Induction of cytochromes P4502B1/2B2 by some antiepileptic drugs in rat liver.
The effects of phenobarbital (PB), carbamazepine (CBZ) and diazepam (DZ) on total hepatic cytochrome P450, cytochromes P4502B1/2B2 contents and aminopyrine N-demethylase activity was investigated. Adult male rats were treated per os with PB (80 mg/kg/day), CBZ (75 mg/kg/day) or DZ (90 mg/kg/day) for 3 consecutives days. Carbamazepine and phenobarbital produced significant increase of the contents of total cytochrome P450 and cytochromes P4502B1/2B2 as well as aminopyrine N-demethylase activity. In contrast, diazepam decreased the total hepatic cytochrome P450 content. This drug did not affect the level of cytochromes P4502B1/2B2 but increased aminopyrine N-demethylase activity comparing to the control animals.
Kobylińska
K
K
Department of Biochemistry and Clinical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Poland.
Pachecka
J
J
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001189:Aryl Hydrocarbon Hydroxylases; D019362:Cytochrome P-450 CYP2B1 / Q000096:biosynthesis*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D003975:Diazepam / Q000494:pharmacology; D004790:Enzyme Induction; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013250:Steroid Hydroxylases / Q000096:biosynthesis*
D000927:Anticonvulsants; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; D019362:Cytochrome P-450 CYP2B1; C025619:steroid 16-beta-hydroxylase; D003975:Diazepam; D010634:Phenobarbital