title: Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora. II. Structural studies.
abstract: The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.
authors.affiliation: Faculty of Agriculture, Tamagawa University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hori
authors.forename: Y
authors.initials: Y
authors.lastname: Igarashi
authors.forename: T
authors.initials: T
authors.lastname: Kajiura
authors.forename: T
authors.initials: T
authors.lastname: Furumai
authors.forename: K
authors.initials: K
authors.lastname: Higashi
authors.forename: T
authors.initials: T
authors.lastname: Ishiyama
authors.forename: M
authors.initials: M
authors.lastname: Uramota
authors.forename: Y
authors.initials: Y
authors.lastname: Uehara
authors.forename: T
authors.initials: T
authors.lastname: Oki
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D015398:Signal Transduction / Q000187:drug effects*; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D004791:Enzyme Inhibitors; D011505:Protein-Tyrosine Kinases