Synergistic effects of relaxation and susceptibility in differentiation between compartmentalized and noncompartmentalized tissues.
OBJECTIVE
This study illustrates the synergistic effects of relaxation- and susceptibility-based contrast enhancement. Using a combination of gadolinium (Gd) and dysprosium (Dy) complexes and a sequence capable of taking advantage of the particular relaxation behavior of this combination, the difference between compartmentalized and noncompartmentalized regions was significantly enhanced.


METHODS
Magnetic resonance imaging of the rat kidney was performed before and immediately after the administration of a combination of Gd and Dy chelates (Gd-DTPA-BMA and Dy-DTPA-BMA).


RESULTS
The signal intensity (SI) of the renal parenchyma was reduced by 85%, whereas the collecting tubes had a 100% increase of their SI as demonstrated by a short repetition time (600 msec), long echo time (50 msec), and spin-echo sequence.


CONCLUSIONS
The high R2* effect, specific to the compartmentalized tissues, associated with the moderately high R1 and R2 developed in the remaining areas, results in an important improvement in tissue differentiation, which potentially is useful for the evaluation of pathological changes as in tubular necrosis.
Dupas
B
B
Centre Hospitalier Universitaire, Nantes, France.
Bach-Gansmo
T
T
Meflah
K
K
Muller
R N
RN
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D007668:Kidney / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage*; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051381:Rats
D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004369:Pentetic Acid; C064925:gadodiamide; D019786:Gadolinium DTPA