Enzymatic activation of prodrugs by prostate-specific antigen: targeted therapy for metastatic prostate cancer.
Denmeade
S R
SR
Johns Hopkins Oncology Center, Johns Hopkins School of Medicine, Baltimore, MD 21231-001, USA.
Isaacs
J T
JT
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis; D001711:Biotransformation; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011355:Prodrugs / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D011355:Prodrugs; D017430:Prostate-Specific Antigen