Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with Lewy body parkinsonism.
Genetic analysis of markers from chromosomes 4q21-23 and 17q21 in a family with apparently autosomal dominant Lewy body parkinsonism is presented. This analysis shows that the locus leading to this disease is not allelic with that previously shown to lead to Lewy body parkinsonism on chromosome 4 or to the locus on chromosome 17 leading to frontotemporal dementia with parkinsonism. A brief clinical comparison of this family with families showing linkage to these loci is presented. The data suggest that at least one other major genetic determinant for Lewy body parkinsonism remains to be identified.
Hardy
J
J
Mayo Clinic Jacksonville, Florida 32224, USA. hardy@mayo.edu
Pérez-Tur
J
J
Baker
M
M
Farrer
M
M
Crook
R
R
Hutton
M
M
Johnson
W G
WG
Gwinn
K
K
Muenter
M
M
Rocca
W A
WA
Maraganore
D
D
D000328:Adult; D000483:Alleles; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D016631:Lewy Bodies; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000145:classification / Q000235:genetics* / Q000473:pathology; D010375:Pedigree
D005819:Genetic Markers