A case of sulindac-induced enteropathy resulting in jejunal perforation.
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for rheumatic conditions. Their effects on the upper gastrointestinal tract are well recognised. Clinically important damage to the small intestines is less common and often unrecognised. We report a case of sulindac-induced jejunal perforation in a rheumatoid arthritis (RA) patient with previous gastrectomy for gastric carcinoma. The prevalence, diagnosis, pathogenesis and treatment options of NSAID-induced enteropathy will be discussed.
Yoon
K H
KH
Department of Medicine, Alexandra Hospital, Singapore.
Ng
S C
SC
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy; D018572:Disease-Free Survival; D004751:Enteritis / Q000139:chemically induced; D006801:Humans; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D007579:Jejunal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013467:Sulindac / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013467:Sulindac