title: Effect of 20 days' bed rest on the reverse cholesterol transport system in healthy young subjects.
abstract: OBJECTIVE
  To study the effects of 20 days of bed rest on HDL cholesterol, lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase.
  
  
  METHODS
  A 20-day intervention study.
  
  
  METHODS
  Makita general hospital.
  
  
  METHODS
  Five male and five female healthy participants, mean age 20.4 years, range 19-24 years.
  
  
  METHODS
  Twenty days of bed rest.
  
  
  METHODS
  Lipid, lipoprotein, lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase.
  
  
  RESULTS
  Fasting HDL, HDL2 and HDL3 cholesterol levels decreased from 1.748 to 1.404 mmol L(-1) (P < 0.01), from 0.807 to 0.628 mmol L(-1) (P < 0.01) and from 0.939 to 0.784 mmol L(-1) (P < 0.05), respectively, while VLDL triglyceride levels increased from 0.365 to 0.754 mmol L(-1) (P < 0.05). Plasma post-heparin lipoprotein lipase activity decreased from 0.494 to 0.418 micromol mL(-1) h(-1) (P < 0.01), but plasma post-heparin hepatic triglyceride lipase activity and cholesterol ester transfer protein activity did not change during bed rest. Lecithin-cholesterol acyltransferase activity increased from 72.5 to 84.8 nmol mL(-1) h(-1) (P < 0.001).
  
  
  CONCLUSIONS
  Twenty days of bed rest induced a decline in HDL cholesterol levels and an increase in VLDL triglyceride levels. When considering lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase as factors in the decreased HDL cholesterol, the contribution of lipoprotein lipase is suggested.
authors.affiliation: Aichi Prefectural College of Nursing and Health, Nagoya, Japan. ryanako@aichi-nurs.ac.jp
authors.forename: R
authors.initials: R
authors.lastname: Yanagibori
authors.forename: K
authors.initials: K
authors.lastname: Kondo
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kawakubo
authors.forename: T
authors.initials: T
authors.lastname: Iwamoto
authors.forename: H
authors.initials: H
authors.lastname: Itakura
authors.forename: A
authors.initials: A
authors.lastname: Gunji
mesh_terms: D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D001510:Bed Rest; D002352:Carrier Proteins / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006023:Glycoproteins; D006801:Humans; D008049:Lipase / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
chemical_list: D001053:Apolipoproteins; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D006023:Glycoproteins; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008049:Lipase; D008071:Lipoprotein Lipase