title: Postcoital antifertility activity of aminoalcohols.
abstract: Previously, postcoital antifertility effects of a number of aminoalcohols, including 2-(isopropylamino)-ethanol, have been demonstrated in rodents. In this experiment, we compared the antifertility activity of 2-(isopropylamino)-ethanol to the following analogs: hydroxyethylpiperidine, hydroxyethylpiridine, hydroxyethylpirrolidine, and hydroxyethylpirrolidone. Female rats were gavaged on Days 0 through 5 of gestation with 0.7 mmol/kg/d of these substances. Only 2-(isopropylamino)-ethanol and hydroxyethylpirrolidine showed a strong antifertility activity: females treated with 2-(isopropylamino)-ethanol had no signs of implantation, whereas those treated with hydroxyethylpirrolidine had 100% early resorptions. Treatments with these two substances during the periimplantation period (Days 4 and 5) produced 100% early resorptions. Histologic examination of the implantation sites showed signs of embryonic degeneration starting from Day 6.5 of gestation. The flushing of the uteri of females treated with 2-(isopropylamino)-ethanol on Days 0 through 3 post coitum showed 78% of the embryos at the stage of 1 to 3 blastomeres, whereas the embryos of females treated during the same period with hydroxyethylpirrolidine were normal blastocysts. Therefore, 2-(isopropylamino)-ethanol and hydroxyethylpirrolidine are able to kill embryos during the early implantation stages, whereas 2-(isopropylamino)-ethanol is also able to stop the development of preimplantation embryos.
authors.affiliation: Department of Biology, University of Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Menegola
authors.forename: M L
authors.initials: ML
authors.lastname: Broccia
authors.forename: M
authors.initials: M
authors.lastname: Prati
authors.forename: E
authors.initials: E
authors.lastname: Giavini
mesh_terms: D000605:Amino Alcohols / Q000494:pharmacology*; D000818:Animals; D003281:Contraceptives, Postcoital / Q000737:chemistry / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004983:Ethanolamines / Q000737:chemistry*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000605:Amino Alcohols; D003281:Contraceptives, Postcoital; D004983:Ethanolamines; C008203:2-isopropylaminoethanol