title: The prevention of peridural adhesions. A comparative long-term histomorphometric study using a biodegradable barrier and a fat graft.
abstract: We studied peridural fibrosis in 16 dogs after laminectomies at the L2, L4 and L6 levels. They received either a free fat graft, a biodegradable mechanical barrier (polyethylene oxide (PEO)/polybutylene terephthalate (PBT) copolymer), or no treatment. The animals were killed after 4, 12, 26 and 52 weeks. Histomorphometry showed extensive and consistent peridural fibrosis in control and PEO/PBT groups. Fat grafts produced significantly less fibrous tissue, but the presence of the fat graft in the bony defect prevented closure. Degradation of the PEO/PBT barrier resulted in the formation of more fibrous tissue. We conclude that up to one year a free fat graft is effective in reducing the amount of peridural scarring.
authors.affiliation: University of Utrecht, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Quist
authors.forename: W J
authors.initials: WJ
authors.lastname: Dhert
authors.forename: B P
authors.initials: BP
authors.lastname: Meij
authors.forename: W J
authors.initials: WJ
authors.lastname: Visser
authors.forename: F C
authors.initials: FC
authors.lastname: Oner
authors.forename: H A
authors.initials: HA
authors.lastname: Hazewinkel
authors.forename: A J
authors.initials: AJ
authors.lastname: Verbout
mesh_terms: D000273:Adipose Tissue / Q000473:pathology / Q000637:transplantation*; D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control; D003094:Collagen; D004285:Dogs; D004388:Dura Mater / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D005500:Follow-Up Studies; D007796:Laminectomy / Q000009:adverse effects*; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000473:pathology / Q000601:surgery; D008297:Male; D008567:Membranes, Artificial; D011091:Polyesters; D011092:Polyethylene Glycols; D011446:Prospective Studies; D011897:Random Allocation; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011091:Polyesters; C072932:polyethylene oxide-polybutylene terephthalate copolymer; D011092:Polyethylene Glycols; D003094:Collagen