Pulmonary adenocarcinoma: classification and molecular biology.
Pulmonary adenocarcinoma is increasing in incidence. Current classification systems based purely on morphological features are of little clinical relevance. Recent descriptions of genetic abnormalities, particularly in K-ras, p53, and c-erb-B2, may form the basis of a new taxonomy having direct prognostic relevance. Study of these molecular lesions has also helped to define a new pathway of tumourigenesis in the lung parenchyma, through alveolar atypical hyperplasia (AAH) to clinical adenocarcinoma.
Carey
F A
FA
D000230:Adenocarcinoma / Q000145:classification* / Q000235:genetics; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification* / Q000235:genetics; D011230:Precancerous Conditions / Q000145:classification / Q000235:genetics