title: The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine.
abstract: The yeast YCC5 gene encodes a putative amino acid permease and is homologous to GNP1 (encoding a high-affinity glutamine permease). Using strains with disruptions in the genes for multiple permeases, we demonstrated that Ycc5 (which we have renamed Agp1) is involved in the transport of asparagine and glutamine, performed a kinetic analysis of this activity, and showed that AGP1 expression is subject to nitrogen repression.
authors.affiliation: Department of Biology, Hamilton College, Clinton, New York 13323, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Schreve
authors.forename: J K
authors.initials: JK
authors.lastname: Sin
authors.forename: J M
authors.initials: JM
authors.lastname: Garrett
mesh_terms: D026905:Amino Acid Transport Systems; D026923:Amino Acid Transport Systems, Basic; D026921:Amino Acid Transport Systems, Neutral; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology; D000641:Ammonia / Q000494:pharmacology; D001216:Asparagine / Q000378:metabolism*; D001692:Biological Transport; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects; D005800:Genes, Fungal; D005973:Glutamine / Q000378:metabolism*; D007700:Kinetics; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins
chemical_list: C420623:AGP1 protein, S cerevisiae; D026905:Amino Acid Transport Systems; D026923:Amino Acid Transport Systems, Basic; D026921:Amino Acid Transport Systems, Neutral; D000600:Amino Acids, Dicarboxylic; D026901:Membrane Transport Proteins; D029701:Saccharomyces cerevisiae Proteins; D005973:Glutamine; D001216:Asparagine; D000641:Ammonia; C051432:glutamine permease