Production of nontoxic lipid A by chemical modification and its antagonistic effect on LPS activity.
Tanamoto
K
K
Division of Microbiology, National Institute of Health Sciences, Tokyo, Japan.
D000107:Acetylation; D000818:Animals; D002240:Carbohydrate Sequence; D002460:Cell Line; D004926:Escherichia coli; D005260:Female; D006801:Humans; D008033:Limulus Test; D008050:Lipid A / Q000138:chemical synthesis*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008938:Mitosis / Q000187:drug effects; D008969:Molecular Sequence Data; D012475:Salmonella; D019802:Succinic Acid / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D008050:Lipid A; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D019802:Succinic Acid