Liddle's syndrome in an elderly woman.
A 78-year-old woman with hypertension was hospitalized with acute bronchitis. However, she was also found to have hypernatremia, hypokalemia, and metabolic alkalosis. Detailed examination showed a low plasma renin activity and plasma aldosterone concentration. A provisional diagnosis of Liddle's syndrome was established and the patient was successfully treated with triamterene. Although Liddle's syndrome is generally considered an inherited hypertensive disease found in young people, a review of the literature indicated that muscle weakness is an important clinical finding in elderly patients with this disease. Liddle's syndrome should be considered in the differential diagnosis of hypertension even in elderly individuals.
Matsushita
T
T
Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto.
Miyahara
Y
Y
Matsushita
M
M
Yakabe
K
K
Yamaguchi
K
K
Furukawa
K
K
Iwasaki
T
T
Naito
T
T
Ikeda
S
S
Miyazaki
M
M
Ogata
H
H
Ohzono
Y
Y
Harada
T
T
Kohno
S
S
D000368:Aged; D000450:Aldosterone / Q000097:blood / Q000172:deficiency; D000471:Alkalosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D003937:Diagnosis, Differential; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006955:Hypernatremia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007008:Hypokalemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D011188:Potassium / Q000627:therapeutic use; D012083:Renin / Q000097:blood / Q000172:deficiency; D013577:Syndrome; D014223:Triamterene / Q000627:therapeutic use
D004232:Diuretics; D000450:Aldosterone; D012083:Renin; D011188:Potassium; D014223:Triamterene