Lead as an inductor of changes in the citrate transport to rat brain synaptic mitochondria.
The aim of the experiments presented here was to discern whether prolonged consumption of leaden water, that imitates environmental exposure, affects citrate transport to synaptic mitochondria. Our results indicate that during chronic lead intoxication both the velocity and the affinity of citrate transport to synaptic mitochondria decreased affecting the operation of Krebs cycle and consequently energetic processes in these mitochondria.
Waśkiewicz
J
J
Department of Neurochemistry, Polish Academy of Sciences, Warszawa.
Lenkiewicz
A
A
Rafałowska
U
U
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002951:Citrates / Q000378:metabolism*; D002952:Citric Acid Cycle / Q000187:drug effects*; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism
D002951:Citrates; D007854:Lead