[Determination of prostate-specific antigen (PSA) in cytosol of breast tumors and human endometrium--new diagnostic approaches].
Prostate specific antigen is a highly specific marker of prostatic tissue. Recent studies have shown, that it is present in several other human tissues, tumors and fluids. PSA has been identified as a serine protease and member of the kallikrein family of enzymes. In our study PSA concentration was measured in 97 cytosols of breast cancer tissues and 14 samples, prepared from human endometrium. Cytosols were analysed also for steroid hormone receptors, EGF-receptor, Cathepsin D and pS-2 protein. PSA was found in 84.5% of breast cancer tissues and in 12 endometrium samples. High concentration of PSA were associated with high pS-2 protein levels. No correlation was found between the concentration of steroid hormone receptors and PSA in our material. The results suggest, that PSA in cytosol of human breast cancer and endometrial tissues may be an additional new prognostic indicator.
Seliger
E
E
Klinik und Poliklinik für Geburtshilfe und Reproduktionsmedizin, Martin-Luther-Universität Halle-Wittenberg.
Kaltwasser
P
P
Röpke
F
F
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000175:diagnosis; D003600:Cytosol / Q000737:chemistry*; D004717:Endometrium / Q000737:chemistry*; D005260:Female; D006801:Humans; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012016:Reference Values; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D017430:Prostate-Specific Antigen
Die Bestimmung des Prostata-spezifischen Antigens (PSA) im Zytosol von Mammatumoren und im humanen Endometrium--neue diagnostische Ansätze.