title: Myocardial iron deposition in beta-thalassemia studied by magnetic resonance imaging.
abstract: Myocardial iron deposition is a common finding in beta-thalassemia. The iron content of the myocardium was assessed using the T2 relaxation time of the heart. The T2 relaxation time of the liver and skeletal muscle was also assessed in order to study the relation of iron deposition between heart, liver and skeletal muscle. ECG gated spin echo images were obtained from thirty-eight consecutive adult thalassemic patients examined in an outpatient clinic, aged (x +/- SD) 25 +/- 6 years, using a 0.5 T system. Patients were divided into groups A and B, according to their average serum ferritin levels of the preceding five years (> or < 2000 ng/ml). Results were compared with nine controls, aged 24 +/- 7 years. Heart T2 relaxation time in the control group (x +/- SD) (48.3 +/- 5.5 msec) was higher compared to group A (28.4 +/- 6.7 msec, p < 0.001) but not to group B (43.4 +/- 7.4 msec). The T2 relaxation time of the heart correlated positively with the T2 relaxation time of the liver (r = 0.68, p < 0.001) and negatively with ferritin levels (r = -0.67, p < 0.001). There was no correlation with the T2 relaxation time of skeletal muscle. This study indicates that regularly transfused beta-thalassemia patients may present with a broad variation of heart iron deposition which, however, is related to serum ferritin levels.
authors.affiliation: Onassis Cardiac Surgery Center, Athens, Greece. som@aias.net.gr
authors.forename: S I
authors.initials: SI
authors.lastname: Mavrogeni
authors.forename: T
authors.initials: T
authors.lastname: Maris
authors.forename: A
authors.initials: A
authors.lastname: Gouliamos
authors.forename: L
authors.initials: L
authors.lastname: Vlahos
authors.forename: D T
authors.initials: DT
authors.lastname: Kremastinos
mesh_terms: D000328:Adult; D015415:Biomarkers; D005260:Female; D005293:Ferritins / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D010045:Outpatients; D017086:beta-Thalassemia / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D005293:Ferritins; D007501:Iron