A novel substance associated with gallamine-induced myoclonus.
If gallamine or d-tubocurarine gains access to the central nervous system it produces a myoclonus, a synchronized jerking of many skeletal muscles. Each jerk is accompanied by a slow wave in the inferior olive. The jerking continues for 24 h or more after the gallamine or d-tubocurarine can no longer be detected in the CSF. We report here that a novel substance appears in the CSF and persists for a long period of time, possibly as long as the twitching. This substance is not corticotrophin-releasing factor (CRF) nor does CRF or harmaline (a substance causing a tremor by an action on the inferior olive) lead to the appearance of the novel substance. At present the nature of this substance is not known.
Ramzan
I
I
Department of Pharmacy, University of Sydney, NSW, Australia.
Goldsmith
R
R
Burke
W
W
D000818:Animals; D001685:Biological Factors / Q000134:cerebrospinal fluid*; D002415:Cats; D002851:Chromatography, High Pressure Liquid; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D003655:Decerebrate State; D005703:Gallamine Triethiodide / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics / Q000494:pharmacology; D009207:Myoclonus / Q000134:cerebrospinal fluid* / Q000139:chemically induced; D009847:Olivary Nucleus / Q000503:physiopathology; D012680:Sensitivity and Specificity; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology
D001685:Biological Factors; D003346:Corticotropin-Releasing Hormone; D005703:Gallamine Triethiodide; D014403:Tubocurarine