Regulation of megakaryocytopoiesis and platelet production: lessons from animal models.
de Sauvage
F J
FJ
Department of Molecular Oncology, Genentech Inc., South San Francisco, California 94080, USA.
Villeval
J L
JL
Shivdasani
R A
RA
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000235:genetics; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D008533:Megakaryocytes / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins / Q000502:physiology; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; D013926:Thrombopoietin / Q000502:physiology / Q000627:therapeutic use
D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; C082218:MPL protein, human; D013926:Thrombopoietin