Isolation and mapping of a polymorphic CA repeat sequence at the human interleukin 6 locus.
A polymorphic dinucleotide (CA) sequence was isolated from a genomic clone containing the human interleukin 6 (interferon beta-2) gene and was mapped to 7p21. This polymorphism will be useful in the genetic study of disorders affecting the inflammation process, calcium metabolism, and hematologic malignancies.
Tsukamoto
K
K
Department of Molecular Biology, Nippon Medical School, Kawasaki, Japan.
Haruta
K
K
Shiba
T
T
Emi
M
M
D000483:Alleles; D001483:Base Sequence; D002118:Calcium / Q000378:metabolism; D002874:Chromosome Mapping; D017931:DNA Primers / Q000235:genetics; D018900:Dinucleotide Repeats; D005787:Gene Frequency; D006402:Hematologic Diseases / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D007249:Inflammation / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D017931:DNA Primers; D015850:Interleukin-6; D002118:Calcium