Fungitoxic activity of some cytochalasins and their derivatives on Phytophthora species.
The activity of cytochalasin B was tested on 8 Phytophthora species, while the same toxin, some of its derivatives and natural analogues, namely cytochalasin F and deoxaphomin, were assayed at 2 x 10(-5) - 2 x 10(-4) M on the most sensitive species, P. cactorum. A significant inhibitory activity on P. cactorum was shown by cytochalasin B, its 7-monoacetyl derivative, and deoxaphomin. The hydroxy group at C-20 and the conformational freedom of the macrocyclic ring proved to be important structural features for this activity. The 7-hydroxy group at C-7 appeared to have no influence on this toxicity, while a size reduction associated with the carbocyclic nature of the macrocycle seems to lightly increase the activity. The 7-O-acetylcytochalasin B showed selective toxic activity on P. cactorum at the tested concentration, thus suggesting a possible use as a fungicide for this compound.
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Dipartimento di Scienze Chimico-Agrarie, Università di Napoli Federico II, Portici, Italy.
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Andolfi
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D003572:Cytochalasins / Q000737:chemistry / Q000633:toxicity*; D010838:Phytophthora / Q000187:drug effects*; D013045:Species Specificity; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D003572:Cytochalasins