title: Intratympanic gentamicin treatment for Meniere's disease.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the safety and efficacy of a modified intratympanic gentamicin technique in patients with intractable unilateral or bilateral Meniere's disease.
  
  
  METHODS
  A retrospective review of 25 consecutive patients who underwent gentamicin treatment for Meniere's disease was conducted between 1992 and 1996. Two separate delivery systems were used during this study, with the last 13 subjects undergoing placement of the new system (flanged polyethylene tubing).
  
  
  RESULTS
  Follow-up averaged 23 months. Absence of vertigo spells was reported in 88%, and substantial control was achieved in 12%. Four of five patients with bilateral disease achieved complete control. Results for the two delivery systems were not significantly different. Absence of ice-water caloric response was seen in 75% (15 of 20) patients. Clinically significant sensorineural hearing loss occurred in 5 (20%) of 25 ears. Nonserviceable hearing developed in only two (8%) patients.
  
  
  CONCLUSIONS
  Our results support the previously reported efficacy and relative safety of gentamicin infusion therapy for intractable Meniere's disease. Polyethylene tubing may be more advantageous than T-tube delivery because of anatomic concerns in certain patients.
authors.affiliation: Department of Otolaryngology, University of Florida, Gainesville 32610-0264, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: McFeely
authors.forename: G T
authors.initials: GT
authors.lastname: Singleton
authors.forename: F J
authors.initials: FJ
authors.lastname: Rodriguez
authors.forename: P J
authors.initials: PJ
authors.lastname: Antonelli
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001301:Audiometry, Pure-Tone; D001302:Audiometry, Speech; D001844:Bone Conduction / Q000187:drug effects; D002150:Caloric Tests / Q000379:methods; D016503:Drug Delivery Systems; D004432:Ear, Middle; D004584:Electronystagmography; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006311:Hearing Disorders / Q000139:chemically induced; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced; D006801:Humans; D007053:Ice; D007440:Intubation / Q000295:instrumentation; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D008875:Middle Aged; D011095:Polyethylenes; D012189:Retrospective Studies; D012449:Safety; D013067:Speech Perception / Q000187:drug effects; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000601:surgery; D014717:Vertigo / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007053:Ice; D011095:Polyethylenes