Kinetics of aluminum disposition after ingestion of low to moderate pharmacological doses of aluminum.
We assessed the kinetics of aluminum uptake and elimination by tissues of Sprague Dawley rats following a single gavage dose of 0, 0.25, 0.5, or 1 mmol Al/kg body weight (b.w.) in 1 ml of 16% citrate (equivalent to 0-650 mg Al to a 70-kg human). Serum, liver, kidney, and tibia aluminum concentrations were measured 15, 30, 60, 120, 270, and 360 min after dosing. Serum aluminum concentrations were proportional to dose in rats dosed with 0.25 or 0.5 mmol Al/kg b.w. but were not proportional to dose for rats dosed with 1 mmol Al/kg b.w. Elimination half-lives of serum aluminum were similar for all treatments (102-119 min) which suggests that the non-linear aluminum kinetics in serum reflected a difference in absorption of the highest dose. Although fasted rats dosed with 0.25 or 1 mmol Al/kg b.w. with citrate absorbed aluminum with similar efficiency (4.2% of dose), the length of the absorptive period was prolonged in the rats given the highest does. Total absorbed aluminum mass in rats dosed with 0.25 and 0.5 mmol vs. 1 mmol Al/kg b.w. reached a plateau at 120 vs. 270 min after dosing, respectively. The kinetics of aluminum in liver, bone, and kidney were generally dose-independent. Elimination half-lives of liver aluminum were similar for all aluminum treatments (267-465 min); elimination half-lives could not be estimated in bone and kidney because of turnover exceeded the 6 h collection period.
Sutherland
J E
JE
Environmental Toxicology Center, University of Wisconsin-Madison, 53706, USA.
Greger
J L
JL
D017607:Aluminum Compounds / Q000493:pharmacokinetics*; D000818:Animals; D019540:Area Under Curve; D001646:Bile / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D006207:Half-Life; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D007773:Lactates / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D017607:Aluminum Compounds; D007773:Lactates; C104223:aluminum lactate