[Inhaled budesonide versus intramuscular dexamethasone in the treatment of pseudo-croup].
We randomised 59 children hospitalized for croup to treatment with either inhaled budesonide or injected dexamethasone. Group A were treated with two inhalations of 1000 micrograms budesonide and group B received dexamethasone 0.6 mg/kg intramuscularly. We used a modified Westley-score, based on chest-wall retractions, barking cough, respiratory frequency and stridor. The children was aged three months to six years (mean 20 months). Three hours after the first treatment there was significant improvement in score amongst all children (p < 0.001), but no difference between the two groups (p < 0.20). Six and 12 hours after the first treatment there were significantly better clinical scores in group B (p = 0.001, p = 0.0004). Based on this study we recommend dexamethasone 0.6 mg/kg intramuscularly for children to be treated for croup.
Pedersen
L V
LV
Esbjerg Centralsygehus, paediatrisk afdeling.
Dahl
M
M
Falk-Petersen
H E
HE
Larsen
S E
SE
D000280:Administration, Inhalation; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D019819:Budesonide / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003440:Croup / Q000188:drug therapy*; D003907:Dexamethasone / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019819:Budesonide; D003907:Dexamethasone
Inhaleret budesonid versus dexamethason i.m. til behandling af pseudocroup.