title: Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency.
abstract: In humans, interferon gamma (IFN-gamma) receptor deficiency leads to a predisposition to mycobacterial infections and impairs the formation of mature granulomas. Interleukin-12 (IL-12) receptor deficiency was found in otherwise healthy individuals with mycobacterial infections. Mature granulomas were seen, surrounded by T cells and centered with epithelioid and multinucleated giant cells, yet reduced IFN-gamma concentrations were found to be secreted by activated natural killer and T cells. Thus, IL-12-dependent IFN-gamma secretion in humans seems essential in the control of mycobacterial infections, despite the formation of mature granulomas due to IL-12-independent IFN-gamma secretion.
authors.affiliation: INSERM U429, Hôpital Necker-Enfants Malades, Paris 75015, France.
authors.forename: F
authors.initials: F
authors.lastname: Altare
authors.forename: A
authors.initials: A
authors.lastname: Durandy
authors.forename: D
authors.initials: D
authors.lastname: Lammas
authors.forename: J F
authors.initials: JF
authors.lastname: Emile
authors.forename: S
authors.initials: S
authors.lastname: Lamhamedi
authors.forename: F
authors.initials: F
authors.lastname: Le Deist
authors.forename: P
authors.initials: P
authors.lastname: Drysdale
authors.forename: E
authors.initials: E
authors.lastname: Jouanguy
authors.forename: R
authors.initials: R
authors.lastname: Döffinger
authors.forename: F
authors.initials: F
authors.lastname: Bernaudin
authors.forename: O
authors.initials: O
authors.lastname: Jeppsson
authors.forename: J A
authors.initials: JA
authors.lastname: Gollob
authors.forename: E
authors.initials: E
authors.lastname: Meinl
authors.forename: A W
authors.initials: AW
authors.lastname: Segal
authors.forename: A
authors.initials: A
authors.lastname: Fischer
authors.forename: D
authors.initials: D
authors.lastname: Kumararatne
authors.forename: J L
authors.initials: JL
authors.lastname: Casanova
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D005260:Female; D006099:Granuloma / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism; D018664:Interleukin-12 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D015270:Mycobacterium avium-intracellulare Infection / Q000276:immunology*; D009163:Mycobacterium bovis; D010375:Pedigree; D017471:Receptors, Interferon / Q000235:genetics / Q000276:immunology; D018123:Receptors, Interleukin / Q000172:deficiency / Q000235:genetics*; D053707:Receptors, Interleukin-12; D013601:T-Lymphocytes / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology*; D000096743:Interferon gamma Receptor
chemical_list: D007371:Interferon-gamma; D018664:Interleukin-12; D017471:Receptors, Interferon; D018123:Receptors, Interleukin; D053707:Receptors, Interleukin-12; D000096743:Interferon gamma Receptor