title: [Adverse effects of sunlight on the skin].
abstract: Many people consider a summer's day pleasant: warm and bright. The sun's ultraviolet rays do not contribute to the pleasure, and are biologically mainly harmful. As UV radiation does not penetrate any deeper than our skin, this organ has to be particularly well adapted to the UV exposure. The skin exploits the UV radiation for the synthesis of vitamin D3. Our day-to-day exposure suffices for this beneficial UV effect. Excessive exposure, as in sunbathing, only contributes to the adverse effects, like sunburn and suppression of cellular immunity in the short term, and 'photoaging' and skin cancer in the long term. The UVB radiation in sunlight is mainly responsible for these harmful effects, the UVA radiation to a far lesser extent (10-20% contribution). The UVA radiation from modern tanning equipment does not differ from that in sunlight, but UVA radiation does not lead to vitamin D3 production; it rather degrades vitamin D3 and a tan offers insufficient protection against the UVB radiation in full sunlight.
authors.affiliation: Academisch Ziekenhuis, afd. Dermatologic/Allergologie, Utrecht.
authors.forename: F R
authors.initials: FR
authors.lastname: de Gruijl
mesh_terms: D002762:Cholecalciferol / Q000096:biosynthesis; D006801:Humans; D012867:Skin / Q000276:immunology / Q000378:metabolism; D012871:Skin Diseases / Q000209:etiology*; D012878:Skin Neoplasms / Q000209:etiology; D013472:Sunlight / Q000009:adverse effects*; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D002762:Cholecalciferol
vernacular_title: Nadelige effecten van zonlicht op de huid.