Time-dependent alterations in corticotropin-releasing factor-like immunoreactivity in different brain regions after acute cocaine administration to rats.
Recent data from various laboratories suggest that the activation of endogenous corticotropin-releasing factor (CRF) may contribute to the behavioral and neuroendocrine effects of cocaine. In the present study, the time-dependent variations in CRF-like immunoreactivity (CRF-LI) in the hypothalamus and several extrahypothalamic brain regions were determined after acute cocaine administration to handled rats. The intraperitoneal injection of 7.5 mg/kg cocaine led to a significantly decreased CRF-LI level in the basal forebrain and to a significantly increased CRF-LI level in the amygdala 60 min after administration, while the CRF-LI content was decreased in the hypothalamus and in the hippocampus 180 min after cocaine treatment. These results suggest that the durations of the effects of cocaine on CRF-LI are in the brain region-specific, which might contribute to the mediation of the diverse behavioral and neuroendocrine effects of cocaine.
Gardi
J
J
Endocrine Unit, Albert Szent-Györgyi Medical University, Szeged, Hungary. gardi@endoc.szote.u-szeged.hu
Bíró
E
E
Sarnyai
Z
Z
Vecsernyés
M
M
Julesz
J
J
Telegdy
G
G
D000679:Amygdala / Q000737:chemistry / Q000187:drug effects; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000032:analysis / Q000276:immunology* / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D005625:Frontal Lobe / Q000737:chemistry / Q000187:drug effects; D006624:Hippocampus / Q000737:chemistry / Q000187:drug effects; D007031:Hypothalamus / Q000737:chemistry / Q000187:drug effects; D008297:Male; D009714:Nucleus Accumbens / Q000737:chemistry / Q000187:drug effects; D009833:Olfactory Pathways / Q000737:chemistry / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012686:Septal Nuclei / Q000737:chemistry / Q000187:drug effects; D013997:Time Factors
D018765:Dopamine Uptake Inhibitors; D003346:Corticotropin-Releasing Hormone; D003042:Cocaine