Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives.
Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti-trypanosomal agents. The compounds were prepared in good to excellent yields in 2-3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox.
Cerecetto
H
H
Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Di Maio
R
R
Ibarruri
G
G
Seoane
G
G
Denicola
A
A
Peluffo
G
G
Quijano
C
C
Paulino
M
M
D000818:Animals; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D012664:Semicarbazones; D014344:Trypanocidal Agents