Effects of dioxins and furans on liver enzymes, lipid parameters, and thyroid hormones in former thermal metal recycling workers.
A cross-sectional study was performed to examine the internal exposure of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDF) in former workers in a nonferrous metal recycling facility. Liver enzymes, lipid parameters, and thyroid hormones were measured to check possible biologic effects. Compared to background levels, the international toxicity equivalent levels of exposed workers were slightly elevated (median 42 ppt, range 13-281 ppt). The workers also had higher total PCDF concentrations (median 128 ppt, range 30-1138 ppt). Correlation analyses demonstrate significant associations with only one liver enzyme, alanine aminotransferase. There were no such associations with serum cholesterol levels or with serum thyroid hormones. Because of the cross-sectional design of the study, firm conclusions cannot be drawn. For further evaluation, a follow-up examination appears necessary.
Triebig
G
G
Institute and Policlinic of Occupational and Social Medicine, University of Heidelberg, Germany. gtriebig@krzmail.krz.uni-heidelberg.de
Werle
E
E
Päpke
O
O
Heim
G
G
Broding
C
C
Ludwig
H
H
D000328:Adult; D000368:Aged; D001572:Benzofurans / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D004147:Dioxins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007221:Industry; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008297:Male; D008670:Metals; D008875:Middle Aged; D016273:Occupational Exposure; D012037:Refuse Disposal; D013963:Thyroid Hormones
D001572:Benzofurans; D004147:Dioxins; D008055:Lipids; D008670:Metals; D013963:Thyroid Hormones