Synthetic peptides as tools to investigate the structure and pharmacology of potassium channel-acting short-chain scorpion toxins.
In the last decade, numerous polypeptide toxins acting on ion channels have been isolated and characterized from diverse scorpion venoms. These toxins are useful pharmacological probes to study ion-specific channel proteins because they interact selectively with these channels and modulate their activities. Since low amounts of natural toxins can be isolated from scorpion venoms, the chemical synthesis approach is extremely useful to produce larger quantities of toxins and toxin analogs. This report is a succinct overview of the possibilities offered by the chemical synthesis to investigate pharmacological and structural properties of these compounds.
Lecomte
C
C
Laboratoire de Biochimie, Ingéniérie des Protéines, CNRS UMR 6560, IFR Jean Roche, Faculté de Médecine Nord, Marseille, France.
Sabatier
J M
JM
Van Rietschoten
J
J
Rochat
H
H
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry* / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D026902:Potassium Channel Blockers; D012604:Scorpion Venoms / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D009498:Neurotoxins; D010455:Peptides; D026902:Potassium Channel Blockers; D012604:Scorpion Venoms