title: Study of left ventricular bypass using Wankel type semipulsatile blood pump.
abstract: The influence of the Wankel type semipulsatile left ventricular assistance on hemodynamics was investigated with a computer simulation and an animal experiment. A simulation circuit was constructed to express the circulatory system. A current source was added to create a semipulsatile blood pump. The left and right ventricles were replaced by variable compliances. Left heart failure was simulated by decreasing the amount of compliance change of the left ventricle. Under the condition of heart failure when semipulsatile assist flow increased, the mean aortic pressure (AoP), tension time index (TTI), and diastolic pressure time index (DPTI) increased, and the cardiac output, pulse pressure (PP), and pulsatility indicator (PI) decreased. In an animal experiment, a Wankel type blood pump was used in a calf. With the increase of the assist flow, AoP curves became less pulsatile, and PP and PI decreased in accordance, which was predicted by the numerical simulation.
authors.affiliation: First Department of Surgery, Hiroshima University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Mitsui
authors.forename: S
authors.initials: S
authors.lastname: Fukunaga
authors.forename: T
authors.initials: T
authors.lastname: Sueda
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuura
authors.forename: P
authors.initials: P
authors.lastname: Havlik
authors.forename: J
authors.initials: J
authors.lastname: Trinkl
authors.forename: J L
authors.initials: JL
authors.lastname: Demunck
authors.forename: T
authors.initials: T
authors.lastname: Mesana
authors.forename: J R
authors.initials: JR
authors.lastname: Montiès
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002417:Cattle; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology*; D004562:Electrocardiography; D006333:Heart Failure / Q000503:physiopathology; D006353:Heart-Assist Devices; D008954:Models, Biological; D011673:Pulsatile Flow; D016276:Ventricular Function