Serum cystatin C as a determinant of glomerular filtration rate in children.
The serum levels of cystatin C and creatinine were determined in a population comprising 69 children, 1-16 years old, and including children with both normal and reduced glomerular filtration rate (GFR) as determined by Cr-EDTA clearance measurement. The overall correlation between the reciprocal cystatin C concentration and GFR was significantly stronger (p < 0.05) than that between the reciprocal creatinine concentration and GFR and this was true also for the subpopulation of children with reduced GFR. Receiver-operating characteristic analysis also indicated superior diagnostic accuracy of serum cystatin C compared to that of serum creatinine for reduced GFR. The serum cystatin C reference values (mean +/- 1.96 SD) determined for children over one year of age was 0.63-1.33 mg/l, which is similar to that previously determined for adults. Serum cystatin C appears to be an attractive alternative to creatinine for estimation of GFR not only in adults, but also in children.
Helin
I
I
Department of Pediatrics, University Hospital, Lund, Sweden.
Axenram
M
M
Grubb
A
A
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D015853:Cysteine Proteinase Inhibitors / Q000097:blood*; D004492:Edetic Acid; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007118:Immunoassay; D007223:Infant; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis*; D008297:Male; D012372:ROC Curve; D012680:Sensitivity and Specificity
C525030:CST3 protein, human; D002860:Chromium Radioisotopes; D055316:Cystatin C; D015891:Cystatins; D015853:Cysteine Proteinase Inhibitors; D004492:Edetic Acid; D003404:Creatinine