Metoclopramide and nitrendipine are unable to enhance cytotoxicity of mitoxantrone in sensitive and resistant murine leukemias in vivo.
The influence of metoclopramide and nitrendipine on the antitumor action of mitoxantrone (MX) in murine leukemias L1210 and P388 was investigated. These agents were administered in combination with MX to mice bearing sensitive or resistant leukemias. Mitoxantrone resistant P388 was developed in vivo by repeated passages of the tumor to animals treated with suboptimal dose of the drug. Survival time of mice receiving combined therapy were not prolonged as compared with animals treated with MX alone. Both metoclopramide and nitrendipine were unable to overcome MX resistance even partially.
Potemski
P
P
Department of Pharmacology, University Medical School, Lódź, Poland.
Polakowski
P
P
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D007941:Leukemia P388 / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D008942:Mitoxantrone / Q000008:administration & dosage / Q000494:pharmacology; D009368:Neoplasm Transplantation; D014411:Neoplastic Stem Cells / Q000187:drug effects; D009568:Nitrendipine / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity
D002121:Calcium Channel Blockers; D009568:Nitrendipine; D008942:Mitoxantrone; D008787:Metoclopramide