First-pass versus second-pass parsing processes in a Wernicke's and a Broca's aphasic: electrophysiological evidence for a double dissociation.
The present paper is a first attempt to integrate the classical brain lesion behavioral impairment approach of functional neuroanatomy and the electrophysiological brain mapping approach in the domain of syntactic processing. In a group of normal age-matched controls we identified three electrophysiological components previously observed in correlation with language comprehension processes: an early left anterior negativity normally seen in correlation with syntactic first-pass parsing processes (ELAN), a centroparietal negativity seen in correlation with processes of lexical-semantic integration (N400), and a late centroparietal positivity observed in correlation with secondary syntactic processes of reanalysis and repair (P600). The early left anterior negativity was absent in a patient with an extended lesion in the anterior part of the left hemisphere sparing the temporal lobe, although the late centroparietal positivity and the centroparietal N400 were present. In a patient with a left temporal-parietal lesion the early left anterior negativity was found to be present, whereas the N400 component was absent. These findings suggest that first-pass parsing and secondary processes are subserved by distinct brain systems.
Friederici
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Max-Planck-Institute of Cognitive Neuroscience, Leipzig, Germany. angelafr@cns.mpg.de
Hahne
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von Cramon
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DY
D000328:Adult; D000704:Analysis of Variance; D001039:Aphasia, Broca / Q000150:complications* / Q000175:diagnosis*; D001041:Aphasia, Wernicke / Q000150:complications* / Q000175:diagnosis*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D004569:Electroencephalography; D004585:Electrooculography; D005072:Evoked Potentials, Auditory; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed