title: Cardiovascular Effects of Bolus-Administered Vasodilators in Elderly Patients with Atherosclerotic Disease: A Comparative Study of Nitroglycerin and Prostaglandin E1
abstract: To evaluate the hemodynamic effects of vasodilators in elderly patients with atherosclerotic disease, systemic hemodynamics were examined during cardiac catheterization study. After the intravenous bolus injection of nitroglycerin (NTG, 5 µg/kg, n = 20) or prostaglandin E1 (PGE1, 0.2 µg/kg, n = 20), significant reduction of mean arterial pressure, pulmonary capillary wedge pressure (PCWP), systemic vascular resistance index (SVRI), and rate-pressure product (RPP) was observed. In contrast, cardiac index and stroke index were not significantly deteriorated in either group. In conclusion, bolus-administered NTG and PGE1 had beneficial vasodilating effects without harmful impact on cardiac functions in elder patients with atherosclerotic disease.
authors.affiliation: First Department of Surgery, Kumamoto University School of Medicine, Kumamoto, Japan
authors.initials: J
authors.lastname: Utoh
authors.initials: T
authors.lastname: Hirata
authors.initials: R
authors.lastname: Kunitomo
authors.initials: M
authors.lastname: Hara
authors.initials: N
authors.lastname: Kitamura