title: The tetrameric structure of a glutamate receptor channel.
abstract: The subunit stoichiometry of several ligand-gated ion channel receptors is still unknown. A counting method was developed to determine the number of subunits in one family of brain glutamate receptors. Successful application of this method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels. The average conductance of these channels depends on how many subunits are occupied by an agonist.
authors.affiliation: Workgroup Cellular Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Rosenmund
authors.forename: Y
authors.initials: Y
authors.lastname: Stern-Bach
authors.forename: C F
authors.initials: CF
authors.lastname: Stevens
mesh_terms: D001665:Binding Sites; D002460:Cell Line; D004553:Electric Conductivity; D018690:Excitatory Amino Acid Agonists / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists / Q000378:metabolism; D006801:Humans; D008024:Ligands; D046911:Macromolecular Substances; D008954:Models, Biological; D018408:Patch-Clamp Techniques; D011810:Quinoxalines / Q000378:metabolism; D016318:Quisqualic Acid / Q000378:metabolism; D018091:Receptors, AMPA / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000737:chemistry / Q000378:metabolism; D018092:Kainic Acid Receptors / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D000097806:GluK2 Kainate Receptor
chemical_list: D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D008024:Ligands; D046911:Macromolecular Substances; D011810:Quinoxalines; D016318:Quisqualic Acid; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D018092:Kainic Acid Receptors; D011993:Recombinant Fusion Proteins; D000097806:GluK2 Kainate Receptor; C104723:glutamate receptor ionotropic, AMPA 3; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; C063295:5,7-dinitroquinoxaline-2,3-dione