Estrogen and cancellous bone loss in the fowl.
Female birds model a type of woven bone prior to egg laying which is known as medullary bone. Medullary bone modeling is estrogen dependent and in the female fowl coincides with a decrease in cancellous bone volume. Medullary bone modeling was induced in male laying-strain fowl by the administration of estrogen and prevented in females by the administration of tamoxifen. In estrogen-treated males, medullary bone modeling was accompanied by cancellous bone loss; cancellous bone volume was significantly lower than in control males (P < 0.001). In females, the prevention of medullary bone modeling by tamoxifen treatment resulted in significantly higher cancellous bone volumes than in control females (P < 0.001). Estrogen therefore appears to play a role in cancellous bone loss in the fowl.
Wilson
S
S
Roslin Institute, Roslin, Midlothian, Scotland EH25 9PS.
Thorp
B H
BH
D000818:Animals; D001835:Body Weight; D001862:Bone Resorption / Q000517:prevention & control*; D001842:Bone and Bones / Q000187:drug effects* / Q000502:physiology; D004965:Estrogen Antagonists / Q000008:administration & dosage*; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D008297:Male; D011200:Poultry; D012098:Reproduction; D013629:Tamoxifen / Q000008:administration & dosage*
D004965:Estrogen Antagonists; D004967:Estrogens; D013629:Tamoxifen