[Iodine-125 implantation in localized prostate cancer; technique and results from 100 patients at the Academic Hospital, Utrecht].
OBJECTIVE
To evaluate the preliminary results of perineal implantation of I-125 seeds in patients with cancer of the prostate.


METHODS
Prospective descriptive cohort study.


METHODS
Utrecht University Hospital, the Netherlands.


METHODS
In the period from October 1989 to December 1996, a total of 149 patients with localized carcinoma of the prostate were treated with perineal implantation of I-125 seeds. One hundred of them could be evaluated. Results regarding progression and complications were collected prospectively.


RESULTS
The median follow-up was 3 years (range 12-74 months). Progression of the disease was observed in 28 patients: local in eight, distant in four and both local and distant in one; 15 patients only showed a rise of prostate specific antigen level, without further symptoms. Fourteen patients were given supplementary treatment. No major complications were seen; four patients had persistent micturition problems and three, intestinal problems.


CONCLUSIONS
Perineal I-125 implantation causes few complications and may constitute an alternative to external irradiation as well as to radical prostatectomy in the treatment of localized carcinoma of the prostate.
Battermann
J J
JJ
Afd. Radiotherapie, Academisch Ziekenhuis, Utrecht.
Zeijlemaker
B Y
BY
D001918:Brachytherapy / Q000009:adverse effects* / Q000379:methods*; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D009362:Neoplasm Metastasis; D010502:Perineum; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis / Q000532:radiotherapy*; D012074:Remission Induction; D013223:Statistics as Topic; D015996:Survival Rate; D016896:Treatment Outcome
D007457:Iodine Radioisotopes; D017430:Prostate-Specific Antigen
Jodium-125-implantatie bij gelokaliseerd prostaatcarcinoom; techniek en resultaten bij 100 patiënten in het Academisch Ziekenhuis Utrecht.