title: Does a relationship exist between trends in estrogen receptor levels and breast cancer incidence and mortality?
abstract: Estrogen receptor data from 4,049 patients with primary breast cancer treated at the National Cancer Institute of Naples between 1984 and 1996, have been evaluated to analyze temporal trend of this tumor marker. The prevalence rate of estrogen receptor levels falls from >75% in women older than 60 years to <70% in younger patients. The analysis of these data by birth cohort shows a trend very similar to that of breast cancer incidence in Italy, suggesting that the breast cancer appearance could be modulated in different period of life.
authors.affiliation: Servizio di Epidemiologia e Prevenzione, Istituto Nazionale Tumori di Napoli, Via Mariano Semmola, 80131 Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Celentano
authors.forename: M
authors.initials: M
authors.lastname: Montella
authors.forename: P
authors.initials: P
authors.lastname: Bonelli
authors.forename: L
authors.initials: L
authors.lastname: Cecco
authors.forename: M
authors.initials: M
authors.lastname: De Marco
authors.forename: P
authors.initials: P
authors.lastname: Di Cintio
authors.forename: M
authors.initials: M
authors.lastname: Iannuzzo
authors.forename: F
authors.initials: F
authors.lastname: Tuccillo
authors.forename: G
authors.initials: G
authors.lastname: Botti
authors.forename: G
authors.initials: G
authors.lastname: D'Aiuto
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000401:mortality; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008593:Menopause; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D011960:Receptors, Estrogen