Synthesis, lipophilicity and antimicrobial properties of some O-(5-aryl-1,2,4-triazol-3-yl-ethyl)benzaldoximes and O-(5-aryl-1,3,4-oxydiazol-2-yl-ethyl)benzaldoximes.
The synthesis of benzaldehyde oximethers with suitably substituted 1,2,4-triazoles and 1,3,4-oxadiazoles from the corresponding benzaldoximes is described. The lipophilicity of the compounds was measured as well as their antimicrobial and antifungal activity in vitro. Certain compounds showed relatively significant activity against Bacillus subtilis.
Papakonstantinou-Garoufalias
S
S
Department of Pharmacy, University of Athens, Greece.
Marakos
P
P
Tsantili-Kakoulidou
A
A
Chytyroglou-Ladas
A
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008055:Lipids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D008055:Lipids; D010069:Oxadiazoles; D010091:Oximes; D014230:Triazoles