title: Cranberry extract inhibits low density lipoprotein oxidation.
abstract: Cranberry juice consumption is often used for the treatment of urinary tract infections, but the effect of cranberry juice on heart disease has not been investigated. We evaluated how a cranberry extract containing 1,548 mg gallic acid equivalents/liter (initial pH=2.50) affected low density lipoprotein (LDL) oxidation induced by 10 micromolar cupric sulfate. When LDL oxidation took place in the presence of diluted cranberry extracts, the formation of thiobarbituric acid reactive substances (TBARS) and LDL electrophoretic mobility were reduced. LDL electrophoretic migration was also reduced when the cranberry extract had a pH of 7.00 prior to dilution. This study suggests that cranberry extracts have the ability to inhibit the oxidative modification of LDL particles.
authors.affiliation: La Crosse Exercise and Health Program, University of Wisconsin-La Crosse, 54601, USA. wilso_ef@mail.uwlax.edu
authors.forename: T
authors.initials: T
authors.lastname: Wilson
authors.forename: J P
authors.initials: JP
authors.lastname: Porcari
authors.forename: D
authors.initials: D
authors.lastname: Harbin
mesh_terms: D000328:Adult; D001628:Beverages; D004587:Electrophoresis, Agar Gel; D005638:Fruit; D005707:Gallic Acid; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D008077:Lipoproteins, LDL; D017392:Thiobarbituric Acid Reactive Substances; D005707:Gallic Acid