Limited allelic polymorphism in the human interleukin-3 gene.
Interleukin-3 (IL-3) is a cytokine expressed primarily in activated T cells mast cells and natural killer (NK) cells. Interleukin-3 has the capability to stimulate the proliferation and differentiation of multipotential stem cells and has a role in shaping the immune response. In order to better understand the biological role of IL-3, a study of polymorphisms within the human IL-3 gene and its upstream regulatory elements has been conducted. Using a modification of the bidirectional dideoxy fingerprinting method, a group of 88 Caucasoid individuals were screened for polymorphism in the IL-3 enhancer, promoter and gene coding regions. Analysis revealed the presence of several infrequent polymorphisms which may affect IL-3 functionality.
Jeong
M C
MC
Department of Neurology, School of Medicine, University of California, San Francisco, CA 94143-0435, USA.
Navani
A
A
Oksenberg
J R
JR
D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D004742:Enhancer Elements, Genetic; D005091:Exons; D006801:Humans; D007377:Interleukin-3 / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013601:T-Lymphocytes / Q000276:immunology
D017931:DNA Primers; D007377:Interleukin-3