Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human matrix Gla protein (MGP) locus.
Matrix Gla protein (MGP) is an 84-residue, vitamin K-dependent protein expressed by chondrocytes and vascular smooth muscle cells, and is a potent regulator of calcium deposition in cartilage and arterial wall. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human MGP gene. This polymorphism will be useful in genetic studies of arteriosclerosis and osteoporosis.
Watanabe
I
I
Department of Molecular Biology, Nippon Medical School, Kawasaki, Japan.
Tsukamoto
K
K
Shiba
T
T
Emi
M
M
D000483:Alleles; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D017931:DNA Primers / Q000235:genetics; D018900:Dinucleotide Repeats; D016326:Extracellular Matrix Proteins; D005787:Gene Frequency; D006801:Humans; D006822:Hybrid Cells; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D000097568:Matrix Gla Protein
D002135:Calcium-Binding Proteins; D017931:DNA Primers; D016326:Extracellular Matrix Proteins; D000097568:Matrix Gla Protein