title: Plasma and mucosal fatty acid pattern in colectomized ulcerative colitis patients.
abstract: Patients with inflammatory bowel disease (IBD) have increased plasma n3 polyunsaturated fatty acids (PUFAs), which in ulcerative colitis (UC) patients persists six months after colectomy, suggesting a primary abnormality in fatty acid (FA) metabolism in IBD. This finding needed to be confirmed in a larger series of UC long-term colectomized patients. We aimed to assess the plasma FA pattern in UC colectomized patients with either Brooke's ileostomy (UC-BI) or ileal pouch anal anastomosis (UC-IPAA) and the mucosal FA pattern in the ileal reservoir of the UC-IPAA patients. Plasma FAs were assessed in 63 UC colectomized patients (31 with BI and 32 with IPAA) and 30 controls. In 26 UC-IPAA (8 with pouchitis and 18 without pouchitis) and in 13 healthy controls gut mucosal FAs were also investigated. FAs were detected by capillary column gas-liquid chromatography. Increased levels of saturated fatty acids (SFAs) and decreased percentages of monounsaturated fatty acids (MUFAs) were observed in both groups of patients. There were no changes in plasma n3 and n6 PUFAs. The mucosal FA pattern of the ileal reservoir consisted of increased long-chain PUFAs, specially n6 PUFA, and a decrease of their essential precursors. High percentages of SFAs and low percentages of MUFAs were also seen. The plasma FA profile previously described in IBD is not observed long-term after colectomy in UC, suggesting that it is related with the presence of inflamed intestine. High concentrations of SFAs and decreased percentages of MUFAs might represent early events in disturbed FA metabolism in IBD. The changes in FAs of the ileal reservoir, which closely resemble those found in human and experimental IBD, probably represent a common pattern of intestinal inflammation.
authors.affiliation: Department of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Catalonia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Esteve
authors.forename: E
authors.initials: E
authors.lastname: Navarro
authors.forename: J
authors.initials: J
authors.lastname: Klaassen
authors.forename: A
authors.initials: A
authors.lastname: Abad-Lacruz
authors.forename: F
authors.initials: F
authors.lastname: González-Huix
authors.forename: E
authors.initials: E
authors.lastname: Cabré
authors.forename: E
authors.initials: E
authors.lastname: Ramos
authors.forename: E
authors.initials: E
authors.lastname: Condom
authors.forename: F
authors.initials: F
authors.lastname: Fernández-Bañares
authors.forename: C
authors.initials: C
authors.lastname: Pastor
authors.forename: P
authors.initials: P
authors.lastname: Humbert
authors.forename: J
authors.initials: J
authors.lastname: Martí-Ragué
authors.forename: M A
authors.initials: MA
authors.lastname: Gassull
mesh_terms: D000328:Adult; D000368:Aged; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000097:blood / Q000378:metabolism* / Q000601:surgery; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D016737:Proctocolectomy, Restorative
chemical_list: D005227:Fatty Acids