[Influence of polyethylene oxide Polyox WSR-301 on the pressure in mesenteric arterial microvessels in rats pre-adapted to anti-orthostatic states].
High-molecular polymers apt to directly influence flow microstructure were tested as a fundamentally new method for correcting microhemodynamics in microgravity. Pressure in the mesenteric arterial microvessels was measured two weeks in rats adapted to the head-down suspension. Intravenous polyethylene oxide (Polyox WSR-301, end-concentration in the order of 2.10(-7) g/ml), reduced the microvascular pressure by 26%, whereas in the control pressure was reduced by only 15%. Systemic arterial pressure showed an equal drop in the groups (by 10 to 11%). These results suggest that the biomechanical agent weakens resistance to the blood flow in the body region where blood supply is impaired by microgravity.
Grigorian
S S
SS
Sokolova
I A
IA
Shakhnazarov
A A
AA
Rudneva
R I
RI
Timkina
M I
MI
D000223:Adaptation, Psychological; D000818:Animals; D006439:Hemodynamics / Q000187:drug effects; D007024:Hypotension, Orthostatic; D008638:Mesenteric Arteries / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014893:Weightlessness
D011108:Polymers; C098305:Polyox WSR-301; D011092:Polyethylene Glycols
Vliianie poliétilenoksida Polyox WSR-301 na davlenie v arterial'nykh mikrososudakh bryzheĭki krys, predvaritel'no adaptirovannykh k antiortostaticheskim usloviiam.