title: Pyoderma gangrenosum following cytosine arabinoside, aclarubicin and granulocyte colony-stimulating factor combination therapy in myelodysplastic syndrome.
abstract: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis, which may be associated with systemic conditions such as hematologic disorders. We present a patient who had been diagnosed as having myelodysplastic syndrome associated with PG at onset, in whom a febrile ulcerative skin lesion developed following cytosine arabinoside, aclarubicin and granulocyte colony-stimulating factor (G-CSF) combination chemotherapy in the course of the disease. Skin biopsy revealed dense neutrophilic infiltrate in the dermis with central epidermal ulceration, consistent with the diagnosis of PG. Oral prednisolone was effective for the skin lesion. In this case, G-CSF application may participate in the recurrence of PG.
authors.affiliation: Fifth Department of Internal Medicine, Tokyo Medical College Kasumigaura Hospital, Ibaraki.
authors.forename: S
authors.initials: S
authors.lastname: Takagi
authors.forename: A
authors.initials: A
authors.lastname: Ohsaka
authors.forename: H
authors.initials: H
authors.lastname: Taguchi
authors.forename: H
authors.initials: H
authors.lastname: Kusama
authors.forename: T
authors.initials: T
authors.lastname: Matsuoka
mesh_terms: D015250:Aclarubicin / Q000009:adverse effects*; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001706:Biopsy; D003561:Cytarabine / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D012008:Recurrence; D012867:Skin / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D005938:Glucocorticoids; D003561:Cytarabine; D016179:Granulocyte Colony-Stimulating Factor; D015250:Aclarubicin; D011239:Prednisolone