[Use of the micronucleus test in the evaluation of cytogenetic state of persons living in the polluted area of the Siberian chemical plant].
We have carried out analysis of the number of blood erythrocytes and lymphocytes with micronuclei in the inhabitants of four settlements located near the place of the accident, which happened at the atomic power station of the Siberian chemical plant (Tomsk-7) on April 6, 1993. In all cases, the people examined showed a considerable increase in the number of cells with micronuclei as compared with the control. We observed the same people for two years and found a gradual decrease in the number of cells with micronuclei. It has been shown in this work, that people born in 1963-1970 have a much higher level of cells with micronuclei, which we tend to regard as a result of the radiation accident at the Siberian chemical plant in 1963. The data we have obtained allow us to conclude that penetration of radionuclides into the human organism in the prenatal and early postnatal periods can lead to the formation of stable clones of erythroid cells with micronuclei and a higher level of erythrocytes with micronuclei, which can remain in the blood for a long time.
Il'inskikh
N N
NN
Siberian Medical University, Tomsk. root@ecogen.tomsk.su
Il'inskikh
E N
EN
Ivanchuk
I I
II
Rogozin
E A
EA
D000293:Adolescent; D000328:Adult; D000396:Air Pollutants, Radioactive / Q000633:toxicity*; D002648:Child; D002869:Chromosome Aberrations; D004912:Erythrocytes / Q000528:radiation effects; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D015162:Micronucleus Tests; D011210:Power Plants; D018788:Radioactive Hazard Release; D011854:Radiochemistry; D012800:Siberia
D000396:Air Pollutants, Radioactive
Ispol'zovanie mikroiadernogo testa dlia otsenki sostoianiia tsitogeneticheskogo apparata u liudeĭ, prozhivaiushchikh v zone vliianiia Sibirskogo khimicheskogo kombinata.