Continuous administration of insulin-like growth factor-I and basic fibroblast growth factor does not affect left ventricular geometry after acute myocardial infarction in rats.
We examined the long-term effect of exogenous administration of bFGF and IGF-I on myocardial geometry in 72 Sprague-Dawley male rats subjected to AMI. A preloaded miniature osmotic pump subsequently implanted in the peritoneum for continuous infusion (1 week) of IGF-I, bFGF, IGF-I+bFGF or rat albumin. Six weeks following AMI the rats were killed and cross-section slices were analyzed for left ventricular geometry. No differences were observed between IGF-I-treated, bFGF-treated, IGF-I+bFGF-treated and control groups in all parameters of the left ventricle.
Scheinowitz
M
M
The Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel-Hashomer, Israel. mickeys@post.tau.ac.il
Abramov
D
D
Kotlyar
A
A
Savion
N
N
Eldar
M
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005069:Evaluation Studies as Topic; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006352:Heart Ventricles / Q000473:pathology; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D016222:Fibroblast Growth Factor 2; D007334:Insulin-Like Growth Factor I