[Therapeutic effect of amigluracil aerosol inhalation on radiation- and bleomycin-induced pulmonitis in patients with malignant lymphomas].
The report deals with the first experience of successful administration of soluble amigluracil, a synthesized pyrimidine derivative of methyluracil, which was inhaled with aerosols to treat acute, chronic radiation-related and bleomycin-induced pulmonitis. No side-effects, including allergy, were observed.
Gershanovich
M L
ML
Prof. N. N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Filatova
L V
LV
D000280:Administration, Inhalation; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D016896:Treatment Outcome; D014498:Uracil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C014314:amigluracil; D014498:Uracil
Lechebnyĭ èffekt aèrozol'nykh ingaliatsiĭ amigluratsila pri luchevom i toksicheskom pul'monite, vyzvannom belomitsinom u bol'nykh zlokachestvennymi limfomami.