The hydroxyl radical scavenger Nicaraven inhibits glutamate release after spinal injury in rats.
Neuronal degeneration after trauma is mediated in part by release of excitatory amino acids (EAAs) and oxygen free radicals (OFR). We evaluated the effect of i.v. treatment with a hydroxyl radical scavenger ((+/-)-N,N'-propylenedinicotinamide; AVS) and spinal hypothermia (33 degrees C) on spinal CSF glutamate release after spinal trauma. In a control group, spinal compression evoked at 10 min a significant increase (5-fold) in glutamate which declined over 4 h (2.1-fold). AVS treatment attenuated glutamate release but had no additive effect. These data suggest that this compound can be effective in modulating spinal excitotoxicity resulting from increased OFR synthesis and corresponding potentiation of EAA release.
Yamamoto
K
K
Department of Anesthesiology-Resuscitology, Yamaguchi University School of Medicine, Japan.
Ishikawa
T
T
Sakabe
T
T
Taguchi
T
T
Kawai
S
S
Marsala
M
M
D000818:Animals; D016166:Free Radical Scavengers / Q000494:pharmacology*; D018698:Glutamic Acid / Q000134:cerebrospinal fluid*; D017665:Hydroxyl Radical; D007036:Hypothermia, Induced; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000134:cerebrospinal fluid*; D013997:Time Factors
D016166:Free Radical Scavengers; D009536:Niacinamide; D017665:Hydroxyl Radical; D018698:Glutamic Acid; C042625:nicaraven