Toxicologic evaluation of yessotoxin.
Yessotoxin (YTX), originally found in association with diarrhetic shellfish poisoning (DSP), caused neither intestinal fluid accumulation nor inhibition of protein phosphatase 2A. Orally, YTX was not lethal to mice at 1.0 mg/kg. The toxin showed weak cytotoxic and antifungal activities. Neither hemolytic nor ichthyotoxic effect was observed.
Ogino
H
H
Kagome Research Institute, Kagome Co., Ltd., Tochigi, Japan.
Kumagai
M
M
Yasumoto
T
T
D000818:Animals; D000833:Animals, Suckling; D000890:Anti-Infective Agents / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000633:toxicity; D004988:Ethers, Cyclic / Q000494:pharmacology / Q000633:toxicity*; D006461:Hemolysis / Q000187:drug effects; D008297:Male; D051379:Mice; D008978:Mollusk Venoms / Q000494:pharmacology / Q000633:toxicity*; D035964:Oxocins; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors; D054648:Protein Phosphatase 2; D015027:Zebrafish
D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D004988:Ethers, Cyclic; D008978:Mollusk Venoms; D035964:Oxocins; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2; C066632:yessotoxin