Pathological changes in rats hepatocytes on acute lindane poisoning.
Histological, histochemical and ultrastructural examinations of the liver were carried out on rats. The animals were given crystalline lindane intragastrically, in a dose evoking acute intoxication, (1/3 LD50). Then the rats were decapited after 1, 3, 10, 20 and 36 days following pesticide administration. The obtained results indicate, that acute lindane intoxication produces morphological changes in the rat liver, which evidence a disturbance inenergetic processes of hepatocytes and they are reversible and adaptative.
Sulik
M
M
Department of Pathological Anatomy, Medical Academy of Białystok.
Kemona
A
A
Szynaka
B
B
Sulik
A
A
Sulkowska
M
M
Kisielewski
W
W
D000208:Acute Disease; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D005500:Follow-Up Studies; D006003:Glycogen / Q000032:analysis; D001556:Hexachlorocyclohexane / Q000506:poisoning*; D006651:Histocytochemistry; D007306:Insecticides / Q000506:poisoning*; D007928:Lethal Dose 50; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D015388:Organelles / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar
D007306:Insecticides; D008055:Lipids; D001556:Hexachlorocyclohexane; D006003:Glycogen