Bone marrow transplants using unrelated donors.
HLA matching is still most important factor in bone marrow transplantation in unrelated donors, however, with the use of different and modern HLA/DNA typing techniques, it is becoming clear that many transplants have been performed with a significant degree of HLA mismatching, in particular, for HLA class I. The impact of this is in the context of donor selection, HLA matching and potential implications in the outcome of bone marrow transplantation is discussed in this paper.
Madrigal
J A
JA
The Anthony Nolan Research Institute, Department of Haematology, The Royal Free Hospital School of Medicine, London, UK. madrigal@rfhsm.ac.uk
D016026:Bone Marrow Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D014019:Tissue Donors