Arterio-venous ethanol levels in blood and plasma after intravenous injection in rabbits.
Arterio-venous ethanol concentrations in both whole blood and plasma were determined as a function of time in the rabbit. Following i.v. injection of 1.0 g/kg, both arterial and venous ethanol concentrations showed an abrupt decline occurring immediately after the end of the administration, followed by a pseudolinear phase that persisted for the length of the experiment. This work substantiates the arterio-venous ethanol concentration differences reported in the literature. It illustrates that equal arterial and venous ethanol concentrations may not be achieved readily after rapid i.v. injection. Moreover, it demonstrates a faster decay of ethanol concentrations in arterial than in venous plasma.
Kaltenbach
M L
ML
U.F.R. de Pharmacie, Laboratoire de Pharmacologie et de Pharmacocinétique, Reims, France. matthieu.kaltenbach@univ-reims.fr
Vistelle
R
R
Hoizey
G
G
Lamiable
D
D
Zbierski
L
L
D000818:Animals; D001158:Arteries; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood*; D007275:Injections, Intravenous; D008297:Male; D009994:Osmolar Concentration; D010949:Plasma / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors; D014680:Veins
D000431:Ethanol