title: The porcine acute phase response to infection with Actinobacillus pleuropneumoniae. Haptoglobin, C-reactive protein, major acute phase protein and serum amyloid A protein are sensitive indicators of infection.
abstract: In an experimental infection model mimicking acute Actinobacillus pleuropneumoniae (Ap) infection in swine (Sus scrofa) by aerosol inoculation, the development of a number of typical clinical signs was accompanied by a prototypic acute phase reaction encompassing fever and an acute phase protein response peaking at around 2 days after infection. Haptoglobin, C-reactive protein (CRP), and major acute phase protein (MAP) responded with large increases in serum levels, preceding the development of specific antibodies by 4-5 days. Serum amyloid A protein (SAA) was also strongly induced. The increase, kinetics of induction and normalization were different between these proteins. It is concluded that experimental Ap-infection by the aerosol route induces a typical acute phase reaction in the pig, and that pig Hp, CRP, MAP, and SAA are major acute phase reactants. These findings indicate the possibility of using one or more of these reactants for the nonspecific surveillance of pig health status.
authors.affiliation: Danish Veterinary Laboratory, Copenhagen, Denmark. pmhh@svs.dk
authors.forename: P M
authors.initials: PM
authors.lastname: Heegaard
authors.forename: J
authors.initials: J
authors.lastname: Klausen
authors.forename: J P
authors.initials: JP
authors.lastname: Nielsen
authors.forename: N
authors.initials: N
authors.lastname: González-Ramón
authors.forename: M
authors.initials: M
authors.lastname: Piñeiro
authors.forename: F
authors.initials: F
authors.lastname: Lampreave
authors.forename: M A
authors.initials: MA
authors.lastname: Alava
mesh_terms: D000189:Actinobacillus Infections / Q000097:blood*; D016977:Actinobacillus pleuropneumoniae; D000209:Acute-Phase Proteins / Q000378:metabolism*; D000210:Acute-Phase Reaction; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D006242:Haptoglobins / Q000378:metabolism; D008297:Male; D012680:Sensitivity and Specificity; D000685:Serum Amyloid A Protein / Q000378:metabolism; D013552:Swine
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein