Cellular targets and molecular responses associated with photodynamic therapy.
The positive clinical results associated with photodynamic therapy (PDT) have led to an expanded need to identify the cellular targets and molecular responses associated with this treatment. Increased knowledge regarding the mechanisms of action associated with PDT-mediated cytotoxicity should contribute to the continued advancement of this therapy. This report focuses on recent studies analyzing PDT resistance and examining stress protein and early response gene activation induced by photosensitizer mediated oxidative stress. Recurring observations from these studies indicate that subcellular targets and cellular responses associated with PDT can vary significantly for different photosensitizers.
Gomer
C J
CJ
Clayton Ocular Oncology Center, Childrens Hospital of Los Angeles, California 90027, USA.
Luna
M
M
Ferrario
A
A
Wong
S
S
Fisher
A M
AM
Rucker
N
N
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D017323:Dihematoporphyrin Ether / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D005260:Female; D005354:Fibrosarcoma / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D018869:Heat-Shock Response / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011166:Porphyrins / Q000494:pharmacology; D011519:Proto-Oncogenes / Q000502:physiology; D015533:Transcriptional Activation; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D018840:HSP70 Heat-Shock Proteins; D017319:Photosensitizing Agents; D011166:Porphyrins; C063166:tin etiopurpurin; D017323:Dihematoporphyrin Ether; C053434:Talaporfin