title: Chromosome breaks and sister chromatid exchange as predictors of second cancers in Hodgkin's disease.
abstract: Hodgkin's disease (HD) survivors face an increased risk of developing second cancers. We evaluated baseline cytogenetic biomarkers, sister chromatid exchange (SCE) and chromosome breaks [spontaneous (SCB) and bleomycin-induced (BIB)], as predictors of second cancer risk in a cohort of 105 adult HD patients. During follow-up, seven second cancers occurred. SCBs and BIBs showed no association with risk of second primaries. Multivariate Cox regression revealed that high levels of SCEs (relative risk (RR)=11.3, p=0.02) and age (RR=1.08, p=0.02) predicted second cancer risk. Histology, stage, and treatment were not associated with elevated risk. In conclusion, baseline SCE frequencies may be a useful biomarker for identifying HD patients at increased risk of developing second cancers. These results need to be verified in a larger cohort with a longer follow-up time.
authors.affiliation: Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Strom
authors.forename: Y
authors.initials: Y
authors.lastname: Gu
authors.forename: A J
authors.initials: AJ
authors.lastname: Sigurdson
authors.forename: N M
authors.initials: NM
authors.lastname: Bailey
authors.forename: C I
authors.initials: CI
authors.lastname: Amos
authors.forename: M R
authors.initials: MR
authors.lastname: Spitz
authors.forename: M A
authors.initials: MA
authors.lastname: Rodriguez
authors.forename: J C
authors.initials: JC
authors.lastname: Liang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019457:Chromosome Breakage; D002877:Chromosomes, Human; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics* / Q000473:pathology*; D011237:Predictive Value of Tests; D012854:Sister Chromatid Exchange