Repair, reconstruction, regeneration and rehabilitation strategies to spinal cord injury.
The structural changes seen in the transected spinal cord followed by transplantation of the distal ends (neuroma) of intercostal nerve inserted into the spinal cord proximal and distal to the transection lesion site. This activates CNS axonal regeneration. 2,3,4 These changes refer to the plasticity in the nervous system following damage to the spinal cord. There is regeneration and growth and synapotogenesis and remodeling of synaptic connections, development of reflex activity in the denervated cord. Nerve growth factors and neurotrophic factors sustain and maintain a degree of functional integrity of structural neural circuitry. 2,3,4,13 The end result is standing, stepping, and reflex walking in 28 female mature dogs. 2,3,4,5 Electrical stimulation of the anastomosed intercostal nerves resulted in hind limb movements and recording of the electromyograms of the contracting muscles. Twenty-six control dogs and animals with behavioral depression are unable to follow rehabilitative procedures developed muscle atrophy, ankylosis of joints, decrease in bone density, decrease in reflex activity of the spinal cord distal to the transection. 2,3,4,5
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Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA.
D000818:Animals; D001369:Axons / Q000502:physiology; D004285:Dogs; D005260:Female; D007367:Intercostal Nerves / Q000637:transplantation*; D009416:Nerve Regeneration; D013116:Spinal Cord / Q000601:surgery*; D013119:Spinal Cord Injuries / Q000534:rehabilitation / Q000601:surgery*