title: [A patient with an ACTH-releasing thymic carcinoid tumor presenting with proximal muscle weakness].
abstract: We report a 36-year-old man with proximal dominant muscle weakness, thymic tumor, diabetes mellitus, hypokalemia, and increased levels of plasma ACTH and cortisol. The diagnosis of carcinoid tumor was made on the basis of pathological findings in the biopsied specimen of the thymic tumor. The proximal muscle weakness was considered to be due to steroid myopathy resulting from the overproduction of cortisol from the adrenal glands induced by the ectopic ACTH secreted by the thymic carcinoid tumor. Although thymoma in frequently associated with myasthenia gravis, we should also consider carcinoid tumors in patients with a thymic tumor presenting with a proximal muscle weakness.
authors.affiliation: Department of Neurology, Niigata University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Idezuka
authors.forename: R
authors.initials: R
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Kuwabara
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000503:physiopathology; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D008297:Male; D018908:Muscle Weakness / Q000209:etiology*; D013953:Thymus Neoplasms / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D006729:Hormones, Ectopic; D000324:Adrenocorticotropic Hormone