title: Intralymphocyte free magnesium and plasma triglycerides.
abstract: To evaluate the relative effect of hypertension and plasma triglycerides on intralymphocyte magnesium we measured ionized intralymphocyte magnesium (Mg(i)) concentration by means of a fluorimetric method based on the dye Furaptra in 4 groups of subjects: 18 normotensive normotriglyceridemic controls (NTNC), 9 hypertriglyceridemic normotensive patients (HTN), 8 hypertriglyceridemic essential hypertensive patients (HTEH), 17 normotriglyceridemic essential hypertensive patients (NTEH). Hypercholesterolemic, diabetic patients and alcoholics were excluded from the study. Mg(i) was found to be statistically reduced (ANOVA test F=10.41, P=0.0001) in both HTN and HTEH (M+/- SD, HTN: 0.235 +/- 0.01, HTEH: 0.236 +/- 0.01 mmol/l) as compared to both NTNC and NTEH (M +/- SD, NTNC: 0.294 +/- 0.008, NTEH: 0.297 +/- 0.009 mmol/l). A statistically significant negative correlation was found in the population as a whole between Mg(i) and plasma triglycerides (n=52, R= -541, P=0.00004). Our data suggest that hypertriglyceridemia per se and possibly the so-called plurimetabolic syndrome is characterized by low intralymphocyte free magnesium.
authors.affiliation: Institute of Internal Medicine, University of Verona, Policlinico Borgo Roma, Italy. delvap@borgoroma.univr.it
authors.forename: P
authors.initials: P
authors.lastname: Delva
authors.forename: C
authors.initials: C
authors.lastname: Pastori
authors.forename: M
authors.initials: M
authors.lastname: Degan
authors.forename: G
authors.initials: G
authors.lastname: Montesi
authors.forename: A
authors.initials: A
authors.lastname: Lechi
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013050:Spectrometry, Fluorescence; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D008274:Magnesium