title: Levels of proteins C and S do not decline subsequent to first line chemotherapy in lymphoma patients.
abstract: Thromboembolic complications and decrease in protein C and S have been observed in patients while receiving combination chemotherapy for breast cancer. We investigated whether initial cytotoxic treatment of non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) is also associated with changes in these anticoagulant parameters. For this purpose 25 patients with intermediate to high grade NHL and seven with HD, undergoing primary treatment with cytotoxic drugs were evaluated at three time-points: pre-therapy, mid-therapy and post-therapy. In contrast to the breast cancer patients, no significant changes in protein C, protein S and antithrombin III levels were observed in the NHL patients during the various stages of therapy. However in HD patients, the mean protein C values had a tendency to be higher at mid-therapy compared to pre-therapy and protein S levels had a tendency to be higher at mid-therapy compared to post-therapy. In lymphoma patients receiving primary cytotoxic treatment we did not find changes in anticoagulant parameters that can explain a chemotherapy-induced hypercoagulable state, as has been reported in breast cancer patients.
authors.affiliation: Division of Hematology, Rabin Medical Center, Tel-Aviv, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Bairey
authors.forename: U
authors.initials: U
authors.lastname: Gabbay
authors.forename: D
authors.initials: D
authors.lastname: Blickstein
authors.forename: P
authors.initials: P
authors.lastname: Stark
authors.forename: M
authors.initials: M
authors.lastname: Prokocimer
authors.forename: O
authors.initials: O
authors.lastname: Epstein
authors.forename: M
authors.initials: M
authors.lastname: Shaklai
authors.forename: J
authors.initials: J
authors.lastname: Lahav
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D000990:Antithrombin III / Q000032:analysis; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006689:Hodgkin Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects; D008223:Lymphoma / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage / Q000009:adverse effects; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage / Q000009:adverse effects; D010314:Partial Thromboplastin Time; D010958:Plasminogen / Q000032:analysis; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D011344:Procarbazine / Q000008:administration & dosage / Q000009:adverse effects; D011486:Protein C / Q000032:analysis*; D017293:Protein S / Q000032:analysis*; D019851:Thrombophilia / Q000139:chemically induced*; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects; D000979:alpha-2-Antiplasmin / Q000032:analysis
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D011486:Protein C; D017293:Protein S; D000979:alpha-2-Antiplasmin; D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014747:Vinblastine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D000990:Antithrombin III; D010958:Plasminogen; D008942:Mitoxantrone; D002955:Leucovorin; D011241:Prednisone; D008727:Methotrexate