The effect of isradipine on maximal electroshock seizures in mice.
1. The aim of this study was to investigate the possible anticonvulsant effect of a dihydropyridine calcium antagonist, isradipine, which easily crosses the blood-brain barrier displaying high affinity and specificity for the brain L-type voltage-sensitive calcium channel, on maximal electroshock seizures in mice. 2. Isradipine at i.p. doses of 2.5 mg/kg and 5.0 mg/kg was found to cause a statistically significant increase in the convulsion threshold of maximal electroshock seizures in a dose-dependent manner (P = 0.047 and P = 0.022, respectively). 3. It was concluded that the mode of action of the anticonvulsant effect of isradipine is related to blockade of the intraneuronal calcium currents, which play an important role in epileptic activity.
Ozyazgan
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S
Department of Pharmacology, University of Istanbul, Cerrahpaşa, Faculty of Medicine, Turkey.
Senses
V
V
Utkan
T
T
Yildiran
G
G
Ulak
G
G
Gacar
N
N
Ozüner
Z
Z
Akkan
A G
AG
D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001812:Blood-Brain Barrier; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D005260:Female; D017275:Isradipine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology
D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D017275:Isradipine