title: Multiple epigenetic events regulate mating-type switching of fission yeast.
abstract: Two epigenetic events at mat1, one of which is DNA strand specific, are required to initiate recombination during mating-type switching. The third, a chromosomally borne imprinted event at the mat2/3 interval regulates silencing and directionality of switching, and prohibits interchromosomal recombination. We speculate that the unit of inheritance in the mat2/3 interval is both DNA plus its associated chromatin structure. Such a control is likely to be essential in maintaining particular states of gene expression during development.
authors.affiliation: National Cancer Institute-Frederick Cancer Research, Frederick, MD 21702-1201, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Klar
authors.forename: A V
authors.initials: AV
authors.lastname: Ivanova
authors.forename: J Z
authors.initials: JZ
authors.lastname: Dalgaard
authors.forename: M J
authors.initials: MJ
authors.lastname: Bonaduce
authors.forename: S I
authors.initials: SI
authors.lastname: Grewal
mesh_terms: D000818:Animals; D015825:Chromosomes, Fungal; D004271:DNA, Fungal; D005785:Gene Conversion; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D049770:Genes, Mating Type, Fungal; D018392:Genomic Imprinting; D009363:Neoplasm Proteins / Q000235:genetics; D011995:Recombination, Genetic; D012568:Schizosaccharomyces / Q000235:genetics*
chemical_list: D004271:DNA, Fungal; D009363:Neoplasm Proteins