Induction of mesenchymal neoplasms by DMBA implantation in deep lingual submucosa of male albino rats.
45 male albino rats were used to study the effect of deep submucosal implantation of DMBA on lingual carcinogenesis. The results showed development of different mesenchymal neoplasms (fibroma, fibrosarcoma and leiomyosarcoma). So, this method of implantation could not be used as an ideal animal model for production of single known neoplasm as had been investigated by many investigators before.
Fathy
L M
LM
Faculty of Oral and Dental Medicine, Cairo University.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004195:Disease Models, Animal; D004343:Drug Implants; D005350:Fibroma / Q000139:chemically induced* / Q000473:pathology; D005354:Fibrosarcoma / Q000139:chemically induced* / Q000473:pathology; D007890:Leiomyosarcoma / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008637:Mesenchymoma / Q000139:chemically induced* / Q000473:pathology; D009061:Mouth Mucosa; D051381:Rats; D013997:Time Factors; D014062:Tongue Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D004343:Drug Implants; D015127:9,10-Dimethyl-1,2-benzanthracene