title: Immunohistochemical localization of Epstein-Barr virus receptor on hyperplastic gingiva of kidney allotransplant patient immunocompromised by cyclosporin A.
abstract: The strong association between Epstein-Barr Virus (EBV) and certain tumours of the oro-maxillo-laryngeal region aroused our present interest. A pre-requisite for the molecular interplay of oncogenesis by EBV is the expression of the EBV receptor on the target cell of the host. As a possible contribution to this concept, we adopted immunohistochemical technique to examine a hyperplastic gingival tissue obtained from a subject on kidney allotransplant immunosuppressed with cyclosporin A (CSA). Our results demonstrate expression of EBV/C3d receptor on the superficial layers of the hyperplastic gingiva but absent in the basal/parabasal layers. It is suggested that the superficial layer expression of EBV/C3d receptor could be due to direct acquisition from the environment of the oral cavity rather than a systemic extension from the deep layers of the same epithelium.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Nigeria.
authors.forename: J A
authors.initials: JA
authors.lastname: Akinwande
authors.forename: A A
authors.initials: AA
authors.lastname: Kazeem
authors.forename: E O
authors.initials: EO
authors.lastname: Taiwo
mesh_terms: D016572:Cyclosporine / Q000627:therapeutic use*; D005885:Gingival Hyperplasia / Q000378:metabolism*; D004854:Herpesvirus 4, Human; D006801:Humans; D016867:Immunocompromised Host / Q000502:physiology*; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000502:physiology*; D017464:Receptors, Complement 3d / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents; D017464:Receptors, Complement 3d; D011991:Receptors, Virus; D016572:Cyclosporine