The safety of pyrimethamine and sulfadoxine for the prevention of Pneumocystis carinii pneumonia.
The medical records of 157 patients taking pyrimethamine-sulfadoxine for Pneumocystis carinii pneumonia prophylaxis were reviewed for assessment of safety and tolerance. 11 patients had experienced side effects, 7 (1 each: neutropenia, Stevens-Johnson, hepatic abnormalities; 2 each: subjective and hypersensitivity reactions) leading to a discontinuation of the drugs.
Teira
R
R
Sección de Enfermedades Infecciosas, Hospital de Basurto, Bilbao, Spain.
Virosta
M
M
Muñoz
J
J
Zubero
Z
Z
Santamaría
J M
JM
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011010:Pneumocystis / Q000187:drug effects; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control*; D011739:Pyrimethamine / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced; D013413:Sulfadoxine / Q000009:adverse effects* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D013413:Sulfadoxine; D011739:Pyrimethamine