Receptor editing and commitment in B lymphocytes.
B cells that fail to pass a developmental checkpoint, either as immature or mature B cells, can be rescued by creating a new B cell antigen receptor through nested secondary immunoglobulin gene rearrangements, a process termed receptor editing. Tolerance-mediated receptor editing occurs in self-reactive immature bone marrow B cells, while peripheral receptor editing probably occurs in low-affinity B cells competing for antigen and for survival signals within the germinal center response.
Hertz
M
M
Division of Basic Sciences, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
Nemazee
D
D
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation / Q000502:physiology; D004254:DNA Nucleotidyltransferases / Q000502:physiology; D015321:Gene Rearrangement / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000235:genetics*; D015398:Signal Transduction / Q000502:physiology; D045567:VDJ Recombinases
D007136:Immunoglobulins; D011947:Receptors, Antigen, B-Cell; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases