title: N4-hydroxy-5-halogeno-2'-deoxycytidine S and their 5'-mono-phosphates as inhibitors of thymidylate synthase and in vitro antileukemic agents.
authors.affiliation: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Felczak
authors.forename: M
authors.initials: M
authors.lastname: Bretner
authors.forename: J M
authors.initials: JM
authors.lastname: Dzik
authors.forename: B
authors.initials: B
authors.lastname: Gołos
authors.forename: Z
authors.initials: Z
authors.lastname: Zieliński
authors.forename: W
authors.initials: W
authors.lastname: Rode
authors.forename: T
authors.initials: T
authors.lastname: Kulikowski
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000633:toxicity; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000633:toxicity; D005467:Floxuridine / Q000493:pharmacokinetics / Q000633:toxicity; D007700:Kinetics; D007940:Leukemia L5178; D051379:Mice; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D005467:Floxuridine; D003841:Deoxycytidine; D013940:Thymidylate Synthase