title: Anesthetic management of a patient with myasthenia gravis during hypothermic cardiopulmonary bypass.
abstract: The anesthetic management of a patient with myasthenia gravis (MG) who underwent cardiac surgery with hypothermic cardiopulmonary bypass (CPB) is described. Using total intravenous anesthesia with propofol and a moderate dose fentanyl, the variations of neuromuscular function and serum anti-acetylcholine receptor antibody concentration were examined in relation to hypothermic CPB in the absence of muscle relaxants. The anesthetic technique used may have helped to avoid the risks incidental to muscle relaxants in this patient with MG undergoing hypothermic CPB.
authors.affiliation: Department of Anesthesiology, University of Occupational and Environmental Health School of Medicine, Japan, Kitakyushu City.
authors.forename: H
authors.initials: H
authors.lastname: Ishimura
authors.forename: T
authors.initials: T
authors.lastname: Sata
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: A
authors.initials: A
authors.lastname: Takizuka
authors.forename: A
authors.initials: A
authors.lastname: Shigematsu
mesh_terms: D000368:Aged; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000906:Antibodies / Q000097:blood; D002315:Cardiopulmonary Bypass; D000075202:Contraindications; D001026:Coronary Artery Bypass; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009157:Myasthenia Gravis / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D009465:Neuromuscular Agents; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D015742:Propofol / Q000008:administration & dosage*; D011950:Receptors, Cholinergic / Q000276:immunology; D012307:Risk Factors; D009435:Synaptic Transmission / Q000187:drug effects; D013934:Thymectomy
chemical_list: D018686:Anesthetics, Intravenous; D000906:Antibodies; D009465:Neuromuscular Agents; D011950:Receptors, Cholinergic; D005283:Fentanyl; D015742:Propofol