title: Mink 5S rRNA genes map to 2q in three loci suggesting conservation of synteny with human 1q.
abstract: By in situ hybridization we show that the SS rRNA genes in the mink map to chromosome 2q in three loci. The 2q1.1 locus containing 34% of the 5S rDNA, maps close to the centromere, and the remaining two loci of the 5S rDNA map to 2q1.3 (52%) and to 2q2.3. (14%). These data were obtained with a tritiated transcript of the 5S rRNA gene containing 121 bp. In a comparative FISH study performed with a biotinylated transcript of the 5S rRNA gene the procedure failed to detect the 2q2.3 site. A closely corresponding difference between the two procedures experienced previously in man and in the crab-eating macaque is discussed. The present results suggest a homology between 2q in the mink and part of 1q in man harbouring the 5S rRNA genes in 1q42.13 and 1q31, respectively.
authors.affiliation: Department of Animal Science and Animal Health, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Christensen
authors.forename: B
authors.initials: B
authors.lastname: Lomholt
authors.forename: C
authors.initials: C
authors.lastname: Hallenberg
authors.forename: K V
authors.initials: KV
authors.lastname: Nielsen
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008907:Mink / Q000235:genetics*; D012341:RNA, Ribosomal, 5S / Q000235:genetics*
chemical_list: D012341:RNA, Ribosomal, 5S