The allopurinol hypersensitivity syndrome.
We describe a 61-year-old male patient who was treated with allopurinol and developed fever, a skin rash, eosinophilia and severe renal and liver dysfunction. We discuss the allopurinol hypersensitivity syndrome as a serious complication of the use of allopurinol, and briefly review the aetiology, prevention and treatment modalities.
Pluim
H J
HJ
Interne Geneeskunde, Canisius Wilhelmina Ziekenhuis, Nijmegen, Netherlands.
van Deuren
M
M
Wetzels
J F
JF
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D000493:Allopurinol / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D006073:Gout / Q000188:drug therapy; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome
D000893:Anti-Inflammatory Agents; D006074:Gout Suppressants; D000493:Allopurinol; D011241:Prednisone