The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis.
The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda > or = 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to determine whether this is a true or false-positive finding. It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis.
Brown
M A
MA
Wellcome Trust Centre for Human Genetics, Headington, Oxford.
Rudwaleit
M
M
Pile
K D
KD
Kennedy
L G
LG
Shatford
J
J
Amos
C I
CI
Siminovitch
K
K
Rubin
L
L
Calin
A
A
Wordsworth
B P
BP
D005192:Family Health; D005260:Female; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009679:Nuclear Family; D011110:Polymorphism, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell