title: Locoregional approaches to therapy with gliomas as the paradigm.
abstract: Most malignant gliomas recur locally, despite the fact that these tumors are usually found to be diffusely infiltrating on pathologic studies. Thus, efforts have concentrated on local disease control as an initial step to improve the prognosis of these patients. This review discusses the most recent studies on locoregional approaches in therapy for this poor-prognosis neoplasm. Emphasis is placed on the radiotherapeutic and combined modality (radiotherapy and chemotherapy) approaches reported during the past year.
authors.affiliation: University of Vermont College of Medicine, Department of Medicine, Burlington 05405, USA.
authors.forename: B C
authors.initials: BC
authors.lastname: Liang
authors.forename: M
authors.initials: M
authors.lastname: Weil
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005910:Glioma / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D006931:Hyperbaric Oxygenation; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use; D011867:Radioisotope Teletherapy; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D011838:Radiation-Sensitizing Agents