Spatial determinants of specificity in insulin action.
Insulin is a potent stimulator of intermediary metabolism, however the basis for the remarkable specificity of insulin's stimulation of these pathways remains largely unknown. This review focuses on the role compartmentalization plays in insulin action, both in signal initiation and in signal reception. Two examples are discussed: (1) a novel signalling pathway leading to the phosphorylation of the caveolar coat protein caveolin, and (2) a recently identified scaffolding protein, PTG, involved directly in the regulation of enzymes controlling glycogen metabolism.
Mastick
C C
CC
Department of Cell Biology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA.
Brady
M J
MJ
Printen
J A
JA
Ribon
V
V
Saltiel
A R
AR
D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000502:physiology*; D011972:Receptor, Insulin / Q000378:metabolism; D013379:Substrate Specificity
D007328:Insulin; D011972:Receptor, Insulin