title: The influence of food on the disposition of the antiepileptic rufinamide in healthy volunteers.
abstract: The effect of food on the pharmacokinetics of the antiepileptic rufinamide was investigated in healthy volunteers. Twelve subjects were treated with single pre-oral doses of 600 mg of rufinamide after overnight fasting or a fat and protein rich breakfast. Mean (+/- S.D.) areas under the plasma concentration-time curves (AUCs) of the unchanged compound were 57.2 (16) micrograms mL-1 h when given to the fasted volunteers and 81.7 (22.2) micrograms mL-1 h (p = 0.0001) when given after the breakfast. The average AUC was increased by 44% when rufinamide was given with food and the maximum concentration (Cmax) by about 100%. The time at which Cmax was reached (tmax) was shorter (8 h in fasted conditions and 6 h in fed after breakfast); the terminal half-life was not influenced by concomitant intake of food.
authors.affiliation: Laboratoires Ciba-Geigy, Bioanalytics and Pharmacokinetics (BPK), Rueil-Malmaison, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Cardot
authors.forename: J B
authors.initials: JB
authors.lastname: Lecaillon
authors.forename: C
authors.initials: C
authors.lastname: Czendlik
authors.forename: J
authors.initials: J
authors.lastname: Godbillon
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics*; D019540:Area Under Curve; D018592:Cross-Over Studies; D005260:Female; D018565:Food-Drug Interactions; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D014230:Triazoles / Q000009:adverse effects / Q000493:pharmacokinetics*
chemical_list: D000927:Anticonvulsants; D014230:Triazoles; C079703:rufinamide