title: Early cutaneous lesions secondary to hydroxyurea therapy.
abstract: Hydroxyurea is a usually well-tolerated cytostatic agent, but its side effects include cutaneous lesions that appear after several years of maintenance therapy with hydroxyurea. The reported incidence of such adverse reactions varies from 10 to 35%; in our Center it is 2%. We describe a patient with essential thrombocythemia who presented with ulcers of the hands only 15 days after hydroxyurea treatment.
authors.affiliation: Serivzio di Ematologia, Istituto di Scienze Mediche, Università di Milano, Ospedale Maggiore, I.R.C.C.S., Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Radaelli
authors.forename: R
authors.initials: R
authors.lastname: Calori
authors.forename: P
authors.initials: P
authors.lastname: Faccini
authors.forename: A T
authors.initials: AT
authors.lastname: Maiolo
mesh_terms: D000368:Aged; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology; D013922:Thrombocytosis / Q000188:drug therapy; D013997:Time Factors
chemical_list: D006918:Hydroxyurea