title: Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.
authors.affiliation: Oncology Research and Core Technology Area, Novartis Pharma Inc., CH-4002 Basel, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: García-Echeverría
authors.forename: P
authors.initials: P
authors.lastname: Furet
authors.forename: B
authors.initials: B
authors.lastname: Gay
authors.forename: H
authors.initials: H
authors.lastname: Fretz
authors.forename: J
authors.initials: J
authors.lastname: Rahuel
authors.forename: J
authors.initials: J
authors.lastname: Schoepfer
authors.forename: G
authors.initials: G
authors.lastname: Caravatti
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D051380:GRB2 Adaptor Protein; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011487:Protein Conformation; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D018909:src Homology Domains
chemical_list: C112415:3-amino-phenylmethoxycarbonyl-phosphotyrosyl-1-aminocyclohexanecarbonyl-asparaginamide; D048868:Adaptor Proteins, Signal Transducing; D051380:GRB2 Adaptor Protein; D008024:Ligands; D009842:Oligopeptides; D011506:Proteins