Successful treatment with voriconazole of invasive aspergillosis in chronic granulomatous disease.
A 5-year-old boy with chronic granulomatous disease (CGD) was treated with amphotericin B for an invasive pulmonary Aspergillus nidulans infection. The infection progressed during 6 wk of treatment despite the addition of interferon-gamma (IFN-gamma), filgrastim, and transfusions with donor granulocytes. Treatment with a novel antifungal triazole, voriconazole, resulted in an excellent clinical response.
van 't Hek
L G
LG
Department of Pediatric Intensive Care, University Hospital Nijmegen, The Netherlands.
Verweij
P E
PE
Weemaes
C M
CM
van Dalen
R
R
Yntema
J B
JB
Meis
J F
JF
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy*; D001233:Aspergillus nidulans; D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole