title: Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation.
abstract: c-fos and zif268 expression were assessed by immunocytochemistry for c-Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268.
authors.affiliation: Department of Oral Anatomy II, Okayama University Dental School, 2-5-1 Shikata-cho, Okayama 700, Japan. tsugi@dent.okayama-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Y F
authors.initials: YF
authors.lastname: He
authors.forename: M
authors.initials: M
authors.lastname: Funahashi
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D003782:Dental Pulp / Q000378:metabolism*; D051766:Early Growth Response Protein 1; D004558:Electric Stimulation; D005786:Gene Expression Regulation / Q000502:physiology*; D017781:Genes, Immediate-Early; D016762:Genes, fos; D017874:Immediate-Early Proteins; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D014157:Transcription Factors / Q000235:genetics*; D014278:Trigeminal Nuclei / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486110:Egr1 protein, rat; D017874:Immediate-Early Proteins; D014157:Transcription Factors