title: Gestational diabetes mellitus. Unresolved issues and future research directions.
abstract: OBJECTIVE
  To summarize the controversial aspects of gestational diabetes (GDM) and introduce readers to possible relevant research questions that could be examined to provide clinicians with good-quality data on which to base decisions about this relatively common pregnancy-related issue.
  
  
  METHODS
  Ongoing review of the English literature related to GDM. Sources were not restricted to prospective, controlled trials, as these are severely limited in number.
  
  
  RESULTS
  Controversial issues include the relevance of GDM to clinically meaningful outcomes in the index pregnancy, the effectiveness of current therapy in altering these outcomes, and the resultant questionable relevance of routine screening and diagnosis of an entity with as yet uncertain significance in pregnancy.
  
  
  CONCLUSIONS
  Suggested questions to be addressed in multicentre controlled trials include randomization with respect to screening and with respect to treatment. Until such trials are completed, continuing with a standard approach to screening, diagnosis, and treatment, such as that suggested by the third international workshop on GDM, is recommended.
authors.affiliation: Department of Obstetrics and Gynecology, Royal Alexandra Hospital, University of Alberta, Calgary.
authors.forename: N
authors.initials: N
authors.lastname: Okun
authors.forename: A
authors.initials: A
authors.lastname: Verma
authors.forename: N
authors.initials: N
authors.lastname: Demianczuk
mesh_terms: D003362:Cost-Benefit Analysis; D016640:Diabetes, Gestational / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D003927:Diet, Diabetic; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011256:Pregnancy Outcome; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity