title: [A patient with Streptococcus intermedius brain abscess treated with high dose penicillin G--susceptibility of the isolate to penicillin G and the concentration of penicillin G in cerebrospinal fluid].
abstract: We report here a 2-year-old boy with a Streptococcus intermedius brain abscess and bilateral ventriculitis successfully treated with a high dose penicillin G (200,000 U/kg/dose, 6 times a day, 1 hour continuous infusion). Although hydrocephalus residuced, the high dose penicillin G therapy cured his brain abscess and bilateral ventriculitis. The minimal inhibitory concentration of penicillin G to the isolate was 0.008 microgram/ml. The penicillin G concentration in the cerebrospinal fluid after 2 hours from the infusion was about 5 micrograms/ml. S. intermedius must be considered as one of the causative agents for brain abscess. High dose penicillin G therapy is one choice of treatment for brain abscess due to penicillin-susceptible streptococci.
authors.affiliation: Department of Pediatrics, Asahikawa Medical College.
authors.forename: M
authors.initials: M
authors.lastname: Saijo
authors.forename: K
authors.initials: K
authors.lastname: Murono
authors.forename: Y
authors.initials: Y
authors.lastname: Hirano
authors.forename: K
authors.initials: K
authors.lastname: Fujita
mesh_terms: D001922:Brain Abscess / Q000188:drug therapy*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D010400:Penicillin G / Q000008:administration & dosage* / Q000134:cerebrospinal fluid; D010403:Penicillin Resistance; D010406:Penicillins / Q000008:administration & dosage* / Q000134:cerebrospinal fluid; D013290:Streptococcal Infections / Q000188:drug therapy*; D013291:Streptococcus / Q000187:drug effects*
chemical_list: D010406:Penicillins; D010400:Penicillin G