title: Survival in patients with primary soft-tissue sarcomas treated within 6 years.
abstract: Since 1988, treatment strategies for our sarcoma patients have been determined by the same team and operations performed by one surgeon. The aim of this study was to analyse prognostic data on local recurrence and survival of 101 consecutive patients who presented in our institution with the primary tumour manifestation. After a median follow-up of 35 months, the local recurrence rate was 13.5%, the mean survival time was 68 months and the 5-year survival rate was 83%. Besides positive lymph nodes (only 3 patients) the quality of resection significantly influenced local recurrences (P < 0.05). Univariate predictors of mortality were tumour grade (P < 0.01), tumour size (P < 0.05), distant metastases (P < 0.01), and resection quality (P < 0.01). Multivariate predictors of mortality consisted of grade (P < 0.0001), positive lymph nodes (P < 0.001) and resection quality (P < 0.01). In this homogeneous group of patients, excellent recurrence and survival rates could be achieved. An optimized surgical treatment not only reduces the rate of local recurrences but also augments survival time.
authors.affiliation: Abteilung für Allgemeinchirurgie, Universitäts-Krankenhaus Eppendorf, Hamburg, Germany. peiper@compuserve.com
authors.forename: M
authors.initials: M
authors.lastname: Peiper
authors.forename: D
authors.initials: D
authors.lastname: Zurakowski
authors.forename: R
authors.initials: R
authors.lastname: Schwarz
authors.forename: H J
authors.initials: HJ
authors.lastname: Weh
authors.forename: C
authors.initials: C
authors.lastname: Zornig
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology / Q000628:therapy; D006801:Humans; D008080:Liposarcoma / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009442:Neurilemmoma / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012509:Sarcoma / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*