title: The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis.
abstract: The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda > or = 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to determine whether this is a true or false-positive finding. It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis.
authors.affiliation: Wellcome Trust Centre for Human Genetics, Headington, Oxford.
authors.forename: M A
authors.initials: MA
authors.lastname: Brown
authors.forename: M
authors.initials: M
authors.lastname: Rudwaleit
authors.forename: K D
authors.initials: KD
authors.lastname: Pile
authors.forename: L G
authors.initials: LG
authors.lastname: Kennedy
authors.forename: J
authors.initials: J
authors.lastname: Shatford
authors.forename: C I
authors.initials: CI
authors.lastname: Amos
authors.forename: K
authors.initials: K
authors.lastname: Siminovitch
authors.forename: L
authors.initials: L
authors.lastname: Rubin
authors.forename: A
authors.initials: A
authors.lastname: Calin
authors.forename: B P
authors.initials: BP
authors.lastname: Wordsworth
mesh_terms: D005192:Family Health; D005260:Female; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009679:Nuclear Family; D011110:Polymorphism, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology*
chemical_list: D011948:Receptors, Antigen, T-Cell