title: [Channelopathies: a genetic explanation of migraine and other paroxysmal neurologic disorders].
abstract: There is increasing evidence of involvement of genes coding for ion channels in the pathogenesis of paroxysmal neurological disorders. Recently for instance, mutations in the calcium channel gene on chromosome 19 were identified in migraine, ataxia, and epilepsy. With the current research into inherited 'channelopathies' a new approach has been established. A better understanding of the pathophysiology of paroxysmal neurological disorders may lead to new therapeutic strategies.
authors.affiliation: Afd. Neurologie, Leids Universitair Medisch Centrum, Leiden.
authors.forename: G M
authors.initials: GM
authors.lastname: Terwindt
authors.forename: R A
authors.initials: RA
authors.lastname: Ophoff
authors.forename: J
authors.initials: J
authors.lastname: Haan
authors.forename: R R
authors.initials: RR
authors.lastname: Frants
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
mesh_terms: D004827:Epilepsy / Q000235:genetics*; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008881:Migraine Disorders / Q000235:genetics*; D009069:Movement Disorders / Q000235:genetics*; D009154:Mutation; D009422:Nervous System Diseases / Q000235:genetics
chemical_list: D007473:Ion Channels
vernacular_title: Kanalopathieën: genetische verklaring voor migraine en andere paroxismale neurologische aandoeningen.