The role of protein stability in the cell cycle and cancer.
In addition to the examples mentioned above, other important regulators of cell proliferation such as cyclin D, cyclin E, p21, p27 are all potentially controlled by ubiquitin-mediated proteolysis. In several of these, phosphorylation has been shown to play a role in targeting the proteins for degradation. It remains to be seen how important the SCF pathway and ubiquitin-mediated proteolysis, in general, will become in cancer research. However, it appears that we have only just scratched the surface on the role of these pathways in the control of important regulatory genes. We suspect there will be much more to come from analysis of these fascinating pathways.
Elledge
S J
SJ
Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA. selledge@bcm.tmc.edu
Harper
J W
JW
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division; D050760:Cyclin-Dependent Kinase Inhibitor p27; D010450:Endopeptidases / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009369:Neoplasms / Q000473:pathology*; D010766:Phosphorylation; D011506:Proteins; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D025521:Tumor Suppressor Proteins; D014452:Ubiquitins / Q000502:physiology*; D015003:Yeasts
D018797:Cell Cycle Proteins; D008869:Microtubule-Associated Proteins; D011506:Proteins; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D014452:Ubiquitins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D010450:Endopeptidases