[Design of stimulating agents of non-specific resistance system].
The paper briefly reviews a study on the design of drugs enhancing the body's nonspecific resistance to pathogenic agents. To examine the potential regulatory effects on cytokine function was a main trend. The interferon inductor ridostin, dsRNA of microbiological origin, cytokines, as well as the recombinant probiotic strain yielding interferon alpha-2 synthesis were used as a pharmacological agent. This was shown by using a wide range of experimental models wherein these preparations activated the components of the non-specific resistance system resulting in the host's increased capacity to eliminate invasive agents and transformed cells.
Masycheva
V I
VI
Danilenko
E D
ED
Pustoshilova
N M
NM
Beliavskaia
V A
VA
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D015195:Drug Design; D004351:Drug Resistance / Q000502:physiology*; D007369:Interferon Inducers / Q000494:pharmacology; D051379:Mice; D019936:Probiotics / Q000494:pharmacology; D012330:RNA, Double-Stranded / Q000494:pharmacology; D012331:RNA, Fungal / Q000494:pharmacology; D011994:Recombinant Proteins / Q000494:pharmacology
D016207:Cytokines; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D011994:Recombinant Proteins; C076741:ridostin
Sozdanie sredstv stimuliatsii sistemy nespetsificheskoĭ rezistentnosti.