Effects of risperidone and SCH 23390 on isolation-induced aggression in male mice.
In this study, the antiaggressive effects of risperidone and SCH 23390 have been explored. Using the paradigm of isolation-induced aggression, 150 albino male mice of the OF1 strain were allocated to control and experimental groups which received three doses of risperidone (0.01, 0.05 and 0.1 mg/kg) or two doses of SCH 23390 (0.05 and 0.1 mg/kg). Only the highest doses of risperidone decreased threat and attack behaviours but all doses significantly impaired motor behaviour. SCH 23390 decreased attack with the two doses used and also produced significant increases in immobility. Although both antipsychotics are antiaggressive, this action seems to be more specific in the case of risperidone. Finally, both drugs failed to affect animals with short attack latency, being antiaggressive only in subjects with long attack latency, which suggests that these two types of animals are different in their dopamine and serotonin neurotransmission.
Rodríguez-Arias
M
M
Area de Psicobiología, Facultad de Psicología, Universitat de València, Spain. Marta.Rodriguez@uv.es
Miñarro
J
J
Aguilar
M A
MA
Pinazo
J
J
Simón
V M
VM
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D003864:Depression, Chemical; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D006120:Grooming; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors; D018967:Risperidone / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D012934:Social Isolation
D001552:Benzazepines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D018967:Risperidone