[Apoptosis: current status of the problem].
Accelerating progress in studying the nature of apoptosis (programmed cell death, PCD) has been observed in recent years. Apoptosis proved to be preprogrammed biological phenomenon with the key role in fundamental processes such as embryogenesis, morphogenesis, and cellular homeostasis. Apoptosis is induced by specific physiological signals as well as by various damaging influences. A complex system of metabolic and genetic control of apoptosis is realized by phylogenetically conserved set of genes with pro- and antiapoptotic activity. Genetic and metabolic disturbances of initiation and/or realization of PCD make substantial contribution to a number of pathologies such as cancer, AIDS, and degenerative processes. Active search for apoptosis-controlling remedies may open new horizons for fighting these widespread diseases.
Khanson
K P
KP
Petrov Institute of Oncology, Department of Health of Russian Federation, St. Petersburg, Russia.
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D002118:Calcium / Q000502:physiology; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D019014:fas Receptor / Q000502:physiology
D002843:Chromatin; D011518:Proto-Oncogene Proteins; D019014:fas Receptor; D002118:Calcium
Apoptoz: sovremennoe sostoianie problemy.