title: Incidence and clinical manifestations of activated protein C resistance and factor V Leiden in young patients with venous thromboembolic disease in Spain.
abstract: In order to evaluate the actual incidence and clinical repercussion of activated protein C resistance (APCR) in our area, we performed a coagulation and thrombophillic study on 65 young patients diagnosed with deep vein thrombosis and 53 controls. Family and genetic study was carried out in APC-resistant patients. We found APCR in 26.15% of patients and the 77.7% of these and their relative were heterozygous for factor V Leiden. There's a clear relationship between phenotype APCR and thrombosis, and also between factor V Leiden and thrombosis.
authors.forename: T
authors.initials: T
authors.lastname: Olave
authors.forename: R
authors.initials: R
authors.lastname: Cornudella
authors.forename: C
authors.initials: C
authors.lastname: Homs
authors.forename: G
authors.initials: G
authors.lastname: Azaceta
authors.forename: I
authors.initials: I
authors.lastname: Tirado
authors.forename: M
authors.initials: M
authors.lastname: Gutierrez
mesh_terms: D000293:Adolescent; D000328:Adult; D004351:Drug Resistance; D005165:Factor V / Q000502:physiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011486:Protein C / Q000502:physiology*; D013030:Spain / Q000453:epidemiology; D013924:Thrombophlebitis / Q000453:epidemiology* / Q000503:physiopathology*
chemical_list: D011486:Protein C; C095381:factor V Leiden; D005165:Factor V