title: Usefulness of laparoscopy with liver biopsy in the assessment of liver involvement at diagnosis of Hodgkin's and non-Hodgkin's lymphomas.
abstract: BACKGROUND
  Staging of lymphoma at diagnosis determines therapeutic strategy and disease prognosis. Hepatic involvement, demonstrated by laparotomy or laparoscopy, is frequent in Hodgkin's and non-Hodgkin's lymphoma. However, it is unclear whether these procedures are still necessary or whether they should be replaced by less invasive techniques.
  
  
  METHODS
  Laparoscopy-assisted liver biopsies, as well as laboratory studies, bone marrow biopsy, and thoracic and abdominal computed tomography, were performed as an initial staging evaluation in 112 consecutive patients who were diagnosed with Hodgkin's or non-Hodgkin's lymphoma.
  
  
  RESULTS
  Hepatic lymphomatous involvement was demonstrated in 18 patients (16%). It was more frequent in non-Hodgkin's (24%) than in Hodgkin's (8%) lymphomas (p < 0.04) and among stage III and IV (24%) than stage I and 11 (10%) patients (p < 0.05). The laparoscopic finding of white spots or nodules on the liver surface had a 100% specificity in the diagnosis of lymphomatous liver involvement. Conversely, hepatomegaly on both laparoscopy and computed tomography, as well as laboratory studies, had a low sensitivity and specificity.
  
  
  CONCLUSIONS
  Laparoscopy-assisted liver biopsy was a useful technique to establish hepatic lymphomatous involvement, which was not identified by either computed tomography or laboratory studies.
authors.affiliation: Liver Unit and Hematology Department Hospital Clínic i Provincial, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Sans
authors.forename: V
authors.initials: V
authors.lastname: Andreu
authors.forename: J M
authors.initials: JM
authors.lastname: Bordas
authors.forename: J
authors.initials: J
authors.lastname: Llach
authors.forename: A
authors.initials: A
authors.lastname: López-Guillermo
authors.forename: F
authors.initials: F
authors.lastname: Cervantes
authors.forename: M
authors.initials: M
authors.lastname: Bruguera
authors.forename: F
authors.initials: F
authors.lastname: Mondelo
authors.forename: E
authors.initials: E
authors.lastname: Montserrat
authors.forename: J
authors.initials: J
authors.lastname: Terés
authors.forename: J
authors.initials: J
authors.lastname: Rodés
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D010535:Laparoscopy / Q000379:methods*; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000175:diagnosis*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed; D000637:Transaminases / Q000378:metabolism
chemical_list: D007770:L-Lactate Dehydrogenase; D000637:Transaminases