Complement and complement inhibitors: their role in autoimmune and inflammatory diseases.
The role of complement in the pathogenesis of renal injury is now being confirmed with the use of knockout technology and specific inhibitors. Chronic injury, particularly of the tubules and interstitium, and local complement synthesis are emerging as potential additional targets for complement-based therapy. Strategies are being developed to prevent complement-induced injury both in transplant and in native kidneys.
Sheerin
N S
NS
Department of Nephrology and Transplantation, United Medical and Dental School, Guy's Hospital, London, UK.
Sacks
S H
SH
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology*; D003169:Complement Inactivator Proteins / Q000502:physiology*; D003165:Complement System Proteins / Q000502:physiology*; D006801:Humans; D007239:Infections / Q000209:etiology; D007249:Inflammation / Q000209:etiology*; D007668:Kidney / Q000276:immunology / Q000293:injuries; D007674:Kidney Diseases / Q000209:etiology; D016030:Kidney Transplantation
D003169:Complement Inactivator Proteins; D003165:Complement System Proteins