title: Adenovirus-associated gastro-enteritis in the north-west of England: 1991-1994.
abstract: Faeces, positive for adenoviruses by electron microscopy on initial examination at Manchester Public Health Laboratory (PHL) or Preston PHL during the period 1991-1994, were examined by an enzyme immunoassay which differentiated Ad40, Ad41 and non-AdF strains. Isolation and serotyping by neutralisation of non-AdF strains were attempted in PLC/PRF/5 cells. Of 452 specimens examined, 99 (22%) contained Ad40, 209 (46%) Ad41 and 144 (32%) non-AdF serotypes. From 1991 to 1993 the ratio of Ad40 to Ad41 was constant at approximately 1 to 1.6, but in 1994 it was almost 1 to 5. Non-AdF serotypes, of which Ad1 and Ad2 were the most common, accounted for 44% of specimens tested from 1991, but this dropped to 20% of those from 1994. An age/sex analysis showed that half the specimens examined were from infants under one year old, and that overall the male/female ratio was 3 to 2. The significance of these results is discussed, including the changing prevalence of Ad40 and Ad41, and the role of non-AdF serotypes in gastro-enteritis.
authors.affiliation: PHLS North West, Royal Preston Hospital, England, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Bryden
authors.forename: A
authors.initials: A
authors.lastname: Curry
authors.forename: H
authors.initials: H
authors.lastname: Cotterill
authors.forename: C
authors.initials: C
authors.lastname: Chesworth
authors.forename: I
authors.initials: I
authors.lastname: Sharp
authors.forename: S R
authors.initials: SR
authors.lastname: Wood
mesh_terms: D000258:Adenovirus Infections, Human / Q000453:epidemiology*; D000260:Adenoviruses, Human / Q000145:classification; D000293:Adolescent; D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence