title: [Silicone and autoimmune diseases].
abstract: There exists controversy surrounding the potential relationship between silicone implants and autoimmune diseases. Indeed, silicone is not an inert substance and microparticles from the prosthesis can migrate causing localised or generalised reactions. Most notably, silicone has been associated with sclerodermia and human adjuvant disease. Sclerodermia has been observed within 50% patients suffering from autoimmune diseases linked with silicone. For patients with symptoms, the removal of the prosthesis achieves a favourable response in 50% of the cases. Before a patient undergoes a silicone implant, it is essential that personal and family history of autoimmune disorders are ascertained and evaluated. Also, the patient should undergo regular check ups after having received the implant. In spite of the fact that certain epidemiological studies have not demonstrated a relationship between silicone implants and autoimmune disease, the continual appearance of new cases means that the physician should have an open attitude and be aware of the possibility.
authors.affiliation: Departamento de Medicina, Institut Universitari Dexeus, Barcelona.
authors.forename: J
authors.initials: J
authors.lastname: Alijotas Reig
authors.forename: M I
authors.initials: MI
authors.lastname: García Domingo
mesh_terms: D001327:Autoimmune Diseases / Q000209:etiology*; D006801:Humans; D019736:Prostheses and Implants / Q000009:adverse effects*; D012594:Scleroderma, Localized / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000209:etiology*; D012828:Silicones / Q000009:adverse effects*
chemical_list: D012828:Silicones
vernacular_title: Silicona y enfermedades autoinmunes.