title: Subclinical cerebral lesion accumulation on serial magnetic resonance imaging (MRI) in patients with hypertension: risk factors.
abstract: OBJECTIVE
  We investigated the occurrence in hypertensive patients of new subclinical changes in the brain by serial magnetic resonance imaging (MRI).
  
  
  METHODS
  MRI was performed serially in 98 hypertensive subjects without neurologic deficits at least once a year for 3 years. All received antihypertensive medicines Blood pressure, serum lipids, diabetes mellitus, body mass index (BMI), and other clinical factors were correlated with results.
  
  
  RESULTS
  Seventy-nine patients had unchanged MRI findings, while 19 developed new lesions (silent lacunar infarct and etat criblé in 3, silent lacunar infarct in 9, and etat criblé in 7). Follow-up systolic blood pressures were significantly higher than individual baselines in the unchanged group, while the follow-up diastolic blood pressures in the new lesion group were significantly lower than in the unchanged group. BMI was significantly lower in the new lesion group. Follow-up HbA1c levels in both groups were significantly higher than at baseline. Diabetes mellitus was significantly more frequent in the new lesion group than in the unchanged group. No significant differences were apparent in serum lipids level, prescribed antihypertensive medications, and other potential risk factors.
  
  
  CONCLUSIONS
  New subclinical MRI changes in hypertensive subjects occurred relatively frequently (19 of 98 subjects, or 19.4%). An excessive fall in diastolic blood pressure, diabetes mellitus, and low BMI emerged as candidate risk factors for these changes.
authors.affiliation: Department of Neurology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shintani
authors.forename: T
authors.initials: T
authors.lastname: Shiigai
authors.forename: T
authors.initials: T
authors.lastname: Arinami
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D015992:Body Mass Index; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology; D048909:Diabetes Complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents; D008055:Lipids