title: GABA(A)-receptor assembly in vivo: lessons from subunit mutant mice.
abstract: The rules governing the assembly of GABA(A) receptors in vivo were assessed in subunit mutant mice. The transcription of individual subunit genes was regulated independently. The lack of a particular subunit did not result in a molecular rescue by an enhanced transcription of other subunits. In addition, the availability of an alpha- and beta-subunit was essential for receptor formation. Finally, highly selective recognition processes directed the subcellular targeting of receptors. The loss of a particular receptor subtype (alpha5) did not lead to a subcellular redistribution of the remaining subtype (alpha2) present in the same cell.
authors.affiliation: Institute of Pharmacology, Federal Institute of Technology (ETH) and University of Zürich, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Mohler
authors.forename: B
authors.initials: B
authors.lastname: Luscher
authors.forename: J M
authors.initials: JM
authors.lastname: Fritschy
authors.forename: D
authors.initials: D
authors.lastname: Benke
authors.forename: J
authors.initials: J
authors.lastname: Benson
authors.forename: U
authors.initials: U
authors.lastname: Rudolph
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D051379:Mice; D008817:Mice, Mutant Strains; D011499:Protein Processing, Post-Translational; D011963:Receptors, GABA-A / Q000096:biosynthesis* / Q000145:classification / Q000235:genetics
chemical_list: D011963:Receptors, GABA-A