title: In vitro activities of the new ketolide antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany.
abstract: The comparative in vitro activity of HMR 3004 and HMR 3647, new ketolide antibiotics, was tested by a standard agar dilution technique against 221 pneumococcal strains, including isolates with intermediate levels of resistance to penicillin and erythromycin-resistant isolates. The ketolides were more active than other macrolides and showed excellent activity against erythromycin-resistant strains. All the strains were inhibited by < or = 2 micrograms of HMR 3004/ml or by < or = 0.5 microgram of HMR 3647/ml.
authors.affiliation: National Reference Center for Streptococci, Institute of Medical Microbiology, University Hospital (RWTH) Aachen, Germany. Reinert@RWTH-Aachen.de
authors.forename: R R
authors.initials: RR
authors.lastname: Reinert
authors.forename: A
authors.initials: A
authors.lastname: Bryskier
authors.forename: R
authors.initials: R
authors.lastname: Lütticken
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D004917:Erythromycin / Q000494:pharmacology; D005858:Germany; D006801:Humans; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C105420:RU 64004; D004917:Erythromycin; C106791:telithromycin