title: Young low responders protected from untoward effects of reduced ovarian response.
abstract: OBJECTIVE
  To correlate fertilization and clinical pregnancy rates (PRs) in low responders with their E2 levels (<500, 500-800, >800-1,000 pg/mL), age (20-30, 31-40, >40 years), number of follicles, and number of oocytes retrieved.
  
  
  METHODS
  A retrospective study.
  
  
  METHODS
  The IVF unit of an academic hospital.
  
  
  METHODS
  One hundred forty-three women who failed to attain E2 levels of 1,000 pg/mL on the day of hCG administration.
  
  
  METHODS
  Controlled ovarian hyperstimulation, blood E2 and progesterone measurements, ultrasonographic scanning of ovarian follicles, oocyte retrieval after hCG administration, and ET.
  
  
  METHODS
  Clinical PR.
  
  
  RESULTS
  Although E2 levels, fertilization rates, age, and number of oocytes did not differ significantly between the three age groups, the PR achieved in the youngest group was approximately three times as high (19.3%) as that achieved in the two older groups.
  
  
  CONCLUSIONS
  Young low responders represent a unique subset in that their age protects them from the deleterious effects of poor ovarian response.
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel. HANOCH@HADASSAH.ORG.IL
authors.forename: J
authors.initials: J
authors.lastname: Hanoch
authors.forename: Y
authors.initials: Y
authors.lastname: Lavy
authors.forename: H
authors.initials: H
authors.lastname: Holzer
authors.forename: A
authors.initials: A
authors.lastname: Hurwitz
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: A
authors.initials: A
authors.lastname: Revel
authors.forename: N
authors.initials: N
authors.lastname: Laufer
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D010053:Ovary / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D017211:Treatment Failure
chemical_list: D004958:Estradiol