Overview of studies on metabolic and vascular regulatory changes in early diabetic retinopathy.
The present review provides an overview of recent research describing functional changes to the retinal vasculature in very early diabetes. The research focuses on the streptozotocin rat model after 4-6 weeks of induced diabetes and describes functional changes to retinal blood flow, vascular control and retinal oxygenation, as well as a strong vasodilatory response to insulin in the retinal vasculature. The review raises the question of whether choroid dysfunction is also a feature of diabetic retinopathy.
Alder
V A
VA
Lions Eye Institute and Centre for Ophthalmology and Visual Science, University of Western Australia, Nedlands, Australia. valalder@cyllene.uwa.edu.au
Su
E N
EN
Yu
D Y
DY
Cringle
S
S
Yu
P
P
D000818:Animals; D001783:Blood Flow Velocity; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D010101:Oxygen Consumption; D051381:Rats; D012171:Retinal Vessels / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D014664:Vasodilation / Q000187:drug effects
D007328:Insulin