Increased cell killing and mutagenecity by DNA alkylating agents in cells with decreased TTP pools.
Kubota
M
M
Department of Pediatrics, Kyoto University, Japan.
Wakazono
Y
Y
Furusho
K
K
D000477:Alkylating Agents / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005020:Ethyl Methanesulfonate / Q000633:toxicity*; D018922:HL-60 Cells / Q000187:drug effects*; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000096:biosynthesis / Q000235:genetics; D007700:Kinetics; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*; D011799:Quinazolines / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors; D013942:Thymine Nucleotides / Q000378:metabolism*
D000477:Alkylating Agents; D004791:Enzyme Inhibitors; D009153:Mutagens; D011799:Quinazolines; D013876:Thiophenes; D013942:Thymine Nucleotides; D008769:Methylnitronitrosoguanidine; D005020:Ethyl Methanesulfonate; D013940:Thymidylate Synthase; D007041:Hypoxanthine Phosphoribosyltransferase; C068874:raltitrexed; C024157:thymidine 5'-triphosphate