[Morphologic findings in liver tissue in mice after long-term administration of the herbicide fomesafan].
Administration of herbicide fomesafen and of fomesafen combined with one dose of iron to 44 mice during 3 to 14 months caused hyperplastic and preneoplastic changes in the liver tissue which had been described in experimental carcinogenesis* small groups of altered hepatocytes storing glycogen or lipids and foci of small basophilic liver cells occurred as early as after 3 months. Altered hepatocytes were found more frequently in mice getting fomesafen and iron. Later nodular hyperplasia of liver cells developed with nodes 3-20 mm in diameter which mostly consisted of altered hepatocytes with plenty of glycogen. After 12 and 14 month-lasting administration of fomesafen and fomesafen with iron, the hepatocellular carcinoma was proved in 5 mice. In 4 mice, the preneoplastic changes in liver tissue were accompanied by micronodular hyperplasia of liver cells which did not participate on the development of big nodes and hepatocellular carcinoma.
Chlumská
A
A
II. patologicko-anatomický ústav 1. LF UK a VFN, Praha.
Fakan
F
F
Krijt
J
J
D000818:Animals; D001549:Benzamides / Q000633:toxicity*; D006540:Herbicides / Q000633:toxicity*; D007501:Iron / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
D001549:Benzamides; D006540:Herbicides; D007501:Iron; C088563:fomesafen
Morfologické nálezy v jaterní tkáni mysí po dlouhodobém podávání herbicidu fomesafenu.