title: Mild cognitive impairment and risk of mortality in HIV-1 infection.
abstract: HIV-1-associated cognitive impairment has only been preliminarily investigated for associations with mortality. The authors examined 119 HIV-1-positive homosexual men (asymptomatic: n = 96; early symptomatic: n = 23). At follow-up (to 3.5 years), there were 105 survivors and 14 nonsurvivors. Those at the 25th percentile in response speeds and in long-term memory retrieval accuracy were at 6.4 (P < 0.02) and 3.5 (P < 0.05) times increased mortality risk, respectively, of those at the 75th percentile--independent of baseline CDC clinical stage, CD4 cell count, hemoglobin level, antiretroviral and prophylactic medication use, and sociodemographics. Cognitive impairment should be identified early--for maximization of both functional status and survival time.
authors.affiliation: Department of Psychiatry, University of Miami School of Medicine, Florida 33136, USA.
authors.forename: F L
authors.initials: FL
authors.lastname: Wilkie
authors.forename: K
authors.initials: K
authors.lastname: Goodkin
authors.forename: C
authors.initials: C
authors.lastname: Eisdorfer
authors.forename: D
authors.initials: D
authors.lastname: Feaster
authors.forename: R
authors.initials: R
authors.lastname: Morgan
authors.forename: M A
authors.initials: MA
authors.lastname: Fletcher
authors.forename: N
authors.initials: N
authors.lastname: Blaney
authors.forename: M
authors.initials: M
authors.lastname: Baum
authors.forename: J
authors.initials: J
authors.lastname: Szapocznik
mesh_terms: D015526:AIDS Dementia Complex / Q000401:mortality*; D000328:Adult; D018450:Disease Progression; D005431:Florida / Q000453:epidemiology; D005500:Follow-Up Studies; D015497:HIV-1; D018451:Homosexuality, Male / Q000706:statistics & numerical data; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008569:Memory Disorders / Q000453:epidemiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D016017:Odds Ratio; D011379:Prognosis; D016016:Proportional Hazards Models; D011930:Reaction Time; D012307:Risk Factors