Acute effect of trandolapril on serum erythropoietin in uremic and hypertensive patients.
Anemia associated with ACE inhibitors is rare but it may cause problems especially in patients with renal disease. This study assessed the acute effect of trandolapril, an ACE inhibitor, on serum erythropoietin (EPO) levels in uremic and hypertensive patients. Trandolapril 2 mg/day was given orally for three days and blood samples were collected on the first and third day. Trandolapril led to a significant decrease in serum EPO in patients with chronic renal failure. Although the drug lowered serum EPO in hypertensive patients, this effect was not statistically significant. This drop in serum EPO levels may be one of the mechanisms by which ACE inhibitors cause anemia, or worsen anemia, in uremic patients and further studies are needed to clarify this point.
Akpolat
T
T
Ondokuz Mayis University, School of Medicine, Department of Nephrology, Samsun, Turkey.
Gumus
T
T
Bedir
A
A
Adam
B
B
D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014511:Uremia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; D004921:Erythropoietin; C052035:trandolapril