[Determination of natural antibodies to catecholamines in health and disease].
OBJECTIVE
Enzyme immunoassay (EIA) determination of the level of natural antibodies (n-Ab) to catecholamines in patients with metabolic disturbances and cardiovascular diseases, correlation between content of n-Ab to these bioregulators and clinical diagnosis, biochemical indices.


METHODS
EIA with specially synthetized artificial antigens was used to determine n-Ab to catecholamines (adrenaline, noradrenaline, dopamin) in 41 patients with cardiovascular diseases and metabolic disturbances (ischemic heart disease, essential hypertension, hyperlipoproteinemia) and in 10 healthy subjects (donors, controls).


RESULTS
Changes in the levels of antibodies to catecholamines correspond to the clinical diagnosis. Interrelations exist between n-Ab to catecholamines and biochemical parameters in the disease.


CONCLUSIONS
The trends in the amount of n-Ab to catecholamines are a unique marker of metabolic disturbances of these endogenic substances and can be used in diagnosis.
Miagkova
M A
MA
Savitskaia
Iu A
IuA
Trubacheva
Zh N
ZhN
Panchenko
O N
ON
Pogozheva
A V
AV
Aminova
N M
NM
Rozanova
I A
IA
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D002318:Cardiovascular Diseases / Q000276:immunology*; D002395:Catecholamines / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D008659:Metabolic Diseases / Q000276:immunology*; D012680:Sensitivity and Specificity
D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers; D002395:Catecholamines; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Opredelenie estestvennykh antitel k katekholaminam v norme i pri patologii.