Calcium crystal-associated arthritides.
Articular calcium-containing crystals cause calcium pyrophosphate dihydrate (CPPD) deposition disease, basic calcium phosphate (BCP)-associated syndromes, and calcium oxalate arthritis. During the past year, important contributions have been made to our understanding of CPPD- and BCP-related syndromes. Clinical studies of CPPD deposition disease underscore the importance of extra-articular and spinal CPPD deposits, and question the association between hypothyroidism and chondrocalcinosis. Laboratory reports add key information to our current paradigms of CPPD crystal formation and CPPD-induced inflammation. Several interesting new therapeutic interventions may arise from this work. A case collection of BCP-related syndromes emphasizes the need for considering this diagnosis in young healthy patients with acute arthritis or periarthritis.
Rosenthal
A K
AK
Rheumatology Section, Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295-1000, USA.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002131:Calcium Pyrophosphate / Q000737:chemistry / Q000378:metabolism; D002805:Chondrocalcinosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003460:Crystallization; D006073:Gout / Q000209:etiology; D006801:Humans; D010003:Osteoarthritis / Q000209:etiology; D013577:Syndrome
D000305:Adrenal Cortex Hormones; D002131:Calcium Pyrophosphate