title: Use of voriconazole in treatment of Scedosporium apiospermum infection: case report.
abstract: We report a case of disseminated Scedosporium apiospermum infection in a neutropenic patient with acute myeloid leukemia. Due to progression of the mycosis after 7 days of amphotericin B lipid complex therapy and to high susceptibility of the mold to voriconazole in vitro, the patient was treated with intravenous voriconazole. After a few days of therapy, fever disappeared and skin lesions improved. However, the patient died after 1 month due to intestinal bleeding. Despite a negative outcome, this case seems to indicate a promising role for voriconazole in the treatment of S. apiospermum infections.
authors.affiliation: Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy. GIRMENIA@BCE.MED.UNIROMA1.IT
authors.forename: C
authors.initials: C
authors.lastname: Girmenia
authors.forename: G
authors.initials: G
authors.lastname: Luzi
authors.forename: M
authors.initials: M
authors.lastname: Monaco
authors.forename: P
authors.initials: P
authors.lastname: Martino
mesh_terms: D000208:Acute Disease; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy* / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications; D008297:Male; D011541:Pseudallescheria; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole