Correlation between serum cytokeratin 19 fragment and tissue polypeptide antigen levels in patients with non-malignant diseases.
It has been reported that cytokeratin 19 fragment (CYFRA 21-1) is superior to tissue polypeptide antigen (TPA) as a tumor marker, although there is a high correlation between CYFRA 21-1 and TPA levels in patients with lung cancer. We investigated correlations between these tumor markers in patients with non-malignant diseases. Marked correlations were found between CYFRA 21-1 and TPA levels in healthy subjects (n = 31), non-insulin-dependent diabetes mellitus (n = 160) and hemodialysis patients (n = 83) (range of r-value = 0.90-0.93, P < 0.0001). However in liver cirrhosis patients (n = 36), only a weak correlation was found (r = 0.39, P < 0.0001) and there were correlations between only TPA and both aspartate aminotransferase and alanine aminotransferase levels (r2 = 0.48 and 0.36, P < 0.0001). The elevated TPA levels in liver cirrhosis patients may be related to the decreased specificity of TPA as a tumor marker.
Kashiwabara
K
K
Fifth Department of Internal Medicine, Tokyo Medical College, Ibaraki, Japan.
Nakamura
H
H
Kiguchi
T
T
Matsuoka
T
T
D000410:Alanine Transaminase / Q000097:blood; D000951:Antigens, Neoplasm / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006801:Humans; D053539:Keratin-19; D007633:Keratins; D007676:Kidney Failure, Chronic / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood* / Q000201:enzymology; D006435:Renal Dialysis; D019396:Tissue Polypeptide Antigen / Q000097:blood*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053539:Keratin-19; D019396:Tissue Polypeptide Antigen; C102012:antigen CYFRA21.1; D007633:Keratins; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase