[Structural features of the rat adrenal cortex with inherited stress-induced arterial hypertension in the early period of postnatal ontogenesis].
Comparative morphometric examination of adrenal cortex was carried out in 3 wks HNCAI rats with inherited stress induced arterial hypertension and normotensive Wistar rats. Relative adrenal mass, volume of cortex and its glomerular zone in HNCAI rats exceeds appropriate values in Wistar rats. Increase of adrenocorticocytes due to hyperplasia of their ultrastructural components was found. In hypertensive rats adrenocorticocyte numerical density increase due to their hyperplasia was found in adrenal fasciculate zone in contrast to glomerular one. These structural organization peculiarities in 3 wks hypertensive rat adrenal cortex reflect their elevated functional activity and may determine genetically programmed increased organism responsiveness to stress that consequently provides the grounds for the hypertensive status formation in this rat line.
Buzueva
I I
II
Laboratory of Electron Microscopy, Siberian Section of Russian Academy of Medical Sciences, Novosibirsk.
Shmerling
M D
MD
Filiushina
E E
EE
Markel'
A L
AL
Iakobson
G S
GS
D000302:Adrenal Cortex / Q000254:growth & development / Q000473:pathology*; D000312:Adrenal Hyperplasia, Congenital / Q000473:pathology; D000818:Animals; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013045:Species Specificity; D013312:Stress, Physiological / Q000473:pathology*
Strukturnye osobennosti kory nadpochechnika krys s nasledstvennoĭ indutsirovannoĭ stressom arterial'noĭ gipertensieĭ v rannem periode postnatal'nogo ontogeneza.