title: [Infection without infection focus--clinical relevance of bacterial translocation].
abstract: The passage of bacteria, fungi, and bacterial products through the gut wall, which is called microbial translocation, is an experimentally well-defined process occurring during burn injury, multiple trauma, and septic diseases. The translocation of viable bacteria could be demonstrated in humans as a sporadic event, but despite accumulating evidence the clinical relevance remains to be elucidated. The same fact is true for the translocation of bacterial products such as endotoxin. Although a large body of evidence supports the hypothesis that endotoxin of gut origin may play a pathophysiologically important role, general acceptance is still lacking because some clinical studies provide disappointing results due to unrecognized methodological problems.
authors.affiliation: Chirurgische Klinik I, Universität Ulm.
authors.forename: D
authors.initials: D
authors.lastname: Berger
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology*; D018988:Bacterial Translocation / Q000502:physiology*; D004731:Endotoxins / Q000097:blood; D006801:Humans; D010538:Peritonitis / Q000382:microbiology*; D012772:Shock, Septic / Q000382:microbiology*
chemical_list: D004731:Endotoxins
vernacular_title: Sepsis ohne Sepsisherd--Klinische Relevanz der bakteriellen Translokation.