[Late effects of ionizing radiations on central nervous system, spinal cord and peripheral nerves].
Despite the lack of characteristic features, demyelination is the dominant feature of radiation induced late effects observed in cerebral nervous system and spinal cord. Acute, subacute and chronic changes are described in terms of pathological, clinical and radiological observations. Brain necrosis in adults is rarely noted below 60 Gy in conventional fractionation, while imaging changes are observed with lower doses. The most widely observed dose limit for the spinal cord is 45 Gy, in the absence of dose modifying chemotherapy. Tumor progression may be hard to distinguish from radiochemotherapy effects. The potential protective role of hyperfractionation is not yet clearly established. Peripheral nerves late effects, although rare, are described.
Mornex
F
F
Département d'oncologie-radiothérapie, EA 643, centre hospitalier Lyon-Sud, Pierre-Bénite, France.
Beauvois
S
S
Van Houtte
P
P
D001921:Brain / Q000528:radiation effects*; D001929:Brain Edema / Q000209:etiology / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D009408:Nerve Compression Syndromes / Q000209:etiology / Q000503:physiopathology; D009443:Neuritis / Q000209:etiology / Q000503:physiopathology; D017933:Peripheral Nervous System / Q000528:radiation effects*; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects* / Q000379:methods; D011879:Radiotherapy Dosage; D013116:Spinal Cord / Q000528:radiation effects*
Effets tardifs des radiations ionisantes sur le système nerveux central, la moelle épinière, les nerfs périphériques.