title: Protection of mice against Plasmodium yoelii sporozoite challenge with P. yoelii merozoite surface protein 1 DNA vaccines.
abstract: Immunization of mice with DNA vaccines encoding the full-length form and C and N termini of Plasmodium yoelii merozoite surface protein 1 provided partial protection against sporozoite challenge and resulted in boosting of antibody titers after challenge. In C57BL/6 mice, two DNA vaccines provided protection comparable to that of recombinant protein consisting of the C terminus in Freund's adjuvant.
authors.affiliation: Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20889-5607, USA.
authors.forename: S I
authors.initials: SI
authors.lastname: Becker
authors.forename: R
authors.initials: R
authors.lastname: Wang
authors.forename: R C
authors.initials: RC
authors.lastname: Hedstrom
authors.forename: J C
authors.initials: JC
authors.lastname: Aguiar
authors.forename: T R
authors.initials: TR
authors.lastname: Jones
authors.forename: S L
authors.initials: SL
authors.lastname: Hoffman
authors.forename: M J
authors.initials: MJ
authors.lastname: Gardner
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics*; D005260:Female; D007114:Immunization; D017780:Malaria Vaccines / Q000276:immunology*; D020066:Merozoite Surface Protein 1; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010967:Plasmodium yoelii / Q000276:immunology*; D011498:Protein Precursors / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D019444:Vaccines, DNA / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D000953:Antigens, Protozoan; D017780:Malaria Vaccines; D020066:Merozoite Surface Protein 1; D011498:Protein Precursors; D015800:Protozoan Proteins; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic