title: Post-infection fatigue syndrome following Q fever.
abstract: In 1989, 147 individuals in the West Midlands, UK, were infected with Q fever. Five years later, following anecdotal reports of fatigue, we used a questionnaire-based case-control study to determine the prevalence of chronic fatigue syndrome symptoms in this group. Replies from 71 patients were compared with those from 142 age- and sex-matched controls. Increased sweating (52.9% vs. 31.6%, p = 0.006), breathlessness (50.7% vs. 30.6%, p = 0.006), blurred vision (34.3% vs. 17.8%, p = 0.016) and undue tiredness (68.7% vs. 51.5%, p = 0.03) were found in controls compared to cases. These findings were similar to those in Australian abbatoir workers occupationally exposed to Q fever. CDC criteria for chronic fatigue syndrome were fulfilled by 42.3% of cases and 26% of controls. Using visual analogue scores, symptoms were more severe in cases than in controls. Our findings support the existence of a chronic fatigue state following acute Q fever, in a group of patients exposed just once to the organism, and in circumstances free of such confounding factors as lawsuits over compensation.
authors.affiliation: Department of Respiratory Medicine, Heartlands Hospital, Birmingham, UK.
authors.forename: J G
authors.initials: JG
authors.lastname: Ayres
authors.forename: N
authors.initials: N
authors.lastname: Flint
authors.forename: E G
authors.initials: EG
authors.lastname: Smith
authors.forename: W S
authors.initials: WS
authors.lastname: Tunnicliffe
authors.forename: T J
authors.initials: TJ
authors.lastname: Fletcher
authors.forename: K
authors.initials: K
authors.lastname: Hammond
authors.forename: D
authors.initials: D
authors.lastname: Ward
authors.forename: B P
authors.initials: BP
authors.lastname: Marmion
mesh_terms: D000208:Acute Disease; D016022:Case-Control Studies; D002648:Child; D016997:Coxiella burnetii; D015673:Fatigue Syndrome, Chronic / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011778:Q Fever / Q000150:complications* / Q000453:epidemiology; D011795:Surveys and Questionnaires