title: The comparison of four weight reduction strategies aimed at overweight patients with diabetes mellitus: four-year follow-up.
abstract: Weight change and glycaemic control in 132 diabetic patients previously treated for 1 year by four different methods aimed at weight loss were reanalysed 4 years after the outset. The four treatment groups comprised clinic visits, home visits, behavioural group therapy, and dexfenfluramine given for the initial 3 months followed by clinic visits. When analysed on an intention to treat basis only the dexfenfluramine group maintained a significant weight loss at year 4 (mean -2.46 kg) with 43% of patients losing 3 kg or more; HBA1c was not decreased. The other treatment groups showed overall weight regain from year 1 to year 4. Within the home visit group however, the number of patients losing at least 3 kg doubled between years 1 (21%) and 4 (38%). When analysed on a completion basis, weight loss in the dexfenfluramine group was significant in females but not in males at year 4. During the 4 years of observation a cohort of 54 patients reflecting our routine clinic practice gained on average 0.35 kg. Although now withdrawn, the use of an appetite suppressant dexfenfluramine for just 3 months would appear to have a long-term advantage on weight loss in this diabetic population, although the weight lost was not associated with improvement in glycaemic control.
authors.affiliation: The Diabetes Centre, Ninewells Hospital and Medical School, Dundee, Scotland.
authors.forename: R M
authors.initials: RM
authors.lastname: Manning
authors.forename: R T
authors.initials: RT
authors.lastname: Jung
authors.forename: G P
authors.initials: GP
authors.lastname: Leese
authors.forename: R W
authors.initials: RW
authors.lastname: Newton
mesh_terms: D000553:Ambulatory Care; D001067:Appetite Depressants / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000628:therapy*; D004046:Dietetics; D005260:Female; D005277:Fenfluramine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006699:Home Care Services; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D011615:Psychotherapy, Group; D015431:Weight Loss
chemical_list: D001067:Appetite Depressants; D005277:Fenfluramine; D006442:Glycated Hemoglobin