[Experimental study of adoptive immunotherapy for adenoid cystic carcinoma of the salivary gland].
To study adoptive immunotherapy for adenoid cystic carcinoma of the salivary gland, we evaluate the influence of TNF-alpha or IFN-gamma on the activity of LAK cells when they acted at different stages of LAK cells killing target cells. The results in vitro experiment showed that ACC-2 was susceptible to LAK cytotoxicity. Both TNF-alpha and IFN-gamma could be an enhancer to augment IL-2-induced LAK cytotoxity against ACC-2, TNF-alpha should be used to induce LAK cells, but IFN-gamma is suitable to pretreat target cells ACC-2.
Li
X
X
Department of Stomatology, Changhai Hospital.
Zhou
Z
Z
Peng
Y
Y
D003528:Carcinoma, Adenoid Cystic / Q000473:pathology / Q000628:therapy*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D016219:Immunotherapy, Adoptive; D007371:Interferon-gamma / Q000494:pharmacology; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000628:therapy*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma