Synthesis of nucleosides having unusual branched sugars as potential antiviral agents.
Enantiomerically pure novel nucleosides having unusual branched sugars were synthesized in a stereospecific manner from a common chiral pool of (S, S)-1,4-bis(benzyloxy)-2,3-epoxybutane and evaluated for antiviral activity.
Kato
K
K
Research Laboratories, Nippon Kayaku Co. Ltd., Tokyo.
Nishiyama
S
S
Yamamura
S
S
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002073:Butanes; D002460:Cell Line; D002522:Chlorocebus aethiops; D015195:Drug Design; D004852:Epoxy Compounds; D015497:HIV-1 / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D014709:Vero Cells
D000998:Antiviral Agents; D002073:Butanes; D004852:Epoxy Compounds; D007202:Indicators and Reagents; D009705:Nucleosides