title: The effect of intraoperative ventilation strategies on perioperative atelectasis.
abstract: Several methods of ventilation have previously been shown to reduce intraoperative atelectasis and alveolar to arterial oxygen gradient (A-a DO2) in healthy patients. This study was designed to show firstly the relative intra-operative benefit and secondly if any method had an effect on atelectasis postoperatively. Using a factorial design we randomized 24 patients to each of the four ventilatory interventions (manual inflations, large tidal volumes, PEEP, and pressure control inverse ratio ventilation (IRV)). The A-a DO2 was used as the measure of atelectasis and data collected intra- and postoperatively for 24 hours. The mean pre-induction A-a DO2 was 80 mmHg. This study demonstrated that PEEP and IRV were most effective in reducing intraoperative A-a DO2 (P < 0.05 ANCOVA). Using more than one intervention did not improve the A-a DO2. No method had any effect on postoperative A-a DO2.
authors.affiliation: Department of Anaesthetics, Waikato Hospital, Hamilton, New Zealand.
authors.forename: J P
authors.initials: JP
authors.lastname: Clarke
authors.forename: M N
authors.initials: MN
authors.lastname: Schuitemaker
authors.forename: J W
authors.initials: JW
authors.lastname: Sleigh
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D011184:Postoperative Period; D011650:Pulmonary Alveoli / Q000502:physiology; D001261:Pulmonary Atelectasis / Q000517:prevention & control*; D012121:Respiration, Artificial / Q000379:methods*