title: Enhancement of the effect of methotrexate on collagen II induced arthritis in mice by nicotinamide.
abstract: Treatment with a combination of 10 mg/kg i.p. methotrexate and 100 mg/kg i.p. nicotinamide inhibits the development of collagen II induced arthritis in male DBA/1 X B.10(4R) mice, as assessed by the arthritic index and whole blood chemiluminescence. The effect is much more pronounced than with either methotrexate or nicotinamide alone at the same concentrations. Determination of GOT and GPT levels in the blood revealed that the treatment causes no toxic side effects on the liver.
authors.affiliation: Deutsches Rheumaforschungszentrum Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Kröger
authors.forename: A
authors.initials: A
authors.lastname: Hauschild
authors.forename: M
authors.initials: M
authors.lastname: Ohde
authors.forename: W
authors.initials: W
authors.lastname: Thefeld
authors.forename: D
authors.initials: D
authors.lastname: Krüger
authors.forename: K
authors.initials: K
authors.lastname: Bache
authors.forename: W
authors.initials: W
authors.lastname: Ehrlich
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D018501:Antirheumatic Agents / Q000494:pharmacology*; D001168:Arthritis / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology*; D001219:Aspartate Aminotransferases / Q000097:blood; D002417:Cattle; D003094:Collagen; D004357:Drug Synergism; D008163:Luminescent Measurements; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D008811:Mice, Inbred DBA; D009536:Niacinamide / Q000494:pharmacology*; D016897:Respiratory Burst / Q000187:drug effects
chemical_list: D018501:Antirheumatic Agents; D009536:Niacinamide; D003094:Collagen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008727:Methotrexate