title: [Angiogenesis and neoangiogenesis].
abstract: Angiogenesis, the development of new capillary networks from the normal vasculature, is a fundamental process during embryogenesis. In adulthood, angiogenesis contributes to corpus luteum formation, placental implantation and wound healing and is also required in some pathological conditions such as several intraocular syndromes, growth of solid tumors, and metastasis. Many factors are involved in the regulation of neovascularisation among which FGF-2 (fibroblast growth factor-2) and VEGF (vascular endothelial growth factor) are considered as key inducers. Their biological activity is highly controlled by extracellular matrix components and angiostatic factors. Better understanding of the molecular mechanisms regulating angiogenesis should contribute to the development of new molecules to be used for the treatment of neovascularisation-linked diseases.
authors.affiliation: Laboratoire des facteurs de croissance et de la différenciation cellulaire Université Bordeaux I, Talence.
authors.forename: C
authors.initials: C
authors.lastname: Savona
authors.forename: S
authors.initials: S
authors.lastname: Javerzat
authors.forename: C
authors.initials: C
authors.lastname: Perollet
authors.forename: A
authors.initials: A
authors.lastname: Bikfalvi
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000378:metabolism; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000201:enzymology / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
chemical_list: D043925:Angiogenesis Inducing Agents; D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Angiogenèse et néoangiogenèse.