title: Implementation and evaluation of a new pulse sequence for rapid acquisition of double inversion recovery images for simultaneous suppression of white matter and CSF.
abstract: We describe a fast double inversion recovery (DIR) imaging sequence that effectively attenuates signal from both white matter and cerebrospinal fluid (CSF). The pulse sequence uses a novel inversion/excitation scheme and fast spin-echo readout to maximize scan efficiency. The white matter/CSF suppressed images can be acquired from the entire brain in approximately 6 minutes. Evaluation of the fast DIR sequence on patients with multiple sclerosis (MS) demonstrates high lesion conspicuity.
authors.affiliation: Department of Radiology, University of Texas at Houston Medical School, 77030, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Bedell
authors.forename: P A
authors.initials: PA
authors.lastname: Narayana
mesh_terms: D001921:Brain / Q000473:pathology*; D002555:Cerebrospinal Fluid; D003199:Computer Systems; D017352:Echo-Planar Imaging / Q000295:instrumentation; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D009103:Multiple Sclerosis / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D012984:Software