title: Synthesis of DHPA analogs and their inhibitory activities of human recombinant S-adenosyl-L-homocysteine hydrolase.
abstract: We report syntheses of DHPA analogs, e.g., 9-(3-formyl-2,3-dihydroxypropyl)adenine (FDHPA) and 9-(3-formyl-2,3-dihydroxypropyl)hypoxanthine (FDHPI). Among these DHPA analogs, FDHPA behaved as an irreversible inactivator of human recombinant SAH hydrolase.
authors.affiliation: Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kitade
authors.forename: M
authors.initials: M
authors.lastname: Nakanishi
authors.forename: A
authors.initials: A
authors.lastname: Hosoya
authors.forename: A
authors.initials: A
authors.lastname: Hiraoka
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Gotoh
authors.forename: C
authors.initials: C
authors.lastname: Yatome
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006867:Hydrolases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008113:Liver Neoplasms; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; C016391:9-(2,3-dihydroxypropyl)adenine; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D000225:Adenine