Immunoisolation of adult porcine islets for the treatment of diabetes mellitus. The use of photopolymerizable polyethylene glycol in the conformal coating of mass-isolated porcine islets.
Functional porcine islets, free of known pathogens, can serve as a source of insulin producing cells for the treatment of experimentally induced insulin dependent Diabetes Mellitus. Porcine islets can be conformally coated (microencapsulated) with a covalently linked, stable permselective membrane while maintaining islet viability and function. The PEG conformal coating is immunoprotective in a discordant xenograft animal model (porcine islets to rat).
Hill
R S
RS
Neocrin Company, Irvine, California 92718, USA. rshill@neocrin.com
Cruise
G M
GM
Hager
S R
SR
Lamberti
F V
FV
Yu
X
X
Garufis
C L
CL
Yu
Y
Y
Mundwiler
K E
KE
Cole
J F
JF
Hubbell
J A
JA
Hegre
O D
OD
Scharp
D W
DW
D000818:Animals; D001672:Biocompatible Materials; D002214:Capsules; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D016381:Islets of Langerhans Transplantation / Q000276:immunology / Q000379:methods*; D008567:Membranes, Artificial; D019397:Pancreas, Artificial; D010777:Photochemistry; D011092:Polyethylene Glycols; D051381:Rats; D013552:Swine; D014181:Transplantation Immunology
D001672:Biocompatible Materials; D002214:Capsules; D008567:Membranes, Artificial; D011092:Polyethylene Glycols