A stochastic model of cellular transformation and its relevance to chemical carcinogenesis.
A mathematical model is presented which determines the relationship of cellular mutation to cellular survival and transformation. The basis for this model is the hypothesis that the entropy associated with changes of genotype are linearly proportional to the entropy associated with changes in phenotype. This hypothesis leads to a mathematical derivation relating cellular survival, mutation and transformation. The relevance of this model to data derived from experiments in chemical carcinogenesis is presented.
Alfano
F D
FD
Waterbury Hospital Health Center, Department of Medicine, CT 06721, USA. falfano@erols.com
D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000235:genetics; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009154:Mutation; D013269:Stochastic Processes
D002273:Carcinogens