Correction of the anemia of epidermolysis bullosa with intravenous iron and erythropoietin.
Severe forms of epidermolysis bullosa result in a transfusion-dependent chronic anemia and are fatal. The cause of the anemia is unknown. We evaluated five children whose anemia failed to respond to oral iron but who became transfusion independent after treatment with intravenous iron and human recombinant erythropoietin.
Fridge
J L
JL
Department of Hematology/Oncology, Children's Hospital Oakland, California 94609, USA.
Vichinsky
E P
EP
D000293:Adolescent; D000753:Anemia, Refractory / Q000209:etiology* / Q000628:therapy*; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004820:Epidermolysis Bullosa / Q000150:complications*; D004921:Erythropoietin / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007501:Iron / Q000008:administration & dosage*; D000090463:Iron Deficiencies; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D004921:Erythropoietin; D007501:Iron