Antiretroviral therapies.
The use of a combination of more potent antiretroviral agents has resulted in suppression of HIV replication to undetectable levels in many patients. Three classes of antiretroviral drugs are currently available: nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors. A new class of agents, nucleotide reverse transcriptase inhibitors, is expected to be available soon. Clinical studies and indications providing the rationale for use of these agents, contraindications, drug interactions, and adverse reactions are discussed.
Owen
W F
WF
Davies Medical Center, San Francisco, California, USA.
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000075202:Contraindications; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors