[The effect of gidazepam on the cardiovascular system function in patients with neurotic reactions and in healthy subjects under aggravated conditions].
Administration of 0.05 g gidazepam once or twice daily for 7 days increased the stroke volume (SV) and circulation volume (CV) and reduced total peripheral resistance in neurotic patients. In healthy individuals 0.05 g gidazepam administered 60 min before an important examination stabilized CV. In subjects kept for 60 min in a microclimate with increasing temperature (55 +/- 2 degrees C, relative humidity 75-80%, rate of movement 1.5 m/min, rectal temperature at the end of exposure 39 degrees C) 0.05 g gidazepam administered 60 min before overheating optimally reorganized the reaction of the cardiovascular system, stabilized the SV at the initial level, which together with the growing heart rate increased the CV and provided sufficient perfusion of the vital organs. In healthy subjects working as operators for 4 h under conditions of hypercapnia (1.5% CO2), a single administration of 0.05 g gidazepam one hour before the beginning of work reduced the pulse pressure and increased the SV. The results obtained are evidence of the safety of using gidazepam as a corrector of emotion-induced disorders in operator performance under extreme conditions.
Morozov
I S
IS
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Barchukov
V G
VG
Neznamov
G G
GG
D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D009497:Neurotic Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D011603:Psychophysiology; D012016:Reference Values; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002316:Cardiotonic Agents; D001569:Benzodiazepines; C077010:gidazepam
Vliianie gidazepama na funktsional'noe sostoianie serdechno-sosudistoĭ sistemy bol'nykh s nevroticheskimi reaktsiiami i u zdorovykh lits v oslozhnennykh usloviiakh.