title: [NF-kappa B and inflammatory intestinal diseases].
abstract: The chronic inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC), are multifactorial pathologies. There is overwhelming evidence that genetic factors play a pivotal role in the predisposition to suffer from IBD. The severity of the inflammatory response depends on genes coding for proteins which regulate the cytokine production. Among them, NF kappa B stands out as the most important regulator of the gene expression of several pro- and anti-inflammatory genes. We present hereby its structure, function, regulation and the role played in IBD. Different theories relating the mechanism of action of glucocorticosteroids to NF kappa B are described in this review as well. The more accurate knowledge of the NF kappa B physiology has allowed new therapeutical approaches to inflammatory diseases to appear, namely the transfer to primary intestinal epithelial cells by an adenoviral vector of a mutant I kappa B (the inhibitory protein of NF kappa B) and the local use of p65 antisense phosphorothioate oligonucleotides.
authors.affiliation: Departamento de Gastroenterología, Universidad Libre de Amsterdam, Países Bajos.
authors.forename: M P
authors.initials: MP
authors.lastname: Nosti-Escanilla
authors.forename: A S
authors.initials: AS
authors.lastname: Peña
mesh_terms: D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D016328:NF-kappa B / Q000235:genetics*
chemical_list: D016328:NF-kappa B
vernacular_title: NF kappa B y enfermedad inflamatoria intestinal.