title: Synteny mapping of four genes from the short arm of human chromosome 19 to bovine chromosome 7.
abstract: Four genes on the short arm of human chromosome 19 (HSA 19p) were assigned to bovine chromosome 7 (BTA 7) using a bovine x rodent somatic hybrid cell panel. These four genes were cartilage oligomeric matrix protein (COMP), lymphoblastic leukemia derived sequence 1 (LYL1), lysosomal alpha-mannosidase (MANB), and RAS oncogene family member RAB3A. Bovine sequence tagged sites were developed for the four genes and used for screening a bovine x rodent somatic cell panel. All four genes were mapped to bovine synteny group U22 (BTA 7) with a correlation coefficient of 0.901-1.000. This study confirms that the centromeric region of BTA 7 is conserved with HSA 19p.
authors.affiliation: Department of Animal Sciences, University of Wisconsin-Madison, 53706, USA.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Gu
authors.forename: J E
authors.initials: JE
authors.lastname: Womack
authors.forename: B W
authors.initials: BW
authors.lastname: Kirkpatrick
mesh_terms: D000818:Animals; D002356:Cartilage; D064236:Cartilage Oligomeric Matrix Protein; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D002888:Chromosomes, Human, Pair 19; D016326:Extracellular Matrix Proteins; D011905:Genes, ras; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics; D008361:Mannosidases / Q000235:genetics; D064235:Matrilin Proteins; D016324:Sequence Tagged Sites; D043323:alpha-Mannosidase
chemical_list: D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; C577553:TSP5 protein, human; D008361:Mannosidases; D043323:alpha-Mannosidase