Insulin sensitivity, sodium-lithium countertransport and platelet free calcium concentrations in normotensive men with a family history of hypertension.
Peripheral glucose disposal (assessed with the euglycaemic-hyperinsulinaemic clamp technique), Na+-Li+ countertransport in erythrocytes and the cytosolic free Ca2+ concentration in platelets were determined in 36 men from families with essential hypertension in at least two close relatives and in 28 age- and weight-matched men from families without hypertension. All had diastolic blood pressure consistently below 90 mm Hg and a normal oral glucose tolerance test. The mean age of the study population as a whole was 37 years (range 24-46). Insulin sensitivity index values (glucose disposal/serum insulin concentration during the clamp) were lower in the familial hypertension group than in the control group, but the two groups did not differ in Na+-Li+-countertransport, or in the platelet cytosolic free Ca2+ concentration which was correlated to the waist: hip circumference ratio in both groups (r = 0.38 and r = 0.49, respectively). The present findings do not support the hypothesis that an increase in Na+-Li+ countertransport activity or the platelet cytosolic free Ca2+ concentration is a marker of insulin resistance in hypertension prone men.
Mattiasson
I
I
Department of Medicine, Lund University, University Hospital, Malmö, Sweden.
Endre
T
T
Berglund
G
G
Hulthén
U L
UL
D000328:Adult; D017920:Antiporters / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values
D017920:Antiporters; D007328:Insulin; C045885:sodium-lithium countertransporter; D002118:Calcium