Glucocorticoids alter recovery processes in the rat retina.
The effect of glucocorticoids on the electroretinogram (ERG) b-wave was studied in freely moving rats. b-Waves were evoked by flashes delivered by a light emitting diode implanted under the skin above the left eye. I.v. corticosterone and dexamethasone injection induced a transient increase in b-wave amplitude at 90 min. Retinal oscillatory potentials (OPs) were similarly enhanced. Pretreatment with a glucocorticoid receptor antagonist (RU 38486) abolished both increases. These results suggest that enhancements in retinal potentials may be the result of a glucocorticoid-induced facilitation of the processes under way in normal Müller cells following retinal excitation.
Abrahám
I
I
Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, Hungary.
Pálhalmi
J
J
Szilágyi
N
N
Juhász
G
G
D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D004596:Electroretinography / Q000187:drug effects*; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D015735:Mifepristone / Q000494:pharmacology; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology; D010775:Photic Stimulation; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D005938:Glucocorticoids; D015735:Mifepristone; D003907:Dexamethasone; D003345:Corticosterone