title: Mechanistic investigation of photoreduction of 5-bromouracil-containing oligomers.
abstract: It was found that photoreduction of 5-bromouracil (BrU) occurs at 5'-ATBrU-3' sequence more efficiently than 5'-ABrU-3'. We introduced 5'-GG-3' sequence at the 5'-side of 5'-ATBrU-3' sequence and 5'-ABrU-3' sequence and investigated their photoreduction. As a result, dIz, an oxidation product originated from guanine cation radical, was detected.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fujimoto
authors.forename: S
authors.initials: S
authors.lastname: Ishihara
authors.forename: I
authors.initials: I
authors.lastname: Saito
mesh_terms: D001483:Base Sequence; D001976:Bromouracil; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000528:radiation effects; D010084:Oxidation-Reduction; D010777:Photochemistry; D011789:Quantum Theory; D013329:Structure-Activity Relationship
chemical_list: D009838:Oligodeoxyribonucleotides; D001976:Bromouracil