title: Arterial and mixed venous oxygen desaturation during incremental exercise in patients with chronic pulmonary disease.
abstract: We evaluated arterial and mixed venous oxygen desaturation during symptom-limited exercise in patients with chronic pulmonary disease. Patients were divided into five groups according to disease: [chronic pulmonary emphysema (CPE), chronic bronchitis (CB), pulmonary tuberculosis sequalae (TB-seq), fibrosing lung disease (FLD), and pulmonary vascular disease (PVD)]. There were no significant difference in the values of arterial (PaO2) and mixed venous (PvO2) oxygen tension before and at the end of exercise among the five groups, whereas absolute decreases in PvO2 were significantly larger in PVD and FLD. The changes in PvO2 were similar to the changes in the coefficient of oxygen delivery (COD) which is equal to oxygen transport divided by oxygen consumption. These results suggest that the relative decrease in oxygen transport during exercise due to the high ratio of oxygen extraction by tissues is an important factor to determine decreases in PvO2 in pulmonary hypertensive disease and fibrosing lung disease.
authors.affiliation: Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: O
authors.initials: O
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Katoh
authors.forename: N
authors.initials: N
authors.lastname: Tanabe
authors.forename: J
authors.initials: J
authors.lastname: Yasuda
authors.forename: Y
authors.initials: Y
authors.lastname: Yosida
authors.forename: T
authors.initials: T
authors.lastname: Kuriyama
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D006328:Cardiac Catheterization; D002908:Chronic Disease; D004691:Endarterectomy; D015444:Exercise / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000098:blood supply*; D008171:Lung Diseases / Q000097:blood* / Q000503:physiopathology; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D011655:Pulmonary Embolism / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D011669:Pulmonary Wedge Pressure; D014109:Total Lung Capacity; D014655:Vascular Resistance; D014692:Ventilation-Perfusion Ratio / Q000502:physiology
chemical_list: D006454:Hemoglobins