title: [Treatment of accidental extravasation of antitumor agents with dimethylsulfoxide and alpha-tocopherol].
abstract: BACKGROUND
  The aim of this study was to test topical applications of dimethylsulfoxide and alpha-tocopherol for the prevention of ulcerations after antimitotic extravasation.
  
  
  METHODS
  An open prospective study was conducted in 10 patients in 4 different chemotherapy wards who had experienced infusion accidents leading to phlebitis (4 cases) or cellulitis (8 cases) including 2 at implant sites. Topical application of the dimethylsulfoxide alpha-tocopherol combination was initiated within the first hours and continued for 3 to 15 days. One patient was given dimethylsulfoxide alone.
  
  
  RESULTS
  Necrosis was never observed. The implant sites were preserved and remained functional.
  
  
  CONCLUSIONS
  The absence of secondary ulcerations and the preservation of the implant sites are clear advantages of this topical combination which should be used as first line treatment. Favorable results have been reported in the literature while other techniques used depend on the antimitotic agent and give variable results.
authors.affiliation: Unité d'Hématologie Clinique CHU Dupuytren, Limoges.
authors.forename: J M
authors.initials: JM
authors.lastname: Bonnetblanc
authors.forename: D
authors.initials: D
authors.lastname: Bordessoule
authors.forename: J
authors.initials: J
authors.lastname: Fayol
authors.forename: J M
authors.initials: JM
authors.lastname: Amici
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002481:Cellulitis / Q000139:chemically induced; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010689:Phlebitis / Q000139:chemically induced; D011446:Prospective Studies; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D014810:Vitamin E; D004121:Dimethyl Sulfoxide
vernacular_title: Traitement des accidents de perfusion d'antimitotiques par dimethylsulfoxyde et alpha-tocopherol.