Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.
Shen
H M
HM
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60617, USA.
Peters
A
A
Baron
B
B
Zhu
X
X
Storb
U
U
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005803:Genes, Immunoglobulin; D016259:Genes, myc; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007156:Immunologic Memory; D007438:Introns; D008297:Male; D008875:Middle Aged; D009154:Mutation; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051560:Proto-Oncogene Proteins c-bcl-6; D012269:Ribosomal Proteins / Q000235:genetics; D016385:TATA Box; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic; D000509:alpha-Fetoproteins / Q000235:genetics
D004268:DNA-Binding Proteins; D007143:Immunoglobulin Heavy Chains; D011518:Proto-Oncogene Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D012269:Ribosomal Proteins; D014157:Transcription Factors; D000509:alpha-Fetoproteins; C039747:ribosomal protein S14