Dendritic alterations in cortical pyramidal cells in the sparse fur mouse.
Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in sparse fur (spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both the complexity of the dendritic arbor and in dendritic terminal spine density (60%) in spf/Y mice compared with controls. Such reductions may contribute to behavioral dysfunction observed in spf/Y mice.
Hopkins
K J
KJ
Department of Environmental Toxicology, University of California, Riverside, CA 92521, USA.
McKean
J
J
Mervis
R F
RF
Oster-Granite
M L
ML
D000818:Animals; D048429:Cell Size; D002540:Cerebral Cortex / Q000201:enzymology / Q000473:pathology*; D003712:Dendrites / Q000473:pathology*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009954:Ornithine Carbamoyltransferase / Q000235:genetics*; D017966:Pyramidal Cells / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure
D009954:Ornithine Carbamoyltransferase