[Cloning and characterization of CCRS receptors of chemokines, principal receptors of the AIDS virus].
Chemokine receptors belong to G protein-coupled receptors. The chemokine receptor CCR5, that binds M1P-1 alpha, M1P-1 beta and RANTES, was characterized as the main coreceptors for M-tropic strains of HIV-1, the most important for the transmission of the disease. This receptor is necessary, together with CD4, for the entry of the virus in its target cells. A mutant form of the receptor, frequent in European populations, confers to homozygotes a strong resistance to the virus, and to heterozygotes a relative resistance. We have determined by mutagenesis the regions of CCR5 that are important for its interaction with the viral envelope and with its natural ligands.
Parmentier
M
M
IRIBHN et Service de Génétique médicale, Campus Erasme de l'Université libre de Bruxelles.
D018925:Chemokines; D019976:Cloning, Organism; D015497:HIV-1; D006801:Humans; D011991:Receptors, Virus
D018925:Chemokines; D011991:Receptors, Virus
Clonage et caractérisation du récepteur CCR5 des chimiokines, principal corécepteur des virus de l'immunodéficience humaine.