title: Treatment of patients with toxic multinodular goiter.
abstract: The medical records of 253 patients evaluated for toxic multinodular goiter from 1975 through 1993 were reviewed to determine treatment trends, success, and complications. Of the 235 (93%) treated, 174 (74%) received surgical treatment and 61 (26%) received radioiodine (131I) treatment. Three months after initial treatment, 82% of surgically treated patients became euthyroid or hypothyroid compared with 21% of the 131I group. Among the 131I-treated patients, 20% required a second treatment, whereas none needed further treatment in the surgical group. At 2 years, the estimated probability of success was similar. The probability of post-treatment hypothyroidism was significantly higher for surgically treated patients, which is expected.
authors.affiliation: Division of Endocrinology, Metabolism, Nutrition and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: D
authors.initials: D
authors.lastname: Erickson
authors.forename: H
authors.initials: H
authors.lastname: Gharib
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: J A
authors.initials: JA
authors.lastname: van Heerden
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006044:Goiter, Nodular / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D012008:Recurrence; D013961:Thyroid Gland / Q000473:pathology; D013965:Thyroidectomy / Q000009:adverse effects; D013971:Thyrotoxicosis / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
chemical_list: D007457:Iodine Radioisotopes