title: A model of perinatal hypoxic-ischemic brain damage.
abstract: In conclusion, our immature rat model has gained wide acceptance as the animal model of choice to study basic physiologic, biochemical, and molecular mechanisms of perinatal hypoxic-ischemic brain damage. In addition, the model has been used extensively to study those physiologic and therapeutic variables which either are deleterious or beneficial to the perinatal brain undergoing hypoxia-ischemia. As therapeutic interventions are tested in the animal setting, the results will provide important information regarding the effect of these agents in the human setting.
authors.affiliation: Department of Pediatrics (Pediatric Neurology), Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033-0850, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Vannucci
authors.forename: S J
authors.initials: SJ
authors.lastname: Vannucci
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001237:Asphyxia / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D002534:Hypoxia, Brain / Q000503:physiopathology*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000503:physiopathology*; D051381:Rats