[Risk factors and the molecular cellular mechanisms of a protracted course in pneumonia].
OBJECTIVE
Investigation of risk factors and molecular-cellular. mechanisms of development of lingering pneumonia (LP).


METHODS
Examination covered 202 patients with acute pneumonia and 199 patients with LP.


RESULTS
LP was characterized by deeper suppression of immunity, restructuring of the lipid bilayer, changed microviscosity and enzymic activity of red cell membranes as a result of infectious-toxic factor, activation of lipid peroxidation, suppression of the antioxidant defense.


CONCLUSIONS
The findings contribute to design of more detailed principles of pathogenetic therapy and prevention of LP.
Dandyshev
S Iu
SIu
D000208:Acute Disease; D002908:Chronic Disease; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000737:chemistry* / Q000201:enzymology; D006801:Humans; D015227:Lipid Peroxidation; D008563:Membrane Lipids / Q000097:blood; D011014:Pneumonia / Q000097:blood* / Q000276:immunology; D012307:Risk Factors; D013113:Spin Labels; D013997:Time Factors; D014783:Viscosity
D008563:Membrane Lipids; D013113:Spin Labels
Faktory riska i molekuliarno-kletochnye mekhanizmy zatiazhnogo techeniia pnevmonii.