title: Controlled trial of antituberculous chemotherapy in Crohn's disease: a five year follow up study.
abstract: BACKGROUND
  It has been suggested that Mycobacterium paratuberculosis is the cause of Crohn's disease. In a previous report the immediate effect of two years treatment with antituberculous chemotherapy showed no clinical benefit.
  
  
  OBJECTIVE
  To assess both the immediate and longer term effect of treatment on the disease.
  
  
  METHODS
  Patients were followed for five years from their date of entry to the study. One hundred and thirty patients entered the initial study, and of these 111 (81%) were followed regularly.
  
  
  RESULTS
  Overall, there was no evidence of consistent benefit or disadvantage from antituberculous chemotherapy in any of the assessments made, including the number of acute relapses, surgical episodes, hospital admissions, disease activity, blood tests, or medication required for Crohn's disease during the follow up period.
  
  
  CONCLUSIONS
  The absence of any benefit at the end of the initial two year trial period, and during the three year subsequent follow up, fails to support the hypothesis that mycobacteria play an important part in the pathogenesis of Crohn's disease, or that antituberculous chemotherapy may be of benefit.
authors.affiliation: Department of Gastroenterology, University Hospital of Wales, Heath Park, Cardiff, UK.
authors.forename: G A
authors.initials: GA
authors.lastname: Thomas
authors.forename: G L
authors.initials: GL
authors.lastname: Swift
authors.forename: J T
authors.initials: JT
authors.lastname: Green
authors.forename: R G
authors.initials: RG
authors.lastname: Newcombe
authors.forename: C
authors.initials: C
authors.lastname: Braniff-Mathews
authors.forename: J
authors.initials: J
authors.lastname: Rhodes
authors.forename: S
authors.initials: S
authors.lastname: Wilkinson
authors.forename: G
authors.initials: G
authors.lastname: Strohmeyer
authors.forename: G
authors.initials: G
authors.lastname: Kreuzpainter
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D003424:Crohn Disease / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D016927:Mycobacterium avium subsp. paratuberculosis; D017211:Treatment Failure
chemical_list: D000995:Antitubercular Agents