Caffeine abstinence augments the systolic blood pressure response to adenosine in humans.
Blood pressure and heart rate responses to adenosine infusion (35, 70, and 140 microg/kg/min, intravenously) were studied in 7 healthy men after 6, 30, 78, 150, and 318 hours of abstinence from regular caffeine use. The finding that caffeine abstinence augmented the systolic pressor response (from -1 +/- 2 mm Hg at 6 hours to +9 +/- 2 mm Hg at 318 hours; p = 0.01) but not the tachycardic response to adenosine has implications for current clinical and research applications of this purine.
Rongen
G A
GA
Division of Cardiology, Mount Sinai Hospital, and Centre for Cardiovascular Research, University of Toronto, Ontario, Canada.
Brooks
S C
SC
Ando
S
S
Notarius
C F
CF
Floras
J S
JS
D000241:Adenosine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002110:Caffeine / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1 / Q000502:physiology; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; D002110:Caffeine; D000241:Adenosine