[Co-localization of substance P and NADPH-d in the thoracic spinal cord of rabbits].
In this study we have demonstrated the localization of substance P (SP) and nitric oxide (NO), in the thoracic spinal cord of rabbit. SP was concentrated in the dorsal horn of the spinal cord, mostly in the superficial layers (LI, LII), around the central canal (LX), and in the region of intermedia-lateral nucleus (IML nc.). NADPH-d (nicotinamide adenine dinucleotide phosphate diaphorase) is an enzyme, which proves the presence of NO. The highest concentration of NADPH-d positive structures were found in the same regions as the SP-positivity. SP is suggested to play a role in the nociceptive transmission. Localization of NADPH-d revealed also the fact that NO may be involved in nociceptive transmission in the spinal cord. Close association of sympathetic preganglionic neurons and fibers with SP and NADPH-d positive structures suggest a role of these neurotransmitters in the modulation of sympathetic activity. (Fig. 11, Ref. 18.)
Rybárová
S
S
Ustav anatómie Lekárskej fakulty UPJS v Kosiciach, Slovakia.
Kluchová
D
D
Schmidtová
K
K
Dorko
F
F
D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009252:NADPH Dehydrogenase / Q000032:analysis*; D009569:Nitric Oxide / Q000032:analysis; D011817:Rabbits; D013116:Spinal Cord / Q000737:chemistry*; D013373:Substance P / Q000032:analysis*
D009569:Nitric Oxide; D013373:Substance P; D009252:NADPH Dehydrogenase
Kolokalizácia SP a NADPH-d v hrudníkovej mieche králika.