title: Effects of aspirin on angiotensin-converting enzyme inhibition and left ventricular dilation one year after acute myocardial infarction.
abstract: There are conflicting reports on the interaction of aspirin with angiotensin-converting enzyme inhibitors in heart failure and systemic hypertension. A post hoc analysis of the Captopril and Thrombolysis Study (CATS) study was conducted. At randomization, 94 patients (31.5%) took aspirin. In patients who took aspirin, the cumulative alpha-hydroxy butyrate dehydrogenase release was 1,151 +/- 132 IU/L in patients randomized to captopril compared with 1,401 +/- 136 IU/L in patients randomized to placebo (difference -250 +/- 189 [95% confidence interval (CI) -620 to 120]). This difference was comparable to the difference in patients who did not use aspirin (-199 +/- 147 [95% CI -488 to 897]). One year after acute myocardial infarction, an increase in left ventricular end-diastolic volume index of 2.2 +/- 3.0 ml/m2 in captopril-treated and 1.9 +/- 2.9 ml/m2 in placebo-treated patients was observed in patients who took aspirin (difference 0.4 +/- 4.2 [95% CI -8.2 to 8.9]). This difference was also comparable to the difference in patients who did not take aspirin (2.2 +/- 3.8 [95% CI -5.2 to 9.7]). One year after acute myocardial infarction, patients who did take aspirin had a mean change in LV end-diastolic volume index of 2.1 +/- 2.1 ml/m2 compared with 8.4 +/- 1.9 ml/m2 in patients who did not use aspirin (p = 0.02). Thus, aspirin does not attenuate the acute and long-term effects of angiotensin-converting enzyme inhibition after acute myocardial infarction, but independently reduces LV dilation after myocardial infarction.
authors.affiliation: Department Clinical Pharmacology, University of Groningen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Oosterga
authors.forename: R L
authors.initials: RL
authors.lastname: Anthonio
authors.forename: P J
authors.initials: PJ
authors.lastname: de Kam
authors.forename: J H
authors.initials: JH
authors.lastname: Kingma
authors.forename: H J
authors.initials: HJ
authors.lastname: Crijns
authors.forename: W H
authors.initials: WH
authors.lastname: van Gilst
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000493:pharmacokinetics*; D001241:Aspirin / Q000494:pharmacology*; D002216:Captopril / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000493:pharmacokinetics; D006973:Hypertension / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D016277:Ventricular Function, Left
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D010975:Platelet Aggregation Inhibitors; D002216:Captopril; D006884:Hydroxybutyrate Dehydrogenase; D001241:Aspirin