[Blood lipids, lipid peroxidation and the effect on them of antianginal preparations in ischemic heart disease patients].
The origin and development of ischemic heart disease (IHD) is attended with activation of lipid free-radical oxidation facilitating further advancement of the disease and with decrease of the organism's antioxidant protection. The antianginal drugs which are used in IHD treatment differ in their effect on the blood lipid composition and their peroxidation. beta-Adrenoblocking agents may cause proatherogenic disorders of the blood lipid graph, this increases the risk of IHD advancement. Long-acting nitro preparations are lipid-neutral. Calcium antagonists, mainly those of the nifedipin group, suppress LPO superactivity, possess a high antioxidant effect, and, probably, retard the advancement of coronary atherosclerosis and IHD.
Serkova
V K
VK
Department of Therapy, Pirogov Vinnitsa Medical University, Ukraine.
Zhebel'
V N
VN
Filenko
L V
LV
Savitskaia
E A
EA
D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D005609:Free Radicals / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D017202:Myocardial Ischemia / Q000097:blood* / Q000188:drug therapy*
D002317:Cardiovascular Agents; D005609:Free Radicals; D008055:Lipids
Lipidy krovi, lipoperoksidatsiia i vliianie na nikh antianginal'nykh preparatov u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.