The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease.
The importance of apolipoproteins in the central nervous system became increasingly clear with the association in 1993 of the epsilon4 allele of apolipoprotein E with familial and sporadic late-onset Alzheimer's disease. Apolipoprotein E is a ligand for several receptors, most of which are found to some extent in the brain. This review summarizes the various apolipoproteins and lipoprotein receptors found in the brain. A growing body of evidence now implicates irregular lipoprotein metabolism in several neurodegenerative disorders. We then focus on research linking apolipoprotein E and Alzheimer's disease, from clinical studies to biochemical models, which may explain some of the complex neurobiology of this disorder.
Beffert
U
U
Department of Neurology and Neurosurgery, McGill University, Montreal, PQ, Canada.
Danik
M
M
Krzywkowski
P
P
Ramassamy
C
C
Berrada
F
F
Poirier
J
J
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D053327:Apolipoprotein E4; D001053:Apolipoproteins / Q000378:metabolism*; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D001253:Astrocytes / Q000502:physiology; D001921:Brain / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009474:Neurons / Q000502:physiology; D011110:Polymorphism, Genetic; D018110:Receptors, Lipoprotein / Q000378:metabolism*
D053327:Apolipoprotein E4; D001053:Apolipoproteins; D001057:Apolipoproteins E; D018110:Receptors, Lipoprotein