title: 99mTc Tetrofosmin imaging in breast tumours.
abstract: Eighty-five women, 18 to 80 years of age, with palpable breast lumps were studied 1-4 days before surgery in order to evaluate 99mTc Tetrofosmin imaging for the detection of malignant breast tumours. Intravenous injection of 99mTc Tetrofosmin was followed by 3 min planar images at 5-60 min postinjection. In the latter 57 patients, planar imaging was preceded by a dynamic study of 20x5 sec images. The myocardium was always included in the field of the left breast. Count rates in suspicious areas were compared with normal tissue areas in the same and the opposite breast and with myocardial counts. Data analysis showed that 77 of the 85 scan results were in agreement with the histological findings; six scans were false negative and two false positive for malignancy. The sensitivity of the method was 90.32% and the specificity 91.30%, with a positive predictive value of 96.55%. We conclude that breast scanning with 99mTc Tetrofosmin may play an important role in the detection of breast malignancies.
authors.affiliation: B'Propedeutic Department of Surgery, Medical School-University of Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Markopoulos
authors.forename: F
authors.initials: F
authors.lastname: Sampalis
authors.forename: C
authors.initials: C
authors.lastname: Zerva
authors.forename: D
authors.initials: D
authors.lastname: Kiriaki
authors.forename: E
authors.initials: E
authors.lastname: Kitsou
authors.forename: V
authors.initials: V
authors.lastname: Alevizou-Terzaki
authors.forename: J
authors.initials: J
authors.lastname: Gogas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin