title: [A study of 5-fluorouracil on bovine trabecular meshwork cells in vitro].
abstract: OBJECTIVE
  To determine whether the clinical use of 5-fluorouracil (5-FU) may have any toxic effects on trabecular meshwork cells.
  
  
  METHODS
  Bovine trabecular meshwork (BTM) cells were cultured in vitro. The effects of 5-FU on BTM cells concerning cellular morphology, ultrastructure, vitality and phagocytosis were observed.
  
  
  RESULTS
  The safe dosage of 5-FU on BTM cell was 1 x 10-6g.ml-1.
  
  
  CONCLUSIONS
  Based on the pharmacokinetic data in the rabbit anterior chamber, it is suggested that the 5-FU dosage of conventional use cause no injury to human trabecular meshwork cells.
authors.affiliation: Department of Ophthalmology, Union Hospital, Tongji Medical University, Wuhan.
authors.forename: F
authors.initials: F
authors.lastname: Jiang
authors.forename: H
authors.initials: H
authors.lastname: Wei
authors.forename: Y
authors.initials: Y
authors.lastname: Lü
mesh_terms: D000818:Animals; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005472:Fluorouracil / Q000633:toxicity*; D010587:Phagocytosis / Q000187:drug effects; D014129:Trabecular Meshwork / Q000166:cytology / Q000187:drug effects*
chemical_list: D005472:Fluorouracil