title: Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Guo
authors.forename: A
authors.initials: A
authors.lastname: Pasternak
authors.forename: R
authors.initials: R
authors.lastname: Mosley
authors.forename: S
authors.initials: S
authors.lastname: Rohrer
authors.forename: E
authors.initials: E
authors.lastname: Birzin
authors.forename: F
authors.initials: F
authors.lastname: Foor
authors.forename: K
authors.initials: K
authors.lastname: Cheng
authors.forename: J
authors.initials: J
authors.lastname: Schaeffer
authors.forename: A A
authors.initials: AA
authors.lastname: Patchett
mesh_terms: D000818:Animals; D016466:CHO Cells; D002460:Cell Line; D006224:Cricetinae; D000242:Cyclic AMP / Q000819:agonists; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D051379:Mice; D008958:Models, Molecular; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017481:Receptors, Somatostatin / Q000819:agonists* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; C112853:L 54264; D008024:Ligands; D010880:Piperidines; D017481:Receptors, Somatostatin; D013006:Growth Hormone; C093733:somatostatin receptor 2; D000242:Cyclic AMP