title: [Hypertonic-hyperoncotic solutions: possibilities and limits].
abstract: Hypertonic-hyperoncotic solutions are a supplementary possibility in the acute treatment of hypovolemia. The main mechanism of action of this solution is, induced by the tonicity of the infusion (approximately 2400 mOsm/l), the transcapillary fluid shift from the intracellular and interstitial to the intravascular compartment. Additionally the fluidity of blood is improved (due to an increase in the diameter of the capillaries), the adherence of leucocytes to the endothelial wall is reduced, and the arteriolar vasomotion is restarted. Due to the available prehospital and clinical results it can be concluded, that hypertonic-hyperoncotic solutions offer advantages compared to conventional fluid therapy regimes: rapid stabilization of hemodynamics, reduction of posttraumatic volume deficiency, of posttraumatic edema and of posttraumatic complications and an improvement of the outcome of the patients. If the therapeutic recommendations are followed, such as a dose of 4 ml/kg body weight, infusion time of about 3-5 minutes and after the end of the infusion application of colloids or crystalloids in an amount as needed, no side effects will occur. Only immediately after the end of infusion sodium, chloride and osmolarity will slightly increase, however these parameters will normalize within the first posttraumatic day. Hypertonic-hyperoncotic solutions are trigger-solutions, as with the infusion of these types of solution it is possible to restore hemodynamics adequately and to prevent shock-induced complications.
authors.affiliation: Universitäts-Klinik für Anästhesiologie und Intensivmedizin, Karl-Franzens-Universität, Graz.
authors.forename: W
authors.initials: W
authors.lastname: Kröll
authors.forename: S E
authors.initials: SE
authors.lastname: Gassmayr
authors.forename: S
authors.initials: S
authors.lastname: Izmail
authors.forename: W F
authors.initials: WF
authors.lastname: List
mesh_terms: D001810:Blood Volume / Q000187:drug effects; D002200:Capillary Resistance / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006982:Hypertonic Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D012769:Shock / Q000209:etiology / Q000628:therapy*; D012774:Shock, Traumatic / Q000209:etiology / Q000628:therapy; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D006982:Hypertonic Solutions
vernacular_title: Hypertone-hyperonkotische Lösungen: Möglichkeiten und Grenzen.