title: Pediatric central nervous system tumors.
abstract: Much of the recent change in the management of brain tumors in children has centered on the expanded use of chemotherapy. The addition of chemotherapy has resulted in better survival rates for children with medulloblastoma and altered the management for those with low-grade gliomas. For other tumor types, therapeutic advances have been slower. High-dose chemotherapy increasingly is being employed to treat malignant childhood tumors, with variable results.
authors.affiliation: Children's Hospital of Alabama, Division of Pediatric Neurology, University of Alabama, Birmingham 35233, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Reddy
authors.forename: R J
authors.initials: RJ
authors.lastname: Packer
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003952:Diagnostic Imaging; D004806:Ependymoma / Q000401:mortality / Q000473:pathology / Q000628:therapy; D005910:Glioma / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D007223:Infant; D008527:Medulloblastoma / Q000401:mortality / Q000473:pathology / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000628:therapy; D018365:Neoplasm, Residual; D009373:Neoplasms, Germ Cell and Embryonal / Q000401:mortality / Q000473:pathology / Q000628:therapy; D012074:Remission Induction; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome