Photoreaction of 5-halouracil-containing Z-form DNA.
Photoreactions of IU-containing Z-form DNA were investigated. By introducing 8-methylguanine, stable Z-form IU-containing oligonucleotides were prepared. DNA conformational change from B to Z leads to the remarkable acceleration of the photoreactivity of IU-containing oligonucleotides. In particular 2'-hydrogen abstraction was observed preferentially in Z-form DNA, and 2'-hydroxylation occurred specifically at the 5' side of IU in Z-form DNA.
Kawai
K
K
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
Sugiyama
H
H
Saito
I
I
D001483:Base Sequence; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000031:analogs & derivatives*; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D010777:Photochemistry; D014498:Uracil / Q000031:analogs & derivatives*
D009838:Oligodeoxyribonucleotides; C066771:8-methylguanine; D014498:Uracil; D006147:Guanine; D004247:DNA; C048747:5-iodouracil