title: Risk assessment in relation to neonatal metal exposure.
abstract: Rapid changes in organ development and function occur during the neonatal period. During this period the central nervous system is in a rapid growth rate and highly vulnerable to toxic effects of, e.g., lead and methylmercury. Furthermore, the kinetics of many metals is age-specific, with a higher gastrointestinal absorption, less effective renal excretion as well as a less effective blood-brain barrier in newborns compared to adults. Due to their low body weight and high food consumption per kg of body weight, the tissue levels of contaminants can reach higher levels in newborns than in adults. Generally, there is a low transfer of toxic metals through milk when maternal exposure levels are low. However, knowledge is limited about the lactational transport of metals and the potential effects of metals in the mammary gland on milk secretion and composition. There are some data from rodents on the lactational transfer and the uptake in the neonate of inorganic mercury, methylmercury, lead and cadmium. Metal levels in human breast milk and blood samples from different exposure situations can give information on the correlation between blood and milk levels. If such a relationship exists, milk levels can be used as an indicator of both maternal and neonatal exposure. Better understanding of the neonatal exposure, including kinetics in the lactating mother and in the newborn, and effects of toxic metals in different age groups is needed for the risk assessment. Interactions with nutritional factors and the great beneficial value of breast-feeding should also be considered.
authors.affiliation: Department of Food Hygiene, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Oskarsson
authors.forename: I
authors.initials: I
authors.lastname: Palminger Hallén
authors.forename: J
authors.initials: J
authors.lastname: Sundberg
authors.forename: K
authors.initials: K
authors.lastname: Petersson Grawé
mesh_terms: D000328:Adult; D002104:Cadmium / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007225:Infant Food; D007231:Infant, Newborn / Q000378:metabolism*; D007774:Lactation / Q000378:metabolism; D007854:Lead / Q000009:adverse effects / Q000493:pharmacokinetics; D008628:Mercury / Q000009:adverse effects / Q000493:pharmacokinetics; D008670:Metals / Q000009:adverse effects* / Q000493:pharmacokinetics; D008895:Milk, Human / Q000737:chemistry*; D018570:Risk Assessment; D014867:Water
chemical_list: D008670:Metals; D002104:Cadmium; D014867:Water; D007854:Lead; D008628:Mercury