title: Increased expression of adhesion molecule CD18 (LFA-1beta) on the leukocytes of peripheral blood in patients with acute ischemic stroke.
abstract: OBJECTIVE
  The aim of this study was to investigate whether adhesion molecules play a role in acute ischemic stroke.
  
  
  METHODS
  Using immunofluorescence phenotyping and flow cytometry, the expression of leukocyte adhesion molecules CD54, CD11a, CD11b and CD18 in peripheral blood were measured within 12 h after onset of ischemia in 20 patients with stroke. Follow-up measurements were performed at 7 and 30 days after ictus.
  
  
  RESULTS
  CD18 immunofluorescence was significantly increased on the leukocytes within 12 h after onset in patients with stroke compared with the age-matched control group (20 patients with other neurological diseases). Follow-up measurement of CD18 revealed normal results as found in the control group.
  
  
  CONCLUSIONS
  Our data support the idea that adhesion molecules are involved in tissue injury in ischemic stroke.
authors.affiliation: Institute of Psychiatry and Neurology, Warsaw, Poland.
authors.forename: U
authors.initials: U
authors.lastname: Fiszer
authors.forename: G
authors.initials: G
authors.lastname: Korczak-Kowalska
authors.forename: W
authors.initials: W
authors.lastname: Palasik
authors.forename: J
authors.initials: J
authors.lastname: Korlak
authors.forename: A
authors.initials: A
authors.lastname: Górski
authors.forename: A
authors.initials: A
authors.lastname: Członkowska
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002545:Brain Ischemia / Q000097:blood* / Q000145:classification; D018845:CD11 Antigens / Q000032:analysis; D018821:CD18 Antigens / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D006098:Granulocytes / Q000737:chemistry; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D007958:Leukocyte Count; D007962:Leukocytes / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D018845:CD11 Antigens; D018821:CD18 Antigens; D018799:Intercellular Adhesion Molecule-1