title: Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives.
abstract: Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti-trypanosomal agents. The compounds were prepared in good to excellent yields in 2-3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
authors.forename: H
authors.initials: H
authors.lastname: Cerecetto
authors.forename: R
authors.initials: R
authors.lastname: Di Maio
authors.forename: G
authors.initials: G
authors.lastname: Ibarruri
authors.forename: G
authors.initials: G
authors.lastname: Seoane
authors.forename: A
authors.initials: A
authors.lastname: Denicola
authors.forename: G
authors.initials: G
authors.lastname: Peluffo
authors.forename: C
authors.initials: C
authors.lastname: Quijano
authors.forename: M
authors.initials: M
authors.lastname: Paulino
mesh_terms: D000818:Animals; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D012664:Semicarbazones; D014344:Trypanocidal Agents