[Azathioprine ingestion with suicidal intent by an adolescent with chronic juvenile polyarthritis].
We report on a 13 years 7 months old boy who ingested 650 mg azathioprine in a suicide attempt. His baseline medication was azathioprine and methotrexate for control of juvenile chronic polyarthritis. After the induction of vomiting by ipecacuanha sirup and administration of charcoal (1 g/kg), he was closely followed for haematological, hepatic, and renal side effects. During the following days, no serious adverse events were noted except that the thrombocyte (from 403,000 down to 199,000/microliter) and total leukocyte count decreased moderately (from 12,000 down to 7100/microliter). On the basis of this case report and the available literature, the potential acute toxicity of azathioprine and possible treatment modalities are discussed.
Krüger
C
C
Klinik mit Poliklinik für Kinder und Jugendliche, Universität Erlangen-Nürnberg.
Jüngert
J
J
Schmitt-Grohe
S
S
Beese
M
M
Ruder
H
H
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000523:psychology*; D001379:Azathioprine / Q000008:administration & dosage / Q000506:poisoning*; D003422:Critical Care; D062787:Drug Overdose / Q000523:psychology* / Q000628:therapy; D005392:First Aid; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000506:poisoning*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D012803:Sick Role; D013406:Suicide, Attempted / Q000523:psychology*
D007166:Immunosuppressive Agents; D001379:Azathioprine
Azathioprin-Ingestion in suizidaler Absicht bei einem Jugendlichen mit juveniler chronischer Polyarthritis.