[Morphine antibodies in the mechanisms of morphine resistance, morphine tolerance and of the action of an antagonist].
It was found that the absence of the analgesic effect of morphine, as determined by the tail-flick test, in morphine-resistant and morphine-tolerant rats, as well as in naloxane blockade of morphine analgesia in morphine-sensitive rats was attended with a four- to eight-fold increase in morphine antibodies in the plasma, as determined by the ELISA method. It is suggested that a pharmacokinetic factor mediated through immune reactions of morphine antibodies formation is one of the mechanisms of such conditions.
Kaliuzhnyĭ
L V
LV
Department of Higher Nervous Activity, Lomonsov Moscow State University, Russia.
Litvinova
S V
SV
Kaliuzhnyĭ
A L
AL
Aristova
V V
VV
Gruden'
M A
MA
Kozlov
A Iu
AIu
Torgovanova
G V
GV
Fedoseeva
O V
OV
D000375:Aging / Q000187:drug effects / Q000276:immunology; D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000187:drug effects* / Q000494:pharmacology; D004351:Drug Resistance; D004361:Drug Tolerance; D006358:Hot Temperature; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000276:immunology* / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013623:Tail
D001323:Autoantibodies; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine
Antitela k morfinu v mekhanizmakh morfinnoĭ rezistentnosti, morfinnoĭ tolerantnosti i deĭstviia antagonista.