Localization of leukemia inhibitory factor and interleukin-6 messenger ribonucleic acids in regenerating rat skeletal muscle.
In the present study, we characterized both temporal and spatial expression patterns of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) messenger ribonucleic acids (mRNAs) in injured skeletal muscle using in situ hybridization. LIF and IL-6 mRNAs were expressed in mononucleated cells and damaged muscle cells. Further, signals for LIF mRNA were also detected in Schwann cell-like cells of intramuscular nerves. These results suggest that the earliest events involved in the repair of injured muscles and nerves may be triggered by these cytokines.
Kami
K
K
Department of Health Science, Osaka University of Health and Sport Sciences, Japan.
Senba
E
E
D000818:Animals; D006131:Growth Inhibitors / Q000378:metabolism*; D017403:In Situ Hybridization; D015850:Interleukin-6 / Q000378:metabolism*; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000293:injuries / Q000378:metabolism* / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration; D013997:Time Factors
D006131:Growth Inhibitors; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D012333:RNA, Messenger