Positive result by serology indicates active Helicobacter pylori infection in patients with atrophic gastritis.
Patients with atrophic corpus gastritis and elevated Helicobacter pylori antibody titers but 13C-urea breath test (13C-UBT) and histology results negative for H. pylori were randomized into eradication therapy or follow-up only. Antibody levels decreased significantly in six out of seven patients in the eradication group, while in the follow-up group, the titers declined in only one out of eight patients. In patients with atrophic corpus gastritis, positive serology results may indicate an ongoing infection in spite of negative 13C-UBT and histology results.
Kokkola
A
A
Second Department of Surgery, Helsinki University Central Hospital, Finland.
Rautelin
H
H
Puolakkainen
P
P
Sipponen
P
P
Färkkilä
M
M
Haapiainen
R
R
Kosunen
T U
TU
D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood*; D001944:Breath Tests; D004359:Drug Therapy, Combination; D005757:Gastritis, Atrophic / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D014508:Urea / Q000032:analysis
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D000658:Amoxicillin; D014508:Urea