title: Three- to 5-year prospective follow-up of outcome in major depression.
abstract: BACKGROUND
  A Dutch cohort of predominantly out-patient DSM-III-R major depressive patients was followed for 3 to 5 years after start of treatment in a psycho-neuro-endocrinological prediction study. The study design permitted description of the course of remissions, relapses and recurrences.
  
  
  METHODS
  Pharmacological treatment was standardized, psychotherapy was tailored to the needs of the patient, follow-ups were done monthly until 3 years or more after the initial recruitment.
  
  
  RESULTS
  After 9 months 49% of the patients had reached full remission and 45% were in partial remission. During the following 3 to 5 years 82% of the patients had reached a period of full remission. Sixteen per cent of the patients needed 2 years or more before full remission. A relapse or recurrence rate of 41% within 5 years was found. Patients with residual symptoms relapsed particularly in the first 4 months after remission, while patients without residual symptoms recurred mainly after 12 months after remission. Previous depressive episodes and psychoticism predicted relapse. Psychomotor retardation at inception predicted a longer time to partial remission.
  
  
  CONCLUSIONS
  In most cases, major depression is a seriously impairing episodic disease. This is also true for a sample of predominantly out-patients treated at a university clinic.
authors.affiliation: Department of Psychiatry, Leiden University, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Van Londen
authors.forename: R P
authors.initials: RP
authors.lastname: Molenaar
authors.forename: J G
authors.initials: JG
authors.lastname: Goekoop
authors.forename: A H
authors.initials: AH
authors.lastname: Zwinderman
authors.forename: H G
authors.initials: HG
authors.lastname: Rooijmans
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents