title: Pathophysiological and therapeutic considerations of otitis media with effusion from viewpoint of middle ear ventilation.
abstract: Using nitrous oxide, we examined the gas exchange function through the middle ear mucosa in ears with otitis media with effusion (OME) in children, and found the function to be impaired in 50% of them. The size of the mastoid was significantly smaller in ears with negative gas exchange function than those with positive function, and the presence or absence of the function was even more significantly correlated with the presence or absence of aeration in the middle ear. Furthermore, the presence or absence of aeration in ears with OME was found to be significantly correlated with their prognosis (response of OME to antibiotics treatment) and also with the presence or absence of eardrum mobility examined by a pneumatic otoscope. Finally, after myringotomy and removal of effusion, the gas exchange function recovered in most of the ears with impaired function. These results indicate that the eardrum mobility test may serve as an appropriate indicator for the surgical treatment for OME.
authors.affiliation: Department of Hearing and Speech Science, Kyoto University Graduate School of Medicine, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Honjo
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Sudo
authors.forename: K
authors.initials: K
authors.lastname: Ishijima
authors.forename: M
authors.initials: M
authors.lastname: Tanabe
mesh_terms: D002648:Child; D004432:Ear, Middle / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008876:Middle Ear Ventilation; D009092:Mucous Membrane / Q000503:physiopathology; D009609:Nitrous Oxide; D010034:Otitis Media with Effusion / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy
chemical_list: D009609:Nitrous Oxide