[Influence of different auxiliary materials on the dissolution of carbamazepine from solid dosage forms].
Results of the development of a solid dosage form containing 200 mg Carbamazepine (CBZ) are presented. Citric acid and low substituted Hydroxypropyl-cellulose (L-HPC) were used as dissolution enhancers of the active ingredient. Granulation the CBZ and citric acid with water has no effect on the dissolution of CBZ, but the granulation with absolute alcohol increases the dissolution rate. This enhancement could be explained with a molecular interaction between the CBZ and citric acid in water-free media. This interaction is indicated by the melting points, IR-spectra and scanning electron microscopy of the materials and granules. Further dissolution enhancement can be reached with L-HPC because of its disintegrating effect on the granules. Application of citric acid and L-HPC together results in extremely fast dissolution of the CBZ.
Jeköné
B Z
BZ
ICN Alkaloida Magyarország Rt., Tiszavasvári.
D002220:Carbamazepine / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives; D019343:Citric Acid; D004304:Dosage Forms; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D013055:Spectrophotometry, Infrared; D014867:Water
D004304:Dosage Forms; D014867:Water; D019343:Citric Acid; D002220:Carbamazepine; D002482:Cellulose; C008079:hydroxypropylcellulose
Különbözó segédanyagok hatása karbamazepin hatóanyag kioldódására szilárd gyógyszerformákból.