title: The use of a transverse CT image for the estimation of the dose given to the rectum in intracavitary brachytherapy for carcinoma of the cervix.
abstract: OBJECTIVE
  The three-dimensional (3D) dose distribution in combination with 3D anatomy of 13 patients treated for cervical carcinoma with intracavitary brachytherapy was analyzed. The aim of this study was to determine the correlation between a dose value obtained from the integral dose volume histogram (DVH) of the rectum and (a) the Nederlands Kanker Instituut (NKI) point of reference for the rectum dose (R) and (b) the highest dose to the frontal rectum wall in the transverse CT slice near the top of the vagina through point R.
  
  
  RESULTS
  The correlation between the DVH rectum dose value for 2 cm3 in the highest dose region and the rectum dose at point R was poor (regression coefficient 0.50). On the contrary, however, the correlation between the DVH rectum dose value for 2 cm3 in the highest dose region and the maximum rectum dose value in a transverse CT slice through point R was good (regression coefficient 0.90).
  
  
  CONCLUSIONS
  The maximal rectum dose value obtained from a transverse CT slice near the top of the vagina through point R was found to be a more representative point for the rectal dose burden and might therefore show a good correlation with complications. The point of reference for the rectal dose (R) was found not to be a reliable estimation of the maximal dose in the rectum.
authors.affiliation: Radiation Oncology Department, Groningen University Hospital, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: van den Bergh
authors.forename: H
authors.initials: H
authors.lastname: Meertens
authors.forename: L
authors.initials: L
authors.lastname: Moonen
authors.forename: B
authors.initials: B
authors.lastname: van Bunningen
authors.forename: A
authors.initials: A
authors.lastname: Blom
mesh_terms: D001918:Brachytherapy / Q000379:methods; D005260:Female; D006801:Humans; D011829:Radiation Dosage; D011879:Radiotherapy Dosage; D012007:Rectum / Q000000981:diagnostic imaging* / Q000528:radiation effects; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*