title: [The case-control design in medical research].
abstract: The aim of this paper is to present a conceptual and practical framework of the case-control design in medical research. To illustrate this method, practical examples directed to clinicians and other health professionals interested in medical research are presented. The case-control method is very versatile and allows for multiple applications. Guidelines for the selection of cases and controls, and some considerations on sample size are presented. In the statistical analysis we use concrete examples of how to estimate odds ratios, confidence intervals, and methods to control for potential confounders, from stratified analysis to logistic regression.
authors.affiliation: Instituto Nacional de Salud Pública de México, Cuernavaca, México.
authors.forename: V H
authors.initials: VH
authors.lastname: Borja-Aburto
authors.forename: S R
authors.initials: SR
authors.lastname: Muñoz
authors.forename: P
authors.initials: P
authors.lastname: Bustamante-Montes
mesh_terms: D016022:Case-Control Studies; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D016015:Logistic Models; D016017:Odds Ratio; D012107:Research Design; D018401:Sample Size
vernacular_title: El diseño de casos y controles en la investigación médica.