title: POLINA: detection and evaluation of single amino acid substitutions in protein superfamilies.
abstract: RESULTS
  An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program.
  
  
  BACKGROUND
  A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.h tml.
  
  
  BACKGROUND
  slevin@aecom.yu.edu; bsatir@aecom.yu.edu
authors.affiliation: Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. slevin@aecom.yu.edu
authors.forename: S
authors.initials: S
authors.lastname: Levin
authors.forename: B H
authors.initials: BH
authors.lastname: Satir
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D003196:Computer Graphics; D017124:Conserved Sequence; D005189:False Positive Reactions; D006454:Hemoglobins / Q000235:genetics; D006801:Humans; D017354:Point Mutation; D016415:Sequence Alignment; D012984:Software
chemical_list: D006454:Hemoglobins