title: Hepatocyte growth factor and Met/HGF receptors in patients with gastric adenocarcinoma.
abstract: Overexpression and amplification of Met/HGF receptor has been detected in gastric cancer tissues and cell lines. In this study hepatocyte growth factor (HGF) and Met/HGF receptors were localized in 32 gastric cancer and adjacent normal gastric tissues by the avidin-biotin-peroxidase complex technique. HGF (87.5%) and Met/HGF receptors (68.8%) were demonstrated in gastric cancer tissues. A high positive rate of HGF (87.0%) and Met/ HGF receptors (82.6%) presented in intestinal type gastric cancer. HGF immunoreactivity in gastric cancer tissues was a significant and powerful prognostic indicator (relative risk 15.9; p=0.01). These data suggest that HGF and Met/HGF receptors are involved in the morphogenesis of intestinal type gastric cancer. HGF may have other mechanism that favor gastric cancer spread and independently affect survival.
authors.affiliation: Department of Surgery, Veterans General Hospital-Taipei, Taipei, 11217 Taiwan, R.O.C.
authors.forename: C W
authors.initials: CW
authors.lastname: Wu
authors.forename: A F
authors.initials: AF
authors.lastname: Li
authors.forename: C W
authors.initials: CW
authors.lastname: Chi
authors.forename: W W
authors.initials: WW
authors.lastname: Chung
authors.forename: T Y
authors.initials: TY
authors.lastname: Liu
authors.forename: W Y
authors.initials: WY
authors.lastname: Lui
authors.forename: F K
authors.initials: FK
authors.lastname: P'eng
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D017228:Hepatocyte Growth Factor / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019859:Proto-Oncogene Proteins c-met / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
chemical_list: D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met