Penetration of ceftazidime into middle ear fluid in children with otitis media with effusion.
Twenty-five children with otitis media with effusion received ceftazidime 50 mg/kg intravenously before bilateral myringotomy with insertion of tympanostomy tubes. Concentrations of ceftazidime measured in serum and middle ear fluid exceeded 4 mg/L (i.e., largely above the minimal inhibitory concentrations for the gram-negative pathogens commonly recovered from children with otitis media) for at least 4 hours. Mean peak concentrations occurred 30 to 90 minutes after the injection and reached 11 to 14 mg/L. These results are in keeping with the clinical efficacy of ceftazidime in the treatment of chronic middle ear infections in children.
Bégué
P
P
Department of Pediatrics, Hôpital des Enfants A. Trousseau, Paris, France.
Garabédian
E N
EN
Bertrand
C
C
Aubert
B
B
Chiche
D
D
D002442:Ceftazidime / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002511:Cephalosporins / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005122:Exudates and Transudates / Q000737:chemistry; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010034:Otitis Media with Effusion / Q000188:drug therapy / Q000378:metabolism*
D002511:Cephalosporins; D002442:Ceftazidime