title: Lower oesophageal sphincter tone increases after induction of anaesthesia in pigs with full stomach.
abstract: OBJECTIVE
  The lower oesophageal sphincter (LOS) is the man mechanism that prevents gastro-oesophageal regurgitation during anaesthesia. The aim of this study was to assess the effect on lower oesophageal sphincter pressure (LOSP) of rapid sequence induction in pigs with full stomachs.
  
  
  METHODS
  Lower oesophageal sphincter pressure and oesophageal barrier pressure (BrP = LOSP minus gastric pressure) were measured using a water-perfused manometric catheter method in 12 pigs after gastric filling with 500 ml of liquid nutrient mixture. Six pigs were randomly allocated to receive 5 mg.kg-1 propofol and 3 mg.kg-1 succinylcholine i.v. and six pigs received 8 mg.kg-1 thiopentone and 3 mg.kg-1 succinylcholine i.v.
  
  
  RESULTS
  After induction, mean LOSP increased during the period with fasciculations from 19 +/- 4 mmHg to 28 +/- 5 mmHg in the propofol-succinylcholine group and from 23 +/- 6 mmHg to 36 +/- 7 mmHg in the thiopentone-succinylcholine group. The LOSP remained elevated after the fasciculations. LOSP and BrP were not different between the groups.
  
  
  CONCLUSIONS
  Induction of anaesthesia with propofol-succinylcholine or thiopentone-succinylcholine increases LOSP and, consequently, BrP in pigs with a full stomach. This increase begins before fasciculations and remains elevated for the period when intubation would occur.
authors.affiliation: Service d'Anesthésie-Réanimation Hôpital de l'Hôtel-Dieu, Lyon, France. jptourna@univ-lyon1.fr
authors.forename: J P
authors.initials: JP
authors.lastname: Tournadre
authors.forename: M
authors.initials: M
authors.lastname: Barclay
authors.forename: P
authors.initials: P
authors.lastname: Boulétreau
authors.forename: D
authors.initials: D
authors.lastname: Chassard
mesh_terms: D000758:Anesthesia; D000818:Animals; D004943:Esophagogastric Junction / Q000502:physiology*; D011312:Pressure; D015742:Propofol / Q000494:pharmacology; D013390:Succinylcholine / Q000494:pharmacology; D013552:Swine; D013874:Thiopental / Q000494:pharmacology
chemical_list: D013390:Succinylcholine; D013874:Thiopental; D015742:Propofol