title: Large granular lymphocytic leukemia: an overview.
abstract: Large granular lymphocytes are killer cells that differentiate into natural killer and T-cell types. Neoplastic proliferation of the lineages probably involves different etiologies, producing leukemias with distinct clinical presentations and prognoses. T-large granular lymphocytic leukemia has prominent autoimmune features and may occur in association with other autoimmune diseases, particularly rheumatoid arthritis.
authors.affiliation: H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA.
authors.forename: T P
authors.initials: TP
authors.lastname: Loughran
mesh_terms: D017209:Apoptosis / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology*