title: Aggravation of focal epileptic seizures by antiepileptic drugs.
abstract: Aggravation of focal epileptic seizures in adults is common after the antiepileptic drug (AED) therapy is initiated. Sometimes aggravation is mimicked by clustering of the seizures. Therefore, it is always necessary to analyze the patient's history and therapy carefully before drawing any conclusions. It is likely that a paradoxical aggravation of epileptic seizures can be attributed to the given AED and is sometimes, but only rarely, due to drug interactions.
authors.affiliation: Epilepsy Clinic, University of Bonn, Germany.
authors.forename: C E
authors.initials: CE
authors.lastname: Elger
authors.forename: J
authors.initials: J
authors.lastname: Bauer
authors.forename: J
authors.initials: J
authors.lastname: Scherrmann
authors.forename: G
authors.initials: G
authors.lastname: Widman
mesh_terms: D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use; D000208:Acute Disease; D000328:Adult; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003509:Cyclohexanecarboxylic Acids; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D064420:Drug-Related Side Effects and Adverse Reactions; D004828:Epilepsies, Partial / Q000139:chemically induced* / Q000188:drug therapy; D000078328:Felbamate; D000077206:Gabapentin; D006801:Humans; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000009:adverse effects / Q000627:therapeutic use; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D048448:Phenylcarbamates; D011409:Propylene Glycols; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D020888:Vigabatrin; D000078328:Felbamate