title: Liddle's syndrome in an elderly woman.
abstract: A 78-year-old woman with hypertension was hospitalized with acute bronchitis. However, she was also found to have hypernatremia, hypokalemia, and metabolic alkalosis. Detailed examination showed a low plasma renin activity and plasma aldosterone concentration. A provisional diagnosis of Liddle's syndrome was established and the patient was successfully treated with triamterene. Although Liddle's syndrome is generally considered an inherited hypertensive disease found in young people, a review of the literature indicated that muscle weakness is an important clinical finding in elderly patients with this disease. Liddle's syndrome should be considered in the differential diagnosis of hypertension even in elderly individuals.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto.
authors.forename: T
authors.initials: T
authors.lastname: Matsushita
authors.forename: Y
authors.initials: Y
authors.lastname: Miyahara
authors.forename: M
authors.initials: M
authors.lastname: Matsushita
authors.forename: K
authors.initials: K
authors.lastname: Yakabe
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Furukawa
authors.forename: T
authors.initials: T
authors.lastname: Iwasaki
authors.forename: T
authors.initials: T
authors.lastname: Naito
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Ogata
authors.forename: Y
authors.initials: Y
authors.lastname: Ohzono
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000368:Aged; D000450:Aldosterone / Q000097:blood / Q000172:deficiency; D000471:Alkalosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D003937:Diagnosis, Differential; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006955:Hypernatremia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007008:Hypokalemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D011188:Potassium / Q000627:therapeutic use; D012083:Renin / Q000097:blood / Q000172:deficiency; D013577:Syndrome; D014223:Triamterene / Q000627:therapeutic use
chemical_list: D004232:Diuretics; D000450:Aldosterone; D012083:Renin; D011188:Potassium; D014223:Triamterene