Mechanisms of silencing in Saccharomyces cerevisiae.
In the yeast Saccharomyces cerevisiae, heterochromatin-like regions are formed at the silent mating type loci and at telomeres. The past year of investigations has led to a clearer understanding of the nature of nucleation and spreading of heterochromatin, as well as uncovering a fascinating link between silencing, the nucleolus and aging.
Lustig
A J
AJ
Department of Biochemistry, Tulane University Medical Center, New Orleans, Louisiana 70112, USA. alustig@mailhost.tcs.tulane.edu
D000818:Animals; D002466:Cell Nucleolus; D002843:Chromatin; D004260:DNA Repair; D004261:DNA Replication; D005656:Fungal Proteins / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D008024:Ligands; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D016615:Telomere; D014452:Ubiquitins / Q000378:metabolism
D002843:Chromatin; D005656:Fungal Proteins; D008024:Ligands; C061573:SIR4 protein, S cerevisiae; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D014452:Ubiquitins