title: Peripheral primitive neuroectodermal tumor presenting with diffuse cutaneous involvement and 7;22 translocation.
abstract: We report an unusual case of peripheral primitive neuroectodermal tumor (pPNET) in an infant presenting with congenital cutaneous nodules and a t(7;22)(p21;q11.2). The biologic behavior of the tumor diverged over time from a slowly growing tumor with multiple cutaneous nodules to a more aggressive neoplasm characterized by pulmonary metastases and a soft tissue mass showing additional cytogenetic alterations.
authors.affiliation: Department of Radiation Oncology, University of Utah Health Sciences Center, Salt Lake City 84132, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Smith
authors.forename: R H
authors.initials: RH
authors.lastname: Adams
authors.forename: A R
authors.initials: AR
authors.lastname: Brothman
authors.forename: S L
authors.initials: SL
authors.lastname: Vanderhooft
authors.forename: C M
authors.initials: CM
authors.lastname: Coffin
mesh_terms: D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007223:Infant; D008297:Male; D018242:Neuroectodermal Tumors, Primitive / Q000235:genetics / Q000473:pathology*; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000235:genetics / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D014178:Translocation, Genetic