[Toxic epidermal necrolysis after the use of intermediate dose of cytosine arabinoside].
Toxic epidermal necrolysis is a drug-induced dermatologic disease related to Lyell syndrome, erythema multiforme and Stevens-Johnson syndrome.


OBJECTIVE
To report a fatal case of toxic epidermal necrolysis owing to intermediate dose of cytarabine.


METHODS
A 16 year-old female patient with acute lymphocytic leukemia (LLA-L1) treated with the Protocol of the Brazilian Group for Treatment of Leukemia of Childwood (GBTLI-85-AR). On the second day after the administration of intermediate dose of cytarabine (1.5 g/m2 i.v. every 12 hours for 3 days), she presented bullous lesions in the left buttock that disseminated envolving to necrosis, sepsis, and death on the 13th day.


CONCLUSIONS
Cytarabine is frequently associated with dermatologic toxicity but, until now, there is no other case of toxic epidermal necrolysis described.
Figueiredo
M S
MS
Departamento de Medicina, Universidade Federal de São Paulo-Escola Paulista de Medicina.
Yamamoto
M
M
Kerbauy
J
J
D000293:Adolescent; D003561:Cytarabine / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D013262:Stevens-Johnson Syndrome
D003561:Cytarabine
Necrólise epidérmica tóxica secundária ao uso da citosina-arabinosídeo em dose intermediária.