Function-sparing surgery for desmoid tumors and other low-grade fibrosarcomas involving the brachial plexus.
OBJECTIVE
Low-grade fibrosarcomas and desmoid tumors present a surgical challenge in that they have a strong tendency for local invasion, surgical margins are poorly delineated, and complete resections are difficult. Nowhere is this more evident than in those lesions involving the brachial plexus. We review our experience with these difficult lesions.


METHODS
From a prospective database of 2900 patients admitted for treatment of sarcoma between 1982 and 1996, we identified 15 patients with involvement of the brachial plexus by a low-grade fibrosarcoma or desmoid tumor. All patients underwent resection, with 13 of 15 receiving adjuvant radiotherapy. The 15 patients had a mean age at initial operation of 47 years. The male-to-female ratio was 8:7. The mean follow-up period was 65 months (median, 53 mo).


RESULTS
Gross total resection was achieved in 12 patients (80%), although 11 of these patients had positive surgical margins. Overall, 64% of the tumors have recurred locally. There were no distant metastases, and no patients died as a result of their disease. One patient died as a result of unrelated cancer. An assessment of the functional outcomes revealed seven patients with normal function or mild neurological deficits and eight who were suffering from significant weakness, debilitation, or chronic pain. One patient required forequarter amputation.


CONCLUSIONS
Surgical resection plus postoperative radiotherapy is the treatment of choice for low-grade fibrosarcomas and desmoid tumors involving the brachial plexus. However, aggressive surgical management with the goal of achieving a gross total resection with negative histological margins can produce unnecessary morbidity. Preserving function should be a primary goal of the operations, although this will be associated with residual disease and will risk local recurrence but rarely death resulting from the disease.
Gaposchkin
C G
CG
Division of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Bilsky
M H
MH
Ginsberg
R
R
Brennan
M F
MF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001917:Brachial Plexus / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D018222:Desmoid Tumors / Q000503:physiopathology / Q000601:surgery*; D005354:Fibrosarcoma / Q000503:physiopathology / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009420:Nervous System / Q000503:physiopathology; D009423:Nervous System Neoplasms / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D016896:Treatment Outcome