Signal transduction inhibitors, hibarimicins, A, B, C, D and G produced by Microbispora. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.
Strain TP-AO121 which produces a complex of novel tyrosine kinase inhibitors designated hibarimicins A, B, C, D and G was considered to be a new subspecies of Microbispora rosea, and the name, Microbispora rosea subsp. hibaria, was proposed. Hibarimicins A, B, C and D specifically inhibited the src tyrosine kinase activity without affecting protein kinase A or protein kinase C. They also showed in vitro anti-Gram-positive bacterial and antitumor activities. The molecular formulae of hibarimicins A, B, C, D and G were assigned to be C85H112O37, C85H112O37, C83H110O36, C85H112O38, and C85H112O39 respectively.
Kajiura
T
T
Biotechnology Research Center, Toyama Prefectural University, Japan.
Furumai
T
T
Igarashi
Y
Y
Hori
H
H
Higashi
K
K
Ishiyama
T
T
Uramoto
M
M
Uehara
Y
Y
Oki
T
T
D000192:Actinomycetales / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004271:DNA, Fungal / Q000235:genetics; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D051379:Mice; D009693:Nucleic Acid Hybridization; D047428:Protein Kinase Inhibitors; D015398:Signal Transduction / Q000187:drug effects*; D014407:Tumor Cells, Cultured; D019061:src-Family Kinases / Q000037:antagonists & inhibitors
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D004271:DNA, Fungal; D004791:Enzyme Inhibitors; D047428:Protein Kinase Inhibitors; D019061:src-Family Kinases