Immunocytochemical localization of mu-opioid receptor in primary afferent neurons containing substance P or calcitonin gene-related peptide. A light and electron microscope study in the rat.
Co-expression of mu-opioid receptor-like immunoreactivity (MOR-LI) with substance P (SP)- or calcitonin gene-related (CGRP)-LI was observed in rat trigeminal and dorsal root ganglion neurons. In particular, MOR-LI was found in axon terminals with SP- or CGRP-LI in laminae I and II of the medullary and spinal dorsal horns. MOR may be implicated in modulation of release of SP and CGRP from primary sensory afferents.
Li
J L
JL
Department of Anatomy and K.K. Leung Brain Research Centre, Fourth Military Medical University, Xi'an 710032, China.
Ding
Y Q
YQ
Li
Y Q
YQ
Li
J S
JS
Nomura
S
S
Kaneko
T
T
Mizuno
N
N
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D005727:Ganglia, Spinal / Q000737:chemistry* / Q000166:cytology; D007150:Immunohistochemistry; D008297:Male; D008853:Microscopy / Q000379:methods; D008854:Microscopy, Electron; D009475:Neurons, Afferent / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000032:analysis*; D013373:Substance P / Q000032:analysis*; D012668:Trigeminal Ganglion / Q000737:chemistry* / Q000166:cytology
D017450:Receptors, Opioid, mu; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide