Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome: results of a case-control study.
Polycystic ovary syndrome (PCOS), a disorder of hyperandrogenism and chronic anovulation affects 5%-10% of all women. Women with PCOS often have elevated cardiovascular risk factors. A total of 244 PCOS cases were identified through the Division of Reproductive Endocrinology at Magee-Womens Hospital and were age-matched to 244 neighborhood controls. The average age of cases and controls was 35.3 +/- 7.4 and 36.7 +/- 7.7. Women with PCOS compared to controls had substantially higher LDL-C and total cholesterol levels at each age group under 45 years after adjustment for body mass index, hormone use, and insulin levels. In the over 40-year age group, little difference was noted between cases and controls. Among cases and controls (<40), PCOS predicted LDL-C, total cholesterol and triglycerides, but did not have a significant effect on lipid levels in older cases and controls after controlling for the other variables. The primarily pre- to perimenopausal PCOS cases > or =40 years of age have similar LDL-C and total cholesterol levels as their age-matched controls, probably reflecting the LDL-C increase with age among controls.
Talbott
E
E
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA.
Clerici
A
A
Berga
S L
SL
Kuller
L
L
Guzick
D
D
Detre
K
K
Daniels
T
T
Engberg
R A
RA
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D016555:Matched-Pair Analysis; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D018709:Statistics, Nonparametric
D008078:Cholesterol, LDL; D008055:Lipids