Evaluation of kinetic parameters of natural phytoalexin in resveratrol orally administered in wine to rats.
In view of the increasing interest in the biological activity of resveratrol, one of the components of red wine which is considered to be one of the main ingredients responsible for the beneficial effect of wine on human health, we have studied plasma kinetics and tissue bioavailability of this compound after red wine oral administration in rats. Plasma pharmacokinetics after oral administration of resveratrol could be described by an open one- or two-compartment model. Tissue concentrations show a significant cardiac bioavailability, and a strong affinity for the liver and kidneys.
Bertelli
A A
AA
Institute of Anatomy, University of Milan, Milan, Italy.
Giovannini
L
L
Stradi
R
R
Urien
S
S
Tillement
J P
JP
Bertelli
A
A
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D005069:Evaluation Studies as Topic; D008297:Male; D008657:Metabolic Clearance Rate; D010936:Plant Extracts / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D012717:Sesquiterpenes; D013267:Stilbenes / Q000737:chemistry*; D013729:Terpenes; D014920:Wine; D000094162:Phytoalexins
D010936:Plant Extracts; D012717:Sesquiterpenes; D013267:Stilbenes; D013729:Terpenes; D000077185:Resveratrol; D000094162:Phytoalexins