title: An efficient and convenient procedure for the synthesis of N(alpha)-Fmoc-O-monobenzyl phosphonotyrosine.
abstract: An efficient procedure is described for the synthesis of N(alpha)-Fmoc-O-monobenzyl phosphonotyrosine from the corresponding dibenzyl derivative by monodebenzylation in the presence of sodium iodide. A simple work up procedure removes the by-products and the monobenzylated phosphono product is obtained in high yield.
authors.affiliation: Physical Methods Department, Roche Discovery Welwyn, Welwyn Garden City, Hertfordshire, UK.
authors.forename: B K
authors.initials: BK
authors.lastname: Handa
authors.forename: C J
authors.initials: CJ
authors.lastname: Hobbs
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001593:Benzyl Compounds / Q000138:chemical synthesis*; D005449:Fluorenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010455:Peptides / Q000138:chemical synthesis*; D019000:Phosphotyrosine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001593:Benzyl Compounds; D005449:Fluorenes; C113500:N(alpha)-fluorenylmethyloxycarbonyl-monobenzyl phosphonotyrosine; D010455:Peptides; D019000:Phosphotyrosine