Adult cutaneous Langerhans cell histiocytosis.
A 24-year-old male presented with a 4 year history of a crusted erythematous papular eruption of the scalp and external auditory meati and a 12 month history of painful perianal ulceration. A diagnosis of Langerhans cell histiocytosis was made and confirmed by skin histology. Extensive investigation revealed no systemic involvement. Rapid improvement occurred after intravenous 2-chlorodeoxyadenosine but relapse of perianal lesions occurred within 5 months. Local radiotherapy to the perianal region resulted in a complete remission sustained over 12 months.
Conias
S
S
Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Strutton
G
G
Stephenson
G
G
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D017338:Cladribine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008297:Male; D011878:Radiotherapy; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis* / Q000628:therapy*
D000970:Antineoplastic Agents; D017338:Cladribine