title: [The study of the morphology of ultramicrostructure in molecular level of nucleus herniation of lumbar intervertebral disc].
abstract: In order to investigate the morphology of ultramicrostructure in molecular level of nucleus herniations, the authors studied the ultramicrostructure of three cases of nucleus herniations of lumbar intervertebral disc which were proved by operations and one case of normal nucleus pulposus of fresh corpse by using of atomic force microscope. The results showed that the arrangement of collagen bundle, collagen fiber and procollagen fiber were different between the two conditions, and the morphology of molecular particles of proteoglycan in nucleus herniations was different from that in the normal condition. In the condition of nucleus herniations, the collagen fiber formed procollagen fiber reticular porous adhering to the molecules of protein and proteoglycan, and the DNA adhering to the monochain of RNA in fiberal cell nuclei, in the form of bichain and multichain three dimensions helix structures. The banded structure (64-78 mm) of the procollagen fiber, and the collagenation and calcification of the degenerated nuclens pulposuses, the quantity of which was significant greater than normal (P < 0.05) indicated that the chronic injury of lumbar intervertebral nucleus pulposuses gave rise to the injury and break of the collagen fiber which resulted in twist (tangle) phenomenon so that nucleus pulposuses lost their normal resistance strength.
authors.affiliation: First Affiliated Hospital of Naning Medical University.
authors.forename: T
authors.initials: T
authors.lastname: Zhu
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D003094:Collagen / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000648:ultrastructure*; D007405:Intervertebral Disc Displacement / Q000473:pathology*; D008159:Lumbar Vertebrae / Q000648:ultrastructure*; D008297:Male; D018625:Microscopy, Atomic Force; D008875:Middle Aged; D011347:Procollagen / Q000648:ultrastructure
chemical_list: D011347:Procollagen; D003094:Collagen