title: Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives.
abstract: A series of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diesters substituted at the N-1 and/or C-4 positions of the dihydropyridine ring was synthesized. The in vitro cytotoxicity and in vitro and in vivo radioprotective efficacy of these agents were evaluated in Chinese hamster (V-79) cells and CD2F1 male mice, respectively. Compounds with at least one adamantyl substituent afforded better radioprotection than those without this substituent. Substitution of an aromatic ring at the C-4 position of the dihydropyridine ring did not enhance the radioprotectant action of the compounds.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis 38163, USA.
authors.forename: I O
authors.initials: IO
authors.lastname: Donkor
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: Schmidt
authors.forename: K C
authors.initials: KC
authors.lastname: Agrawal
authors.forename: V
authors.initials: V
authors.lastname: Kishore
mesh_terms: D000218:Adamantane / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D004095:Dihydropyridines; D011837:Radiation-Protective Agents; C038806:1,4-dihydropyridine; D000218:Adamantane