title: DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.
abstract: This review summarizes reports of recurrent DNA sequence copy number amplifications in human neoplasms detected by comparative genomic hybridization. Some of the chromosomal areas with recurrent DNA copy number amplifications (amplicons) of 1p22-p31, 1p32-p36, 1q, 2p13-p16, 2p23-p25, 2q31-q33, 3q, 5p, 6p12-pter, 7p12-p13, 7q11.2, 7q21-q22, 8p11-p12, 8q, 11q13-q14, 12p, 12q13-q21, 13q14, 13q22-qter, 14q13-q21, 15q24-qter, 17p11.2-p12, 17q12-q21, 17q22-qter, 18q, 19p13.2-pter, 19cen-q13.3, 20p11.2-p12, 20q, Xp11.2-p21, and Xp11-q13 and genes therein are presented in more detail. The paper with more than 150 references and two tables can be accessed from our web site http://www.helsinki.fi/lglvwww/CMG.html. The data will be updated biannually until the year 2001.
authors.affiliation: Laboratory of Medical Genetics, Helsinki University Central Hospital, Finland. sakari.knuutila@helsinki.fi
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
authors.forename: A M
authors.initials: AM
authors.lastname: Björkqvist
authors.forename: K
authors.initials: K
authors.lastname: Autio
authors.forename: M
authors.initials: M
authors.lastname: Tarkkanen
authors.forename: M
authors.initials: M
authors.lastname: Wolf
authors.forename: O
authors.initials: O
authors.lastname: Monni
authors.forename: J
authors.initials: J
authors.lastname: Szymanska
authors.forename: M L
authors.initials: ML
authors.lastname: Larramendy
authors.forename: J
authors.initials: J
authors.lastname: Tapper
authors.forename: H
authors.initials: H
authors.lastname: Pere
authors.forename: W
authors.initials: W
authors.lastname: El-Rifai
authors.forename: S
authors.initials: S
authors.lastname: Hemmer
authors.forename: V M
authors.initials: VM
authors.lastname: Wasenius
authors.forename: V
authors.initials: V
authors.lastname: Vidgren
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D002869:Chromosome Aberrations; D002874:Chromosome Mapping / Q000379:methods; D002877:Chromosomes, Human / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D018628:Gene Dosage; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D009693:Nucleic Acid Hybridization
chemical_list: D004273:DNA, Neoplasm