Metabolic changes of acetaminophen after intravenous administration to rats pretreated with 2-(allylthio)pyrazine.
Kwak
M K
MK
College of Pharmacy, Seoul National University, Republic of Korea.
Lee
W I
WI
Kim
N D
ND
Lee
M G
MG
D000082:Acetaminophen / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D018712:Analgesics, Non-Narcotic / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008658:Inactivation, Metabolic; D008297:Male; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
C104935:2-(allylthio)pyrazine; D018712:Analgesics, Non-Narcotic; D004791:Enzyme Inhibitors; D011719:Pyrazines; D000082:Acetaminophen; C037386:acetaminophen glucuronide; D003577:Cytochrome P-450 Enzyme System; C045667:acetaminophen sulfate ester