title: Malignant meningioma of the oculomotor nerve without dural attachment. Case report and review of the literature.
abstract: Meningiomas, thought to arise from arachnoid cap cells, are usually attached to the dura. Malignancy is present in approximately 1% of these tumors. The authors report the case of a patient with a malignant meningioma arising from the oculomotor nerve with no dural attachment. The patient presented with a 7-month history of left-sided ptosis and diplopia. Magnetic resonance imaging demonstrated an extrinsic mass compressing the root of the oculomotor nerve at its exit from the midbrain. During surgery, a left-sided subtemporal approach revealed the tumor to be arising from the oculomotor nerve. Histological investigation showed a malignant spindle cell lesion with an immunohistochemical profile that was consistent with malignant meningioma. To the authors' knowledge, this is the first documented case of a malignant meningioma arising from the oculomotor nerve.
authors.affiliation: Gough-Cooper Department of Neurological Surgery, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, United Kingdom. Alister.Hart@Virgin.net
authors.forename: A J
authors.initials: AJ
authors.lastname: Hart
authors.forename: J
authors.initials: J
authors.lastname: Allibone
authors.forename: A T
authors.initials: AT
authors.lastname: Casey
authors.forename: D G
authors.initials: DG
authors.lastname: Thomas
mesh_terms: D000328:Adult; D001099:Arachnoid / Q000473:pathology; D001763:Blepharoptosis / Q000175:diagnosis; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis* / Q000473:pathology; D004172:Diplopia / Q000175:diagnosis; D004388:Dura Mater / Q000473:pathology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology; D018396:Mucin-1 / Q000032:analysis; D009802:Oculomotor Nerve / Q000473:pathology*; D010243:Paralysis / Q000175:diagnosis; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D005904:Glial Fibrillary Acidic Protein; D018396:Mucin-1; D009418:S100 Proteins; D014746:Vimentin