title: Morphological variation in folded duplex DNA chains.
abstract: I have monitored the packaging process of giant DNA chains with various condensing agents, such as polyamines, polyethylene glycol having pendant aminogroups and a lipospermine, under fluorescence microscopy. The detail morphological structure of the compacted DNA has been observed using electron microscopy. It has become clear that the difference in the folding process results in a large polymorphism of compacted DNA. I discuss the biological importance of controlling the compacted structure.
authors.affiliation: Department of Food and Nutrition, Nagoya Bunri College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshikawa
mesh_terms: D017122:Bacteriophage T4; D004247:DNA / Q000737:chemistry* / Q000187:drug effects / Q000648:ultrastructure; D004279:DNA, Viral / Q000737:chemistry; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D009690:Nucleic Acid Conformation / Q000187:drug effects; D010957:Plasmids / Q000737:chemistry; D011092:Polyethylene Glycols / Q000494:pharmacology; D013095:Spermidine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D004279:DNA, Viral; D011092:Polyethylene Glycols; D004247:DNA; D013095:Spermidine