title: Investigation of the metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in the rat.
abstract: The metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a compound with promising pharmacological effects against arrhythmia, was investigated in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR. The following metabolic pathway is proposed: CTHB is metabolized by demethylation at position 10 to produce a new entity.
authors.affiliation: China Pharmaceutical University, Nanjing, People's Republic of China.
authors.forename: N
authors.initials: N
authors.lastname: Feng
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: An
authors.forename: W
authors.initials: W
authors.lastname: Huang
authors.forename: G
authors.initials: G
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Han
authors.forename: X
authors.initials: X
authors.lastname: Bao
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000378:metabolism*; D001599:Berberine / Q000031:analogs & derivatives* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C113590:7-(4-chlorobenzyl)-7,8,13,13a-tetrahydroberberine; D000889:Anti-Arrhythmia Agents; D001599:Berberine