title: [General problems in the study of the mutagenic properties of drugs].
abstract: The article deals with the results characterizing the state of Russian and foreign elaborations in the study of genotoxic effects of drugs and immunobiological agents. Particular attention is placed on general problems of strategy and tactics in the study of mutagenicity of drugs the solution of which is insufficiently substantiated or insufficiently discussed in the literature. The perspective problems of research into the field of genotoxicity of drugs are discussed.
authors.affiliation: Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: A D
authors.initials: AD
authors.lastname: Durnev
authors.forename: G M
authors.initials: GM
authors.lastname: Volgareva
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D009152:Mutagenicity Tests / Q000379:methods / Q000592:standards; D009153:Mutagens / Q000009:adverse effects* / Q000633:toxicity; D012106:Research / Q000592:standards; D012107:Research Design; D013329:Structure-Activity Relationship
chemical_list: D009153:Mutagens
vernacular_title: Obshchie voprosy izucheniia mutagennykh svoĭstv lekarstvennykh sredstv.