title: HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology.
abstract: Human immunodeficiency virus type-1 (HIV-1) manipulates fundamental host cell processes in sophisticated ways to achieve optimum replicative efficiency. Recent studies have provided new details on the molecular interactions of HIV-1 with its host cell. For example, HIV-1 encodes a protein that regulates transcriptional elongation by interacting with a cellular cyclin-dependent kinase, another that activates the specific nuclear export of viral RNA, and several others that affect the intracellular trafficking of viral and host cell proteins. Detailed analysis of the interplay between these viral proteins and normal cellular activities has provided new insights into central questions of virology and host cell biology.
authors.affiliation: Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North-Mailstop C2-023, Seattle, Washington 98109-1024, USA. memerman@fhcrc.org.
authors.forename: M
authors.initials: M
authors.lastname: Emerman
authors.forename: M H
authors.initials: MH
authors.lastname: Malim
mesh_terms: D000818:Animals; D015693:Gene Products, nef / Q000502:physiology; D015694:Gene Products, rev / Q000502:physiology; D015696:Gene Products, tat / Q000502:physiology; D005814:Genes, Viral; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D054298:Human Immunodeficiency Virus Proteins; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic; D054334:Viral Regulatory and Accessory Proteins / Q000235:genetics / Q000502:physiology*; D054311:nef Gene Products, Human Immunodeficiency Virus; D054321:rev Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus; D000086082:Viroporin Proteins
chemical_list: D015693:Gene Products, nef; D015694:Gene Products, rev; D015696:Gene Products, tat; D054298:Human Immunodeficiency Virus Proteins; D008565:Membrane Proteins; D012367:RNA, Viral; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; D054311:nef Gene Products, Human Immunodeficiency Virus; D054321:rev Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins