title: Effects of compounds extracted from Tanacetum microphyllum on arachidonic acid metabolism in cellular systems.
abstract: In the present study, the effects of compounds extracted from Tanacetum microphyllum, four flavonoids and one sesquiterpene lactone, on arachidonic acid metabolism in cellular systems were examined. In the PGE2- and LTC4-release assay, most compounds did not exhibit any significant effect. Only hydroxyachillin, and the flavonoids centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol showed a significant effect, although with less potency than the reference drugs, indomethacin and NDGA. However, all compounds inhibited the release of TXB2 from ionophore-stimulated human platelets. The action is more marked with the flavonoids santin and ermanin.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.
authors.forename: A M
authors.initials: AM
authors.lastname: Silván
authors.forename: M J
authors.initials: MJ
authors.lastname: Abad
authors.forename: P
authors.initials: P
authors.lastname: Bermejo
authors.forename: A
authors.initials: A
authors.lastname: Villar
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D019659:Asteraceae / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D013931:Thromboxanes / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D013931:Thromboxanes; D016718:Arachidonic Acid