title: [Effects of continuous estradiol-progestogen treatment on hemostasis in postmenopausal women].
abstract: A study was undertaken to asses the effects of oral continuous hormone replacement therapy on haemostatic balance. Blood samples were drawn from 28 postmenopausal women (mean age 54.1 +/- 4.1) with severe climacteric complaints. All the women were treated for one year with a continuous oestradiol-progestogen regimen which was administrated daily and consisting of 2 mg 17 beta-oestradiol in combination with norethisteron acetate, 1 mg (Kliogest-Novo-Nordisk). Hormone replacement therapy had no effect on fibrinogen and thrombin time. Activated partial thromboplastin time as well as prothrombin time was significantly decreased (p < 0.05) respectively 1.7 +/- 3.1 s and 0.6 +/- 1.4 s. No women developed crural thrombosis during therapy.
authors.affiliation: Kliniki Endokrynologii Ginekologicznej AM w Warszawie.
authors.forename: S
authors.initials: S
authors.lastname: Radowicki
authors.forename: B
authors.initials: B
authors.lastname: Horoszko-Husiatyńska
authors.forename: M
authors.initials: M
authors.lastname: Kunicki
authors.forename: M
authors.initials: M
authors.lastname: Sieńkowska
mesh_terms: D003266:Continuity of Patient Care; D004958:Estradiol / Q000494:pharmacology* / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D017698:Postmenopause / Q000187:drug effects*; D011372:Progestins / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D011372:Progestins; D004958:Estradiol
vernacular_title: Wpływ ciagłego leczenia substytucyjnego u kobiet pomenopauzalnych na zachowanie sie wybranych wykładników układu krzepniecia krwi.