[Mycobacterium genavense infection in 2 HIV seropositive patients in Amsterdam].
Two patients with an HIV-I infection, a man aged 47 with confusion, aphasia and diarrhoea, and a man aged 32 with dysphagia, a non-productive cough and diarrhoea, were diagnosed as having a disseminated Mycobacterium genavense infection. Both had low counts of CD4+ T lymphocytes. They responded to antimycobacterial treatment. M. genavense was recognized in Geneva in the early nineties as a causative agent of disseminated mycobacterial infections in HIV-seropositive patients with poor cellular immunity. The clinical picture resembles that of a generalized infection with M. avium-intracellulare. M. genavense is a slowly growing mycobacterium which can be isolated and identified using enriched nutrient media and molecular-biological techniques. The infection probably begins in the gastrointestinal tract after oral contamination. DNA of M. genavense can be demonstrated in 25% of the intestinal biopsy samples of non-HIV-seropositive patients.
Kuijper
E J
EJ
Universiteit van Amsterdam, Academisch Medisch Centrum, Amsterdam.
de Witte
M
M
Verhagen
D W
DW
Kolk
A H
AH
van der Meer
J T
JT
Dankert
J
J
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents; D018791:CD4 Lymphocyte Count; D003371:Cough / Q000209:etiology; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000209:etiology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis* / Q000188:drug therapy; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents
Infectie met Mycobacterium genavense bij 2 HIV-seropositieve patiënten in Amsterdam.