title: Major adverse reactions to yeast-derived hepatitis B vaccines--a review.
abstract: Yeast-derived recombinant DNA hepatitis B vaccines usage became widely accepted since the early 1990s. Severe adverse events have been reported infrequently in adults and rarely in infants and children given hepatitis B vaccine in the ten years which have passed since the introduction of the vaccine. Some of the data were summarized in previous review articles. Our review of the literature revealed reports of serious adverse reactions which included immediate reactions (anaphylaxis and urticaria) as well as delayed reactions, including skin, rheumatic, vasculitic (including Systemic Lupus Erythematosus and glumerulonephritis), hematologic, ophthalmologic and neurologic reactions. These cases were summarized and a pathogenetic mechanism is offered.
authors.affiliation: Israel Defense Force, Medical Corps, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Grotto
authors.forename: Y
authors.initials: Y
authors.lastname: Mandel
authors.forename: M
authors.initials: M
authors.lastname: Ephros
authors.forename: I
authors.initials: I
authors.lastname: Ashkenazi
authors.forename: J
authors.initials: J
authors.lastname: Shemer
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014614:Vaccines, Synthetic / Q000009:adverse effects*
chemical_list: D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic