High density lipoprotein fatty acids in dementia.
High density lipoproteins (HDL) are small plasma particles which may be able to pass through the blood-brain barrier. We have therefore studied the fatty acids of HDL in patients with dementia to determine whether the changes are consistent with those previously reported in brain tissue. The HDL phospholipid and the HDL cholesteryl ester both showed reduced concentrations of arachidonic acid (20:4n6) as compared to normal controls. HDL may be a useful plasma fraction for study of lipids in neurodegenerative diseases.
Corrigan
F M
FM
Argyll and Bute NHS Trust, Argyll and Bute Hospital, Lochgilphead, UK.
Mowat
B
B
Skinner
E R
ER
Van Rhijn
A G
AG
Cousland
G
G
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000544:Alzheimer Disease / Q000378:metabolism / Q000523:psychology; D016718:Arachidonic Acid / Q000378:metabolism; D003627:Data Interpretation, Statistical; D003704:Dementia / Q000378:metabolism* / Q000523:psychology; D015118:Eicosapentaenoic Acid / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000737:chemistry / Q000378:metabolism
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008075:Lipoproteins, HDL; D010743:Phospholipids; D014280:Triglycerides; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid