title: Evaluation of endozepine-like immunoreactivity in the frontal cortex of suicide victims.
abstract: Diazepam-binding inhibitor (DBI) and its processing products, including the octadecaneuropeptide (ODN), are polypeptides called endozepines which have multiple biological effects, including regulation of mitochondrial steroidogenesis and modulation of GABA-gated chloride channels. Concentrations of ODN-like immunoreactivity (ODN-Li) were measured by radioimmunoassay in the frontal cortex of nine drug-free suicides and nine drug-free sudden-death victims. The level of ODN-Li was higher in the right than in the left frontal cortex, in both suicide (p < 0.05) and control (p < 0.02) subjects. No significant differences were found between suicides and controls either in the right and left cortex, or when considering the gender and the post-mortem diagnosis of depression.
authors.affiliation: Service Hospitalo-universitaire de Psychiatrie de l'Enfant et de l'Adolescent (69 I 02), CHS le Vinatier, BRON, France.
authors.forename: T
authors.initials: T
authors.lastname: Rochet
authors.forename: M C
authors.initials: MC
authors.lastname: Tonon
authors.forename: N
authors.initials: N
authors.lastname: Kopp
authors.forename: H
authors.initials: H
authors.lastname: Vaudry
authors.forename: S
authors.initials: S
authors.lastname: Miachon
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000032:analysis*; D016022:Case-Control Studies; D026261:Diazepam Binding Inhibitor; D005069:Evaluation Studies as Topic; D005260:Female; D005625:Frontal Lobe / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000032:analysis*; D010446:Peptide Fragments; D011863:Radioimmunoassay; D018709:Statistics, Nonparametric; D013256:Steroids / Q000096:biosynthesis; D013405:Suicide
chemical_list: D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor; D009479:Neuropeptides; D010446:Peptide Fragments; D013256:Steroids; C067529:diazepam binding inhibitor (33-50)