Decrease in the proportion of granulated CD56+ T-cells in patients with a history of recurrent abortion.
We investigated levels of CD56+ T-cells (CD3+ CD56+ cells) in peripheral circulation, which express one of the natural killer (NK) cell markers, by flow cytometry and with monoclonal antibodies in patients with a history of recurrent abortion. We compared these values with those obtained in normal women who were not pregnant as well as in normal pregnant subjects. The percentage of CD56+ T-cells in the peripheral blood of patients with a history of recurrent abortion was less than that in the non-pregnant or pregnant women. These results suggest that CD56+ T-cells with extrathymic properties may be associated with the maintenance of normal pregnancy in humans.
Yahata
T
T
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan. ironyht@med.niigata-u.ac.jp
Kurabayashi
T
T
Honda
A
A
Takakuwa
K
K
Tanaka
K
K
Abo
T
T
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D019002:CD56 Antigen / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D016176:T-Lymphocyte Subsets; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D019002:CD56 Antigen