Melanocortin-4 receptor mRNA expression in the developing autonomic and central nervous systems.
MC4-R mRNA expression was investigated in fetal rats (E14-E20) using in situ hybridisation. The autonomic nervous system showed the highest levels of MC4-R mRNA expression. In the spinal cord, dense signal was seen over the future intermediolateral cell column and dorsal horn. In the brain, MC4-R was expressed by E14 in diencephalon neuroepithelia, telencephalon, lamina terminalis and spinal trigeminal nucleus and was expressed by E19 throughout many regions of the brain.
Mountjoy
K G
KG
Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, Auckland 1, New Zealand. kmountjoy@auckland.ac.nz
Wild
J M
JM
D000818:Animals; D001341:Autonomic Nervous System / Q000254:growth & development* / Q000378:metabolism*; D001921:Brain / Q000254:growth & development; D002490:Central Nervous System / Q000254:growth & development* / Q000378:metabolism*; D005260:Female; D019204:GTP-Binding Proteins / Q000096:biosynthesis / Q000235:genetics; D017403:In Situ Hybridization; D011247:Pregnancy; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D044105:Receptor, Melanocortin, Type 4; D018000:Receptors, Peptide / Q000096:biosynthesis*; D013116:Spinal Cord / Q000254:growth & development / Q000378:metabolism
D012333:RNA, Messenger; D044105:Receptor, Melanocortin, Type 4; D018000:Receptors, Peptide; D011333:Pro-Opiomelanocortin; D019204:GTP-Binding Proteins