Thrombocytopenic purpura as adverse reaction to recombinant hepatitis B vaccine.
Three cases of immune thrombocytopenic purpura after the first dose of recombinant hepatitis B vaccine occurred in infants under 6 months of age. Other possible causes of this condition were excluded. Antiplatelet antibodies were present. A defect in platelet production was excluded in two children. Corticosteroid treatment was effective. Subsequent administration of other vaccines (against polio, diphtheria, and tetanus) did not cause relapse of thrombocytopenia.
Ronchi
F
F
Divisione Pediatrica-Ospedale Civile di Cattolica (RN), Cattolica (RN), Italy.
Cecchi
P
P
Falcioni
F
F
Marsciani
A
A
Minak
G
G
Muratori
G
G
Tazzari
P L
PL
Beverini
S
S
D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology* / Q000276:immunology; D014614:Vaccines, Synthetic / Q000009:adverse effects*
D001323:Autoantibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic