title: Examination of acetaminophen for outpatient management of postoperative pain in children.
abstract: We have examined acetaminophen (paracetamol) dosing for outpatient management of posttonsillectomy pain in children. Forty children, 5-15 years of age, undergoing tonsillectomy and their parents were randomly assigned to use a scheduled administration of acetaminophen in weight appropriate doses, 60 mg.kg-1.24h-1 orally, 90 mg.kg-1.24h-1 rectally, or to use acetaminophen 'as needed' according to present standards (control group). Postoperative pain was assessed by the child using the poker chip tool for the first three days after discharge. The prevalence of pain amongst all the children was high. The second day after discharge 22%-64% of the children in the study group and 36%-73% of the children in the control group rated severe pain. Recommended dose ranges of acetaminophen do not provide sufficient pain relief in children following tonsillectomy. Further studies are required to determine, whether higher doses of acetaminophen or analgesics with different analgesic properties will lead to improved analgesia in children following tonsillectomy.
authors.affiliation: Department of Pharmaceutics, Royal Danish School of Pharmacy, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Rømsing
authors.forename: S
authors.initials: S
authors.lastname: Hertel
authors.forename: A
authors.initials: A
authors.lastname: Harder
authors.forename: M
authors.initials: M
authors.lastname: Rasmussen
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000284:Administration, Oral; D000285:Administration, Rectal; D000293:Adolescent; D000553:Ambulatory Care; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000517:prevention & control; D010351:Patient Discharge; D014068:Tonsillectomy / Q000009:adverse effects
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen