title: Pleomorphic fibroma of the eyelid.
abstract: BACKGROUND
  This report describes the pathology of an unusual variant of fibroma of the eyelid. The soft ovoid tumour was excised from the centre of the left lower lid in an 84-year-old patient had been growing slowly for several years.
  
  
  METHODS
  The tumour was studied by conventional histology, immunohistochemistry and electron microscopy.
  
  
  RESULTS
  The tumor was formed by fibroblasts of spindle and multinucleate type, and the collagenous stroma contained mast cells and blood vessels which exhibited minor inflammatory changes. With the immunohistochemical methods the only positive marker was for vimentin.
  
  
  CONCLUSIONS
  On morphological grounds it was possible to distinguish this extremely rare tumour from other mesenchymal tumours. The presence of distinctive multinucleate giant cells makes the term pleomorphic fibroma an appropriate name for this type of lesion.
authors.affiliation: Department of Pathology, University of Glasgow, Western Infirmary, UK.
authors.forename: T
authors.initials: T
authors.lastname: Sandinha
authors.forename: W R
authors.initials: WR
authors.lastname: Lee
authors.forename: R
authors.initials: R
authors.lastname: Reid
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005142:Eyelid Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D005347:Fibroblasts / Q000648:ultrastructure; D005350:Fibroma / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008407:Mast Cells / Q000648:ultrastructure; D014746:Vimentin / Q000378:metabolism
chemical_list: D014746:Vimentin