Anticardiolipin antibodies and thromboembolism after BMT.
We describe a 4-month-old child who developed unusual thrombotic complications following allogeneic BMT for Omenn syndrome, a form of SCID. Eight weeks after the procedure the child suffered a major cerebrovascular accident and developed acute pulmonary hypertension in association with persistently elevated anticardiolipin antibody titres. It is postulated that central line-derived microemboli caused these serious thrombotic complications in the context of an evolving hypercoaguable state.
Qasim
W
W
Blood and Bone Marrow Transplantation Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK.
Gerritsen
B
B
Veys
P
P
D017153:Antibodies, Anticardiolipin / Q000097:blood*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D016511:Severe Combined Immunodeficiency / Q000628:therapy*; D013923:Thromboembolism / Q000209:etiology*
D017153:Antibodies, Anticardiolipin