title: Organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(acylhydrazones). Synthesis, structure, antimicrobial activity and genotoxicity.
abstract: Mono- and bimetallic organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(2-hydroxybenzoylhydrazone) (H5dfps) and pyrrole-2,5-dicarboxaldehyde bis(2-picolinoylhydrazone) (H3dfpp) were synthesized and characterized by IR, 1H and 119Sn NMR spectroscopy. X-ray analysis of the complex [Sn(H3dfps)(C6H5)2].(CH3)2SO revealed a pentacoordination around tin through a N,N,O terdentate ligand behaviour of the hydrazone. This complex is the most active compound, exhibiting MIC values of 3 and 12 micrograms/ml against Gram positive and Gram negative bacteria, respectively. None of the ligands or complexes produced DNA-damage in the Bacillus subtilis rec-assay or showed mutagenic activity in the Salmonella-microsome test.
authors.affiliation: Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Università di Parma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bacchi
authors.forename: A
authors.initials: A
authors.lastname: Bonardi
authors.forename: M
authors.initials: M
authors.lastname: Carcelli
authors.forename: P
authors.initials: P
authors.lastname: Mazza
authors.forename: P
authors.initials: P
authors.lastname: Pelagatti
authors.forename: C
authors.initials: C
authors.lastname: Pelizzi
authors.forename: G
authors.initials: G
authors.lastname: Pelizzi
authors.forename: C
authors.initials: C
authors.lastname: Solinas
authors.forename: F
authors.initials: F
authors.lastname: Zani
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004249:DNA Damage; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D008958:Models, Molecular; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D009947:Organotin Compounds