title: [Evaluation of combination RU 486-laminaria tents-misoprostol-peridural anesthesia in second and third trimester induced abortions].
abstract: OBJECTIVE
  To evaluate a new protocol for mid and third trimester medical termination of pregnancy using RU 486-misoprostol-epidural analgesia.
  
  
  METHODS
  Monocentric, prospective and descriptive study in a teaching hospital.
  
  
  METHODS
  Eighty-three women undergoing legal induced abortion during the second and third trimester. Administration of 600 mg mifepristone 36 hours prior to laminaria tents. 48 hours after RU 486, misoprostol was orally given on a 3 hours basis. Epidural analgesia was systematically performed.
  
  
  METHODS
  Induction-abortion interval, median dose of misoprostol, maternal complications, number of fetal autopsies obtained within 24 hours.
  
  
  RESULTS
  The mean induction abortion interval was 3 h for multiparas and 4.45 h for nulliparas. The median dose of misoprostol was 800 micrograms. A uterine rupture on a scarred uterus occurred. The rate of fetal autopsies in cases of malformations within 24 hours reached 96%.
  
  
  CONCLUSIONS
  This protocol allows a safe, rapid, cheap and painless late termination of pregnancy, when compared to other protocols.
authors.affiliation: Unité de Médecine Foetale, Fédération des Services de Gynécologie-Obstétrique, Hôpital Arnaud de Villeneuve, Montpellier.
authors.forename: M C
authors.initials: MC
authors.lastname: Hoffer
authors.forename: C
authors.initials: C
authors.lastname: Charlier
authors.forename: P L
authors.initials: PL
authors.lastname: Giacalone
authors.forename: L
authors.initials: L
authors.lastname: Zimbris
authors.forename: M
authors.initials: M
authors.lastname: Astruc
authors.forename: P
authors.initials: P
authors.lastname: Boulot
mesh_terms: D000019:Abortifacient Agents; D000028:Abortion, Induced / Q000009:adverse effects / Q000379:methods*; D000293:Adolescent; D000328:Adult; D015360:Analgesia, Epidural / Q000379:methods*; D002985:Clinical Protocols; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007795:Laminaria; D015735:Mifepristone; D016595:Misoprostol; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000019:Abortifacient Agents; D016595:Misoprostol; D015735:Mifepristone
vernacular_title: Evaluation de l'association RU 486-laminaires-misoprostol-anesthésie péridurale dans les interruptions médicales de grossesse des 2e et 3e trimestres.