Transcriptional control during T-cell development.
During the past few years, the essential role of distinct transcription factors in specifying cell-fate decisions in a stepwise fashion during T-cell differentiation has been revealed. One striking feature is that a single factor can act at several sites throughout T-cell development, possibly through interactions with different partners. The challenge is now to understand how these interactions can account for the co-ordination of complex extracellular signals and gene expression programs, such as those involved in T-cell receptor gene recombination and expression.
Clevers
H
H
Department of Immunology, University Hospital, Utrecht, The Netherlands. h.clevers@lab.azu.nl
Ferrier
P
P
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D005809:Genes, Regulator / Q000235:genetics*; D006801:Humans; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology*