[Pathomorphological changes in albino mice infected with plague and treated with cefotaxime].
Pathomorphological and bacteriological changes in albino mice infected with plague and treated with cefotaxime were investigated. The control animals which died within 3 days had structural changes characteristic of generalized plague with lesions in the infection site, regional lymph nodes, spleen, liver and lungs. The plague microbe was isolated from the tissues of all the organs and blood. The animals treated with cefotaxime (200 mg/kg for 7 days) survived. The histological examination conclusively demonstrated the absence of the changes characteristic of generalized plague in their internal organs. The infection process was mainly restricted by the primary complex and was strictly localized. The tissue reaction around the focus in the second part of the experiment developed in accordance with the productive type inflammation followed by the organization and cicatrization. In the bacteriological investigation the plague causative agent was detectable during the first days of the treatment in the site of the infection. During the subsequent days the plague microbe was not detected.
Makarovskaia
L N
LN
Sorokina
T B
TB
Zurabian
V A
VA
Ryzhkova
V V
VV
Markovskaia
E I
EI
D000818:Animals; D002439:Cefotaxime / Q000494:pharmacology / Q000627:therapeutic use*; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000382:microbiology / Q000473:pathology*; D008168:Lung / Q000187:drug effects / Q000382:microbiology / Q000473:pathology*; D008198:Lymph Nodes / Q000187:drug effects / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D010930:Plague / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000382:microbiology / Q000473:pathology*
D002511:Cephalosporins; D002439:Cefotaxime
Patomorfologicheskie izmeneniia v organizme belykh mysheĭ, zarazhennykh chumoĭ i lechennykh tsefotaximom.