The role of chemokines in tissue inflammation and autoimmunity in renal diseases.
Chemokines are an expanding family of chemoattractant polypeptides involved in the extravasation of leukocytes during the inflammatory process. This review highlights recent advances in the field, including the discovery of a new class of chemokines, and several novel receptors. In addition, the expanding role of chemokines in pathologic processes other than extravasation and their potential as therapeutic targets are discussed.
Lloyd
C
C
Inflammation Division, Millennium Pharmaceuticals Inc., Cambridge, Massachusetts, USA.
Gutierrez-Ramos
J C
JC
D000818:Animals; D015551:Autoimmunity; D018925:Chemokines / Q000145:classification / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D009393:Nephritis / Q000209:etiology; D019707:Receptors, Chemokine / Q000502:physiology
D018925:Chemokines; D018836:Inflammation Mediators; D019707:Receptors, Chemokine