title: [A case report of esophageal carcinoma with grade 3 response by preoperative chemotherapy using CDDP/5-FU/LV].
abstract: A 67-year-old man was diagnosed as having a type 3 advanced esophageal carcinoma by barium swallow and endoscopy. Biopsy specimens showed well-differentiated squamous cell carcinoma with positive immunostaining for p53, C-erb B-2 and negative for bcl-2. Two courses of chemotherapy using 5-FU, leucovorin and CDDP were performed before operation. Because no cancer cells were present in the surgical specimens, the effect was evaluated as grade 3. This neoadjuvant chemotherapy may be effective for esophageal carcinoma with a possible apoptosis mechanism.
authors.affiliation: First Dept. of Surgery, Nippon Medical School.
authors.forename: K
authors.initials: K
authors.lastname: Bando
authors.forename: M
authors.initials: M
authors.lastname: Onda
authors.forename: M
authors.initials: M
authors.lastname: Miyashita
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Takita
authors.forename: T
authors.initials: T
authors.lastname: Matsutani
authors.forename: K
authors.initials: K
authors.lastname: Okawa
authors.forename: K
authors.initials: K
authors.lastname: Sasajima
authors.forename: Y
authors.initials: Y
authors.lastname: Ujihara
authors.forename: K
authors.initials: K
authors.lastname: Takubo
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D009367:Neoplasm Staging; D011300:Preoperative Care
chemical_list: D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil