High levels of soluble IFN gamma receptor alpha chain in the plasma of rheumatoid arthritis patients.
Soluble receptors for hormones and cytokines have been described. They can serve as natural blockers of their respective ligands. The natural soluble interferon gamma receptor (sIFN gamma R) has been isolated and characterized only in urine. Chromatography of human (hu) plasma from rheumatoid arthritis (RA) patients and controls on immobilized hu IFN gamma or antibodies against IFN gamma R alpha chain permitted us to isolate the sIFN gamma R. The receptor isolated from one control is a protein with a molecular weight between 60-67 kDa depending on the presence of reducing agents. We detected a significantly higher level of plasma sIFN gamma R in patients with rheumatoid arthritis than in apparently healthy subjects.
Bello
I
I
Centro de Investigaciones Biologicas, Havana, Cuba.
Perez
A
A
Torres
A M
AM
Hernández
M V
MV
López Saura
P
P
D001172:Arthritis, Rheumatoid / Q000097:blood*; D006801:Humans; D046911:Macromolecular Substances; D008970:Molecular Weight; D017471:Receptors, Interferon / Q000097:blood*; D012995:Solubility; D000096743:Interferon gamma Receptor
D046911:Macromolecular Substances; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor