Hereditary CD4+ T lymphocytopenia.
Two siblings suffering from mental retardation, progressive bronchiectasis, extensive warts, and persistent hepatitis B are described. The propositus also had an unusual physiognomy and non-specific colitis. Both patients had a marked decrease in the population of CD4+ helper T cells.
Freier
S
S
Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem, Israel.
Kerem
E
E
Dranitzki
Z
Z
Schlesinger
M
M
Rabinowitz
R
R
Brautbar
C
C
Ashkirat
M
M
Naparstek
Y
Y
D000293:Adolescent; D001987:Bronchiectasis / Q000209:etiology / Q000276:immunology; D003092:Colitis / Q000150:complications / Q000276:immunology; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000276:immunology; D006801:Humans; D008297:Male; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications / Q000235:genetics* / Q000276:immunology; D014860:Warts / Q000150:complications / Q000276:immunology