[The anti-arrhythmia action of an extract of Rhodiola rosea and of n-tyrosol in models of experimental arrhythmias].
A daily 8-day course of Rhodiolae fluidum extract (1 ml/kg; ED50 = 0.43 ml/kg)--a preparation from the group of adaptogens caused a marked preventive antiarrhythmic effect on models of adrenaline and CaCl2-induced, but not acontine, arrhythmias. Aglycone--n-tyrosol demonstrated a lower antiarrhythmic activity (ED50 = 16 mg/kg) than that of Rhodiola extract.
Maĭmeskulova
L A
LA
Department of Experimental Cardiology, Russian Academy of Medical Sciences, Tomsk Research Center, Russia.
Maslov
L N
LN
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002122:Calcium Chloride; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D010936:Plant Extracts; C011867:4-hydroxyphenylethanol; D002122:Calcium Chloride; D010626:Phenylethyl Alcohol; D000157:Aconitine
Izuchenie antiaritmicheskogo deĭstviia ékstrakta rodioly rozovoĭ i n-tirozola na modeliakh éksperimental'nykh aritmiĭ.