Syntheses of some new 4-chloro-2-mercapto-N(4H-1,2,4-triazol-3-yl) benzenesulphonamide with potential anticancer or anti-HIV activity.
4-Chloro-2-mercapto-5-R1-N-(4-R2-4H-1,2,4-triazol-3-yl) benzenesulphonamide [VIII-XIV] were prepared from the corresponding 4-chloro-3(R2-amino)-5-R1-1,1-dioxo-1,4, 2-benzodithiazines [I-VII] then compd. [VIII-X] were S-carboxyalkylated to the corresponding 2-¿5-chloro-4-methyl-2-[4-R2-4H-1,2,4-triazol-3-yl)aminosulphon yl] phenylthio¿alkanoic acids [XVII-XXVI]. Preliminary screening of anti HIV-1 and anticancer activity of compd. [XI,XII,XVII] was conducted.
Sławiński
J
J
Department of Chemical Drug Technology, Medical University of Gdańsk, Poland.
D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D013449:Sulfonamides