title: Analysis of the origin of the extra chromosome in trisomy 8 in 4 cases of spontaneous abortions.
abstract: OBJECTIVE
  To determine the origin of the extra chromosome in trisomy 8 in spontaneous abortions.
  
  
  METHODS
  We analyzed 4 cases of nonmosaic trisomy 8 in 1st-trimester spontaneous abortions and their parents with DNA polymorphism analysis using microsatellite DNA markers.
  
  
  RESULTS
  In 3 cases the extra chromosome was maternal in origin and in 1 case paternal in origin. In 2 of the cases the nondisjunction had occurred in maternal meiosis, while the other 2 cases were consistent with a postzygotic (mitotic) origin of the additional chromosome.
  
  
  CONCLUSIONS
  Although a small number of cases studied, these results suggest differences from the common autosomal trisomies 21, 18, 16, and 13 where the vast majority of cases are due to errors in maternal meiosis.
authors.affiliation: Mitera Maternity Hospital, Athens, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Nicolaidis
authors.forename: G
authors.initials: G
authors.lastname: von Beust
authors.forename: M
authors.initials: M
authors.lastname: Bugge
authors.forename: G
authors.initials: G
authors.lastname: Karadima
authors.forename: D
authors.initials: D
authors.lastname: Vassilopoulos
authors.forename: K
authors.initials: K
authors.lastname: Brøndum-Nielsen
authors.forename: M B
authors.initials: MB
authors.lastname: Petersen
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8; D005220:Fathers; D005260:Female; D006801:Humans; D008540:Meiosis; D018895:Microsatellite Repeats; D008938:Mitosis; D009035:Mothers; D009630:Nondisjunction, Genetic; D011110:Polymorphism, Genetic; D011247:Pregnancy; D014314:Trisomy