title: Leg ulceration with associated thrombocytosis: healing of ulceration associated with treatment of the raised platelet count.
abstract: Thrombocytosis is the cause of various complications in myeloproliferative disorders. We present the case of a 54-year-old woman with chronic myelogenous leukaemia who developed large ulcers on both lower legs that were refractory to standard treatment. As concomitant thrombocytosis persisted despite treatment with hydroxyurea, the new megakaryocyte inhibitor anagrelide (Agrelin) was administered and led to normalization of the platelet count within 11 days. The leg ulcers started to heal after 2 weeks and disappeared over a period of 5 months. Our findings argue for a pathogenic role of platelets in the development of leg ulcers in patients with thrombocytosis due to a myeloproliferative disorder.
authors.affiliation: Department of Haematology/Oncology, Albert-Ludwigs-Universität Freiburg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Wirth
authors.forename: E
authors.initials: E
authors.lastname: Schoepf
authors.forename: R
authors.initials: R
authors.lastname: Mertelsmann
authors.forename: A
authors.initials: A
authors.lastname: Lindemann
mesh_terms: D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000188:drug therapy; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D013922:Thrombocytosis / Q000150:complications* / Q000188:drug therapy
chemical_list: D010975:Platelet Aggregation Inhibitors; D011799:Quinazolines; C021139:anagrelide