Transplantation of multipotent progenitors from the adult olfactory epithelium.
Mammalian olfactory epithelium produces new neurons rapidly throughout adulthood. Here, we demonstrate that precursor cells harvested from the adult olfactory epithelium, when transplanted into the nasal mucosa of host rats exposed previously to an olfactotoxic gas, engraft and participate in neuroepithelial reconstitution. In contrast to their normal neuronal fate in situ, grafted precursors harvested from bulbectomized donors produced non-neuronal cells as well as neurons. These results demonstrate that epithelial precursors activated following olfactory bulbectomy are not irreversibly committed to making neurons. Thus, olfactory progenitors are subject to a form of feedback control in vivo that regulates the types of cells that they produce within a broader-than-neuronal repertoire.
Goldstein
B J
BJ
Department of Anatomy and Cell Biology, SUNY Health Science Center, Syracuse 13210, USA.
Fang
H
H
Youngentob
S L
SL
Schwob
J E
JE
D000469:Alkaline Phosphatase / Q000096:biosynthesis; D000818:Animals; D002454:Cell Differentiation; D005822:Genetic Vectors; D006801:Humans; D051379:Mice; D008979:Moloney murine leukemia virus; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D009830:Olfactory Bulb / Q000502:physiology*; D009831:Olfactory Mucosa / Q000166:cytology* / Q000502:physiology / Q000637:transplantation*; D051381:Rats; D011916:Rats, Inbred F344; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D013234:Stem Cells; D014162:Transfection; D016042:Transplantation, Heterotopic; D001616:beta-Galactosidase / Q000096:biosynthesis
D011993:Recombinant Fusion Proteins; D000469:Alkaline Phosphatase; D001616:beta-Galactosidase