Clinical and cytogenetic remission induced by interferon-alpha in a patient with chronic eosinophilic leukemia associated with a unique t(3;9;5) translocation.
A patient with chronic eosinophilic leukemia and a unique complex chromosomal translocation 46,XY,t(3;9;5)(q25;q34;q33) who had elevated blood interleukin-5 is reported. Complete cytogenetic remission was induced by interferon-alpha after treatment failure with corticosteroids and cytotoxic drugs. Severe cardiopulmonary symptoms due to hypereosinophilia and thromboembolic complication improved dramatically in the first 6 months of interferon therapy. Since it is known that the gene encoding for interleukin-5 resides on the long arm of chromosome 5, it may be possible that the chromosomal translocation in our patient resulted in overproduction of this cytokine, and our findings may be helpful for understanding the pathogenesis of this disorder.
Yamada
O
O
Department of Hematology, Tokyo Women's Medical College, Japan. GCB00062@niftyserve.or.jp
Kitahara
K
K
Imamura
K
K
Ozasa
H
H
Okada
M
M
Mizoguchi
H
H
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D002899:Chromosomes, Human, Pair 9; D002908:Chronic Disease; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000188:drug therapy* / Q000235:genetics; D016898:Interferon-alpha / Q000627:therapeutic use*; D007621:Karyotyping; D008297:Male; D012074:Remission Induction / Q000379:methods*; D019233:Retreatment; D014178:Translocation, Genetic
D000970:Antineoplastic Agents; D016898:Interferon-alpha