[Mathematical modeling of energy coupling in mitochondria in frames of proton-chemical hypothesis].
The dependence of ATP-synthesis and mitochondria respiration rates on membrane potential was analyzed in frames of proton-chemical hypothesis of oxidative phosphorylation. The mathematical and electrical models of the unit of energy coupling are proposed. Computer analysis of the mathematical model allowed to obtain the theoretical dependence of the rates of ATP synthesis and of the respiration on the membrane potential. Both of all are in good qualitative agreement with experimental data, contradicting chemiosmotic hypothesis.
Lemeshko
V V
VV
Research Institute of Biology, Khar'kov State University, Ukraine.
Anishkin
A G
AG
D000818:Animals; D004579:Electron Transport; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D008962:Models, Theoretical; D010085:Oxidative Phosphorylation
Matematicheskoe modelirovanie energeticheskogo sopriazheniia v mitokhondriiakh v ramkakh protonno-chimicheskoĭ gipotesy.