title: [Assessment of degree of malignancy in non-Hodgkin B-cell lymphoma with immunophenotyping].
abstract: Due to immunophenotypic examination of bioptic samples from 30 patients with non-Hodgkin's lymphoma (NHL), malignancy of B-cell NHL was identified at an early stage of diagnosis, before histological analysis yielded the results. Negative expression of T-cell antigens, monoclonal character of light-weight chains of immunoglobulins, positive expression of B-cell antigens and marked expression of CD5+ are immunologic markers of low-malignancy B-cell NHL. A similar immunophenotypic pattern, involving negative expression of CD5- and positive one for Calla-antigen as well as one identifiable by monoclonal non-cluster antibody IPO3, is a marker of highly-malignant B-cell NHL.
authors.affiliation: Prof. N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
authors.forename: T M
authors.initials: TM
authors.lastname: Dzembak
authors.forename: V K
authors.initials: VK
authors.lastname: Gurkalo
authors.forename: M L
authors.initials: ML
authors.lastname: Gershanovich
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D018956:CD5 Antigens / Q000032:analysis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D018956:CD5 Antigens
vernacular_title: Otsenka stepeni zlokachestvennosti B-kletochnykh nekhodzhinskikh zlokachestvennykh limfom metodom immunofenotipirovaniia.