Effect of ashwagandha on lipid peroxidation in stress-induced animals.
The aqueous suspension of root extract of an Indian drug ashwagandha (Withania somnifera L. (Solanaceae)) was evaluated for its effect on lipid peroxidation (LPO) in stress-induced animals. Elevation of LPO was observed in rabbits and mice after intravenous administration of 0.2 microg/kg of lipopolysaccharide (LPS: from Klebsiella pneumoniae) and 100 microg/kg of peptidoglycan (PGN: from Staphylococcus aureus), respectively. The peak was reached immediately after PGN and 2-6 h after LPS administration. Simultaneous oral administration of ashwagandha (100 mg/kg) prevented the rise in LPO in rabbits and mice.
Dhuley
J N
JN
Hindustan Antibiotics Limited, Department of Pharmacology and Toxicology, Research Centre, Pimpri, Pune, India.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000008:administration & dosage; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D013312:Stress, Physiological / Q000378:metabolism*; D032341:Withania
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D010936:Plant Extracts; C030693:Ashwagandha