Costimulatory molecules (CD80 and CD86) on Reed-Sternberg cells are associated with the proliferation of background T cells in Hodgkin's disease.
To elucidate the relationship between Reed-Sternberg (R-S) cells and background T cells, the expression of CD80 and CD86 of R-S cells in Hodgkin's disease (HD), and the ligand CD28 expression and the MIB-1 index of background T cells were immunohistochemically investigated. CD80 and CD86 were found to be expressed on R-S cells in almost all cases of HD. CD28 was expressed with strong intensity on many background T cells around R-S cells. The MIB-1 index of background T cells was 30.3% (range, 15.5-38.9%) and was much higher than 10.9% (range, 9.8-11.7%) in B cell lymphomas. These results suggest that the interaction between CD80 and CD86 on R-S cells, and CD28 on background T cells may induce T cell proliferation and be associated with tumor mass of HD.
Nozawa
Y
Y
Department of Pathology, Fukushima Medical College, Japan. nozawa@cc.fmu.ac.jp
Wakasa
H
H
Abe
M
M
D015703:Antigens, CD / Q000378:metabolism*; D034961:Antigens, Nuclear; D018122:B7-1 Antigen / Q000378:metabolism*; D051940:B7-2 Antigen; D018106:CD28 Antigens / Q000378:metabolism; D017252:CD3 Complex / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D006689:Hodgkin Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D017493:Leukocyte Common Antigens / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism*; D016253:Microscopy, Immunoelectron; D009687:Nuclear Proteins / Q000378:metabolism; D016539:Reed-Sternberg Cells / Q000276:immunology*; D013601:T-Lymphocytes / Q000378:metabolism* / Q000473:pathology
D015703:Antigens, CD; D034961:Antigens, Nuclear; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D018106:CD28 Antigens; D017252:CD3 Complex; C497964:CD86 protein, human; D004268:DNA-Binding Proteins; D019394:Ki-67 Antigen; D008562:Membrane Glycoproteins; D009687:Nuclear Proteins; D017493:Leukocyte Common Antigens