Association of HLA class I and class II alleles with myositis in Japanese patients.
OBJECTIVE
To investigate the correlation of HLA class I and class II antigens and alleles with various forms of myositis in Japanese patients.


METHODS
Eighty-four Japanese patients with myositis [22 with polymyositis (PM), 46 with dermatomyositis (DM), 16 with myositis overlapping with other collagen vascular diseases] were typed serologically for HLA-A, B, C antigens. HLA-DRB1, DQA1, and DQB1 alleles were determined by polymerase chain reaction dependent DNA typing methods. Fifty-eight Japanese controls were typed serologically while HLA-DRB1, DQA1, and DQB1 allele typing was carried out in 175, 95, and 104 controls, respectively.


RESULTS
HLA-B7 was higher in patients than controls [20.2 vs 6.9% in controls: p=0.02, odds ratio (OR)=3.4]. The increase of HLA-B7 was largely dependent on the increase in overlap patients (37.5%; p=0.005, OR=8.1). HLA-A24 and B52 were significantly decreased in PM as compared to DM, while CW3 was significantly increased in PM versus DM. DRB1*08 alleles were significantly increased in patients (36.9 vs 20.5% in controls; p=0.004, OR=2.3), especially in PM and DM. DQA1*0501 and DQB1*0301 were significantly decreased in patients [4.8 vs 13.7% in controls; p=0.04, OR=0.32, and 8.3 vs 20.2% in controls; p=0.02, OR=0.36, respectively].


CONCLUSIONS
HLA-class I and class II alleles associated with Japanese patients with myositis may be different from those associated with Caucasian patients.
Furuya
T
T
Institute of Rheumatology, Tokyo Women's Medical College, Japan.
Hakoda
M
M
Higami
K
K
Ueda
H
H
Tsuchiya
N
N
Tokunaga
K
K
Kamatani
N
N
Kashiwazaki
S
S
D000483:Alleles; D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D004247:DNA / Q000032:analysis; D003882:Dermatomyositis / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D006680:HLA Antigens / Q000097:blood; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D017285:Polymyositis / Q000235:genetics* / Q000276:immunology; D044465:White People / Q000235:genetics
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D004247:DNA