title: Demyelinating neuropathy in a patient with multiple sclerosis and genotypical HMSN-1.
abstract: Patients with multiple sclerosis (MS) may develop a peripheral neuropathy, sometimes attributed to nutritional deficiency. Other patients present with a demyelinating neuropathy which is presumed to be the result of an autoimmune process that affects both the central and peripheral nervous systems. We report a case of concurring MS and demyelinating neuropathy, without a positive family history, in whom genetic testing proved the neuropathy to be hereditary and not autoimmune. Hereditary neuropathy should be a consideration in sporadic cases of peripheral neuropathy and MS.
authors.affiliation: Department of Neurology, University of Tennessee Memphis 38163, USA.
authors.forename: M
authors.initials: M
authors.lastname: Almsaddi
authors.forename: T E
authors.initials: TE
authors.lastname: Bertorini
authors.forename: W K
authors.initials: WK
authors.lastname: Seltzer
mesh_terms: D000328:Adult; D002607:Charcot-Marie-Tooth Disease / Q000175:diagnosis / Q000235:genetics*; D004247:DNA / Q000032:analysis*; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000235:genetics*; D003937:Diagnosis, Differential; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000235:genetics*
chemical_list: D004247:DNA