Inhibitory effect of radiosensitizer AK-2123 on experimental hepatic metastases and Ca2+ active transport.
A triazole group radiosensitizer AK-2123 is shown to inhibit considerably the growth of hepatic metastases induced by the intrasplenic injection of colon adenocarcinoma cells in syngenic mice. Even an extremely low dose of the drug exhibits the antimetastatic effect. It is shown that AK-2123 injected at therapeutic dose inhibits active transport of calcium ions by the (Ca2+-Mg2+)-dependent ATP-ase. The antimetastatic effect of AK-2123 is suggested to be related, at least partially, to the inhibition of the active calcium transport.
Konovalova
N P
NP
Institute of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region.
Volkova
L M
LM
Tatyanenko
L V
LV
Kotelnikova
R A
RA
Yakushchenko
T N
TN
Kagiya
T V
TV
D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D000818:Animals; D001693:Biological Transport, Active; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000473:pathology; D005260:Female; D008113:Liver Neoplasms / Q000517:prevention & control / Q000556:secondary*; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009368:Neoplasm Transplantation; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
D011838:Radiation-Sensitizing Agents; D014230:Triazoles; C072690:AK 2123; D017301:Ca(2+) Mg(2+)-ATPase; D002118:Calcium