PDGF and TGF-beta induce cell shape changes in invertebrate immunocytes via specific cell surface receptors.
The presence of PDGF receptor-alpha- and -beta- and TGF-beta-receptor (type II)-like molecules on the plasma membranes of the immunocytes of the mollusc Mytilus galloprovincialis was demonstrated by an immunocytochemical procedure. Furthermore, the present study provides evidence that PDGF-AB and TGF-beta1 provoke cell shape changes in immunocytes via interactions with the respective receptors and that these extracellular signals are transduced along the phosphoinositide signaling pathway.
Kletsas
D
D
Institute of Biology, National Center for Scientific Research Demokritos, Athens, Greece.
Sassi
D
D
Franchini
A
A
Ottaviani
E
E
D000818:Animals; D049872:Bivalvia; D048429:Cell Size / Q000187:drug effects; D006434:Hemocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D010982:Platelet-Derived Growth Factor / Q000502:physiology*; D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta; D017479:Receptors, Platelet-Derived Growth Factor / Q000502:physiology*; D018125:Receptors, Transforming Growth Factor beta / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology; D016212:Transforming Growth Factor beta / Q000502:physiology*
D010982:Platelet-Derived Growth Factor; D018125:Receptors, Transforming Growth Factor beta; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C095477:platelet-derived growth factor AB; D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta; D017479:Receptors, Platelet-Derived Growth Factor