title: Antiphospholipid antibody syndrome in a case with redo coronary artery bypass grafting under cardiopulmonary bypass.
abstract: A patient who underwent redo coronary artery bypass grafting developed severe thrombocytopenia. A platelet transfusion caused recurrent hypotension and hypoxia. The patient status was complicated by a systemic thrombosis including coronary graft occlusion and central vein thrombosis. We found that the lupus anticoagulant, as well as other autoimmune antibodies, was positive only after the thrombotic episode developed. Even though the lupus anticoagulant returned to negative about 2 months after the episode of graft occlusion, the patient eventually died of heart failure.
authors.affiliation: Department of Cardiovascular Surgery, National Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: K
authors.initials: K
authors.lastname: Kumon
authors.forename: N
authors.initials: N
authors.lastname: Yahagi
authors.forename: M
authors.initials: M
authors.lastname: Haruna
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D016736:Antiphospholipid Syndrome / Q000209:etiology*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003327:Coronary Disease / Q000601:surgery; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis*; D008297:Male; D012086:Reoperation; D013921:Thrombocytopenia / Q000209:etiology; D013927:Thrombosis / Q000209:etiology
chemical_list: D016682:Lupus Coagulation Inhibitor