title: Effects of azoxymethane on X-ray induced intestinal metaplasia in Donryu rats.
abstract: The present study was undertaken to determine the effect of azoxymethane (AOM) administration on intestinal metaplasia induced by X-irradiation in male Donryu rats. Five-week-old animals were X-irradiated with two doses of 10 Gy each at a 3-day interval or three X-ray doses of 10 Gy at a 2-day interval and then received AOM injections i.m. at a dose of 15 mg/kg body weight once weekly for 3 weeks, 6 months after irradiation. Alkaline phosphatase positive foci were decreased after AOM treatments, but aberrant crypt like-foci appeared within areas of intestinal metaplasia. In contrast no induction was observed in normal-appearing gastric mucosa.
authors.affiliation: Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima, 734-8553, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Fujimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Masaoka
authors.forename: M
authors.initials: M
authors.lastname: Kurosumi
authors.forename: T
authors.initials: T
authors.lastname: Oguri
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Kido
authors.forename: S
authors.initials: S
authors.lastname: Hirata
authors.forename: K
authors.initials: K
authors.lastname: Kuramoto
authors.forename: S
authors.initials: S
authors.lastname: Shoji
authors.forename: O
authors.initials: O
authors.lastname: Katoh
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001397:Azoxymethane / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D007422:Intestines / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D008297:Male; D008679:Metaplasia / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002273:Carcinogens; D000469:Alkaline Phosphatase; D001397:Azoxymethane