[Tumor invasion in gallbladder cancer. Importance of blood vascular tumor infiltration diagnosis].
BACKGROUND
The infiltration of venous blood vessels in gallbladder carcinoma and its importance as a prognostic factor has not been well studied. Victoria blue stain has been used to identify vascular involvement in gastric and thyroidal carcinomas.


OBJECTIVE
To assess blood vessel infiltration using Victoria blue stain in gallbladder carcinomas.


METHODS
One hundred forty eight samples of gallbladder carcinomas, coming from 24 men and 123 women aged 60.4 +/- 12.2 years old, were studied. They were stained with Victoria blue stain to quantify blood vessel invasion.


RESULTS
Twenty nine percent of tumors had blood vessel infiltration, 61% had lymph vessel and 20% had perineural infiltration. Lymph vessel or perineural involvement was found in 81% and 31% of those tumors with blood vessel infiltration, respectively. Perineural infiltration was associated with lymph or vascular involvement in 93 and 40% of tumors, respectively. None of the early carcinomas had blood vessel infiltration, whereas 33% of advanced tumors had this type of infiltration (p < 0.001). No differences in vascular infiltration were observed according to the differentiation of the tumor.


CONCLUSIONS
Blood vessel infiltration was observed only in advanced gallbladder carcinomas and was tightly related to the degree of gallbladder wall infiltration. The presence of perineural infiltration was the best marker of lymph or blood vessel infiltration.
Roa
I
I
Hospital Temuco, Facultad de Medicina, Universidad de la Frontera, Temuco, Chile.
Guzmán
P
P
Araya
J C
JC
Villaseca
M
M
Roa
J C
JC
Ibacache
G
G
de Aretxabala
X
X
García
M
M
D000230:Adenocarcinoma / Q000473:pathology*; D004396:Coloring Agents; D005260:Female; D005706:Gallbladder Neoplasms / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D019043:Vascular Neoplasms / Q000473:pathology*
D004396:Coloring Agents
Formas de invasión tumoral en el cáncer de la vesícula biliar. Importancia del diagnóstico de la infiltración tumoral vascular sanguínea.