title: Expression of antimetastatic gene nm23-H1 in epithelial ovarian cancer.
abstract: OBJECTIVE
  To investigate the expression of nm23-H1 in epithelial ovarian cancer.
  
  
  METHODS
  A total of 55 specimens from patients with epithelial ovarian cancers, 15 patients with serous cancers, 7 with mucinous cancers, 17 with endometrioid cancers and 16 with adenocarcinomas, were examined for the expression of nm23-H1 by means of the immunohistochemical technique.
  
  
  RESULTS
  The total positive rate was 23.64% (13/55). The tissular nm23-H1 immunostaining had significantly higher expression in mucinous cancer (57.14%) than in other histologic types of epithelial ovarian cancer (P < 0.05). Compared to that in the primary tumor, nm23-H1 expression in the omental metastatic tumor in the same patient was reduced.
  
  
  CONCLUSIONS
  The expression rate of nm23-H1 is higher in the primary tumors than in the metastatic tumors and is different in various histologic subtypes of epithelial ovarian cancer. The expression of nm23-H1 may participate in the inhibitory process of tumor invasion.
authors.affiliation: Department of Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical University, China.
authors.forename: M
authors.initials: M
authors.lastname: Qian
authors.forename: Y
authors.initials: Y
authors.lastname: Feng
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: S
authors.initials: S
authors.lastname: Zheng
authors.forename: X
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D018269:Carcinoma, Endometrioid / Q000235:genetics*; D018282:Cystadenocarcinoma, Mucinous / Q000235:genetics*; D018284:Cystadenocarcinoma, Serous / Q000235:genetics; D005260:Female; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D006801:Humans; D008207:Lymphatic Metastasis; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D010051:Ovarian Neoplasms / Q000235:genetics*; D014157:Transcription Factors / Q000096:biosynthesis*
chemical_list: D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins