Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives.
A series of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diesters substituted at the N-1 and/or C-4 positions of the dihydropyridine ring was synthesized. The in vitro cytotoxicity and in vitro and in vivo radioprotective efficacy of these agents were evaluated in Chinese hamster (V-79) cells and CD2F1 male mice, respectively. Compounds with at least one adamantyl substituent afforded better radioprotection than those without this substituent. Substitution of an aromatic ring at the C-4 position of the dihydropyridine ring did not enhance the radioprotectant action of the compounds.
Donkor
I O
IO
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis 38163, USA.
Zhou
X
X
Schmidt
J
J
Agrawal
K C
KC
Kishore
V
V
D000218:Adamantane / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*
D004095:Dihydropyridines; D011837:Radiation-Protective Agents; C038806:1,4-dihydropyridine; D000218:Adamantane