Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43.
There is genetic predisposition associated with >=10% of all cancer of the prostate (CaP). By means of a genomewide search on a selection of 47 French and German families, parametric and nonparametric linkage (NPL) analysis allowed identification of a locus, on chromosome 1q42.2-43, carrying a putative predisposing gene for CaP (PCaP). The primary localization was confirmed with several markers, by use of three different genetic models. We obtained a maximum two-point LOD score of 2.7 with marker D1S2785. Multipoint parametric and NPL analysis yielded maximum HLOD and NPL scores of 2.2 and 3.1, respectively, with an associated P value of . 001. Homogeneity analysis with multipoint LOD scores gave an estimate of the proportion of families with linkage to this locus of 50%, with a likelihood ratio of 157/1 in favor of heterogeneity. Furthermore, the 9/47 families with early-onset CaP at age <60 years gave multipoint LOD and NPL scores of 3.31 and 3.32, respectively, with P = .001.
Berthon
P
P
Département d'Urologie, Université Paris VII, Hôpital Saint Louis, Paris, France. p.berthon@chu-stlouis.fr
Valeri
A
A
Cohen-Akenine
A
A
Drelon
E
E
Paiss
T
T
Wöhr
G
G
Latil
A
A
Millasseau
P
P
Mellah
I
I
Cohen
N
N
Blanché
H
H
Bellané-Chantelot
C
C
Demenais
F
F
Teillac
P
P
Le Duc
A
A
de Petriconi
R
R
Hautmann
R
R
Chumakov
I
I
Bachner
L
L
Maitland
N J
NJ
Lidereau
R
R
Vogel
W
W
Fournier
G
G
Mangin
P
P
Cussenot
O
O
D017668:Age of Onset; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D011471:Prostatic Neoplasms / Q000235:genetics*