title: Acute and chronic phases of Toxoplasma gondii infection in mice modulate the host immune responses.
abstract: Murine antibody responses to soluble proteins are generally restricted to the immunoglobulin G1 (IgG1) isotype. When mice were infected with Toxoplasma gondii Beverley and concomitantly immunized with a soluble unrelated protein antigen, a modification in the isotypic distribution of antibodies directed against this nonparasite antigen was observed, with a preferential production of IgG2a. Interestingly, when mice were immunized with a soluble protein antigen during the chronic phase (day 40) of infection with T. gondii Beverley, a similar modification in the isotypic distribution of antiprotein antibodies was observed.
authors.affiliation: Microbiology Unit, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
authors.forename: T D
authors.initials: TD
authors.lastname: Nguyen
authors.forename: G
authors.initials: G
authors.lastname: Bigaignon
authors.forename: J
authors.initials: J
authors.lastname: Van Broeck
authors.forename: M
authors.initials: M
authors.lastname: Vercammen
authors.forename: T N
authors.initials: TN
authors.lastname: Nguyen
authors.forename: M
authors.initials: M
authors.lastname: Delmee
authors.forename: M
authors.initials: M
authors.lastname: Turneer
authors.forename: S F
authors.initials: SF
authors.lastname: Wolf
authors.forename: J P
authors.initials: JP
authors.lastname: Coutelier
mesh_terms: D000208:Acute Disease; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D002908:Chronic Disease; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D007132:Immunoglobulin Isotypes / Q000097:blood; D018664:Interleukin-12 / Q000276:immunology; D007781:Lactoferrin / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000032:analysis; D013154:Spleen / Q000276:immunology; D014124:Toxoplasmosis, Animal / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D016207:Cytokines; D007132:Immunoglobulin Isotypes; D012333:RNA, Messenger; D018664:Interleukin-12; D007781:Lactoferrin