title: Non conventional fractionation in radiotherapy of the musculo-skeletal sarcomas.
abstract: In 1989 we started an accelerated hyperfractionated schedule of radiotherapy (two 1.6 Gy daily fractions) in standard risk localized Ewing's sarcoma of bone, with the aim at reducing late effects in young patients and at improving disease control through a better integration of treatment modalities. From 1991, the same schedule was used in preoperative radiotherapy of adult soft tissue sarcomas of the extremities: the main purpose was to reduce the time to surgery and to evaluate surgical complications in comparison with a previous experience of hypofractionated radiotherapy (one 3 Gy daily fraction). From 1991 to 1997, 76 patients with Ewing's sarcoma and 24 patients with soft tissue sarcoma were treated at our Institution. Results and complication rates are analyzed in comparison with historical data. In Ewing's sarcoma, a correct evaluation of improvement in local control was difficult because of changing treatment policy (bulky disease was not included in the present series). Late effects, as evaluated in patients with a minimum follow-up of 3 years, occurred with similar incidence, but at higher total dose levels in patients treated with accelerated hyperfractionation. In patients with soft tissue sarcomas, incidence of surgical complications is reduced as compared to historical experience. Major problems of wound healing were seen in association with intraoperative brachitherapy boost.
authors.affiliation: Clinical Department of Radiological and Hystopathological Sciences, University of Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Barbieri
authors.forename: G
authors.initials: G
authors.lastname: Frezza
authors.forename: O
authors.initials: O
authors.lastname: Martelli
authors.forename: S
authors.initials: S
authors.lastname: Neri
authors.forename: M
authors.initials: M
authors.lastname: Mercuri
authors.forename: F
authors.initials: F
authors.lastname: Gherlinzoni
authors.forename: G
authors.initials: G
authors.lastname: Bacci
authors.forename: A
authors.initials: A
authors.lastname: Mancini
authors.forename: C
authors.initials: C
authors.lastname: Putti
authors.forename: L
authors.initials: L
authors.lastname: Babini
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001132:Arm; D001859:Bone Neoplasms / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D012509:Sarcoma / Q000532:radiotherapy*; D012512:Sarcoma, Ewing / Q000532:radiotherapy; D016896:Treatment Outcome