title: Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis.
abstract: BACKGROUND
  Chronic sinusitis (CS) is a common disease in children, especially those with allergies, that is caused by impaired drainage from the sinuses. Hypertonic NaCl solution has been shown to increase mucociliary clearance and ciliary beat frequency.
  
  
  OBJECTIVE
  We performed a randomized double blind study to compare the effect of nasal wash with hypertonic saline (HS) (3.5%) versus normal saline (NS) (0.9%) on CS.
  
  
  METHODS
  Thirty patients with CS aged 3 to 16 years were studied. They were randomly divided into two treatment groups matched by age and severity of the disease. Each individual was treated with either HS or NS for 4 weeks. All patients were evaluated by two clinical scores (cough and nasal secretions/postnasal drip [PND]) and by a radiology score at the beginning of the study and after 4 weeks.
  
  
  RESULTS
  The HS group improved significantly in all scores (average +/- SD): cough score, from 3.6 +/- 0.51 to 1.6 +/- 0.74; nasal secretion/PND score, from 2.86 +/- 0.35 to 1.6 +/- 0.74; and radiology score, from 8.06 +/- 1.28 to 2.66 +/- 1.04. The NS treatment group showed significant improvement only in the PND score (from 2.66 +/- 0.49 to 1.53 +/- 0.83) but no significant change in both the cough score (from 3.53 +/- 0.52 to 3.33 +/- 0.49) and the radiology score (from 8.13 +/- 1.25 to 7.86 +/- 0.91). Clinical observation 1 month after the end of the study showed no change compared with the end of the study in both groups.
  
  
  CONCLUSIONS
  HS nasal wash is an efficient treatment of CS.
authors.affiliation: Pediatric Department, Bikur Cholim Hospital, Hadassa Medical School, Jerusalem, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Shoseyov
authors.forename: H
authors.initials: H
authors.lastname: Bibi
authors.forename: P
authors.initials: P
authors.lastname: Shai
authors.forename: N
authors.initials: N
authors.lastname: Shoseyov
authors.forename: G
authors.initials: G
authors.lastname: Shazberg
authors.forename: H
authors.initials: H
authors.lastname: Hurvitz
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D017817:Nasal Lavage Fluid; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012852:Sinusitis / Q000188:drug therapy*; D012965:Sodium Chloride; D016896:Treatment Outcome
chemical_list: D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride