Evaluation of endozepine-like immunoreactivity in the frontal cortex of suicide victims.
Diazepam-binding inhibitor (DBI) and its processing products, including the octadecaneuropeptide (ODN), are polypeptides called endozepines which have multiple biological effects, including regulation of mitochondrial steroidogenesis and modulation of GABA-gated chloride channels. Concentrations of ODN-like immunoreactivity (ODN-Li) were measured by radioimmunoassay in the frontal cortex of nine drug-free suicides and nine drug-free sudden-death victims. The level of ODN-Li was higher in the right than in the left frontal cortex, in both suicide (p < 0.05) and control (p < 0.02) subjects. No significant differences were found between suicides and controls either in the right and left cortex, or when considering the gender and the post-mortem diagnosis of depression.
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Service Hospitalo-universitaire de Psychiatrie de l'Enfant et de l'Adolescent (69 I 02), CHS le Vinatier, BRON, France.
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Kopp
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Vaudry
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Miachon
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D000328:Adult; D002352:Carrier Proteins / Q000032:analysis*; D016022:Case-Control Studies; D026261:Diazepam Binding Inhibitor; D005069:Evaluation Studies as Topic; D005260:Female; D005625:Frontal Lobe / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000032:analysis*; D010446:Peptide Fragments; D011863:Radioimmunoassay; D018709:Statistics, Nonparametric; D013256:Steroids / Q000096:biosynthesis; D013405:Suicide
D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor; D009479:Neuropeptides; D010446:Peptide Fragments; D013256:Steroids; C067529:diazepam binding inhibitor (33-50)