Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia: measurement of local host responses.
Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-alpha and transforming growth factor-beta. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.
Franco
L
L
Corporacion para Investigaciones Biologicas, Medellin, Colombia.
Najvar
L
L
Gomez
B L
BL
Restrepo
S
S
Graybill
J R
JR
Restrepo
A
A
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004195:Disease Models, Animal; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006909:Hydroxyproline / Q000032:analysis; D008168:Lung / Q000737:chemistry / Q000382:microbiology / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010228:Paracoccidioides / Q000276:immunology*; D010229:Paracoccidioidomycosis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D013047:Specific Pathogen-Free Organisms; D016212:Transforming Growth Factor beta / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D006909:Hydroxyproline