title: Toxic effects of deoxynivalenol on ribosomes and tissues of the spring wheat cultivars Frontana and Casavant.
abstract: The toxic effects of the Fusarium graminearum trichothecene toxin deoxynivalenol were determined on ribosomes and leaf tissues of the fusarium head blight-resistant spring wheat cultivar Frontana and the susceptible spring wheat cultivar Casavant. The use of a poly-U-directed 14C-phenylalanine and deoxynivalenol ribosome-binding assays provided evidence of resistance to the protein-synthesis inhibition effects of deoxynivalenol in the head blight-resistant cultivar Frontana. This is probably due to the existence of a mutation in the peptidyl transferase. This cultivar also exhibited resistance to the membrane-damaging properties of this toxin compared to the other cultivar. This report summarizes the evidence for various kinds of "trichothecene tolerance" mechanisms in fusarium head blight-resistant wheat genotypes.
authors.affiliation: Centre for Food and Animal Research, Agriculture Canada, Ottawa, Ontario, Canada. jdmiller@ccs.carleton.ca
authors.forename: J D
authors.initials: JD
authors.lastname: Miller
authors.forename: M A
authors.initials: MA
authors.lastname: Ewen
mesh_terms: D004573:Electrolytes / Q000378:metabolism; D005670:Fusarium / Q000737:chemistry; D011500:Protein Synthesis Inhibitors / Q000633:toxicity; D012270:Ribosomes / Q000187:drug effects*; D014255:Trichothecenes / Q000633:toxicity*; D014908:Triticum / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D004573:Electrolytes; D011500:Protein Synthesis Inhibitors; D014255:Trichothecenes; C007262:deoxynivalenol