Epoxyquinomicins A, B, C and D, new antibiotics from Amycolatopsis. III. Physico-chemical properties and structure determination.
The structures of epoxyquinomicins A (1), B (2), C (3) and D (4) were determined by spectroscopic studies. Compound 1 was determined to be (5R,6S)-2-(3-chloro-2-hydroxybenzoylamino)-5-hydroxymethyl-5,6-epo xy- 2-cyclohexene-1,4-dione. Compound 2 was revealed to be the dechlorinated derivative of 1. Compounds 3 and 4 were determined to be the reduced derivative of 2 and 1, respectively.
Matsumoto
N
N
Institute of Microbial Chemistry, Tokyo, Japan.
Tsuchida
T
T
Sawa
R
R
Iinuma
H
H
Nakamura
H
H
Naganawa
H
H
Sawa
T
T
Takeuchi
T
T
D039903:Actinobacteria / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D011809:Quinones / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001549:Benzamides; D011809:Quinones; C099341:epoxyquinomicin A; C099342:epoxyquinomicin B; C111288:epoxyquinomicin C; C111289:epoxyquinomicin D