title: Solid phase synthesis of combinatorial libraries using anhydrides as templates.
abstract: A simple and general approach to the synthesis of chemical libraries based on a universal anhydride template allows the preparation of large number of compounds. Various cyclic/acyclic amines, primary/secondary amines, differentially protected bifunctional amines were used as nucleophiles to react with anhydrides. The free carboxylic acid generated was then coupled with solid-bound amines. The facile and rapid generation of compounds through this multi-component assembly can be accomplished in a combinatorial parallel synthesis.
authors.affiliation: Scios Inc., Sunnyvale, CA 94086, USA. perumattam@sciosinc.com
authors.forename: J
authors.initials: J
authors.lastname: Perumattam
authors.forename: S
authors.initials: S
authors.lastname: Chakravarty
authors.forename: G A
authors.initials: GA
authors.lastname: McEnroe
authors.forename: R R
authors.initials: RR
authors.lastname: Goehring
authors.forename: B
authors.initials: B
authors.lastname: Mavunkel
authors.forename: S
authors.initials: S
authors.lastname: Suravajjala
authors.forename: W W
authors.initials: WW
authors.lastname: Smith
authors.forename: B
authors.initials: B
authors.lastname: Chen
mesh_terms: D000215:Acylation; D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000378:metabolism; D000812:Anhydrides / Q000737:chemistry*; D005449:Fluorenes / Q000378:metabolism; D015394:Molecular Structure; D012116:Resins, Plant
chemical_list: D000577:Amides; D000588:Amines; D000596:Amino Acids; D000812:Anhydrides; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D012116:Resins, Plant