Temporal relationship modeling: DTP or DT immunizations and infantile spasms.
The time relationship between DTP immunization and infantile spasms (IS) onset was examined using three models--association, temporal shift, and no-effect--and the case/control data from the National Childhood Encephalopathy Study (NCES). Infantile spasms cases classified as being previously abnormal (e.g., tuberous sclerosis complex patients) showed a no-effect relationship, whereas those classified as previously normal suggested a fit to the temporal shift model, i.e. no increase in number of cases but a shortening of time to onset of seizure. No data fit the association model. Analyses for vaccine complications should examine for temporal changes (i.e. temporal shift) in addition to increased risks.
Goodman
M
M
Johns Hopkins University School of Public Health, Washington, DC 20007, USA.
Lamm
S H
SH
Bellman
M H
MH
D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000009:adverse effects*; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007114:Immunization; D007223:Infant; D008297:Male; D013036:Spasms, Infantile / Q000453:epidemiology / Q000209:etiology*; D013745:Tetanus Toxoid / Q000009:adverse effects*; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology; D017778:Vaccines, Combined / Q000009:adverse effects
D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D013745:Tetanus Toxoid; D017778:Vaccines, Combined