Analysis of acetate counter ion and inorganic impurities in pharmaceutical drug substances by capillary ion electrophoresis with conductivity detection.
Capillary electrophoresis with conductivity detection is a versatile new method for the analysis of counter ions in pharmaceutical drug substances. It is a sensitive and linear technique for determining inorganic ions and short chain carboxylic acids such as acetate. Both acetate counter ion and inorganic impurities can be separated and determined in the same assay.
Wiliams
R C
RC
Pharmaceutical Research and Development, Experimental Station, DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0353, USA.
Boucher
R
R
Brown
J
J
Scull
J R
JR
Walker
J
J
Paolini
D
D
D000085:Acetates / Q000032:analysis*; D002021:Buffers; D002264:Carboxylic Acids / Q000032:analysis; D002852:Chromatography, Ion Exchange; D004340:Drug Contamination; D004553:Electric Conductivity; D019075:Electrophoresis, Capillary; D007202:Indicators and Reagents; D012015:Reference Standards
D000085:Acetates; D002021:Buffers; D002264:Carboxylic Acids; D007202:Indicators and Reagents