title: Influence of radioiodine therapy on urinary iodine excretion.
abstract: OBJECTIVE
  In 214 patients with benign thyroid diseases the time-course of urinary iodine excretion (UIE) was investigated in order to identify changes after radioiodine therapy (RITh).
  
  
  METHODS
  UIE was measured photometrically (cerium-arsenite method) and related to urinary creatinine on the first and last day of the radioiodine test and then three days, seven days, four weeks, and six months after 131I administration.
  
  
  RESULTS
  As compared with the level found immediately before radioiodine therapy, median UIE had almost doubled four weeks after therapy and was still significantly elevated six months after therapy. This increase correlated significantly with the target volume as measured by scintigraphy and sonography.
  
  
  CONCLUSIONS
  The persistent elevation of UIE for months after RITh is a measure of treatment-induced damage to thyrocytes. Therefore, in view of the unfavourable kinetics of iodine that follow it, RITh should if possible be given via a single-dose regime.
authors.affiliation: Department of Radiotherapy and Nuclear Medicine, Medical University of Lübeck, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Meller
authors.forename: I
authors.initials: I
authors.lastname: Lauer
authors.forename: M
authors.initials: M
authors.lastname: Bähre
authors.forename: E
authors.initials: E
authors.lastname: Richter
mesh_terms: D013956:Antithyroid Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007455:Iodine / Q000652:urine*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012044:Regression Analysis; D013959:Thyroid Diseases / Q000188:drug therapy / Q000532:radiotherapy* / Q000652:urine; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors
chemical_list: D013956:Antithyroid Agents; D007457:Iodine Radioisotopes; D007455:Iodine