title: Gastroduodenal mucosa in peptic ulcer: endoscopic and histological assessment.
abstract: This study aimed to assess the prevalence of endoscopic and histological gastroduodenitis as well as helicobacter-like organisms in patients with peptic ulcer. After diagnostic endoscopy, gastroduodenal biopsy specimens were taken from thirty patients (n = 30) with clinical and endoscopic diagnosis of peptic ulcer (duodenal ulcer = 25, gastric ulcer = 5). Endoscopic gastroduodenitis occurred in 18 patients (60%). Histological gastritis was detected in the gastric body or antrum in 25 (83%) and duodenitis in 17 (57%) patients. There was significant correlation between endoscopic and histological gastritis (p < 0.05). Helicobacter-like organisms occurred in 73% of the patients with peptic ulcer and in 88% of the antral biopsy specimens showing antral gastritis. Presence of helicobacter-like organisms was in particular associated with acute on chronic gastritis compared to chronic gastritis (p < 0.01). Moreover the patients with gastritis were found to belong to the older age group and 81.8% had blood group O +ve (p < 0.01 and p < 0.05 respectively). We conclude that presence of helicobacter-like organisms in patients with peptic ulcer is significantly associated with acute on chronic gastritis.
authors.affiliation: Medical College Hospital, Calcutta, India.
authors.forename: G
authors.initials: G
authors.lastname: Chattopadhyay
authors.forename: K
authors.initials: K
authors.lastname: Basu
authors.forename: S
authors.initials: S
authors.lastname: Mukherjee
authors.forename: B R
authors.initials: BR
authors.lastname: Hazra
mesh_terms: D000328:Adult; D004381:Duodenal Ulcer / Q000382:microbiology / Q000473:pathology*; D004382:Duodenitis / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D013276:Stomach Ulcer / Q000382:microbiology / Q000473:pathology*