title: A fifth human cytomegalovirus glycoprotein B genotype.
abstract: Genetic variation in glycoprotein B (gB) may play a role in human cytomegalovirus (HCMV) pathogenesis. Using restriction endonuclease digestion and DNA sequencing, a unique gB genotype was identified in eight HCMV strains isolated from five patients with the acquired immune deficiency syndrome. Nucleic acid homology to the four previously described gB genotypes ranged from 79 to 91% for the two major variable regions of gB. Studies of the role of gB in HCMV pathogenesis should recognize the existence of live gB genotypes.
authors.affiliation: Department of Medicine, New York University School of Medicine, Manhasset 11030, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: Shepp
authors.forename: M E
authors.initials: ME
authors.lastname: Match
authors.forename: S M
authors.initials: SM
authors.lastname: Lipson
authors.forename: R G
authors.initials: RG
authors.lastname: Pergolizzi
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000821:virology*; D000595:Amino Acid Sequence; D001483:Base Sequence; D002460:Cell Line; D016384:Consensus Sequence; D003587:Cytomegalovirus / Q000235:genetics*; D003586:Cytomegalovirus Infections / Q000821:virology*; D004279:DNA, Viral; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D014759:Viral Envelope Proteins / Q000145:classification* / Q000235:genetics
chemical_list: D004279:DNA, Viral; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus; C040838:endodeoxyribonuclease MaeIII; D015252:Deoxyribonucleases, Type II Site-Specific