title: Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy.
abstract: Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.
authors.affiliation: Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pérez
authors.forename: J M
authors.initials: JM
authors.lastname: Valpuesta
authors.forename: E M
authors.initials: EM
authors.lastname: de Garcini
authors.forename: C
authors.initials: C
authors.lastname: Quintana
authors.forename: M
authors.initials: M
authors.lastname: Arrasate
authors.forename: J L
authors.initials: JL
authors.lastname: López Carrascosa
authors.forename: A
authors.initials: A
authors.lastname: Rábano
authors.forename: J
authors.initials: J
authors.lastname: García de Yébenes
authors.forename: J
authors.initials: J
authors.lastname: Avila
mesh_terms: D001921:Brain / Q000378:metabolism; D002421:Caudate Nucleus / Q000378:metabolism; D002847:Chromatography, Agarose; D004577:Electron Probe Microanalysis; D005293:Ferritins / Q000032:analysis* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron; D013494:Supranuclear Palsy, Progressive / Q000378:metabolism / Q000473:pathology*; D016875:tau Proteins / Q000032:analysis* / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D016875:tau Proteins; D005293:Ferritins