Immunocytochemical localization of aquaporin 1 in the rat retina.
Aquaporins transport water through membranes of various tissues, thereby playing crucial roles in a number of physiological processes. Aquaporin 1 (AQP1, also known as CHIP, channel forming integral membrane protein of 28 kDa) is the first identified protein to function as a water channel and has been recently shown to be present in the rat retina. This study was conducted to examine the cellular localization of AQP1 in the rat retina by immunocytochemistry using antisera against AQP1. The AQP1-like immunoreactivity was present in a certain population of amacrine cells and in the proximal processes of Müller cells. Thus, AQP1 appears to be important in the retinal homeostasis.
Kim
I B
IB
Department of Anatomy, Catholic University Medical College, Seoul, South Korea.
Oh
S J
SJ
Nielsen
S
S
Chun
M H
MH
D000818:Animals; D051398:Aquaporin 1; D020346:Aquaporins; D015353:Eye Enucleation; D007150:Immunohistochemistry; D007473:Ion Channels / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000737:chemistry* / Q000166:cytology; D013194:Staining and Labeling
C496022:Aqp1 protein, rat; D020346:Aquaporins; D007473:Ion Channels; D051398:Aquaporin 1