title: Ionized and total magnesium concentrations in blood from dogs with naturally acquired parvoviral enteritis.
abstract: OBJECTIVE
  To determine whether pretreatment total and ionized blood magnesium concentrations were associated with outcome for dogs with parvoviral enteritis and whether ionized magnesium concentration was related to total magnesium concentration or other laboratory values.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  61 healthy dogs and 72 dogs with parvoviral enteritis.
  
  
  METHODS
  Total, ionized, and pH-normalized ionized magnesium concentrations, ionized and pH-normalized ionized calcium concentrations, pH, sodium and potassium concentrations, and Hct were measured prior to treatment. chi 2 Analyses were used to test for associations between outcome and age and between outcome and treatment with antiendotoxin antibody. Pearson's correlation coefficients were calculated to determine whether ionized magnesium concentration was linearly associated with other laboratory values.
  
  
  RESULTS
  Total and ionized magnesium concentrations were not significantly different between healthy dogs and dogs with parvoviral enteritis or between dogs surviving and those not surviving parvoviral enteritis. The only laboratory value strongly correlated with ionized magnesium concentration was pH-normalized ionized magnesium concentration. Of the factors tested, none were significantly associated with outcome, except that dogs 16 weeks old or less treated with antiendotoxin antibody were significantly more likely to die than were dogs 16 weeks old or less that were not treated with antiendotoxin antibody.
  
  
  CONCLUSIONS
  Total and ionized blood magnesium concentrations cannot be used to consistently predict outcome for dogs with parvoviral enteritis. Antiendotoxin antibody should be used with caution in dogs 16 weeks old or less.
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
authors.forename: F A
authors.initials: FA
authors.lastname: Mann
authors.forename: G D
authors.initials: GD
authors.lastname: Boon
authors.forename: C C
authors.initials: CC
authors.lastname: Wagner-Mann
authors.forename: D S
authors.initials: DS
authors.lastname: Ruben
authors.forename: D P
authors.initials: DP
authors.lastname: Harrington
mesh_terms: D000367:Age Factors; D000818:Animals; D015331:Cohort Studies; D004283:Dog Diseases / Q000097:blood* / Q000628:therapy; D004285:Dogs; D004751:Enteritis / Q000097:blood / Q000662:veterinary*; D006863:Hydrogen-Ion Concentration; D007116:Immunization, Passive; D007136:Immunoglobulins; D008274:Magnesium / Q000097:blood*; D010322:Parvoviridae Infections / Q000097:blood / Q000628:therapy / Q000662:veterinary*; D017993:Parvovirus, Canine; D011379:Prognosis; D011446:Prospective Studies; D012016:Reference Values
chemical_list: D007136:Immunoglobulins; C042866:antilipopolysaccharide antibodies; D008274:Magnesium