Expression of antimetastatic gene nm23-H1 in epithelial ovarian cancer.
OBJECTIVE
To investigate the expression of nm23-H1 in epithelial ovarian cancer.


METHODS
A total of 55 specimens from patients with epithelial ovarian cancers, 15 patients with serous cancers, 7 with mucinous cancers, 17 with endometrioid cancers and 16 with adenocarcinomas, were examined for the expression of nm23-H1 by means of the immunohistochemical technique.


RESULTS
The total positive rate was 23.64% (13/55). The tissular nm23-H1 immunostaining had significantly higher expression in mucinous cancer (57.14%) than in other histologic types of epithelial ovarian cancer (P < 0.05). Compared to that in the primary tumor, nm23-H1 expression in the omental metastatic tumor in the same patient was reduced.


CONCLUSIONS
The expression rate of nm23-H1 is higher in the primary tumors than in the metastatic tumors and is different in various histologic subtypes of epithelial ovarian cancer. The expression of nm23-H1 may participate in the inhibitory process of tumor invasion.
Qian
M
M
Department of Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical University, China.
Feng
Y
Y
Xu
L
L
Zheng
S
S
Zhou
X
X
D000230:Adenocarcinoma / Q000235:genetics; D018269:Carcinoma, Endometrioid / Q000235:genetics*; D018282:Cystadenocarcinoma, Mucinous / Q000235:genetics*; D018284:Cystadenocarcinoma, Serous / Q000235:genetics; D005260:Female; D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D006801:Humans; D008207:Lymphatic Metastasis; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D010051:Ovarian Neoplasms / Q000235:genetics*; D014157:Transcription Factors / Q000096:biosynthesis*
D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins