title: Effect of mammographic breast density on breast cancer screening performance: a study in Nijmegen, The Netherlands.
abstract: OBJECTIVE
  To study the implications of breast density on mammographic screening performance.
  
  
  METHODS
  Screening outcomes of women with dense breast patterns were compared with those of women with lucent breast patterns (dense > 25% densities, lucent < or = 25% densities); the women were screened in different periods (before/after improvement of the mammographic technique in 1982).
  
  
  METHODS
  Nijmegen, the Netherlands, 1977-1994.
  
  
  METHODS
  Between 1977 and 1994, 73,525 repeat screenings were performed in 19,152 participants (aged 50-69 years) in the Nijmegen breast cancer screening programme (repeat screenings were defined as mammographic examinations that were preceded by an examination in the previous screening round). Participants were screened biennially with mammography. There were 258 screen detected and 145 interval cancers.
  
  
  RESULTS
  Before 1982 (rounds 2-4) the predictive value of a positive screening test (PV+) was lower in women with dense breasts than in those with lucent breasts (dense 29% v lucent 52%, p = 0.003). Also, the ratio of screen detected cancers to the total number of screen detected plus interval cancers (as a proxy for sensitivity) was lower in this group (based on a one year interval: dense 63% v lucent 92%, p = 0.001 and based on a two year interval: dense 41% v lucent 68%, p = 0.002). Moreover, the survival rate was less favourable for those with dense breasts (p = 0.07). In rounds 5-10, there were no important differences with respect to PV+ (dense 66% v lucent 62%, p = 0.57) or survival (p = 0.48). Moreover, sensitivity based on a one year interval was nearly as high in women with dense breasts as in those with lucent breasts (85% v 86%, p = 0.75). However, based on a two year interval sensitivity was lower (dense 59% v lucent 72%, p = 0.04).
  
  
  CONCLUSIONS
  In the early screening years (rounds 2-4) high breast density had an unfavourable effect on screening performance. Nowadays, the situation has improved with respect to PV+, survival and detecting tumours in dense breasts with a lead time of up to one year, but little improvement has occurred in the detection of tumours with a lead time greater than one year.
authors.affiliation: Department of Epidemiology, University of Nijmegen, The Netherlands.
authors.forename: C H
authors.initials: CH
authors.lastname: van Gils
authors.forename: J D
authors.initials: JD
authors.lastname: Otten
authors.forename: A L
authors.initials: AL
authors.lastname: Verbeek
authors.forename: J H
authors.initials: JH
authors.lastname: Hendriks
authors.forename: R
authors.initials: R
authors.lastname: Holland
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008327:Mammography / Q000592:standards*; D008403:Mass Screening / Q000592:standards*; D008875:Middle Aged; D009367:Neoplasm Staging; D009426:Netherlands / Q000453:epidemiology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015996:Survival Rate