title: Diffusion heterogeneity and anisotropy in rat hippocampus.
abstract: We provide evidence for anisotropic diffusion in rat corpus callosum and hippocampus. The preferential diffusion pathway in corpus callosum is along the myelinated axon fibres; in the hippocampus diffusion is easier along the transversal axis (x) than along the sagittal (y) or vertical (z) axes. In all areas studied, i.e. in the cortex, corpus callosum and hippocampus, the mean ECS volume fraction alpha (alpha = ECS volume/total tissue volume) ranged between 0.20 and 0.22 and mean non-specific uptake k' was between 4.0 and 5.9 x 10(-3) s-1. Diffusional anisotropy in the hippocampus may be of importance for extrasynaptic transmission and in the 'cross-talk' between synapses.
authors.affiliation: Department of Neuroscience, 2nd Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Mazel
authors.forename: Z
authors.initials: Z
authors.lastname: Simonová
authors.forename: E
authors.initials: E
authors.lastname: Syková
mesh_terms: D000818:Animals; D016880:Anisotropy; D001369:Axons / Q000502:physiology; D003337:Corpus Callosum / Q000502:physiology*; D004058:Diffusion; D005110:Extracellular Space / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D007478:Iontophoresis / Q000295:instrumentation / Q000379:methods; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology; D000644:Quaternary Ammonium Compounds / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000644:Quaternary Ammonium Compounds; C027917:tetramethylammonium