title: Mitochondrial myopathies--a clinicopathological study.
abstract: Mitochondrial myopathies are heterogeneous group of clinical disorders that can affect multiple systems besides skeletal muscles. The mitochondrial abnormalities in the skeletal muscles are morphologically identified by the presence of characteristic Ragged-red fibers (RRF) in the cryostat sections of the muscle stained with modified Gomori's trichrome stain. In this retrospective study, clinical and histopathological features in six patients with mitochondrial myopathies have been analysed. The utility of histochemical methods in confirming the diagnosis of mitochondrial myopathy has been emphasised.
authors.affiliation: Department of Pathology, Sree Chitra Tirunal Institute for Medical Science & Technology, Kerala.
authors.forename: V V
authors.initials: VV
authors.lastname: Radhakrishnan
authors.forename: A
authors.initials: A
authors.lastname: Saraswathy
authors.forename: N S
authors.initials: NS
authors.lastname: Radhakrishnan
authors.forename: M D
authors.initials: MD
authors.lastname: Nair
authors.forename: A
authors.initials: A
authors.lastname: Kuruvilla
authors.forename: K
authors.initials: K
authors.lastname: Radhakrishnan
mesh_terms: D000293:Adolescent; D000328:Adult; D004801:Eosine Yellowish-(YS); D005260:Female; D006416:Hematoxylin; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000648:ultrastructure*; D017240:Mitochondrial Myopathies / Q000201:enzymology / Q000473:pathology*; D018656:Muscle Fibers, Fast-Twitch / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D009246:NADH Tetrazolium Reductase / Q000032:analysis; D013194:Staining and Labeling
chemical_list: D009246:NADH Tetrazolium Reductase; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin