Vascular targeted radioimmunotherapy with 213Bi--an alpha-particle emitter.
To destroy both tumor blood vessels and adjacent tumor cells, an alpha-particle emitter, 213Bi, has been targeted with a monoclonal antibody (MAb) to vessels that feed lung tumors in mice. Animals, bearing approximately 100 EMT-6 carcinomas each of 50-400 cells in size in the lung, that were treated with 120 muCi of 213Bi-MAb 201B were all cured of their disease. Animals treated when tumors were larger (10(3)-10(4) cells) had extended life spans, but a small number of residual tumors eventually killed the animals. Significant extension of life span was also induced with another tumor model-rat tracheal carcinoma growing in the lungs of SCID mice that were then treated with 136 muCi 213Bi-MAb 201B. These studies indicate that attack of both blood vessels and tumor cells simultaneously is an effective mode of cancer treatment.
Kennel
S J
SJ
Life Sciences Division, Oak Ridge National Laboratory, TN 37831-8080, USA. kennelsj@ornl.gov
Mirzadeh
S
S
D000512:Alpha Particles; D000818:Animals; D000911:Antibodies, Monoclonal; D001729:Bismuth / Q000627:therapeutic use*; D005260:Female; D008175:Lung Neoplasms / Q000098:blood supply / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D016499:Radioimmunotherapy / Q000379:methods*; D011868:Radioisotopes / Q000627:therapeutic use*; D051381:Rats; D011916:Rats, Inbred F344; D014134:Tracheal Neoplasms / Q000098:blood supply / Q000473:pathology / Q000532:radiotherapy*; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D001729:Bismuth