[Effect of phenyl derivative of gamma-aminobutyric acid phenybut on autorhythmic contractile activity of the portal vein].
The phenyl derivative of the GABA phenybute exerts a direct regulating effect upon phasic and tonic components of the v.cava autorhythmical contractile activity in Wistar rats in media with an altered calcium contents, whereas no such effect occurred in hyper-potassium solution or against the background of verapamil blockade of the potential-dependent calcium channels.
Ogluzdina
M V
MV
Pavlov 1st Medical University, St. Petersburg, Russia.
Barabanova
V V
VV
Berestovitskaia
V M
VM
Usik
N V
NV
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D018682:GABA Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D011169:Portal Vein / Q000187:drug effects* / Q000502:physiology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014700:Verapamil / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D002121:Calcium Channel Blockers; D018682:GABA Agents; D005680:gamma-Aminobutyric Acid; D014700:Verapamil; D011188:Potassium; D002118:Calcium; C008842:4-amino-3-phenylbutyric acid
Vliianie fenil'nogo proizvodnogo gamma-aminomaslianoĭ kisloty fenibuta na avtoritmicheskuiu sokratitel'nuiu aktivnost' vorotnoĭ veny.