Influence of tea catechins on the digestive tract.
Tea catechins undergo various metabolic changes after they are taken orally, though a large percentage are excreted intact with the feces. Epidemiological studies suggest a protective effect of tea against various human cancers, including colon and rectum. The bactericidal property of tea catechins plays several roles in the digestive tract. In the small intestine, catechins inhibit alpha-amylase activity, and a certain amount is absorbed into the portal vein. Although catechins are bactericidal, they do not affect lactic acid bacteria. Including tea catechins in the diet for several weeks decreases putrefactive products and increases organic acids by lowering pH. These changes were achieved in tube-fed patients by administering 100 mg of tea catechins (equivalent to a cup of green tea) three times daily with meals for 3 weeks. When catechin administration ceased, the effects reversed after 1 week. Catechins should be considered further in colon carcinogenesis studies.
Hara
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Food Research Institute, Mitsui Norin Co., Ltd., Shizuoka Pref., Japan.
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D004064:Digestive System / Q000187:drug effects*; D004067:Digestive System Neoplasms / Q000517:prevention & control*; D005243:Feces / Q000382:microbiology; D006801:Humans; D007422:Intestines / Q000382:microbiology / Q000502:physiology; D013662:Tea / Q000737:chemistry*
D016588:Anticarcinogenic Agents; D013662:Tea; D002392:Catechin