[Effects of tumor necrosis factor antiserum of the course of Marburg hemorrhagic fever].
The paper provides data on the effect of tumor necrosis factor (TNF) antiserum on the course of experimental Marburg hemorrhagic fever. On day 3 of the challenge of guinea pigs with the Popp strain of Marburg virus, the infection event was confirmed by PCR. On days 4-7, the infected animals intramuscularly received a TNF-alpha antiserum. The treated animals showed a 50% survival while all control animals died. It may be assumed that a course of death due to Marburg hemorrhagic fever in shocks brought about by inflammatory cytokines. Therefore, attempts may be made to treat this infection by using the drugs that are TNF antagonists.
Ignat'ev
G M
GM
Strel'tsova
M A
MA
Kashentseva
E A
EA
Patrushev
N A
NA
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D004587:Electrophoresis, Agar Gel; D005500:Follow-Up Studies; D006168:Guinea Pigs; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D007116:Immunization, Passive; D008379:Marburg Virus Disease / Q000378:metabolism / Q000628:therapy*; D029024:Marburgvirus / Q000235:genetics / Q000276:immunology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D000914:Antibodies, Viral; D007106:Immune Sera; D012367:RNA, Viral; D014409:Tumor Necrosis Factor-alpha
Vliianie syvorotki protiv faktora nekroza opukholi na techenie gemorragicheskoĭ likhoradki marburg.