The effect of aqueous humor suppressants on intravitreal gas bubble duration in rabbits.
OBJECTIVE
To evaluate the effect of topical aqueous humor suppressants on the absorption of intravitreal perfluorocarbon gases.


METHODS
Sulfur hexafluoride or perfluoropropane was injected intravitreally in five rabbits. Time to gas disappearance was measured in eyes treated with topical aqueous humor suppressants and in those not treated.


RESULTS
The mean time (+/- SD) to disappearance of 0.4 cc of sulfur hexafluoride was 5.6 +/- 0.9 days, which was prolonged by 43% to 8.0 +/- 0.7 days with topical aqueous humor suppressants (P = .009). The mean time (+/- SD) to disappearance of 0.2 cc of perfluoropropane was 18.4 +/- 1.9 days, which was prolonged by 55% to 28.6 +/- 2.7 days with topical aqueous humor suppressants (P = .009).


CONCLUSIONS
Aqueous suppressants prolong sulfur hexafluoride and perfluoropropane intravitreal gas bubble duration in rabbits.
Lee
M S
MS
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510, USA.
Pasha
M
M
Weitzman
M
M
D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects*; D003000:Clonidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005466:Fluorocarbons / Q000378:metabolism*; D007267:Injections; D007429:Intraocular Pressure; D011817:Rabbits; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D013459:Sulfur Hexafluoride / Q000378:metabolism*; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D013999:Timolol / Q000008:administration & dosage / Q000494:pharmacology*; D014822:Vitreous Body / Q000378:metabolism*
D005466:Fluorocarbons; D013449:Sulfonamides; D013876:Thiophenes; D013999:Timolol; C016986:apraclonidine; C062765:dorzolamide; C042852:perflutren; D003000:Clonidine; D013459:Sulfur Hexafluoride