title: Effect of vitamin D3 and 1,25(OH)2D3 on growth of neoplastically derived cell lines and their alkaline phosphatase activity.
abstract: Inhibitory effects of 1,25(OH)2D3 and D3 on growth of four neoplastically derived cells were observed in human acute leukemia cell culture CEM-C-1 and CEM-C-7, human cervical carcinoma cell lines C-4-1 and human epithelioid carcinoma cells of cervix HeLa S3K. Concurrently, in dexamethasone-responsive cells C-4-1 and HeLa S3K there was a 1,25(OH)2D3 and D3 induced elevation of alkaline phosphatase with 1,25(OH)2D3 showing the greater effects. It is supposed that vitamins D3-induced alkaline phosphatase activity in malignant cells, which is proposed to be a possible marker of cell differentiation, can be associated with the membrane effects of these vitamins.
authors.affiliation: Kansas City VA Medical Center, USA.
authors.lastname: Kholodova YuD
authors.forename: O P
authors.initials: OP
authors.lastname: Bondar
authors.forename: G
authors.initials: G
authors.lastname: Melnykovych
mesh_terms: D000208:Acute Disease; D000469:Alkaline Phosphatase / Q000096:biosynthesis / Q000378:metabolism*; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology; D002117:Calcitriol / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002762:Cholecalciferol / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007938:Leukemia; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms
chemical_list: D018931:Antineoplastic Agents, Hormonal; D005938:Glucocorticoids; D002762:Cholecalciferol; D003907:Dexamethasone; D000469:Alkaline Phosphatase; D002117:Calcitriol