[Activities of glutathione enzymes in liver biopsy specimens in chronic lesions of hepatocytes].
The nonenzymatic conjugation of metabolites is decreased in chronic diseases of the liver, which is caused by decreased concentration of glutathione. The activities of glutathione enzymes are increased, this indicating the development of compensatory processes of mobilization of the second phase of detoxication, that is, increased conjugation under conditions of suppression of the cytochrome P-450 system. Measurement of liver glutathione transferase is a highly informative test for assessing the activity of the pathological process, particularly important in patients with chronic active hepatitis and cirrhosis of the liver.
Matiushin
B N
BN
Loginov
A S
AS
Tkachev
V D
VD
D001706:Biopsy; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000032:analysis* / Q000378:metabolism; D005980:Glutathione Reductase / Q000032:analysis* / Q000378:metabolism; D005982:Glutathione Transferase / Q000032:analysis* / Q000378:metabolism; D006521:Hepatitis, Chronic / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000201:enzymology / Q000378:metabolism; D008105:Liver Cirrhosis, Biliary / Q000201:enzymology / Q000378:metabolism; D008107:Liver Diseases / Q000201:enzymology* / Q000378:metabolism
D003577:Cytochrome P-450 Enzyme System; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione
Aktivnost' glutationzavisimykh fermentov v bioptate pecheni pri khronicheskom porazhenii gepatsitov.