[Morphological changes in muscular arterial walls in hypertensive patients].
OBJECTIVE
To identify structural lesions in the wall of uterine arteries in hypertensive women.


METHODS
Twenty six patients who underwent an elective hysterectomy were selected and separated in two groups. Group 1 was formed by women with normal blood pressure and group 2 consisted of hypertensive patients without regular treatment. Two segments of the uterine artery were obtained from every patient shortly after surgery. The fragments were fixed, sliced and stained. The morphological study was carried out using optical microscopy.


RESULTS
Age was similar in both groups with means of 46.8 +/- 7.6 and 46.7 +/- 6.4 years-old in groups 1 and 2, respectively. The average maximal systolic and diastolic blood pressure during hospital admission were 130.0 +/- 3.4 and 83.8 +/- 6.5 mmHg in the control group and 163.8 +/- 4.3 and 105.8 +/- 9.9 mmHg in the hypertensive group (p < 0.0001). Hypertensive women had larger intimal thickness (p < 0.05). Elastic fibers were also more numerous and homogeneous in group 2. Cellular hypertrophy was more common in this group than in control patients (53.8% vs 23.1%).


CONCLUSIONS
Hypertension seems to accelerate the age-related increase in intima thickness. Hypertensive women have more numerous and homogeneous elastic fibers in the wall of the uterine artery. These findings indicate that hypertension may determine structural changes similar to vascular aging.
Neves
M F
MF
Universidade do Estado do Rio de Janeiro.
Souza
J F
JF
Oigman
W
W
D001158:Arteries / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D008875:Middle Aged; D009215:Myometrium / Q000098:blood supply*
Alterações morfológicas na parede de artéria muscular em pacientes hipertensas.