title: Cardiac involvement in Dengue Haemorrhagic Fever.
abstract: We studied 17 consecutive patients of Dengue Haemorrhagic Fever/Dengue Shock Syndrome (DHF/DSS) to assess cardiac function by radionuclide ventriculography, echocardiography and electrocardiography (ECG) during the epidemic of Dengue virus type-2 (DEN-2) in Delhi, India (1996). Case definitions laid down by the WHO were followed. Fourteen patients were seropositive for Dengue infection. In radionuclide ventriculography study, the mean left-ventricular ejection fraction was 41.69 (5.04% (range 33-49%) and 7 patients had an ejection fraction less than 40%, global hypokinesia was detected in 12 (70.59%) patients. In echocardiography, the mean ejection fraction was 47.06 (3.8%). Eight patients had Dengue Shock Syndrome and the mean ejection fraction was 39.63% (4.97% in radionuclide ventriculography, out of which 5 patients had an ejection fraction below 40%. To find out the nature of myocardial involvement, 99m Tc-pyrophosphate imaging was done in 4 patients and it was discontinued further because no myocardial necrosis was detected in those patients. Five patients had ST and T changes in the electrocardiogram, radionuclide ventriculography and echocardiography revealed no abnormalities after 3 weeks of follow up and the ejection fraction was more than 50% in all cases. Global hypokinesia also improved and ECG changes reverted back to normal within 3 weeks. Acute reversible cardiac insult may be noticed in Dengue Haemorrhagic Fever/Dengue Shock Syndrome and could be responsible for hypotension/shock seen in some of these patients. Further studies are required to establish the pathogenic mechanisms of cardiac dysfunction in patients with Dengue Haemorrhagic Fever/Dengue Shock Syndrome.
authors.affiliation: AIIMS, Ansari Nagar, New Delhi, India.
authors.forename: J P
authors.initials: JP
authors.lastname: Wali
authors.forename: A
authors.initials: A
authors.lastname: Biswas
authors.forename: S
authors.initials: S
authors.lastname: Chandra
authors.forename: A
authors.initials: A
authors.lastname: Malhotra
authors.forename: P
authors.initials: P
authors.lastname: Aggarwal
authors.forename: R
authors.initials: R
authors.lastname: Handa
authors.forename: N
authors.initials: N
authors.lastname: Wig
authors.forename: V K
authors.initials: VK
authors.lastname: Bahl
mesh_terms: D000293:Adolescent; D000328:Adult; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis* / Q000209:etiology; D006334:Heart Function Tests; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D015635:Radionuclide Ventriculography; D012680:Sensitivity and Specificity; D019595:Severe Dengue / Q000150:complications*; D013318:Stroke Volume; D015996:Survival Rate; D014944:World Health Organization