title: Progressive brain failure after diffuse hypoxic ischemic brain injury: a serial MR and proton MR spectroscopic study.
abstract: The findings at sequential MR imaging and proton MR spectroscopy of a patient with profound hypoxic-ischemic brain injury are reported. The pattern of structural and biochemical changes observed closely reflected the known evolution of postasphyxic brain degeneration. Particularly noteworthy were the sharp decrease of cortical N-acetylaspartate in the acute phase, suggesting the severity of the neuronal insult, and the subsequent progressive increase of choline, paralleling the delayed degeneration of white matter.
authors.affiliation: Department of Neuroradiology, Scientific Institute San Raffaele Hospital, University of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Falini
authors.forename: A J
authors.initials: AJ
authors.lastname: Barkovich
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: D
authors.initials: D
authors.lastname: Origgi
authors.forename: F
authors.initials: F
authors.lastname: Triulzi
authors.forename: G
authors.initials: G
authors.lastname: Scotti
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D001926:Brain Death / Q000175:diagnosis*; D002545:Brain Ischemia / Q000175:diagnosis*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D011247:Pregnancy; D013997:Time Factors