[Effect of kyotorphin on the seizure activity induced by kainic acid during picrotoxin kindling in rats].
In Wistar rats, the ED-50 of kainic acid induced clonic seizures. In early and postponed periods of kindling, the ED-50 decreased by 2,0 to 1.5 times. Kyotorphin did not affect the ED-50 of kainic acid in postponed periods.
Brusentsov
A I
AI
State Medical University, Odessa, Ukraine.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003292:Convulsants / Q000633:toxicity; D004723:Endorphins / Q000494:pharmacology*; D018690:Excitatory Amino Acid Agonists / Q000378:metabolism* / Q000633:toxicity; D007608:Kainic Acid / Q000378:metabolism* / Q000633:toxicity; D007696:Kindling, Neurologic; D008297:Male; D010852:Picrotoxin / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D000927:Anticonvulsants; D003292:Convulsants; D004723:Endorphins; D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid; D010852:Picrotoxin; C019448:kyotorphin
Vliianie kiotorfina na sudorozhnuiu aktivnost', vyzvannuiu kainovoĭ kislotoĭ pri pikrotoksinovom kindlinge u krys.