title: [Combination therapy of endemic goiter with two different thyroxine/iodine combinations].
abstract: OBJECTIVE
  Of this study was to investigate the extent of thyrotropin (TSH) suppression and volume reduction in combination therapy of endemic goitre. We compared an individually adapted dose of thyroxine with a fixed dose.
  
  
  METHODS
  105 patients of a multicenter study (randomised, single blinded, controlled) received daily a weight-adjusted LT4-dose in combination with 150 micrograms iodide (group A) or a fixed combination of 100 micrograms LT4 plus 100 micrograms iodide (group B), respectively. At the beginning and after 12 weeks TSH-levels and goitre volume were examined.
  
  
  RESULTS
  Although the amount of thyrotropin suppression showed no differences in both groups, there were more patients in the weight-adjusted treatment group with completely suppressed thyrotropin serum concentrations (p < 0.05). Both groups showed a reduction of goitre volume of 24%
  
  
  CONCLUSIONS
  A weight-adjusted LT4-dose of 1.4 micrograms/kg body weight often leads to subclinical hyperthyroidism. To obtain low TSH-levels without complete suppression LT4-doses of 1.0 microgram/kg body weight plus 150 micrograms iodide are probably sufficient.
authors.affiliation: Abteilung Nuklearmedizin, Bundeswehrzentralkrankenhaus Koblenz, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Klemenz
authors.forename: G
authors.initials: G
authors.lastname: Förster
authors.forename: H
authors.initials: H
authors.lastname: Wieler
authors.forename: G
authors.initials: G
authors.lastname: Kahaly
authors.forename: K P
authors.initials: KP
authors.lastname: Kaiser
authors.forename: C
authors.initials: C
authors.lastname: Hansen
authors.forename: P
authors.initials: P
authors.lastname: Willkomm
authors.forename: J
authors.initials: J
authors.lastname: Ruhlmann
mesh_terms: D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006043:Goiter, Endemic / Q000188:drug therapy*; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology; D007455:Iodine / Q000627:therapeutic use*; D008297:Male; D016037:Single-Blind Method; D013960:Thyroid Function Tests; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D013973:Thyrotropin-Releasing Hormone; D007455:Iodine; D013974:Thyroxine
vernacular_title: Studie zur Kombinationstherapie der endemischen Struma mit zwei unterschiedlichen Thyroxin/Iodkombinationen.