Effects of prenatal maternal TRH stimulation on the postnatal ability of neonatal piglets to cope with a cold challenge.
The effect of administering thyrotropin-releasing hormone (TRH) before farrowing on the ability of their newborn piglets to withstand a cold challenge was studied. Sows received intravenous infusions of TRH (5 microg kg(-1); TRH group) or physiological saline (0.9% NaCl; control group) from day 105 of gestation until farrowing. The plasma concentrations of thyroxine and triiodothyronine increased in sows treated with TRH. There were no differences in thyroxine and triiodothyronine between pigs born to sows in the TRH group and those of the control group. The rectal temperature of piglets born to TRH-treated sows decreased less than that of piglets born to controls as a consequence of a 1-hour cold challenge. Piglets born to sows in the TRH group had higher body weights at birth, and by day 28 they were an average 600 g heavier than those born to sows in the control group. Summarizing, prenatal maternal treatment with TRH appears to increase piglets' resistance to cold as well as to have beneficial effects on birth and weaning weights.
Finsten
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Department of Anatomy and Physiology, University of Prince Edward Island, Charlottetown, Canada.
Donald
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Bate
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D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology*; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D003080:Cold Temperature / Q000009:adverse effects*; D005260:Female; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013552:Swine; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine