title: Thrombocytopenic purpura as adverse reaction to recombinant hepatitis B vaccine.
abstract: Three cases of immune thrombocytopenic purpura after the first dose of recombinant hepatitis B vaccine occurred in infants under 6 months of age. Other possible causes of this condition were excluded. Antiplatelet antibodies were present. A defect in platelet production was excluded in two children. Corticosteroid treatment was effective. Subsequent administration of other vaccines (against polio, diphtheria, and tetanus) did not cause relapse of thrombocytopenia.
authors.affiliation: Divisione Pediatrica-Ospedale Civile di Cattolica (RN), Cattolica (RN), Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ronchi
authors.forename: P
authors.initials: P
authors.lastname: Cecchi
authors.forename: F
authors.initials: F
authors.lastname: Falcioni
authors.forename: A
authors.initials: A
authors.lastname: Marsciani
authors.forename: G
authors.initials: G
authors.lastname: Minak
authors.forename: G
authors.initials: G
authors.lastname: Muratori
authors.forename: P L
authors.initials: PL
authors.lastname: Tazzari
authors.forename: S
authors.initials: S
authors.lastname: Beverini
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology* / Q000276:immunology; D014614:Vaccines, Synthetic / Q000009:adverse effects*
chemical_list: D001323:Autoantibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic