title: Genetic and immunological host factors associated with susceptibility to HIV-1 infection.
abstract: The probability of HIV transmission depends on the interplay of many different factors related to infectiousness of the HIV-infected partner, susceptibility of the HIV-uninfected partner, and biological characteristics of HIV strains. Here, we review recent studies of host immunological and genetic factors which may affect susceptibility to HIV-1 infection. These factors are summarized in Table 1. We propose how to explore biological correlates of susceptibility to HIV-1 infection in epidemiological studies, discuss the strengths and limitations of this research, and address the implications for public health.
authors.affiliation: Department of Epidemiology, University of California, Berkeley, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Buchacz
authors.forename: D A
authors.initials: DA
authors.lastname: Wilkinson
authors.forename: J F
authors.initials: JF
authors.lastname: Krowka
authors.forename: R A
authors.initials: RA
authors.lastname: Koup
authors.forename: N S
authors.initials: NS
authors.lastname: Padian
mesh_terms: D004198:Disease Susceptibility; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D019707:Receptors, Chemokine; D011991:Receptors, Virus; D012307:Risk Factors
chemical_list: D019707:Receptors, Chemokine; D011991:Receptors, Virus