[Validation of the treatment of the neurogenic bladder in children with myelodysplasia using pikamilon].
An original Russian drug pikamilone with central (vegetotropic, vascular) and peripheral (vasodilation) mechanism of action and m-cholinolytic atropine were investigated for effect on detrusor function in the accumulation phase in 26 children with neurogenic bladder due to myelodysplasia. The detrusor function was assessed at retrograde cystometry performed before and after the drugs administration. The cystotonograms were estimated using a computer program of Relief urosystem according to the standard and additional indices. Pikamilone was found to potentiate the effects of atropine. This may be due to improvement of circulation and reduction of detrusor hypoxia. It is stated that selective chemotherapy of neurogenic bladder is uneffective. The preference should be given to combination of the drugs affecting main components of its dysfunction pathogenesis. Pikamilone should be referred to basic drugs for treatment of neurogenic bladder in spinal patients as its combination with atropine possesses a unique efficacy in restoration of the reservoir function of the bladder.
Vishnevskiĭ
E L
EL
Guseva
N B
NB
D000293:Adolescent; D001285:Atropine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D009436:Neural Tube Defects / Q000150:complications*; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid; D001285:Atropine
Obosnovanie lecheniia neĭrogennogo mochevogo puzyria u deteĭ s mielodisplazieĭ pikamilonom.