Predictive docking of protein-protein and protein-DNA complexes.
Recent developments in algorithms to predict the docking of two proteins have considered both the initial rigid-body global search and subsequent screening and refinement. The result of two blind trials of protein docking are encouraging--for complexes that are not too large and do not undergo sizeable conformational change upon association, the algorithms are now able to suggest reasonably accurate models.
Sternberg
M J
MJ
Biomolecular Modelling Laboratory, Imperial Cancer Research Fund, London, UK.
Gabb
H A
HA
Jackson
R M
RM
D000465:Algorithms; D000818:Animals; D000906:Antibodies / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D006388:Hemagglutinins / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D046911:Macromolecular Substances; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism
D000906:Antibodies; D004791:Enzyme Inhibitors; D006388:Hemagglutinins; D046911:Macromolecular Substances; D011506:Proteins; D065093:beta-Lactamase Inhibitors; D004247:DNA; D001618:beta-Lactamases