title: Tritherapy for human immunodeficiency virus infection does not modify replication of hepatitis C virus in coinfected subjects.
abstract: Triple antiretroviral therapy combining reverse transcriptase and protease inhibitors modifies the prognosis for human immunodeficiency virus (HIV) infection, with dramatic improvement in immune status. In an attempt to evaluate the impact of anti-HIV triple combination therapy on the course of hepatitis C virus (HCV)-related chronic hepatitis and on HCV replication, we studied the biological and virological characteristics of 22 HCV/HIV-coinfected patients who were given triple combination therapy. In comparison with baseline values, there was (1) a significant increase in the CD4 and CD8 cell counts and a decrease in the HIV RNA load and (2) no significant variation in aminotransferase activities or the HCV RNA load at 3, 6, or 9 months of tritherapy. Antiretroviral tritherapy seems to modify neither the biological activity of HCV-related chronic hepatitis nor the HCV load, despite immune restoration. Hepatic histopathologic analysis is warranted to assess the impact of immune restoration on liver lesions.
authors.affiliation: Unité d'Hépatologie, Hôpital Necker, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Zylberberg
authors.forename: M L
authors.initials: ML
authors.lastname: Chaix
authors.forename: C
authors.initials: C
authors.lastname: Rabian
authors.forename: C
authors.initials: C
authors.lastname: Rouzioux
authors.forename: B
authors.initials: B
authors.lastname: Aulong
authors.forename: C
authors.initials: C
authors.lastname: Bréchot
authors.forename: J P
authors.initials: JP
authors.lastname: Viard
authors.forename: S
authors.initials: S
authors.lastname: Pol
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D016174:Hepacivirus / Q000187:drug effects* / Q000502:physiology; D006526:Hepatitis C / Q000150:complications* / Q000821:virology*; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load; D014766:Viremia / Q000188:drug therapy / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral; D000410:Alanine Transaminase