title: Successful treatment with voriconazole of invasive aspergillosis in chronic granulomatous disease.
abstract: A 5-year-old boy with chronic granulomatous disease (CGD) was treated with amphotericin B for an invasive pulmonary Aspergillus nidulans infection. The infection progressed during 6 wk of treatment despite the addition of interferon-gamma (IFN-gamma), filgrastim, and transfusions with donor granulocytes. Treatment with a novel antifungal triazole, voriconazole, resulted in an excellent clinical response.
authors.affiliation: Department of Pediatric Intensive Care, University Hospital Nijmegen, The Netherlands.
authors.forename: L G
authors.initials: LG
authors.lastname: van 't Hek
authors.forename: P E
authors.initials: PE
authors.lastname: Verweij
authors.forename: C M
authors.initials: CM
authors.lastname: Weemaes
authors.forename: R
authors.initials: R
authors.lastname: van Dalen
authors.forename: J B
authors.initials: JB
authors.lastname: Yntema
authors.forename: J F
authors.initials: JF
authors.lastname: Meis
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy*; D001233:Aspergillus nidulans; D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole