title: Aminoaciduria and glycosuria following severe childhood lead poisoning.
abstract: To determine the incidence of renal functional abnormalities after lead poisoning, we evaluated the parameters of renal tubular function in 134 children and young adults, 8-13 years after chelation therapy for severe lead poisoning. There was no evidence of hypertension or reduced kidney function as assessed by serum creatinine (Cr) concentrations. Urinary alpha-amino nitrogen (Uaan) concentrations were significantly increased compared with 19 healthy age-matched controls. Ninety-four children (70%) had aminoaciduria (Uaan/Cr >0.23). Urinary glucose excretion was also significantly higher than that of 2 historical controls. Thirty-two children (24%) had glycosuria (>125 mg/24 h). Fractional excretion of phosphate was normal in all children. We conclude that a partial Fanconi syndrome can persist up to 13 years after childhood lead poisoning.
authors.affiliation: Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132, USA.
authors.forename: M
authors.initials: M
authors.lastname: Loghman-Adham
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005198:Fanconi Syndrome / Q000209:etiology; D006029:Glycosuria / Q000209:etiology*; D006801:Humans; D007223:Infant; D007855:Lead Poisoning / Q000150:complications*; D000608:Renal Aminoacidurias / Q000209:etiology*