title: Marchiafava-Bignami disease: reversibility of neuroimaging abnormality.
abstract: Marchiafava-Bignami disease (MBD) was diagnosed in a malnourished 43-year-old patient with chronic alcoholism, severe generalized extrapyramidal rigid syndrome, and severe dyspraxia. Cranial CT and MRI demonstrated isolated lesions in the geno and splenium of the corpus callosum (CC) characteristic for MBD. On thiamine therapy, a slow but steady recovery of clinical symptoms occurred, and serial CT and MRI studies demonstrated marked reversibility of abnormalities in the CC. Besides clinical improvement with a good functional outcome, reversal of CT and MRI abnormalities may occur in MBD.
authors.affiliation: Neurologische Universitätsklinik, Klinikum Mannheim, Universität Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Gass
authors.forename: G
authors.initials: G
authors.lastname: Birtsch
authors.forename: M
authors.initials: M
authors.lastname: Olster
authors.forename: A
authors.initials: A
authors.lastname: Schwartz
authors.forename: M G
authors.initials: MG
authors.lastname: Hennerici
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000473:pathology*; D000547:Amantadine / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000188:drug therapy / Q000473:pathology; D001927:Brain Diseases / Q000188:drug therapy / Q000473:pathology; D003337:Corpus Callosum / Q000187:drug effects / Q000473:pathology*; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000473:pathology*; D015259:Dopamine Agents / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000473:pathology; D009127:Muscle Rigidity / Q000473:pathology; D009748:Nutrition Disorders / Q000473:pathology*; D012074:Remission Induction; D013577:Syndrome; D013831:Thiamine / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D015259:Dopamine Agents; D014803:Vitamin B Complex; D000547:Amantadine; D013831:Thiamine