[The effect of pyrimidine derivatives on the sulfhydryl status of immunocompetent cells in vivo: the interrelationship with Ca2(+)-ATPase and antimutagenic activity].
It was demonstrated in experiments on guinea pigs that a 30 mg/kg dose of ximedon changes the content of SH-groups in immunocompetent cells depending on the duration of drug administration and the organ to which the cells under test belong. Maximum increase of the SH-groups was recorded in the thymocytes. The dynamics of changes in Ca(2+)-ATPase activity repeated the fluctuations in the SH-group content in the splenic and bone marrow cells. In the bone marrow cells of CBA x C57B1 mice 3 mg/kg ximedon suppressed the induction of chromosome aberrations caused by cyclophosphane. The interrelationship of changes in the cell sulfhydryl status with Ca(2+)-ATPase activity and the antimutagenic effect of ximedon is discussed.
Slabnov
Iu D
IuD
Research Department, Republican Medical Diagnostic Center Kazan', Russia.
Cherepnev
G V
GV
Tsibul'kin
A P
AP
Karimova
F G
FG
Garaev
R S
RS
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000187:drug effects* / Q000378:metabolism; D002869:Chromosome Aberrations; D006168:Guinea Pigs; D007121:Immunocompetence / Q000187:drug effects*; D008198:Lymph Nodes / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011743:Pyrimidines / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
D016587:Antimutagenic Agents; D011743:Pyrimidines; D013438:Sulfhydryl Compounds; C069705:xymedon; D000252:Calcium-Transporting ATPases
Vliianie pirimidinovykh proizvodnykh na sul'gidril'nyĭ status immunokompetentnykh kletok in vivo: vzaimosviaz' s Ca2(+)-ATFaznoĭ i antimutagennoĭ aktivnost'iu.