[Does desensitisation of acetylcholine receptors play a physiological role in the neuromuscular synapse?].
After the acetylcholinesterase inhibition, desensitisation of neuro-muscular junctions was found to limit rebundunt activity of postsynaptic membranes and disturb normal transmission. Long-term densensitisation of cholinoreceptors entails shortening of the postsynaptic current decay due, probably, to a high affinity binding the acetylcholine molecules to the desensitised receptors. This may prevent repetitive interactions with active receptors and buffer a certain amount of acetylcholine.
Giniatullin
R A
RA
Kazan State Medical University, Russia.
Magazanik
L G
LG
D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D009469:Neuromuscular Junction / Q000502:physiology*; D010766:Phosphorylation; D011950:Receptors, Cholinergic / Q000378:metabolism / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
D011950:Receptors, Cholinergic; D000110:Acetylcholinesterase; D000109:Acetylcholine
Igraet li fiziologicheskuiu rol' desensitizatsiia kholinoretseptorov v nervno-myshechnom sinapse?