Magnetic resonance spectroscopy in affective disorders.
Magnetic resonance spectroscopy (MRS) is a non-invasive tool for in vivo chemical analysis that has been applied to neurobiological or psychopharmacological studies of affective disorders. Studies employing 31P-MRS and 1H-MRS have indicated possible abnormalities in membrane phospholipid metabolism, high-energy phosphate metabolism, and intracellular pH in affective disorders. They have also suggested that lithium increases the phosphomonoester (possibly inositol-1-phosphate) peak in the brain but does not increase that of choline-containing compounds in the brain. Studies employing 7Li-MRS and 19F-MRS have elucidated the pharmacokinetic properties of lithium, fluoxetine, and fluvoxamine in the brain in patients treated with these drugs.
Kato
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T
Department of Psychiatry, Shiga University of Medical Science, Japan. tadafumi-tky@umin.ac.jp
Inubushi
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T
Kato
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N
D000339:Affect / Q000502:physiology; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000493:pharmacokinetics; D014150:Antipsychotic Agents / Q000494:pharmacology; D001479:Basal Ganglia / Q000187:drug effects / Q000378:metabolism; D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology; D004734:Energy Metabolism; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006859:Hydrogen; D008094:Lithium / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008563:Membrane Lipids / Q000378:metabolism; D019964:Mood Disorders / Q000188:drug therapy / Q000503:physiopathology*; D010761:Phosphorus Radioisotopes; D011868:Radioisotopes / Q000493:pharmacokinetics
D018687:Antidepressive Agents, Second-Generation; D014150:Antipsychotic Agents; D005462:Fluorine Radioisotopes; D008563:Membrane Lipids; D010761:Phosphorus Radioisotopes; D011868:Radioisotopes; D006859:Hydrogen; D008094:Lithium