[Magnesium and calcium changes in serum and atrial muscle caused by open heart surgery and the effect of preoperative oral magnesium administration].
The study was undertaken to compare magnesium and calcium serum concentration levels and magnesium and calcium atrial muscle content of between the non-magnesium group (20 patients) and the magnesium group (11 patients) in the perioperative period of open heart surgery. In addition, the incidence of arrhythmias was compared between the two groups. Late ventricular potentials and postoperative ventricular arrhythmias were evaluated in both groups. The patients of the magnesium group were administered a daily oral intake of 3.0 g of magnesium oxide for ten days before operation. In both groups, serum concentration of magnesium decreased abruptly due to hemodilution after the operation and began increasing gradually from 24 hours after the operation. However, in the non-magnesium group the concentration decreased below the normal range in the 24 hour period after the operation and elevated to above the preoperative value from the third to fifth postoperative days. In the magnesium group serum concentration of magnesium was higher during the 24 hours after the operation and lower from the third to fifth postoperative days than the non-magnesium group. Thus, the fluctuation was smaller in the magnesium group than the non-magnesium group. Serum concentration of calcium also decreased abruptly after the operation and gradually increased in the postoperative days in both groups. However, the level was always higher in the magnesium group than the non-magnesium group. The concentration ratio of serum calcium to magnesium was relatively unchanged postoperatively in the magnesium group, whereas it decreased significantly from the second to seventh postoperative days in the non-magnesium group. Magnesium and calcium contents in the atrial muscle were measured before and after cardiopulmonary bypass. Before bypass, magnesium and calcium contents were higher in the magnesium group than the non-magnesium group. However, in the non-magnesium group the calcium content increased significantly after bypass compared to pre-bypass levels, whereas it was unchanged in the magnesium group. Ventricular arrhythmias severer than grade 3 were found in 4 cases in the non-magnesium group. On the other hand, no ventricular arrhythmias severer than grade 3 were found in the magnesium group. As to the incidence of supraventricular arrhythmias, no difference was demonstrated between both groups. The appearance of late ventricular potentials on signal averaged electrocardiograms was found variable and often transient, and no association was found between the appearance of late ventricular potentials and the incidence of ventricular arrhythmias. Smaller fluctuations of magnesium and calcium concentrations in serum as well as in the atrial muscle were observed in the postoperative days in the magnesium group. Magnesium and calcium ratio also showed smaller fluctuations in the postoperative days in the magnesium group. In conclusion, these factors, along with suppression of calcium influx in the cardiac muscle, appeared to serve to reduce the incidence of ventricular arrhythmias in the magnesium group.
Ichikawa
S
S
Department of Cardiovascular Surgery, Tokyo Women's Medical College Daini Hospital, Japan.
D000284:Administration, Oral; D001145:Arrhythmias, Cardiac / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D005260:Female; D006325:Heart Atria / Q000378:metabolism*; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D008274:Magnesium; D002118:Calcium