[The cardioprotective action of preparations of biotechnological cytochrome c in acute myocardial ischemia].
The cardioprotective effect of cytochrome c preparations was evaluated according to the test for restriction of the size of the myocardial infarct and the effect on the course of acute myocardial ischemia in acute experiments on dogs. Cytochrome c of biotechnological and animal origin and hemtetradecapeptide caused a marked decrease in the size of the myocardial necrosis in experiments on rats: from 68 +/- 4.3% in the control to 32 +/- 3.4, 46 +/- 8.3 and 44 +/- 4.7%, respectively. In dog experiments the cytochrome c agents reduced the intensity of dp/dt decline and decreased the collateral coronary blood flow in acute myocardial ischemic. They produced a beneficial effect on heart bioenergetics, namely, reduced the lactate level in blood flowing from the zone of the ischemia and glucose consumption by the ischemic myocardium. The cardioprotective effect of biotechnological cytochrome c hemtetradecapeptide was practically identical to the effect of the enzyme of animal origin.
Gatsura
V V
VV
Research Center of Biologically Active Agents, Moscow Region, Russia.
Sernov
L N
LN
Davidov
E R
ER
D000208:Acute Disease; D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003580:Cytochromes / Q000627:therapeutic use*; D045348:Cytochromes f; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D010446:Peptide Fragments / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D002317:Cardiovascular Agents; D003580:Cytochromes; D010446:Peptide Fragments; D045348:Cytochromes f
Kardioprotektornoe deĭstvie preparatov biotekhnologicheskogo tsitokhroma c pri ostroĭ ishemii miokarda.