Cortical anesthesia reduced the amplitude of local P300 event-related potential in rabbits by auditory oddball paradigm.
Eight rabbits were employed in this study. Under anesthesia, one electrode was fixed in the skull at the bregma and another was fixed, with three guide cannulas around it, at a parietal point 5 mm lateral to the bregma. Two weeks later, with a 10-day interval, either 0.5% lidocaine (9 microl) or the same volume of normal saline was injected into cortex through the cannulas. Event-related potentials (ERPs) evoked by auditory oddball paradigm were recorded before and after the injections in alert rabbits. The probability of occurrence for the 2 and 1 kHz stimulus tones was 90% (frequent) and 10% (rare), respectively. After lidocaine injection, P3 amplitude to rare stimuli decreased to 37.6% (P < 0.05), while N1 did not show any significant changes. ERPs from the bregma were intact. P3 and N1 did not change after normal saline injection. Our results show that local parietal cortex is one of the P3 generators.
Wang
Y
Y
Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan. wangyp@cenpok.net
Shiraishi
Y
Y
Kawai
Y
Y
Nakashima
K
K
D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects*; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D007276:Injections, Intraventricular; D008012:Lidocaine / Q000008:administration & dosage; D008845:Microinjections; D011817:Rabbits
D000779:Anesthetics, Local; D008012:Lidocaine