Aluminum alters intracellular calcium homeostasis in vitro.
The present paper reports data regarding the influence of aluminum, at micromolar concentrations, on intracellular calcium homeostasis. Al3+ modifies Ca2+ uptake in the endoplasmic reticulum (ER), accelerates Ca2+ release from mitochondria and strongly inhibits Ca2+-ATPase activity with a consequent high-level calcium accumulation inside the cell. These results suggest that Al3+ neurotoxicity may be related to an alteration of the intracellular calcium regulatory system.
Gandolfi
L
L
Dipartimento di Scienze Farmaceutiche, Università di Padova, Padova, Italy.
Stella
M P
MP
Zambenedetti
P
P
Zatta
P
P
D000535:Aluminum / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry; D005456:Fluorescent Dyes / Q000378:metabolism; D006706:Homeostasis; D007424:Intracellular Fluid / Q000201:enzymology / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism; D009930:Organic Chemicals; D051381:Rats; D017208:Rats, Wistar; D019284:Thapsigargin / Q000737:chemistry
D004791:Enzyme Inhibitors; D005456:Fluorescent Dyes; D009930:Organic Chemicals; C071336:calcium green; D019284:Thapsigargin; D000535:Aluminum; D000252:Calcium-Transporting ATPases; D002118:Calcium