[Antioxidants in the combined therapy of diabetic angiopathies].
The participation of free-radical oxidation of lipids and polymers in the pathogenesis of diabetic angiopathies is analysed. The structure of the system of antioxidant protection and the mechanisms of damage to the vascular wall macromolecules in diabetic angiopathies is suggested. The protective effects of antioxidants in experimental studies and clinical practice are discussed. The conditions for and the principles of applying antioxidants in complex therapy of diabetic angiopathies are suggested.
Bobyreva
L E
LE
Ukranian Medical Stomatological Academy, Poltava, Ukraine.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004359:Drug Therapy, Combination; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects
D000975:Antioxidants; D005609:Free Radicals; D007004:Hypoglycemic Agents
Antioksidanty v kompleksnoĭ terapii diabeticheskikh angiopatiĭ.