Effects of compounds extracted from Tanacetum microphyllum on arachidonic acid metabolism in cellular systems.
In the present study, the effects of compounds extracted from Tanacetum microphyllum, four flavonoids and one sesquiterpene lactone, on arachidonic acid metabolism in cellular systems were examined. In the PGE2- and LTC4-release assay, most compounds did not exhibit any significant effect. Only hydroxyachillin, and the flavonoids centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol showed a significant effect, although with less potency than the reference drugs, indomethacin and NDGA. However, all compounds inhibited the release of TXB2 from ionophore-stimulated human platelets. The action is more marked with the flavonoids santin and ermanin.
Silván
A M
AM
Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.
Abad
M J
MJ
Bermejo
P
P
Villar
A
A
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D019659:Asteraceae / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D013931:Thromboxanes / Q000378:metabolism
D010936:Plant Extracts; D013931:Thromboxanes; D016718:Arachidonic Acid