[Management of hyposalivation caused by oxybutynin chloride in the treatment of the unstable bladder].
OBJECTIVE
To know the incidence of adverse reactions from Oxybutynin Chloride, with special reference to salivary hyposecretion and to evaluate the effectiveness of the different alternatives employed to solve it.


METHODS
144 adult patients with signs and symptoms of voiding urgency and detrusor-hyperactivity incontinence, who were treated with Oxybutynin 5 to 15 mg/day. Hyposecretion of several exocrine glands was evaluated using a questionnaire that included subjective and objective parameters. For managing purposes, patients were divided into 3 groups: 1) General measures; 2) Therapy with sialagogues; and 3) Replacement therapy with artificial saliva.


RESULTS
42% patients treated with Oxybutynin developed mild-to-moderate hyposialism. 26% had severe hyposialism, always related to high dose Oxybutynin. 6% skin dryness, 3% eye dryness and 2% dryness in all the above glands (dry syndrome). Regarding treatment, most patients with mild-to-moderate hyposialism were managed with simple general measures. In severe hyposialism, both sialagogues (Eledoisine) and artificial saliva (Bucalsone) were resolutive in over 90% cases.


CONCLUSIONS
Oxybutynin is an effective drug to stop detrusor hyperactivity, but it has a high rate of anticholinergic adverse reactions. There is a number of effective therapeutic options available to alleviate these effects, which allow the patient to continue with the treatment.
Arango Toro
O
O
Servicio y Cátedra de Urología, Hospital del Mar, Universidad Autónoma de Barcelona.
Nohales Taurines
G
G
Cortadellas Angel
R
R
Castro Santamaría
R
R
Gelabert Mas
A
A
D000328:Adult; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000009:adverse effects*; D014549:Urinary Incontinence / Q000188:drug therapy*; D014987:Xerostomia / Q000139:chemically induced*
D018680:Cholinergic Antagonists; D008333:Mandelic Acids; C005419:oxybutynin
Manejo de la hiposialia producida por el cloruro de oxibutinina en el tratamiento de la vejiga inestable.