title: Synthesis of oligodeoxyribonucleotide containing novel C-5 reactive 2'-deoxyuridine derivative and its functional modification via post-synthetic technique.
abstract: 2'-Deoxyuridine derivatives bearing an activated ester at C-5 position were synthesized and was examined their use for the preparation of modified oligodeoxyribonucleotides (ODNs) by a post-modification method. The ODNs containing cyanomethyl ester at C-5 position of the deoxyuridine residue reacted easily with a primary amine of several functional molecules under the mild condition to give the corresponding modified ODNs.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Gunma University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kohgo
authors.forename: A
authors.initials: A
authors.lastname: Umeda
authors.forename: H
authors.initials: H
authors.lastname: Ozaki
authors.forename: K
authors.initials: K
authors.lastname: Shinozuka
authors.forename: H
authors.initials: H
authors.lastname: Sawai
mesh_terms: D001483:Base Sequence; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D003857:Deoxyuridine