Inhibitory effect of bacterial attachment on candidal growth due to adherence with mannose-sensitive pili.
A bacterial strain with affinity to Candida albicans was successfully obtained from a natural environment. An uncovered Petri dish containing a suspension of heat-killed C. albicans cells was allowed to stand in a laboratory for several days. Some bacteria which had adhered to the candidal cells were tested for their ability to agglutinate the cells. A bacterial strain, designated later as CAB-1, was found to agglutinate candidal cells through bridging by mannose-sensitive pili. CAB-1 showed similar bacteriological characteristics to those of Citrobacter freundii by ID test. The adherence of CAB-1 to candidal cell was precisely presented by scanning electron microscopy. The inhibitory effect of CAB-1 attachment to candidal cells on the growth of Candida was also preliminarily confirmed.
Seki
K
K
Department of Microbiology, The Jikei University School of Medicine, Tokyo, Japan.
Kobayashi
K
K
Tomiya
Y
Y
Sakurada
J
J
Murai
M
M
Usui
A
A
Masuda
S
S
D000371:Agglutination; D000898:Antibiosis; D001422:Bacterial Adhesion; D002176:Candida albicans / Q000254:growth & development* / Q000302:isolation & purification / Q000648:ultrastructure; D002954:Citrobacter / Q000502:physiology; D010861:Fimbriae, Bacterial / Q000502:physiology*; D006090:Gram-Negative Bacteria / Q000302:isolation & purification / Q000502:physiology* / Q000648:ultrastructure; D008358:Mannose / Q000494:pharmacology; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning
D008358:Mannose