title: [Pestivirus as causative agent of abortion and perinatal mortality in cattle and sheep in Switzerland].
abstract: The causal involvement of bovine viral diarrhoea virus (BVDV) and border disease virus (BDV) infection in bovine and ovine abortion and perinatal mortality remain unclear. From 1992 until 1994, 213 bovine and 31 ovine foetuses as well as 36 calves and 25 lambs which had died perinatally were investigated. Tissue samples were tested for the presence of pestiviruses and serum or fluid from the body cavities were analysed for the presence of pestivirus antibodies. Detection of pestiviruses was performed by (i) cell culture isolation, (ii) antigen ELISA and (iii) immunohistochemical staining for viral antigen. For antibody-testing an indirect ELISA was used. In nine bovine foetuses and in two calves BVDV was isolated. Pestiviruses, most likely BDV were detected in one ovine foetus and three lambs. In 6% of the bovine and 11% of the ovine foetuses anti-pestivirus antibodies were detected. However, clinical features and history of bovine cases did not show a correlation with the diagnostic results, In contrast, the presence of central nervous system signs in neonatal lambs and the detection of BDV was correlated.
authors.affiliation: Institut für Veterinärpathologie, Universität Zürich.
authors.forename: B
authors.initials: B
authors.lastname: Thür
authors.forename: P
authors.initials: P
authors.lastname: Caplazi
authors.forename: M
authors.initials: M
authors.lastname: Hilbe
authors.forename: K
authors.initials: K
authors.lastname: Zlinszky
authors.forename: M
authors.initials: M
authors.lastname: Strasser
authors.forename: L
authors.initials: L
authors.lastname: Corboz
authors.forename: F
authors.initials: F
authors.lastname: Ehrensperger
mesh_terms: D000034:Abortion, Veterinary / Q000821:virology*; D000818:Animals; D001882:Border Disease / Q000453:epidemiology* / Q000401:mortality; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000453:epidemiology* / Q000401:mortality; D002417:Cattle; D002418:Cattle Diseases; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000662:veterinary*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D012756:Sheep; D012757:Sheep Diseases; D013557:Switzerland / Q000453:epidemiology
vernacular_title: Ursächliche Beteiligung von Pestiviren an Aborten und perinatalen Todesfällen bei Rindern und Schafen in der Schweiz.