Acute paraquat poisoning: increased toxicity in one case with high alcohol intake.
Human paraquat poisoning from accidental or intentional ingestion is very often fatal. According to the amount of paraquat involved, death can occur within hours or weeks following ingestion. The inefficacy of the various treatments undertaken have led to determine prognostic factors based upon the evolution of plasma and urine paraquat concentrations or of usual biochemical parameters. We report one case of acute poisoning which, although the ingested dose of paraquat was not massive (< 50 mg/kg-1) and the severity indices were in favour of a delayed fatal outcome, has ended in an early death. The high blood alcohol level of the patient (3.34 g l-1) seems to be the main cause of the precocity of this death (86th hour).
Ernouf
D
D
Laboratoire de Toxicologie, Faculté de Pharmacie, Tours, France.
Boussa
N
N
Legras
A
A
Dutertre-Catella
H
H
D000111:Acetylcysteine / Q000627:therapeutic use; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood; D000931:Antidotes / Q000627:therapeutic use*; D003676:Deferoxamine / Q000627:therapeutic use; D004234:Diuretics, Osmotic / Q000627:therapeutic use; D000431:Ethanol / Q000097:blood*; D005079:Excipients / Q000627:therapeutic use; D005100:Expectorants / Q000627:therapeutic use; D017809:Fatal Outcome; D006540:Herbicides / Q000097:blood / Q000506:poisoning*; D006801:Humans; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D008875:Middle Aged; D010269:Paraquat / Q000097:blood / Q000506:poisoning* / Q000652:urine; D011092:Polyethylene Glycols / Q000627:therapeutic use
D000931:Antidotes; D004234:Diuretics, Osmotic; D005079:Excipients; D005100:Expectorants; D006540:Herbicides; D000431:Ethanol; D008353:Mannitol; D011092:Polyethylene Glycols; D003676:Deferoxamine; D010269:Paraquat; D000111:Acetylcysteine