title: Accelerated right colonic emptying after simulated upper gut hemorrhage.
abstract: OBJECTIVE
  Upper gastrointestinal hemorrhage delays gastric emptying. Our aim was to evaluate the effect of gastrointestinal hemorrhage on small intestinal, ileocecal, and proximal colonic transit.
  
  
  METHODS
  Healthy volunteers were randomized to receive either a duodenal infusion of heparinized autologous blood (n = 7) or egg white, acting as a control substance with similar composition; 1.5 mCi99mTc-DTPA was added to the infused substances. We infused 30 ml at an infusion rate of 1 ml/min. Gamma-camera images were taken for 4 h or until all radioactivity had entered the colon. Arrival of radiolabels in the colon and also counts in the ascending and transverse colon were quantified.
  
  
  RESULTS
  Small intestinal and ileocecal transit were not significantly different between blood and egg white infusions. However, ascending colonic emptying was significantly faster after blood infusion compared to egg white. Four hours after the start of blood infusion a median of 30% of counts were in the transverse colon (11-50%; 25th-75th percentile) versus 0% (0-7%) after egg white infusion (p < 0.001).
  
  
  CONCLUSIONS
  We concluded that simulated upper gastrointestinal bleeding hastens proximal colonic transit, but does not alter small intestinal transit and colonic filling.
authors.affiliation: Universitätsklinik für Innere Medizin IV, Abteilung für Gastroenterologie und Hepatologie, Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Hammer
authors.forename: K
authors.initials: K
authors.lastname: Lang
authors.forename: K
authors.initials: K
authors.lastname: Kletter
mesh_terms: D000328:Adult; D002432:Cecum / Q000503:physiopathology; D003106:Colon / Q000503:physiopathology*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000503:physiopathology*; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000503:physiopathology; D007421:Intestine, Small / Q000503:physiopathology; D008297:Male; D016284:Technetium Tc 99m Pentetate
chemical_list: D016284:Technetium Tc 99m Pentetate