[Molluscum contagiosum in immunosuppression with methotrexate: multiple warts with central depressions of the eyelids].
BACKGROUND
Poxvirus induced molluscum contagiosum is known to occur in children, elderly people and in patients with the acquired immune deficiency syndrome AIDS.


METHODS
We report on a 49-year-old patient who presented with a three-month history of multiple skin-coloured prominent warts on his right upper and lower eye-lid. On examination, the warts showed a central cavity and measured 2-6 mm in diameter. For his "mixed connective tissue disease" (MCTD) the patient took methotrexate in a weekly dosage of 7.5 mg since 3 years. Diagnosis of MCTD was made 7 years before. The warts were excised and studied histopathologically. One year postoperatively, there was no recurrence of the lesions.


CONCLUSIONS
Drug induced immunosuppression as with methotrexate may be associated with multiple periocular lesions due to molluscum contagiosum.
Cursiefen
C
C
Augenklinik mit Poliklinik der Friedrich-Alexander-Universität Erlangren-Nürnberg.
Holbach
L M
LM
D001706:Biopsy; D003937:Diagnosis, Differential; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000473:pathology; D005143:Eyelids / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000188:drug therapy* / Q000473:pathology; D008976:Molluscum Contagiosum / Q000139:chemically induced* / Q000473:pathology; D009894:Opportunistic Infections / Q000139:chemically induced* / Q000473:pathology
D007166:Immunosuppressive Agents; D008727:Methotrexate
Molluscum contagiosum bei Immunsuppression mit Methotrexat: Multiple Dellwarzen der Lider.