Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil.
Peters
G J
GJ
Department of Oncology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
van Groeningen
C J
CJ
Pinedo
H M
HM
D000818:Animals; D001682:Biological Availability; D001711:Biotransformation; D003110:Colonic Neoplasms / Q000201:enzymology*; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil / Q000493:pharmacokinetics*; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D051379:Mice; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity; D013936:Thymidine / Q000494:pharmacology; D013941:Thymine / Q000494:pharmacology; D014498:Uracil / Q000494:pharmacology
D014498:Uracil; D010088:Oxidoreductases; D042943:Dihydrouracil Dehydrogenase (NADP); D013941:Thymine; D005472:Fluorouracil; D013936:Thymidine