Demonstration of T-cell subsets in oral lichen planus.
The distribution of "T" cell subsets (T4 & T8) in 10 lesions of oral lichen planus was investigated using an immuno-peroxidase technique. Most of the infiltrating cells consisted of a mixture of T4 (helper/inducer) and T8 (suppressor/cytotoxic) cells, presented in the stroma with varied intensity in their distribution. The present study proved that emigration of lymphocytes, through subepithelial vessels, was not selective for the major subsets of T-cells. Subsequent migration of T8 toward the epithelium was predominant. The present study also support the view that T8 may have a role in the local destruction of the basement membrane. The immuno-regulatory status between T4 & T8 may be responsible for the different clinical forms of lichen-planus.
el-Zefzaf
E
E
Oral Medicine, Department Faculty of Dentistry, Tanta University.
Abd-el-Razzak
M
M
Ghoneim
S
S
Abu-Azma
N
N
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002465:Cell Movement; D006801:Humans; D007124:Immunoenzyme Techniques; D017676:Lichen Planus, Oral / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology*