Assessment of the effects of combination therapy with ciprofloxacin and fenbufen on the central nervous systems of healthy volunteers by quantitative electroencephalography.
The potential effects of concurrent administration of fenbufen and ciprofloxacin on central nervous system activity in healthy young subjects were investigated by electroencephalography (EEG). Visual analog scales (VAS) were used to assess subjective measures of concentration, vigilance, tension, and irritability. When ciprofloxacin was administered in combination with fenbufen, none of the EEG parameters or VAS ratings measured were significantly different from those measured when the drugs were administered alone.
Kamali
F
F
Wolfson Unit of Clinical Pharmacology, University of Newcastle, Newcastle upon Tyne, United Kingdom. farhad.kamali@ncl.ac.uk
Ashton
C H
CH
Marsh
V R
VR
Cox
J
J
D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D002939:Ciprofloxacin / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D010654:Phenylbutyrates / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D010654:Phenylbutyrates; D002939:Ciprofloxacin; C010725:fenbufen