title: Non-O157:H7 Stx2-producing Escherichia coli strains associated with sporadic cases of hemolytic-uremic syndrome in adults.
abstract: From August 1996 to May 1997, six verotoxin-producing Escherichia coli (VTEC) strains were isolated from stool specimens of adults suffering from hemolytic-uremic syndrome (HUS). All the isolates were stx2 positive and belonged to different serotypes: O6:H4, O91:H10, O91:H21, O rough:H16, OX3:H-, and O nontypeable: H-. The enterohemolysin (Ehly)-encoding genes were detected in two isolates, and none of the isolates harbors the intimin (Eae)-encoding gene. These findings suggest that stx2-positive non-O157:H7 VTEC is a major cause of HUS in adults and that several sources of pathogens are responsible for local endemic infections.
authors.affiliation: Laboratoire de Bactériologie, Faculté de Médecine-Pharmacie, Université d'Auvergne-Clermont-1, Clermont-Ferrand, France.
authors.forename: R
authors.initials: R
authors.lastname: Bonnet
authors.forename: B
authors.initials: B
authors.lastname: Souweine
authors.forename: G
authors.initials: G
authors.lastname: Gauthier
authors.forename: C
authors.initials: C
authors.lastname: Rich
authors.forename: V
authors.initials: V
authors.lastname: Livrelli
authors.forename: J
authors.initials: J
authors.lastname: Sirot
authors.forename: B
authors.initials: B
authors.lastname: Joly
authors.forename: C
authors.initials: C
authors.lastname: Forestier
mesh_terms: D018829:Adhesins, Bacterial; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000235:genetics; D015373:Bacterial Typing Techniques; D002352:Carrier Proteins; D004269:DNA, Bacterial / Q000032:analysis; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology*; D029968:Escherichia coli Proteins; D005243:Feces / Q000382:microbiology; D006460:Hemolysin Proteins / Q000235:genetics; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012703:Serotyping; D022622:Shiga Toxin 1; D014774:Virulence
chemical_list: D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001427:Bacterial Toxins; D002352:Carrier Proteins; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins; D022622:Shiga Toxin 1; C066219:enterohemolysin; C073819:eaeA protein, E coli