Purine nucleoside phosphorylase deficient mice exhibit both an age dependent attrition of thymocytes and impaired thymocyte differentiation.
Snyder
F F
FF
Department of Medical Genetics, Faculty of Medicine, University of Calgary, Alberta, Canada.
Jenuth
J P
JP
Mably
E R
ER
Mangat
R K
RK
Pinto-Rojas
A
A
D000375:Aging / Q000276:immunology; D000483:Alleles; D000818:Animals; D002454:Cell Differentiation; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D017354:Point Mutation; D011683:Purine-Nucleoside Phosphorylase / Q000172:deficiency* / Q000235:genetics*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000254:growth & development / Q000276:immunology*
D011683:Purine-Nucleoside Phosphorylase