; C111295:YM 47515