Cellular immuno-competence of infected root canal contents in pathogenesis of periapical lesions.
The soluble fractions of infected root canal contents (IRCC) were collected from about 300 human extracted teeth and examined for the presence of mononuclear cell (MNC) chemotaxis and cellular immunocompetence. IRCC showed remarkable chemotactic activity for polymorphonuclear leukocytes but a weak activity for MNC. However, generation of intrinsic MNC chemotaxis and induction of cellular immunity were confirmed in rats given repeated injections of IRCC.
Ninomiya
J
J
Department of Endodontology and Periodontology, Hiroshima University School of Dentistry, Japan.
Nakanishi
K
K
Takemoto
T
T
Higashi
T
T
Ogawa
T
T
Kawaguchi
H
H
Yoshino
H
H
Hirakawa
M
M
Shiba
H
H
Hino
F
F
Shibata
K
K
Hino
T
T
D000818:Animals; D002634:Chemotaxis, Leukocyte; D017077:Culture Media, Conditioned / Q000494:pharmacology; D003788:Dental Pulp Diseases / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010483:Periapical Diseases / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar
D017077:Culture Media, Conditioned