Delayed cellulitis associated with conservative therapy for breast cancer.
OBJECTIVE
Delayed breast cellulitis is an infrequently reported entity after conservation therapy for breast cancer. We describe our experience with this entity at Naval Medical Center, San Diego.


METHODS
Eight patients who presented with delayed cellulitis after wide local excision/axillary dissection and breast radiotherapy (RT) are presented. Their clinical characteristics and therapy are described and possible causative factors are analyzed.


RESULTS
The latency of breast cellulitis is variable after breast conservation therapy, although most cases in our experience and in the literature occur within a year post-RT. These infections are frequently refractory to a single course of antibiotics (n = 4 cases in our experience). Some patients suffer multiple episodes separated by months.


CONCLUSIONS
Breast cancer patients are at risk for delayed cellulitis after conservative surgery and RT. The mechanism of such events probably involves lymph stasis, however, therapy is no different from the more frequently occurring cases of cellulitis presenting perioperatively.
Miller
S R
SR
Breast Health Center, Naval Medical Center, San Diego, California 92134-5000, USA.
Mondry
T
T
Reed
J S
JS
Findley
A
A
Johnstone
P A
PA
D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage; D017963:Azithromycin / Q000627:therapeutic use; D001941:Breast Diseases / Q000188:drug therapy / Q000209:etiology*; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D002481:Cellulitis / Q000188:drug therapy / Q000209:etiology*; D019818:Clavulanic Acid / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004009:Dicloxacillin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D015412:Mastectomy, Segmental; D008875:Middle Aged; D011183:Postoperative Complications; D011879:Radiotherapy Dosage
D019818:Clavulanic Acid; D000658:Amoxicillin; D017963:Azithromycin; D004009:Dicloxacillin