[The effect of the immunostimulating agent trimezon on the cells of the mononuclear phagocytosing system].
The effect of the immunostimulator trimeson of the 8-aza-gomogonan series on the cells of the mononuclear monocyte system was studied in C3H and ICR mice in vitro. Intraperitoneal injection of trimeson (50 mg/kg 1 x 10(-7)-1 x 10(6) M) inhibits, as a rule, the initial stages of the phagocytizing process but stimulates the bactericidal properties of the peritoneal phagocytes and their mechanisms of processing and destruction of the antigen material. In the system of adaptive transfer of donor splenocytes and peritoneal macrophages to recipients exposed to lethal radiation, trimeson (20 mg/kg intravenously, 50 mg/kg per os) increases the immunogenic function of the mononuclear phagocytes in formation of the primary immune response to sheep erythrocytes.
Liubin
G S
GS
Department of Biological Experiments, Byelorussian Academy of Sciences, Minsk, Byelorussia.
Konoplia
N A
NA
Golubeva
M B
MB
Maskovich
A E
AE
Kuz'mitskiĭ
B B
BB
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D019264:Adoptive Transfer; D000704:Analysis of Variance; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D001372:Aza Compounds / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects / Q000528:radiation effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D010587:Phagocytosis / Q000187:drug effects*; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D001372:Aza Compounds; C087739:trimezon
Vliianie immunostimuliruiushchego agenta trimezona na kletki mononuklearnoĭ fagotsitiruiushcheĭ sistemy.