Synthesis and analgesic properties of new 5-thioaryl pyrazole derivatives.
A new series 5-thio aryl pyrazole derivatives were proposed aiming analgesic activity. In this work, 8 new compounds of this class were synthesized using usual synthetic methodology, having as key intermediate the 3-methyl-4-nitro-5-chloropyrazole-1-phenyl derivative and subsequent reaction with several nucleophiles sulfides. Pharmacological evaluation of this series showed analgesic activity in the some extent in especially for 5-(4-bromophenyl)-thio-3-methyl-4-nitro-1-phenylpyrazole which was the most potent in this series, presenting an analgesic action comparable to that show by dipyrone.
Pereira
N P
NP
Programa de Pós-Graduação em Química Orgânica, Universidade Federal do Rio de Janeiro, Brazil.
Monteiro
T M
TM
Freitas
A C
AC
Barreiro
E J
EJ
Miranda
A L
AL
D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D018712:Analgesics, Non-Narcotic; D011720:Pyrazoles