title: Guidelines for antithrombotic therapy in pediatric patients.
abstract: Because of the relatively low incidence of TEs in children, the diagnostic and therapeutic approaches used are largely extrapolated from guidelines for adults. Features that differ in children compared with adults include underlying disorders, high incidence of CVL-related DVT in the upper venous system, and response to SH, warfarin, and thrombolytic agents. There is a paucity of information on the risk/benefit ratio of the therapeutic interventions and long-term outcome. Clinical trials are urgently needed to clarify optimal management for pediatric patients with TEs.
authors.affiliation: Hamilton Civic Hospitals Research Centre, Henderson General Division, Ontario, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Andrew
authors.forename: A D
authors.initials: AD
authors.lastname: Michelson
authors.forename: E
authors.initials: E
authors.lastname: Bovill
authors.forename: M
authors.initials: M
authors.lastname: Leaker
authors.forename: M P
authors.initials: MP
authors.lastname: Massicotte
mesh_terms: D015984:Causality; D002648:Child; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D017410:Practice Guidelines as Topic; D013923:Thromboembolism / Q000188:drug therapy* / Q000453:epidemiology; D015912:Thrombolytic Therapy
chemical_list: D005343:Fibrinolytic Agents