title: Epidermoid cyst of the spleen with CA19-9 or carcinoembryonic antigen productions: report of three cases.
abstract: True splenic cyst is a relatively rare disease, and the majority of the cases are classified as epidermoid cysts. Three cases of epidermoid cysts in the spleen or accessory spleen were studied using an immunohistochemical technique and staining for mucin. In case 1, serum carcinoembryonic antigen (CEA) and CA19-9, and in cases 2 and 3, serum CA19-9, before surgery were markedly elevated, and these levels decreased postoperatively. This strongly indicates the relationship between the increase of tumor marker levels and the presence of the epidermoid cyst. In addition, stratified squamous epithelium in the resected tissues of cases 1 and 2 was positive for anti-CEA antibody and anti-CA19-9 antibody, and that of case 3 was positive for anti-CA19-9 antibody. This strongly supports CEA or CA19-9 production in the squamous epithelium.
authors.affiliation: First Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Higaki
authors.forename: A
authors.initials: A
authors.lastname: Jimi
authors.forename: J
authors.initials: J
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Kusaba
authors.forename: M
authors.initials: M
authors.lastname: Kojiro
mesh_terms: D000328:Adult; D000792:Angiography; D018395:CA-19-9 Antigen / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D004814:Epidermal Cyst / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D013158:Splenic Diseases / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen