Iron and copper transport in yeast and its relevance to human disease.
Recent progress in the field of copper and iron metabolism has resulted from a convergence of human and yeast genetics. The mechanisms of iron and copper transport are remarkably conserved between yeast and humans. Studies of the yeast homologs of human disease genes involved in metal homeostasis have shed light on the pathophysiology of these disorders.
Askwith
C
C
Department of Pathology, University of Utah, Salt Lake City 84132, USA.
Kaplan
J
J
D001693:Biological Transport, Active; D002462:Cell Membrane / Q000378:metabolism; D003300:Copper / Q000378:metabolism*; D005800:Genes, Fungal; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008664:Metal Metabolism, Inborn Errors / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*
D003300:Copper; D007501:Iron