title: [Rationale of noninvasive method of drug administration at the prelymphatic level].
abstract: The paper deals with the mode of local drug administration into the biological tissue at the prelympathic level without damaging the skin, which is based on enhancement of skin permeability by exposing to physical factors, including the use of contrast temperatures in the cyclic process of heating-cooling, followed by exposure to contact low-frequency ultrasound. Experimental and clinical studies of the mode versus routine drug administration have shown it to be promising in physiotherapeutic use.
authors.forename: V V
authors.initials: VV
authors.lastname: Pedder
authors.forename: V N
authors.initials: VN
authors.lastname: Grigor'ev
authors.forename: G Z
authors.initials: GZ
authors.lastname: Rot
authors.forename: V P
authors.initials: VP
authors.lastname: Afanas'ev
authors.forename: A A
authors.initials: AA
authors.lastname: Novikov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Letiagin
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Shkuro
mesh_terms: D000818:Animals; D004285:Dogs; D004333:Drug Administration Routes; D006801:Humans; D007478:Iontophoresis / Q000295:instrumentation; D008198:Lymph Nodes; D008208:Lymphatic System; D008833:Microcirculation; D008854:Microscopy, Electron; D015612:Phonophoresis / Q000295:instrumentation; D026741:Physical Therapy Modalities; D051381:Rats; D012212:Rheology; D012869:Skin Absorption; D013696:Temperature
vernacular_title: Obosnovanie neinvazivnogo metoda vvedeniia lekarstvennykh veshchestv na urovne prelimfaticheskogo zvena.