title: Evaluation of antimicrobial efficacy and release pattern of tetracycline and metronidazole using a local delivery system.
abstract: The present study compared the effectiveness of two antimicrobials, tetracycline and metronidazole, in reducing subgingival microorganisms in periodontal pockets using an ethyl cellulose strip as the delivery medium. The study involved 30 patients, with a minimum of 3 periodontal pockets with probing depths > 6 mm throughout the oral cavity. Patients were given supragingival scaling and then divided into 5 groups, depending on the length of time the medication was in place. Sites were marked for tetracycline, metronidazole, and placebo. Sites were wiped and isolated, and baseline microbiology samples were taken for Gram staining and culture methods. After treatment, subgingival microbiological samples were taken again. The ethyl cellulose strips were removed and analyzed for any remaining drug. Results showed that tetracycline and metronidazole can both be applied locally to periodontal sites using ethyl cellulose strips and markedly suppress the subgingival bacteria over a period of several days. The tetracycline showed a faster release; however, the metronidazole required a lesser concentration to achieve complete reduction of the subgingival flora.
authors.affiliation: Department of Periodontics, A. B. Shetty Memorial Institute of Dental Sciences, Mangalore, India.
authors.forename: B V
authors.initials: BV
authors.lastname: Somayaji
authors.forename: U
authors.initials: U
authors.lastname: Jariwala
authors.forename: P
authors.initials: P
authors.lastname: Jayachandran
authors.forename: K
authors.initials: K
authors.lastname: Vidyalakshmi
authors.forename: R V
authors.initials: RV
authors.lastname: Dudhani
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D000994:Antitrichomonal Agents / Q000008:administration & dosage*; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D005260:Female; D006244:Hardness; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010514:Periodontal Pocket / Q000188:drug therapy* / Q000382:microbiology; D013752:Tetracycline / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D000994:Antitrichomonal Agents; D008795:Metronidazole; C013517:ethyl cellulose; D002482:Cellulose; D013752:Tetracycline