title: Systemic oxidative stress and cognitive performance in the population-based EVA study. Etude du Vieillissement Artériel.
abstract: The aim of this study was to examine the relationships between cognitive functioning and blood levels of antioxidants and lipoperoxidation products in an elderly population. In 1991-1992, 1389 volunteers (574 men and 815 women aged 59 to 71 years) were recruited from the general population. Levels of selenium, carotenoids, and thiobarbituric-reactive substances in plasma and of vitamin E, glutathione peroxidase, and Cu-Zn superoxide dismutase in red blood cells were measured. Cognitive functioning was assessed with various psychometric tests. We used logistic regression to estimate the risk of poor cognitive functioning (< 25th percentile of the score distribution) associated with low values of each antioxidants (< 25th percentile) including potential confounding factors. A low level of total carotenoids (< 1.86 mumol/l) was associated with poor cognitive performance in two tests assessing visual attention and logical reasoning: the Trail-Making Test part B [OR = 1.34 IC95% (0.99-1.81), p = .055] and the Digit Symbol Substitution from the WAIS-R [OR = 1.38 IC95% (1.02-1.89), p = .04]. Low levels of other antioxidants and high levels of thiobarbituric-reactive substances were not related to poor cognitive functioning. Results observed with plasma carotenoids are in accordance with previous data obtained mostly from dietary records.
authors.affiliation: INSERM U360 Recherches épidémiologiques en neurologie et psychopathologie Hôpital de la Salpêtrière, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Berr
authors.forename: M J
authors.initials: MJ
authors.lastname: Richard
authors.forename: A M
authors.initials: AM
authors.lastname: Roussel
authors.forename: C
authors.initials: C
authors.lastname: Bonithon-Kopp
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000523:psychology*; D000975:Antioxidants / Q000378:metabolism; D002338:Carotenoids / Q000097:blood; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000378:metabolism; D005260:Female; D005602:France; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012643:Selenium / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D002338:Carotenoids; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium