title: Controlled local delivery of antimicrobials in the treatment of periodontitis.
abstract: Five local delivery systems with five different antimicrobial agents have been discussed. All are capable of delivering high concentrations of their antimicrobial to the site of the periodontal infection. Although only one system, tetracycline fiber, is available in United States, two other systems, chlorhexidine chip and doxycycline polymer, may be available in the near future. Two other systems, metronidazole gel and minocycline ointment, are available in other countries. Data from pertinent studies were presented as were techniques for using the various systems. Indications for the use of the products were also discussed. In selecting the appropriate delivery system, the clinician has to weigh the efficacy of the products, ease of use, availability, and cost. Although local delivery systems do not replace existing periodontal therapies, they do have a place in the treatment of periodontitis and offer the dentist additional methods to aid in the control of periodontal diseases.
authors.affiliation: Department of Periodontics, University of Missouri-Kansas City, School of Dentistry, Missouri, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Killoy
authors.forename: A M
authors.initials: AM
authors.lastname: Polson
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D002710:Chlorhexidine / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage; D016527:Drug Costs; D016503:Drug Delivery Systems; D005060:Europe; D005782:Gels; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D008911:Minocycline / Q000008:administration & dosage; D009824:Ointments; D010518:Periodontitis / Q000188:drug therapy*; D014677:Pharmaceutical Vehicles; D011145:Polyvinyls; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D005782:Gels; D009824:Ointments; D014677:Pharmaceutical Vehicles; D011145:Polyvinyls; D008795:Metronidazole; C016438:ethylenevinylacetate copolymer; D008911:Minocycline; D004318:Doxycycline; D002710:Chlorhexidine