title: Vascular risks and incident dementia: results from a cohort study of the very old.
abstract: The contribution of vascular pathology to the manifestation of dementia and the importance of vascular risk to measures of cognitive function is being increasingly recognized. In particular, confirmation of this risk points towards approaches for prevention in large sections of the population. Information on determinants of incident dementia is increasing, but still relatively few studies of risk have been based on incident cases of dementia in very elderly populations. In this study based on incident cases of dementia in a population aged 75 and over, vascular risks were obtained from informants of the respondents with incident dementia. When compared with controls the factors associated with incident dementia were history of heart attack (odds ratio 2.9), transient ischaemic attacks (4.8), cerebrovascular accidents (3.4), family history of first-degree relatives with dementia (4.0), and occupational exposure to vibrating instruments (1.4). If only Alzheimer's disease, clinically diagnosed, was included, diabetes (1.4) and a history of dementia in first-degree relatives (6.6) emerged. Thus, vascular risk continues to be of importance in the oldest age groups.
authors.affiliation: Department of Community Medicine, University of Cambridge, Institute of Public Health, UK.
authors.forename: C
authors.initials: C
authors.lastname: Brayne
authors.forename: C
authors.initials: C
authors.lastname: Gill
authors.forename: F A
authors.initials: FA
authors.lastname: Huppert
authors.forename: C
authors.initials: C
authors.lastname: Barkley
authors.forename: E
authors.initials: E
authors.lastname: Gehlhaar
authors.forename: D M
authors.initials: DM
authors.lastname: Girling
authors.forename: D W
authors.initials: DW
authors.lastname: O'Connor
authors.forename: E S
authors.initials: ES
authors.lastname: Paykel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over / Q000502:physiology* / Q000523:psychology*; D000544:Alzheimer Disease / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D014652:Vascular Diseases / Q000150:complications*