Trimeric G alpha beta gamma protein coupling to a 3D model of G protein-coupled receptors confirming a new molecular mechanism for activation.
The present-day model for G protein activation and the associated theory on how a G protein-coupled receptor may activate the G protein are summarized. Experimental data are outlined which seem not to be in accordance with this present-day model. An alternative molecular mechanism for ternary complex activation is presented together with a three-dimensional model for a receptor coupled to the appropriate trimeric G protein. This 3D structure confirms our new molecular mechanism of activation.
Nederkoorn
P H
PH
Leiden/Amsterdam Center for Drug Research (LACDR), Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, The Netherlands.
Davies
R H
RH
Timms
D
D
Timmerman
H
H
D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000096:biosynthesis; D008958:Models, Molecular; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000378:metabolism
D011956:Receptors, Cell Surface; D006160:Guanosine Triphosphate; D019204:GTP-Binding Proteins