[Hormonal disorders in patients with chronic pyelonephritis with nephrosclerosis and kidney failure].
Blood plasma content was studied of hydrocortisone, parathyroid hormone (PTH) and calcitonin in patients with chronic pyelonephritis (ChP) using methods of radioimmunologic and immunoenzymatic analyses. ChP patients had marked alterations of blood plasma levels of hydrocortisone, PTH and calcytonin, with the reduced levels of hydrocortisone and hypercalcitoninamia being noted during the early stages of nephrosclerosis. It is suggested that hydrocortisone and calcitonin content in blood of ChP patients might be used as indicators of state of the endocrine mechanisms controlling the renal connective tissue metabolism during the early stages of nephrosclerosis. The above measure will also be helpful in the assessment of activity of the sclerotic process in the kidneys, prognosis of the outcome of the medical condition, and development of treatment options of adequate pathogenetic therapy.
Pavlov
S B
SB
D000328:Adult; D002116:Calcitonin / Q000097:blood*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009400:Nephrosclerosis / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D011704:Pyelonephritis / Q000097:blood*
D010281:Parathyroid Hormone; D002116:Calcitonin; D006854:Hydrocortisone
Gormonal'nye narusheniia u bol'nykh khronicheskim pielonefritom s nefrosklerozom i pochechnoĭ nedostatochnost'iu.