title: Helicobacter pylori colonization density and gastric acid output in non-ulcer dyspepsia and duodenal ulcer disease.
abstract: BACKGROUND
  The pattern of intragastric Helicobacter pylori colonization and its density may be determined by parietal cell function. H. pylori bacterial products can inhibit gastric acid secretion from the parietal cell. The aim of this investigation was to study the relationship between acid output and intragastric H. pylori distribution and colonization density in duodenal ulcer (DU) and non-ulcer subjects. The study included 14 patients with active DU, 10 with inactive DU and 10 non-ulcer dyspeptics.
  
  
  METHODS
  Acid output studies in response to fasting and maximal pentagastrin stimulation, basal (BAO) and peak (PAO) acid outputs were calculated. A quantitative assessment of H. pylori colonization density in biopsies from five sites of the gastroduodenum in the active ulcer group, and from the antrum in inactive duodenal ulcer and non-ulcer groups.
  
  
  RESULTS
  There were negative correlations between total gastroduodenal bacterial colonization density and, PAO (r - 0.87, p = 0.0025) and BAO (r - 0.635, p < 0.02) in the active ulcer group. There were negative correlations between antral H. pylori colonization density and PAO in the active duodenal ulcer (r - 0.7449, p < 0.01) and non-ulcer (r - 0.5837, p < 0.1) groups but not in the inactive duodenal ulcer group (r - 0.1869, p > 0.2).
  
  
  CONCLUSIONS
  An equilibrium is reached between gastroduodenal H. pylori colonization density and gastric acid secretory capacity in active duodenal ulcer disease. It is hypothesized that thresholds of bacterial load and acid secretory capacity, in combination, are required for active ulceration in DU disease.
authors.affiliation: Department of Medicine, Southampton University Hospitals, U.K.
authors.forename: P D
authors.initials: PD
authors.lastname: Mullins
authors.forename: H W
authors.initials: HW
authors.lastname: Steer
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D004381:Duodenal Ulcer / Q000378:metabolism* / Q000382:microbiology*; D004415:Dyspepsia / Q000378:metabolism* / Q000382:microbiology*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric