title: [Acute therapy of episodic and chronic cluster headache with sumatriptan s.c. Results of a one-year long-term study].
abstract: The aim of the open prospective study was to investigate the efficacy, safety and tolerability of subcutaneous sumatriptan in the acute treatment of cluster headache. Self-treatment with 6 mg sumatriptan subcutaneously was monitored over a period up to 1 year. Headache parameters were documented by the patients with a headache diary. A total of 2031 attacks in 52 patients were investigated. Treatment with sumatriptan was effective in 88% of the attacks and 57% of the patients were pain-free within 15 min after injection; 42% of the patients became painfree within 15 min after at least 90% of their attacks. During long-time treatment the efficacy remained unchanged. Of the patients 10% withdrew from the study due to lack of efficacy or adverse events. In total, 62% of the patients reported adverse events, which were serious in 3.8% of the cases. Subcutaneous self-treatment of cluster headache is both highly effective and well tolerated.
authors.affiliation: Neurologisch-verhaltensmedizinische Schmerzklinik Kiel in Kooperation mit dem Klinikum, Christian-Albrechts-Universität Kiel.
authors.forename: H
authors.initials: H
authors.lastname: Göbel
authors.forename: V
authors.initials: V
authors.lastname: Lindner
authors.forename: V
authors.initials: V
authors.lastname: Pfaffenrath
authors.forename: M
authors.initials: M
authors.lastname: Ribbat
authors.forename: A
authors.initials: A
authors.lastname: Heinze
authors.forename: H
authors.initials: H
authors.lastname: Stolze
mesh_terms: D000208:Acute Disease; D000328:Adult; D003027:Cluster Headache / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018170:Sumatriptan / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D018170:Sumatriptan
vernacular_title: Akuttherapie des episodischen und chronischen Clusterkopfschmerzes mit Sumatriptan s.c. Ergebnisse einer einjährigen Langzeitstudie.