Iontophoretic transdermal delivery of salbutamol: methyl-orange ion-pair.
The influence of pulsed current duty cycle, addition of electrically neutral species and pH on iontophoretic transdermal delivery of an organic ion-pair salbutamol:methyl orange through excised rabbit abdominal skin is described. It was compared with salbutamol sulphate and salbutamol:sulphate ion-pair. It was found that there exists an optimum duty cycle range (1:3-1:4) at which iontophoretic flux of the ion-pair was at a maximum because of partition-electric current synchronization. Addition of mannitol decreases the flux of the ion-pair showing the important role of electroosmosis in ion-pair transport. The extremes of pH decrease the flux rates.
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Bharati Vidyapeeth's Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India.
Khopade
A J
AJ
Jain
N K
NK
D000279:Administration, Cutaneous; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D000420:Albuterol / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D001391:Azo Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D007474:Ion Exchange; D007478:Iontophoresis; D008353:Mannitol / Q000737:chemistry; D010539:Permeability; D011817:Rabbits; D012869:Skin Absorption
D000317:Adrenergic alpha-Antagonists; D001391:Azo Compounds; D007202:Indicators and Reagents; D008353:Mannitol; C100258:methyl orange; D000420:Albuterol