[The immunotropic properties of rifampicin and their correction].
The effect of rifampicin on antibody genesis depends on the dose, duration, and time of its administration in relation to the antigen, as well as on the character of immunosuppression. The antibiotic has no effect on delayed hypersensitivity and stimulates the activity of phagocytes, predominantly that of neutrophils. The effectiveness of rifampicin in experimental infection is maintained in treatment with cyclophosphane and azathioprine. When administered in combination with rifampicin and cytostatics methyluracil possesses a broader spectrum of immunostimulating activity than that of prodigiosin and levamisole.
Sakaeva
D D
DD
Bashkirian State Medical University, Ufa, Russia.
Lazareva
D N
DN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D001379:Azathioprine / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D010586:Phagocytes / Q000187:drug effects / Q000276:immunology; D011512:Proteus Infections / Q000276:immunology / Q000401:mortality; D011513:Proteus mirabilis; D012293:Rifampin / Q000494:pharmacology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000904:Antibiotics, Antitubercular; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D001379:Azathioprine; D012293:Rifampin
Immunotropnye svoĭstva rifampitsina i ikh korrektsiia.