Effect of cytokines on anticryptococcal activity of human microglial cells.
The effect of selected cytokines on the antifungal activity of human microglia was studied with encapsulated and acapsular strains of Cryptococcus neoformans. None of the cytokines tested increased the fungistatic activity of microglia, suggesting that killing of cryptococci within the central nervous system is dependent on other host defense mechanisms.
Lipovsky
M M
MM
Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, Minnesota, USA.
Juliana
A E
AE
Gekker
G
G
Hu
S
S
Hoepelman
A I
AI
Peterson
P K
PK
D003455:Cryptococcus neoformans / Q000254:growth & development / Q000276:immunology*; D003470:Culture Media; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D017628:Microglia / Q000276:immunology* / Q000382:microbiology
D003470:Culture Media; D016898:Interferon-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor