title: Medication take-home doses and contingency management.
abstract: Two studies examined contingent take-home medication doses during treatment of opiate or cocaine dependence. In the first study, methadone maintenance patients were randomly assigned to one of two 8-week baseline take-home (TH) conditions differing in frequency of clinic visits per week. This was followed by a 12-week contingency management (CM) procedure in which frequent THs resulted from drug-free urines. Participants receiving more frequent THs during baseline had lower illicit drug use during the first 6 weeks of CM. In the second study, fluoxetine (0-, 20-, 40-mg) TH doses were similarly contingent in treatment of cocaine dependence. The 40-mg group used less cocaine during contingency than did other groups. The combination of fluoxetine and environmental contingencies may produce benefit where neither alone is sufficient.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston 77030, USA. jschmitz@msi66.msi.uth.tmc.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Schmitz
authors.forename: H M
authors.initials: HM
authors.lastname: Rhoades
authors.forename: R
authors.initials: R
authors.lastname: Elk
authors.forename: D
authors.initials: D
authors.lastname: Creson
authors.forename: I
authors.initials: I
authors.lastname: Hussein
authors.forename: J
authors.initials: J
authors.lastname: Grabowski
mesh_terms: D000328:Adult; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage*; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000188:drug therapy* / Q000523:psychology
chemical_list: D005473:Fluoxetine; D008691:Methadone