[Acute thrombosis of the portal system. Treatment with alteplase and heparin or with heparin alone in 10 patients].
OBJECTIVE
We report the efficacy of alteplase (a recombinant tissue plasminogen activator) with heparin or heparin alone in the treatment of acute thrombosis of the portal venous system.


METHODS
Ten consecutive patients with acute portal venous system thrombosis were studied. Five patients were treated with alteplase and heparin, and the remaining 5 patients, who were asymptomatic or had a contraindication to alteplase, were treated with heparin alone.


RESULTS
In 3 of the 5 patients treated with alteplase, ultrasonography showed total resolution of the thrombus; the remaining 2 had partial resolution of the thrombus. In 4 of the 5 patients treated with heparin alone, ultrasonography showed total resolution of the thrombus, and no change in one. No bleeding occurred.


CONCLUSIONS
Treatment with heparin can result in complete recanalisation of acute portal venous system thrombosis. These data suggest that combined therapy with systemic alteplase does not increase the efficacy of heparin.
Lagasse
J P
JP
Service d'Hépato-Gastroentérologie, CHR, Orléans.
Bahallah
M L
ML
Salem
N
N
Debillon
G
G
Labarrière
D
D
Serve
M P
MP
Advenier
V
V
Causse
X
X
Legoux
J L
JL
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011168:Portal System; D012189:Retrospective Studies; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D006493:Heparin; D010959:Tissue Plasminogen Activator
Thrombose aiguë du système porte. Traitement par alteplase et héparine ou héparine seule chez 10 malades.