title: [Azathioprine ingestion with suicidal intent by an adolescent with chronic juvenile polyarthritis].
abstract: We report on a 13 years 7 months old boy who ingested 650 mg azathioprine in a suicide attempt. His baseline medication was azathioprine and methotrexate for control of juvenile chronic polyarthritis. After the induction of vomiting by ipecacuanha sirup and administration of charcoal (1 g/kg), he was closely followed for haematological, hepatic, and renal side effects. During the following days, no serious adverse events were noted except that the thrombocyte (from 403,000 down to 199,000/microliter) and total leukocyte count decreased moderately (from 12,000 down to 7100/microliter). On the basis of this case report and the available literature, the potential acute toxicity of azathioprine and possible treatment modalities are discussed.
authors.affiliation: Klinik mit Poliklinik für Kinder und Jugendliche, Universität Erlangen-Nürnberg.
authors.forename: C
authors.initials: C
authors.lastname: Krüger
authors.forename: J
authors.initials: J
authors.lastname: Jüngert
authors.forename: S
authors.initials: S
authors.lastname: Schmitt-Grohe
authors.forename: M
authors.initials: M
authors.lastname: Beese
authors.forename: H
authors.initials: H
authors.lastname: Ruder
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000523:psychology*; D001379:Azathioprine / Q000008:administration & dosage / Q000506:poisoning*; D003422:Critical Care; D062787:Drug Overdose / Q000523:psychology* / Q000628:therapy; D005392:First Aid; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000506:poisoning*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D012803:Sick Role; D013406:Suicide, Attempted / Q000523:psychology*
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine
vernacular_title: Azathioprin-Ingestion in suizidaler Absicht bei einem Jugendlichen mit juveniler chronischer Polyarthritis.