Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists.
Yang
L
L
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
Guo
L
L
Pasternak
A
A
Mosley
R
R
Rohrer
S
S
Birzin
E
E
Foor
F
F
Cheng
K
K
Schaeffer
J
J
Patchett
A A
AA
D000818:Animals; D016466:CHO Cells; D002460:Cell Line; D006224:Cricetinae; D000242:Cyclic AMP / Q000819:agonists; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D051379:Mice; D008958:Models, Molecular; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017481:Receptors, Somatostatin / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship
D007211:Indoles; C112853:L 54264; D008024:Ligands; D010880:Piperidines; D017481:Receptors, Somatostatin; D013006:Growth Hormone; C093733:somatostatin receptor 2; D000242:Cyclic AMP