Is parathyroid hormone a therapeutic option for osteoporosis? A review of the clinical evidence.
Most of the data on the anabolic effect of PTH have been obtained with hPTH(1-34). Studies have shown a marked increment in spinal bone mass. Most recently we have shown that PTH and estrogen can be given together where there is increased total bone mineral and no loss of bone at any skeletal site. We have also shown the first reduction in vertebral deformity incidence due to PTH treatment.
Cosman
F
F
Clinical Research Center, Helen Hayes Hospital, West Haverstraw, New York 10993, USA.
Lindsay
R
R
D000818:Animals; D004967:Estrogens / Q000627:therapeutic use; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000378:metabolism / Q000627:therapeutic use*
D004967:Estrogens; D010281:Parathyroid Hormone