[Several parameters of the state of the nervous, immune and endocrine systems in newborn rats exposed to irradiation during the preimplantation period of embryogenesis].
Protracted prenatal irradiation of animals at the preimplantation stage of embryogenesis is shown to produce disturbances in the development of regulation systems, with their consequences persisting up to sexually mature period of postnatal life. Unknown before, these effects of preimplantation irradiation give the experimental confirmation to the main statement of the previously proposed theoretical concept of the "systemic teratogenesis": the ultimate effect of prenatal irradiation is a distortion of the structure of postnatal neuroimmunoendocrine regulation in the direction of overdevelopment of its endocrine component with the following coadaptive underdevelopment of the nervous and immune components.
Filiushkin
I V
IV
State Research Centre of Russia Federation, Institute of Biophysics, Moscow.
Ignatov
A N
AN
Leshchenko
M V
MV
Makashina
O M
OM
Kashirin
V S
VS
Stetsenko
A V
AV
Gruden'
M A
MA
Shumova
E A
EA
Bel'chenko
A N
AN
D000016:Abnormalities, Radiation-Induced / Q000209:etiology*; D000311:Adrenal Glands / Q000528:radiation effects; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation / Q000276:immunology / Q000528:radiation effects; D001755:Blastocyst / Q000528:radiation effects*; D002588:Cesium Radioisotopes / Q000008:administration & dosage; D004703:Endocrine System / Q000196:embryology / Q000528:radiation effects*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007107:Immune System / Q000196:embryology / Q000528:radiation effects*; D007328:Insulin / Q000097:blood; D009420:Nervous System / Q000196:embryology / Q000528:radiation effects*; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D012867:Skin / Q000382:microbiology / Q000528:radiation effects
D002588:Cesium Radioisotopes; D007328:Insulin; D000324:Adrenocorticotropic Hormone
Nekotorye pokazateli sostoianiia nervnoĭ, immunnoĭ i éndokrinnoĭ sistem u novorozhdennykh krys, podvergshikhsia oblucheniiu v doimplantasionnyĭ period émbriogeneza.