title: Positive result by serology indicates active Helicobacter pylori infection in patients with atrophic gastritis.
abstract: Patients with atrophic corpus gastritis and elevated Helicobacter pylori antibody titers but 13C-urea breath test (13C-UBT) and histology results negative for H. pylori were randomized into eradication therapy or follow-up only. Antibody levels decreased significantly in six out of seven patients in the eradication group, while in the follow-up group, the titers declined in only one out of eight patients. In patients with atrophic corpus gastritis, positive serology results may indicate an ongoing infection in spite of negative 13C-UBT and histology results.
authors.affiliation: Second Department of Surgery, Helsinki University Central Hospital, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Kokkola
authors.forename: H
authors.initials: H
authors.lastname: Rautelin
authors.forename: P
authors.initials: P
authors.lastname: Puolakkainen
authors.forename: P
authors.initials: P
authors.lastname: Sipponen
authors.forename: M
authors.initials: M
authors.lastname: Färkkilä
authors.forename: R
authors.initials: R
authors.lastname: Haapiainen
authors.forename: T U
authors.initials: TU
authors.lastname: Kosunen
mesh_terms: D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood*; D001944:Breath Tests; D004359:Drug Therapy, Combination; D005757:Gastritis, Atrophic / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D014508:Urea / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D000658:Amoxicillin; D014508:Urea