title: Multiple cases of acquired toxoplasmosis retinitis presenting in an outbreak.
abstract: OBJECTIVE
  The purpose of the study was to examine the variability in presentation and outcome of individuals presenting with acquired toxoplasmosis retinitis in the setting of an outbreak of the disease.
  
  
  METHODS
  The study design was a case series.
  
  
  METHODS
  Twenty-one eyes of 20 patients with equal gender distribution and a mean age of 54 years followed for 38 to 170 weeks (mean 113.7 weeks) were studied.
  
  
  METHODS
  Systemic antimicrobials and corticosteroids when indicated were given.
  
  
  METHODS
  Visual acuity, media inflammation and clarity, resolution of active retinitis, and appearance of recurrence were observed.
  
  
  RESULTS
  Fifteen of 21 lesions were active, and 7 of the total number of lesions fell within the macula-peripapillary region. Overall, vision improved with treatment except in cases of macular involvement (3 cases) and persistent vitritis (3 cases). Four recurrences have occurred to date.
  
  
  CONCLUSIONS
  This is the largest reported outbreak of acquired toxoplasmosis retinitis occurring within a single outbreak. Twenty-one eyes of 20 patients presented with retinal lesions, and on average, those treated for active retinitis had improvement in vision.
authors.affiliation: Provincial Laboratory, British Columbia Center for Disease Control, Vancouver, Canada.
authors.forename: A J
authors.initials: AJ
authors.lastname: Burnett
authors.forename: S G
authors.initials: SG
authors.lastname: Shortt
authors.forename: J
authors.initials: J
authors.lastname: Isaac-Renton
authors.forename: A
authors.initials: A
authors.lastname: King
authors.forename: D
authors.initials: D
authors.lastname: Werker
authors.forename: W R
authors.initials: WR
authors.lastname: Bowie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001955:British Columbia / Q000453:epidemiology; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012173:Retinitis / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D014122:Toxoplasma / Q000276:immunology; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy / Q000453:epidemiology* / Q000469:parasitology; D014792:Visual Acuity
chemical_list: D000981:Antiprotozoal Agents; D005938:Glucocorticoids; D007136:Immunoglobulins