title: Plasma homocysteine concentrations are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects.
abstract: An association between hyperhomocysteinemia and premature atherosclerosis in patients with non-insulin-dependent diabetes mellitus (NIDDM) has recently been described. Little is known about the role of insulin in homocysteine [H(e)] metabolism. We measured plasma H(e) concentrations in the fasting state and during a hyperinsulinemic-euglycemic clamp in normal subjects and patients with NIDDM. Plasma H(e) decreased significantly from 7.2 +/- 2.6 to 6.0 +/- 2.7 mmol/L (P < .01) in normal subjects, but did not change in patients with NIDDM (6.0 +/- 2.7 to 5.9 +/- 2.5 mmol/L, respectively). These data suggest that plasma H(e) concentrations are regulated by acute hyperinsulinemia in normal subjects, but not in insulin-resistant NIDDM subjects. These abnormalities may have implications for the pathogenesis of premature vascular disease associated with NIDDM.
authors.affiliation: Department of Medicine, University of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital, Little Rock 72205, USA.
authors.forename: V A
authors.initials: VA
authors.lastname: Fonseca
authors.forename: S
authors.initials: S
authors.lastname: Mudaliar
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
authors.forename: L M
authors.initials: LM
authors.lastname: Fink
authors.forename: P A
authors.initials: PA
authors.lastname: Kern
authors.forename: R R
authors.initials: RR
authors.lastname: Henry
mesh_terms: D000208:Acute Disease; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D015309:Glucose Clamp Technique; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values
chemical_list: D006710:Homocysteine