title: [The behavioral characteristics of rats induced by partial degeneration of the hippocampal cholinergic neurons].
abstract: The effects of intraventricular administration of ethylcholine aziridinium ion (AF64A) were studied in male Wistar rats. Bilateral injections of AF64A (3 nm/3 mcl) reduced the reactions to biological alarm signal and produced a decrease in the open-field activity 3 weeks after this lesion. The lesioned rats also displayed deficit in retention of a passive avoidance task.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
authors.forename: M G
authors.initials: MG
authors.lastname: Aĭrapetiants
authors.forename: N N
authors.initials: NN
authors.lastname: Shuĭkin
authors.forename: I P
authors.initials: IP
authors.lastname: Levshina
mesh_terms: D000818:Animals; D001388:Aziridines / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D005108:Extinction, Psychological / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009410:Nerve Degeneration / Q000139:chemically induced / Q000503:physiopathology*; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*
chemical_list: D001388:Aziridines; D011950:Receptors, Cholinergic; C044894:ethylcholine aziridinium; D002794:Choline
vernacular_title: Osobennosti povedeniia krys, vyzvannye chastichnoĭ degeneratsieĭ kholinergicheskikh neĭronov gippokampa.