Cryptococcal meningitis and intracranial tuberculoma in a patient with Waldenstrom's macroglobulinemia treated with fludarabine.
We report a patient with Waldenstrom's Macroglobulinemia who presented with cryptococcal meningitis followed by an intracranial tuberculoma during the 18 months period after termination of cytotoxic therapy with Fludarabine. Opportunistic infections due to intracellular organisms are extremely rare in the course of this malignancy and we review the predisposing factors of these infectious entities.
Costa
P
P
Department of Infectious Diseases, Ospedale C. Poma, Mantova, Italy.
Luzzati
R
R
Nicolato
A
A
Perboni
G
G
Scalzini
A
A
Lazzarini
L
L
Forghieri
M E
ME
Aitini
E
E
Zinzani
P L
PL
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001927:Brain Diseases / Q000209:etiology / Q000382:microbiology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016919:Meningitis, Cryptococcal / Q000209:etiology*; D008875:Middle Aged; D009894:Opportunistic Infections / Q000209:etiology* / Q000382:microbiology; D014375:Tuberculoma / Q000209:etiology*; D014740:Vidarabine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000188:drug therapy*
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D014740:Vidarabine; C024352:fludarabine