title: The role of E-proteins in B- and T-lymphocyte development.
abstract: Department of lymphocytes from hematopoietic stem cells is controlled, in part, by the activity of transcriptional regulatory proteins. In particular, one class of helix-loop-helix proteins, termed E-proteins, have been implicated in the regulation of gene expression during B-cell development. Recent analysis of gene-targeted mice has allowed a direct assessment of the functional roles of several E-protein family members in hematopoiesis. In this review we describe the defects in B- and T-lymphocyte development in mice carrying targeted mutations in the E-protein genes and discuss our current understanding of the role of these proteins in lymphoid development.
authors.affiliation: Department of Biology, University of California, San Diego, La Jolla 92093, USA.
authors.forename: G
authors.initials: G
authors.lastname: Bain
authors.forename: C
authors.initials: C
authors.lastname: Murre
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins / Q000502:physiology*; D005544:Forecasting; D018257:Helix-Loop-Helix Motifs / Q000502:physiology*; D006801:Humans; D013601:T-Lymphocytes / Q000166:cytology*; D051820:TCF Transcription Factors; D015534:Trans-Activators / Q000502:physiology*; D058125:Transcription Factor 7-Like 1 Protein; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D051820:TCF Transcription Factors; D015534:Trans-Activators; D058125:Transcription Factor 7-Like 1 Protein; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors; C544912:TCF7L1 protein, human; C544894:TCF7L2 protein, human; C544913:Tcf7l1 protein, mouse; C544895:Tcf7l2 protein, mouse; C073366:TCF12 protein, human