title: Previous breast biopsy for benign disease rarely complicates or alters interpretation on screening mammography.
abstract: OBJECTIVE
  It has been suggested that breast screening leads to too many biopsies for benign disease that permanently scar the breast and confuse the interpretation of subsequent mammograms. We undertook retrospective and prospective studies to determine how often an excisional biopsy for benign breast disease complicates or alters interpretation of screening mammograms.
  
  
  METHODS
  Retrospective review of our screening center database yielded 31,025 asymptomatic patients who had routine mammographic screening studies between 1993 and 1996. Of the 58,538 examinations of these patients, 53,510 were of patients who had no history of breast biopsy and 5028 were of patients who had a history of breast biopsy for benign disease. Recall rates were compared between the two groups. In the prospective study, radiologists reviewed the mammograms of 1997 consecutive patients presenting to the screening center, 173 of whom reported a prior breast biopsy for benign disease. The radiologist interpreting the images determined how often evidence of the biopsy site was apparent on the mammogram and how often such changes necessitated additional imaging.
  
  
  RESULTS
  In the retrospective study, 3296 (6%) of the 53,510 studies done in patients who did not have a biopsy for benign disease and 360 (7%) of the 5028 studies done in women who had a biopsy for benign disease led to additional imaging. Eight recalls for further imaging (0.16%) among the 5028 studies in women with a prior biopsy for benign disease were related to the biopsy site. In the prospective study, 24 (14%) of the 173 women who had a biopsy for benign disease had mammographic evidence of the biopsy site. Nine (5%) of the 173 women who had previously had a biopsy for benign disease and 86 (5%) of the 1824 patients without a prior biopsy were recalled for additional imaging. No women were recalled because a previous breast biopsy for benign disease led to confusion or diagnostic concern.
  
  
  CONCLUSIONS
  Changes in patients' breasts due to previous excisional biopsies for benign breast disease rarely pose a diagnostic dilemma in the interpretation of routine screening mammograms.
authors.affiliation: Department of Radiology (ACC 219), Massachusetts General Hospital and the Harvard Medical School, Boston 02114, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Slanetz
authors.forename: A A
authors.initials: AA
authors.lastname: Giardino
authors.forename: K A
authors.initials: KA
authors.lastname: McCarthy
authors.forename: D A
authors.initials: DA
authors.lastname: Hall
authors.forename: E F
authors.initials: EF
authors.lastname: Halpern
authors.forename: R H
authors.initials: RH
authors.lastname: Moore
authors.forename: D B
authors.initials: DB
authors.lastname: Kopans
mesh_terms: D001706:Biopsy / Q000009:adverse effects*; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000473:pathology*; D003955:Diagnostic Tests, Routine; D005260:Female; D006801:Humans; D008327:Mammography; D011446:Prospective Studies; D012189:Retrospective Studies