Severe heat stroke associated with high plasma levels of plasminogen activator inhibitor 1.
In a 38-year-old man, severe heat stroke caused disseminated intravascular coagulation (DIC) associated with significantly elevated plasma plasminogen activator inhibitor 1 levels. Investigation of the effects of hyperthermia on coagulation and fibrinolysis showed, in apparent conflict with previous reports, a time lag between the initial hypercoagulable and hyperfibrinolytic response (within 24 hr) and hypofibrinolysis shown by a disproportionate increase of PAI-1 (after 24 h), which possibly occurs in correspondence with the recovery of vascular endothelial integrity. The patient was discharged without sequelae although computed tomography (CT) scans indicated the likelihood of venous infarction or posterior inferior cerebellar artery area infarction secondary to DIC.
Aoki
K
K
Department of Emergency Medicine, Hamamatsu University School of Medicine, Japan.
Yoshino
A
A
Ueda
Y
Y
Urano
T
T
Takada
A
A
D000328:Adult; D001777:Blood Coagulation / Q000502:physiology; D002531:Cerebellum / Q000098:blood supply / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000097:blood / Q000209:etiology; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology; D004730:Endothelium, Vascular / Q000473:pathology / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology; D005500:Follow-Up Studies; D018883:Heat Stroke / Q000097:blood* / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D015842:Serine Proteinase Inhibitors / Q000097:blood*; D013921:Thrombocytopenia / Q000209:etiology; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D017395:Plasminogen Activator Inhibitor 1; D015842:Serine Proteinase Inhibitors