Chiral separations by capillary electrophoresis in process chemistry.
The utility of capillary electrophoresis in process chemistry to evaluate/optimize a synthetic organic process like classical resolution is demonstrated. Simultaneous monitoring of degradation products and optical purity is shown.
Silverman
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DuPont Merck Pharmaceutical Co., Chemical Process R&D, Deepwater, NJ, USA.
D000577:Amides / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods* / Q000592:standards; D007769:Lactams / Q000032:analysis*; D008968:Molecular Conformation; D010879:Piperazines / Q000032:analysis*
D000577:Amides; D007769:Lactams; D010879:Piperazines