Effect of human alpha2-macroglobulin on proliferative activity of rat tumor cells.
The Walker carcinosarcoma cells were cultured in the medium with low concentration (0.25%) of fetal calf serum, in the presence of native or methylamine-treated (modified) human alpha 2-macroglobulin (alpha 2-MG) in vitro. The proliferative activity (3H-thymidine incorporation) of these cells increased in the presence of one or the other alpha 2-MG preparation. It allows to suppose that the human alpha 2-MG may serve as a growth-stimulating factor of tumour cells.
Mal'tseva
N V
NV
Central Research Laboratory, Postgraduate Physician Institute, Novokuznetsk.
Arkhipova
S V
SV
Zorin
N A
NA
D000818:Animals; D002296:Carcinosarcoma / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D008744:Methylamines / Q000737:chemistry*; D051381:Rats; D014407:Tumor Cells, Cultured; D000511:alpha-Macroglobulins / Q000737:chemistry / Q000494:pharmacology*
D008744:Methylamines; D000511:alpha-Macroglobulins; C027451:methylamine
Vliianie alpha2-makroglobulina cheloveka na proliferativnuiu opukholevykh kletok krys]