title: Prevalence of diabetes-specific autoantibodies in patients at risk for adult onset diabetes mellitus.
abstract: To evaluate the potential of autoimmune markers in identifying patients with slowly progressive IDDM in the prediabetic state, we screened a population of 151 patients aged 37-70 years with impaired glucose tolerance (IGT) for the presence of islet cell antibodies (ICA), insulin autoantibodies (IAA), antibodies to glutamic acid decarboxylase (GADA), and antibodies to tyrosine phosphatase IA-2 (IA-2A). Autoantibodies were found in 5 (3.3%) patients with IGT suggesting the presence of an autoimmune-mediated beta cell destruction. All of them were positive for high level ICA (> 20 JDF-U) and 1 ICA positive subject had additional GADA (100 GADA-U). In contrast, none of the subjects had IA-2A or IAA. We here demonstrate a low prevalence of autoimmune diabetes among middle-aged subjects with IGT. ICA and GADA but not IA-2A or IAA may represent autoimmune markers for slowly progressive IDDM before the manifestation of the disease.
authors.affiliation: Department of Internal Medicine and Policlinic I, Dresden. breidert@rcs.urz.tu-dresden.de
authors.forename: M
authors.initials: M
authors.lastname: Breidert
authors.forename: T
authors.initials: T
authors.lastname: Temelkova-Kurktschiev
authors.forename: M
authors.initials: M
authors.lastname: Hanefeld
authors.forename: W
authors.initials: W
authors.lastname: Leonhardt
authors.forename: A
authors.initials: A
authors.lastname: Schmoeckel
authors.forename: J
authors.initials: J
authors.lastname: Seissler
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D005858:Germany / Q000453:epidemiology; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001323:Autoantibodies; D002096:C-Peptide; D007328:Insulin; C024211:islet cell antibody; D005968:Glutamate Decarboxylase