[Myocardial infarction in a pregnant woman during salbutamol therapy].
The authors report the case of a 31 year old woman at 30 weeks' gestation who developed a non-Q wave postero-lateral myocardial infarction during treatment with salbutamol. There were no complications and delivery took place at term normally. Coronary angiography was performed 3 months post-partum and was normal: the Methergin test was negative. Myocardial ischaemia occurring during treatment with a beta-2 mimetic in pregnancy is rare and hardly ever progresses to myocardial infarction. The usual mechanism of ischaemia is an imbalance of myocardial oxygen demand and supply. Myocardial oxygen consumption is naturally increased during pregnancy and excess intracellular calcium secondary to the beta-1 stimulation occurring with the use of beta-2 mimetic drugs further aggravates matters. This hypothesis raises the question of the value of calcium inhibitors in these forms of myocardial ischaemia.
Vermes
E
E
Service de cardiologie, centre hospitalier de Saint Germain-en-Laye.
Leroy
G
G
Halphen
C
C
Guyon
P
P
Labib
M
M
Stoltz
J P
JP
Haïat
R
R
D000033:Abortion, Threatened / Q000188:drug therapy; D000328:Adult; D000420:Albuterol / Q000009:adverse effects*; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000139:chemically induced*; D011263:Pregnancy Trimester, Third; D013566:Sympathomimetics / Q000009:adverse effects*
D013566:Sympathomimetics; D000420:Albuterol
Infarctus du myocarde chez une femme enceinte au cours d'un traitement par salbutamol.