title: Successful management of adult respiratory distress syndrome (ARDS) after high-dose chemotherapy and peripheral blood progenitor cell rescue by non-invasive ventilatory support.
abstract: A 34-year-old man suffering from Hodgkin's disease underwent high-dose chemotherapy (CBV) followed by transplantation of autologous peripheral blood stem cells. On day +6 after peripheral blood stem cell transplant (PBSCT) bacterial pneumonia developed. Along with rapid engraftment during stimulation with G-CSF adult respiratory distress syndrome (ARDS) developed within 4 days. High-flow CPAP (continuous positive airway pressure) ventilation via a sealed face-mask was initiated. The patient tolerated the sealed face-mask very well, and CPAP was continuously administered for 4 days, thus avoiding intubation. High-flow CPAP may offer a therapeutic alternative in selected patients with respiratory compromise after PBSCT.
authors.affiliation: Department of Internal Medicine I, University of Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Rabitsch
authors.forename: T
authors.initials: T
authors.lastname: Staudinger
authors.forename: S A
authors.initials: SA
authors.lastname: Brugger
authors.forename: E
authors.initials: E
authors.lastname: Reiter
authors.forename: F
authors.initials: F
authors.lastname: Keil
authors.forename: C
authors.initials: C
authors.lastname: Herold
authors.forename: K
authors.initials: K
authors.lastname: Lechner
authors.forename: H T
authors.initials: HT
authors.lastname: Greinix
authors.forename: P
authors.initials: P
authors.lastname: Kalhs
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D008297:Male; D011175:Positive-Pressure Respiration; D012128:Respiratory Distress Syndrome / Q000628:therapy*