title: Ethanolamine stimulates repair processes in acute CCl4 damage of mouse liver.
abstract: Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. Ethanolamine quickly reduced aminotransferase activity released in the serum, increased the hepatocellular nuclear BrdU uptake, a marker of S phase, and the epidermal growth factor (EGF) receptor content in the liver injured with CCl4. Thus, exogenous administration of ethanolamine may function as a liver proliferating factor in CCl4 intoxicated mouse liver.
authors.affiliation: Department of Pharmaceutics, Gifu Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: Y
authors.initials: Y
authors.lastname: Nagamura
authors.forename: K
authors.initials: K
authors.lastname: Hirano
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001973:Bromodeoxyuridine / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D004247:DNA / Q000096:biosynthesis; D066246:ErbB Receptors / Q000378:metabolism; D019856:Ethanolamine / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D051379:Mice; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism
chemical_list: D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D019856:Ethanolamine; D004247:DNA; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D066246:ErbB Receptors; D001973:Bromodeoxyuridine