[Cutaneous lupus erythematosus and buccal aphthosis after hepatitis B vaccination in a 6-year-old child].
BACKGROUND
Although the hepatitis B vaccination tolerance is generally good, adverse effects, which are specially neurologic and cutaneous, have been observed and some cases of induced diseases with immunological disorders have been reported.


METHODS
A 6 year-old boy presented a cutaneous lupus erythematosus and a severe buccal aphthosis following hepatitis B vaccination. There was no clinical or biological symptom of systemic lupus erythematosus nor of Behçet's disease. Under chloroquine therapy, the cutaneous manifestations of lupus erythematosus disappeared quickly and those of buccal aphthosis improved.


CONCLUSIONS
Hepatitis B vaccination side effects are probably in relation with a specific or non specific stimulation of the immune system. In our case, cellular immunity is perhaps involved through the HBs antigen. Considering the rarity of these side effects, an individual predisposition seems very likely.
Grézard
P
P
Service de Dermatologie, Hôpital de l'Hôtel-Dieu, Lyon.
Chefaï
M
M
Philippot
V
V
Perrot
H
H
Faisant
M
M
D000962:Antimalarials / Q000627:therapeutic use; D002648:Child; D002738:Chloroquine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008297:Male; D013281:Stomatitis, Aphthous / Q000209:etiology*
D000962:Antimalarials; D005938:Glucocorticoids; D017325:Hepatitis B Vaccines; D002738:Chloroquine
Lupus érythémateux cutané et aphtose buccale après vaccination contre l'hépatite B chez un enfant âgé de 6 ans.