title: The prevalence and effect of alcohol and drug abuse on cohort-matched critically injured patients.
abstract: A prospective study was undertaken at a Level I trauma center to evaluate the prevalence of substance use among victims of major trauma, along with the impact on clinical outcome. Five hundred sixteen patients had urine toxicology and blood alcohol screens performed and correlated with pattern and severity of injury, hospital course, and outcome. Three hundred seventy-one patients (71%) screened positive for alcohol or drugs, or both. Fifty-two per cent had positive alcohol screens, and 42 per cent had positive drug screens (cocaine and opiates represented 91% of positive drug screens). Univariate analysis revealed patterns of alcohol/drug use varied among subgroups according to demographics (less use among patients older than 55 years, females and Asians; more drug use in blacks; more alcohol use in Hispanics), mechanism of injury (non-use in blunt trauma patients and use of both in penetrating trauma patients) and body region injured (non-use in head-injured patients). Septic complications and mortality were more correlative with severity of injury, but not with use or non-use of alcohol or drugs. We conclude that alcohol and drug use remains a major comorbid factor in major trauma, and that injury prevention efforts should include a strong focus on counseling regarding these lifestyle choices.
authors.affiliation: Department of Surgery, University of Southern California Medical Center, Los Angeles, USA.
authors.forename: E E
authors.initials: EE
authors.lastname: Cornwell
authors.forename: H
authors.initials: H
authors.lastname: Belzberg
authors.forename: G
authors.initials: G
authors.lastname: Velmahos
authors.forename: L S
authors.initials: LS
authors.lastname: Chan
authors.forename: D
authors.initials: D
authors.lastname: Demetriades
authors.forename: B M
authors.initials: BM
authors.lastname: Stewart
authors.forename: D B
authors.initials: DB
authors.lastname: Oder
authors.forename: D
authors.initials: D
authors.lastname: Kahaku
authors.forename: D
authors.initials: D
authors.lastname: Chan
authors.forename: J A
authors.initials: JA
authors.lastname: Asensio
authors.forename: T V
authors.initials: TV
authors.lastname: Berne
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000150:complications / Q000453:epidemiology*; D015897:Comorbidity; D003422:Critical Care; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000453:epidemiology* / Q000601:surgery; D011379:Prognosis; D011446:Prospective Studies; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000150:complications / Q000453:epidemiology*