title: [Heparin-induced type II thrombocytopenia within the scope of high dose chemotherapy with subsequent stem cell rescue].
abstract: We report on a 17-year-old young man with rhabdomyosarcoma in the right parotid area. Relapse therapy was performed with high dose chemotherapy and consecutive autologous stem cell rescue. During this therapy heparin-induced thrombocytopenia was diagnosed. Because of its proven antithrombotic activity Danaparoid-Sodium, a natural low molecular glycosaminoglycan preparation, was used for further antithrombotic prophylaxis. We discharged our patient from the laminar air flow unit six months ago. The alternative antithrombotic therapy was tolerated without any problems. No bleeding events occurred, thrombotic complications and veno-occlusive disease of the liver were avoided.
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin Jussuf Ibrahim, Jena.
authors.forename: M
authors.initials: M
authors.lastname: Sauer
authors.forename: B
authors.initials: B
authors.lastname: Gruhn
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
authors.forename: W
authors.initials: W
authors.lastname: Altermann
authors.forename: F
authors.initials: F
authors.lastname: Zintl
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002809:Chondroitin Sulfates / Q000008:administration & dosage; D003871:Dermatan Sulfate / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D018380:Hematopoietic Stem Cell Transplantation; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006497:Heparan Sulfate / Q000008:administration & dosage; D006801:Humans; D008297:Male; D010307:Parotid Neoplasms / Q000097:blood / Q000188:drug therapy*; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D012208:Rhabdomyosarcoma / Q000097:blood / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D004338:Drug Combinations; D006493:Heparin; D006497:Heparan Sulfate; C035838:danaparoid
vernacular_title: Heparin-induzierte Thrombozytopenie Typ II im Rahmen einer Hochdosis-Chemotherapie mit anschliessender Stammzellrescue.