Hydroxyakalone, a novel xanthine oxidase inhibitor produced by a marine bacterium, Agrobacterium aurantiacum.
A new xanthine oxidase inhibitor named hydroxyakalone was isolated from the culture broth of a marine bacterium Agrobacterium aurantiacum N-81106. Structure of hydroxyakalone was determined to be 4-amino-1H-pyrazolo[3,4-d]pyrimidine-3-one-6-ol by the spectral studies of hydroxyakalone and its permethyl derivative. The concentration to induce 50% inhibition (IC50) was 4.6 microM against xanthine oxidase.
Izumida
H
H
Marine Biotechnology Institute, Shimizu Laboratory, Shizuoka, Japan.
Adachi
K
K
Mihara
A
A
Yasuzawa
T
T
Sano
H
H
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D011720:Pyrazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012231:Rhizobium / Q000737:chemistry*; D014871:Water Microbiology; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors* / Q000187:drug effects
D004791:Enzyme Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; C111290:hydroxyakalone; D014969:Xanthine Oxidase