[A trial of the use of the low-molecular heparin sulodexide in the therapy of diabetic nephropathy].
OBJECTIVE
Investigation of sulodexide effects on renal function, hemostasis and lipid metabolism in patients with diabetes mellitus.


METHODS
20 diabetics (diabetes mellitus type I and II) received sulodexide (Vessel due F) for 3 weeks. This mixture of low molecular heparin and dermatan sylphate was injected i.m. once a day for 5 days a week with a 2-day interval. Micro- and macro-albuminuria diminished after treatment but further returned to baseline levels. The rate of glomerular filtration, blood levels of glucose and cholesterol, hemostatic parameters remained unchanged. Blood triglycerides fell.


CONCLUSIONS
Sulodexide may be useful in pathogenetic treatment of diabetic nephropathy.
Zalevskaia
A G
AG
Astamirova
Kh S
KhS
Karpova
I A
IA
Popova
S G
SG
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006487:Hemostasis / Q000187:drug effects; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D008297:Male; D013997:Time Factors
D006025:Glycosaminoglycans; D006495:Heparin, Low-Molecular-Weight; D008055:Lipids; C007858:glucuronyl glucosamine glycan sulfate
Opyt primeneniia nizkomolekuliarnogo geparina sulodeksina v terapii diabeticheskoĭ nefropatii.