Autoradiographic localisation of substance P (NK1) receptors in human primary visual cortex.
This study utilised autoradiography to examine [125I]-Bolton Hunter substance P (BHSP) binding in postmortem human visual cortex. In the primary visual area, layers I-III, IVC and VI exhibited low levels of BHSP binding, while high levels were observed in layers IVB and V. Because cells in layers IVB and V are known to be involved in processing direction-specific stimuli, it is possible that SP plays a role in modulating this visual process.
Kus
L
L
School of Psychology, The University of New South Wales, Sydney 2052, Australia. l.kus@unsw.edu.au
Mazzone
S B
SB
Paxinos
G
G
Geraghty
D P
DP
D000328:Adult; D000368:Aged; D001345:Autoradiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D018040:Receptors, Neurokinin-1 / Q000032:analysis*; D014793:Visual Cortex / Q000737:chemistry*
D018040:Receptors, Neurokinin-1