Cytotoxic scalarane sesterterpenes from a sponge, Hyrtios erecta.
Novel scalarane sesterterpenes (1-4) were isolated from a sponge, Hyrtios erecta (order Dictyoceratida). They were characterized by means of spectral analyses, X-ray crystallography, and chemical reactions. Compound 1 showed potent in vitro and in vivo antitumor activities. In addition, the structure-activity relationship was also discussed using computer-assisted structure matching of 1 and aragusterols.
Tsuchiya
N
N
Biomedical Research Laboratories, Sankyo Co. Ltd., Tokyo, Japan.
Sato
A
A
Hata
T
T
Sato
N
N
Sasagawa
K
K
Kobayashi
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010936:Plant Extracts; D054830:Sesterterpenes; D013729:Terpenes