Synthesis and in vitro anthelmintic activity against Nippostrongylus brasiliensis of new 2-amino-4-hydroxy-delta-valerolactam derivatives.
The synthesis of a series of 2-amino-4-hydroxy-delta-valerolactam derivatives is described (compounds 4 to 10). These compounds showed a high anthelmintic in vitro activity against the Nippostrongylus brasiliensis model.
Gordon
S
S
Cátedra de Química Farmacéutica, Fac. de Química, Universidad de la República, Montevideo, Uruguay.
Costa
L
L
Incerti
M
M
Manta
E
E
Saldaña
J
J
Domínguez
L
L
Mariezcurrena
R
R
Suescun
L
L
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D008297:Male; D008968:Molecular Conformation; D009559:Nippostrongylus / Q000187:drug effects* / Q000254:growth & development; D010881:Piperidones / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017206:Strongylida Infections / Q000188:drug therapy / Q000469:parasitology*; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D010881:Piperidones; C043384:2-piperidone