title: Torsade de pointes with sotalol overdose treated successfully with lidocaine.
abstract: Torsade de pointes is a polymorphic ventricular tachyarrhythmia associated with a long QT interval. The prognosis is excellent if torsade is recognized early. In the acquired long QT syndrome, measures should be taken quickly to identify and correct all predisposing conditions and to treat or prevent torsade. Established treatments of acquired torsade are magnesium bolus, electrolyte replacement, isoproterenol infusion and cardiac pacing. Sotalol overdose causing torsade is reported in which lidocaine appears to have suppressed an episode of torsade as well as prevented further episodes. Current understanding of the electrophysiological mechanisms of torsade and lidocaine, a review of the literature and the author's experience indicate that lidocaine is a potentially useful therapy in torsade.
authors.affiliation: Royal Victoria Hospital, McGill University, Montreal, Quebec.
authors.forename: T L
authors.initials: TL
authors.lastname: Assimes
authors.forename: I
authors.initials: I
authors.lastname: Malcolm
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000506:poisoning*; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D062787:Drug Overdose; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D013015:Sotalol / Q000506:poisoning*; D016171:Torsades de Pointes / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D008012:Lidocaine; D013015:Sotalol