Plasma thromboxane B2 concentration in patients with ventricular septal defect and pulmonary hypertension.
Plasma thromboxane B2 (TXB2)-a stable metabolite of thromboxane A2 (TXA2)-conventional hemodynamic parameters, mean pulmonary input energy (input energy), and mean pulmonary output energy (output energy) were measured to assess platelet activation in 21 patients with pulmonary hypertension and a ventricular septal defect (VSD). The patients were divided into 2 groups: group A (normal range) and group B (high level). TXB2 levels were measured by radioimmunoassay. There was no relationship between plasma TXB2 concentrations and conventional hemodynamic parameters except the pulmonary-to-systemic pressure ratio. Output-to-input energy ratio was correlated logarithmically with the plasma TXB2 concentration. We concluded that patients with output/input energy ratio >0.15 had a high TXB2 concentration and activated platelets in pulmonary capillaries.
Fuse
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Department of Pediatrics, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Tomita
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Chiba
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D001794:Blood Pressure; D002675:Child, Preschool; D006345:Heart Septal Defects, Ventricular / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D007223:Infant; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2