title: An expert system for assigning patients into clinical trials based on Bayesian networks.
abstract: Assigning patients into clinical trials is a knowledge and data intensive task. Eligibility determination for entry into a clinical trial is based upon specific inclusion and exclusion criteria. This paper investigates the use of an excerpt system to assist the physician through this task. This expert system uses Bayesian networks, a probabilistic method that can take advantage of pre-existing statistical knowledge. The paper also describes the feasibility of such a system by presenting the implementation of three clinical protocols. The experimental results reveal that the approach is feasible. The system gives correct eligibility scores when all evidence is available but also predicts eligibility when there is missing evidence. The system directs the physician to the protocols the patient is most eligible for, according to the current evidence. The system has the ability of learning its prior and conditional probabilities (expert knowledge) from training examples.
authors.affiliation: H. Lee Moffitt Cancer Center & Research Institute, University of South Florida, Tampa 33612, USA.
authors.forename: C
authors.initials: C
authors.lastname: Papaconstantinou
authors.forename: G
authors.initials: G
authors.lastname: Theocharous
authors.forename: S
authors.initials: S
authors.lastname: Mahadevan
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001499:Bayes Theorem; D001943:Breast Neoplasms / Q000628:therapy; D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D003195:Computer Communication Networks; D005103:Expert Systems; D005240:Feasibility Studies; D005260:Female; D005544:Forecasting; D006801:Humans; D018579:Patient Selection; D011336:Probability