[The role of polypeptide growth factors and hormones in the formation of neuromediator status of a sympathoadrenal cell line].
Formation of the mixed pattern of neurotransmitter synthesis at intermediate stage of neuron functional differentiation involving interaction of nerve and epidermal growth factors (NGF and EGF) and also thyroxine was analysed histochemically. Analysis of change dynamics of acetyl cholinesterase catecholamine ratio influenced by NGF demonstrated its dependence on the cell type. Thyroxine potentiates NGF effect while EGF stimulates NGF-induced ACE increase only during the initial period.
Kaliunov
V N
VN
Laboratory of Regulatory Protein and Peptides, Byelorussian Academy of Sciences, Minsk.
Buravskiĭ
V A
VA
Gronskaia
R I
RI
Polukoshko
E F
EF
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002460:Cell Line; D019439:Chromaffin Cells / Q000502:physiology*; D004815:Epidermal Growth Factor / Q000502:physiology*; D006651:Histocytochemistry; D009414:Nerve Growth Factors / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D016716:PC12 Cells; D051381:Rats; D013564:Sympathetic Nervous System / Q000166:cytology / Q000502:physiology*; D013974:Thyroxine / Q000502:physiology*
D009414:Nerve Growth Factors; D018377:Neurotransmitter Agents; D004815:Epidermal Growth Factor; D000110:Acetylcholinesterase; D013974:Thyroxine
Rol' polipeptidnykh faktorov rosta i gormonov v stanovlenii neĭromediatornogo statusa kletok simpatiko-adrenalovoĭ linii.