Superoxide dismutase (SOD) for mustard gas burns.
Mustard gas (MS) has been used in chemical warfare since World War I. The blistering skin lesions are slow to heal. Secondary inflammation might occur, as well as damage to organs distant from the original wound. Presently there is no specific antidote for burns and poisoning by MS. This study examined treatment modalities with free oxygen radical scavengers, copper-zinc, and manganese superoxide dismutase (SOD), for MS skin burns in an experimental guinea pig model. Each of the SOD compounds reduced dramatically burn lesion area when administered intraperitoneally/intralesionally (i.p./i.l.) before wound infliction. The protective action of the SODs was also evident in the significantly higher histopathological score of biopsies obtained on day 7 from local tissue, caused with the lower dose of MS. When the SOD compounds were administered i.p. 1 hour after burn infliction, and repeated daily for 7 days, no protective effect could be detected under the present experimental conditions.
Eldad
A
A
The Burn Unit, The Department of Plastic Surgery, School of Pharmacology, The Hebrew University, Jerusalem, Israel.
Ben Meir
P
P
Breiterman
S
S
Chaouat
M
M
Shafran
A
A
Ben-Bassat
H
H
D000818:Animals; D001706:Biopsy; D002057:Burns, Chemical / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002619:Chemical Warfare Agents / Q000633:toxicity*; D005260:Female; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006168:Guinea Pigs; D015552:Injections, Intralesional; D007274:Injections, Intraperitoneal; D009151:Mustard Gas / Q000633:toxicity*; D012867:Skin / Q000187:drug effects*; D012871:Skin Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
D002619:Chemical Warfare Agents; D016166:Free Radical Scavengers; D013482:Superoxide Dismutase; D009151:Mustard Gas