Differences in plasma concentrations of the D- and L-threo methylphenidate enantiomers in responding and non-responding children with attention-deficit hyperactivity disorder.
Children with attention-deficit hyperactivity disorder who are categorized as responders or non-responders to methylphenidate (MPH) on the basis of their electrophysiological P3 response in a selective attention task differ in metabolic patterns of the D- and L-threo MPH enantiomers. Non-responders showed significantly higher plasma concentrations of both D- and L-threo MPH enantiomers.
Jonkman
L M
LM
Faculty of Social Sciences, Department of Psychonomics, Utrecht University, The Netherlands. L.Jonkman@FSW.RUU.NL
Verbaten
M N
MN
de Boer
D
D
Maes
R A
RA
Buitelaar
J K
JK
Kemner
C
C
van Engeland
H
H
Koelega
H S
HS
D000704:Analysis of Variance; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood* / Q000145:classification / Q000188:drug therapy / Q000503:physiopathology; D000697:Central Nervous System Stimulants / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D002648:Child; D004351:Drug Resistance; D018913:Event-Related Potentials, P300 / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007536:Isomerism; D008297:Male; D008774:Methylphenidate / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D014836:Volition / Q000187:drug effects / Q000502:physiology
D000697:Central Nervous System Stimulants; D008774:Methylphenidate