[Chronic relapsing experimental allergic encephalomyelitis in Lewis rats as a model of multiple sclerosis].
Chronic relapsing experimental allergic encephalomyelitis (CR EAE) was induced in Lewis rats by inoculation with guinea-pig myelin and complete Freund's aduvant followed by treatment with low dose cyclosporin A. Histological, histochemical and electron microscopic studies of the lesions during the first and the second clinical episodes, as well as during the first and the second remissions, revealed inflammation, prominent demyelination, remyelination and gliosis in the central nervous system (CNS). This model of CR EAE in the Lewis rats may be a useful model for multiple sclerosis.
Zaprianova
E
E
Institute of Experimental Morphology, Bulgarian Academy of Sciences, Sofia.
Deleva
D
D
Bakalska
M
M
Filchev
N
N
D000818:Animals; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008161:Lumbosacral Region; D009103:Multiple Sclerosis / Q000473:pathology*; D051381:Rats; D011917:Rats, Inbred Lew; D011921:Rats, Inbred WKY; D012008:Recurrence; D013116:Spinal Cord / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine
Khronicheskiĭ remittiruiushchiĭ éksperimental'nyĭ allergicheskiĭ éntsefalomielit u krys Lewis kak model' rasseinnogo skleroza.