Intragenic recombinations in rotaviruses.
In this paper, evidence for intragenic recombination in the VP7 gene between rotavirus strains bearing different serotypes is demonstrated for the first time. Intragenic recombination may be one of the escaping mechanisms from the host immune system for rotavirus. This process involves exchanging antigenic regions, thus questioning the use of multivalent vaccines for the prevention of rotavirus infection.
Suzuki
Y
Y
Department of Microbiology, Akita University School of Medicine, Japan.
Gojobori
T
T
Nakagomi
O
O
D000956:Antigens, Viral; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D005814:Genes, Viral / Q000235:genetics; D010802:Phylogeny; D011995:Recombination, Genetic; D012401:Rotavirus / Q000235:genetics*; D016415:Sequence Alignment; D015678:Viral Structural Proteins / Q000235:genetics
D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus; D015678:Viral Structural Proteins