[Localization of the synthesis and transport of phospholipids in myelination in the central nervous system].
The phospholipids constitute a larger percentage of the myelin lipids. In the present cytochemical and electronmicroscopic studies we traced the appearance of phospholipids in morphological demonstrable form during the different periods of myelination in the brain of rabbits (from birth to adulthood). Phospholipids are detected in the oligodendrocytes situated along the nerve fibres prior and at very beginning of myelination and the neurons during active myelination. After completion of myelination no phospholipids could be demonstrated morphologically in these cells. The morphological demonstration of phospholipids in the oligodendrocytes and neurons during myelination is a manifestation of their increased synthesis. We expressed for the first time the view on the existence of neuroglial cooperation in the synthesis of myelin phospholipids, subsequently confirmed by the studies of axonal lipid transport.
Zaprianova
E T
ET
Laboratory of Myelinogenesis, Bulgarian Academy of Sciences, Sofia.
Deleva
D D
DD
D000818:Animals; D001692:Biological Transport; D002490:Central Nervous System / Q000378:metabolism*; D008854:Microscopy, Electron; D009413:Nerve Fibers, Myelinated / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D009836:Oligodendroglia / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis* / Q000493:pharmacokinetics; D011817:Rabbits
D010743:Phospholipids
Lokalizatsiia sinteza i transport fosfolipidov pri mielinizatsii v tsentral'noĭ nervnoĭ sisteme.