title: Initial interfacial healing events around calcium phosphate (Ca-P) coated oral implants.
abstract: The bone response to different calcium phosphate (Ca-P) coated and non-coated titanium implants was evaluated in a goat animal model. Two types of Ca-P coatings have been investigated: an experimental plasma-spray bilayered Ca-P coating (FA-HA) and an amorphous RF magnetron sputter coating (Ca-P-a). Fifty-four conical screw shaped implants were inserted in the lateral and medial femoral condyles of 18 Saanen goats. After implantation periods of 3, 12 and 24 days, the bone-implant interface was evaluated histologically and histomorphometrically. Light microscopical evaluation revealed that bone formation on the Ca-P coated implants proceeded faster. At 24 days higher percentages of bone contact were measured for both Ca-P coated implants than for non-coated implants. However, this difference was only significant for the FA-HA coated implants. On basis of these findings, we concluded that Ca-P coatings show improved bone response due to an initial difference in bone cell response.
authors.affiliation: Dental School, University of Nijmegen, Department of Biomaterials, The Netherlands.
authors.forename: J E
authors.initials: JE
authors.lastname: Hulshoff
authors.forename: J A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D002130:Calcium Phosphates; D015921:Dental Implants; D017267:Dental Prosthesis Design; D005260:Female; D005269:Femur / Q000601:surgery; D006041:Goats; D020007:Implants, Experimental; D016348:Osseointegration; D013499:Surface Properties; D014945:Wound Healing / Q000502:physiology
chemical_list: D002130:Calcium Phosphates; D015921:Dental Implants