title: The role of chemokines in tissue inflammation and autoimmunity in renal diseases.
abstract: Chemokines are an expanding family of chemoattractant polypeptides involved in the extravasation of leukocytes during the inflammatory process. This review highlights recent advances in the field, including the discovery of a new class of chemokines, and several novel receptors. In addition, the expanding role of chemokines in pathologic processes other than extravasation and their potential as therapeutic targets are discussed.
authors.affiliation: Inflammation Division, Millennium Pharmaceuticals Inc., Cambridge, Massachusetts, USA.
authors.forename: C
authors.initials: C
authors.lastname: Lloyd
authors.forename: J C
authors.initials: JC
authors.lastname: Gutierrez-Ramos
mesh_terms: D000818:Animals; D015551:Autoimmunity; D018925:Chemokines / Q000145:classification / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D009393:Nephritis / Q000209:etiology; D019707:Receptors, Chemokine / Q000502:physiology
chemical_list: D018925:Chemokines; D018836:Inflammation Mediators; D019707:Receptors, Chemokine