[The properties of the benzodiazepine receptors in the rat cerebellum after acute seizures and the development of korazol-induced kindling].
The acute korazol (pentylenetetrazol) injection (50 mg/kg) induced seizures which were accompanied by a long-lasting (from 30 minutes to 3 days) decrease in benzodiazepine receptor (BDR) density (Bmax) in rat cerebellum without change in affinity. The density of the BDR was normalized on the 7th day after seizure termination. There were no differences in the initial BDR characteristics between the animals more sensitive to korazol (a dose of 25 mg/kg was sufficient for seizure induction) and less sensitive (30 mg/kg were ineffective). The chronic daily (for 24 days) administration of korazol in a subconvulsive dose led to an increase in seizure readiness (kindling). In 30 min after the last korazol injection the BDR density was decreased to the same extent as after the acute 50 mg/kg korasol administration. The BDR density was normalized on the 7th day after kindling. It was demonstrated that the high-dose-induced and after-kindling seizures were underlain by the same mechanisms. The results suggest that the development of kindling depends on the state of the long-lasting receptors rather than the development of kindling forms the long-lasting reactions. The process of summation is at the basis of kindling development. The long-lasting decrease in activity of BDR receptors induced by a subconvulsive dose of korazol is summed with the following effect of the same dose.
Bazian
A S
AS
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Zhulin
V V
VV
Karpova
M N
MN
Klishina
N Iu
NIu
Glebov
R N
RN
D000208:Acute Disease; D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D003292:Convulsants / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D013570:Synaptic Membranes / Q000378:metabolism; D013997:Time Factors
D003292:Convulsants; D011963:Receptors, GABA-A; D010433:Pentylenetetrazole
Svoĭstva benzodiazepinovykh retseptorov mozzhechka krys posle ostrykh sudorog i razvitiia korazolovogo kindlinga.