title: [Uveitis, arthralgia and pseudo-jaundice in a HIV seronegative patient due to rifabutin].
abstract: Rifabutin is an effective drug in the treatment of Mycobacterium avium complex (MAC). Rare adverse effects have been described in non immunocompromised patients. We report the case of a 35 year-old woman, negative for the human immunodeficiency virus (HIV), who had an isolated pulmonary infection caused by MAC. Under Rifabutin (600 mg/day), Clarithromycin and Ethambutol, an uveitis, associated with a pseudojaundice and polyarthralgia, appeared, while pulmonary infection improved. Improvement of adverse effects was obtained with non-steroid anti-inflammatory drugs, local steroid treatment for uveitis and lower doses of Rifabutin (300 mg/day). Those adverse effects have not been previously described with this dose of Rifabutin in a non HIV patient. The mechanism remained unknown. The decrease of Rifabutin doses associated with symptomatic treatments allow the preservation of an effective treatment for MAC infection.
authors.affiliation: Service de Pneumologie et Immuno-allergologie, Hôpital Albert-Calmette, Lille.
authors.forename: P M
authors.initials: PM
authors.lastname: Ramon
authors.forename: I
authors.initials: I
authors.lastname: Tillie-Leblond
authors.forename: P
authors.initials: P
authors.lastname: Labalette
authors.forename: B
authors.initials: B
authors.lastname: Wallaert
authors.forename: A B
authors.initials: AB
authors.lastname: Tonnel
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000008:administration & dosage; D018771:Arthralgia / Q000139:chemically induced*; D017291:Clarithromycin / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004977:Ethambutol / Q000008:administration & dosage; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D007565:Jaundice / Q000139:chemically induced*; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy; D017828:Rifabutin / Q000008:administration & dosage / Q000009:adverse effects*; D014605:Uveitis / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D017828:Rifabutin; D004977:Ethambutol; D017291:Clarithromycin
vernacular_title: Uvéite, arthralgies et pseudo-jaunisse chez une patiente séronégative pour le VIH traitée par rifabutine.