title: [MRI with supermagnetic iron particles versus double-spiral CT in identification of malignant liver lesions].
abstract: OBJECTIVE
  The purpose of this study was to evaluate the efficacy of MRI with superparamagnetic iron oxide (SPIO) and double-spiral CT in the detection of liver metastases and hepatocellular carcinoma.
  
  
  METHODS
  38 patients with a total of 144 malignant hepatic lesions underwent CT and MRI. A panel of experts defined the gold standard. Five experienced judges performed independently blinded evaluation of the number of detectable lesions. Multifactorial variance analysis was used to determine the statistical significance.
  
  
  RESULTS
  SPIO-MRI shows the highest rate of detection and is significantly superior to native MRI and native CT. The highest rate of detection by CT is shown in the portal-venous phase of contrast; nevertheless, the rate is significantly inferior to SPIO-MRI. In general, the native phases of CT and MRI are significantly inferior to the contrast phases of both. SPIO-MRI shows a higher rate of false positive findings.
  
  
  CONCLUSIONS
  The time-consuming and cost-intensive SPIO-MRI significantly increases the rate of detectability for malignant liver lesions compared with double-spiral CT but it also increases the rate of false positive findings.
authors.affiliation: Zentralinstitut für Röntgendiagnostik, Universitätsklinikum Essen.
authors.forename: R D
authors.initials: RD
authors.lastname: Müller
authors.forename: K
authors.initials: K
authors.lastname: Vogel
authors.forename: K
authors.initials: K
authors.lastname: Neumann
authors.forename: H
authors.initials: H
authors.lastname: Hirche
authors.forename: J
authors.initials: J
authors.lastname: Barkhausen
authors.forename: F
authors.initials: F
authors.lastname: Stöblen
authors.forename: H
authors.initials: H
authors.lastname: Henrich
authors.forename: R
authors.initials: R
authors.lastname: Langer
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D003365:Costs and Cost Analysis; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005290:Ferric Compounds; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000191:economics / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000191:economics / Q000379:methods*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide
vernacular_title: MRT mit superparamagnetischen Eisenpartikeln versus Doppelspiral-CT beim Nachweis maligner Leberläsionen.