title: [Blood groups and structure-activity relations].
abstract: In the recent years, advances in biochemistry and molecular genetics have contributed to establish the structure of the genes and proteins from most of the 23 blood group systems presently known. From these findings, five functional classes of molecules can be schematically distinguished: (i) transporters and channels, (ii) receptors for ligands, viruses, bacteria and parasites, (iii) adhesion molecules, (iv) enzymes, and (v) structural proteins. Recent advances on these molecules will be reviewed, particularly by illustrating available structure-function relationships.
authors.affiliation: INSERM U76 et Institut national de la transfusion sanguine, Paris, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Cartron
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry / Q000502:physiology; D001789:Blood Group Antigens / Q000737:chemistry / Q000502:physiology*; D001798:Blood Proteins / Q000737:chemistry / Q000502:physiology; D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000502:physiology; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000378:metabolism; D016695:Glycosyltransferases / Q000737:chemistry / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology; D008024:Ligands; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology; D008666:Metalloendopeptidases / Q000737:chemistry / Q000502:physiology; D008958:Models, Molecular; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D001789:Blood Group Antigens; D001798:Blood Proteins; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D007473:Ion Channels; D008024:Ligands; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D016695:Glycosyltransferases; D000110:Acetylcholinesterase; D008666:Metalloendopeptidases
vernacular_title: Groupes sanguins et relation structure-fonction.