Genetic and immunological host factors associated with susceptibility to HIV-1 infection.
The probability of HIV transmission depends on the interplay of many different factors related to infectiousness of the HIV-infected partner, susceptibility of the HIV-uninfected partner, and biological characteristics of HIV strains. Here, we review recent studies of host immunological and genetic factors which may affect susceptibility to HIV-1 infection. These factors are summarized in Table 1. We propose how to explore biological correlates of susceptibility to HIV-1 infection in epidemiological studies, discuss the strengths and limitations of this research, and address the implications for public health.
Buchacz
K A
KA
Department of Epidemiology, University of California, Berkeley, USA.
Wilkinson
D A
DA
Krowka
J F
JF
Koup
R A
RA
Padian
N S
NS
D004198:Disease Susceptibility; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D019707:Receptors, Chemokine; D011991:Receptors, Virus; D012307:Risk Factors
D019707:Receptors, Chemokine; D011991:Receptors, Virus