title: [The use of clofelin for the treatment of arterial hypertension and for the anesthesia of labor].
abstract: Fourteen women in labor with pregnancy of 39.1 +/- 1.1 gestational weeks and arterial hypertension (BSP of 183.4 +/- 12.4 and BDP of 90.6 +/- 14.3 mm Hg) were given chlopheline with a rate of infusion 0.0005, 0.001 mg/kg/hr for 120 min. Decrease of arterial pressure began at minute 15.7 +/- 0.3 after starting perfusion, and the hypotensive effect lasted for 300 minutes. At minute 360, a new dose of chlopheline was needed. Against the background of arterial hypertension, a decrease of BSP, BDP and P was observed, and the central hemodynamics remained unchanged within statistically reliable range. The changes observed in the hemodynamics did not affect labor activity and the fetus. The analgesic effect of chlopheline was favorable. Perfusion of chlopheline at a rate of infusion 0.0005, 0.001 mg/kg/hr is a choice to provide a bulk of positive hypotensive and analgesic affect on the woman in labor.
authors.forename: R
authors.initials: R
authors.lastname: Radev
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage*; D000328:Adult; D000773:Anesthesia, Obstetrical; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D003000:Clonidine / Q000008:administration & dosage*; D010122:Cystinyl Aminopeptidase / Q000097:blood / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007743:Labor, Obstetric / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D011263:Pregnancy Trimester, Third; D013997:Time Factors
chemical_list: D000316:Adrenergic alpha-Agonists; D000959:Antihypertensive Agents; D010122:Cystinyl Aminopeptidase; D003000:Clonidine; D006854:Hydrocortisone
vernacular_title: Izpolzvaneto na klofelina za lechenieto na arterialnata khipertoniia i obezboliavaneto na razhdaneto.