title: Mixed connective tissue disease with severe pulmonary hypertension and extensive subcutaneous calcification.
abstract: The results of the autopsy of a 38-year-old female with mixed connective tissue disease who had suffered from painful subcutaneous calcification in her buttocks and extremities for 14 years and died from rapidly progressive pulmonary hypertension are reported. On autopsy, her heart and lungs revealed changes of severe pulmonary hypertension with intimal thickening and plexiform lesions in the small pulmonary arteries which had resulted in the collapse of both lungs and caused marked dilatation and hypertrophy of the right ventricle of the heart. Microscopic examinations of the subcutaneous calcified tissues indicated that the calcification may have been caused by repeated panniculitis.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical College, Hikarigaoka.
authors.forename: O
authors.initials: O
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Nishimaki
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: H
authors.initials: H
authors.lastname: Ohira
authors.forename: A
authors.initials: A
authors.lastname: Irisawa
authors.forename: S
authors.initials: S
authors.lastname: Kaise
authors.forename: R
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006328:Cardiac Catheterization; D004452:Echocardiography; D004562:Electrocardiography; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000473:pathology; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000473:pathology; D011651:Pulmonary Artery / Q000473:pathology; D011859:Radiography; D012871:Skin Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology