A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease.
In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.
Checkoway
H
H
Department of Environmental Health, University of Washington, Seattle 98195-7234, USA.
Franklin
G M
GM
Costa-Mallen
P
P
Smith-Weller
T
T
Dilley
J
J
Swanson
P D
PD
Costa
L G
LG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D010300:Parkinson Disease / Q000209:etiology* / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
D008995:Monoamine Oxidase