title: Role of antiphospholipid antibodies in human reproduction.
abstract: The aim of this study was to evaluate the role of antiphospholipid antibodies (APA) in human reproduction. The investigation included 150 patients with systemic lupus erythematosus (SLE), and a group of 931 women, with the history of recurrent spontaneously miscarried pregnancies of unknown origin, even after a detailed examination in obstetric-gynecological institution. APA were investigated by means of tests to lupus anticoagulant (LA), applying a set of coagulation tests, including two tests with viper's poison, and cardiolipin antibodies (ACL) were determined by a standard immunoenzyme method, where a cardiolipin (Sigma, USA) was used as an antigen. The analysis of obstetric history in women with SLE has shown a considerable increase in frequency of obstetric complications in APA-positive group of patients (p < 0.001). Screening-examination to APA, proved its presence in 254 of the total of 931 women (27%), and a complete evaluation of the positive group enabled the establishing of SLE diagnosis in 13 patients, in accordance with the valid criteria of the disease.
authors.affiliation: Clinical Center Bezanijska Kosa, Belgrade.
authors.forename: L
authors.initials: L
authors.lastname: Stojanović
mesh_terms: D000026:Abortion, Habitual / Q000150:complications / Q000276:immunology*; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D016736:Antiphospholipid Syndrome / Q000150:complications; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology; D011256:Pregnancy Outcome
chemical_list: D017152:Antibodies, Antiphospholipid