title: Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms.
authors.affiliation: Departments of Anesthesiology and Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
authors.forename: D K
authors.initials: DK
authors.lastname: Spracklin
authors.forename: E D
authors.initials: ED
authors.lastname: Kharasch
mesh_terms: D018685:Anesthetics, Inhalation / Q000378:metabolism*; D001189:Aryl Hydrocarbon Hydroxylases; D065637:Cytochrome P-450 CYP2A6; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D006221:Halothane / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000502:physiology*; D008168:Lung / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000502:physiology*; D010084:Oxidation-Reduction
chemical_list: D018685:Anesthetics, Inhalation; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C104464:CYP3A protein, human; D065637:Cytochrome P-450 CYP2A6; D051544:Cytochrome P-450 CYP3A; D006221:Halothane