title: The combination of partial liquid ventilation and inhaled nitric oxide in the severe oleic acid lung injury model.
abstract: OBJECTIVE
  To elucidate the efficacy of the combination of inhaled nitric oxide (NO) and partial liquid ventilation (PLV) in ARDS.
  
  
  METHODS
  Prospective, randomized, controlled study.
  
  
  METHODS
  A research laboratory at a university medical center.
  
  
  METHODS
  Thirty-two rabbits.
  
  
  METHODS
  Animals were anesthetized and ventilated via tracheostomy (tidal volume=40 mL; respiratory rate=25 breaths/min; fraction of inspired oxygen=0.99). After 0.08 mL/kg (0.071 g/kg) oleic acid was administered via the central venous route, animals were randomly divided into the following four groups depending on the ventilatory mode: (1) Gas ventilation (GV)-control group: GV was continued throughout the study; (2) GV-NO group: NO inhalation (10 ppm) was performed under GV; (3) PLV-control group: PLV using perflubron (15 mL/kg) was continued until the end of the study; and (4) PLV-NO group: NO inhalation (10 ppm) was performed under PLV.
  
  
  RESULTS
  NO inhalation improved PaO2 in the PLV-NO group (from 133+/-20 to 167+/-23 mm Hg; p=0.0008), but not in the GV-NO group (from 67+/-6 to 63+/-9 mm Hg), although pulmonary vascular resistance decreased both in the GV-NO (from 4,604+/-328 to 4,337+/-322 dyne x s x cm(-5); p=0.0116) and the PLV-NO group (from 4,727+/-665 to 4,112+/-560 dyne x s x cm(-5); p=0.0036). (Data were expressed as mean+/-SEM.)
  
  
  CONCLUSIONS
  PLV augmented the effect of inhaled NO on pulmonary gas exchange. The combination of PLV and NO inhalation could be effective in severe ARDS.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Tokyo Medical and Dental University, School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: K
authors.initials: K
authors.lastname: Nakazawa
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: K
authors.initials: K
authors.lastname: Makita
authors.forename: K
authors.initials: K
authors.lastname: Amaha
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D005466:Fluorocarbons / Q000008:administration & dosage*; D006439:Hemodynamics; D006842:Hydrocarbons, Brominated; D009569:Nitric Oxide / Q000008:administration & dosage*; D019301:Oleic Acid; D010100:Oxygen / Q000097:blood; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D011817:Rabbits; D012121:Respiration, Artificial / Q000379:methods; D014655:Vascular Resistance
chemical_list: D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D002245:Carbon Dioxide; D019301:Oleic Acid; D009569:Nitric Oxide; C003072:perflubron; D010100:Oxygen