Liver imaging with ferumoxides (Feridex): fundamentals, controversies, and practical aspects.
Superparamagnetic nanoparticles (Feridex) have been recently made available to the radiological community as a contrast agent for MR imaging of the liver. This article reviews the principal physicochemical characteristics of this new compound, with an emphasis on the explanation of the contrast obtained (either positive or negative enhancement) that depends on the local concentration and the sequence used. The clinical use of Feridex is detailed, both for lesion detection and characterization. Finally, some guidelines for image optimization are given.
Clément
O
O
Service de Radiologie, Hôpital Laënnec, Paris, France.
Siauve
N
N
Cuénod
C A
CA
Frija
G
G
D003287:Contrast Media; D003911:Dextrans; D052203:Ferrosoferric Oxide; D006801:Humans; D007501:Iron / Q000493:pharmacokinetics; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D010087:Oxides / Q000493:pharmacokinetics; D013535:Suspensions
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D013535:Suspensions; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide