[Genes stimulated by tissue hypoxia].
Hypoxia is a frequent pathogenetic stimulus to which the whole organism as well as affected tissues and cells respond by various adaptive mechanisms. The basis of these reactions is the ability of cells to monitor the concentration of oxygen molecules by oxygen sensors. Some of these reactions are the result of the association of the oxygen sensor of the cell with its genome. This association makes it possible to enhance the activity or activation of some genes. Products of these genes increase the resistance of cells to hypoxia, they induce an increased vascularization of the affected tissue, increased erythrocyte production and some other reactions. In tumour hypoxia can cause by this mechanism changes of its properties and its malignization.
Necas
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Ustav patologické fyziologie 1, Praha.
D000818:Animals; D015687:Cell Hypoxia / Q000235:genetics*; D016228:Endothelial Growth Factors / Q000235:genetics; D004921:Erythropoietin / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D010100:Oxygen / Q000378:metabolism
D016228:Endothelial Growth Factors; D004921:Erythropoietin; D010100:Oxygen
Geny stimulované tkánovou hypoxií.