title: Microsatellite instability in adult T-cell leukaemia.
abstract: Microsatellite instability (MSI) is thought to represent a defect of the DNA mismatch repair system which has been implicated in the tumourigenesis of several human malignancies. We investigated MSI in acute/ lymphomatous adult T-cell leukaemia (ATL: n=22) using 54 highly polymorphic dinucleotide short-tandem repeat sequences. The corresponding control DNA from each individual was obtained from the peripheral blood in either chronic phase (n=5) or when complete remission was achieved (n=17). 10/22 (41%) patients had MSI, six of whom showed MSI in multiple loci; four loci had MSI in multiple samples. The incidence of MSI in ATL was found to be higher than in other haematological malignancies, indicating MSI as a feature of ATL, which may be involved in the progression of the disease.
authors.affiliation: Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Hatta
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Tomonaga
authors.forename: I
authors.initials: I
authors.lastname: Miyoshi
authors.forename: J W
authors.initials: JW
authors.lastname: Said
authors.forename: H P
authors.initials: HP
authors.lastname: Koeffler
mesh_terms: D006801:Humans; D015458:Leukemia, T-Cell / Q000235:genetics*; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction