Consensus workshop on the toxic effects of long-term PUVA therapy.
The possibility that there is an increased risk of melanoma in patients with psoriasis treated with psoralen-UV-A (PUVA) therapy has raised concern on the part of physicians and patients about the long-term safety of this treatment. In response to this concern, the National Psoriasis Foundation sponsored a workshop at which invited participants with expertise in PUVA therapy, psoriasis treatment, melanoma and nonmelanoma skin cancer, and epidemiological and clinical trials were asked to develop a consensus on the following 3 issues: the risk of long-term adverse effects of PUVA therapy with emphasis on nonmelanoma and melanoma skin cancer; the guidelines for physicians and patients for selection and use of PUVA therapy with consideration of the risk-benefit ratio of this treatment compared with the risk-benefit ratios of alternative treatments; and the directions for further evaluation of the long-term effects Of PUVA therapy.
Morison
W L
WL
Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.
Baughman
R D
RD
Day
R M
RM
Forbes
P D
PD
Hoenigsmann
H
H
Krueger
G G
GG
Lebwohl
M
M
Lew
R
R
Naldi
L
L
Parrish
J A
JA
Piepkorn
M
M
Stern
R S
RS
Weinstein
G D
GD
Whitmore
S E
SE
D006801:Humans; D008545:Melanoma / Q000139:chemically induced*; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy; D012306:Risk; D012878:Skin Neoplasms / Q000139:chemically induced*; D013997:Time Factors