title: Protein engineering and the development of generic biosensors.
abstract: Biosensors exploit the remarkable specificity of biomolecular recognition to provide analytical tools that can measure the presence of a single molecular species in a complex mixture. A new strategy is emerging in the development of biosensor technologies: molecular-engineering techniques are being used to adapt the properties of proteins to simple, generic detector instrumentation, rather than adapting instruments to the unique requirements of a natural molecule.
authors.affiliation: Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: H W
authors.initials: HW
authors.lastname: Hellinga
authors.forename: J S
authors.initials: JS
authors.lastname: Marvin
mesh_terms: D001665:Binding Sites; D015374:Biosensing Techniques; D011485:Protein Binding; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011506:Proteins