title: Development of a novel synthetic material to close abdominal wall defects.
abstract: To compare the efficacy of a novel synthetic material (TMS-2) with polytetrafluoroethylene, polypropylene (Marlex), and primary closure of experimentally fashioned clean and contaminated abdominal wounds, 1-cm2 abdominal wall defects were created in each of the four abdominal quadrants of rats (n = 10). Patches of each material were used to repair three of these defects, the fourth being primarily closed. A second group of rats (n = 7) underwent the same operative protocol; however, peritonitis was induced at the time of surgery using a fecal inoculation technique. Animals were killed 2 weeks later, and surface area and severity of formed adhesions were assessed by a "blinded" observer. All closure techniques were successful insofar as none demonstrated fascial dehiscence. Compared with each synthetic material, the surface area of formed adhesions was smaller after primary closure in clean and in contaminated conditions; however, the three synthetic materials were equally matched regarding surface area of adhesions under both conditions. In the face of fecal contamination, TMS-2 proved identical to primary closure, each generating significantly (P < 0.02) milder adhesions than the other prosthetic materials. It is concluded that the TMS-2 may prove of clinical benefit to repair abdominal wall defects.
authors.affiliation: Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Cnota
authors.forename: S
authors.initials: S
authors.lastname: Aliabadi-Wahle
authors.forename: E U
authors.initials: EU
authors.lastname: Choe
authors.forename: J T
authors.initials: JT
authors.lastname: Jacob
authors.forename: L M
authors.initials: LM
authors.lastname: Flint
authors.forename: J J
authors.initials: JJ
authors.lastname: Ferrara
mesh_terms: D000009:Abdominal Muscles / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D006555:Hernia, Ventral / Q000473:pathology / Q000601:surgery*; D008297:Male; D011076:Polycarboxylate Cement; D011095:Polyethylenes; D011126:Polypropylenes; D011138:Polytetrafluoroethylene; D019919:Prosthesis Implantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012826:Silicone Elastomers; D013530:Surgical Wound Infection / Q000473:pathology / Q000601:surgery*; D013536:Suture Techniques; D014520:Urethane; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; C016674:Plastipore; D011076:Polycarboxylate Cement; D011095:Polyethylenes; D011126:Polypropylenes; D012826:Silicone Elastomers; C005506:polycarbonate; D014520:Urethane; D011138:Polytetrafluoroethylene