title: Plasma pyridoxine deficiency is related to increased psychological distress in recently bereaved homosexual men.
abstract: OBJECTIVE
  Previous research has demonstrated that a theoretical model including measures of life stressors, social support, and coping style significantly predicts psychological distress. This study tested plasma pyridoxine (vitamin B6) deficiency status as a predictor of overall psychological distress and specific mood states in this model, controlling for HIV-1 serostatus.
  
  
  METHODS
  Subjects included HIV-1+ (N = 76) and HIV-1- (N = 58) recently bereaved homosexual men. At baseline, subjects completed a battery of psychosocial questionnaires, together with a physical examination and venipuncture. The Profile of Mood States (POMS) provided measures of overall psychological distress as well as specific mood states. Pyridoxine deficiency status (a categorical measure of deficient vs. adequate status) was determined with a bioassay of erythrocyte aspartate aminotransferase activity.
  
  
  RESULTS
  Pyridoxine deficiency was a significant predictor of increased overall psychological distress in this model, controlling for life stressors, social support, coping style, and HIV-1 serostatus. In post hoc analyses of specific mood state effects, pyridoxine deficiency status was significantly associated with increases in depressed, fatigued, and confused mood levels, but not with those of anxiety, anger, or vigor.
  
  
  CONCLUSIONS
  These findings suggest that adequate pyridoxine status may be necessary to avert psychological distress in the setting of bereavement. Inasmuch as pyridoxine is a cofactor for 5-hydroxytryptophan decarboxylase--an enzyme in the biosynthesis pathway of serotonin--serotonin level in the brain is implicated as the mediating factor.
authors.affiliation: Department of Psychology, University of Miami School of Medicine, Florida 33136, USA.
authors.forename: T
authors.initials: T
authors.lastname: Baldewicz
authors.forename: K
authors.initials: K
authors.lastname: Goodkin
authors.forename: D J
authors.initials: DJ
authors.lastname: Feaster
authors.forename: N T
authors.initials: NT
authors.lastname: Blaney
authors.forename: M
authors.initials: M
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: G
authors.initials: G
authors.lastname: Shor-Posner
authors.forename: M
authors.initials: M
authors.lastname: Baum
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology; D000328:Adult; D000339:Affect / Q000502:physiology; D001601:Bereavement; D003863:Depression / Q000097:blood / Q000523:psychology; D006679:HIV Seropositivity / Q000097:blood / Q000523:psychology*; D015497:HIV-1; D018451:Homosexuality, Male / Q000523:psychology*; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D011736:Pyridoxine / Q000097:blood*; D013315:Stress, Psychological / Q000097:blood / Q000150:complications*; D026681:Vitamin B 6 Deficiency / Q000097:blood / Q000523:psychology*
chemical_list: D011736:Pyridoxine