title: Failure of once-daily vancomycin for staphylococcal endocarditis.
abstract: With the emergence of staphylococci as important hospital pathogens, administration of vancomycin has increased dramatically. Economic and other factors have led to the development of once-daily dosing protocols to simplify and standardize the administration of antibiotics. A patient with Staphylococcus aureus prosthetic valve endocarditis and normal renal function failed therapy with vancomycin once/day. The infection was cured when the regimen was changed to the conventional 12-hour dosing interval.
authors.affiliation: Department of Medicine, University of Massachusetts, St. Vincent Hospital, Worcester 01604, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Marik
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000209:etiology; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000209:etiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology; D014640:Vancomycin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin