title: [Acute disseminated encephalomyelitis and meningococcal A and C vaccine: case report].
abstract: A 25-year-old women developed acute disseminated post-vaccinal encephalomyelitis (ADEM) following vaccination with A plus C meningococcal vaccine (Pasteur-Merieux). Fast disappearance of symptoms and gradual resolution of MRI demyelinating lesions occurred after steroid treatment with high doses of intravenous methylprednisolone. To our knowledge, ADEM has not been previously described in association with meningococcal vaccine. Although most cases of ADEM occur following viral infections and vaccination, the syndrome has previously been related to leptospirosis and Mycoplasma pneumoniae infections. This suggests that it may also be related to exposure to polysaccharide-protein vaccines such as the Group A plus Group C meningococcal vaccine.
authors.affiliation: Serviço de Neurologia, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro RJ, Brasil.
authors.forename: M O
authors.initials: MO
authors.lastname: Py
authors.forename: C
authors.initials: C
authors.lastname: André
mesh_terms: D000328:Adult; D001428:Bacterial Vaccines / Q000009:adverse effects*; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008589:Meningococcal Infections / Q000517:prevention & control
chemical_list: D001428:Bacterial Vaccines
vernacular_title: Encefalomielite disseminada aguda e vacinação antimeningocócica A e C. Relato de caso.