title: Regulation of chloride channels in secretory epithelia.
abstract: Fluid and electrolyte secretion from secretory epithelia is a highly regulated process. Chloride channel activity at the apical membrane determines the rate and direction of salt and water secretion. Multiple classes of Cl- channels with distinct gating mechanisms are involved in moving ions and water. Secretory agonists that induce intracellular increases in two second messenger systems, cAMP and [Ca2+]i, are generally associated with secretion. However, changes in cell volume and the membrane potential may also play a role in regulating fluid and electrolyte secretion in some tissues. In this review we discuss the regulation of the different types of Cl- channels found in secretory epithelia.
authors.affiliation: Rochester Institute of Biomedical Sciences, Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
authors.forename: T
authors.initials: T
authors.lastname: Begenisich
authors.forename: J E
authors.initials: JE
authors.lastname: Melvin
mesh_terms: D000818:Animals; D018118:Chloride Channels / Q000145:classification / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D004848:Epithelium
chemical_list: D018118:Chloride Channels