title: Molecular mechanisms of antisense drugs: RNase H.
authors.affiliation: Isis Pharmaceuticals, Inc., Carlsbad, CA 92008, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Crooke
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D003001:Cloning, Molecular; D006801:Humans; D046911:Macromolecular Substances; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000494:pharmacology*; D011485:Protein Binding; D014176:Protein Biosynthesis / Q000187:drug effects; D012313:RNA / Q000187:drug effects / Q000378:metabolism; D016914:Ribonuclease H / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D001426:Bacterial Proteins; D046911:Macromolecular Substances; D016376:Oligonucleotides, Antisense; D012313:RNA; D016914:Ribonuclease H