Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
Cherney
R J
RJ
Chemical and Physical Sciences and Inflammatory Diseases Research, The DuPont Merck Pharmaceutical Co., Experimental Station, Wilmington Delaware 19880-0500, USA.
Wang
L
L
Meyer
D T
DT
Xue
C B
CB
Wasserman
Z R
ZR
Hardman
K D
KD
Welch
P K
PK
Covington
M B
MB
Copeland
R A
RA
Arner
E C
EC
DeGrado
W F
WF
Decicco
C P
CP
D015195:Drug Design; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020784:Matrix Metalloproteinase 8; D061965:Matrix Metalloproteinase Inhibitors; D008958:Models, Molecular; D015394:Molecular Structure; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007769:Lactams; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D020784:Matrix Metalloproteinase 8