[Signalling during radiation-induced apoptosis of thymocytes].
The mechanisms of signal triggering, enhancement and transduction during radiation-induced apoptosis of the thymocytes are discussed. Apoptosis is triggered by aggregation of receptors accompanied by activation of protein tyrosine kinases. The receptor aggregation is caused by radiation-induced cross-links. The signal is transduced to the gene from protein tyrosine kinase through Ras-proteins, protein kinase C, and transcription factors. The necessity of the lipoxygenase gene expression and synthesis of this enzyme for support and enhancement of the apoptotic signal is postulated.
Korystov
Iu N
IuN
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
Shaposhnikova
V V
VV
Egorova
M V
MV
D000818:Animals; D017209:Apoptosis / Q000502:physiology / Q000528:radiation effects*; D008214:Lymphocytes / Q000166:cytology / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects*; D015398:Signal Transduction / Q000528:radiation effects*; D013950:Thymus Gland / Q000166:cytology / Q000528:radiation effects*
Signalizatsiia pri radiatsionnom apoptoze timotsitov.