title: Age of disease onset influences cognition in Parkinson's disease.
abstract: It is controversial whether age of disease onset is related to cognitive decline in Parkinson's disease (PD). We administered 7 cognitive measures assessing visuospatial skills, memory, and executive functions to 222 patients with idiopathic PD and 108 normal control participants. Regression analyses demonstrated that older age of disease onset consistently predicted cognitive decline above and beyond normative aging and duration of illness. These findings suggest that older age of disease onset is a critical determinant of cognitive deterioration in PD.
authors.affiliation: Department of Psychology, University of Miami, Coral Gables, FL, USA.
authors.forename: H L
authors.initials: HL
authors.lastname: Katzen
authors.forename: B E
authors.initials: BE
authors.lastname: Levin
authors.forename: M L
authors.initials: ML
authors.lastname: Llabre
mesh_terms: D017668:Age of Onset; D000368:Aged; D003071:Cognition / Q000502:physiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000523:psychology*; D012044:Regression Analysis