title: Effect of copper supplementation on the evidence of developmental orthopaedic disease in pasture-fed New Zealand Thoroughbreds.
abstract: The effect of copper status on the evidence of bone and cartilage lesions was investigated in 21 Thoroughbred foals. The foals and their dams were grazed on pasture containing 4.4-8.6 mg Cu/kg dry matter (DM). Four treatment groups were created by randomly allocating mares and their foals to either copper supplemented (0.5 mg Cu/kg liveweight (LW)/day), or control (pasture only) groups. This experimental design allowed the effect of copper supplementation of mare and foal to be examined independently. Parameters of bone and cartilage development were assessed in the foals both in vivo, and at post mortem at approximately age 150 days. Mare copper supplementation significantly (P<0.01) decreased radiographic indices of physitis in the distal third metatarsal bone of the foals at 150 days, and the prevalence of articular cartilage lesions (P<0.05). Articular cartilage lesions were minor in all foals, with no evidence of clinical developmental orthopaedic disease (DOD) in vivo, with the exception of minor radiographic changes assessed at post mortem. Copper supplementation of the foal had no effect on any of the bone and cartilage parameters. Copper supplementation of the mares did not abolish DOD in the growing foals, emphasising the probable multifactorial nature of this condition. However, mare supplementation may be a useful treatment regime on a farm where the incidence and severity of DOD are of concern.
authors.affiliation: Department of Veterinary Clinical Science, Massey University, Palmerston North, New Zealand.
authors.forename: S G
authors.initials: SG
authors.lastname: Pearce
authors.forename: E C
authors.initials: EC
authors.lastname: Firth
authors.forename: N D
authors.initials: ND
authors.lastname: Grace
authors.forename: P F
authors.initials: PF
authors.lastname: Fennessy
mesh_terms: D000704:Analysis of Variance; D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D001706:Biopsy / Q000662:veterinary; D001846:Bone Development / Q000187:drug effects / Q000502:physiology; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000517:prevention & control / Q000662:veterinary*; D002357:Cartilage Diseases / Q000000981:diagnostic imaging / Q000517:prevention & control / Q000662:veterinary*; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000503:physiopathology; D003300:Copper / Q000172:deficiency / Q000378:metabolism*; D019327:Copper Sulfate / Q000008:administration & dosage* / Q000494:pharmacology; D019587:Dietary Supplements; D005121:Extremities / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006734:Horse Diseases / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology*; D006736:Horses; D008297:Male; D009520:New Zealand; D011859:Radiography; D011897:Random Allocation
chemical_list: D003300:Copper; D019327:Copper Sulfate