Solid phase synthesis of benzamidine-derived sulfonamide libraries.
Using solid phase synthesis, a library has been constructed of benzamidine-derived sulfonamides which have strong inhibitory activity against blood coagulant thrombin. The library compounds were obtained in good yield and high purity.
Kim
S W
SW
Biotech Research Institute, LG Chemical Ltd., Science Town, Taejon, Korea.
Hong
C Y
CY
Koh
J S
JS
Lee
E J
EJ
Lee
K
K
D001550:Benzamidines / Q000138:chemical synthesis*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D015394:Molecular Structure; D012116:Resins, Plant; D013449:Sulfonamides / Q000138:chemical synthesis*; D013917:Thrombin / Q000037:antagonists & inhibitors
D001550:Benzamidines; D004791:Enzyme Inhibitors; D012116:Resins, Plant; D013449:Sulfonamides; D013917:Thrombin