title: LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.
abstract: Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.
authors.affiliation: Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology, and Faculté de Médecine, Université Catholique de Louvain, B-1200 Brussels, Belgium.
authors.forename: M R
authors.initials: MR
authors.lastname: Sarker
authors.forename: M P
authors.initials: MP
authors.lastname: Sory
authors.forename: A P
authors.initials: AP
authors.lastname: Boyd
authors.forename: M
authors.initials: M
authors.lastname: Iriarte
authors.forename: G R
authors.initials: GR
authors.lastname: Cornelis
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001427:Bacterial Toxins / Q000378:metabolism; D001692:Biological Transport; D003603:Cytotoxins / Q000378:metabolism; D005057:Eukaryotic Cells / Q000382:microbiology; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D009154:Mutation; D052899:Pore Forming Cytotoxic Proteins; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D015008:Yersinia enterocolitica / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D003603:Cytotoxins; C088009:LcrG protein, Yersinia; D052899:Pore Forming Cytotoxic Proteins; C063239:yopE protein, Yersinia; D017027:Protein Tyrosine Phosphatases; C067571:yopH protein, Yersinia