title: Iontophoretic transdermal delivery of salbutamol: methyl-orange ion-pair.
abstract: The influence of pulsed current duty cycle, addition of electrically neutral species and pH on iontophoretic transdermal delivery of an organic ion-pair salbutamol:methyl orange through excised rabbit abdominal skin is described. It was compared with salbutamol sulphate and salbutamol:sulphate ion-pair. It was found that there exists an optimum duty cycle range (1:3-1:4) at which iontophoretic flux of the ion-pair was at a maximum because of partition-electric current synchronization. Addition of mannitol decreases the flux of the ion-pair showing the important role of electroosmosis in ion-pair transport. The extremes of pH decrease the flux rates.
authors.affiliation: Bharati Vidyapeeth's Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India.
authors.forename: V P
authors.initials: VP
authors.lastname: Sant
authors.forename: A J
authors.initials: AJ
authors.lastname: Khopade
authors.forename: N K
authors.initials: NK
authors.lastname: Jain
mesh_terms: D000279:Administration, Cutaneous; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D000420:Albuterol / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D001391:Azo Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D007474:Ion Exchange; D007478:Iontophoresis; D008353:Mannitol / Q000737:chemistry; D010539:Permeability; D011817:Rabbits; D012869:Skin Absorption
chemical_list: D000317:Adrenergic alpha-Antagonists; D001391:Azo Compounds; D007202:Indicators and Reagents; D008353:Mannitol; C100258:methyl orange; D000420:Albuterol