[Unusual coincidence of partially active endocrine tumors].
We report on a female patient who developed five different tumors between the age of 53 and 62 years. The following tumors were diagnosed, three of which showed endocrine activity: uterine myoma; hemangiopericytoma of the meninges; pleural mesothelioma; preperitoneal leiomyoma; medullary carcinoma of the thyroid (sporadic form) in a hyperthyroid goiter. Coexistence of hyperthyroidism and medullary carcinoma of the thyroid is rare. Paraneoplastically induced hypoglycemia--in this patient induced by the pleural mesothelioma and less by the preperitoneal leiomyoma--is of similarly infrequent occurrence. Tumors of epithelial or mesenchymal origin may cause hypoglycemia as a result of peptide secretion, exerting an insulin-like effect. The detection of IGF-I and IGF-II in the serum confirms the diagnosis. Insulinoma can be differentiated by the absence of hyperinsulinemia.
Seeber
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CT
Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes Gutenberg-Universität Mainz.
Walgenbach
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Dienes
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HP
Junginger
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D001786:Blood Glucose / Q000378:metabolism; D018276:Carcinoma, Medullary / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006393:Hemangiopericytoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D007889:Leiomyoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D008654:Mesothelioma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D010994:Pleura / Q000473:pathology; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery
D001786:Blood Glucose; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II
Ungewöhnliche Häufung von partiell endokrin aktiven Tumoren.