title: Mini-haptics to improve capsular fixation of plate-haptic silicone intraocular lenses.
abstract: OBJECTIVE
  To evaluate the effects of a new mini-haptic design on the strength and stability of capsular bag fixation of plate-haptic silicone intraocular lenses (IOLs) and determine whether this design encourages the growth of regenerating lens material or fibrous tissue around the haptic biomaterial and thus improves lens fixation in the capsular bag.
  
  
  METHODS
  Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Department of Ophthalmology, Charleston, South Carolina, USA.
  
  
  METHODS
  Six rabbits had bilateral continuous curvilinear capsulorhexis, phacoemulsification, and plate-haptic silicone IOL implantation. Each rabbit had a small-hole plate IOL (Chiron C10UB) implanted in the right eye and a mini-haptic plate IOL (Chiron C40UB) in the left eye. All rabbits were killed at 2 months. The force required to extract one haptic from the capsular bag was measured with a digital force gauge. Histopathologic analysis was performed on all specimens.
  
  
  RESULTS
  The mini-haptic style IOLs required significantly more extraction force than the small-hole design (P = .011). Histopathologically, proliferating lens epithelial cells were observed growing circumferentially around the mini-haptics, causing a 360 degree synechia formation. This formation did not occur with the conventional small-hole plate IOLs used as the control.
  
  
  CONCLUSIONS
  Lens epithelial cell proliferation around the mini-haptics significantly improved capsular bag fixation of the plate-haptic silicone IOL. This should decrease the incidence of clinical decentration and dislocation.
authors.affiliation: Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston 29425-2236, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Kent
authors.forename: Q
authors.initials: Q
authors.lastname: Peng
authors.forename: R T
authors.initials: RT
authors.lastname: Isaacs
authors.forename: S B
authors.initials: SB
authors.lastname: Whiteside
authors.forename: D L
authors.initials: DL
authors.lastname: Barker
authors.forename: D J
authors.initials: DJ
authors.lastname: Apple
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D019923:Capsulorhexis; D002455:Cell Division; D004847:Epithelial Cells / Q000473:pathology; D007903:Lens Capsule, Crystalline / Q000473:pathology / Q000601:surgery*; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007910:Lenses, Intraocular; D008297:Male; D011474:Prosthesis Design; D011817:Rabbits; D012826:Silicone Elastomers; D013536:Suture Techniques
chemical_list: D012826:Silicone Elastomers