Incidence and clinical manifestations of activated protein C resistance and factor V Leiden in young patients with venous thromboembolic disease in Spain.
In order to evaluate the actual incidence and clinical repercussion of activated protein C resistance (APCR) in our area, we performed a coagulation and thrombophillic study on 65 young patients diagnosed with deep vein thrombosis and 53 controls. Family and genetic study was carried out in APC-resistant patients. We found APCR in 26.15% of patients and the 77.7% of these and their relative were heterozygous for factor V Leiden. There's a clear relationship between phenotype APCR and thrombosis, and also between factor V Leiden and thrombosis.
Olave
T
T
Cornudella
R
R
Homs
C
C
Azaceta
G
G
Tirado
I
I
Gutierrez
M
M
D000293:Adolescent; D000328:Adult; D004351:Drug Resistance; D005165:Factor V / Q000502:physiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011486:Protein C / Q000502:physiology*; D013030:Spain / Q000453:epidemiology; D013924:Thrombophlebitis / Q000453:epidemiology* / Q000503:physiopathology*
D011486:Protein C; C095381:factor V Leiden; D005165:Factor V