Goserelin acetate (Zoladex) with or without hormone replacement therapy for the treatment of endometriosis.
OBJECTIVE
To determine whether hormone replacement therapy (HRT) plus goserelin (Zoladex) is as effective as goserelin alone for the relief of pelvic symptoms of endometriosis and to determine whether it reduces both the loss of bone mineral density (BMD) and the physiologic side effects associated with goserelin therapy.


METHODS
Prospective, placebo-controlled study, open label for goserelin therapy and double-blind for HRT.


METHODS
Forty-two teaching or community hospitals.


METHODS
Premenopausal women with symptomatic endometriosis.


RESULTS
Statistically significant mean decreases from baseline in the total pelvic symptom score and total subjective score were observed by week 24 for all three groups. There were no statistically significant treatment differences for change in total symptom score. Some degree of BMD loss occurred in the three groups; however, the percentage loss was consistently greater in the HRT0 group than in the HRT1 or HRT2 groups. When analyzed separately, no overall age effect on BMD change was seen in women >30 years of age versus women < or = 30 years. The HRT1 and HRT2 groups had fewer occurrences of hot flushes and vaginal dryness than did the HRT0 group.


CONCLUSIONS
Goserelin plus HRT is as effective as goserelin alone in relieving pelvic symptoms of endometriosis and attenuates both the loss of BMD and the physiologic side effects of hot flushes and vaginal dryness associated with goserelin therapy.
Moghissi
K S
KS
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA.
Schlaff
W D
WD
Olive
D L
DL
Skinner
M A
MA
Yin
H
H
D000293:Adolescent; D000328:Adult; D015519:Bone Density / Q000187:drug effects; D004311:Double-Blind Method; D004715:Endometriosis / Q000503:physiopathology / Q000628:therapy*; D015914:Estrogen Replacement Therapy; D005260:Female; D017273:Goserelin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology; D008875:Middle Aged; D010388:Pelvis / Q000503:physiopathology; D011446:Prospective Studies
D017273:Goserelin