title: [Acute myocardial infarction secondary to Wegener's granulomatosis].
abstract: Wegener's granulomatosis (WG) is a necrotizing and granulomatous vasculitis that usually affects the upper and lower respiratory tract and the kidneys. Cardiac involvement is rare although pericarditis, coronary arteritis, myocarditis, valvulitis and arrhythmias have been described. Acute myocardial infarction with clinical expression is an exceptional complication of Wegener's granulomatosis. We report a case of a 30-year-old man with Wegener's granulomatosis who suffered an acute myocardial infarction during the initial phase of the disease, following seven days of treatment with glucocorticoids and cyclophosphamide. Transthoracic echocardiography showed abnormal regional wall motion with septal hypokinesia and apical akinesia. Cardiac catheterization revealed an ectasic segment in the proximal left anterior descending coronary artery and total occlusion in the mid-segment. Medical therapy with prednisone and cyclophosphamide was continued. No complications and initial remission were achieved.
authors.affiliation: Servicio de Cardiología, Hospital La Paz, Madrid.
authors.forename: J
authors.initials: J
authors.lastname: Fuertes Beneitez
authors.forename: F
authors.initials: F
authors.lastname: García-Iglesias
authors.forename: P
authors.initials: P
authors.lastname: Gallego García de Vinuesa
authors.forename: A
authors.initials: A
authors.lastname: García-Tobaruela
authors.forename: J A
authors.initials: JA
authors.lastname: Gómez-Guindal
authors.forename: P
authors.initials: P
authors.lastname: Lavilla Uriol
authors.forename: A
authors.initials: A
authors.lastname: Gil Aguado
authors.forename: J A
authors.initials: JA
authors.lastname: Sobrino Daza
authors.forename: L
authors.initials: L
authors.lastname: Martín-Jadraque
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D017023:Coronary Angiography; D003520:Cyclophosphamide / Q000627:therapeutic use; D004562:Electrocardiography; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011241:Prednisone
vernacular_title: Infarto agudo de miocardio secundario a granulomatosis de Wegener.