title: The concordance of intraoperative left ventricular wall-motion abnormalities and electrocardiographic S-T segment changes: association with outcome after coronary revascularization. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.
abstract: BACKGROUND
  Transesophageal echocardiography (TEE) and Holter electrocardiography (ECG) are used to detect intraoperative ischemia during coronary artery bypass graft surgery (CABG). Concordance of these modalities and sensitivity as indicators of adverse perioperative cardiac outcomes are poorly defined. The authors tried to determine whether routine use of Holter ECG and TEE in patients with CABGs has clinical value in identifying those patients in whom myocardial infarction (MI) is likely to develop.
  
  
  METHODS
  A total of 351 patients with CABG and both ECG- and TEE-evaluable data were examined for the occurrence of ischemia and infarction. The TEE and five-lead Holter ECGs were performed continuously during cardiac surgery. The incidence of MI (creatine kinase-MB > or = 100 ng/ml) within 12 h of arrival in the intensive care [ICU] unit, new ECG Q wave on ICU admission or on the morning of postoperative day 1, or both, were recorded.
  
  
  RESULTS
  Electrocardiographic or TEE evidence of intraoperative ischemia was present in 126 (36%) patients. The concordance between modalities was poor (positive concordance = 17%; Kappa statistic = 0.13). Myocardial infarction occurred in 62 (17%) patients, and 32 (52%) of them had previous intraoperative ischemia. Of these, 28 (88%) were identified by TEE, whereas 13 (41%) were identified by ECG. Prediction of MI was greater for TEE compared with ECG.
  
  
  CONCLUSIONS
  Wall-motion abnormalities detected by TEE are more common than S-T segment changes detected by ECG, and concordance between the two modalities is low. One half of patients with MI had preceding ECG or TEE ischemia. Logistic regression revealed that TEE is twice as predictive as ECG in identifying patients who have MI.
authors.affiliation: Department of Anesthesia and Critical Care, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA. mcomunal@bidmc.harvard.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Comunale
authors.forename: S C
authors.initials: SC
authors.lastname: Body
authors.forename: C
authors.initials: C
authors.lastname: Ley
authors.forename: C
authors.initials: C
authors.lastname: Koch
authors.forename: G
authors.initials: G
authors.lastname: Roach
authors.forename: J P
authors.initials: JP
authors.lastname: Mathew
authors.forename: A
authors.initials: A
authors.lastname: Herskowitz
authors.forename: D T
authors.initials: DT
authors.lastname: Mangano
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D017548:Echocardiography, Transesophageal; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology; D017202:Myocardial Ischemia / Q000175:diagnosis*; D017063:Outcome Assessment, Health Care; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis