title: Plasma pharmacokinetics of a generic amoxycillin and the innovator brand: a comparison.
abstract: OBJECTIVE
  To compare the bioavailability and plasma pharmacokinetics of a generic brand of amoxycillin (State Pharmaceutical Manufacturing Coporation) selected from the lower price range, with that of the innovation brand (Amoxil, Beecham).
  
  
  METHODS
  Sixteen healthy adult volunteers were allotted to two groups and each group was given a test dose of amoxycillin from each brand. Blood samples were collected at 0, 2, 3 and 4 hours thereafter plasma levels were assayed using high performance liquid chromatography.
  
  
  RESULTS
  Analysis of results show that the generic product had similar bioavailability and pharmacokinetics when compared with the innovator product.
  
  
  CONCLUSIONS
  The quality assured generic amoxycillin tested had similar bioavailability as a more costly branded version.
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Sri Jayewardenepura.
authors.forename: A K
authors.initials: AK
authors.lastname: Goonetilleke
authors.forename: J M
authors.initials: JM
authors.lastname: Munasingha
authors.forename: D S
authors.initials: DS
authors.lastname: Guruge
authors.forename: D S
authors.initials: DS
authors.lastname: Samaraweera
authors.forename: O V
authors.initials: OV
authors.lastname: Weerasena
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D016568:Drugs, Generic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D010406:Penicillins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012016:Reference Values
chemical_list: D016568:Drugs, Generic; D010406:Penicillins; D000658:Amoxicillin