title: Fast imaging of phosphocreatine using a RARE pulse sequence.
abstract: A technique is described for acquiring phosphocreatine (PCr) images of skeletal muscle using a rapid acquisition with relaxation enhancement (RARE) pulse sequence. All of the phosphorus metabolites other than PCr are forced to dephase within the first few echoes, whereas the Carr-Purcell Meiboom-Gill (CPMG) pulse sequence maintains a high PCr signal long enough to acquire 64 echoes in a single shot. Axial PCr images of a human forearm with a signal-to-noise ratio of 9 were acquired in 2 min. The effect of the refocusing pulse section profile on the ratio of desired to undesired metabolite signal is demonstrated.
authors.affiliation: Department of Radiology, University of Pennsylvania Medical Center, Philadelphia 19104-2649, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Greenman
authors.forename: M A
authors.initials: MA
authors.lastname: Elliott
authors.forename: K
authors.initials: K
authors.lastname: Vandenborne
authors.forename: M D
authors.initials: MD
authors.lastname: Schnall
authors.forename: R E
authors.initials: RE
authors.lastname: Lenkinski
mesh_terms: D005542:Forearm; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D018482:Muscle, Skeletal / Q000378:metabolism*; D019047:Phantoms, Imaging; D010725:Phosphocreatine / Q000378:metabolism*; D013997:Time Factors
chemical_list: D010725:Phosphocreatine