title: Spontaneous resolution of myelofibrosis and pancytopenia followed by the development of acute myeloid leukemia with an extramedullary mass.
abstract: OBJECTIVE
  Spontaneous resolution of myelofibrosis is extremely rare. A patient with myelofibrosis and pancytopenia that spontaneously resolved with subsequent development of acute myelomonocytic leukemia and an extramedullary mass of the ovary is described.
  
  
  METHODS
  A 2-year-old girl had severe pancytopenia and myelofibrosis without signs of myeloid metaplasia. The patient was transfused with packed red blood cells and platelets and monitored.
  
  
  RESULTS
  The pancytopenia and myelofibrosis resolved spontaneously within 1 month after initial presentation and her blood counts normalized. The patient developed a chloroma of the ovary and acute myelomonocytic leukemia 13 months later and eventually died from disease.
  
  
  CONCLUSIONS
  This patient initially had acute myelofibrosis which was most likely secondary to occult acute myelomonocytic leukemia. The transfusions may have been a contributing factor in the spontaneous remission.
authors.affiliation: Department of Pediatrics, Hurley Medical Center, Flint, Michigan 48503, USA.
authors.forename: S
authors.initials: S
authors.lastname: Inoue
authors.forename: A
authors.initials: A
authors.lastname: Limsuwan
authors.forename: R
authors.initials: R
authors.lastname: McQueen
mesh_terms: D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000175:diagnosis*; D010051:Ovarian Neoplasms / Q000150:complications*; D010198:Pancytopenia / Q000150:complications*; D055728:Primary Myelofibrosis / Q000150:complications*; D012075:Remission, Spontaneous