title: Restoration of irradiated patients using osseointegrated implants: current perspectives.
abstract: BACKGROUND
  The success rates of osseointegrated implants used to restore patients who were irradiated for head and neck tumors are influenced by radiation-induced changes in the hard and soft tissues.
  
  
  OBJECTIVE
  This article examined, by review of the literature, current perspectives on the restoration of irradiated patients using osseointegrated implants.
  
  
  RESULTS
  In published reports that investigated both intraoral and extraoral applications, irradiation decreased implant success rates and the amount of reduction was dependent on the location within the craniofacial skeleton. The limited number of implants and patients in these studies precludes definitive conclusions regarding the efficacy of placing implants into irradiated tissues. The implants placed into the irradiated anterior mandible have demonstrated an acceptable implant success rate of 94% to 100% with a minimal risk of osteoradionecrosis. The efficacy of implants in the posterior mandible has not been examined. Implant success rates ranged from 69% to 95% in the irradiated maxilla for intraoral applications. Extraoral applications demonstrated excellent implant success rates in the temporal bone (91% to 100%). The rates in the anterior nasal floor have varied from 50% to 100%. The implant success rates in the frontal bone decreased as the length of the studies increased (96% to 33%). The long-term efficacy of implants in the irradiated frontal bone is poor.
authors.affiliation: Section of Advanced Prosthodontics and Hospital Dentistry, University of California, Los Angeles, School of Dentistry, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Nishimura
authors.forename: E
authors.initials: E
authors.lastname: Roumanas
authors.forename: J
authors.initials: J
authors.lastname: Beumer
authors.forename: P K
authors.initials: PK
authors.lastname: Moy
authors.forename: K T
authors.initials: KT
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D016371:Cranial Irradiation / Q000009:adverse effects*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D006931:Hyperbaric Oxygenation; D007568:Jaw / Q000528:radiation effects*; D009295:Nasal Bone / Q000000981:diagnostic imaging; D016348:Osseointegration / Q000528:radiation effects*; D010025:Osteoradionecrosis / Q000209:etiology / Q000517:prevention & control; D011859:Radiography; D013701:Temporal Bone / Q000000981:diagnostic imaging