title: Plasma volume expansion with Haemaccel does not impair haemostasis during reduction mammaplasty.
abstract: OBJECTIVE
  An in vivo study under well-controlled conditions was undertaken to determine the effect of Haemaccel, a colloidal plasma volume expander, on normal haemostasis.
  
  
  METHODS
  Twenty patients, who were admitted for reduction mammaplasty, were included in this study. A standardised anaesthesia protocol was followed with all patients. Ten patients received 500 ml Haemaccel and 10 controls received 1,500 ml Ringer's lactate, a crystalloid solution. The solutions were administered intravenously during surgery over a period of 30-40 minutes. Standardised clinical observations and haematological tests were done at the following time intervals: after anaesthesia but before infusion of the plasma substitute, immediately after infusion was completed, and 20, 40 and 60 minutes after infusion.
  
  
  RESULTS
  The blood pressure, pulse rate and O2 saturation levels were not influenced by the treatment given. Haemodilution was similar for the two patient groups. The platelet count and plasma levels of fibrinogen decreased in parallel with haemodilution. Thereafter the platelet count gradually increased to pre-infusion counts at 60 minutes. The prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT) and platelet aggregation in response to adenosine diphosphate (ADP) and collagen were not affected by the plasma volume expander given. Arachidonic acid-induced aggregation decreased significantly after Ringer's lactate was given but did not change when Haemaccel was given. The bleeding time was prolonged slightly, but not significantly, from 7.4 +/- 1.6 minutes to 8.8 +/- 1.6 minutes with Ringer's lactate and from 6.9 +/- 2.0 to 9.7 +/- 3.7 minutes with Haemaccel.
  
  
  CONCLUSIONS
  We could not find any scientific evidence that Haemaccel affects haemostasis; neither does it increase bleeding relative to Ringer's lactate.
authors.affiliation: Department of Haematology, University of the Orange Free State, Bloemfontein.
authors.forename: V
authors.initials: V
authors.lastname: van Wyk
authors.forename: A
authors.initials: A
authors.lastname: Marais
authors.forename: J
authors.initials: J
authors.lastname: Diedericks
authors.forename: E
authors.initials: E
authors.lastname: van der Walt
authors.forename: L
authors.initials: L
authors.lastname: Dumas
authors.forename: P N
authors.initials: PN
authors.lastname: Badenhorst
authors.forename: K C
authors.initials: KC
authors.lastname: Alexander
authors.forename: H F
authors.initials: HF
authors.lastname: Kotzé
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007552:Isotonic Solutions / Q000494:pharmacology; D016462:Mammaplasty; D010952:Plasma Substitutes / Q000494:pharmacology*; D011097:Polygeline / Q000494:pharmacology*; D016037:Single-Blind Method
chemical_list: D007552:Isotonic Solutions; D010952:Plasma Substitutes; D011097:Polygeline