Marked improvement of tardive dystonia after replacing haloperidol with risperidone in a schizophrenic patient.
We report on a schizophrenic patient whose tardive dystonia, delusions, and auditory hallucinations showed remarkable concurrent improvement after replacing haloperidol with risperidone. The present finding suggests that the 5-hydroxytryptamine-2 (5-HT2) antagonistic action of risperidone has brought about the improvement in tardive dystonia. The 5-HT2 antagonistic action of risperidone, in addition to its dopamine antagonistic action, may have also lessened psychotic symptoms in the current case.
Yoshida
K
K
Department of Neuropsychiatry, Akita University School of Medicine, Japan.
Higuchi
H
H
Hishikawa
Y
Y
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D004421:Dystonia / Q000139:chemically induced* / Q000503:physiopathology; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D014150:Antipsychotic Agents; D012702:Serotonin Antagonists; D006220:Haloperidol; D018967:Risperidone