title: Pyodermia chronica glutealis complicated by acromegalic gigantism.
abstract: We report a case of pyodermia chronica glutealis complicated by acromegalic gigantism associated with hyperprolactinemia. The serum prolactin, growth hormone, adrenocorticotropic hormone, and 11-deoxycortisol levels were elevated, but the estradiol and dehydroepiandrosterone-sulphate levels were within normal limits. However, the testosterone level was very low. Histopathologically, we found sinus tracts and scarring in a specimen from the buttocks. We could not immunohistochemically detect clear androgen, growth hormone, or prolactin receptors at any site. The patient was a man with a height of 197 cm and weight of 140 kg, he had clinical features of active acromegaly such as excessive sweating and increased thickness of soft tissue. He was also diagnosed with diabetes mellitus. Under such conditions, bacteria could easily grow and lesions might have been aggravated by the heavy pressure from his weight, a possible causes of his pyodermia chronica glutealis.
authors.affiliation: Division of Dermatology, Kansai Medical University, Kori Hospital, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nishijima
authors.forename: M
authors.initials: M
authors.lastname: Kasahara
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Kondoh
authors.forename: A
authors.initials: A
authors.lastname: Tsubura
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000175:diagnosis; D000328:Adult; D002081:Buttocks; D002908:Chronic Disease; D005500:Follow-Up Studies; D005877:Gigantism / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications* / Q000175:diagnosis; D008297:Male; D011711:Pyoderma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016038:Skin Transplantation