title: [Blood-brain barrier evaluation in bone marrow transplantation].
abstract: The blood-brain barrier (BBB) contributes to the central nervous system (CNS) immunological isolation. BBB has never been studied in patients who developed chronic graft-versus-host disease (GVHD) after allogeneic bone marrow transplants (BMT), from HLA identical related donors. BBB disruption was investigated through the cerebrospinal fluid (CSF) proteins, quantitative and graphically, in order to detect the incidence and possible pathophysiology of the CNS involvement in chronic GVHD. Thirty three CSF and matched serum samples from chronic myeloid leukemia patients were collected pre BMT pos BMT and during chronic GVHD. There was no evidence of BBB disruption in any patient studied.
authors.affiliation: Serviço de TMO, Hospital de Clínicas, Universidade Federal do Paraná (HC-UFPR), Curitiba, Brasil.
authors.forename: S M
authors.initials: SM
authors.lastname: de Almeida
authors.forename: J A
authors.initials: JA
authors.lastname: Livramento
authors.forename: R
authors.initials: R
authors.lastname: Passqüini
authors.forename: V B
authors.initials: VB
authors.lastname: Palou
authors.forename: A M
authors.initials: AM
authors.lastname: de Oliveira
authors.forename: E M
authors.initials: EM
authors.lastname: Doi
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: M C
authors.initials: MC
authors.lastname: Aso
authors.forename: E
authors.initials: E
authors.lastname: Ferreira
mesh_terms: D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D016026:Bone Marrow Transplantation; D002490:Central Nervous System / Q000503:physiopathology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000418:Albumins; D002556:Cerebrospinal Fluid Proteins
vernacular_title: Avaliação da barreira hemato-encepfálica no transplante de medula óssea.