[Experimental study of therapeutical properties and safety of king crab collagenase-containing ointment].
The effects of ointment containing king crab (Paralithodes camtschatica) collagenase on intact skin, thermal, and pyonecrotic wounds were studied in rats by using hematological, biochemical, immunological, and morphological methods. The ointment for the skin and viscera was shown to be safe. It is highly effective in debriding the infected wounds. Different concentrations of collagenase were tested. The concentration of collagenase was recommended to be 0.2 mg/g ointment for use.
Sandakhchiev
L S
LS
Stavskiĭ
E A
EA
Zinov'ev
V V
VV
Nazarov
V P
VP
Renau
I V
IV
Satrikhina
T N
TN
Katkova
L R
LR
Krinitsin
L A
LA
Kolesnikova
L V
LV
Taranov
O S
OS
Omigov
V V
VV
Ovechkina
L G
LG
Markovich
N A
NA
Malygin
E G
EG
Danilenko
E D
ED
Voevoda
T V
TV
Fedosova
L K
LK
Sizova
L Iu
LIu
Masycheva
V I
VI
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000009:adverse effects / Q000302:isolation & purification; D003386:Brachyura / Q000201:enzymology*; D017364:Collagenases / Q000008:administration & dosage* / Q000009:adverse effects / Q000302:isolation & purification; D004195:Disease Models, Animal; D008297:Male; D009824:Ointments; D051381:Rats; D011917:Rats, Inbred Lew; D012449:Safety; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000188:drug therapy / Q000473:pathology
D000891:Anti-Infective Agents, Local; D009824:Ointments; D017364:Collagenases
Eksperimental'noe izuchenie lechebnykh svoĭstv mazi, soderzhashcheĭ kollagenazu kamchatskogo kraba.