[Regulation of megakaryopoiesis and thrombopoiesis by thrombopoietin].
Thrombopoietin (TPO) is a major hematopoietic growth factor which regulates the production of megakaryocytes and platelets. Recent cloning of its c-DNA and availability of recombinant TPO have enabled us to examine the biological effects of TPO in various systems, including human platelets. In this review, we briefly describe the recent progresses made in the studies of TPO and its cognate receptor, c-Mp1.
Oda
A
A
Department of Internal Medicine, School of Medicine, Keio University, Tokyo.
Ikeda
Y
Y
D001792:Blood Platelets / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D008533:Megakaryocytes / Q000502:physiology*; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins / Q000097:blood; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; D013926:Thrombopoietin / Q000502:physiology*
D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; C082218:MPL protein, human; D013926:Thrombopoietin