title: Liver transplantation for disulfiram-induced hepatic failure.
abstract: Fulminant hepatitis is a rare but potentially fatal adverse reaction that may occur after the use of disulfiram. A patient without a known history of liver disease was transplanted for fulminant hepatic failure secondary to disulfiram. A high index of suspicion and aggressive therapeutic approaches are essential for the prompt diagnosis and treatment of disulfiram-induced hepatic failure. The clinical presentation, histopathology, treatment, and all cases of disulfiram-induced hepatic failure reported in the English literature are reviewed. The role of orthotopic liver transplantation in a case of disulfiram-induced hepatic failure is discussed.
authors.affiliation: Department of Surgery, Oregon Health Sciences University and Portland Veterans Affairs Medical Center, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Rabkin
authors.forename: C L
authors.initials: CL
authors.lastname: Corless
authors.forename: S L
authors.initials: SL
authors.lastname: Orloff
authors.forename: K G
authors.initials: KG
authors.lastname: Benner
authors.forename: K D
authors.initials: KD
authors.lastname: Flora
authors.forename: H R
authors.initials: HR
authors.lastname: Rosen
authors.forename: A J
authors.initials: AJ
authors.lastname: Olyaei
mesh_terms: D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000601:surgery; D004221:Disulfiram / Q000009:adverse effects*; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000601:surgery*; D006801:Humans; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation; D008297:Male
chemical_list: D000427:Alcohol Deterrents; D004221:Disulfiram