[The development of a method for viral inactivation using thiophosphamide].
Using three-functional alkylating compound thiophosphamide complete inactivation of the influenza and herpesviruses of type 1 and 2 was achieved. The method provides full inactivation of DNA- and RNA-containing viruses and preservation of their immunogenic properties.
Shved
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AD
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv.
Kitam
O E
OE
Skrypchenko
H S
HS
Tokolova
S S
SS
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002642:Chick Embryo; D003864:Depression, Chemical; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000276:immunology; D009980:Influenza A virus / Q000187:drug effects* / Q000276:immunology; D007252:Influenza Vaccines; D013852:Thiotepa / Q000494:pharmacology*; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D014776:Virus Cultivation
D000477:Alkylating Agents; D000998:Antiviral Agents; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D013852:Thiotepa
Rozrobka sposobu inaktyvatsiï virusiv za dopomohoiu tiofosfamidu.