Cytokine gene therapy for human tumors.
Cytokine gene therapy is a potentially powerful antineoplastic strategy. It provides paracrine cytokine secretion in the region of putative tumor antigen that maximizes antitumor immune responses and minimizes systemic toxicity. A wealth of animal experimentation has demonstrated the effectiveness of cytokine gene therapy in a variety of tumor models. Enough evidence has mounted such that human cytokine gene therapy trials are underway throughout the United States and elsewhere.
D'Angelica
M
M
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Fong
Y
Y
D019496:Cancer Vaccines; D016207:Cytokines; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000628:therapy*
D019496:Cancer Vaccines; D016207:Cytokines