[The effect of tinidazole in the treatment of adult periodontitis].
Fifty-two adult periodontitis patients were treated by the tablets of tinidazole (TNZ), and 23 patients treated by metronidazole (MNZ) served as control group. The effective rate of TNZ in adult periodontitis patients was 73.1%, which was significantly higher than that of the control group (43.5%). Antimicrobial studies showed that the capability of TNZ to kill the periodontal dominant anaerobic bacteria, especially B. gingivalis and B. melaninogenicus, was better than that of MNZ. The minimal inhibitory concentration (MIC) of TNZ to Bacteroides, Fusobacterium, Veillonella, Eubacterium, Antinomyces, Peotostreptococus and Anaerobic Streptococus was lower than that of MNZ and actylspiramycine.
Wang
R
R
Department of Stomatology, Zhejiang Provincial People's Hospital, Hangzhou.
Chen
L
L
Ni
K
K
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016866:Bacteroidaceae Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000187:drug effects; D001443:Prevotella melaninogenica / Q000187:drug effects; D014011:Tinidazole / Q000494:pharmacology / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D014011:Tinidazole; D008795:Metronidazole