Insights from in vivo modification of adrenergic receptor gene expression.
Adrenergic receptors are key targets within the autonomic nervous system, regulating a wide variety of physiological processes. The ability to modify adrenergic receptor expression patterns in vivo has added a powerful new tool to the functional analysis of these receptors. Modification of adrenergic receptor gene expression by overexpression, genetic ablation, or site-specific mutation has added new insight to models of receptor coupling behavior, pharmacology, and subtype-specific physiological function. This review highlights some of the recent advances resulting from such genetic approaches to the study of adrenergic receptors.
Rohrer
D K
DK
Department of Molecular and Cellular Physiology, Stanford University, California 94305, USA.
Kobilka
B K
BK
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D011941:Receptors, Adrenergic / Q000096:biosynthesis* / Q000235:genetics*
D011941:Receptors, Adrenergic