title: PSA and bone scintigraphy.
abstract: The authors evaluate the role of prostate specific antigen (PSA) and bone scintigraphy in the follow-up of radical prostatectomy-treated and radiotherapy-treated patients. 784 patients were evaluated by simultaneous PSA assay and bone scans. The correlation between PSA levels and extension of bone metastases was good. The frequency of extraskeletal metastases was low: only 13 patients had soft tissue metastases without bone involvement and 33/138 patients with bone metastases had also extraskeletal metastases. The results underline the importance of PSA and the possibility to omit bone scan when the PSA level is below 8 ng/ml in patients who did not undergo anti-androgenic treatments.
authors.affiliation: Nuclear Medicine and Tumor Markers Unit, Hospital Casa Sollievo della Sofferenza, San Giovanni Rotondo (Fg), Italy.
authors.forename: S
authors.initials: S
authors.lastname: Modoni
authors.forename: E
authors.initials: E
authors.lastname: Calò
authors.forename: G
authors.initials: G
authors.lastname: Nardella
authors.forename: G
authors.initials: G
authors.lastname: Ritrovato
authors.forename: V
authors.initials: V
authors.lastname: Frusciante
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001774:Blood Chemical Analysis / Q000191:economics; D001859:Bone Neoplasms / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003131:Combined Modality Therapy; D003363:Cost Control; D003955:Diagnostic Tests, Routine / Q000191:economics; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000532:radiotherapy / Q000601:surgery; D011877:Radionuclide Imaging / Q000191:economics; D018714:Radiotherapy, Adjuvant; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen