title: Complications associated with transcatheter arterial embolization for hepatic tumors.
abstract: Transcatheter arterial embolization (TAE) is widely used in the treatment of hepatic tumors. A total of 2,300 TAE procedures were performed with a 2-15-mL injection of a mixture or suspension of anticancer drugs and iodized oil, followed by administration of gelatin sponge particles. One or two chemotherapeutic drugs, including doxorubicin hydrochloride (10-30 mg), epirubicin hydrochloride (10-30 mg), mitomycin C (10-20 mg), and cisplatin (25-100 mg), were used for each procedure. Complications were encountered in 4.4% of cases (n = 102) and were related to the use of chemoembolic agents or the manipulation of a catheter or guide wire. These complications included acute hepatic failure (n = 6), liver infarction (n = 4) or abscess (n = 5), intrahepatic biloma (n = 20), multiple intrahepatic aneurysms (n = 6), cholecystitis (n = 7), splenic infarction (n = 2), gastrointestinal mucosal lesions (n = 5), pulmonary embolism or infarction (n = 4), tumor rupture (n = 1), variceal bleeding (n = 3), and iatrogenic dissection (n = 35) or perforation (n = 4) of the celiac artery and its branches. Knowledge of these complications is important for correct diagnosis and appropriate management.
authors.affiliation: Department of Radiology, Nagasaki University School of Medicine, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Sakamoto
authors.forename: N
authors.initials: N
authors.lastname: Aso
authors.forename: K
authors.initials: K
authors.lastname: Nagaoki
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: M
authors.initials: M
authors.lastname: Uetani
authors.forename: K
authors.initials: K
authors.lastname: Ashizawa
authors.forename: S
authors.initials: S
authors.lastname: Iwanaga
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Morikawa
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: N
authors.initials: N
authors.lastname: Matsunaga
mesh_terms: D000792:Angiography; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000009:adverse effects*; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage / Q000009:adverse effects*; D006499:Hepatic Artery; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000628:therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D007459:Iodized Oil