title: Different transfers of N-acetyl-p-aminobenzoic acid and p-aminobenzoic acid across the placenta and the small intestine in rats.
abstract: The aim of the present study was to evaluate the transfer of N-acetyl-p-aminobenzoic acid (AcPABA) across the rat term placenta and the rat small intestine and to compare it with that of its parent drug p-aminobenzoic acid (PABA). Umbilical perfusion of the rat term placenta was used to determine the materno-fetal transfer. AcPABA appeared in the fetal compartment significantly more slowly than PABA (k transfer = 0.023 and 0.064 min(-1), respectively). The rate of equilibration between the maternal and fetal compartments was slightly lower for AcPABA than for the parent drug (k eqilibration = 0.0082 and 0.011 min(-1), respectively). Similarly, AcPABA was shown to be absorbed from the small intestine significantly more slowly than PABA (ka = 0.052 and 0.82 min(-); tmax = 37 and 3.1 min, respectively). Our results showed that both investigated compounds which are structurally related and very similar in their physical-chemical characteristics crossed both the placental and small intestinal barrier with a different kinetics. AcPABA was transported across both barriers significantly more slowly than its parent compound, which might indicate a possible equipment of the placenta with a carrier for PABA, a similar one to that previously found in the rat small intestine.
authors.affiliation: Department of Pharmacology and Toxicology, Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic.
authors.forename: F
authors.initials: F
authors.lastname: Staud
authors.forename: Z
authors.initials: Z
authors.lastname: Fendrich
authors.forename: J
authors.initials: J
authors.lastname: Hartl
authors.forename: O
authors.initials: O
authors.lastname: Jindrova
authors.forename: M
authors.initials: M
authors.lastname: Láznícek
mesh_terms: D010129:4-Aminobenzoic Acid / Q000493:pharmacokinetics*; D000818:Animals; D005260:Female; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D062366:para-Aminobenzoates
chemical_list: D062366:para-Aminobenzoates; C023730:Acedoben; D010129:4-Aminobenzoic Acid