title: The adverse effect of commercial dentine-bonding systems on the skin of guinea pigs.
abstract: It was widely known that 2-hydroxyethyl methacrylate (2-HEMA) can cause contact dermatitis. Commercially available dentine primers and dentine bonding agents that contain 2-HEMA are widely used. The purpose of this study was to investigate the cumulative irritation and delayed hypersensitivity caused by commercial dentine bonding systems when applied to the skin of guinea pigs. We have concluded that almost no dentine bonding systems cause cumulative irritation, but some commercially available dentine bonding systems may produce delayed hypersensitivity.
authors.affiliation: Department of Operative Dentistry, School of Dentistry, University of Showa, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Katsuno
authors.forename: A
authors.initials: A
authors.lastname: Manabe
authors.forename: A
authors.initials: A
authors.lastname: Kurihara
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: H
authors.initials: H
authors.lastname: Hisamitsu
authors.forename: S
authors.initials: S
authors.lastname: Wakumoto
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000009:adverse effects; D017220:Dentin-Bonding Agents / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D017453:Dermatitis, Irritant / Q000209:etiology; D004487:Edema / Q000139:chemically induced; D004890:Erythema / Q000139:chemically induced; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology; D007114:Immunization; D007509:Irritants / Q000009:adverse effects; D008689:Methacrylates / Q000009:adverse effects; D008768:Methylmethacrylates / Q000009:adverse effects; D019279:Resin Cements / Q000009:adverse effects; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000139:chemically induced
chemical_list: D001896:Boron Compounds; C029849:Clearfil Bonding Agent; C112274:Clearfil Liner Bond 2; D017220:Dentin-Bonding Agents; C074806:Imperva-Bond; D007509:Irritants; D008689:Methacrylates; D008768:Methylmethacrylates; D019279:Resin Cements; C074669:Clearfil Photo Bond; C067788:scotchbond 2; C005044:hydroxyethyl methacrylate; C049495:Super-bond