A new splicing variant of a type III POU gene from zebrafish encodes a POU protein with a distinct C-terminal.
A zebrafish POU protein cDNA clone was isolated and sequenced. It appears to be a novel splicing variant of the previously reported zebrafish POU gene zp-12. There are four splicing variants and at least three of them lead to different C-terminal amino acid sequences. The four splicing variants are differentially regulated during development, indicating that they may be functionally diversified.
Lim
J H
JH
School of Biological Sciences, National University of Singapore, Singapore 0511, Singapore.
He
J
J
Korzh
V
V
Gong
Z
Z
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D014644:Genetic Variation; D008969:Molecular Sequence Data; D050809:POU Domain Factors; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015027:Zebrafish / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D050809:POU Domain Factors; D014157:Transcription Factors