Neutropenia complicating Rh-hydrops fetalis: the effect of treatment with recombinant human granulocyte colony-stimulating factor (rhG-CSF).
Neutropenia is a less commonly encountered feature of Rh hemolytic disease of the newborn, and its management may be problematic. Two newborn infants with neutropenia complicating Rh incompatibility-induced hydrops fetalis were treated with intravenous recombinant human granulocyte colony-stimulating factor (rhG-CSF), 5 micrograms/kg/day for 5 days. Both patients responded to therapy with a rapid and persistent increase of their neutrophil counts to normal values. The treatment was well tolerated and no adverse clinical events were observed. rhG-CSF induces a significant increase in peripheral absolute neutrophil counts of neutropenic neonates with Rh hydrops fetalis and was well tolerated. The contribution of rhG-CSF to clinical recovery warrants further investigation.
Segal
N
N
Department of Pediatrics, Kaplan Medical Center, Rehovot, Israel.
Leibovitz
E
E
Juster-Reicher
A
A
Even-Tov
S
S
Mogilner
B
B
Barak
Y
Y
D000328:Adult; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D015160:Hydrops Fetalis / Q000150:complications*; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood; D008297:Male; D009503:Neutropenia / Q000209:etiology* / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
D007518:Isoantibodies; D011994:Recombinant Proteins; D012204:Rh-Hr Blood-Group System; D016179:Granulocyte Colony-Stimulating Factor