[Content and composition of lipoproteins of rat blood and liver and various parameters of oxidative stress during administration of cobalt chloride].
Cobalt chloride effect on rat liver and serum blood lipoproteins content and composition and on some characteristics of lipid peroxidation and oxidative stress was investigated. The activation of free-radical oxidation and oxidative stress development were judged from the dynamics of lipid peroxidation products accumulation, from cathepsin D unsedimental activity and from the alteration of microsomal cytochrome P-450 content and from activity of a number antioxidative enzymes. In order to evaluate the state of glutathione-defence system the activities of glutathione peroxidase, glutathione S-transferase, glutathione reductase and some NADPH-generating enzymes and reduced glutathione level alteration were studied in liver. The data obtained show that the cobalt chloride injection leads to the development of the oxidative stress and to activation of some antioxidant defence system, namely, glutathione-depending enzymes, and of microsomal cytochrome P-450 catabolism. The system blood lipoproteins (liver lipoproteins was found to participate in metabolism adaptation under oxidative stress and in maintenance of biological membranes structure and functioning.
Kaliman
P A
PA
Kharkov State University.
Zagaĭko
A L
AL
Shalamov
R V
RV
Ganusova
G V
GV
Barannik
T V
TV
Skripnik
E V
EV
Sokolik
V V
VV
Shabi
B K
BK
D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D005609:Free Radicals; D008074:Lipoproteins; D003035:Cobalt; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; C018021:cobaltous chloride; D005978:Glutathione
Soderzhanie i sostav lipoproteinov krovi i pecheni krys i nekotorye pokazateli okislitel'nogo stressa pri vvedenii khlorida kobal'ta.