Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human estrogen receptor beta locus.
A gene for a second type of human estrogen receptor, the estrogen receptor beta (ESR beta), was recently identified. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human estrogen receptor beta gene. High heterozygosity (0.93) makes this polymorphism a useful marker in the genetic study of disorders affecting female endocrine systems; calcium metabolism; and breast, uterine, and ovarian cancers.
Tsukamoto
K
K
Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan.
Inoue
S
S
Hosoi
T
T
Orimo
H
H
Emi
M
M
D000483:Alleles; D001483:Base Sequence; D002118:Calcium / Q000378:metabolism; D002874:Chromosome Mapping; D017931:DNA Primers / Q000235:genetics; D018900:Dinucleotide Repeats; D047629:Estrogen Receptor beta; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*
D017931:DNA Primers; D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen; D002118:Calcium