title: Apnea testing guided by continuous transcutaneous monitoring of partial pressure of carbon dioxide.
abstract: OBJECTIVE
  To continuously monitor PCO2 during two different protocols for apnea testing as part of the determination of brain death.
  
  
  METHODS
  Prospective comparative study using continuous transcutaneous PCO2 (tcPCO2) monitoring in 54 apnea tests with or without artificial CO2 augmentation. Another 53 apnea tests were not continuously monitored.
  
  
  METHODS
  Intensive care wards in Northern Bavaria.
  
  
  METHODS
  Ninety-six consecutive patients with suspected brain death.
  
  
  METHODS
  Apnea tests guided by transcutaneous monitoring during a PaCO2 of > or = 60 torr (> or = 8 kPa).
  
  
  RESULTS
  The mean of the difference between tcPCO2 and PaCO2 was -0.26 +/- 1.16 (SEM) torr (-0.035 +/- 0.15 kPa). Seventy percent of all transcutaneous measurements were within +/-10% of the PaCO2 values. The individual differences ranged from -25.8 to 16.9 torr (-3.44 to 2.25 kPa).
  
  
  CONCLUSIONS
  While not as precise as could be desired in individual cases, the overall agreement between tcPCO2 and PaCO2 was good. Transcutaneous monitoring aided in effectively reducing the CO2 target overshoot with artificial CO2 augmentation, reduced the necessary number of blood gas checks compared with a former study, using predetermined time-locked evaluations, and prolonged only tests with artificial CO2 augmentation.
authors.affiliation: Neurological Hospital, University of Erlangen-Nuremberg at Erlangen, Germany.
authors.forename: C J
authors.initials: CJ
authors.lastname: Lang
mesh_terms: D000328:Adult; D001049:Apnea / Q000097:blood / Q000175:diagnosis*; D001785:Blood Gas Monitoring, Transcutaneous / Q000379:methods*; D001926:Brain Death; D002245:Carbon Dioxide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged
chemical_list: D002245:Carbon Dioxide