title: [Some aspects of interferon formation in white mice].
abstract: White mice weighing 14-16 g were intranasally infected with LD50 of influenza virus (A/Aichi/2/68 strain). High levels both of virus and interferon were detected in the lung. Sufficient virus accumulation in the nasal cavity occurred with low interferon induction. At the same time high blood interferon levels corresponded to sporadic low viremia. Intraperitoneal injection of the interferon inducer ridostin (a pharmacological formulation of dsRNA) to BALB/c mice (18-20 g) in a dose of 5 mg/kg induced intensive blood accumulation of interferon with its peak at 8 hours postadministration (2560 U/0.2 ml), but interferon was not detected in the respiratory tract and brain of these mice. Intranasal (15 mg/kg) and aerogenic (0.4-0.6 mg/kg) administration of ridostin induced interferon mainly in the upper respiratory tract and lung. The regularities found are in agreement with the data on interferon induction by other dsRNA preparations, which makes it necessary to design dosage forms of interferon inducers for respiratory application in influenza.
authors.forename: L E
authors.initials: LE
authors.lastname: Bulychev
authors.forename: E P
authors.initials: EP
authors.lastname: Goncharova
authors.forename: O G
authors.initials: OG
authors.lastname: P'iankova
authors.forename: A N
authors.initials: AN
authors.lastname: Sergeev
authors.forename: A B
authors.initials: AB
authors.lastname: Ryzhikov
authors.forename: O V
authors.initials: OV
authors.lastname: P'iankov
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: V A
authors.initials: VA
authors.lastname: Petrishchenko
mesh_terms: D000818:Animals; D004333:Drug Administration Routes; D005500:Follow-Up Studies; D007369:Interferon Inducers / Q000008:administration & dosage; D007372:Interferons / Q000819:agonists / Q000096:biosynthesis* / Q000235:genetics; D008168:Lung / Q000378:metabolism / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009975:Orthomyxoviridae / Q000254:growth & development / Q000302:isolation & purification; D009976:Orthomyxoviridae Infections / Q000378:metabolism* / Q000821:virology; D012313:RNA / Q000096:biosynthesis; D012330:RNA, Double-Stranded / Q000008:administration & dosage; D012331:RNA, Fungal / Q000008:administration & dosage
chemical_list: D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; C076741:ridostin; D012313:RNA; D007372:Interferons
vernacular_title: Nekotorye aspekty interferonoobrazovaniia v organizme belykh mysheĭ.