title: [Sublingual isosorbide-5 mononitrate during coronary arteriography. Comparison with sublingual nitroglycerin].
abstract: OBJECTIVE
  To evaluate the effect of sublingual isosorbide-5 mononitrate (ISMN) and nitroglycerin (NTG) on luminal diameter of epicardial coronary arteries, mean arterial pressure and deleterious effects.
  
  
  METHODS
  Fifty patients were submitted to cardiac catheterization and coronary arteriography, at baseline, and 5 min after sublingual administration of ISMN, group A (GA) or NTG, group B (GB).
  
  
  RESULTS
  Reference vessel diameter increased in both groups, without statistical significance. In GA and GB, a decrease (1.66 mmHg) and an increase (0.79 mmHg) in mean arterial pressure, respectively, were demonstrated (p = 0.123). There were no deleterious effects with the use of these drugs.
  
  
  CONCLUSIONS
  Sublingual ISMN is an alternative to administration of NTG during coronary arteriography, and represents a therapeutic alternative to ischemic heart disease treatment.
authors.affiliation: Instituto do Coração do Hospital das Clínicas, FMUSP.
authors.forename: A E
authors.initials: AE
authors.lastname: Moreira
authors.forename: S
authors.initials: S
authors.lastname: Arie
authors.forename: E L
authors.initials: EL
authors.lastname: Costa
authors.forename: L F
authors.initials: LF
authors.lastname: Campos
authors.forename: P R
authors.initials: PR
authors.lastname: Soares
authors.forename: D P
authors.initials: DP
authors.lastname: Garcia
mesh_terms: D000286:Administration, Sublingual; D001794:Blood Pressure / Q000187:drug effects*; D006328:Cardiac Catheterization; D002932:Cineangiography / Q000379:methods*; D003331:Coronary Vessels / Q000187:drug effects*; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate
vernacular_title: Ação do mononitrato-5 de isossorbida sublingual durante cinecoronariografia. Comparação com o uso de nitroglicerina sublingual.