title: Endocrine therapy of prostate cancer.
abstract: Endocrine therapy is effective treatment for patients with metastatic prostate cancer. Most patients will benefit from androgen withdrawal in terms of symptomatic relief and delay in progression of diseases. It does not, however, cure patients with metastatic prostate cancer. This finding emphasizes the need for the development of effective nonendocrine therapies.
authors.affiliation: Department of Urology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1094, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Bare
authors.forename: F M
authors.initials: FM
authors.lastname: Torti
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D000616:Aminoglutethimide / Q000627:therapeutic use; D000726:Androgen Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008297:Male; D009362:Neoplasm Metastasis; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D009919:Orchiectomy; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D011966:Receptors, LHRH / Q000187:drug effects; D013148:Spironolactone / Q000627:therapeutic use; D016019:Survival Analysis; D013739:Testosterone
chemical_list: D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal; D004791:Enzyme Inhibitors; D004967:Estrogens; D011966:Receptors, LHRH; D000616:Aminoglutethimide; D013148:Spironolactone; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007654:Ketoconazole