Molecular fingerprinting of multidrug-resistant Salmonella enterica serotype Typhi.
For epidemiologic investigations, the primary subdivision of Salmonella Typhi is vi-phage typing; 106 Vi-phage types are defined. For multidrug-resistant strains the most common types have been M1 (Pakistan) and E1 (India, Pakistan, Bangladesh, and the Arabian Gulf); a strain untypable with the Vi phages has been responsible for a major epidemic in Tajikistan. Most often, isolates from the Indian subcontinent have been resistant to ampicillin, chloramphenicol, streptomycin, sulfonamides, tetracyclines, and trimethoprim; but in the 1997 Tajikistan outbreak, the epidemic strain was also resistant to ciprofloxacin. For multidrug-resistant strains, subdivision within phage type can be achieved by plasmid profile typing and pulsed-field gel electrophoresis.
Hampton
M D
MD
Central Public Health Laboratory, London, United Kingdom.
Ward
L R
LR
Rowe
B
B
Threlfall
E J
EJ
D001208:Asia; D001434:Bacteriophage Typing; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D010802:Phylogeny; D010957:Plasmids / Q000235:genetics; D012485:Salmonella typhi / Q000145:classification* / Q000187:drug effects / Q000235:genetics*; D012703:Serotyping
D004269:DNA, Bacterial