title: [Heparin cofactor II and thrombophilic conditions].
abstract: Heparin co-factor II is in addition to antithrombin III another heparin dependent thrombin inhibitor. This glycoprotein blocks thrombin action not only in haemostasis but also in its other effects. Congenital deficiency of heparin co-factor II was found equally frequently among asymptomatic subjects and patients with thrombotic complications. Although its deficiency probably is not a serious risk factor of thromboembolic disease, it can promote its development in a significant way. The authors describe the case of a child with thrombotic complications and a congenital deficiency of heparin co-factor II.
authors.affiliation: Klinika hematológie a transfuziológie MFN a JLF UK.
authors.forename: J
authors.initials: J
authors.lastname: Hudecek
authors.forename: E
authors.initials: E
authors.lastname: Hal'áková
authors.forename: J
authors.initials: J
authors.lastname: Ivanková
authors.forename: P
authors.initials: P
authors.lastname: Kubisz
mesh_terms: D002675:Child, Preschool; D005260:Female; D015844:Heparin Cofactor II / Q000172:deficiency*; D006801:Humans; D019851:Thrombophilia / Q000097:blood / Q000209:etiology*
chemical_list: D015844:Heparin Cofactor II
vernacular_title: Heparinový kofaktor II a trombofilní stavy.