[The hormone-metabolic changes in the diabetic angiopathy].
Biochemical, morphological and electron-microscopic readings of blood serum, liver, aorta and brain vessels, and in crystalline lens were investigated in intact and experimental animals during the process of experimental diabetes mellitus formation. The experimental diabetes mellitus was induced by L-adrenaline implementation and atherogenous load. Characteristics of lipid metabolism, peroxide lipid oxidation, sorbitol way of glucose metabolism, glucose and insulin levels conform to diabetes mellitus. Diabetic lipid metabolism impairments were accompanied with changes in microcirculation--a cause of diabetes mellitus complications. These data were supported by morphological and electron-microscopic readings. The results of the study confirm the hormone hypothesis of diabetic complications and stress (high adrenaline level) factors of Diabetes Mellitus pathogenesis.
Tat'ianenko
L V
LV
Institute of Chemical Physics of Russian Academy of Sciences, Chernogolovka, Moscow Reqion.
Shaposhnikova
G I
GI
Gulevskaia
T S
TS
Smirnov
L D
LD
D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000473:pathology; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000378:metabolism* / Q000473:pathology; D004036:Diet, Atherogenic; D004837:Epinephrine / Q000008:administration & dosage; D007328:Insulin / Q000378:metabolism*; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D004837:Epinephrine
Gormonal'no-metabolicheskie sdvigi pri vozniknovenii diabeticheskikh angiopatiĭ.