Impaired early visual processing in disorganised schizophrenia.
Topographic differences in flash/pattern shift VEP data are evaluated in paranoid (n: 38), disorganized (n: 23) and residual (n: 23) schizophrenic subtypes and compared to normal controls. Increased early P1 and a restricted diffusion of the late P2 responses suggest dopaminergic over- and cholinergic underactivity in paranoid and residual schizophrenia. A distinctive pattern N145 reflects well-preserved attentional resources in the paranoid subtype. Latency increase and amplitude decrease of the pattern N145 concur with abnormal antisaccades documented in disorganized behaviour. VEP-data might help differentiate between schizophrenic subtypes.
Van Sweden
B
B
Department of Clinical Neurophysiology, Medical Centre St-Jozef, Bilzen, Belgium.
Van Erp
M G
MG
Mesotten
F
F
Crevits
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D008606:Mental Processes / Q000502:physiology*; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*