Administration of interleukin-1 at birth affects dopaminergic neurons in adult mice.
Interleukin-1 beta (IL-1 beta), a cytokine that plays a relevant role during inflammatory and immune processes, can also affect brain neurotransmitters and the activity of peripheral sympathetic nerves. Because both brain and peripheral catecholaminergic systems in mice are not fully developed at birth, we speculated that the development of these systems may be susceptible to modifications when mice are exposed to IL-1 beta early in life. Here we report that the administration to mice of a low dose of IL-1 beta during the first days of life results in a decreased dopamine content in the hypothalamus in adulthood. We also show that the dopamine content of the superior cervical sympathetic ganglia was reduced in adult mice that were treated with IL-1 beta at birth. No changes in noradrenaline content nor in its metabolite MHPG were detected in the brain and peripheral sympathetic ganglia of these animals. This indicates that central and probably also peripheral dopaminergic neurons are preferentially affected by IL-1 beta treatment at birth. Collectively, these results indicate that an increased production of IL-1 beta during infectious or inflammatory processes in the perinatal period may induce long-lasting, probably permanent, alterations in central and peripheral neurotransmitter systems.
Kabiersch
A
A
Division of Immunophysiology, Medical Faculty, Philipps-University, Marburg, Germany.
Furukawa
H
H
del Rey
A
A
Besedovsky
H O
HO
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D017783:Superior Cervical Ganglion / Q000166:cytology / Q000378:metabolism
D002395:Catecholamines; D007375:Interleukin-1; D004247:DNA; D004298:Dopamine