[Current issues in clinical radiobiology and ways of resolving them experimentally].
Information being collected for some tens year in frame of clinical study of radiation effects in man in broad range of dose and exposure variants has been summarised and systematized. It has been formulated the questions which could be answered under only clinical observation with many difficulties: diagnostical and prognostical criteria for evaluation of therapy efficiency in non-bone marrow syndrome of acute radiation disease choice and conformity of methods of bone marrow syndrome therapy in overlethal range of dose; improving of preclinical examination of means and methods of acute radiation syndrome prophylaxis and treatment; comparative analysis of the role of various radiation factors in development of oncological and severe somatic diseases and possibility of these effects modification. Some limitations in extrapolation of experimental data onto clinical practice has been discussed and optimal forms of cooperation are shown.
Gus'kova
A K
AK
State Research Center of Russian Federation, Institute of Biophysics, Moscow.
D001853:Bone Marrow / Q000528:radiation effects; D006801:Humans; D007422:Intestines / Q000528:radiation effects; D008168:Lung / Q000528:radiation effects; D011832:Radiation Injuries / Q000628:therapy*; D018788:Radioactive Hazard Release; D011853:Radiobiology / Q000379:methods*; D012307:Risk Factors; D013577:Syndrome
Aktual'nye voprosy klinicheskoĭ radiobiologii i puti ikh éksperimental'nogo razresheniia.