[Prognostic value of E-cadherin expression in hepatocellular carcinoma].
Expression of E-cadherin (E-cad) was investigated immunohistologically in 91 cases of operated hepatocellular carcinomas. An alteration of E-cad immunodetection was found in 56% of tumours. These alterations were correlated with histopathologic features of prognostic value including tumour size (> 3 cm), high nuclear grade and mitotic index. Patients with down-regulated E-cad expression had statistically significant shorter survival than the others. Although E-cad immunodetection was an independent prognostic factor, the Cox multivariate analysis showed that its prognostic value was low when compared to other prognostic factors.
Garcia
S
S
Service d'Anatomie et Cytologie Pathologiques, Faculté de médecine, Marseille.
Martini
F
F
De Micco
C
C
Andrac
L
L
Sappa
P
P
Hardwigsen
J
J
Lavaut
M N
MN
Le Treut
Y P
YP
Charpin
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000096:biosynthesis*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
D015820:Cadherins
Valeur pronostique de l'expression de l'E-cadhérine dans les hépatocarcinomes.