title: [Improvement of effectiveness of antibiotic therapy by pyrimidine derivatives in reparative regeneration of skin in rats].
abstract: It was shown on noninbred albino rats with various affections of the skin that pyrimidine derivatives stimulated the skin reparative regeneration and increased the efficacy of antibiotic therapy of Staphylococcus and Proteus infected wounds. The therapeutic effect of 2-methyl-4-amino-6-oxypyrimidine was much higher than that of oxymethyluracil or methyluracil. The pyrimidine derivatives proved to be universal accelerators for reparative regeneration, were compatible with antibiotics and increased their efficacy.
authors.affiliation: Institute of Organic Chemistry, Ufa Scientific Centre, Russian Academy of Sciences.
authors.forename: A F
authors.initials: AF
authors.lastname: Ismagilova
authors.forename: F S
authors.initials: FS
authors.lastname: Zarudiĭ
authors.forename: D N
authors.initials: DN
authors.lastname: Lazareva
authors.forename: V A
authors.initials: VA
authors.lastname: Davydova
authors.forename: L T
authors.initials: LT
authors.lastname: Karachurina
authors.forename: Z F
authors.initials: ZF
authors.lastname: Ismagilova
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Tropynina
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004357:Drug Synergism; D011512:Proteus Infections / Q000188:drug therapy*; D011743:Pyrimidines / Q000627:therapeutic use*; D051381:Rats; D012867:Skin / Q000187:drug effects*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000188:drug therapy*
chemical_list: C113629:2-methyl-4-amino-6-oxypyrimidine; D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D014498:Uracil; C008378:6-methyluracil; C003029:oxymethacil
vernacular_title: Povyshenie éffektivnosti antibiotikoterapii proizvodnymi pirimidina pri reparativnoĭ regeneratsii kozhi u krys.