[Meningo-encephalitis and hydrocephalus caused by Epstein-Barr virus].
In a 35-year-old woman who presented with acute somnolence, confusion and slow irregular breathing, Epstein-Barr virus (EBV) meningoencephalitis was diagnosed after serological testing and a polymerase chain reaction of the cerebrospinal fluid. She developed papilloedema and bilateral nervus abducens paresis. A CT scan showed generalized oedema of the brain and triventricular hydrocephalus. Treatment with a ventriculoperitoneal shunt and ganciclovir led to complete recovery. Meningoencephalitis is a not uncommon, yet rarely reported complication of infectious mononucleosis. It usually runs a mild course with spontaneous and full recovery. Hydrocephalus secondary to aqueduct stenosis is a complication of Epstein-Barr virus (EBV) meningoencephalitis which has not been reported in adults before. The disease should be considered whenever the clinical condition deteriorates or neurological symptoms increase.
van der Klooster
J M
JM
Afd. Interne Geneeskunde en Intensive-caregeneeskunde, Sint Clara Ziekenhuis, Rotterdam.
van Saase
J L
JL
Grootendorst
A F
AF
Sinnige
H A
HA
D000328:Adult; D002555:Cerebrospinal Fluid / Q000821:virology*; D005260:Female; D006566:Herpesviridae Infections / Q000175:diagnosis*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid / Q000821:virology*; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000821:virology*; D016133:Polymerase Chain Reaction; D012698:Serologic Tests; D014412:Tumor Virus Infections / Q000175:diagnosis*
Meningo-encefalitis en hydrocefalus veroorzaakt door Epstein-Barr-virus.