title: Obliteration of the frontal sinus cavity with bioactive glass.
abstract: BACKGROUND
  Bioactive glass (BG) is a glass ceramic material. It has been used as surgical bone replacement material in ear and oral surgery, orthopedics, and dentistry.
  
  
  METHODS
  Bioactive glass was used as obliteration material in a series of osteoplastic frontal sinus operations on 10 patients suffering from chronic frontal sinusitis, which other, more-conservative treatment modalities had failed to cure.
  
  
  RESULTS
  Bioactive glass is easy to handle, and complete obliteration of all sinusal recesses and excavations is easily achieved. No adverse effects of the implant material have been seen over a mean follow-up period of 5.0 years. One patient with a local recurrent infection in the outer table of the sinus was reoperated on 5 months after primary surgery. Repeated postoperative computed tomographic scans analyzed by digital region-of-interest (ROI) selection showed no remarkable changes in the frontal sinus cavities but a slight, yearly decrease in the density of the occlusion material. Laboratory monitoring of patients and histopathologic examination of two postoperative biopsy specimens indicated that the material is well tolerated and stable.
  
  
  CONCLUSIONS
  Bioactive glass is a promising and well-tolerated bone graft suitable for osteoplastic frontal sinus operations. Total accurate obliteration of the sinus is achieved with different sizes of granules and blocks. The results of the obliteration are maintained owing to the stability of the material.
authors.affiliation: Department of Otolaryngology, Turku University Central Hospital, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Peltola
authors.forename: J
authors.initials: J
authors.lastname: Suonpää
authors.forename: K
authors.initials: K
authors.lastname: Aitasalo
authors.forename: M
authors.initials: M
authors.lastname: Varpula
authors.forename: A
authors.initials: A
authors.lastname: Yli-Urpo
authors.forename: R P
authors.initials: RP
authors.lastname: Happonen
mesh_terms: D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002908:Chronic Disease; D005260:Female; D015522:Frontal Sinusitis / Q000601:surgery*; D005898:Glass; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes