Solid phase synthesis of combinatorial libraries using anhydrides as templates.
A simple and general approach to the synthesis of chemical libraries based on a universal anhydride template allows the preparation of large number of compounds. Various cyclic/acyclic amines, primary/secondary amines, differentially protected bifunctional amines were used as nucleophiles to react with anhydrides. The free carboxylic acid generated was then coupled with solid-bound amines. The facile and rapid generation of compounds through this multi-component assembly can be accomplished in a combinatorial parallel synthesis.
Perumattam
J
J
Scios Inc., Sunnyvale, CA 94086, USA. perumattam@sciosinc.com
Chakravarty
S
S
McEnroe
G A
GA
Goehring
R R
RR
Mavunkel
B
B
Suravajjala
S
S
Smith
W W
WW
Chen
B
B
D000215:Acylation; D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000378:metabolism; D000812:Anhydrides / Q000737:chemistry*; D005449:Fluorenes / Q000378:metabolism; D015394:Molecular Structure; D012116:Resins, Plant
D000577:Amides; D000588:Amines; D000596:Amino Acids; D000812:Anhydrides; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D012116:Resins, Plant