Rubrobramide, a cytotoxic and phytotoxic metabolite from Cladobotyrum rubrobrunnescens.
Cladobotrin (1) and rubrobramide (2) were isolated from the culture filtrate of Cladobotryum rubrobrunnescens, a mycophilic deuteriomycete. Rubrobramide (2), possessing a unique oxidized tricyclic system, is a new compound structurally related to flavipucine (3), which also is produced by the fungus. The structure of 2 was determined by spectroscopic methods. Cladobotrin (1) exhibited weak nematicidal activity toward Meldogyne incognita, while 2 showed weak cytotoxic and phytotoxic activities.
Wagner
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C
Department of Biotechnology, University of Kaiserslautern, Germany.
Anke
H
H
Sterner
O
O
D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D000969:Antinematodal Agents / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004988:Ethers, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D006540:Herbicides / Q000302:isolation & purification* / Q000633:toxicity; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000737:chemistry*; D008968:Molecular Conformation; D014407:Tumor Cells, Cultured
D000890:Anti-Infective Agents; D000903:Antibiotics, Antineoplastic; D000969:Antinematodal Agents; D004988:Ethers, Cyclic; D006540:Herbicides; C112371:rubrobramide