Pharmacokinetics and pharmacodynamics of hydroxyurea.
Hydroxyurea is used in the treatment of various forms of cancer, sickle-cell anaemia and HIV infection. Oral absorption of the drug is virtually complete, the volume of distribution is equivalent to total body water and elimination is through both renal and nonrenal mechanisms. Nonrenal elimination of hydroxyurea is characterised by Michaelis-Menten kinetics. Further studies are necessary to clarify several aspects of the pharmacokinetics and pharmacodynamics of hydroxyurea: the effect of age and disease state, concentration-effect relationship, the role of therapeutic drug monitoring, and the mechanisms of renal and nonrenal elimination. The recent development of improved assays for hydroxyurea should have benefits for future pharmacokinetic studies.
Gwilt
P R
PR
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, USA.
Tracewell
W G
WG
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000755:Anemia, Sickle Cell / Q000188:drug therapy; D019380:Anti-HIV Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D000986:Antisickling Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D006918:Hydroxyurea / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019384:Nucleic Acid Synthesis Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D000986:Antisickling Agents; D019384:Nucleic Acid Synthesis Inhibitors; D006918:Hydroxyurea