title: The effect of trimeric 2',5'-oligoadenylic acid and its epoxy-derivative on human immunodeficiency virus (HIV-1) reproduction and retroviruses reverse transcriptase activity.
abstract: The effect of trimeric 2',5'-oligoadenylic acid (2',5' A3) and its epoxy-derivative (2',5'-A2 (RAA) on human immunodeficiency virus (HIV-1) reproduction was studied. An HIV-1 infectivity titer decrease was shown on the model of limphoblastoid cells when the substances under study were used. The interferonogenic effect of both substances was discovered. 2',5'-A2 (RAA) inhibited the activity of retrovirus reverse transcriptase (a C-type).
authors.affiliation: Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kiev.
authors.lastname: Tkachuk ZYu
authors.forename: S L
authors.initials: SL
authors.lastname: Rybalko
authors.forename: L I
authors.initials: LI
authors.lastname: Semernikova
authors.forename: V V
authors.initials: VV
authors.lastname: Tkachuk
authors.forename: M P
authors.initials: MP
authors.lastname: Zavelevich
authors.forename: L V
authors.initials: LV
authors.lastname: Tkachuk
authors.forename: T
authors.initials: T
authors.lastname: Eremenko
authors.forename: I A
authors.initials: IA
authors.lastname: Mikhailopulo
authors.forename: G K
authors.initials: GK
authors.lastname: Matsuka
mesh_terms: D000227:Adenine Nucleotides / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004794:Enzyme Repression; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D006801:Humans; D009843:Oligoribonucleotides / Q000494:pharmacology*; D012194:RNA-Directed DNA Polymerase / Q000187:drug effects*; D014407:Tumor Cells, Cultured; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000227:Adenine Nucleotides; D000998:Antiviral Agents; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D012194:RNA-Directed DNA Polymerase