Relationship between serum parathyroid hormone levels and lipid profile in hemodialysis patients. Evolution of lipid parameters after parathyroidectomy.
To determine the influence of parathyroid hormone (PTH) on lipid disturbances of uremia, the lipid profile was determined in 34 hemodialysis (HD) patients, comparing lipid parameters among subjects classified according to their intact PTH level. Furthermore, the effect of correction of severe secondary hyperparathyroidism on serum lipids was evaluated in 7 patients after parathyroidectomy. Total cholesterol, high-density lipoproteins (HDL), triglycerides, apolipoproteins A-I and B-100 (Apo B and Apo B), lipoprotein(a) and the ratios of cholesterol/HDL and Apo A/Apo B were analyzed. There was no correlation between serum lipids and PTH levels in the total group. Lipid profile was similar among patients classified according to their PTH level. No correlations were observed in either group between lipids and PTH. Lipid profile did not change in the seven patients with severe secondary hyperparathyroidism after parathyroidectomy. In conclusion, there was no relationship between PTH and lipids and risk ratios in HD patients. Lipid profile did not change in patients with severe secondary hyperparathyroidism after parathyroidectomy. These findings suggest that PTH does not play a significant role in the dyslipidemia of renal failure.
Navarro
J F
JF
Department of Nephrology, Hospital Ntra. Sra. de Candelaria, Madrid, Spain.
Teruel
J L
JL
Lasunción
M A
MA
Mora-Fernandez
C
C
Ortuño
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000209:etiology; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood* / Q000502:physiology; D016105:Parathyroidectomy; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood
D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008055:Lipids; D008074:Lipoproteins; D010281:Parathyroid Hormone; D014280:Triglycerides; D002784:Cholesterol