Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.
García-Echeverría
C
C
Oncology Research and Core Technology Area, Novartis Pharma Inc., CH-4002 Basel, Switzerland.
Furet
P
P
Gay
B
B
Fretz
H
H
Rahuel
J
J
Schoepfer
J
J
Caravatti
G
G
D048868:Adaptor Proteins, Signal Transducing; D051380:GRB2 Adaptor Protein; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011487:Protein Conformation; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D018909:src Homology Domains
C112415:3-amino-phenylmethoxycarbonyl-phosphotyrosyl-1-aminocyclohexanecarbonyl-asparaginamide; D048868:Adaptor Proteins, Signal Transducing; D051380:GRB2 Adaptor Protein; D008024:Ligands; D009842:Oligopeptides; D011506:Proteins