title: Erythema nodosum: a presenting sign of early onset sarcoidosis.
abstract: "Early onset sarcoidosis" is a chronic granulomatous disease occurring in children younger than 5 years of age, and characterized by a classic symptom triad consisting of skin, eye and joint lesions, with on rare occasion pulmonary involvement. The disorder often goes unrecognized because of its rarity and, since polyarthritis and uveitis are the predominant symptoms, most of these children are misdiagnosed as having juvenile chronic arthritis (JCA). A child with erythema nodosum at 7 months of age, later diagnosed as JCA and definitively recognized as "early onset sarcoidosis" is reported. This case shows that, whenever possible, a biopsy showing the typical picture of sarcoid granulomas is crucial to distinguish these clinical conditions.
authors.affiliation: Centro di Immunologia-Infettivologia, Università di Roma Tor Vergata, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Cancrini
authors.forename: F
authors.initials: F
authors.lastname: Angelini
authors.forename: M
authors.initials: M
authors.lastname: Colavita
authors.forename: E
authors.initials: E
authors.lastname: Cortis
authors.forename: L
authors.initials: L
authors.lastname: Chini
authors.forename: F
authors.initials: F
authors.lastname: Mammone
authors.forename: P
authors.initials: P
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: De Sanctis
mesh_terms: D017668:Age of Onset; D001171:Arthritis, Juvenile / Q000175:diagnosis*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004893:Erythema Nodosum / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007223:Infant; D012507:Sarcoidosis / Q000175:diagnosis*