Cycloserine-induced decrease of cerebroside in myelin.
L-Cycloserine has been shown specifically to lower brain cerebroside levels in vivo, but the extent to which the decrease in whole brain cerebroside content reflects lower myelin cerebroside levels is not known since a substantial portion of cerebroside is found in nonmyelin membranes. The present report demonstrates that chronically administered cycloserine lowers the proportion of cerebroside in rat brain myelin. Cycloserine-induced decrease of myelin cerebroside should provide a useful tool in investigating the role of cerebroside in maintaining myelin stability.
Miller
S L
SL
Children's Hospital of Philadelphia and Department of Neurology, University of Pennsylvania School of Medicine, 19104, USA.
Denisova
L
L
D000818:Animals; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology* / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D003523:Cycloserine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005699:Galactosylceramides / Q000378:metabolism*; D009186:Myelin Sheath / Q000737:chemistry* / Q000187:drug effects* / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D011506:Proteins / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000904:Antibiotics, Antitubercular; D005699:Galactosylceramides; D010743:Phospholipids; D011506:Proteins; D003523:Cycloserine