title: New drugs and changing disease paradigms.
authors.affiliation: Isis Pharmaceuticals, Carlsbad, CA, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Crooke
mesh_terms: D001709:Biotechnology; D015195:Drug Design; D004345:Drug Industry / Q000191:economics; D004358:Drug Therapy / Q000639:trends*; D006801:Humans; D007449:Investments