Combination of ABO blood group incompatibility and glucose-6-phosphate dehydrogenase deficiency: effect on hemolysis and neonatal hyperbilirubinemia.
The incidence (%) of hyperbilirubinemia (serum bilirubin > or = 257 micromol/l) was similar in neonates with a combination of ABO incompatibility and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency (45%), with ABO incompatibility (54%) or G-6-PD deficiency (37%), alone (ns). Carboxyhemoglobin values, corrected for inspired CO, were similarly elevated in all three groups (0.87 +/- 0.32%, 0.82 +/- 0.29%, 0.76 +/- 0.18%, respectively, ns), but correlated with bilirubin only in those with ABO incompatibility alone. ABO-incompatible/G-6-PD-deficient neonates, compared with those with either condition alone, are not at increased risk for hemolysis or hyperbilirubinemia.
Kaplan
M
M
Department of Neonatology, Shaare Zedek Medical Center, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
Vreman
H J
HJ
Hammerman
C
C
Leiter
C
C
Rudensky
B
B
MacDonald
M G
MG
Stevenson
D K
DK
D000017:ABO Blood-Group System; D001787:Blood Group Incompatibility / Q000097:blood / Q000150:complications*; D002263:Carboxyhemoglobin / Q000378:metabolism; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood / Q000150:complications*; D006461:Hemolysis; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood / Q000209:etiology*; D008297:Male
D000017:ABO Blood-Group System; D002263:Carboxyhemoglobin