title: Adult granulosa cell tumor of the ovary: a clinico pathologic study of 35 cases.
abstract: OBJECTIVE
  Adult granulosa cell tumor has a low malignant potential but requires an extensive follow-up of more than 5 years to accurately assess tumor activity. The aim of the present study was to evaluate the clinical characteristics, the treatment and the outcome of this rare ovarian tumor.
  
  
  METHODS
  A retrospective review of 35 cases treated at primary onset of disease during a 23-year period from 1971 to 1993.
  
  
  RESULTS
  The disease-free survival rate for stages IA-B-C at 5 and 10 years was 90% and 84%, respectively; for stages III-IV the 5-year freedom from progression rate was 16%.
  
  
  CONCLUSIONS
  The most important prognostic factor appears to be the extent of tumor involvement outside of the ovary.
authors.affiliation: Division of Gynecologic Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Fontanelli
authors.forename: B
authors.initials: B
authors.lastname: Stefanon
authors.forename: F
authors.initials: F
authors.lastname: Raspagliesi
authors.forename: R
authors.initials: R
authors.lastname: Kenda
authors.forename: G
authors.initials: G
authors.lastname: Tomasic
authors.forename: G
authors.initials: G
authors.lastname: Spatti
authors.forename: G
authors.initials: G
authors.lastname: Riboldi
authors.forename: P
authors.initials: P
authors.lastname: Di Donato
authors.forename: S
authors.initials: S
authors.lastname: Pilotti
authors.forename: G
authors.initials: G
authors.lastname: De Palo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome