[The delivery of loperamide to the brain by using polybutyl cyanoacrylate nanoparticles].
The possibility of using polysorbate 80-coated nanoparticles for the delivery of the water insoluble opioid (lyonist loperamide across the blood-brain barrier was investigated. The analgesic effect after i.v. injection of the preparations was used as the indication of drug transport through this barrier. Intravenous injection of the particulate formulation resulted in a long and significant analgesic effect. A polysorbate 80 loperamide solution induced a much less pronounced and very short analgesia. Uncoated nanoparticles loaded with loperamide were unable to produce analgesia. Polysorbate 80-coated PBCA nanoparticles loaded with loperamide led to the transport of loperamide to the brain.
Aliautdin
R N
RN
Department of Pharmacology, Sechenov Medical Academy, Moscow, Russia.
Petrov
V E
VE
Langer
K
K
Berthold
A
A
Kreuter
J
J
Kharkevich
D A
DA
D000700:Analgesics / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D004337:Drug Carriers; D004655:Emulsions; D004659:Enbucrilate; D008139:Loperamide / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects; D010316:Particle Size; D010592:Pharmaceutic Aids; D011136:Polysorbates; D013997:Time Factors
D000700:Analgesics; D004337:Drug Carriers; D004655:Emulsions; D010592:Pharmaceutic Aids; D011136:Polysorbates; D008139:Loperamide; D004659:Enbucrilate
Dostavka loperamida v mozg s pomoshch'iu polibutiltsianoarilatnykh nanochastits.