Distribution of novel CGRP1 receptor and adrenomedullin receptor mRNAs in the rat central nervous system.
Recent cloning studies have isolated receptors which confer specific responsiveness to calcitonin gene related peptide (CGRP) and the related peptide adrenomedullin. Using in situ hybridisation, we demonstrate the heterogenous distribution of the mRNAs of two proposed CGRP1 receptors (RDC-1 and calcitonin receptor-like receptor, CRLR) in the rat brain. Adrenomedullin receptor mRNA was weakly expressed, principally in the cerebellum. These findings may assist in the determination of the function of these largely uncharacterised receptors.
Oliver
K R
KR
Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex CM20 2QR, UK. kevin_oliver@merck.com
Wainwright
A
A
Heavens
R P
RP
Hill
R G
RG
Sirinathsinghji
D J
DJ
D000679:Amygdala / Q000737:chemistry; D000818:Animals; D001923:Brain Chemistry; D019204:GTP-Binding Proteins / Q000235:genetics; D017403:In Situ Hybridization; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D017072:Neostriatum / Q000737:chemistry; D015345:Oligonucleotide Probes; D010841:Pia Mater / Q000737:chemistry; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000235:genetics*; D018000:Receptors, Peptide
D008565:Membrane Proteins; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide; D018000:Receptors, Peptide; D019204:GTP-Binding Proteins