title: Hyperlactatemia during acute severe asthma.
abstract: OBJECTIVE
  To evaluate arterial lactate levels during treatment of acute severe asthma (ASA) and the prognostic value of arterial hyperlactatemia in ASA.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  A respiratory intensive care unit (ICU) of a university hospital.
  
  
  METHODS
  29 consecutive patients admitted to the ICU for ASA not intubated on admission and with a peak expiratory flow (PEF) < 150 l/min or an arterial carbondioxide tension (PaCO2) > 40 mm Hg. All patients received standardized treatment during the first 24 h including i.v. and nebulized salbutamol, i.v. theophylline, and dexamethasone.
  
  
  RESULTS
  Arterial lactate levels were serially measured by an enzymatic method during the first 24 h following admission. On admission, the mean arterial lactate level was 3.1 +/- 0.38 mmol/l (range 1.1-10.4); 17 patients (59%) had arterial hyperlactatemia with a lactate level > 2 mmol/l. No difference was found in lactate levels between patients with progressively worsening asthma and those with an acute onset of severe asthma. No correlation was found between arterial lactate levels on admission, on the one hand, and respiratory rate (RR), heart rate, PEF, pH, PaCO2, arterial oxygen tension, potassium, phosphorus, creatine kinase, or transaminase values on admission, on the other hand. All patients developed an important but transient increase in arterial lactate levels during treatment, with a peak at 7.72 +/- 0.46 mmol/l and a mean elevation of 4.62 +/- 0.45 mmol/l (range 0.4-12.1), from the initial admission value contrasting with a significant clinical improvement assessed by RR, PEF, and arterial blood gas parameters.
  
  
  CONCLUSIONS
  This study suggests that, in ASA, arterial hyperlactatemia is frequently present on admission to the ICU. Delayed hyperlactatemia is a constant finding during treatment of ASA. Initial or delayed hyperlactatemia seems of no prognostic value because none of the patients required mechanical ventilation. The effects of therapy for acute asthma on lactate metabolism still need to be studied.
authors.affiliation: Service de Pneumologie et Réanimation Médicale, Hôtel-Dieu de Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Rabbat
authors.forename: J P
authors.initials: JP
authors.lastname: Laaban
authors.forename: A
authors.initials: A
authors.lastname: Boussairi
authors.forename: J
authors.initials: J
authors.lastname: Rochemaure
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood* / Q000209:etiology*; D000208:Acute Disease; D000328:Adult; D001158:Arteries; D001249:Asthma / Q000150:complications* / Q000628:therapy; D001784:Blood Gas Analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D010366:Peak Expiratory Flow Rate; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D019344:Lactic Acid