Fibrinogen structure and fibrin clot assembly.
Fibrinogen is a complex multifunctional protein, which contains constitutive association sites (gammaXL, D:D, Da, Db) as well as cryptic sites that become exposed as a result of fibrinogen proteolysis by thrombin (EA, EB). Utilization of these sites by self-association (gammaXL or D:D) or by association with exposed complementary fibrin sites (Da:EA, Db:EB) produces an orderly process of molecular assembly to form linear and branched fibrils, concomitant with lateral fibril associations and factor XIIIa-mediated fibrin crosslinking that together result in the mature fibrin network.
Mosesson
M W
MW
University of Wisconsin Medical School, Sinai Samaritan Medical Center, Milwaukee 53233, USA.
D001665:Binding Sites; D001777:Blood Coagulation / Q000502:physiology*; D019281:Dimerization; D005337:Fibrin / Q000502:physiology*; D005340:Fibrinogen / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011108:Polymers; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D011503:Transglutaminases / Q000378:metabolism
D011108:Polymers; D005337:Fibrin; D005340:Fibrinogen; D011503:Transglutaminases