title: 2D 1H and 13C NMR evidence for stereoselective formation of a new bond C-N, C-S or C-C in the reaction of ivalin acetate with substituted pyrimidines.
abstract: Several pyrimidine derivatives of ivalin acetate were synthesized as potential anti HIV agents. High stereoselective Michael addition to ivaline acetate was observed and a new C-C, C-N or C-S bond was formed. 2D NMR 1H and 13C as well as X-ray crystallographic studies were performed on the compounds herein described to establish the structure and stereochemistry.
authors.affiliation: University Nacional Autonoma de México, Instituto de Química, México, D.F., México.
authors.forename: E
authors.initials: E
authors.lastname: Diaz
authors.forename: J L
authors.initials: JL
authors.lastname: Nava
authors.forename: H
authors.initials: H
authors.lastname: Barrios
authors.forename: B
authors.initials: B
authors.lastname: Quiroz
authors.forename: A
authors.initials: A
authors.lastname: Guzman
authors.forename: L
authors.initials: L
authors.lastname: León
authors.forename: A
authors.initials: A
authors.lastname: Fuentes
mesh_terms: D000478:Alkylation; D019380:Anti-HIV Agents / Q000737:chemistry*; D002244:Carbon; D018360:Crystallography, X-Ray; D007783:Lactones; D008956:Models, Chemical; D008958:Models, Molecular; D009584:Nitrogen; D011487:Protein Conformation; D011743:Pyrimidines / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*; D013237:Stereoisomerism; D013455:Sulfur
chemical_list: D019380:Anti-HIV Agents; D007783:Lactones; D011743:Pyrimidines; D012717:Sesquiterpenes; C049171:ivalin; D013455:Sulfur; D002244:Carbon; D009584:Nitrogen