Effects of anti-IL-5 monoclonal antibody on the murine model of nasal allergy.
IL-5 is known to be closely related to the infiltration, activation and proliferation of eosinophils. In this study, we evaluated the in vivo effects of anti-IL-5 monoclonal antibody (mAb) in the murine model of nasal allergy. The mAb treatment inhibited the antigen-induced late phase eosinophilia, but had no effects on the number of basophilic cells. It also inhibited early phase nasal symptoms, and tended to inhibit histamine hypersensitivity. These findings suggest that IL-5 plays an important role in the pathogenesis of allergic nasal disorders.
Asakura
K
K
Department of Otolaryngology, Sapporo Medical University, Japan.
Saito
H
H
Watanabe
M
M
Ogasawara
H
H
Matsui
T
T
Kataura
A
A
D000485:Allergens / Q000009:adverse effects / Q000276:immunology / Q000494:pharmacology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000276:immunology / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000276:immunology / Q000628:therapy; D004347:Drug Interactions; D004802:Eosinophilia / Q000276:immunology; D006632:Histamine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D006634:Histamine H1 Antagonists / Q000276:immunology / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D015848:Interleukin-5 / Q000009:adverse effects / Q000276:immunology* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009296:Nasal Cavity / Q000187:drug effects / Q000276:immunology*; D009297:Nasal Mucosa / Q000187:drug effects / Q000276:immunology; D009299:Nasal Provocation Tests; D012130:Respiratory Hypersensitivity / Q000209:etiology / Q000276:immunology*; D012220:Rhinitis / Q000276:immunology; D012912:Sneezing / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000485:Allergens; D000911:Antibodies, Monoclonal; D006634:Histamine H1 Antagonists; D015848:Interleukin-5; D006632:Histamine