[The role of p53 gene in programmed cell death].
The gene coding for p53, a suppressor of malignant growth, is induced by various stress factors that cause appearance of the hereditarily pathologic cells. One of important p53 functions is initiation of apoptosis that eliminates potentially dangerous cells from the organism. The mechanism of p53-induced apoptosis are reviewed.
Chumakov
P M
PM
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
D000818:Animals; D017209:Apoptosis / Q000235:genetics* / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016158:Genes, p53 / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology
D016159:Tumor Suppressor Protein p53
Rol' gena p53 v programmirovannoí kletochnoĭ smerti.