[Blood insulin and insulin sensitivity in breast cancer patients of various ages: the effect of smoking].
Blood-glucose and insulin were assayed by administering 40 g/sq.m glucose (per os) and 0.08 unit/kg body weight in 113 patients with early-stage breast tumors (glucose-tolerance test) and in 62 patients (insulin-sensitivity test). Sensitivity to insulin was assessed versus age, reproductive status, body size and smoker/non-smoker status. A direct correlation between high level of reactive insulinemia and obesity and an inverse one--between sensitivity to insulin and age were established on the basis of insulin test data and the insulin resistance factor. Smokers showed, on the average, lowered basal insulin levels and increased sensitivity to insulin (depending on age and number of cigarettes consumed). Smoking was found to influence prolactin reaction to hypoglycemia and to upset the correlation between age and progesterone receptor concentration in tumor which may account for certain peculiarities of the course of the disease in smokers with breast tumors.
Tsyrlina
E V
EV
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Gamaiunova
V B
VB
Kovalenko
I G
IG
Berstein
L M
LM
D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood*; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D012907:Smoking / Q000378:metabolism*
D006728:Hormones; D007328:Insulin
Insulin krovi i chuvstvitel'nost' k insulinu u bol'nykh rakom molochnoĭ zhelezy razlichnogo vozrasta: modifitsiruiushchee vliianie kureniia.