[The seizures induced by N-methyl-D,L-aspartate administration are accompanied by an enhancement of nitric oxide generation and of lipid peroxidation processes in the rat brain].
EPR-spectrometry was performed to study the nitrous oxide (NO) content and the intensity of lipid peroxidation (LPO) in the brain cortex of rats during convulsions induced by intracerebral injection of N-methyl-D,L-aspartate (NMDLA). It was shown that the convulsions were attended with a fourfold increase in the NO content and activation of LPO in the rat brain cortex. Disocilpin injection fully prevented the development of convulsions as well as increase in the NO level and LPO activation caused by NMDLA injection. N-nitro-L-arginine had an anticonvulsive effect and prevented increase in the NO content but did not cause any noticeable effect on LPO intensity in the brain cortex.
Raevskiĭ
K S
KS
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Bashkatova
V G
VG
Vitskova
G Iu
GIu
Narkevich
V B
VB
Mikoian
V D
VD
Vanin
A F
AF
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular; D015227:Lipid Peroxidation / Q000187:drug effects*; D016202:N-Methylaspartate / Q000008:administration & dosage; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D019335:Nitroarginine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
D000927:Anticonvulsants; D004791:Enzyme Inhibitors; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D019335:Nitroarginine; D009569:Nitric Oxide; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D019001:Nitric Oxide Synthase
Sudorogi, vyzvaemye vvedeniem N-metil-D,L-aspartata, soprovozhdaiutsia usileniem generatsii oksida azota i protsessov perekisnogo okisleniia lipidov v mozge krys.