title: Combined modality treatment of locally advanced lung cancer.
abstract: This paper describes the mechanisms of action of ionizing radiations combined with antineoplastic drugs. Some relevant drugs for the combined modality treatments of locally advanced lung cancer are reported. The meta-analyses including randomized trials comparing single agent (radiotherapy or chemotherapy) versus combined chemotherapy and radiotherapy in patients with unresectable non small cell lung cancer and limited small cell lung cancer are then reviewed. The clinical outcome in relation to different schedules of chemoradiotherapy (sequential, alternating and concurrent) is also focussed.
authors.affiliation: Department of Radiation Oncology, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy. rt.cro@ets.it
authors.forename: M G
authors.initials: MG
authors.lastname: Trovò
authors.forename: M
authors.initials: M
authors.lastname: Gigante
authors.forename: E
authors.initials: E
authors.lastname: Minatel
authors.forename: C
authors.initials: C
authors.lastname: Gobitti
authors.forename: G
authors.initials: G
authors.lastname: Franchin
mesh_terms: D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis; D016896:Treatment Outcome