title: The screening sensitivity of endoscopy, acid perfusion test and 24-hour pH-monitoring to evaluate esophagitis in patients with heartburn and histological esophagitis.
abstract: The sensitivity of endoscopic examinations, acid perfusion test and 24-hour esophageal pH-monitoring, were studied in patients with heartburn. Thirty six adult patients with histological esophagitis were included in this prospective study. Endoscopy showed esophageal lesion in 18/36 (sensitivity of 50%): esophagitis grade I in 10 (55.6%) and, grade II in eight (44.4%). Acid perfusion test was positive in 10/25 (sensitivity of 40%) of the patients submitted to the test. Twenty-four-hour pH-monitoring was positive in 17/29 patients (sensitivity of 58.6%): eight (61.5%) did not have esophageal lesion at endoscopy, two (25%) had esophagitis grade I and seven (87.5%) had esophagitis grade II. In the patients submitted to 24-hour pH-monitoring, a greater number or reflux episodes in orthostatic position than in supine position (P < 0.0001) was observed. The total number of reflux episodes, the most prolonged reflux and the total pH time < 4 were statistically higher in post-prandial period than during meals (P = 0.005).
authors.affiliation: Department of Gastroenterology, Medical School, University of São Paulo, Brazil.
authors.forename: T
authors.initials: T
authors.lastname: Navarro-Rodriguez
authors.forename: J P
authors.initials: JP
authors.lastname: de Moraes-Filho
authors.forename: E
authors.initials: E
authors.lastname: Arakaki
authors.forename: D
authors.initials: D
authors.lastname: Chinzon
authors.forename: S
authors.initials: S
authors.lastname: Zaterka
authors.forename: K
authors.initials: K
authors.lastname: Iriya
authors.forename: A A
authors.initials: AA
authors.lastname: Laudanna
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016145:Endoscopy, Digestive System; D004941:Esophagitis / Q000175:diagnosis*; D005260:Female; D005744:Gastric Acid; D005764:Gastroesophageal Reflux; D006356:Heartburn / Q000175:diagnosis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010477:Perfusion; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors