Synthesis of DHPA analogs and their inhibitory activities of human recombinant S-adenosyl-L-homocysteine hydrolase.
We report syntheses of DHPA analogs, e.g., 9-(3-formyl-2,3-dihydroxypropyl)adenine (FDHPA) and 9-(3-formyl-2,3-dihydroxypropyl)hypoxanthine (FDHPI). Among these DHPA analogs, FDHPA behaved as an irreversible inactivator of human recombinant SAH hydrolase.
Kitade
Y
Y
Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan.
Nakanishi
M
M
Hosoya
A
A
Hiraoka
A
A
Hayashi
M
M
Mori
K
K
Gotoh
T
T
Yatome
C
C
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006867:Hydrolases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008113:Liver Neoplasms; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; C016391:9-(2,3-dihydroxypropyl)adenine; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D000225:Adenine