title: [CD30 positive large T-cell primary cutaneous lymphoma].
abstract: The primary cutaneous CD30 positive large cell lymphoma is a rare tumor, confined to the skin. The characteristic clinical picture is a large, often exulcerating sometimes spontan regressing tumor or nodule. Dense infiltration of large, anaplastic or non-anaplastic T or non T, non B cell of the dermis is characteristic. Generalization, lymph node or internal manifestation is rare, the prognosis is favourable. A 25-year-old male patient is presented, in whom generalised skin symptoms-itching, reddish-brownish papules with central necrosis developed. Two years later general symptoms-fever, fatigue, lymph node and spleen enlargement, increased in white blood cell count with prominent eosinophilia, increase in CD4 number occurred. The histology and immunohistology of the skin and peripheral lymph node showed large, anaplastic, CD30 positive T cell infiltration. CHOP, then BACOP treatment resulted in regression of the skin and the internal symptoms.
authors.affiliation: Bör-és Nemikórtani Klinika, Semmelweis Orvostudományi Egyetem Budapest.
authors.forename: M
authors.initials: M
authors.lastname: Marschalkó
authors.forename: A
authors.initials: A
authors.lastname: Szigeti
authors.forename: J
authors.initials: J
authors.lastname: Hársing
authors.forename: G
authors.initials: G
authors.lastname: Kelényi
authors.forename: A
authors.initials: A
authors.lastname: Horváth
mesh_terms: D000328:Adult; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology*; D008297:Male; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D017730:Ki-1 Antigen
vernacular_title: CD30 pozitív, nagy T-sejtes primer cutan lymphoma.