title: Novel and insecticidal isobutylamides from dinosperma erythrococca
abstract: Through insecticidal bioassay-guided fractionation and isolation, five isobutylamides 1-5 were isolated from n-hexane and EtOAc extracts of the aerial parts of Dinosperma erythrococca (Rutaceae). The structures of compounds 1-5 were established through 1D and 2D NMR. Compounds 1-3 were identified as erythrococcamides A-C and represent two novel classes of isobutylamide. Compounds 4-5 were identified as N-(2-hydroxy-2-methylpropyl)-6-phenyl-2(E), 4(E)-hexadienamide (4)1,2 and N-(2-methylpropyl)-6-phenyl-2(E), 4(E)-hexadienamide (5),1,3 respectively. Compound 1 showed lethal activity against the housefly (Musca domestica) (kill EC50 = 20.2 ppm) and the tobacco budworm (Heliothis virescens) (kill EC50 = 74.2 ppm). Compound 4 showed lethal activity against H. virescens at 500 ppm, while compound 5 showed lethal activity against M. domestica at 500 ppm.
authors.affiliation: Phytochemistry Research Laboratories, Department of Pharmaceutical Sciences, University of Strathclyde, George St., Glasgow G1 1XW, Scotland, U.K.
authors.initials: Z
authors.lastname: Latif
authors.initials: TG
authors.lastname: Hartley
authors.initials: MJ
authors.lastname: Rice
authors.initials: RD
authors.lastname: Waigh
authors.initials: PG
authors.lastname: Waterman