Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene.
Activins, members of a family of proteins that includes transforming growth factor-beta (TGF-beta), are gonadal polypeptide hormones that stimulate secretion of follicle-stimulating hormone (FSH). During large-scale sequencing analysis of a 1.2-Mb fragment of human genomic DNA on 3p22-p21.3, we found the gene encoding activin receptor type IIB (hActR-IIB). Comparison of its reported cDNA sequence with this genomic sequence showed that the hActR-IIB gene consists of 11 exons and spans about 30 kb of genomic DNA.
Ishikawa
S
S
Laboratory of Molecular Medicine, University of Tokyo, Japan.
Kai
M
M
Murata
Y
Y
Tamari
M
M
Daigo
Y
Y
Murano
T
T
Ogawa
M
M
Nakamura
Y
Y
D030301:Activin Receptors, Type II; D002874:Chromosome Mapping; D016386:Chromosome Walking; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D005091:Exons / Q000235:genetics; D005796:Genes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000235:genetics; D017978:Receptors, Growth Factor / Q000235:genetics*; D017384:Sequence Deletion
D004273:DNA, Neoplasm; D017978:Receptors, Growth Factor; D030301:Activin Receptors, Type II