Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats.
Irradiated wounds are characterized by a slow healing process. Insulin-like growth factor-1 (IGF-1), a somatomedin C, has been shown in previous studies to stimulate collagen synthesis and bony repair. The purpose of this investigation is to evaluate the potential beneficial effects of recombinant IGF-1 in the healing of critical size calvarial defects in previously irradiated adult male Sprague-Dawley rats.
Thaller
S R
SR
Department of Surgery, University of Miami, FL 33101, USA.
Salzhauer
M A
MA
Rubinstein
A J
AJ
Thion
A
A
Tesluk
H
H
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects* / Q000528:radiation effects*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010025:Osteoradionecrosis / Q000188:drug therapy / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D012886:Skull / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D013997:Time Factors
D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I