[Does preoperative corticoid administration reduce the incidence of acute rejections after kidney transplantation?].
Primary immunosuppressive therapy in renal transplantation is mediated by glucocorticosteroids with a delay of several hours. Consequence of the common practice of using first dose of steroids intraoperatively is a first contact of antigens with an unaltered immune system. In a prospective study on 111 renal transplant patients, we could show by the parameters of in vitro cytokine generation and acute rejection episodes that immunological responsiveness can be altered by early (5 h) preoperative use of glucocorticosteroids.
Strik
M W
MW
Kliniken für Chirurgie, Innere Medizin I, Medizinische Universität zu Lübeck.
Klüter
H
H
Hoyer
J
J
Bruch
H P
HP
Sack
K
K
Fricke
L
L
D000328:Adult; D016207:Cytokines / Q000097:blood; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies
D016207:Cytokines; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D008775:Methylprednisolone
Reduziert die präoperative Kortikoidapplikation die Inzidenz akuter Abstossungen nach Nierentransplantation?