Korormicin, a novel antibiotic specifically active against marine gram-negative bacteria, produced by a marine bacterium.
A novel antibiotic named korormicin was isolated from the marine bacterium, Pseudoalteromonas sp. F-420. This strain was isolated from the surface of a macro alga Halimeda sp. collected from Palau (the Republic of Belau). The planar structure of korormicin was determined by the result of 2D NMR studies and mass spectral data. Korormicin had specific inhibitory activity against marine Gram-negative bacteria, but was inactive against terrestrial microorganisms.
Yoshikawa
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K
Shimizu Laboratories, Marine Biotechnology Institute Co. Ltd., Shizuoka, Japan.
Takadera
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T
Adachi
K
K
Nishijima
M
M
Sano
H
H
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006088:Gram-Negative Aerobic Bacteria / Q000737:chemistry* / Q000145:classification; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D005231:Fatty Acids, Unsaturated; D007783:Lactones; C111296:korormicin