title: X-ray studies of enzymes that interact with penicillins.
abstract: The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic mechanisms of penicillin-binding proteins and beta-lactamases. An insight into the structural basis for antibiotic resistance is given.
authors.affiliation: Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Kelly
authors.forename: A P
authors.initials: AP
authors.lastname: Kuzin
authors.forename: P
authors.initials: P
authors.lastname: Charlier
authors.forename: E
authors.initials: E
authors.lastname: Fonzé
mesh_terms: D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D018360:Crystallography, X-Ray; D006602:Hexosyltransferases; D008958:Models, Molecular; D002267:Muramoylpentapeptide Carboxypeptidase / Q000737:chemistry / Q000378:metabolism*; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000737:chemistry / Q000378:metabolism*; D010458:Peptidyl Transferases; D014961:X-Ray Diffraction / Q000379:methods; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D001618:beta-Lactamases