title: Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.
abstract: Kainate receptors were present at birth in the murine somatosensory cortex as revealed by quantitative in vitro autoradiography. During the first five postnatal days [3H]kainate binding rapidly increased and the maximum density in layer IV was reached at P12. The adult laminar pattern of receptor binding distribution was established by the third postnatal week with the heaviest labeling of infragranular layers. The sharp increase of kainate receptor during the first postnatal week coincides with the critical period for cytoarchitectonic plasticity of the barrels and establishment of functional thalamo-cortical connections in the barrel field.
authors.affiliation: Department of Neurophysiology, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland. beataja@nencki.gov.pl
authors.forename: B
authors.initials: B
authors.lastname: Jabłońska
authors.forename: A L
authors.initials: AL
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Kossut
authors.forename: J
authors.initials: J
authors.lastname: Skangiel-Kramska
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D001931:Brain Mapping; D008297:Male; D051379:Mice; D009473:Neuronal Plasticity / Q000502:physiology; D018092:Kainic Acid Receptors / Q000032:analysis*; D013003:Somatosensory Cortex / Q000737:chemistry* / Q000254:growth & development
chemical_list: D018092:Kainic Acid Receptors