Association between cytomegalovirus seroconversion and upper genital tract infection among women attending a sexually transmitted disease clinic: a prospective study.
To study relationships between acquisition of cytomegalovirus (CMV), sexual activity, and sexually transmitted diseases, 245 CMV-seronegative women were followed (median, 23 months) in a sexually transmitted disease clinic between 1980 and 1988. Thirty-six (15%) seroconverted (10%-12%/year). At entry, seroconverters were younger (P = .03), were younger at sexual debut (P = .004), and had more sex partners (P = .004) than non-seroconverters. During follow-up, seroconverters had more sex partners, had more new sex partners (P = .05 for each), and were more likely to have gonorrhea, chlamydia, or pelvic inflammatory disease. At seroconversion, Chlamydia trachomatis was isolated from cervix in 14%, versus 3% of non-seroconverters (odds ratio [OR], 4.5; 95% confidence interval [CI], 1.3-14.9). Signs of upper genital tract infection were present in 8% of seroconverters versus 2% of non-seroconverters (OR, 4.7; 95% CI, 1.0-21.8). Acquisition of CMV in these women was associated with sexual activity, sexually transmitted diseases, and signs of upper genital tract infection.
Coonrod
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Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA.
Collier
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Ashley
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DeRouen
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Corey
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D000293:Adolescent; D000328:Adult; D002690:Chlamydia Infections / Q000150:complications / Q000453:epidemiology*; D002692:Chlamydia trachomatis; D015331:Cohort Studies; D003153:Community Health Services; D003586:Cytomegalovirus Infections / Q000150:complications / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005831:Genital Diseases, Female / Q000453:epidemiology* / Q000382:microbiology / Q000821:virology; D006801:Humans; D016017:Odds Ratio; D011446:Prospective Studies; D012725:Sexual Behavior; D015231:Sexually Transmitted Diseases, Bacterial / Q000150:complications / Q000453:epidemiology*; D015229:Sexually Transmitted Diseases, Viral / Q000150:complications / Q000453:epidemiology*; D013997:Time Factors; D014861:Washington