Persistent polyclonal B lymphocytosis with multiple bcl-2/IgH rearrangements: a benign disorder.
The appearance of a chronic B lymphocytosis is usually associated with the existence of an underlying monoclonal malignant condition. However, a few cases of persistent polyclonal B cell lymphocytosis (PPBL), presented in young asymptomatic women with an uneventful course, have been reported in recent years. In these PPBL cases, since the lymphocytes usually display an anomalous morphology, a false diagnosis of a neoplastic chronic lymphoproliferative syndrome can be easily made. We report a typical case of PPBL that presents multiple bcl-2 rearrangements, the typical finding of follicular lymphomas. A review of different causes of benign non neoplastic lymphocytosis with special steadiness in changes in the lymphoid subsets will be made.
Granados
E
E
Hematology Department, Hospital Universitario de La Princesa, Madrid, Spain. rgranados.ncm@ajemad.es
Llamas
P
P
Pinilla
I
I
Tomás
J F
JF
Font
P
P
Cámara
R
R
Olmeda
F
F
Arranz
R
R
Fernández-Rañada
J M
JM
D000328:Adult; D001402:B-Lymphocytes / Q000166:cytology*; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008218:Lymphocytosis / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*
D007143:Immunoglobulin Heavy Chains; D019253:Proto-Oncogene Proteins c-bcl-2