title: Rheumatoid arthritis--a review.
abstract: Rheumatoid arthritis, a common chronic inflammatory arthritis, tends to run a more benign course in patients from the community than those seen at hospitals. The aetiology is unknown but the disease is postulated to result from the interaction between genetic and environmental factors. The strongest genetic association is with the major histocompatibility complex (MHC) Class II antigen HLA DR 4, although not more than 50% of the genetic susceptibility is due to MHC genes. In early disease the pathogenesis is thought to be T cell mediated whereas in late disease the mechanisms are T cell independent, with destruction contributed to by autonomous fibroblast like synoviocytes. The diagnosis is made on clinical groups. Management is directed at controlling active synovitis so that joint damage is limited. The early use of a slow acting anti-rheumatic drug is now advocated, as studies have shown that they can potentially prevent or limit the progression of disease. Biological therapies are still experimental but may hold promise for the future.
authors.affiliation: Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
authors.forename: H S
authors.initials: HS
authors.lastname: Howe
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000628:therapy*; D004359:Drug Therapy, Combination; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D008297:Male; D026741:Physical Therapy Modalities / Q000379:methods; D011379:Prognosis
chemical_list: D018501:Antirheumatic Agents