[Choice of therapeutic tactics in treatment of endogenous depression by means of statusmetric expert system].
There was elaborated expert models based on computer data base including 42 formalized signs (anamnesis, state of the patients, medical measures and indices of expert estimation of the response to therapy, based on the reduction of scores of Hamilton's scale). The study was carried out in 104 in-patients whose clinical states corresponded according to ICD-10 to category "depressive episode" and "recurrent depressive disorder". The patients were divided into 2 groups: in the first one the treatment was performed by serotoninergic antidepressants (SA)-fluoxetine (20 patients), fluvoxamine (20), sertraline (30). Tricyclic antidepressant (TAD) amitryptiline was administered to 34 patients of the second group. Two data bases were formed: responders to TAD and responders to SA. Natural pair model of classification (error of the model--12.5%) including 9 informative signs, was constructed, that gave chance to define probability sensitivity to TAD and SA. Check-up of computer model revealed that 3 patients of SA group didn't submit to decisive rule, while there were found 2 such patients in TAD application. Application of computer experiment permitted to turn from group prognosis to individual one.
Vovin
R Ia
RIa
Mazo
G E
GE
Razorenova
T S
TS
Razorenov
G I
GI
D015057:1-Naphthylamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D000639:Amitriptyline / Q000008:administration & dosage / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D005473:Fluoxetine / Q000008:administration & dosage / Q000627:therapeutic use; D016666:Fluvoxamine / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D012008:Recurrence; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D020280:Sertraline; D012720:Severity of Illness Index; D016896:Treatment Outcome
D015057:1-Naphthylamine; D000639:Amitriptyline; D000929:Antidepressive Agents, Tricyclic; D005473:Fluoxetine; D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline
Vybor terapevticheskoĭ taktiki s ispol'zovaniem statusmetricheskoĭ ékspertnoĭ sistemy pri lechenii éndogennykh depressiĭ.