c-Fos expression in NMDA receptor-contained neurons in spinal cord in a rat model of inflammation: a double immunocytochemical study.
Double-labeling techniques were used to demonstrate the nociceptive activation of NMDA receptor-contained neurons in spinal dorsal horn by using c-Fos immunoreactivity as an indicator of this activation in a rat model of inflammation. About 25% and 55% of the c-Fos-immunoreactive neurons that were found in laminae I-II and lamina V showed NMDA receptor immunoreactivity, while about 4% and 11% of NMDA-receptor immunoreactive neurons in these two regions showed c-Fos immunoreactivity, respectively. The implication of the results was discussed.
Zhang
R X
RX
Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Wang
H
H
Ruda
M
M
Iadarola
M J
MJ
Qiao
J T
JT
D000818:Animals; D005620:Freund's Adjuvant; D017781:Genes, Immediate-Early / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D009187:Myelitis / Q000378:metabolism*; D009474:Neurons / Q000737:chemistry / Q000378:metabolism*; D010146:Pain / Q000139:chemically induced / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis*; D013116:Spinal Cord / Q000737:chemistry / Q000166:cytology* / Q000276:immunology
D016760:Proto-Oncogene Proteins c-fos; D016194:Receptors, N-Methyl-D-Aspartate; D005620:Freund's Adjuvant