Mechanisms of latency in Mycobacterium tuberculosis.
Mycobacterium tuberculosis can persist within the human host for years without causing disease, in a syndrome known as latent tuberculosis (TB). As one-third of the world population has latent TB, placing them at risk for active TB, the mechanisms by which M. tuberculosis establishes a latent metabolic state, eludes immune surveillance and responds to triggers that stimulate reactivation are a high priority for the future control of TB.
Parrish
N M
NM
Dept of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205-2179, USA.
Dick
J D
JD
Bishai
W R
WR
D000818:Animals; D004195:Disease Models, Animal; D005798:Genes, Bacterial / Q000502:physiology; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000382:microbiology*