Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders.
We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH*2 allele (chi 2 = 8.30, d.f. = 1; P = 0.004) and lack of the TH*1 allele (chi 2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.
Serretti
A
A
Istituto Scientifico H San Raffaele, Department of Neuroscience, University of Milano School of Medicine, Italy.
Macciardi
F
F
Cusin
C
C
Verga
M
M
Pedrini
S
S
Smeraldi
E
E
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004252:DNA Mutational Analysis; D003866:Depressive Disorder / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D009419:Nerve Tissue Proteins; D004247:DNA; D014446:Tyrosine 3-Monooxygenase