title: Metabolic and hormonal responses to exercise in partially hepatectomised rats.
abstract: To characterise how the liver affects metabolic and hormonal exercise responses, hepatectomised (70%; HX) rats were submitted to a 30- or 50-min treadmill exercise (26 m/min, 0% slope) 48 hr or 7 days after surgery (reduced or normal liver mass, respectively). To determine whether metabolic effects of liver mass reduction during exercise were caused by reduced capacity of the liver to produce glucose, metabolic and hormonal responses to the same exercise protocol were measured in 48-hr HX rats. Euglycemia, maintained by exogenous glucose infusion, produced attenuated lactate, insulin, and glucagon values in 48-hr HX rats but did not affect FFA, glycerol, and plasma catecholamine responses. Results indicate that metabolic and hormonal exercise responses are amplified in 48-hr HX rats. Maintaining euglycemia in 48-hr HX rats during exercise does not reduce all responses. Intrahepatic events, similar to those in a short-term (48-hr) HX liver, may influence metabolic and hormonal exercise responses.
authors.affiliation: Department of Physical Education, Université de Montréal, PQ, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Lavoie
authors.forename: C
authors.initials: C
authors.lastname: Warren
authors.forename: K
authors.initials: K
authors.lastname: Arcelin
authors.forename: M G
authors.initials: MG
authors.lastname: Latour
authors.forename: F
authors.initials: F
authors.lastname: Désy
authors.forename: M
authors.initials: M
authors.lastname: Shinoda
authors.forename: C
authors.initials: C
authors.lastname: Ethier
authors.forename: M
authors.initials: M
authors.lastname: Gascon-Barré
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005947:Glucose / Q000494:pharmacology; D005990:Glycerol / Q000097:blood; D006498:Hepatectomy / Q000379:methods*; D006728:Hormones / Q000097:blood*; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006728:Hormones; D019344:Lactic Acid; D005947:Glucose; D005990:Glycerol