title: Optimizing emergency care of upper gastrointestinal bleeding in cirrhotic patients.
abstract: The type of emergency treatment administered to patients with suspected variceal bleeding is important, as the episode is associated with a high mortality rate. Moreover, rebleeding is common during the first few days after the initial haemorrhage. Several techniques are available to control variceal haemorrhage including pharmacotherapy (vasopressin, terlipressin, somatostatin and octreotide), balloon tamponade, endoscopic techniques, transjugular intrahepatic portosystemic shunt and shunt surgery. The majority of these require specialized equipment and/or experienced personnel, which are not always available in every hospital. In such situations, pharmacotherapy represents the most practical method of establishing haemodynamic control prior to the administration of definitive treatment. Pharmacotherapy can be initiated immediately upon admission to stabilize the patient prior to diagnostic endoscopy, which subsequently improves the efficacy and ease of administration of further endoscopic intervention. The optimal pharmacological agent should be both effective and safe. A drug with no side effects will not complicate the management of critical patients and can be administered over an extended period to reduce the incidence of rebleeding and improve prognosis. Meta-analysis of clinical studies has revealed that of the vasoactive drugs available somatostatin is effective with significantly fewer side effects and currently appears to represent the best choice for treatment. The available evidence suggests that the early administration of pharmacotherapy, as part of a specific treatment regimen, offers significant benefit to patients with variceal bleeding and its administration optimizes emergency care.
authors.affiliation: Dept. of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK.
authors.forename: A K
authors.initials: AK
authors.lastname: Burroughs
authors.forename: R
authors.initials: R
authors.lastname: Planas
authors.forename: P
authors.initials: P
authors.lastname: Svoboda
mesh_terms: D002986:Clinical Trials as Topic; D003663:Decision Trees; D004632:Emergency Medical Services / Q000379:methods*; D004932:Esophageal and Gastric Varices / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D013004:Somatostatin / Q000627:therapeutic use*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
chemical_list: D014662:Vasoconstrictor Agents; D013004:Somatostatin