Effects of bile acids on hepatocellular signaling and secretion.
Bile acids modulate hepatocellular signaling pathways in vitro at physiological concentrations. The present paper provides a brief overview of the effects of bile acids on three key messengers in liver cells: cytosolic free calcium, protein kinase A and protein kinase C.
Beuers
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Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany. beuers@med2.med.uni-muenchen.de
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004075:Diglycerides / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D011493:Protein Kinase C / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology / Q000502:physiology
D001647:Bile Acids and Salts; D004075:Diglycerides; D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C; D002118:Calcium