Long-term effect of botulinum toxin on impairment and functional health in cervical dystonia.
We investigated the long-term effect of botulinum toxin type A (BTA) on impairment as well as functional health in terms of disability, handicap, and quality of life in 64 patients with cervical dystonia. These patients, who first participated in a double-blind trial, were followed for another 12 months. Fifty-four patients continued treatment after 12 months of follow-up and showed improvement on all scales. Furthermore, this effectiveness appeared to increase during follow-up, which suggests a cumulative clinical effect of BTA.
Brans
J W
JW
Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands.
Lindeboom
R
R
Aramideh
M
M
Speelman
J D
JD
D001905:Botulinum Toxins / Q000627:therapeutic use*; D004185:Disability Evaluation; D004311:Double-Blind Method; D004421:Dystonia / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D009334:Neck Muscles / Q000187:drug effects*; D011788:Quality of Life; D013997:Time Factors
D001905:Botulinum Toxins