[The complement-activating action of modern x-ray contrast agents].
The study conducted proved that triombrast (dose dependently) > hexabrics > Ultravist > or = melitrast = omnipac in a concentration interval of 0.03-30.0 mg iodine/ml in vitro and in a dose interval of 0.5-2.0 g iodine/kg in vivo activate the complement system (CS) according to the alternative way in the blood of "sensitive" rats. The degree of CS activation by radiopaque agents (ROA) is significantly determined mathematically by their viscosity and relation of the number of iodine atoms to the number of ions or dissolved particles, and by their hydrophilic (for nonion CS) and osmotic (for ion monomeric CS) properties.
Napolov
Iu K
IuK
Department of Molecular Pharmacology and Radiobiology, Russian State Medical University, Moscow, Russia.
Bolotova
E N
EN
Shimanovskiĭ
N L
NL
D000818:Animals; D003167:Complement Activation / Q000187:drug effects*; D015941:Complement Hemolytic Activity Assay / Q000706:statistics & numerical data; D003170:Complement Pathway, Alternative / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D016014:Linear Models; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D003287:Contrast Media
Komplementaktiviruiushchee deĭstvie sovremennykh rentgenokontrastnykh sredstv.