[The action of sodium oxybutyrate and emoxypin on the functional state of the adrenaline-damaged myocardium in an experiment].
The effect of agents possessing antihypoxic and antioxidant activity, namely sodium oxybutyrate and emoxypin, on the functional state of the heart muscle was studied in experiments on dogs with epinephrine necroses of the myocardium. A marked cardioprotective effect was produced by sodium oxybutyrate infused intravenously (200 mg/kg) either 10 min or 2 hrs after myocardial damage had been modelled and by emoxypin (4 mg/kg; 0.4 mg/kg) infused intravenously 30 min after the damage.
Sysoliatina
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Institute of Veterinary Medicine, Agrarian University, Omsk, Russia.
Artamonova
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VV
D000322:Adrenergic Agonists; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000188:drug therapy* / Q000201:enzymology; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine; D005260:Female; D008297:Male; D010847:Picolines / Q000627:therapeutic use*; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013997:Time Factors
D000322:Adrenergic Agonists; D000975:Antioxidants; D002317:Cardiovascular Agents; D010847:Picolines; D012978:Sodium Oxybate; C009820:6-methyl-2-ethyl-3-hydroxypyridine; D004837:Epinephrine
Deĭstvie natriia oksibutirata i émoksipina na funktsionnal'noe sostoianie povrezhdennogo adrenalinom miokarda v éksperimente.