Dysregulation of apoptosis as a mechanism of liver disease: an overview.
Apoptosis is a morphologically distinct form of cell death which occurs in a wide variety of liver diseases. In this overview chapter, we review: (1) the current definitions of apoptosis; (2) the biochemical pathways effecting apoptosis; and (3) the intracellular pathways regulating apoptosis. We also describe how apoptosis is identified in the liver and review the ligand/receptor interactions which trigger hepatobiliary apoptosis. Finally, we speculate on potential therapeutic applications for modulating apoptosis in human liver diseases. This information is meant to provide a foundation for the following chapters each focused on a specific role of apoptosis in liver diseases.
Patel
T
T
Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA.
Roberts
L R
LR
Jones
B A
BA
Gores
G J
GJ
D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D008107:Liver Diseases / Q000473:pathology* / Q000628:therapy