Myelodysplastic syndromes (MDS): prognostic factors and scoring systems.
OBJECTIVE
To evaluate the score systems of Cassano and Sanz and suggest a new one.


METHODS
Case series.


METHODS
Teaching hospitals: EPM UNIFESP and Faculdade de Medicina de Botucatu.


METHODS
59 patients diagnosed from 1979 to 1992.


METHODS
Evaluation of clinical-laboratorial data.


METHODS
Statistical comparison, uni and multivariate analysis and actuarial survival curves.


RESULTS
Cassano's system divided the patients into high and low risk (p = 0.0966) while Sanz's gave high, intermediate and low risk (p = 0.0108). The univariate analysis showed hemoglobin, WBC count, E/M ratio, liver size and blast percentage in BM as statistically significant. The multivariate analysis showed blast percentage in BM (p = 0.004) and Hb (p = 0.050) as significant. Our system, considering the multivariate analysis data, divided the patients into high, intermediate and low risk (p = 0.0038).


CONCLUSIONS
Sanz's system was more functional than Cassano's, while ours showed predictive survival value and ease of use in clinical practice.
Souto
E X
EX
Department of Hematology, Faculdade de Medicina de Botucatu, Escola Paulista de Medicina/UNIFESP, São Paulo, Brazil.
Chauffaile
M de L
Mde L
Moncau
J E
JE
Niero-Melo
L
L
Braga
G W
GW
Silva
M R
MR
Kerbauy
J
J
D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis