Casein peptide release and passage to the blood in humans during digestion of milk or yogurt.
In adult humans, after milk or yogurt ingestion, many peptides derived from alpha s1-, beta- or kappa-caseins were detected in stomach, including the kappa-caseinoglycopeptide, an inhibitor of platelet aggregation. Smaller peptides derived from casein and lactoferrin were recovered from duodenum. Two long peptides, the kappa-caseinoglycopeptide and the N-terminal peptide of alpha s1-casein, were absorbed and detected in plasma. These results support the concept that food-born peptides could have physiological activities in man.
Chabance
B
B
CNRS-URA 1188, Université de Paris V, France.
Marteau
P
P
Rambaud
J C
JC
Migliore-Samour
D
D
Boynard
M
M
Perrotin
P
P
Guillet
R
R
Jollès
P
P
Fiat
A M
AM
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D002364:Caseins / Q000097:blood* / Q000378:metabolism* / Q000494:pharmacology; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004063:Digestion; D004386:Duodenum / Q000378:metabolism; D005260:Female; D005343:Fibrinolytic Agents / Q000097:blood* / Q000494:pharmacology; D005753:Gastric Mucosa / Q000378:metabolism; D006020:Glycopeptides / Q000097:blood* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008892:Milk / Q000378:metabolism*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000097:blood* / Q000494:pharmacology; D010455:Peptides / Q000097:blood; D010974:Platelet Aggregation; D015014:Yogurt
D002364:Caseins; D005343:Fibrinolytic Agents; D006020:Glycopeptides; D010446:Peptide Fragments; D010455:Peptides; C065989:caseinomacropeptide; C094310:kappa-caseinoglycopeptide