title: Optimized dose distribution of a high dose rate vaginal cylinder.
abstract: OBJECTIVE
  To present a comparison of optimized dose distributions for a set of high-dose-rate (HDR) vaginal cylinders calculated by a commercial treatment-planning system with benchmark calculations using Monte-Carlo-calculated dosimetry data.
  
  
  METHODS
  Optimized dose distributions using both an isotropic and an anisotropic dose calculation model were obtained for a set of HDR vaginal cylinders. Mathematical optimization techniques available in the computer treatment-planning system were used to calculate dwell times and positions. These dose distributions were compared with benchmark calculations with TG43 formalism and using Monte-Carlo-calculated data. The same dwell times and positions were used for a quantitative comparison of dose calculated with three dose models.
  
  
  RESULTS
  The isotropic dose calculation model can result in discrepancies as high as 50%. The anisotropic dose calculation model compared better with benchmark calculations. The differences were more significant at the apex of the vaginal cylinder, which is typically used as the prescription point.
  
  
  CONCLUSIONS
  Dose calculation models available in a computer treatment-planning system must be evaluated carefully to ensure their correct application. It should also be noted that when optimized dose distribution at a distance from the cylinder surface is calculated using an accurate dose calculation model, the vaginal mucosa dose becomes significantly higher, and therefore should be carefully monitored.
authors.affiliation: Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: J R
authors.initials: JR
authors.lastname: Palta
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation*; D003198:Computer Simulation; D004867:Equipment Design; D005260:Female; D006801:Humans; D009010:Monte Carlo Method; D011880:Radiotherapy Planning, Computer-Assisted; D014621:Vagina