title: From histamine H2 receptor regulation to reclassification of H2 antagonists; inverse agonism as the basis for H2 receptor upregulation.
authors.affiliation: Leiden/Amsterdam Center for Drug Research, Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Smit
authors.forename: H
authors.initials: H
authors.lastname: Timmerman
authors.forename: A E
authors.initials: AE
authors.lastname: Alewijnse
authors.forename: R
authors.initials: R
authors.lastname: Leurs
mesh_terms: D000818:Animals; D016466:CHO Cells; D002927:Cimetidine / Q000494:pharmacology*; D006224:Cricetinae; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D051381:Rats; D011970:Receptors, Histamine H2 / Q000235:genetics / Q000378:metabolism*
chemical_list: D006635:Histamine H2 Antagonists; D011970:Receptors, Histamine H2; D002927:Cimetidine