title: Aluminum alters intracellular calcium homeostasis in vitro.
abstract: The present paper reports data regarding the influence of aluminum, at micromolar concentrations, on intracellular calcium homeostasis. Al3+ modifies Ca2+ uptake in the endoplasmic reticulum (ER), accelerates Ca2+ release from mitochondria and strongly inhibits Ca2+-ATPase activity with a consequent high-level calcium accumulation inside the cell. These results suggest that Al3+ neurotoxicity may be related to an alteration of the intracellular calcium regulatory system.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Padova, Padova, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Gandolfi
authors.forename: M P
authors.initials: MP
authors.lastname: Stella
authors.forename: P
authors.initials: P
authors.lastname: Zambenedetti
authors.forename: P
authors.initials: P
authors.lastname: Zatta
mesh_terms: D000535:Aluminum / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry; D005456:Fluorescent Dyes / Q000378:metabolism; D006706:Homeostasis; D007424:Intracellular Fluid / Q000201:enzymology / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism; D009930:Organic Chemicals; D051381:Rats; D017208:Rats, Wistar; D019284:Thapsigargin / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D005456:Fluorescent Dyes; D009930:Organic Chemicals; C071336:calcium green; D019284:Thapsigargin; D000535:Aluminum; D000252:Calcium-Transporting ATPases; D002118:Calcium