title: An early systolic sound associated with midventricular obstruction in a patient with hypertrophic cardiomyopathy.
abstract: A 57-year-old woman was admitted for examination because of chest discomfort. Transthoracic echocardiography was performed and she was diagnosed as having hypertrophic cardiomyopathy. An echocardiogram also revealed that she had midventricular obstruction with a pressure gradient of 125 mmHg determined by Doppler echocardiography. A phonocardiogram showed an early systolic sound and the beginning of the sound coincided with the time of septal-posterior wall contact. In addition, the timing also corresponded to the sudden obstruction of blood flow in the region of the midventricular narrowing. Furthermore, this sound markedly decreased with the reduction in pressure gradient caused by cibenzoline treatment. Thus, it was concluded that the early systolic sound was associated with midventricular obstruction and produced by a rapid deceleration of the interventricular flow caused by midventricular obstruction.
authors.affiliation: Second Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohtsuka
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: Y
authors.initials: Y
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Kuwahara
authors.forename: K
authors.initials: K
authors.lastname: Kodama
authors.forename: Y
authors.initials: Y
authors.lastname: Shigematsu
authors.forename: T
authors.initials: T
authors.lastname: Iwata
authors.forename: K
authors.initials: K
authors.lastname: Hiwada
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications*; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D006347:Heart Sounds / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D008875:Middle Aged; D010701:Phonocardiography; D013599:Systole; D013997:Time Factors; D014694:Ventricular Outflow Obstruction / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; C032151:cifenline