The immunodeficiency after allogeneic bone marrow transplantation in man: role of cytokines.
The effect of various cytokines including rIL-1, rIL-2, rIL-3, rIL-4, rIL-6, and growth factors including rNGF, rILGF and rEPGF on the post transplant immunodeficiency after allogeneic bone marrow transplantation was explored in 8 patients. The results show that neither cytokine alone was able to increase the proliferative capability in post transplant lymphocytes, however, when added in conjunction a significant increase in PHA driven proliferation was noted. Any significant lack of growth factors is probably not the only cause of immunodeficiency post transplant, since addition of any of these compounds did not have any influence on the lymphocyte proliferation, and so the data presented here suggest that therapeutic application of any of the investigated cytokines or growth factors to such patients is unlikely to be successful in overcoming the defects of T cell function post grafting.
Møller
J
J
Department of Internal Medicine B, University Hospital of Copenhagen at Frederiksberg, Denmark.
Dickmeiss
E
E
Jacobsen
N
N
Svejgaard
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology*; D016026:Bone Marrow Transplantation; D002455:Cell Division / Q000187:drug effects; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology*; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007938:Leukemia / Q000601:surgery*; D009000:Monocytes / Q000166:cytology / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D011183:Postoperative Complications; D011994:Recombinant Proteins; D012016:Reference Values; D014184:Transplantation, Homologous; D017211:Treatment Failure
D016207:Cytokines; D006133:Growth Substances; D010835:Phytohemagglutinins; D011994:Recombinant Proteins