Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis.
Centrally given interleukin (IL)-1 is known to induce a rapid rises in blood IL-6. To extend this and to examine the mechanism by which this occurs, the effects of intracerebroventricular (i.c.v.) injection of human recombinant IL-1 beta on mRNA expression of IL-6 and tumour necrosis factor (TNF) in the spleen and liver were examined in rats. I.c.v. injection of IL-1 produced a rapid rise of the tissue mRNA levels of Il-6 and TNF in both organs, prior to and/or in parallel with an increase in their serum levels. Pretreatment with chlorisondamine, a ganglionic blocking agent, inhibited the Il-6 responses, while it had little influence on the TNF responses. The results suggest that brain IL-1 induces peripheral production of IL-6, but not of TNF, through autonomic nervous system activation.
Kitamura
H
H
Department of Biomedical Sciences, School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Okamoto
S
S
Shimamoto
Y
Y
Morimatsu
M
M
Terao
A
A
Saito
M
M
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D002714:Chlorisondamine / Q000008:administration & dosage; D005260:Female; D005730:Ganglionic Blockers / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage* / Q000502:physiology; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000378:metabolism
D005730:Ganglionic Blockers; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002714:Chlorisondamine