title: Altered bleeding time associated with ibuprofen and zidovudine use.
abstract: The purpose of this article is to describe a patient who was HIV-positive, had a massive venous ulcer, and developed a prolonged bleeding time with marked blood loss from the ulcer. The patient underwent a workup to rule out possible causes for this prolonged bleeding time; all studies were negative. A review of his history identified that he was self-medicating with ibuprofen while taking zidovudine. A potentiated effect of these two medications on the bleeding time has been reported in the literature. This case illustrates the importance of revisiting a patient's history while working up an acute problem as well as clinically monitoring for blood loss if a person takes ibuprofen and zidovudine.
authors.affiliation: Wayne State University, Detroit, Mich., USA.
authors.forename: B
authors.initials: B
authors.lastname: Pieper
authors.forename: H C
authors.initials: HC
authors.lastname: Smitherman
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001778:Blood Coagulation Disorders / Q000139:chemically induced* / Q000451:nursing; D015658:HIV Infections / Q000150:complications; D006556:Heroin Dependence / Q000150:complications; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D008297:Male; D014647:Varicose Ulcer / Q000150:complications; D015215:Zidovudine / Q000009:adverse effects*
chemical_list: D019380:Anti-HIV Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015215:Zidovudine; D007052:Ibuprofen