title: Force acting on spheres adhered to a vessel wall.
abstract: To evaluate the force and torque acting on leukocytes attached to the vessel wall, we numerically study the flow field around the leukocytes by using rigid spherical particles adhered to the wall of a circular cylindrical tube as a model of adherent leukocytes. The adherent particles are assumed to be placed regularly in the flow direction with equal spacings, in one row or two rows. The flow field of the suspending fluid is analyzed by a finite element method applied to the Stokes equations, and the drag force and torque acting on each particle, as well as the apparent viscosity, are evaluated as a function of the particle to tube diameter ratio and the particle arrangements. For two-row arrangements of adhered particles where neighboring particles are placed alternately on opposite sides of the vessel, the drag and the torque exerted on each particle are higher than those for single-row arrangements, for constant particle to tube diameter ratio and axial spacing between neighboring particles. This is enhanced for larger particles and smaller axial spacings. The apparent viscosity of the flow through vessels with adhered particles is found to be significantly higher than that without adhered particles or when the particles are freely floating through the vessels.
authors.affiliation: Faculty of Engineering, Kansai University Suita, Osaka, Japan. sekim@gep.kansai-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Sugihara-Seki
authors.forename: R
authors.initials: R
authors.lastname: Skalak
mesh_terms: D001809:Blood Viscosity; D002448:Cell Adhesion; D004730:Endothelium, Vascular; D018056:Hemorheology; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D008954:Models, Biological; D012039:Regional Blood Flow; D019415:Torque