Mycoplasma hyorhinis infection of pigs selectively bred for high and low immune response.
Pigs have been selected for high (H) or low (L) combined antibody and cell-mediated immune response to test the high immune response phenotype as a candidate for an indirect approach to improving health and productivity in livestock. Mycoplasma hyorhinis infection was induced in H and L pigs of the 4th generation of selection to test the hypothesis that immune response lines differ in response to infection. The major disease sign, arthritis, was more severe in the H pigs both clinically and at necropsy. M. hyorhinis was isolated at higher colony counts from synovial fluids of the H pigs. In contrast, pleuritis and peritonitis were less severe in pigs of the H than those of the L line. Pericarditis, although less in H than L pigs, did not differ significantly by line. Synovial fluid antibody to M. hyorhinis did not differ by line but H pigs produced serum antibody earlier and to a higher titre than did L pigs. Selection for H or L immune response therefore alters response to M. hyorhinis, however there is no indication of a consistent line-related health advantage.
Magnusson
U
U
Department of Veterinary Microbiology and Immunology, The University of Guelph, Ontario, Canada.
Wilkie
B
B
Mallard
B
B
Rosendal
S
S
Kennedy
B
B
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D001168:Arthritis / Q000276:immunology / Q000382:microbiology / Q000662:veterinary; D001947:Breeding; D005260:Female; D007111:Immunity, Cellular / Q000276:immunology; D008297:Male; D009174:Mycoplasma / Q000276:immunology* / Q000302:isolation & purification; D009175:Mycoplasma Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D012641:Selection, Genetic; D012700:Serositis / Q000276:immunology / Q000382:microbiology / Q000662:veterinary; D013552:Swine / Q000235:genetics / Q000276:immunology*; D013553:Swine Diseases / Q000276:immunology* / Q000382:microbiology; D013582:Synovial Fluid / Q000276:immunology / Q000382:microbiology
D000907:Antibodies, Bacterial