Torilin, a sesquiterpene from Torilis japonica, reverses multidrug-resistance in cancer cells.
A sesquiterpene compound reversing multidrug-resistance in cancer cells was isolated from the fruits of Torilis japonica and the structure was identified as torilin. Torilin potentiated the cytotoxicities of adriamycin, vinblastine, taxol and colchicine against multidrug-resistant KB-V1 and MCF7/ADR cells.
Kim
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Natural Product Biosynthesis RU., Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea.
Kim
Y H
YH
Kim
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YC
Lee
J J
JJ
D000970:Antineoplastic Agents / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D006801:Humans; D017239:Paclitaxel / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane; D014407:Tumor Cells, Cultured; D014747:Vinblastine / Q000494:pharmacology
D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; D014747:Vinblastine; D004317:Doxorubicin; D017239:Paclitaxel; C112694:torilin; D003078:Colchicine