title: [Morphine antibodies in the mechanisms of morphine resistance, morphine tolerance and of the action of an antagonist].
abstract: It was found that the absence of the analgesic effect of morphine, as determined by the tail-flick test, in morphine-resistant and morphine-tolerant rats, as well as in naloxane blockade of morphine analgesia in morphine-sensitive rats was attended with a four- to eight-fold increase in morphine antibodies in the plasma, as determined by the ELISA method. It is suggested that a pharmacokinetic factor mediated through immune reactions of morphine antibodies formation is one of the mechanisms of such conditions.
authors.affiliation: Department of Higher Nervous Activity, Lomonsov Moscow State University, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Kaliuzhnyĭ
authors.forename: S V
authors.initials: SV
authors.lastname: Litvinova
authors.forename: A L
authors.initials: AL
authors.lastname: Kaliuzhnyĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Aristova
authors.forename: M A
authors.initials: MA
authors.lastname: Gruden'
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Kozlov
authors.forename: G V
authors.initials: GV
authors.lastname: Torgovanova
authors.forename: O V
authors.initials: OV
authors.lastname: Fedoseeva
mesh_terms: D000375:Aging / Q000187:drug effects / Q000276:immunology; D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000187:drug effects* / Q000494:pharmacology; D004351:Drug Resistance; D004361:Drug Tolerance; D006358:Hot Temperature; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000276:immunology* / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013623:Tail
chemical_list: D001323:Autoantibodies; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine
vernacular_title: Antitela k morfinu v mekhanizmakh morfinnoĭ rezistentnosti, morfinnoĭ tolerantnosti i deĭstviia antagonista.