Immunoperoxidase staining in the differential diagnosis of parathyroid from thyroid origin in fine needle aspirates of suspected parathyroid lesions.
OBJECTIVE
To determine whether immunoperoxidase staining could be used for differential diagnosis of parathyroid from thyroid origin in fine needle aspirates of suspected parathyroid lesions.


METHODS
Immunoperoxidase staining of parathyroid hormone and thyroglobulin was performed on aspirated smears from 10 patients with parathyroid lesions (6 of 10 patients also associated with thyroid lesions) and 10 patients with thyroid lesions. All of them had surgical tissue proof of the diagnosis.


RESULTS
Aspirated smears of six patients with parathyroid lesions had strong to moderate staining for parathyroid hormone and negative staining for thyroglobulin. Another four patients with parathyroid lesions had equivocal staining for parathyroid hormone and negative staining for thyroglobulin. All aspirated smears from the 16 thyroid lesions had negative staining for parathyroid hormone and positive staining for thyroglobulin.


CONCLUSIONS
Immunoperoxidase staining of parathyroid hormone and thyroglobulin, done for each suspected parathyroid lesion, was helpful in the differential diagnosis of parathyroid vs. thyroid origin.
Chang
T C
TC
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
Tung
C C
CC
Hsiao
Y L
YL
Chen
M H
MH
D000236:Adenoma / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D015415:Biomarkers; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D006044:Goiter, Nodular / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000473:pathology; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D009363:Neoplasm Proteins / Q000032:analysis; D010280:Parathyroid Glands / Q000473:pathology; D010281:Parathyroid Hormone / Q000032:analysis*; D010282:Parathyroid Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D013954:Thyroglobulin / Q000032:analysis*; D014463:Ultrasonography
D015415:Biomarkers; D009363:Neoplasm Proteins; D010281:Parathyroid Hormone; D013954:Thyroglobulin