title: A new ancient irrigation therapy for childhood renal candidiasis.
abstract: Methylene blue (MB) alone, MB metabolites in the urine and the effect of MB plus alkalization on Candida species were determined. MB was used for the treatment of childhood renal candidiasis (CRC) in 3 patients as an irrigating solution. Besides irrigation, fluconazole 3 mg/kg/day intravenously and MB 0.2 mg/kg/day were administered perorally. Urine cultures were cleared of Candida. DMSA scans obtained after 6 months showed no evidence of scarring. MB can be used for irrigation of the urinary tract, with fewer side effects than amphotericin B (AB). Additionally we advocate the use of ureteral catheters instead of nephrostomy in the treatment of CRC.
authors.affiliation: Department of Paediatric Surgery, Dokuz Eylül University, Medical Faculty, Izmir, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Aktug
authors.forename: M
authors.initials: M
authors.lastname: Olguner
authors.forename: F M
authors.initials: FM
authors.lastname: Akgür
authors.forename: C
authors.initials: C
authors.lastname: Aldirmaz
authors.forename: M
authors.initials: M
authors.lastname: Hoşgör
authors.forename: N
authors.initials: N
authors.lastname: Yulug
mesh_terms: D000284:Administration, Oral; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage; D002177:Candidiasis / Q000628:therapy*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000382:microbiology / Q000628:therapy*; D008297:Male; D008751:Methylene Blue / Q000008:administration & dosage*; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
chemical_list: D000892:Anti-Infective Agents, Urinary; D000935:Antifungal Agents; D015725:Fluconazole; D008751:Methylene Blue