CD8-positive mantle cell lymphoma: a report of two cases.
Two cases of mantle cell lymphoma with a unique CD8+ phenotype are reported. Both patients had disease that was resistant to therapy; one patient had the blastic variant of mantle cell lymphoma. Flow cytometric analysis of bone marrow and cerebrospinal fluid samples revealed a phenotype consistent with mantle cell lymphoma, with the additional finding of CD8 positivity in 40% or more of the tumor cells in both cases. This is the first description of such a finding, and CD8+ mantle cell lymphoma may represent a unique type of B-cell neoplasia. Our findings may be important in the prediction of therapeutic response or in the detection of residual disease after therapy.
Hoffman
D G
DG
Department of Pathology, Center for the Health Sciences, University of California, Los Angeles 90095, USA.
Tucker
S J
SJ
Emmanoulides
C
C
Rosen
P A
PA
Naeim
F
F
D018951:Antigens, CD20 / Q000032:analysis; D001854:Bone Marrow Cells / Q000276:immunology; D017252:CD3 Complex / Q000032:analysis; D018956:CD5 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D006801:Humans; D016130:Immunophenotyping; D008228:Lymphoma, Non-Hodgkin / Q000134:cerebrospinal fluid / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000032:analysis
D018951:Antigens, CD20; D017252:CD3 Complex; D018956:CD5 Antigens; D016827:CD8 Antigens; D005456:Fluorescent Dyes; D017455:Receptors, IgE; D016650:Fluorescein-5-isothiocyanate