Imidazolium triflate as an efficient promoter for O-selective phosphitylation of N-unprotected nucleosides via the phosphoramidite approach.
A novel method for the preparation of nucleotides via the phosphoramidite approach with imidazolium triflate 1 as a promoter has been developed. This approach required no protecting groups for nucleoside bases of building blocks.
Kataoka
M
M
Laboratory of Bioorganic Chemistry, Graduate School of Human Informatics, Nagoya University, Japan.
Heidenhain
S
S
Hayakawa
Y
Y
D015195:Drug Design; D015394:Molecular Structure; D009705:Nucleosides; D009711:Nucleotides / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds
D009705:Nucleosides; D009711:Nucleotides; D009943:Organophosphorus Compounds