title: Antifungal amide from leaves of Piper hispidum.
abstract: Bioactivity-guided fractionation of a CH2Cl2 extract from leaves of Piper hispidum (Piperaceae) yielded a new pyrrolidine amide, N-[7-(3',4'-methylenedioxyphenyl)-2(Z),4(Z)-heptadienoyl] pyrrolidine 1, in addition to two known amides N-[5-(3', 4'-methylenedioxyphenyl)-2(E)-pentadienoyl] pyrrolidine and N-[2-(3', 4'-methylenedioxy-6'-methoxyphenyl)-2(Z)-propenoyl]pyrrolidine. The structure of compound 1 was elucidated by interpretation of spectral data, including ES-MS. Compound 1 showed antifungal activity against Cladosporium sphaerospermum.
authors.affiliation: Instituto de Química, Universidade Estadual Paulista, CP 355, 14800-900, Araraquara-SP, Brazil.
authors.forename: A C
authors.initials: AC
authors.lastname: Alécio
authors.forename: V
authors.initials: V
authors.lastname: da Silva Bolzani
authors.forename: M C
authors.initials: MC
authors.lastname: Young
authors.forename: M J
authors.initials: MJ
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Furlan
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002963:Cladosporium / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D010944:Plants / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D000935:Antifungal Agents; C112718:N-(7-(3',4'-methylenedioxyphenyl)-2,4-heptadienoyl)pyrrolidine; D011759:Pyrrolidines