[The effect of salben on the rheological properties of the bronchial secretion].
OBJECTIVE
Assessment of the effect of a new Russian selective sympathomimetic salben (powder for inhalations) on bronchial secretion viscosity and adhesion.


METHODS
Salben or placebo (sodium bensoate) were given to 82 and 30 patients (control) with bronchial asthma, respectively. The response was assessed by clinical, laboratory and instrumental findings.


RESULTS
A statistically significant (p < 0.05) reduction of the viscosity and adhesion (by 15 and 20%, respectively) was noted in the salben group which also demonstrated improved external respiration.


CONCLUSIONS
Salben induced positive effect on bronchial secretion viscosity and adhesion.
Marinin
V F
VF
Kakhnovskiĭ
I M
IM
Sorokina
L A
LA
Smirnova
Z V
ZV
Arkhipova
S V
SV
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D000420:Albuterol / Q000008:administration & dosage / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D001565:Benzoates / Q000008:administration & dosage / Q000494:pharmacology; D019817:Benzoic Acid; D001980:Bronchi / Q000187:drug effects* / Q000378:metabolism*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D005100:Expectorants / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011208:Powders; D013183:Sputum / Q000187:drug effects / Q000378:metabolism; D013566:Sympathomimetics / Q000008:administration & dosage / Q000494:pharmacology*; D014783:Viscosity / Q000187:drug effects
D001565:Benzoates; D001993:Bronchodilator Agents; D004338:Drug Combinations; D005100:Expectorants; D011208:Powders; D013566:Sympathomimetics; D019817:Benzoic Acid; D000420:Albuterol
Vliianie sal'bena na reologicheskie svoĭstva bronkhial'nogo sekreta.