Treatment of hemoglobin Bart's hydrops with bone marrow transplantation.
A 21-month-old girl with hemoglobin Bart's hydrops received bone marrow transplantation (BMT) from a matched sibling. No major BMT-related complications developed. Hemoglobin levels remained greater than 10 gm/dl for 20 months without blood transfusion support despite the presence of residual host hemopoietic cells from 2 months after BMT. We suggest consideration of this therapeutic option for surviving patients.
Chik
K W
KW
Department of Pediatrics, Prince of Wales Hospital, Chinese University of Hong Kong.
Shing
M M
MM
Li
C K
CK
Leung
T F
TF
Tsang
K S
KS
Yuen
H L
HL
Cheng
S B
SB
Yuen
P M
PM
D016026:Bone Marrow Transplantation; D005260:Female; D005914:Globins / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics; D006801:Humans; D007223:Infant; D019172:Transplantation Conditioning; D017085:alpha-Thalassemia / Q000097:blood / Q000235:genetics / Q000628:therapy*
D006455:Hemoglobins, Abnormal; D005914:Globins; C030448:hemoglobin Bart's