[An observation on calcium ion overloaded injury and the effect of calcium channel blocker in rabbit retina under acute ocular hypertension].
OBJECTIVE
In order to observe the retinal injury by Ca+2 overload under ocular hypertension and the effect of verapamil treatment.


METHODS
Atomic absorption spectrophotometry and phosphate pyroantemonate (PPA) means were used to observe the changes of rabbit retinal Ca+2 content and the therapeutic effects of verapamil under this situation.


RESULTS
In the ocular hypertensive group, Ca+2 increased from the moment of intraocular pressure elevation, and with prolongation of time, it tended to increase steadily. In comparison with the control group, there were significant differences (P < 0.01). PPA showed that the longer the time, the more obvious swollen the mitochondria and much more calcium deposition in the mitochondria. In the group of rabbits with ocular hypertension having taken verapamil treatment, the Ca+2 content was markedly lower, the changes of mitochondria milder and the Ca+2 deposition in mitochondria less than that of the ocular hypertension group without treatment.


CONCLUSIONS
Calcium-overload may be one of the reasons of retinal injury under ocular hypertension, while calcium-blocker may alleviate this injury.
Ji
J
J
Department of Ophthalmology, Qingdao Medical College.
Sun
W
W
Cheng
D
D
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D005260:Female; D008297:Male; D008933:Mitochondrial Swelling; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000378:metabolism; D011817:Rabbits; D012160:Retina / Q000378:metabolism*; D014700:Verapamil / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D014700:Verapamil; D002118:Calcium