Detection of serum p53 antibodies in patients with esophageal squamous cell carcinoma: correlation with clinicopathologic features and tumor markers.
The significance of serum p53-Abs in patients with esophageal squamous cell carcinoma was determined. Examination of clinicopathological features and assessment of tumor marker sensitivities of carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC-Ag) and CYFRA21-1 were performed. Thirty-three (58%) of 57 patients were positive for serum p53-Abs, however, no relation with cancer progression existed. Fourteen of the 33 sero-positive patients revealed normal levels of all tumor markers tested. Thus, serum p53-Abs appears to be a useful marker for the detection of esophageal squamous cell carcinoma.
Shimada
H
H
Department of Surgery, School of Medicine, Chiba University, Chuou-ku, Chiba 260-8670, Japan.
Nakajima
K
K
Ochiai
T
T
Koide
Y
Y
Okazumi
S I
SI
Matsubara
H
H
Takeda
A
A
Miyazawa
Y
Y
Arima
M
M
Isono
K
K
D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000097:blood*; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D016158:Genes, p53; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012680:Sensitivity and Specificity; D015843:Serpins; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
D000906:Antibodies; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D015843:Serpins; D016159:Tumor Suppressor Protein p53; C051072:squamous cell carcinoma-related antigen