title: [The effect of antibodies on the Ca2+ release from the sarcoplasmic reticulum of the papillary muscle of the rat heart].
abstract: In experiments of skinned with saponin papillary muscles (PM) of the rat's heart we studied the effects of antibodies (AB), which are specific for the sarcoplasmic reticulum's membranes (SPR). AB (1-5 mg protein/ml) have been established to enhance the amplitude of the isometric PM tension. Inhibition of the Ca2+ release from SPR and its previous release prevented the development of the exciting effect of AB. Thus, AB increase the amplitude of PM contraction due to their intracellular mobilizing action.
authors.affiliation: A. A. Bogomoletz Institute of Physiology, Nat. Acad. Sci., Kiev.
authors.forename: R I
authors.initials: RI
authors.lastname: Ianchiĭ
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000918:Antibody Specificity; D002118:Calcium / Q000378:metabolism*; D004306:Dose-Response Relationship, Immunologic; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
chemical_list: D000906:Antibodies; D002118:Calcium
vernacular_title: Vplyv antytil na vykhid Ca2+ iz sarkoplazmatychnoho retikuluma papiliarnoho m'iaza sertsia shchura.