[A preclinical trial of iodoantipyrine safety].
Detailed preclinical study of the safety of the new antiviral agent iodantipyrine was conducted. In LD50 parameters it was found to be related to moderately toxic drugs. Long-term administration in doses of 50, 100, and 250 mg/kg did not cause any essential functional and structural disorders in the organs and systems of rats and dogs. Iodantipyrine does not possess mutagenic and allergenic properties and does not affect the reproductive function.
Saratikov
A S
AS
Siberian Medical University, Tomsk, Russia.
Novozheeva
T P
TP
Livshits
N S
NS
Burchenkova
F I
FI
Kadychagova
N G
NG
Akhmedzhanov
R R
RR
Bashirova
L V
LV
Eremina
A A
AA
Potapova
G V
GV
D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000633:toxicity; D000998:Antiviral Agents / Q000633:toxicity*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000276:immunology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D011247:Pregnancy; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013997:Time Factors
D000998:Antiviral Agents; D000983:Antipyrine; C008135:iodoantipyrine
Doklinicheskaia otsenka bezopasnosti ĭodantipirina.