[Selective suppression of the direct and feedback "fast" inhibition during local administration of picrotoxin in the CA1 region of rat hippocampal slices].
Application of picrotoxin to apical dendrites in the CA1 area of the rat hippocampal slices increased the duration of focal potentials (FP) in the stratum radiatum but did not affect the unit activity spikes' amplitude in the stratum pyramidalis, the finding suggesting a suppression of the feed-forward inhibition with no effect upon the recurrent one. The data obtained shows that, under conditions normally used for studying the NMDA-EPSP feed-forward, the inhibition is not invariably suppressed and may affect the results of the studies.
Baiazitov
I T
IT
Bashkir State University, Ufa, Russia.
Kleshchevnikov
A M
AM
D000818:Animals; D003712:Dendrites / Q000187:drug effects / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D005246:Feedback / Q000187:drug effects / Q000502:physiology; D018756:GABA Antagonists / Q000494:pharmacology*; D058787:GABA-A Receptor Antagonists; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D066298:In Vitro Techniques; D008274:Magnesium / Q000378:metabolism; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D010852:Picrotoxin / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology
D018756:GABA Antagonists; D058787:GABA-A Receptor Antagonists; D008274:Magnesium; D010852:Picrotoxin; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate
Selektivnoe podavlenie priamogo i vozvratnogo "bystrogo" tormozheniia pri lokal'noĭ applikatsii pikrotoksina na CA1 oblast' srezov gippokampa krysy.