Role of integrins in enterocyte migration.
1. Enterocyte motility depends critically on cell-matrix interactions. Although still incompletely understood, these appear critically dependent upon integrin-mediated cell adhesion. 2. In addition to providing a mechanism for cell adhesion and traction, the integrins are likely to serve as true receptors for the matrix across which cell motility occurs, initiating signals by both mechanical and chemical means that alter cell phenotype and proliferation as well as cell motility. 3. Sound rationale now exists to postulate that soluble growth factors within the extracellular milieu regulate intestinal mucosal healing not only directly but also indirectly by modulating integrin expression and organization.
Basson
M D
MD
Department of Surgery, Yale University School of Medicine and the Connecticut Veterans Affairs Health Care System, New Haven 06520-8062, USA. BASSON.MARC_D+@WEST-HAVEN.VA.GOV
D002448:Cell Adhesion; D002465:Cell Movement; D004848:Epithelium / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D007413:Intestinal Mucosa / Q000473:pathology / Q000502:physiology*
D006133:Growth Substances; D016023:Integrins