[Mononuclear cells and specific proteins in the tissues of the fetoplacental complex during the physiological course of pregnancy and miscarriage].
Subsets of mononuclear cells, specific pregnancy proteins (SP-1, SP-3, PAPP-A) in the normal pregnancy decidua (NPD) and spontaneous abortion decidua (SAD), and trophoblast were studied. Significant decrease of lymphocytes infiltration was found in SAD. CD8+ cells rather than CD4+ cells predominated in NPD. CD4+ cells levels were lower in NPD in comparison with SAD. CD4+ lymphocytes rather than CD8+ cells predominated in SAD. Macrophages population was found to be increased in SAD in comparison with NPD. In blood vessels walls, cytoplasm of mononuclear cells and decidua stroma, PAPP-A and SP-3 were expressed in NPD and unexpressed or negative in SAD. In syncytiotrophoblast, SP-1 was expressed in normal pregnancy and unexpressed in spontaneous abortion. It is suggested that inadequate fetal-placental tissues counts of suppressor decidual lymphocytes, specific pregnancy proteins might be a cause of early spontaneous abortion.
Bondarenko
G I
GI
Chernyshov
V P
VP
Zadorozhnaia
T D
TD
D000022:Abortion, Spontaneous / Q000378:metabolism* / Q000473:pathology*; D002452:Cell Count; D003656:Decidua / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000166:cytology* / Q000378:metabolism*; D011247:Pregnancy / Q000378:metabolism*; D011257:Pregnancy Proteins / Q000378:metabolism*; D011261:Pregnancy Trimester, First; D014327:Trophoblasts / Q000166:cytology* / Q000378:metabolism*
D011257:Pregnancy Proteins
Mononuklearnye kletki i spetsificheskie belki v tkaniakh fetoplatsentarnogo kompleksa pri fiziologicheskom techenii beremennosti i nevynashivanii.