title: Alpha-1-antichymotrypsin bi-allele polymorphism, apolipoprotein-E tri-allele polymorphism and genetic risk of Alzheimer's syndrome.
abstract: The alpha1-antichymotrypsin and apolipoprotein-E polymorphisms were investigated in patients suffering from Alzheimer's syndrome and non-demented psychiatric inpatients as controls. The apolipoprotein E allele 4, well known as risk factor, tended to be elevated in the index group. The frequency of the alpha1-antichymotrypsin allele A was significantly increased in patients with Alzheimer's syndrome: 0.647 vs. 0.483 (chi-square test, p < 0.05). We conclude that, apart from the apolipoprotein E allele 4, the alpha1-antichymotrypsin allele A possibly represents a second genetic factor increasing individual's risk for Alzheimer's syndrome.
authors.affiliation: Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Thome
authors.forename: A
authors.initials: A
authors.lastname: Baumer
authors.forename: J
authors.initials: J
authors.lastname: Kornhuber
authors.forename: M
authors.initials: M
authors.lastname: Rösler
authors.forename: P
authors.initials: P
authors.lastname: Riederer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D000514:alpha 1-Antichymotrypsin / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D000514:alpha 1-Antichymotrypsin