title: Intestinal absorption and enterohepatic circulation of folic acid: effect of ethanol.
abstract: This study sought to determine the intestinal in vivo absorption of folic acid by the whole intestine, and the appearance of this compound in bile in control and ethanol-fed rats. Intestinal folic acid absorption in rats with the bile duct cannulated decreased in ethanol-fed rats with respect to control rats. This difference was significant at 1 and 2.5 microM concentrations of folic acid. This result is in contrast with previous work in our laboratory on rats with intact bile ducts, where ethanol-fed rats had an increase in folic acid absorption. The results obtained in the present work suggest an impaired enterohepatic recycling of folic acid in ethanol-fed rats.
authors.affiliation: Departamento de Fisiología y Biología Animal, Facultad de Farmacia, Universidad de Sevilla, España.
authors.forename: O
authors.initials: O
authors.lastname: Fernández
authors.forename: O
authors.initials: O
authors.lastname: Carreras
authors.forename: M L
authors.initials: ML
authors.lastname: Murillo
mesh_terms: D000821:Animal Feed; D000818:Animals; D001646:Bile / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D002492:Central Nervous System Depressants / Q000008:administration & dosage; D004764:Enterohepatic Circulation / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage; D005492:Folic Acid / Q000187:drug effects / Q000378:metabolism / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol; D005492:Folic Acid