[The effect of nootropic agents on brain mitochondrial function in the dynamics of craniocerebral trauma from the age aspect].
A craniocerebral trauma was modelled in experiments on one-month-old rats. Oxidative phosphorylation in the brain mitochondria was studied by polarography 1, 4, 7 days and 4 weeks after the trauma. In the posttraumatic period the animals received piracetam (1 g/kg), picamilon (500 mg/kg), pyriditol (100 mg/kg), pantogam (160 mg/kg), ACTH (5-10) (0.1 mg/kg), nooglutyl (25 mg/kg), and GVS (0.5 mg/kg). It was found that piracetam, picamilon, and nooglutyl have a protective effect on the function of the brain mitochondria during the course of a craniocerebral trauma. Nooglutyl surpasses all the other drugs in its influence on the effectiveness of oxidative phosphorylation of mitochondria in immature rats in the posttraumatic period.
Novikov
V E
VE
Smolensk Medical Academy, Russia.
Kovaleva
L A
LA
D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001930:Brain Injuries / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D018697:Nootropic Agents / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D018697:Nootropic Agents
Vliianie nootropov na funktsiiu mitokhondriĭ mozga v dinamike cherepno-mozgovoĭ travmy v vozrastnom aspekte.