title: [Polymerase chain reaction in diagnosing cytomegalovirus infection in HIV-infected patients].
abstract: The authors propose a simple and standard approach to semi-quantitative detection of cytomegalovirus (CMV) DNA in blood leukocytes by the polymerase chain reaction. The method was used in early diagnosis and treatment of manifest CMV infection in HIV-infected patients. High titers of CMV DNA correlated with the manifestation of CMV disease and progressive loss of host immune function. Clinical significance of difference in DNA titers was revealed. The proposed method can be used to assess the efficacy of specific anti-CMV therapy.
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Shipulina
authors.forename: V I
authors.initials: VI
authors.lastname: Shakhgil'dian
authors.forename: G A
authors.initials: GA
authors.lastname: Shipulin
authors.forename: A V
authors.initials: AV
authors.lastname: Kravchenko
authors.forename: L V
authors.initials: LV
authors.lastname: Serebrovskaia
authors.forename: V V
authors.initials: VV
authors.lastname: Pokrovskiĭ
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001483:Base Sequence; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D017931:DNA Primers; D004279:DNA, Viral / Q000097:blood; D017245:Foscarnet / Q000627:therapeutic use; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction
chemical_list: D000998:Antiviral Agents; D017931:DNA Primers; D004279:DNA, Viral; D017245:Foscarnet; D015774:Ganciclovir
vernacular_title: Polimeraznaia tsepnaia reaktsiia v diagnostike tsitomegalovirusnoĭ infektsii u VICh-infitsirovannykh patsientov.