title: A case of chronic severe neutropenia: oral findings and consequences of short-term granulocyte colony-stimulating factor treatment.
abstract: Neutropenia is an absolute decrease in the number of circulating neutrophils in the blood which results in susceptibility to severe pyogenic infections. Various oral findings such as periodontitis, alveolar bone loss and ulceration may be seen in neutropenic patients. A case is presented of a 6 year old girl with chronic, probably congenital, severe neutropenia with frequent respiratory tract infections, recurrent oral ulcerations and significant periodontal break-down resembling prepubertal periodontitis. She was given granulocyte-colony stimulating factor (G-CSF) treatment which resulted in an increase in granulocyte count within two weeks and resolution of the neutropenic ulceration. It is suggested that G-CSF together with dental care regimens is a promising treatment model in chronic severe neutropenia cases presenting with oral manifestations.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, University of Hacettepe, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Hastürk
authors.forename: I
authors.initials: I
authors.lastname: Tezcan
authors.forename: L
authors.initials: L
authors.lastname: Yel
authors.forename: F
authors.initials: F
authors.lastname: Ersoy
authors.forename: O
authors.initials: O
authors.lastname: Sanal
authors.forename: N
authors.initials: N
authors.lastname: Yamalik
authors.forename: E
authors.initials: E
authors.lastname: Berker
mesh_terms: D010520:Aggressive Periodontitis / Q000188:drug therapy / Q000209:etiology*; D016301:Alveolar Bone Loss / Q000209:etiology; D002648:Child; D002908:Chronic Disease; D003773:Dental Plaque / Q000150:complications / Q000517:prevention & control; D003777:Dental Prophylaxis; D004198:Disease Susceptibility; D005260:Female; D005884:Gingival Hemorrhage / Q000209:etiology; D005891:Gingivitis / Q000209:etiology; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count; D009503:Neutropenia / Q000150:complications* / Q000151:congenital / Q000188:drug therapy; D009504:Neutrophils / Q000187:drug effects; D009910:Oral Hygiene; D019226:Oral Ulcer / Q000188:drug therapy / Q000209:etiology*; D010514:Periodontal Pocket / Q000209:etiology; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology
chemical_list: D016179:Granulocyte Colony-Stimulating Factor