Cell cycle control and cancer: lessons from lung cancer.
Recent developments in the study of the cell cycle have shed much light on the origins of human cancer. We summarize these developments with an emphasis on the molecular characterization and the functional role of the cyclin-dependent kinase family of protein kinases (CDK) and their associated regulatory subunits. The Rb tumor suppressor in the progression from the G1 to S phase of the cell cycle and in tumor development is used as a paradigm for illustrating the importance of understanding the molecular regulatory events in the etiology of cancer. Recent developments with cyclin-dependent kinase inhibitors, most notably, p16 (CDKN2), indicate that these molecules represent new tumor suppressors in both skin and lung cancers. Insights from these cell cycle studies can provide avenues for the diagnosis, prognosis, and potential gene and chemotherapies for many cancers, including non-small cell lung cancer.
Sclafani
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Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, USA.
Schauer
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D002453:Cell Cycle; D018797:Cell Cycle Proteins; D002455:Cell Division; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000502:physiology; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000502:physiology; D016147:Genes, Tumor Suppressor; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D014157:Transcription Factors / Q000502:physiology; D025521:Tumor Suppressor Proteins
C493956:CDKN1A protein, human; C493966:CDKN2B protein, human; D018797:Cell Cycle Proteins; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins