Post-feeding increases in accumbal dialysate dopamine reflect persisting increases in dopamine release.
To determine whether post-feeding increases in dialysate dopamine (DA) in the nucleus accumbens are associated with persisting increases in DA release, we examined the effect of Ca++-free perfusion on post-feeding dialysate concentrations of DA. Post-feeding dialysate DA is entirely Ca++-dependent, suggesting the existence of post-feeding increases in exocytotic DA release and the ability of microdialysis to monitor dynamic changes in DA release through behaviour.
Kaneyuki
H
H
Division of Neurological Sciences, Department of Psychiatry, University of British Columbia, Vancouver, Canada. kaneyuki@po.cc.yamaguchi-u.ac.jp
Wilson
C
C
D000818:Animals; D016477:Artifacts; D004298:Dopamine / Q000378:metabolism*; D005247:Feeding Behavior / Q000502:physiology*; D008297:Male; D017551:Microdialysis; D009714:Nucleus Accumbens / Q000378:metabolism*; D019518:Postprandial Period; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D004298:Dopamine