Chromosome breaks and sister chromatid exchange as predictors of second cancers in Hodgkin's disease.
Hodgkin's disease (HD) survivors face an increased risk of developing second cancers. We evaluated baseline cytogenetic biomarkers, sister chromatid exchange (SCE) and chromosome breaks [spontaneous (SCB) and bleomycin-induced (BIB)], as predictors of second cancer risk in a cohort of 105 adult HD patients. During follow-up, seven second cancers occurred. SCBs and BIBs showed no association with risk of second primaries. Multivariate Cox regression revealed that high levels of SCEs (relative risk (RR)=11.3, p=0.02) and age (RR=1.08, p=0.02) predicted second cancer risk. Histology, stage, and treatment were not associated with elevated risk. In conclusion, baseline SCE frequencies may be a useful biomarker for identifying HD patients at increased risk of developing second cancers. These results need to be verified in a larger cohort with a longer follow-up time.
Strom
S S
SS
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Gu
Y
Y
Sigurdson
A J
AJ
Bailey
N M
NM
Amos
C I
CI
Spitz
M R
MR
Rodriguez
M A
MA
Liang
J C
JC
D000293:Adolescent; D000328:Adult; D000368:Aged; D019457:Chromosome Breakage; D002877:Chromosomes, Human; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000235:genetics* / Q000473:pathology*; D011237:Predictive Value of Tests; D012854:Sister Chromatid Exchange