title: Anti-inflammatory effect of hamamelis lotion in a UVB erythema test.
abstract: BACKGROUND
  Although Hamamelis virginiana has long been used in the traditional treatment of skin diseases, there are few controlled clinical studies defining the extent of its anti-inflammatory action.
  
  
  OBJECTIVE
  The anti-inflammatory efficacy of pH5 Eucerin aftersun lotion with 10% hamamelis distillate, the vehicle and a prior aftersun formulation were tested in 30 healthy volunteers using a modified UVB erythema test as model of inflammation.
  
  
  METHODS
  Four UVB doses ranging from 1 to 2 MED were evaluated in each subject. Test fields on the back were treated occlusively for 48 h following irradiation. Chromametry and visual scoring were used to determine the degree of erythema in the treated fields and an untreated, irradiated control field 7, 24 and 48 h after irradiation.
  
  
  RESULTS
  Erythema suppression ranged from approximately 20% of 7 h to 27% at 48 h in the hamamelis fields. A suppression of 11-15% was recorded in the fields treated with the other lotions. Significant differences were noted between hamamelis and these lotions.
  
  
  CONCLUSIONS
  These data provide evidence for an anti-inflammatory action of the aftersun lotion with 10% hamamelis and support the usefulness of the UVB erythema test with multiple UV doses for the testing of nonsteroidal anti-inflammatory agents.
authors.affiliation: BioSkin, Institute for Dermatological Research and Development, Hamburg, Germany. BHughes@BioSkin.de
authors.forename: B J
authors.initials: BJ
authors.lastname: Hughes-Formella
authors.forename: K
authors.initials: K
authors.lastname: Bohnsack
authors.forename: F
authors.initials: F
authors.lastname: Rippke
authors.forename: G
authors.initials: G
authors.lastname: Benner
authors.forename: M
authors.initials: M
authors.lastname: Rudolph
authors.forename: I
authors.initials: I
authors.lastname: Tausch
authors.forename: J
authors.initials: J
authors.lastname: Gassmueller
mesh_terms: D000328:Adult; D004890:Erythema / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008055:Lipids; D008297:Male; D008875:Middle Aged; D009823:Ointment Bases / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D012016:Reference Values; D016896:Treatment Outcome; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D008055:Lipids; D009823:Ointment Bases; D010936:Plant Extracts; C039909:eucerin