[Ultrastructural changes in afferent mixed synapses in long-term potentiation of electrotonic responses in Mauthner neurons of goldfish medulla oblongata].
Ultrastructural synaptic features of long-term potentiation (double increase of amplitude) of electrotonic responses of the goldfish Mauthner neurons (MN) in conditions of prolonged in vitro incubation of medulla oblongata fragments were studied. Potentiation was induced by tetanization of the 8th nerve posterior roots, axonal terminals of which end on distal segments of MN lateral dendrite as piniform mixed synapses and increase their electrotonic conductivity. It was established that potentiated synapses vary from control ones in 1) greater length of synaptic contact; 20 greater (30% higher) ratio of desmosome like structures (DLS); 3) greater area of the DLS individual and total sections (two-fold increase); 4) two-fold decrease of total active zone square. Gap junction (GJ) parameters did not change. Taking an account of the proven actin origin of DLS, reports on actin filaments electron conductivity, close localization of DLS and GJ in the synaptic contact and correlative increase of synapse electric conductivity and DLS parameters. DLS contribution to electrotonic transmission is suggested, direct or mediated by actin interaction with nearby localized GJ connexons.
Moshkov
D A
DA
Laboratory of Neuron Ultrastructure, Russian Academy of Sciences, Puschino Moscow district.
Tiras
N R
NR
Pavlik
L L
LL
Mukhttasimova
N F
NF
Pakhorina
I D
ID
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001931:Brain Mapping; D017629:Gap Junctions / Q000502:physiology; D006054:Goldfish / Q000502:physiology*; D017774:Long-Term Potentiation; D008526:Medulla Oblongata / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure
Ul'trastrukturnye izmeneniia afferentnykh smeshannykh sinapsov pri dolgovremennoĭ potentsiatsii élektrotonicheskikh otvetov maytnerovskikh neĭronov v inkubirovannykh fragmentakh prodolgovatogo mozga zolotĭ rybki.