Simulations of protein folding and unfolding.
The 'new view' of protein folding is based on a statistical analysis of the landscape for protein folding. This perspective leads to the investigation of the statistical distributions of protein conformations as the folding protein approaches the native state from unfolded states. Molecular dynamics simulations of both the thermodynamics of protein folding and the kinetics of unfolding are beginning to explore the statistical nature of these distributions. They also provide connections between the theory of protein folding landscapes and the experimental observations of the properties of key ensembles of the conformations populated as folding progresses.
Brooks
C L
CL
Department of Biology, Scripps Research Institute, La Jolla, California 92037, USA. brooks@scripps.edu
D008956:Models, Chemical; D011489:Protein Denaturation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D012997:Solvents; D013816:Thermodynamics
D011506:Proteins; D012997:Solvents