Evidence for immune system involvement in reflex sympathetic dystrophy.
Skin biopsies from patients with reflex sympathetic dystrophy were immunostained using a variety of antisera. An incidental finding with S100 staining was the presence of numerous Langerhans cells in the epidermis. All patients had significant pain at the time of biopsy, and all had symptoms refractory to treatment. The potential implications of this finding are discussed.
Calder
J S
JS
Blond-McIndoe Research Centre, Queen Victoria Hospital, East Grinstead, UK.
Holten
I
I
McAllister
R M
RM
D000328:Adult; D000368:Aged; D001706:Biopsy; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002422:Causalgia / Q000276:immunology / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006225:Hand / Q000601:surgery; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D009412:Nerve Fibers / Q000276:immunology / Q000473:pathology; D009416:Nerve Regeneration / Q000276:immunology; D011183:Postoperative Complications / Q000276:immunology / Q000473:pathology; D012019:Reflex Sympathetic Dystrophy / Q000276:immunology* / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism*; D012867:Skin / Q000276:immunology / Q000294:innervation / Q000473:pathology; D013373:Substance P / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
D009418:S100 Proteins; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D014446:Tyrosine 3-Monooxygenase; D015740:Calcitonin Gene-Related Peptide