title: The usefulness of combined high-frequency percussive ventilation during acute respiratory failure after smoke inhalation.
abstract: Inhalation injury and bacterial pneumonia represent some of the most important causes of mortality in burn patients. We describe 11 severely burned patients with acute respiratory failure due to inhalation injury who did not respond adequately to conventional respiratory support. High-frequency percussive ventilation (HFPV) is a recent ventilatory mode, which combines the advantages of conventional ventilation with some of those of high-frequency ventilation. Seven patients developed pulmonary infection during the acute phase; one patient died of multiple organ failure on day 25. All the other patients survived; two developed bronchiolitis obliterans symptoms before discharge. No side-effects were noted and haemodynamic tolerance of HFPV was excellent. Our findings suggest that HFPV can improve pulmonary function and gas exchange in these catastrophic pulmonary failures following inhalation injury.
authors.affiliation: Burn Center Brussels, Queen Astrid Military Hospital, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Reper
authors.forename: R
authors.initials: R
authors.lastname: Dankaert
authors.forename: F
authors.initials: F
authors.lastname: van Hille
authors.forename: P
authors.initials: P
authors.lastname: van Laeke
authors.forename: L
authors.initials: L
authors.lastname: Duinslaeger
authors.forename: A
authors.initials: A
authors.lastname: Vanderkelen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001989:Bronchiolitis Obliterans / Q000209:etiology; D002056:Burns / Q000150:complications; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006611:High-Frequency Jet Ventilation; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D010100:Oxygen / Q000097:blood; D018410:Pneumonia, Bacterial / Q000209:etiology; D011175:Positive-Pressure Respiration; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D015208:Smoke Inhalation Injury / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D015996:Survival Rate
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen