title: Development of more efficacious antibodies for medical therapy and diagnosis.
abstract: Two procedures for improving the efficacy of medically important antibodies are described. The first procedure is designed to reduce the immunogenicity of nonhuman antibodies to the barest minimum--the "humanization" is accomplished by transplanting only the specificity-determining residues of the nonhuman antibody onto a human antibody template. The second procedure is designed to permit the easy production of multispecific/multivalent antibodies via heterodimer formation of electrostatically complementary Fc regions.
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Santos
authors.forename: E A
authors.initials: EA
authors.lastname: Padlan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000737:chemistry / Q000627:therapeutic use*; D000918:Antibody Specificity; D015195:Drug Design; D006801:Humans; D007135:Immunoglobulin Variable Region; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000737:chemistry / Q000627:therapeutic use; D013045:Species Specificity
chemical_list: D000906:Antibodies; D007135:Immunoglobulin Variable Region; D011994:Recombinant Proteins