The interleukin-17 gene of herpesvirus saimiri.
In comparison to wild-type herpesvirus saimiri, viral interleukin-17 gene knockout mutants have unaltered behavior regarding viral replication, T-cell transformation in vitro, and pathogenicity in cottontop tamarins. Thus, this gene is not required for T-cell lymphoma induction but may contribute to apathogenic viral persistence in the natural host, the squirrel monkey.
Knappe
A
A
Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany.
Hiller
C
C
Niphuis
H
H
Fossiez
F
F
Thurau
M
M
Wittmann
S
S
Kuhn
E M
EM
Lebecque
S
S
Banchereau
J
J
Rosenwirth
B
B
Fleckenstein
B
B
Heeney
J
J
Fickenscher
H
H
D000818:Animals; D005814:Genes, Viral; D006567:Herpesvirus 2, Saimiriine / Q000235:genetics*; D020381:Interleukin-17; D007378:Interleukins / Q000235:genetics*; D008213:Lymphocyte Activation; D012452:Saguinus; D013601:T-Lymphocytes / Q000276:immunology; D014779:Virus Replication
D020381:Interleukin-17; D007378:Interleukins