title: X-ray analysis of DNA dodecamer containing 2'-deoxy-N6-methoxyadenosine.
abstract: Oxyamines have been known as a mutagen which attacks amino groups of DNA bases. It is expected that the modified adenine derivative has a tautomer which can form a stable base pair not only with thymine but also with cytosine. For establishing such tautomerization mutagenesis, we have solved a crystal structure of DNA dodecamer containing 2'-deoxy-N6-methoxyadenosine. It is shown that the N6-methoxyadenine takes a imino form to form a Watson-Crick type pairing with cytosine in the DNA duplex.
authors.affiliation: Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Chatake
authors.forename: T
authors.initials: T
authors.lastname: Toyoda
authors.forename: M
authors.initials: M
authors.lastname: Tsunoda
authors.forename: T
authors.initials: T
authors.lastname: Sunami
authors.forename: A
authors.initials: A
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Ueno
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
authors.forename: A
authors.initials: A
authors.lastname: Takenaka
mesh_terms: D001482:Base Composition; D001483:Base Sequence; D018360:Crystallography, X-Ray / Q000379:methods; D004247:DNA / Q000737:chemistry*; D003839:Deoxyadenosines; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C113084:2'-deoxy-N(6)-methoxyadenosine; D003839:Deoxyadenosines; D009838:Oligodeoxyribonucleotides; D004247:DNA