[Molecular genetic aspects of interferon induction and antiviral action].
Interferons (IFN) are cytokines with a wide range of biological activities. The most important function of IFN is associated with the induction of host resistance to viral infections. This paper discusses the well-known experimental data and the results of the authors' theoretical studies of the regularities of type 1 interferon induction and its antiviral action. The mechanisms both of interferon gene expression and transcription regulation of IFN-stimulated genes by IFNs and viruses are analyzed. The molecular mechanisms of IFN-induced resistance and the well-known strategies acquired by viruses to overcome IFN action are discussed. The authors' analyze possible regulation by IFN of its own expression and the role of IFN- and virus-induced expression of genes of antiviral response in the development of resistance to infection.
Bazhan
S I
SI
Belova
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OE
D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism* / Q000494:pharmacology; D015967:Gene Expression Regulation, Viral / Q000235:genetics; D005814:Genes, Viral / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007372:Interferons / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D008967:Molecular Biology; D012367:RNA, Viral / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics; D014158:Transcription, Genetic; D014777:Virus Diseases / Q000188:drug therapy* / Q000821:virology; D014780:Viruses / Q000187:drug effects* / Q000235:genetics
D000998:Antiviral Agents; D012367:RNA, Viral; D007372:Interferons
Molekuliarno-geneticheskie aspekty induktsii i protivovirusnogo deĭstviia interferona.