title: Endotoxin modulates arachidonic acid-induced glycogenolysis in the perfused rat liver.
abstract: Effects of endotoxin on arachidonic acid (AA)-induced hepatic glycogenolysis were examined in perfused rat liver. In normal rat liver, infusion of AA increased oxygen consumption and glucose production concurrently. In rats injected with lipopolysaccharide (LPS) 6 h before, AA increased glucose production but suppressed oxygen consumption. The changes in LPS-injected rat were abolished by a thromboxane (Tx) A2 receptor antagonist. The release of Tx B2 by AA increased after LPS-injection. These results suggest that priming of hepatic macrophage by endotoxin in vivo enhances Tx synthesis, resulting in modulating hepatic glycogenolysis.
authors.affiliation: Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Moriyama
authors.forename: M
authors.initials: M
authors.lastname: Nishisako
authors.forename: Y
authors.initials: Y
authors.lastname: Kannan
authors.forename: M
authors.initials: M
authors.lastname: Shiota
authors.forename: T
authors.initials: T
authors.lastname: Sugano
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D017482:Receptors, Thromboxane / Q000037:antagonists & inhibitors
chemical_list: D008070:Lipopolysaccharides; D008112:Liver Glycogen; D017482:Receptors, Thromboxane; D016718:Arachidonic Acid