Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with the clinico-pathological manifestations in immunoglobulin A nephropathy patients.
OBJECTIVE
To investigate the relationship between angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and the clinico-pathological manifestations in patients with immunoglobulin nephropathy (IgAN).


METHODS
A flanking primer pair and an insertion-specific primer pair were used to perform two polymerase chain reactions so as to analyse the insertion/deletion polymorphism of ACE gene.


RESULTS
There was a significantly higher genotype frequency for DD genotype in IgAN patients. The frequencies for DD genotype were also higher in those patients with hypertension and/or heavy proteinuria and/or severe glomerular sclerosis (P < 0.05).


CONCLUSIONS
We observed a significant association of the deletion polymorphism of ACE gene with renal insufficiency, hypertension and severe glomerular lesions at biopsy. The deletion allele may play a role, at least to some extent, in the deterioration and progression in IgA nephropathy.
Chen
X
X
Department of Nephrology, General Hospital of Chinese PLA, Military Kidney Center, Beijing, China.
Liu
S
S
Ye
Y
Y
Xu
Q
Q
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D004251:DNA Transposable Elements; D005260:Female; D017353:Gene Deletion; D005922:Glomerulonephritis, IGA / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*
D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A