title: POEMS syndrome with vascular lesions and renal carcinoma - possible role of cytokines.
abstract: We describe here the case of a 60 years man with POEMS syndrome associated with renal tumor and vascular lesions. The patient had osteosclerotic myeloma IgA-lambda, polyneuropathy, endocrinopathy and skin changes. In addition, he developed renal clear cell carcinoma and gangrena of lower limbs. The humoral study showed thrombocytosis, high levels of IL-1beta and IL-6 and of some coagulative/fibrinolytic and endothelial factors (von Willebrand factor, plasmin-antiplasmine complexes, plasminogen activator). We suggest the hypothesis that these factors are capable of determining some manifestations of POEMS syndrome.
authors.affiliation: U.O. Immunologia Clinica, Policlinico Le Scotte , I-53100 Siena, Italy. defranco@unisi.it
authors.forename: A L
authors.initials: AL
authors.lastname: Pasqui
authors.forename: G
authors.initials: G
authors.lastname: Bova
authors.forename: M
authors.initials: M
authors.lastname: Saletti
authors.forename: F
authors.initials: F
authors.lastname: Bruni
authors.forename: M
authors.initials: M
authors.lastname: Di Renzo
authors.forename: A
authors.initials: A
authors.lastname: Auteri
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000150:complications / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007680:Kidney Neoplasms / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000150:complications / Q000276:immunology*; D010960:Plasminogen Activators / Q000097:blood; D014657:Vasculitis / Q000150:complications / Q000276:immunology*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014841:von Willebrand Factor; D010960:Plasminogen Activators