title: MRI of hyperpolarized 3He gas in human paranasal sinuses.
abstract: In this study, MRI of hyperpolarized 3He gas in human paranasal sinuses is presented. Helium images were obtained at 1.5 T, using a surface coil and a 2D, fast gradient-echo sequence with a nominal constant flip angle of 12 degrees. Coronal images of 20-mm thick slices were generated and compared with proton images of the corresponding sections. The images enable visualization of the paranasal sinuses and the nasal cavity, suggesting a potential use of this method not only in identifying the anatomical configuration of these pneumatic spaces, but also in assessing sinus ventilation.
authors.affiliation: Department of Radiology, University of Pennsylvania, Philadelphia 19104-6281, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Rizi
authors.forename: I E
authors.initials: IE
authors.lastname: Dimitrov
authors.forename: A
authors.initials: A
authors.lastname: Thompson
authors.forename: G
authors.initials: G
authors.lastname: Jones
authors.forename: T R
authors.initials: TR
authors.lastname: Gentile
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: R
authors.initials: R
authors.lastname: Reddy
authors.forename: M D
authors.initials: MD
authors.lastname: Schnall
authors.forename: J S
authors.initials: JS
authors.lastname: Leigh
mesh_terms: D000328:Adult; D003287:Contrast Media; D006371:Helium; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation; D007554:Isotopes; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008297:Male; D009296:Nasal Cavity / Q000033:anatomy & histology; D010256:Paranasal Sinuses / Q000033:anatomy & histology*; D012123:Pulmonary Ventilation / Q000502:physiology; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D007554:Isotopes; D006371:Helium