title: Adherence of phenotypically switched Candida albicans to denture base materials.
abstract: OBJECTIVE
  The purpose of this study was to investigate in vitro the levels of adhesion of phenotypically switched and nonswitched Candida albicans to the smooth and rough surfaces of heat-cured acrylic resin, Molloplast B, and Novus.
  
  
  METHODS
  Nonswitched and switched cells of C. albicans 3153A were prepared and adhesion assays were performed.
  
  
  RESULTS
  There was no difference in the level of adhesion of blastospores in their nonswitched or switched state. The adherence of hyphae to all three denture base materials was statistically significantly increased when in a switched form. There was greater adhesion to the two soft lining materials than to the acrylic resin.
  
  
  CONCLUSIONS
  Rough surfaces promote adhesion. There was no significant difference in the adhesion of switched and nonswitched blastospores, but there was increased adhesion of hyphal cells.
authors.affiliation: Department of Prosthetic Dentistry, United Medical and Dental Schools, Guys Dental Hospital, University of London, United Kingdom.
authors.forename: D R
authors.initials: DR
authors.lastname: Radford
authors.forename: S J
authors.initials: SJ
authors.lastname: Challacombe
authors.forename: J D
authors.initials: JD
authors.lastname: Walter
mesh_terms: D000180:Acrylic Resins; D000704:Analysis of Variance; D002176:Candida albicans / Q000235:genetics / Q000472:pathogenicity*; D003764:Dental Materials; D003819:Denture Bases / Q000382:microbiology* / Q000706:statistics & numerical data; D005800:Genes, Fungal; D005812:Genes, Switch; D010641:Phenotype; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D003764:Dental Materials