title: The CRH-ACTH-biogenic amine axis in invertebrate immunocytes activated by PDGF and TGF-beta.
abstract: In immunocytes from the mollusc Mytilus galloprovincialis, the major pathway followed by platelet-derived growth factor (PDGF)-AB and transforming growth factor (TGF)-beta1 in provoking the release of norepinephrine, epinephrine and dopamine into cell-free hemolymph (serum) is mediated by a corticotropin-releasing hormone-adrenocorticotropin hormone (CRH-ACTH) biogenic amine axis. This axis not only annulled the inhibiting properties of PDGF-AB, it even reversed the latter's effect, while the inducing effect of TGF-beta1 was amplified. These findings show that non-classical immune-neuroendocrine molecules, such as PDGF-AB and TGF-beta1, are involved in building stress response, using the same conserved mechanisms present from invertebrates to vertebrates.
authors.affiliation: Department of Animal Biology, University of Modena, Italy. enzott@unimo.it
authors.forename: E
authors.initials: E
authors.lastname: Ottaviani
authors.forename: E
authors.initials: E
authors.lastname: Caselgrandi
authors.forename: D
authors.initials: D
authors.lastname: Kletsas
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001679:Biogenic Amines / Q000096:biosynthesis*; D049872:Bivalvia; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D006458:Hemolymph; D007375:Interleukin-1 / Q000494:pharmacology; D009479:Neuropeptides / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D013312:Stress, Physiological / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
chemical_list: D001679:Biogenic Amines; D007375:Interleukin-1; D009479:Neuropeptides; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; C095477:platelet-derived growth factor AB; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone