title: Encapsulation of scleral buckling materials. A study of sixty specimens.
abstract: OBJECTIVE
  The purpose of the study was to obtain information on the encapsulation of two nonabsorbable biomaterials (silicone and hydrogel) used as explants in scleral buckling in retinal detachment surgery.
  
  
  METHODS
  The study design was a histopathologic study on a cohort of capsule fractions and complete eyes.
  
  
  METHODS
  Fifty-nine patients participated in this study, in which 60 specimens, including 37 hydrogel and 21 silicone capsule specimens as well as 2 whole eyes, were gathered. There were no control subjects.
  
  
  METHODS
  The capsule specimens were obtained from eyes operated on previously for scleral buckling for retinal detachment. The two whole eyes were enucleated. All specimens were studied with routine optic microscopy.
  
  
  METHODS
  Patient characteristics, type of scleral buckling, and number of operations performed were analyzed. Histologically, the capsular structure, its interface with the explant, and its different components also were studied. Remnants of the buckling material also were investigated.
  
  
  RESULTS
  There were 45 male and 14 female patients, with a mean age of 49 years. Histologically, capsule specimens had a fibrous matrix with fibroblasts and few inflammatory cells. Eighteen (48.6%) of 37 hydrogel capsule specimens displayed hydrogel fragments surrounded by a foreign body giant cell granuloma in 16 cases.
  
  
  CONCLUSIONS
  Nonabsorbable materials undergo encapsulation after implantation on the eye surface. Giant cell granuloma was observed in some hydrogel capsule specimens in relation to hydrogel fragmentation. The exact origin of this fragmentation remains unknown.
authors.affiliation: Department of Ophthalmology, Hôtel-Dieu, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: D'Hermies
authors.forename: J F
authors.initials: JF
authors.lastname: Korobelnik
authors.forename: G
authors.initials: G
authors.lastname: Caputo
authors.forename: B
authors.initials: B
authors.lastname: Mashhour
authors.forename: D
authors.initials: D
authors.lastname: Chauvaud
authors.forename: Y
authors.initials: Y
authors.lastname: Pouliquen
authors.forename: G
authors.initials: G
authors.lastname: Renard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000009:adverse effects; D002648:Child; D015353:Eye Enucleation; D005260:Female; D005355:Fibrosis; D015743:Giant Cells, Foreign-Body / Q000473:pathology*; D015745:Granuloma, Foreign-Body / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011102:Polyhydroxyethyl Methacrylate / Q000009:adverse effects; D012163:Retinal Detachment / Q000601:surgery; D012590:Sclera / Q000473:pathology; D012591:Scleral Buckling; D012826:Silicone Elastomers / Q000009:adverse effects
chemical_list: D001672:Biocompatible Materials; D012826:Silicone Elastomers; D011102:Polyhydroxyethyl Methacrylate