title: Immunoreactive endothelin levels in the vitreous fluid are decreased in diabetic patients with proliferative retinopathy.
abstract: Endothelin (ET) plays an important role in the pathogenesis of various cardiovascular lesions. To elucidate the pathophysiologic significance of ET in the development of diabetic retinopathy, we determined immunoreactive ET levels in the vitreous fluid collected during vitrectomy in seven patients with non-insulin dependent diabetes mellitus with proliferative diabetic retinopathy and in 10 nondiabetic subjects as controls. Immunoreactive vitreous ET levels in diabetic patients with proliferative retinopathy (7.5 +/- 3.4 pg/ml, mean +/- SD) were significantly lower than those in the nondiabetic subjects (55.0 +/- 38.1 pg/ml; p < 0.005). The decreased rather than increased immunoreactive ET levels may simply reflect severe endothelial injury to the retinal vessels caused by diabetic microangiopathy rather than an important role in diabetic retinopathy.
authors.affiliation: Department of Medicine, Tokyo Women's Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ogata
authors.forename: M
authors.initials: M
authors.lastname: Naruse
authors.forename: N
authors.initials: N
authors.lastname: Iwasaki
authors.forename: S
authors.initials: S
authors.lastname: Katoh
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
authors.forename: S
authors.initials: S
authors.lastname: Hori
authors.forename: H
authors.initials: H
authors.lastname: Demura
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamoto
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D003930:Diabetic Retinopathy / Q000378:metabolism*; D016232:Endothelins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D016232:Endothelins