title: Functional glomerular reserve in recipients of en bloc pediatric transplant kidneys.
abstract: BACKGROUND
  The transplantation of an adequate renal mass is increasingly recognized to be of importance. The improved graft survival is probably due to a lesser risk of developing hyperfiltration-associated lesions.
  
  
  METHODS
  We have reviewed the glomerular reserve in our recipients of en bloc pediatric transplant kidneys after an intravenous amino acid overload and compared them to single adult kidney transplant recipients.
  
  
  RESULTS
  En bloc transplants evidenced increased glomerular filtration rate as compared with baseline as from the second hour of amino acid infusion (from 71+/-14 to 84.9+/-17 ml/min, 1.73 m2, P<0.05) and increased renal plasma flow as from the third hour (from 335+/-116 to 402+/-155 ml/min, 1.73 m2, P<0.05). In the single adult kidney recipient group, no change was seen either in the glomerular filtration rate (from 62.5+/-13 to 58.1+/-13 ml/min, 1.73 m2, P=NS) nor in renal plasma flow (from 354+/-125 to 304+/-98 ml/min, 1.73 m2, P=NS).
  
  
  CONCLUSIONS
  These results show that patients receiving en bloc pediatric kidney transplantations have a greater renal functional reserve and show a lesser risk of hyperfiltration.
authors.affiliation: Department of Nephrology, San Carlos University Hospital, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Marañes
authors.forename: J A
authors.initials: JA
authors.lastname: Herrero
authors.forename: B
authors.initials: B
authors.lastname: Marron
authors.forename: M
authors.initials: M
authors.lastname: Marques
authors.forename: A
authors.initials: A
authors.lastname: Cruceyra
authors.forename: J
authors.initials: J
authors.lastname: Portoles
authors.forename: D
authors.initials: D
authors.lastname: Prats
authors.forename: A I
authors.initials: AI
authors.lastname: Sanchez-Fructuoso
authors.forename: A
authors.initials: A
authors.lastname: Barrientos
mesh_terms: D000328:Adult; D000367:Age Factors; D000596:Amino Acids / Q000494:pharmacology; D002648:Child; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007668:Kidney / Q000098:blood supply; D007678:Kidney Glomerulus / Q000502:physiology*; D016030:Kidney Transplantation / Q000379:methods; D008875:Middle Aged; D014019:Tissue Donors
chemical_list: D000596:Amino Acids