[Different sensitivity biochemical mechanisms to mycobacterium tuberculosis of guinea pigs and rats].
Mycobacterium tuberculosis (MT) (H37Rv strain, 0.1 mg) was subcutaneously administered to guinea-pigs and rats and 6 weeks later the content of free amino acids and oxidized and reduced glutahione were measured in the liver. The guinea-pigs were found to have higher levels of phosphoethanolamine (PEA), ethanolamine (EA), serine, and phenylalanine and lower concentrations of tyrosine. These changes are regarded as a sign of damaged cell membranes and impaired redox processes in the development of experimental tuberculosis (ET) in guinea-pigs. The compensatory adaptation in ET was increased levels of reduced glutathione and taurine. In intact rats, the hepatic level of taurine was 5 times higher and that of oxidized and reduced glutathione was twice less than in guinea-pigs. Rats did not develop ET, in them the level of taurine increased by twice more, that of PEA, EA, serine drastically dropped. Species-specific differences in the MT sensitivity of guinea-pigs and rats seem to be due to the differences in the levels of taurine.
Pavlov
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D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000378:metabolism / Q000382:microbiology; D019856:Ethanolamine / Q000378:metabolism; D004983:Ethanolamines / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006168:Guinea Pigs; D008099:Liver / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D010084:Oxidation-Reduction; D051381:Rats; D013045:Species Specificity; D014397:Tuberculosis, Pulmonary / Q000378:metabolism* / Q000382:microbiology; D014774:Virulence
D000596:Amino Acids; D004983:Ethanolamines; D019856:Ethanolamine; C005448:phosphorylethanolamine; D005978:Glutathione
O biokhimicheskikh mekhanizmakh razlichnoĭ chuvstvitel'nosti k mikobakteriiam tuberkuleza morskikh svinok i krys.