The genetic basis for variation in antibody response to vaccines.
Following a brief review of important concepts of vaccine response and vaccine immunology, recent reports on genetic determinants of vaccine response are reviewed. Recent data demonstrating significant associations with particular human leukocyte antigen genes and responsiveness to measles and hepatitis B vaccines are discussed, along with the influence of Km and Gm allotype genes on pneumococcal polysaccharide vaccines. These recent findings have important considerations for research, vaccine development, and clinical practice.
Poland
G A
GA
Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Jacobson
R M
RM
D000917:Antibody Formation; D000940:Antigenic Variation; D001428:Bacterial Vaccines / Q000276:immunology; D005805:Genes, MHC Class I; D017325:Hepatitis B Vaccines / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000276:immunology; D007129:Immunoglobulin Gm Allotypes / Q000276:immunology; D008458:Measles Vaccine / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology; D014612:Vaccines / Q000276:immunology*
D001428:Bacterial Vaccines; D017325:Hepatitis B Vaccines; D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes; D008458:Measles Vaccine; D014612:Vaccines