title: CD8-positive mantle cell lymphoma: a report of two cases.
abstract: Two cases of mantle cell lymphoma with a unique CD8+ phenotype are reported. Both patients had disease that was resistant to therapy; one patient had the blastic variant of mantle cell lymphoma. Flow cytometric analysis of bone marrow and cerebrospinal fluid samples revealed a phenotype consistent with mantle cell lymphoma, with the additional finding of CD8 positivity in 40% or more of the tumor cells in both cases. This is the first description of such a finding, and CD8+ mantle cell lymphoma may represent a unique type of B-cell neoplasia. Our findings may be important in the prediction of therapeutic response or in the detection of residual disease after therapy.
authors.affiliation: Department of Pathology, Center for the Health Sciences, University of California, Los Angeles 90095, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Hoffman
authors.forename: S J
authors.initials: SJ
authors.lastname: Tucker
authors.forename: C
authors.initials: C
authors.lastname: Emmanoulides
authors.forename: P A
authors.initials: PA
authors.lastname: Rosen
authors.forename: F
authors.initials: F
authors.lastname: Naeim
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis; D001854:Bone Marrow Cells / Q000276:immunology; D017252:CD3 Complex / Q000032:analysis; D018956:CD5 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D006801:Humans; D016130:Immunophenotyping; D008228:Lymphoma, Non-Hodgkin / Q000134:cerebrospinal fluid / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000032:analysis
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex; D018956:CD5 Antigens; D016827:CD8 Antigens; D005456:Fluorescent Dyes; D017455:Receptors, IgE; D016650:Fluorescein-5-isothiocyanate