title: Dysregulation of apoptosis as a mechanism of liver disease: an overview.
abstract: Apoptosis is a morphologically distinct form of cell death which occurs in a wide variety of liver diseases. In this overview chapter, we review: (1) the current definitions of apoptosis; (2) the biochemical pathways effecting apoptosis; and (3) the intracellular pathways regulating apoptosis. We also describe how apoptosis is identified in the liver and review the ligand/receptor interactions which trigger hepatobiliary apoptosis. Finally, we speculate on potential therapeutic applications for modulating apoptosis in human liver diseases. This information is meant to provide a foundation for the following chapters each focused on a specific role of apoptosis in liver diseases.
authors.affiliation: Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA.
authors.forename: T
authors.initials: T
authors.lastname: Patel
authors.forename: L R
authors.initials: LR
authors.lastname: Roberts
authors.forename: B A
authors.initials: BA
authors.lastname: Jones
authors.forename: G J
authors.initials: GJ
authors.lastname: Gores
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D008107:Liver Diseases / Q000473:pathology* / Q000628:therapy