title: Virus dynamics: the effect of target cell limitation and immune responses on virus evolution.
abstract: Earlier models of virus evolution during single infections do not include target cell limitation. Here we extend the basic mathematical framework of these theories and study the effect of target cell limitation on the evolution of antigenic variation, increasing replication rates and increasing virus load. We find that target cell limitation provides a selection pressure against antigenic diversification, and can therefore provide a limit to diversity. Antigenic diversity increases virus load; at the maximum level of antigenic diversity, virus load, too, is at a maximum.
authors.affiliation: Department of Zoology, University of Oxford, U.K.
authors.forename: R R
authors.initials: RR
authors.lastname: Regoes
authors.forename: D
authors.initials: D
authors.lastname: Wodarz
authors.forename: M A
authors.initials: MA
authors.lastname: Nowak
mesh_terms: D000940:Antigenic Variation; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000821:virology*; D019562:Viral Load