title: Limited allelic polymorphism in the human interleukin-3 gene.
abstract: Interleukin-3 (IL-3) is a cytokine expressed primarily in activated T cells mast cells and natural killer (NK) cells. Interleukin-3 has the capability to stimulate the proliferation and differentiation of multipotential stem cells and has a role in shaping the immune response. In order to better understand the biological role of IL-3, a study of polymorphisms within the human IL-3 gene and its upstream regulatory elements has been conducted. Using a modification of the bidirectional dideoxy fingerprinting method, a group of 88 Caucasoid individuals were screened for polymorphism in the IL-3 enhancer, promoter and gene coding regions. Analysis revealed the presence of several infrequent polymorphisms which may affect IL-3 functionality.
authors.affiliation: Department of Neurology, School of Medicine, University of California, San Francisco, CA 94143-0435, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Jeong
authors.forename: A
authors.initials: A
authors.lastname: Navani
authors.forename: J R
authors.initials: JR
authors.lastname: Oksenberg
mesh_terms: D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D004742:Enhancer Elements, Genetic; D005091:Exons; D006801:Humans; D007377:Interleukin-3 / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D017931:DNA Primers; D007377:Interleukin-3