title: [Megestrol acetate as hormone therapy in oncology].
abstract: The structure, properties and therapeutic effect of a synthesized progestin--megestrol acetate (Megace) are discussed. It is most useful in the management of local and metastatic tumors of the breast and endometrium as well as anorexia-cachexia syndrome. It is suggested that other applications in hormone therapy and new ways of avoiding untoward side-effects (weight gain) may be found.
authors.affiliation: Prof. N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
authors.forename: L M
authors.initials: LM
authors.lastname: Berstein
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy; D006801:Humans; D008525:Medroxyprogesterone / Q000627:therapeutic use; D019290:Megestrol Acetate / Q000737:chemistry / Q000627:therapeutic use*; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D045167:Progesterone Congeners / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D045167:Progesterone Congeners; D013629:Tamoxifen; D008525:Medroxyprogesterone; D019290:Megestrol Acetate
vernacular_title: Megestrol atsetat kak sredstvo gormonoterapii v onkologii.