title: Blood pressure in adolescence and early adulthood related to obesity and birth size.
abstract: OBJECTIVE
  Obesity is an established risk factor for higher systolic (SBP) and diastolic (DBP) blood pressure in adolescence and early adulthood, but birth size may also have a role. We analyzed the effects of adolescent and adult obesity and birth size on BP in the young adult.
  
  
  METHODS
  In a prospective longitudinal study, anthropometric measurements were obtained at birth on 67 boys and 67 girls born in Boston. Their body mass indices (BMI) and BP were recorded 17 years and 30 years later.
  
  
  RESULTS
  For women, adolescent and early adult obesity appeared to be the stronger determinants of higher BP, although smaller head and chest circumferences at birth may also be related. We found some evidence of birth (ponderal index [PI] and head circumference) anthropometric influences on age 17 BP levels in boys. By age 30, body mass variables were the dominant predictors of male BP levels. Female BMI at age 17 was positively correlated with birth adiposity (PI), but BMI at 30 was related only to age 17 BMI. Similarly, male BMI at 17 years was higher for those who weighed more at birth, but BMI at 30 years was again related only to age 17 BMI.
  
  
  CONCLUSIONS
  We conclude that adult weight and weight gain are the major determinants of adult BP.
authors.affiliation: Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Berkey
authors.forename: J
authors.initials: J
authors.lastname: Gardner
authors.forename: G A
authors.initials: GA
authors.lastname: Colditz
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001724:Birth Weight; D001794:Blood Pressure; D001823:Body Composition; D001827:Body Height; D015992:Body Mass Index; D002508:Cephalometry; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D011446:Prospective Studies