title: [Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System].
abstract: OBJECTIVE
  To clarify if there is any basis for the hypothesis that Clebopride leads to more extrapyramidal reactions than Metoclopramide.
  
  
  METHODS
  Observational, longitudinal, retrospective and comparative study of two series of cases.
  
  
  METHODS
  The entire Spanish healthcare system.
  
  
  METHODS
  Those notified to the Spanish Drug watch system as possibly having suffered an adverse reaction to Metoclopramide (n = 98) or Clebopride (n = 123) between 1/1/1990 and 10/6/1997.
  
  
  METHODS
  None.
  
  
  RESULTS
  84.3% of suspected adverse reactions to Clebopride and 51.6% of those to Metoclopramide had a non-hospital precedence (P < 0.001). In 48.0% of suspected adverse reactions to Metoclopramide and 72.4% of those to Clebopride, there was extrapyramidal toxicity (P = 0.021).
  
  
  CONCLUSIONS
  There is a basis for the hypothesis that Clebopride causes more extrapyramidal reactions than Metoclopramide. It was reasonable to realize a study based on this hypothesis.
authors.affiliation: Unidad de Farmacología Clínica, Hospital Virgen de la Salud de Toledo.
authors.forename: R
authors.initials: R
authors.lastname: Cuena Boy
authors.forename: M A
authors.initials: MA
authors.lastname: Maciá Martínez
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000009:adverse effects*; D001549:Benzamides / Q000009:adverse effects*; D002648:Child; D003627:Data Interpretation, Statistical; D018492:Dopamine Antagonists / Q000009:adverse effects*; D005116:Extrapyramidal Tracts / Q000187:drug effects*; D006801:Humans; D008137:Longitudinal Studies; D008787:Metoclopramide / Q000009:adverse effects*; D008875:Middle Aged; D016017:Odds Ratio; D011358:Product Surveillance, Postmarketing; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain
chemical_list: D000932:Antiemetics; D001549:Benzamides; D018492:Dopamine Antagonists; C014417:clebopride; D008787:Metoclopramide
vernacular_title: Toxicidad extrapiramidal a metoclopramida y a cleboprida: estudio de las notificaciones voluntarias de reacciones adversas al Sistema Español de Farmacovigilancia.