Role of bradykinin in the reduction of left ventricular hypertrophy induced by angiotensin-converting enzyme inhibitors in spontaneously hypertensive rats.
We examined the effects of icatibant, a specific bradykinin B2-receptor antagonist, on the regression of left ventricular mass (LVM) induced by angiotensin converting enzyme (ACE) inhibitors, ramipril and imidapril, in spontaneously hypertensive rats. Both ramipril and imidapril lowered blood pressure equally, which were not influenced by icatibant. Icatibant did not alter the regressive effect of imidapril, while it showed a tendency to increase LVM in the ramipril-treated rats. The changes of LVM induced by icatibant were significantly different between the ramipril- and the imidapril-treated rats, suggesting that the role of bradykinin in the antihypertrophic effect might differ among ACE inhibitors.
Sugimoto
K
K
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Fujimura
A
A
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000502:physiology* / Q000627:therapeutic use; D065168:Bradykinin Receptor Antagonists; D017379:Hypertrophy, Left Ventricular / Q000139:chemically induced / Q000188:drug therapy*; D007093:Imidazoles / Q000009:adverse effects*; D048289:Imidazolidines; D017257:Ramipril / Q000009:adverse effects*; D051381:Rats; D011918:Rats, Inbred SHR
D000806:Angiotensin-Converting Enzyme Inhibitors; D065168:Bradykinin Receptor Antagonists; D007093:Imidazoles; D048289:Imidazolidines; C065679:icatibant; C065166:imidapril; D017257:Ramipril; D001920:Bradykinin