title: Contribution of the ICE family to neurodegeneration.
abstract: The ICE family of cysteine proteases mediates necrotic or apoptotic events in the nervous system as well as in other tissues. This suggests that inhibitors may be of therapeutic value in acute and, perhaps, chronic neurodegenerative disease. In addition, some members of this family may respond to intercellular signals controlling proliferation or differentiation. This possibility should be kept in mind as therapeutics are pursued.
authors.affiliation: Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105, USA. Shiverb@aa.wl.com
authors.forename: B D
authors.initials: BD
authors.lastname: Shivers
authors.forename: P A
authors.initials: PA
authors.lastname: Boxer
authors.forename: K M
authors.initials: KM
authors.lastname: Keane
authors.forename: N C
authors.initials: NC
authors.lastname: Kupina
authors.forename: T
authors.initials: T
authors.lastname: Lynch
authors.forename: G P
authors.initials: GP
authors.lastname: Schielke
authors.forename: M G
authors.initials: MG
authors.lastname: Vartanian
authors.forename: J P
authors.initials: JP
authors.lastname: Vasilakos
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D020170:Caspase 1; D003546:Cysteine Endopeptidases / Q000502:physiology*; D006801:Humans; D009336:Necrosis; D009410:Nerve Degeneration / Q000503:physiopathology*
chemical_list: D003546:Cysteine Endopeptidases; D020170:Caspase 1