title: Measurement of chemical shifts and coupling constants for glutamate and glutamine.
abstract: Proton chemical shifts and coupling constants were obtained for glutamate and glutamine in water (D2O) at pH = 6.6. Initial chemical shift and coupling constant values obtained from experimental spectra were refined using a spectral simulation and optimization program to get a complete set of values that could not otherwise be measured directly from the experimental spectra due to strong spin-spin couplings. These values are essential for automated spectral fitting procedures that require a priori information.
authors.affiliation: Department of Radiology, University of California San Francisco, VA Medical Center, 94121, USA.
authors.forename: V
authors.initials: V
authors.lastname: Govindaraju
authors.forename: V J
authors.initials: VJ
authors.lastname: Basus
authors.forename: G B
authors.initials: GB
authors.lastname: Matson
authors.forename: A A
authors.initials: AA
authors.lastname: Maudsley
mesh_terms: D001921:Brain / Q000033:anatomy & histology*; D003198:Computer Simulation; D005583:Fourier Analysis; D018698:Glutamic Acid / Q000032:analysis*; D005973:Glutamine / Q000032:analysis*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy
chemical_list: D005973:Glutamine; D018698:Glutamic Acid