title: Short-term hemodynamic evaluation of circumferential mitral annuloplasty for correction of mitral valve regurgitation in dogs.
abstract: OBJECTIVE
  To determine the short-term hemodynamic effects associated with circumferential mitral annuloplasty (CMA) in dogs with mitral regurgitation.
  
  
  METHODS
  Prospective experimental study. Animals-Seven healthy adult mongrel dogs.
  
  
  METHODS
  Mitral regurgitation was surgically induced, and annular dilation occurred. Echocardiography and cardiac catheterization were used to determine forward ejection fraction (FEF), regurgitant fraction (RF), pulmonary capillary wedge pressure (PCWP), and annular diameter before and immediately after CMA in five dogs. FEF and RF were also evaluated 7 days after annuloplasty.
  
  
  RESULTS
  Mean annular diameter and PCWP were significantly reduced immediately after CMA. Significant increases in FEF of 19% and 22% were shown immediately and 7 days after CMA. Significant reductions in RF of 19% and 22% were also shown immediately and 7 days after annuloplasty.
  
  
  CONCLUSIONS
  Sustained hemodynamic benefits and a reduction in annular diameter were achieved by CMA in a canine model of mitral regurgitation.
  
  
  CONCLUSIONS
  CMA may be a suitable treatment for heart failure because of mitral regurgitation when early signs of cardiovascular decompensation persist despite appropriate medical management.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Kerstetter
authors.forename: J E
authors.initials: JE
authors.lastname: Sackman
authors.forename: J W
authors.initials: JW
authors.lastname: Buchanan
authors.forename: J M
authors.initials: JM
authors.lastname: Bright
authors.forename: D J
authors.initials: DJ
authors.lastname: Krahwinkel
authors.forename: R M
authors.initials: RM
authors.lastname: Bright
authors.forename: D
authors.initials: D
authors.lastname: Lorinson
authors.forename: R E
authors.initials: RE
authors.lastname: Gompf
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000503:physiopathology / Q000601:surgery*; D004285:Dogs; D004452:Echocardiography / Q000662:veterinary; D006439:Hemodynamics; D008943:Mitral Valve / Q000502:physiology / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume; D013536:Suture Techniques / Q000662:veterinary