title: Predicting detectability in radioguided surgery: a study based on physical characterization of the probe and on tissue uptake ratios of 125I-, 153Sm- and 165Er-labelled radiopharmaceuticals.
abstract: We performed measurements of the sensitivity in water of the radioguided surgery system, Neoprobe 1000. Point sources of 125I, 153Sm and 165Er were measured to a geometric accuracy of 0.1 mm. These measurements were performed with the detector uncollimated and with two different collimators; the results were used to construct three-dimensional sensitivity matrices from which isosensitivity curves could be derived. The matrices were used to simulate the reliability of detecting tumours of various sizes, at various depths, and with variable uptake ratios and activity levels of the three radionuclides investigated. Simulations showed improved tumour detection with a conical collimator, demonstrating that collimator design is important. To minimize the radiation dose during diagnostic work-up, a novel bone-seeking radiopharmaceutical, 165Er-EDTMP, was developed and tested. It showed rapid bone localization, especially in growth zones, and rapid clearance from blood and non-osseous tissues. Its biodistribution was similar to that of 153Sm-EDTMP. Based on these results and previous clinical data, the simulations predicted that lung metastases with a radius of 1 mm might be reliably detected with the Neoprobe 1000 system, if equipped with a suitable collimator.
authors.affiliation: Department of Nuclear Chemistry, University of Oslo, Blindern, Norway.
authors.forename: S P
authors.initials: SP
authors.lastname: Hassfjell
authors.forename: A
authors.initials: A
authors.lastname: Skretting
authors.forename: O S
authors.initials: OS
authors.lastname: Bruland
authors.forename: P
authors.initials: P
authors.lastname: Hoff
mesh_terms: D000818:Animals; D001692:Biological Transport; D001859:Bone Neoplasms / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics*; D011237:Predictive Value of Tests; D011868:Radioisotopes / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D012493:Samarium / Q000493:pharmacokinetics; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C113297:europium ethylenediaminetetramethylenephosphonate; D012493:Samarium; C061972:samarium Sm-153 lexidronam