Novel molecular and cellular strategies in cancer therapy.
Tumor initiation and progression results from several subsequent mutations in genes that control cellular proliferation and differentiation. Neoplasia may lead to the expression of antigens that may be derived from such oncogenes or the activation of other cellular or viral genes that may represent tumor associated antigens. This review summarizes the present understanding of these mechanisms in an effort to design new therapeutic strategies.
Köhler
G
G
Department of Pathology, University of Freiburg, Germany.
Albrecht
B
B
Fisch
P
P
D003713:Dendritic Cells / Q000276:immunology; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D009857:Oncogenes; D019444:Vaccines, DNA / Q000276:immunology
D019444:Vaccines, DNA