[Results of immunogenetic typing of lymphocytes of patients with keratoconus].
Histotyping of HLA I antigens in 100 patients with keratoconus. Europeoids of the Chelyabinsk district, and of 701 controls (donors listed in the regional register) showed an increased incidence of HLA A28, B12, and B15, a decreased incidence of HLA B8, B13, and complete absence of HLA A11. Estimation of HLA haplotypes in keratoconus showed an increased incidence of haplotypes A1-B5 (relative risk RR = 5.9), A2-B15 (RR = 3.34), A2-B27 (RR = 2.12), and A9-B21 (RR = 4.13) and decreased incidence of A1-B8 (RR = 0.31). The incidence of incomplete phenotypes was 27%. The most incident of incomplete phenotypes was A3-B35. Reliably linked HLA haplotypes A3-B7, A2-B27, A9-B21, and A9-B35 were typical of men with keratoconus, whereas A2-B21 haplotype was characteristic of the female patients.
Gorskova
E N
EN
Tarasova
L N
LN
Teplova
S N
SN
Sevost'ianov
E N
EN
D000328:Adult; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006239:Haplotypes; D006801:Humans; D007640:Keratoconus / Q000235:genetics* / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008962:Models, Theoretical; D010641:Phenotype
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens
Rezul'taty immunogeneticheskogo tipirovaniia limfotsitov bol'nykh keratokonusom.