Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy.
Tau-containing filaments purified from the brain of progressive supranuclear palsy (PSP) patients were isolated and characterized. These filaments co-purify with regular particles that biophysical and biochemical methods identified as ferritin shells. In vivo, brain tau accumulation in PSP co-localized with ferritin. These results suggest that ferritin/iron could modulate the formation of tau aggregates in PSP.
Pérez
M
M
Centro de Biología Molecular Severo Ochoa Universidad Autónoma de Madrid, Spain.
Valpuesta
J M
JM
de Garcini
E M
EM
Quintana
C
C
Arrasate
M
M
López Carrascosa
J L
JL
Rábano
A
A
García de Yébenes
J
J
Avila
J
J
D001921:Brain / Q000378:metabolism; D002421:Caudate Nucleus / Q000378:metabolism; D002847:Chromatography, Agarose; D004577:Electron Probe Microanalysis; D005293:Ferritins / Q000032:analysis* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron; D013494:Supranuclear Palsy, Progressive / Q000378:metabolism / Q000473:pathology*; D016875:tau Proteins / Q000032:analysis* / Q000378:metabolism / Q000648:ultrastructure
D016875:tau Proteins; D005293:Ferritins