Body temperature daily rhythms in the striped mouse Rhabdomys pumilio: the effects of alpha and beta blockade.
Body temperature (Tb) daily rhythms and the effects of alpha and beta blockade were studied in the South African diurnal striped mouse Rhabdomys pumilio. Eleven mice (8 males and 3 females) with a body mass of 42.7+/-7.8 g (mean +/- SD) were tested. Mice were acclimated to a 13 h:11 h light-dark photoperiod at an ambient temperature of 25 degrees C. To assess the daily rhythm of pineal melatonin secretion, urinary 6-sulfatoxymelatonin (6-SMT) was determined. Mice displayed a robust Tb daily rhythm with an acrophase in the dark period, which is unexpected for a diurnal species. The nocturnal increase in Tb was accompanied by a significant rise in urinary 6-SMT. The beta blocker propranolol (4.5 mg/kg), injected 1 h before lights-off, resulted in a higher Tb value, whereas the alpha blocker prazosin (1 mg/kg) blocked the increase of Tb during the dark period. Prazosin also significantly attenuated the nocturnal increase of urinary 6-SMT. These results are in agreement with those obtained from the golden spiny mouse Acomys russatus and support the idea that small diurnal mammals retain the Tb rhythm of a nocturnal rodent. They also suggest that pineal melatonin secretion in these rodents is regulated by alpha rather than by beta receptors.
Haim
A
A
Department of Biology, University of Haifa at Oranim, Kiryat Tivon, Israel.
Van Aarde
R J
RJ
Zisapel
N
N
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D005260:Female; D008297:Male; D008550:Melatonin / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009115:Muridae; D010870:Pineal Gland / Q000187:drug effects / Q000502:physiology; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D008550:Melatonin; D011224:Prazosin