title: Susceptibilities of Legionella spp. to newer antimicrobials in vitro.
abstract: The in vitro activities of 13 antimicrobial agents against 30 strains of Legionella spp. were determined. Rifapentine, rifampin, and clarithromycin were the most potent agents (MICs at which 90% of isolates are inhibited [MIC90s], < or = 0.008 microgram/ml). The ketolide HMR 3647 and the fluoroquinolones levofloxacin and BAY 12-8039 (MIC90s, 0.03 to 0.06 microgram/ml) were more active than erythromycin A or roxithromycin. The MIC90s of dalfopristin-quinupristin and linezolid were 0.5 and 8 micrograms/ml, respectively. Based on class characteristics and in vitro activities, several of these agents may have potential roles in the treatment of Legionella infections.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
authors.forename: T
authors.initials: T
authors.lastname: Schülin
authors.forename: C B
authors.initials: CB
authors.lastname: Wennersten
authors.forename: M J
authors.initials: MJ
authors.lastname: Ferraro
authors.forename: R C
authors.initials: RC
authors.lastname: Moellering
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds; D024841:Fluoroquinolones; D006801:Humans; D048628:Ketolides; D007875:Legionella / Q000187:drug effects*; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D011804:Quinolines; D015363:Quinolones / Q000494:pharmacology; D012293:Rifampin / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D048628:Ketolides; D018942:Macrolides; D011804:Quinolines; D015363:Quinolones; C106791:telithromycin; D000077266:Moxifloxacin; D012293:Rifampin; C018421:rifapentine