Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.
Ennis
M D
MD
Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.
Ghazal
N B
NB
Hoffman
R L
RL
Smith
M W
MW
Schlachter
S K
SK
Lawson
C F
CF
Im
W B
WB
Pregenzer
J F
JF
Svensson
K A
KA
Lewis
R A
RA
Hall
E D
ED
Sutter
D M
DM
Harris
L T
LT
McCall
R B
RB
D000818:Animals; D001578:Benzopyrans / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects; D002339:Carotid Arteries / Q000187:drug effects / Q000502:physiology; D002415:Cats; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D004388:Dura Mater / Q000098:blood supply / Q000187:drug effects; D006071:Gorilla gorilla; D006168:Guinea Pigs; D007035:Hypothermia / Q000378:metabolism; D007249:Inflammation / Q000503:physiopathology; D008881:Migraine Disorders / Q000188:drug therapy*; D010879:Piperazines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D013237:Stereoisomerism; D018170:Sumatriptan / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D014655:Vascular Resistance / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity
D001578:Benzopyrans; C112854:PNU 109291; D010879:Piperazines; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D014662:Vasoconstrictor Agents; D018170:Sumatriptan