[Hemo- and immunostimulating effect of an extract from blood cells of the Central Asian tortoise].
Radiotherapeutic efficacious of the compounds from major organs and tissues of Central Asian tortoise--the animal known for its unique radioresistance, has been checked up. Along with the so well-known compounds as the plasma ones, tortoise spleen extracts (TSE) and the ones from the liver of adult animals and embryos, extracts from kidneys and muscles have been shown to increase the survivability rate of irradiated rats and mice. The compound, that called "Tortezin" shows the highest blood cell cytosol effect. The specific activity and the output are 4 and 12 times higher, than the ones of TSE, respectively. Dose increase factor (DIF) reaches as far as 1.41. The compound possesses considerable immunostimulating activity. The detailed physico-chemical characteristics of the compound, quite sufficient for its identification has been made.
Turd'iev
A A
AA
Institute of Biochemistry, Academy of Sciences Republic of Uzbekistan, Tashkent. azim@inst.silu.glas.ape.org
Aleksandrov
V V
VV
Usmanov
R B
RB
Batyrbekov
A A
AA
Ivanov
V I
VI
Filiutovich
O S
OS
Tagaĭalieva
N A
NA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D001773:Blood Cells / Q000378:metabolism; D001854:Bone Marrow Cells / Q000378:metabolism / Q000528:radiation effects; D003600:Cytosol / Q000378:metabolism; D005260:Female; D006397:Hematinics / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013936:Thymidine / Q000378:metabolism; D014020:Tissue Extracts / Q000627:therapeutic use; D014426:Turtles / Q000097:blood / Q000502:physiology
D000276:Adjuvants, Immunologic; D006397:Hematinics; D011837:Radiation-Protective Agents; D014020:Tissue Extracts; D013936:Thymidine
Gemo- i immunostimuliruiushchiĭ éffekt ékstrakta kletok krovi sredneaziatskoĭ cherepakhi.