The calcium store in the nuclear envelope.
The nuclear envelope has a relatively small volume, but is connected up to the vastly larger endoplasmic reticulum. The Ca2+ concentration in the lumen of the interconnected nuclear envelope and endoplasmic reticulum network is in the resting state maintained at a level of more than 100 microM. There are specific Ca2+ release channels present in the inner nuclear membrane that can be activated by inositol trisphosphate or cADP ribose. The system, therefore, allows selective release of Ca2+ into the nucleoplasm which could be important for the control of specific types of gene expression.
Petersen
O H
OH
MRC Secretory Control Research Group, Physiological Laboratory, University of Liverpool, UK.
Gerasimenko
O V
OV
Gerasimenko
J V
JV
Mogami
H
H
Tepikin
A V
AV
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D009685:Nuclear Envelope / Q000378:metabolism*
D015220:Calcium Channels; D000252:Calcium-Transporting ATPases; D002118:Calcium