[The effects of medazepam on memory trace reproduction during learning and amnesia in aggressive and submissive C57Bl/6J mice].
Experiments were conducted on C57B1 mice to study the role of the social status on the reproduction of a conditioned reaction of passive avoidance and the effect of medazepam on the processes of reproduction. Aggressive and submissive animals were selected according to the test for agonistic confrontations. No effect of the animals' social status on the formation of a conditioned habit was revealed, but a significant increase in the level of defecation was recorded in the aggressive mice. Medazepam administration before the test reduced the reproduction of the conditioned reaction only in the control mice. An amnestic effect blocked reproduction in control and submissive mice but did not change it in the aggressors. Medazepam restored the amnestic memory trace only in submissive individuals. In aggressive mice it reduced the emotional response but did not change reproduction. The data obtained suggest that variations of the social status determine both the behavioral responsiveness to training and the changes in reproduction in response to medazepam.
Dubrovina
N I
NI
Laboratory of Memory Regulation Mechanisms, Russian Academy of Medical Sciences, Novosibirsk, Russia.
Popova
E V
EV
Il'iuchenok
R Iu
RIu
D000374:Aggression / Q000187:drug effects*; D000647:Amnesia / Q000503:physiopathology*; D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D004291:Dominance-Subordination; D007858:Learning / Q000187:drug effects*; D008297:Male; D008472:Medazepam / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000502:physiology*
D014151:Anti-Anxiety Agents; D008472:Medazepam
Effekty medazepama na vosproizvedenie sleda pamiati pri obuchenii i amnezii u agressivnykh i submissivnykh mysheĭ linii C57Bl/6J.