Spacing between the enhancer and promoter of the long terminal repeat of a murine leukaemia retrovirus is required for transcriptional activation in T cells.
In T cells, transcriptional activation by the long terminal repeat (LTR) of the mink cell focus-forming murine leukaemia virus requires some spacing between the enhancer and promoter. A large size-range of intervening sequences (11-93 bp) is able to activate transcription efficiently. Neither a specific nucleotide sequence nor stereospecific alignment of the spacer is important.
Chen
H
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MediGene GmbH, Martinsried, Germany.
Yoshimura
F K
FK
D016475:3T3 Cells; D000818:Animals; D004742:Enhancer Elements, Genetic; D006801:Humans; D019169:Jurkat Cells; D051379:Mice; D008908:Mink Cell Focus-Inducing Viruses / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D013601:T-Lymphocytes / Q000821:virology*; D015533:Transcriptional Activation