title: Angioscopy of culprit coronary lesions in unstable angina pectoris and correlation of clinical presentation with plaque morphology.
abstract: This study demonstrates that plaque disruption and thrombus are absent in a considerable number of patients with unstable angina and that culprit lesion morphologies as assessed by angioscopy may differ among the various clinical subsets of patients. Although plaque disruption and thrombus undoubtedly play an important role in the pathogenesis of unstable angina, alternative mechanisms may be responsible for ischemia in some patients.
authors.affiliation: Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Nesto
authors.forename: S
authors.initials: S
authors.lastname: Waxman
authors.forename: M A
authors.initials: MA
authors.lastname: Mittleman
authors.forename: M A
authors.initials: MA
authors.lastname: Sassower
authors.forename: P J
authors.initials: PJ
authors.lastname: Fitzpatrick
authors.forename: S M
authors.initials: SM
authors.lastname: Lewis
authors.forename: D E
authors.initials: DE
authors.lastname: Leeman
authors.forename: S J
authors.initials: SJ
authors.lastname: Shubrooks
authors.forename: K
authors.initials: K
authors.lastname: Manzo
authors.forename: S W
authors.initials: SW
authors.lastname: Zarich
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000175:diagnosis* / Q000209:etiology; D017546:Angioscopy; D003328:Coronary Thrombosis / Q000150:complications / Q000175:diagnosis*; D003331:Coronary Vessels / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D011446:Prospective Studies; D012008:Recurrence; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity