title: The alterations in the activity of amylase and its salivary isoenzyme in the serum of patients with ovarian carcinoma, submitted to radiotherapy.
abstract: Total activity of alpha-amylase and its salivary isoenzyme in the serum of patients with ovarian carcinoma of various types were evaluated before radiotherapy, in the middle of radiotherapy period, in the last day and 2 months after radiotherapy. Before radiotherapy the activity of these enzymes were significantly higher in patients with ovarian serous cystadenocarcinoma. It was found that irradiation resulted in a decrease of both total amylase activity and its salivary isoenzyme in the serum. The proportional participation of salivary isoenzymes in total amylase activity was normalized. It is suggested that the assay of salivary alpha-amylase activity may be useful in the evaluation of radiotherapy effectiveness.
authors.affiliation: Department of Clinical Laboratory Diagnostics, Medical Academy of Białystok.
authors.forename: I
authors.initials: I
authors.lastname: Zakrzewska
authors.forename: M
authors.initials: M
authors.lastname: Pietryńczak
mesh_terms: D000328:Adult; D000368:Aged; D000681:Amylases / Q000097:blood / Q000528:radiation effects; D002277:Carcinoma / Q000201:enzymology* / Q000532:radiotherapy / Q000601:surgery; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D018284:Cystadenocarcinoma, Serous / Q000201:enzymology* / Q000532:radiotherapy / Q000601:surgery; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000528:radiation effects*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000532:radiotherapy / Q000601:surgery; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012471:Salivary Proteins and Peptides / Q000097:blood / Q000528:radiation effects*; D000516:alpha-Amylases / Q000097:blood / Q000528:radiation effects*
chemical_list: D003037:Cobalt Radioisotopes; D007527:Isoenzymes; D019275:Radiopharmaceuticals; D012471:Salivary Proteins and Peptides; D000681:Amylases; D000516:alpha-Amylases