title: Immediate reaction to roxithromycin and prick test cross-sensitization to erythromycin and clarithromycin.
abstract: Allergic reactions to macrolides appear to be very rare. Only a few cases of fixed drug eruption or urticaria due to the administration of erythromycin have been reported. Cross-reaction between the different macrolides have not yet been published. We report a case of a 31-year-old female patient who developed generalized urticaria and tachycardia shortly after administration of roxithromycin (Rulid). Immediate-type hypersensitivity was confirmed by positive prick test reactions to roxithromycin and the chemically closely related macrolides erythromycin and clarithromycin.
authors.affiliation: Department of Dermatology, University of Cologne, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Kruppa
authors.forename: K
authors.initials: K
authors.lastname: Scharffetter-Kochanek
authors.forename: T
authors.initials: T
authors.lastname: Krieg
authors.forename: N
authors.initials: N
authors.lastname: Hunzelmann
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000737:chemistry; D017291:Clarithromycin / Q000009:adverse effects* / Q000737:chemistry; D003429:Cross Reactions; D004917:Erythromycin / Q000009:adverse effects* / Q000737:chemistry; D005260:Female; D006801:Humans; D007428:Intradermal Tests; D015575:Roxithromycin / Q000009:adverse effects* / Q000737:chemistry; D014581:Urticaria / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D015575:Roxithromycin; D004917:Erythromycin; D017291:Clarithromycin