Effect of implantation of human apoAI gene on apoprotein composition and vasoactive properties of high-density lipoproteins in rats at different ages.
Transfer of human apoAI gene, within the molecular construction which provides its expression, to the liver of adult and aged rats resulted in the appearance of human protein in their blood, and was accompanied by changes in the content of high-density lipoproteins, as well as by the shifts in their protein and lipid composition. Administration of the human ApoAI gene was followed by changes of the vasoactive effects of HDL. Gene implantation is capable of enhancing the direct vasodilatory effects of HDL in old animals, being weakened by ageing, even against the background of normal age changes in the vascular wall tone.
Frolkis
V V
VV
Department of Biology of Aging, Institute of Gerontology, AMS Ukraine, Kiev. direct@geront.freenet.kiev.ua
Kulchitsky
O K
OK
Kordjum
V A
VA
Novikova
S N
SN
Sikalo
N V
NV
Potapenko
R I
RI
Irodov
D M
DM
Bogatskaya
L N
LN
Burchinskaya
M K
MK
Mozzhukhina
T G
TG
D000375:Aging / Q000378:metabolism*; D000818:Animals; D016632:Apolipoprotein A-I / Q000235:genetics / Q000502:physiology*; D001059:Apoproteins / Q000378:metabolism*; D018014:Gene Transfer Techniques; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000378:metabolism*
D016632:Apolipoprotein A-I; D001059:Apoproteins; D008075:Lipoproteins, HDL; D014662:Vasoconstrictor Agents