[The effect of changes in nutritional status induced by age on oxidative liver metabolism].
BACKGROUND
The hepatic oxidative metabolism is essential for the biotransformation of a large number substances, among which are found many drugs which are commonly used in clinical practice. The nutritional status of individuals has been shown to be of influence on this function. Aging produces a deterioration of the hepatic oxidative metabolism, without the cause for this situation having been clarified. Also, aging modifies the body composition of the individuals. The objective of this study is to evaluate whether the modifications which arise in the nutritive status due to age, can alter the hepatic oxidative capacity.


METHODS
165 elderly people of both sexes were studied, with an average age of 82 years, and 24 young people, with an average age of 29 years. All participants were subjected to a clinical questionnaire, along with an evaluation of anthropometric, biochemical, and immunological nutritive parameters. The study of the oxidative metabolism was conducted by evaluating the kinetics of antipyrine.


RESULTS
The elderly people showed a decrease in the antipyrine clearance rate (Ap Cl) (P < 0.001), and a lengthening of their life-span (P < 0.05) with respect to the younger people. There was a significant correlation in the elderly people, between the Ap Cl and age, weight, size, the distribution volume, and the muscular area of the arm. A multiple regression analysis showed a predictive value which was independent for age, the AST, the lymphocytes, and size.


CONCLUSIONS
Elderly people have a marked depression of the hepatic oxidative metabolism. The factors which participate in their nutritional situation, are of influence on this function. It is necessary to keep all the above in mind when it comes to prescribing drugs which require this type of biotransformation, in order to avoid adverse effects or drug interactions.
Jorquera Plaza
F
F
Sección de Digestivo del Complejo Hospitalario del Insalud de León, España.
Cuevas González
M J
MJ
Pozuelo Manchón
M
M
San Segundo
D
D
Almar Galiana
M
M
González Sastre
M
M
González-Gallego
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status / Q000502:physiology*; D010084:Oxidation-Reduction; D012727:Sex Characteristics
Influencia de los cambios en el estado nutritivo inducidos por la edad sobre el metabolismo oxidativo hepático.