[Effects of interleukin-1 on the differentiation of osteoblasts].
By use of quantitative histochemistry, effects of interleukin 1 (IL1) on the differentiation of osteoblasts derived from neonatal rabbit calvaria were studied. The results showed that IL 1 inhibits the alkaline phosphatase activity in the cultured osteoblasts. Also, both quantitative immunohistochemistry study and radioimmunoassay study showed that IL-1 has the ability to stimulate osteocalcin production and secretion in the cultured osteoblasts. Our results suggest that IL 1 plays a role in the regulation of osteoblastic differentiation, and in the end inhibits the calcification of bone matrix.
Zhang
W
W
School of Stomatology, Beijing Medical University.
Yu
S
S
Zheng
L
L
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D007375:Interleukin-1 / Q000494:pharmacology*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D015675:Osteocalcin / Q000096:biosynthesis; D011817:Rabbits
D007375:Interleukin-1; D015675:Osteocalcin; D000469:Alkaline Phosphatase