title: Carbohydrate-based combinatorial libraries.
abstract: Carbohydrate-based combinatorial libraries are tremendously valuable for studying the role of sugars in biology and for expanding accessible molecular diversity needed in broad-based drug screening programs. This review discusses the issues that are relevant to the successful implementation of comprehensive carbohydrate-based combinatorial library programs. In addition, details of oligosaccharide and glycoconjugate libraries constructed using both solid phase and solution phase strategies are presented.
authors.affiliation: Transcell Technologies Inc., Cranbury, NJ 08512, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Sofia
mesh_terms: D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis*; D006020:Glycopeptides / Q000138:chemical synthesis; D006031:Glycosylation; D037102:Lectins / Q000737:chemistry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis; D010457:Peptidoglycan / Q000737:chemistry; D037121:Plant Lectins; D011137:Polystyrenes / Q000378:metabolism
chemical_list: C039340:Bauhinia purpurea lectin; D002241:Carbohydrates; D006001:Glycoconjugates; D006020:Glycopeptides; D037102:Lectins; D009844:Oligosaccharides; D010457:Peptidoglycan; D037121:Plant Lectins; D011137:Polystyrenes; C101297:Tentagel resin