title: Levels of serum glycosaminoglycans in renal failure.
abstract: We measured the concentration of serum glycosaminoglycans (GAGs) in patients with glomerulonephritis, renal failure and on hemodialysis using the dye binding method. In glomerulonephritis, concentration of serum GAGs did not increase, and there was no correlation between serum and urinary GAGs. In patients with renal failure and hemodialysis, concentration of serum GAGs was significantly lower than in controls. Concentration of serum GAGs was correlated with concentration of serum albumin, which is an indicator of malnutrition in patients on hemodialysis. One month of hemodialysis did not affect the concentration of serum GAGs in patients with renal failure, but six months of hemodialysis increased the concentration of serum GAGs. These results suggest that matrix production is suppressed in renal failure with malnutrition.
authors.affiliation: Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mitsuhashi
authors.forename: H
authors.initials: H
authors.lastname: Mitsuhashi
authors.forename: S
authors.initials: S
authors.lastname: Yano
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukada
authors.forename: Y
authors.initials: Y
authors.lastname: Nojima
authors.forename: T
authors.initials: T
authors.lastname: Naruse
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000652:urine; D006025:Glycosaminoglycans / Q000097:blood* / Q000652:urine; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000652:urine; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D006025:Glycosaminoglycans; D012709:Serum Albumin