title: [Therapeutic potential of Granisetron (Kitryl) for the prevention of nausea and vomiting induced by cytostatic drugs].
abstract: Oral administration of 2 mg kitryl effectively controlled nausea (82.5-96.7%) and vomiting (97.3-99.1%) induced in 127 patients with malignant lymphomas and solid tumors, who received highly emetic cytostatic MOPP, ABVD, CHOP, CHOEP, EVAP, VP and CMP therapy. The antiemetic effect of oral administration was identical to that of intravenous injection of 3 mg.
authors.affiliation: Prof. N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
authors.forename: M L
authors.initials: ML
authors.lastname: Gershanovich
authors.forename: I A
authors.initials: IA
authors.lastname: Beresneva
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D005260:Female; D017829:Granisetron / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D017829:Granisetron
vernacular_title: Vozmozhnosti primeneniia Granisetrona (Kitrila) dlia preduprezhdeniia rvoty i toshnoty, vyzvannoĭ tsitostatikami.