A nerve distraction model in the rat.
Segmental loss of a peripheral nerve has been a challenging reconstructive problem. Management of the nerve gap has been accomplished classically with nerve grafting. However, autogenous nerve grafts are not always available for bridging large nerve gaps, and clinical results of large nerve cable grafts have been disappointing. Newer techniques concentrate on nerve lengthening with different methods. Tissue expansion of peripheral nerves has been producing promising results. Since the introduction of the Ilizarov external fixator, much attention has turned to limb-lengthening techniques and studies investigating the results of nerve and soft tissues lengthened during the course of this procedure. Primary nerve distraction may be an alternative to nerve elongation, by expansion or nerve grafting to repair the peripheral nerve gap. This study describes a device and a model for peripheral nerve distraction in a rat. Primary nerve distraction will need to be subjected to vigorous studies before clinical application.
Margiotta
M S
MS
Institute of Reconstructive Plastic Surgery, New York University Medical Center, NY 10016, USA.
Usal
H
H
Karp
N S
NS
Dublin
B K
BK
Sagiroglu
J
J
Ting
V
V
Kasabian
A K
AK
D000818:Animals; D051381:Rats; D017207:Rats, Sprague-Dawley; D019651:Plastic Surgery Procedures / Q000379:methods*; D012584:Sciatic Nerve / Q000293:injuries / Q000601:surgery*; D014143:Traction / Q000295:instrumentation