A UVB phototherapy protocol with very low dose increments as a treatment of atopic dermatitis.
From 1991 to 1992, 15 patients with atopic dermatitis were treated with a new UVB treatment regimen guided by skin reflectance measurements. The new treatment was characterized by very low dose increments from start to end of therapy. The median cumulative dose increment during therapy was only 20%. The severity of the disease, the efficacy of the treatment, the occurrence of adverse effects and the cumulative UVB dose were obtained from the case records. This data were compared in an open study with the data obtained from 17 patients with atopic dermatitis who were treated from 1988 to 1991 at the department with a standard UVB treatment regimen with stepwise dose increments. There was no difference in the severity of the disease at the beginning of the therapy between the two groups. The skin reflectance-guided low-dose UVB therapy was not significantly faster (3.5 weeks) than the regimen with stepwise dose increments (4.5 weeks). The cumulative UV exposure was four times lower with the new treatment regimen (34 standard erythema doses) compared with the old regimen (161 standard erythema doses), P<0.001. The healing score was significantly higher with the new treatment regimen compared with the old, P<0.05. This study indicates that skin reflectance-guided UVB phototherapy may enable the dermatologist to lower the cumulative UVB exposure significantly without losing effect.
Wulf
H C
HC
Department of Dermatology, Copenhagen University Hospital, Denmark.
Bech-Thomsen
N
N
D000328:Adult; D003876:Dermatitis, Atopic / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D014467:Ultraviolet Therapy / Q000379:methods