The search for orally active medications through combinatorial chemistry.
The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug-like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability.
Fecik
R A
RA
Department of Medicinal Chemistry, Kansas University, Lawrence 66045-2506, USA.
Frank
K E
KE
Gentry
E J
EJ
Menon
S R
SR
Mitscher
L A
LA
Telikepalli
H
H
D000284:Administration, Oral; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D010599:Pharmacokinetics; D013329:Structure-Activity Relationship