title: [Determination of natural antibodies to catecholamines in health and disease].
abstract: OBJECTIVE
  Enzyme immunoassay (EIA) determination of the level of natural antibodies (n-Ab) to catecholamines in patients with metabolic disturbances and cardiovascular diseases, correlation between content of n-Ab to these bioregulators and clinical diagnosis, biochemical indices.
  
  
  METHODS
  EIA with specially synthetized artificial antigens was used to determine n-Ab to catecholamines (adrenaline, noradrenaline, dopamin) in 41 patients with cardiovascular diseases and metabolic disturbances (ischemic heart disease, essential hypertension, hyperlipoproteinemia) and in 10 healthy subjects (donors, controls).
  
  
  RESULTS
  Changes in the levels of antibodies to catecholamines correspond to the clinical diagnosis. Interrelations exist between n-Ab to catecholamines and biochemical parameters in the disease.
  
  
  CONCLUSIONS
  The trends in the amount of n-Ab to catecholamines are a unique marker of metabolic disturbances of these endogenic substances and can be used in diagnosis.
authors.forename: M A
authors.initials: MA
authors.lastname: Miagkova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Savitskaia
authors.forename: Zh N
authors.initials: ZhN
authors.lastname: Trubacheva
authors.forename: O N
authors.initials: ON
authors.lastname: Panchenko
authors.forename: A V
authors.initials: AV
authors.lastname: Pogozheva
authors.forename: N M
authors.initials: NM
authors.lastname: Aminova
authors.forename: I A
authors.initials: IA
authors.lastname: Rozanova
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D002318:Cardiovascular Diseases / Q000276:immunology*; D002395:Catecholamines / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D008659:Metabolic Diseases / Q000276:immunology*; D012680:Sensitivity and Specificity
chemical_list: D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers; D002395:Catecholamines; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Opredelenie estestvennykh antitel k katekholaminam v norme i pri patologii.