Immunoallergic granulomatous interstitial nephritis following treatment with omeprazole.
A 69-year-old male who had a long history of ocular myasthenia was treated with omeprazole for 3 months. Progressive renal insufficiency was discovered fortuitously. There were no clinical or laboratory manifestations of immunoallergy. Renal biopsy revealed severe granulomatous interstitial nephritis, tubular injury and fibrosis. Histology of a liver nodule disclosed hepatic granulomatous involvement. Withdrawal of omeprazole and a short course of corticosteroids were followed by improvement but not normalization of renal function. This is the eighth report of omeprazole-induced interstitial nephritis. In the present case as in 2 others in the literature, the patients had been followed up for an autoimmune disease previously, which suggests that in patients with such a background, patients should be examined regularly for renal functional impairment during treatment with omeprazole.
Montseny
J J
JJ
Service de Néphrologie, Hôpital Intercommunal, Montreuil, France.
Meyrier
A
A
D000368:Aged; D000897:Anti-Ulcer Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D009157:Myasthenia Gravis / Q000276:immunology; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D015835:Ocular Motility Disorders / Q000276:immunology; D009853:Omeprazole / Q000009:adverse effects* / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D009853:Omeprazole