title: Adult T-cell leukemia-lymphoma successfully treated with 2-chlorodeoxyadenosine.
abstract: Adult T-cell leukemia-lymphoma (ATL) is resistant to currently available chemotherapy and has a poor prognosis. We describe here a patient with ATL successfully treated with 2-chlorodeoxyadenosine (2-CdA). A 75-year-old Japanese male with an acute type of ATL, who had become resistant to the initial cytotoxic chemotherapy, was treated with 2-CdA administered by continuous drip infusion of 0.09 mg/kg/d for seven consecutive days in one month (one cycle). After three cycles of treatment, partial remission (PR) was achieved. Surprisingly, 249 days after the administration of 2-CdA, ATL cells completely disappeared from the peripheral blood. PR was maintained during 10 weeks until evidence of a new lymphadenopathy. No remarkable toxicity of 2-CdA occurred.
authors.affiliation: Department of Hematology, National Kyushu Cancer Center, Fukuoka.
authors.forename: N
authors.initials: N
authors.lastname: Uike
authors.forename: I
authors.initials: I
authors.lastname: Choi
authors.forename: A
authors.initials: A
authors.lastname: Tokoro
authors.forename: T
authors.initials: T
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Yufu
authors.forename: M
authors.initials: M
authors.lastname: Kozuru
authors.forename: K
authors.initials: K
authors.lastname: Tobinai
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017338:Cladribine / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local
chemical_list: D000970:Antineoplastic Agents; D017338:Cladribine