Effects of leaf aqueous extract of Bidens pilosa (Asteraceae) on KCl- and norepinephrine-induced contractions of rat aorta.
The effect of leaf aqueous extract of Bidens pilosa Linn. on KCl- and norepinephrine-induced contractions of rat aortic strips was studied. In aortic strips with endothelium intact, contractions induced using 60 mM KCl and 10(-5) M norepinephrine were dose-dependently relaxed by the extract, a more significant effect being seen with norepinephrine-induced contractions. Following mechanical damage to the aortic endothelium, inhibition of contractions was more prominent (105%) with the norepinephrine-induced contractions compared with KCl-induced contractions (15%) when the maximal dose (8 mg/ml) of the extract was used. The results suggest that the relaxation effect of the extract may be due to the blockade of the influx of extracellular Ca2+ into the cell.
Dimo
T
T
Department of Animal Biology and Physiology, Faculty of Sciences, University of Yaounde I, Cameroon.
Rakotonirina
S
S
Kamgang
R
R
Tan
P V
PV
Kamanyi
A
A
Bopelet
M
M
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000502:physiology; D019659:Asteraceae / Q000737:chemistry*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D011189:Potassium Chloride / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D011189:Potassium Chloride; D009638:Norepinephrine