[Thrombin--a regulator of reparative processes in wound healing].
Thrombin, binding to receptors of the protease activated receptor (PAR) family, is involved in wound healing by inducing the reparation processes and regulating the activity of mast cells, which secrete mediators of inflammation. Using thrombin receptor agonist peptide (TRAP-6) for the activation of rat mast cells, effect of several receptors, including PAR-1, on mast cells was demonstrated. It was shown that TRAP increases the concentration of Ca2+ in the cytoplasm of mast cells and regulates cell degranulation, while releasing nitrogen oxide. Thrombin encapsulated in poly(N-vinyl caprolactam)-calcium alginate (PVCL-Ca-Alg) hydrogel films promotes wound healing in rats as demonstrated by the acceleration of fibroblast proliferation and neovascularization.
Strukova
S M
SM
Department of Human and Animal Physiology, Moscow State University, Russia.
Dugina
T N
TN
Chistov
I V
IV
Markvicheva
E A
EA
Kuptsova
S V
SV
Kolokol'chikova
E G
EG
Rumsh
L D
LD
Zubov
V P
VP
Gluza
E
E
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002209:Caprolactam / Q000031:analogs & derivatives / Q000737:chemistry; D015550:Cell Degranulation / Q000187:drug effects; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D004339:Drug Compounding; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009569:Nitric Oxide / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry; D051381:Rats; D018179:Receptors, Thrombin / Q000819:agonists*; D013917:Thrombin / Q000502:physiology*; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
D010446:Peptide Fragments; D011108:Polymers; D018179:Receptors, Thrombin; C082835:thrombin receptor peptide (42-47); C086861:poly-N-vinylcaprolactam; D009569:Nitric Oxide; D002209:Caprolactam; D013917:Thrombin; D002118:Calcium
Trombin--reguliator reparativnikh protsessov pri zazhivlenii ran.