title: Prolonged remission of endometrial cancer with paclitaxel and carboplatin.
abstract: Recurrent endometrial cancer has grave prognosis. Chemotherapy and hormonal therapy are mainstays of palliative treatment. Unfortunately the frequency of complete response and duration of progression-free interval are limited. This case report describes a patient with recurrent metastatic endometrial cancer who was initially treated with radiotherapy followed by surgery. Her recurrent tumor progressed during treatment with external radiation and a progestogen. She received paclitaxel (135 mg/m2 i.v. infusion over 24 h) and carboplatin (AUC 7.5 microg x h/ml) every 4 weeks with complete remission after 8 months which has persisted for 22 months. Paclitaxel and carboplatin combination should be considered for the treatment of endometrial cancer.
authors.affiliation: Department of Clinical Investigation, University of Texas MD Anderson Cancer Center, Houston 77030-4095, USA.
authors.forename: A
authors.initials: A
authors.lastname: Vasuratna
authors.forename: A P
authors.initials: AP
authors.lastname: Kudelka
authors.forename: C L
authors.initials: CL
authors.lastname: Edwards
authors.forename: V
authors.initials: V
authors.lastname: Wootipoom
authors.forename: C F
authors.initials: CF
authors.lastname: Verschraegen
authors.forename: C
authors.initials: C
authors.lastname: Charnsangavej
authors.forename: J J
authors.initials: JJ
authors.lastname: Kavanagh
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D012008:Recurrence; D013997:Time Factors
chemical_list: D016190:Carboplatin; D017239:Paclitaxel