title: Study of the maturation of the child's brain using 31P-MRS.
abstract: The maturation of human cerebrum and cerebellum in 37 normal children aged 4 months to 13 years 8 months was evaluated by 31P-magnetic resonance spectroscopy using two different conditions of repetition time (TR) (TR = 3 seconds and 15 seconds) in each region. The results were as follows. First, the PME/PDE, PCr/gamma-ATP and Pi/PCr ratios differed between the cerebrum and the cerebellum. The PME/PDE and PCr/gamma-ATP ratios were greater in the cerebellum than in the cerebrum. However, the Pi/PCr ratio was smaller in the cerebellum than in the cerebrum. At TR = 3 seconds, the ratio of (PME/PDE ratio in the cerebellum)/(PME/PDE ratio in the cerebrum) and the ratio of (PCr/gamma-ATP ratio in the cerebellum)/(PCr/gamma-ATP ratio in the cerebrum) manifested a nearly constant value independent of age. Second, the phosphomonoester peak in the cerebrum contained a substance with a longer relaxation time than 3 seconds; this substance was present in large amounts in the early period, then gradually decreased during maturation.
authors.affiliation: Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hanaoka
authors.forename: S
authors.initials: S
authors.lastname: Takashima
authors.forename: K
authors.initials: K
authors.lastname: Morooka
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis*; D000293:Adolescent; D002531:Cerebellum / Q000254:growth & development* / Q000378:metabolism; D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism; D002648:Child; D004734:Energy Metabolism; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D010725:Phosphocreatine / Q000032:analysis; D010759:Phosphorus Isotopes; D012016:Reference Values
chemical_list: D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D000255:Adenosine Triphosphate