[TSG101 and breast cancer: a correctly named tumor-suppressor gene?].
In January 1997, PCR genomic analysis of the TSG101 gene showed frequent large intragenic deletions. The investigators used a small cohort of sporadic breast cancers. Li et al. proposed human TSG101 as a breast tumor suppressor gene. Since then, several teams have worked on large series of breast cancers, using a variety of techniques. They have shown that intragenic deletion, if it exists at all, is rare. Is TSG101 a tumor gene or an impostor?
Bénard
J
J
Département de biologie clinique, Institut Gustave-Roussy, Villejuif.
Ahomadégbé
J C
JC
D001943:Breast Neoplasms / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D056827:Endosomal Sorting Complexes Required for Transport; D005260:Female; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D014157:Transcription Factors / Q000235:genetics*; D000099177:Tsg101 Protein
D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D014157:Transcription Factors; D000099177:Tsg101 Protein
TSG101 et cancer du sein: un gène suppresseur de tumeur bien nommé?