[Cytogenetic analysis of hypophyseal adenoma. Study of 9 cases and review of the literature].
BACKGROUND
To the best of our knowledge, no specific chromosomal abnormalities have been found in the literature in pituitary adenomas. In the present study, we investigated 9 cases of pituitary adenoma and reviewed the current literature.


METHODS
Nine cases of pituitary adenoma have been studied with immunohistochemistry and cytogenetic using short-term cultures.


RESULTS
All tumors had a normal karyotype. Three cases were clinically non-secreting adenomas, three cases produced prolactin, two showed growth hormone production and one thyroid-stimulating hormone. One of the cases showed dural invasion.


CONCLUSIONS
We compared our results with those published in the current literature. It appears that pituitary adenomas do not have specific numerical and structural abnormalities and mostly show a normal karyotype.
Buonamici
L
L
Dipartimento di Oncologia, Ospedale Bellaria, Università di Bologna.
Roncaroli
F
F
Frank
G
G
Dal Cin
P
P
Van den Berghe
H
H
Calbucci
F
F
Eusebi
V
V
D000236:Adenoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011388:Prolactin / Q000378:metabolism; D015175:Prolactinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D013972:Thyrotropin / Q000378:metabolism
D019382:Human Growth Hormone; D011388:Prolactin; D013972:Thyrotropin
Analisi citogenetica degli adenomi ipofisari. Studio di 9 casi e revisione della letteratura.