title: Diabetes mellitus, hyperadrenocorticism, and hypothyroidism in a dog.
abstract: An unusual combination of three endocrinopathies found in one dog is described. A six-year-old, spayed female, mixed-breed dog presented with polyuria, polydipsia, polyphagia, and weight loss. She was diagnosed with diabetes mellitus but was suspected of having insulin resistance and was diagnosed subsequently with hyperadrenocorticism. Persistent hypercholesterolemia led to the suspicion and eventual diagnosis of hypothyroidism. The dog has responded well to medical therapy, and her clinical signs and biochemical changes have resolved. A literature search did not identify a similar-reported polyendocrinopathy.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Hess
authors.forename: C R
authors.initials: CR
authors.lastname: Ward
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D007336:Insulin, Isophane / Q000627:therapeutic use; D008939:Mitotane / Q000627:therapeutic use; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007004:Hypoglycemic Agents; D007336:Insulin, Isophane; D008939:Mitotane; D013974:Thyroxine