Preclinical oral toxicology in rats of D-002, a natural drug with antiulcer effects.
D-002 is a mixture of higher aliphatic primary alcohol isolated from bees wax (Apis mellifera) with effective antiulcer effects demonstrated in different experimental models. Oral toxicity of D-002 (5-5000 mg/kg) was evaluated in sub-acute (14 days), subchronic (90 days) and chronic (1 year) studies in Sprague-Dawley rats from both sexes. There was no treatment-related toxicity. Thus, effects on body weight, food consumption, clinical observations, blood parameters, organ weight ratios and histopathological findings were similar in control and treated groups. These short and long-term studies support a wide safety margin for this product.
Rodeiro
I
I
Center of Natural Products, National Center for Scientific Research, Havana City, Cuba.
Alemán
C
C
Noa
M
M
Menéndez
R
R
Más
R
R
Hernández
C
C
Garcia
M
M
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000633:toxicity*; D001012:Aorta, Abdominal / Q000187:drug effects / Q000378:metabolism; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism
D000897:Anti-Ulcer Agents; C104511:D 002; D005233:Fatty Alcohols