title: Human immunodeficiency virus-2 infection in baboons is an animal model for human immunodeficiency virus pathogenesis in humans.
abstract: OBJECTIVE
  To assess disease progression in baboons (Papio cynocephalus) that were infected with two human immunodeficiency virus-2 (HIV-2) isolates.
  
  
  METHODS
  Eight baboons were inoculated intravenously with either HIV-2UC2 or HIV-2UC14 and were followed for a 2- to 7-year period of observation.
  
  
  RESULTS
  Six of 8 baboons showed lymphadenopathy and other signs of HIV-related disease, 3 of 8 baboons had an acute phase CD4+ T-cell decline, and 2 of 5 baboons infected with the HIV-2UC2 isolate progressed to an acquired immunodeficiency syndrome-like disease. Human immunodeficiency virus-2-specific pathology in lymphatic tissues included follicular lysis, vascular proliferation, and lymphoid depletion. Both neutralizing antibodies and a CD8+ T-cell antiviral response were associated with resistance to disease.
  
  
  CONCLUSIONS
  Disease progression and the development of acquired immunodeficiency syndrome in HIV-2-infected baboons have similarities to human HIV infections.
authors.affiliation: Department of Medicine, University of California, San Francisco, 94143-1270, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Locher
authors.forename: S W
authors.initials: SW
authors.lastname: Barnett
authors.forename: B G
authors.initials: BG
authors.lastname: Herndier
authors.forename: D J
authors.initials: DJ
authors.lastname: Blackbourn
authors.forename: G
authors.initials: G
authors.lastname: Reyes-Terán
authors.forename: K K
authors.initials: KK
authors.lastname: Murthy
authors.forename: K M
authors.initials: KM
authors.lastname: Brasky
authors.forename: G B
authors.initials: GB
authors.lastname: Hubbard
authors.forename: T A
authors.initials: TA
authors.lastname: Reinhart
authors.forename: A T
authors.initials: AT
authors.lastname: Haase
authors.forename: J A
authors.initials: JA
authors.lastname: Levy
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D005350:Fibroma / Q000473:pathology; D015658:HIV Infections / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D015498:HIV-2 / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D017403:In Situ Hybridization; D008206:Lymphatic Diseases / Q000473:pathology; D008297:Male; D009500:Neutralization Tests; D010215:Papio / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D012514:Sarcoma, Kaposi / Q000473:pathology; D014779:Virus Replication / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral