title: Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia.
abstract: The neuroprotective effects of a novel Group II metabotropic glutamate receptor (mGluR) agonist, LY354740, have been evaluated in a gerbil model of global ischaemia. When administered at 50 mg/kg, i.p., 30 min and 6 h after a 3 min period of bilateral carotid artery occlusion (BCAO), the compound reduced the damage to CA1 hippocampal neurones to a significant level. However, when the ischaemic insult was made more severe, by increasing the period of occlusion to 4 and 5 min, the neuroprotective effects of LY354740 were reduced. From these findings, it would appear that Group II mGluRs may play a role in ischaemic damage in the gerbil hippocampus and that agonists at these receptors are potential neuroprotective agents.
authors.affiliation: Lilly Research Centre, Eli Lilly & Co, Windlesham, Surrey, UK.
authors.forename: A
authors.initials: A
authors.lastname: Bond
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Neill
authors.forename: C A
authors.initials: CA
authors.lastname: Hicks
authors.forename: J A
authors.initials: JA
authors.lastname: Monn
authors.forename: D
authors.initials: D
authors.lastname: Lodge
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D004195:Disease Models, Animal; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D005849:Gerbillinae; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*
chemical_list: D001643:Bridged Bicyclo Compounds; D018690:Excitatory Amino Acid Agonists; D018696:Neuroprotective Agents; D018094:Receptors, Metabotropic Glutamate; C104753:eglumetad