Antiviral effect of trimeric 2',5'-oligoadenylic acid and some of its analogues.
The antiviral effect of 2',5'-trioligoadenylate (2',5'-A3) and some of its analogues was studied using several model cell culture systems and viruses: mice L929 fibroblast cells inoculated with vaccine virus, testicular piglet cells inoculated with Aueszki disease virus (strain BUK-628), and the same culture inoculated with a reference strain of transmissible gastroenteritis virus, strain Purdue-115. Our results suggest that both 2',5'-trioligoadenylate and its analogues are promising antiviral substances against DNA- and RNA-containing viruses.
Tkachuk ZYu
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev.
Semernikova
L I
LI
Tkachuk
V V
VV
Reshot'ko
L M
LM
Tkachuk
L V
LV
Eremenko
T
T
Matsuka
G K
GK
Mikhailopulo
I A
IA
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured / Q000821:virology; D005347:Fibroblasts / Q000821:virology; D011558:Herpesvirus 1, Suid / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D009843:Oligoribonucleotides / Q000494:pharmacology*; D013552:Swine / Q000821:virology; D005760:Transmissible gastroenteritis virus / Q000187:drug effects*; D014616:Vaccinia virus / Q000187:drug effects*
D000227:Adenine Nucleotides; D000998:Antiviral Agents; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate