title: Low sodium diet and pregnancy-induced hypertension: a multi-centre randomised controlled trial.
abstract: OBJECTIVE
  To examine the effectiveness of the standard policy in the Netherlands to prescribe a sodium restricted diet to prevent or to treat mild pregnancy-induced hypertension.
  
  
  METHODS
  Multi-centre randomised controlled trial between April 1992 and April 1994.
  
  
  METHODS
  Seven practices of independent midwives and one university hospital.
  
  
  METHODS
  The experimental group comprised 184 women given a low sodium diet (< or = 50 mmol sodium/day) and a control group of 177 women given a normal diet. Eligible women for inclusion had had a rise of blood pressure, or excessive weight gain or oedema during the antenatal period. The 361 women in the trial were recruited from 2020 nulliparae, of whom 1512 (75%) gave informed consent at the beginning of their pregnancy to participate in the study.
  
  
  METHODS
  The difference between highest diastolic blood pressure after randomisation and diastolic blood pressure at the moment of randomisation; referral and admission to hospital for hypertension.
  
  
  RESULTS
  There was no difference in increase of diastolic blood pressure after randomisation, the percentage of referral and admission to hospital for hypertension, or in obstetric outcome between the two groups. Urinary sodium excretion after randomisation in the normal diet group was significantly higher than in the low sodium group.
  
  
  CONCLUSIONS
  Prescribing a sodium-restricted diet to prevent or to treat mild pregnancy-induced hypertension is not effective. Therefore there is no need to introduce a salt restricted diet in prenatal care, although increasing evidence shows that a low sodium diet prevents hypertension in non-pregnant individuals.
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Knuist
authors.forename: G J
authors.initials: GJ
authors.lastname: Bonsel
authors.forename: H A
authors.initials: HA
authors.lastname: Zondervan
authors.forename: P E
authors.initials: PE
authors.lastname: Treffers
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000517:prevention & control; D010298:Parity; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000178:diet therapy* / Q000517:prevention & control / Q000652:urine; D011256:Pregnancy Outcome; D012307:Risk Factors; D012964:Sodium / Q000652:urine
chemical_list: D012964:Sodium