Amplification and expression of the HMGIC gene in a benign endometrial polyp.
In a totally benign endometrial polyp, double minute chromosomes were shown to contain an amplified and apparently nonrearranged HMGIC gene, expressed in the tumor cells, suggesting amplification of HMGIC through double minute chromosome formation as another hitherto unreported mechanism associated with the development of some mesenchymal tumors.
Dal Cin
P
P
Center for Human Genetics, University of Leuven, Belgium.
Wanschura
S
S
Kazmierczak
B
B
Tallini
G
G
Dei Tos
A
A
Bullerdiek
J
J
Van den Berghe
I
I
Moerman
P
P
Van den Berghe
H
H
D002869:Chromosome Aberrations / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D025743:HMGA2 Protein; D006609:High Mobility Group Proteins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics; D011127:Polyps / Q000235:genetics* / Q000473:pathology
D025743:HMGA2 Protein; D006609:High Mobility Group Proteins; D009363:Neoplasm Proteins