title: Light and electron microscopic observations on rat molar periodontal ligament after intraperitoneal injection of vinblastine.
abstract: The effect of intraperitoneal injection of Vinblastine sulfate on rat periodontal ligament was studied. Cells still synthetize collagen after 2 hours of the injection with evidence of loss of extracellular collagen fibers orientation. Tubular lysosome could not be detected after 2 hours with formation of lysosomal clusters in the cell center. After 4 hours of administration, evidences of cell degeneration were observed. The present study has shown that Vinblastine produces effect on fibroblasts as early as two hours after injection.
authors.affiliation: Faculty of Oral and Dental Medicine, Cairo University.
authors.forename: A H
authors.initials: AH
authors.lastname: Salama
authors.forename: N A
authors.initials: NA
authors.lastname: Lashin
authors.forename: M A
authors.initials: MA
authors.lastname: Ali
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000633:toxicity*; D003094:Collagen / Q000096:biosynthesis / Q000187:drug effects / Q000648:ultrastructure; D006651:Histocytochemistry; D007274:Injections, Intraperitoneal; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D008854:Microscopy, Electron; D008963:Molar; D010513:Periodontal Ligament / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D003094:Collagen; D017766:Acid Anhydride Hydrolases; C022768:trimetaphosphatase