[5-S-cysteinyldopa as a tumor marker for primary uveal malignant melanoma].
The clinical significance of 5-S-cysteinyldopa (5-S-CD), a major intermediate in melanin synthesis, was evaluated as a potential diagnostic tumor marker for uveal melanoma. Serum concentrations of 5-S-CD in 6 out of 7 patients with uveal melanoma in the absence of extraocular metastases were close to those of controls. In contrast, serum concentrations of 5-S-CD were found to be elevated in 3 patients with systemic metastases of melanoma. In addition, 5-S-CD in intraocular fluids, including both aqueous and vitreous humor, was elevated in patients with uveal melanoma regardless of the presence or absence of systemic metastases. These results suggest that 5-S-CD in the intraocular fluid may serve as a useful biochemical marker for the diagnosis of uveal melanoma.
Goto
H
H
Department of Ophthalmology, Tokyo Medical College, Japan.
Tenou
T
T
Kudo
H
H
Iwasaki
T
T
Muramatsu
R
R
Usui
M
M
Wakamatsu
K
K
Ito
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood*; D003548:Cysteinyldopa / Q000032:analysis / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis*; D008875:Middle Aged; D014604:Uveal Neoplasms / Q000175:diagnosis*; D014822:Vitreous Body / Q000737:chemistry
D014408:Biomarkers, Tumor; D003548:Cysteinyldopa