Mechanistic investigation of photoreduction of 5-bromouracil-containing oligomers.
It was found that photoreduction of 5-bromouracil (BrU) occurs at 5'-ATBrU-3' sequence more efficiently than 5'-ABrU-3'. We introduced 5'-GG-3' sequence at the 5'-side of 5'-ATBrU-3' sequence and 5'-ABrU-3' sequence and investigated their photoreduction. As a result, dIz, an oxidation product originated from guanine cation radical, was detected.
Fujimoto
K
K
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Japan.
Ishihara
S
S
Saito
I
I
D001483:Base Sequence; D001976:Bromouracil; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000528:radiation effects; D010084:Oxidation-Reduction; D010777:Photochemistry; D011789:Quantum Theory; D013329:Structure-Activity Relationship
D009838:Oligodeoxyribonucleotides; D001976:Bromouracil