Mild cognitive impairment and risk of mortality in HIV-1 infection.
HIV-1-associated cognitive impairment has only been preliminarily investigated for associations with mortality. The authors examined 119 HIV-1-positive homosexual men (asymptomatic: n = 96; early symptomatic: n = 23). At follow-up (to 3.5 years), there were 105 survivors and 14 nonsurvivors. Those at the 25th percentile in response speeds and in long-term memory retrieval accuracy were at 6.4 (P < 0.02) and 3.5 (P < 0.05) times increased mortality risk, respectively, of those at the 75th percentile--independent of baseline CDC clinical stage, CD4 cell count, hemoglobin level, antiretroviral and prophylactic medication use, and sociodemographics. Cognitive impairment should be identified early--for maximization of both functional status and survival time.
Wilkie
F L
FL
Department of Psychiatry, University of Miami School of Medicine, Florida 33136, USA.
Goodkin
K
K
Eisdorfer
C
C
Feaster
D
D
Morgan
R
R
Fletcher
M A
MA
Blaney
N
N
Baum
M
M
Szapocznik
J
J
D015526:AIDS Dementia Complex / Q000401:mortality*; D000328:Adult; D018450:Disease Progression; D005431:Florida / Q000453:epidemiology; D005500:Follow-Up Studies; D015497:HIV-1; D018451:Homosexuality, Male / Q000706:statistics & numerical data; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008569:Memory Disorders / Q000453:epidemiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D016017:Odds Ratio; D011379:Prognosis; D016016:Proportional Hazards Models; D011930:Reaction Time; D012307:Risk Factors