Transcriptional regulation during B cell development.
Information is increasingly available concerning the molecular events that occur during primary and antigen-dependent stages of B cell development. In this review the roles of transcription factors and coactivators are discussed with respect to changes in expression patterns of various genes during B cell development. Transcriptional regulation is also discussed in the context of developmentally regulated immunoglobulin gene V(D)J recombination, somatic hypermutation, and isotype switch recombination.
Henderson
A
A
Department of Veterinary Science, Pennsylvania State University, University Park 16802, USA. KLC1@columbia.edu
Calame
K
K
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D006801:Humans; D014158:Transcription, Genetic / Q000502:physiology*