title: Skin signs in the diagnosis of thallium poisoning.
abstract: A 45-year-old man developed a painful and rapidly progressive sensory-motor polyneuropathy associated with confusion and convulsions. This resulted in hypoventilation and led to respiratory failure and coma. A rapid and diffuse alopecia occurred after 3 weeks in the intensive care unit. Examination of hair roots under polarized light detected dystrophic anagen hairs with dark bands caused by empty spaces in the disorganized cortex. These dark zones were originally reported in patients with thallium poisoning and a toxicological investigation confirmed thallium exposure. The classical systemic symptoms and the various dermatological signs are reviewed, and the origins of contamination and physiopathology discussed.
authors.affiliation: Department of Dermatology, Clinique Saint Pierre, Ottignies, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Tromme
authors.forename: D
authors.initials: D
authors.lastname: Van Neste
authors.forename: F
authors.initials: F
authors.lastname: Dobbelaere
authors.forename: B
authors.initials: B
authors.lastname: Bouffioux
authors.forename: C
authors.initials: C
authors.lastname: Courtin
authors.forename: T
authors.initials: T
authors.lastname: Dugernier
authors.forename: P
authors.initials: P
authors.lastname: Pierre
authors.forename: M
authors.initials: M
authors.lastname: Dupuis
mesh_terms: D000505:Alopecia / Q000139:chemically induced* / Q000473:pathology; D019557:Dermatitis, Perioral / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D008859:Microscopy, Polarization; D008875:Middle Aged; D011041:Poisoning / Q000473:pathology; D013280:Stomatitis / Q000139:chemically induced / Q000473:pathology; D013793:Thallium / Q000506:poisoning*
chemical_list: D013793:Thallium