The role of glycoproteins in neural development function, and disease.
Glycoproteins play key roles in the development, structuring, and subsequent functioning of the nervous system. However, the complex glycosylation process is a critical component in the biosynthesis of CNS glycoproteins that may be susceptible to the actions of toxicological agents or may be altered by genetic defects. This review will provide an outline of the complexity of this glycosylation process and of some of the key neural glycoproteins that play particular roles in neural development and in synaptic plasticity in the mature CNS. Finally, the potential of glycoproteins as targets for CNS disorders will be discussed.
Breen
K C
KC
Neurosciences Institute, Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital Medical School, Scotland, UK.
Coughlan
C M
CM
Hayes
F D
FD
D000818:Animals; D002240:Carbohydrate Sequence; D002454:Cell Differentiation / Q000502:physiology; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009420:Nervous System / Q000254:growth & development* / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism* / Q000503:physiopathology*
D006023:Glycoproteins