title: Perinatal transmission of hepatitis C virus from human immunodeficiency virus type 1-infected mothers. Women and Infants Transmission Study.
abstract: Antepartum plasma hepatitis C virus (HCV) RNA was quantified in 155 mothers coinfected with HCV and human immunodeficiency virus type 1 (HIV-1), and HCV RNA was serially assessed in their infants. Of 155 singleton infants born to HCV antibody-positive mothers, 13 (8.4%) were HCV infected. The risk of HCV infection was 3.2-fold greater in HIV-1-infected infants compared with HIV-1-uninfected infants (17.1% of 41 vs. 5.4% of 112, P = .04). The median concentration of plasma HCV RNA was higher among the 13 mothers with HCV-infected infants (2.0 x 10(6) copies/mL) than among the 142 mothers with HCV-negative infants (3.5 x 10(5) copies/mL; P < .001), and there were no instances of HCV transmission from 40 mothers with HCV RNA concentrations of < 10(5) copies/mL. Women dually infected with HIV-1 and HCV but with little or no detectable HCV RNA should be reassured that the risk of perinatal transmission of HCV is exceedingly low.
authors.affiliation: Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Thomas
authors.forename: S A
authors.initials: SA
authors.lastname: Villano
authors.forename: K A
authors.initials: KA
authors.lastname: Riester
authors.forename: R
authors.initials: R
authors.lastname: Hershow
authors.forename: L M
authors.initials: LM
authors.lastname: Mofenson
authors.forename: S H
authors.initials: SH
authors.lastname: Landesman
authors.forename: F B
authors.initials: FB
authors.lastname: Hollinger
authors.forename: K
authors.initials: K
authors.lastname: Davenny
authors.forename: L
authors.initials: L
authors.lastname: Riley
authors.forename: C
authors.initials: C
authors.lastname: Diaz
authors.forename: H B
authors.initials: HB
authors.lastname: Tang
authors.forename: T C
authors.initials: TC
authors.lastname: Quinn
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D016174:Hepacivirus / Q000145:classification / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000150:complications / Q000276:immunology / Q000635:transmission* / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000821:virology; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D017423:Sequence Analysis, RNA
chemical_list: D012367:RNA, Viral