title: Using mitochondrial and nuclear DNA markers to reconstruct human evolution.
abstract: Molecular genetic-data have greatly improved our ability to test hypotheses about human evolution. During the past decade, a large amount of nuclear and mitochondrial data have been collected from diverse human populations. Taken together, these data indicate that modern humans are a relatively young species. African populations show the largest amount of genetic diversity, and they are the most genetically divergent population. Modern human populations expanded in size first on the African continent. These findings support a recent African origin of modern humans, but this conclusion should be tempered by the possible effects of factors such as gene flow, population size differences, and natural selection.
authors.affiliation: Department of Human Genetics, University of Utah, Salt Lake City 84112, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Jorde
authors.forename: M
authors.initials: M
authors.lastname: Bamshad
authors.forename: A R
authors.initials: AR
authors.lastname: Rogers
mesh_terms: D000349:Africa; D001208:Asia; D005075:Biological Evolution; D004247:DNA / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005060:Europe; D018703:Founder Effect; D014644:Genetic Variation / Q000235:genetics; D005828:Genetics, Population; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D008957:Models, Genetic
chemical_list: D004272:DNA, Mitochondrial; D004247:DNA