p53 molecule as a prognostic marker in human malignancies.
The tumor suppressor gene, p53, is the most commonly mutated gene associated with cancer. Mutation of p53 plays a critical role in the multiple stages of carcinogenesis. The functional inactivation of p53 by missense mutations has been described in various cancers and the majority of these mutations occur in exons 5 through 9 of the p53 gene. Mutations leading to the overexpression of p53 have been found to affect the patient survival outcome in several human malignancies. Our experience with more than 200 samples of breast and prostate carcinoma is presented. Our results strongly suggest that the type and location of the p53 mutations within the molecule may affect and dictate the outcome of cancer.
Munshi
A
A
Department of Surgery, LSUMC, New Orleans, USA.
Byrne
P
P
Ramesh
R
R
Freeman
S M
SM
Marrogi
A J
AJ
D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics*
D014408:Biomarkers, Tumor