title: The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease.
abstract: The importance of apolipoproteins in the central nervous system became increasingly clear with the association in 1993 of the epsilon4 allele of apolipoprotein E with familial and sporadic late-onset Alzheimer's disease. Apolipoprotein E is a ligand for several receptors, most of which are found to some extent in the brain. This review summarizes the various apolipoproteins and lipoprotein receptors found in the brain. A growing body of evidence now implicates irregular lipoprotein metabolism in several neurodegenerative disorders. We then focus on research linking apolipoprotein E and Alzheimer's disease, from clinical studies to biochemical models, which may explain some of the complex neurobiology of this disorder.
authors.affiliation: Department of Neurology and Neurosurgery, McGill University, Montreal, PQ, Canada.
authors.forename: U
authors.initials: U
authors.lastname: Beffert
authors.forename: M
authors.initials: M
authors.lastname: Danik
authors.forename: P
authors.initials: P
authors.lastname: Krzywkowski
authors.forename: C
authors.initials: C
authors.lastname: Ramassamy
authors.forename: F
authors.initials: F
authors.lastname: Berrada
authors.forename: J
authors.initials: J
authors.lastname: Poirier
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D053327:Apolipoprotein E4; D001053:Apolipoproteins / Q000378:metabolism*; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D001253:Astrocytes / Q000502:physiology; D001921:Brain / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009474:Neurons / Q000502:physiology; D011110:Polymorphism, Genetic; D018110:Receptors, Lipoprotein / Q000378:metabolism*
chemical_list: D053327:Apolipoprotein E4; D001053:Apolipoproteins; D001057:Apolipoproteins E; D018110:Receptors, Lipoprotein