[New means for the prophylaxis of colon cancer with the use of beta-glucuronidase inhibitors].
Experiments involving the use of 1,2-dimethylhydrazine-induced colonic tumors in rats showed long-term treatment with a newly synthesized drug EDE-10g to inhibit an enzyme of enteric beta-glucuronidase, to suppress carcinogenesis and to prolong lifespan of animals.
Pliss
G B
GB
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Vlasov
N N
NN
Anikin
I V
IV
D019813:1,2-Dimethylhydrazine; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005966:Glucuronidase / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D016019:Survival Analysis
D016588:Anticarcinogenic Agents; D005966:Glucuronidase; D019813:1,2-Dimethylhydrazine
Novye vozmozhnosti profilaktiki raka kishechnika s ispol'zovaniem preparatov - ingibitorov beta-gliukuronidazy.