title: Effect of omeprazole on the pharmacokinetics of itraconazole.
abstract: OBJECTIVE
  To investigate the effect of omeprazole on the pharmacokinetics of itraconazole.
  
  
  METHODS
  Eleven healthy volunteers received a single dose of oral itraconazole (200 mg) on days 1 and 15 and oral omeprazole (40 mg) once daily from day 2 to day 15. Itraconazole pharmacokinetics were studied on days 1 and 15.
  
  
  RESULTS
  Concentrations of itraconazole were higher when it was taken alone than when it was taken with omeprazole. With concomitant omeprazole treatment, the mean AUC0-24 and Cmax of itraconazole were significantly reduced by 64% and 66%, respectively.
  
  
  CONCLUSIONS
  Omeprazole affects itraconazole kinetics, leading to a reduction in bioavailability and Cmax. These two drugs should not be used together.
authors.affiliation: Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Jaruratanasirikul
authors.forename: S
authors.initials: S
authors.lastname: Sriwiriyajan
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D004347:Drug Interactions; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D012016:Reference Values
chemical_list: D000897:Anti-Ulcer Agents; D000935:Antifungal Agents; D017964:Itraconazole; D009853:Omeprazole