Synthetic analogues of netropsin and distamycin. IV. Synthesis of a new carbocyclic analogue of distamycin with alkylating side groups.
A carbocyclic analogue of distamycin was obtained, in which the N-methylpyrrole rings were substituted by disubstituted benzene rings. Additionally, N-chloro- or N-bromoacetyl groups, displaying alkylating properties, were introduced. The synthesis, starting from 3,5-dinitrobenzoyl chloride, consisted of five stages.
Markowska
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A
Department of Organic Chemistry, Institute of Chemistry, Medical Academy of Białystok.
Bartulewicz
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D
Pućkowska
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Rózański
A
A
D000477:Alkylating Agents / Q000737:chemistry; D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D001554:Benzene / Q000737:chemistry; D004214:Distamycins / Q000138:chemical synthesis*; D009429:Netropsin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009579:Nitrobenzoates / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry
D000477:Alkylating Agents; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D004214:Distamycins; D009579:Nitrobenzoates; D011758:Pyrroles; C112321:chloroacetyldistamycin; C013964:3,5-dinitrobenzoyl chloride; D009429:Netropsin; C030000:stallimycin; C048820:M-bromoacetyldistamycin; D001554:Benzene; C096654:N-methylpyrrole