Physico-chemical properties and antioxidant activities of methoxy phenols.
A few structurally related phenols, dehydrozingerone (DZ), bromopentenone (BP), eugenol (EG) and isoeugenol (IEG), derived from plant products show antioxidant properties by inhibiting lipid peroxidation in membrane models. The phenoxyl radicals produced by the scavenging of free radicals during the inhibition of lipid peroxidation, were also generated by specific one-electron oxidants using pulse radiolysis. The radical lifetimes (second order rate constants for radical-radical reactions), reactivities with hydroxyl and model peroxyl radicals and the one-electron reduction potentials with respect to the standard couples were quantified. These results along with their lipophilicity data were correlated with their antioxidant activity (IC50 values).
Priyadarsini
K I
KI
Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India.
Guha
S N
SN
Rao
M N
MN
D000975:Antioxidants / Q000737:chemistry*; D001386:Azides / Q000737:chemistry; D005054:Eugenol / Q000031:analogs & derivatives / Q000737:chemistry; D016166:Free Radical Scavengers / Q000378:metabolism; D005609:Free Radicals / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D010422:Pentanones / Q000737:chemistry; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism; D011675:Pulse Radiolysis; D013053:Spectrophotometry; D013343:Styrenes / Q000737:chemistry
D000975:Antioxidants; D001386:Azides; D016166:Free Radical Scavengers; D005609:Free Radicals; D006842:Hydrocarbons, Brominated; D010422:Pentanones; D010636:Phenols; D013343:Styrenes; C042329:phenoxy radical; D017665:Hydroxyl Radical; D005054:Eugenol; C036643:isoeugenol; C052933:methyl-3-methoxy-4-hydroxystyryl ketone