title: An association of hypothalamic hamartoma, central precocious puberty and juvenile granulosa cell tumour in early childhood.
abstract: A case of central precocious puberty from infancy due to a hypothalamic hamartoma and associated with an ovarian juvenile granulosa cell tumour is presented. Central precocious puberty was diagnosed by gonadotropin stimulation tests and LHRH agonist therapy was successful. A MR scan, but not a CT scan, demonstrated the hypothalamic hamartoma. The possible influence of early LH stimulation for the development of the granulosa cell tumour is discussed.
authors.affiliation: Department of Paediatrics, Odense University Hospital, Denmark.
authors.forename: N
authors.initials: N
authors.lastname: Feilberg Jørgensen
authors.forename: B
authors.initials: B
authors.lastname: Brock Jacobsen
authors.forename: S
authors.initials: S
authors.lastname: Ahrons
authors.forename: H
authors.initials: H
authors.lastname: Starklint
mesh_terms: D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood / Q000503:physiopathology*; D006222:Hamartoma / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000097:blood / Q000503:physiopathology*; D007223:Infant; D010051:Ovarian Neoplasms / Q000097:blood / Q000503:physiopathology*; D011629:Puberty, Precocious / Q000097:blood / Q000503:physiopathology*