Is halofantrine still advisable in malaria attacks?
Halofantrine is an antimalarial drug which is widely prescribed for the treatment of infections with chloroquine-resistant strains of Plasmodium falciparum. Chemically, it is a phenanthrene methanol, belonging to the aryl-amino-alcohol family. It has recently been recognized that this drug may induce rare but serious, cardiotoxic effects, including lengthening of the QTc interval, 'torsade de pointes' and induction of late ventricular potentials. These events are thought to be related to a quinidine-like action of the drug. In addition, severe haemolytic accidents have been reported, mimicking blackwater fever and indicating an immunological process. As a result of these side-effects, new guidelines for prescription and more cautious use of halofantrine, particularly as a stand-by treatment for febrile access among travellers, are required.
Touze
J E
JE
Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France. IMTSSA@gulliver.fr
Fourcade
L
L
Peyron
F
F
Heno
P
P
Deharo
J C
JC
D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D004562:Electrocardiography; D006331:Heart Diseases / Q000139:chemically induced / Q000503:physiopathology; D006461:Hemolysis; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010616:Phenanthrenes / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D011446:Prospective Studies
D000962:Antimalarials; D010616:Phenanthrenes; C023768:halofantrine