[Bilirubin-albumin binding in term newborns on total parenteral nutrition].
We evaluate the influence of plasma lipid levels supplied in parenteral nutrition, on the bilirubin-albumin binding of 12 term newborns with severe pathologies. As controls we selected 2 groups of an equal number o newborns who were receiving maternal or artificial lactation. The reserved albumin binding capacity decreased in newborns subjected to parenteral nutrition (52.3 versus 72.9/73.5). This decrease correlated positively with greater concentrations of free fatty acids (r = 0.9234, p < 0.001), cholesterol (r = 0.9049, p < 0.001), and triglycerides (r = 0.8802, p < 0.001). The clear influence of the studied lipid parameters on the bilirubin albumin binding, invites us to consider the systematic use of heparin for the mobilization of lipoprotein-lipase from the vascular endothelium and to promote a better management of lipids in term newborns, especially if there is an important hyperbilirubinemia.
Domínguez Ortega
F
F
Servicio de Neonatología, Hospital Materno-Infantil, Facultad de Medicina, Universidad de las Palmas de G. C., España.
González Azpeitia
G
G
Domenech Martínez
E
E
D000368:Aged; D000704:Analysis of Variance; D001663:Bilirubin / Q000378:metabolism*; D001942:Breast Feeding; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D008962:Models, Theoretical; D010289:Parenteral Nutrition, Total; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D001663:Bilirubin
Unión bilirrubina-albúmina en recién nacidos a término sometidos a nutrición parenteral total.