Long-term survival in cerebral glioblastoma. Case report and critical review of the literature.
Glioblastoma multiforme is the most malignant tumor of the glial series. The average survival of patients with this tumor ranges from 6 to 12 months. The case of a patient who survived for more than 11 years after diagnosis of a temporal-occipital glioblastoma which was treated with surgery, radiotherapy and chemotherapy is described. The authors deduce that among patients with glioblastoma multiforme (GM), those with a long disease-free interval after initial diagnosis who undergo multimodal therapy, including aggressive tumor removal, are the most likely long-term survivors (LS). Other factors which appeared to be related to longer survival were younger age and high Karnofsky scores.
Puzzilli
F
F
Department of Neurological Sciences, University of Rome La Sapienza, Italy.
Ruggeri
A
A
Mastronardi
L
L
Di Stefano
D
D
Lunardi
P
P
D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005909:Glioblastoma / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology; D017741:Survivors; D013702:Temporal Lobe / Q000473:pathology; D013997:Time Factors