Theanine-induced reduction of brain serotonin concentration in rats.
Following the administration of theanine, the brain tryptophan content significantly increased or tended to increase, but the contents of serotonin and 5-hydroxyindole acetic acid (5HIAA) decreased. The use of inhibitors of serotonin metabolism enable us to speculate that theanine reduced serotonin synthesis and also increased serotonin degradation in the brain.
Yokogoshi
H
H
Laboratory of Nutritional Biochemistry, School of Food and Nutritional Sciences, University of Shizuoka, Japan. yokogosi@fnsl.u-shizuoka-ken.ac.jp
Mochizuki
M
M
Saitoh
K
K
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D010134:Fenclonine / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014364:Tryptophan / Q000378:metabolism
D005971:Glutamates; D008996:Monoamine Oxidase Inhibitors; D012702:Serotonin Antagonists; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C026166:theanine; D014364:Tryptophan; D010293:Pargyline; D010134:Fenclonine