title: The evaluation and hazard classification of toxicological information for Workplace Hazardous Materials Information System material safety data sheets.
abstract: Hazardous materials used occupationally in Canada are subject to the legislated requirements of the Workplace Hazardous Materials Information System (WHMIS). This paper describes the administrative framework of WHMIS and how toxicological data are evaluated to determine if a substance triggers WHMIS classification for the toxicological endpoints of acute toxicity, skin irritation, eye irritation, corrosion, dermal sensitization, respiratory sensitization, chronic toxicity, mutagenicity, teratogenicity/embryotoxicity, and carcinogenicity. Problems encountered with the information on material safety data sheets are also discussed for each of the toxicological endpoints.
authors.affiliation: Workplace Hazardous Materials Information System Evaluation Section, Health Canada, Ottawa, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Côté
authors.forename: H
authors.initials: H
authors.lastname: Davis
authors.forename: C
authors.initials: C
authors.lastname: Dimock
authors.forename: M
authors.initials: M
authors.lastname: Korpan
authors.forename: K
authors.initials: K
authors.lastname: Loewen
authors.forename: L M
authors.initials: LM
authors.lastname: Segal
mesh_terms: D015197:Carcinogenicity Tests; D003343:Corrosion; D003872:Dermatitis / Q000209:etiology; D004357:Drug Synergism; D004622:Embryo, Mammalian / Q000187:drug effects; D009877:Endophthalmitis / Q000139:chemically induced; D005069:Evaluation Studies as Topic; D015386:Hazardous Substances / Q000145:classification* / Q000633:toxicity; D006801:Humans; D007256:Information Systems; D016273:Occupational Exposure; D012098:Reproduction / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects; D017751:Safety Management; D012867:Skin / Q000187:drug effects; D017132:Workplace
chemical_list: D015386:Hazardous Substances