Effect of carbamazepine on cytochromes P4502B 1/2B2 in rats exposed to high environmental temperature.
The combined effect of carbamazepine (CBZ) and raised environmental temperature on total hepatic cytochrome P450 and on cytochromes P4502B1/2B2 contents was investigated. Carbamazepine produced significant increase of the contents of total cytochrome P450 and cytochromes P4502B1/2B2 in rats exposed to 21 degrees C and 28 degrees C. In contrast exposure of rats of 35 degrees C decreased induction capacity of carbamazepine.
Kobylińska
K
K
Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Poland.
Pachecka
J
J
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001189:Aryl Hydrocarbon Hydroxylases; D002220:Carbamazepine / Q000494:pharmacology*; D019362:Cytochrome P-450 CYP2B1 / Q000096:biosynthesis*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013250:Steroid Hydroxylases / Q000096:biosynthesis*; D013696:Temperature
D000927:Anticonvulsants; D002220:Carbamazepine; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; D019362:Cytochrome P-450 CYP2B1; C025619:steroid 16-beta-hydroxylase