title: Pregnancy and dialysis.
abstract: The outcome of pregnancy in patients with end-stage renal failure has long been considered to be extremely poor, and the literature concerning pregnancy while on dialysis is rather scarce. We reviewed the records of five pregnancies in dialysis patients and performed a national survey on this topic. The dialysis technique and dialysis dose, the effects of erythropoietin (EPO), and the evolution of blood pressure levels in our patients are presented. The dose of EPO had to be increased to maintain the hemoglobin level at 10 to 11 g/dL. There was no case of EPO-related hypertension and no need for transfusion. The obstetric data of the national survey, including our own patients, were analyzed. The incidence of pregnancy going beyond the first trimester was 0.3 per 100 patient-years (15 cases in 1,472 females of childbearing age treated, for a total of 4,545 patient-years). In all but one patient initiating pregnancy while already on dialysis, the frequency and dose of dialysis were increased (to a weekly Kt/V of six to eight in our personal cases). The outcome was successful in 50% of pregnancies occurring in hemodialyzed patients and in 80% of patients who started dialysis after initiation of pregnancy. Polyhydramnios was found in eight of 13 cases and growth retardation in two of nine cases. The incidence of low birth weight and prematurity was 100%, and cesarean section was performed in 66% of successful pregnancies. In successful pregnancies, we found a correlation between birth weight and dose of dialysis. Our findings confirm the remarkable improvement in the prognosis of pregnancy in dialysis patients in recent years.
authors.affiliation: Department of Nephrology, Clinique St-Jean, Brussels, Belgium.
authors.forename: J A
authors.initials: JA
authors.lastname: Bagon
authors.forename: H
authors.initials: H
authors.lastname: Vernaeve
authors.forename: X
authors.initials: X
authors.lastname: De Muylder
authors.forename: J J
authors.initials: JJ
authors.lastname: Lafontaine
authors.forename: J
authors.initials: J
authors.lastname: Martens
authors.forename: G
authors.initials: G
authors.lastname: Van Roost
mesh_terms: D000328:Adult; D001794:Blood Pressure; D004921:Erythropoietin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology / Q000628:therapy*; D011994:Recombinant Proteins; D006435:Renal Dialysis
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin