title: Focalized external radiotherapy for resected solitary brain metastasis: does the dogma stand?
abstract: OBJECTIVE
  To investigate whether whole brain irradiation might be replaced by focalized irradiation after resection of a single brain metastasis in patients where extracranial tumor control is deemed to be obtained.
  
  
  METHODS
  Twelve patients were introduced in a phase I/II prospective study of conformal postoperative external irradiation after resection of a solitary brain metastasis. The radiation treatment consisted of 50.4 Gy (1.8 Gy per fraction, five fractions per week). The planning target volume consisted of the tumor bed and a 2 cm safety margin. All treatments were optimized with head immobilization, dedicated tomodensitometry and computer assisted three-dimensional treatment planning.
  
  
  RESULTS
  The median survival was 7.2 months (range 2.4-50.4 months). Eleven of the 12 patients died. Eight of the 12 patients presented intracranial recurrence and seven died as a consequence of intracranial tumor progression.
  
  
  CONCLUSIONS
  Focalized external irradiation cannot serve as a reasonable alternative to whole brain radiotherapy (WBRT) even for patients with apparently one single resected brain metastasis. The dogma of 'one metastasis = multiple metastases' seems to be confirmed.
authors.affiliation: Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Bugnon, Lausanne, Switzerland.
authors.forename: P A
authors.initials: PA
authors.lastname: Coucke
authors.forename: A
authors.initials: A
authors.lastname: Zouhair
authors.forename: M
authors.initials: M
authors.lastname: Ozsahin
authors.forename: N
authors.initials: N
authors.lastname: De Tribolet
authors.forename: R O
authors.initials: RO
authors.lastname: Mirimanoff
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D015996:Survival Rate; D016896:Treatment Outcome