Generalized erythematous skin eruptions due to trimethoprim itself and co-trimoxazole.
A 20-year-old Japanese woman (Case 1) and a 70-year-old Japanese man (Case 2) consulted us with slight fever and disseminated erythematous papules. Examinations revealed that the first case was a skin eruption due to trimethoprim itself and the second was due to both trimethoprim and sulphamethoxazole. To our knowledge, our Case 1 is the first reported case with an erythematous papular type skin eruption caused by trimethoprim itself, and our Case 2 is the first case of a skin eruption in reaction to both trimethoprim and sulphamethoxazole.
Hattori
N
N
Department of Dermatology, Kanto Central Hospital, Tokyo, Japan.
Hino
H
H
D000328:Adult; D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects* / Q000627:therapeutic use; D003556:Cystitis / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D011472:Prostatitis / Q000188:drug therapy; D014295:Trimethoprim / Q000009:adverse effects* / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use
D000892:Anti-Infective Agents, Urinary; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim