title: An overview of progress in antisense therapeutics.
authors.affiliation: Isis Pharmaceuticals, Inc., Carlsbad, CA 92008, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Crooke
mesh_terms: D000818:Animals; D001682:Biological Availability; D004333:Drug Administration Routes; D005544:Forecasting; D005786:Gene Expression Regulation / Q000187:drug effects; D015316:Genetic Therapy; D006207:Half-Life; D000882:Haplorhini; D006801:Humans; D007928:Lethal Dose 50; D016376:Oligonucleotides, Antisense / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D012377:Rodentia; D013045:Species Specificity; D013873:Thionucleotides / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D016376:Oligonucleotides, Antisense; D013873:Thionucleotides