title: Synthesis and antimicrobial activity of pyridines bearing thiazoline and thiazolidinone moieties.
abstract: Two series of new pyridines bearing thiazoline (3a--n) and thiazolidinone (5a--e) moieties were prepared via the cyclization of the corresponding substituted pyridyl thiourea (2a--g) with an appropriately substituted phenacyl bromide or chloroacetic acid, respectively. The antimicrobial activity was determined for representative compounds and most of them showed moderate activity against Gram-positive bacteria.
authors.affiliation: Pharmaceutical Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Egypt.
authors.forename: H Y
authors.initials: HY
authors.lastname: Hassan
authors.forename: N A
authors.initials: NA
authors.lastname: el-Koussi
authors.forename: Z S
authors.initials: ZS
authors.lastname: Farghaly
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011725:Pyridines; D013844:Thiazoles