Effect of taurine on toxicity of copper in rats.
An attempt was made to study the effect of taurine on the toxicity of copper in male Wistar rats. The rats were divided into eight groups and fed different diets with or without supplement of 5% taurine and 150-600 ppm copper for 2 months. It was found that the levels of copper and malondialdehyde (MDA) in the liver, and the activities of aspartate transaminase (AST) and alanine transaminase (ALT) in the plasma of rats were increased with the increasing dose of copper. However, the levels of copper and MDA, and the enzyme activities of AST and ALT in the rats fed with supplement of taurine were significantly lower than in the rats fed without supplement of taurine. The level of copper in the faeces of rats treated with taurine and copper was higher than that of rats treated with copper alone. It indicated that taurine might play a role in reducing the toxic effect of copper in rats.
Hwang
D F
DF
Department of Marine Food Science, National Taiwan Ocean University, Keelung, ROC.
Wang
L C
LC
Cheng
H M
HM
D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D000821:Animal Feed; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D003300:Copper / Q000378:metabolism / Q000633:toxicity*; D005243:Feces / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000008:administration & dosage / Q000494:pharmacology*
D013654:Taurine; D008315:Malondialdehyde; D003300:Copper; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase