[Cough variant asthma among patients with chronic persistent cough and its clinical outcome].
Thirty-nine patients with chronic persistent cough continuing more than eight weeks were examined regarding to their airway responsiveness to methacholine challenge using the Astograph (TCK-6100H, Chest Corp. Japan). Of these, twenty-three individuals (59%) had airway hyperresponsiveness, leading to diagnose as having cough variant asthma (CVA). Patients with CVA had a higher percentage of eosinophils in peripheral blood and a lower forced expiratory volume in one second than those in non-CVA group. Furthermore, four patients (17%) developed the classic signs and symptoms of asthma, whereas 7 cases (30%) resolved their cough without further treatment and 12 cases (52%) continued to have CVA. These data suggested that a significant proportion of patients with chronic persistent cough had CVA and some of them may develop to classic wheezing asthma.
Iwanaga
T
T
Department of Pulmonary Medicine, National Minami-Fukuoka Chest Hospital.
Inuzuka
S
S
Takahashi
N
N
Kishikawa
R
R
Yokota
K
K
Ikeda
T
T
Hirose
T
T
Tsurutani
H
H
Nishima
S
S
D001249:Asthma / Q000175:diagnosis*; D016535:Bronchial Hyperreactivity; D002908:Chronic Disease; D003371:Cough / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged
D016210:Methacholine Chloride