title: Lyme disease complicated by the Jarisch-Herxheimer reaction.
abstract: A 31-year-old woman diagnosed with Lyme disease was treated with amoxicillin. One hour after the first antibiotic dose, the patient became acutely ill. She developed hypertension, fever, and rigors. Shortly afterward, she became hypotensive and required fluid resuscitation. This systemic illness, the Jarisch-Herxheimer reaction, was first noted in association with antibiotic therapy for neurosyphilis. Thus, the institution of antibiotic therapy may be complicated by the Jarisch-Herxheimer reaction.
authors.affiliation: The Department of Emergency Medicine, Hospital of Saint Raphael, New Haven, Connecticut 06511, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Maloy
authors.forename: R D
authors.initials: RD
authors.lastname: Black
authors.forename: R J
authors.initials: RJ
authors.lastname: Segurola
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008193:Lyme Disease / Q000150:complications* / Q000188:drug therapy*; D012772:Shock, Septic / Q000209:etiology* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin