title: Evidence for immune system involvement in reflex sympathetic dystrophy.
abstract: Skin biopsies from patients with reflex sympathetic dystrophy were immunostained using a variety of antisera. An incidental finding with S100 staining was the presence of numerous Langerhans cells in the epidermis. All patients had significant pain at the time of biopsy, and all had symptoms refractory to treatment. The potential implications of this finding are discussed.
authors.affiliation: Blond-McIndoe Research Centre, Queen Victoria Hospital, East Grinstead, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: Calder
authors.forename: I
authors.initials: I
authors.lastname: Holten
authors.forename: R M
authors.initials: RM
authors.lastname: McAllister
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002422:Causalgia / Q000276:immunology / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006225:Hand / Q000601:surgery; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D009412:Nerve Fibers / Q000276:immunology / Q000473:pathology; D009416:Nerve Regeneration / Q000276:immunology; D011183:Postoperative Complications / Q000276:immunology / Q000473:pathology; D012019:Reflex Sympathetic Dystrophy / Q000276:immunology* / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism*; D012867:Skin / Q000276:immunology / Q000294:innervation / Q000473:pathology; D013373:Substance P / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D009418:S100 Proteins; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D014446:Tyrosine 3-Monooxygenase; D015740:Calcitonin Gene-Related Peptide