Immediate reaction to roxithromycin and prick test cross-sensitization to erythromycin and clarithromycin.
Allergic reactions to macrolides appear to be very rare. Only a few cases of fixed drug eruption or urticaria due to the administration of erythromycin have been reported. Cross-reaction between the different macrolides have not yet been published. We report a case of a 31-year-old female patient who developed generalized urticaria and tachycardia shortly after administration of roxithromycin (Rulid). Immediate-type hypersensitivity was confirmed by positive prick test reactions to roxithromycin and the chemically closely related macrolides erythromycin and clarithromycin.
Kruppa
A
A
Department of Dermatology, University of Cologne, Germany.
Scharffetter-Kochanek
K
K
Krieg
T
T
Hunzelmann
N
N
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000737:chemistry; D017291:Clarithromycin / Q000009:adverse effects* / Q000737:chemistry; D003429:Cross Reactions; D004917:Erythromycin / Q000009:adverse effects* / Q000737:chemistry; D005260:Female; D006801:Humans; D007428:Intradermal Tests; D015575:Roxithromycin / Q000009:adverse effects* / Q000737:chemistry; D014581:Urticaria / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D015575:Roxithromycin; D004917:Erythromycin; D017291:Clarithromycin