99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and in vivo.
The aim of this study was to compare uptake of 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and biodistribution in vivo in rats. In vitro, uptake decreased in the order MIBI-->tetrofosmin-->Q12. Uptake of MIBI and tetrofosmin, but not of Q12, in cultured tumor cells was dependent on the plasma membrane and mitochondrial potential. In vivo, heart uptake of all three compounds was high and stable. Tumor uptake decreased in the order MIBI-->Q12-->tetrofosmin and the tumor/blood ratio in the order MIBI-->tetrofosmin-->Q12.
Bernard
B F
BF
Department of Nuclear Medicine, University Hospital Dijkzigt and Erasmus University Medical School, Rotterdam, The Netherlands.
Krenning
E P
EP
Breeman
W A
WA
Ensing
G
G
Benjamins
H
H
Bakker
W H
WH
Visser
T J
TJ
de Jong
M
M
D000818:Animals; D001692:Biological Transport; D001943:Breast Neoplasms; D002462:Cell Membrane / Q000502:physiology; D005260:Female; D005663:Furans / Q000493:pharmacokinetics*; D006801:Humans; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured
D005663:Furans; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078496:technetium Tc 99m Q12; C078700:technetium tc-99m tetrofosmin; D017256:Technetium Tc 99m Sestamibi