title: Zinc status relates to hematological deficits in middle-aged women.
abstract: OBJECTIVE
  The objective of our study was to investigate zinc (Zn) status and the effects of Zn supplementation in relation to iron deficiency anemia in middle-aged women. It is important to define the role of Zn in hematologic abnormalities and to determine the frequency of Zn deficiency.
  
  
  METHODS
  Fifty-two Japanese women, selected from a health examination survey on 6200 women, had hemoglobin concentrations below 12.0 g/dl, total iron binding capacity (TIBC) below 390 micrograms/dl and fairly normocytemia. These 52 were divided into three groups and we then compared the hematological status before and after iron (group A) or Zn (group B) or iron plus Zn (group C) supplementation.
  
  
  RESULTS
  After treatment, concentrations of hemoglobin (Hb) increased slightly in groups A and B, but not statistically significant. In group C, Hb levels were significantly increased from 10.8 +/- 1.1 to 12.8 +/- 1.1 g/dl. Furthermore, numbers of RBC and reticulocytes, and concentrations of albumin were also increased significantly. Increased values over 1.0 g/dl of hemoglobin levels were noted in four women (26.6%) in group A, three women (14.2%) in group B and 13 women (81.2%) in group C.
  
  
  CONCLUSIONS
  Zn status to some extent can account for hematological abnormalities in middle-aged women. At least 5.0% of middle-aged Japanese women may have Zn deficiency. Normocytic anemia with low TIBC levels may serve as a good indicator of a marginal Zn deficiency.
authors.affiliation: Department of Pediatrics, Kumamoto University, School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nishiyama
authors.forename: K
authors.initials: K
authors.lastname: Irisa
authors.forename: T
authors.initials: T
authors.lastname: Matsubasa
authors.forename: A
authors.initials: A
authors.lastname: Higashi
authors.forename: I
authors.initials: I
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood*; D004909:Erythrocyte Indices; D005260:Female; D005293:Ferritins / Q000097:blood; D006402:Hematologic Diseases / Q000097:blood*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood; D008875:Middle Aged; D009752:Nutritional Status; D010758:Phosphorus / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism; D015032:Zinc / Q000008:administration & dosage / Q000097:blood*
chemical_list: D006454:Hemoglobins; D012709:Serum Albumin; D010758:Phosphorus; D005293:Ferritins; D007501:Iron; D015032:Zinc