Cloning and tissue distribution of the human G protein beta 5 cDNA.
Heterotrimeric G proteins integrate signals between receptors and effector proteins. We have cloned the human beta 5 subunit from a human brain cDNA library. The clone has a 1059 bp open reading frame and is highly homologous to the murine clone. In contrast to the brain specific mouse beta 5, northern analysis showed it to be expressed in multiple tissues.
Jones
P G
PG
Wyeth-Ayerst Research, Princeton, NJ 08543, USA. jonesp1@war.wyeth.com
Lombardi
S J
SJ
Cockett
M I
MI
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000302:isolation & purification*; D044387:GTP-Binding Protein beta Subunits; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D020962:Heterotrimeric GTP-Binding Proteins; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; C490611:GNB5 protein, human; D044387:GTP-Binding Protein beta Subunits; C094668:Gnb5 protein, mouse; D019204:GTP-Binding Proteins; D020962:Heterotrimeric GTP-Binding Proteins