No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder.
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylase gene. A total of 118 bipolar, 125 unipolar, and 437 control subjects were used in the study (1:3.7 bipolar:control, 1:3.5 unipolar:control). There were no significant differences in TPH allele or genotype frequencies between the affective disorder and control groups. In addition, bipolar and/or unipolar subjects with or without a history of suicide attempts were compared for the TPH polymorphism. No significant differences were found between suicidal and non-suicidal groups in major affective disorder, in contrast to a previous study suggesting an association of this polymorphism with a history of suicide attempts among alcoholic violent offenders.
Furlong
R A
RA
Department of Medical Genetics, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
Ho
L
L
Rubinsztein
J S
JS
Walsh
C
C
Paykel
E S
ES
Rubinsztein
D C
DC
D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D019964:Mood Disorders / Q000201:enzymology / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D013406:Suicide, Attempted; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D014365:Tryptophan Hydroxylase