[Mechanism of the growth and rupture of abdominal aortic aneurysm].
The relationship between atherosclerosis and abdominal aortic aneurysm development is well known. Atherosclerosis cannot explain the whole mechanism. Genetic characters of mechanisms leading to abdominal aortic development is obvious from this study and others. Our study evidences an increased metalloproteases activity in aortic wall proportionally to the size of the abdominal aortic aneurysm. A decrease of aortic wall elastin is evidenced proportionally to the AAA size. Extractable collagen is significantly increased in the aortic wall of patients operated on for aortic rupture.
Limet
R
R
C.H.U. du Sart-Tilman, Université de Liège.
Sakalihasan
N
N
Lapière
C M
CM
D000367:Age Factors; D000368:Aged; D001012:Aorta, Abdominal / Q000737:chemistry / Q000201:enzymology; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D001019:Aortic Rupture / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D001161:Arteriosclerosis / Q000150:complications*; D004549:Elastin / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008666:Metalloendopeptidases / Q000378:metabolism; D008875:Middle Aged
D004549:Elastin; D008666:Metalloendopeptidases
Mécanisme de croissance et de rupture des anévrysmes de l'aorte abdominale.