A magnetic evaluation of peripheral nerve regeneration: II. The signal amplitude in the distal segment in relation to functional recovery.
Motor and sensory function in a healthy nerve is strongly related to the number of neuronal units connecting to the distal target organs. In the regenerating nerve the amplitudes of magnetically recorded nerve compound action currents (NCACs) seem to relate to the number of functional neuronal units with larger diameters regenerating across the lesion. The goal of this experiment was to compare the signal amplitudes recorded from the distal segment of a reconstructed nerve to functional recovery. To this end, the peroneal nerves of 30 rabbits were unilaterally transected and reconstructed. After 6, 8, 12, 20, and 36 weeks of regeneration time the functional recovery was studied based on the toe-spread test, and the nerve regeneration based on the magnetically recorded NCACs. The results demonstrate that the signal amplitudes recorded magnetically from the reconstructed nerves increase in the first 12 weeks from 0% to 21% of the amplitudes recorded from the control nerves and from 21% to 25% in the following 23 weeks. The functional recovery increases from absent to good between the 8th and the 20th week after the reconstruction. A statistically significant relation was demonstrated between the signal amplitude and the functional recovery (P < 0.001). It is concluded that the magnetic recording technique can be used to evaluate the quality of a peripheral nerve reconstruction and seems to be able to predict, shortly after the reconstruction, the eventual functional recovery.
Kuypers
P D
PD
Department of Plastic and Reconstructive Surgery, Erasmus University Rotterdam, Faculty of Medicine, The Netherlands.
van Egeraat
J M
JM
van Briemen
L J
LJ
Godschalk
M
M
Hovius
S E
SE
D000818:Animals; D004594:Electrophysiology; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009416:Nerve Regeneration; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000502:physiology*; D010543:Peroneal Nerve / Q000502:physiology / Q000601:surgery; D011817:Rabbits; D013997:Time Factors