Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a brief review of a rare condition.
Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis (SAPHO) syndrome is an osteoarticular-skin syndrome characterised by sterile inflammatory arthro-osteitis of the anterior chest wall. It is associated with various skin conditions including palmoplantar pustulosis, severe acnes and pustular psoriasis. A link between SAPHO syndrome and seronegative spondyloarthropathies has been suggested over the last 10 years. SAPHO syndrome mainly affects young and middle-aged adults. Treatment of SAPHO syndrome remains empirical as the underlying aetiopathogenesis is unclear.
Koh
E T
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Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
D000152:Acne Vulgaris; D000328:Adult; D001847:Bone Diseases / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015576:Hyperostosis; D008297:Male; D010000:Osteitis; D011379:Prognosis; D011565:Psoriasis; D012846:Singapore; D013249:Sternum; D013577:Syndrome; D013585:Synovitis