title: AIDS wasting syndrome as an enterometabolic disorder: the gut hypothesis.
abstract: There is an interesting relationship between the HIV virus, the health of the gastrointestinal tract, and AIDS wasting syndrome, involving Tumor Necrosis Factor alpha (TNF alpha), specific and non-specific immunity in the gut, gut permeability, and oxidative stress. It is hypothesized that the progression of HIV to full-blown AIDS may be impacted by maintaining a healthy gut. A therapeutic protocol which decreases oxidative stress, inhibits TNF alpha, enhances phase I and II liver detoxification, and improves specific and non-specific immunity in the gut should be part of a therapeutic protocol for HIV-infected individuals. Through a better understanding of the pathophysiology of HIV advancing to AIDS, the practitioner can develop a treatment strategy of nutritional and lifestyle changes which could theoretically prevent an HIV infection from advancing to full-blown AIDS.
authors.affiliation: FUHS/Chicago Medical School, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kaminski
authors.forename: S
authors.initials: S
authors.lastname: Weil
authors.forename: J
authors.initials: J
authors.lastname: Bland
authors.forename: P
authors.initials: P
authors.lastname: Jan
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D004064:Digestive System / Q000276:immunology* / Q000378:metabolism; D018450:Disease Progression; D015536:Down-Regulation; D015658:HIV Infections / Q000178:diet therapy* / Q000276:immunology / Q000503:physiopathology*; D019247:HIV Wasting Syndrome / Q000276:immunology / Q000378:metabolism; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha