title: [Experimental study of therapeutical properties and safety of king crab collagenase-containing ointment].
abstract: The effects of ointment containing king crab (Paralithodes camtschatica) collagenase on intact skin, thermal, and pyonecrotic wounds were studied in rats by using hematological, biochemical, immunological, and morphological methods. The ointment for the skin and viscera was shown to be safe. It is highly effective in debriding the infected wounds. Different concentrations of collagenase were tested. The concentration of collagenase was recommended to be 0.2 mg/g ointment for use.
authors.forename: L S
authors.initials: LS
authors.lastname: Sandakhchiev
authors.forename: E A
authors.initials: EA
authors.lastname: Stavskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Zinov'ev
authors.forename: V P
authors.initials: VP
authors.lastname: Nazarov
authors.forename: I V
authors.initials: IV
authors.lastname: Renau
authors.forename: T N
authors.initials: TN
authors.lastname: Satrikhina
authors.forename: L R
authors.initials: LR
authors.lastname: Katkova
authors.forename: L A
authors.initials: LA
authors.lastname: Krinitsin
authors.forename: L V
authors.initials: LV
authors.lastname: Kolesnikova
authors.forename: O S
authors.initials: OS
authors.lastname: Taranov
authors.forename: V V
authors.initials: VV
authors.lastname: Omigov
authors.forename: L G
authors.initials: LG
authors.lastname: Ovechkina
authors.forename: N A
authors.initials: NA
authors.lastname: Markovich
authors.forename: E G
authors.initials: EG
authors.lastname: Malygin
authors.forename: E D
authors.initials: ED
authors.lastname: Danilenko
authors.forename: T V
authors.initials: TV
authors.lastname: Voevoda
authors.forename: L K
authors.initials: LK
authors.lastname: Fedosova
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Sizova
authors.forename: V I
authors.initials: VI
authors.lastname: Masycheva
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000009:adverse effects / Q000302:isolation & purification; D003386:Brachyura / Q000201:enzymology*; D017364:Collagenases / Q000008:administration & dosage* / Q000009:adverse effects / Q000302:isolation & purification; D004195:Disease Models, Animal; D008297:Male; D009824:Ointments; D051381:Rats; D011917:Rats, Inbred Lew; D012449:Safety; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000188:drug therapy / Q000473:pathology
chemical_list: D000891:Anti-Infective Agents, Local; D009824:Ointments; D017364:Collagenases
vernacular_title: Eksperimental'noe izuchenie lechebnykh svoĭstv mazi, soderzhashcheĭ kollagenazu kamchatskogo kraba.