Activated protein C resistance, factor V Leiden, and central retinal vein occlusion in young adults.
OBJECTIVE
To confirm the relationship between resistance to activated protein C (APC), factor V Leiden, and central retinal vein occlusion in young adults as reported in a recent study of patients younger than 50 years.


METHODS
Patients younger than 50 years with central retinal vein occlusion were identified from the medical records of the Wills Eye Hospital Retina and Retina Vascular Services. Blood samples were taken from each patient and analyzed for resistance to APC and identification of factor V Leiden.


RESULTS
Only 1 (4.7%) of 21 patients evidenced resistance to APC and the presence of factor V Leiden. This patient was also the only one to report a family history of thrombotic disease.


CONCLUSIONS
We were unable to confirm the high percentage of resistance to ACP among young adult patients with central retinal vein occlusion. The finding of resistance to APC in only 1 (4.7%) of 21 patients is similar to that found in the general population.
Gottlieb
J L
JL
Retina Service of Wills Eye Hospital, Philadelphia, PA, USA. Gottlieb@eyesee.ophth.wisc.edu
Blice
J P
JP
Mestichelli
B
B
Konkle
B A
BA
Benson
W E
WE
D000328:Adult; D004247:DNA / Q000032:analysis; D004789:Enzyme Activation; D005165:Factor V / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011486:Protein C / Q000378:metabolism*; D012170:Retinal Vein Occlusion / Q000097:blood*
D011486:Protein C; C095381:factor V Leiden; D005165:Factor V; D004247:DNA