title: Herpes simplex encephalitis: a review.
abstract: Patients with herpes simplex encephalitis generally have altered mental function and are rarely able to provide a good medical history. Failure to diagnose this serious disease may result in permanent neurologic damage or death of the patient. Rapid institution of newer diagnostic tests such as polymerase chain reaction for herpes simplex virus is essential for proper diagnosis. Parenteral acyclovir therapy is efficacious but, clearly, improvements in prevention and therapy are still important research goals. This review is meant to inform physicians and nurses concerning the current diagnosis and management of this treatable but potentially fatal illness.
authors.affiliation: Division of Infectious Diseases, Hartford Hospital, Conn 06102-5037, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Levitz
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000188:drug therapy; D006561:Herpes Simplex / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D008487:Medical History Taking; D016133:Polymerase Chain Reaction
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir