title: Can reactive airways dysfunction syndrome (RADS) transform into occupational asthma due to "sensitisation" to isocyanates?
abstract: The case history is described of a worker who presented with a history suggestive of reactive airways dysfunction syndrome which occurred after an acute high level inhalation of diphenylmethane diisocyanate. Further exposure at work, at a time when concentrations of isocyanates were no longer "irritant", suggested occupational asthma; this diagnosis was confirmed by a specific inhalation challenge test.
authors.affiliation: DEpartment of Chest Medicine, Hôpital du Sacré-Coeur, Gouin, Montréal Canada.
authors.forename: C
authors.initials: C
authors.lastname: Leroyer
authors.forename: L
authors.initials: L
authors.lastname: Perfetti
authors.forename: A
authors.initials: A
authors.lastname: Cartier
authors.forename: J L
authors.initials: JL
authors.lastname: Malo
mesh_terms: D000485:Allergens / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis; D001985:Bronchial Provocation Tests; D006801:Humans; D017953:Isocyanates / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D016273:Occupational Exposure / Q000009:adverse effects*; D012130:Respiratory Hypersensitivity / Q000139:chemically induced*; D001559:Benzhydryl Compounds
chemical_list: D000485:Allergens; D017953:Isocyanates; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds