[Effect of ethanol and polyethylene glycol-400 on frequency dependence of the inotropic effect of verapamil on the frog myocardium].
The PEG-400 was found to be neutral in respect to the frequency-dependent V negative inotropic action whereas ethanol enhanced this dependence. The findings suggest a possibility for V inotropic activity to be modified by lipophilic agents, provided they sterically complementary to hydrophobic domains of the Ca2(+)-channel structure.
Nesterov
V P
VP
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg, Russia.
Korotkov
S M
SM
Matveev
V V
VV
Demina
I N
IN
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003864:Depression, Chemical; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008970:Molecular Weight; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology*; D011896:Rana temporaria; D012997:Solvents; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D012997:Solvents; D000431:Ethanol; D011092:Polyethylene Glycols; D014700:Verapamil
Vliianie étanola i poliétilenglikolia-400 na chastotozavisimost' inotropnogo deĭstviia verapamila na serdechnuiu myshtsu liagushki.