[Significance of family assessment and biological markers in the prevention of arterial hypertension].
OBJECTIVE
To verify the predictability of the appearance of hypertension through the clinical history and biological markers.


METHODS
Consisted of 300 Portuguese Caucasian individuals, M = 130 and F = 170, between the ages 18 and 85, including 90 pregnant women.


METHODS
Blood pressure was measured in every individual, and questions were made concerning personal and familiar hypertensive background. The serum renin activity, the active renin, serum endoxin, and the urinary aldosteron, free dopamine, c--AMP, and noradrenalin were checked. The analysis of the results was carried ou using the Student's T Test and de chi(2) method.


CONCLUSIONS
Hypertensive parents lead to the development of hypertension on their descendants; the averages of diastolic blood pressure in normotensive individuals are higher when parents are hypertensive, compared with normotensive, seeming that a possible genetic factor may be implied in the involvement of the vessels. Normotensive young masculine adultshave higher average systolic blood pressure when their fathers are hypertensive, than those whose fathers have normal blood pressure levels; as far as young women are concerned, we verified that the mother's genetic influence seems to be relevant in the appearance of higher blood pressure levels in their daughters during pregnancy, contributing to think hat man and women may have genetically different factors to determine blood pressure levels. We also verified that young adults with normal levels of blood pressure, whose parents suffer from high blood pressure, present significantly higher levels of serum renin activity than a similar group of young adults whose parents have normal blood pressure. We concluded that the family history and the measuring of the blood pressure even at young adults may contribute for the forecasting of high blood pressure, as is the evaluation of biological parameters, particularly in those who have family history of hypertension. Serum renin activity may be a possible biological marker for the forecast of the future development of high blood pressure.
Silva
A P
AP
Laboratório de Genética, Faculdade de Medicina de Lisboa.
Neves
J
J
Bicho
M C
MC
Bicho
M P
MP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
D015415:Biomarkers
Importância da avaliação familiar e marcadores biológicos na previsão da hipertensão arterial.