Protection against apoptosis by monoamine oxidase A inhibitors.
Several lines of evidence have been accumulating indicating that an important role may be played by mitochondrial homeostasis in the initiation phase, the first stage of apoptosis. This work describes the results obtained by using different inhibitors of monoamine oxidases (MAO), i.e. pargyline, clorgyline and deprenyl, on mitochondrial integrity and apoptosis. Both pargyline and clorgyline are capable of protecting cells from apoptosis induced by serum starvation while deprenyl is ineffective. These data represent the first demonstration that MAO-A inhibitors may protect cells from apoptosis through a mechanism involving the maintenance of mitochondrial homeostasis.
Malorni
W
W
Department of Ultrastructures, Istituto Superiore di Sanità, Rome, Italy. Malorni@mclink.it
Giammarioli
A M
AM
Matarrese
P
P
Pietrangeli
P
P
Agostinelli
E
E
Ciaccio
A
A
Grassilli
E
E
Mondovi
B
B
D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D008996:Monoamine Oxidase Inhibitors