title: Long-term survival in cerebral glioblastoma. Case report and critical review of the literature.
abstract: Glioblastoma multiforme is the most malignant tumor of the glial series. The average survival of patients with this tumor ranges from 6 to 12 months. The case of a patient who survived for more than 11 years after diagnosis of a temporal-occipital glioblastoma which was treated with surgery, radiotherapy and chemotherapy is described. The authors deduce that among patients with glioblastoma multiforme (GM), those with a long disease-free interval after initial diagnosis who undergo multimodal therapy, including aggressive tumor removal, are the most likely long-term survivors (LS). Other factors which appeared to be related to longer survival were younger age and high Karnofsky scores.
authors.affiliation: Department of Neurological Sciences, University of Rome La Sapienza, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Puzzilli
authors.forename: A
authors.initials: A
authors.lastname: Ruggeri
authors.forename: L
authors.initials: L
authors.lastname: Mastronardi
authors.forename: D
authors.initials: D
authors.lastname: Di Stefano
authors.forename: P
authors.initials: P
authors.lastname: Lunardi
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005909:Glioblastoma / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology; D017741:Survivors; D013702:Temporal Lobe / Q000473:pathology; D013997:Time Factors