title: The topographic distribution of the first sites of diabetic retinal neovascularization.
abstract: OBJECTIVE
  To examine the topographic distribution of the origin of diabetic retinal neovascularization.
  
  
  METHODS
  The eyes of 3,121 patients with background diabetic retinopathy were investigated. These patients were volunteers in systemic medical therapy experiments. Color stereo photographs were obtained annually. The first retinal neovascularization sites were identified and the distances from the optic nerve measured.
  
  
  RESULTS
  In 1 year, neovascularization originated in 282 eyes. The superotemporal quadrant, at 6 mm from the optic disk, was the most frequent initial site.
  
  
  CONCLUSIONS
  The first retinal neovascularization sites cluster around specific anatomic foci. This information should influence retinopathy monitoring protocols.
authors.affiliation: Department of Ophthalmology and Visual Sciences (Fundus Photo Reading Center), School of Medicine, Vanderbilt University, Nashville, TN 37232-8808, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Feman
authors.forename: T C
authors.initials: TC
authors.lastname: Leonard-Martin
authors.forename: T M
authors.initials: TM
authors.lastname: Semchyshyn
mesh_terms: D002986:Clinical Trials as Topic; D003930:Diabetic Retinopathy / Q000150:complications / Q000473:pathology*; D006801:Humans; D010781:Photography; D012160:Retina / Q000473:pathology*; D015861:Retinal Neovascularization / Q000209:etiology / Q000473:pathology*; D014794:Visual Fields