Expression of human cytosolic thymidine kinase in Escherichia coli. A bacterial whole cell system for screening of potential antiproliferative nucleoside analogs.
Wang
J
J
Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, Biomedical Center, Uppsala, Sweden.
Neuhard
J
J
Eriksson
S
S
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D003001:Cloning, Molecular; D003600:Cytosol / Q000201:enzymology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D006801:Humans; D009705:Nucleosides / Q000494:pharmacology; D013936:Thymidine / Q000031:analogs & derivatives / Q000494:pharmacology; D013937:Thymidine Kinase / Q000096:biosynthesis*
D000964:Antimetabolites, Antineoplastic; D009705:Nucleosides; D013937:Thymidine Kinase; C092717:thymidine kinase 1; D013936:Thymidine