title: Overview of studies on metabolic and vascular regulatory changes in early diabetic retinopathy.
abstract: The present review provides an overview of recent research describing functional changes to the retinal vasculature in very early diabetes. The research focuses on the streptozotocin rat model after 4-6 weeks of induced diabetes and describes functional changes to retinal blood flow, vascular control and retinal oxygenation, as well as a strong vasodilatory response to insulin in the retinal vasculature. The review raises the question of whether choroid dysfunction is also a feature of diabetic retinopathy.
authors.affiliation: Lions Eye Institute and Centre for Ophthalmology and Visual Science, University of Western Australia, Nedlands, Australia. valalder@cyllene.uwa.edu.au
authors.forename: V A
authors.initials: VA
authors.lastname: Alder
authors.forename: E N
authors.initials: EN
authors.lastname: Su
authors.forename: D Y
authors.initials: DY
authors.lastname: Yu
authors.forename: S
authors.initials: S
authors.lastname: Cringle
authors.forename: P
authors.initials: P
authors.lastname: Yu
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D010101:Oxygen Consumption; D051381:Rats; D012171:Retinal Vessels / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D007328:Insulin