Achievement of complete cytogenetic remission after two very low-dose donor leucocyte infusions in a patient with extensive cGVHD relapsing in accelerated phase post allogeneic BMT for CML.
We report the case of a 55-year-old female who despite having developed extensive chronic graft-versus-host disease (GVHD), relapsed 35 months after a T cell-replete sibling donor bone marrow transplant for Philadelphia-positive chronic myeloid leukaemia (Ph CML). She achieved complete cytogenetic remission after discontinuation of cyclosporin A and administration of two low-dose donor leucocyte infusions (DLI 1 x 10(6) and 5 x 10(6) CD3+ cells/kg). Eighteen months after the first infusion she remains well and in complete cytogenetic remission with a normocellular marrow and no exacerbation of GVHD.
Rahman
S L
SL
Bone Marrow Transplant Unit, Addenbrooke's NHS Trust, Cambridge, UK.
Mahendra
P
P
Nacheva
E
E
Sinclair
P
P
Arno
J
J
Marcus
R E
RE
D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D003582:Cytogenetics; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000628:therapy*; D017708:Leukocyte Transfusion; D008875:Middle Aged; D012008:Recurrence; D014019:Tissue Donors; D014184:Transplantation, Homologous