title: Improved cross peak detection in two-dimensional proton NMR spectra using excitation sculpting.
abstract: In two-dimensional homonuclear experiments, reliable detection of very small cross peaks is sometimes hampered by t1-noise from larger diagonal peaks which have the same F2 frequency. This t1-noise can be selectively removed by recording partial 2D spectra using the double pulsed field gradient spin echo (DPFGSE). Resonances not selected by the DPFGSE do not contribute any t1-noise to the resulting spectrum. The absence of t1-noise from the diagonal peaks render the small cross peaks at the same F2 frequency observable. The success of this technique is shown by partial 2D NOESY and TOCSY spectra.
authors.affiliation: Chemistry Department, University of California, Irvine 92697-2025, USA.
authors.forename: Q N
authors.initials: QN
authors.lastname: Van
authors.forename: A J
authors.initials: AJ
authors.lastname: Shaka
mesh_terms: D016477:Artifacts; D002247:Carbon Isotopes; D004578:Electron Spin Resonance Spectroscopy; D007089:Image Enhancement / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009587:Nitrogen Isotopes; D011522:Protons; D014364:Tryptophan / Q000032:analysis
chemical_list: D002247:Carbon Isotopes; D009587:Nitrogen Isotopes; D011522:Protons; D014364:Tryptophan