The anticonvulsant zonisamide scavenges free radicals.
Zonisamide (ZNS) is effective in animal models of epilepsy and epileptic patients. The free radical scavenging activities of ZNS were analyzed by using electron spin resonance. ZNS, in the mmolar range, scavenged hydroxyl and nitric oxide radicals in a dose-dependent manner. This suggests that the mechanism of antiepileptic effect of ZNS may involve protection of neurons from free radical damage and stabilization of neuronal membranes.
Mori
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A
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.
Noda
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Y
Packer
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L
D000927:Anticonvulsants / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry; D012015:Reference Standards; D013481:Superoxides / Q000737:chemistry; D000078305:Zonisamide
D000927:Anticonvulsants; D016166:Free Radical Scavengers; D005609:Free Radicals; D007202:Indicators and Reagents; D007555:Isoxazoles; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D000078305:Zonisamide