Gene therapy for liver tumors.
The liver is a common site of metastases from solid tumors and the primary site for a number of malignancies. Cure rates for primary and metastatic liver tumors are low. Gene therapy is a novel approach to liver cancer that seeks to exploit differences between tumor cells and hepatocytes to achieve tumor eradication with preservation of normal hepatic parenchyma. Numerous strategies for tumor specific cytolysis are reviewed.
Carroll
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NM
Division of Surgical Oncology, Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Tanabe
K K
KK
D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*