[Immobilizing muscle weakness accentuated in leg and proximal muscles].
A 54 year old waiter was referred to the hospital because of proximal muscle weakness, most pronounced in his legs, which progressed to an inability to stand or walk within weeks. Myopathy was diagnosed based on the muscle biopsy findings and myositis was ruled out by laboratory and biopsy results. Further investigations led us to exclude an endocrine cause, hypovitaminosis D, infectious myopathy or a paraneoplastic syndrome. Heteroanamnesis revealed severe alcoholism, lasting for more than 30 years. The presumed alcohol induced hepatopathy was confirmed by liver biopsy. There were no signs of an acute alcoholic myopathy, as the weakness had developed rather insidiously, there was no elevation of the CK serum level nor myoglobinuria and a type 2 fibre atrophy was found by muscle biopsy. As expected the weakness improved under abstention. Thus the final diagnosis of a chronic alcohol induced myopathy was established.
Wuttke
M
M
Medizinische Klinik, Stadtspital Waid, Zürich.
Meyer
M
M
Varga
Z
Z
Stoll
T
T
D000437:Alcoholism / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D006519:Hepatitis, Alcoholic / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007866:Leg; D008099:Liver / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D009133:Muscular Atrophy / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology
Immobilisierende bein- und proximalbetonte Muskelschwäche.