title: Dendritic alterations in cortical pyramidal cells in the sparse fur mouse.
abstract: Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in sparse fur (spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both the complexity of the dendritic arbor and in dendritic terminal spine density (60%) in spf/Y mice compared with controls. Such reductions may contribute to behavioral dysfunction observed in spf/Y mice.
authors.affiliation: Department of Environmental Toxicology, University of California, Riverside, CA 92521, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Hopkins
authors.forename: J
authors.initials: J
authors.lastname: McKean
authors.forename: R F
authors.initials: RF
authors.lastname: Mervis
authors.forename: M L
authors.initials: ML
authors.lastname: Oster-Granite
mesh_terms: D000818:Animals; D048429:Cell Size; D002540:Cerebral Cortex / Q000201:enzymology / Q000473:pathology*; D003712:Dendrites / Q000473:pathology*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009954:Ornithine Carbamoyltransferase / Q000235:genetics*; D017966:Pyramidal Cells / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D009954:Ornithine Carbamoyltransferase