title: F-actin-binding proteins.
abstract: The study of proteins that bind filamentous actin (F-actin) is entering an exciting stage as more and more structures are determined. After more than 50 years in which the focus was on muscle proteins, emphasis has recently shifted towards understanding the complex interplay among actin-binding molecules in non-muscle cells. To date, the binding sites for eight classes of filament-binding molecules have been determined by combining low- to intermediate-resolution maps obtained by electron microscopy with atomic structures determined by X-ray crystallography and NMR. Recent results have dramatically accentuated the importance of filament geometry and actin conformation in defining these interactions.
authors.affiliation: Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA. amcgough@bcm.tmc.edu
authors.forename: A
authors.initials: A
authors.lastname: McGough
mesh_terms: D051339:Actin Depolymerizing Factors; D000199:Actins / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism*; D003432:Cross-Linking Reagents; D018360:Crystallography, X-Ray; D018260:Gelsolin / Q000737:chemistry / Q000378:metabolism; D046911:Macromolecular Substances; D008840:Microfilament Proteins / Q000737:chemistry* / Q000378:metabolism*; D008854:Microscopy, Electron; D008958:Models, Molecular; D009119:Muscle Contraction / Q000502:physiology; D011485:Protein Binding
chemical_list: D051339:Actin Depolymerizing Factors; D000199:Actins; D002352:Carrier Proteins; D003432:Cross-Linking Reagents; C034037:F-actin-binding proteins; D018260:Gelsolin; D046911:Macromolecular Substances; D008840:Microfilament Proteins