title: Restoration of voluntary emptying of the bladder by transplantation of innervated free skeletal muscle.
abstract: BACKGROUND
  On the basis of studies with animals and experience with functioning muscle transfer in plastic surgery, we have developed a surgical technique to restore detrusor function for patients with bladder acontractility in whom there is no treatment alternative.
  
  
  METHODS
  Three patients (aged 26 years, 28 years, and 68 years) with bladder acontractility as a result of spinal-cord injury (two patients) and chronic overdistension (one patient), who required catheterisation for bladder emptying for 5 years, 2 years, and 2 years, respectively, took part in our study. The patients were treated with microneurovascular free transfer of autologous latissimus dorsi muscle to the bladder to restore detrusor function. Follow-up included clinical and urodynamic evaluation, colour doppler sonography, intravenous urography, and flow-mode computerised tomography.
  
  
  RESULTS
  The three patients voluntarily emptied their bladders at 16 weeks, 16 weeks, and 30 weeks after surgery, respectively. There was no need for further catheterisation throughout the follow-up period. On urodynamic assessment at 12 months after the operation bladder capacity was found to be 600 mL, 600 mL, and 650 mL, residual urinary volume 0 mL, 50 mL, 90 mL, and maximum flow rate 26 mL/s, 25 mL/s, and 18 mL/s, respectively. Activity at the transplanted latissimus dorsi was confirmed by ultrasonography and flow-mode computerised tomography.
  
  
  CONCLUSIONS
  Microneurovascular free transfer of latissimus dorsi muscle to functionally restore a deficient detrusor muscle has proved to be successful for the three patients in our study. This technique may also be an option to restore the function of other smooth-muscle organs.
authors.affiliation: Department of Urology, University of Innsbruck Medical Centre, Austria. arnulf.stenzl@uibk.ac.at
authors.forename: A
authors.initials: A
authors.lastname: Stenzl
authors.forename: M
authors.initials: M
authors.lastname: Ninkovic
authors.forename: D
authors.initials: D
authors.lastname: Kölle
authors.forename: R
authors.initials: R
authors.lastname: Knapp
authors.forename: H
authors.initials: H
authors.lastname: Anderl
authors.forename: G
authors.initials: G
authors.lastname: Bartsch
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D013119:Spinal Cord Injuries / Q000150:complications; D013524:Surgical Flaps / Q000294:innervation; D001743:Urinary Bladder / Q000503:physiopathology* / Q000601:surgery*; D001750:Urinary Bladder, Neurogenic / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D014546:Urinary Catheterization; D014554:Urination / Q000502:physiology; D014563:Urodynamics