[Dynamics of spontaneous beating of cardiomyocytes in vitro depend on the number of involved cells].
The dynamics of cardiomyocyte spontaneous beatings with fractal dimension calculation was studied. It was shown that isolated single cardiomyocyte beats stochastically, but when a number of cells synchronized a significant changes in the dynamics appear: deterministic chaos could be detected. Several reasons are discussed as a possible explanation of such a behavior: the effect of system volume increasing and specific influence of gap-junctions on the rhythm formation.
Pzharskiĭ
T R
TR
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Sorokin
A A
AA
Rochev
Iu A
IuA
Gavriliuk
B K
BK
Chaĭlakhian
L M
LM
D000818:Animals; D002452:Cell Count; D006321:Heart / Q000502:physiology*; D008954:Models, Biological; D008962:Models, Theoretical; D009200:Myocardial Contraction; D009206:Myocardium / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar
Izmenenie dinamiki sokrashcheniĭ kardiomiotsitov in vitro pri uvelichenii chisla vzaimodeĭstvuiushchikh kletok.