Importins and exportins: how to get in and out of the nucleus.
Every minute, several million protein and RNA molecules must be transported between the cytoplasm and the nucleus of a eukaryotic cell. The characterization of mediators, receptors and accessory factors for different nuclear import and export pathways has provided a glimpse at the molecular machinery that is responsible for these trafficking events. It appears that both inbound and outbound traffic is mediated by a protein family of related transport factors that can be classified as importins and exportins.
Weis
K
K
Dept of Biochemistry and Biophysics, UCSF 94143-0448, USA. kweis@itsa.ucsf.edu
D000595:Amino Acid Sequence; D001692:Biological Transport / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism*; D008969:Molecular Sequence Data; D009698:Nucleoproteins / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
D009698:Nucleoproteins; D011506:Proteins