[Human papillomavirus, neonatal giant cell hepatitis and biliary duct atresia].
We previously recognized the presence of HPV-DNA in cases of idiopathic neonatal giant cell hepatitis (INGCH) and extrahepatic biliary duct atresia (EBDA) in archivated tissue using the PCR technique. In order to investigate a possible vertical transmission we looked for the presence of HPV-DNA in cervical swabs in the mothers along with formalin-fixed paraffin-embedded hepatic tissue from 3 infants with INGCH and 4 patients with EBDA by nested-PCR. Cervical smears showed koilocytosis consistent with HPV infection in 2 cases. Delivery was vaginal except for one that was by cesarean section. All infants were males. Amplification of HPV-DNA was demonstrated in all cases, the types being concordant in infants and mothers. Although this is a small group, the findings appear in line with previous data. The presence of the same type of HPV-DNA in the infants' livers and their mothers' cervical swabs is another argument supporting the possibility of vertical transmission of the virus.
Drut
R
R
Servicio de Anatomía Patológica, Hospital de Niños Sor María Ludovica, La Plata.
Gómez
M A
MA
Drut
R M
RM
Cueto
R E
RE
Lojo
M
M
D001656:Biliary Atresia / Q000821:virology*; D001724:Birth Weight; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015726:Giant Cells; D006505:Hepatitis / Q000151:congenital* / Q000821:virology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008099:Liver / Q000473:pathology / Q000821:virology; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000635:transmission
D004279:DNA, Viral
Virus papiloma humano, hepatitis gigantocelular neonatal y atresia de vías biliares.