Antioxidant flavonoid glycosides from Daphniphyllum calycinum.
A novel flavonoid diglycoside, 5,6,7,4'-tetrahydroxyflavonol 3-O-rutinoside (1), and a previously known compound, kaempferol 3-O-neohesperidoside (2), were isolated from an ethyl acetate extract of Daphniphyllum calycinum leaves that showed significant activity in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay. The structure of 1 was elucidated by a combination of spectroscopic methods, and compounds 1 and 2 were found to be moderately active as antioxidants in the DPPH assay.
Gamez
E J
EJ
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Luyengi
L
L
Lee
S K
SK
Zhu
L F
LF
Zhou
B N
BN
Fong
H H
HH
Pezzuto
J M
JM
Kinghorn
A D
AD
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D002240:Carbohydrate Sequence; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D044948:Flavonols; D006569:Hesperidin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D044949:Kaempferols; D008969:Molecular Sequence Data; D010946:Plants, Medicinal / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D013057:Spectrum Analysis
C112733:5,6,7,4'-tetrahydroxyflavonol 3-O-rutinoside; D000975:Antioxidants; D004187:Disaccharides; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D044948:Flavonols; D044949:Kaempferols; C112732:kaempferol 3-O-neohesperidoside; D011794:Quercetin; D006569:Hesperidin