Cutaneous sarcoidosis in a patient with Philadelphia-positive chronic myelogenous leukemia treated with interferon-alpha.
A patient with Philadelphia-positive (Ph+) chronic myelogenous leukemia (CML) was diagnosed with cutaneous sarcoidosis after treatment with interferon-alpha (IFN-alpha). Following IFN-alpha dose reduction, the skin lesions disappeared. Few cases of sarcoidosis associated with IFN treatment have been reported, and only in one patient with pre-existing CML. Our patient was unique in that (1) the sarcoidosis was induced by the IFN-alpha treatment alone, (2) it developed de novo, and (3) it was confined to the skin.
Yavorkovsky
L L
LL
Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.
Carrum
G
G
Bruce
S
S
McCarthy
P L
PL
D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000628:therapy*; D008875:Middle Aged; D010677:Philadelphia Chromosome; D012507:Sarcoidosis / Q000209:etiology*; D012871:Skin Diseases / Q000209:etiology*
D016898:Interferon-alpha