G proteins and Na+/H+ exchange.
The Na+/H+ exchangers are important regulators of intracellular pH, cell volume, and cell proliferation. They exist in all cells with a cell-specific pattern of isoform expression. Na+/H+ exchangers are regulated by a variety of extracellular stimuli which activate G-protein-coupled receptors and receptor tyrosine. Heterotrimeric G proteins regulated distinct signaling pathways, some of which in turn regulate the activity of Na+/H+ exchangers. This review describes the recent findings concerning the molecular mechanisms of the G-protein-dependent regulation of Na+/H+ exchangers.
Voyno-Yasenetskaya
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Department of Pharmacology, University of Illinois at Chicago College of Medicine 60612-7343, USA. tvy@uic.edu
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism / Q000502:physiology*
D018160:Receptors, Cytoplasmic and Nuclear; D017923:Sodium-Hydrogen Exchangers; D019204:GTP-Binding Proteins