title: Photodynamic therapy and the treatment of head and neck cancers.
abstract: Photodynamic therapy is an effective curative treatment for early carcinomas of the head and neck and may be of benefit as an adjuvant intraoperative therapy to increase cure rates of large head and neck tumors. Eighty-seven patients with neoplastic diseases of the larynx, oral cavity, pharynx, and skin have been treated with photodynamic therapy (PDT) with follow-up to 66 months. Patients with carcinoma-in-situ and T1 carcinomas obtained a complete response after one PDT treatment. All but two have remained free of disease. Ten patients with massive neck recurrences of squamous cell carcinomas were treated with intraoperative adjuvant PDT following tumor resection. Only three developed recurrence with 40-month follow-up, but only one recurrence was in the field of surgery and PDT.
authors.affiliation: Photodynamic Therapy, Minneapolis Ear, Nose and Throat Clinic, Minnesota, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Biel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001128:Argon; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use*; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006414:Hematoporphyrin Photoradiation; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D010212:Papilloma / Q000188:drug therapy; D019233:Retreatment; D012514:Sarcoma, Kaposi / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D001128:Argon; D017323:Dihematoporphyrin Ether