Acute renal failure after massive ingestion of gliclazide in a suicide attempt.
Gliclazide, a sulfonlyurea class molecule, is used to control glycaemic levels in non-insulin-dependent diabetes mellitus. Acute and chronic toxicity studies, conducted in various animal species, have demonstrated a very low toxicity. We report a patient who developed acute renal failure due to acute tubular necrosis following a massive ingestion of gliclazide in an suicide attempt. The patient ingested 28 grams of gliclazide; the normal dose of gliclazide is 80 mg one or twice a day. At admission the patient was hypoglycaemia and in a few days became oliguric with an increase in the serum creatinine concentration, but with a normal blood urea nitrogen level. He underwent dialysis and ten days after ingestion of gliclazide, his renal function improved rapidly.
Barracca
A
A
Department of Renal Disease, Azienda Ospedaliera Brotzu, Cagliari, Italy.
Ledda
O
O
Michittu
B
B
Pili
G F
GF
Manca
O
O
Pani
A
A
Altieri
P
P
D000328:Adult; D000818:Animals; D005907:Gliclazide / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000506:poisoning*; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced* / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D013406:Suicide, Attempted
D007004:Hypoglycemic Agents; D005907:Gliclazide