title: Piscicidal properties of piperovatine from Piper piscatorum (Piperaceae).
abstract: Extraction of the roots of the Amazonian medicinal plant, Piper piscatorum Trelease and Yuncker, with MeOH and subsequent bioassay guided fractionation using the guppy, Girardina guppii yielded the active amide, N-isobutyl-6-(p-methoxyphenyl) 2E, 4E-hexadieneamide (piperovatine) and a second inactive amide, N-isobutyl-(E)-7-(3,4-methylenedioxyphenyl)hept-2-enamide (pipercallosidine). The former displayed an LC50 of 115 ng/ml in toxicity tests and proved to be the constituent responsible for the dual ethnobotanical uses of this plant: that of fish stupefacient (barbasco) and oral local anesthetic.
authors.affiliation: Division of Biological Sciences, L.H. Bailey Hortorium, Cornell University, Ithaca, NY 14853, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: McFerren
authors.forename: E
authors.initials: E
authors.lastname: Rodriguez
mesh_terms: D000818:Animals; D005399:Fishes; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013011:Sorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C038333:piperovatine; D013011:Sorbic Acid