Phorbol ester-mediated induction of cyclooxygenase-2 gene expression is inhibited by retinoids.
Mestre
J R
JR
Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021, USA.
Subbaramaiah
K
K
Sacks
P G
PG
Schantz
S P
SP
Dannenberg
A J
AJ
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D015152:Blotting, Northern; D015153:Blotting, Western; D002273:Carcinogens / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000378:metabolism; D051546:Cyclooxygenase 2; D015232:Dinoprostone / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D004224:Diterpenes; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D007527:Isoenzymes / Q000187:drug effects / Q000235:genetics*; D015474:Isotretinoin / Q000494:pharmacology; D008565:Membrane Proteins; D010544:Peroxidases / Q000187:drug effects / Q000235:genetics*; D010703:Phorbol Esters / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects / Q000235:genetics*; D012176:Retinoids / Q000494:pharmacology*; D000084562:Retinyl Esters; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology
D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D002273:Carcinogens; D004224:Diterpenes; D007527:Isoenzymes; D008565:Membrane Proteins; D010703:Phorbol Esters; D012176:Retinoids; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D014212:Tretinoin; D010544:Peroxidases; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D015474:Isotretinoin; D015232:Dinoprostone