Antibacterial and anti-inflammatory agents that target endotoxin.
Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of lipopolysaccharide endotoxins in Gram-negative bacteria, is an intriguing target for new antibacterial and anti-inflammatory agents. Inhibition of lipid A biosynthesis kills most Gram-negative bacteria, increases bacterial permeability to antibiotics and decreases endotoxin production.
Wyckoff
T J
TJ
Dept of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
Raetz
C R
CR
Jackman
J E
JE
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008050:Lipid A / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000502:physiology; D008969:Molecular Sequence Data; D018805:Sepsis / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D008050:Lipid A