title: Optical recording of responses to frequency-modulated sounds in the auditory cortex.
abstract: Using an optical recording method with a voltage-sensitive dye, we recorded activities in the primary auditory cortex (AI) of anesthetized guinea pigs in response to frequency-modulated (FM) sounds and sounds with stepwise changes in frequency (SF). Responses to the FM sound showed a spatiotemporal pattern in which a localized active spot traversed the isofrequency bands in the AI, and they differed from the band-like responses to the SF sound. These results indicate that time-varying sounds are represented as spatiotemporal activation of tonotopic organization in the AI by spectral cues with interactions between frequency bands.
authors.affiliation: Department of Neurophysiology, Medical Research Institute, Tokyo Medical and Dental University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Horikawa
authors.forename: M
authors.initials: M
authors.lastname: Nasu
authors.forename: I
authors.initials: I
authors.lastname: Taniguchi
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D004594:Electrophysiology; D005456:Fluorescent Dyes; D006168:Guinea Pigs
chemical_list: D005456:Fluorescent Dyes