title: Synthesis and biological evaluation of certain new thiazolopyrimidines.
abstract: A series of 5-methyl-3-phenyl thiazolo[5,4-e][1,2,4]triazolo[1,5-c] pyrimidin-2-thiones and 5-methyl-3-phenyl thiazolo[5,4-e]pyrimidino[3,4-b][1,2,4]triazin-2-thiones were prepared as potential antimicrobial and antitumor agents. Some of the tested compounds showed promising activity. The detailed synthesis, spectroscopic and biological data are reported.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Farmacy, University of Mansoura, Egypt.
authors.forename: E R
authors.initials: ER
authors.lastname: el-Bendary
authors.forename: M A
authors.initials: MA
authors.lastname: el-Sherbeny
authors.forename: F A
authors.initials: FA
authors.lastname: Badria
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000187:drug effects / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D011743:Pyrimidines; D013844:Thiazoles