Routine vaccination and vaccine-preventable infections in children born to human immunodeficiency virus-infected mothers. European Collaborative Study.
Information on vaccinations and vaccine-preventable infections collected in a prospective study of children born to human immunodeficiency virus (HIV)-infected mothers was analysed for reports of adverse reactions and to estimate the clinical efficacy of vaccines. No vaccinated, HIV-infected child developed measles (56 child-years' follow-up), mumps (33), rubella (33) or pertussis (239), and only one adverse reaction - to Bacillus Calmette-Guerin (BCG) - was reported. These findings provide limited evidence of the safety and efficacy of routine vaccination of HIV-infected children.
Dunn
D T
DT
Department of Epidemiology and Public Health, Institute of Child Health, London, UK.
Newell
M L
ML
Peckham
C S
CS
Vanden Eijden
S
S
D002644:Chickenpox / Q000517:prevention & control; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000151:congenital / Q000635:transmission*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008457:Measles / Q000517:prevention & control; D009107:Mumps / Q000517:prevention & control; D009164:Mycobacterium Infections / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012306:Risk; D012409:Rubella / Q000517:prevention & control; D014611:Vaccination / Q000009:adverse effects; D014917:Whooping Cough / Q000517:prevention & control