title: [Lupus nephropathy treated with cyclosporine A. Report of 3 cases].
abstract: Three patients are reported who had systemic lupus erythematosus and membrane-proliferative glomerulonephritis. These patients failed to respond to intravenous cyclophosphamide and steroids and were then changed to receive oral cyclosporine A, at a dose of 5 mg/kg/day. The three patients showed remission of disease, symptoms, and renal and immunological parameters, with minimal secondary effects. The medical literature was reviewed and cyclosporine A is suggested to be a therapeutical choice for patients with lupus nephropathy even when they do not respond to other immunosuppressive regimes, such as pulse cyclophosphamide.
authors.affiliation: Servicio de Medicina Interna I, Clínica Puerta de Hierro, Madrid.
authors.forename: M
authors.initials: M
authors.lastname: García Gasalla
authors.forename: M
authors.initials: M
authors.lastname: Yebra Bango
authors.forename: J A
authors.initials: JA
authors.lastname: Vargas Núñez
authors.forename: E
authors.initials: E
authors.lastname: López García
authors.forename: M
authors.initials: M
authors.lastname: Villarreal García-Lomas
authors.forename: A
authors.initials: A
authors.lastname: Durántez Martínez
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine
vernacular_title: Nefropatía lúpica tratada con ciclosporina A. A propósito de tres casos.