title: Evaluation of needle biopsy in the diagnosis of prostatic carcinoma in men with prostatic intraepithelial neoplasia.
abstract: Prostatic intraepithelial neoplasia (PIN) is considered a premalignant lesion of the prostate. It is often encountered in prostate needle biopsy in cases where no cancer is identified. In order to evaluate its importance 25 patients with PIN in a former prostate needle biopsy underwent a second ultrasound guided needle biopsy. The first biopsy was performed in all patients as a result of positive DRE. In 13 patients (52%), prostate cancer was identified in the second specimen. All presented with high or intermediate grade PIN in the first biopsy. PSA values were compared with PIN grade and cancer presentation in the second biopsy, although no statistically significant difference was proven. In conclusion, when PIN is discovered in prostate needle biopsy in patients with positive DRE, a second biopsy has to be performed in order to exclude the possibility of a prostate carcinoma.
authors.affiliation: Department of Urology, University of Athens, Sismanoglio Hospital, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Deliveliotis
authors.forename: G
authors.initials: G
authors.lastname: Louras
authors.forename: G
authors.initials: G
authors.lastname: Raptidis
authors.forename: S
authors.initials: S
authors.lastname: Giannakopoulos
authors.forename: J
authors.initials: J
authors.lastname: Kastriotis
authors.forename: A
authors.initials: A
authors.lastname: Kostakopoulos
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002277:Carcinoma / Q000097:blood / Q000473:pathology / Q000601:surgery*; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D019048:Prostatic Intraepithelial Neoplasia / Q000097:blood / Q000473:pathology / Q000601:surgery*; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology / Q000601:surgery*; D012086:Reoperation
chemical_list: D017430:Prostate-Specific Antigen