Mixed backbone oligonucleotides: improvement in oligonucleotide-induced toxicity in vivo.
Agrawal
S
S
Hybridon, Inc., Cambridge, MA 02139, USA.
Zhao
Q
Q
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics; D015195:Drug Design; D015316:Genetic Therapy; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000628:therapy; D016376:Oligonucleotides, Antisense / Q000737:chemistry* / Q000633:toxicity; D051381:Rats; D013329:Structure-Activity Relationship; D013873:Thionucleotides / Q000737:chemistry / Q000633:toxicity; D013921:Thrombocytopenia / Q000139:chemically induced
D000970:Antineoplastic Agents; D016376:Oligonucleotides, Antisense; D013873:Thionucleotides; D017868:Cyclic AMP-Dependent Protein Kinases