[Transgenic mice in basic research].
What are transgenic mice and what do we learn from them? In this review, we focus on the generation of "classical" transgenic and "knock-out" mice. The establishment of transgenic and gene-targeted mice provides an unique tool to study the function(s) of a given gene in the context of a whole organism. Based on selected examples, we demonstrate the potential of this transgenic technology to understand the interactions between cells, organs and organ systems in genetically engineered mice.
Gassmann
M
M
Physiologisches Institut, Universität Zürich.
Hennet
T
T
Bauer
C
C
D000544:Alzheimer Disease / Q000209:etiology; D000818:Animals; D002543:Cerebral Hemorrhage / Q000517:prevention & control; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D010641:Phenotype; D012107:Research Design; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
D014409:Tumor Necrosis Factor-alpha
Transgene Mäuse in der Grundlagenforschung.