title: Synthesis and in vitro anthelmintic activity against Nippostrongylus brasiliensis of new 2-amino-4-hydroxy-delta-valerolactam derivatives.
abstract: The synthesis of a series of 2-amino-4-hydroxy-delta-valerolactam derivatives is described (compounds 4 to 10). These compounds showed a high anthelmintic in vitro activity against the Nippostrongylus brasiliensis model.
authors.affiliation: Cátedra de Química Farmacéutica, Fac. de Química, Universidad de la República, Montevideo, Uruguay.
authors.forename: S
authors.initials: S
authors.lastname: Gordon
authors.forename: L
authors.initials: L
authors.lastname: Costa
authors.forename: M
authors.initials: M
authors.lastname: Incerti
authors.forename: E
authors.initials: E
authors.lastname: Manta
authors.forename: J
authors.initials: J
authors.lastname: Saldaña
authors.forename: L
authors.initials: L
authors.lastname: Domínguez
authors.forename: R
authors.initials: R
authors.lastname: Mariezcurrena
authors.forename: L
authors.initials: L
authors.lastname: Suescun
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D008297:Male; D008968:Molecular Conformation; D009559:Nippostrongylus / Q000187:drug effects* / Q000254:growth & development; D010881:Piperidones / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017206:Strongylida Infections / Q000188:drug therapy / Q000469:parasitology*; D013329:Structure-Activity Relationship
chemical_list: D000871:Anthelmintics; D010881:Piperidones; C043384:2-piperidone