title: Dynamic changes of 12-lead electrocardiograms in a patient with Brugada syndrome.
abstract: We present a patient with Brugada syndrome in whom 12-lead ECGs were recorded just before and after an episode of ventricular fibrillation (VF). A progressive elevation of both the RS-T segment and J waves just preceding and following the VF, and a close relationship between the amplitude of the RS-T segment and the preceding R-R intervals during atrial fibrillation, were documented. These findings support the hypothesis that RS-T elevation and a subsequent VF are related to a transient outward current-mediated spike-and-dome morphology of the epicardial action potential.
authors.affiliation: Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
authors.forename: W
authors.initials: W
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Kurita
authors.forename: M
authors.initials: M
authors.lastname: Inagaki
authors.forename: N
authors.initials: N
authors.lastname: Aihara
authors.forename: S
authors.initials: S
authors.lastname: Kamakura
mesh_terms: D000328:Adult; D002037:Bundle-Branch Block / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D004562:Electrocardiography / Q000379:methods; D006801:Humans; D008297:Male; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000503:physiopathology*