[Metabolism of purine compounds in psoriasis].
The pool of free purine derivatives and activities of the key enzymes of purine metabolism (adenosine deaminase, purine nucleoside phosphorylase, and 5'-nucleotidase) in lymphocytes, erythrocytes, and epidermis homogenates were measured in 20 normal subjects and 15 patients with psoriasis by high-performance liquid chromatography. The levels of AMP, GMP, and IMP purine monophosphates are decreased in the epidermis and red cells of psoriasis patients, whereas the final products of hypoxanthine, xanthine, and uric acid metabolism are accumulating, and the activities of ADA and PNP are increased double in the skin, all this indicating purine derivatives catabolism.
Tikhonov
Iu V
IuV
Markusheva
L I
LI
Toguzov
R T
RT
D000243:Adenosine Deaminase / Q000032:analysis / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D019271:Hypoxanthine / Q000378:metabolism; D009699:N-Glycosyl Hydrolases / Q000032:analysis / Q000097:blood; D011565:Psoriasis / Q000378:metabolism*; D011683:Purine-Nucleoside Phosphorylase / Q000032:analysis / Q000097:blood; D011687:Purines / Q000097:blood / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D014527:Uric Acid / Q000378:metabolism; D019820:Xanthine / Q000378:metabolism
D011687:Purines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D011683:Purine-Nucleoside Phosphorylase; D009699:N-Glycosyl Hydrolases; D000243:Adenosine Deaminase
Metabolizm purinovykh soedineniĭ pri psoriaze.