Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
Research into two of the four classes of naturally produced beta-lactams--the clavams and carbapenems--has started to throw light upon their biochemical pathways and underlying genetics. Interesting similarities between these two classes, from their joint discovery to an apparently common beta-lactam ring-forming enzyme, are now being revealed.
McGowan
S J
SJ
Dept of Biochemistry, University of Cambridge, UK.
Bycroft
B W
BW
Salmond
G P
GP
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D015780:Carbapenems / Q000737:chemistry / Q000378:metabolism*; D002969:Clavulanic Acids / Q000737:chemistry / Q000378:metabolism; D047090:beta-Lactams / Q000737:chemistry / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002969:Clavulanic Acids; D047090:beta-Lactams