title: Predictive docking of protein-protein and protein-DNA complexes.
abstract: Recent developments in algorithms to predict the docking of two proteins have considered both the initial rigid-body global search and subsequent screening and refinement. The result of two blind trials of protein docking are encouraging--for complexes that are not too large and do not undergo sizeable conformational change upon association, the algorithms are now able to suggest reasonably accurate models.
authors.affiliation: Biomolecular Modelling Laboratory, Imperial Cancer Research Fund, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Sternberg
authors.forename: H A
authors.initials: HA
authors.lastname: Gabb
authors.forename: R M
authors.initials: RM
authors.lastname: Jackson
mesh_terms: D000465:Algorithms; D000818:Animals; D000906:Antibodies / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D006388:Hemagglutinins / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D046911:Macromolecular Substances; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism
chemical_list: D000906:Antibodies; D004791:Enzyme Inhibitors; D006388:Hemagglutinins; D046911:Macromolecular Substances; D011506:Proteins; D065093:beta-Lactamase Inhibitors; D004247:DNA; D001618:beta-Lactamases