Studies of the effect of physical and chemical interactions of cellulose ethers and sulfonamides in tablets on the drug release.
The paper reports results of the studies of sulfonamide tablets obtained by the incorporation in hydrophilic carrier (Cellulose ether). The rate of sulfonamide release was determined by the paddle method. The occurrence of physical and chemical interactions of sulfonamides and cellulose ethers in the solid phase was confirmed by X-ray diffraction and thermal (TG and DSC) studies. The influence of these interactions on the sulfonamide release from the tablets was analyzed.
Hładoń
T
T
Department of Inorganic and Analytical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
Cwiertnia
B
B
D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D013449:Sulfonamides / Q000737:chemistry*; D013607:Tablets
D013449:Sulfonamides; D013607:Tablets; D002482:Cellulose