[Comparative study of antiradical effects of several antiglaucoma drugs].
Studies of the in vitro inhibitory effects of drugs most often used in the treatment of primary glaucoma on the generation of the main active oxygen forms (hydroxyl radical, superoxide anion radical, singlet oxygen and radical products of hydrogen peroxide and peroxidase reaction) showed that antiradical activity is more intrinsic for thimolol and decreases in the following series: betoptic-pilocarpinclofelin. This once more validates the efficacy of beta-blockers in the treatment of glaucoma and prevention of cataract associated with it.
Kurysheva
N I
NI
Deeva
I B
IB
Deev
A I
AI
Erichev
V P
VP
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D015784:Betaxolol / Q000494:pharmacology; D002386:Cataract / Q000517:prevention & control; D003000:Clonidine / Q000494:pharmacology; D005609:Free Radicals / Q000037:antagonists & inhibitors*; D005901:Glaucoma / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors; D008163:Luminescent Measurements; D008916:Miotics / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology; D010544:Peroxidases / Q000378:metabolism; D010862:Pilocarpine / Q000494:pharmacology; D017382:Reactive Oxygen Species; D013481:Superoxides / Q000378:metabolism; D013565:Sympatholytics / Q000494:pharmacology; D013999:Timolol / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D005609:Free Radicals; D008916:Miotics; D010277:Parasympathomimetics; D017382:Reactive Oxygen Species; D013565:Sympatholytics; D010862:Pilocarpine; D013481:Superoxides; D017665:Hydroxyl Radical; D013999:Timolol; D006861:Hydrogen Peroxide; D010544:Peroxidases; D003000:Clonidine; D015784:Betaxolol
Sravnitel'noe izuchenie antiradikal'nogo deĭstviia nekotorykh antiglaukomatoznykh preparatov.