title: [Prevention from secondary nerve root adhesion: an experimental study].
abstract: In the study, 27 dogs were divided into three groups: A, B and C. Then all of the dogs had their lumbar intervertebral disks removed. Into the wounded cavity of group A, 1 ml of dimethicone was dropped and gelatin sponge was applied on the surface of the nerve root of group B. Group C was served as the control. The dogs were killed and the operation area was removed respectively 2 weeks, 4 weeks, and 12 weeks after the operation for macroscopical observation, nerve root motility measurement and histological examination. The result of the experiment proved that dimethicone was fairly effective in the prevention from secondary nerve root adhesion. While gelatin sponge in the process of its absorption induced the formation of quite a few scar tissues, thus aggrevating nerve root adhesion.
authors.affiliation: Department of Orthopaedics, Second Hospital of Harbin Medical University, Harbin.
authors.forename: M
authors.initials: M
authors.lastname: Yao
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: J
authors.initials: J
authors.lastname: Yan
mesh_terms: D000818:Animals; D004285:Dogs; D004643:Emollients / Q000627:therapeutic use*; D007403:Intervertebral Disc / Q000601:surgery*; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control; D012841:Simethicone / Q000627:therapeutic use*; D013126:Spinal Nerve Roots; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
chemical_list: D004643:Emollients; D012841:Simethicone