Neuropeptide Y lowers blood glucose in anaesthetized rats via a Y5 receptor subtype.
We have investigated the receptor subtype mediating effects of neuropeptide Y (NPY) on blood glucose concentrations. In anaesthetized rats a 120 min i.v. infusion of 2 microg/kg/min NPY lowered blood glucose by 26 mg/dl. This was mimicked by the same dose of peptide YY (PYY), NPY2-36, PYY3-36 and [Leu31,Pro34]NPY but not by NPY13-36, PYY13-36 or rat or human pancreatic polypeptide. The effects of NPY and [Leu31,Pro34]NPY were not inhibited by 10 microg/kg/min BIBP 3226. Neither treatment significantly altered plasma insulin concentrations. We conclude that NPY lowers blood glucose concentrations via a Y5 receptor subtype, i.e. a subtype which has also been implicated in stimulation of food intake.
Bischoff
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A
Medizinische Klinik, Klinikum Essen, Germany.
Michel
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MC
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology; D019894:Peptide YY / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors / Q000502:physiology*
C092926:BIBP 3226; D001786:Blood Glucose; D009478:Neuropeptide Y; D010446:Peptide Fragments; D017476:Receptors, Neuropeptide Y; D019894:Peptide YY; D001120:Arginine