title: A cost-utility analysis of abdominal hysterectomy versus transcervical endometrial resection for the surgical treatment of menorrhagia.
abstract: Menorrhagia, or heavy regular menstrual bleeding, represents a major health burden to women. Trials comparing abdominal hysterectomy (AH) with transcervical resection of the endometrium (TCRE) for the condition have shown that, although the duration and severity of convalescence is less with TCRE, AH produces a permanent solution to heavy bleeding while TCRE fails in a proportion of women by 2 years. However, by 2 years, TCRE costs only 71% that of AH. This paper presents a cost-utility analysis to assess which procedure is more cost-effective overall. Under most plausible parameter values and on the basis of health state values elicited from a sample of women with menorrhagia, AH is likely to be considered more cost-effective than TCRE if purchasers are willing to pay an additional cost of at least 6,500 Pounds per extra quality-adjusted life-year generated by AH.
authors.affiliation: Brunel University.
authors.forename: M
authors.initials: M
authors.lastname: Sculpher
mesh_terms: D000328:Adult; D000465:Algorithms; D003362:Cost-Benefit Analysis; D004717:Endometrium / Q000601:surgery*; D005260:Female; D017048:Health Care Costs; D006801:Humans; D007044:Hysterectomy / Q000191:economics* / Q000379:methods; D008595:Menorrhagia / Q000191:economics* / Q000601:surgery*; D008875:Middle Aged; D019057:Quality-Adjusted Life Years; D011795:Surveys and Questionnaires; D013673:Technology Assessment, Biomedical; D016896:Treatment Outcome; D006113:United Kingdom