Adaptation in cyclic AMP signalling processes: a central role for cyclic AMP phosphodiesterases.
Cyclic AMP has provided the paradigm for the second messenger concept. Recent evidence has identified a complex array of isoforms of the enzymes involved in generation, destroying and transmitting the effects of this second messenger. These proteins provide a sophisticated system for organising cAMP signal transduction in specific intracellular compartments; for allowing integration with other signalling systems and for controlling the kinetics and hence reaction characteristics of cAMP signal transduction.
Houslay
M D
MD
Department of Biochemistry and Molecular Biology L.B.L.S., University of Glasgow, Scotland, UK.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000502:physiology*; D000222:Adaptation, Physiological; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases