Multiple epigenetic events regulate mating-type switching of fission yeast.
Two epigenetic events at mat1, one of which is DNA strand specific, are required to initiate recombination during mating-type switching. The third, a chromosomally borne imprinted event at the mat2/3 interval regulates silencing and directionality of switching, and prohibits interchromosomal recombination. We speculate that the unit of inheritance in the mat2/3 interval is both DNA plus its associated chromatin structure. Such a control is likely to be essential in maintaining particular states of gene expression during development.
Klar
A J
AJ
National Cancer Institute-Frederick Cancer Research, Frederick, MD 21702-1201, USA.
Ivanova
A V
AV
Dalgaard
J Z
JZ
Bonaduce
M J
MJ
Grewal
S I
SI
D000818:Animals; D015825:Chromosomes, Fungal; D004271:DNA, Fungal; D005785:Gene Conversion; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D049770:Genes, Mating Type, Fungal; D018392:Genomic Imprinting; D009363:Neoplasm Proteins / Q000235:genetics; D011995:Recombination, Genetic; D012568:Schizosaccharomyces / Q000235:genetics*
D004271:DNA, Fungal; D009363:Neoplasm Proteins