title: In vitro activity of a new ketolide antibiotic, HMR 3647, against Chlamydia pneumoniae.
abstract: The in vitro activities of HMR 3647, roxithromycin, erythromycin, and azithromycin against 19 strains of Chlamydia pneumoniae were tested. The MIC at which 90% of the isolates are inhibited and the minimum bactericidal concentration at which 90% of the isolates are killed of HMR 3647 were 0.25 microgram/ml (range, 0.015 to 2 micrograms/ml). Nine recently obtained clinical isolates from children with pneumonia were more susceptible (MICs, 0.015 to 0.0625 microgram/ml) than older strains that had been passaged more extensively.
authors.affiliation: Department of Pediatrics, SUNY Health Science Center at Brooklyn, New York 11203, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Roblin
authors.forename: M R
authors.initials: MR
authors.lastname: Hammerschlag
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D015575:Roxithromycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D015575:Roxithromycin; D004917:Erythromycin; D017963:Azithromycin; C106791:telithromycin