Preoperative serum vascular endothelial growth factor can predict stage in colorectal cancer.
Neovascularization has been shown to be essential for the growth of solid tumors. Vascular endothelial growth factor (VEGF) is one of the most important mediators of angiogenesis. This study was conducted to determine the significance of this cytokine as a tumor marker for staging colorectal cancer. Preoperative serum VEGF was measured in 108 colorectal cancer patients and in 136 normal healthy controls. The results of this study showed a significant difference between the four T classes, Union International Contre Cancer (UICC) stages, and Dukes' stages. In comparison to serum levels in controls (median, 173.8 pg/ml), VEGF levels were significantly elevated in T2 (P = 0.003), T3, and T4 (P < 0.0005); UICC I (P = 0.001), UICC II, UICC III, and UICC IV (P < 0.0005); and Dukes' A (P = 0.001), Dukes' B, and Dukes' C (P < 0.0005). Serum VEGF showed a significant elevation over control in node-negative (P < 0.0005) and in node-positive colorectal cancer (P < 0.0005) patients. Node-positive cancer had a significant elevation of serum VEGF compared to node-negative cancer (P = 0.008). This study reveals that preoperative serum VEGF can detect all but very early colorectal cancer i.e., T1 (P = 0.06).
Kumar
H
H
University of Hull Academic Surgical Unit, Castle Hill Hospital, Cottingham, United Kingdom.
Heer
K
K
Lee
P W
PW
Duthie
G S
GS
MacDonald
A W
AW
Greenman
J
J
Kerin
M J
MJ
Monson
J R
JR
D000328:Adult; D000704:Analysis of Variance; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology*; D016228:Endothelial Growth Factors / Q000097:blood*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008222:Lymphokines / Q000097:blood*; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D009367:Neoplasm Staging; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D009363:Neoplasm Proteins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors