[Euthyroid goiter with and without functional autonomy in the euthyroid phase: a comparison].
OBJECTIVE
Analysis of functional autonomy in euthyroid goitre.


METHODS
In an area of moderate iodine deficiency 163 goitrous patients without and 179 with functional autonomy all clinically euthyroid were compared by sex, age, signs and symptoms, sonographic results, qualitative and quantitative scintigraphy without and with suppression, TRH test, hormone concentrations and iodine excretion in the urine.


RESULTS
Age, signs and symptoms, thyroid volume and structure did not contribute sufficiently to diagnosis. To detect functional autonomy quantitative scintigraphy under suppression was superior to the TRH test. Increased hormone concentrations were observed in 15% of patients with functional autonomy. A global 99mTc thyroid uptake of > or = 3% under suppression indicates a higher risk of spontaneous hyperthyroidism. It was present in 20% of patients with functional autonomy.


CONCLUSIONS
To diagnose and treat adaequately functional autonomy in euthyroid goitre quantitative scintigraphy, determination of TSH and hormone concentrations are inevitable.
Hillenhinrichs
H
H
Nuklearmedizinischen Abteilung, Klinikum der Universität Göttingen, Deutschland.
Emrich
D
D
D005260:Female; D006042:Goiter / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007455:Iodine / Q000378:metabolism; D008297:Male; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012727:Sex Characteristics; D013667:Technetium; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013667:Technetium; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine
Jodmangelstruma mit und ohne funktionelle Autonomie in der euthyreoten Phase: Ein Vergleich.