title: [Mycobacterium genavense infection in 2 HIV seropositive patients in Amsterdam].
abstract: Two patients with an HIV-I infection, a man aged 47 with confusion, aphasia and diarrhoea, and a man aged 32 with dysphagia, a non-productive cough and diarrhoea, were diagnosed as having a disseminated Mycobacterium genavense infection. Both had low counts of CD4+ T lymphocytes. They responded to antimycobacterial treatment. M. genavense was recognized in Geneva in the early nineties as a causative agent of disseminated mycobacterial infections in HIV-seropositive patients with poor cellular immunity. The clinical picture resembles that of a generalized infection with M. avium-intracellulare. M. genavense is a slowly growing mycobacterium which can be isolated and identified using enriched nutrient media and molecular-biological techniques. The infection probably begins in the gastrointestinal tract after oral contamination. DNA of M. genavense can be demonstrated in 25% of the intestinal biopsy samples of non-HIV-seropositive patients.
authors.affiliation: Universiteit van Amsterdam, Academisch Medisch Centrum, Amsterdam.
authors.forename: E J
authors.initials: EJ
authors.lastname: Kuijper
authors.forename: M
authors.initials: M
authors.lastname: de Witte
authors.forename: D W
authors.initials: DW
authors.lastname: Verhagen
authors.forename: A H
authors.initials: AH
authors.lastname: Kolk
authors.forename: J T
authors.initials: JT
authors.lastname: van der Meer
authors.forename: J
authors.initials: J
authors.lastname: Dankert
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents; D018791:CD4 Lymphocyte Count; D003371:Cough / Q000209:etiology; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000209:etiology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis* / Q000188:drug therapy; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Infectie met Mycobacterium genavense bij 2 HIV-seropositieve patiënten in Amsterdam.