[Overproduction of tumor necrosis factor-alpha in African patients with HIV-1 infection, cachexia and low tri-iodothyronine syndrome].
Sick euthyroid syndrome characterized by low triiodothyronine (T3) levels is observed in advance stages of HIV infection. The purpose of this prospective study was to determine if proinflammatory cytokines play and role in the pathogenesis of this syndrome in HIV-1-infected patients. Serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1 beta were measured in 40 African patients presenting HIV-1 infection associated with low T3 levels in 20 cases (group I) and normal or elevated T3 levels in 20 cases (group II). Elevation of serum TNF-alpha levels was more common and mean serum TNF-alpha level was significantly higher in group I than group II (116 +/- 39 versus 3.05 +/- 0.04 pg/ml; p < 0.01). Serum IL-1 beta levels were not significantly different between the two groups. These findings are consistent with previous experimental data and suggest that sick euthyroid syndrome in cachectic HIV-1 infected patients may be due to overproduction of TNF-alpha.
Tevi-Benissan
C
C
Centre International de Recherche Médicale, Franceville, Gabon.
Di Costanzo
B
B
Gresenguet
G
G
Belec
L
L
D017088:AIDS-Related Opportunistic Infections / Q000097:blood; D000328:Adult; D002100:Cachexia / Q000097:blood* / Q000209:etiology; D005067:Euthyroid Sick Syndromes / Q000097:blood* / Q000209:etiology; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000276:immunology; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000502:physiology; D008297:Male; D011446:Prospective Studies; D013972:Thyrotropin / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis* / Q000096:biosynthesis / Q000502:physiology
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D014284:Triiodothyronine; D013972:Thyrotropin
Surproduction de tumor necrosis factor alpha chez les malades africains infectes par le VIH-1, cachectiques et ayant un syndrome de tri-iodothyronine basse.