Increased serum and mRNA levels of RANTES associated with elevated levels of activated CD8+CD38+ T cells in HIV-1 infected individuals.
The serum levels of the beta-chemokine RANTES and, albeit less, MIP-1 beta were found to be increased in 37 HIV-1 infected compared to seronegative individuals. In contrast the serum levels of IL-16 were only sporadically elevated in seropositives as well as in seronegatives. Concomitantly, the RANTES gene expression increased about tenfold in seropositives, whereas the MIP-1 beta and IL-16 mRNA levels were not elevated. No correlation between the increase of the MIP-1 beta and RANTES serum concentrations and the plasma virus load, the number of the peripheral CD4+ T cells or the therapy status of the patients was found. However, the increased proportion of activated CD8+CD38+ T cells in the peripheral blood of all seropositives paralleled the increased RANTES serum levels detected indicating that immune activation in HIV-1-infected individuals may contribute to increased RANTES serum levels.
Müller
P
P
Department of Medical Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.
Engelstädter
M
M
Werner
A
A
Braner
J
J
Staszewski
S
S
Miller
V
V
Doerr
H W
HW
Kurth
R
R
Cichutek
K
K
D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000097:blood* / Q000235:genetics; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D019410:Interleukin-16 / Q000097:blood / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D019402:Macrophage Inflammatory Proteins / Q000097:blood / Q000235:genetics; D008562:Membrane Glycoproteins; D009244:NAD+ Nucleosidase / Q000276:immunology; D012333:RNA, Messenger; D013601:T-Lymphocytes / Q000276:immunology*; D019562:Viral Load
D019380:Anti-HIV Agents; D015703:Antigens, CD; D000943:Antigens, Differentiation; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D019410:Interleukin-16; D019402:Macrophage Inflammatory Proteins; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D009244:NAD+ Nucleosidase; D051997:ADP-ribosyl Cyclase 1