Effect of Helicobacter pylori infection on gastric juice pH.
BACKGROUND
How Helicobacter pylori infection affects gastric acid secretion is still unclear.


METHODS
Gastric juice pH, ammonia concentration in gastric juice, serum gastrin level, and grade of gastritis in accordance with the Sydney System were determined for patients with gastric ulcer (GU) and duodenal ulcer (DU) before and after treatment with lansoprazole and amoxicillin, and results were compared with those of H. pylori-negative controls.


RESULTS
Scores for H. pylori density, atrophy, metaplasia, and activity of gastritis in the corpus were higher in patients with GU, especially those with proximally located GU, than in those with DU. Gastric juice pH was significantly higher in GU patients than in DU patients and controls. After H. pylori eradication, gastric juice pH and serum gastrin levels in both GU and DU patients were significantly decreased to control levels. In patients without eradication, no significant changes in these factors were observed.


CONCLUSIONS
These findings suggest that H. pylori infection and gastritis in the corpus suppress acid secretion and increase gastric juice pH, resulting in hypergastrinemia, and that eradication of H. pylori normalizes acid secretion and serum gastrin levels.
Furuta
T
T
First Dept. of Medicine, Hamamatsu University School of Medicine, Japan.
Baba
S
S
Takashima
M
M
Futami
H
H
Arai
H
H
Kajimura
M
M
Hanai
H
H
Kaneko
E
E
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000641:Ammonia / Q000032:analysis; D000658:Amoxicillin / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000737:chemistry*; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D054328:Proton Pump Inhibitors; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology*
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D005755:Gastrins; D010406:Penicillins; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D000641:Ammonia; D000658:Amoxicillin; D009853:Omeprazole