title: [Isotopic ventriculography in patients with obstructive hypertrophic cardiomyopathy treated with dual chamber stimulation].
abstract: BACKGROUND
  Dual pacing stimulation improves symptoms and reduces intraventricular pressure gradient in obstructive hypertrophic cardiomyopathy. The mechanisms proposed for these effects are a change in ventricular contraction sequence, a paradoxical movement of the interventricular septum and a reduction in ventricular contractility. However, dual chambers pacing stimulation effects on systolic and diastolic function are unknown, and the study of this is the aim of this work.
  
  
  METHODS
  We performed a radionuclide ventriculography in 10 patients with obstructive hypertrophic cardiomyopathy at 2 days and 1 and 6 months after placing a dual chamber pacemaker. The phase images, ventricular volumes, left ventricular ejection fraction and segmentary contractility were evaluated. Diastolic maximum peak-filling-rate and time to-peak-filling-rate were also studied.
  
  
  RESULTS
  In DDD pacing stimulation, parametric phase images show a reversal up-down contraction sequence starting from the apical segment. At 6 months radionuclide ventriculography, a reduction in ejection fraction was found (60.9 +/- 12 vs 73.4 +/- 9.1; p < 0.05) which was attributed to apical, apical-septum and mainly basal-septum segmentary contraction decrease. A paradoxical mid-systolic septum movement was also found during DDD stimulation. No differences on diastolic parameters were noted.
  
  
  CONCLUSIONS
  During dual chamber stimulation, a reversal ventricular contraction sequence, a paradoxical septum movement, hypokinesis of the septal ventricular segments and a reduction on left ventricular ejection fraction was observed.
authors.affiliation: Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia.
authors.forename: G
authors.initials: G
authors.lastname: de la Morena
authors.forename: J
authors.initials: J
authors.lastname: Martínez
authors.forename: M I
authors.initials: MI
authors.lastname: Castellón
authors.forename: J A
authors.initials: JA
authors.lastname: Valentí
authors.forename: M
authors.initials: M
authors.lastname: Pérez Paredes
authors.forename: J A
authors.initials: JA
authors.lastname: Nuño de la Rosa
authors.forename: J A
authors.initials: JA
authors.lastname: Ruipérez
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial / Q000379:methods; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D015635:Radionuclide Ventriculography
vernacular_title: Ventriculografía isotópica en pacientes con miocardiopatía hipertrófica obstructiva tratados con estimulación bicameral.