[Dynamics of interferon induction in albino mice by interferon inducer ridostin administered by various routes].
The time dependence of interferon production in blood, tissues of the respiratory tract, brain and olfactory tract of mice BALB/c was investigated after administration of the interferon inductor ridostin by various routes. Intraperitoneal injection of ridostin in a dose of 5 mg/kg induced intensive accumulation of interferon in the blood serum with the peak in 8 hours (2560 U/0.2 ml) while no interferon was detected in the tissues of the respiratory tract and brain of the animals. Intracerebral injection of ridostin in the same dose induced accumulation of interferon in both the tissues of the brain (maximum 160 U/0.2 ml in 24 hours) and the blood serum (maximum 1280 U/0.2 ml in 8 hours). After respiratory administration of ridostin interferon was detected only in the site of the administration in the tissues of the upper respiratory tract and lungs of the mice.
Bulychev
L E
LE
Research Institute of Aerobiology, State Research Centre of Virology and Biotechnology VECTOR, Ministry of Public Health of the Russian Federation, Novosibirsk Region, Koltsovo.
Goncharova
E P
EP
Ryzhikov
A B
AB
Masycheva
V I
VI
P'iankova
O G
OG
Pliasunov
I V
IV
Poryvaev
V D
VD
Kotliarov
L A
LA
Kolesnikova
N G
NG
D000280:Administration, Inhalation; D000818:Animals; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007369:Interferon Inducers / Q000008:administration & dosage / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009833:Olfactory Pathways / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000008:administration & dosage / Q000494:pharmacology*; D012331:RNA, Fungal / Q000008:administration & dosage / Q000494:pharmacology*; D012137:Respiratory System / Q000378:metabolism
D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; C076741:ridostin; D007372:Interferons
Izuchenie dinamiki interferonoobrazovaniia v organizme belykh mysheĭ pri razlichnykh putiakh vvedeniia induktora interferona ridostina.