title: Left ventricular hypertrophy and its relation to the cardiac kinin-forming system in hypertensive and diabetic rats.
abstract: We investigated the cardiac tissue kallikrein and kininogen levels, left ventricular wall thickness and mean arterial blood pressure of Wistar Kyoto and spontaneously hypertensive rats with and without streptozotocin-induced diabetes. The mean arterial blood pressure was highly elevated (P<0.001) in Wistar Kyoto diabetic and spontaneously hypertensive diabetic rats as compared with their respective controls. The cardiac tissue kallikrein and kininogen levels were reduced significantly (P<0.001) in diabetic Wistar Kyoto, spontaneously hypertensive and diabetic spontaneously hypertensive compared with Wistar Kyoto control rats. In addition, the left ventricular thickness was found to be increased (P<0.001) in diabetic Wistar Kyoto and spontaneously hypertensive rats in the presence and in the absence of diabetes. Our results indicate that reduced activity of the kinin-forming system may be responsible for inducing left ventricular hypertrophy in the presence of raised mean arterial blood pressure in diabetic and hypertensive rats. Thus, the kinin-forming components might have a protective role against the development of left ventricular hypertrophy. The possible significance of these findings is discussed.
authors.affiliation: Department of Pharmacology and Physiology, School of Pharmaceutical Sciences, University Science Malaysia, Penang. jnarain@usm.my
authors.forename: J N
authors.initials: JN
authors.lastname: Sharma
authors.forename: K
authors.initials: K
authors.lastname: Uma
authors.forename: A P
authors.initials: AP
authors.lastname: Yusof
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology*; D004195:Disease Models, Animal; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000503:physiopathology*; D016234:Kallikrein-Kinin System / Q000502:physiology*; D007610:Kallikreins / Q000032:analysis; D007705:Kinins / Q000032:analysis; D008297:Male; D009206:Myocardium / Q000737:chemistry; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013311:Streptozocin
chemical_list: D007705:Kinins; D013311:Streptozocin; D007610:Kallikreins