title: Iohexol: effects on uptake of radioactive iodine in the thyroid and on thyroid function.
abstract: OBJECTIVE
  The authors attempted to determine whether the use of nonionic contrast media causes uptake of iodine by the thyroid to be blocked and whether use of these agents could cause iodine-induced hyperthyroidism.
  
  
  METHODS
  Twenty-eight persons, including 22 with thyroid disease, were included in the study. Subjects underwent computed tomography (CT) of the thyroid after injection of 100 mL of iohexol. Thyroid function variables were measured before CT scanning and 1 week and 1 month later. In 16 subjects, uptake of iodine-131 by the thyroid was measured before and 1 week after CT.
  
  
  RESULTS
  I-131 uptake was reduced to 53.4% at 1 week after the injection of iohexol but became normal within a few weeks (followed up in one patient). An accelerated escape of I-131 from the thyroid was seen during the 1st days after the iohexol administration. Eight of 22 patients with an underlying thyroid disease had a temporary change in thyroid function. In four patients, the serum thyrotropin level was increased 1 week after the iohexol administration. In four other patients, temporary hyperthyroidism developed during the following months.
  
  
  CONCLUSIONS
  Iohexol can be used in patients with an underlying thyroid disease, but close monitoring in the following months is necessary.
authors.affiliation: Department of Endocrinology, Herlev Hospital, University of Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Nygaard
authors.forename: T
authors.initials: T
authors.lastname: Nygaard
authors.forename: L I
authors.initials: LI
authors.lastname: Jensen
authors.forename: M
authors.initials: M
authors.lastname: Court-Payen
authors.forename: P
authors.initials: P
authors.lastname: Søe-Jensen
authors.forename: K G
authors.initials: KG
authors.lastname: Nielsen
authors.forename: M
authors.initials: M
authors.lastname: Fugl
authors.forename: J M
authors.initials: JM
authors.lastname: Hansen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000139:chemically induced / Q000000981:diagnostic imaging; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D007472:Iohexol / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012307:Risk Factors; D013959:Thyroid Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007457:Iodine Radioisotopes; D007472:Iohexol; D013972:Thyrotropin