Diabetes insipidus, Sheehan's syndrome and pregnancy.
OBJECTIVE
To study the role of vasopressin in osmoregulation in two successive pregnancies in a woman with Sheehan's syndrome.


METHODS
Diabetes insipidus (DI) became manifest during two pregnancies in a woman with postpartum hypopituitarism.


RESULTS
Water deprivation-vasopressin administration tests demonstrated partial central DI, corrected with vasopressin in week 12, but only with desmopressin in the third trimester, when placental cystylamino peptidase (vasopressinase) contributes to the severity of the DI.


CONCLUSIONS
If DI occurs during pregnancy it may be the first manifestation of a latent central DI, which is often idiopathic, but rarely the first symptom of a pituitary or hypothalamic abnormality. It may also be part of Sheehan's syndrome.
Briet
J W
JW
Department of obstetrics and gynaecology, Geertruiden Hospital, Deventer, Netherlands. gyndev@knmg.nl
D000328:Adult; D010122:Cystinyl Aminopeptidase / Q000378:metabolism; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005865:Gestational Age; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000175:diagnosis*; D009994:Osmolar Concentration; D010062:Ovulation Induction; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D011248:Pregnancy Complications; D014556:Urine; D014667:Vasopressins; D014868:Water Deprivation
D014667:Vasopressins; D010122:Cystinyl Aminopeptidase; D003894:Deamino Arginine Vasopressin