title: Lupeol is the cytotoxic principle in the leaf extract of Dendropanax cf. querceti.
abstract: The crude ethanol extract from the leaves of Dendropanax cf. querceti (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, and H-4IIE tumor cell lines. The active component has been isolated by activity-directed separation and identified by 1H- and 13C-NMR spectroscopy as the triterpene lupeol. The mechanism of cytotoxic activity of lupeol has been determined to be inhibition of topoisomerase II.
authors.forename: D M
authors.initials: DM
authors.lastname: Moriarity
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.forename: C A
authors.initials: CA
authors.lastname: Yancey
authors.forename: P
authors.initials: P
authors.lastname: Zhang
authors.forename: W N
authors.initials: WN
authors.lastname: Setzer
authors.forename: R O
authors.initials: RO
authors.lastname: Lawton
authors.forename: R B
authors.initials: RB
authors.lastname: Bates
authors.forename: S
authors.initials: S
authors.lastname: Caldera
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000094042:Lupanes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes