Transfusion-associated graft-versus-host disease in immunocompetent patient: early diagnosis and therapy.
We report a case of transfusion-associated graft-versus-host disease in a previously healthy, 68-year-old Japanese man following an emergency surgery for an acute aortic dissection. We confirmed the chimerism of lymphocytes and the effect of drug therapy using DNA polymorphism analysis. This method is a sensitive, convenient, and rapid method that it is also useful for the evaluation of therapy. And the combination therapy with methylprednisolone, cyclosporine, and 15-deoxyspergualin may be effective in treating transfusion-associated GVHD.
Sakurai
M
M
Department of Thoracic and Cardiovascular Surgery, Tohoku University School of Medicine, Sendai, Japan.
Moizumi
Y
Y
Uchida
S
S
Imai
Y
Y
Tabayashi
K
K
D000368:Aged; D000784:Aortic Dissection / Q000601:surgery; D001014:Aortic Aneurysm / Q000601:surgery; D016572:Cyclosporine / Q000627:therapeutic use; D004247:DNA / Q000235:genetics; D005938:Glucocorticoids / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D007121:Immunocompetence; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D018895:Microsatellite Repeats / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D013997:Time Factors; D065227:Transfusion Reaction
D005938:Glucocorticoids; D006146:Guanidines; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D004247:DNA; C037258:gusperimus; D008775:Methylprednisolone