title: Ossification of the posterior longitudinal ligament in Down's syndrome.
abstract: Cervical myelopathy in patients with Down's syndrome is not uncommonly the result of atlanto-axial instability, a condition that is caused by ligamentous laxity and which may be associated with congenital osseous anomalies at the occipito-atlanto-axial axis. Ossification of the posterior longitudinal ligament (OPLL) is well described, particularly in the Japanese population, and may be associated with diffuse idiopathic skeletal hyperostosis. This is the first case, to our knowledge, of OPLL occurring in a person with Down's syndrome presenting with myelopathy.
authors.affiliation: Department of Diagnostic Imaging, The Institute of Orthopaedics, The Robert Jones and Agnes Hunt Orthopaedic and District Hospital, Oswestry, Shropshire, UK.
authors.forename: P N
authors.initials: PN
authors.lastname: Tyrrell
authors.forename: V N
authors.initials: VN
authors.lastname: Cassar-Pullicino
authors.forename: I W
authors.initials: IW
authors.lastname: McCall
mesh_terms: D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017887:Ossification of Posterior Longitudinal Ligament / Q000150:complications* / Q000175:diagnosis*; D013117:Spinal Cord Compression / Q000209:etiology; D014057:Tomography, X-Ray Computed