title: Antibacterial and anti-inflammatory agents that target endotoxin.
abstract: Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of lipopolysaccharide endotoxins in Gram-negative bacteria, is an intriguing target for new antibacterial and anti-inflammatory agents. Inhibition of lipid A biosynthesis kills most Gram-negative bacteria, increases bacterial permeability to antibiotics and decreases endotoxin production.
authors.affiliation: Dept of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Wyckoff
authors.forename: C R
authors.initials: CR
authors.lastname: Raetz
authors.forename: J E
authors.initials: JE
authors.lastname: Jackman
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008050:Lipid A / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000502:physiology; D008969:Molecular Sequence Data; D018805:Sepsis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D008050:Lipid A