Functional interactions among members of the Myc superfamily and potential relevance to cutaneous growth and development.
Myc family oncoproteins function as sequence-specific transcription factors that are believed to regulate the expression of genes governing cellular growth, differentiation, and programmed cell death. Activities of Myc are countered by those of Mad and Mxi1, two related members of the Myc superfamily. Mad and Mxi1 compete with Myc for common elements and interact with putative transcriptional repressors. While the precise role of the Myc superfamily in cutaneous biology remains to be determined, findings from a number of organ systems suggest that the regulated expression and function of its members are intimately correlated with proper development and physiology. Reviewed here are current data on Myc superfamily function with references where relevant to cutaneous processes with the ultimate goal of providing a framework upon which these proteins can be exploited in gene therapeutic approaches for diseases of the skin, including neoplasia.
Chin
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Department of Microbiology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Liégeois
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N
DePinho
R A
RA
Schreiber-Agus
N
N
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D015316:Genetic Therapy; D006655:Histone Deacetylases; D006801:Humans; D009369:Neoplasms / Q000209:etiology; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D012867:Skin / Q000254:growth & development*; D012871:Skin Diseases / Q000628:therapy; D014157:Transcription Factors / Q000502:physiology
D016271:Proto-Oncogene Proteins c-myc; D012097:Repressor Proteins; C071731:SIN3 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D006655:Histone Deacetylases