title: [Energy expenditure in patients with pulmonary emphysema].
abstract: We evaluated resting energy expenditure (REE) using canopy mode indirect calorimetry in 21 ambulatory, clinically stable outpatients with pulmonary emphysema (age: 69.3 +/- 8.4, %IBW: 79.3 +/- 12.5, FEV1: 0.98 +/- 0.36) and compared it with that of a 14 age-matched healthy controls (age: 71.1 +/- 6.0, %IBW: 94.5 +/- 13.4). We also compared REE in malnourished patients (%IBW < 90; 73.0 +/- 7.6, N = 14) and normonourished patients (%IBW > or = 90; 92.0 +/- 5.6, N = 7). We examined the relation ship between %REE (REE/REEpred. x 100) and measurements of lung function tests in 21 emphysema patients using single regression analysis. The REE of the patient group was significantly higher than that of the control group (%REE; 115.9 +/- 12.0 vs 86.5 +/- 8.7, p < 0.01). The REE of the malnourished patient subgroup was significantly higher than that of the normonourished patient subgroup (%REE; 121.9 +/- 7.9 vs 109.9 +/- 9.2, p < 0.01). There were no significant differences in FEV1(L), RV/TLC(%), TLC(pred.%) or DLco/VA (pred.%) between the two patient subgroups. The REE of the normonourished subgroup was significantly higher than that of control group (%REE; 109.1 +/- 9.2 vs 86.5 +/- 8.7, p < 0.01). There were significant relations hips among %REE and FEV1, %FVC, FEV1% G, %DLco/VA and RV/TLC (p < .05). These findings suggest that elevated REE may have a significant relation ship with abnormal lung function, and that elevated REE may be a cause of malnutrition in clinically stable patients with pulmonary emphysema.
authors.affiliation: Second Department of Internal Medicine, Nara Medical University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Fu
authors.forename: T
authors.initials: T
authors.lastname: Yoneda
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: H
authors.initials: H
authors.lastname: Takenaka
authors.forename: T
authors.initials: T
authors.lastname: Tokuyama
authors.forename: K
authors.initials: K
authors.lastname: Tsukaguchi
authors.forename: C
authors.initials: C
authors.lastname: Yamamoto
authors.forename: N
authors.initials: N
authors.lastname: Narita
authors.forename: K
authors.initials: K
authors.lastname: Tomoda
authors.forename: S
authors.initials: S
authors.lastname: Cho
mesh_terms: D000368:Aged; D001835:Body Weight; D002908:Chronic Disease; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000209:etiology; D011656:Pulmonary Emphysema / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D012129:Respiratory Function Tests