title: Preliminary investigation of the association of oral lichen planus and hepatitis C.
abstract: OBJECTIVE
  The aim of this investigation was to determine if an association exists between hepatitis C virus and oral lichen planus.
  
  
  METHODS
  Three groups of subjects were selected: 505 patients with hepatitis C virus infection (group 1), 100 patients with oral lichen planus (group 2), and a randomly selected control group (age- and gender-matched) of 100 healthy subjects (group 3). The prevalence of oral lichen planus was determined in groups 1 and 3, and the prevalence of hepatitis C virus infection was established in groups 2 and 3.
  
  
  RESULTS
  The prevalence of oral lichen planus was 3.36% (n = 17) in group 1 and 1% (n = 1) in the control group; the prevalence of hepatitis C virus infection was 23% (n = 23) in group 2, and 5% (n = 5) in the control group. No significant differences were observed in the incidence of oral lichen planus in group 1 between those patients who received interferon and those who did not. The 17 patients in group 1 who manifested oral lichen planus and hepatitis C virus infection simultaneously exhibited a marked tendency to have only reticular lesions (70.6%), with involvement of the buccal mucosa in 88.2% of these patients, the tongue in 29.4%, and the gingiva in 11.8%. Analyzing a randomized subgroup of 143 patients from group 1 (subgroup 1) that was matched by age and gender with groups 2 and 3, we found that the incidence of oral lichen planus in patients with hepatitis C virus infection (subgroup 1) was greater than in the control group (5.59% vs 1%), though this was not statistically significant (chi2 = 0.119; p = 0.06). In contrast, group 2 exhibited a statistically significant higher incidence of hepatitis C virus infection (23%) than the controls (5%; chi2 = 0.259, p = 0.0002).
  
  
  CONCLUSIONS
  The prevalence of hepatitis C virus infection in patients with oral lichen planus was greater than in the control series. In our opinion this observation warrants the investigation of potential concomitant hepatitis C virus infection in patients with oral lichen planus.
authors.affiliation: Department of Stomatology, Valencia University General Hospital, Spain.
authors.forename: J V
authors.initials: JV
authors.lastname: Bagán
authors.forename: C
authors.initials: C
authors.lastname: Ramón
authors.forename: L
authors.initials: L
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Diago
authors.forename: M A
authors.initials: MA
authors.lastname: Milián
authors.forename: R
authors.initials: R
authors.lastname: Cors
authors.forename: E
authors.initials: E
authors.lastname: Lloria
authors.forename: F
authors.initials: F
authors.lastname: Cardona
authors.forename: Y
authors.initials: Y
authors.lastname: Jiménez
mesh_terms: D002180:Candidiasis, Oral / Q000150:complications; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005882:Gingival Diseases / Q000150:complications / Q000473:pathology; D006526:Hepatitis C / Q000150:complications* / Q000628:therapy; D006801:Humans; D015994:Incidence; D007372:Interferons / Q000627:therapeutic use; D007972:Leukoplakia, Oral / Q000150:complications; D017676:Lichen Planus, Oral / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D015995:Prevalence; D013281:Stomatitis, Aphthous / Q000150:complications; D014060:Tongue Diseases / Q000150:complications / Q000473:pathology
chemical_list: D007372:Interferons