title: Genome-wide search for genes affecting the risk for alcohol dependence.
abstract: Alcohol dependence is a leading cause of morbidity and premature death. Several lines of evidence suggest a substantial genetic component to the risk for alcoholism: sibs of alcoholic probands have a 3-8 fold increased risk of also developing alcoholism, and twin heritability estimates of 50-60% are reported by contemporary studies of twins. We report on the results of a six-center collaborative study to identify susceptibility loci for alcohol dependence. A genome-wide screen examined 291 markers in 987 individuals from 105 families. Two-point and multipoint nonparametric linkage analyses were performed to detect susceptibility loci for alcohol dependence. Multipoint methods provided the strongest suggestions of linkage with susceptibility loci for alcohol dependence on chromosomes 1 and 7, and more modest evidence for a locus on chromosome 2. In addition, there was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.
authors.affiliation: Department of Psychiatry, Washington University, St. Louis, Missouri 63110, USA.
authors.forename: T
authors.initials: T
authors.lastname: Reich
authors.forename: H J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: A
authors.initials: A
authors.lastname: Goate
authors.forename: J T
authors.initials: JT
authors.lastname: Williams
authors.forename: J P
authors.initials: JP
authors.lastname: Rice
authors.forename: P
authors.initials: P
authors.lastname: Van Eerdewegh
authors.forename: T
authors.initials: T
authors.lastname: Foroud
authors.forename: V
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: M A
authors.initials: MA
authors.lastname: Schuckit
authors.forename: K
authors.initials: K
authors.lastname: Bucholz
authors.forename: B
authors.initials: B
authors.lastname: Porjesz
authors.forename: T K
authors.initials: TK
authors.lastname: Li
authors.forename: P M
authors.initials: PM
authors.lastname: Conneally
authors.forename: J I
authors.initials: JI
authors.lastname: Nurnberger
authors.forename: J A
authors.initials: JA
authors.lastname: Tischfield
authors.forename: R R
authors.initials: RR
authors.lastname: Crowe
authors.forename: C R
authors.initials: CR
authors.lastname: Cloninger
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Shears
authors.forename: K
authors.initials: K
authors.lastname: Carr
authors.forename: C
authors.initials: C
authors.lastname: Crose
authors.forename: C
authors.initials: C
authors.lastname: Willig
authors.forename: H
authors.initials: H
authors.lastname: Begleiter
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D002877:Chromosomes, Human / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D012307:Risk Factors
chemical_list: D005819:Genetic Markers