Predictive value of in vitro model systems in toxicology.
The application of in vitro model systems to evaluate the toxicity of xenobiotics has significantly enhanced our understanding of drug- and chemical-induced target toxicity. From a scientific perspective, there are several reasons for the popularity of in vitro model systems. From the public perspective, in vitro model systems enjoy increasing popularity because their application may allow a reduction in the number of live animals employed in toxicity testing. In this review, we present an overview of the use of in vitro model systems to investigate target organ toxicity of drugs and chemicals, and provide selective examples of these model systems to better understand cutaneous and ocular toxicity and the role of drug metabolism in the hepatotoxicity of selected agents. We conclude by examining the value and use of in vitro model systems in industrial development of new pharmaceutical agents.
Davila
J C
JC
G.D. Searle, Product Safety Assessment, Skokie, Illinois 60077, USA.
Rodriguez
R J
RJ
Melchert
R B
RB
Acosta
D
D
D000826:Animal Testing Alternatives; D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008954:Models, Biological; D011237:Predictive Value of Tests; D014116:Toxicology / Q000379:methods*; D015262:Xenobiotics / Q000633:toxicity*
D015262:Xenobiotics