[Lipid peroxidation in thyroid tissue of people with diffuse toxic goiter].
The processes of lipids free-radical oxidation in euthyroid and thyrotoxic tissue samples of human thyroid gland were studied. It was shown, that the content of TBA-active lipid peroxidation products was considerably increased in thyrotoxic tissue of the thyroid, and the activity of antioxidant enzymes (catalase, glutation peroxidase) was decreased in it. Possible mechanism of the tissue lipoperoxide alternation under conditions of the thyroid hyperfunction is discussed.
Rom-Boguslavskaia
E S
ES
Ukrainian Research Institute of Pharmacotherapy of Endocrine Diseases, Kharkov State University, Ukraine.
Somova
E V
EV
Ovsiannikova
T N
TN
Diageleva
E A
EA
Karachentsev
Iu I
IuI
Asaula
V A
VA
D002374:Catalase / Q000032:analysis; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000032:analysis; D006111:Graves Disease / Q000097:blood / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D013961:Thyroid Gland / Q000201:enzymology / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D005609:Free Radicals; D017392:Thiobarbituric Acid Reactive Substances; D014284:Triiodothyronine; D002374:Catalase; D005979:Glutathione Peroxidase; D013974:Thyroxine
Peroksidnoe okislenie lipidov v tkani shchitovidnoĭ zhelezy liudeĭ, bol'nykh diffuznym toksicheskim zobom.