title: Pharmacologically active components of viticis fructus (Vitex rotundifolia). II. The components having analgesic effects.
abstract: The extract of Viticis Fructus appeared to have an analgesic effect, and was subjected to activity-guided separation using acetic acid-induced writhing in mice. The active fraction gave new compounds, vitexfolin A (1A), B and C, 10-O-vanilloylaucubin (3), dihydrodehydrodiconiferylalcohol-beta-D- (2'-O-p-hydroxybenzoyl)glucoside (4), and vanilloyl-beta-D-(2'O-p-hydroxybenzoyl)glucoside, together with agnuside (2) and erythro- and threoguaiacylglycerols. Compounds 1A and 2-4 showed significant writhing inhibition following oral administration at doses of 15, 50, 25, and 50 mg/kg, respectively. The effect on pressure pain threshold was tested using compounds 1A and 2 at a dose of 50 mg/kg, and only the former produced the analgesia. The analgesic effect of some related iridoid glucosides is also discussed.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Okuyama
authors.forename: S
authors.initials: S
authors.lastname: Fujimori
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Deyama
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D005638:Fruit / Q000737:chemistry; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology*; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D005960:Glucosides; D010936:Plant Extracts; C112273:vitexfolin A