title: Multiple agminate Spitz naevi.
abstract: We report two patients with multiple agminate Spitz naevi (MASM), a rare disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described on the right shoulder, arm and hand. The melanoma risk in MASM is also discussed.
authors.affiliation: Department of Dermatology, University Hospital Leiden, The Netherlands.
authors.forename: M M
authors.initials: MM
authors.lastname: Hulshof
authors.forename: A
authors.initials: A
authors.lastname: van Haeringen
authors.forename: N A
authors.initials: NA
authors.lastname: Gruis
authors.forename: D C
authors.initials: DC
authors.lastname: Snels
authors.forename: W
authors.initials: W
authors.lastname: Bergman
mesh_terms: D000293:Adolescent; D001132:Arm; D001706:Biopsy; D002675:Child, Preschool; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006225:Hand; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology; D018332:Nevus, Epithelioid and Spindle Cell / Q000235:genetics* / Q000473:pathology*; D012306:Risk; D012782:Shoulder; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology*; D014178:Translocation, Genetic