The effect of ketamine pretreatment on propofol injection pain in 100 women.
A controlled, randomised double-blind study was performed to compare the prior intravenous administration of ketamine 10 mg (1 ml) or 0.9% saline (1 ml) on propofol injection pain. One hundred patients of ASA status 1 or 2 presenting for gynaecological surgery were studied. Following an initial 5-ml bolus of propofol into a dorsal hand vein, 30 s after the treatment, 84% of the saline control patients experienced mild or severe pain compared to 26% of those who were given ketamine pretreatment (p < 0.05).
Tan
C H
CH
Department of Anaesthesia, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, People's Republic of China.
Onsiong
M K
MK
Kua
S W
SW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000778:Anesthetics, Dissociative / Q000627:therapeutic use*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D007649:Ketamine / Q000627:therapeutic use*; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D015742:Propofol / Q000009:adverse effects*; D011446:Prospective Studies
D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D007649:Ketamine; D015742:Propofol