title: The relation of fasting insulin to blood pressure in a multiethnic population: the Miami Community Health Study.
abstract: OBJECTIVE
  The aim of this study was to examine the associations among fasting insulin, adiposity, waist girth, and blood pressure among a nondiabetic multiethnic population.
  
  
  METHODS
  A cross-sectional study was performed among 25-44-year-old African-Americans (n = 159), Cuban-Americans (n = 128), and non-Hispanic whites (n = 207) selected from Dade County, Florida. Fasting insulin levels were correlated with resting blood pressure level within each ethnic group. The separate effects of percentage body fat and waist girth on the association between blood pressure and insulin were analyzed in multiple linear regression and analysis of covariance.
  
  
  RESULTS
  Fasting insulin was positively associated with systolic (r = 0.26-0.39; P < 0.01) and diastolic blood pressure (r = 0.19-0.30; P = 0.10 to P < 0.001) among women of all ethnic groups and among non-Hispanic white men (r = 0.27; P < 0.05). Stepwise linear regression analyses revealed statistically significant associations between systolic and diastolic blood pressure and fasting insulin level in non-Hispanic whites independent of other covariates, including sex and percentage body fat (P < 0.001). Fasting insulin was also independently and significantly related to systolic blood pressure among African-Americans (P = 0.02). Among Cuban-Americans, sex and percentage body fat were the main correlates of blood pressure level. Analysis of covariance revealed a relationship between insulin and blood pressure that was independent of waist girth among men and women.
  
  
  CONCLUSIONS
  Fasting insulin level and blood pressure were positively associated among African-Americans and non-Hispanic whites. This association was not entirely due to the common association with percentage body fat or waist girth.
authors.affiliation: University of Miami School of Medicine, Department of Epidemiology and Public Health, FL, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Donahue
authors.forename: R J
authors.initials: RJ
authors.lastname: Prineas
authors.forename: J A
authors.initials: JA
authors.lastname: Bean
authors.forename: R A
authors.initials: RA
authors.lastname: deCarlo Donahue
authors.forename: R B
authors.initials: RB
authors.lastname: Goldberg
authors.forename: J S
authors.initials: JS
authors.lastname: Skyler
authors.forename: N
authors.initials: N
authors.lastname: Schneiderman
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D000704:Analysis of Variance; D044383:Black People; D001794:Blood Pressure; D001823:Body Composition; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005215:Fasting; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D044465:White People; D001741:Black or African American
chemical_list: D007328:Insulin