[The characteristics of the action of immunodepressive preparations on the killer activity of the blood leukocytes in patients with multiple myeloma].
Overall twenty patients with multiple myeloma (MM) were studied during the advanced stage of the disease before the initiation of the cytostatic therapy. The results obtained suggest that cytostatic drugs and prednizolon have suppressive action on blood leucocyte killer activity. Following in vitro vincristin exposure of MM patients' leucocytes cytolytic activity of blood leucocyte lymphoid population appeared to be suppressed whereas incubation of leucocytes with the solution of cyclophosphane leads to preponderant decrease in the killer function of neutrophils. In vitro prednizolon exposure of MM patients' leucocytes results in suppression of activity of the antibody-dependent cellular cytotoxicity.
Vozniuk
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VP
D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects / Q000276:immunology; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents
Osobennosti deĭstviia immunodepressivnykh preparatov na killernuiu aktivnost' leĭkotsitov krovi bol'nykh mielomnoĭ bolezn'iu.