title: Sotalol associated torsades de pointes tachycardia in a 15-month-old child: successful therapy with magnesium aspartate.
abstract: Torsades de points (Tdp) is a form of ventricular tachycardia, and its occurrence in childhood is very rare. In adult patients treated with sotalol, Tdp has been reported to the occur with an incidence of 2%-4%. In children who are treated with sotalol, occurrence of Tdp has been reported in only a single case. A 15-month-old girl with Wolff-Parkinson-White syndrome developed recurrent syncopal attacks. She had been treated with sotalol 1.5 mg/kg daily since shortly after birth because of recurrent episodes of paroxysmal supraventricular tachycardia. ECG monitoring exhibited frequent Tdp tachycardia. Serum electrolyte levels were normal. Echocardiographic analysis excluded a structural heart defect and did not show any signs of myocardial infection. Sotalol treatment was stopped and an infusion with lidocaine was started. Despite this therapy the Tdp continued. Magnesium aspartate was then administered, which immediately stopped the Tdp. As no other reason was evident, Tdp in this child has to be judged as a proarrhythmia related to sotalol therapy.
authors.affiliation: Department of Paediatrics III, Children's Hospital, University School of Medicine Hannover, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Sasse
authors.forename: T
authors.initials: T
authors.lastname: Paul
authors.forename: P
authors.initials: P
authors.lastname: Bergmann
authors.forename: H C
authors.initials: HC
authors.lastname: Kallfelz
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001224:Aspartic Acid / Q000627:therapeutic use*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D013015:Sotalol / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000188:drug therapy*; D014927:Wolff-Parkinson-White Syndrome / Q000188:drug therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D001224:Aspartic Acid; D013015:Sotalol