title: Transurethral electrovaporization of the prostate vs. transurethral resection. Results of a multicentric, randomized clinical study on 150 patients.
abstract: OBJECTIVE
  To evaluate clinical, urodynamic efficacy and safety of TURP and TVP in patients with symptoms due to obstructive benign prostatic hypertrophy with a prospective multicentric randomized study.
  
  
  METHODS
  150 patients with BPH, urodynamically obstructed, were randomized to receive TURP or TVP. At the end of the recruitment phase, 80 patients underwent TURP and 70 patients underwent TVP. Patients were clinically evaluated by the I-PSS score at months 0, 1, 3, 6 and 12. Preoperative evaluation included complete blood routine examination, PSA, transrectal ultrasound and pressure/flow studies. Pressure/flow studies were also performed after 3 months.
  
  
  RESULTS
  There was no statistical difference between groups in any of the preoperative parameters. All patients were considered urodynamically obstructed at preoperative pressure studies. As for catheter days and hospitalization days, statistical differences between TVP and TURP were found; catheter days were 2.71 days (SE 0.12) in the TURP group vs. 1.9 (SE 0.24) in the TVP group (p < 0.000). Hospitalization was 4.7 days (SE 0.22) after TURP and 3.9 days (SE 0.24) after TVP (p < 0.000). Mean preoperative I-PSS score was 18.84 and 18.19 in the TVP and TURP groups, respectively. At 3, 6 and 12 months, IPSS was 5.52 and 5.50, 3.77 and 4.94, 3.52 and 4.04 for TURP and TVP, respectively. Mean preoperative peak flow rate (PFR) was 8.78 and 7.26 ml/s for TURP and TVP, respectively; after 3, 6 and 12 months, PFR was 19.21 and 18.8, 20.77 and 20.13, 20.30 and 20.31 ml/s, respectively. After 3 months, 6 patients in the TURP group (7.5%) and 7 patients in the TVP group (10%) were borderline obstructed. 1 patient in the TVP group (1.4%) was still obstructed and underwent TURP. As for complications, 4 patients (5.7%) in the TVP group had stress urinary incontinence after 12 months vs. 1 (1.25%) in the TURP group.
  
  
  CONCLUSIONS
  The present study clearly demonstrates that TVP is as effective as TURP in relieving urinary obstruction due to BPH, it offers some advantages in terms of catheterization and hospital stay, but at the price of a higher incidence of postoperative urine incontinence. Technical improvements might solve this problem in the future, perhaps combining TVP with TURP of the apical tissue.
authors.affiliation: A.Ur.O. Cooperative Group Associazione Urologi Ospedalieri, Pietra Ligure, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gallucci
authors.forename: P
authors.initials: P
authors.lastname: Puppo
authors.forename: M
authors.initials: M
authors.lastname: Perachino
authors.forename: P
authors.initials: P
authors.lastname: Fortunato
authors.forename: G
authors.initials: G
authors.lastname: Muto
authors.forename: G
authors.initials: G
authors.lastname: Breda
authors.forename: A
authors.initials: A
authors.lastname: Mandressi
authors.forename: G
authors.initials: G
authors.lastname: Comeri
authors.forename: C
authors.initials: C
authors.lastname: Boccafoschi
authors.forename: F
authors.initials: F
authors.lastname: Francesca
authors.forename: S
authors.initials: S
authors.lastname: Guazzieri
authors.forename: G L
authors.initials: GL
authors.lastname: Pappagallo
mesh_terms: D000368:Aged; D004598:Electrosurgery / Q000009:adverse effects / Q000379:methods*; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011468:Prostatectomy / Q000009:adverse effects / Q000379:methods*; D011470:Prostatic Hyperplasia / Q000601:surgery*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology; D016896:Treatment Outcome; D014521:Urethra; D014549:Urinary Incontinence / Q000453:epidemiology / Q000209:etiology; D014563:Urodynamics
chemical_list: D006454:Hemoglobins