Does the latency associated transcript (LAT) of herpes simplex virus (HSV) function as a ribozyme during viral reactivation?
The latency associated transcript (LAT) of herpes simplex virus (HSV) appears to exist as an RNA molecule only. This phenomenon is consistent with the concept of functioning at an RNA level, and several lines of evidence suggest that the LAT may be a ribozyme. This provides an insight into understanding the role of LAT during HSV reactivation.
Hui
E K
EK
Institute of Microbiology and Immunology (IMI), School of Life Science, National Yang-Ming University (NYMU), Taipei, Taiwan, Republic of China.
Lo
S J
SJ
D018259:Herpesvirus 1, Human / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D018258:Herpesvirus 2, Human / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D016337:RNA, Catalytic / Q000502:physiology*; D012367:RNA, Viral / Q000502:physiology; D014775:Virus Activation / Q000502:physiology*; D017735:Virus Latency / Q000502:physiology*
D016337:RNA, Catalytic; D012367:RNA, Viral