title: Black and white patients response to antidepressant treatment for major depression.
abstract: Differences in response to psychopharmacologic agents according to race has so far primarily focused on investigations related to the response of Asian-American patients to neuroleptics and lithium. In this article, we present evidence which depicts that black patients need lower doses of tricyclic antidepressants (TCAs) than white patients to attain a similar response in the treatment of major depression. Likewise, we also advance that black patients might need lower doses of selective serotonin re-uptake inhibitor antidepressants (SSRIs) than white patients to attain a similar response in the treatment of major depression. Further studies are suggested to confirm these findings.
authors.affiliation: Department of Psychiatry and Behavioral sciences of the University of Texas/Houston Health Science Center, USA.
authors.forename: R V
authors.initials: RV
authors.lastname: Varner
authors.forename: P
authors.initials: P
authors.lastname: Ruiz
authors.forename: D R
authors.initials: DR
authors.lastname: Small
mesh_terms: D015057:1-Naphthylamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000627:therapeutic use; D000328:Adult; D000553:Ambulatory Care; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D044383:Black People / Q000235:genetics*; D001835:Body Weight; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D020280:Sertraline; D012737:Sex Factors; D016896:Treatment Outcome; D044465:White People / Q000235:genetics*
chemical_list: D015057:1-Naphthylamine; D000929:Antidepressive Agents, Tricyclic; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline