title: Effects of the 14F hemopump on coronary hemodynamics in patients undergoing high-risk coronary angioplasty.
abstract: BACKGROUND
  The influence of the 14F Hemopump on coronary hemodynamics in patients with coronary artery disease remains unknown.
  
  
  METHODS
  Systemic and coronary hemodynamic measurements were obtained in eight patients among 13 who underwent high-risk coronary angioplasty in our institution with the support of the Hemopump. Coronary blood flow velocity was measured with a 0.014-inch Doppler-tipped guide wire both proximal and distal to the target lesion.
  
  
  RESULTS
  Angioplasty decreases the diameter coronary stenosis from 76% +/- 21% to 22% +/- 11%. Hemopump support did not change systemic hemodynamics either before or after angioplasty. During angioplasty Hemopump support decreased the pulmonary capillary wedge pressure from 23.5 +/- 8.5 mm Hg to 18.6 +/- 7 mm Hg (p = 0.013). No changes in either heart rate, mean and systolic aortic pressures, and cardiac index were observed throughout the procedure. After successful angioplasty was performed, the ratio of proximal to distal flow velocity decreased from 2.11 +/- 1 to 1.65 +/- 0.2 (p = 0.05). However, Hemopump did not affect absolute coronary blood flow velocities or the phasic pattern of flow velocities (diastolic systolic velocity ratio, diastolic and systolic velocity integrals) either in proximal or distal locations either before or after angioplasty.
  
  
  CONCLUSIONS
  This study shows that although the 14F Hemopump produces unloading of the left ventricle, it does not importantly alter coronary hemodynamics when systemic hemodynamics are stable. Whether the Hemopump would maintain or improve coronary blood flow in compromised patients remains to be determined.
authors.affiliation: Service des Explorations Fonctionnelles, Fédération de Cardiologie et Centre de Recherche Chirurgical (CNRS), Hôpital Henri Mondor, Créteil, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Dubois-Randé
authors.forename: E
authors.initials: E
authors.lastname: Teiger
authors.forename: J
authors.initials: J
authors.lastname: Garot
authors.forename: E
authors.initials: E
authors.lastname: Aptecar
authors.forename: J M
authors.initials: JM
authors.lastname: Pernès
authors.forename: D
authors.initials: D
authors.lastname: Tixier
authors.forename: P
authors.initials: P
authors.lastname: Gueret
authors.forename: D
authors.initials: D
authors.lastname: Loisance
authors.forename: P
authors.initials: P
authors.lastname: Dupouy
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D001783:Blood Flow Velocity / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology / Q000628:therapy*; D003971:Diastole / Q000502:physiology; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D012307:Risk Factors; D013599:Systole / Q000502:physiology