[Changes in the total calcium content and in the activity of alkaline phosphatase and gamma-glutamyltransferase in the blood serum of rats with Mönckeberg's experimental arteriosclerosis].
Experiments on rats (single-action, six-days' hyperepinephrinemia and monoiodacetatic acid intoxication) were performed to study the calcium concentration, alkaline phosphatase and gamma-glutamyltransferase activities in serum at Monckeberg's medial calcific sclerosis modelment. It is established reduction serum level of calcium in an hour past single-acting hyperepinephrinemia, increase it's level after six-days'-monoiodacetatic intoxication, increase of "serum alkaline phosphatase activity/gamma-glutamyltransferase activity" (as indirect evidences the bone isozyme of alkaline phosphatase and parathyroid hormone activity increase) after six-days' hyperepinephrinemia and monoiodacetatic acid intoxication. Probably, these changes in serum calcium metabolism and system it's regulation may play pathogenetic role in early period Mönckeberg's arteriosclerosogenesis.
Holdobina
O V
OV
Department of Pathophysiology, O. O. Bogomolets National Medical University, Kiev.
D000208:Acute Disease; D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D001161:Arteriosclerosis / Q000097:blood* / Q000139:chemically induced; D002114:Calcinosis / Q000097:blood / Q000139:chemically induced; D002118:Calcium / Q000097:blood*; D004195:Disease Models, Animal; D004837:Epinephrine; D007461:Iodoacetates; D019807:Iodoacetic Acid; D051381:Rats; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood*
D007461:Iodoacetates; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D002118:Calcium; D019807:Iodoacetic Acid; D004837:Epinephrine
Zminy vmistu zahal'noho kal'tsiiu, aktyvnosti luzhnoï fosfatazy i hamma-hlutamiltransferazy v syrovati krovi shchuriv pry eksperimental'nomu arteriosklerozi Menkeberha.