title: Autosomal recessive cornea plana. A clinical and genetic study of 78 cases in Finland.
abstract: OBJECTIVE
  To review the literature of autosomal recessive cornea plana (RCP) and to perform a clinical and genetic study on this disorder in Finland. The 78 Finnish RCP patients represent the majority of RCP cases worldwide; outside Finland only 35 cases have been reported.
  
  
  METHODS
  Families with RCP, particularly in northern Finland, have been followed up by the senior author since the 1950s and extensive genealogical studies have been made.
  
  
  RESULTS
  The most typical symptoms are greatly reduced corneal refraction, 25-35 dioptres, causing strong hyperopia, slight microcornea, an extended limbus zone, a central, deep corneal opacity and a marked arcus senilis, seen even before the age of 20. We present a pedigree comprising 33 affected persons with cornea plana. We have mapped the two genes for the dominantly and the recessively inherited type of cornea plana to the same region on the long arm of chromosome 12, (12q21).
  
  
  CONCLUSIONS
  In northern Finland RCP has a higher frequency than elsewhere, probably as a result of a strong founder effect in the population that arrived in these regions approx. 400 years ago. The strong accumulation of this rare disease in these isolated areas and the strong genealogical connections between different families with RCP, suggest that probably all the Finnish RCP cases are caused by the same mutation.
authors.affiliation: The Folkhälsan Institute of Genetics, Helsinki, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Forsius
authors.forename: M
authors.initials: M
authors.lastname: Damsten
authors.forename: A W
authors.initials: AW
authors.lastname: Eriksson
authors.forename: J
authors.initials: J
authors.lastname: Fellman
authors.forename: S
authors.initials: S
authors.lastname: Lindh
authors.forename: E
authors.initials: E
authors.lastname: Tahvanainen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D003315:Cornea / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005387:Finland; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014792:Visual Acuity / Q000502:physiology