Serous detachment of the ciliary body in Harada disease.
OBJECTIVE
To evaluate the involvement of the anterior ocular segment in Harada disease.


METHODS
In a prospective study, ultrasound biomicroscopy was performed in 18 consecutive eyes of nine patients with Harada disease in its acute phase before and after onset of systemic corticosteroid therapy. Examination was repeated every 3 days until the resolution of serous retinal detachment.


RESULTS
Serous detachment of the ciliary body was present in 11 (61%) of 18 eyes before treatment. The circumference of the ciliary body was detached in 10 of the 11 eyes. The height of ciliary detachment ranged from 20% to 250% of the scleral thickness. Ciliary detachment was more prominent in eyes with more extensive retinal detachment. There was no relation between the frequency of ciliary detachment and the severity of iritis. On day 3 of treatment, ciliary detachment had disappeared in seven eyes. In the other four eyes, it diminished in height to less than 10% of scleral thickness. Retinal detachment disappeared on days 6 through 17 (mean, day 11) of treatment. Two eyes of one patient showed very shallow anterior chambers. These eyes showed high ciliary detachment at 250% of scleral thickness. In another patient, both eyes developed -5.0 diopters of transient myopia.


CONCLUSIONS
Ciliary detachment was a frequent finding in the acute stage of Harada disease. Its resolution was more prompt than that of serous retinal detachment after treatment. Ciliary detachment may be related to the development of a shallow anterior chamber.
Maruyama
Y
Y
Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan. ymaruyam@news.sb.gunma-u.ac.jp
Kimura
Y
Y
Kishi
S
S
Shimizu
K
K
D000208:Acute Disease; D000328:Adult; D000867:Anterior Chamber / Q000473:pathology; D002924:Ciliary Body / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007500:Iritis / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012163:Retinal Detachment / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D014463:Ultrasonography; D014603:Uveal Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications* / Q000188:drug therapy
D005938:Glucocorticoids; D003907:Dexamethasone