[Prognostic significance of loss of heterozygosity in breast cancer].
Loss of heterozygosity (LOH) was analyzed in 113 cases of sporadic breast cancer using 35 microsatellite markers on 20 chromosomes. LOH was frequently seen in 17p (44%), 16q (31%), 17q (29%) and 13q (23%). Individual patients were scored according to the incidence of LOH at the above four chromosomal markers; with no LOH as 1, with one or two LOH as 2, and with three of four LOH as 3. A high LOH score was well associated with high histological grade (p = 0.019) and a significantly poor prognosis (p = 0.0035). These data suggest that accumulation of LOH occurs at a later stage of breast cancer progression, and that the LOH score may be a useful prognostic marker of breast cancer.
Iwase
H
H
Second Dept. of Surgery, Nagoya City University Medical School.
Iwata
H
H
Toyama
T
T
Hara
Y
Y
Omoto
Y
Y
Kobayashi
S
S
D001943:Breast Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002882:Chromosomes, Human, Pair 13; D002885:Chromosomes, Human, Pair 16; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D008207:Lymphatic Metastasis; D018895:Microsatellite Repeats; D015999:Multivariate Analysis; D011379:Prognosis; D015996:Survival Rate