Secnidazole vs. paromomycin: comparative antiprotozoan treatment in captive primates.
The antiprotozoan activity of secnidazole was studied in Cercocebus t. torquatus, Cercopithecus campbelli, Erythrocebus patas (Cercopithecidae), and Gorilla gorilla (Pongidae) compared with that of paromomycin in Cercocebus t. lunulatus (Cercopithecidae), E. patas, and G. gorilla (Pongidae) by coprological analysis. The antiprotozoan activity of both drugs depended on the parasite species and the host species. The drugs acted in a similar way on Entamoeba coli parasitising C. t. torquatus, and E. patas. This activity was different from that observed on I. buestchlii from the same host species. Nevertheless, E. coli parasitising cercopithecids and pongids responded to drugs differently.
Gracenea
M
M
Laboratori de Parasitologia, Facultat de Farmàcia, Universitat de Barcelona, Agda. Diagonal, Spain. gracenea@farmacia.far.ub.es
Gómez
M S
MS
Fernández
J
J
Feliu
C
C
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002520:Cercopithecidae; D004747:Entamoeba / Q000302:isolation & purification; D004749:Entamoebiasis / Q000188:drug therapy / Q000662:veterinary; D015186:Hominidae; D008795:Metronidazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010303:Paromomycin / Q000627:therapeutic use*; D018419:Primate Diseases; D011323:Primates; D011529:Protozoan Infections, Animal / Q000145:classification / Q000188:drug therapy*
D000981:Antiprotozoal Agents; D008795:Metronidazole; D010303:Paromomycin; C016724:secnidazole