Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat.
The aim of the present work was to assess the capacity of Spirulina maxima to prevent fatty liver development induced in rats by an intraperitoneal single dose (1 ml/kg) of carbon tetrachloride. Liver and serum lipids were quantified two or four days after treatment with this agent. Liver lipid concentration did not differ in rats fed on a purified diet with or without Spirulina. However, after carbon tetrachloride treatment, liver triacylglycerols were significantly lower in rats fed on a diet with Spirulina 5% than in rats without Spirulina in their diet (P < 0.05). Furthermore, the increased liver cholesterol values, induced by carbon tetrachloride treatment, were not observed in rats that received Spirulina. These results support the potential hepatoprotective role of Spirulina.
Torres-Durán
P V
PV
Departamento de Bioquímica, UNAM, México, D.F., Mexico.
Miranda-Zamora
R
R
Paredes-Carbajal
M C
MC
Mascher
D
D
Díaz-Zagoya
J C
JC
Juárez-Oropeza
M A
MA
D000208:Acute Disease; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D000458:Cyanobacteria; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000139:chemically induced / Q000517:prevention & control*; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D008055:Lipids; D002251:Carbon Tetrachloride