Twin zygosity testing for medical purposes.
After being poisoned by eating the mushroom species Cortinarius speciosissimus, a twin developed interstitial nephritis with acute renal failure. He received a renal transplant from his living twin brother, who was presumed dizygotic on phenotypic grounds. Fifteen years later, the twins were zygosity tested by DNA "fingerprint analysis" and found to be monozygotic, despite important phenotypic discordances. The recipient has discontinued immunosuppression therapy and remains well after 9 months. We suggest that, for medical and other reasons, zygosity should be determined at birth on all like-sexed twins.
St Clair
D M
DM
Medical Research Council, Human Genetics Unit, Edinburgh, Scotland.
St Clair
J B
JB
Swainson
C P
CP
Bamforth
F
F
Machin
G A
GA
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D016172:DNA Fingerprinting; D003937:Diagnosis, Differential; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics*