A model of perinatal hypoxic-ischemic brain damage.
In conclusion, our immature rat model has gained wide acceptance as the animal model of choice to study basic physiologic, biochemical, and molecular mechanisms of perinatal hypoxic-ischemic brain damage. In addition, the model has been used extensively to study those physiologic and therapeutic variables which either are deleterious or beneficial to the perinatal brain undergoing hypoxia-ischemia. As therapeutic interventions are tested in the animal setting, the results will provide important information regarding the effect of these agents in the human setting.
Vannucci
R C
RC
Department of Pediatrics (Pediatric Neurology), Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033-0850, USA.
Vannucci
S J
SJ
D000818:Animals; D000831:Animals, Newborn; D001237:Asphyxia / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D002534:Hypoxia, Brain / Q000503:physiopathology*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000503:physiopathology*; D051381:Rats