title: Idiopathic midline destructive disease--does it exist?
abstract: There is controversy whether idiopathic mid-line destructive disease remains a valid entity, some authors considering that such cases are unrecognized malignant lymphoma or Wegener's disease. A case is presented in which numerous nasal biopsies over several years failed to show evidence of either lymphoma or Wegener's disease. Molecular genetic analysis of archival tissue did not demonstrate a monoclonal lymphoid population. It is proposed that idiopathic mid-line destructive disease remains a valid description in a small number of cases.
authors.affiliation: Department of Histopathology, Norfolk and Norwich Hospital, UK.
authors.forename: T H
authors.initials: TH
authors.lastname: Barker
authors.forename: A A
authors.initials: AA
authors.lastname: Hosni
mesh_terms: D000328:Adult; D005260:Female; D006103:Granuloma, Lethal Midline / Q000145:classification / Q000473:pathology*; D006801:Humans; D009667:Nose Deformities, Acquired / Q000473:pathology; D009626:Terminology as Topic