Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva.
A 2-year-old child with fibrodysplasia ossificans progressiva underwent a muscle biopsy of a very early lesion, and had findings that showed the earliest stage ever seen in the histopathology of fibrodysplasia ossificans progressiva. This very early stage consisted of intense perivascular lymphocytic infiltration into normal appearing skeletal muscle. A nearly identical histopathologic sequence was noted in a cat with phenotypic features similar to those of fibrodysplasia ossificans progressiva in humans. These new findings represent the earliest documented changes that have ever been noted in fibrodysplasia ossificans progressiva, and provide further histopathologic support for the recent discovery that lymphocytes may play a role in the pathogenesis of heterotopic ossification in fibrodysplasia ossificans progressiva.
Gannon
F H
FH
Division of Metabolic Bone Diseases and Molecular Orthopaedics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Valentine
B A
BA
Shore
E M
EM
Zasloff
M A
MA
Kaplan
F S
FS
D000818:Animals; D018951:Antigens, CD20 / Q000032:analysis; D055396:Bone Morphogenetic Protein 2; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D002415:Cats; D002465:Cell Movement; D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens / Q000032:analysis; D008214:Lymphocytes / Q000737:chemistry / Q000473:pathology*; D008297:Male; D009221:Myositis Ossificans / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000032:analysis
D018951:Antigens, CD20; C525718:BMP2 protein, human; C525809:BMP4 protein, human; D055396:Bone Morphogenetic Protein 2; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; D017252:CD3 Complex; D016212:Transforming Growth Factor beta; D017493:Leukocyte Common Antigens