[The effect of hyperbaric oxygenation on liver energy metabolism in white rats with acute sodium nitrate poisoning].
The experimental study carried out on white rats, which was introduced of sodium nitrate at a dose of 9,6 g/kg of their mass. It is followed by the development of considerable disturbances of energy metabolism in liver. It has been shown the depression and the uncoupling of oxidation and phosphorylation, decrease of energy quotient in hepatic tissues. The results obtained permit supposing the significant role of nitric oxide (NO) in liver as a factor resulting in decrease of energy potential. The research has stated that the use of hyperbaric oxygenation (HBO) prevents difficult disturbances of energy metabolism in liver of white rats. The results permit supposing that the effect HBO is connected with the decrease of the speed of reduction of nitrate-ions to more toxic products of their biotransformation.
Hlebova
L Iu
LIu
Medical Stomatological Academy, Ministry of Public Health of the Ukraine, Poltava.
D000208:Acute Disease; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000493:pharmacokinetics; D004734:Energy Metabolism / Q000187:drug effects; D006931:Hyperbaric Oxygenation; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D009566:Nitrates / Q000493:pharmacokinetics / Q000506:poisoning*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011041:Poisoning / Q000378:metabolism / Q000628:therapy; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D002273:Carcinogens; D009566:Nitrates; C031618:sodium nitrate
Vplyv hiperbarychnoï oksyhenatsiï na enerhetychnyĭ metabolizm u pechintsi bilykh shchuriv pry hostriĭ intoksykatsiï nitratom natriiu.