title: pO2 measurement in an experimental model of patellar tendon autograft pro-anterior cruciate ligament.
abstract: Thirty-four sheep were submitted to surgery substituting the native ACL with the central third of the patellar tendon, ten enter this study. The purpose was to find a possible relationship between tissue pO2 and healing processes considering also the biomechanical and histomorphological aspects of the grafts. Four of them were sacrificed under general anaesthesia after 6 months, and six after 1 year in order to perform tissue pO2 measurement and an analysis of microvessel density on specimens of the normal ACL and the graft. Our data showed higher pO2 values of the autografts after 6 months. After 1 year the data was comparable to those of native ACL. This was confirmed by a microvessel count of the histological specimens and the data was in relationship to biomechanical and histomorphological analysis. Tissue pO2 can be observed and recorded in "in vivo" ACL, and patellar tendon used as graft, with no injury to their integrity. The monitoring system might be considered as an experimental tool for indirect controls of the anterior cruciate substitutes.
authors.affiliation: Medical School, University of Bologna, Department of Experimental Surgery, Italy. giardino@alma.unibo.it
authors.forename: M
authors.initials: M
authors.lastname: Rocca
authors.forename: G
authors.initials: G
authors.lastname: Giavaresi
authors.forename: N
authors.initials: N
authors.lastname: Nicoli Aldini
authors.forename: M
authors.initials: M
authors.lastname: Fini
authors.forename: M
authors.initials: M
authors.lastname: Marcacci
authors.forename: S
authors.initials: S
authors.lastname: Zaffagnini
authors.forename: R
authors.initials: R
authors.lastname: Giardino
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D005260:Female; D007719:Knee Joint / Q000601:surgery*; D008023:Ligaments, Articular / Q000737:chemistry / Q000601:surgery*; D010100:Oxygen / Q000032:analysis*; D010101:Oxygen Consumption; D010313:Partial Pressure; D017847:Patellar Ligament / Q000601:surgery*; D012756:Sheep; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D010100:Oxygen