title: Laboratory assessment of the molluscicidal and cercaricidal activities of the Egyptian weed, Solanum nigrum L.
abstract: The molluscicidal properties of Solanum nigrum L. were tested against three Egyptian snail species (Biomphalaria alexandrina, Bulinus truncatus and Lymnaea natalensis), each an intermediate host of parasites causing human schistosomiasis or fascioliasis. The plant was collected in two regions within Egypt: Fayium and Giza. Snails were exposed for 24 and 48 h, to the dry powdered fruits and leaves or to crude water extracts of the powders, and mortality was recorded. The water extract of the leaves collected in Fayium (FLWE) had the highest molluscicidal activity, with median lethal concentrations (LC50) of 18.6 mg/litre for Bi. alexandrina, 14.5 mg/litre for Bu. truncatus and 17.7 mg/litre for L. natalensis. When Bi. alexandrina infected with Schistosoma mansoni were exposed to FLWE (20 or 25 mg/litre), they shed significantly fewer cercariae than unexposed snails (P < 0.02). The cercaricidal properties of FLWE were directly tested against S. haematobium, S. mansoni and Fasciola gigantica cercariae and a time-concentration relationship was observed; the concentrations needed to kill all cercariae (LC100) within 30 min of exposure were 30 mg/litre for both S. haematobium and S. mansoni and 40 mg/litre for F. gigantica.
authors.affiliation: Institute of Research for Tropical Medicine, General Organization for Teaching Hospitals and Institutes, Cairo, Egypt.
authors.forename: A H
authors.initials: AH
authors.lastname: Ahmed
authors.forename: R M
authors.initials: RM
authors.lastname: Ramzy
mesh_terms: D000818:Animals; D004199:Disease Vectors; D004356:Drug Storage; D005209:Fasciola / Q000187:drug effects; D006801:Humans; D007306:Insecticides / Q000494:pharmacology; D010572:Pest Control, Biological / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology; D010947:Plants, Toxic; D012548:Schistosoma haematobium / Q000187:drug effects; D012550:Schistosoma mansoni / Q000187:drug effects / Q000502:physiology*; D012552:Schistosomiasis / Q000517:prevention & control / Q000635:transmission; D012908:Snails / Q000187:drug effects / Q000469:parasitology*
chemical_list: D007306:Insecticides; D010936:Plant Extracts