title: Short-term effect of winter air pollution on respiratory health of asthmatic children in Paris.
abstract: There is controversy as to whether low levels of air pollution affect the symptoms and lung function in asthma. We addressed this by examining the short-term effects of winter air pollution on childhood asthma in Paris. We performed a 6 month follow-up of 84 medically diagnosed asthmatic children classified into two groups of severity. The outcomes included incidence and prevalence of asthma attacks, symptoms and use of supplementary beta2-agonists, peak expiratory flow (PEF) value and its variability. The statistical analysis controlled the lack of independence between daily health outcomes, trends and meteorology. Air pollution was associated with an increase in reports and duration of asthma attacks and asthma-like symptoms in mild asthmatic children. The strongest association was the risk of asthma attack for an increase of 50 microg x m(-3) of sulphur dioxide (SO2) on the same day (odds ratio (OR)=2.86). Maximum reduction in morning peak expiratory flow (PEF) (5%) and maximum increase in PEF variability (2%) were observed at a lag of 3 days for an increase of 50 microg x m(-3) of SO2 in the subgroup of mild asthmatics receiving no regular inhaled medication. In moderate asthmatic children, the duration of supplementary beta2-agonist use was strongly associated with air pollution. The general pattern of our results provides evidence of the effect of the low levels of air pollution encountered in Western Europe on symptoms and lung function in childhood asthma.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 408, Epidémiologie, Faculté de Médecine, Bichat, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Segala
authors.forename: B
authors.initials: B
authors.lastname: Fauroux
authors.forename: J
authors.initials: J
authors.lastname: Just
authors.forename: L
authors.initials: L
authors.lastname: Pascual
authors.forename: A
authors.initials: A
authors.lastname: Grimfeld
authors.forename: F
authors.initials: F
authors.lastname: Neukirch
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D000393:Air Pollutants / Q000009:adverse effects; D000397:Air Pollution / Q000009:adverse effects*; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D010297:Paris / Q000453:epidemiology; D010366:Peak Expiratory Flow Rate; D015995:Prevalence; D012621:Seasons; D013458:Sulfur Dioxide / Q000009:adverse effects
chemical_list: D000318:Adrenergic beta-Agonists; D000393:Air Pollutants; D018927:Anti-Asthmatic Agents; D013458:Sulfur Dioxide