title: The search for orally active medications through combinatorial chemistry.
abstract: The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.
authors.affiliation: Department of Medicinal Chemistry, Kansas University, Lawrence 66045-2506, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Fecik
authors.forename: K E
authors.initials: KE
authors.lastname: Frank
authors.forename: E J
authors.initials: EJ
authors.lastname: Gentry
authors.forename: S R
authors.initials: SR
authors.lastname: Menon
authors.forename: L A
authors.initials: LA
authors.lastname: Mitscher
authors.forename: H
authors.initials: H
authors.lastname: Telikepalli
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D010599:Pharmacokinetics; D013329:Structure-Activity Relationship