[Assessment of degree of malignancy in non-Hodgkin B-cell lymphoma with immunophenotyping].
Due to immunophenotypic examination of bioptic samples from 30 patients with non-Hodgkin's lymphoma (NHL), malignancy of B-cell NHL was identified at an early stage of diagnosis, before histological analysis yielded the results. Negative expression of T-cell antigens, monoclonal character of light-weight chains of immunoglobulins, positive expression of B-cell antigens and marked expression of CD5+ are immunologic markers of low-malignancy B-cell NHL. A similar immunophenotypic pattern, involving negative expression of CD5- and positive one for Calla-antigen as well as one identifiable by monoclonal non-cluster antibody IPO3, is a marker of highly-malignant B-cell NHL.
Dzembak
T M
TM
Prof. N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Gurkalo
V K
VK
Gershanovich
M L
ML
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D018956:CD5 Antigens / Q000032:analysis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D018956:CD5 Antigens
Otsenka stepeni zlokachestvennosti B-kletochnykh nekhodzhinskikh zlokachestvennykh limfom metodom immunofenotipirovaniia.