[Case-control study of an outbreak of S. marcescens in a neonatal intensive care unit].
OBJECTIVE
To analyze an outbreak of Serratia marcescens in a neonatal intensive care unit and identify the risk factors associated to the development of infection.


METHODS
It was a case-control study from March to July 1995. Factors included were age, sex, intravascular devices, nebulizers, mechanical ventilation, use of total parenteral nutrition (TPN), underlying diseases, surgical interventions, tubes, previous antimicrobial treatment and days of exposure. The associations were explored using the odds ratio.


RESULTS
24 cases and 30 controls were included. In the univariate analysis the significant risk factors (OR,IC) were use of central venous catheter (4.57, 1.01-23.5), days of use of TPN (4.38, 1.03-16.5), days of previous antimicrobial treatment (4.87, 1.60-22) and days of exposure (2.7, 2.65-27.6). In the multivariate analysis the significant risk factors were previous antimicrobial treatment (3.98, 2.36-18.2), days of previous antimicrobial treatment (6.76, 3.02-24.6) and days of use of TPN (4.87, 1.67-15.6).


CONCLUSIONS
The significant risk factors in our study were previous antimicrobial treatment, days of antimicrobial and days of use of TPN.
Miranda-Novales
M G
MG
Unidad de Investigación de Epidemiología Hospitalaria, Centro Médico Nacional, Siglo XXI, I.M.S.S., México, D.F.
Gordillo-Pérez
M G
MG
Solórzano-Santos
F
F
Leaños-Miranda
B
B
Villasís-Keever
M A
MA
Villegas-Silva
R
R
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology; D016022:Case-Control Studies; D002405:Catheterization, Central Venous; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D008800:Mexico / Q000453:epidemiology; D015999:Multivariate Analysis; D009330:Nebulizers and Vaporizers; D016017:Odds Ratio; D010289:Parenteral Nutrition, Total; D015995:Prevalence; D012121:Respiration, Artificial; D012307:Risk Factors; D016868:Serratia Infections / Q000453:epidemiology*; D012706:Serratia marcescens
D000900:Anti-Bacterial Agents
Estudio de casos y controles en un brote de S. marcescens en una unidad neonatal de cuidados intensivos.