A case of primary splenic large cell lymphoma with a t(9;14)(p13;q32).
t(9;14)(p13;q32), a subtype of 14q32 translocation, plays an essential role in the development of lymphoplasmacytoid lymphoma. t(9;14)(p13;q32) Causes juxtaposition of the PAX-5 gene on 9p13 and the IgH gene on 14q32, leading to the deregulation of the PAX-5 gene. We report a case of primary splenic lymphoma with a t(9;14). The histological diagnosis was diffuse large B-cell lymphoma without plasmacytoid differentiation. The lymphoma cells showed a complex karyotype including a t(9;14). Southern blot analysis localized the breakpoint of the PAX-5 gene within a couple of kb regions upstream of the exon 1A, although the involvement of the PAX-5 gene with the immunoglobulin heavy chain gene could not be confirmed.
Kawakami
K
K
Division of Hematology, Tenri Hospital, Nara, Japan.
Amakawa
R
R
Miyanishi
S
S
Okumura
A
A
Hayashi
T
T
Kurata
M
M
Ohno
H
H
Ohno
Y
Y
Fukuhara
S
S
D002883:Chromosomes, Human, Pair 14; D002899:Chromosomes, Human, Pair 9; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D014178:Translocation, Genetic
D004247:DNA