[In situ hybridization to detect the mRNA for insulin-like growth factor-I and II in the prostate].
In order to well understand the expression of mRNA for insulin-like growth factor I and II in normal and hyperplastic prostate, in situ hybridization were used to detect them in a total of 35 cases of prostate. Both the normal and the hyperplastic prostate expressed the mRNA for IGF-I/II. The mRNA for IGF-I was mainly expressed by the epithelial cells and the IGF-II was mainly expressed by the stromal cells. The hyperplastic tissues expressed higher levels of the mRNA for IGF-I and IGF-II. The results suggested that the IGF might play an important role in the regulation of prostate growth and the pathogenesis of benign prostatic hyperplasia.
Deng
F
F
Institute of Urology, Beijing Medical University.
Zhao
X
X
Gu
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D006801:Humans; D017403:In Situ Hybridization; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis
D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II