title: Antipneumococcal activity of grepafloxacin compared to that of other agents by time-kill methodology.
abstract: Time-kill studies compared the activities of grepafloxacin with those of ciprofloxacin, levofloxacin, sparfloxacin, amoxicillin-clavulanate, and clarithromycin against 12 pneumococcal strains. Grepafloxacin was bactericidal after 24 h against all strains at a concentration of < or = 0.5 microg/ml, while sparfloxacin, levofloxacin, and ciprofloxacin were bactericidal at concentrations of < or = 1.0, < or = 2.0, and < or = 8.0 microg/ml, respectively. Amoxicillin-clavulanate and clarithromycin were bactericidal at 2x the MIC after 24 h against 12 of 12 strains and against all 8 macrolide-susceptible strains, respectively.
authors.affiliation: Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Pankuch
authors.forename: M R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: P C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D015363:Quinolones / Q000008:administration & dosage / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D018942:Macrolides; D010879:Piperazines; D015363:Quinolones; C075375:grepafloxacin