The effects of cadmium and experimental diabetes on VEP spectral data and lipid peroxidation.
Fifty-two healthy swiss male albino rats, aged three months were used in this study. They were divided into four groups: Control (C), diabetic (D), Cadmium (Cd) and diabetic + Cadmium (D + Cd) groups. Diabetic condition was induced in D and D + Cd groups by administration of alloxane (5 mg/100 g). After this treatment, Cd and D + Cd groups were injected with CdCl2 i.p. (2 mg/kg/week). At the end of the two months of experimental period, flash visual evoked potentials (FVEPs) of four groups were recorded and amplitude spectral analysis was computed by transient response-frequency characteristics (TRFC) method. Significant amplitude decrement was found in 2-4 Hz frequency band of D + Cd group in comparison with C group. On the other hand, our data showed that Cd treatment and diabetic condition caused a significant increase of lipid peroxidation in kidney, brain, retina and lens.
Yargicoglu
P
P
Department of Biophysics, Faculty of Medicine, Akdeniz University, Arapsuyu, Antalya, Turkey.
Agar
A
A
Edremitlioglu
M
M
Kara
C
C
D000704:Analysis of Variance; D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005609:Free Radicals / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D051381:Rats; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014018:Tissue Distribution
D005609:Free Radicals; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D002104:Cadmium