Marked left ventricular hypertrophy in children on tacrolimus (FK506) after orthotopic liver transplantation.
Although the cardiac effects of tacrolimus (FK506) have not been well documented, clinical cases of children on FK506 who developed hypertrophic obstructive cardiomyopathy have been reported. We report 2 cases of marked concentric hypertrophy of the left ventricular myocardium found at autospy in children on FK506.
Chang
R K
RK
Department of Pediatrics, UCLA Medical Center, Los Angeles, California 90024, USA.
Alzona
M
M
Alejos
J
J
Jue
K
K
McDiarmid
S V
SV
D002648:Child; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000139:chemically induced* / Q000473:pathology*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007231:Infant, Newborn; D016031:Liver Transplantation; D008297:Male; D016559:Tacrolimus / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D016559:Tacrolimus