Allergenic sesquiterpene lactones from Eupatorium cannabinum L. and Kaunia rufescens (Lund ex de Candolle).
From Eupatorium cannabinum L., a hitherto unknown alpha-methylene-gamma-butyrolactone, 3 beta-peroxyeucannabinolide, was isolated. This compound and eupatoriopicrin from the same plant showed a weak sensitizing capacity in guinea pigs. 2-oxoludartin and dehydroleucodin, isolated from Kaunia rufescens (syn. Eupatorium rufescens), were strong sensitizers in the same sensitizarian procedure.
Rücker
G
G
Pharmazeutisches Institut der Universität Bonn, Germany.
Schenkel
E P
EP
Manns
D
D
Mayer
R
R
Hausen
B M
BM
Heiden
K
K
D000485:Allergens / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D002186:Cannabinoids; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000209:etiology; D007783:Lactones / Q000737:chemistry / Q000633:toxicity*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000633:toxicity*; D013057:Spectrum Analysis
C113410:2-oxoludartin; C113409:3-peroxyeucannabinolide; D000485:Allergens; D002186:Cannabinoids; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; C079949:dehydroleucodine