title: Intragenic recombinations in rotaviruses.
abstract: In this paper, evidence for intragenic recombination in the VP7 gene between rotavirus strains bearing different serotypes is demonstrated for the first time. Intragenic recombination may be one of the escaping mechanisms from the host immune system for rotavirus. This process involves exchanging antigenic regions, thus questioning the use of multivalent vaccines for the prevention of rotavirus infection.
authors.affiliation: Department of Microbiology, Akita University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Gojobori
authors.forename: O
authors.initials: O
authors.lastname: Nakagomi
mesh_terms: D000956:Antigens, Viral; D002213:Capsid / Q000235:genetics*; D036022:Capsid Proteins; D005814:Genes, Viral / Q000235:genetics; D010802:Phylogeny; D011995:Recombination, Genetic; D012401:Rotavirus / Q000235:genetics*; D016415:Sequence Alignment; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus; D015678:Viral Structural Proteins