title: Effect of glucose supplementation on appetite and the pyloric motor response to intraduodenal glucose and lipid.
abstract: The effects of different macronutrients on appetite and pyloric motility and the impact of short-term dietary glucose supplementation on these responses were evaluated. Ten males (aged 19-38 yr) received isocaloric (2.9 kcal/min) intraduodenal infusions of glucose and lipid while antropyloroduodenal motility and appetite were assessed by manometry and visual analog scales, respectively. Effects of each intraduodenal nutrient on appetite and motility were evaluated before and after 7 days of dietary supplementation with glucose (400 g daily). Initially, both nutrients caused a similar rise in pyloric tone, but intraduodenal lipid was a more potent stimulus of phasic pyloric motility (P = 0.05) and suppressed appetite more (P = 0.013) than intraduodenal glucose. After dietary glucose supplementation, the increase in pyloric tone during intraduodenal glucose was attenuated. Although intraduodenal lipid remained a more potent stimulant of phasic pyloric motility (P = 0.016), it no longer decreased appetite. We conclude that in healthy young males 1) intraduodenal infusion of lipid is a more potent stimulus of phasic pyloric motility and suppresses appetite more than intraduodenal glucose and 2) dietary glucose supplementation alters both the appetite suppressant effect of intraduodenal lipid and the pyloric motor response to intraduodenal glucose infusion.
authors.affiliation: Department of Medicine, Royal Adelaide Hospital, Australia.
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.forename: S
authors.initials: S
authors.lastname: Doran
authors.forename: G S
authors.initials: GS
authors.lastname: Hebbard
authors.forename: G
authors.initials: G
authors.lastname: Rassias
authors.forename: W M
authors.initials: WM
authors.lastname: Sun
authors.forename: M
authors.initials: M
authors.lastname: Horowitz
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis; D004032:Diet; D004064:Digestive System / Q000187:drug effects; D004068:Digestive System Physiological Phenomena; D004386:Duodenum / Q000378:metabolism*; D005223:Fats / Q000008:administration & dosage* / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007441:Intubation, Gastrointestinal; D008297:Male; D009994:Osmolar Concentration; D011312:Pressure; D011708:Pylorus / Q000187:drug effects* / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D005223:Fats; D007328:Insulin; D005947:Glucose