title: Cyanonitrosylmetallates as potential NO-donors.
abstract: The [M(CN)xNOy]n- complexes (where M = Cr(I), Mn(I), Mn(II), Fe(I), Fe(II), Fe(III)) were studied as potential NO-donors using both pharmacological and theoretical semi-empirical methods. Only iron complexes appeared to be pharmacologically active. The quantum chemical calculations indicated that these complexes have the highest predisposition to undergo a nucleophilic attack followed by the NO+ release. The results allowed us to interpret the metabolism of the [M(CN)xNOy]n- complexes in terms of the NO(+)-donation.
authors.affiliation: Department of Inorganic Chemistry, Jagiellonian University, Kraków, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Oszajca
authors.forename: G
authors.initials: G
authors.lastname: Stochel
authors.forename: E
authors.initials: E
authors.lastname: Wasielewska
authors.forename: Z
authors.initials: Z
authors.lastname: Stasicka
authors.forename: R J
authors.initials: RJ
authors.lastname: Gryglewski
authors.forename: A
authors.initials: A
authors.lastname: Jakubowski
authors.forename: K
authors.initials: K
authors.lastname: Cieślik
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D008956:Models, Chemical; D009569:Nitric Oxide / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D011817:Rabbits; D013696:Temperature; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D009942:Organometallic Compounds; D014665:Vasodilator Agents; D009599:Nitroprusside; D009569:Nitric Oxide