Sensitivity of the early luteal phase ovine cervix to prostaglandin E2 (PGE2) and expression of EP3 receptor mRNA.
The effects and mechanism of action of prostaglandin E2 (PGE2) on the ovine cervix are largely unknown in the luteal phase. In these studies we have shown that low levels of EP3-receptor (EP3R) mRNA are present in the ovine cervix and that the PGE2 induces activation of polymorphonuclear leukocytes in the ovine cervix on day 6 of the oestrous cycle. It is possible, therefore, that PGE2 acts on the ovine cervix through coupling to EP3 receptors.
Audicana
L
L
Department of Veterinary Pre-clinical Sciences, University of Glasgow Veterinary School.
Aughey
E
E
O'Shaughnessy
P J
PJ
D000818:Animals; D001483:Base Sequence; D002584:Cervix Uteri / Q000187:drug effects / Q000502:physiology*; D003338:Corpus Luteum / Q000502:physiology; D018076:DNA, Complementary; D015232:Dinoprostone / Q000494:pharmacology*; D004971:Estrus; D005260:Female; D006801:Humans; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012333:RNA, Messenger / Q000096:biosynthesis; D018078:Receptors, Prostaglandin E / Q000096:biosynthesis* / Q000235:genetics*; D058308:Receptors, Prostaglandin E, EP3 Subtype; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D012756:Sheep; D014158:Transcription, Genetic
D018076:DNA, Complementary; C545647:PTGER3 protein, human; D012333:RNA, Messenger; D018078:Receptors, Prostaglandin E; D058308:Receptors, Prostaglandin E, EP3 Subtype; D015232:Dinoprostone