title: Overview of the Second International Workshop to define swine cluster of differentiation (CD) antigens.
abstract: The aim of the Second International Swine Cluster of Differentiation (CD) Workshop, supported by the Veterinary Immunology Committee (VIC) of the International Union of Immunological Societies (IUIS), was to standardize the assignment of monoclonal antibodies (mAb) reactive with porcine leukocyte differentiation antigens and to define new antibody clusters. At the summary meeting of the workshop in July, 1995, revisions in the existing nomenclature for Swine CD were approved, so that the rules are now in accord with those for human and ruminant CD. Swine CD numbers will now be given to clusters of mAb to swine orthologues of human CD molecules when homology is proven by (1) suitable tissue distribution and lymphoid cell subset expression, (2) appropriate molecular mass of the antigen recognized by the mAbs, and (3) reactivity of mAbs with the cloned swine gene products, or cross-reactivity of the mAb on the human gene products. In some cases, this reactivity would not be fully proven, mainly due to the lack of cloned gene products; for these CD antigens, the respective clusters will be assigned by the prefix 'w' which will lead to 'wCD' antigens. As a result of the Second International Swine CD Workshop the assignment of 16 mAb to existing CD groups (CD2a, CD4a, CD5a, wCD6, wCD8, CD14, CD18a, wCD21, wCD25) was confirmed, and 2 mAb to existing swine workshop clusters (SWC). More importantly, for the work on the porcine immune system, was the definition of 5 new swine CD antigens, namely CD3 (recognized by 6 new mAb and 3 epitopes), CD16 (1 new mAb), wCD29 (2 mAb), CD45RA (3 mAb) and CD45RC (1 new mAb). Finally, the demarcation of two new SWC molecules in swine, SWC8 (2 mAb) and SWC9 (2 mAb) was confirmed.
authors.affiliation: Federal Research Centre for Virus Diseases of Animals, Tübingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Saalmüller
authors.forename: T
authors.initials: T
authors.lastname: Pauly
authors.forename: J K
authors.initials: JK
authors.lastname: Lunney
authors.forename: P
authors.initials: P
authors.lastname: Boyd
authors.forename: B
authors.initials: B
authors.lastname: Aasted
authors.forename: D H
authors.initials: DH
authors.lastname: Sachs
authors.forename: S
authors.initials: S
authors.lastname: Arn
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
authors.forename: R M
authors.initials: RM
authors.lastname: Binns
authors.forename: S
authors.initials: S
authors.lastname: Licence
authors.forename: A
authors.initials: A
authors.lastname: Whyte
authors.forename: F
authors.initials: F
authors.lastname: Blecha
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: R M
authors.initials: RM
authors.lastname: Chu
authors.forename: W C
authors.initials: WC
authors.lastname: Davis
authors.forename: S
authors.initials: S
authors.lastname: Denham
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: T
authors.initials: T
authors.lastname: Whittall
authors.forename: R M
authors.initials: RM
authors.lastname: Parkhouse
authors.forename: J
authors.initials: J
authors.lastname: Dominguez
authors.forename: A
authors.initials: A
authors.lastname: Ezquerra
authors.forename: F
authors.initials: F
authors.lastname: Alonso
authors.forename: G
authors.initials: G
authors.lastname: Horstick
authors.forename: C
authors.initials: C
authors.lastname: Howard
authors.forename: F
authors.initials: F
authors.lastname: Zuckermann
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000145:classification; D015703:Antigens, CD / Q000145:classification*; D013552:Swine / Q000276:immunology*; D009626:Terminology as Topic
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD