title: Anomalous fetal venous return associated with major chromosomopathies in the late first trimester of pregnancy.
abstract: We report three cases of increased nuchal translucency at 12-13 weeks of gestation in three fetuses with trisomies 13, 18 and 21. All three fetuses were associated with anomalous venous return evaluated by Doppler ultrasonography. Complete pathological examination was performed following termination in each case. We suggest that alterations in the venous compartment can be an early sign of poor outcome and should prompt a detailed search for cardiac defects early in gestation.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of S. João, Porto, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Matias
authors.forename: N
authors.initials: N
authors.lastname: Montenegro
authors.forename: J C
authors.initials: JC
authors.lastname: Areias
authors.forename: O
authors.initials: O
authors.lastname: Brandão
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000000981:diagnostic imaging*; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18; D004314:Down Syndrome / Q000000981:diagnostic imaging*; D005260:Female; D005865:Gestational Age; D006801:Humans; D009333:Neck; D011247:Pregnancy; D014314:Trisomy; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging; D014471:Umbilical Veins / Q000000981:diagnostic imaging; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging