title: Structure-activity relationships of some complex I inhibitors.
abstract: A wide variety of complex I inhibitors act at or close to the ubiquinone reduction site. Identification of the structural factors required for exhibiting inhibitory actions on the basis of structure-activity relationships is useful to elucidate the manner in which inhibitors interact with the enzyme. This review summarizes studies on the structure-activity relationship of rotenoids, piericidins, capsaicins, pyridinium-type inhibitors and modern synthetic agrochemicals acting at mitochondrial complex I.
authors.affiliation: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-01, Japan. miyoshi@kais.kyoto-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Miyoshi
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D016660:NAD(P)H Dehydrogenase (Quinone)