title: Technetium-99m-ECD SPECT fails to show focal hyperemia of acute herpes encephalitis.
abstract: This is a case of herpes simplex encephalitis (HSE) examined with 99mTc-ethyl cysteinate dimer (ECD) and 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT. Static images obtained with 99mTc-ECD showed a reduced tracer uptake of the temporal lobe but focal hyperactivity using 99mTc-HMPAO. Dynamic images indicated regional increase of cerebral blood perfusion with both tracers. Technetium-99m-ECD had rapid washout from the inflamed tissue, while 99mTc-HMPAO had avid uptake. Hypofixation of 99mTc-ECD leads to failure to detect the characteristic finding of temporal lobe hyperemia in acute HSE.
authors.affiliation: Department of Neurology, MR Institute, Graz, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Fazekas
authors.forename: G
authors.initials: G
authors.lastname: Roob
authors.forename: F
authors.initials: F
authors.lastname: Payer
authors.forename: P
authors.initials: P
authors.lastname: Kapeller
authors.forename: S
authors.initials: S
authors.lastname: Strasser-Fuchs
authors.forename: R M
authors.initials: RM
authors.lastname: Aigner
mesh_terms: D000208:Acute Disease; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D003545:Cysteine / Q000031:analogs & derivatives*; D018792:Encephalitis, Viral / Q000000981:diagnostic imaging* / Q000821:virology; D005260:Female; D006561:Herpes Simplex / Q000000981:diagnostic imaging*; D006801:Humans; D006940:Hyperemia / Q000000981:diagnostic imaging; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; C059659:technetium Tc 99m bicisate; D003545:Cysteine