title: Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome: results of a case-control study.
abstract: Polycystic ovary syndrome (PCOS), a disorder of hyperandrogenism and chronic anovulation affects 5%-10% of all women. Women with PCOS often have elevated cardiovascular risk factors. A total of 244 PCOS cases were identified through the Division of Reproductive Endocrinology at Magee-Womens Hospital and were age-matched to 244 neighborhood controls. The average age of cases and controls was 35.3 +/- 7.4 and 36.7 +/- 7.7. Women with PCOS compared to controls had substantially higher LDL-C and total cholesterol levels at each age group under 45 years after adjustment for body mass index, hormone use, and insulin levels. In the over 40-year age group, little difference was noted between cases and controls. Among cases and controls (<40), PCOS predicted LDL-C, total cholesterol and triglycerides, but did not have a significant effect on lipid levels in older cases and controls after controlling for the other variables. The primarily pre- to perimenopausal PCOS cases > or =40 years of age have similar LDL-C and total cholesterol levels as their age-matched controls, probably reflecting the LDL-C increase with age among controls.
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA.
authors.forename: E
authors.initials: E
authors.lastname: Talbott
authors.forename: A
authors.initials: A
authors.lastname: Clerici
authors.forename: S L
authors.initials: SL
authors.lastname: Berga
authors.forename: L
authors.initials: L
authors.lastname: Kuller
authors.forename: D
authors.initials: D
authors.lastname: Guzick
authors.forename: K
authors.initials: K
authors.lastname: Detre
authors.forename: T
authors.initials: T
authors.lastname: Daniels
authors.forename: R A
authors.initials: RA
authors.lastname: Engberg
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood*; D016555:Matched-Pair Analysis; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D018709:Statistics, Nonparametric
chemical_list: D008078:Cholesterol, LDL; D008055:Lipids