Cyanonitrosylmetallates as potential NO-donors.
The [M(CN)xNOy]n- complexes (where M = Cr(I), Mn(I), Mn(II), Fe(I), Fe(II), Fe(III)) were studied as potential NO-donors using both pharmacological and theoretical semi-empirical methods. Only iron complexes appeared to be pharmacologically active. The quantum chemical calculations indicated that these complexes have the highest predisposition to undergo a nucleophilic attack followed by the NO+ release. The results allowed us to interpret the metabolism of the [M(CN)xNOy]n- complexes in terms of the NO(+)-donation.
Oszajca
J
J
Department of Inorganic Chemistry, Jagiellonian University, Kraków, Poland.
Stochel
G
G
Wasielewska
E
E
Stasicka
Z
Z
Gryglewski
R J
RJ
Jakubowski
A
A
Cieślik
K
K
D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D008956:Models, Chemical; D009569:Nitric Oxide / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D011817:Rabbits; D013696:Temperature; D014665:Vasodilator Agents / Q000494:pharmacology*
D009942:Organometallic Compounds; D014665:Vasodilator Agents; D009599:Nitroprusside; D009569:Nitric Oxide