title: Microphthalmia (mi) mice display an aberrant bone trace element composition.
abstract: It has been recognized that bone trace element composition analysis provides clues when analyzing bone-related physiological conditions. Increasing numbers of bone-related genetic diseases have been identified recently. In this study, we have analyzed bone trace element composition in a genetic mutant animal model. Mutations in the mouse microphthalmia (mi) gene affect the development of a number of cell types, including melanocytes, mast cells, and osteoclasts. Previous studies have shown that different alleles of the mi locus show osteopetrosis. In order to gain insights into the effects of a particular genetic defect on bone trace element composition and bone structure, we performed bone trace element composition analysis using inductively coupled plasma atomic emissions spectrometry (ICP-AES). Marked changes in bone trace element levels were found in vertebrate bones of mi mutant mice. The implications and possible applications of bone trace element analysis will be discussed in this article.
authors.affiliation: Cellular and Developmental Biology Division, Kurume University Research Center for Innovative Cancer Therapy, Fukuoka, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: R
authors.initials: R
authors.lastname: Haraguchi
authors.forename: K
authors.initials: K
authors.lastname: Terai
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: Y
authors.initials: Y
authors.lastname: Kitamura
authors.forename: T
authors.initials: T
authors.lastname: Minami
authors.forename: M O
authors.initials: MO
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Izumi
authors.forename: R
authors.initials: R
authors.lastname: Nagata
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D008850:Microphthalmos / Q000235:genetics / Q000378:metabolism*; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000378:metabolism*
chemical_list: D014131:Trace Elements