Inhibition of leukocyte adhesion: an alternative mechanism of action for anti-inflammatory drugs.
It has been widely accepted that the mechanism of action of nonsteroidal anti-inflammatory drugs (NSAIDs) is the inhibition of prostaglandin synthesis. However, a significant body of evidence suggests that NSAIDs have additional anti-inflammatory mechanisms of action. Here, Federico Díaz-González and Francisco Sánchez-Madrid discuss novel effects of NSAIDs on leukocyte adhesion pathways that may help in the development of new anti-inflammatory agents that selectively block cell adhesion molecules.
Díaz-González
F
F
Service of Rheumatology, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain.
Sánchez-Madrid
F
F
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000187:drug effects; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000187:drug effects / Q000276:immunology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015815:Cell Adhesion Molecules