title: Occult papillary thyroid carcinoma in Hashimoto's thyroiditis presenting as a metastatic bone tumor.
abstract: Some occult thyroid carcinomas are hypothesized to regress and be eventually obliterated. We report here a patient whose condition supports this hypothesis. A 51-year-old male with primary hypothyroidism due to Hashimoto's thyroiditis suffered from a rib bone tumor. He had a diffuse goiter with no nodular lesion. Serum FT4 and TSH concentrations were 0.8 ng/dl and 36.4 microU/ml on taking 100 microg/day of T4. Anti-Tg- and -TPO-Ab were strongly positive (99 and 1380 U/ml). The iodine 123 scintigraphy demonstrated clear accumulation in the rib tumor, whereas the thyroid was scarcely visible. Biopsy of the rib tumor showed papillary proliferation of large atypical cells, which were immunohistochemically positive for thyroglobulin. Metastatic bone tumor of papillary thyroid carcinoma was therefore strongly suspected. He underwent a total thyroidectomy and the thyroid was stepwise sectioned completely at 3 mm intervals. The thyroid condition was diagnosed as Hashimoto's thyroiditis demonstrating diffuse and dense fibrosis, lymphocyte infiltration with lymphoid follicles and flattened atrophied follicles, but no carcinomatous foci were found. He was treated with I-131 and scintigraphy after the ingestion showed distinct accumulation in the rib tumors similar to that before thyroidectomy. No other abnormal uptake was observed. It is suggested that the primary occult thyroid papillary carcinoma regressed and was obliterated possibly by some immunologic or other host-resistance factors after it metastasized to the distant bone.
authors.affiliation: Second Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishikawa
authors.forename: N
authors.initials: N
authors.lastname: Toyoda
authors.forename: T
authors.initials: T
authors.lastname: Yonemoto
authors.forename: A
authors.initials: A
authors.lastname: Fujiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Tokoro
authors.forename: N
authors.initials: N
authors.lastname: Sakaguchi
authors.forename: M
authors.initials: M
authors.lastname: Yoshimura
authors.forename: N
authors.initials: N
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Tabata
authors.forename: H
authors.initials: H
authors.lastname: Kumazawa
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: N
authors.initials: N
authors.lastname: Sakaida
authors.forename: A
authors.initials: A
authors.lastname: Okamura
authors.forename: K
authors.initials: K
authors.lastname: Kasagi
authors.forename: M
authors.initials: M
authors.lastname: Inada
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary; D012272:Ribs; D013964:Thyroid Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D013965:Thyroidectomy; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000473:pathology