[Matrix metalloproteinases and their biological functions].
Matrix metalloproteases (MMPs) play a key role in the metabolism of connective tissue proteins in the norm and in pathology. Major MMP subfamilies (collagenases, gelatinases, and stromelysins) and matrixins, which have not been attributed to any subfamily, are reviewed. The main characteristics of these enzymes; their structural properties; their specificity; the regulation of their activity; and their role in the normal development of the matrix, the oncogenic transformation of the cell, and angiogenesis are discussed.
Solov'eva
N I
NI
Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D017364:Collagenases / Q000737:chemistry / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018093:Gelatinases / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D053506:Matrix Metalloproteinase 10; D053507:Matrix Metalloproteinase 11; D019278:Matrix Metalloproteinase 3 / Q000737:chemistry / Q000378:metabolism; D008666:Metalloendopeptidases / Q000737:chemistry / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology; D013379:Substrate Specificity
D004791:Enzyme Inhibitors; D017364:Collagenases; D018093:Gelatinases; D053507:Matrix Metalloproteinase 11; D008666:Metalloendopeptidases; D019278:Matrix Metalloproteinase 3; D053506:Matrix Metalloproteinase 10
Matriksnye metalloproteinazy i ikh biologicheskie funktsii.