Rheumatic fever. The relationships between host, microbe, and genetics.
Acute rheumatic fever is a delayed, nonsuppurative sequela of a pharyngeal infection with the group A streptococcus. The onset of the disease is usually characterized by an acute febrile illness; however, there may be chronic involvement of the heart and/or central nervous system. The article explores the relationship between the initial infection and host-microbial interactions that may be operative in disease pathogenesis.
Gibofsky
A
A
Hospital for Special Surgery, Cornell University Medical College, New York, New York, USA.
Kerwar
S
S
Zabriskie
J B
JB
D000942:Antigens, Bacterial / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology*; D006801:Humans; D012213:Rheumatic Fever / Q000235:genetics / Q000276:immunology / Q000382:microbiology
D000942:Antigens, Bacterial