Parallel-stranded duplexes and quartet assemblies formed by oligonucleotides containing isoguanine.
Oligonucleotides with isoguanine-cytosine base pairs form duplexes with parallel chain orientation. This strong base pair dictates the strand polarity when additional dA-dT or N7Ad-dT pairs are present. The same is observed for the isocytosine-guanine pair. Quartet structures are built by the self-assembly of oligonucleotides containing short runs of isoguanine or 7-deazaisoguanine. New base pairs between isoguanine or guanine and 5-aza-7-deazaguanine are presented.
Seela
F
F
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
Wei
C
C
Melenewski
A
A
Leonard
P
P
D001482:Base Composition; D003596:Cytosine / Q000031:analogs & derivatives; D004355:Drug Stability; D006147:Guanine; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D011743:Pyrimidines; D011758:Pyrroles
C113087:7-deazaisoguanine; D009838:Oligodeoxyribonucleotides; D011743:Pyrimidines; D011758:Pyrroles; C093270:isocytosine; D006147:Guanine; D003596:Cytosine; C008183:isoguanine