title: Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.
authors.affiliation: Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Ennis
authors.forename: N B
authors.initials: NB
authors.lastname: Ghazal
authors.forename: R L
authors.initials: RL
authors.lastname: Hoffman
authors.forename: M W
authors.initials: MW
authors.lastname: Smith
authors.forename: S K
authors.initials: SK
authors.lastname: Schlachter
authors.forename: C F
authors.initials: CF
authors.lastname: Lawson
authors.forename: W B
authors.initials: WB
authors.lastname: Im
authors.forename: J F
authors.initials: JF
authors.lastname: Pregenzer
authors.forename: K A
authors.initials: KA
authors.lastname: Svensson
authors.forename: R A
authors.initials: RA
authors.lastname: Lewis
authors.forename: E D
authors.initials: ED
authors.lastname: Hall
authors.forename: D M
authors.initials: DM
authors.lastname: Sutter
authors.forename: L T
authors.initials: LT
authors.lastname: Harris
authors.forename: R B
authors.initials: RB
authors.lastname: McCall
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects; D002339:Carotid Arteries / Q000187:drug effects / Q000502:physiology; D002415:Cats; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D004388:Dura Mater / Q000098:blood supply / Q000187:drug effects; D006071:Gorilla gorilla; D006168:Guinea Pigs; D007035:Hypothermia / Q000378:metabolism; D007249:Inflammation / Q000503:physiopathology; D008881:Migraine Disorders / Q000188:drug therapy*; D010879:Piperazines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D013237:Stereoisomerism; D018170:Sumatriptan / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D014655:Vascular Resistance / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D001578:Benzopyrans; C112854:PNU 109291; D010879:Piperazines; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D014662:Vasoconstrictor Agents; D018170:Sumatriptan