Models for the length distributions of actin filaments: II. Polymerization and fragmentation by gelsolin acting together.
In a previous paper, we studied elementary models for polymerization, depolymerization, and fragmentation of actin filaments (Edelstein-Keshet and Ermentrout, 1988, Bull. Math. Biol. 60, 449-475). When these processes act together, more complicated dynamics occur. We concentrate on a particular case study, using the actin-fragmenting protein gelsolin. A set of biological parameter values (drawn from the experimental literature) is used in computer simulations of the kinetics of gelsolin-mediated actin filament fragmentation.
Ermentrout
G B
GB
Department of Mathematics, University of Pittsburgh, PA 15260, USA.
Edelstein-Keshet
L
L
D000199:Actins / Q000737:chemistry / Q000378:metabolism*; D001704:Biopolymers / Q000737:chemistry / Q000378:metabolism; D003198:Computer Simulation; D018260:Gelsolin / Q000378:metabolism; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological
D000199:Actins; D001704:Biopolymers; D018260:Gelsolin