The phosphorylated isoform of microtubule associated protein 1B (MAP1B) is expressed in the visual system of the tench (Tinca tinca, L) during optic nerve regeneration.
By using Western blot analysis and immunohistochemistry we have demonstrated that microtubule associated protein 1B (MAP1B)-phos is present in growing and regenerating axons of retinal ganglion cells of fish (Tinca tinca, L). We have found that the levels of MAP1B-phos substantially increase in regenerating optic nerves. Our observations suggest that MAP1 B-phos plays an important role in regeneration processes in the central nervous system (CNS) of the fish. These results are compared in the present paper with that found in the regenerating peripheral nervous system (PNS) of mammals.
Vecino
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E
Departamento de Biología Celular y Ciencias Morfológicas, Facultad de Medicina, Universidad del País Vasco, Leioa, Vizcaya, Spain. gcpvecoe@lg.ehu.es
Ulloa
L
L
Avila
J
J
D000818:Animals; D003530:Cyprinidae / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis*; D009416:Nerve Regeneration; D009900:Optic Nerve / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D020033:Protein Isoforms / Q000096:biosynthesis; D014795:Visual Pathways / Q000378:metabolism* / Q000502:physiology
D008869:Microtubule-Associated Proteins; D020033:Protein Isoforms; C085284:microtubule-associated protein 1B