[Pefloxacin + metronidazole versus netilmicin + metronidazole in the prevention of nosocomial infections in contaminated surgery. Pefloxacin Study Group].
Pefloxacin plus metronidazole versus netilmicin plus metronidazole in the prevention of nosocomial infections during contaminated surgery. Surgical prophylaxis is widely used in contaminated surgery, especially colorectal surgery. In this clinical trial the efficacy of pefloxacin 800 mg i.v. slow infusion associated to metronidazole 500 mg i.v. 1-2 hours before surgery and then metronidazole alone after 6 and 12 hours versus netilmicin 200 mg i.m. associated to metronidazole 500 mg i.v. 1-2 hours before surgery and then both after 6 and 12 hours were evaluated in 97 patients suffering by colorectal surgery. Efficacy of prophylaxis in patients was evaluated in terms of appearance of post-surgical infections (abdominal, urinary, respiratory and wound infections). In pefloxacin + metronidazole group (53 patients), two cases of wound infections (3.8%) and three cases of respiratory infections (5.8%) were observed. In netilmicin + metronidazole group (44 patients), two cases of wound infections (4.9%), three cases of urinary infections (7%), three cases of respiratory infections (7.5%) and one case of intra-abdominal infection were observed. Our data confirmed that in colorectal surgery, the association pefloxacin, drug with microbiological and pharmacokinetics characteristics suitable for prophylaxis + metronidazole, active against anaerobes pathogens, prevents post-surgical infections as well as a reference association (netilmicin + metronidazole), with the advantage of a single administration.
Germiniani
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R
Istituto di Chirurgia Generale e Oncologia Chirurgica, Università degli Studi, Milano.
Montorsi
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W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage*; D003428:Cross Infection / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D007422:Intestines / Q000601:surgery*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D009428:Netilmicin / Q000008:administration & dosage*; D015366:Pefloxacin / Q000008:administration & dosage*; D011292:Premedication; D012141:Respiratory Tract Infections / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors; D014552:Urinary Tract Infections / Q000517:prevention & control
D000890:Anti-Infective Agents; D000892:Anti-Infective Agents, Urinary; D005839:Gentamicins; D008795:Metronidazole; D015366:Pefloxacin; D009428:Netilmicin
Pefloxacina + metronidazolo versus netilmicina + metronidazolo nella prevenzione delle infezioni nosocomiali in chirurgia contaminata. Gruppo Di Studio Pefloxacina.