Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora. II. Structural studies.
The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.
Hori
H
H
Faculty of Agriculture, Tamagawa University, Tokyo, Japan.
Igarashi
Y
Y
Kajiura
T
T
Furumai
T
T
Higashi
K
K
Ishiyama
T
T
Uramota
M
M
Uehara
Y
Y
Oki
T
T
D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D015398:Signal Transduction / Q000187:drug effects*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D004791:Enzyme Inhibitors; D011505:Protein-Tyrosine Kinases