[Structure of the rat lymphoid organs after prenatal exposure to indomethacin during antigenic stimulation].
Primary immune response of thymus and mesenteric lymph nodes to prenatal action of indomethacin was studied in one month rats. Indexes of cell reactions in the experimental rat thymus were found to coincide with control during all phases although blast transformation intensity was slightly reduced. In mesenteric lymph nodes primary immune response was suppressed which was connected with lymphocyte functional insufficiency. This is manifested through less intensive intercellular cooperation in the first phase, suppression of blast transformation in B lymphocytes in the second and decrease of functional activity of the node B zones in the third ones.
Morozova
E V
EV
Department of Human Anatomy, I.I. Mechnikov State Medical Academy, St. Petersburg.
D000818:Animals; D000917:Antibody Formation; D004353:Drug Evaluation, Preclinical; D005260:Female; D007114:Immunization; D007213:Indomethacin / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D008213:Lymphocyte Activation / Q000187:drug effects; D008643:Mesentery / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure
D007213:Indomethacin
Stroenie limfoidnykh organov krys posle prenatal'nogo vozdeĭstviia indometatsina pri antigennoĭ stimuliatsii.