Preoperative GnRH analogue in hysteroscopic metroplasty.
OBJECTIVE
To evaluate the effectiveness of Gonadotropin-Releasing Hormone analogue when administered preoperatively in hysteroscopic metroplasty.


METHODS
Prospective, comparative study.


METHODS
Sixty patients undergoing hysteroscopic metroplasty for septate uterus who were randomly allocated to pretreatment with two injections monthly of Gonadotropin-Releasing Hormone analogue or to no pretreatment. To assess the outcome of surgery three parameters were used: operative time (minutes), fluid adsorption (ml) and intraoperative bleeding.


RESULTS
No significant differences in the operating time (21.9 vs 22.9 min), fluid adsorption (395 ml, range 200-550 vs 515 ml, range 250-650), intraoperative bleeding and failure rate were found between pretreated patients and controls.


CONCLUSIONS
Preoperative treatment with Gonadotropin-Releasing Hormone analogue showed no advantage in hysteroscopic treatment of mullerian defects, but only an improvement, not statistically significant, in term of reduced operative time and fluid adsorption.
Colacurci
N
N
Department of Gynaecology and Obstetrics, School of Medicine, Second University of Naples, Italy.
de Franciscis
P
P
Mollo
A
A
Mele
D
D
Fortunato
N
N
Zarcone
R
R
D000328:Adult; D005260:Female; D017273:Goserelin / Q000627:therapeutic use*; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D015907:Hysteroscopy; D011446:Prospective Studies; D014599:Uterus / Q000002:abnormalities* / Q000187:drug effects / Q000601:surgery*
D017273:Goserelin