Determinants of the therapeutic efficacy of thymidylate synthase inhibitors.
Peters
G J
GJ
Department of Oncology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Kuiper
C M
CM
van Triest
B
B
Backus
H
H
van der Wilt
C L
CL
van Laar
J A
JA
Jansen
G
G
van Groeningen
C J
CJ
Pinedo
H M
HM
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D005472:Fluorouracil / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured
D000964:Antimetabolites, Antineoplastic; D004791:Enzyme Inhibitors; D013940:Thymidylate Synthase; D005472:Fluorouracil