title: Isolation and structure elucidation of an intermediate in the photodegradation of ciprofloxacin.
abstract: Ciprofloxacin decomposes photochemically in aqueous solutions at acidic pH forming two major degradation products. One of the products, isolated from irradiated solutions by flash chromatography, was 7-[(2-aminoethyl)amino]-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-3-quinoline carboxylic acid. The compound was an intermediate in the photochemical process, which degraded after longer exposure with a high-pressure mercury lamp to an aromatic amino-compound, 7-amino-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-3-quinoline carboxylic acid. The structure of the intermediate was elucidated on the basis of information from ultraviolet, mass and nuclear magnetic resonance spectra.
authors.affiliation: Turku University Central Hospital, Hospital Pharmacy, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Torniainen
authors.forename: C P
authors.initials: CP
authors.lastname: Askolin
authors.forename: J
authors.initials: J
authors.lastname: Mattinen
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000528:radiation effects; D002939:Ciprofloxacin / Q000737:chemistry* / Q000302:isolation & purification* / Q000528:radiation effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin