A triazine dye, cibacron blue F3GA, decreases oxacillin resistance levels in methicillin-resistant Staphylococcus aureus.
Cibacron blue F3GA (CB) was found to reduce the MIC of oxacillin for methicillin-resistant Staphylococcus aureus (MRSA). This effect was not observed with methicillin-susceptible S. aureus. CB alters the resistance level of MRSA through a factor(s) other than mecA-related products, major autolysins, or femAB products. The exact target(s) of CB in causing the effect is unknown.
Shirai
C
C
Department of Internal Medicine II, Hiroshima University School of Medicine, Japan.
Sugai
M
M
Komatsuzawa
H
H
Ohta
K
K
Yamakido
M
M
Suginaka
H
H
D004347:Drug Interactions; D018432:Drug Resistance, Multiple; D016106:Methicillin Resistance / Q000502:physiology; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014227:Triazines / Q000494:pharmacology*
D010406:Penicillins; D011500:Protein Synthesis Inhibitors; D014227:Triazines; C012842:Cibacron Blue F 3GA; D010068:Oxacillin