Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro.
We evaluated the effect of roxithromycin on cytokine production and neutrophil attachment to human airway epithelial cells. Roxithromycin suppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-macrophage colony-stimulating factor. It inhibited neutrophil adhesion to epithelial cells. Roxithromycin modulates local recruitment and activation of inflammatory cells, which may have relevance to its efficacy in airway diseases.
Kawasaki
S
S
Department of Medicine, School of Medicine, University of Tokyo, Japan.
Takizawa
H
H
Ohtoshi
T
T
Takeuchi
N
N
Kohyama
T
T
Nakamura
H
H
Kasama
T
T
Kobayashi
K
K
Nakahara
K
K
Morita
Y
Y
Yamamoto
K
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis / Q000187:drug effects*; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000187:drug effects; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects / Q000378:metabolism; D015850:Interleukin-6 / Q000096:biosynthesis / Q000378:metabolism; D016209:Interleukin-8 / Q000096:biosynthesis / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D015575:Roxithromycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D018799:Intercellular Adhesion Molecule-1; D015575:Roxithromycin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor