[Botulinum toxin: mechanism of action].
Inhibitory effect of botulinum toxin on acetylcholine release from the neurons of peripheral nervous system and morphological changes produced in neuro-muscular junction by administration of the toxin are discussed. Other possible mechanisms of action, which can be responsible for the therapeutic effect are presented. Two clinically important problems are discussed: spreading of the toxin from the site of injection, and immunization which is responsible for non-responsiveness in some cases.
Bogucki
A
A
Oddziału Neurologii, Szpitala im. dr K. Jonschera w Lodzi.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D001905:Botulinum Toxins / Q000276:immunology / Q000494:pharmacology*; D006801:Humans; D009465:Neuromuscular Agents / Q000276:immunology / Q000494:pharmacology*; D017933:Peripheral Nervous System / Q000187:drug effects
D009465:Neuromuscular Agents; D001905:Botulinum Toxins; D000109:Acetylcholine
Toksyna botulinowa: mechanizm działania.