Synteny mapping of four genes from the short arm of human chromosome 19 to bovine chromosome 7.
Four genes on the short arm of human chromosome 19 (HSA 19p) were assigned to bovine chromosome 7 (BTA 7) using a bovine x rodent somatic hybrid cell panel. These four genes were cartilage oligomeric matrix protein (COMP), lymphoblastic leukemia derived sequence 1 (LYL1), lysosomal alpha-mannosidase (MANB), and RAS oncogene family member RAB3A. Bovine sequence tagged sites were developed for the four genes and used for screening a bovine x rodent somatic cell panel. All four genes were mapped to bovine synteny group U22 (BTA 7) with a correlation coefficient of 0.901-1.000. This study confirms that the centromeric region of BTA 7 is conserved with HSA 19p.
Gu
Z X
ZX
Department of Animal Sciences, University of Wisconsin-Madison, 53706, USA.
Womack
J E
JE
Kirkpatrick
B W
BW
D000818:Animals; D002356:Cartilage; D064236:Cartilage Oligomeric Matrix Protein; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D002888:Chromosomes, Human, Pair 19; D016326:Extracellular Matrix Proteins; D011905:Genes, ras; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics; D008361:Mannosidases / Q000235:genetics; D064235:Matrilin Proteins; D016324:Sequence Tagged Sites; D043323:alpha-Mannosidase
D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; C577553:TSP5 protein, human; D008361:Mannosidases; D043323:alpha-Mannosidase