title: [Positive effects of essential phospholipids and improvement of life style in patients with toxic liver injury].
abstract: Within an open, non-randomized clinical study, the authors investigated the effect of a three-month therapy by a standard product of so-called essential phospholipids in a group of patients (31 men and 2 women, average age being 45.6 +/- 10.8 years) with toxic liver damage--steatosis and steatohepatitis which have developed after exposure to the polychlorinated phenols and cresols, or other potentially toxic chemical substances occurring in working environment and/or exposition to alcohol. The therapy included a recommended change in life routine with a decrease in alcohol consumption, or entire exclusion of alcohol abuse. Within the process of observation, the authors used non-invasive methods (clinical examinations, laboratory examinations, ultrasonographic examination). A special attention was paid to the evaluation of the biotransformation capacity the liver and the assessment of spartein-debrisoquin-dextromethorphan metabolic fenotype. The results of investigation indicated: (1) significant improvement of the subjective status of the treated patients associated with an improvement of ultrasonographic findings of liver steatosis, trend of withdrawal of biochemical activity indices and favourable development of the biotransformation capacity of the liver in a majority of the investigated patients. (2) A very good tolerance of the administered drug without adverse effects. The use of non-invasive surrogate markers in coincidence with clinical investigation of the effect of applied medicamentous therapy in patients with chronic liver diseases represents a methodic increase in current modest options of evaluation of effectively and safety of the new therapeutic procedures in clinical hepato-pharmacology. (Tab. 5, Ref. 42.)
authors.affiliation: Subkatedra klinickej farmakológie Institútu pre dalsie vzdelávanie pracovníkov v zdravotníctve v Bratislave, Slovakia.
authors.forename: J
authors.initials: J
authors.lastname: Holomán
authors.forename: J
authors.initials: J
authors.lastname: Glasa
authors.forename: I
authors.initials: I
authors.lastname: Hlavatý
authors.forename: M
authors.initials: M
authors.lastname: Veningerová
authors.forename: V
authors.initials: V
authors.lastname: Prachar
authors.forename: M
authors.initials: M
authors.lastname: Lukácsová
mesh_terms: D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000628:therapy*; D005234:Fatty Liver / Q000139:chemically induced / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000628:therapy*; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D013695:Temperance
chemical_list: D010713:Phosphatidylcholines; C011246:essential 303 forte
vernacular_title: Priaznivý vplyv "esenciálnych fosfolipidov" a úpravy zivotosprávy u pacientov s toxickým poskodením pecene.