[Leptin--an interim evaluation].
The discovery of leptin, the product of the obese (ob)-gene, has broadened the horizons of research on energy balance. This hormone, produced and secreted by adipose tissue and some placental cells, finds its way to the hypothalamus, where it binds to the leptin receptors and signals satiety through the neuroendocrine axis. The fact that adipose tissue is not merely a storage depot, but also an important endocrine tissue, has revived the interest in the "lipostatic" theory of body fat regulation and has initiated many research efforts in the field of obesity, anorexia nervosa, bulimia, reproduction and haematology.
Bodner
J
J
Universitiätsklinik für Innere Medizin, Innsbruck, Osterreich.
Ebenbichler
C F
CF
Lechleitner
M
M
Ritsch
A
A
Sandhofer
A
A
Gander
R
R
Wolf
H J
HJ
Huter
O
O
Patsch
J R
JR
D000273:Adipose Tissue / Q000503:physiopathology; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D020738:Leptin; D009490:Neurosecretory Systems / Q000503:physiopathology; D009765:Obesity / Q000503:physiopathology*; D011506:Proteins / Q000502:physiology*; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin
D002352:Carrier Proteins; C515448:LEPR protein, human; D020738:Leptin; D011506:Proteins; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin
Leptin--eine Zwischenbilanz.