Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury.
Neurotoxic injury of the caudate-putamen and lateral globus pallidus unilaterally initiated transneuronal degeneration of neurons in the ipsilateral substantia nigra reticulata (SNR). Quantification of SNR neurons using unbiased stereology demonstrated that neuron loss began 4 days after the initial striatal lesion, followed by significant loss (50%) at 6 days and a plateau at 8 days. Analysis at the light and ultrastructural levels revealed morphological changes consistent with a type of programmed cell death. These temporal and histological results refine an in vivo model in which to explore mechanisms of delayed neuronal degeneration.
DeGiorgio
L A
LA
Department of Neurology and Neuroscience, Cornell University Medical School, The Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.
Dibinis
C
C
Milner
T A
TA
Saji
M
M
Volpe
B T
BT
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002452:Cell Count; D003342:Corpus Striatum / Q000473:pathology*; D018690:Excitatory Amino Acid Agonists; D007051:Ibotenic Acid; D008297:Male; D008854:Microscopy, Electron; D009410:Nerve Degeneration / Q000139:chemically induced / Q000473:pathology*; D009474:Neurons / Q000166:cytology / Q000648:ultrastructure; D009498:Neurotoxins; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000473:pathology*
D018690:Excitatory Amino Acid Agonists; D009498:Neurotoxins; D007051:Ibotenic Acid