Dose-related effects of shock waves on rabbit tendo Achillis. A sonographic and histological study.
We aimed to determine whether extracorporeal shock waves of varying intensity would damage the intact tendo Achillis and paratenon in a rabbit model. We used 42 female New Zealand white rabbits randomly divided into four groups as follows: group a received 1000 shock-wave impulses of an energy flux density of 0.08 mJ/mm2, group b 1000 impulses of 0.28 mJ/mm2, group c 1000 impulses of 0.60 mJ/mm2, and group d was a control group. Sonographic and histological evaluation showed no changes in group a, and transient swelling of the tendon with a minor inflammatory reaction in group b. Group c had formation of paratendinous fluid with a significant increase in the anteroposterior diameter of the tendon. In this group there were marked histological changes with increased eosin staining, fibrinoid necrosis, fibrosis in the paratenon and infiltration of inflammatory cells. We conclude that there are dose-dependent changes in the tendon and paratenon after extracorporeal shock-wave therapy and that energy flux densities of over 0.28 mJ/mm should not be used clinically in the treatment of tendon disorders.
Rompe
J D
JD
Department of Orthopaedics, Johannes Gutenberg Medical School, Mainz, Germany.
Kirkpatrick
C J
CJ
Küllmer
K
K
Schwitalle
M
M
Krischek
O
O
D000125:Achilles Tendon / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects*; D000818:Animals; D002196:Capillaries / Q000473:pathology; D003094:Collagen / Q000648:ultrastructure; D004108:Dilatation, Pathologic / Q000473:pathology; D004307:Dose-Response Relationship, Radiation; D004487:Edema / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D004801:Eosine Yellowish-(YS); D004912:Erythrocytes / Q000473:pathology; D005122:Exudates and Transudates; D005205:Fascia / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects*; D005208:Fasciitis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D005260:Female; D005355:Fibrosis; D005456:Fluorescent Dyes; D005500:Follow-Up Studies; D019220:High-Energy Shock Waves; D009336:Necrosis; D009504:Neutrophils / Q000473:pathology; D011817:Rabbits; D011829:Radiation Dosage; D011897:Random Allocation; D052256:Tendinopathy / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D014463:Ultrasonography
D005456:Fluorescent Dyes; D003094:Collagen; D004801:Eosine Yellowish-(YS)