Duration of growth suppressive effects of regular inhaled corticosteroids.
The growth of 50 children receiving regular inhaled corticosteroids was segregated into divisions of six weeks from the start of treatment and compared with their growth when not receiving regular corticosteroids using a random effects regression model. Growth suppression was most marked during the initial six weeks after starting treatment, with most suppression occurring during the initial 18 weeks. Thereafter the children's growth was similar to their growth when not receiving treatment. These findings have important consequences for patterns of treatment of asthma in children.
Doull
I J
IJ
Department of Child Health, University Hospital of Wales, Heath Park, Cardiff.
Campbell
M J
MJ
Holgate
S T
ST
D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006128:Growth / Q000187:drug effects*; D006801:Humans; D008137:Longitudinal Studies; D012044:Regression Analysis; D013997:Time Factors
D018927:Anti-Asthmatic Agents; D001507:Beclomethasone