[Polyclonal plasmacytosis in peripheral blood and leukocytoclastic vasculitis in Castleman's disease].
A 62 year-old man had fever, splenomegaly, systemic lymphadenopathy and palpable petechiae. Laboratory studies showed leukocytosis (10,200/microliters) with plasma cells (23%) and polyclonal gammopathy. Southern blot analysis of peripheral blood mononuclear cells showed no rearrangement of immunoglobulin genes, indicating polyclonal plasmacytosis in peripheral blood. A diagnosis of Castleman's disease was made by the cervical lymph node biopsy, which showed onion-skin structures in the germinal centers and plasmacytosis in the interfollicular region. A skin biopsy of the purpura lesion disclosed leukocytoclastic vasculitis. This is an unusual case of Castleman's disease presenting plasmacytosis in peripheral blood and leukocytoclastic vasculitis.
Izutsu
K
K
Division of Hematology, Kanto Teishin Hopital.
Usuki
K
K
Inoue
K
K
Endo
M
M
Iki
S
S
Matsuya
S
S
Urabe
A
A
D005871:Castleman Disease / Q000473:pathology*; D006801:Humans; D007964:Leukocytosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology / Q000473:pathology*