title: Pyridoxine-responsive PH1: treatment.
abstract: Owing to the rarity of PH, the efficacy of pyridoxine therapy has only been tested in very small series of patients. From two recent reports including 18 patients, 50% of patients would be unresponsive to pyridoxine whereas oxaluria would be normalized in 20% of patients and somewhat reduced-but not to normal level-in the remaining 30%. In a few aneodotical cases pyridoxine administration was reported to improve kidney function in patients with renal failure secondary to hyperoxaluria. It is reminded that megadoses of pyridoxine (0.5 to 6 g daily) may induce severe sensory neuropathy.
authors.affiliation: Département médico-chirurgical de Néphrologie, Cliniques Universitaires de Bruxelles, Hôpital Erasme, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Toussaint
mesh_terms: D005260:Female; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000517:prevention & control; D008297:Male; D011736:Pyridoxine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D011736:Pyridoxine