Effects of azoxymethane on X-ray induced intestinal metaplasia in Donryu rats.
The present study was undertaken to determine the effect of azoxymethane (AOM) administration on intestinal metaplasia induced by X-irradiation in male Donryu rats. Five-week-old animals were X-irradiated with two doses of 10 Gy each at a 3-day interval or three X-ray doses of 10 Gy at a 2-day interval and then received AOM injections i.m. at a dose of 15 mg/kg body weight once weekly for 3 weeks, 6 months after irradiation. Alkaline phosphatase positive foci were decreased after AOM treatments, but aberrant crypt like-foci appeared within areas of intestinal metaplasia. In contrast no induction was observed in normal-appearing gastric mucosa.
Watanabe
H
H
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima, 734-8553, Japan.
Fujimoto
N
N
Masaoka
Y
Y
Kurosumi
M
M
Oguri
T
T
Takahashi
T
T
Kido
S
S
Hirata
S
S
Kuramoto
K
K
Shoji
S
S
Katoh
O
O
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001397:Azoxymethane / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D007422:Intestines / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D008297:Male; D008679:Metaplasia / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D000469:Alkaline Phosphatase; D001397:Azoxymethane