title: Effect of finasteride on serum concentrations of dihydrotestosterone and testosterone in three clinically normal sexually intact adult male dogs.
abstract: OBJECTIVE
  To determine the effect of finasteride at dosages of 0, 10, 0.25, and 0.50 mg/kg of body weight, PO, q 24 h, for 7 days) in a Latin square design with repeated measures. Blood was obtained before and on days 1, 2, 4, and 7 of treatment; 3 blood samples were obtained at 20 minute intervals to detect pulsatile secretion of DHT and T. Dogs were untreated at least 2 weeks between treatments.
  
  
  RESULTS
  Finasteride at all doses was associated with a mean decrease in concentration of DHT of 55% (range, 155 +/- 32.3 pg/ml to 70 +/- 15 pg/ml), but had no effect on concentration of T (before treatment, 2.6 +/- 0.38 ng/ml; after treatment, 2.2 +/- 0.63 ng/ml).
  
  
  CONCLUSIONS
  Finasteride at these doses significantly decreased serum concentration of DHT in sexually intact adult male dogs. Concentrations of DHT and T before and 7 days after treatment did not differ by dosage of finasteride administered.
  
  
  CONCLUSIONS
  Finasteride (5 mg; 1 tablet) may be a drug of choice for treatment of benign prostatic hypertrophy in 10- to 50-kg dogs.
authors.affiliation: Department of Veterinary Clinical Sciences, Washington State University, Pullman 99164, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kamolpatana
authors.forename: S D
authors.initials: SD
authors.lastname: Johnston
authors.forename: S K
authors.initials: SK
authors.lastname: Hardy
authors.forename: S
authors.initials: S
authors.lastname: Castner
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D013196:Dihydrotestosterone / Q000097:blood*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D018120:Finasteride / Q000494:pharmacology*; D008297:Male; D012016:Reference Values; D012741:Sexual Maturation; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
chemical_list: D013196:Dihydrotestosterone; D013739:Testosterone; D018120:Finasteride