title: [Risk factors and ways to avert early unfavorable outcomes in bronchial asthma].
abstract: OBJECTIVE
  Study of late outcomes of bronchial asthma (BA) and factors of risk of rapidly progressive BA course.
  
  
  METHODS
  A 10-year retrospective trial. Examination of 118 patients with BA aged 17-74 years.
  
  
  RESULTS
  A rapid progression of BA observed in 17(14%) patients led to an unfavorable outcome (death, life-threatening conditions, invalidism) as early as the first year of the observation. Relevant factors of risk were active eosinophil endobronchitis found at fibrobronchoscopy, concomitant active nonspecific infection in the bronchi, unjustified use of oral corticosteroids when inhalation steroids were possible, family problems.
  
  
  CONCLUSIONS
  Active secondary prophylaxis is necessary in patients at high risk of rapidly progressive BA.
authors.forename: S I
authors.initials: SI
authors.lastname: Ovcharenko
authors.forename: M V
authors.initials: MV
authors.lastname: Sheianov
authors.forename: V I
authors.initials: VI
authors.lastname: Makolkin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
vernacular_title: Faktory riska i puti predotvrashcheniia rannikh neblagopriiatnykh iskhodov bronkhial'noĭ astmy.