title: [Cytogenetic analysis of hypophyseal adenoma. Study of 9 cases and review of the literature].
abstract: BACKGROUND
  To the best of our knowledge, no specific chromosomal abnormalities have been found in the literature in pituitary adenomas. In the present study, we investigated 9 cases of pituitary adenoma and reviewed the current literature.
  
  
  METHODS
  Nine cases of pituitary adenoma have been studied with immunohistochemistry and cytogenetic using short-term cultures.
  
  
  RESULTS
  All tumors had a normal karyotype. Three cases were clinically non-secreting adenomas, three cases produced prolactin, two showed growth hormone production and one thyroid-stimulating hormone. One of the cases showed dural invasion.
  
  
  CONCLUSIONS
  We compared our results with those published in the current literature. It appears that pituitary adenomas do not have specific numerical and structural abnormalities and mostly show a normal karyotype.
authors.affiliation: Dipartimento di Oncologia, Ospedale Bellaria, Università di Bologna.
authors.forename: L
authors.initials: L
authors.lastname: Buonamici
authors.forename: F
authors.initials: F
authors.lastname: Roncaroli
authors.forename: G
authors.initials: G
authors.lastname: Frank
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
authors.forename: F
authors.initials: F
authors.lastname: Calbucci
authors.forename: V
authors.initials: V
authors.lastname: Eusebi
mesh_terms: D000236:Adenoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011388:Prolactin / Q000378:metabolism; D015175:Prolactinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D019382:Human Growth Hormone; D011388:Prolactin; D013972:Thyrotropin
vernacular_title: Analisi citogenetica degli adenomi ipofisari. Studio di 9 casi e revisione della letteratura.