Comparison of antihemorrhagic activities in skeletal muscle extracts from various animals against Bothrops jararaca snake venom.
Antihemorrhagic activities of skeletal muscle extracts from various animals were compared in inhibiting the hemorrhagic activity of Bothrops jararaca venom. The muscle extracts of the European hedgehog (Erinaceus europaeus) exhibited the strongest activity, followed by those of other insectivores such as the shrew (Crocidura russula) and mole (Talpa europaea). The antihemorrhagic activities of muscle extracts from experimental animals such as mice, rats, guinea-pigs, hamsters and rabbits were negligible.
Omori-Satoh
T
T
Research and Development Unit, Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok.
Takahashi
M
M
Nagaoka
Y
Y
Mebs
D
D
D000818:Animals; D017837:Bothrops; D006224:Cricetinae; D006168:Guinea Pigs; D006364:Hedgehogs; D006470:Hemorrhage / Q000517:prevention & control*; D051379:Mice; D008971:Moles; D018482:Muscle, Skeletal; D011817:Rabbits; D051381:Rats; D012788:Shrews; D012910:Snake Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013045:Species Specificity; D014020:Tissue Extracts / Q000627:therapeutic use*
D012910:Snake Venoms; D014020:Tissue Extracts