title: Variability analysis of HIV-1 gp120 V3 region: IV. Distribution functions for intra- and inter-subtype amino acid hamming distances.
abstract: Distribution functions for intra- and inter- HIV-1 V3-loop subtypes amino acid Hamming distances were calculated (850 V3-loop sequences from the Los Alamos HIV-1 Database (1996) were used). These functions have pronounced bell-like shape. Such shapes of the histograms for HIV-1 V3 intra- and inter-subtype distriutions are discussed to confirm the applicability of different hierarchical cluster procedures for HIV-1 V3 classification. Two-mode distribution for the subtype E could sertificate that this subtype includes two thinner taxons.
authors.affiliation: Moscow Institute of Physics and Technology, Faculty of Physicochemical Biology, Department of Molecular Biophysics, Dolgoprudny, Moscow region, Russia.
authors.lastname: Shchelkanov MYu
authors.forename: N S
authors.initials: NS
authors.lastname: Starikov
authors.forename: I V
authors.initials: IV
authors.lastname: Yaroslavtsev
authors.forename: P O
authors.initials: PO
authors.lastname: Tsvetkov
authors.forename: A N
authors.initials: AN
authors.lastname: Yudin
authors.forename: M V
authors.initials: MV
authors.lastname: Denisov
authors.forename: A A
authors.initials: AA
authors.lastname: Slavsky
authors.forename: A A
authors.initials: AA
authors.lastname: Vedenov
authors.forename: E V
authors.initials: EV
authors.lastname: Karamov
mesh_terms: D000596:Amino Acids; D015699:HIV Envelope Protein gp120 / Q000737:chemistry*; D006801:Humans; D008432:Mathematical Computing; D010446:Peptide Fragments / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments