title: [Cough variant asthma among patients with chronic persistent cough and its clinical outcome].
abstract: Thirty-nine patients with chronic persistent cough continuing more than eight weeks were examined regarding to their airway responsiveness to methacholine challenge using the Astograph (TCK-6100H, Chest Corp. Japan). Of these, twenty-three individuals (59%) had airway hyperresponsiveness, leading to diagnose as having cough variant asthma (CVA). Patients with CVA had a higher percentage of eosinophils in peripheral blood and a lower forced expiratory volume in one second than those in non-CVA group. Furthermore, four patients (17%) developed the classic signs and symptoms of asthma, whereas 7 cases (30%) resolved their cough without further treatment and 12 cases (52%) continued to have CVA. These data suggested that a significant proportion of patients with chronic persistent cough had CVA and some of them may develop to classic wheezing asthma.
authors.affiliation: Department of Pulmonary Medicine, National Minami-Fukuoka Chest Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Iwanaga
authors.forename: S
authors.initials: S
authors.lastname: Inuzuka
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: R
authors.initials: R
authors.lastname: Kishikawa
authors.forename: K
authors.initials: K
authors.lastname: Yokota
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Hirose
authors.forename: H
authors.initials: H
authors.lastname: Tsurutani
authors.forename: S
authors.initials: S
authors.lastname: Nishima
mesh_terms: D001249:Asthma / Q000175:diagnosis*; D016535:Bronchial Hyperreactivity; D002908:Chronic Disease; D003371:Cough / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged
chemical_list: D016210:Methacholine Chloride