[Free radical mechanisms of radiation modification of DNA sugar fragment].
Analysis of the DNA and modeling its certain fragments substances radiolysis data allows to attribute the cardinal role to the primary 2-deoxyribosyl radicals in the processes of the breaks (C'3, C'5) and alkali-labile sites (C'1, C'2, C'4) in DNA strands, of the free bases appearance (C'3, C'5). The higher yield of bases destruction in DNA is explained by the transferring of a damage (unpaired electron) from 2-deoxyribosyl to a base within one nucleotide.
Sharpatyĭ
V A
VA
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow.
D004247:DNA / Q000528:radiation effects*; D053938:DNA Fragmentation; D003855:Deoxyribose; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals
D005609:Free Radicals; D003855:Deoxyribose; D004247:DNA
O svobodnoradikal'nykh mekhanizmakh radiatsionnoĭ modifikatsii sakharnogo fragmenta DNK.