Expression of interleukin-8 in human glomerulonephritis.
Interleukin-8 (IL-8) is a cytokine, which possesses both chemotactic and activating properties for neutrophils, lymphocytes and basophils. Various evidence has indicated IL-8 to be implicated in the pathophysiology of immune-mediated renal diseases. We thus examined the expression of IL-8 in renal diseases. We detected the expression of IL-8 both in mRNA and the protein levels in renal biopsy specimens obtained from patients with IgA nephropathy and lupus nephritis. A significant correlation was found between the expression of IL-8 mRNA and the number of neutrophils in the glomerulus. We also found a negative correlation between the expression of IL-8 mRNA and creatinine clearance. Our study thus suggested IL-8 to be involved in the pathophysiology of proliferative glomerulonephritis.
Sekikawa
T
T
Department of Medicine III, Okayama University Medical School, Japan.
Kashihara
N
N
Maruyama
K
K
Satoh
M
M
Okamoto
K
K
Kanao
K
K
Maeshima
Y
Y
Sugiyama
H
H
Yamasaki
Y
Y
Makino
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005921:Glomerulonephritis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis* / Q000235:genetics; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D012333:RNA, Messenger / Q000096:biosynthesis
D016209:Interleukin-8; D012333:RNA, Messenger