Army and Air Force leadership in the Prostate Cancer Prevention Trial.
Prostate cancer is now the most common solid tumor in men in the United States. Although the current public health approach to this disease is early diagnosis and treatment, investigations are also focusing on the possibility of disease prevention. The Prostate Cancer Prevention Trial, begun in 1993, has completed recruitment of 18,000 men who will be randomized to receive either finasteride or placebo to determine if finasteride can prevent the development of this disease. Both Army and Air Force institutions are participating in this trial, with four Department of Defense institutions contributing over 10% of the patients randomized. The results of this study may have a major impact on active duty personnel for whom prevention of prostate cancer may become possible.
Allerton
J
J
Department of Hematology/Oncology, Wilford Hall Medical Center, San Antonio, Texas, USA.
Seay
T
T
Optenberg
S
S
Coltman
C A
CA
Higgins
B
B
Thompson
I
I
Lovato
L
L
D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D018120:Finasteride / Q000627:therapeutic use*; D006801:Humans; D007857:Leadership; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D011471:Prostatic Neoplasms / Q000517:prevention & control*; D014481:United States
D004791:Enzyme Inhibitors; D018120:Finasteride