title: Etiology of anovulation in polycystic ovary syndrome.
abstract: Various endocrine factors may contribute to the phenomenon of arrested follicular development, which is the hallmark of anovulatory infertility in polycystic ovary syndrome. Hypersecretion of luteinizing hormone and/or insulin, together with high intrafollicular concentrations of androgens, can interact to produce supraphysiological levels of cyclic AMP in granulosa cells, resulting in premature activation of terminal differentiation and, hence, arrest of follicle growth.
authors.affiliation: Division of Paediatrics, Obstetrics and Gynaecology, Imperial College of Science, Technology and Medicine, St. Mary's Hospital, London, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Franks
authors.forename: H
authors.initials: H
authors.lastname: Mason
authors.forename: D
authors.initials: D
authors.lastname: White
authors.forename: D
authors.initials: D
authors.lastname: Willis
mesh_terms: D000858:Anovulation; D005260:Female; D006801:Humans; D006080:Ovarian Follicle / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*