IgG antibodies to chlamydial and mycoplasma infection plus C-reactive protein related to poor outcome in unstable angina.
OBJECTIVE
Evidence exists showing an association between Chlamydial infection and infarction. Our purpose was to identify an interactive relationship between Chlamydia pneumoniae and unstable angina.


METHODS
We analyzed IgG antibodies for Chlamydia pneumoniae, Mycoplasma pneumoniae, and C reactive protein in patients during the acute phase of unstable angina.


RESULTS
Chlamydia antibodies were present in 16.92% (11 cases) of the unstable angina patients. They were also present in 34.61% of those patients who experienced ischemic events vs 5.1% who did not (odds ratio 9.79, 95% CL 1.65 to 75.26, p = 0.002). Mycoplasma pneumoniae antibodies were present in 12.30% of patients but did not emerge as a predictive variable. C-reactive protein was present in 22 cases (33.84%), 9 of which were associated with recurrent events (34.61%) vs 13 which were free of them (odds ratio, p = 0.5). The interactive relationship between infection plus C-reactive protein achieved a statistical significant association with ischemic events (odds ratio 14, 95% CI 1.49-331.1; p = 0.003).


CONCLUSIONS
These findings suggest a pathophysiologically based relationship between infective and inflammatory processes related to poor clinical outcome during the in-hospital stay in the setting of unstable angina patients.
Gurfinkel
E P
EP
Coronary Care Unit, Favaloro Foundation, Buenos Aires, Argentina.
Rozlosnik
J
J
Bozovich
G
G
Duronto
E
E
Dos Santos
A
A
Mautner
B
B
D000789:Angina, Unstable / Q000097:blood* / Q000276:immunology / Q000382:microbiology; D000942:Antigens, Bacterial / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002690:Chlamydia Infections / Q000276:immunology*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009177:Mycoplasma pneumoniae / Q000276:immunology*; D017202:Myocardial Ischemia / Q000209:etiology; D011019:Pneumonia, Mycoplasma / Q000276:immunology*; D011379:Prognosis
D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D002097:C-Reactive Protein