title: [Response to prophylactic treatment of benign headache in children].
abstract: BACKGROUND
  Common childhood headaches seldom require prophylactic treatment which, nevertheless, is quite often unsatisfactory.
  
  
  OBJECTIVE
  To study drug and non-drug related factors that may influence the therapeutic response.
  
  
  METHODS
  A four-month follow-up study of all patients attended during a year at the neuropediatric, outpatient hospital-based clinic, with > or = 2 monthly migraine without aura attacks, > or = 10 tension-type headaches, or both types of headaches. Patients were randomized to be treated on an open basis, placebo controlled, with flunarizine or piracetam. Headache frequency was evaluated according to treatment and patients' basal characteristics.
  
  
  RESULTS
  98 patients studied (56 migraine without aura, 24 tension-type headache, 18 mixed). 33% dropped out; they were school underachievers more frequently than those that completed the protocol. Of those completing the protocol and treated with placebo as the first choice of therapy, 27% reported total remission of symptomatology; those not remitting with placebo were high achievers at school significatively more frequently. At the end of the trial, 43% of the initially randomized patients still complained of headaches, regardless of treatment, showing a seasonal relationship.
  
  
  CONCLUSIONS
  Prophylaxis of benign childhood headaches is needed in less than half of those reporting a high headache frequency; school achievement should be taken into consideration as another clue to compliance and headache persistence. On a short-term basis only the seasonal influence and the placebo effect can be held responsible for amelioration of symptomatology.
authors.affiliation: Departamento de Pediatría, Hospital de Cruces, Barakaldo, Vizcaya, España.
authors.forename: C
authors.initials: C
authors.lastname: Garaizar
authors.forename: J M
authors.initials: JM
authors.lastname: Prats
authors.forename: E
authors.initials: E
authors.lastname: Zuazo
mesh_terms: D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005444:Flunarizine / Q000627:therapeutic use*; D006261:Headache / Q000188:drug therapy*; D006801:Humans; D008297:Male; D018697:Nootropic Agents / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D002121:Calcium Channel Blockers; D018697:Nootropic Agents; D005444:Flunarizine; D010889:Piracetam
vernacular_title: Respuesta al tratamiento profiláctico de las cefaleas infantiles benignas.