title: Parallel-stranded duplexes and quartet assemblies formed by oligonucleotides containing isoguanine.
abstract: Oligonucleotides with isoguanine-cytosine base pairs form duplexes with parallel chain orientation. This strong base pair dictates the strand polarity when additional dA-dT or N7Ad-dT pairs are present. The same is observed for the isocytosine-guanine pair. Quartet structures are built by the self-assembly of oligonucleotides containing short runs of isoguanine or 7-deazaisoguanine. New base pairs between isoguanine or guanine and 5-aza-7-deazaguanine are presented.
authors.affiliation: Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Seela
authors.forename: C
authors.initials: C
authors.lastname: Wei
authors.forename: A
authors.initials: A
authors.lastname: Melenewski
authors.forename: P
authors.initials: P
authors.lastname: Leonard
mesh_terms: D001482:Base Composition; D003596:Cytosine / Q000031:analogs & derivatives; D004355:Drug Stability; D006147:Guanine; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D011743:Pyrimidines; D011758:Pyrroles
chemical_list: C113087:7-deazaisoguanine; D009838:Oligodeoxyribonucleotides; D011743:Pyrimidines; D011758:Pyrroles; C093270:isocytosine; D006147:Guanine; D003596:Cytosine; C008183:isoguanine