Comparative pharmacokinetics of sulfamethazine in plasma and parotid saliva of sheep.
Salivary output in sheep is large enough to be considered a physiologic body fluid compartment. The hypothesis for this work was that pharmacokinetics of sulfamethazine in saliva was similar to that in plasma. A reliable technique was developed to measure parotid salivary output. Mean output of saliva was 3.18 +/- 1.04 L from a single parotid gland per day with a mean flow of 2.21 +/- 0.43 mL/min. Using concentrations of sulfamethazine in parotid saliva made it possible to calculate the total passage of sulfamethazine to parotid saliva, which was calculated to be 3.5% of the total dose. Pharmacokinetic variables obtained for sulfamethazine in plasma and in saliva were closely related (AUC 1408 micrograms.h/mL and AUC 1484 micrograms.h/mL; Vdarea 0.434 L/kg and Vdarea 0.374 L/kg; t 1/2 beta 4.30 h and 3.46 h, respectively) and no substantial differences were observed. The convenience of using salivary concentrations of sulfamethazine for drug monitoring is discussed.
Pulido
E
E
Departement de Physiologie, Ecole Nationale Vétérinaire de Lyon, France.
Meot
F
F
Sumano
H
H
Boivin
R
R
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D010306:Parotid Gland / Q000378:metabolism; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012756:Sheep / Q000378:metabolism*; D013418:Sulfamethazine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D013418:Sulfamethazine