Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure.
We prospectively analyzed airway specimens from 24 newborn infants. Inhaled nitric oxide (< or = 20 ppm for 1 to 4 days to 12 infants) did not affect the concentrations of the lipid peroxidation product, the surface activity, or the cytokines (interleukin-1, granulocyte-macrophage colony-stimulating factor, interleukin-1 receptor antagonist). Nitrotyrosine was detected after 10 days of life in the two infants requiring prolonged ventilation, suggesting toxicity of endogenous nitric oxide.
Hallman
M
M
Department of Pediatrics, University of California, Irvine Medical Center, Orange, USA.
Bry
K
K
Turbow
R
R
Waffarn
F
F
Lappalainen
U
U
D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D010547:Persistent Fetal Circulation Syndrome / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D011446:Prospective Studies; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology* / Q000378:metabolism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000032:analysis
D016207:Cytokines; D009569:Nitric Oxide; C002744:3-nitrotyrosine; D014443:Tyrosine