Molecular mechanisms of sepsis.
Today a great number of problems in the field of bacterial sepsis remain to be solved. Understanding the molecular mechanisms of one of the most important bacterial products in the pathogenesis of sepsis - endotoxin may contribute to innovative and more effective therapies. Therefore, this review focuses on the structural and functional elements of endotoxin, its interaction with immune cells, and its biological activity. Finally, other bacterial components and their impact on sepsis are discussed.
Woltmann
A
A
Research Center Borstel, Centre for Medicine and Biosciences, Germany.
Hamann
L
L
Ulmer
A J
AJ
Gerdes
J
J
Bruch
H P
HP
Rietschel
E T
ET
D004731:Endotoxins / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D018950:Lipopolysaccharide Receptors / Q000502:physiology; D008070:Lipopolysaccharides / Q000276:immunology; D008262:Macrophage Activation / Q000276:immunology; D011379:Prognosis; D012772:Shock, Septic / Q000276:immunology*; D013530:Surgical Wound Infection / Q000276:immunology*; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology*
D004731:Endotoxins; D018836:Inflammation Mediators; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides