title: An inactivated gE-negative marker vaccine and an experimental gD-subunit vaccine reduce the incidence of bovine herpesvirus 1 infections in the field.
abstract: An inactivated glycoprotein E-negative vaccine and an experimental glycoprotein D-subunit vaccine against bovine herpesvirus 1 (V1) were examined for their effectiveness in a randomized, double-bline, placebo-controlled field trial comprising 130 dairy farms. The use of these marker vaccines enabled us to monitor the incidence of infections in vaccinated populations. The aims of this trial were to evaluate whether these vaccines: (1) reduce the proportion of outbreaks in dairy herds; and (2) reduced virus transmission within dairy herds and to what extent. Vaccination with either of the two vaccines significantly reduced the proportion of herds wherein an outbreak occurred as well as the virus transmission within herds, as compared to placebo-treated herds. The estimated number of secondary cases caused by one infectious animal, expressed as the reproduction ratio R, was for both vaccines significantly > 1. This indicates that when BHV1 is introduced into vaccinated herds, major outbreaks may still occur.
authors.affiliation: Holland Genetics, Arnhem, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Bosch
authors.forename: M C
authors.initials: MC
authors.lastname: De Jong
authors.forename: P
authors.initials: P
authors.lastname: Franken
authors.forename: K
authors.initials: K
authors.lastname: Frankena
authors.forename: J J
authors.initials: JJ
authors.lastname: Hage
authors.forename: M J
authors.initials: MJ
authors.lastname: Kaashoek
authors.forename: M A
authors.initials: MA
authors.lastname: Maris-Veldhuis
authors.forename: J P
authors.initials: JP
authors.lastname: Noordhuizen
authors.forename: W H
authors.initials: WH
authors.lastname: Van der Poel
authors.forename: J
authors.initials: J
authors.lastname: Verhoeff
authors.forename: K
authors.initials: K
authors.lastname: Weerdmeester
authors.forename: G M
authors.initials: GM
authors.lastname: Zimmer
authors.forename: J T
authors.initials: JT
authors.lastname: Van Oirschot
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000008:administration & dosage* / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D005260:Female; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D014611:Vaccination; D014759:Viral Envelope Proteins / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D014765:Viral Vaccines; C046998:bovine herpesvirus type-1 glycoproteins