Identification of an insertion sequence located in a region encoding virulence factors of Streptococcus pyogenes.
An insertion sequence, IS1562, was identified in a Streptococcus pyogenes strain of the clinically important M1 serotype. IS1562 is located in the mga regulon between the genes coding for the M protein and the C5a peptidase, both important virulence factors. The same or similar insertion sequences were found in most S. pyogenes strains, but the chromosomal location differed among isolates.
Berge
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Section for Molecular Pathogenesis, Department of Cell and Molecular Biology, Lund University, Lund, Sweden. Andreas.Berge@medkem.lu.se
Rasmussen
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Björck
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D018829:Adhesins, Bacterial; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D002874:Chromosome Mapping; D004251:DNA Transposable Elements; D010450:Endopeptidases / Q000235:genetics; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; C097739:SIC protein, Streptococcus; D010450:Endopeptidases; C053088:C5a peptidase