title: [Elaboration of live measles vaccine technology on human embryo lung diploid cell culture L-68].
abstract: Measles predominates among childhood droplet infections in many countries. Immunization of all human beings sensitive to this infection is the only radical measure in controlling measles. The quality of a vaccine is primarily determined by the properties of the virus strains and cell cultures and technology of production. Now live measles vaccine is produced in or country on the basis of fibroblasts from Japanese quail embryo. The production of live measles vaccine in the primary cell cultures has a number of drawbacks caused by the nonstandard pattern of the substrate and the probability of contamination. The use the certified human diploid cells deposited in liquid nitrogen in sufficient quantities is promising. The authors have elaborated a new technology of live measles vaccine production by using the Leningrad-16 virus strain on the basis of attested L-68 diploid cell culture from the human fetal lung. Experimental batches of vaccine were obtained and attested in accordance with the present requirements for immunobiological products.
authors.forename: E A
authors.initials: EA
authors.lastname: Nechaeva
authors.forename: T D
authors.initials: TD
authors.lastname: Kolokol'tsova
authors.forename: I V
authors.initials: IV
authors.lastname: Kits
authors.forename: N V
authors.initials: NV
authors.lastname: Zhilina
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Sen'kina
authors.forename: S V
authors.initials: SV
authors.lastname: Usova
authors.forename: N D
authors.initials: ND
authors.lastname: Iurchenko
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Azaev
authors.forename: A A
authors.initials: AA
authors.lastname: Tsareva
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002478:Cells, Cultured / Q000821:virology; D004622:Embryo, Mammalian / Q000166:cytology / Q000187:drug effects / Q000821:virology*; D006168:Guinea Pigs; D006801:Humans; D008168:Lung; D008457:Measles / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D008458:Measles Vaccine / Q000096:biosynthesis* / Q000627:therapeutic use; D008459:Measles virus / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine
vernacular_title: Razrabotka tekhnologii proizvodstva zhivoĭ korevoĭ vaktsiny na osnove kul'tury kletok émbriona cheloveka L-68.