title: Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns.
abstract: Chemical burns are slow healing injuries and their depth is difficult to assess. Tissue destruction continues as long as active material is present in the wound site. The routine therapy for treatment of full thickness chemical burns is early excision; it shortens hospitalization and reduces morbidity. However, presently there is no specific treatment for chemical burns of partial thickness. This study examined several treatment modalities for partial thickness chemical burns: surgical excision; laser ablation and chemical debridement with Debridase or trypsin-linked to gauze. Chemical burns were inflicted with nitrogen mustard (NM -- a nitrogen analog to sulfur mustard -- mustard gas) in an experimental guinea pig model. Debridase was most effective and reduced significantly lesion area of burns after 'humid' exposure to 2 mg NM. The healing action of Debridase was also evident in the significantly higher histopathological score of biopsies from local tissue obtained on day 5. Laser ablation was most effective and accelerated healing of burn lesions after 'dry' exposure to 5 mg NM. The histopathology score of the laser treated burns was higher on day 4 compared to untreated controls. It is concluded that for partial thickness chemical burns early nonsurgical removal of the damaged tissues accelerates wound healing.
authors.affiliation: The Department of Plastic Surgery, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Eldad
authors.forename: A
authors.initials: A
authors.lastname: Weinberg
authors.forename: S
authors.initials: S
authors.lastname: Breiterman
authors.forename: M
authors.initials: M
authors.lastname: Chaouat
authors.forename: D
authors.initials: D
authors.lastname: Palanker
authors.forename: H
authors.initials: H
authors.lastname: Ben-Bassat
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity; D001458:Bandages; D002057:Burns, Chemical / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D003646:Debridement / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006168:Guinea Pigs; D017075:Laser Coagulation; D008466:Mechlorethamine / Q000633:toxicity; D009583:Nitrofurazone / Q000008:administration & dosage / Q000627:therapeutic use; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D014357:Trypsin / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing
chemical_list: D000891:Anti-Infective Agents, Local; D018906:Antineoplastic Agents, Alkylating; D008466:Mechlorethamine; D014357:Trypsin; D009583:Nitrofurazone