title: Persistent polyclonal B lymphocytosis with multiple bcl-2/IgH rearrangements: a benign disorder.
abstract: The appearance of a chronic B lymphocytosis is usually associated with the existence of an underlying monoclonal malignant condition. However, a few cases of persistent polyclonal B cell lymphocytosis (PPBL), presented in young asymptomatic women with an uneventful course, have been reported in recent years. In these PPBL cases, since the lymphocytes usually display an anomalous morphology, a false diagnosis of a neoplastic chronic lymphoproliferative syndrome can be easily made. We report a typical case of PPBL that presents multiple bcl-2 rearrangements, the typical finding of follicular lymphomas. A review of different causes of benign non neoplastic lymphocytosis with special steadiness in changes in the lymphoid subsets will be made.
authors.affiliation: Hematology Department, Hospital Universitario de La Princesa, Madrid, Spain. rgranados.ncm@ajemad.es
authors.forename: E
authors.initials: E
authors.lastname: Granados
authors.forename: P
authors.initials: P
authors.lastname: Llamas
authors.forename: I
authors.initials: I
authors.lastname: Pinilla
authors.forename: J F
authors.initials: JF
authors.lastname: Tomás
authors.forename: P
authors.initials: P
authors.lastname: Font
authors.forename: R
authors.initials: R
authors.lastname: Cámara
authors.forename: F
authors.initials: F
authors.lastname: Olmeda
authors.forename: R
authors.initials: R
authors.lastname: Arranz
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández-Rañada
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000166:cytology*; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008218:Lymphocytosis / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*
chemical_list: D007143:Immunoglobulin Heavy Chains; D019253:Proto-Oncogene Proteins c-bcl-2