[Alkyl nitrosoureidodioxans and alkyl nitrosoureidopropane diols -- new groups of antitumor compounds].
1,3-dioxan- and 1,3-propane diol derivatives of alkyl nitrosourea have been synthesized and studied. Like other 2/chloroethylnitrosoureas, they exerted pronounced influence on a wide range of transplantable tumors, including those transplanted intracranially. Antitumor effect was found to depend on C5 and C2 atom substituent in the 1,3-dioxan cycle and 1,3-propane diol, respectively. The therapeutic effect and toxicity of 1,3-propane diol derivatives were higher than those of 1,3-dioxan. The substances lost all antitumor properties if a methyl group was substituted for the 2-chloroethyl one, even though a nitroso group was retained in their structure.
Kon'kov
S A
SA
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Stukov
A N
AN
Reztsova
V V
VV
Krylova
I M
IM
Ivin
B A
BA
VA Filov
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004146:Dioxanes / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D011409:Propylene Glycols / Q000494:pharmacology*; D051381:Rats; D016019:Survival Analysis
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D004146:Dioxanes; D009607:Nitrosourea Compounds; D011409:Propylene Glycols
Alkilnitrozoureidodioksany i alkilnitrozoureidopropandioly -- novye gruppy protivoopukholevykh soedineniĭ.