Mapping of provisional quantitative trait loci influencing temporal variation in locomotor activity in the LS x SS recombinant inbred strains.
The finding that stress-induced locomotor activity exhibited a significant strain x time interaction in the LS x SS RI strains prompted examination of QTL influencing this behavior as a function of time. The degree of genetic determination for locomotor activity was 0.26 for the first 5 min and decreased to 0.16 for the last 5 min of a 30-min test but the number of genetic factors stayed relatively constant (three or four) across time. A QTL point analysis revealed a total of 15 QTL, 5-8 per 5-min time block. Few of the QTL were detected across all time points and different combinations of QTL were evident for each time period. Five of the QTL were in common with those reported by other investigators for similar behaviors. The results suggest that locomotor behavior is under a greater degree of genetic control during the initial part of the test but environmental factors become increasingly important as the test progresses. Furthermore, different genetic factors appear to be mediating genetic variation in locomotor behavior at any given time point.
Radcliffe
R A
RA
Institute for Behavioral Genetics, University of Colorado, Boulder 80309-0447, USA. radclifr@colorado.edu
Jones
B C
BC
Erwin
V G
VG
D000704:Analysis of Variance; D000818:Animals; D002874:Chromosome Mapping; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009043:Motor Activity / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D011995:Recombination, Genetic / Q000235:genetics*; D012044:Regression Analysis; D013996:Time and Motion Studies