Guidelines for antiretroviral therapy for HIV infection. Canadian HIV Trials Network Antiretroviral Working Group.
OBJECTIVE
To develop guidelines for health care providers and their HIV-positive patients on the clinical use of antiretroviral agents for HIV infection.


METHODS
Recommendations published in 1996 by an international panel.


RESULTS
Improvement in clinical outcomes or in surrogate markers of disease activity. EVIDENCE AND VALUES: The Canadian HIV Trials Network held a workshop on Oct. 19-20, 1996, to develop Canadian guidelines that incorporate information from recent basic and clinical research.


CONCLUSIONS
Recommendations for the use of antiretroviral drugs in HIV infection are provided for initial therapy, continuing therapy, primary infection, vertical transmission, pediatric therapy and postexposure prophylaxis.


RESULTS
The guidelines are based on consensus of the participants attending the workshop: Canadian investigators, clinicians and invited representatives from the community, government and the pharmaceutical industry. They are subject to review and updating as new information on clinical benefits is published.


BACKGROUND
The workshop was organized by the National Centre of the Canadian HIV Trials Network. Unrestricted educational grants were provided by 8 pharmaceutical companies. Additional support was provided from the National AIDS Strategy of Health Canada.
Rachlis
A R
AR
St. Paul's Hospital, Vancouver BC.
Zarowny
D P
DP
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002170:Canada; D002648:Child; D016903:Drug Monitoring / Q000379:methods; D004352:Drug Resistance, Microbial; D015658:HIV Infections / Q000188:drug therapy* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D018579:Patient Selection; D019562:Viral Load
D019380:Anti-HIV Agents