HLA antigen profile in pulmonary tuberculosis patients & their spouses.
HLA-A, -B, -DR and -DQ antigen profile was studied in pulmonary tuberculosis patients (n = 209) and their spouses (family contacts; n = 50) and healthy volunteers (n = 72). An increased frequency of HLA-A-10, B7, B15, DR2 and DQ1 was seen in the pulmonary-TB (PTB) patients when compared to the total control subjects (n = 122). However, a significant increase was seen only with HLA-DR2 (P < 0.001; Pc < 0.01; Relative Risk 2.3) and -DQ1 (P < 0.005; Pc < 0.015; Relative Risk 2.8). Among the spouses and the corresponding patients, a similar increase of HLA-DR2 was seen. A decreased frequency of HLA-A19, B8, B17, B35, DR5 and DR6 were seen in PTB as compared to control groups. The present study suggested that HLA-DR2 and DQ1 genes/gene products may be associated with the susceptibility to tuberculosis either alone or in combination with other HLA or non-HLA genes.
Selvaraj
P
P
Tuberculosis Research Centre, Chennai.
Uma
H
H
Reetha
A M
AM
Kurian
S M
SM
Xavier
T
T
Prabhakar
R
R
Narayanan
P R
PR
D000328:Adult; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis / Q000235:genetics; D015802:HLA-DR2 Antigen / Q000032:analysis / Q000235:genetics; D006801:Humans; D008297:Male; D018454:Spouses; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D006680:HLA Antigens; D006683:HLA-DQ Antigens; C051568:HLA-DQ1 antigen; D015802:HLA-DR2 Antigen