title: A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism.
abstract: The possible association of the DRD2 locus, and in particular the Taql-A1 allele, with alcoholism remains controversial, in part because of differences in allele frequencies among populations. To avoid problems associated with differences in allele frequencies in different populations, we tested whether the DRD2 locus is associated with alcohol dependence in a large family-based sample. Neither the transmission/disequilibrium test nor the Affected Family-Based Controls test provide any evidence of linkage or association between the DRD2 locus and alcohol dependence.
authors.affiliation: Indiana University School of Medicine, Indianapolis 46202-5122, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: T
authors.initials: T
authors.lastname: Foroud
authors.forename: D L
authors.initials: DL
authors.lastname: Koller
authors.forename: A
authors.initials: A
authors.lastname: Goate
authors.forename: J
authors.initials: J
authors.lastname: Rice
authors.forename: P
authors.initials: P
authors.lastname: Van Eerdewegh
authors.forename: T
authors.initials: T
authors.lastname: Reich
authors.forename: C R
authors.initials: CR
authors.lastname: Cloninger
authors.forename: J I
authors.initials: JI
authors.lastname: Nurnberger
authors.forename: M
authors.initials: M
authors.lastname: Kowalczuk
authors.forename: B
authors.initials: B
authors.lastname: Wu
authors.forename: T K
authors.initials: TK
authors.lastname: Li
authors.forename: P M
authors.initials: PM
authors.lastname: Conneally
authors.forename: J A
authors.initials: JA
authors.lastname: Tischfield
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Shears
authors.forename: R
authors.initials: R
authors.lastname: Crowe
authors.forename: V
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: M
authors.initials: M
authors.lastname: Schuckit
authors.forename: B
authors.initials: B
authors.lastname: Porjesz
authors.forename: H
authors.initials: H
authors.lastname: Begleiter
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D002874:Chromosome Mapping; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008957:Models, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D012307:Risk Factors
chemical_list: D017448:Receptors, Dopamine D2