title: Consensus workshop on the toxic effects of long-term PUVA therapy.
abstract: The possibility that there is an increased risk of melanoma in patients with psoriasis treated with psoralen-UV-A (PUVA) therapy has raised concern on the part of physicians and patients about the long-term safety of this treatment. In response to this concern, the National Psoriasis Foundation sponsored a workshop at which invited participants with expertise in PUVA therapy, psoriasis treatment, melanoma and nonmelanoma skin cancer, and epidemiological and clinical trials were asked to develop a consensus on the following 3 issues: the risk of long-term adverse effects of PUVA therapy with emphasis on nonmelanoma and melanoma skin cancer; the guidelines for physicians and patients for selection and use of PUVA therapy with consideration of the risk-benefit ratio of this treatment compared with the risk-benefit ratios of alternative treatments; and the directions for further evaluation of the long-term effects Of PUVA therapy.
authors.affiliation: Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Morison
authors.forename: R D
authors.initials: RD
authors.lastname: Baughman
authors.forename: R M
authors.initials: RM
authors.lastname: Day
authors.forename: P D
authors.initials: PD
authors.lastname: Forbes
authors.forename: H
authors.initials: H
authors.lastname: Hoenigsmann
authors.forename: G G
authors.initials: GG
authors.lastname: Krueger
authors.forename: M
authors.initials: M
authors.lastname: Lebwohl
authors.forename: R
authors.initials: R
authors.lastname: Lew
authors.forename: L
authors.initials: L
authors.lastname: Naldi
authors.forename: J A
authors.initials: JA
authors.lastname: Parrish
authors.forename: M
authors.initials: M
authors.lastname: Piepkorn
authors.forename: R S
authors.initials: RS
authors.lastname: Stern
authors.forename: G D
authors.initials: GD
authors.lastname: Weinstein
authors.forename: S E
authors.initials: SE
authors.lastname: Whitmore
mesh_terms: D006801:Humans; D008545:Melanoma / Q000139:chemically induced*; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy; D012306:Risk; D012878:Skin Neoplasms / Q000139:chemically induced*; D013997:Time Factors