title: Human milk IgA concentrations during the first year of lactation.
abstract: OBJECTIVE
  To measure the concentrations of total IgA in the milk secreted by both breasts, throughout the first year of lactation, in a cohort of Gambian mothers of infants at high risk of infection.
  
  
  METHODS
  Sixty five women and their infants were studied monthly from the 4th to 52nd postpartum week. Samples of milk were obtained from each breast by manual expression immediately before the infant was suckled. Milk intakes were measured by test weighing the infants before and after feeds over 12 hour periods; IgA concentrations were determined by enzyme linked immunosorbent assay.
  
  
  RESULTS
  A total of 1590 milk samples was measured. The median (interquartile range) concentration of IgA for all samples was 0.708 (0.422-1.105) g/l; that in milk obtained from the left breast was 0.785 (0.458-1.247) g/l, and that in milk obtained from the right breast was 0.645 (0.388-1.011) g/l (p < 0.0001). There was no significant change in milk or IgA intakes with advancing infant age, but there was a close concordance of IgA concentrations between the two breasts, with "tracking" of the output of the left and right breasts. There was a significant (p < 0.01) negative correlation between maternal age and parity, and weight of milk ingested by infants. During the dry season (December to May) the median (interquartile range) IgA concentration was significantly higher at 0.853 (0.571-1.254) g/l than during the rainy season (June to November), when it was 0.518 (0.311-0.909) g/l (p < 0.0001).
  
  
  CONCLUSIONS
  Sustained IgA secretion is likely to protect suckling infants from microbial infection.
authors.affiliation: Department of Child Health, University of Glasgow.
authors.forename: L T
authors.initials: LT
authors.lastname: Weaver
authors.forename: H M
authors.initials: HM
authors.lastname: Arthur
authors.forename: J E
authors.initials: JE
authors.lastname: Bunn
authors.forename: J E
authors.initials: JE
authors.lastname: Thomas
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D007223:Infant; D007774:Lactation / Q000276:immunology*; D008423:Maternal Age; D008892:Milk / Q000276:immunology*; D010298:Parity; D011446:Prospective Studies; D012621:Seasons
chemical_list: D007071:Immunoglobulin A, Secretory