title: Muscarinic elicitation of EEG asymmetry in freely moving rats.
abstract: Averaged frequency spectra (0.5-30 Hz) of electroencephalogram (EEG) were studied in six freely moving rats with chronically implanted electrodes in symmetrical areas of somatosensory cortex. Hemispheric asymmetry in spectra of an ongoing EEG was expressed as a power decrease in 15.6-17.2 Hz band on the left hemisphere and as that in 25.2-27.8 Hz band on the right one. Physostigmine subcutaneous (s.c.) injection (0.25 mg/kg) provoked appearance of the significant left brain bias in 4.7-8.6 Hz range of EEG spectra and the right brain bias in 19.3-21.3 Hz band. These physostigmine effects were counteracted by scopolamine (1.5 mg/kg, s.c.) injected 30 min before. It is suggested that a muscarinic component may be involved in the interhemispheric cooperation associated with cortical theta activity in rats.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142292, Russian Federation. vorobyow@venus.iteb.serpukhov.su
authors.forename: V V
authors.initials: VV
authors.lastname: Vorobyov
authors.forename: E R
authors.initials: ER
authors.lastname: Ahmetova
mesh_terms: D000818:Animals; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects*; D008297:Male; D009068:Movement / Q000502:physiology*; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000494:pharmacology*; D013003:Somatosensory Cortex / Q000502:physiology*
chemical_list: D018727:Muscarinic Antagonists; D010830:Physostigmine; D012601:Scopolamine