[The effect of antibodies on the Ca2+ release from the sarcoplasmic reticulum of the papillary muscle of the rat heart].
In experiments of skinned with saponin papillary muscles (PM) of the rat's heart we studied the effects of antibodies (AB), which are specific for the sarcoplasmic reticulum's membranes (SPR). AB (1-5 mg protein/ml) have been established to enhance the amplitude of the isometric PM tension. Inhibition of the Ca2+ release from SPR and its previous release prevented the development of the exciting effect of AB. Thus, AB increase the amplitude of PM contraction due to their intracellular mobilizing action.
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A. A. Bogomoletz Institute of Physiology, Nat. Acad. Sci., Kiev.
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000918:Antibody Specificity; D002118:Calcium / Q000378:metabolism*; D004306:Dose-Response Relationship, Immunologic; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D000906:Antibodies; D002118:Calcium
Vplyv antytil na vykhid Ca2+ iz sarkoplazmatychnoho retikuluma papiliarnoho m'iaza sertsia shchura.