title: A bioactive secosterol with an unusual A- and B-ring oxygenation pattern isolated from an Indonesian soft coral Lobophytum sp.
abstract: A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structures of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.
authors.affiliation: Department of Chemistry, University of Aberdeen, Scotland, U.K.
authors.forename: L A
authors.initials: LA
authors.lastname: Morris
authors.forename: E M
authors.initials: EM
authors.lastname: Christie
authors.forename: M
authors.initials: M
authors.lastname: Jaspars
authors.forename: L P
authors.initials: LP
authors.lastname: van Ofwegen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007214:Indonesia; D009682:Magnetic Resonance Spectroscopy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012632:Secosteroids / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C112376:3,7,11-trihydroxy-5,6-epoxy-9,11-secogorgostan-9-one; D000970:Antineoplastic Agents; D012632:Secosteroids