[The role of sphingomyelin cycle products in development of apoptosis mediated by Fas receptors and tumor necrosis factor alpha].
Programmed cell death or apoptosis is a cell suicide developing according to a specific program, in which the sphingomyelin cycle products, ceramide and sphingosine, play the central role. The present review provides published data and the authors' results suggesting that the content of ceramide and sphingosine in the cell is controlled by the tumor necrosis factor alpha and activators of Fas receptor. The results of many experiments confirmed that the sphingomyelin cycle products induce cells death by the apoptotic pathway and enhance induced apoptosis. Ceramide and sphingosine regulate the activity of enzymes involved in transduction of apoptosis signal (protein kinases. Phosphatases, and proteases) and act as second messengers in transduction of the apoptosis signal.
Alesenko
A V
AV
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
Solov'ev
A S
AS
Terent'ev
A A
AA
Khrenov
A V
AV
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D002518:Ceramides / Q000502:physiology; D004789:Enzyme Activation; D053222:Fas Ligand Protein; D006801:Humans; D008562:Membrane Glycoproteins / Q000819:agonists / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013109:Sphingomyelins / Q000378:metabolism / Q000502:physiology*; D013110:Sphingosine / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000502:physiology*
D002518:Ceramides; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D018124:Receptors, Tumor Necrosis Factor; D013109:Sphingomyelins; D014409:Tumor Necrosis Factor-alpha; D013110:Sphingosine
Rol' produktov sfingomielinovogo tsikla v razvitii apoptoza, indutsirovannogo cherez retseptory Fas, i faktora nekrosa opukholi al'fa.