[Itraconazole and secnidazole capsules vs. vaginal ovules of fluocinolone acetonide, nystatin and metronidazole in the symptomatic treatment of vaginitis].
OBJECTIVE
Evaluation of oral treatment in vaginitis and vaginosis using Itraconazol and sechidazol, in comparison to topic treatment using vaginal ovules of acetonido of fluocinolona 0.50 mg, nistatina 100,000 U and metronidazol 500 mg.


METHODS
Longitudinal, prospective and open comparative study.


METHODS
Servicio de Reproducción Humana(Human Reproduction Department), Centro Médico Nacional "20 de Noviembre".


METHODS
Forty female patients, without any relevant differences in their general characteristics, chose diagnosis was vaginitis and vaginosis, who were medically treated through external consultation, divided in two groups of twenty each one. Group 1 oral treatment with itraconazol and secnidazol. Group 2 had topic treatment with fluocinolona, nistatina and metronidazol. All of the patients were controlled in seven and fourteen days time, in order to evaluate the intensity of their clinical symptomatology, as well as the efficacy in both ways of treatment.


RESULTS
Leukorrhea was the most important symptom in all the cases, going from minor to serious white discharge. After the treatment, we found a relevant difference statistically significative in patients treated with intraconazol and secnidazol. We did not find any differences in relation to ardor, pruritus, dispareunia and disuria at post-treatment evaluation. However, group 1 betterment was statistically significative between the first and the seventh days of treatment.


CONCLUSIONS
Treating vaginitis or vaginosis (or both) with itraconazol and secnidazol takes less time for betterment in addition to comfort and easiness of oral administration; therefore, we consider them proper medicines in these specific cases.
Alvarado García
A
A
Gaviño Ambriz
S
S
D000981:Antiprotozoal Agents / Q000627:therapeutic use; D000994:Antitrichomonal Agents / Q000627:therapeutic use; D005260:Female; D005446:Fluocinolone Acetonide / Q000627:therapeutic use*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008795:Metronidazole / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D009761:Nystatin / Q000627:therapeutic use*; D014627:Vaginitis / Q000188:drug therapy*
D000981:Antiprotozoal Agents; D000994:Antitrichomonal Agents; D005446:Fluocinolone Acetonide; D009761:Nystatin; D008795:Metronidazole; D017964:Itraconazole; C016724:secnidazole
Itraconazol + Secnidazol cápsulas Vs. óvulos vaginales Acetónido de Fluocinolona 0.50 mg, Nistatina 100,000 U y Metronidazol 500 mg en el tratamiento sintomático de la vaginitis.