[Interactions of inhibitor of free radical reactions and 2-deoxyribosyl macroradicals].
By steric computer modelling of five types of 2-deoxyribosyl radicals and their molecular products generated in DNA by radiation as a result of R + InH = RH + In reaction the displacement of DNA bases (maximum--for C'1 atoms and minimum for C'3 ones) has been determined. Literature data on the DNA decay in the irradiated cells, and in DNA frozen solutions as well as the data on radiolysis of compounds modelling separate DNA fragments allowed to offer a general scheme of the every 2-deoxyribosyl radical transformation and to calculate a balance between the intermediate and final molecular products (processes) of the 2-deoxyribosyl radiolysis. The DNA conformation change due to the 2-deoxyribosyl stereoisomers formation at C'3 and C'4 atoms is discussed as one of the suggested reasons for genetic radiation mutation.
Kuzurman
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PA
N.M. Emanuel Institute of Biochemical Physics Russian Academy of Sciences, Moscow.
Sharpatyĭ
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VA
D000225:Adenine; D003198:Computer Simulation; D003596:Cytosine; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000528:radiation effects*; D018736:DNA Adducts; D004249:DNA Damage / Q000235:genetics; D053938:DNA Fragmentation; D004260:DNA Repair / Q000235:genetics; D003855:Deoxyribose / Q000737:chemistry / Q000528:radiation effects*; D005609:Free Radicals / Q000037:antagonists & inhibitors; D006147:Guanine; D017665:Hydroxyl Radical; D046911:Macromolecular Substances; D008956:Models, Chemical; D009154:Mutation; D011854:Radiochemistry; D013237:Stereoisomerism; D013941:Thymine
D018736:DNA Adducts; D005609:Free Radicals; D046911:Macromolecular Substances; D017665:Hydroxyl Radical; D003855:Deoxyribose; D006147:Guanine; D003596:Cytosine; D004247:DNA; D000225:Adenine; D013941:Thymine
O vzaimodeĭstvii veshchestva-ingibitora svobodnoradikal'nykh reaktsiĭ s makroradikalami 2-dezoksiribozila.