Effects of endoluminal stent-grafts on acute aortic dissection in dogs.
Acute aortic dissection is a life-threatening condition, and may be treated with aggressive hypotensive drug therapy, but emergency surgery is often necessary. We evaluated the effectiveness of stent-grafts for the treatment of acute aortic dissection. Aortic dissection was surgically created in the descending thoracic aorta in 20 adult mongrel dogs. A stent-graft was inserted in the entry position. The tested animals were divided into 4 groups based on re-entry type and blood pressure alteration rate (AR) after acute aortic dissection. After insertion of the stent, the following results were observed: a) AR improved; b) proximal descending aorta and superior mesenteric arterial flows increased; c) cardiac function improved; and d) the dissecting aortic diameter decreased in the presence of pressure gradient group. From these results, insertion of a stent-graft to treat acute aortic dissection was judged to be effective.
Yunoki
K
K
Department of Cardiovascular Surgery, Okayama University Medical School, Japan.
Uchida
H
H
Sano
S
S
Shimizu
N
N
D000208:Acute Disease; D000784:Aortic Dissection / Q000503:physiopathology / Q000601:surgery*; D000818:Animals; D001011:Aorta / Q000473:pathology / Q000503:physiopathology; D017545:Aortic Aneurysm, Thoracic / Q000503:physiopathology / Q000601:surgery*; D001027:Aortography; D001794:Blood Pressure / Q000502:physiology; D001807:Blood Vessel Prosthesis; D002302:Cardiac Output / Q000502:physiology; D004285:Dogs; D011651:Pulmonary Artery / Q000503:physiopathology; D012039:Regional Blood Flow; D015607:Stents; D014655:Vascular Resistance / Q000502:physiology