title: Synthetic strategies for the preparation of precursor polymers and of microcapsules suitable for cellular entrapment by polyelectrolyte complexation of those polymers.
abstract: The production of microcapsules suitable for the entrapment of mammalian cell by means of polyelectrolyte complexation has, of a necessity, led to the development of novel strategies for the preparation of relatively bioinert polymers which complex efficiently under unique conditions to produce a mechanically resilient membrane with efficient transport properties. In this communication we relate a brief overview of capsule-membrane forming systems for the immunoisolation (or potential immunoisolation) of mammalian cells, which are based upon the complexation of polyelectrolyte (PE) polymers; with emphasis on precursor synthesis and relationships between precursor polymer structure and capsule membrane stability.
authors.affiliation: Department of Chemistry, Wichita State University, Kansas 67260-0051, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Dyakonov
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.forename: Z
authors.initials: Z
authors.lastname: Wan
authors.forename: B
authors.initials: B
authors.lastname: Huang
authors.forename: Z
authors.initials: Z
authors.lastname: Meng
authors.forename: X
authors.initials: X
authors.lastname: Guo
authors.forename: H
authors.initials: H
authors.lastname: Alexander
authors.forename: W V
authors.initials: WV
authors.lastname: Moore
authors.forename: W T
authors.initials: WT
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D002214:Capsules / Q000138:chemical synthesis*; D016503:Drug Delivery Systems; D004573:Electrolytes; D006801:Humans; D008958:Models, Molecular; D011108:Polymers / Q000138:chemical synthesis*
chemical_list: D002214:Capsules; D004573:Electrolytes; D011108:Polymers