POEMS syndrome with vascular lesions and renal carcinoma - possible role of cytokines.
We describe here the case of a 60 years man with POEMS syndrome associated with renal tumor and vascular lesions. The patient had osteosclerotic myeloma IgA-lambda, polyneuropathy, endocrinopathy and skin changes. In addition, he developed renal clear cell carcinoma and gangrena of lower limbs. The humoral study showed thrombocytosis, high levels of IL-1beta and IL-6 and of some coagulative/fibrinolytic and endothelial factors (von Willebrand factor, plasmin-antiplasmine complexes, plasminogen activator). We suggest the hypothesis that these factors are capable of determining some manifestations of POEMS syndrome.
Pasqui
A L
AL
U.O. Immunologia Clinica, Policlinico Le Scotte , I-53100 Siena, Italy. defranco@unisi.it
Bova
G
G
Saletti
M
M
Bruni
F
F
Di Renzo
M
M
Auteri
A
A
D018262:Adenocarcinoma, Clear Cell / Q000150:complications / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007680:Kidney Neoplasms / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016878:POEMS Syndrome / Q000150:complications / Q000276:immunology*; D010960:Plasminogen Activators / Q000097:blood; D014657:Vasculitis / Q000150:complications / Q000276:immunology*; D014841:von Willebrand Factor / Q000378:metabolism
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014841:von Willebrand Factor; D010960:Plasminogen Activators