title: Chronic abruption-oligohydramnios sequence.
abstract: OBJECTIVE
  To determine outcome in patients with chronic abruption.
  
  
  METHODS
  A retrospective review was performed of all patients delivering at a tertiary medical center during a 54-month period. All patients with a diagnosis of placental abruption with oligohydramnios or ruptured membranes were included. Chronic abruption-oligohydramnios sequence (CAOS) was defined by the following criteria: (1) clinically significant vaginal bleeding in the absence of placenta previa or other identifiable source of bleeding, (2) amniotic fluid volume initially documented as normal, and (3) oligohydramnios (amniotic fluid index < or = 5) eventually developing without concurrent evidence of ruptured membranes.
  
  
  RESULTS
  Twenty-four patients with CAOS were identified. Fourteen had first evidence of abruption at < 20 weeks' gestational age. A clot was identified between the chorion and uterus in 18/24. The mean gestational age at the first bleeding episode was 19.4 +/- 5.5 (SD) weeks, with the mean gestational age at delivery 28.1 +/- 4.5 weeks. Preterm premature membrane rupture occurred in 15/24. In these 15 there was a mean of 11.5 +/- days between the diagnosis of oligohydramnios and of ruptured membranes. Patients whose first blood occurred at < 20 weeks' gestation delivered at a gestational age of 26.1 +/- 3.9 weeks versus 33.0 +/- 5.3 weeks for the control group.
  
  
  CONCLUSIONS
  CAOS can occur in pregnancies complicated by abruptio placentae. If it develops, the mean gestational age at delivery is 28 weeks.
authors.affiliation: Phoenix Perinatal Associates, Arizona, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Elliott
authors.forename: B
authors.initials: B
authors.lastname: Gilpin
authors.forename: T H
authors.initials: TH
authors.lastname: Strong
authors.forename: H J
authors.initials: HJ
authors.lastname: Finberg
mesh_terms: D000037:Abruptio Placentae / Q000150:complications*; D000328:Adult; D002821:Chorioamnionitis / Q000209:etiology; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005322:Premature Rupture of Fetal Membranes / Q000150:complications; D005865:Gestational Age; D006801:Humans; D016104:Oligohydramnios / Q000150:complications*; D011247:Pregnancy; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins