title: Silicon granulomas and dermatomyositis-like changes associated with chronic eyelid edema after silicone breast implant.
abstract: Silicone medical products may be associated with various complications. Recent attention has focused particularly on health risks associated with silicone breast implants. The authors present the clinical and histopathological findings in a 71-year-old woman who had previously undergone breast reconstruction with a silicone gel-filled elastomer envelope-type breast implant and who developed severe chronic eyelid edema and inflammation. Extensive systemic evaluation and serologic studies were unrevealing, prompting biopsy of the eyelids. Histopathologic evaluation of the upper eyelids revealed scattered noncaseating granulomas throughout the dermis, an atrophying interface dermatitis with a sparse perivascular lymphocytic infiltrate, and focal perivascular and interstitial lymphocytic infiltrates of the muscles. Scanning electron microscopy demonstrated particles of material within the granulomas, which were revealed by electron probe x-ray microanalysis to contain silicon. The presence of silicon-containing material within areas of eyelid inflammation supports a role for silicon in the pathogenesis of this patient's condition. In the absence of other predisposing conditions, migration of silicone breast implant material must be considered.
authors.affiliation: Lions Eye Institute, Albany, New York 12208, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Meyer
authors.forename: H X
authors.initials: HX
authors.lastname: Bui
authors.forename: J A
authors.initials: JA
authors.lastname: Carlson
authors.forename: C D
authors.initials: CD
authors.lastname: Ratliff
authors.forename: M C
authors.initials: MC
authors.lastname: Guevarra
authors.forename: A D
authors.initials: AD
authors.lastname: DelRosario
authors.forename: J S
authors.initials: JS
authors.lastname: Ross
authors.forename: M
authors.initials: M
authors.lastname: Mihm
mesh_terms: D000368:Aged; D018427:Breast Implants / Q000009:adverse effects*; D002908:Chronic Disease; D003882:Dermatomyositis / Q000209:etiology* / Q000473:pathology; D004487:Edema / Q000209:etiology* / Q000473:pathology; D004577:Electron Probe Microanalysis; D005141:Eyelid Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D016462:Mammaplasty; D012826:Silicone Elastomers / Q000009:adverse effects* / Q000032:analysis
chemical_list: D012826:Silicone Elastomers