Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats.
To investigate the role of Group I mGluRs in allodynia and hyperalgesia, we examined the behavioural responses of rats to noxious and non-noxious mechanical and thermal stimuli following intrathecal (i.t.) treatment (25 nmol) with the selective mGluR1/5 agonist, (RS)-dihydroxyphenylglycine ((RS)-DHPG). (RS)-DHPG administration produced a persistent decrease in response latency on a 48 degrees C hotplate, a reduction in the 50% response threshold to von Frey hairs, and an increase in responses to a tail pinch. These data suggest that activation of spinal mGluR1/5 receptors plays a role in the development of persistent allodynia and hyperalgesia associated with tissue or nerve injury.
Fisher
K
K
Pain Mechanisms Laboratory, Clinical Research Institute of Montreal, Quebec, Canada.
Coderre
T J
TJ
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002396:Catechols / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006930:Hyperalgesia / Q000139:chemically induced*; D007278:Injections, Spinal; D008297:Male; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors / Q000502:physiology*; D013314:Stress, Mechanical; D013696:Temperature
D002396:Catechols; D018094:Receptors, Metabotropic Glutamate; C099561:3,4-dihydroxyphenylglycine; D005998:Glycine