title: [Diabetic neuropathy: thermal sensation and metabolic control in non-insulin-dependent diabetics].
abstract: BACKGROUND
  The early detection of peripheral neuropathy in diabetics is important since it is the main risk factor for lower limb trophic lesions in diabetics.
  
  
  OBJECTIVE
  To assess the relationship between feet thermal sensation threshold and metabolic control in ambulatory non-insulin-dependent diabetics.
  
  
  METHODS
  A random sample of 34 non-insulin-dependent diabetics followed for more than five years in a special clinic, out of 368 patients, was selected. Warmth sensation thresholds were measured in the dorsum of both feet using a MSTP-III thermostimulator. The average value of all glycosylated hemoglobins obtained during the 9.7 +/- 5.3 years of follow up for each patient was calculated. A multiple stepwise regression analysis was performed between thermal sensation as the dependent variable and glycosylated hemoglobin, fasting blood glucose, age and diabetes duration.
  
  
  RESULTS
  The regression model disclosed glycosylated hemoglobin as the only independent predictor of warmth sensation threshold (partial r = 0.385; p = 0.043). Fifteen diabetic patients with good metabolic control, defined as those with a mean glycosylated hemoglobin of less than 9.5%, had a warmth sensation threshold of 35.6 +/- 3.7 degrees C, whereas 19 diabetics with a had control (glycosylated hemoglobin > or = 9.5%) had a threshold of 39 +/- 3.8 degrees C (p = 0.017).
  
  
  CONCLUSIONS
  In this group of diabetics, there is a relationship between the severity of distal polyneuropathy and the metabolic control, assessed with glycosylated hemoglobin levels.
authors.affiliation: Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, P Universidad Católica de Chile, Santiago, Chile.
authors.forename: P
authors.initials: P
authors.lastname: Olmos
authors.forename: L
authors.initials: L
authors.lastname: Camilla
authors.forename: P
authors.initials: P
authors.lastname: Mellado
authors.forename: P
authors.initials: P
authors.lastname: Moya
authors.forename: P
authors.initials: P
authors.lastname: Arriagada
authors.forename: M
authors.initials: M
authors.lastname: Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Maiz
authors.forename: A
authors.initials: A
authors.lastname: Arteaga
authors.forename: N
authors.initials: N
authors.lastname: Velasco
authors.forename: A M
authors.initials: AM
authors.lastname: Acosta
authors.forename: M
authors.initials: M
authors.lastname: Escalona
authors.forename: M
authors.initials: M
authors.lastname: Borcoski
mesh_terms: D000368:Aged; D000553:Ambulatory Care; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000378:metabolism*; D017719:Diabetic Foot / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D005189:False Positive Reactions; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D012684:Sensory Thresholds; D013697:Thermosensing / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin
vernacular_title: Neuropatía diabética: sensibilidad térmica y control metabólico en diabéticos no insulinodependientes.