Prescription of cardiovascular drugs in outpatient care: a survey of outpatients in a German university hospital.
OBJECTIVE
We evaluated ambulatory prescriptions by general practitioners for outpatients with cardiovascular (CV) disease referred to the cardiology outpatient clinic of the Frankfurt University Hospital in order to prove adherence to generally acknowledged therapy standards for treating CV disease.


RESULTS
Appropriateness of current CV medication was assessed according to the following criteria: aspirin or anticoagulants obligatory after myocardial infarction (MI), unless contraindicated; beta-blockers should be prescribed after MI, unless contraindicated or not tolerated; ACE inhibitors should be given in left ventricular dysfunction (LVD) after MI, unless contraindicated; and hypertension should be adequately controlled. 346 patients (28-94 years) received a median of 3 CV drug prescriptions (range 0-7). 240 patients had CAD, 142 patients previous MI, 121 patients had LVD (59 after MI), 143 patients were hypertensive. Aspirin was used appropriately in 80% of all MI patients, 13% received oral anticoagulants due to atrial fibrillation. However, 7% received no antithrombotic therapy. ACE inhibitors were administered in 65% of the MI patients with LVD. beta-blockers were used in 25% of the MI-patients. In the remaining patients, beta-blockers were contraindicated, not tolerated, and/or verapamil had been prescribed. However, in 14% of the patients beta-blockers were withheld without evident reason or alternative drug. In 41% of the hypertensive patients, blood pressure was not sufficiently controlled.


CONCLUSIONS
A considerable number of ambulatory prescriptions for CV drugs are not in accordance with current therapeutic guidelines. The role of a cardiology outpatient clinic to detect the misuse or underuse of CV drugs is emphasised.
Harder
S
S
Institute of Clinical Pharmacology, University Hospital, Frankfurt/Main, Germany.
Thürmann
P
P
Thierolf
C
C
Klepzig
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy; D011307:Drug Prescriptions; D004363:Drug Utilization; D005858:Germany; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D010044:Outpatient Clinics, Hospital; D011446:Prospective Studies
D002317:Cardiovascular Agents