[Hemostasis in patients operated on for abdominal hemorrhage. 2. Characterization of the process of activation of blood coagulation system factors. Coagulation inhibitors].
Haemostasis indexes were estimated in four groups of patients which were isolated by the cluster analysis and operated for abdominal haemorrhages. A tendency or explicit hyperfibrinogenemia have been fixed which are connected with the syndrome of the system inflammation response of the patient in the critical state. The correlation between the indexes of the prothrombin time, activated partial prothrombin time and protein C activity is shown. An analysis of anticoagulants effect suggests it possible to consider the antithrombin III to be the main, stable blood anticoagulant, while protein C is responsible for the operational response of the organism on the part of haemostasis. The decrease of ancystron and thrombin time was recorded in 50% of patients notwithstanding the hyperfibrinogenemia and presence of fibrin fibrinogen degradation products. It is supposed that the acceleration of fibrin polymerization in the examined groups of patients is the mechanism of the organism protection from the blood loss under the given pathology.
Beliaev
A V
AV
Ukrainian State Medical University, Kyiv.
Zaremba
A M
AM
Platonova
T N
TN
Aristov
M A
MA
Rakov
N V
NV
D000005:Abdomen / Q000098:blood supply*; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors / Q000502:physiology*; D016000:Cluster Analysis; D005340:Fibrinogen / Q000378:metabolism; D006470:Hemorrhage / Q000601:surgery*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D010314:Partial Thromboplastin Time; D011486:Protein C / Q000378:metabolism; D011517:Prothrombin Time
D001779:Blood Coagulation Factors; D011486:Protein C; D005340:Fibrinogen
Gemostaz u bol'nykh, operirovannykh po povodu abdominal'nykh krovotecheniĭ. 2. Kharakteristika protsessa aktivatsii faktorov sistemy svertyvaniia krovi. Ingibitory svertyvaniia.