[Radioprotective effect of hydroxy phenylethanolamine phenolic hydroxyl esters].
Experiments are carried out on 3000 mice, irradiated in dose 8 Gy (LD97/30). A number of phenolic hydroxyl esters of phenylephrine, norphenylephrine and epinephrine has the high RPE (70-100%) within 1 h before irradiation. 3-esters of 3-hydroxy phenylethanolamines are active in small doses (19-50 mumol/kg) and protect per os too. RPE of 3-benzoylphenylephrine realizes via alpha 1-adrenoreceptors.
Kulinskiĭ
V I
VI
Irkutsk State Medical University NPS Pharmzashchita, Himki, Russia.
Iashunskiĭ
V G
VG
Klimova
A D
AD
Alpatova
T V
TV
Kovtun
V Iu
VIu
D000284:Administration, Oral; D000818:Animals; D004837:Epinephrine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity; D004952:Esters; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010656:Phenylephrine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000633:toxicity; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000633:toxicity; D013997:Time Factors
D004952:Esters; D011837:Radiation-Protective Agents; D010656:Phenylephrine; D004837:Epinephrine
Radiozashchitnyĭ éffekt slozhnykh éfirov po fenol'nym gidroksilam oksifenilétanolaminov.