title: Characterization of atherosclerotic plaque components by high resolution quantitative MR and US imaging.
abstract: High resolution MRI at 3 T and US imaging at 50 MHz were used for atherosclerotic plaque characterization. For 14 excised segments of human arteries, conventional MR and US images, quantitative MR T2 maps, US integrated attenuation (IA) maps, and histologic sections were produced and compared. The MR T2 and US attenuation mean values estimated in selected regions of interest were related with tissue type as identified on histologic sections. Significant distinction between media or collagen and lipid or collagen lipidic plaque was achieved with both techniques (MR: P < .001; US: P < .01). Significant distinction was obtained between media and collagen (P < .0001) and between iliac and aortic media (P < .05) with MR T2 but not with IA. MR and US native and parametric images, with different sensitivities to tissue type, provide complementary information useful for quantitative plaque characterization.
authors.affiliation: Service Hospitalier Fridiric Joliot, DRM-CEA, Orsay, France. jraynaud@myologie.infobiogen.fr
authors.forename: J S
authors.initials: JS
authors.lastname: Raynaud
authors.forename: S L
authors.initials: SL
authors.lastname: Bridal
authors.forename: J F
authors.initials: JF
authors.lastname: Toussaint
authors.forename: P
authors.initials: P
authors.lastname: Fornès
authors.forename: V
authors.initials: V
authors.lastname: Lebon
authors.forename: G
authors.initials: G
authors.lastname: Berger
authors.forename: A
authors.initials: A
authors.lastname: Leroy-Willig
mesh_terms: D000368:Aged; D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000473:pathology; D003094:Collagen / Q000378:metabolism; D005260:Female; D006801:Humans; D007083:Iliac Artery / Q000473:pathology; D007089:Image Enhancement; D050356:Lipid Metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014463:Ultrasonography
chemical_list: D003094:Collagen