title: Immunolymphoscintigraphy in breast cancer: evaluation using 131I-labeled monoclonal antibody B72.3.
abstract: Noninvasive axillary lymph node staging was investigated using [131I]murine monoclonal antibody B72.3 in 16 patients with breast cancer scheduled for axillary dissection. [131I]B72.3 was injected into ipsilateral finger webs or around the breast biopsy. Scintigraphy to 72 h and gamma-counting/immunohistochemistry of nodes were performed. Specific antibody uptake (%ID/g) and the ratio of specific:nonspecific antibody uptake were not significantly different in tumor-positive versus tumor-negative nodes, suggesting that [131I]B72.3 is unsuitable to discriminate axillary node tumor involvement.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Fig
authors.forename: R S
authors.initials: RS
authors.lastname: Brown
authors.forename: L
authors.initials: L
authors.lastname: von Moll
authors.forename: H D
authors.initials: HD
authors.lastname: Appelman
authors.forename: R
authors.initials: R
authors.lastname: Stevens
authors.forename: J
authors.initials: J
authors.lastname: Harness
authors.forename: D
authors.initials: D
authors.lastname: August
authors.forename: V K
authors.initials: VK
authors.lastname: Sondak
authors.forename: A E
authors.initials: AE
authors.lastname: Chang
authors.forename: K R
authors.initials: KR
authors.lastname: Zasadny
authors.forename: S J
authors.initials: SJ
authors.lastname: Fisher
authors.forename: J W
authors.initials: JW
authors.lastname: Johnson
authors.forename: M S
authors.initials: MS
authors.lastname: Wicha
authors.forename: D
authors.initials: D
authors.lastname: Colcher
authors.forename: A S
authors.initials: AS
authors.lastname: Lichter
authors.forename: R L
authors.initials: RL
authors.lastname: Wahl
mesh_terms: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm / Q000032:analysis; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging* / Q000473:pathology; D009367:Neoplasm Staging; D016719:Radioimmunodetection; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; C091202:B72.3 antibody; D006023:Glycoproteins; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; C047052:tumor-associated antigen 72