title: Increased survival and deteriorating developmental outcome in 23 to 25 week old gestation infants, 1990-4 compared with 1984-9.
abstract: OBJECTIVE
  To assess whether changes in survival over time in infants of 23 to 25 weeks of gestational age were accompanied by changes in the incidence of disability in childhood during an 11 year period.
  
  
  METHODS
  Obstetric and neonatal variables having the strongest association with both survival to discharge from a regional neonatal medical unit and neurodevelopmental disability in 192 infants of 23 to 25 weeks of gestation, born in 1984 to 1994, were studied as a group and in two cohorts (1984 to 1989 n = 96 and 1990 to 1994 n = 96). The data collected included CRIB (clinical risk index for babies) scores and cranial ultrasound scan findings. The children were followed up at outpatient clinics.
  
  
  RESULTS
  Between 1984 and 1989 (cohort 1) and 1990 and 1994 (cohort 2) the rate of survival to discharge increased significantly from 27% to 42% and the rate of disability in survivors increased from 38% to 68%; most of this increase was in mild disability. The proportions of survivors with cerebral palsy did not alter significantly (21% vs 18%), but more survivors with blindness due to retinopathy of prematurity (4% vs 18%), myopia (4% vs 15%) and squints (8% vs 13%) contributed to the increased rate of disability. Clinically significant cranial ultrasound findings and a high CRIB score were strongly associated with death. A high CRIB score was most strongly associated with disability.
  
  
  CONCLUSIONS
  The rise in disability with improved survival was not due to cerebral palsy; rather the main contributors were blindness due to retinopathy, myopia, and squint. The causes of these disabilities seem to be linked to high CRIB scores. A system of regular and skilled retinal examination and access to facilities for retinal ablation should be in place in all neonatal units which undertake the care of such extremely preterm infants.
authors.affiliation: Department of Child Health, University of Manchester, St Mary's Hospital.
authors.forename: H C
authors.initials: HC
authors.lastname: Emsley
authors.forename: S P
authors.initials: SP
authors.lastname: Wardle
authors.forename: D G
authors.initials: DG
authors.lastname: Sims
authors.forename: M L
authors.initials: ML
authors.lastname: Chiswick
authors.forename: S W
authors.initials: SW
authors.lastname: D'Souza
mesh_terms: D001724:Birth Weight; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007226:Infant Mortality / Q000639:trends*; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D008297:Male; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D015996:Survival Rate