Potential role of rhIGF-I/IGFBP-3 in maintaining skeletal mass in space.
Bone loss during space flight may be induced by decreased activity of bone formation. To explore a new method for the bone loss in microgravity, the effects of insulin-like growth factor I (IGF-I), a potent stimulator for osteoblast activities, were studied in in vitro and in vivo system. The complex of IGF-I and its specific binding protein, IGFBP-3, may stimulate the osteoblastic activities via prolonged serum half life and increased cellular association of IGF-I. In an ovariectomy combined with neurectomy model, this complex stimulated bone turnover. IGF-I/IGFBP-3 may be a candidate for the treatment of bone loss induced by the microgravity.
Tanaka
H
H
Department of Pediatrics, Okayama University Medical School, Japan. hrtanaka@hospital.okayama-u.ac.jp
Moriwake
T
T
Matsuoka
Y
Y
Nakamura
T
T
Seino
Y
Y
D000818:Animals; D015519:Bone Density; D001846:Bone Development / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division; D002478:Cells, Cultured; D004338:Drug Combinations; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000494:pharmacology / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology / Q000502:physiology*; D010006:Osteoblasts / Q000187:drug effects; D011994:Recombinant Proteins; D013026:Space Flight; D014893:Weightlessness
D004338:Drug Combinations; D018972:Insulin-Like Growth Factor Binding Protein 3; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I