[Effect of somatostatin on the chronotropic effect caused by vagal nerve stimulation by a single stimulus].
In anesthetised cats, vagal stimulation with a single pulse burst evoked a negative chronotropic effect. Somatostatin prolonged the baseline cardiac cycle, diminished inhibitory tonic vagal effect, and increased irs latency. This peptide effect was associated with a narrowing of an area in the cardiac cycle over which even small vagal burst produced a sharp alteration of the sinus node responsiveness to vagal influences.
Osadchiĭ
O E
OE
Kuban Medical Academy, Krasnodar, Russia.
Pokrovskiĭ
V M
VM
D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology*; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
D013004:Somatostatin
Deĭstvie somatostatina na dinamiku khronotropnogo éffekta pri razdrazhenii bluzhdaiushchego nerva odinochnym stimulom.