2D 1H and 13C NMR evidence for stereoselective formation of a new bond C-N, C-S or C-C in the reaction of ivalin acetate with substituted pyrimidines.
Several pyrimidine derivatives of ivalin acetate were synthesized as potential anti HIV agents. High stereoselective Michael addition to ivaline acetate was observed and a new C-C, C-N or C-S bond was formed. 2D NMR 1H and 13C as well as X-ray crystallographic studies were performed on the compounds herein described to establish the structure and stereochemistry.
Diaz
E
E
University Nacional Autonoma de México, Instituto de Química, México, D.F., México.
Nava
J L
JL
Barrios
H
H
Quiroz
B
B
Guzman
A
A
León
L
L
Fuentes
A
A
D000478:Alkylation; D019380:Anti-HIV Agents / Q000737:chemistry*; D002244:Carbon; D018360:Crystallography, X-Ray; D007783:Lactones; D008956:Models, Chemical; D008958:Models, Molecular; D009584:Nitrogen; D011487:Protein Conformation; D011743:Pyrimidines / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*; D013237:Stereoisomerism; D013455:Sulfur
D019380:Anti-HIV Agents; D007783:Lactones; D011743:Pyrimidines; D012717:Sesquiterpenes; C049171:ivalin; D013455:Sulfur; D002244:Carbon; D009584:Nitrogen