title: Late effects in survivors of bone tumors.
abstract: Today more than 71% of children with cancer are surviving their disease. This is because of improved treatment including aggressive combination therapy and better supportive care measures. The majority of patients with bone tumors are now being treated with surgery, chemotherapy, and radiation therapy, resulting in an increase in numbers of long-term survivors. This aggressive therapy, however, has increased the risk of developing late effects. This article reviews some of these late effects in survivors of bone tumors diagnosed in childhood or adolescence. Areas that are explored include cardiac, infections, second operations, second malignant neoplasms, renal, auditory, fertility, pulmonary, functional, and psychosocial outcomes. The need for long-term follow-up clinics is also addressed.
authors.affiliation: Department of Oncology-Hematology, Children's National Medical Center, Washington, DC 20010, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Mosher
authors.forename: B J
authors.initials: BJ
authors.lastname: McCarthy
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000150:complications / Q000628:therapy*; D006311:Hearing Disorders / Q000209:etiology; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D007239:Infections / Q000209:etiology; D007246:Infertility / Q000209:etiology; D007255:Information Services; D007674:Kidney Diseases / Q000209:etiology; D008171:Lung Diseases / Q000209:etiology; D016609:Neoplasms, Second Primary / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D017741:Survivors
chemical_list: D000970:Antineoplastic Agents