title: [Aggressive cutaneous T-cell lymphoma associated with the presence of Epstein-Barr virus. 2 cases].
abstract: BACKGROUND
  The factors of prognosis of the cutaneous T-cell lymphomas are less well known as those of the B-cell lymphomas and the role of the Epstein-Barr virus (EBV) is not yet definitively evaluated.
  
  
  METHODS
  Two male patients aged 62 and 82 years had a mycosis fungoides with a lethal outcome. The first patient had mutilating facial tumors; the RNA m of EBV and the genome of EBV were demonstrated in the diseased skin. The second patient had an erythrodermic course with enlarged peripheral lymph nodes and circulating Sézary's cells; the genome of EBV was demonstrated by PCR in the diseased skin.
  
  
  CONCLUSIONS
  The role of the EBV has already been demonstrated in peripheral aggressive T-cell lymphomas. In the mycosis fungoides, the EBV is associated with the lesions in 0 to 32 p. cent according to the published series. EBV associated T-cell lymphomas have a poor survival rate and the EBV infection may be associated with the expression of the multidrug resistant gene-1 (MDR-1) and the risk of a terminal hemophagocytosis. In our both patients the presence of the EBV in the lymphocytes of the skin lesions is also an argument in favour of the pathogenic role of the virus.
authors.affiliation: Service de Dermatologie, Hôpital Saint-Louis, Paris.
authors.forename: F
authors.initials: F
authors.lastname: Mouly
authors.forename: M
authors.initials: M
authors.lastname: Baccard
authors.forename: M
authors.initials: M
authors.lastname: Rybojad
authors.forename: C
authors.initials: C
authors.lastname: Lebbé
authors.forename: F
authors.initials: F
authors.lastname: Morinet
authors.forename: P
authors.initials: P
authors.lastname: Morel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005153:Facial Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D017809:Fatal Outcome; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy
vernacular_title: Lymphome T cutané agressif associé à la présence de virus Epstein-Barr. Deux cas.