title: [Multicenter clinical trial of the antitumor drug Dioxadet (phase II)].
abstract: A stage II of the joint clinical study of Dioxadet, an ethylene imine drug, was carried out to evaluate its therapeutic effect in 229 patients and side-effects in 239 patients with malignancies of various sites. Marked therapeutic effect was observed in ascitic malignancies of the ovary and a moderate one--in disseminated breast cancer. The most frequent side-effect was reversible myelodepression, often delayed.
authors.affiliation: Prof. N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
authors.forename: M L
authors.initials: ML
authors.lastname: Gershanovich
authors.forename: V A
authors.initials: VA
authors.lastname: Filov
authors.forename: D G
authors.initials: DG
authors.lastname: Kotova
authors.forename: A N
authors.initials: AN
authors.lastname: Stukov
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Sokolov
authors.forename: B A
authors.initials: BA
authors.lastname: Ivin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014227:Triazines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014227:Triazines; C040269:dioxadet
vernacular_title: Rezul'taty kooperirovannogo klinicheskogo izucheniia protivoopukholevogo preparata dioksadèt po II faze.