title: Regional cerebral blood volume after severe head injury in patients with regional cerebral ischemia.
abstract: OBJECTIVE
  Recent early cerebral blood flow (CBF) studies in cases of severe head injury have revealed ischemia in a substantial number of patients with a variety of computed tomographically demonstrated diagnoses. The underlying derangements causing this early ischemia are unknown, but cerebral blood volume (CBV) measurements might offer some insight into this pathological abnormality.
  
  
  METHODS
  For this purpose, stable xenon-enhanced computed tomography was used for assessment of CBF, and a dynamic computed tomographic imaging technique was used for determining CBV. Based on the occurrence of regional ischemia (CBF < 20 ml/100 g/min), seven patients with varying anatomic lesions revealed by computed tomography were identified for comparison between CBF and CBV in ischemic and nonischemic areas.
  
  
  RESULTS
  Both CBF (15+/-4.3 versus 34+/-11 g/min, P < 0.002) and CBV (2.5+/-1.0 versus 4.9+/-1.9 ml/100 g) exhibited significantly lower values in the ischemic zones than in the nonischemic zones (means+/-standard deviations). Among 26 patients with or without ischemia observed during their initial follow-up studies, which were conducted between Days 2 and 8, all patients showed CBF and CBV values within the low-normal range.
  
  
  CONCLUSIONS
  These data evidently support the suggestion that compromise of the microvasculature is the cause of early ischemia, rather than vasospasm of the larger conductance vessels.
authors.affiliation: Department of Neurological Surgery, University of California, Davis, Sacramento 95817, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Schröder
authors.forename: J P
authors.initials: JP
authors.lastname: Muizelaar
authors.forename: P P
authors.initials: PP
authors.lastname: Fatouros
authors.forename: A J
authors.initials: AJ
authors.lastname: Kuta
authors.forename: S C
authors.initials: SC
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D001810:Blood Volume / Q000502:physiology*; D002545:Brain Ischemia / Q000209:etiology* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D006259:Craniocerebral Trauma / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014057:Tomography, X-Ray Computed