title: Intercostal nerve nerve neuroma (PNS) implantation in spinal cord anastomosis bridging spinal cord transection--enhancement of central neurons (CNS) axonal regeneration.
abstract: The enhancement of axonal regeneration in the spinal cord transection is shown by implanting intercostal nerve neuroma with origin cephalic to spinal cord transection site. The nerve is implanted in the distal spinal cord near the transection site. The intercostal nerve peripheral portion is anchored in the distal spinal cord using a plasma clot suture. 2,3,4 Regeneration of (CNS) axons and (PNS) axons in the spinal cord transaction lesion demands care, rehabilitation, no infections, and maintenance of normal body functions. After a period of repair and rehabilitation "reflex" standing and walking developed in 26 mature female dogs. Surgical section of the implanted nerve resulted in loss of standing and reflex walking and return to a paraplegic condition. 2,3,4,5 Stimulation of the motor cortex and implanted intercostal nerve resulted in movements of the hind limbs of the standing and reflex walking dogs all having cord transection and intercostal nerve neuroma implantation. 2,3,4,5 The neuroma generates spontaneous electrical activity as unit discharges similar to seizure and epleptic activity. This activity has a role in spinal cord lesions in the induction of regeneration of axonal sprouting. 1,2,3,4,12,13,15
authors.affiliation: Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Turbes
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D004285:Dogs; D005260:Female; D007367:Intercostal Nerves / Q000637:transplantation*; D009416:Nerve Regeneration; D013116:Spinal Cord / Q000502:physiology* / Q000601:surgery