title: Predictors of adverse events after the administration of acellular and whole-cell diphtheria-tetanus-pertussis vaccines.
abstract: Recurrence of adverse events, the effect of site of injection, and concurrent administration of oral polio vaccine (OPV) and hepatitis B vaccine (HBV) on reactogenicity were assessed in recipients of two acellular pertussis vaccines given in combination with diphtheria and tetanus toxoids (DTaP), one whole-cell DTP vaccine (DTPwc) and one DT vaccine during a double blind, randomized, controlled clinical trial. Local and systemic side reactions were more likely to recur after the administration of DTaP and DT compared with DTPwc. In all vaccine groups, injection in the buttock was associated with a lower rate of common adverse events compared with injection in the thigh, while simultaneous administration of OPV and/or HBV did not increase the risk of onset of side reactions.
authors.affiliation: Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore di Sanità, Roma, Italy.
authors.forename: A E
authors.initials: AE
authors.lastname: Tozzi
authors.forename: M L
authors.initials: ML
authors.lastname: Ciofi degli Atti
authors.forename: S G
authors.initials: SG
authors.lastname: Wassilak
authors.forename: S
authors.initials: S
authors.lastname: Salmaso
authors.forename: P
authors.initials: P
authors.lastname: Panei
authors.forename: A
authors.initials: A
authors.lastname: Anemona
authors.forename: S
authors.initials: S
authors.lastname: Luzi
authors.forename: D
authors.initials: D
authors.lastname: Greco
mesh_terms: D004165:Diphtheria / Q000517:prevention & control*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D013742:Tetanus / Q000517:prevention & control*; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine