[Changes in the neuromediator system of the thymus in rats after splenectomy].
Removal of spleen leads to compensatory activation of the function of central immunogenetic organ and increase of hyperplastic processes in it on d 3 postoperatively which is accompanied by growth of biogenic amine concentration, appearance of bioaminergic areas and lobules-satellites as well as formation of new cloe correlative links. Transitory inhibition of immunogenesis occurs on d 15 and d 30 peaking on d 45 following splenectomy. At this period glycosaminoglycan composition of mast cells and their functional activity changes which is manifested by appearance of juvenile T-0 forms and new metachromatic types of mast cells. In 2 months decrease of APUD cells number and their mono- and diamine content and weakening of correlative interconnections is accompanied by true significant disturbance in T lymphocytes differentiation, their release in peripheral blood and further insufficiency of cellular immunity.
Struchko
G Iu
GIu
Department of Medical Biology and Histology, Medical Institute, Chuvash State University, Cheboksrary.
D001078:APUD Cells / Q000378:metabolism; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D008297:Male; D051381:Rats; D013154:Spleen / Q000502:physiology*; D013156:Splenectomy; D013950:Thymus Gland / Q000378:metabolism*; D013952:Thymus Hyperplasia / Q000378:metabolism
D015306:Biogenic Monoamines
Izmeneniia neĭromediatornoĭ sistemy timusa u krys posle splenectomy.