title: Comparative in-vitro activity of cefpirome against isolates from intensive care and haematology/oncology units. Belgian Multicentre Study Group.
abstract: The susceptibility of 389 Enterobacteriaceae, 231 other Gram-negative bacilli (including 150 Pseudomonas aeruginosa) and 233 Gram-positive organisms was determined by the NCCLS reference microdilution technique against cefpirome and other antibiotics. Cefpirome and cefepime were the most active compounds against Enterobacteriaceae, including potentially beta-lactamase-inducible species. The MIC90 of cefpirome against potentially inducible and non-inducible species of Enterobacteriaceae was 2 mg/L and 0.5 mg/L, respectively. Ceftazidime, cefpirome and cefepime had similar activity against P. aeruginosa, with MIC90s of 64 mg/L, 64 mg/L and 32 mg/L, respectively. Cefpirome and cefepime had similar activity against Gram-positive cocci, with MIC90s of 1 mg/L and 2 mg/L, respectively, against oxacillin-susceptible Staphylococcus aureus and 64 mg/L and 128 mg/L, respectively, against Enterococcus spp.; both had an MIC90 of 1 mg/L against Streptococcus pneumoniae. This study shows that fourth-generation cephalosporins, such as cefpirome, could be useful in haematology/oncology units and, in particular, ICUs where high resistance rates are observed.
authors.affiliation: Department of Microbiology, Akademisch Ziekenhuis Vrije Universiteit Brussels, Belgium. labomicro@az.vub.ac.be
authors.forename: D
authors.initials: D
authors.lastname: Piérard
authors.forename: K
authors.initials: K
authors.lastname: Emmerechts
authors.forename: S
authors.initials: S
authors.lastname: Lauwers
mesh_terms: D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000302:isolation & purification; D006405:Hematology; D006757:Hospital Units; D006801:Humans; D007362:Intensive Care Units; D008826:Microbial Sensitivity Tests; D016522:Oncology Service, Hospital; D018440:beta-Lactam Resistance; D000097572:Cefpirome
chemical_list: D000077723:Cefepime; D002511:Cephalosporins; D000097572:Cefpirome