title: [Prevention of nitric oxide hyperproduction by adaptation to stressor effects].
abstract: As was shown earlier, acute hypotensive shock induced by nitrogen oxide (NO) hyperproduction can be prevented by dosed adaptation to environmental factors. In this work we tested the hypothesis that the mechanism of this adaptive effect is based on limiting NO hyperproduction. It was shown that rat adaptation to stress completely prevented arterial depression and sharply increased revival rate of the animals after heat shock. Hypotension induced by heat shock was accompanied by almost 2.5-fold increase in NO production (EPR analysis) as compared to the control. At the background of preadaptation, heat shock did not increase NO production relative to the animals not subjected to heat shock. The data obtained agree with the proposal that the adaptation initiates NO-dependent mechanisms of limiting NO hyperproduction. Such limiting seems to be negatively regulated by NO.
authors.affiliation: Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: E B
authors.initials: EB
authors.lastname: Manukhina
authors.forename: D A
authors.initials: DA
authors.lastname: Pokidyshev
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Malyshev
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Mashina
authors.forename: F
authors.initials: F
authors.lastname: Viegant
authors.forename: V D
authors.initials: VD
authors.lastname: Mikoian
authors.forename: L N
authors.initials: LN
authors.lastname: Kubrina
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D018869:Heat-Shock Response; D007022:Hypotension / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D007103:Immobilization; D008099:Liver / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D009569:Nitric Oxide
vernacular_title: Preduprezhdenie giperproduktsii oksida azota s pomoshch'iu adaptatsii k stressornym vozdeĭstviiam.