POLINA: detection and evaluation of single amino acid substitutions in protein superfamilies.
RESULTS
An algorithm is described for the quick identification and evaluation of amino acid substitutions in multiple protein sequence alignment. The strategy is based on the calculation of a relative conservation index for an amino acid at each position of the alignment. The algorithm is implemented in the computer program POLINA (Protein Oriented LINear Analysis) which provides a summary of analysis in a format suitable for import into a graphing program.


BACKGROUND
A copy of source code is available upon request from the authors or can be downloaded via the WWW at http://www.geocities.com/Athens/4654/POLINA.h tml.


BACKGROUND
slevin@aecom.yu.edu; bsatir@aecom.yu.edu
Levin
S
S
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. slevin@aecom.yu.edu
Satir
B H
BH
D000465:Algorithms; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D003196:Computer Graphics; D017124:Conserved Sequence; D005189:False Positive Reactions; D006454:Hemoglobins / Q000235:genetics; D006801:Humans; D017354:Point Mutation; D016415:Sequence Alignment; D012984:Software
D006454:Hemoglobins