title: Ultrasonographic bone velocity in pregnancy: a longitudinal study.
abstract: OBJECTIVE
  Longitudinal changes in bone mass were evaluated with use of ultrasonography and bone remodeling markers in 40 normal pregnant women in relation to their calcium intake.
  
  
  METHODS
  The study took place at the University of Alcalá Hospital in Madrid. Biochemical markers of bone remodeling and ultrasonographic bone propagation velocity in the proximal phalanxes of fingers 2 to 5 were measured in all three trimesters of pregnancy. Wilcoxon, unpaired and paired t tests, and analysis of variance were used.
  
  
  RESULTS
  Ultrasonographic bone propagation velocity (meters per second) was lower in the second and third trimesters of pregnancy (p < 0.0001) compared with the respective preceding trimesters and in the third trimester in the overall group of pregnant women. Tartrate-resistant acid phosphatase and alkaline phosphatase levels increased significantly (p < 0.0001) in parallel with the ultrasonographic bone propagation velocity decrease.
  
  
  CONCLUSIONS
  Gestation was accompanied by a reduction in ultrasonographic bone propagation velocity that was greater in women with low calcium intake.
authors.affiliation: Radiodiagnostics Service, University Hospital, University of Alcalá de Henares, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Aguado
authors.forename: M
authors.initials: M
authors.lastname: Revilla
authors.forename: E R
authors.initials: ER
authors.lastname: Hernández
authors.forename: M
authors.initials: M
authors.lastname: Menéndez
authors.forename: J
authors.initials: J
authors.lastname: Cortés-Prieto
authors.forename: L F
authors.initials: LF
authors.lastname: Villa
authors.forename: H
authors.initials: H
authors.lastname: Rico
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D016723:Bone Remodeling; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002136:Calcium, Dietary / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008137:Longitudinal Studies; D011247:Pregnancy / Q000502:physiology*; D011264:Pregnancy Trimesters; D000071681:Tartrate-Resistant Acid Phosphatase; D014463:Ultrasonography
chemical_list: D002136:Calcium, Dietary; D007527:Isoenzymes; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase