Arachidonic acid metabolism: a primer for head and neck surgeons.
The arachidonic acid metabolites, or eicosanoids, are a large series of lipid-derived mediators capable of producing a multitude of physiologic effects in the local environment. They play important roles in a variety of signaling pathways in endocrinology, immunology, and oncology. A significant body of work in this area has occurred in squamous cell carcinomas of the head and neck over the past 15 years. This review will attempt to familiarize the head and neck surgical oncologist with the basic biochemical steps in the formation of these compounds, newer developments in the field of eicosanoid biochemistry, and related experimental evidence of the roles of these substances in head and neck cancer.
Ondrey
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Tumor Cell Biology Section/Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institute of Health, Bethesda, Maryland 20892, USA.
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D004195:Disease Models, Animal; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000378:metabolism; D006801:Humans; D015289:Leukotrienes / Q000096:biosynthesis; D008084:Lipoxygenase / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis; D015398:Signal Transduction / Q000502:physiology*
D005231:Fatty Acids, Unsaturated; D015289:Leukotrienes; D011453:Prostaglandins; D016718:Arachidonic Acid; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases