title: [A study on accuracy of rCBF measurements loaded with acetazolamide based on the microsphere model using iodine-123-IMP SPECT].
abstract: We studied the accuracy of the method for measuring regional cerebral blood flow (rCBF) loaded with acetazolamide based on the microsphere model using iodine-123-IMP (IMP) SPECT. Two methods were examined, the super-early microsphere method with continuous withdrawal of arterial blood using the SPECT image obtained 5 min after tracer injection and the early microsphere method with one-point arterial sampling using the SPECT image obtained 30 min postinjection. On five subjects, after acetazolamide administration we measured rCBF by the analysis based on the two-compartment model using the data derived from dynamic SPECT scans and the sequential arterial blood sampling after IMP injection. Values of rCBF obtained by both super-early microsphere method and early microsphere method were significantly correlated with those obtained by the two-compartment model analysis (r = 0.982, 0.930, respectively). We conclude that it is possible to use the method based on the microsphere model in measuring rCBF loaded with acetazolamide. The early microsphere method with one-point sampling should be used clinically because of its simplicity and less-invasiveness.
authors.affiliation: Department of Radiological Technology, College of Biomedical Technology, Niigata University.
authors.forename: M
authors.initials: M
authors.lastname: Ohkubo
authors.forename: I
authors.initials: I
authors.lastname: Odano
authors.forename: E
authors.initials: E
authors.lastname: Noguchi
authors.forename: H
authors.initials: H
authors.lastname: Ohtaki
authors.forename: M
authors.initials: M
authors.lastname: Shibaki
authors.forename: Y
authors.initials: Y
authors.lastname: Dobashi
authors.forename: T
authors.initials: T
authors.lastname: Yokoi
mesh_terms: D000086:Acetazolamide; D000328:Adult; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D017241:MELAS Syndrome / Q000000981:diagnostic imaging; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D008954:Models, Biological; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D020367:Iofetamine; D000086:Acetazolamide