[Comparative study of the ploidy and cell proliferation of malignant epithelial neoplasms of various origin (flow cytometric assay)].
Flow cytometry was used for measure DNA content of tumor cells of squamous-cell carcinoma of the tongue and mucosa of the oral cavity fundus, invasive ductal breast carcinoma, endometrial, colonic and rectal adenocarcinomas. Frequency of aneuploidy is characteristic of tumor. Frequency of aneuploidy is high in the oral cavity and breast cancer, colonic and rectal carcinomas and low in cancer of the tongue and endometrium Aneuploidy is associated with nonfavorable clinical and morphological signs of breast cancer, carcinomas of the oral cavity, corpurus uteri and rectum. High DNA index is typical of aggressiveness of carcinomas of the tongue, breast and endometrium. High proliferative activity prognostic factor of endometrial adenocarcinoma. We also found aneuploid cells in normal epithelium of the corpurus uteri, colon and rectum of patients with aneuploid tumors of the same organ. It is possible to suggest that these cells is an unfavorable cause recurrence.
Bychkova
N V
NV
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, Center of Emergency and Radiation Medicine, St. Petersburg.
Meshkova
I E
IE
Pozharisskiĭ
K M
KM
D000230:Adenocarcinoma / Q000503:physiopathology; D001943:Breast Neoplasms / Q000503:physiopathology; D018270:Carcinoma, Ductal, Breast / Q000503:physiopathology; D002294:Carcinoma, Squamous Cell / Q000503:physiopathology; D002455:Cell Division; D015179:Colorectal Neoplasms / Q000503:physiopathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D009062:Mouth Neoplasms / Q000503:physiopathology; D009369:Neoplasms / Q000235:genetics / Q000503:physiopathology*; D011003:Ploidies
Sravnitel'noe issledovanie ploidnosti i proliferativnoĭ aktivnosti kletok zlokachestvennykh épitelial'nykh novoobrazovaniĭ razlichnogo proiskhozhdeniia (protochno-tsitometrichenkikh analiz)