[cDNA cloning of three new homeobox-containing genes of Anf class from human, chicken and newt].
On the basis of the analysis of cDNA of three new homeobox-containing genes from human, chicken, and newt, a new class of homeobox genes Anf is characterized homologous to the Xanf-1 gene from Xenopus laevis, earlier cloned by us. These genes may be largely involved in the specification of embryonic subdivisions in the forebrain region of the embryo. The homeodomains of the proteins encoded by these genes differ greatly in the primary structure from all previously described homeobox genes. The high variability of the homeodomain sequences of the proteins of this class imply their rapid evolution.
Kazanskaia
O V
OV
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Ermakova
G V
GV
Pannese
M
M
Boncinelli
E
E
Zaraĭskiĭ
A G
AG
D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo; D003001:Cloning, Molecular; D017931:DNA Primers; D018076:DNA, Complementary / Q000235:genetics*; D004475:Ectoderm / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D005801:Genes, Homeobox / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010999:Pleurodeles; D016133:Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D029867:Xenopus Proteins
D017931:DNA Primers; D018076:DNA, Complementary; C098129:HESX1 protein, Xenopus; D018398:Homeodomain Proteins; D029867:Xenopus Proteins
Klonirovanie kDNK trekh novykh gomeobokssoderzhashchikh genov klassa Anf iz cheloveka, kuritsy i ispanskogo tritona.