An association of hypothalamic hamartoma, central precocious puberty and juvenile granulosa cell tumour in early childhood.
A case of central precocious puberty from infancy due to a hypothalamic hamartoma and associated with an ovarian juvenile granulosa cell tumour is presented. Central precocious puberty was diagnosed by gonadotropin stimulation tests and LHRH agonist therapy was successful. A MR scan, but not a CT scan, demonstrated the hypothalamic hamartoma. The possible influence of early LH stimulation for the development of the granulosa cell tumour is discussed.
Feilberg Jørgensen
N
N
Department of Paediatrics, Odense University Hospital, Denmark.
Brock Jacobsen
B
B
Ahrons
S
S
Starklint
H
H
D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood / Q000503:physiopathology*; D006222:Hamartoma / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000097:blood / Q000503:physiopathology*; D007223:Infant; D010051:Ovarian Neoplasms / Q000097:blood / Q000503:physiopathology*; D011629:Puberty, Precocious / Q000097:blood / Q000503:physiopathology*