N4-hydroxy-5-halogeno-2'-deoxycytidine S and their 5'-mono-phosphates as inhibitors of thymidylate synthase and in vitro antileukemic agents.
Felczak
K
K
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland.
Bretner
M
M
Dzik
J M
JM
Gołos
B
B
Zieliński
Z
Z
Rode
W
W
Kulikowski
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000633:toxicity; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000633:toxicity; D005467:Floxuridine / Q000493:pharmacokinetics / Q000633:toxicity; D007700:Kinetics; D007940:Leukemia L5178; D051379:Mice; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D005467:Floxuridine; D003841:Deoxycytidine; D013940:Thymidylate Synthase