[Cardiac troponin-T. Diagnostic efficacy in acute myocardial infarction. Clinical and laboratory assessment].
Cardiac troponin-T is a subunit of the myofibrillar regulatory troponintropomiosin complex, with sufficient specificity to myocardium. In normal conditions it is absent from serum and its presence indicates lesion of the cardiac cells. The authors evaluated the analytical and clinical performance of an immunoassay for cardiac troponin-T, before its introduction in their own laboratory routine. They concluded that the test had good analytical performance, with some difficulties in practicability that can be surpassed by using a rapid bedside test for troponin-T in urgency departments, already approved by FDA in USA and available in Portugal. The diagnostic specificity and sensitivity was better than the one of the classic enzymatic markers for Acute Myocardial Infarction (AMI) but it is necessary to establish clear clinical protocols that allow its use in AMI.
Miguel
M J
MJ
Serviço de Patologia Clínica, Hospital de Santa Maria, Lisboa.
Amaral
T
T
Loureiro
J
J
Brito
B
B
Pêgo
J
J
Machado
H C
HC
Gouveia
A
A
D015415:Biomarkers / Q000097:blood; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014336:Troponin / Q000097:blood*; D020107:Troponin T
D015415:Biomarkers; D014336:Troponin; D020107:Troponin T
Troponina-T cardíaca. Eficácia diagnóstica no enfarte agudo do miocárdio. Avaliação clínico laboratorial.