Successful treatment of ergotism with Iloprost--a case report.
A 34-year-old woman was hospitalized for severe acute arterial insufficiency of the limbs. Overuse of ergotamine derivative was acknowledged by the patient, who had a long history of migraine headaches. An arteriogram showed diffuse arterial spasm and occlusion of right leg distal arteries. Intravenous infusion of a stable prostacyclin analog (Iloprost) was administered. Rapid and complete improvement of arteriospasm was noted within a few hours, confirmed by a further arteriogram. This appears to be one of the rare case reports of successful limb salvage by use of Iloprost for ergotism.
Piquemal
R
R
Service de médecine interne B, hôpital Bretonneau, Tours, France.
Emmerich
J
J
Guilmot
J L
JL
Fiessinger
J N
JN
D000328:Adult; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004878:Ergotamine / Q000009:adverse effects / Q000627:therapeutic use; D004881:Ergotism / Q000150:complications*; D005260:Female; D006801:Humans; D016285:Iloprost / Q000627:therapeutic use*; D007866:Leg / Q000098:blood supply*; D008881:Migraine Disorders / Q000188:drug therapy; D014662:Vasoconstrictor Agents / Q000009:adverse effects / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D016285:Iloprost; D004878:Ergotamine