Cellular effects of hypercholesterolemia in modulation of cancer growth and metastasis: a review of the evidence.
Hypercholesterolemia and increased cancer risk have been associated, particularly with the high fat diets characteristic of Western societies. We were interested in the possible association between preexisting hypercholesterolemia and the rapidity and extent of tumor metastases in these patients. To date there has been only a few studies that have suggested and explored this determinant of cancer metastases although it may play a role in a subset of patients who develop cancers. This article will review the literature on the effects of LDL-cholesterol on cell proliferation and differentiation and speculate on mechanisms of involvement of a hypercholesterolemic milieu on cancer progression and enhancement of metastatic potential.
Mehta
N
N
Department of Surgery, VA Medical Center, State University of New York at Buffalo, 14215, USA.
Hordines
J
J
Volpe
C
C
Doerr
R
R
Cohen
S A
SA
D000818:Animals; D008078:Cholesterol, LDL / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D011379:Prognosis
D008078:Cholesterol, LDL; D004041:Dietary Fats