title: Effect of the introduction of total mesorectal excision for the treatment of rectal cancer.
abstract: BACKGROUND
  Total mesorectal excision (TME) has been reported to reduce local recurrence and improve survival rates in patients with rectal carcinoma. This paper reports the problems that have arisen with the introduction of this new surgical technique.
  
  
  METHODS
  This was a prospective study of two consecutive groups of patients: one who underwent TME (n = 76) and one who did not (non-TME, n = 76).
  
  
  RESULTS
  Postoperative mortality rate in the non-TME and TME group was 5 and 7 per cent respectively, and the rate of anastomotic failure was 8 and 16 per cent respectively. Anastomotic leaks in TME patients were located in the mid and lower rectum. TME patients with anastomotic failure had lower anastomoses and a longer duration of operation than non-TME patients. Intraoperative problems were encountered in 71 per cent of the failures. All TME patients who had a leak required reoperation compared with 25 per cent of non-TME patients. TME patients without postoperative complications stayed significantly longer in hospital than non-TME patients.
  
  
  CONCLUSIONS
  Anastomotic dehiscence increased after introduction of the TME technique but this improved with experience.
authors.affiliation: Surgical Department, Ullevaal Hospital, University of Oslo, Norway.
authors.forename: E
authors.initials: E
authors.lastname: Carlsen
authors.forename: E
authors.initials: E
authors.lastname: Schlichting
authors.forename: I
authors.initials: I
authors.lastname: Guldvog
authors.forename: E
authors.initials: E
authors.lastname: Johnson
authors.forename: R J
authors.initials: RJ
authors.lastname: Heald
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D006801:Humans; D007902:Length of Stay; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011183:Postoperative Complications; D011446:Prospective Studies; D011475:Prosthesis Failure; D012004:Rectal Neoplasms / Q000601:surgery*; D012422:Rupture, Spontaneous / Q000209:etiology; D013529:Surgical Wound Dehiscence / Q000209:etiology; D013997:Time Factors