Clinical significance of tumor angiogenesis in patients with localized renal cell carcinoma.
OBJECTIVE
To determine the relationship between angiogenesis and various histopathologic features as well as clinical outcome in patients with localized renal cell carcinoma (RCC).


METHODS
Microvessel density was quantified by using immunocytochemical staining of endothelial cells for factor VIII-related antigen of 36 specimens taken from patients with pathologic Stage pT1 or pT2 RCC. All patients underwent radical nephrectomy and were followed for a mean time of 97.3 months.


RESULTS
No association was noted between microvessel count (MVC) and either cell type, architecture, or tumor size. Inverse correlation was noted between MVC and nuclear area (P = 0.006), nuclear elipticity (P = 0.016), nuclear roughness (P = 0.039), and histologic grade (P = 0.047). Patients having tumors with low MVC had significantly better survival rate compared with those with high MVC neoplasms (P = 0.0014, by Cox proportional hazards method).


CONCLUSIONS
Despite lack of correlation with known predictors of survival, MVC provides independent prognostic information for patients with localized RCC.
Nativ
O
O
Department of Urology, Bnai Zion Medical Center, Haifa, Israel.
Sabo
E
E
Reiss
A
A
Wald
M
M
Madjar
S
S
Moskovitz
B
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D002467:Cell Nucleus / Q000648:ultrastructure; D004396:Coloring Agents; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D009392:Nephrectomy; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate; D014841:von Willebrand Factor / Q000032:analysis
D004396:Coloring Agents; D014841:von Willebrand Factor