Lipoproteins in patients with isolated hyperuricemia.
BACKGROUND
There have been described abnormalities in the lipoprotein profile of hyperuricemic patients, it has not been clarified wether these abnormalities are due to the hyperuricemia or to the dyslipema often associated to these patients. Our aim is to study the apolipoprotein profile in hyperuricemic patients without dyslipemia compared to a control population.


METHODS
30 hyperuricemic patients and 26 healthy controls. Measurements were of blood uric acid, total cholesterol, total triglycerides, creatinine, HDL-C, and VLDL cholesterol, triglyceride, Apo B, Apo CII and Apo CIII (1 and 2). Uric acid clearance and fractionated excretion were measured in 24 h. urine samples.


RESULTS
No significant differences were found between hyperuricemic and control patients in cholesterol, triglycerides and apo B in VLDL, or LDL and HDL cholesterol. The levels of apo B, Apo AI levels and apo CIII/apo CII were similar in the hyperuricaemic and controls.


CONCLUSIONS
There are two types of hyperuricaemic patients, one group associated to hyperlipideamia and would be included in the X Syndrome. The other group not associated to other metabolic abnormalities. Is important to distinguish between these two groups to define the prognosis of a given patient because the greater cardiovascular risk linked hyperuricaemic patients could be related to the association to others cardiovascular risks factors.
Tinahones
F J
FJ
Section of Endocrinology, Regional Hospital of Málaga, Spain.
Vazquez
F
F
Soriguer
F J
FJ
Collantes
E
E
D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*
D001053:Apolipoproteins; D008074:Lipoproteins; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol