Synthesis of some new biologically active 2,3-disubstituted quinazolin-4-ones.
The facile synthesis of 2-(2'-4-anisoylvinyl)-3-arylquinazolin-4-ones (2a, b) involves the condensation of 2-toluidine or 4-phenylenediamine with the corresponding 2-[2'-(4-anisoylvinyl)]-4H-3,1-benzoxazine-4-one (1). Reaction of compound 2 with aldehydes, bromine, alcohols, hydrazine hydrate, urea and thiourea are discussed. The former structure of the products have been characterized by elemental analysis and spectral data. Preliminary screening of some selected compounds for antimicrobial activity is reported.
Abdel-Rahman
T M
TM
Faculty of Specific Education, Abbassia, Cairo, Egypt.
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D007306:Insecticides / Q000138:chemical synthesis; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D042462:4-Quinolones; D000890:Anti-Infective Agents; D007306:Insecticides; D011799:Quinazolines