title: Cardiovascular alterations caused by the administration of 2% mepivacaine HCl with 1:20,000 levonordefrin (Carbocain) in dogs.
abstract: We studied possible cardiovascular effects (systolic, diastolic, mean arterial blood pressures, and heart rate) caused by intraoral infiltrative administration of 2% mepivacaine HCl with 1:20,000 levonordefrin in dogs (Canis familiaris), using a Beckman electrophysiograph. Doses used were 0.514 and 1.542 mg/kg body weight corresponding to one and three 1.8-ml cartridges, respectively, in 70-kg average weight adult men. A statistically significant increase was observed in the systolic and the mean arterial blood pressures.
authors.affiliation: Departamento de Stomatologia, Faculdade de Odontologia, Universidade de São Paulo, Brasil.
authors.forename: J L
authors.initials: JL
authors.lastname: Simone
authors.forename: N
authors.initials: N
authors.lastname: Tortamano
authors.forename: P L
authors.initials: PL
authors.lastname: Armonia
authors.forename: R G
authors.initials: RG
authors.lastname: Rocha
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008619:Mepivacaine / Q000494:pharmacology*; D008771:Nordefrin / Q000494:pharmacology*; D013599:Systole / Q000187:drug effects; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D014662:Vasoconstrictor Agents; D008619:Mepivacaine; D008771:Nordefrin