title: Simultaneous administration of antithrombin III and protein C concentrates for the treatment of a devastating coagulopathy in a child.
abstract: Severe disseminated intravascular coagulation (DIC) is a rare event in childhood. We report here a young body with a devastating DIC unresponsive to heparin, fresh frozen plasma and platelet support. This prompted the use of antithrombin III and protein C concentrates and the effects of this combination were temporarily spectacular. We suggest that the simultaneous administration of two inhibitors of blood coagulation could be of interest and should be evaluated in appropriate trials for the treatment of a devastating coagulopathy.
authors.affiliation: Laboratoire d'Hématologie, Hôpital d'enfants Armand-Trousseau, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Favier
authors.forename: A
authors.initials: A
authors.lastname: Deschamps
authors.forename: R
authors.initials: R
authors.lastname: Belhocine
authors.forename: A
authors.initials: A
authors.lastname: Ankri
authors.forename: J
authors.initials: J
authors.lastname: Costil
authors.forename: P
authors.initials: P
authors.lastname: de Moerloose
mesh_terms: D000990:Antithrombin III / Q000627:therapeutic use*; D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008297:Male; D011486:Protein C / Q000627:therapeutic use*
chemical_list: D011486:Protein C; D000990:Antithrombin III