[Nebulized drug aerosol systems].
To ensure the pulmonary absorption of medicines a developing technologist may choose from among several alternative possibilities. In the medical practice sprays made by mechanical spraying are of great importance. In this study depositions of fine mists made by OMRON ultrasonic nebulizer in Kirk Model apparatus were investigated. The absorption of sodium chloride (0.9% w/v) and theophylline (0.108 w/v) were monitored by chloride selective electrode and UV spectrophotometry, respectively. The aim of the study was to investigate how the nebulizer influences the deposition of medical mists. The results show that appropriate mist and ventillation produced by the OMRON nebulizer ensure the absorption of the medicines in the lung.
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Semmelweis Orvostudományi Egyetem Gyógyszerészeti Intézet, Budapest.
D000042:Absorption; D000336:Aerosols; D006801:Humans; D008168:Lung / Q000378:metabolism*; D009330:Nebulizers and Vaporizers; D012965:Sodium Chloride / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014465:Ultrasonics
D000336:Aerosols; D012965:Sodium Chloride
Porlasztott aeroszolos gyógyszerrendszerek.