[Radioprotective effectiveness of indralin in local gamma irradiation of the skin].
In experiment with mice radioprotective properties of indralin were investigated on local application of the substance at the site of the hind to be exposed to gamma-60Co-rays in the doses of 16.7-39.0 Gy at rate of the dose -1.5-1.6 Gy/min. After s.c. injection (50, 100, 200 and 300 mg/kg) radioprotective efficiency of indralin in term of DRF was 1.35, 1.50, 1.35 and 1.05 for early radiation damages of the skin, -1.13, 1.62, 1.53 and 1.45 for late radiation contracture of the leg, -1.10, 1.50, 1.20 and 1.16 for radiation amputation of the foot. Under 3-fold every 2 days fractionated irradiation in total dose of 42.9 Gy radioprotective efficiency of indralin in term of DRF made 1.62 for early radiation damages of skin, -1.52 for radiation oedema of the foot, > 1.5 for radiation contracture of leg. After external cutaneous application of indralin solution on 70% DMSO solvent radioprotective efficiency of the drug in term of DRF was 1.28 and 1.37 for early and late radiation damages of skin while DRF of DMSO being equal to 1.14 and 1.22 responsively.
Vasin
M V
MV
State Research Testing Institute of Aviation and Space Medicine, Ministry of Defence of Russian Federation, Moscow.
Ushakov
I B
IB
Suvorov
N N
NN
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003037:Cobalt Radioisotopes / Q000008:administration & dosage; D003286:Contracture / Q000209:etiology / Q000517:prevention & control; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D019583:Dose Fractionation, Radiation; D005121:Extremities; D005260:Female; D051379:Mice; D008962:Models, Theoretical; D010636:Phenols / Q000008:administration & dosage; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D011855:Radiodermatitis / Q000517:prevention & control*; D012867:Skin / Q000187:drug effects / Q000528:radiation effects*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D003037:Cobalt Radioisotopes; D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin; D004121:Dimethyl Sulfoxide
Protivoluchevaia éffektivnost' indralina pri lokal'nom gamma-obluchenii kozhi.