title: Inhibitors of fatty acid oxidation (mercaptoacetate, R-3-amino-4-trimethylaminobutyric acid) stimulate feeding in mice.
abstract: Several lines of evidence indicate that fatty acid oxidation contributes to control of eating. We examined the effect of inhibitors of fatty acid oxidation (mercaptoacetate, R-3-amino-4-trimethylaminobutyric acid = emeriamine) on food intake in mice because fatty acid oxidation has been shown recently to increase the hepatic membrane potential in mouse liver, and this potential has been proposed to represent a signal for control of food intake. The effect of intraperitoneal injection of mercaptoacetate (200, 400, or 600 micromol/kg body weight) and emeriamine dihydrochloride (8.7, 17.4, 34.8, or 69.6 micromol/kg body weight) was investigated in mice fed a fat-enriched diet (18% fat). Both mercaptoacetate (400 or 600 micromol/kg) and emeriamine (34.8 or 69.6 micromol/kg) significantly increased food intake. These results suggest that fatty acid oxidation is also involved in feeding control in mice. Therefore, the pertinent mechanisms can be studied in mice.
authors.affiliation: Institute of Veterinary Physiology, University of Zurich, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Del Prete
authors.forename: T A
authors.initials: TA
authors.lastname: Lutz
authors.forename: J
authors.initials: J
authors.lastname: Althaus
authors.forename: E
authors.initials: E
authors.lastname: Scharrer
mesh_terms: D000818:Animals; D001622:Betaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002331:Carnitine; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010084:Oxidation-Reduction; D013864:Thioglycolates / Q000494:pharmacology*
chemical_list: D004041:Dietary Fats; D004791:Enzyme Inhibitors; D005227:Fatty Acids; D007004:Hypoglycemic Agents; D013864:Thioglycolates; D001622:Betaine; C017487:2-mercaptoacetate; C045761:emeriamine; D002331:Carnitine