Thiopurine treatment in childhood leukemia. Metabolic aspects and sensitivity.
De Abreu
R A
RA
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
Bokkerink
J P
JP
Keuzenkamp-Jansen
C W
CW
Stet
E H
EH
Trijbels
J F
JF
D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000378:metabolism; D015122:Mercaptopurine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008727:Methotrexate / Q000008:administration & dosage; D008780:Methyltransferases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D013866:Thioguanine / Q000493:pharmacokinetics / Q000627:therapeutic use*
D000964:Antimetabolites, Antineoplastic; D015122:Mercaptopurine; D008780:Methyltransferases; C022745:thiopurine methyltransferase; D013866:Thioguanine; D008727:Methotrexate