[Gelatin allergy].
Allergy to the gelatin used as a plasma filler product has not been recognised until now. Methods used have not been validated but are composed of specific serum IgE, skin tests and histamine release by leucotrienes. The clinical observation that we report has the merit of showing the reality of an allergy that is dependent on plasma filler products due to development of a protocol which includes firstly, during anaphylactic shock, measurement of the mediators of immediate hypersensitivity and secondly, after the clinical accident, test of the activation of basophils by flow cytometry (TAB) and measurement of leucotrienes.
Hassoun
S
S
Laboratoire d'Immuno-Allergologie-CHU, Angers, France.
Sabbah
A
A
D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy; D053818:Chymases; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D005780:Gelatin / Q000009:adverse effects*; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D008761:Methylhistamines / Q000652:urine; D010952:Plasma Substitutes / Q000009:adverse effects*; D012697:Serine Endopeptidases / Q000097:blood; D012882:Skin Tests; D053802:Tryptases
D008761:Methylhistamines; D010952:Plasma Substitutes; D007073:Immunoglobulin E; D005780:Gelatin; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases; D004837:Epinephrine
Allergie aux gélatines.