[NF-kappa B and inflammatory intestinal diseases].
The chronic inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), are multifactorial pathologies. There is overwhelming evidence that genetic factors play a pivotal role in the predisposition to suffer from IBD. The severity of the inflammatory response depends on genes coding for proteins which regulate the cytokine production. Among them, NF kappa B stands out as the most important regulator of the gene expression of several pro- and anti-inflammatory genes. We present hereby its structure, function, regulation and the role played in IBD. Different theories relating the mechanism of action of glucocorticosteroids to NF kappa B are described in this review as well. The more accurate knowledge of the NF kappa B physiology has allowed new therapeutical approaches to inflammatory diseases to appear, namely the transfer to primary intestinal epithelial cells by an adenoviral vector of a mutant I kappa B (the inhibitory protein of NF kappa B) and the local use of p65 antisense phosphorothioate oligonucleotides.
Nosti-Escanilla
M P
MP
Departamento de Gastroenterología, Universidad Libre de Amsterdam, Países Bajos.
Peña
A S
AS
D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D016328:NF-kappa B / Q000235:genetics*
D016328:NF-kappa B
NF kappa B y enfermedad inflamatoria intestinal.