[The relationship of carcinoembryonic antigen and neutrophils to pulmonary function in healthy smokers].
We evaluated the relationship of carcinoembryonic antigen (CEA) and neutrophils to pulmonary function in healthy smokers. Smokers in whom levels of CEA were greater than 5.0 ng/ml (n = 70) and in whom CEA levels were 5.0 ng/ml or less (n = 693) had significantly higher mean concentrations of leukocytes and neutrophils than non-smokers (n = 651) (leukocytes: 6,883 +/- 1,889/mm3 or 5,581 +/- 1,457/mm3 vs. 4,507 +/- 1,111/mm3, p < 0.01; neutrophils: 4,389 +/- 1,542/mm3 or 3,343 +/- 1,164/mm3 vs. 2,700 +/- 884/mm3, p < 0.01). Differences in the ratio of vital capacity to the predicted vital capacity (%VC) were not significant. In addition, the ratio of forced expiratory volume in one second to forced vital capacity (FEV 1.0%) in smokers with CEA levels greater than 5.0 ng/ml was decreased compared with smokers with CEA levels of 5.0 ng/ml or less and in non-smokers (90.2 +/- 8.4% vs. 93.3 +/- 6.7% or 92.9 +/- 6.5%, p < 0.01). These results suggest that in healthy smokers high serum CEA levels are related to a decreased FEV 1.0%.
Kashiwabara
K
K
5th Department of Internal Medicine, Tokyo Medical College, Ibaraki, Japan.
Nakamura
H
H
Kishi
K
K
Kiguchi
T
T
Yagyu
H
H
Kobayashi
K
K
Matsuoka
T
T
D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D012119:Respiration; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects / Q000276:immunology*
D002272:Carcinoembryonic Antigen