Lipid modifications and membrane targeting of G alpha.
G protein alpha-subunits (G alpha) undergo palmitoylation and/or myristoylation. This review will focus on new insights into the function and regulation of these fatty acid modifications of G alpha. Most importantly, I will examine lipid modifications of G alpha in the context of a two-signal model for membrane attachment, discuss recent advances in the identification of palmitoyl transferases, and highlight several controversial issues in this field.
Wedegaertner
P B
PB
Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA. P_Wedegaertner@ac.jc.tju.edu
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D008969:Molecular Sequence Data; D019814:Myristic Acid / Q000378:metabolism; D019308:Palmitic Acid / Q000378:metabolism; D015398:Signal Transduction
D008055:Lipids; D008565:Membrane Proteins; D019814:Myristic Acid; D019308:Palmitic Acid; D019204:GTP-Binding Proteins