Effect of homocysteine and cholesterol in raising plasma homocysteine, cholesterol and triglyceride levels.
A high plasma homocysteine level is a newly regarded risk factor for coronary artery disease. We report a synergistic effect of homocysteine plus cholesterol feeding on further raising total plasma homocysteine, cholesterol and triglycerides levels than each agent alone, which further enhances the risk of coronary artery disease.
Zulli
A
A
Department of Cardiac Surgery, University of Melbourne, Austin Hospital, Heidelberg, VIC, Australia. az@austin.unimelb.edu.au
Buxton
B
B
Doolan
L
L
Liu
J J
JJ
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004338:Drug Combinations; D004357:Drug Synergism; D006710:Homocysteine / Q000097:blood*; D008715:Methionine / Q000008:administration & dosage*; D051381:Rats; D011921:Rats, Inbred WKY; D014280:Triglycerides / Q000097:blood*
D002791:Cholesterol, Dietary; D004338:Drug Combinations; D014280:Triglycerides; D006710:Homocysteine; D002784:Cholesterol; D008715:Methionine