title: New insights into the regulation of megakaryocyte differentiation and platelet production derived from cloning of thrombopoietin and its receptor: surprises and unresolved questions as thrombopoietin proceeds through clinical trials.
authors.forename: C W
authors.initials: CW
authors.lastname: Jackson
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D003001:Cloning, Molecular; D004195:Disease Models, Animal; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D008533:Megakaryocytes / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; D011994:Recombinant Proteins / Q000378:metabolism; D013921:Thrombocytopenia / Q000503:physiopathology; D013922:Thrombocytosis / Q000503:physiopathology; D013926:Thrombopoietin / Q000502:physiology*
chemical_list: D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; D011994:Recombinant Proteins; C082218:MPL protein, human; D013926:Thrombopoietin