title: Treatment with human growth hormone in patients with Prader-Labhart-Willi syndrome reduces body fat and increases muscle mass and physical performance.
abstract: Twelve children with documented Prader-Labhart-Willi syndrome were treated with human growth hormone (24 U/m2/week) during 1 year. The children were divided into three groups: group 1: overweight and prepubertal (n=6, age 3.8-7.0 years); group 2: underweight and prepubertal (n=3, age 0.6-4.1 years); group 3: pubertal (n=3, age 9.2-14.6 years). In group 1, height increased from -1.7 SD to -0.6 SD, while weight decreased from 1.1 SD to 0.4 SD, with a dramatic drop in weight for height from 3.8 SD to 1.2 SD. Hand length increased from -1.5 SD to -0.4 SD and foot length from -2.5 SD to -1.4 SD. Body fat, measured by dual X-ray energy absorptiometry, dropped by a third, whereas muscle mass increased by a fourth. Physical capability (Wingate test) improved considerably. The children were reported to be much more active and capable. In group 2, similar changes were seen, but weight for height increased, probably because muscle mass increase exceeded fat mass decrease. Changes in group 3 were similar as in group 1, even though far less distinct.
  
  
  CONCLUSIONS
  Growth hormone treatment in Prader-Labhart-Willi syndrome led to dramatic changes: distinct increase in growth velocity, height and muscle mass, as well as an improvement in physical performance. Fat mass and weight for height decreased in the initially overweight children, and weight for height increased in underweight children.
authors.affiliation: Centre for Adolescent Medicine and Foundation Growth Puberty Adolescence, Zurich, Switzerland. growth@imi.ch
authors.forename: U
authors.initials: U
authors.lastname: Eiholzer
authors.forename: R
authors.initials: R
authors.lastname: Gisin
authors.forename: C
authors.initials: C
authors.lastname: Weinmann
authors.forename: S
authors.initials: S
authors.lastname: Kriemler
authors.forename: H
authors.initials: H
authors.lastname: Steinert
authors.forename: T
authors.initials: T
authors.lastname: Torresani
authors.forename: M
authors.initials: M
authors.lastname: Zachmann
authors.forename: A
authors.initials: A
authors.lastname: Prader
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects; D000293:Adolescent; D000886:Anthropometry; D001823:Body Composition; D002648:Child; D002675:Child, Preschool; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects; D005082:Physical Exertion; D011218:Prader-Willi Syndrome / Q000188:drug therapy*
chemical_list: D019382:Human Growth Hormone