title: Effects of thioperamide on locomotor activity and on memory processes.
abstract: 1. Rats were tested in an open field. Thioperamide given i.p. 30 minutes before the tests produced an increase of locomotor activity at 2 mg/kg and no behavioral effect at 5 mg/kg. 2. The repetition of the open field tests caused a reduction of ambulation in three successive tests. This effect was increased by thioperamide 2 and 5 mg/kg given after the tests, suggesting that this compound improved memory consolidation.
authors.affiliation: Dipartimento di Anatomia, Farmacologia e Medicina Legale Universita' di Torino, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Ghi
authors.forename: G
authors.initials: G
authors.lastname: di Carlo
authors.forename: L
authors.initials: L
authors.lastname: Molinengo
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006633:Histamine Antagonists / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006633:Histamine Antagonists; D010880:Piperidines; C052075:thioperamide