Mucosal transmission of virulent and avirulent lentiviruses in macaques.
Sexual transmission of human immunodeficiency virus provides an efficient mode for virus spread and poses unique challenges to vaccine developers. Host and viral factors that affect transmission have been studied by epidemiological approaches in the human population, and some of these factors have been modeled with experimental infection of nonhuman primates. Basic principles have emerged regarding transmission and viral virulence. These ideas may be beneficial for designing a safe and effective vaccine.
Pauza
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CD
Wisconsin Regional Primate Center and Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, 53706, USA.
Horejsh
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D
Wallace
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M
D016915:AIDS Vaccines; D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D015658:HIV Infections / Q000635:transmission; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008253:Macaca mulatta; D009092:Mucous Membrane / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission*; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity*; D014774:Virulence
D016915:AIDS Vaccines