title: Combined calcium and vitamin D supplementation reduces bone loss and fracture incidence in older men and women.
abstract: A recent supplementation study of 389 men and women, over the age of 65 years was conducted to address the impact of combined calcium and vitamin D supplementation on nonvertebral fracture incidence and maintenance of bone mass. Daily supplementation with 500 mg calcium and 700 IU vitamin D for 3 years moderately reduced bone loss at several sites and significantly decreased the rate of nonvertebral fractures, compared with a placebo group. Optimal intake of both calcium and vitamin D may be an easily implemented strategy to maintain existing bone mass and reduce the risk of fracture in older men and women.
authors.affiliation: Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205-2179, USA.
authors.forename: K O
authors.initials: KO
authors.lastname: O'Brien
mesh_terms: D000368:Aged; D000375:Aging; D002136:Calcium, Dietary / Q000008:administration & dosage*; D005260:Female; D050723:Fractures, Bone / Q000517:prevention & control*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D002136:Calcium, Dietary; D014807:Vitamin D