title: [Radiation induced tumors].
abstract: Radiations at cellular level produce different effects, depending on type of radiation and irradiated tissue. The radiation-induced cancers are associated to non-letals genetics mutations, and to classify like radiation induced tumors is necessary that appear in the treatment volume, a long latency period (years), histolo-different to the primary lesion, enough doses quantitatively and that exists a greater incidence in the irradiated populations. The genetics mutations affect at tumoral suppressors gen(Gen RB I, p53, BRCA I, BRCA 2) and repressors gen (hMSH 2, hMLH I,...), they could be longer and multifocals mutations, and produce lack of cellular control and a greater predisposition to develop tumors and a probable risk of increment of radiosensitivity. We present some of the more representatives studies about radiation-induced tumors.
authors.affiliation: Servicio de Oncología Radioterápica, Hospital Universitario Virgen del Rocío, Sevilla.
authors.forename: L
authors.initials: L
authors.lastname: Gutiérrez Bayard
authors.forename: L
authors.initials: L
authors.lastname: Delgado López
authors.forename: C
authors.initials: C
authors.lastname: Tirado Bejarano
authors.forename: A
authors.initials: A
authors.lastname: Gómez Puerto
authors.forename: J L
authors.initials: JL
authors.lastname: García Fernández
mesh_terms: D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000145:classification / Q000235:genetics / Q000473:pathology
vernacular_title: Tumores radioinducidos.