Role of Crk oncogene product in physiologic signaling.
v-Crk is a member of the family of adaptor-type signaling molecules that consist mostly of SH2 and SH3 domains. The cellular homologs of v-Crk includes CrkI, CrkII, and CrkL; these have been isolated from species ranging from lower vertebrates to man. Crk-family proteins are involved in a variety of signaling cascades such as those of growth factor receptor, integrin, T-cell receptor, B-cell antigen receptor, and cytokines. It has been postulated that the primary function of Crk is to recruit cytoplasmic proteins in the vicinity of tyrosine kinases through SH2-phosphotyrosine interaction. Thus, the output from Crk depends on the SH3-binding proteins, which include the C3G guanine nucleotide exchange protein for Rap1, Abl tyrosine kinase, DOCK180, and the Sos guanine nucleotide exchange protein for Ras. The variety of the Crk-binding proteins indicate the pleiotropic function of Crk.
Kiyokawa
E
E
Department of Pathology, National Institute of Infectious Diseases, International Medical Center of Japan, Tokyo.
Mochizuki
N
N
Kurata
T
T
Matsuda
M
M
D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000502:physiology; D008956:Models, Chemical; D050736:Oncogene Protein v-crk; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology; D015682:Retroviridae Proteins, Oncogenic / Q000502:physiology*; D015398:Signal Transduction; D014714:Vertebrates; D018909:src Homology Domains
D016023:Integrins; D050736:Oncogene Protein v-crk; D011956:Receptors, Cell Surface; D015682:Retroviridae Proteins, Oncogenic; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases