HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.
Recent data point to the immunoregulatory role of extracellular matrix (ECM) proteins in the process of T cell activation. We studied the effects of HIV proteins on those interactions as well as on endothelial adhesion molecule expression. Gp 120 and gp 41 inhibited CD3-triggered T cell co-stimulation by the ECM proteins, while Nef was stimulatory. T cell adhesion to the ECM proteins was affected in a similar fashion. Furthermore, tat induced E-selectin (but not VCAM-1 and ICAM-1) endothelial expression. Those findings may be relevant for the understanding of immunopathology of AIDS.
Mrowiec
T
T
Department of Immunology, Transplantation Institute, University Medical School, Warsaw, Poland.
Melchar
C
C
Górski
A
A
D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000096:biosynthesis* / Q000235:genetics; D002478:Cells, Cultured; D019040:E-Selectin / Q000096:biosynthesis / Q000235:genetics; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D015693:Gene Products, nef / Q000494:pharmacology*; D015696:Gene Products, tat / Q000494:pharmacology*; D015699:HIV Envelope Protein gp120 / Q000494:pharmacology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000235:genetics; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000502:physiology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis / Q000235:genetics; D054311:nef Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D016326:Extracellular Matrix Proteins; D015693:Gene Products, nef; D015696:Gene Products, tat; D015699:HIV Envelope Protein gp120; D008562:Membrane Glycoproteins; D019010:Vascular Cell Adhesion Molecule-1; C053512:glycoprotein 41; D054311:nef Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus; D018799:Intercellular Adhesion Molecule-1