Influence of endotoxin on the level of tumor necrosis factor alfa and blood morphology in rats.
The influence of endotoxin E.coli O127 B:8 given intravenously or intraperitoneally on the level of Tumor Necrosis Factor alfa (TNF-alpha), blood cells count and bone marrow morphology in rats was studied. The presented results show that endotoxin (3 mg/kg) given intravenously or intraperitoneally (1 or 3 times) provoked an appearance of TNF-alpha in the systemic circulation 24 hours after its injection. Endotoxin given intravenously evoked greater changes in blood morphology and bone marrow than that applicated intraperitoneally.
Hryniewicz
A
A
Department of Clinical Physiology, Medical Academy of Białystok.
Kozłowska
H
H
Hołownia
E
E
Kemona
A
A
Poczopko
B
B
Dziecioł
J
J
Puch
U
U
D000818:Animals; D001772:Blood Cell Count; D001773:Blood Cells / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D004487:Edema / Q000473:pathology; D004731:Endotoxins / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D004804:Eosinophils / Q000473:pathology; D004926:Escherichia coli / Q000145:classification; D006940:Hyperemia / Q000473:pathology; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007958:Leukocyte Count; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood; D018655:Lymphocyte Count; D008297:Male; D009000:Monocytes / Q000473:pathology; D009336:Necrosis; D009504:Neutrophils / Q000473:pathology; D010976:Platelet Count; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D004731:Endotoxins; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha