Cell wall active antifungal compounds produced by the marine fungus hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation.
The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-15G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized medium, titers of the lipodepsipeptide and the polylactones reached approximately 200-400 mg/liter and 25-50 mg/liter, respectively. The optimum fermentation temperature for production of 15G256 gamma was 28 degrees C. Seawater appeared to have an inhibitory effect on metabolite accumulation at lower fermentation temperatures.
Abbanat
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Natural Products Research, Wyeth-Ayerst Research, NY 10965, USA.
Leighton
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Maiese
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Jones
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Pearce
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Greenstein
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D000935:Antifungal Agents / Q000378:metabolism*; D002473:Cell Wall / Q000187:drug effects*; D005285:Fermentation; D013098:Xylariales / Q000145:classification* / Q000378:metabolism
D000935:Antifungal Agents