[Effect of inhaled nitric oxide on endotoxin induced acute lung injury in rabbit].
OBJECTIVE
In order to observe the effects of inhaling nitric oxide (NO) on acute lung injury (ALI).


METHODS
24 rabbits divided into 4 groups. Six rabbits injured with intravenous E. Coli endotoxin, then followed by treatment of inhaling 80 ppm NO in inspired gas. Before and after the infusion of endotoxin, the mean pulmonary arterial pressure (mPAP), mean systemic arterial pressure (mPSA) and the PaO2 were examined. The venous methemoglobin (MHb) was measured by using spectrophometer colorimitry. The extravasculur lung water was evaluated with rate of dried to wet lung weight at the end of study.


RESULTS
The rabbits injured with endotoxin inhaling 80 ppm NO could rapidly reduce the mPAP, increase the PaO2 and without inducing significant change of mPSA, MHb and extravasculur lung water.


CONCLUSIONS
Inhalation of 80 ppm NO can selectively cause pulmonary artery dilatation, reduce mPAP, improve pulmonary gas exchange, without producing system vasodilation and toxic effects to the rabbits.
Liao
J
J
Respiratory Department, Xijing Hospital, Fourth Military Medical University, Xian.
Li
H
H
Qi
H
H
D000280:Administration, Inhalation; D000818:Animals; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D008297:Male; D009569:Nitric Oxide / Q000627:therapeutic use*; D011817:Rabbits; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy*
D004731:Endotoxins; D009569:Nitric Oxide