Site-specific integration of adeno-associated virus into an episome with the target locus via a deletion-substitution mechanism.
Five site-specific adeno-associated virus integrants generated in a model system with an Epstein-Barr virus- based shuttle vector have been characterized. The results suggest a deletion-substitution mechanism of recombination.
Dyall
J
J
Department of Microbiology, W. R. Hearst Microbiology Research Center, Cornell University Medical College, New York, New York 10021, USA.
Berns
K I
KI
D000229:Dependovirus / Q000235:genetics*; D010957:Plasmids; D011995:Recombination, Genetic; D016662:Virus Integration