Effects of thrombolytic therapy on recanalization in different starting time of treatment after acute myocardial infarction.
OBJECTIVE
To investigate the effects of thrombolytic therapy on recanalization in different starting time of treatment after acute myocardial infarction.


METHODS
172 cases with intravenous thrombolytic agents were divided into 4 groups: < or = 2 hours, > 2-4 hours, > 4-6 hours and > 6-12 hours, according to the different starting time of therapy after onset of symptoms.


RESULTS
The recanalization rates were 78.6%, 74%, 39. 6% and 14.3% in < or = 2 hours, > 2-4 hours, > 4-6 hours and > 6-12 hours, respectively. The recanalization rate within 4 hours was significantly higher than those in the groups of > 4-6 hours AND > 6-12 hours. The time interval from the initiation of thrombolytic therapy to reperfusion was increased as the starting time of thrombolysis after onset of symptoms was delayed.


CONCLUSIONS
Starting time of thrombolysis within 4 hours after onset of acute myocardial infarction is of the best effect on recanalization.
Shen
L
L
Beijing Friendship Hospital, Capital University of Medical Science, China.
Yang
J
J
Hu
Q
Q
Teng
Y
Y
Han
X
X
Yan
S
S
Lian
M
M
Xie
M
M
Gu
F
F
D000368:Aged; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator