Clonal T-cell proliferation causing pure red cell aplasia in chronic B-cell lymphocytic leukaemia: successful treatment with cyclosporine following in vitro abrogation of erythroid colony-suppressing activity.
Clonal T cells that cause pure red cell aplasia were demonstrated in a patient with chronic B-cell lymphocytic leukaemia. The T-cell fraction was enriched by the immunomagnetic method and shown to have T-cell receptor-beta gene rearrangement. Cryopreserved T cells, obtained during the period of anaemia, suppressed autologous erythroid progenitor cell growth from remission marrow. The colony-suppressing activity was markedly improved by the addition of cyclosporine to the culture medium. The patient achieved haematological remission by cyclosporine monotherapy. Cyclosporine treatment may improve erythropoiesis in both a T-cell-dependent and a T-cell-independent manner.
Yamada
O
O
Department of Haematology, Tokyo Women's Medical College, Japan.
Yun-Hua
W
W
Motoji
T
T
Mizoguchi
H
H
D015139:Blotting, Southern; D002455:Cell Division; D016572:Cyclosporine / Q000627:therapeutic use*; D015672:Erythroid Precursor Cells / Q000473:pathology*; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D013601:T-Lymphocytes / Q000473:pathology*
D007166:Immunosuppressive Agents; D016572:Cyclosporine