title: Influence of bioregulators on the phospholipid Langmuir monolayers.
abstract: Influence of bioregulators on the phospholipid Langmuir monolayers made of distearoylphosphatidylcholine and its equimolar mixture with dimitrystoylphosphatidylcholine was investigated. The results obtained allow concluding that the presence of physiologically active compounds in the subphase weakens the lipid-lipid interaction and increases the free energy change of air-liquid interface in the case of pure distearoylphosphatidylcholine monolayers, but in the case of mixed monolayers it leads both to the increase and decrease of these parameters. Presence of the dimirystoylphosphatidylcholine molecules with the short fatty acyl chains in the monolayer destabilizes it. This effect is partially compensated by the interaction between lipid and subphase molecules.
authors.affiliation: Institute of Bioorganic Chemistry and Oil Chemistry, National Academy of Sciences of Ukraine, Kyiv.
authors.forename: A S
authors.initials: AS
authors.lastname: Mogilevich
authors.forename: S E
authors.initials: SE
authors.lastname: Mogilevich
authors.forename: A L
authors.initials: AL
authors.lastname: Luik
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D018663:Adrenergic Agents / Q000494:pharmacology; D000388:Air / Q000032:analysis; D002021:Buffers; D002725:Chloroform / Q000737:chemistry; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D000276:Adjuvants, Immunologic; D018663:Adrenergic Agents; D002021:Buffers; D006634:Histamine H1 Antagonists; D010276:Parasympatholytics; D010713:Phosphatidylcholines; D014867:Water; D009240:N-Formylmethionine Leucyl-Phenylalanine; D002725:Chloroform; D000255:Adenosine Triphosphate; C010942:1,2-distearoyllecithin; D004134:Dimyristoylphosphatidylcholine