Regulation of G protein signalling in yeast.
A common property of cell signaling systems is the ability to adapt to chronic stimulation. A genetic analysis of receptor/G protein signaling in yeast has led to the identification of a new class of regulators of G protein signaling (RGS proteins), as well as to new insights about the regulatory role of G protein modifications (myristoylation, palmitoylation). Similar modes of regulation are now known to exist in humans. These discoveries fill some important gaps in our understanding of signal transduction, and provide an instructive example of how model organisms, like yeast, can provide new insights relevant to signal regulation in higher eukaryotes.
Dohlman
H G
HG
Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536-0812, USA.
Song
J
J
Apanovitch
D M
DM
DiBello
P R
PR
Gillen
K M
KM
D000818:Animals; D020558:GTP Phosphohydrolases / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D020690:GTPase-Activating Proteins; D006801:Humans; D011506:Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D015003:Yeasts / Q000502:physiology*; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins / Q000502:physiology
D020690:GTPase-Activating Proteins; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; D018631:ras Proteins