[Adrenoceptors in the hepatic tissues in cirrhotic rats and cirrhotic patients with portal hypertension].
OBJECTIVE
To study the density of alpha 1-adrenoceptors on hepatic tissues of cirrhotic rats and cirrhotic patients with portal hypertension.


METHODS
A light autoradiography of alpha 1-adrenoreceptors on hepatic tissues of Wistar rats in the process of CC1(4)-induced cirrhosis (n = 18) and hepatitis virus B-related cirrhotic patients (n = 8) were studied.


RESULTS
The density of alpha 1-adrenoceptors on hepatic tissues (per 10,000 microns2) in rats (normal/cirrhotic early stage/cirrhotic middle stage/cirrhotic advanced stage) was 946 +/- 100/431 +/- 54/567 +/- 92/692 +/- 55 for hepatocytes, 581 +/- 90/250 +/- 87/273 +/- 92/273 +/- 88 for intrahepatic artery walls, 470 +/- 83/260 +/- 75/258 +/- 77/253 +/- 83 for intrahepatic portal walls, 362 +/- 92/229 +/- 64/218 +/- 87/212 +/- 90 for hepatic venule walls and in patients (control human beings/cirrhotic patients) it was 1255 +/- 151/583 +/- 48 for hepatocytes, 705 +/- 189/184 +/- 47 for intrahepatic artery walls 410 +/- 89/ 154 +/- 21 for intrahepatic portal walls 339 +/- 95/... ...for hepatic venule walls.


CONCLUSIONS
The density of alpha 1-adrenoceptors on various hepatic structures in cirrhotic rats and cirrhotic patients are significantly lower than that in normal rats and control human beings (P < 0.01).
Feng
H
H
Department of Surgery, People's Hospital, Beijing Medical University.
Leng
X
X
Zhang
Z
Z
D000368:Aged; D000818:Animals; D001345:Autoradiography; D002252:Carbon Tetrachloride Poisoning; D005260:Female; D006499:Hepatic Artery / Q000378:metabolism; D006503:Hepatic Veins / Q000378:metabolism; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*
D018340:Receptors, Adrenergic, alpha-1