Involvement of nitric oxide synthase in proteinuria associated with chronic renal disease in rats.
The present study demonstrates that the nitric oxide synthase inhibitor, aminoguanidine, can attenuate the proteinuria observed in a predominantly noninflammatory model of chronic renal disease in the rat. These data suggest that nitric oxide synthase may be involved in progressive renal disease.
Brooks
D P
DP
Department of Renal Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939, USA.
Contino
L C
LC
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004791:Enzyme Inhibitors; D006146:Guanidines / Q000494:pharmacology; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000201:enzymology* / Q000652:urine; D008297:Male; D009392:Nephrectomy; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011507:Proteinuria / Q000201:enzymology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004791:Enzyme Inhibitors; D006146:Guanidines; D003404:Creatinine; D019001:Nitric Oxide Synthase; C004479:pimagedine