title: Crohn's disease in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival.
abstract: OBJECTIVE
  Many centers worldwide have reported an increased incidence of Crohn's disease, but population-based data in North America are sparse. We studied the incidence and prevalence of Crohn's disease in Olmsted County, Minnesota, and examined temporal trends in incidence and survival.
  
  
  METHODS
  Residents diagnosed with Crohn's disease between 1970 and 1993 were incidence cases, and residents with Crohn's disease who were alive on January 1, 1991, were prevalence cases. Cases from previous studies were reconfirmed. Rates were adjusted using 1990 U.S. Census figures for whites. Incidence trends were evaluated with a Poisson regression model. Survival from diagnosis was compared with that expected for U.S. north-central whites.
  
  
  RESULTS
  Between 1940 and 1993, 225 incidence cases were identified, for an adjusted incidence rate of 5.8 per 100,000 person-years. On January 1, 1991, there were 145 residents with Crohn's disease, an adjusted prevalence rate of 133 per 100,000, 46% higher than that seen in 1980. Incidence rates before 1964 were significantly lower than those of 1989-1993. Observed survival was less than expected (P = 0.007).
  
  
  CONCLUSIONS
  The incidence of Crohn's disease has stabilized since the 1970s at a rate higher than that seen previously. Prevalence has increased by 46% since 1980. Overall survival is slightly decreased.
authors.affiliation: Inflammatory Bowel Disease Clinic, Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA. loftus.edward@mayo
authors.forename: E V
authors.initials: EV
authors.lastname: Loftus
authors.forename: M D
authors.initials: MD
authors.lastname: Silverstein
authors.forename: W J
authors.initials: WJ
authors.lastname: Sandborn
authors.forename: W J
authors.initials: WJ
authors.lastname: Tremaine
authors.forename: W S
authors.initials: WS
authors.lastname: Harmsen
authors.forename: A R
authors.initials: AR
authors.lastname: Zinsmeister
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003424:Crohn Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D015995:Prevalence; D016016:Proportional Hazards Models; D012044:Regression Analysis; D017678:Sex Distribution; D016019:Survival Analysis