Micacocidin A, B and C, novel antimycoplasma agents from Pseudomonas sp. II. Structure elucidation.
Metal-containing novel heterocyclic antibiotics, micacocidin A (1), B (2), and C (3) have been isolated from the culture filtrate of Pseudomonas sp. No. 57-250. The structure and absolute configuration of micacocidin A, an octahedral Zn2+ complex, was determined by X-ray crystallographic analysis. And then, the structures of the two congeners, micacocidin B (Cu2+ complex) and C (Fe3+ complex) were investigated by employing one dimensional and two dimensional homonuclear and heteronuclear NMR spectroscopies and mass spectrometry.
Kobayashi
S
S
Aburahi Laboratories, Shionogi & Co., Ltd., Japan.
Nakai
H
H
Ikenishi
Y
Y
Sun
W Y
WY
Ozaki
M
M
Hayase
Y
Y
Takeda
R
R
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009174:Mycoplasma / Q000187:drug effects*; D009942:Organometallic Compounds / Q000737:chemistry*; D011549:Pseudomonas / Q000378:metabolism
D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; C112186:micacocidin A; C112187:micacocidin B; C112188:micacocidin C