title: The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26.
abstract: Polyspecific transporters for organic cations (OCT) belong to a new protein family which also include organic anion transporters. The first human transporters from this family (OCT1, OCT2) have been recently cloned. They translocate small cations like tetraethylammonium, choline and monoamine neurotransmitters and are involved in hepatic and renal cation excretion, respectively. We have localized the OCT1 and OCT2 genes (SLC22A1, SLC22A2) on chromosome 6q26.
authors.affiliation: Department of Human Genetics, University of Würzburg, Biozentrum, Germany.
authors.forename: M R
authors.initials: MR
authors.lastname: Koehler
authors.forename: B
authors.initials: B
authors.lastname: Wissinger
authors.forename: V
authors.initials: V
authors.lastname: Gorboulev
authors.forename: H
authors.initials: H
authors.lastname: Koepsell
authors.forename: M
authors.initials: M
authors.lastname: Schmid
mesh_terms: D002352:Carrier Proteins / Q000235:genetics*; D056404:Chaperonin Containing TCP-1; D018833:Chaperonins; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics*; D027701:Organic Cation Transport Proteins; D000075102:Organic Cation Transporter 2; D016133:Polymerase Chain Reaction
chemical_list: D002352:Carrier Proteins; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D027701:Organic Cation Transport Proteins; D000075102:Organic Cation Transporter 2; C491013:SLC22A2 protein, human; D056404:Chaperonin Containing TCP-1; D018833:Chaperonins