[Determination of DNA content in salivary gland tumors].
BACKGROUND
DNA content determination is a useful tool in the characterization of different malignant tumors.


OBJECTIVE
To measure DNA content in cells of salivary gland tumors as adjunct to histological diagnosis, correlating morphologic and biological features of these tumors.


METHODS
From the archives of the Pathology service of a general hospital, 21 salivary gland tumors, 15 pleomorphic adenomas, 3 mucoepidermoid carcinomas and 3 cystic adenoid carcinomas were selected. DNA content was determined in the histological samples using a flow cytometric DNA analysis.


RESULTS
All pleomorphic adenomas had a normal or diploid DNA content. Fifty percent of malignant tumors had an aneuploid DNA content (1 mucoepidermoid carcinoma and 2 cystic adenoid carcinomas).


CONCLUSIONS
DNA determination may help in the histological diagnosis of salivary gland tumors. The presence of aneuploidy suggests malignity.
Yáñez
M
M
Unidad de Anatomía Patológica-Citopatología Hospital de Temuco, Chile.
Roa
I
I
Villaseca
M
M
Fuentealba
P
P
D008949:Adenoma, Pleomorphic / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D000782:Aneuploidy; D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D018277:Carcinoma, Mucoepidermoid / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm
Determinación del contenido de ADN en tumores de glándulas salivales.