Xanthones with antimalarial activity from Garcinia dulcis.
Chromatographic separation of the EtOH extract of the bark of Garcinia dulcis (Guttiferae) furnished five xanthones, viz 1,7-dihydroxyxanthone (1), 12b-hydroxy-des-D-garcigerrin A (2), 1-O-methylsymphoxanthone (3), symphoxanthone (4), and garciniaxanthone (5). These xanthones 1-5 showed inhibitory effects on the growth of Plasmodium falciparum with IC50 values of 0.96-3.88 micrograms/ml. In addition, revised 13C-NMR assignments of 3 and complete 13C-NMR assignments of 4 were obtained through analysis of their COSY, NOESY, HMQC, and HMBC spectra.
Likhitwitayawuid
K
K
Chanmahasathien
W
W
Ruangrungsi
N
N
Krungkrai
J
J
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010963:Plasmodium falciparum / Q000187:drug effects; D014966:Xanthenes / Q000302:isolation & purification* / Q000494:pharmacology*
D000962:Antimalarials; D014966:Xanthenes