Association of primary antiphospholipid syndrome with inherited activated protein C resistance.
A 65-year-old man had had arterial thromboses of the lower limbs and cerebral region for several years; tests revealed anticardiolipin, antiphosphatidylserine, anti-beta2-glycoprotein I antibodies, and lupus anticoagulant. As well, both phenotypic and genotypic resistance to activated protein C was found. Antiphospholipid antibodies have been reported to interfere in different ways with the functions of protein C; in our patient the simultaneous existence of inherited resistance to activated protein C could account for the thrombophilic status underlying the diffuse and serious arterial thromboses.
Picillo
U
U
Institute of Clinical Medicine, Rheumatology Unit, Faculty of Medicine, 2nd University of Naples, Napoli, Italy.
De Lucia
D
D
Palatiello
E
E
Scuotto
A
A
Marcialis
M R
MR
Pezzella
S
S
Tirri
G
G
D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications* / Q000473:pathology; D005165:Factor V / Q000235:genetics*; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D009154:Mutation; D011486:Protein C / Q000235:genetics*; D013923:Thromboembolism / Q000150:complications* / Q000235:genetics / Q000473:pathology; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics / Q000473:pathology; D053482:beta 2-Glycoprotein I
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D006023:Glycoproteins; D016682:Lupus Coagulation Inhibitor; D011486:Protein C; D053482:beta 2-Glycoprotein I; C095381:factor V Leiden; D005165:Factor V