[Sublingual isosorbide-5 mononitrate during coronary arteriography. Comparison with sublingual nitroglycerin].
OBJECTIVE
To evaluate the effect of sublingual isosorbide-5 mononitrate (ISMN) and nitroglycerin (NTG) on luminal diameter of epicardial coronary arteries, mean arterial pressure and deleterious effects.


METHODS
Fifty patients were submitted to cardiac catheterization and coronary arteriography, at baseline, and 5 min after sublingual administration of ISMN, group A (GA) or NTG, group B (GB).


RESULTS
Reference vessel diameter increased in both groups, without statistical significance. In GA and GB, a decrease (1.66 mmHg) and an increase (0.79 mmHg) in mean arterial pressure, respectively, were demonstrated (p = 0.123). There were no deleterious effects with the use of these drugs.


CONCLUSIONS
Sublingual ISMN is an alternative to administration of NTG during coronary arteriography, and represents a therapeutic alternative to ischemic heart disease treatment.
Moreira
A E
AE
Instituto do Coração do Hospital das Clínicas, FMUSP.
Arie
S
S
Costa
E L
EL
Campos
L F
LF
Soares
P R
PR
Garcia
D P
DP
D000286:Administration, Sublingual; D001794:Blood Pressure / Q000187:drug effects*; D006328:Cardiac Catheterization; D002932:Cineangiography / Q000379:methods*; D003331:Coronary Vessels / Q000187:drug effects*; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
D014665:Vasodilator Agents; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate
Ação do mononitrato-5 de isossorbida sublingual durante cinecoronariografia. Comparação com o uso de nitroglicerina sublingual.