Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain.
Recent reports suggest that oral choline supplement may alter the cerebral choline/creatine (Cho/Cr) ratio and might be used to treat neurodegenerative disorders of cholinergic transmission. Using both 1H and 31P MRS, we reexamined the Cho/Cr ratio and quantified cerebral choline and its major constituents: phosphoethanolamine (PE), phosphorylcholine (PC), glycerophosphorylethanolamine (GPE), and glycerophosphorylcholine (GPC). In the four brain locations examined, no significant increases in Cho/Cr, [Cho], or in its major constituents were found in response to an oral challenge of 50 mg/kg of choline bitartrate. Oral choline did not significantly affect human cerebral metabolism in the short term.
Tan
J
J
Huntington Medical Research Institute, Pasadena, California 91105, USA.
Bluml
S
S
Hoang
T
T
Dubowitz
D
D
Mevenkamp
G
G
Ross
B
B
D000284:Administration, Oral; D000328:Adult; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002794:Choline / Q000008:administration & dosage* / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D012016:Reference Values; D009435:Synaptic Transmission / Q000502:physiology
D003401:Creatine; D002794:Choline