Normal postexercise facilitation and depression of motor evoked potentials in postpolio patients.
We studied the effects of exercise on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation in healthy subjects and postpolio patients. Subjects performed repeated sets of isometric exercise until the muscle fatigued. In both groups, the mean MEP amplitude immediately after each exercise set was approximately twice that of the baseline amplitude, indicating similar postexercise facilitation, and after fatigue was approximately half that of the baseline amplitude, indicating similar postexercise depression. We conclude that the intracortical component of central fatigue is normal in postpolio patients.
Samii
A
A
Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA.
Lopez-Devine
J
J
Wasserman
E M
EM
Dalakas
M C
MC
Clark
K
K
Grafman
J
J
Hallett
M
M
D000328:Adult; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology*; D018763:Muscle Fatigue / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D016262:Postpoliomyelitis Syndrome / Q000503:physiopathology*