title: Somatic and germline clone analysis in mutants of the S-adenosylmethionine synthetase encoding gene in Drosophila melanogaster.
abstract: We have analysed the phenotypic consequences of homozygous mutant clones in the S-adenosylmethionine synthetase encoding gene in Drosophila melanogaster. The results suggest that SamS function is required for cell proliferation/growth in embryonic/early larval cells and during development of imaginal disc cells. Homozygous SamS germline clones can, however, develop and give rise to viable heterozygous offspring. This offspring expresses a Minute-like phenotype. We suggest that this phenotype is caused by an obstruction of the polyamine biosynthesis.
authors.affiliation: Department of Genetics, Umeå University, Sweden. jan.larsson@genetik.umu.se
authors.forename: J
authors.initials: J
authors.lastname: Larsson
authors.forename: A
authors.initials: A
authors.lastname: Rasmuson-Lestander
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000196:embryology / Q000201:enzymology / Q000235:genetics*; D005260:Female; D008297:Male; D008716:Methionine Adenosyltransferase / Q000235:genetics*; D010641:Phenotype
chemical_list: D008716:Methionine Adenosyltransferase