Antiatherosclerotic potency of high density lipoprotein of different origins: a review and some new findings.
The antiatherosclerotic potency of isolated high density lipoproteins (HDL) of different origins was investigated in three experimental models: (1) isolated HDL were injected into cholesterol-rich fed rabbits; (2) the effect of HDL on the intracellular level of free and esterified cholesterol as well as on proliferation of smooth muscle cells and fibroblasts was investigated in cell cultures; and (3) we studied the influence of isolated HDL fractions on thromboxane (TXB2) formation in clotting whole blood with different cholesterol content.
Beitz
A
A
Martin Luther University Halle-Wittenberg, School of Medicine, Halle, Germany.
Beitz
J
J
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000188:drug therapy / Q000517:prevention & control*; D002478:Cells, Cultured; D004195:Disease Models, Animal; D006801:Humans; D008075:Lipoproteins, HDL / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000924:Anticholesteremic Agents; D008075:Lipoproteins, HDL