[Physico-chemical bases of the mechanism of thermal inactivation of the foot-and-mouth disease virus].
Experiments demonstrated that the effect of water activity on the solvate complex of virions underlies the mechanism of thermal inactivation of the foot and mouth disease virus in suspension; changes in the structure of the complex impair the electrophysical balance of the RNA-protein relations and hence, destroy the virus. Heating of virus-containing suspensions at moderate positive temperatures leads to destruction of the noninfectious part of virus population of 146S particles, thus decreasing the infectious activity of the virus.
Ponomarev
A P
AP
Andreeva
O G
OG
D005537:Aphthovirus / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D006358:Hot Temperature; D012367:RNA, Viral / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism; D014771:Virion / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity
D012367:RNA, Viral; D016601:RNA-Binding Proteins; D014764:Viral Proteins
Fiziko-khimicheskie osnovy mekhanizma termoinaktivatsii virusa iashchura.