title: Acute changes in endometrial thickness after aspiration of functional ovarian cysts.
abstract: OBJECTIVE
  To evaluate the influence of aspiration of functional ovarian cysts on endometrial thickness.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  An IVF Unit of an academic medical center.
  
  
  METHODS
  Twenty-two patients from our IVF program, in whom administration of a gonadotropin-releasing hormone agonist preparation in the "long protocol" failed to induce pituitary desensitization, as evidenced by a serum E2 concentration of >55 pg/mL and the presence of an ovarian cyst of >20 mm in diameter.
  
  
  METHODS
  Transvaginal ultrasonographic-guided cyst aspiration was performed, and 2 days later, serum E2 concentration and endometrial thickness were reassessed.
  
  
  METHODS
  The values of serum E2 concentration and endometrial thickness before and after cyst aspiration were compared.
  
  
  RESULTS
  Two days after ovarian cyst aspiration, the serum E2 concentration dropped from a mean (+/-SD) of 203 +/- 93 to 37 +/- 34 pg/mL. The mean (+/-SD) endometrial thickness was 9.6 +/- 2.0 mm before cyst aspiration and decreased to 5.9 +/- 2.4 mm after the procedure.
  
  
  CONCLUSIONS
  Within 48 hours after ovarian cyst aspiration, a significant reduction in endometrial thickness occurs concomitant with a sharp decline in serum E2 levels. The phenomenon of acute reduction in endometrial thickness in response to acute estrogen withdrawal has not been described previously. The exact mechanism and endometrial component involved in the "shrinking" process should be further investigated.
authors.affiliation: Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Weissman
authors.forename: A
authors.initials: A
authors.lastname: Barash
authors.forename: M
authors.initials: M
authors.lastname: Manor
authors.forename: A
authors.initials: A
authors.lastname: Ben-Arie
authors.forename: I
authors.initials: I
authors.lastname: Granot
authors.forename: Z
authors.initials: Z
authors.lastname: Shoham
mesh_terms: D000328:Adult; D001706:Biopsy; D004322:Drainage; D004717:Endometrium / Q000473:pathology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D009994:Osmolar Concentration; D010048:Ovarian Cysts / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D004958:Estradiol