Medication take-home doses and contingency management.
Two studies examined contingent take-home medication doses during treatment of opiate or cocaine dependence. In the first study, methadone maintenance patients were randomly assigned to one of two 8-week baseline take-home (TH) conditions differing in frequency of clinic visits per week. This was followed by a 12-week contingency management (CM) procedure in which frequent THs resulted from drug-free urines. Participants receiving more frequent THs during baseline had lower illicit drug use during the first 6 weeks of CM. In the second study, fluoxetine (0-, 20-, 40-mg) TH doses were similarly contingent in treatment of cocaine dependence. The 40-mg group used less cocaine during contingency than did other groups. The combination of fluoxetine and environmental contingencies may produce benefit where neither alone is sufficient.
Schmitz
J M
JM
Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston 77030, USA. jschmitz@msi66.msi.uth.tmc.edu
Rhoades
H M
HM
Elk
R
R
Creson
D
D
Hussein
I
I
Grabowski
J
J
D000328:Adult; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage*; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000188:drug therapy* / Q000523:psychology
D005473:Fluoxetine; D008691:Methadone