Study of local anaesthetics. Part 139. Preformulation study of N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl] dimethylammonium chloride.
In the course of the drug form development of substance XIX B (N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl] dimethylammonium chloride [1]) the influence of auxiliary substance, namely glycerol (GL), propylene glycol (PG) and sorbitol (SO), used in the form of 5, 10, 15 and 20% solution, on the surface tension, partition coefficient, viscosity and liberation from aqueous solutions was studied. These parameters can influence the bioavailability. The obtained results show that as an optimal additive 5% SO may be used since this ensured maximal amount of liberated substance XIX B.
Vitková
Z
Z
Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic.
Gardavská
K
K
Cizmárik
J
J
D000779:Anesthetics, Local / Q000737:chemistry* / Q000493:pharmacokinetics; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D005990:Glycerol; D010880:Piperidines / Q000737:chemistry* / Q000493:pharmacokinetics; D019946:Propylene Glycol; D012996:Solutions; D013012:Sorbitol; D013500:Surface Tension; D014783:Viscosity
D000779:Anesthetics, Local; D010880:Piperidines; D012996:Solutions; D013012:Sorbitol; C013549:heptacaine; D019946:Propylene Glycol; D005990:Glycerol