Vagotomy in young obese hyperglycemic mice: effects on syndrome development and islet proliferation.
Obese hyperglycemic mice have large pancreatic islets and high levels of serum insulin and blood glucose. Vagotomy was performed on 3-wk-old animals to investigate the role of gut cholinergic innervation in young Umea ob/ob mice. After vagotomy, obesity and hyperglycemia are dissociated. Weight increase in obese vagotomized mice was lower than in sham-operated controls during the 1st wk postoperatively but not thereafter. Blood glucose was lower up to 5 mo after vagotomy, but vagotomized mice showed reduced glucose tolerance. Islet cell proliferation rate was reduced 2 and 3 wk but not 5 mo after vagotomy. After 5 mo, islet volume was smaller in vagotomized mice. Serum insulin levels were the same in vagotomized animals as in sham-operated controls. The effects of reduced cholinergic innervation are probably caused both by direct effects of denervation and by lowered metabolic demand.
Edvell
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A
Department of Histology and Cell Biology, Umea University, S-90187 Umea, Sweden.
Lindström
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P
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002455:Cell Division; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000473:pathology*; D007700:Kinetics; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D014628:Vagotomy; D015430:Weight Gain
D001786:Blood Glucose; D007328:Insulin