title: Treatment of T prolymphocytic leukemia with allogeneic bone marrow transplantation.
abstract: T prolymphocytic leukemia (T-PLL) is an unusual disease characterized by high white cell counts, older age at presentation, splenomegaly and a very aggressive clinical course. We describe a 47-year-old male with refractory T-PLL who was treated with high-dose chemoradiotherapy and allogeneic bone marrow transplantation (BMT) from an HLA-matched sibling. The transplant was complicated by both acute and chronic graft-versus-host disease (GVHD). The patient achieved complete remission and remains in remission 3 years after the transplant.
authors.affiliation: Bone Marrow Transplantation, Baylor University Medical Center/Texas Oncology, Dallas 75246, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Collins
authors.forename: L A
authors.initials: LA
authors.lastname: Piñeiro
authors.forename: E D
authors.initials: ED
authors.lastname: Agura
authors.forename: J W
authors.initials: JW
authors.lastname: Fay
mesh_terms: D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease; D006650:Histocompatibility Testing; D006801:Humans; D015463:Leukemia, Prolymphocytic / Q000628:therapy*; D015458:Leukemia, T-Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged