Synthesis of N-benzyl-4-oxo-1,2,3,4-tetrahydrocinnolines.
The method of preparation of N1 and N2-substituted 4-hydroxycinnolines by alkylation with benzyl bromide of the corresponding 4-hydroxycinnolines is described. The obtained derivatives were reduced to the corresponding N-benzyl-4-oxo-1,2,3,4-tetrahydrocinnolines. The effect of some synthesized derivatives on central nervous system was studied.
Stańczak
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Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódź, Poland.
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D000700:Analgesics; D000927:Anticonvulsants; D002491:Central Nervous System Agents; C112393:N-benzyl-4-oxo-1,2,3,4-tetrahydrocinnoline; D009287:Naphthyridines; D011804:Quinolines