title: [Acute hepatic necrosis in a patient treated with cyproterone acetate].
abstract: The Authors report a case of prostatic carcinoma in a 84 year old male, treated with cyproterone acetate (CPA), complicated by a fatal fulminant hepatitis. He was admitted with a mixed jaundice followed by a derange of all liver function tests. Serological markers for hepatitis were negative. Ultrasonography and CT revealed no hepatic abnormality but gallstones and dilatation of principal bile duct with a terminal stricture. By the endoscopic retrograde cholangiography and sphincterotomy we put an external drain tube. He died 9 days after admission. Fatal hepatis due to CPA is a very rare complication but all patients on anti-androgenic drugs should have liver function closely monitored. CPA must be discontinued immediately at the first derange of liver function tests.
authors.affiliation: Istituto di IV Clinica Chirurgica, Università degli Studi La Sapienza, Roma.
authors.forename: A
authors.initials: A
authors.lastname: Lombardi
authors.forename: P
authors.initials: P
authors.lastname: Ferrazza
authors.forename: F
authors.initials: F
authors.lastname: Castaldi
authors.forename: L
authors.initials: L
authors.lastname: Covotta
authors.forename: A
authors.initials: A
authors.lastname: Tesoriere
authors.forename: V
authors.initials: V
authors.lastname: Urbano
authors.forename: G
authors.initials: G
authors.lastname: Midiri
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D002760:Cholangiopancreatography, Endoscopic Retrograde; D017373:Cyproterone Acetate / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D009336:Necrosis; D011471:Prostatic Neoplasms / Q000188:drug therapy; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D017373:Cyproterone Acetate
vernacular_title: Necrosi epatica acuta in paziente sottoposto a terapia con ciproterone acetato.