Nicotine induced inhibition of the activities of accessory reproductive ducts in male rats.
Adult male albino rats were treated with 0.4 mg nicotine/100 g body weight either orally or intraperitoneally for 30 days. All animals were autopsied on the 31st day. Epididymis and vas deferens were dissected out, weighed and processed for biochemical estimations. Nicotine caused a reduction in the weight of epididymis and vas deferens in both drug treated groups. The total cholesterol content is increased while protein, DNA and RNA contents and the epididymal sperm count were decreased. The acid phosphatase content is also decreased, whereas alkaline phosphatase is increased. The surface epithelial cell height of these ducts is decreased and secretory activity is reduced with the disruption of epithelial cell projections. These changes may be due to non-availability of androgens in nicotine treated rats.
Londonkar
R L
RL
Department of Zoology, Gulbarga University, India.
Srinivasreddy
P
P
Somanathreddy
P
P
Patil
S B
SB
D000135:Acid Phosphatase / Q000032:analysis; D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D004822:Epididymis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004847:Epithelial Cells / Q000187:drug effects; D005731:Ganglionic Stimulants / Q000008:administration & dosage / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000633:toxicity*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count / Q000187:drug effects; D013079:Sperm Maturation / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects* / Q000473:pathology
D005731:Ganglionic Stimulants; D018722:Nicotinic Agonists; D009538:Nicotine; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase