An efficient and convenient procedure for the synthesis of N(alpha)-Fmoc-O-monobenzyl phosphonotyrosine.
An efficient procedure is described for the synthesis of N(alpha)-Fmoc-O-monobenzyl phosphonotyrosine from the corresponding dibenzyl derivative by monodebenzylation in the presence of sodium iodide. A simple work up procedure removes the by-products and the monobenzylated phosphono product is obtained in high yield.
Handa
B K
BK
Physical Methods Department, Roche Discovery Welwyn, Welwyn Garden City, Hertfordshire, UK.
Hobbs
C J
CJ
D000596:Amino Acids / Q000737:chemistry*; D001593:Benzyl Compounds / Q000138:chemical synthesis*; D005449:Fluorenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010455:Peptides / Q000138:chemical synthesis*; D019000:Phosphotyrosine / Q000031:analogs & derivatives* / Q000737:chemistry
D000596:Amino Acids; D001593:Benzyl Compounds; D005449:Fluorenes; C113500:N(alpha)-fluorenylmethyloxycarbonyl-monobenzyl phosphonotyrosine; D010455:Peptides; D019000:Phosphotyrosine