title: [Nifurtimox as a prophylactic drug to prevent reactivation in chronic chagasic patients treated with corticoid for associated diseases].
abstract: Patients in the chronic phase of Chagas' disease and receiving corticoid because of concommitant diseases were treated with nifurtimox. We proved in another paper that in the chronic phase of Chagas' disease corticoid use is associated with increased parasitemia, as evaluated by xenodiagnosis. In this study nifurtimox use prevented this increase, and we suggest that in immunocompromised patients with chronic Chagas' disease the use of this drug could be useful.
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Goiás, Brasil.
authors.forename: A
authors.initials: A
authors.lastname: Rassi
authors.forename: V A
authors.initials: VA
authors.lastname: Neto
authors.forename: A F
authors.initials: AF
authors.lastname: de Siqueira
authors.forename: M S
authors.initials: MS
authors.lastname: Leite
mesh_terms: D000328:Adult; D000977:Antiparasitic Agents / Q000627:therapeutic use*; D014355:Chagas Disease / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009547:Nifurtimox / Q000627:therapeutic use*
chemical_list: D000977:Antiparasitic Agents; D005938:Glucocorticoids; D009547:Nifurtimox
vernacular_title: Efeito protetor do nifurtimox contra a reativação parasitária em pacientes cronicamente infectados pelo Trypanosoma cruzi e tratados com corticoide em virtude de afecções associadas.