title: Therapy-related leukemia and myelodysplasia following oral administration of etoposide for recurrent breast cancer.
abstract: We report a high risk of therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-AML/MDS) in patients receiving oral administration of etoposide for recurrent breast cancer. We examined 119 patients with recurrent disease. Patients were initially treated with anthracyclines, cyclophosphamide, or cisplatin with or without radiation before etoposide treatment. Etoposide was used as the final drug in most cases. Twenty-four patients were treated with the oral administration of etoposide (50 or 100 mg/day for 5-7 days at 4-week intervals). Three cases of t-AML/MDS developed among those 24 patients exposed to etoposide. In contrast, the development of t-AML/MDS was not observed in the other 95 patients not treated with etoposide. Our data suggest that there is a substantial risk of secondary leukemia with oral administration of etoposide for a prolonged period as well as i.v. schedules.
authors.affiliation: Department of Clinical Hematology and Immunology, Tazuke-Kofukai Medical Research Institute, Kitano Hospital, Kita-ku, Osaka 530-0026, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yagita
authors.forename: Y
authors.initials: Y
authors.lastname: Ieki
authors.forename: R
authors.initials: R
authors.lastname: Onishi
authors.forename: C L
authors.initials: CL
authors.lastname: Huang
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: S
authors.initials: S
authors.lastname: Horiike
authors.forename: Y
authors.initials: Y
authors.lastname: Konaka
authors.forename: T
authors.initials: T
authors.lastname: Taki
authors.forename: M
authors.initials: M
authors.lastname: Miyake
mesh_terms: D000284:Administration, Oral; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy*; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced*; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D012008:Recurrence; D012307:Risk Factors
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014408:Biomarkers, Tumor; D005047:Etoposide