title: Treatment of insomnia by concomitant therapy with Zopiclone and Aniracetam in patients with cerebral infarction, cerebroatrophy, Alzheimer's disease and Parkinson's disease.
abstract: For insomniac patients, sleeping drugs are used: in addition, concomitant therapy with other drugs has been tried in an effort to prevent a decrease in the effects due to long-term continuous use. This report presents the results of a study on the sleeping effects in nine aged patients with insomnia associated with cerebrovascular and noncerebrovascular disorders who received concomitant therapy with Zopiclone and Aniracetam. The treatment in 7/9 cases (78%) was found to be effective, showing more than 50% prolongation of sleeping time, and in two cases (22%) was found to be ineffective. We discuss the mechanism of action referring to the literature.
authors.affiliation: Department of Internal Medicine, Tachikawa Medical Center, Omotemachi Hospital, Nagoya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Katsunuma
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Kubo
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: A
authors.initials: A
authors.lastname: Yoshihama
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D001284:Atrophy; D053961:Azabicyclo Compounds; D002540:Cerebral Cortex / Q000473:pathology*; D002544:Cerebral Infarction / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D018697:Nootropic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D010300:Parkinson Disease / Q000188:drug therapy*; D010879:Piperazines / Q000008:administration & dosage* / Q000009:adverse effects; D017286:Polysomnography; D011760:Pyrrolidinones / Q000008:administration & dosage* / Q000009:adverse effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D012894:Sleep Stages / Q000187:drug effects
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D018697:Nootropic Agents; D010879:Piperazines; D011760:Pyrrolidinones; C515050:zopiclone; C036466:aniracetam