Primary central nervous system lymphoma in a child with acute B-cell lymphoblastic leukaemia: consecutive Epstein-Barr virus-related malignancies.
Primary central nervous system lymphoma (PCNSL), observed among immunocompromised AIDS patients, has not been reported during chemotherapy for acute lymphoblastic leukaemia (ALL). We report a case of PCNSL occurring in a child receiving intensive multiagent chemotherapy for B-cell ALL. In situ hybridization studies demonstrated Epstein-Barr virus genome in both tumours, suggesting a possible link between the two diseases. The clinical response of the PCNSL to conservative therapy highlights the importance of accurately diagnosing such EBV-related disorders, especially in patients where immune compromise can be reversed.
Buckingham
S C
SC
Department of Infectious Disease, St Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.
Benaim
E
E
Sandlund
J T
JT
Gan
Y J
YJ
Freiden
P J
PJ
Behm
F G
FG
Ribeiro
R C
RC
Sixbey
J W
JW
Slobod
K S
KS
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002051:Burkitt Lymphoma / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D009894:Opportunistic Infections / Q000150:complications; D012367:RNA, Viral / Q000032:analysis
D012367:RNA, Viral