title: Endovascular coil embolization of microsurgically produced experimental bifurcation aneurysms in rabbits.
abstract: BACKGROUND
  Endovascular treatment of cerebral aneurysms is a relatively new method, since only a few animal models and data are available. The present experimental study was performed in order to establish an appropriate aneurysm animal model, to determine the rate of permanent occlusion, and to correlate radiologic and morphologic findings.
  
  
  METHODS
  End-to-side anastomoses of both common carotid arteries were performed microsurgically in 53 chinchilla rabbits. Venous pouches were adapted into the newly created bifurcation, resulting in berry-shaped aneurysms comparable to those in humans with regard to size and hemodynamics. Platinum and tungsten coils were used for endovascular embolization. The embolized aneurysms were investigated radiologically and morphologically.
  
  
  RESULTS
  Twenty-three carotid bifurcation aneurysms remained for testing endovascular therapeutic approaches. The morphologic examinations of 13 embolized aneurysms revealed in no instance a complete obliteration, even in the three cases that were considered completely embolized according to angiographic criteria.
  
  
  CONCLUSIONS
  The present animal model is an optimal tool for endovascular research. Analysis of the results of coil obliteration revealed a considerable discrepancy between radiologic and pathologic findings. The radiologic degree of aneurysm occlusion was overestimated.
authors.affiliation: Department of Neurosurgery, Technical University RWTH Aachen, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Spetzger
authors.forename: J
authors.initials: J
authors.lastname: Reul
authors.forename: J
authors.initials: J
authors.lastname: Weis
authors.forename: H
authors.initials: H
authors.lastname: Bertalanffy
authors.forename: J M
authors.initials: JM
authors.lastname: Gilsbach
mesh_terms: D000818:Animals; D002340:Carotid Artery Diseases / Q000628:therapy*; D002682:Chinchilla; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D002532:Intracranial Aneurysm / Q000628:therapy*; D011817:Rabbits; D014656:Vascular Surgical Procedures / Q000379:methods