[The pharmacological differences between kynurenine- and korazol-induced seizures (the participation of GABA-B receptors and dopamine)].
In experiments of male SHR (nonbred) and C57B1/6 mice [correction of rats] bicucullin intensified corasole-induced convulsions but had no effect on kynurenine convulsions, removed the anticonvulsive effect of phenibut against kynurenine and did not affect the anticonvulsive effect of diazepam against corasole. Phenibut and baclofen reduced the anticonvulsive effect of diazepam against corasole and caffeine. Haloperidol increased kynurenine-induced convulsions and had no effect on those caused by corasole. Dopamine removed the effect of haloperidol. Haloperidol and 6-oxydopamine weakened the sedative effect of phenibut. Blockade of GAMAB-receptors and weakening of dopaminergic activity are important in the mechanisms of kynurenine convulsions, and blockage of GABAA-receptors unrelated to it is important in the mechanisms of corasole convulsions. A functional antagonism in anticonvulsive activity may exist between these receptors. Bicucullin may probably have an effect both on GABAA- and GABAB-receptors.
Lapin
I P
IP
Laboratory of Psychopharmacology, Bechterev St. Petersburg Research Psychoneurological Institute, Russia.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D016009:Chi-Square Distribution; D003292:Convulsants / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D004347:Drug Interactions; D007737:Kynurenine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010433:Pentylenetetrazole / Q000494:pharmacology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D018080:Receptors, GABA-B / Q000187:drug effects / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced*
D000927:Anticonvulsants; D003292:Convulsants; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D007737:Kynurenine; D004298:Dopamine; D010433:Pentylenetetrazole
Farmakologicheskie razlichiia mezhdu kinureninovymi i korazolovymi sudorogami (uchastie GAMKB-retseptorov i dofamina).