Synthesis of bis-netropsin-linked hydroxamic acids and their DNA cleavage properties in the presence of transition or lanthanide metal ions.
Nobel hydroxamic acids containing bis-netropsin units coupled by polymethylenetether (BNHA) have been synthesized. BNHA-ferrous complexes sequence-specifically cleaved pBR322 DNA fragment whereas corresponding cerium complexes showed low-sequence specific cleavage pattern.
Hashimoto
S
S
Department of Biological Science and Technology, Science University of Tokyo, Noda, Japan.
Itai
K
K
Takeuchi
Y
Y
Nakamura
Y
Y
D001483:Base Sequence; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D008674:Metals, Rare Earth / Q000494:pharmacology*; D015394:Molecular Structure; D009429:Netropsin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D010957:Plasmids / Q000187:drug effects*
C113075:5-(2-(2-(2-(2-(dimethylaminoethylaminocarbonyl)-1-methylpyrrol-4-yl)aminocarbonyl-1-methylpyrrol-4-yl)aminocarbonylethylaminocarbonyl-1-methylpyrrol-4-yl)aminocarbonyl-1-methylpyrrol-4-yl)aminocarbonylpentahydroxamic acid; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D008674:Metals, Rare Earth; D009838:Oligodeoxyribonucleotides; D009429:Netropsin; C032161:bis-netropsin