title: [Prognostic value of E-cadherin expression in hepatocellular carcinoma].
abstract: Expression of E-cadherin (E-cad) was investigated immunohistologically in 91 cases of operated hepatocellular carcinomas. An alteration of E-cad immunodetection was found in 56% of tumours. These alterations were correlated with histopathologic features of prognostic value including tumour size (> 3 cm), high nuclear grade and mitotic index. Patients with down-regulated E-cad expression had statistically significant shorter survival than the others. Although E-cad immunodetection was an independent prognostic factor, the Cox multivariate analysis showed that its prognostic value was low when compared to other prognostic factors.
authors.affiliation: Service d'Anatomie et Cytologie Pathologiques, Faculté de médecine, Marseille.
authors.forename: S
authors.initials: S
authors.lastname: Garcia
authors.forename: F
authors.initials: F
authors.lastname: Martini
authors.forename: C
authors.initials: C
authors.lastname: De Micco
authors.forename: L
authors.initials: L
authors.lastname: Andrac
authors.forename: P
authors.initials: P
authors.lastname: Sappa
authors.forename: J
authors.initials: J
authors.lastname: Hardwigsen
authors.forename: M N
authors.initials: MN
authors.lastname: Lavaut
authors.forename: Y P
authors.initials: YP
authors.lastname: Le Treut
authors.forename: C
authors.initials: C
authors.lastname: Charpin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000096:biosynthesis*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D015820:Cadherins
vernacular_title: Valeur pronostique de l'expression de l'E-cadhérine dans les hépatocarcinomes.