Regulation of the Sex combs reduced gene in Drosophila.
The Sex combs reduced gene of the Antennapedia complex specifics the identities of the anterior thoracic and posterior head segments, including the primordium of the larval salivary gland. The Sex combs reduced transcription unit spans over 30 kb of genomic DNA, with another 40 kb of upstream cis-regulatory sequences. The pattern of Sex combs reduced transcription is set in the early embryo by the segmentation genes and is then maintained by two competing sets of proteins, the Polycomb group and the trithorax group. One of the trithorax group genes required for activation, the brahma gene, encodes an evolutionarily conserved DNA-stimulated ATPase that is part of a large protein complex. This complex facilitates the action of sequence-specific, DNA-binding proteins in regulating target genes, possibly by altering chromatin structure.
Kennison
J A
JA
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2785, USA. jkl5o@nih.gov
Vázquez
M
M
Brizuela
B J
BJ
D000818:Animals; D018797:Cell Cycle Proteins; D004330:Drosophila; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D019476:Insect Proteins / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; C084011:SMARCA2 protein, human; C059627:Scr protein, Drosophila; D015534:Trans-Activators; D014157:Transcription Factors; C086469:brm protein, Drosophila