title: Differences in D2 dopamine receptor binding in the neostriatum between cats hemidecorticated neonatally or in adulthood.
abstract: In order to study differences in response to neocortical injury sustained at different ages at the neurotransmitter level, we examined the density in D2 dopamine receptors in the neostriatum of cats hemidecorticated neonatally (N = 4) or in adulthood (N = 4), as well as in intact brains (N = 6). Receptor densities were measured using quantitative autoradiography and [3H]-spiperone binding in 12 regions of the neostriatum and nucleus accumbens septi. We found that the anterior lateral caudate nucleus on both sides of the brain contained a higher D2 receptor density in neonatal-lesioned as compared to adult-lesioned brains. Ipsilateral to the lesion, the increase was 101% (P < 0.05) and contralaterally it amounted to 77% (P < 0.05). Moreover, this region of the ipsilateral caudate nucleus of neonatal-lesioned cats tended to be more densely labeled than that of intact brain by 58% (P < 0.1). D2 receptor densities in adult-lesioned cats did not differ from that of intact controls. Comparison of these data with those of a former morphological study using the same animals suggested that this bilateral elevation of D2 receptor density in neonatally lesioned brains represents a higher mean density of binding sites per neuron. The elevation in the neonatal-lesioned cats might be a response of the striatum to neuroplastic changes in the striatal neuropil, including the corticostriatal afferents, since such changes are different in neonatal- as compared to adult-lesioned cats.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, USA. l.d.loopuyt@uni-tuebingen.de
authors.forename: L D
authors.initials: LD
authors.lastname: Loopuijt
authors.forename: D A
authors.initials: DA
authors.lastname: Hovda
authors.forename: A
authors.initials: A
authors.lastname: Ebrahim
authors.forename: J R
authors.initials: JR
authors.lastname: Villablanca
authors.forename: H T
authors.initials: HT
authors.lastname: Chugani
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002415:Cats; D002421:Caudate Nucleus / Q000378:metabolism*; D003655:Decerebrate State / Q000378:metabolism*; D011699:Putamen / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012016:Reference Values
chemical_list: D017448:Receptors, Dopamine D2