Colicin E5 as a new type of cytotoxin, which cleaves a specific group of tRNAs.
The C-terminal active domain of colicin E5 has a novel ribonuclease activity which specifically cleaves queuine-containing tRNAs. Colicin E5 is a new type cytotoxin targeting a group of tRNAs.
Masaki
H
H
Department of Biotechnology, University of Tokyo, Japan.
Ogawa
T
T
Tomita
K
K
Ueda
T
T
Watanabe
K
K
Uozumi
T
T
D001665:Binding Sites; D003087:Colicins / Q000737:chemistry / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D006868:Hydrolysis; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism; D012329:RNA, Bacterial / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D013379:Substrate Specificity
D003087:Colicins; D010446:Peptide Fragments; D012329:RNA, Bacterial; D012343:RNA, Transfer