The invasive prenatal diagnosis in perinatal centre.
Three main methods of prenatal diagnosis (Amniocentesis AMC, Chorionic villi sampling CVS and Cordocentesis FBS) have been used in Perinatal Centre of Central Bohemia. The chromosomal abnormalities in a group of 3,098 patients have been detected in 1.4% of fetuses. The inherited disorders were diagnosed using DNA analysis and biochemical examination of amniotic fluid. X-linked diseases in a group of 68 patients in 30.8% of fetuses have been diagnosed and inborn error of metabolism in a group of 29 indicated patients in 17.2% of fetuses were diagnosed. The incidence of fetal losses before 28th week of gestation was 0.4%.
Hájek
Z
Z
1st Obstetrics and Gynecology Department, 1st Faculty of Medicine, Charles University, Praha, Czech Republic.
Koleska
T
T
Drbohlav
P
P
Spálová
I
I
Macek
M
M
Stejskal
D
D
Kvasnicka
J
J
D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000175:diagnosis; D011247:Pregnancy; D011296:Prenatal Diagnosis