title: Successful use of extracorporeal membrane oxygenation (ECMO) during BMT for SCID.
abstract: An 8-month-old girl with SCID presented with severe bronchiolitis. She received an HLA-identical sibling BMT without conditioning or GVHD prophylaxis. She deteriorated despite mechanical ventilation but had normal cardiac, hepatic and renal function. ECMO was instituted on day +3 and subsequent improvement was seen concurrently with emergence of CD4+ cells on day +11. She was taken off ECMO on day +18 and suffered a left-sided stroke evidenced by a dense left hemiplegia. She was extubated on day +25 and weaned from supplemental oxygen on day +36 and at day +100 has recovered strength in her extremities. This is the first successful use of ECMO as a bridge to engraftment in a BMT patient.
authors.affiliation: Department of Pediatrics, The Children's Hospital of Philadelphia and the University of Pennsylvania, 19104, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Leahey
authors.forename: N J
authors.initials: NJ
authors.lastname: Bunin
authors.forename: G J
authors.initials: GJ
authors.lastname: Schears
authors.forename: C A
authors.initials: CA
authors.lastname: Smith
authors.forename: A W
authors.initials: AW
authors.lastname: Flake
authors.forename: K E
authors.initials: KE
authors.lastname: Sullivan
mesh_terms: D016026:Bone Marrow Transplantation; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016511:Severe Combined Immunodeficiency / Q000628:therapy*