title: [Transgenic mice in basic research].
abstract: What are transgenic mice and what do we learn from them? In this review, we focus on the generation of "classical" transgenic and "knock-out" mice. The establishment of transgenic and gene-targeted mice provides an unique tool to study the function(s) of a given gene in the context of a whole organism. Based on selected examples, we demonstrate the potential of this transgenic technology to understand the interactions between cells, organs and organ systems in genetically engineered mice.
authors.affiliation: Physiologisches Institut, Universität Zürich.
authors.forename: M
authors.initials: M
authors.lastname: Gassmann
authors.forename: T
authors.initials: T
authors.lastname: Hennet
authors.forename: C
authors.initials: C
authors.lastname: Bauer
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology; D000818:Animals; D002543:Cerebral Hemorrhage / Q000517:prevention & control; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D010641:Phenotype; D012107:Research Design; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
chemical_list: D014409:Tumor Necrosis Factor-alpha
vernacular_title: Transgene Mäuse in der Grundlagenforschung.