[The behavioral characteristics of rats induced by partial degeneration of the hippocampal cholinergic neurons].
The effects of intraventricular administration of ethylcholine aziridinium ion (AF64A) were studied in male Wistar rats. Bilateral injections of AF64A (3 nm/3 mcl) reduced the reactions to biological alarm signal and produced a decrease in the open-field activity 3 weeks after this lesion. The lesioned rats also displayed deficit in retention of a passive avoidance task.
Aĭrapetiants
M G
MG
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Shuĭkin
N N
NN
Levshina
I P
IP
D000818:Animals; D001388:Aziridines / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D005108:Extinction, Psychological / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009410:Nerve Degeneration / Q000139:chemically induced / Q000503:physiopathology*; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*
D001388:Aziridines; D011950:Receptors, Cholinergic; C044894:ethylcholine aziridinium; D002794:Choline
Osobennosti povedeniia krys, vyzvannye chastichnoĭ degeneratsieĭ kholinergicheskikh neĭronov gippokampa.