Intestinal absorption and enterohepatic circulation of folic acid: effect of ethanol.
This study sought to determine the intestinal in vivo absorption of folic acid by the whole intestine, and the appearance of this compound in bile in control and ethanol-fed rats. Intestinal folic acid absorption in rats with the bile duct cannulated decreased in ethanol-fed rats with respect to control rats. This difference was significant at 1 and 2.5 microM concentrations of folic acid. This result is in contrast with previous work in our laboratory on rats with intact bile ducts, where ethanol-fed rats had an increase in folic acid absorption. The results obtained in the present work suggest an impaired enterohepatic recycling of folic acid in ethanol-fed rats.
Fernández
O
O
Departamento de Fisiología y Biología Animal, Facultad de Farmacia, Universidad de Sevilla, España.
Carreras
O
O
Murillo
M L
ML
D000821:Animal Feed; D000818:Animals; D001646:Bile / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D002492:Central Nervous System Depressants / Q000008:administration & dosage; D004764:Enterohepatic Circulation / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage; D005492:Folic Acid / Q000187:drug effects / Q000378:metabolism / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D002492:Central Nervous System Depressants; D000431:Ethanol; D005492:Folic Acid