title: Penetration of ceftazidime into middle ear fluid in children with otitis media with effusion.
abstract: Twenty-five children with otitis media with effusion received ceftazidime 50 mg/kg intravenously before bilateral myringotomy with insertion of tympanostomy tubes. Concentrations of ceftazidime measured in serum and middle ear fluid exceeded 4 mg/L (i.e., largely above the minimal inhibitory concentrations for the gram-negative pathogens commonly recovered from children with otitis media) for at least 4 hours. Mean peak concentrations occurred 30 to 90 minutes after the injection and reached 11 to 14 mg/L. These results are in keeping with the clinical efficacy of ceftazidime in the treatment of chronic middle ear infections in children.
authors.affiliation: Department of Pediatrics, Hôpital des Enfants A. Trousseau, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Bégué
authors.forename: E N
authors.initials: EN
authors.lastname: Garabédian
authors.forename: C
authors.initials: C
authors.lastname: Bertrand
authors.forename: B
authors.initials: B
authors.lastname: Aubert
authors.forename: D
authors.initials: D
authors.lastname: Chiche
mesh_terms: D002442:Ceftazidime / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002511:Cephalosporins / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005122:Exudates and Transudates / Q000737:chemistry; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010034:Otitis Media with Effusion / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D002511:Cephalosporins; D002442:Ceftazidime