[Clinical findings in individuals with the factor V Leiden mutation].
Leiden mutation of the coagulation factor V is the most frequent known congenital risk factor of thrombophilia. The authors examined a group of 440 subjects with thrombosis in the case- or family-history. The mutation was found in 146. In 94 thrombotic manifestations were recorded in the case-history, five women were examined because of repeated abortions. 52.74% carriers of FVL had venous thrombosis of the lower extremities and pelvis in their case-history, 19.18% had pulmonary embolism in the case-history. In 27.40% during the initial manifestations of thrombosis no other risk factor of thrombosis was detected. In 10.27% the first thrombosis developed after an injury or operation. In 22.22% women the thrombosis was manifested during pregnancy or the puerperal period. Due to the high incidence of this defect screening of the resistance to activated protein C should be an integral part of examination of thrombophil conditions.
Matýsková
M
M
Oddĕlení klinické hematologie FNsP, Brno-Bohunice.
Vorlová
Z
Z
Hrachovinová
I
I
Buliková
A
A
Zavrelová
J
J
Slechtová
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D019851:Thrombophilia / Q000235:genetics; D013927:Thrombosis / Q000235:genetics*
D005165:Factor V
Klinické nálezy u jedinců s Leidenskou mutací faktoru V.