[Heparin effect on hydrolysis of fibrin clots in a bull and a man with varying fibrinolytic systems].
Heparin was studied for its effect on the hydrolysis time of clots from desAA fibrin (FB), desAABB fibrin (F0) and fibrinogen (Fg) of a bull and a man by gly-or lys-plasminogen which is activated by the tissue activator. It is shown that heparin in the concentration to 4.6 M does not affect that hydrolysis time of clots from human and bovine Fg and human Fg by gly-plasminogen which is activated by the tissue activator. Heparin increases the hydrolysis time of clots from bovine Fg and F0 by gly-and lys-plasminogen, the tissue activator being present. It firstly increases (in concentrations below 0.5 (microM), and then decreases (in concentrations above 0.5 (microM) the hydrolysis time of clots from human FB, F0 and Fg and bovine FB and F0 by plasmin. In concentration 4.6 microM heparin increases the hydrolysis time of clots from human fibrinogen by fibrinolytic systems. Effect of heparin on fibrinolytic process from the viewpoint of affine interactions between the components of fibrin clots is discussed.
Makogonenko
E M
EM
A.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv.
D000818:Animals; D002417:Cattle; D005337:Fibrin / Q000378:metabolism*; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D006868:Hydrolysis; D008297:Male; D013927:Thrombosis / Q000188:drug therapy* / Q000378:metabolism
D005343:Fibrinolytic Agents; D005337:Fibrin; D006493:Heparin
Vliianie geparina na gidroliz fibrinovykh sgustkov byka i cheloveka razlichnymi fibrinoliticheskimi sistemami.