title: [Polyclonal plasmacytosis in peripheral blood and leukocytoclastic vasculitis in Castleman's disease].
abstract: A 62 year-old man had fever, splenomegaly, systemic lymphadenopathy and palpable petechiae. Laboratory studies showed leukocytosis (10,200/microliters) with plasma cells (23%) and polyclonal gammopathy. Southern blot analysis of peripheral blood mononuclear cells showed no rearrangement of immunoglobulin genes, indicating polyclonal plasmacytosis in peripheral blood. A diagnosis of Castleman's disease was made by the cervical lymph node biopsy, which showed onion-skin structures in the germinal centers and plasmacytosis in the interfollicular region. A skin biopsy of the purpura lesion disclosed leukocytoclastic vasculitis. This is an unusual case of Castleman's disease presenting plasmacytosis in peripheral blood and leukocytoclastic vasculitis.
authors.affiliation: Division of Hematology, Kanto Teishin Hopital.
authors.forename: K
authors.initials: K
authors.lastname: Izutsu
authors.forename: K
authors.initials: K
authors.lastname: Usuki
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Endo
authors.forename: S
authors.initials: S
authors.lastname: Iki
authors.forename: S
authors.initials: S
authors.lastname: Matsuya
authors.forename: A
authors.initials: A
authors.lastname: Urabe
mesh_terms: D005871:Castleman Disease / Q000473:pathology*; D006801:Humans; D007964:Leukocytosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology / Q000473:pathology*