title: [Lupus erythematosus/lichen ruber planus overlap syndrome. 5 cases in a patient sample of the Erlangen University Dermatology Clinic (1894-1995)].
abstract: The simultaneous occurrence of lupus erythematosus (LE)- and lichen ruber (LP)-like symptoms is called LE/LP-overlap syndrome (LE/LP-OS). It is defined by concomitant clinical, histologic and immunhistologic features of both diseases. To date, 47 cases of this rare dermatosis have been reported with marked differences in the skin lesions: They are either of intermediate appearance between LE and LP (type I = intermediate type), or show a coexistence of LE- and LP-specific lesions (type II = polar type). To determine the frequency and characteristics of the LE/LP-OS we reviewed our LE-patients from 1984-1995. 5 cases were diagnosed. The frequency of LE/LP-OS in our patients is higher than generally assumed. Due to its variable clinical, histological and immunhistological appearance and the lack of unequivocal pathognomonic signs, this overlap-dermatosis may be underdiagnosed. Since therapeutic consequences result from the diagnosis, criteria are suggested to facilitate the recognition of the LE/LP-OS.
authors.affiliation: Dermatologische Universitätsklinik Erlangen.
authors.forename: V
authors.initials: V
authors.lastname: Mahler
authors.forename: O P
authors.initials: OP
authors.lastname: Hornstein
authors.forename: S
authors.initials: S
authors.lastname: Meyer
authors.forename: H P
authors.initials: HP
authors.lastname: Albrecht
authors.forename: F
authors.initials: F
authors.lastname: Kiesewetter
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D003165:Complement System Proteins / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008010:Lichen Planus / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000276:immunology / Q000473:pathology; D013577:Syndrome
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007136:Immunoglobulins; D003165:Complement System Proteins
vernacular_title: Lupus-erythematodes-/Lichen-ruber-planus-Overlap-Syndrom. 5 Fälle im Patientengut der Dermatologischen Universitätsklinik Erlangen (1984-1995).