Molecular mechanisms of yeast aging.
The life cycle of many organisms involves a progressive decline in fitness and fecundity with age, and yeast is no exception. Many theories have been proposed to explain the mortality of yeast cells, including the increase in cell size and accumulation of bud scars on the cell surface. None of these has survived closed scrutiny. However, recent discoveries might have validated one aging model in which the triggering of a molecular aging clock results in the replication and accumulation of a senescence factor that eventually overwhelms old cells.
Sinclair
D A
DA
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA. leng@mit.edu
Mills
K
K
Guarente
L
L
D004271:DNA, Fungal / Q000378:metabolism; D004275:DNA, Ribosomal / Q000378:metabolism; D005800:Genes, Fungal; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics / Q000254:growth & development
D004271:DNA, Fungal; D004275:DNA, Ribosomal