Nitric oxide inhibits proliferation but increases life-span of T lymphocytes in tumour-bearing rats.
Nitric oxide (NO) has been shown to inhibit the proliferation of lymphocytes. However, in tumour-bearing rats treated with the immunomodulator OM 163, the regressing nodules were heavily infiltrated by T lymphocytes, although they contained high levels of NO. We show here that NO, while inhibiting the proliferation of lymphocytes, increased their life-span, pointing to the ambivalence of this molecule in the course of tumour growth and regression.
Reisser
D
D
Ecole Pratique des Hautes Etudes, Cancer Immunotherapy Research Laboratory, Faculty of Medicine, Dijon, France.
Lagadec
P
P
Arnould
L
L
Onier
N
N
Maupoil
V
V
Pinard
D
D
Jeannin
J F
JF
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002277:Carcinoma / Q000276:immunology / Q000628:therapy; D002470:Cell Survival / Q000187:drug effects; D004926:Escherichia coli; D007167:Immunotherapy; D008213:Lymphocyte Activation / Q000187:drug effects; D009569:Nitric Oxide / Q000096:biosynthesis / Q000494:pharmacology*; D010534:Peritoneal Neoplasms / Q000276:immunology / Q000628:therapy; D051381:Rats; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D009569:Nitric Oxide