Angiotensin-converting enzyme gene polymorphism in systemic hypertension.
We determined the angiotensin-converting enzyme (ACE) insertion/deletion genotype in 209 hypertensive individuals and in 100 matched normotensive controls. A significant association was detected between hypertension and the deletion/deletion (D/D) genotype of the ACE gene when the relation was adjusted for age, sex, and body mass index.
Abbud
Z A
ZA
TONE Clinical Center, Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903-0019, USA.
Wilson
A C
AC
Cosgrove
N M
NM
Kostis
J B
JB
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D004247:DNA / Q000032:analysis*; D015342:DNA Probes / Q000737:chemistry; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics; D008875:Middle Aged; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011897:Random Allocation; D015203:Reproducibility of Results
D015342:DNA Probes; D004247:DNA; D007703:Peptidyl-Dipeptidase A