[Evaluation of antiviral activity of new medicinal forms of foscarnet in genital herpes in guinea pigs].
Antiviral activity of a Russian drug foscarnet (tablets and coated pills) was assessed in guinea pigs with experimental genital herpes. New dosage forms were well tolerated by the animals, causing no manifest symptoms of intoxication irrespective of the doses or protocols of the drug use, Foscarnet in any dosage form in the total daily dose of at least 120 mg/kg had a pronounced antiviral effect towards herpes simplex type II virus, comparable with that of the commercial reference drug virolex: the intensity of clinical symptoms was alleviated and the disease duration shortened.
Alimbarova
L M
LM
Barinskiĭ
I F
IF
Kuz'min
K K
KK
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004304:Dosage Forms; D017245:Foscarnet / Q000008:administration & dosage / Q000627:therapeutic use*; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy*; D008297:Male
D000998:Antiviral Agents; D004304:Dosage Forms; D017245:Foscarnet
Otsenka protivovirusnoĭ aktivnosti novykh lekarstvennykh form foskarneta pri genital'nom gerpese morskikh svinok.