[Changes in reactivity of the contractile system of the small intestine caused by disturbed parasympathetic innervation].
We studied the role of parasympathetic division of vegetative nervous system in regulation of the intestine activity in rats subjected to bilateral subdiaphragmal vagotomy, the response of the neuromuscular apparatus of the small intestine to stimulation by aceclydine taken as an example. Intravenous injection of aceclydine (0.5 mg/kg) into intact animals is accompanied by characteristics changes in the electrical and contractile activities of the intestine, which reflect its enhanced motor activity. Vagotomy leads to changes of response of the intestine to pharmacological stimulation, most expressed within 3, 7, and 30 days. It was proposed that distortion of reactive properties of the intestine contractile system under these conditions is related to functional changes in rhythm-setting neurons of intramural ganglia and M-cholinoreceptors of neuromuscular synapses.
Tsibulevskiĭ
A Iu
AIu
Russian State Medical University, Moscow, Russia.
Khripun
A I
AI
Ettinger
A P
AP
Dubovaia
T K
TK
Polivoda
M D
MD
Pen'kov
L Iu
LIu
D000818:Animals; D004594:Electrophysiology; D007421:Intestine, Small / Q000187:drug effects / Q000294:innervation* / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation* / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D010277:Parasympathomimetics / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology; D051381:Rats; D014628:Vagotomy
D010277:Parasympathomimetics; D011812:Quinuclidines; C084650:aceclidine
Izmenenie reaktivnosti sokratitel'nogo apparata tonkoĭ kishki v usloviiakh narushennoĭ parasimpaticheskoĭ innervatsii.