[A comparative study of quantification of morphological changes in intracranial and extracranial arteries between cerebral hemorrhage and infarction].
In order to compare the difference and similarity of the pathological changes in intracranial and extracranial arteries between cerebral hemorrhage (CH) and cerebral Infarction (CI), 120 autopsy cases were studied, including 42 cases of the CH, 58 cases of the CI and 20 cases of cancer as control. Medium sized intracranial arteries and their main branches, small sized intracerebral arteries, arterioles and extracranial carotid arteries (from 14 cases only) were examined with light microscopy. The ratio of lumen area to vessel area (LA-VA ratio) and the degree of narrowing of the vessels indicating the severity of arteriosclerosis were determined. Quantitative analysis was carried out with computer. The results were as follows: (1) The CH and CI patients had significantly lower mean LA-VA ratios of the medium intracranial arteries and their main branches, small intracerebral arteries and arterioles than the controls. (2) The CH patients had apparently lower LA-VA ratio of the small intracerebral arteries and arterioles than the CI patients. (3) The CI patients had significantly lower LA-VA ratio of the medium sized intracranial arteries and their main branches than the CH patients. Moreover, atherosclerotic narrowing of these vessels was also much more severe in the CI than in the CH patients. (4) Atherosclerotic narrowing of the extracranial carotid artery in the CI patients was slightly more severe than that in the CH patients. These data suggest that patients with cerebral stroke have frequently atherosclerotic lesions in the medium sized intracranial arteries and their main branches and sclerotic lesions in the small intracerebral arteries and arterioles. The principal lesion of the CH are in the small intracerebral arteries and arterioles, while those of the CI in the medium sized intracranial arteries and their main branches and sometimes in the extracranial carotid arteries.
Liu
F
F
Beijing General Hospital of PLA.
Zhang
B
B
Tian
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D001160:Arterioles / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology*; D002536:Cerebral Arteries / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged