[Novel mathematical approach to determination of antibiotics concentration by agar diffusion method. Analysis of graphical, table and mathematical options of relative biological activity estimation].
Several varieties of relative biological activity estimation are comparatively analyzed and illustrated by an example of tylosin. For visual demonstration the estimates with the equation of a straight line are represented graphically. It is concluded that the design equations in the State Pharmacopeia XI (USSR) should be respectively replaced. The advantages of the variety for the biological activity estimation with the one-point intercept form of the equation of a straight line are illustrated by particular examples.
Esipov
S E
SE
National Research Centre of Antibiotics, Moscow.
D000362:Agar; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology; D002138:Calibration; D004058:Diffusion; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data*; D015645:Tylosin / Q000032:analysis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000362:Agar; D015645:Tylosin
Novyĭ matematicheskiĭ podkhod pri opredelenii kontsentratsii antibiotikov metodom diffusii v agar. Analiz graficheskikh, tablichnykhi matematicheskikh variantov rascheta otnocitel'noĭ biologicheskoĭ aktivnosti.