Antihepatotoxic activity of monomethyl fumarate isolated from Fumaria indica.
Monomethyl fumarate, isolated for the first time from the methanolic extract of the whole plant of Fumaria indica, was characterised and screened for its antihepatotoxic activity in albino rats. The compound showed significant (P < 0.01) antihepatotoxic activity against thioacetamide in vitro, and against hepatotoxicities induced by carbon tetrachloride, paracetamol and rifampicin in vivo to an extent almost similar to that of silymarin, a known antihepatotoxic agent.
Rao
K S
KS
Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, M.S. University of Baroda, Gujarat, India.
Mishra
S H
SH
D000082:Acetaminophen; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005650:Fumarates / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005688:Galactosamine; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008298:Maleates / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin; D012838:Silymarin / Q000008:administration & dosage / Q000494:pharmacology; D013853:Thioacetamide
D005650:Fumarates; D008298:Maleates; D010936:Plant Extracts; D012838:Silymarin; D013853:Thioacetamide; C073341:citraconic acid; D000082:Acetaminophen; D005688:Galactosamine; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D012293:Rifampin