Multiple agminate Spitz naevi.
We report two patients with multiple agminate Spitz naevi (MASM), a rare disorder. In case 1, a 16-year-old girl, the results of chromosomal investigation of fibroblasts from the affected area (translocation 45, X, t(4; 7) (p14; p22) in a mosaic pattern) suggest that early during embryogenesis a de novo reciprocal translocation has occurred between chromosomes 4 and 7. This resulted in the skin lesions as described on the right shoulder, arm and hand. The melanoma risk in MASM is also discussed.
Hulshof
M M
MM
Department of Dermatology, University Hospital Leiden, The Netherlands.
van Haeringen
A
A
Gruis
N A
NA
Snels
D C
DC
Bergman
W
W
D000293:Adolescent; D001132:Arm; D001706:Biopsy; D002675:Child, Preschool; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006225:Hand; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology; D018332:Nevus, Epithelioid and Spindle Cell / Q000235:genetics* / Q000473:pathology*; D012306:Risk; D012782:Shoulder; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology*; D014178:Translocation, Genetic