title: [Scleroderma-like patch on the thigh in infants after vitamin K injection at birth: six observations].
abstract: BACKGROUND
  Texier's disease or pseudosclerodermatous reaction after intramuscular injection of vitamin K1 is well known in adults although only 1 report of a case in a newborn was found in the literature. We report 6 cases.
  
  
  METHODS
  Six infants (4 boys, 2 girls) developed "peau d'orange" skin lesions after the age of 6 months which was localized in the lower third of the medial aspect of the thigh. Initial rapid locoregional extension was followed by stabilization and then regression. In all 6 cases, histology showed lesions of the fascia and/or the deep hypoderma associated with variable mononuclear inflammatory infiltration and hyalin fibrosis. When performed, immunological studies (complement fixation, search for autoantibodies) were always negative or normal. No visceral involvement was found.
  
  
  CONCLUSIONS
  A pseudosclerodermatous lesion of the lower third of the thigh occurred in 6 infants at the site of an intramuscular injection of vitamin K1 administered at birth. The history, clinical manifestations, histology and outcome of these cases are compatible with the diagnosis of Texier's disease. We discuss the role of the solvent in the Roche vitamin K1 injection. The pathogenesis of this side effect remains unknown.
  
  
  CONCLUSIONS
  Texier's disease in infants after injection of vitamin K1 at birth is a stereotypic dermatosis. Diagnosis is based on history and clinical presentation. The causal effect of injectable vitamin K1 should be entertained whenever pseudosclerodermatous lesions are observed in a young child.
authors.affiliation: Service de Dermatologie, Hôpital Saint-Louis, Paris.
authors.forename: E
authors.initials: E
authors.lastname: Bourrat
authors.forename: I
authors.initials: I
authors.lastname: Moraillon
authors.forename: M D
authors.initials: MD
authors.lastname: Vignon-Pennamen
authors.forename: S
authors.initials: S
authors.lastname: Fraitag
authors.forename: B
authors.initials: B
authors.lastname: Cavelier-Balloy
authors.forename: F
authors.initials: F
authors.lastname: Cordoliani
authors.forename: A
authors.initials: A
authors.lastname: Bourillon
authors.forename: M
authors.initials: M
authors.lastname: Larrègue
authors.forename: P
authors.initials: P
authors.lastname: Morel
authors.forename: M
authors.initials: M
authors.lastname: Rybojad
mesh_terms: D000933:Antifibrinolytic Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000473:pathology; D013848:Thigh; D010837:Vitamin K 1 / Q000009:adverse effects*
chemical_list: D000933:Antifibrinolytic Agents; D010837:Vitamin K 1
vernacular_title: Placard sclérodermiforme de la cuisse de l'enfant après injection de vitamine K1 à la naissance: six observations.