title: Dobutamine stress echocardiography: false positive scans in proteinuric patients with type 1 diabetes mellitus at high risk of ischaemic heart disease.
abstract: Patients with Type 1 diabetes mellitus have an increased risk of ischaemic heart disease (IHD). When diabetes is complicated by nephropathy this risk is further increased and asymptomatic IHD is common. New techniques for non-invasive cardiac evaluation are now available and one of these, Dobutamine Stress Echocardiography (DSE), was studied in subjects with Type 1 DM and nephropathy who had no evidence of IHD. DSE was performed on 18 subjects (13 male, 5 female; mean age 37.8 +/- 3.4 years), diabetes duration 23.7 +/- 1.2 years and nephropathy diagnosed for 10.9 +/- 1.3 years. There were 7 (38%) positive scans-suggesting asymptomatic IHD; 16.7% of subjects studied had a significant arrhythmia. Coronary angiography was performed in 6 of the 7 subjects with positive DSEs and was positive in only 2. These results suggest that DSE has a high rate of false positive results in Type 1 DM patients suffering from nephropathy and may limit its usefulness in these subjects.
authors.affiliation: Department of Diabetes/Endocrinology, Mater Misericordiae Hospital, Dublin, Ireland.
authors.forename: M E
authors.initials: ME
authors.lastname: Griffin
authors.forename: K
authors.initials: K
authors.lastname: Nikookam
authors.forename: M M
authors.initials: MM
authors.lastname: Teh
authors.forename: H
authors.initials: H
authors.lastname: McCann
authors.forename: N M
authors.initials: NM
authors.lastname: O'Meara
authors.forename: R G
authors.initials: RG
authors.lastname: Firth
mesh_terms: D000328:Adult; D017023:Coronary Angiography; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000652:urine; D003928:Diabetic Nephropathies / Q000453:epidemiology; D004280:Dobutamine; D004452:Echocardiography / Q000379:methods*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D011507:Proteinuria / Q000150:complications; D012307:Risk Factors
chemical_list: D004280:Dobutamine