title: Nitric oxide-mediated cGMP production in the islands of Calleja in the rat.
abstract: cGMP-immunostaining in the islands of Calleja (ICj) in slices incubated in vitro partially co-localized with nitric oxide synthase (NOS) inside the ICj. No cGMP-immunostaining was found outside the ICj in unstimulated slices, whereas the NO-donor sodium nitroprusside (SNP) stimulated cGMP in cells and fibers bordering on the ICj. These findings show an ongoing NO synthesis in in vitro slices and suggest a relatively restricted diffusion range for endogenously synthesized NO.
authors.affiliation: European Graduate School of Neuroscience (EURON), Maastricht University, Department of Psychiatry and Neuropsychology, Netherlands. j.devente@np.unimaas.nl
authors.forename: J
authors.initials: J
authors.lastname: de Vente
authors.forename: D A
authors.initials: DA
authors.lastname: Hopkins
authors.forename: M
authors.initials: M
authors.lastname: Markerink-van Ittersum
authors.forename: H W
authors.initials: HW
authors.lastname: Steinbusch
mesh_terms: D000818:Animals; D006152:Cyclic GMP / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology; D009830:Olfactory Bulb / Q000378:metabolism*; D010069:Oxadiazoles / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D014018:Tissue Distribution
chemical_list: C095284:1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; D004791:Enzyme Inhibitors; D010069:Oxadiazoles; D011810:Quinoxalines; D009599:Nitroprusside; D009569:Nitric Oxide; D006162:Guanylate Cyclase; D006152:Cyclic GMP; D019331:NG-Nitroarginine Methyl Ester