title: [Asthma associated with gastroesophageal reflux].
abstract: OBJECTIVE
  In order to explore the association between poorly controllable asthma and gastroesophageal reflux (GER), a prospective clinical trial is presented.
  
  
  METHODS
  This trial included 28 patients with negative atopic indicators who presented difficulty in the management of their disease. All patients underwent a complete medical history as well as skin tests for common airborne allergens, total serum IgE, peripheral blood eosinophils, spirometry, chest X-ray and esophageal barium films. Additionally, esophageal endoscopy was performed on 9 patients, and esophageal manometry in 1 patient. All were submitted to antireflux therapy and received omeprazole and cisapride for 8 weeks.
  
  
  RESULTS
  Complete improvement was observed in 24 patients (85.7%), moderate improvement in 3 patients (10.7%), and no improvement in 1 patient (3.6%). Three patients required antireflux surgery.
  
  
  CONCLUSIONS
  Symptoms reappeared 2-3 weeks after suspending treatment, which led to the recommendation that antireflux measures become a way of life for these patients.
authors.affiliation: Clínica de Asma del servicio de neumología, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, NL, México.
authors.forename: J E
authors.initials: JE
authors.lastname: González Morales
authors.forename: L
authors.initials: L
authors.lastname: Leal de Hernández
authors.forename: D
authors.initials: D
authors.lastname: González Spencer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000209:etiology* / Q000517:prevention & control; D020117:Cisapride; D003131:Combined Modality Therapy; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D004945:Esophagoscopy; D005260:Female; D005541:Forced Expiratory Volume; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006551:Hernia, Hiatal / Q000150:complications / Q000601:surgery; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D011446:Prospective Studies; D012074:Remission Induction; D012882:Skin Tests; D016896:Treatment Outcome
chemical_list: D004791:Enzyme Inhibitors; D005765:Gastrointestinal Agents; D010880:Piperidines; D007073:Immunoglobulin E; D009853:Omeprazole; D020117:Cisapride
vernacular_title: Asma asociada a reflujo gastroesofágico.