[Activity of renin-angiotensin-aldosterone system (RAAS) and vasopressin level in patients with primary pulmonary hypertension].
OBJECTIVE
Assessment of RAAS and vasopressin in patients with primary pulmonary hypertension (PPH).


METHODS
Activity of plasma renin (APR), angiotensin-converting enzyme (ACE), plasma levels of angiotensin II (AII) and vasopressin (VP), serum concentration of aldosteron (AS) were measured by radioimmunoassay and enzyme immunoassay in 21 PPH patients with circulatory failure (age 34.7 +/- 2.1 years), 11 patients with NYHA functional class II-III, 10 with class IV, and 10 control subjects (age 29.8 +/- 1.5 years).


RESULTS
Compared to controls, 21 PPH patients had elevated RAAS parameters: APR up to 3.52 ng/ml/h (p < 0.05), activity of ACE up to 43.13 units, AII level up to 33.93 ng/ml (p < 0.01), AS up to 468.86 ng/ml (p < 0.01), VP up to 5.26 ng/ml (p < 0.001). Circulatory failure progression resulted in activation of all the RAAS components. This and VP activation was the greatest in PPH patients with ACE > 5 ng/ml/h. PPH patients with mean pressure in the pulmonary artery higher than 60 mm Hg demonstrated higher ARP, AS, VP, AII, ACE than those who had this pressure under 60 mm Hg.


CONCLUSIONS
PPH patients display a noticeable activation of RAAS and VP. This activation seems to be secondary as the changes increase with elevation of the pressure in the pulmonary artery and aggravation of circulatory insufficiency. Plasma renin activity determines the degree of RAAS activation as a whole. The discovered activation of RAAS in PPH gives grounds for doubts in the validity of using ACE inhibitors in the treatment of PPH.
Martyniuk
T V
TV
Chazova
I E
IE
Masenko
V P
VP
Volkov
V N
VN
Belenkov
Iu N
IuN
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000503:physiopathology; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011669:Pulmonary Wedge Pressure; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology*; D014667:Vasopressins / Q000097:blood*
D015415:Biomarkers; D014667:Vasopressins; D000804:Angiotensin II; D000450:Aldosterone; D007703:Peptidyl-Dipeptidase A; D012083:Renin
Aktivnost' renin-angiotenzin-al'dosteronovoĭ sistemy i uroven' vazopressina u patsientov s pervichnoĭ legochnoĭ gipertonieĭ.