Adult granulosa cell tumor of the ovary: a clinico pathologic study of 35 cases.
OBJECTIVE
Adult granulosa cell tumor has a low malignant potential but requires an extensive follow-up of more than 5 years to accurately assess tumor activity. The aim of the present study was to evaluate the clinical characteristics, the treatment and the outcome of this rare ovarian tumor.


METHODS
A retrospective review of 35 cases treated at primary onset of disease during a 23-year period from 1971 to 1993.


RESULTS
The disease-free survival rate for stages IA-B-C at 5 and 10 years was 90% and 84%, respectively; for stages III-IV the 5-year freedom from progression rate was 16%.


CONCLUSIONS
The most important prognostic factor appears to be the extent of tumor involvement outside of the ovary.
Fontanelli
R
R
Division of Gynecologic Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Stefanon
B
B
Raspagliesi
F
F
Kenda
R
R
Tomasic
G
G
Spatti
G
G
Riboldi
G
G
Di Donato
P
P
Pilotti
S
S
De Palo
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome