title: Secoiridoid glycosides and an antifungal anthranilate derivative from Gentiana tibetica.
abstract: Repetitive chromatography of the methanol extract of the roots of Gentiana tibetica afforded two new secoiridoid glycosides and a novel antifungal anthranilic acid derivative, together with beta-sitosterol, daucosterol, oleanolic acid, loganic acid, gentiopicroside, sweroside, 2'-(2,3-dihydroxybenzoyl)sweroside, trifloroside, rindoside and macrophylloside A. The structures of the new products were determined mainly by spectroscopic methods as 8-hydroxy-10-hydrosweroside, isomacrophylloside and ethyl N-docosanoylanthranilate. Ethyl N-docosanoylanthranilate inhibited the growth of the human pathogenic fungi Candida albicans and Aspergillus flavus. The taxonomic significance of the constituent is discussed briefly.
authors.affiliation: Department of Biological Science & Technology, Nanjing University, P.R. China.
authors.forename: R X
authors.initials: RX
authors.lastname: Tan
authors.forename: L D
authors.initials: LD
authors.lastname: Kong
authors.forename: H X
authors.initials: HX
authors.lastname: Wei
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002236:Carbohydrate Conformation; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D057888:Iridoid Glucosides; D039823:Iridoids; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C112673:10-hydro-8-hydroxysweroside; D000935:Antifungal Agents; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D011714:Pyrans; C112674:ethyl N-docosanoylanthranilate; C112675:isomacrophylloside; D062367:ortho-Aminobenzoates