Absence of human herpesvirus 8 DNA sequences in vascular tumors of the liver.
Kaposi's sarcoma-associated herpes virus (KSHV), also designated human herpesvirus 8 (HHV8), has been detected consistently in Kaposi's sarcoma, body cavity lymphoma and multicentric Castleman's disease, both in human immunodeficiency virus (HIV)-positive and -negative patients. Identification of KSHV/HHV8 DNA sequences in various benign and malignant vascular tumors in HIV-negative patients was reported in one study, but was not confirmed in several other studies. The vascular lesions, other than Kaposi's sarcoma, in which sequences could not be detected have included malignant vascular tumors of serous membranes, infantile capillary hemangiomas, and several benign and malignant vascular tumors of the spleen. We studied 30 primary benign and malignant vascular tumors of the liver; KSHV/HHV8 DNA sequences could not be detected in any. We conclude that this virus plays no role in the etiology of vascular tumors of the liver.
Ishak
K G
KG
Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Bijwaard
K E
KE
Makhlouf
H R
HR
Taubenberger
J K
JK
Lichy
J H
JH
Goodman
Z D
ZD
D000328:Adult; D002648:Child; D004279:DNA, Viral / Q000032:analysis*; D004587:Electrophoresis, Agar Gel; D006391:Hemangioma / Q000473:pathology / Q000821:virology*; D006394:Hemangiosarcoma / Q000473:pathology / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction
D004279:DNA, Viral