title: [Prognostic factors in breast cancer with contralateral supraclavicular or axillary lymphatic metastases].
abstract: OBJECTIVE
  To evaluate prognostic factor differences between surviving and decreased breast cancer patients in clinical stage IV with supraclavicular or contralateral axilla metastasis when first seen.
  
  
  METHODS
  From the clinical records of 13 years (1975-88) two groups of ten patients each were obtained. Group 1 were women alive and free of disease for more than five years. Group 2 had similar characteristics but had died of the disease. In both groups clinical data were evaluated (age, menstrual status and survival); from slides the histologic factors like tumor size, nodal status, fibrosis percentage, inflammatory infiltrate, nuclear grade and necrosis were evaluated; immunohistochemistry of CD34 for angiogenesis, cathepsin D, p53 antioncogen, c-erb-B2 oncogen, epidermic growth factor, estrogen and progesterone receptors and cellular kinetics were performed; Kaplan Meier survival curves were constructed for the factors showing intergroup differences.
  
  
  RESULTS
  The factors associated to the living patients were: low inflammatory infiltrate (p = 0.001), low fibrosis (p = 0.007), lower p53 expression (p = 0.03) and positive estrogen receptor (p = 0.03); other factors were marginally associated: positive progesterone receptor (p = 0.07) and having less than 6 positive lymph nodes (p = 0.07).
authors.affiliation: División Cirugía, Instituto Nacional de Cancerología, México, D.F., México.
authors.forename: D
authors.initials: D
authors.lastname: Muñoz-González
authors.forename: A
authors.initials: A
authors.lastname: Mora-Tizcareño
authors.forename: M T
authors.initials: MT
authors.lastname: Ramírez-Ugalde
authors.forename: M
authors.initials: M
authors.lastname: Pérez-Sánchez
authors.forename: E
authors.initials: E
authors.lastname: Sánchez-Valdivieso
authors.forename: C
authors.initials: C
authors.lastname: Gómez-Ruiz
authors.forename: I
authors.initials: I
authors.lastname: Zeichner-Gancz
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D005355:Fibrosis; D006801:Humans; D007249:Inflammation; D015993:Life Tables; D008207:Lymphatic Metastasis; D008593:Menopause; D008875:Middle Aged; D009333:Neck; D009336:Necrosis; D009363:Neoplasm Proteins / Q000032:analysis; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
vernacular_title: Factores pronósticos en cáncer de mama con metástasis a ganglios supraclaviculares o axila contralateral.