Depletion of radiosensitive leukocytes exacerbates the heart sympathetic denervation and parasitism in experimental Chagas' disease in rats.
The acute phase of the Trypanosoma cruzi infection induces damage of the heart sympathetic nerve terminals in rats. The participation of the radiosensitive leukocytes in this process was assessed in young rats submitted to gamma irradiation 1 day before infection with T. cruzi, Y strain. Gamma irradiation increased the heart noradrenergic denervation evaluated at day 12 of infection by histochemical and electron-microscopic methods. The presence of numerous macrophages with ultrastructural features of activation and a significant rise in the myocardial parasitism suggest the involvement of radioresistant macrophages or parasite factors, or both, on the damage of the nerve terminals.
Melo
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Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. rmelo@icb.ufjf.br
Machado
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D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects; D002598:Chagas Cardiomyopathy / Q000276:immunology*; D005260:Female; D006325:Heart Atria / Q000294:innervation / Q000469:parasitology; D007111:Immunity, Cellular / Q000528:radiation effects; D007962:Leukocytes / Q000276:immunology / Q000469:parasitology / Q000528:radiation effects*; D008854:Microscopy, Electron; D009206:Myocardium / Q000166:cytology / Q000276:immunology / Q000648:ultrastructure; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000737:chemistry / Q000276:immunology* / Q000469:parasitology*
D009638:Norepinephrine