title: Responses of cortical neurons to microiontophoretic application of acetylcholine to their dendrites.
abstract: Spike responses of neurons to the microiontophoretic application of acetylcholine to the soma and the dendrites were studied. The somatic and dendritic membranes had virtually equal sensitivity to acetylcholine. Only activatory responses were seen, which were most typical of spontaneously active neurons. Muscarinic activation induced spike responses with equal latent periods and equal intensities on application of acetylcholine to dendrites and the soma. It is suggested that intracellular chemical signaling is involved in the propagation of cholinergic excitation via dendrites.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
authors.lastname: Mednikova YuS
authors.forename: E V
authors.initials: EV
authors.lastname: Loseva
authors.forename: S V
authors.initials: SV
authors.lastname: Karnup
authors.forename: M N
authors.initials: MN
authors.lastname: Zhadin
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects; D003712:Dendrites / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D005110:Extracellular Space / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007478:Iontophoresis; D008839:Microelectrodes; D018721:Muscarinic Agonists / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D010296:Parietal Lobe / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D013268:Stimulation, Chemical
chemical_list: D018721:Muscarinic Agonists; D000109:Acetylcholine