title: Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall.
abstract: We investigated the morphological changes in the aorta due to reduced systemic pulse pressure in prolonged nonpulsatile left heart bypass (LHB). Nineteen adult goats were divided into 3 groups, the nonpulsatile group in which nonpulsatile LHB was conducted, the pulsatile group in which pulsatile LHB was conducted, and the control group used as the normal control. The average aortic pulse pressures were 12, 47, and 37 mm Hg, respectively. The descending aorta was subjected to morphological examination. In the nonpulsatile group, the wall was significantly thinner, and the volume ratio of smooth muscle cells (SMCs) was much lower. In terms of the SMC type classification, the proportion of SMCs with low activity and low contractility was higher, and the cell density of the SMCs was increased compared to those in the other groups. These results indicate that prolonged nonpulsatile LHB causes morphological atrophic changes in the aorta.
authors.affiliation: Department of Artificial Organs, National Cardiovascular Center Research Institute, Suita, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: S
authors.initials: S
authors.lastname: Takaichi
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: Y
authors.initials: Y
authors.lastname: Wakisaka
authors.forename: T
authors.initials: T
authors.lastname: Nakatani
authors.forename: T
authors.initials: T
authors.lastname: Masuzawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takewa
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: M
authors.initials: M
authors.lastname: Nakata
authors.forename: H
authors.initials: H
authors.lastname: Takano
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology* / Q000648:ultrastructure; D001783:Blood Flow Velocity / Q000502:physiology; D002417:Cattle; D002452:Cell Count; D002473:Cell Wall / Q000473:pathology / Q000648:ultrastructure; D018611:Heart Bypass, Left; D009119:Muscle Contraction / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology* / Q000648:ultrastructure; D011312:Pressure; D011673:Pulsatile Flow