Sensitization of the nervous system, induced by two successive hindpaw inflammations, is suppressed by a local anesthetic.
Two hindpaw injections of carrageenin were performed 7 days apart and the time-course of the vocalization thresholds to pressure (VTPP) of all the 4 paws of the rat were measured after both injections. The first injection of carrageenin induced an increase in the circumference of the injected paw and a significant reduction of the VTPPs of all the 4 paws. The pain-related behavior of both hindpaws was enhanced, when carrageenin was injected for the second time not only into the previously inflamed, but also into the contralateral hindpaw. However, the abnormal responses of the forepaws were not increased by this second hindpaw inflammation. Both after the first and the second injection of carrageenin, the decrease of the VTPPs of all 4 paws was antagonized by lidocaine with epinephrine (LE) injected into the inflamed paw. This anesthetic effect was of a shorter duration after the second than after the first injection of carrageenin. Presumably, the imprint that is left in the nervous system after the first hindpaw inflammation, takes place at a relatively limited segmental level. In addition, it is possible to influence the established sensitization of the nervous system by treating the peripheral process itself, even when the first injury has primed the nervous system to the second injury. However, there still seems to exist some excitatory influences that cannot be suppressed by the local anesthetic.
Kayser
V
V
Unité de Recherches de Physiopharmacologie du Système Nerveux, I.N. S.E.R.M. U-161, 2 rue d'Alésia, 75014 Paris, France. kayser@broca.inserm.fr
Idänpään-Heikkilä
J J
JJ
Guilbaud
G
G
D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced; D006614:Hindlimb / Q000294:innervation*; D007249:Inflammation / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D009437:Neuralgia / Q000139:chemically induced*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014828:Vocalization, Animal
D000779:Anesthetics, Local; D002351:Carrageenan; D008012:Lidocaine