A ruggedness test strategy for procedure related factors: experimental set-up and interpretation.
A strategy to perform ruggedness tests for mainly procedure related factors is described. The different steps in the set-up of the experiments and in the interpretation of the results are given. The described strategy is based on a number of case studies and allows a statistical interpretation of the significance of the effects. It was implemented in a software tool. This original strategy was completed with a number of minimal screening designs which reduce the number of experiments to perform, but in consequence only allow a limited or no statistical interpretation of the effects. Some of the minimal designs are expandable to designs with characteristics similar to those of the original strategy.
Heyden
Y V
YV
Vrije Universiteit Brussel, ChemoAC, Pharmaceutical Institute, Brussels, Belgium.
Questier
F
F
Massart
D L
DL
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D012107:Research Design