title: Tubulopapillary hidradenoma-like tumor of the mandible: clinicopathologic and immunohistochemical features.
abstract: Tubulopapillary hidradenoma is a benign sweat gland tumor that appears as a well-defined, superficially located dermal nodule. It combines ductal as well as apocrine and eccrine glandular differentiation. Microscopically, the tumor is composed of tubular structures that characteristically show intraluminal non-villous papillary projections and a peripheral myoepithelial cell layer. A tumor that is histologically and immunohistochemically identical to tubulopapillary hidradenoma occurred in the mandible of a 73-year-old man and resulted in considerable diagnostic difficulty. The neoplasm developed in a mandibular cyst and recurred 5 years after initial enucleation. This is the first report of a central (intraosseous) sweat gland adenoma of the mandible. The differential diagnosis and possible histogenesis are discussed.
authors.affiliation: Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: El-Mofty
authors.forename: M A
authors.initials: MA
authors.lastname: Hurt
authors.forename: D J
authors.initials: DJ
authors.lastname: Santa Cruz
mesh_terms: D000199:Actins / Q000032:analysis; D006607:Adenoma, Sweat Gland / Q000209:etiology / Q000473:pathology*; D000368:Aged; D001050:Apocrine Glands / Q000473:pathology; D001845:Bone Cysts / Q000473:pathology; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003593:Cytoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004439:Eccrine Glands / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D008339:Mandibular Neoplasms / Q000209:etiology / Q000473:pathology*; D009130:Muscle, Smooth / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D014746:Vimentin / Q000032:analysis
chemical_list: D000199:Actins; D014746:Vimentin; D007633:Keratins