[Noninvasive investigation of endothelial function in patients with hypertension and hypercholesterolemia (HCE)].
OBJECTIVE
Functional assessment of endothelium by endothelium-dependent and non-endothelium dependent response of the brachial artery (BA) in patients with risk factors for atherosclerosis.


METHODS
The ACUSON 128 XP/10 unit furnished with linear meter with phase grid (7.0 MHz) was employed in two-direction scanning mode to measure BA diameter at rest, under reactive hyperemia (endothelium-dependent response) and after sublingual intake of 0.01 mg of nitroglycerin (non-endothelium-dependent response) in 12 patients with blood hypertension (group 3), 10 subjects with family hypercholesterolemia (group 2) and 10 healthy subjects (group 1, control).


RESULTS
The flow-dependent dilatation remained unchanged in BH patients (9.4%) and lowered in HCE patients (3.0%) compared to controls (9.5%). Nitroglycerin-induced dilatation was not significantly different in patients with family hypercholesterolemia (16.6%), hypertensive subjects (14.5%) and healthy controls (20.5%).


CONCLUSIONS
The ultrasound method of detection of endothelial dysfunction is demonstrated. Endothelial dysfunction in patients with familial hypercholesterolemia may contribute to development of atherosclerosis.
Balakhonova
T V
TV
Pogorelova
O A
OA
Alidzhanova
Kh G
KhG
Soboleva
G N
GN
At'kov
O Iu
OIu
D000293:Adolescent; D000328:Adult; D001161:Arteriosclerosis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D005996:Nitroglycerin; D012307:Risk Factors; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D005996:Nitroglycerin
Neinvazivnoe opredelenie funktsii éndoteliia u bol'nykh gipertonicheskoĭ bolezn'iu v sochetanii s giperkholesterinemieĭ.