title: Lipid profile of rats fed blends of rice bran oil in combination with sunflower and safflower oil.
abstract: This study was undertaken to assess the effect of blended oils, i.e., polyunsaturated fatty acid (PUFA) rich vegetable oils like safflower oil (SFO) and sunflower oil (SNO) with the unconventional and hypocholesterolemic rice bran oil (RBO) on the serum lipid profile of rats. Rats fed RBO+SNO/SFO at 70:30 ratio for a period of 28 days showed significantly (p < 0.05) lower levels of total cholesterol (TC), triglycerides (TG) and low density lipoprotein (LDL) cholesterol and increased high density lipoprotein (HDL) cholesterol in animals fed a high cholesterol diet (HCD) and cholesterol free diet (CFD). Liver total cholesterol (TC) and triglycerides (TG) were also reduced. Fecal excretion of neutral sterols and bile acids was increased with use of RBO blends. RBO, which is rich in tocopherols and tocotrienols, may improve the oxidative stability of the blends. Tocotrienols are known to inhibit 3-hydroxy, 3-methyl, glutaryl CoA (HMG-COA) reductase (rate limiting enzyme in cholesterol biosynthesis), resulting in hypocholesterolemia. In addition to improving the lipid profile by lowering TC, TG and LDL-C and increasing HDL-C, blending of RBO with other oils can result in an economic advantage of lower prices.
authors.affiliation: Department of Foods and Nutrition, Post Graduate and Research Centre, Acharya N.G. Ranga, Agriculture University, Rajendranagar, Hyderabad, India.
authors.forename: T
authors.initials: T
authors.lastname: Sunitha
authors.forename: R
authors.initials: R
authors.lastname: Manorama
authors.forename: C
authors.initials: C
authors.lastname: Rukmini
mesh_terms: D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D005243:Feces / Q000737:chemistry; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000073879:Rice Bran Oil; D012450:Safflower Oil / Q000008:administration & dosage / Q000378:metabolism; D000074242:Sunflower Oil; D015430:Weight Gain / Q000187:drug effects
chemical_list: D002791:Cholesterol, Dietary; D004042:Dietary Fats, Unsaturated; D008055:Lipids; D010938:Plant Oils; D000074242:Sunflower Oil; D012450:Safflower Oil; D000073879:Rice Bran Oil