Liver transplantation for disulfiram-induced hepatic failure.
Fulminant hepatitis is a rare but potentially fatal adverse reaction that may occur after the use of disulfiram. A patient without a known history of liver disease was transplanted for fulminant hepatic failure secondary to disulfiram. A high index of suspicion and aggressive therapeutic approaches are essential for the prompt diagnosis and treatment of disulfiram-induced hepatic failure. The clinical presentation, histopathology, treatment, and all cases of disulfiram-induced hepatic failure reported in the English literature are reviewed. The role of orthotopic liver transplantation in a case of disulfiram-induced hepatic failure is discussed.
Rabkin
J M
JM
Department of Surgery, Oregon Health Sciences University and Portland Veterans Affairs Medical Center, USA.
Corless
C L
CL
Orloff
S L
SL
Benner
K G
KG
Flora
K D
KD
Rosen
H R
HR
Olyaei
A J
AJ
D000328:Adult; D000427:Alcohol Deterrents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000601:surgery; D004221:Disulfiram / Q000009:adverse effects*; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000601:surgery*; D006801:Humans; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation; D008297:Male
D000427:Alcohol Deterrents; D004221:Disulfiram