Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT.
OBJECTIVE
The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies.


METHODS
[123I] beta-CIT and single photon emission computed tomography were used to assess striatal dopamine transporter levels in 28 cocaine-abusing subjects and 24 comparison subjects matched as a group for age and gender.


RESULTS
Results showed a significant (approximately 20%) elevation in striatal V3" values in acutely abstinent cocaine-abusing subjects relative to comparison subjects. An inverse correlation between dopamine transporter level and Hamilton Depression Rating Scale score was also observed.


CONCLUSIONS
These findings indicate more modest elevations in striatal dopamine transporters in cocaine-abusing subjects than noted in previous postmortem reports and suggest a possible relationship between cocaine-related depression and dopamine transporter binding.
Malison
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RT
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA. robert.malison@yale.edu
Best
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van Dyck
C H
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McCance
E F
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Wallace
E A
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Laruelle
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Baldwin
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Seibyl
J P
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Price
L H
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Kosten
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Innis
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D000328:Adult; D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology; D003042:Cocaine / Q000031:analogs & derivatives; D019970:Cocaine-Related Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D015897:Comorbidity; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism*; D003866:Depressive Disorder / Q000453:epidemiology / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism* / Q000502:physiology; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D015899:Tomography, Emission-Computed, Single-Photon
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine; D004298:Dopamine