Long-term degeneration in the cochlear nerve and cochlear nucleus of the adult chinchilla following acoustic overstimulation.
Adult chinchillas were exposed once to an octave-band noise, centered at 4 kHz, and allowed to survive for 16 days or for 1, 2, 4, and 8 months. Axonal degeneration was mapped in the cochlear nucleus, using the Nauta-Rasmussen silver method, and related to hair cell damage and to loss of myelinated nerve fibers in the osseous spiral lamina of the cochlea. Axonal degeneration in the dorsal cochlear nucleus had already reached a peak by 16 days and disappeared after 1 month. Meanwhile, myelinated nerve fiber degeneration in the cochlea extended basally, followed 2 weeks to 2 months later by spread of axonal degeneration into the corresponding high-frequency region of the ventral cochlear nucleus. Axonal degeneration occurred early in the low-frequency region of the ventral cochlear nucleus, followed 2-4 weeks later by spread of myelinated fiber degeneration into more apical regions of the cochlea. New degeneration of axons in the cochlear nerve and in the ventral cochlear nucleus continued to occur for up to 8 months after stimulation. These findings imply that plastic changes in the central auditory pathways could play a role in the long-term effects of cochlear damage and acoustic overstimulation, possibly leading to a chronic neurodegenerative condition in the ear and in the brain.
Morest
D K
DK
Department of Anatomy and Center for Neurological Sciences, School of Medicine, University of Connecticut Health Center, Farmington 06030, USA.
Kim
J
J
Potashner
S J
SJ
Bohne
B A
BA
D000161:Acoustic Stimulation / Q000009:adverse effects*; D000818:Animals; D002682:Chinchilla; D003056:Cochlear Nerve / Q000473:pathology*; D017626:Cochlear Nucleus / Q000473:pathology*; D006198:Hair Cells, Auditory / Q000473:pathology; D009410:Nerve Degeneration / Q000209:etiology / Q000473:pathology*; D016622:Silver Staining / Q000379:methods; D013997:Time Factors