[A study of 5-fluorouracil on bovine trabecular meshwork cells in vitro].
OBJECTIVE
To determine whether the clinical use of 5-fluorouracil (5-FU) may have any toxic effects on trabecular meshwork cells.


METHODS
Bovine trabecular meshwork (BTM) cells were cultured in vitro. The effects of 5-FU on BTM cells concerning cellular morphology, ultrastructure, vitality and phagocytosis were observed.


RESULTS
The safe dosage of 5-FU on BTM cell was 1 x 10-6g.ml-1.


CONCLUSIONS
Based on the pharmacokinetic data in the rabbit anterior chamber, it is suggested that the 5-FU dosage of conventional use cause no injury to human trabecular meshwork cells.
Jiang
F
F
Department of Ophthalmology, Union Hospital, Tongji Medical University, Wuhan.
Wei
H
H
Lü
Y
Y
D000818:Animals; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005472:Fluorouracil / Q000633:toxicity*; D010587:Phagocytosis / Q000187:drug effects; D014129:Trabecular Meshwork / Q000166:cytology / Q000187:drug effects*
D005472:Fluorouracil