title: Occupational protein contact dermatitis caused by meat and fish.
abstract: BACKGROUND
  Protein contact dermatitis is a form of contact dermatitis possibly triggered by proteinaceous allergens.
  
  
  METHODS
  We report two patients with a history of erythematous and urticarial skin reactions followed by transformation into prolonged papular symptoms upon contact with proteinaceous material.
  
  
  RESULTS
  The symptoms reported by the patients were reproducible by skin testing with meat (cow) and fish (salmon). Both patients experienced extracutaneous manifestations after ingestion of meat and fish, as proven by oral challenge. Specific immunoglobulin E (IgE) antibodies were detected in the patients' blood.
  
  
  CONCLUSIONS
  Both cases meet all major criteria of protein contact dermatitis, suggesting IgE-mediated immediate-type hypersensitivity with late-phase cutaneous reactions.
authors.affiliation: Department of Dermatology, University of Frankfurt, Germany.
authors.forename: W H
authors.initials: WH
authors.lastname: Boehncke
authors.forename: H
authors.initials: H
authors.lastname: Pillekamp
authors.forename: S
authors.initials: S
authors.lastname: Gass
authors.forename: H
authors.initials: H
authors.lastname: Gall
mesh_terms: D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000276:immunology; D004044:Dietary Proteins / Q000009:adverse effects*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008460:Meat / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D012882:Skin Tests
chemical_list: D004044:Dietary Proteins; D007073:Immunoglobulin E