Synthesis of novel dioxane nucleosides having two bases, physico-chemical properties, and their biological activities.
Novel dioxane nucleosides having two bases, 2(R)-(5-fluorouracil-1-yl)-5(R)-hydroxymethyl-3(R)-(uracil-1-yl)-1,4-dioxane (7a) and 2(S)-(5-fluorouracil-1-yl)-5(R)-hydroxymethyl-3(R)-(uracil-1-yl)-1,4-dioxane (7b) were synthesized from uridine to develop a new category of nucleoside for therapeutic use. Some derivative of precursors of the nucleoside were also synthesized and several compounds synthesized were tested antitumor activity using human gastric cancer cell lines in culture.
Kajimoto
N
N
National Cancer Center Research Institute, Tokyo, Japan.
Yamaizumi
J
J
Aida
M
M
Harada
K
K
Maeda
M
M
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D004146:Dioxanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D007202:Indicators and Reagents; D015394:Molecular Structure; D013274:Stomach Neoplasms; D014407:Tumor Cells, Cultured; D014529:Uridine
C113074:2-(5-fluorouracil-1-yl)-5-hydroxymethyl-3-(uracil-1-yl)-1,4-dioxane; D000964:Antimetabolites, Antineoplastic; D004146:Dioxanes; D007202:Indicators and Reagents; D005472:Fluorouracil; D014529:Uridine