title: [A molecular variant of angiotensinogen gene is associated with myocardial infarction in Chinese].
abstract: OBJECTIVE
  A molecular variant of the angiotensinogen(AGT) gene with threonine instead of methionine at position 235(i.e.,with M235T polymor- phism) has been shown to be associated with essential hypertension, preeclampsia, coronary atherosclerosis, coronary heart disease(CHD), myocardial infarction(MI) in Caucasians and in Japanese. The purpose of the present study was to assess whether the M235T polymorphism was associated with MI in a Chinese population.
  
  
  METHODS
  M235T polymorphism in exon 2 of AGT gene was determined by polymerase chain reaction(PCR) and restriction endonuclease analysis in a study of 57 patients with MI and 76 non-CHD individuals as control.
  
  
  RESULTS
  The frequencies of T235 allele(0.82) and 235TT genotype (0.70) in the MI group were higher than those in the control subjects(0.63 and 0.42 respectively, P=0.013 and P<0.025). AGT gene 235TT genotype was at significantly increased risk of MI(odds ratio 3.65, P=0.016) in analysis adjusted for several main CHD risk factors.
  
  
  CONCLUSIONS
  There is a significant association between AGT gene 235TT genotype and MI, this genotype might be an independent risk for MI in Chinese population.
authors.affiliation: Department of Cardiology, Huashan Hospital, Shanghai Medical University, Shanghai, 200040 P.R.China.
authors.forename: D
authors.initials: D
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Fan
authors.forename: H
authors.initials: H
authors.lastname: Shi
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Gu
mesh_terms: D000368:Aged; D000808:Angiotensinogen / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D000808:Angiotensinogen