title: First-pass radionuclide angiography using iodine-123 myocardial tracers and a multicrystal gamma camera.
abstract: The purpose of this study was to validate the accuracy of the assessment of ventricular function by first-pass radionuclide angiography (FPRNA) with 123I myocardial tracers and a multicrystal gamma camera.
  
  
  METHODS
  Left ventricular ejection fraction (LVEF) and right ventricular ejection fraction were measured in 69 patients by FPRNA using 123I myocardial tracers (126 +/- 7 MBq) and 99mTc tracers (541 +/- 141 MBq) on a multicrystal gamma camera with a high-sensitivity collimator. For 44 patients, ejection fraction values measured by 123I-FPRNA were compared to those estimated by equilibrium radionuclide angiography (ERNA). Visual wall-motion analysis was also performed to judge clinical acceptability of 123I-FPRNA images for identification of wall-motion abnormality.
  
  
  RESULTS
  Mean LVEFs (%) estimated by 123I-FPRNA and by 99mTc-FPRNA were 49.6 +/- 13.6 and 49.1 +/- 14.1, respectively (nonsignificant p value). An excellent correlation was found between LVEFs estimated by 123I-FPRNA and 99mTc-FPRNA (r = 0.96, s.e.e. = 1.9%). Values of LVEF measured by 123I-FPRNA also demonstrated excellent correlation with those measured by ERNA (r = 0.95, s.e.e. = 2.2%). A good correlation was also noted between right ventricular ejection fractions measured by 123I-FPRNA and 99mTc-FPRNA (r = 0.72, s.e.e. = 4.0%). The Spearman rank correlation coefficient between 123I-FPRNA and ERNA wall-motion scores was 0.87 (n = 135, p < 0.001).
  
  
  CONCLUSIONS
  Resting ventricular function can be reliably measured with 123I-FPRNA in combination with a multicrystal gamma camera. This indicates that the assessment of ventricular function is feasible in conjunction with 123I myocardial imaging without an increase in cost or radiation dose to patients.
authors.affiliation: Department of Nuclear Medicine, Kyoto University Faculty of Medicine, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Tadamura
authors.forename: H
authors.initials: H
authors.lastname: Kitano
authors.forename: T
authors.initials: T
authors.lastname: Kudoh
authors.forename: N
authors.initials: N
authors.lastname: Hattori
authors.forename: M
authors.initials: M
authors.lastname: Inubushi
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: I
authors.initials: I
authors.lastname: Masuda
authors.forename: H
authors.initials: H
authors.lastname: Inada
authors.forename: R
authors.initials: R
authors.lastname: Hosokawa
authors.forename: R
authors.initials: R
authors.lastname: Nohara
authors.forename: J
authors.initials: J
authors.lastname: Konishi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015902:Gamma Cameras; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D013318:Stroke Volume; D016276:Ventricular Function; D015646:Ventriculography, First-Pass / Q000379:methods
chemical_list: D007457:Iodine Radioisotopes