title: [Isoxsuprine in hypertension during pregnancy].
abstract: The objective of this paper is to demonstrate that isoxsuprine is an effective, quick hypotensive of easy management in the hypertension of pregnancy that does not have adverse effects on the mother-fetus binomial. This study was carried out at the Obstetric Intensive Care Unit at the Gyneco-Obstretrics Hospital in the Centro Médico Nacional La Raza of the IMSS. Fifty patients were chosen and managed according to the protocol management of the hospital; they had a diagnosis of severe toxemia or preeclampsia in patients with 24 weeks or more of pregnancy, with hypertension, edema, convulsions and/or coma state or without concomitant or previous pathological states. All of the patients received isoxsuprine (50 mg in 250 ml of DW5%). We evaluated the hypotensive effect of isoxsuprine according to the time and average dose administered, and its effect on the mother and fetus heart frequency according to the basal values. We valued the APGAR score at minute one and minute five, seconds after the delivery. We analyzed according to the degrees of toxemia and at the end of the obstetric event. We demonstrated a significant decrease in the arterial tension after administration fifteen minutes later with a dose of nine drops (0.29 mcg/min) average and demonstrated at the same time that there are no adverse effects on the mother fetus binomial. Isoxsuprine is an affective, quick and economical hypotensive of easy management that has no adverse effects on mother-fetus glycemia, obstetric bleeding and APGAR score.
authors.affiliation: Centro Médico La Raza, Instituto Mexicano del Seguro Social, México, D.F.
authors.forename: J C
authors.initials: JC
authors.lastname: Briones-Garduño
authors.forename: R
authors.initials: R
authors.lastname: González-Alvarez
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001034:Apgar Score; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007556:Isoxsuprine / Q000008:administration & dosage / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D011446:Prospective Studies; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000318:Adrenergic beta-Agonists; D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D007556:Isoxsuprine
vernacular_title: Isoxuprina en la hipertensión del embarazo.