title: Clozapine-induced agranulocytosis: a case report. Immunopathophysiological considerations.
abstract: A 46-year-old woman is described with a clozapine-induced agranulocytosis. She was treated with a broad-spectrum antibiotic and supportive care was provided with granulocyte colony-stimulating factor (G-CSF). Immune-mediated mechanisms of clozapine-induced agranulocytosis and the role of haematopoietic growth factors are discussed.
authors.affiliation: Department of Internal Medicine, State University Hospital Groningen, Netherlands. a.a.vandeLoosdrecht@int.azg.nl
authors.forename: A A
authors.initials: AA
authors.lastname: van de Loosdrecht
authors.forename: H J
authors.initials: HJ
authors.lastname: Faber
authors.forename: P
authors.initials: P
authors.lastname: Hordijk
authors.forename: D R
authors.initials: DR
authors.lastname: Uges
authors.forename: A
authors.initials: A
authors.lastname: Smit
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015377:Cilastatin / Q000627:therapeutic use; D000077728:Cilastatin, Imipenem Drug Combination; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D018572:Disease-Free Survival; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D007958:Leukocyte Count; D008875:Middle Aged; D009426:Netherlands; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D004338:Drug Combinations; D015377:Cilastatin; D016179:Granulocyte Colony-Stimulating Factor; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination; D003024:Clozapine