title: [Intrathecal immunoglobulin synthesis evaluation in bone marrow transplantation].
abstract: The central nervous system involvement in chronic graft versus host disease (GVHD) has been suggested. Chronic GVHD resembles auto immune connective tissue disorders. In order to investigate the immunoglobulin intra blood brain barrier (BBB) synthesis during chronic GVHD, and contribute to understanding the pathophysiology of the disease, we studied 33 patients who underwent allogeneic bone marrow transplants (BMT) from HLA identical related donors. Immunoglobulin intra BBB synthesis was investigated quantitative and qualitatively. The samples were collected pre BMT, pos BMT and during chronic GVHD. There were no evidence of immunoglobulin intra BBB synthesis, and no oligoclonal bands were found. Only isolated cases suggested IgO and IgA intra BBB synthesis, and in one case IgM during GVHD.
authors.affiliation: Serviço de TMO, Hospital de Clínicas, Universidade Federal do Paraná (HC-UFPR), Curitiba, Brasil.
authors.forename: S M
authors.initials: SM
authors.lastname: de Almeida
authors.forename: J A
authors.initials: JA
authors.lastname: Livramento
authors.forename: R
authors.initials: R
authors.lastname: Pasquini
authors.forename: V B
authors.initials: VB
authors.lastname: Palou
authors.forename: A M
authors.initials: AM
authors.lastname: de Oliveira
authors.forename: E M
authors.initials: EM
authors.lastname: Doi
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: M C
authors.initials: MC
authors.lastname: Aso
authors.forename: E
authors.initials: E
authors.lastname: Ferreira
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000134:cerebrospinal fluid* / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged
chemical_list: D007136:Immunoglobulins
vernacular_title: Avaliação da síntese intratecal de immunoglobulinas no transplante de medula óssea.