Xylitol-induced increase in the plasma concentration and urinary excretion of uridine and purine bases.
To determine whether xylitol increases the plasma concentration and urinary excretion of uridine together with purine bases, we administered xylitol (0.6 g/kg weight) intravenously to six normal subjects using a 10% xylitol solution. Xylitol infusion increased the plasma concentration and urinary excretion of uridine, as well as purine bases, while it decreased both the concentrations of inorganic phosphate in plasma and pyruvic acid in blood and increased the blood concentration of lactic acid. These results suggest that an increase in the plasma concentration and urinary excretion of uridine is ascribable to increased pyrimidine degradation following purine degradation induced by xylitol.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Moriwaki
Y
Y
Takahashi
S
S
Tsutsumi
Z
Z
Yamakita
J
J
Nakano
T
T
Hiroishi
K
K
Higashino
K
K
D000328:Adult; D006801:Humans; D019271:Hypoxanthine / Q000097:blood / Q000652:urine; D007275:Injections, Intravenous; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010710:Phosphates / Q000097:blood; D011687:Purines / Q000097:blood* / Q000652:urine*; D019289:Pyruvic Acid / Q000097:blood; D014527:Uric Acid / Q000097:blood / Q000652:urine; D014529:Uridine / Q000097:blood* / Q000652:urine*; D019820:Xanthine / Q000097:blood / Q000652:urine; D014993:Xylitol / Q000097:blood / Q000494:pharmacology*
D010710:Phosphates; D011687:Purines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D019344:Lactic Acid; D019289:Pyruvic Acid; D014993:Xylitol; D014529:Uridine