title: Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets.
abstract: Functional porcine islets, free of known pathogens, can serve as a source of insulin producing cells for the treatment of experimentally induced insulin dependent Diabetes Mellitus. Porcine islets can be conformally coated (microencapsulated) with a covalently linked, stable permselective membrane while maintaining islet viability and function. The PEG conformal coating is immunoprotective in a discordant xenograft animal model (porcine islets to rat).
authors.affiliation: Neocrin Company, Irvine, California 92718, USA. rshill@neocrin.com
authors.forename: R S
authors.initials: RS
authors.lastname: Hill
authors.forename: G M
authors.initials: GM
authors.lastname: Cruise
authors.forename: S R
authors.initials: SR
authors.lastname: Hager
authors.forename: F V
authors.initials: FV
authors.lastname: Lamberti
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.forename: C L
authors.initials: CL
authors.lastname: Garufis
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: K E
authors.initials: KE
authors.lastname: Mundwiler
authors.forename: J F
authors.initials: JF
authors.lastname: Cole
authors.forename: J A
authors.initials: JA
authors.lastname: Hubbell
authors.forename: O D
authors.initials: OD
authors.lastname: Hegre
authors.forename: D W
authors.initials: DW
authors.lastname: Scharp
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002214:Capsules; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000379:methods*; D008567:Membranes, Artificial; D019397:Pancreas, Artificial; D010777:Photochemistry; D011092:Polyethylene Glycols; D051381:Rats; D013552:Swine; D014181:Transplantation Immunology
chemical_list: D001672:Biocompatible Materials; D002214:Capsules; D008567:Membranes, Artificial; D011092:Polyethylene Glycols