title: Prospective evaluation of the utilization of aspirin and non-steroidal anti-inflammatory drugs in acute medical admissions.
abstract: The aim of this study was to analyse the frequency of aspirin and NSAID usage in 400 unselected patients admitted to the general medical wards through the Accident and Emergency Department. One hundred and twenty patients (30%) reported using NSAIDs (n = 27) or aspirin (n = 99) prior to admission. The median age was 70.5 years (IQR 54-80). Most aspirin use was low dose for cardiovascular prophylaxis and headache. The reported indications for NSAID use were osteoarthritis (n = 12), rheumatoid arthritis (n = 9), gout (n = 3) and psoriatic arthritis (n = 2) and headache (n = 1). Only 23 (19%) patients were aware of the potential side effects of these agents. Co-prescribing with an H2 antagonist (n = 10), proton pump inhibitor (n = 11) or misoprostol (n = 5) was noted in 21.6%. Approximately one third of patients admitted to general medical wards in this study were receiving NSAIDs or Aspirin. The indications for prescribing were appropriate for aspirin. NSAID use was more symptom based and may have been better managed using an analgesic in some cases. Despite the high prevalence of upper gastrointestinal symptoms, co-prescribing of ulcer healing drugs was relatively uncommon.
authors.affiliation: Department of Gastroenterology, Beaumont Hospital, Dublin.
authors.forename: S
authors.initials: S
authors.lastname: Pathmakanthan
authors.forename: D G
authors.initials: DG
authors.lastname: O'Donovan
authors.forename: K M
authors.initials: KM
authors.lastname: Sheehan
authors.forename: F E
authors.initials: FE
authors.lastname: Murray
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use*; D003327:Coronary Disease / Q000517:prevention & control; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004630:Emergencies; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy; D010343:Patient Admission / Q000706:statistics & numerical data; D011446:Prospective Studies
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D001241:Aspirin