title: Computer-assisted molecular design for the determination of structure-activity relationships for chemopreventive agents.
authors.affiliation: Institute of Immunology, University Witten/Herdecke, Germany. hqlue@uwh.de
authors.forename: H Q
authors.initials: HQ
authors.lastname: Lü
authors.forename: U
authors.initials: U
authors.lastname: Schmitz
authors.forename: B
authors.initials: B
authors.lastname: Niggemann
authors.forename: K S
authors.initials: KS
authors.lastname: Zänker
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D002277:Carcinoma / Q000517:prevention & control*; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D018890:Chemoprevention; D017076:Computer-Aided Design; D003374:Coumarins / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D006147:Guanine / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D017354:Point Mutation / Q000235:genetics; D011485:Protein Binding; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014468:Umbelliferones / Q000737:chemistry* / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D014468:Umbelliferones; D006147:Guanine; C031477:7-hydroxycoumarin; D006160:Guanosine Triphosphate; C030123:coumarin; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)