title: Two familial mesothelioma cases with high concentrations of soluble cytokeratin 19 fragment in pleural fluid.
abstract: We report two cases of diffuse malignant pleural mesothelioma occurring almost simultaneously in one family. Patient 1 was a 42-year-old Japanese man who had worked as an electrical engineer for 25 years. Patient 2, his mother, was 69 years old. She lived for 10 years with patient 1 after he started his work, and also worked at a shipyard herself for 6 years. The concentrations of cytokeratin subunit 19 fragment (CYFRA 21-1) in pleural fluid of the two patients were 1,500 ng/ml, and 1,200 ng/ml, respectively. Measurement of CYFRA 21-1 concentration in the pleural fluid may be a useful tool for a diagnosis of malignant mesothelioma.
authors.affiliation: Department of Internal Medicine, Kure Kyosai Hospital, Hiroshima.
authors.forename: J
authors.initials: J
authors.lastname: Hiyama
authors.forename: M
authors.initials: M
authors.lastname: Marukawa
authors.forename: Y
authors.initials: Y
authors.lastname: Shiota
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: K
authors.initials: K
authors.lastname: Motohiro
authors.forename: J
authors.initials: J
authors.lastname: Aoki
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Taniyama
authors.forename: H
authors.initials: H
authors.lastname: Mashiba
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism*; D001194:Asbestos / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D002273:Carcinogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D053539:Keratin-19; D007633:Keratins; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D016273:Occupational Exposure / Q000009:adverse effects; D010375:Pedigree; D016066:Pleural Effusion, Malignant / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002273:Carcinogens; D053539:Keratin-19; C102012:antigen CYFRA21.1; D001194:Asbestos; D007633:Keratins