Elevated serum digoxin level associated with coadministered fluoxetine.
After her daughter died, depression developed in a 93-year-old woman with congestive heart failure receiving digoxin therapy. After treatment with fluoxetine hydrochloride she became anorexic and her serum digoxin level increased. A possible interaction, which has not been reported in the literature, may have occurred between fluoxetine and digoxin.
Leibovitz
A
A
Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Bilchinsky
T
T
Gil
I
I
Habot
B
B
D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000097:blood*; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000097:blood*; D004077:Digoxin / Q000097:blood*; D004347:Drug Interactions; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D006801:Humans
D000889:Anti-Arrhythmia Agents; D018687:Antidepressive Agents, Second-Generation; D002316:Cardiotonic Agents; D005473:Fluoxetine; D004077:Digoxin