Dose-dependent valproic acid thrombocytopenia in bipolar disorder.
The increased use of anticonvulsants in the treatment of bipolar disorders necessitates a greater appreciation of potential complications from these agents. The authors present a bipolar disorder patient with dose-dependent valproic acid thrombocytopenia and suggest treatment strategies.
Kaufman
K R
KR
Department of Psychiatry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08901, USA.
Gerner
R
R
D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D018692:Antimanic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced*; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects*
D000927:Anticonvulsants; D018692:Antimanic Agents; D014635:Valproic Acid