[Prevention and therapy of acute radiation-related morbidity of the skin and mucosa. II, Recommendations of the literature].
BACKGROUND
In a German multicenter questionnaire, answered by 89 departments, we had examined the strategies to prevent or to treat the acute morbidity of the skin and mucosa associated to radiation therapy. In this work, the recommendations from the literature are compared to the results of the questionnaire.


METHODS
An extensive research on common data information systems (Medline, Cancerlit, DIMDI and others) was performed. The criteria included the organ related morbidity and therapeutic strategies for its reduction. The obtained data were compared to the results from the questionnaire.


RESULTS
The study data found by the research often demonstrate small patient numbers and little convincing results. However, as in the questionnaire, the joint principle seems to be the reduction of acute inflammatory tissue reaction by evasion of bacterial and mycotic overgrowth and reduction of exo- and endogenous toxins.


CONCLUSIONS
Further studies with more convincing results are required.
Zimmermann
J S
JS
Klinik für Strahlentherapie (Radioonkologie), Christian-Albrechts-Universität Kiel. zimmermann@onco.uni-kiel.de
Niehoff
P
P
Wilhelm
R
R
Schneider
R
R
Kovács
G
G
Kimmig
B
B
D000818:Animals; D018849:Controlled Clinical Trials as Topic; D004935:Esophageal Diseases / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D007413:Intestinal Mucosa / Q000528:radiation effects; D008297:Male; D009059:Mouth Diseases / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D009061:Mouth Mucosa / Q000528:radiation effects; D009092:Mucous Membrane / Q000528:radiation effects*; D015337:Multicenter Studies as Topic; D011446:Prospective Studies; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D011855:Radiodermatitis / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects*; D012002:Rectal Diseases / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D011795:Surveys and Questionnaires; D014627:Vaginitis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control; D014847:Vulvitis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D014987:Xerostomia / Q000209:etiology / Q000517:prevention & control / Q000628:therapy
Prophylaxe und Therapie akuter Strahlenfolgen an Haut und Schleimhaut. Teil II: Empfehlungen der Literatur.